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Sample records for bearing thermocleavable benzoate

  1. Photovoltaic Performance of Polymers Based on Dithienylthienopyrazines Bearing Thermocleavable Benzoate Esters

    DEFF Research Database (Denmark)

    Petersen, Martin Helgesen; Krebs, Frederik C

    2010-01-01

    are in the range of 1.17−1.37 eV. The polymers were explored as donor materials in bulk heterojunction solar cells together with PCBM as the acceptor material where they were shown to exhibit a photoresponse in the full absorption range up to 900 nm and power conversion efficiencies of up to 1.21% under 1 sun...

  2. Method of Thermocleaving a Polymer Layer

    DEFF Research Database (Denmark)

    2010-01-01

    A method of thermocleaving a thermocleavable polymer layer which is in thermal contact with a heat sensitive component that is not tolerant of the temperature required for thermocleavage of the thermocleavable polymer layer, in which the thermocleavable polymer layer is illuminated with a light...... source having a wavelength range more strongly absorbed by the thermocleavable polymer and substantially less strongly absorbed by the heat sensitive component, such that the thermocleavable polymer layer reaches a temperature sufficient to cause thermocleavage of the polymer without causing detrimental...

  3. Thermo-cleavable polymers: Materials with enhanced photochemical stability

    DEFF Research Database (Denmark)

    Manceau, Matthieu; Petersen, Martin Helgesen; Krebs, Frederik C

    2010-01-01

    Photochemical stability of three thermo-cleavable polymers was investigated as thin films under atmospheric conditions. A significant increase in lifetime was observed once the side-chain was cleaved emphasizing the detrimental effect of solubilizing groups on the photochemical stability of conju......Photochemical stability of three thermo-cleavable polymers was investigated as thin films under atmospheric conditions. A significant increase in lifetime was observed once the side-chain was cleaved emphasizing the detrimental effect of solubilizing groups on the photochemical stability...... of conjugated polymers. In addition to their ease of processing, thermo-cleavable polymers thus also offer a greater intrinsic stability under illumination....

  4. Thermocleavable pi-Conjugated polymers. Synthesis and photovoltaic applications

    Energy Technology Data Exchange (ETDEWEB)

    Helgesen, M.

    2009-10-15

    Polymer solar cells (plastic solar cells) have seen remarkable improvements in recent years where power conversion efficiencies of up to 6% have been reported for small area devices. However in terms of stability polymer solar cells degrade during illumination and in the dark leading to operational lifetimes that are generally very poor. There has been a recent interest in the operational stability of devices and more importantly on the understanding of why devices and materials break down. This has lead to the discovery of a new class of materials that enable exceptionally long device lifetimes (>20000 hours). This Ph.D. thesis describes the synthesis, characterization and photovoltaic applications of these novel polymer materials. A key feature of these materials is that solubilizing thermocleavable alkyl ester side chains are introduced on the polymer backbone. The side chains make the polymer soluble in organic solvents and allow film formation via solution processing. Subsequently they can be removed by heating in a post-processing step forming a harder insoluble material with enhanced stability. These new thermocleavable materials can potentially offer higher chromophore density, higher level processing and improved stability in a solar cell device. Methods are developed for the incorporation of alkoxy chains and thermocleavable ester groups on the benzothiadiazole and the thiophene units in an attempt to evolve the PDTBT system to a more advanced level. The synthesis and photovoltaic applications of the PDTTP and PDTBT systems is described. (author)

  5. Thermo-cleavable solvents for printing conjugated polymers: Application in polymer solar cells

    DEFF Research Database (Denmark)

    Jørgensen, Mikkel; Hagemann, Ole; Alstrup, Jan

    2009-01-01

    The synthesis and characterization of a number of so-called thermo-cleavable solvents are described with their application in all-air, all-solution and all-screen-printed polymer solar cells. These solvents were developed to meet some requirements for printing techniques such as long “open time...

  6. Thermocleavable π‐Conjugated Polymers – Synthesis and photovoltaic applications

    DEFF Research Database (Denmark)

    Petersen, Martin Helgesen

    Polymer solar cells (plastic solar cells) have seen remarkable improvements in recent years where power conversion efficiencies of up to 6% have been reported for small area devices. However in terms of stability polymer solar cells degrade during illumination and in the dark leading to operational...... (>20000 hours). This Ph.D. thesis describes the synthesis, characterization and photovoltaic applications of these novel polymer materials. A key feature of these materials is that solubilizing thermocleavable alkyl ester side chains are introduced on the polymer backbone. The side chains make the polymer...... level processing and improved stability in a solar cell device....

  7. Thermocleavable Materials for Polymer Solar Cells with High Open Circuit Voltage-A Comparative Study

    DEFF Research Database (Denmark)

    Tromholt, Thomas; Gevorgyan, Suren; Jørgensen, Mikkel;

    2009-01-01

    The search for polymer solar cells giving a high open circuit voltage was conducted through a comparative study of four types of bulk-heterojunction solar cells employing different photoactive layers. As electron donors the thermo-cleavable polymer poly-(3-(2-methylhexyloxycarbonyl)dithiophene) (P3......MHOCT) and unsubstituted polythiophene (PT) were used, the latter of which results from thermo cleaving the former at 310 °C. As reference, P3HT solar cells were built in parallel. As electron acceptors, either PCBM or bis-[60]PCBM were used. In excess of 300 solar cells were produced under as identical...

  8. All solution processed tandem polymer solar cells based on thermocleavable materials

    DEFF Research Database (Denmark)

    Hagemann, Ole; Bjerring, Morten; Nielsen, Niels Chr.

    2008-01-01

    Multilayer tandem polymer solar cells were prepared by solution processing using thermocleavable polymer materials that allow for conversion to an insoluble state through a short thermal treatment. The problems associated with solubility during application of subsequent layers in the stack were...... efficiently solved. Devices comprised a transparent front cathode based on solution processed zinc oxide nanoparticles, a large band gap active layer based on a bulk heterojunction between zinc oxide and poly(3-carboxydithiophene) (P3CT) followed by a layer of PEDOT:PSS processed from water. The second cell...

  9. Bear

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The famous physicist made for his scholars this riddle. A fellow encountered a bear in a wasteland. There was nobody else there. Both were frightened and ran away. Fellow to the north, bear to the west. Suddenly the fellow stopped, aimed his gun to the south and shot the bear. What colour was the bear?

  10. (Benzoylaminomethyl 4-[(Benzoylaminomethoxy]benzoate

    Directory of Open Access Journals (Sweden)

    Ana Poceva Panovska

    2010-12-01

    Full Text Available In this note, two procedures for the synthesis of (benzoylaminomethyl 4-[(benzoylamino­methoxy]benzoate (3 are presented. The first procedure is carried out in dioxane/water using benzoylaminomethyl-4-hydroxybenzoate, while the second one employs a suspension of 4-hydroxy­benzoic acid in dioxane. In both procedures, benzamidomethyl triethylammonium chloride is used for the benzamidomethylation reaction.

  11. Vibrational Spectroscopy of Methyl benzoate

    CERN Document Server

    Maiti, Kiran Sankar

    2014-01-01

    Methyl benzoate (MB) is studied as a model compound for the development of new IR pulse schemes with possible applicability to biomolecules. Anharmonic vibrational modes of MB are calculated on different level (MP2, SCS, CCSD(T) with varying basis sets) ab-initio PESs using the vibrational self-consistent field (VSCF) method and its correlation corrected extensions. Dual level schemes, combining different quantum chemical methods for diagonal and coupling potentials, are systematically studied and applied successfully to reduce the computational cost. Isotopic substitution of {\\beta}-hydrogen by deuterium is studied to obtain a better understanding of the molecular vibrational coupling topology.

  12. Generation of native polythiophene/PCBM composite nanoparticles via the combination of ultrasonic micronization of droplets and thermocleaving from aqueous dispersion

    DEFF Research Database (Denmark)

    Nan, Yaxiong; Hu, Xiaolian; Larsen-Olsen, Thue Trofod

    2011-01-01

    involve both ultrasonic generation of microdroplets in argon as a carrier gas and drying followed by thermocleaving of the P3MHOCT component in the gas phase. The chemical transition from P3MHOCT to n-PT was confirmed by Fourier transform infrared (FTIR) spectroscopy. The morphology and size of n....... The successful vapour-phase preparation of phase-separated n-PT/PCBM nanoparticles provides a new route to all-aqueous processing of conjugated materials relevant to efficient polymer solar cells with long operational stability. The use of ultrasound was involved in both liquid and gas phases demonstrating...

  13. Interaction of theobromine with sodium benzoate

    Energy Technology Data Exchange (ETDEWEB)

    Nishijo, J.; Yonetani, I.

    1982-03-01

    The interaction of theobromine with sodium benzoate was investigated by PMR spectroscopy. The interaction of theobromine with pentadeuterated benzoic acid (benzoic acid-d5) was examined in the same manner but to a lesser degree. Chemical shifts of theobromine protons were determined as a function of sodium benzoate concentration in deuterium oxide at 30 and 15 degrees. Signals of both methyl groups of theobromine underwent significant upfield shifts when sodium benzoate was added to a theobromine solution. This fact suggests that a complex is formed by vertical stacking or plane-to-plane stacking. The same results were obtained for benzoic acid-d5.

  14. Conductive iron oxide minerals accelerate syntrophic cooperation in methanogenic benzoate degradation

    Energy Technology Data Exchange (ETDEWEB)

    Zhuang, Li; Tang, Jia; Wang, Yueqiang; Hu, Min; Zhou, Shungui, E-mail: sgzhou@soil.gd.cn

    2015-08-15

    Highlights: • Paddy soil contaminated with benzoate incubated with hematite and magnetite. • Iron oxides addition enhanced methanogenic benzoate degradation by 25–53%. • The facilitated syntrophy might involve direct interspecies electron transfer. • Bacillaceae, Peptococcaceae, and Methanobacterium are potentially involved. - Abstract: Recent studies have suggested that conductive iron oxide minerals can facilitate syntrophic metabolism of the methanogenic degradation of organic matter, such as ethanol, propionate and butyrate, in natural and engineered microbial ecosystems. This enhanced syntrophy involves direct interspecies electron transfer (DIET) powered by microorganisms exchanging metabolic electrons through electrically conductive minerals. Here, we evaluated the possibility that conductive iron oxides (hematite and magnetite) can stimulate the methanogenic degradation of benzoate, which is a common intermediate in the anaerobic metabolism of aromatic compounds. The results showed that 89–94% of the electrons released from benzoate oxidation were recovered in CH{sub 4} production, and acetate was identified as the only carbon-bearing intermediate during benzoate degradation. Compared with the iron-free controls, the rates of methanogenic benzoate degradation were enhanced by 25% and 53% in the presence of hematite and magnetite, respectively. This stimulatory effect probably resulted from DIET-mediated methanogenesis in which electrons transfer between syntrophic partners via conductive iron minerals. Phylogenetic analyses revealed that Bacillaceae, Peptococcaceae, and Methanobacterium are potentially involved in the functioning of syntrophic DIET. Considering the ubiquitous presence of iron minerals within soils and sediments, the findings of this study will increase the current understanding of the natural biological attenuation of aromatic hydrocarbons in anaerobic environments.

  15. 21 CFR 582.3733 - Sodium benzoate.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Sodium benzoate. 582.3733 Section 582.3733 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS SUBSTANCES GENERALLY RECOGNIZED AS SAFE Chemical Preservatives §...

  16. Anaerobic degradation of benzoate by sulfate-reducing bacteria

    Energy Technology Data Exchange (ETDEWEB)

    Silva, S.P.; Adorno, M.A.T.; Moraes, E.M.; Varesche, M.B.A. [Sao Paulo Univ., Sao Carlos, SP (Brazil). Biological Processes Laboratory

    2004-07-01

    Anaerobic processes are an efficient way to degrade aromatic compounds in industrial wastewater, such as phenol, cresol and benzoate. This study characterized the bacteria that degrades benzoate, an anaerobic degradation intermediate of several complex aromatic compounds. In particular, the study assessed the capacity to use benzoate with sulfate reducing bacteria in mesophilic conditions. Biofilm from polyurethane foam matrices of a fixed bed reactor was used as the cellular inoculum to treat industrial wastewater containing organic peroxide. Dilution techniques were used to purify the material and obtain cultures of cocci. The benzoate consumption capacity in sulfidogenic conditions was observed when the purified inoculum was applied to batch reactors with different benzoate/sulfate relations. Results indicate that purification was positive to bacteria that can degrade aromatic compounds. Desulfococcus multivorans bacteria was identified following the physiologic and kinetic experiments. The 0.6 benzoate/sulfate relation was considered ideal for complete consumption of carbon and total use of sulfur. 10 refs., 3 figs.

  17. Radiation and thermal polymerization of allyl(p-allylcarbonate) benzoate

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-V, D., E-mail: dlopez@siu.buap.m [Facultad de Ciencias Quimicas, Benemerita Universidad Autonoma de Puebla, Antiguo Edificio de la Fac. de Cs., Quimica. Av. San Claudio y Boulevard de la 14 sur, Col. San Manuel, Puebla, Pue., CP 72500 (Mexico); Herrera-G, A.M., E-mail: mherrera@uaeh.reduaeh.m [Centro de Inv. en Materiales y Metalurgia, UAEH. Km 4.5, C.U., CP 42184, Pachuca de S. Hidalgo (Mexico); Castillo-Rojas, S., E-mail: castillo@nucleares.unam.m [Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, 04510 DF (Mexico)

    2011-03-15

    Bulk polymerization of novel allyl(p-allylcarbonate) benzoate was investigated using different sources of energy, such as gamma rays, ultraviolet rays as well as thermal polymerization. The poly(allyl(p-allylcarbonate) benzoate) obtained is a cross-linking, transparent, thermoset polycarbonate. Compositions of the monomer and the polycarbonate were analyzed by infrared spectroscopy, elemental analysis, and {sup 1}H NMR spectroscopy.

  18. Safety assessment of alkyl benzoates as used in cosmetics.

    Science.gov (United States)

    'Becker, Lillian C; Bergfeld, Wilma F; Belsito, Donald V; Hill, Ronald A; Klaassen, Curtis D; Liebler, Daniel; Marks, James G; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Andersen, F Alan

    2012-01-01

    The functions of alkyl benzoates in cosmetics include fragrance ingredients, skin-conditioning agents--emollient, skin-conditioning agents--miscellaneous, preservatives, solvents, and plasticizers. The Cosmetic Ingredient Review Expert Panel reviewed the relevant animal and human data and noted gaps in the available safety data for some of the alkyl benzoates. Similar structure activity relationships, biologic functions, and cosmetic product usage allowed the available data of many of the alkyl benzoates to be extended to the entire group. Carcinogenicity data were not available, but available data indicated that these alkyl benzoate cosmetic ingredients are not genotoxic. Also benzoic acid and tested component alcohols were not reproductive or developmental toxicants, are not genotoxic in almost all assays, and are not carcinogenic. These ingredients were determined to be safe in the present practices of use and concentration.

  19. Synthesis and Crystal Structure of Tetranuclear Zinc Benzoate

    Institute of Scientific and Technical Information of China (English)

    YIN Ming-cai; WANG Chi-wei; AI Chang-chun; YUAN Liang-jie; SUN Ju-tang

    2004-01-01

    A tetranuclear zinc benzoate Zn4O(C6H5CO2)6 was synthesized and characterized by X-ray single crystal determination. It crystallizes in cubic, space group Ia-3d. Its crystal cell is very large, a=4.100 63(18) nm, V=68.953(5) nm3 and Z = 48. The structure is composed of discrete Zn4O(C6H5CO2)6 molecules. In each molecule, four zinc atoms are held together by a central oxygen atom, which results in the formation of a regular tetrahedron. All benzoate ligands coordinate to zinc atoms in a bidentate bridging mode. Each zinc atom is in a slightly distorted tetrahedral geometry, coordinated by three benzoate oxygen atoms and the central oxygen atom. The intermolecular interactions result in the formation of a three-dimensional supramolecular framework, with non-intersecting parallel channels.

  20. Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine☆

    OpenAIRE

    Yao,Gang; Man, Yuhong; Luo, Xiangdan; Yu, Tingmin; Ji, Lin

    2012-01-01

    The present study utilized a nitroglycerin-induced rat model of migraine to detect the effects of rizatriptan benzoate on proenkephalin and substance P gene expression in the midbrain using real-time quantitative polymerase chain reaction and investigate whether rizatriptan benzoate can regulate the endogenous pain modulatory system. The results showed that rizatriptan benzoate significantly reduced expression of the mRNAs for proenkephalin and substance P. Rizatriptan benzoate may inhibit th...

  1. Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine.

    Science.gov (United States)

    Yao, Gang; Man, Yuhong; Luo, Xiangdan; Yu, Tingmin; Ji, Lin

    2012-01-15

    The present study utilized a nitroglycerin-induced rat model of migraine to detect the effects of rizatriptan benzoate on proenkephalin and substance P gene expression in the midbrain using real-time quantitative polymerase chain reaction and investigate whether rizatriptan benzoate can regulate the endogenous pain modulatory system. The results showed that rizatriptan benzoate significantly reduced expression of the mRNAs for proenkephalin and substance P. Rizatriptan benzoate may inhibit the analgesic effect of the endogenous pain modulatory system.

  2. Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine

    Institute of Scientific and Technical Information of China (English)

    Gang Yao; Yuhong Man; Xiangdan Luo; Tingmin Yu; Lin Ji

    2012-01-01

    The present study utilized a nitroglycerin-induced rat model of migraine to detect the effects of rizatriptan benzoate on proenkephalin and substance P gene expression in the midbrain using real-time quantitative polymerase chain reaction and investigate whether rizatriptan benzoate can regulate the endogenous pain modulatory system. The results showed that rizatriptan benzoate significantly reduced expression of the mRNAs for proenkephalin and substance P. Rizatriptan benzoate may inhibit the analgesic effect of the endogenous pain modulatory system.

  3. Thermoreversible biogels for intranasal delivery of rizatriptan benzoate

    Directory of Open Access Journals (Sweden)

    Chand Renuka

    2009-01-01

    Full Text Available The objective of the present study was to formulate and evaluate a thermoreversible formulation containing rizatriptan benzoate for intranasal administration. Chitosan and aqueous β-glycerolphosphate were mixed in cold condition to obtain chitosan-β-glycerolphosphate mixtures, which served as the thermoreversible systems. Rizatriptan benzoate was incorporated at a final strength of 25 mg/ml. Both in vitro release and ex vivo permeation of rizatriptan from gels were measured at 37º using Franz diffusion cells Formulations were tested in vivo in mice for reduction in locomotor activity using digital actophotometer and nasal mucosal tissues were examined histopathologically.

  4. 77 FR 31722 - New Animal Drugs; Change of Sponsor; Estradiol; Estradiol Benzoate and Testosterone Propionate...

    Science.gov (United States)

    2012-05-30

    ... COMPONENT E-C 522.1940 (progesterone and estradiol benzoate) with TYLAN (tylosin tartrate). COMPONENT E-S (progesterone and estradiol benzoate) with TYLAN (tylosin tartrate). 118-123 COMPONENT 200 (estradiol benzoate... and testosterone propionate) with TYLAN (tylosin tartrate). 200-221 COMPONENT TE-IS...

  5. ISOLATION AND CHARACTERIZATION OF A NOVEL BENZOATE- UTILIZING Serratia marcescens

    Directory of Open Access Journals (Sweden)

    ANTONIUS SUWANTO

    2003-01-01

    Full Text Available A new benzoate-utilizing strain, Serratia marcescens DS-8, isolated from the environment was characterized. The strain was enterobacilli, Gram negative, mesophilic, non ha lophilic, and aerobic bacterium that showed motile ovale-rod shaped cells. The isolate produced extracellular chitinase, protease, and prodigiosin (a red pigment pr oduced by several Serratia strains yielding bright red or pink colonies. A physiological assay using Microbact* test showed that the strain was closely related to Klebsiella ozaenae (49.85% and Serratia liquefaciens (24.42%, respectively. However, 16S rRNA sequence analysis indicated that the strain was closely related to S. marcescens DSM 30121 with similarity level of 98%. DS-8 strain was able to synthesize its own vitamins. Optimum growth in benzoate was obtained at pH between 7-8.5 and NaCl concentration of 1- 1.5% (w/v. The isolate could grow in benzoate-containing medium up to 10 mM. Other carbon sources that could support the growth of DS-8 were casamino acid, glutamate, glucose, acetate, potato star ch, and ethanol.

  6. Interspecies acetate transfer influences the extent of anaerobic benzoate degradation by syntrophic consortia

    Energy Technology Data Exchange (ETDEWEB)

    Warikoo, V.; McInerney, M.J.; Suflita, J.M. [and others

    1997-03-01

    Benzoate degradation by an anaerobic, syntrophic bacterium, strain SB, in coculture with Desulfovibrio strain G-11 reached a threshold value which depended on the amount of acetate added, and ranged from about 2.5 to 29.9 {mu}M. Increasing acetate concentrations also uncompetitively inhibited benzoate degradation. The apparent V{sub max} and K{sub m} for benzoate degradation decreased with increasing acetate concentration, but the benzoate degradation capacity (V{sub max}/K{sub m}) of cell suspensions remained comparable. The addition of an acetate-using bacterium to cocultures after the threshold was reached resulted in the degradation of benzoate to below the detection limit. Mathematical simulations showed that the benzoate threshold was not predicted by the inhibitory effect of acetate on benzoate degradation kinetics. With nitrate instead of sulfate as the terminal electron acceptor, no benzoate threshold was observed in the presence of 20 mM acetate even though the degradation capacity was lower with nitrate than with sulfate. When strain SB was grown with a hydrogen-using partner that had a 5-fold lower hydrogen utilization capacity, a 5 to 9-fold lower the benzoate degradation capacity was observed compared to SB/G-11 cocultures. The Gibb`s free energy for benzoate degradation was less negative in cell suspensions with threshold compared to those without threshold. These studies showed that the threshold was not a function of the inhibition of benzoate degradation capacity by acetate, or the toxicity of the undissociated form of acetate. Rather a critical or minimal Gibb`s free energy may exist where thermodynamic constraints preclude further benzoate degradation.

  7. Analisa Pengawet Natrium Benzoat Pada Manisan Buah Di Pasar Tradisional Kota Medan Tahun 2010.

    OpenAIRE

    Amalia Kurnia Sari P

    2011-01-01

    Preservative sodium benzoate chemical with formula of C7H5O2 This research was a descriptive survey researched that analyzed the content of sodium benzoate on the candied fruit. Fruit with total sampling 12 sample candied fruit consisting of three kinds of fruit, salak, mango and kedondong. Primary data from this research were obtained from laboratory test on sodium benzoate preservative substences contained in the candied fruit. Data obtained were analyzed descriptively. Na were Substance...

  8. Determination of Hammett Equation Rho Constant for the Hydrolysis of p-Nitrophenyl Benzoate Esters

    Science.gov (United States)

    Keenan, Sheue L.; Peterson, Karl P.; Peterson, Kelly; Jacobson, Kyle

    2008-01-01

    Seven p-nitrophenyl benzoate esters (p-nitrophenyl benzoate, p-nitrophenyl m-anisate, p-nitrophenyl p-anisate, p-nitrophenyl m-chlorobenzoate, p-nitrophenyl p-chlorobenzoate, p-nitrophenyl m-toluate, p-nitrophenyl p-toluate) were synthesized and characterized by students in a second-semester organic laboratory course. In a subsequent laboratory…

  9. 40 CFR 721.4060 - Alkylene glycol tereph-tha-late and substituted benzoate esters (generic name).

    Science.gov (United States)

    2010-07-01

    ... substituted benzoate esters (generic name). 721.4060 Section 721.4060 Protection of Environment ENVIRONMENTAL... substituted benzoate esters (generic name). (a) Chemical substance and significant new uses subject to... substituted benzoate esters (PMN P-89-596) is subject to reporting under this section for the significant...

  10. Formulation and evaluation of rizatriptan benzoate mouth disintegrating tablets.

    Science.gov (United States)

    Keny, R V; Desouza, Chrisma; Lourenco, C F

    2010-01-01

    The present investigation deals with development of mouth disintegrating tablets of rizatriptan benzoate to produce the intended benefits. Mouth disintegrating tablets of rizatriptan benzoate were prepared using superdisintegrants crospovidone, carboxymethylcellulose calcium, Indion 414 and Indion 234 using the direct compression method. The tablets prepared were evaluated for thickness, uniformity of weight, content uniformity, hardness, friability, wetting time, in vitro and in vivo disintegration time, mouth feel, in vitro drug release and assay by high performance liquid chromatography. The tablets disintegrated in vitro and in vivo within 4 to 7 s and 6 to 19 s, respectively. Almost 90% of drug was released from all formulations within 20 min. The drug release from the formulations followed first order kinetics. Stability studies of the tablets at 40+/-2 degrees /75%+/-5% RH for 1 mo showed non significant drug loss. The formulation containing combination of crospovidone and Indion 234 was found to give the best results. Apart from fulfilling all official and other specifications, the tablets exhibited higher rate of release.

  11. Formulation and evaluation of rizatriptan Benzoate mouth disintegrating tablets

    Directory of Open Access Journals (Sweden)

    Keny R

    2010-01-01

    Full Text Available The present investigation deals with development of mouth disintegrating tablets of rizatriptan benzoate to produce the intended benefits. Mouth disintegrating tablets of rizatriptan benzoate were prepared using superdisintegrants crospovidone, carboxymethylcellulose calcium, Indion 414 and Indion 234 using the direct compression method. The tablets prepared were evaluated for thickness, uniformity of weight, content uniformity, hardness, friability, wetting time, in vitro and in vivo disintegration time, mouth feel, in vitro drug release and assay by high performance liquid chromatography. The tablets disintegrated in vitro and in vivo within 4 to 7 s and 6 to 19 s, respectively. Almost 90% of drug was released from all formulations within 20 min. The drug release from the formulations followed first order kinetics. Stability studies of the tablets at 40±2 o /75%±5% RH for 1 mo showed non significant drug loss. The formulation containing combination of crospovidone and Indion 234 was found to give the best results. Apart from fulfilling all official and other specifications, the tablets exhibited higher rate of release.

  12. Lean production of taste improved lipidic sodium benzoate formulations.

    Science.gov (United States)

    Eckert, C; Pein, M; Breitkreutz, J

    2014-10-01

    Sodium benzoate is a highly soluble orphan drug with unpleasant taste and high daily dose. The aim of this study was to develop a child appropriate, individually dosable, and taste masked dosage form utilizing lipids in melt granulation process and tableting. A saliva resistant coated lipid granule produced by extrusion served as reference product. Low melting hard fat was found to be appropriate as lipid binder in high-shear granulation. The resulting granules were compressed to minitablets without addition of other excipients. Compression to 2mm minitablets decreased the dissolved API amount within the first 2 min of dissolution from 33% to 23%. The Euclidean distances, calculated from electronic tongue measurements, were reduced, indicating an improved taste. The reference product showed a lag time in dissolution, which is desirable for taste masking. Although a lag time was not achieved for the lipidic minitablets, drug release in various food materials was reduced to 2%, assuming a suitable taste masking for oral sodium benzoate administration.

  13. Journal bearing

    Science.gov (United States)

    Menke, John R.; Boeker, Gilbert F.

    1976-05-11

    1. An improved journal bearing comprising in combination a non-rotatable cylindrical bearing member having a first bearing surface, a rotatable cylindrical bearing member having a confronting second bearing surface having a plurality of bearing elements, a source of lubricant adjacent said bearing elements for supplying lubricant thereto, each bearing element consisting of a pair of elongated relatively shallowly depressed surfaces lying in a cylindrical surface co-axial with the non-depressed surface and diverging from one another in the direction of rotation and obliquely arranged with respect to the axis of rotation of said rotatable member to cause a flow of lubricant longitudinally along said depressed surfaces from their distal ends toward their proximal ends as said bearing members are rotated relative to one another, each depressed surface subtending a radial angle of less than 360.degree., and means for rotating said rotatable bearing member to cause the lubricant to flow across and along said depressed surfaces, the flow of lubricant being impeded by the non-depressed portions of said second bearing surface to cause an increase in the lubricant pressure.

  14. Environmental fate of emamectin benzoate after tree micro injection of horse chestnut trees.

    Science.gov (United States)

    Burkhard, Rene; Binz, Heinz; Roux, Christian A; Brunner, Matthias; Ruesch, Othmar; Wyss, Peter

    2015-02-01

    Emamectin benzoate, an insecticide derived from the avermectin family of natural products, has a unique translocation behavior in trees when applied by tree micro injection (TMI), which can result in protection from insect pests (foliar and borers) for several years. Active ingredient imported into leaves was measured at the end of season in the fallen leaves of treated horse chestnut (Aesculus hippocastanum) trees. The dissipation of emamectin benzoate in these leaves seems to be biphasic and depends on the decomposition of the leaf. In compost piles, where decomposition of leaves was fastest, a cumulative emamectin benzoate degradation half-life time of 20 d was measured. In leaves immersed in water, where decomposition was much slower, the degradation half-life time was 94 d, and in leaves left on the ground in contact with soil, where decomposition was slowest, the degradation half-life time was 212 d. The biphasic decline and the correlation with leaf decomposition might be attributed to an extensive sorption of emamectin benzoate residues to leaf macromolecules. This may also explain why earthworms ingesting leaves from injected trees take up very little emamectin benzoate and excrete it with the feces. Furthermore, no emamectin benzoate was found in water containing decomposing leaves from injected trees. It is concluded, that emamectin benzoate present in abscised leaves from horse chestnut trees injected with the insecticide is not available to nontarget organisms present in soil or water bodies.

  15. Effect of Emamectin Benzoate on Root-Knot Nematodes and Tomato Yield.

    Directory of Open Access Journals (Sweden)

    Xingkai Cheng

    Full Text Available Southern root-knot nematode (Meloidogyne incognita is an obligate, sedentary endoparasite of more than 3000 plant species, that causes heavy economic losses and limit the development of protected agriculture of China. As a biological pesticide, emamectin benzoate has effectively prevented lepidopteran pests; however, its efficacy to control M. incognita remains unknown. The purpose of the present study was to test soil application of emamectin benzoate for management of M. incognita in laboratory, greenhouse and field trials. Laboratory results showed that emamectin benzoate exhibited high toxicity to M. incognita, with LC50 and LC90 values 3.59 and 18.20 mg L(-1, respectively. In greenhouse tests, emamectin benzoate soil application offered good efficacy against M. incognita while maintaining excellent plant growth. In field trials, emamectin benzoate provided control efficacy against M. incognita and resulted in increased tomato yields. Compared with the untreated control, there was a 36.5% to 81.3% yield increase obtained from all treatments and the highest yield was received from the highest rate of emamectin benzoate. The results confirmed that emamectin benzoate has enormous potential for the control of M. incognita in tomato production in China.

  16. Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans.

    Science.gov (United States)

    Lennerz, Belinda S; Vafai, Scott B; Delaney, Nigel F; Clish, Clary B; Deik, Amy A; Pierce, Kerry A; Ludwig, David S; Mootha, Vamsi K

    2015-01-01

    Sodium benzoate is a widely used preservative found in many foods and soft drinks. It is metabolized within mitochondria to produce hippurate, which is then cleared by the kidneys. We previously reported that ingestion of sodium benzoate at the generally regarded as safe (GRAS) dose leads to a robust excursion in the plasma hippurate level [1]. Since previous reports demonstrated adverse effects of benzoate and hippurate on glucose homeostasis in cells and in animal models, we hypothesized that benzoate might represent a widespread and underappreciated diabetogenic dietary exposure in humans. Here, we evaluated whether acute exposure to GRAS levels of sodium benzoate alters insulin and glucose homeostasis through a randomized, controlled, cross-over study of 14 overweight subjects. Serial blood samples were collected following an oral glucose challenge, in the presence or absence of sodium benzoate. Outcome measurements included glucose, insulin, glucagon, as well as temporal mass spectrometry-based metabolic profiles. We did not find a statistically significant effect of an acute oral exposure to sodium benzoate on glucose homeostasis. Of the 146 metabolites targeted, four changed significantly in response to benzoate, including the expected rise in benzoate and hippurate. In addition, anthranilic acid, a tryptophan metabolite, exhibited a robust rise, while acetylglycine dropped. Although our study shows that GRAS doses of benzoate do not have an acute, adverse effect on glucose homeostasis, future studies will be necessary to explore the metabolic impact of chronic benzoate exposure.

  17. Grizzly bear

    Science.gov (United States)

    Schwartz, C.C.; Miller, S.D.; Haroldson, M.A.; Feldhamer, G.; Thompson, B.; Chapman, J.

    2003-01-01

    The grizzly bear inspires fear, awe, and respect in humans to a degree unmatched by any other North American wild mammal. Like other bear species, it can inflict serious injury and death on humans and sometimes does. Unlike the polar bear (Ursus maritimus) of the sparsely inhabited northern arctic, however, grizzly bears still live in areas visited by crowds of people, where presence of the grizzly remains physically real and emotionally dominant. A hike in the wilderness that includes grizzly bears is different from a stroll in a forest from which grizzly bears have been purged; nighttime conversations around the campfire and dreams in the tent reflect the presence of the great bear. Contributing to the aura of the grizzly bear is the mixture of myth and reality about its ferocity. unpredictable disposition, large size, strength, huge canines, long claws, keen senses, swiftness, and playfulness. They share characteristics with humans such as generalist life history strategies. extended periods of maternal care, and omnivorous diets. These factors capture the human imagination in ways distinct from other North American mammals. Precontact Native American legends reflected the same fascination with the grizzly bear as modern stories and legends (Rockwell 1991).

  18. Preparation and Evaluation of Emamectin Benzoate Solid Microemulsion

    Directory of Open Access Journals (Sweden)

    Lei Feng

    2016-01-01

    Full Text Available The solid microemulsions of emamectin benzoate with the same content of surfactants were prepared by a self-emulsifying method. Emulsifier 600# and emulsifier 700# (3/2, w/w screened from eleven kinds of commonly used surfactants displayed great emulsifying properties. The redispersed solution of the solid microemulsion presented aqueous microemulsion characteristic. The mean particle size and polydispersity index were 10.34 ± 0.10 nm and 0.283 ± 0.013, respectively. The solid microemulsion showed excellent storage stability and the bioassay compared with water dispersible granules against diamondback moths provided a proof of its improved biological activities. This formulation could significantly reduce surfactants and is perspective in plant protection for improving bioavailability and environmental friendliness.

  19. 2-(1,3-Benzoxazol-2-yl-1-phenylethenyl benzoate

    Directory of Open Access Journals (Sweden)

    Mohammad Hassan Ghorbani

    2011-10-01

    Full Text Available In the title molecule, C22H15NO3, the configuration about the ethylenic double bond is Z configuration and it is approximately coplanar with the adjacent phenyl ring and benzoxazole ring system as indicated by the C(H=C(O—Cphenyl—Cphenyl and Obenzoxazole—C—C(H=C(O torsion angles of 179.88 (15 and 5.7 (2°, respectively. The dihedral angle between the essentially planar (r.m.s. deviation = 0.080 Å 2-(1,3-benzoxazol-2-yl-1-phenylethenyl group and the benzoate phenyl ring is 61.51 (6°. A short intramolecular O...O non-bonded interaction of 2.651 (2 Å is present.

  20. Methyl 4-[N-(5-bromopyrimidin-2-ylcarbamoyl]benzoate

    Directory of Open Access Journals (Sweden)

    Hui-Ling Hu

    2012-08-01

    Full Text Available In the title compound, C13H10BrN3O3, the pyrimidine and benzene rings are twisted with an interplanar angle of 58.4 (1°. The secondary amide group adopts a cis conformation with an H—N—C—O torsion angle of 14.8 (1°. In the crystal, molecules are connected into inversion dimers via pairs of N—H...N hydrogen bonds, generating an R22(8 motif. The dimers are further connected through a C—Br...O interaction [3.136 (1 Å and 169.31 (1°] into a chain along [110]. Weak C—H...N hydrogen bonds between the methyl benzoate groups and pyrimidine rings are also observed in the crystal structure.

  1. Alkaline earth layered benzoates as reusable heterogeneous catalysts for the methyl esterification of benzoic acid

    Directory of Open Access Journals (Sweden)

    Swamy Arêa Maruyama

    2012-01-01

    Full Text Available This paper describes the synthesis and characterization of layered barium, calcium and strontium benzoates and evaluates the potential of these materials as catalysts in the synthesis of methyl benzoate. The methyl esterification of benzoic acid was investigated, where the effects of temperature, alcohol:acid molar ratio and amount of catalyst were evaluated. Ester conversions of 65 to 70% were achieved for all the catalysts under the best reaction conditions. The possibility of recycling these metallic benzoates was also demonstrated, evidenced by unaltered catalytic activity for three consecutive reaction cycles.

  2. Toxicity and residual efficacy of chlorantraniliprole, spinetoram, and emamectin benzoate to obliquebanded leafroller (Lepidoptera: Tortricidae).

    Science.gov (United States)

    Sial, Ashfaq A; Brunner, Jay F

    2010-08-01

    Studies were conducted to determine the residual toxicity of spinetoram, chlorantraniliprole, and emamectin benzoate to obliquebanded leafroller, Choristoneura rosaceana (Harris) (Lepidoptera: Tortricidae). Larvae were exposed to apple (Malus spp.) foliage collected at different intervals after an airblast sprayer application at the manufacturer-recommended field rate and half the field rate. A mortality of 100% was recorded at field rate applications of spinetoram, chlorantraniliprole, and emamectin benzoate through 59, 38, and 10 d after treatment (DAT), respectively. Significantly less foliage was consumed by C. rosaceana larvae surviving in the emamectin, chlorantraniliprole, and spinetoram treatments compared with those exposed to untreated foliage. Third-instar C. rosaceana exposed to fresh residues on terminal foliage showed 100% mortality after 5-d exposure to spinetoram residues and after 10-d exposure to chlorantraniliprole and emamectin benzoate. The effects of larval movement from foliage with fresh residues was examined by transferring neonate larvae from foliage treated with spinetoram, chlorantraniliprole, or emamectin benzoate to untreated foliage after various exposure intervals. An exposure of 1, 3, and 6 d was required for spinetoram, chlorantraniliprole, and emamectin benzoate to cause 100% mortality at the field rate, respectively. The higher the concentration of chlorantraniliprole and emamectin benzoate, the less exposure time was necessary to cause high levels of mortality in C. rosaceana neonates. Our results indicate that these novel insecticides are highly toxic to C. rosaceana larvae. Implications of these results for C. rosaceana management programs are discussed.

  3. Foil bearings

    Science.gov (United States)

    Elrod, David A.

    1993-11-01

    The rolling element bearings (REB's) which support many turbomachinery rotors offer high load capacity, low power requirements, and durability. Two disadvantages of REB's are: (1) rolling or sliding contact within the bearing has life-limiting consequences; and (2) REB's provide essentially no damping. The REB's in the Space Shuttle Main Engine (SSME) turbopumps must sustain high static and dynamic loads, at high speeds, with a cryogenic fluid as lubricant and coolant. The pump end ball bearings limit the life of the SSME high pressure oxygen turbopump (HPOTP). Compliant foil bearing (CFB) manufacturers have proposed replacing turbopump REB's with CFB's CFB's work well in aircraft air cycle machines, auxiliary power units, and refrigeration compressors. In a CFB, the rotor only contracts the foil support structure during start up and shut down. CFB damping is higher than REB damping. However, the load capacity of the CFB is low, compared to a REB. Furthermore, little stiffness and damping data exists for the CFB. A rotordynamic analysis for turbomachinery critical speeds and stability requires the input of bearing stiffness and damping coefficients. The two basic types of CFB are the tension-dominated bearing and the bending-dominated bearing. Many investigators have analyzed and measured characteristics of tension-dominated foil bearings, which are applied principally in magnetic tape recording. The bending-dominated CFB is used more in rotating machinery. This report describes the first phase of a structural analysis of a bending-dominated, multileaf CFB. A brief discussion of CFB literature is followed by a description and results of the present analysis.

  4. Foil bearings

    Science.gov (United States)

    Elrod, David A.

    1993-01-01

    The rolling element bearings (REB's) which support many turbomachinery rotors offer high load capacity, low power requirements, and durability. Two disadvantages of REB's are: (1) rolling or sliding contact within the bearing has life-limiting consequences; and (2) REB's provide essentially no damping. The REB's in the Space Shuttle Main Engine (SSME) turbopumps must sustain high static and dynamic loads, at high speeds, with a cryogenic fluid as lubricant and coolant. The pump end ball bearings limit the life of the SSME high pressure oxygen turbopump (HPOTP). Compliant foil bearing (CFB) manufacturers have proposed replacing turbopump REB's with CFB's CFB's work well in aircraft air cycle machines, auxiliary power units, and refrigeration compressors. In a CFB, the rotor only contracts the foil support structure during start up and shut down. CFB damping is higher than REB damping. However, the load capacity of the CFB is low, compared to a REB. Furthermore, little stiffness and damping data exists for the CFB. A rotordynamic analysis for turbomachinery critical speeds and stability requires the input of bearing stiffness and damping coefficients. The two basic types of CFB are the tension-dominated bearing and the bending-dominated bearing. Many investigators have analyzed and measured characteristics of tension-dominated foil bearings, which are applied principally in magnetic tape recording. The bending-dominated CFB is used more in rotating machinery. This report describes the first phase of a structural analysis of a bending-dominated, multileaf CFB. A brief discussion of CFB literature is followed by a description and results of the present analysis.

  5. A Floral Fragrance, Methyl Benzoate, is An Efficient Green Pesticide

    Science.gov (United States)

    Feng, Yan; Zhang, Aijun

    2017-02-01

    Over-reliance on synthetic pesticides in insect pest control has caused widespread public and scientific concerns for human health and the environment, especially since many insect pests have already developed resistances to conventional pesticides and Bt products. For this reason, there is a considerable interest in development of alternative control methods for insect pest management. Based on laboratory studies, we report that methyl benzoate (MB), a naturally-occurring compound in many plants, may possess toxicity against various stages of a variety of insect pests, including the brown marmorated stinkbug, Halyomorpha halys, diamondback moth, Plutella xylostella, and tobacco hornworm, Manduca sexta, as well as the spotted wing drosophila, Drosophila suzukii. Based on our laboratory toxicity data, MB was at least 5 to 20 times more toxic than the conventional pyrethroid (β-cyfluthrin), sulfur & pyrethrin mixture, and some organic commercial products available on the market against H. halys, P. xylostella, and M. sexta, eggs. Because MB is considered an environment-friendly, it has great potential to be used as an alternative tool to synthetic pesticide for insect pest management in crop production, thereby, reducing threats to natural ecosystems and human health caused by over-application of conventional synthetic pesticides.

  6. Synthesis and structure of linear hexanuclear manganese (Ⅱ) benzoate cluster

    Institute of Scientific and Technical Information of China (English)

    陈昌能; 陈久桐; 朱红平; 黄子祥; 刘秋田

    2001-01-01

    From a reaction system including benzoic acid and Mn(NO3)2 in alkali medium, two hexanuclear manganese benzoate cluster compounds have been synthesized. A compound [Et4N]2[Mn6(PhCOO)14] has been structurally characterized, which contains hexanuclear Mn11 moieties extending unlimitedly to form one-dimensional linear structure. Carboxyl oxygen atoms are bridged in variety of modes to the Mn atoms, forming an arrangement like a sinusoid for the Mn atoms. The structural parameters of these compounds were compared with the data obtained from EXAFS determination for the Mn cluster in the OEC of PS11, supporting that the coordination sphere of the Mn site in the OEC may contain carboxyl bridges. The possible combination modes between the carboxyl group and the Mn atoms have been suggested. The NMR signals exhibit widening and shift produced by the influence of the paramagnetic Mn" sites. The red-shift of the absorption in IR spectrum was observed to be attributed to the coordination of the carboxyl group to the Mn

  7. Synthesis and structure of linear hexanuclear manganese (II) benzoate cluster

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    From a reaction system including benzoic acid and Mn(NO3)2 in alkali medium, two hexanuclear manganese benzoate cluster compounds have been synthesized. A compound [Et4N]2[Mn6(PhCOO)14] has been structurally characterized, which contains hexanuclear MnII moie-ties extending unlimitedly to form one-dimensional linear structure. Carboxyl oxygen atoms are bridged in variety of modes to the Mn atoms, forming an arrangement like a sinusoid for the Mn atoms. The structural parameters of these compounds were compared with the data obtained from EXAFS determination for the Mn cluster in the OEC of PSII, supporting that the coordination sphere of the Mn site in the OEC may contain carboxyl bridges. The possible combination modes between the carboxyl group and the Mn atoms have been suggested. The NMR signals exhibit widening and shift produced by the influence of the paramagnetic MnII sites. The red-shift of the absorption in IR spectrum was observed to be attributed to the coordination of the carboxyl group to the Mn atom, supporting the result of the study on crystal structure.

  8. Expression, purification and kinetic characterization of recombinant benzoate dioxygenase from Rhodococcus ruber UKMP-5M

    Directory of Open Access Journals (Sweden)

    Arezoo Tavakoli

    2016-09-01

    Full Text Available In this study, benzoate dioxygenase from Rhodococcus ruber UKMP-5M was catalyzed by oxidating the benzene ring to catechol and other derivatives. The benzoate dioxygenase (benA gene from Rhodococcus ruber UKMP-5M was then expressed, purified, characterized, The benA gene was amplified (642 bp, and the product was cloned into a pGEM-T vector.The recombinant plasmid pGEMT-benA was digested by double restriction enzymes BamHI and HindIII to construct plasmid pET28b-benA and was then ligated into Escherichia coli BL21 (DE3. The recombinant E. coli was induced with 0.5 mM isopropyl β-D-thiogalactoside (IPTG at 22˚C to produce benzoate dioxygenase. The enzyme was then purified by ion exchange chromatography after 8 purification folds. The resulting product was 25 kDa, determined by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE and western blotting. Benzoate dioxygenase activity was found to be 6.54 U/mL and the optimal pH and temperature were 8.5 and 25°C, respectively. Maximum velocity (Vmax and Michaelis constant (Km were 7.36 U/mL and 5.58 µM, respectively. The end metabolite from the benzoate dioxygenase reaction was cyclohexane dione, which was determined by gas chromatography mass spectrometry (GC-MS.

  9. Sodium benzoate and potassium sorbate preservatives in food stuffs in Iran.

    Science.gov (United States)

    Amirpour, Mansooreh; Arman, Azim; Yolmeh, Ahmad; Akbari Azam, Maryam; Moradi-Khatoonabadi, Zhila

    2015-01-01

    A high-performance liquid chromatography method was applied for the determination of the levels of benzoate and sorbate in 400 food samples, including pickled cucumbers, canned tomato pastes, sour cherry jams, soft drinks, fruit juices and dairy products (UF-Feta cheeses, Lighvan cheeses, lactic cheeses, yogurts and doogh). The results showed that 270 (67.5%) of all samples contained benzoate ranging from 11.9 to 288.5 mg kg(-1) in lactic cheese and fruit juice, respectively. The levels of sorbate in 98 (24.5%) of the samples were 20.1 to 284.3 mg kg(-1) in doogh and fruit juice, respectively. Moreover, benzoate was detected in all dairy products ranging from 11.9 mg kg(-1) in lactic cheese to 91.2 mg kg(-1) in UF-Feta cheese. A low concentration of benzoate could originate naturally, due to specific biochemical mechanisms during cheese, yogurt and doogh maturation. In conclusion, a minimum level for benzoate in dairy products should be defined in the legislation.

  10. Hydrodynamic bearings

    CERN Document Server

    Bonneau, Dominique; Souchet, Dominique

    2014-01-01

    This Series provides the necessary elements to the development and validation of numerical prediction models for hydrodynamic bearings. This book describes the rheological models and the equations of lubrication. It also presents the numerical approaches used to solve the above equations by finite differences, finite volumes and finite elements methods.

  11. Development and validation of UV spectrophotometric method to study stress degradation behaviour of rizatriptan benzoate.

    Science.gov (United States)

    Amolkumar, Kempwade; Ashok, Taranalli; Kiran, Jadhav

    2015-01-01

    Rizatriptan benzoate is a 5 HT 1B/1D receptor agonist which is prescribed for the treatment of migraine. In the present study new, simple, specific ultraviolet spectrophotometric method for rizatriptan benzoate was developed and validated. Forced degradation studies were carried out in acidic, alkaline and neutral pH conditions. The absorbance maxima peak was found to be 224 nm and linearity was observed in the concentration range of 0. 5-2. 5 µg . mL-1 with regression coefficient value of 0. 998 8. The method was validated and found to be precise. The percent recovery for rizatriptan benzoate was found to be 98. 576±0. 202. The bulk drug was found to be stable in neutral and acidic pH conditions but got degraded in 1 N NaOH solution.

  12. Development and Validation of UV Spectrophotometric Method to Study Stress Degradation Behaviour of Rizatriptan Benzoate

    Institute of Scientific and Technical Information of China (English)

    Kempwade Amolkumar; Taranalli Ashok; Jadhav Kiran

    2015-01-01

    Rizatriptan benzoate is a 5 HT 1B/1D receptor agonist which is prescribed for the treatment of mi-graine .In the present study new ,simple ,specific ultraviolet spectrophotometric method for rizatriptan benzo-ate was developed and validated .Forced degradation studies were carried out in acidic ,alkaline and neutral pH conditions .The absorbance maxima peak was found to be 224 nm and linearity was observed in the concentra-tion range of 0.5~2.5 μg・mL -1 with regression coefficient value of 0.998 8 .The method was validated and found to be precise .The percent recovery for rizatriptan benzoate was found to be 98.576 ± 0.202 .The bulk drug was found to be stable in neutral and acidic pH conditions but got degraded in 1 N NaOH solution .

  13. Development and Validation of HPTLC Method for the Estimation of Rizatriptan Benzoate in Bulk and Tablets.

    Science.gov (United States)

    Sundar, B Syama; Suneetha, A

    2010-11-01

    A new, simple high performance thin layer chromatographic method has been proposed for the determination of rizatriptan benzoate in a tablet dosage form. The drug was separated on aluminum plates precoated with silica gel 60 F(254) with dichloromethane-acetone-acetic acid 3:2:0.2(v/v/v) as mobilephase. Quantitative analysis was performed by densitometric scanning at 230 nm. The method was validated for linearity, accuracy, precision and robustness. The calibration plot was linear over the range 200-700 ng/band for rizatriptan benzoate. The method was successfully applied to the analysis of drug in bulk and marketed tablets.

  14. Toxic effects of pollutants on the Mineralization of 4-chlorophenol and Benzoate in methanogenic river sediment

    NARCIS (Netherlands)

    van Beelen P; van Vlaardingen PLA

    1993-01-01

    The toxic effects of pollutants on the mineralization of 2 mug/l [U-14C] 4-chlorophenol and benzoate were studied in microcosms with methanogenic sediment from the Rhine river. In contrast with studies using a high substrate concentration no lag time was observed and the half-lives for 4-chlorophen

  15. Identification of a Transcriptional Repressor Involved in Benzoate Metabolism in Geobacter bemidjiensis ▿

    OpenAIRE

    2011-01-01

    Subsurface environments contaminated with aromatic compounds can be remediated in situ by Geobacter species. A transcription factor that represses expression of bamA, a benzoate-inducible gene, in Geobacter bemidjiensis during growth with acetate was identified. It is likely that this repressor also regulates other genes involved in aromatic compound metabolism.

  16. An Overview on the Effects of Sodium Benzoate as a Preservative in Food Products

    Directory of Open Access Journals (Sweden)

    Shahmohammadi

    2016-05-01

    Full Text Available Context Food spoilage has been a common problem throughout history, and much of the spoilage is caused the activity of microorganisms or enzymatic reactions during the storage of food. Thus, using chemical substances could prevent or delay food spoilage and this has led to the great success of these compounds in the treatment of human diseases. Sodium benzoate is one of the synthetic additives that are widely used in the food industry. Evidence Acquisition In this review we summarized the history and role of benzoate sodium in the food industry, its limited value in different food, other uses, pharmacokinetics, and its toxicity in animal studies. A literature search was carried out using MEDLINE, Scopus, Science Direct, and Scientific Information Databases (SID. Results Sodium benzoate is used in different industries as well as the food industry and it has adverse effects similar to other food additives. Conclusions Studies on natural ingredients in foods to find compounds with similar effects as benzoate with less adverse effects is necessary.

  17. Regulation of expression of the Aspergillus niger benzoate para-hydroxylase cytochrome P450 system

    NARCIS (Netherlands)

    Brink, J.M. van den; Punt, P.J.; Gorcom, R.F.M. van; Hondel, C.A.M.J.J. van den

    2000-01-01

    Cytochrome P450 enzyme systems are found throughout nature and are involved in many different, often complex, bioconversions. In the endoplasmic reticulum of the filamentous fungus Aspergillus niger a cytochrome P450 enzyme system is present that is capable of the para-hydroxylation of benzoate. The

  18. Effects of sodium benzoate on storage stability of previously improved beverage from tamarind (Tamarindus indica L.).

    Science.gov (United States)

    Adeola, Abiodun A; Aworh, Ogugua C

    2014-01-01

    The effect of sodium benzoate on the quality attributes of improved tamarind beverage during storage was investigated. Tamarind beverages were produced according to a previously reported improved method, with or without chemical preservatives (100 mg/100 mL sodium benzoate). Tamarind beverage produced according to traditional processing method served as the control. The tamarind beverages were stored for 4 months at room (29 ± 2°C) and refrigerated (4-10°C) temperatures. Samples were analyzed, at regular intervals, for chemical, sensory, and microbiological qualities. Appearance of coliforms or overall acceptability score of 5.9 was used as deterioration index. The control beverages deteriorated by 2nd and 10th days at room and refrigerated temperatures, respectively. Improved tamarind beverage produced without the inclusion of sodium benzoate was stable for 3 and 5 weeks at room and refrigerated temperatures, respectively. Sodium benzoate extended the shelf life of the improved tamarind beverage to 6 and 13 weeks, respectively, at room and refrigerated temperatures.

  19. Ultrasound mediated alkaline hydrolysis of methyl benzoate – reinvestigation with crucial parameters

    NARCIS (Netherlands)

    Sivakumara, Manickam; Senthilkumar, Paramasivam; Majumdara, Sukti; Pandit, Aniruddha B.

    2002-01-01

    In the present work hydrolysis of methyl benzoate was carried out using aqueous sodium hydroxide solution at room temperature in the presence of ultrasound since otherwise the same reaction takes place at relatively high temperature. Also, the above hydrolysis reaction was investigated at a relative

  20. Photodegradation of emamectin benzoate and its influence on efficacy against the rice stem borer Chilo suppressalis

    Science.gov (United States)

    Emamectin benzoate is a novel insecticide with characteristics of translaminar movement into plant leaf tissue. The compound was derived from the avermectin family and improved with thermal stability, greater water solubility, and a broader spectrum of insecticidal activity than avermectin. To deter...

  1. Sodium Benzoate and Potassium Sorbate in Processed Meat Products Collected in Ho Chi Minh City, Vietnam

    Directory of Open Access Journals (Sweden)

    Yen T.H. Hoang

    2016-01-01

    Full Text Available Sodium benzoate and potassium sorbates are the two typical preservatives widely used in Vietnam and other countries. The maximum level (ML of sodium benzoate and potassium sorbate in processed meat products imposed by Ministry of Public Health is 1000 ppm. Although there are warnings about overusing of these preservatives that related to human health, many manufacturers do not follow the regulations. The aim of this study was to survey and consider the amounts and presence of these preservatives in processed meat products by using High-performance liquid chromatography (HPLC method. 90 samples of brands and no brands including Vietnamese pork rolls, pâtés, hams, sausages, and fermented pork rolls that available at markets in Ho Chi Minh City were analysed for these two preservatives. There was a preference for using sodium benzoate in all samples. Moreover, Vietnamese pork roll samples had the highest percentage of samples with preservatives concentrations exceeding the ML. Among 90 samples, sodium benzoate was detected in 52.2% of samples and 17.8% of them exceeded the ML, while potassium sorbate was found in 24.4% of samples and only 2.2% of them exceeded the regulated amount. 46.4% of Vietnamese pork rolls, 12.5% of pâtés, and 9.1% of fermented pork rolls had sodium benzoate exceeded the ML, whilst ham and sausage samples contained the concentrations inside the safety limits. Furthermore, only one sample of Vietnamese pork rolls and one sample of sausages had potassium sorbate concentrations surpassing the ML with the level of 1,717.57 mg/kg and 1,814.00 mg/kg, respectively. Furthermore, branded samples showed a significantly different result in compared with no branded samples. Of branded samples, exceeding sodium benzoate level ML was detected in 10% of samples and none of the samples found surpassing potassium sorbate limit amount. Nevertheless, 27.5% and 5% of unbranded samples had sodium benzoate and potassium sorbate higher than

  2. Effect of sodium benzoate preservative on micronucleus induction, chromosome break, and Ala40Thr superoxide dismutase gene mutation in lymphocytes.

    Science.gov (United States)

    Pongsavee, Malinee

    2015-01-01

    Sodium benzoate is food preservative that inhibits microbial growth. The effects of sodium benzoate preservative on micronucleus induction, chromosome break, and Ala40Thr superoxide dismutase gene mutation in lymphocytes were studied. Sodium benzoate concentrations of 0.5, 1.0, 1.5, and 2.0 mg/mL were treated in lymphocyte cell line for 24 and 48 hrs, respectively. Micronucleus test, standard chromosome culture technique, PCR, and automated sequencing technique were done to detect micronucleus, chromosome break, and gene mutation. The results showed that, at 24- and 48-hour. incubation time, sodium benzoate concentrations of 1.0, 1.5, and 2.0 mg/mL increased micronucleus formation when comparing with the control group (P sodium benzoate concentrations of 2.0 mg/mL increased chromosome break when comparing with the control group (P Sodium benzoate did not cause Ala40Thr (GCG→ACG) in superoxide dismutase gene. Sodium benzoate had the mutagenic and cytotoxic toxicity in lymphocytes caused by micronucleus formation and chromosome break.

  3. Effect of Sodium Benzoate Preservative on Micronucleus Induction, Chromosome Break, and Ala40Thr Superoxide Dismutase Gene Mutation in Lymphocytes

    Directory of Open Access Journals (Sweden)

    Malinee Pongsavee

    2015-01-01

    Full Text Available Sodium benzoate is food preservative that inhibits microbial growth. The effects of sodium benzoate preservative on micronucleus induction, chromosome break, and Ala40Thr superoxide dismutase gene mutation in lymphocytes were studied. Sodium benzoate concentrations of 0.5, 1.0, 1.5, and 2.0 mg/mL were treated in lymphocyte cell line for 24 and 48 hrs, respectively. Micronucleus test, standard chromosome culture technique, PCR, and automated sequencing technique were done to detect micronucleus, chromosome break, and gene mutation. The results showed that, at 24- and 48-hour. incubation time, sodium benzoate concentrations of 1.0, 1.5, and 2.0 mg/mL increased micronucleus formation when comparing with the control group (P<0.05. At 24- and 48-hour. incubation time, sodium benzoate concentrations of 2.0 mg/mL increased chromosome break when comparing with the control group (P<0.05. Sodium benzoate did not cause Ala40Thr (GCG→ACG in superoxide dismutase gene. Sodium benzoate had the mutagenic and cytotoxic toxicity in lymphocytes caused by micronucleus formation and chromosome break.

  4. Investigation of comparative efficacy of eugenol and benzyl benzoate in therapy of sheep mange

    Directory of Open Access Journals (Sweden)

    Jezdimirović Milanka

    2010-01-01

    Full Text Available The acaricide efficacy, tolerance and safety of eugenol (10 and 20 % in the treatment of sarcoptic mange in sheep have been investigated. The results were compared with those corresponding for benzyl benzoate (25 %, which was applied to sheep in the same way. The treatment was applied on sheep three times in one-week intervals. Skin scrapings were sampled seven days after each treatment, as well as twenty-eight days following the third one. The changes on the skin were quantified and the mean recovery response (MRR was calculated. The clinical efficacy was assessed according to the MRR and the number of mites in the samples. Following the first treatment 10%eugenol was not significantly less efficacious in comparison with the higher concentration. Having been applied twice 20% eugenol was significantly more efficacious when compared to the lower concentration, which remained the same seven and twenty-eight days after the third application. The efficacy of 10% eugenol in the therapy of mange was significantly higher in comparison with benzyl benzoate following one, two or three administrations. The efficacy of benzyl benzoate four weeks after the third treatment was still significantly lower in comparison with 10% eugenol. The efficacy of 20% eugenol was significantly higher in comparison with its lower concentration as well as that of benzyl benzoate, following the second, and seven and twenty-eight days after the third one. No signs of local or systemic intolerance were observed in sheep treated with either 10 or 20% eugenol, or 25 % benzyl benzoate. .

  5. THERMAL DECOMPOSITION MECHANISM OF BARIUM BENZOATE%苯甲酸钡的热分解机理

    Institute of Scientific and Technical Information of China (English)

    张克立; 袁继兵; 袁良杰; 孙聚堂

    1999-01-01

    Barium benzoate was synthesized in semi-solid phase reaction. The complex was characterized by elemental analysis, IR, X-ray powder diffraction. It is layered structure, monoclinic system. The mechanism of thermal decomposition for barium benzoate was studied by using TG, DTA, IR and gas chromatography-mass spectrometer. The thermal decompositon of barium benzoate in nitrogen proceeded in one stage: it decomposed to form BaCO3 and organic compounds. The organic compounds obtained from decomposition reaction are mainly benzophenone, triphenylmethane and so on.

  6. Investigation of low levels of plasma valproic acid concentration following simultaneous administration of sodium valproate and rizatriptan benzoate.

    Science.gov (United States)

    Hokama, Nobuo; Hobara, Norio; Kameya, Hiromasa; Ohshiro, Susumu; Hobara, Narumi; Sakanashi, Matao

    2007-03-01

    Drug interaction between rizatriptan benzoate, an anti-migraine agent, and sodium valproate (VPA-Na), an anticonvulsant, was studied in rats. When rizatriptan benzoate was administered orally immediately after VPA-Na oral administration, the pharmacokinetic parameters, such as plasma valproic acid (VPA) and area under the plasma concentration-time curve up to 3 h (AUC(0-3)), were significantly decreased compared with those in the control group. However, when rizatriptan benzoate was administered intraperitoneally immediately after VPA-Na orally, these parameters were not changed. In addition, when benzoic acid was administered orally immediately after VPA-Na orally, these were significantly lower compared with the control values. Therefore, it might be possible that VPA transport by monocarboxylate transporter was competitively inhibited by rizatriptan benzoate and thus absorption of VPA was decreased.

  7. Identification of anthranilate and benzoate metabolic operons of Pseudomonas fluorescens and functional characterization of their promoter regions

    Directory of Open Access Journals (Sweden)

    Lee Vincent D

    2006-01-01

    Full Text Available Abstract Background In an effort to identify alternate recombinant gene expression systems in Pseudomonas fluorescens, we identified genes encoding two native metabolic pathways that were inducible with inexpensive compounds: the anthranilate operon (antABC and the benzoate operon (benABCD. Results The antABC and benABCD operons were identified by homology to the Acinetobacter sp. anthranilate operon and Pseudomonas putida benzoate operon, and were confirmed to be regulated by anthranilate or benzoate, respectively. Fusions of the putative promoter regions to the E. coli lacZ gene were constructed to confirm inducible gene expression. Each operon was found to be controlled by an AraC family transcriptional activator, located immediately upstream of the first structural gene in each respective operon (antR or benR. Conclusion We have found the anthranilate and benzoate promoters to be useful for tightly controlling recombinant gene expression at both small (

  8. Development and evaluation of tamarind seed xyloglucan-based mucoadhesive buccal films of rizatriptan benzoate.

    Science.gov (United States)

    Avachat, Amelia M; Gujar, Kishore N; Wagh, Kishor V

    2013-01-16

    Mucoadhesive buccal films were developed using tamarind seed xyloglucan (TSX) as novel mucoadhesive polysaccharide polymer for systemic delivery of rizatriptan benzoate through buccal route. Formulations were prepared based on 3(2) factorial design with concentrations of TSX and carbopol 934P (CP) as independent variables. Three dependent variables considered were tensile strength, bioadhesion force and drug release. DSC analysis revealed no interaction between drug and polymers. Ex vivo diffusion studies were carried out using Franz diffusion cell, while bioadhesive properties were evaluated using texture analyzer with porcine buccal mucosa as model tissue. Results revealed that bilayer film containing 4% (w/v) TSX and 0.5% (w/v) CP in the drug layer and 1% (w/v) ethyl cellulose in backing layer demonstrated diffusion of 93.45% through the porcine buccal mucosa. Thus, this study suggests that tamarind seed polysaccharide can act as a potential mucoadhesive polymer for buccal delivery of a highly soluble drug like rizatriptan benzoate.

  9. Comparison of ivermectin and benzyl benzoate lotion for scabies in Nigerian patients.

    Science.gov (United States)

    Sule, Halima M; Thacher, Tom D

    2007-02-01

    Few studies have compared ivermectin directly with topical agents in developing countries. We compared the effectiveness of oral ivermectin (200 microg/kg) with topical 25% benzyl benzoate and monosulfiram soap in 210 subjects of age 5 to 65 years with scabies. Subjects with persistent lesions after 2 weeks received a second course of treatment. All lesions had resolved after 2 weeks in 77 of 98 (79%) subjects treated with ivermectin and in 60 of 102 (59%) subjects treated topically (P = 0.003). The improvement in severity score was greater in the ivermectin group than in the topical treatment group (P topical treatment group (P = 0.04). Compared with topical benzyl benzoate and monosulfiram in the treatment of scabies, ivermectin was at least as effective and led to more rapid improvement.

  10. Growth and studies of cyclohexylammonium 4-methoxy benzoate single crystal for nonlinear optical applications

    Science.gov (United States)

    Sathya, P.; Gopalakrishnan, R.

    2015-06-01

    Cyclohexylammonium 4-Methoxy Benzoate (C4MB) was synthesised and the functional groups were confirmed by FTIR analysis. The purified C4MB (by repeated recrystallisation) was used for single crystal growth. Single crystal of cyclohexylammonium 4-methoxy benzoate was successfully grown by slow evaporation solution growth method at ambient temperature. Structural orientations were determined from single crystal X-ray diffractometer. Optical absorption and cut off wavelength were identified by UV-Visible spectroscopy. Thermal stability of the crystal was studied from thermogravimetric and differential thermal analyses curves. Mechanical stability of the grown crystal was analysed by Vicker's microhardness tester. The Second Harmonic Generation (SHG) study revealed that the C4MB compound exhibits the SHG efficiency 3.3 times greater than KDP crystal.

  11. Growth and studies of cyclohexylammonium 4-methoxy benzoate single crystal for nonlinear optical applications

    Energy Technology Data Exchange (ETDEWEB)

    Sathya, P.; Gopalakrishnan, R., E-mail: krgkrishnan@annauniv.edu [Crystal Research Lab, Department of Physics, Anna University, Chennai-600002 (India)

    2015-06-24

    Cyclohexylammonium 4-Methoxy Benzoate (C4MB) was synthesised and the functional groups were confirmed by FTIR analysis. The purified C4MB (by repeated recrystallisation) was used for single crystal growth. Single crystal of cyclohexylammonium 4-methoxy benzoate was successfully grown by slow evaporation solution growth method at ambient temperature. Structural orientations were determined from single crystal X-ray diffractometer. Optical absorption and cut off wavelength were identified by UV-Visible spectroscopy. Thermal stability of the crystal was studied from thermogravimetric and differential thermal analyses curves. Mechanical stability of the grown crystal was analysed by Vicker’s microhardness tester. The Second Harmonic Generation (SHG) study revealed that the C4MB compound exhibits the SHG efficiency 3.3 times greater than KDP crystal.

  12. An Overview on the Effects of Sodium Benzoate as a Preservative in Food Products

    OpenAIRE

    Shahmohammadi; Javadi; Nassiri-Asl

    2016-01-01

    Context Food spoilage has been a common problem throughout history, and much of the spoilage is caused the activity of microorganisms or enzymatic reactions during the storage of food. Thus, using chemical substances could prevent or delay food spoilage and this has led to the great success of these compounds in the treatment of human diseases. Sodium benzoate is one of the synthetic additives that are widely used in the food industry. Evidenc...

  13. Bacterial degradation of benzoate: cross-regulation between aerobic and anaerobic pathways

    OpenAIRE

    2012-01-01

    We have studied for the first time the transcriptional regulatory circuit that controls the expression of the box genes encoding the aerobic hybrid pathway used to assimilate benzoate via coenzyme A (CoA) derivatives in bacteria. The promoters responsible for the expression of the box cluster in the β-proteobacterium Azoarcus sp., their cognate transcriptional repressor, the BoxR protein, and the inducer molecule (benzoyl-CoA) have been characterized. The BoxR protein shows a significant sequ...

  14. Simultaneous determination of a quaternary mixture of oxomemazine, sodium benzoate, guaifenesin and paracetamol by chromatographic methods

    OpenAIRE

    Nehal F. Farid; Nariman A. El Ragehy; Maha A. Hegazy; Mohamed Abdelkawy; Fadia H. Metwally

    2014-01-01

    The aim of the present work was to develop simple, accurate, sensitive and selective methods for the simultaneous determination of oxomemazine (Ox), sodium benzoate (SB), guaifenesin (Gu), andparacetamol (Par). Two methods were described and validated for the simultaneous determination of the four drugs in syrup and suppositories. The first method was a reversed phase HPLC and UVdetection at 220 nm. The assay was performed using C 18 column and an isocratic elution using acetonitrile – methan...

  15. Development and validation of a specific stability indicating high performance liquid chromatographic method for rizatriptan benzoate.

    Science.gov (United States)

    Mallikarjuna Rao, B; Sangaraju, Sivaiah; Srinivasu, M K; Madhavan, P; Lalitha Devi, M; Rajendra Kumar, P; Chandrasekhar, K B; Arpitha, Ch; Satya Balaji, T

    2006-06-16

    A gradient, reversed-phase liquid chromatographic (RP-LC) method was developed for the quantitative determination of rizatriptan benzoate, used to treat relieves migraine headache symptoms. The developed method can be also employed for the related substance determination in bulk samples. Forced degradation studies were performed on bulk sample of rizatriptan benzoate using acid (0.5 N hydrochloric acid), base (0.1 N sodium hydroxide), oxidation (3.0% hydrogen peroxide), water hydrolysis, heat (60 degrees C) and photolytic degradation. Mild degradation of the drug substance was observed in base hydrolysis and considerable degradation observed during oxidative stress. The chromatographic method was fine tuned using the samples generated from forced degradation studies. Good resolution between the peaks corresponds to degradation products and the analyte was achieved on Agilent Zorbax SB-CN (250 mm x 4.6 mm, 5 microm) column. The mobile phase consists of a mixture of aqueous potassium di hydrogen ortho phosphate (pH 3.4), acetonitrile and methanol. The stress sample solutions were assayed against the qualified reference standard of rizatriptan benzoate and the mass balance in each case was close to 99.7% indicating that the developed method is stability indicating. Validation of the developed method was carried out as per ICH requirements.

  16. Bioavailability Enhancement of Rizatriptan Benzoate by Oral Disintegrating Strip: In vitro and In vivo Evaluation.

    Science.gov (United States)

    Bhagawati, S T; Chonkar, Ankita D; Dengale, Swapnil J; Reddy, Sreenivasa M; Bhat, Krishnamurthy

    2016-01-01

    Oral disintegrating strips containing rizatriptan benzoate, a selective 5-hydroxy tryptamine receptor agonist with anti migraine property, was developed using polyvinyl alcohol, sodium alginate and hydroxyl propyl methylcellulose as the base materials. The analytical and bioanalytical methods were developed and validated using HPLC (PDA and flouroscence detectors). The dissolution study performed on the strips revealed that all the five formulations, release the drug within eight minutes. Under ICH accelerated stability conditions, strips were stable at 40°C and 75% humidity for eight weeks. Furthermore, pharmacokinetic properties of oral strip were compared with rizatriptan benzoate marketed tablet. Oral disintegrating strip and tablet showed significantly higher bioavailability. Oral strip exhibited better pharmacokinetic parameters than rizatriptan marketed tablet. The Tmax, Cmax, AUC and t1/2 for oral strip were found to be 1.00 h, 64.13±19.46 ng/mL, 352.00±71.57 ng/mL/h and 3.09±1.03 h respectively, whereas, tablet showed 1.5 h, 38.00±13.43 ng/mL, 210.38± 40.37ng/mL/h and 1.66±0.31 h respectively. These findings confirm that the rizatriptan benzoate oral disintegrating strip is potentially a useful tool for an effective treatment of migraine with improved bioavailability, rapid onset of action and with increased patient compliance.

  17. Synthesis, structure and some properties of a manganese(II) benzoate containing diimine

    Science.gov (United States)

    Paul, Pranajit; Roy, Subhadip; Sarkar, Sanjoy; Chowdhury, Shubhamoy; Purkayastha, R. N. Dutta; Raghavaiah, Pallepogu; McArdle, Patrick; Deb, Lokesh; Devi, Sarangthem Indira

    2015-12-01

    A new monomeric manganese(II) benzoate complex containing nitrogen donor 2,2‧-bipyridine, [Mn(OBz)2(bipy)(H2O)] (OBz = benzoate, bipy = 2,2‧-bipyridine) has been synthesized from aqueous methanol medium and characterized by analytical, spectroscopic and single crystal X-ray diffraction studies. The compound exhibits moderate to appreciable antimicrobial activity. The complex crystallizes in space group P21/n. Mn(II) atom is ligated by two N atoms of bipyridine, three O atoms from a monodentate and a bidentate benzoate ligand and a water molecule forming distorted octahedral structure. The coordinated water molecule forms intramolecular hydrogen bonds and links the monomer molecules into hydrogen bonded dimer. The hydrogen bonded dimers are involved in intermolecular C-H···O and π-π stacking interactions. Density functional theory (DFT) computation was carried out to compute the frequencies of relevant vibrational modes and electronic properties, the results are in compliance with the experimentally obtained structural and spectral data.

  18. Identification of bacteria utilizing biphenyl, benzoate, and naphthalene in long-term contaminated soil.

    Directory of Open Access Journals (Sweden)

    Ondrej Uhlik

    Full Text Available Bacteria were identified associated with biodegradation of aromatic pollutants biphenyl, benzoate, and naphthalene in a long-term polychlorinated biphenyl- and polyaromatic hydrocarbon-contaminated soil. In order to avoid biases of culture-based approaches, stable isotope probing was applied in combination with sequence analysis of 16 S rRNA gene pyrotags amplified from (13C-enriched DNA fractions. Special attention was paid to pyrosequencing data analysis in order to eliminate the errors caused by either generation of amplicons (random errors caused by DNA polymerase, formation of chimeric sequences or sequencing itself. Therefore, sample DNA was amplified, sequenced, and analyzed along with the DNA of a mock community constructed out of 8 bacterial strains. This warranted that appropriate tools and parameters were chosen for sequence data processing. (13C-labeled metagenomes isolated after the incubation of soil samples with all three studied aromatics were largely dominated by Proteobacteria, namely sequences clustering with the genera Rhodanobacter Burkholderia, Pandoraea, Dyella as well as some Rudaea- and Skermanella-related ones. Pseudomonads were mostly labeled by (13C from naphthalene and benzoate. The results of this study show that many biphenyl/benzoate-assimilating bacteria derive carbon also from naphthalene, pointing out broader biodegradation abilities of some soil microbiota. The results also demonstrate that, in addition to traditionally isolated genera of degradative bacteria, yet-to-be cultured bacteria are important players in bioremediation. Overall, the study contributes to our understanding of biodegradation processes in contaminated soil. At the same time our results show the importance of sequencing and analyzing a mock community in order to more correctly process and analyze sequence data.

  19. Ultrasonic Investigations of Molecular Interaction in Binary Mixtures of Benzyl Benzoate with Acetonitrile and Benzonitrile

    Directory of Open Access Journals (Sweden)

    N. Jaya Madhuri

    2011-01-01

    Full Text Available Ultrasonic velocity, density and viscosity have been measured in the binary mixtures of benzyl benzoate with acetonitrile, benzonitrile at three temperatures 30, 40 and 50 °C. From the experimental data, thermodynamic parameters like adiabatic compressibility, internal pressure, enthalpy, activation energy etc., were computed and the molecular interactions were predicted based on the variation of excess parameters in the mixture. Also theoretical evaluation of velocities was made employing the standard theories. CFT and NOMOTO were found to have an edge. All the three mixtures have shown out strong intermolecular interactions between the unlike molecules and endothermic type of chemical reaction.

  20. Two new terpenoid benzoates with antitumor activity from the roots of Ferula dissecta.

    Science.gov (United States)

    Huang, Jian; Han, Hong-Ying; Li, Guo-Yu; Wang, Hang-Yu; Zhang, Cui; Zhang, Ke; Tan, Yong; Li, Ping-Ya; Wang, Jin-Hui

    2013-01-01

    Two new sesquiterpene benzoates, syreiteate A (1) and syreiteate B (2), were isolated from the roots of Ferula dissecta (Ledeb.) Ledeb. Their structures were elucidated by extensive spectroscopic methods including 1D ((1)H and (13)C) NMR, 2D (HSQC, HMBC, DQF-COSY, and NOESY) NMR, and ESI-TOF-MS. Their configurations were determined on the basis of the analysis of the coupling constants, NOESY correlations, and circular dichroism spectrum. Compounds 1 and 2 showed potent growth inhibitory activity against cervical cancer HeLa cell line with the IC50 values of 13.2 and 19.3 μM, respectively.

  1. Application of N-succinimidyl 4-[18F](fluoromethyl) benzoate to protein labeling

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    N-succinimidyl 4-[18F](fluoromethyl) benzoate for protein labeling was prepared (57%, EOB) in about 30min. Reaction conditions of S18FMB with IgG including pH of solutions, protein concentration, reaction temperature and time were studied. The optimal labeling conditions were: 0.2mg/mL IgG, pH = 7.8-8.5, 25℃, and reaction time 5min.Under these conditions the yield was about 80%. The 18F-labeled protein was purified by size exclusion chromatography.

  2. Unexpected red shift of C-H vibrational band of Methyl benzoate

    CERN Document Server

    Maiti, Kiran Sankar; Scheurer, Christoph

    2016-01-01

    The C-H vibrational bands become more and more important in the structural determination of biological molecules with the development of CARS microscopy and 2DIR spectroscopy. Due to the congested pattern, near degeneracy, and strong anharmonicity of the C-H stretch vibrations, assignment of the C-H vibrational bands are often misleading. Anharmonic vibrational spectra calculation with multidimensional potential energy surface interprets the C-H vibrational spectra more accurately. In this article we have presented the importance of multidimensional potential energy surface in anharmonic vibrational spectra calculation and discuss the unexpected red shift of C-H vibrational band of Methyl benzoate.

  3. The Electrical Properties for Phenolic Isocyanate-Modified Bisphenol-Based Epoxy Resins Comprising Benzoate Group.

    Science.gov (United States)

    Lee, Eun Yong; Chae, Il Seok; Park, Dongkyung; Suh, Hongsuk; Kang, Sang Wook

    2016-03-01

    Epoxy resin has been required to have a low dielectric constant (D(k)), low dissipation factor (Df), low coefficient of thermal expansion (CTE), low water absorption, high mechanical, and high adhesion properties for various applications. A series of novel phenolic isocyanate-modified bisphenol-based epoxy resins comprising benzoate group were prepared for practical electronic packaging applications. The developed epoxy resins showed highly reduced dielectric constants (D(k)-3.00 at 1 GHz) and low dissipation values (Df-0.014 at 1 GHz) as well as enhanced thermal properties.

  4. Airborne contact urticaria due to sodium benzoate in a pharmaceutical manufacturing plant

    Energy Technology Data Exchange (ETDEWEB)

    Nethercott, J.R.; Lawrence, M.J.; Roy, A.M.; Gibson, B.L.

    1984-10-01

    Three workers exposed to airborne contact with sodium benzoate (SB) in a pharmaceutical plant developed transient urticaria related to skin contamination with SB. Patch test responses to SB and benzoic acid (BA), without occlusion, were similar to those of three previously unexposed controls in keeping with the nonimmunologic nature of the reaction. Sweating, which lowers skin pH and increases topical BA concentration, appeared to increase the susceptibility to urticaria in two of the three workers. Ventilation and hygiene control methods designed to reduce SB skin contamination eliminated the problem in the workplace. 10 references, 1 table.

  5. STUDY ON THE THERMODYNAMIC PROPERTIES OF ADSORPTION OF ETHYL BENZOATE AND DIETHYL PHTHALATE BY PHENOLIC RESIN ADSORBENTS

    Institute of Scientific and Technical Information of China (English)

    Zhong Wang; Zuo-qing Shi; Rong-fu Shi; Yun-ge Fan; Yi-zhong Yang

    2004-01-01

    This paper presents experimental observations on the adsorption of individual solutes by a simple thermodynamic framework, and the equilibrium adsorption of ethyl benzoate and diethyl phthalate on phenolic resin adsorbent in hexane solutions within the temperature range of 293-313 K. The experimental results show that the Freundlich adsorption law is applicable to the adsorption of ethyl benzoate and diethyl phthalate on the adsorbent, since all the correlative factors R' are larger than 0.99. The negative values of all the isosteric adsorption enthalpies for ethyl benzoate and diethyl phthalate indicate that they undergo exothermic processes, while their magnitudes (19-28 kJ/mol) manifest a hydrogen bonding sorption process. Other thermodynamic properties: the free energy changes and the entropy change associated with the adsorption have been calculated from the Gibbs adsorption equation and the Gibbs-Helmholtz equation.

  6. PH-stat fed-batch process to enhance the production of cis, cis-muconate from benzoate by Pseudomonas putida KT2440-JD1

    NARCIS (Netherlands)

    Duuren, J.B.J.H. van; Wijte, D.; Karge, B.; Martins dos Santos, V.A.; Yang, Y.; Mars, A.E.; Eggink, G.

    2012-01-01

    Pseudomonas putida KT2440-JD1 is able to cometabolize benzoate to cis, cis-muconate in the presence of glucose as growth substrate. P. putida KT2440-JD1 was unable to grow in the presence of concentrations above 50 mM benzoate or 600 mM cis, cis-muconate. The inhibitory effects of both compounds wer

  7. Generation of a catR deficient mutant of P. putida KT2440 that produces cis, cis-muconate from benzoate at high rate and yield

    NARCIS (Netherlands)

    Duuren, J.B.J.H. van; Wijte, D.; Leprince, A.; Karge, B.; Puchalka, J.; Wery, J.; Dos Santos, V.A.P.M.; Eggink, G.; Mars, A.E.

    2011-01-01

    Pseudomonas putida KT2440-JD1 was derived from P. putida KT2440 after N-methyl-N'-nitro-N-nitrosoguanidine (NTG)-mutagenesis and exposure to 3-fluorobenzoate (3-FB). The mutant was no longer able to grow using benzoate as a sole carbon source, but co-metabolized benzoate to cis, cis-muconate during

  8. Thermodynamic and Acoustic Study on Molecular Interactions in Certain Binary Liquid Systems Involving Ethyl Benzoate

    Directory of Open Access Journals (Sweden)

    B. Nagarjun

    2013-01-01

    Full Text Available Speeds of sound and density for binary mixtures of ethyl benzoate (EB with N,N-dimethylformamide (NNDMF, N,N-dimethyl acetamide (NNDMAc, and N,N-dimethylaniline (NNDMA were measured as a function of mole fraction at temperatures 303.15, 308.15 K, 313.15 K, and 318.15 K and atmospheric pressure. From the experimental data, adiabatic compressibility (βad, intermolecular free length (Lf, and molar volume (V have been computed. The excess values of the above parameters were also evaluated and discussed in light of molecular interactions. Deviation in adiabatic compressibilities and excess intermolecular free length (LfE are found to be negative over the molefraction of ethyl benzoate indicating the presence of strong interactions between the molecules. The negative excess molar volume VE values are attributed to strong dipole-dipole interactions between unlike molecules in the mixtures. The binary data of Δβad, VE, and LfE were correlated as a function of molefraction by using the Redlich-Kister equation.

  9. Development and preventative effect against pine wilt disease of a novel liquid formulation of emamectin benzoate.

    Science.gov (United States)

    Takai, Kazuya; Suzuki, Toshio; Kawazu, Kazuyoshi

    2003-03-01

    Injection of the poorly water-soluble emamectin benzoate (EB) into pine trunks required the development of an efficient liquid formulation. For injection into big trees in forests a good rate of injection and a high active content were required. Tests on the viscosity and EB-solubilizing ability of 14 various solubilizers in diethylene glycol monobutyl ether (DGMBE) led to the selection of Sorpol SM-100PM as the solubilizer of the formulation. Relationships between the solubilizing ability and amounts of Sorpol SM-100PM and DGMBE relative to that of EB, and between the concentration of the latter and the viscosity or the injection rate of the formulation led to a novel 40 g litre(-1) emamectin benzoate formulation (Shot Wan Liquid Formulation), which was composed of EB (40), Sorpol SM-100PM (120), DGMBE (160) and distilled water (50 g litre(-1)) in methanol. Injection of this formulation at a dose of 10 g EB per unit volume of pine tree prevented over 90% of the trees from wilting caused by pine wood nematode, and this preventative effect continued for 3 years. Neither discolouration of the leaves nor injury around the injection hole on the trees was observed after injection of the formulation.

  10. Simultaneous Determination of Potassium Sorbate and Sodium Benzoate in Doogh Using High Performance Liquid Chromatography

    Directory of Open Access Journals (Sweden)

    S. Sohrabvandi

    2015-09-01

    Full Text Available In this research, high performance liquid chromatography (HPLC as a simple and rapid technique was used for the determination of potassium sorbate and sodium benzoate in different brands of Doogh (typical Iranian drink based on fermented milk. The chromatographic separation was achieved with a C18 column (250 mm×4 I.D, 5 µm and one buffered mobile phase, acetate buffer (0.2 mol/L, pH4.4: acetonitrile (63:37 at a flow rate of 1 mL/min. The effluent was monitored at 235nm, respectively. The main affecting factors, such as Carrez solution amount, pH and centrifuge speed were optimized. Limits of detection (LODs were 1.823 for sorbic acid and 1.985 for benzoic acid. Relative standard deviations (RSDs for quintuplicate analyses were 4.4 for sorbic acid and 4.087 for benzoic acid. The method also showed good linearity in a range from 4 to 1000 mg/L with correlation coefficients (R2 of 0.990 for sorbic acid and 0.995 for benzoic acid. Recoveries for the two analytes were 80 for sorbic acid and 65 for benzoic acid. Comparing to the other techniques, the proposed method was significantly less time-consuming and had more acceptable accuracy, precision and interruption elimination in samples. The developed method was successfully used for the routine monitoring of benzoate and sorbate in Doogh.

  11. Secondary. cap alpha. -deuterium kinetic isotope effects in solvolyses of ferrocenylmethyl acetate and benzoate in ethanol

    Energy Technology Data Exchange (ETDEWEB)

    Sutic, D. (Univ. of Zagreb, Yugoslavia); Asperger, S.; Borcic, S.

    1982-12-17

    Secondary ..cap alpha..-deuterium kinetic isotope effects (KIE) in solvolyses of ferrocenyldideuteriomethyl acetate and benzoate were determined in 96% (v/v) ethanol, at 25/sup 0/C, as k/sub H//k/sub D/ = 1.24 and 1.26, respectively. The KIEs were also determined in the presence of 0.1 mol dm/sup -3/ lithium perchlorate: the k/sub H//k/ sub D/ values were 1.23 and 1.22 for acetate and benzoate complexes, respectively. The maximum KIE for the C-O bond cleavage of a primary substrate is as large as, or larger than, that of secondary derivatives, which is estimated to be 1.23 per deuterium. The measured KIE of about 12% per D therefore represents a strongly reduced effect relative to its maximum. The solvolyses exhibit ''a special salt effect''. This effect indicates the presence of solvent-separated ion pairs and the return to tight pairs. As the maximum KIE is expected in solvolyses involving transformation of one type of ion pair into another, the strongly reduced ..cap alpha..-D KIE supports the structure involving direct participation of electrons that in the ground state are localized at the iron atom. The alkyl-oxygen cleavage is accompanied by 10-15% acyl-oxygen cleavage.

  12. Formulation and evaluation of fast dissolving sublingual films of Rizatriptan Benzoate

    Directory of Open Access Journals (Sweden)

    Bhyan Bhupinder

    2012-03-01

    Full Text Available Rizatriptan Benzoate, a serotonin 5-HT1 receptor agonist is a new generation antimigraine drug which has oral bioavailability of 47% due to hepatic first pass metabolism. The present study investigated the possibility of developing Rizatriptan benzoate fast dissolving sublingual films allowing fast, reproducible drug dissolution in the oral cavity, thus bypassing first pass metabolism to provide rapid onset of action of the drug. The fast dissolving films were prepared by solvent casting method. Low viscosity grade of hydroxylpropyl methylcellulose (HPMC E 15 and maltodextrin were used in combination as film forming polymer, due to their hydrophilic nature and palatable taste. To decrease the disintegration time of formulations sodium starch glycolate was used as disintegrating agent. Glycerol, mannitol, aspartame and sodium lauryl sulphate were used as a cooling agent, sweetening agent and oral penetration enhancer respectively. All the films formulations (F1-F8 was evaluated for their thickness, weight variations, tensile strength, percentage elongation, folding endurance, surface pH, in-vitro disintegration, drug content, in-vitro drug release and ex-vivo permeation. Disintegration time showed by the formulations was found to be in range of 25-50 sec. Formulations F1 and F2 showed 90% in-vitro drug release within 7 min and 61% ex-vivo drug permeation within16 min. The film showed an excellent stability at least for 4 weeks when stored at 400 C and 75% in humidity.

  13. Cryogenic Hybrid Magnetic Bearing

    Science.gov (United States)

    Meeks, Crawford R.; Dirusso, Eliseo; Brown, Gerald V.

    1994-01-01

    Cryogenic hybrid magnetic bearing is example of class of magnetic bearings in which permanent magnets and electromagnets used to suspend shafts. Electromagnets provide active control of position of shaft. Bearing operates at temperatures from -320 degrees F (-196 degrees C) to 650 degrees F (343 degrees C); designed for possible use in rocket-engine turbopumps, where effects of cryogenic environment and fluid severely limit lubrication of conventional ball bearings. This and similar bearings also suitable for terrestrial rotating machinery; for example, gas-turbine engines, high-vacuum pumps, canned pumps, precise gimbals that suspend sensors, and pumps that handle corrosive or gritty fluids.

  14. TOPICAL REVIEW: Superconducting bearings

    Science.gov (United States)

    Hull, John R.

    2000-02-01

    The physics and technology of superconducting bearings is reviewed. Particular attention is given to the use of high-temperature superconductors (HTSs) in rotating bearings. The basic phenomenology of levitational forces is presented, followed by a brief discussion of the theoretical models that can be used for conceptual understanding and calculations. The merits of various HTS bearing designs are presented, and the behaviour of HTS bearings in typical situations is discussed. The article concludes with a brief survey of various proposed applications for HTS bearings.

  15. Teddy Bear Stories

    DEFF Research Database (Denmark)

    van Leeuwen, Theo; Caldas-Coulthardt, Carmen

    2014-01-01

    This paper presents a semiotic analysis of a key cultural artefact, the teddy bear. After introducing the iconography of the teddy bear, it analyses different kinds of stories to show how teddy bears are endowed with meaning in everyday life: stories from children's books, reminiscenses by adults...... about their childhood teddy bears, and children's accounts of what they do with teddy bears, both written for school and told 'out of school', The chapter sees teddy bears as artefacts that provide a cultural channeling for the child's need of a transitional object and argues that the meanings of teddy...... bears have traditionally centred on interpersonal relations within the nuclear family, but have recently been institutionalized and commercialized....

  16. Ivermectin alone or in combination with benzyl benzoate in the treatment of human immunodeficiency virus-associated scabies.

    Science.gov (United States)

    Alberici, F; Pagani, L; Ratti, G; Viale, P

    2000-05-01

    In order to establish a safe and reliable treatment for human immunodeficiency virus (HIV)-associated scabies, we have treated 60 episodes of scabies in this setting, occurring in 39 patients, with one of the following regimens: (i) topical treatment with benzyl benzoate solution; (ii) single-dose oral treatment with ivermectin alone; and (iii) combination therapy with benzyl benzoate solution and oral ivermectin, employing the same regimens as single-agent therapy. Patients were stratified according to the severity score of the disease and the outcome (eradication, relapse, failure). We found that both benzyl benzoate and ivermectin alone were quite effective in mild to moderate scabies, but they were both associated with an unacceptable rate of relapse and failure in severe or crusted scabies. In contrast, combined treatment produced an optimal rate of success, without significant treatment-related side-effects. Therefore, we consider that combination treatment with benzyl benzoate solution and oral ivermectin is preferable to single-agent therapy in crusted scabies occurring in HIV/acquired immune deficiency syndrome patients.

  17. Optimization of Pseudomonas putida KT2440 as host for the production of cis, cis-muconate from benzoate

    NARCIS (Netherlands)

    Duuren, van J.B.J.H.

    2011-01-01

    Optimization of Pseudomonas putida KT2440 as host for the production of cis, cis-muconate from benzoate P. putida KT2440 was used as biocatalyst given its versatile and energetically robust metabolism. Therefore, a mutant was generated and a process developed based on which a life cycle assessment

  18. Food preservatives sodium benzoate and propionic acid and colorant curcumin suppress Th1-type immune response in vitro.

    Science.gov (United States)

    Maier, Elisabeth; Kurz, Katharina; Jenny, Marcel; Schennach, Harald; Ueberall, Florian; Fuchs, Dietmar

    2010-07-01

    Food preservatives sodium benzoate and propionic acid and colorant curcumin are demonstrated to suppress in a dose-dependent manner Th1-type immune response in human peripheral blood mononuclear cells (PBMC) in vitro. Results show an anti-inflammatory property of compounds which however could shift the Th1-Th2-type immune balance towards Th2-type immunity.

  19. Effect of emamectin benzoate on mortality, proboscis extension, gustation and reproduction of the corn earworm, Helicoverpa zea.

    Science.gov (United States)

    López, Juan D; Latheef, M A; Hoffmann, W C

    2010-01-01

    Newly emerged corn earworm adults, Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) require a carbohydrate source from plant or other exudates and nectars for dispersal and reproduction. Adults actively seek and forage at feeding sites upon eclosion in the habitat of the larval host plant or during dispersal to, or colonization of, a suitable reproductive habitat. This nocturnal behavior of H. zea has potential for exploitation as a pest management strategy for suppression using an adult feeding approach. This approach entails the use of a feeding attractant and stimulant in combination with a toxicant that when ingested by the adult will either reduce fecundity/fertility at sub-lethal dosages or kill the adult. The intent of this study was to assess reproductive inhibition and toxicity of emamectin benzoate on H. zea when ingested by the adults when mixed in ppm active ingredient (wt:vol) with 2.5 M sucrose as a feeding stimulant. Because the mixture has to be ingested to function, the effect of emamectin benzoate was also evaluated at sub-lethal and lethal concentrations on proboscis extension and gustatory response of H. zea in the laboratory. Feral males captured in sex pheromone-baited traps in the field were used for toxicity evaluations because they were readily available and were more representative of the field populations than laboratory-reared adults. Laboratory-reared female moths were used for reproduction effects because it is very difficult to collect newly emerged feral females from the field. Emamectin benzoate was highly toxic to feral H. zea males with LC(50) values (95% CL) being 0.718 (0.532-0.878), 0.525 (0.316-0.751), and 0.182 (0.06-0.294) ppm for 24, 48 and 72 h responses, respectively. Sub-lethal concentrations of emamectin benzoate did not significantly reduce proboscis extension response of feral males and gustatory response of female H. zea. Sublethal concentrations of emamectin benzoate significantly reduced percent larval hatch of

  20. Scientific Opinion on the safety and efficacy of sodium benzoate as a silage additive for pigs, poultry, bovines, ovines, goats, rabbits and horses

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Additives and Products or Substances used in Animal Feed

    2012-07-01

    Full Text Available

    Sodium benzoate is intended for use as a technological additive to improve the ensiling process at a proposed dose of 2 400 mg/kg fresh matter, the eventual use of the silage being for pigs, poultry, bovines, ovines, goats, rabbits and horses. The application of sodium benzoate in the preparation of silage at the proposed dose was safe for the target animals. The proposed maximum dose of sodium benzoate is estimated to result in a comparable consumer exposure as does its use as preservative in other feedingstuffs and to make a minimal contribution to consumer exposure. The FEEDAP Panel concluded that sodium benzoate when used as a silage additive is safe for the consumer. Sodium benzoate is not considered as a skin irritant but may be mildly irritant to the eyes. As no data on sensitisation appear to be available, the FEEDAP Panel considered it prudent to treat sodium benzoate as a potential sensitiser. In the absence of information on particle size and dusting potential, a risk from inhalation cannot be excluded. The FEEDAP Panel concluded that there are no safety concerns for the environment resulting from the use of sodium benzoate as a silage additive. Based on a series of laboratory studies, sodium benzoate at the recommended dose was shown to have the potential to improve the production of silage by reducing pH and increasing the preservation of dry matter. This was demonstrated in a range of easy, moderately difficult and difficult to ensile forage materials. Sodium benzoate at concentrations between 250 and 2 500 mg/kg forage also has the potential to increase the aerobic stability of ensiled materials at a wide range of dry matter content.

  1. Exploiting members of the BAHD acyltransferase family to synthesize multiple hydroxycinnamate and benzoate conjugates in yeast

    DEFF Research Database (Denmark)

    Eudes, Aymerick; Mouille, Maxence; Robinson, David S.

    2016-01-01

    hydroxycinnamate esters; tropane alkaloids; and benzoate/caffeate alcohol esters. In some instances, the additional expression of Flavobacterium johnsoniae tyrosine ammonia-lyase (FjTAL) allowed the synthesis of p-coumarate conjugates and eliminated the need to supplement the culture media with 4-hydroxycinnamate......Background: BAHD acyltransferases, named after the first four biochemically characterized enzymes of the group, are plant-specific enzymes that catalyze the transfer of coenzyme A-activated donors onto various acceptor molecules. They are responsible for the synthesis in plants of a myriad...... syntheses that consume petroleum-based precursors. However, identification of appropriate enzymes and validation of their functional expression in heterologous hosts is a prerequisite for the design and implementation of metabolic pathways in microbes for the synthesis of such target chemicals...

  2. Electro-optic and dynamic studies of biphenyl benzoate ferroelectric liquid crystals

    Energy Technology Data Exchange (ETDEWEB)

    Hemine, J., E-mail: hemine1@yahoo.f [Laboratoire de Physique de la Matiere Condensee, Universite Hassan II, Mohammedia-Casablanca, BP 146, F.S.T. Mohammedia (Morocco); Daoudi, A. [Universite Lille Nord de France, F-59000 Lille (France); ULCO, LDSMM, F-59140 Dunkerque (France); CNRS UMR8024, F-59140 Dunkerque (France); Legrand, C. [Universite Lille Nord de France, F-59000 Lille (France); ULCO, LEMCEL, F-62228 Calais (France); El kaaouachi, A.; Nafidi, A. [Laboratoire de Physique de la Matiere Condensee, Faculte des Sciences Ibnou Zohr, BP 28/S 80000 Agadir (Morocco); Ismaili, M.; Isaert, N. [Universite Lille Nord de France, F-59000 Lille (France); USTL, LDSMM, F-59655 Villeneuve d' Ascq (France); CNRS UMR8024, F-59655 Villeneuve d' Ascq (France); Nguyen, H.T. [Centre de Recherche Paul Pascal, Universite de Bordeaux 1, 33600 Pessac (France)

    2010-05-01

    We present electro-optic and dynamic properties on three homologous of biphenyl benzoate series of ferroelectric liquid crystals (FLCs) exhibiting the chiral smectic C phase (SmC*). The three compounds present high spontaneous polarization and show the SmC*-SmA*-N* phase sequence. Dielectric spectroscopy was used to provide the dynamics and dipolar ordering of the ferroelectric phase. The Goldstone relaxation mode was studied for sample cells on planar geometry without a DC bias voltage. The rotational viscosity corresponding to molecular motions in the SmC* phase was determined from dielectric measurements. The Arrhenius-type behavior of the rotational viscosity was found and the corresponding activation energies were evaluated.

  3. Spectroscopic studies on the interaction of sodium benzoate, a food preservative, with calf thymus DNA.

    Science.gov (United States)

    Zhang, Guowen; Ma, Yadi

    2013-11-01

    The interaction between sodium benzoate (SB) and calf thymus DNA in simulated physiological buffer (pH 7.4) using acridine orange (AO) dye as a fluorescence probe, was investigated by UV-Vis absorption, fluorescence and circular dichroism (CD) spectroscopy along with DNA melting studies and viscosity measurements. An expanded UV-Vis spectral data matrix was resolved by multivariate curve resolution-alternating least squares (MCR-ALS) approach. The equilibrium concentration profiles and the pure spectra for SB, DNA and DNA-SB complex from the high overlapping composite response were simultaneously obtained. The results indicated that SB could bind to DNA, and hydrophobic interactions and hydrogen bonds played a vital role in the binding process. Moreover, SB was able to quench the fluorescence of DNA-AO complex through a static procedure. The quenching observed was indicative of an intercalative mode of interaction between SB and DNA, which was supported by melting studies, viscosity measurements and CD analysis.

  4. σ- versus π-Activation of Alkynyl Benzoates Using B(C6F53

    Directory of Open Access Journals (Sweden)

    Alexander Bähr

    2015-03-01

    Full Text Available We have prepared a range of alkynyl benzoates in high yields and have investigated their reactivities with the strong Lewis acid B(C6F53. In such molecules both σ-activation of the carbonyl and π-activation of the alkyne are possible. In contrast to the reactivity of propargyl esters with B(C6F53 which proceed via 1,2-addition of the ester and B(C6F53 across the alkyne, the inclusion of an additional CH2 spacer switches off the intramolecular cyclization and selective σ-activation of the carbonyl group is observed through adduct formation. This change in reactivity appears due to the instability of the species which would be formed through B(C6F53 activation of the alkyne.

  5. EcoBears

    DEFF Research Database (Denmark)

    Nielsen, Nick; Pedersen, Sandra Bleuenn; Sørensen, Jens Ager

    2015-01-01

    In this paper, we introduce the EcoBears concept that aims to augment household appliances with functional and aesthetic features to promote their "use'' and "longevity of use'' to prevent their disposal. The EcoBears also aim to support the communication of environmental issues in the home setting....... We present our initial design and implementation of the EcoBears that consist of two bear modules (a mother and her cub). We also present our preliminary concept validations and lessons learned to be considered for future directions....

  6. Damper bearing rotordynamics

    Science.gov (United States)

    Elrod, David A.

    1990-01-01

    High side loads reduce the life of the Space Shuttle Main Engine (SSME) High Pressure Oxygen Turbopump (HPOTP) bearings. High stiffness damper seals were recommended to reduce the loads on the pump and turbine end bearings in the HPOTP. The seals designed for use on the pump end are expected to adequately reduce the bearing loads; the predicted performance of the planned turbine end seal is marginal. An alternative to the suggested turbine end seal design is a damper bearing with radial holes from the pressurized center of the turbopump rotor, feeding a smooth land region between two rough-stator/smooth-rotor annular seals. An analysis was prepared to predict the leakage and rotor dynamic coefficients (stiffness, damping, and added mass) of the damper bearing. Governing equations of the seal analysis modified to model the damper bearing; differences between the upstream conditions of the damper bearing and a typical annular seal; prediction of the damper bearing analysis; and assumptions of the analysis which require further investigation are described.

  7. Simultaneous Determination of Sodium Benzoate Potassium Sor­bate and Natamycin Content in Iranian Yoghurt Drink (Doogh and the Associated Risk of Their Intake through Doogh Consumption

    Directory of Open Access Journals (Sweden)

    Zahra Esfandiari

    2013-08-01

    Full Text Available Background: Regarding the public health concerns over the use of food preservatives in yoghurt drink “Doogh", the aim of this study was the determination of sodium benzoate, potassium sorbate and natamycin in Doogh. Based on Iranian national standard, none of these preservatives are permitted to be used in Doogh.Methods: A total of 39 Doogh samples were analyzed through RP- HPLC in order to quantify sodium benzoate, potassium sorbate and natamaycin simultaneously. Exposure to each preservative is estimated by mean and maximum concentrations as the residue levels. The per capita Doogh consumption was calculated by the published data from official reports for Doogh annual production in Iran.Results: All samples were shown to contain sodium benzoate while natamaycin was detected in 10.25% of the samples and potassium sorbate was not detected in any of them. Sodium benzoate concentration extremely varied among the investigated samples ranged from 0.94 to 9.77 mg/l. Due to the result of the exposure estimation, no serious public health concern would exist regarding the mentioned preservatives.Conclusions: The detection of sodium benzoate in all Doogh samples could indicate the natural production of benzoic acid in yoghurt. Sodium benzoate may be formed through the interaction of the added food grade salt to the Doogh formula which contains benzoic acid. The results of exposure estimation show the lack of health risk within the usage of preservatives in spite of the national regulatory agencies does not permit the preservative use.

  8. Ultra-precision bearings

    CERN Document Server

    Wardle, F

    2015-01-01

    Ultra-precision bearings can achieve extreme accuracy of rotation, making them ideal for use in numerous applications across a variety of fields, including hard disk drives, roundness measuring machines and optical scanners. Ultraprecision Bearings provides a detailed review of the different types of bearing and their properties, as well as an analysis of the factors that influence motion error, stiffness and damping. Following an introduction to basic principles of motion error, each chapter of the book is then devoted to the basic principles and properties of a specific type of bearin

  9. Changes induced by UV radiation in the presence of sodium benzoate in films formulated with polyvinyl alcohol and carboxymethyl cellulose

    Energy Technology Data Exchange (ETDEWEB)

    Villarruel, S. [Faculty of Exact Sciences, UNLP (Argentina); Giannuzzi, L.; Rivero, S. [Center for Research and Development in Food Cryotechnology (CCT-CONICET La Plata), 47 and 116 (Argentina); Pinotti, A., E-mail: acaimpronta@hotmail.com [Center for Research and Development in Food Cryotechnology (CCT-CONICET La Plata), 47 and 116 (Argentina); Faculty of Engineering, UNLP, La Plata 1900 (Argentina)

    2015-11-01

    This work was focused on: i) developing single and blend films based on carboxymethyl cellulose (CMC) and polyvinyl alcohol (PVOH) studying their properties, ii) analyzing the interactions between CMC and PVOH and their modifications UV-induced in the presence of sodium benzoate (SB), and iii) evaluating the antimicrobial capacity of blend films containing SB with and without UV treatment. Once the blend films with SB were exposed to UV radiation, they exhibited lower moisture content as well as a greater elongation at break and rougher surfaces compared to those without treatment. Considering oxygen barrier properties, the low values obtained would allow their application as packaging with selective oxygen permeability. Moreover, the characteristics of the amorphous phase of the matrix prevailed with a rearrangement of the structure of the polymer chain, causing a decrease of the crystallinity degree. These results were supported by X-rays and DSC analysis. FT-IR spectra reflected some degree of polymer–polymer interaction at a molecular level in the amorphous regions. The incorporation of sodium benzoate combined with UV treatment in blend films was positive from the microbial point of view because of the growth inhibition of a wide spectrum of microorganisms. From a physicochemical perspective, the UV treatment of films also changed their morphology rendering them more insoluble in water, turning the functionalized blend films into a potential material to be applied as food packaging. - Highlights: • CMC:PVOH blend films were developed with the addition of sodium benzoate (SB). • Exposition to UV radiation was carried out with sodium benzoate as photoinitiator. • Blend films were exposed to UV radiation to modify their surface morphology. • Low O{sub 2} permeability of UV treated blends allow them to be used as selective packaging. • Efficacy of SB as an antimicrobial agent was examined with and without UV radiation.

  10. Efficacy of vinegar, sorbitol and sodium benzoate in mitigation of Salmonella contamination in betel leaf

    Directory of Open Access Journals (Sweden)

    Al Asmaul Husna

    2015-06-01

    Full Text Available The present study was undertaken to mitigate Salmonella from betel leaf in Mymensingh. A total of 35 betel leaf samples were collected from 2 baroujes and 5 local markets in Mymensingh. The samples were sub-divided into two groups: (i phosphate buffer solution (PBS washed, and (ii grinded sample. There was control and treated (with 1.5% vinegar, sorbitol, and sodium benzoate sub-groups in both groups. Mitigation of Salmonella was determined by comparing Total Viable Count (TVC and Total Salmonella Count (TSAC of control with treated groups. No bacterial growth was observed in the betel leaf samples collected directly from barouj level. At market level, when grinded, there was no growth of bacteria in Plate Count Agar (PCA and Salmonella- Shigella (SS or Xylose Lysine De-oxy-chocolate (XLD in both treated and untreated groups. But when the PBS washed samples were used, the TVC (mean log CFU±SD/mL of betel leaf ranged from 5.16±0.82 to 5.96±1.11, whereas the TSAC value ranged from 4.87±0.58 to 5.56±1.00 for untreated group. In vinegar, there was no growth, but when treated with sorbitol, the TVC (mean log CFU±SD/mL value reduced to 5.00±0.54 to 5.66±1.09, and TSAC (mean log CFU±SD/mL value reduced to 4.28±0.71 to 4.78±0.64. When treated with sodium benzoate, the TVC (mean log CFU±SD/mL value reduced to 5.06±0.53 to 5.75±1.02, and TSAC (mean log CFU±SD/mL value reduced to 4.34±0.79 to 4.92±0.64. Data of this study indicates that all the three chemicals were effective in terms of reducing bacterial load but vinegar (1.5% was found to be the most effective against Salmonella as well as some other bacteria when treated for 10 min.

  11. Dietary exposure of children and teenagers to benzoates, sulphites, butylhydroxyanisol (BHA) and butylhydroxytoluen (BHT) in Beirut (Lebanon).

    Science.gov (United States)

    Soubra, L; Sarkis, D; Hilan, C; Verger, Ph

    2007-02-01

    The acceptable daily intake (ADI) for a considered chemical is by definition the amount of that substance which can be ingested every day during the life time without appreciable health risk. The theoretical risk of exceeding the ADI for benzoates, sulphites, butylhydroxyanisol (BHA) and butylhydroxytoluen (BHT) has often been examined on the basis of worst case scenario. The aim of this paper is to assess the actual intake of the food additives listed above for a group of the Lebanese population (students aged between 9 and 18 years old) likely to be highly exposed to food additives through the consumption of processed foods. Dietary exposure was obtained by combining food consumption data with food additives levels determined by chemical analysis. Food products available in Lebanon and containing added benzoates, sulphites, BHA and BHT were identified. Overall 420 samples of foods and beverages were analysed. The determination of food additives residue levels was carried out according to the official methods adopted in "Lebanese Institute for agronomic research" (IRAL) on food as consumed. The acceptable daily intake (ADI) could be exceeded for sulphites and BHT by a fraction of the population, in particular within children of 9-13 years old. Among all food additive-containing foods, the highest contributors were: soft drinks to benzoates intake, nuts and canned juices to sulphites intake, bread and biscuits to BHA intake and chewing gum to BHT intake.

  12. Effects of heat shocks on microbial community structure and microbial activity of a methanogenic enrichment degrading benzoate.

    Science.gov (United States)

    Mei, R; Narihiro, T; Nobu, M K; Liu, W-T

    2016-11-01

    In anaerobic digesters, temperature fluctuation could lead to process instability and failure. It is still not well understood how digester microbiota as a whole respond to heat shock, and what specific organisms are vulnerable to perturbation or responsible for process recovery after perturbation. To address these questions, a mesophilic benzoate-degrading methanogenic culture enriched from digester was subjected to different levels of heat shock. Three types of methane production profiles after perturbation were observed in comparison to the control: uninhibited, inhibited with later recovery, and inhibited without recovery. These responses were correlated with the microbial community compositions based on the analyses of 16S rRNA and 16S rRNA gene. Specifically, the primary benzoate-degrading syntroph was highly affected by heat shock, and its abundance and activity were both crucial to the restoration of benzoate degradation after heat shock. In contrast, methanogens were stable regardless whether methane production was inhibited. Populations related to 'Candidatus Cloacimonetes' and Firmicutes showed stimulated growth. These observations indicated distinct physiological traits and ecological niches associated with individual microbial groups. The results obtained after exposure to heat shock can be critical to more comprehensive characterization of digester ecology under perturbations.

  13. Spectroscopic, optical, thermal, antimicrobial and density functional theory studies of 4-aminopyridinium 4-hydroxy benzoate hydrate crystal

    Science.gov (United States)

    Karthiga Devi, P.; Venkatachalam, K.; Poonkothai, M.

    2016-09-01

    The organic crystal 4-aminopyridinium 4-hydroxy benzoate hydrate was grown using slow evaporation method. Various characterization techniques such as single crystal X-ray diffraction, powder X-ray diffraction, FTIR, UV-visible-NIR spectroscopy and thermal analysis (TG-DSC) were employed to assay the structure and properties of the grown crystal. The antimicrobial evaluation of 4-aminopyridinium 4-hydroxy benzoate hydrate crystal was also performed against some bacteria and fungi. The minimum inhibitory concentration (MIC) values of 4-aminopyridinium 4-hydroxy benzoate hydrate were determined for bacterial and fungal strains. The assessment of optimized structure of the molecule and vibrational frequencies were done using DFT/B3LYP method with 6-31 G (d, p) basis set. The stability of the molecule, hyperconjugative interactions, delocalization of charges and intermolecular hydrogen bond were studied by applying natural bond orbital (NBO) analysis. TD-DFT method employing polarizable continuum model (PCM) was used to examine the electronic absorption spectrum. Evaluation of molecular electrostatic potential (MEP), Mulliken population charges and nonlinear optical (NLO) properties were also carried out. In addition, from the optimized geometry, frontier molecular orbitals analysis was executed.

  14. Gear bearing drive

    Science.gov (United States)

    Weinberg, Brian (Inventor); Mavroidis, Constantinos (Inventor); Vranish, John M. (Inventor)

    2011-01-01

    A gear bearing drive provides a compact mechanism that operates as an actuator providing torque and as a joint providing support. The drive includes a gear arrangement integrating an external rotor DC motor within a sun gear. Locking surfaces maintain the components of the drive in alignment and provide support for axial loads and moments. The gear bearing drive has a variety of applications, including as a joint in robotic arms and prosthetic limbs.

  15. Rolling bearing analysis

    CERN Document Server

    Harris, Tedric A

    2001-01-01

    One of the most well-known experts in the field brings cutting-edge research to practitioners in the new edition of this important reference. Covers the improved mathematical calculations for rolling bearing endurance developed by the American Society of Mechanical Engineers and the Society of Lubrication and Tribology Engineers. Updated with new material on Condition-Based Maintenance, new testing methods, and new bearing materials.

  16. My Little Teddy Bear

    Institute of Scientific and Technical Information of China (English)

    钱佳楠

    2005-01-01

    @@ As Valentine's Day came closer,every shop was full of colourful gifts such as cookies in the shape of heart, chocolates,Teddy Bears and so on.When I step into a shop on February 14th,I felt most lonely as I was alone.With mv eves fixed on a lovely Teddy Bear, I wished that someone could send me this stuffed toy.

  17. Identification, isolation and characterization of process-related impurities in Rizatriptan benzoate.

    Science.gov (United States)

    Raj, T Joseph Sunder; Bharathi, Ch; Kumar, M Saravana; Prabahar, Joseph; Kumar, P Naveen; Sharma, Hemant Kumar; Parikh, Kalpesh

    2009-01-15

    Three process-related impurities were observed in routine monitoring of the samples by HPLC. These impurities were identified by LC-MS. One of the impurities, Imp-3 [rizatriptan-2,5-dimer] was reported in literature. Other two impurities were isolated by preparative HPLC and characterized by NMR, Mass and IR. Pure impurities obtained by isolation were co-injected with Rizatriptan benzoate sample to confirm the retention times in HPLC. Structure elucidation of these impurities by spectral data has been discussed in detail. These impurities were identified as 4-(5-((1H-1,2,4-triazol-1-yl)methyl)-3-(2-(dimethylamino)ethyl)-1H-indol-1-yl)-4-(5-((1H-1,2,4-triazol-1-yl)methyl)-3-(2-(dimethylamino)ethyl)-1H-indol-2-yl)-N,N-dimethylbutan-1-amine [rizatriptan-1,2-dimer] and [4,4-bis-(5-((1H-1,2,4-triazol-1-yl)methyl)-3-(2-(dimethylamino)-ethyl)-1H-indol-2-yl)-N,N-dimethylbutan-1-amine [rizatriptan-2,2-dimer].

  18. High secondary [alpha]-deuterium kinetic isotope effect in the acetolysis and formolysis of dideuterioferrocenylmethyl benzoate

    Energy Technology Data Exchange (ETDEWEB)

    Asperger, S. (Research Center of the Croatian Academy of Sciences and Arts, Zagreb (Croatia)); Kukric, Z.; Sutic, D. (Sarajevo Univ. (Yugoslavia). Faculty of Natural Sciences and Mathematics); Saunders, W.H. Jr. (Rochester Univ., NY (United States). Dept. of Chemistry)

    1992-02-01

    Acetolysis and formolysis of dideuterioferrocenylmethyl benzoate exhibit large secondary deuterium kinetic isotope effects and an abnormal temperature dependence. In the presence of LiClO[sub 4], which prevents the reversion from solvent-separated to contact ion-pairs, K[sub H]/K[sub D] at 25 [sup o]C amount to 1.53 [+-] 0.02 (acetolysis) and 1.48 [+-] 0.03 (formolysis). In the presence of LiClO[sub 4] the ratios of Arrhenius pre-exponential factors, A[sub H]/A[sub D], are significantly less than unity and amount to 0.49 [+-] 0.01 (acetolysis) and 0.38 [+-] 0.04 (formolysis). In the absence of LiClO[sub 4] the A[sub H]/A[sub D] ratios are much smaller (0.02 both in acetolysis and formolysis). We suggest that these surprisingly low values result from a change in rate-determining step over the temperature range, from formation of the solvent-separated ion-pair at low temperatures to reaction of the dissociated carbocation with solvent at the highest temperatures. Whether tunnelling plays any role in these solvolyses is discussed. (Author).

  19. 17beta-estradiol benzoate decreases the AHP amplitude in CA1 pyramidal neurons.

    Science.gov (United States)

    Kumar, Ashok; Foster, Thomas C

    2002-08-01

    Disruption of Ca(2+) homeostasis is hypothesized to mediate several electrophysiological markers of brain aging. Recent evidence indicates that estradiol can rapidly alter Ca(2+)-dependent processes in neurons through nongenomic mechanisms. In the current study, electrophysiological effects of 17beta-estradiol benzoate (EB) on the Ca(2+)-activated afterhyperpolarization (AHP) were investigated using intracellular sharp electrode recording in hippocampal slices from ovariectomized Fischer 344 female rats. The AHP amplitude was enhanced in aged (22-24 mo) compared with young (5-8 mo) rats and direct application of EB (100 pM) reduced the AHP in aged rats. The age-related difference was due, in part, to the increased AHP amplitude of aged animals, since an EB-mediated decrease in the AHP could be observed in young rats when the extracellular Ca(2+) was elevated to increase the AHP amplitude. In aged rats, bath application of EB occluded the ability of the L-channel blocker, nifedipine (10 microM), to attenuate the AHP. The results support a role for EB in modifying hippocampal Ca(2+)-dependent processes in a manner diametrically opposite that observed during aging, possibly through L-channel inhibition.

  20. Spectral Properties and Solubilization Location of 2'-Ethylhexyl 4-(N,N-Dimethylamino)benzoate in Micelles

    Institute of Scientific and Technical Information of China (English)

    Ning Ding; Xin-zhen Du; Chun Wang; Xiao-quan Lu

    2008-01-01

    Dual fluorescence and UV absorption of 2'-ethylhexyl 4-(N,N-dimethylamino)benzoate (EHDMAB) were investigated in cationic,non-ionic and anionic miceUes.When EHDMAB was solubilized in different micellss, the UV absorption of EHDMAB was enhanced.Twisted intramolecular charge transfer (TICT) emission with longer wavelength was observed in ionic micelles,whereas TICT emission with shorter wavelength was obtained in non-ionic micelles.In particular,dual fluorescence of EHDMAB was significantly quenched by the positively charged pyridinium ions arranged in the Stern layer of cationic micelles.UV radiation absorbed mainly decays via TICT emission and radiationless deactivation.The dimethylamino group of EHDMAB experiences different polar environments in ionic and non-ionic micelles according to the polarity dependence of TICT emission of EHDMAB in organic solvents.In terms of the molecular structures and sizes of EHDMAB and surfactants,each individual EHDMAB molecule should be buried in micelles with its dimethylamino group toward the polar head groups of different micelles and with its 2'-ethylhexyl chain toward the hydrophobic micellar core.Dynamic fluorescence quenching measurements of EHDMAB provide further support for the location of EHDMAB in different micelles.

  1. Simultaneous determination of a quaternary mixture of oxomemazine, sodium benzoate, guaifenesin and paracetamol by chromatographic methods

    Directory of Open Access Journals (Sweden)

    Nehal F. Farid

    2014-12-01

    Full Text Available The aim of the present work was to develop simple, accurate, sensitive and selective methods for the simultaneous determination of oxomemazine (Ox, sodium benzoate (SB, guaifenesin (Gu, andparacetamol (Par. Two methods were described and validated for the simultaneous determination of the four drugs in syrup and suppositories. The first method was a reversed phase HPLC and UVdetection at 220 nm. The assay was performed using C 18 column and an isocratic elution using acetonitrile – methanol – 35 mM KH2PO4 (20: 5: 75; by volume, pH was adjusted to 2.9 ± 0.1 as the mobile phase. The flow rate was 1.5 mL/min and separation was achieved in less than 15 min. The second method was a TLC- spectrodensitometric method, used to separate, identify and quantify the four drugs when present in combination. The drugs were applied on silica gel plates and development was made using methylene chloride- methanol- acetic acid- 33% ammonia (89: 8.4: 2: 0.6, by volume as a mobile phase. The bands of the four drugs were quantified by scanning spectrodensitometricaly at 270 nm. The suggested chromatographic methods were validated and applied successfully to the analysis of the syrup and suppositories.

  2. Molecular modeling of layered double hydroxide intercalated with benzoate, modeling and experiment.

    Science.gov (United States)

    Kovár, Petr; Pospísil, M; Nocchetti, M; Capková, P; Melánová, Klára

    2007-08-01

    The structure of Zn4Al2 Layered Double Hydroxide intercalated with benzencarboxylate (C6H5COO-) was solved using molecular modeling combined with experiment (X-ray powder diffraction, IR spectroscopy, TG measurements). Molecular modeling revealed the arrangement of guest molecules, layer stacking, water content and water location in the interlayer space of the host structure. Molecular modeling using empirical force field was carried out in Cerius(2) modeling environment. Results of modeling were confronted with experiment that means comparing the calculated and measured diffraction pattern and comparing the calculated water content with the thermogravimetric value. Good agreement has been achieved between calculated and measured basal spacing: d(calc) = 15.3 A and d(exp) = 15.5 A. The number of water molecules per formula unit (6H2O per Zn4Al2(OH)12) obtained by modeling (i.e., corresponding to the energy minimum) agrees with the water content estimated by thermogravimetry. The long axis of guest molecules are almost perpendicular to the LDH layers, anchored to the host layers via COO- groups. Mutual orientation of benzoate ring planes in the interlayer space keeps the parquet arrangement. Water molecules are roughly arranged in planes adjacent to host layers together with COO- groups.

  3. Magnetic Bearing Consumes Low Power

    Science.gov (United States)

    Studer, P. A.

    1982-01-01

    Energy-efficient linear magnetic bearing maintains a precise small separation between its moving and stationary parts. Originally designed for cryogenic compressors on spacecraft, proposed magnetic bearing offers an alternative to roller or gas bearing in linear motion system. Linear noncontacting bearing operates in environments where lubricants cannot be used.

  4. Determination of Benzoate Level in Canned Pickles and Pickled Cucumbers in Food Producing Factories in Markazi Province and those that their Products were Sold in Arak City, Iran

    Directory of Open Access Journals (Sweden)

    Mostafa Delavar

    2012-11-01

    Full Text Available Background: Anecdotal information has suggested that sodium benzoate is used with more than permissible doses during production steps of food products especially pickles and pickled cucumbers in food producing factories in Markazi province and other food producing factories . The present study was done to evaluate factual concentration of sodium benzoate in these products. Methods: In this study, 8 samples from canned pickled cucumbers and 10 samples from canned pickles were randomly gathered from food production factories in Markazi province between March and September 2010. Also, 25 samples from canned pickled cucumbers and 15 samples from canned pickles and 7 samples of bulk cargo pickled cucumbers were collected from the other provinces in Arak city. Sodium benzoate level was determined in the samples using UV-VIS spectrophotometry method. The determined values were analyzed by N-par test using SPSS software version 16.0. Results: Sodium benzoate level was near zero in the samples of canned pickles and pickled cucumbers from producing factories. This was 200-400 PPM in 7 samples from bulk cargo pickled cucumbers which was higher than permissible dose. There was not a statistically significant difference between mean benzoate level of canned pickles and pickled cucumbers produced in Markazi providence factories and other food factories. Benzoate level was significantly higher than permissible dose in bulk cargo pickled cucumbers. Conclusion: Food products from production factories do not have higher than permissible level of sodium benzoate; however, this is higher in bulk cargo pickled cucumbers. Hence, stricter control on bulk cargo pickled cucumber products is recommended.

  5. Tribology of alternative bearings.

    Science.gov (United States)

    Fisher, John; Jin, Zhongmin; Tipper, Joanne; Stone, Martin; Ingham, Eileen

    2006-12-01

    The tribological performance and biological activity of the wear debris produced has been compared for highly cross-linked polyethylene, ceramic-on-ceramic, metal-on-metal, and modified metal bearings in a series of in vitro studies from a single laboratory. The functional lifetime demand of young and active patients is 10-fold greater than the estimated functional lifetime of traditional polyethylene. There is considerable interest in using larger diameter heads in these high demand patients. Highly cross-linked polyethylene show a four-fold reduction in functional biological activity. Ceramic-on-ceramic bearings have the lowest wear rates and least reactive wear debris. The functional biological activity is 20-fold lower than with highly cross-linked polyethylene. Hence, ceramic-on-ceramic bearings address the tribological lifetime demand of highly active patients. Metal-on-metal bearings have substantially lower wear rates than highly cross-linked polyethylene and wear decreases with head diameter. Bedding in wear is also lower with reduced radial clearance. Differential hardness ceramic-on-metal bearings and the application of ceramic-like coatings reduce metal wear and ion levels.

  6. Radial Halbach Magnetic Bearings

    Science.gov (United States)

    Eichenberg, Dennis J.; Gallo, Christopher A.; Thompson, William K.

    2009-01-01

    Radial Halbach magnetic bearings have been investigated as part of an effort to develop increasingly reliable noncontact bearings for future high-speed rotary machines that may be used in such applications as aircraft, industrial, and land-vehicle power systems and in some medical and scientific instrumentation systems. Radial Halbach magnetic bearings are based on the same principle as that of axial Halbach magnetic bearings, differing in geometry as the names of these two types of bearings suggest. Both radial and axial Halbach magnetic bearings are passive in the sense that unlike most other magnetic bearings that have been developed in recent years, they effect stable magnetic levitation without need for complex active control. Axial Halbach magnetic bearings were described in Axial Halbach Magnetic Bearings (LEW-18066-1), NASA Tech Briefs, Vol. 32, No. 7 (July 2008), page 85. In the remainder of this article, the description of the principle of operation from the cited prior article is recapitulated and updated to incorporate the present radial geometry. In simplest terms, the basic principle of levitation in an axial or radial Halbach magnetic bearing is that of the repulsive electromagnetic force between (1) a moving permanent magnet and (2) an electric current induced in a stationary electrical conductor by the motion of the magnetic field. An axial or radial Halbach bearing includes multiple permanent magnets arranged in a Halbach array ("Halbach array" is defined below) in a rotor and multiple conductors in the form of wire coils in a stator, all arranged so the rotary motion produces an axial or radial repulsion that is sufficient to levitate the rotor. A basic Halbach array (see Figure 1) consists of a row of permanent magnets, each oriented so that its magnetic field is at a right angle to that of the adjacent magnet, and the right-angle turns are sequenced so as to maximize the magnitude of the magnetic flux density on one side of the row while

  7. Partial tooth gear bearings

    Science.gov (United States)

    Vranish, John M. (Inventor)

    2010-01-01

    A partial gear bearing including an upper half, comprising peak partial teeth, and a lower, or bottom, half, comprising valley partial teeth. The upper half also has an integrated roller section between each of the peak partial teeth with a radius equal to the gear pitch radius of the radially outwardly extending peak partial teeth. Conversely, the lower half has an integrated roller section between each of the valley half teeth with a radius also equal to the gear pitch radius of the peak partial teeth. The valley partial teeth extend radially inwardly from its roller section. The peak and valley partial teeth are exactly out of phase with each other, as are the roller sections of the upper and lower halves. Essentially, the end roller bearing of the typical gear bearing has been integrated into the normal gear tooth pattern.

  8. The Little Bear

    Institute of Scientific and Technical Information of China (English)

    林战峰; 乐伟国

    2007-01-01

    @@ 一、故事内容 A little bear has a magic stick.It can make his wishes come true. One day,the little bear is walking in the forest.He sees a bird.It is flying in the sky.It has two beautiful wings."I want two beautiful wings.I wish I can fly like a bird,"he says to the magic stick.Two beautiful wings come out from his back and he can fly like a bird now.He is very happy.

  9. Modular gear bearings

    Science.gov (United States)

    Vranish, John M. (Inventor)

    2009-01-01

    A gearing system using modular gear bearing components. Each component is composed of a core, one or more modules attached to the core and two or more fastening modules rigidly attaching the modules to the core. The modules, which are attached to the core, may consist of gears, rollers or gear bearing components. The core orientation affects the orientation of the modules attached to the core. This is achieved via the keying arrangement of the core and the component modules that attach to the core. Such an arrangement will also facilitate the phase tuning of gear modules with respect to the core and other gear modules attached to the core.

  10. Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers.

    Science.gov (United States)

    Deloose, Eveline; Janssen, Pieter; Corsetti, Maura; Biesiekierski, Jessica; Masuy, Imke; Rotondo, Alessandra; Van Oudenhove, Lukas; Depoortere, Inge; Tack, Jan

    2017-03-01

    Background: Denatonium benzoate (DB) has been shown to influence ongoing ingestive behavior and gut peptide secretion.Objective: We studied how the intragastric administration of DB affects interdigestive motility, motilin and ghrelin plasma concentrations, hunger and satiety ratings, and food intake in healthy volunteers.Design: Lingual bitter taste sensitivity was tested with the use of 6 concentrations of DB in 65 subjects. A placebo or 1 μmol DB/kg was given intragastrically to assess its effect on fasting gastrointestinal motility and hunger ratings, motilin and ghrelin plasma concentrations, satiety, and caloric intake.Results: Women (n = 39) were more sensitive toward a lingual bitter stimulus (P = 0.005) than men (n = 26). In women (n = 10), intragastric DB switched the origin of phase III contractions from the stomach to the duodenum (P = 0.001) and decreased hunger ratings (P = 0.04). These effects were not observed in men (n = 10). In women (n = 12), motilin (P = 0.04) plasma concentrations decreased after intragastric DB administration, whereas total and octanoylated ghrelin were not affected. The intragastric administration of DB decreased hunger (P = 0.008) and increased satiety ratings (P = 0.01) after a meal (500 kcal) in 13 women without affecting gastric emptying in 6 women. Caloric intake tended to decrease after DB administration compared with the placebo (mean ± SEM: 720 ± 58 compared with 796 ± 45 kcal; P = 0.08) in 20 women.Conclusions: Intragastric DB administration decreases both antral motility and hunger ratings during the fasting state, possibly because of a decrease in motilin release. Moreover, DB decreases hunger and increases satiety ratings after a meal and shows potential for decreasing caloric intake. This trial was registered at clinicaltrials.gov as NCT02759926.

  11. Ameliorative effect of vitamin C against hepatotoxicity induced by emamectin benzoate in rats.

    Science.gov (United States)

    Khaldoun Oularbi, H; Richeval, C; Lebaili, N; Zerrouki-Daoudi, N; Baha, M; Djennas, N; Allorge, D

    2016-07-26

    In the present study, we aimed to assess the potential protective effect of ascorbic acid (AA) against emamectin benzoate (EMB)-induced hepatotoxicity. For this purpose, biochemical, histopathological and analytical investigations were performed. Male Wistar rats were distributed into three groups, that is, a control group, an EMB group given 10 mg EMB/kg body weight (BW) by gavage and an EMB + AA group given 10 mg EMB/kg BW and vitamin C intraperitoneally (200 mg/kg). The duration of the treatment was 28 days and the duration of the study was 42 days. There was a statistically significant increase of all hepatic biomarkers, that is, aspartate aminotransferase, alanine aminotransferase and gamma-glutamyltransferase activities, and glycemia, in EMB-treated group when compared with the control group. Light microscopic observations revealed variable signs of hepatotoxicity in the EMB group, which were represented by alteration of normal hepatic architecture, inflammatory cell infiltration, hepatocellular steatosis and foci of necrosis at 28 and 42 days post-treatment. However, co-treatment with vitamin C reduced EMB-related liver toxicity and diminished the abnormal biochemical and architectural damage. Emamectin B1a and B1b residues were detectable in all plasma samples of treated rats at 14, 21 and 28 days of treatment. The drug liver tissue concentration was significantly lower in EMB + AA group compared with EMB group at 28 and 42 days. In conclusion, the findings of the present study clearly indicate a significant protective action of vitamin C against EMB hepatotoxicity.

  12. Sensitive and selective spectrophotometric assay of rizatriptan benzoate in pharmaceuticals using three sulphonphthalein dyes

    Directory of Open Access Journals (Sweden)

    K.N. Prashanth

    2016-11-01

    Full Text Available Three simple, rapid, selective and sensitive spectrophotometric methods are described for the determination of rizatriptan benzoate (RTB in bulk drug and in tablets. The methods are based on the formation of intense yellow colored ion–pair complexes between RTB and sulphonphthalein acid dyes, namely, bromophenol blue (BPB, bromocresol purple (BCP, bromothymol blue (BTB in chloroform medium. The colored products are measured at 425 nm (RTB–BPB complex, RTB–BCP complex and 420 nm (RTB–BTB complex. The reactions were extremely rapid at room temperature and the absorbance values remained constant for 90 min (methods A and B and over 12 h (method C. Beer’s law was obeyed in the concentration ranges of 0.8–16.0, 1.0–20.0 and 1.2–24 μg ml−1 with molar absorptivity values of 1.76 × 104, 1.96 × 104 and 1.63 × 104 l mol−1 cm−1 for BPB, BCP and BTB methods, respectively. The limits of quantification (LOQ were 0.39, 0.34 and 0.27 μg ml−1 for BPB, BCP and BTB methods, respectively. Other method validation parameters, such as precision, accuracy, robustness, ruggedness and selectivity, were satisfactory. The composition of the ion–pair was found to be 1:1 by Job’s method. The proposed methods were successfully applied to the determination of RTB in commercial tablets. No interference was observed from common tablet adjuvants. Statistical comparison of the results with the reference method showed excellent agreement and indicated no significant difference in accuracy and precision.

  13. Exogenous Estradiol Benzoate Induces Spermatogenesis Disorder through Influencing Apoptosis and Oestrogen Receptor Signalling Pathway.

    Science.gov (United States)

    Lei, X; Cui, K; Liu, Q; Zhang, H; Li, Z; Huang, B; Shi, D

    2016-02-01

    As the exact role for exogenous oestrogen in spermatogenesis is not fully understood, the aim of this study was to investigate the effect of estradiol benzoate (EB) exposure to male mice on their spermatogenesis and fertility. Sixty male mice aged 4 weeks were randomly divided into three groups, including a control group and two treatment groups. The mice of the control group were injected with 250 μl paraffin oil only by every other day subcutaneous injection for 4 weeks. Meantime, the mice of the treatment groups were injected with EB at the concentration of 5 or 10 mg/kg, respectively. Results showed that EB slowed down the body weight gains and generated testicular atrophy with spermatogenesis disorder compared with that of the control mice, and consequently induced their infertility. Moreover, the number of TUNEL-positive cells in the testis of EB-treated mice was significantly increased with the EB concentration rise. In comparison with controls, the mRNA expression level of pro-apoptosis factors (Fas, TNF, Cytochrome C, Apaf1, Chop, Caspase-3, Caspase-8, Caspase-9 and Caspase-12) and key genes in oestrogen receptor (ER) signalling pathway (ER α, ER β, Erk1/2, Hsp90 and DAX-1) were upregulated in the testes of the treatment groups. Furthermore, Western blotting results proved the protein expression level of Fas, TNF, Cytochrome C, Chop, Caspase-3, cleaved Caspase-3, Caspase-9, Erk1/2 and Hsp90 were upregulated, and the phosphorylation level of Erk1/2 was also increased. These results indicate that EB may impair spermatogenesis through influencing the apoptosis and ER signalling pathway.

  14. Silver Bear for Screenplay

    Institute of Scientific and Technical Information of China (English)

    LIU YUNYUN

    2010-01-01

    @@ Chinese director Wang Quan'an won the Silver Bear Prize at the 60th Berlin International Film Festival that lasted during February 11 to 21 tor the best screenplay for his movie Apart Together.The film also opened the festival.

  15. Hybrid superconductor magnet bearings

    Science.gov (United States)

    Chu, Wei-Kan

    1995-01-01

    Hybrid superconductor magnet bearings (HSMB's) utilize high temperature superconductors (HTS's) together with permanent magnets to form a frictionless interface between relatively rotating parts. They are low mass, stable, and do not incur expenditure of energy during normal operation. There is no direct physical contact between rotor and stator, and hence there is no wear and tear. However, just as any other applications of HTS's, it requires a very cold temperature to function. Whereas this might be perceived as a disadvantage on earth, it is of no great concern in space or on the moon. To astronomers, the moon is an excellent site for an observatory, but the cold and dusty vacuum environment on the moon precludes the use of mechanical bearings on the telescope mounts. Furthermore, drive mechanisms with very fine steps, and hence bearings with extremely low friction are needed to track a star from the moon, because the moon rotates very slowly. All aspects considered, the HSMB is about the only candidate that fits in naturally. Here, we present a design for one such bearing, capable of supporting a telescope that weighs about 3 lbs on Earth.

  16. Magnetic bearings for cryogenic turbomachines

    Science.gov (United States)

    Iannello, Victor; Sixsmith, Herbert

    1991-01-01

    Magnetic bearings offer a number of advantages over gas bearings for the support of rotors in cryogenic turboexpanders and compressors. Their performance is relatively independent of the temperature or pressure of the process gas for a large range of conditions. Active magnetic bearing systems that use capacitive sensors have been developed for high speed compressors for use in cryogenic refrigerators. Here, the development of a magnetic bearing system for a miniature ultra high speed compressor is discussed. The magnetic bearing has demonstrated stability at rotational speeds exceeding 250,000 rpm. This paper describes the important features of the magnetic bearing and presents test results demonstrating its performance characteristics.

  17. Ivermectin versus benzyl benzoate applied once or twice to treat human scabies in Dakar, Senegal : a randomized controlled trial

    OpenAIRE

    Ly, Fatimata; Caumes, Eric; Ndaw, Cheick Ahmet Tidiane; Ndiaye, Bassirou; Mahé, Antoine

    2009-01-01

    Objective To compare the effectiveness of oral ivermectin (IV) and two different modalities of topical benzyl benzoate (BB) for treating scabies in a community setting. Methods The trial included patients aged 5-65 years with scabies who attended the dermatology department at the Institut d'Hygiene Sociale in Dakar, Senegal. The randomized, open trial considered three treatments: a single application of 12.5% BB over 24 hours (BB1. group), two applications of BB, each over 24 hours (BB2 group...

  18. Crystal structure of ethyl 4-[(E-(4-hydroxy-3-methoxybenzylideneamino]benzoate: a p-hydroxy Schiff base

    Directory of Open Access Journals (Sweden)

    Jing Ling

    2016-07-01

    Full Text Available The title p-hydroxy Schiff base, C17H17NO4, was synthesized via the condensation reaction of benzocaine with vanillin. The benzylidine and benzoate rings are inclined to one another by 24.58 (8°, and the conformation about the C=N bond is E. In the crystal, molecules are linked by O—H...N hydrogen bonds, forming zigzag chains propagating along [010]. Adjacent chains are linked by C—H...π and weak offset π–π interactions [intercentroid distance = 3.819 (1 Å], forming sheets parallel to (10-2.

  19. PLASMID-ENCODED PHTHALATE CATABOLIC PATHWAY IN ARTHROBACTER KEYSERI 12B: BIOTRANSFORMATIONS OF 2-SUBSTITUTED BENZOATES AND THEIR USE IN CLONING AND CHARACTERIZATION OF PHTHALATE CATABOLISM GENES AND GENE PRODUCTS

    Science.gov (United States)

    Several 2-substituted benzoates (including 2-trifluoromethyl-, 2-chloro-, 2-bromo-, 2-iodo-, 2-nitro-, 2-methoxy-, and 2-acetyl-benzoates) were converted by phthalate-grown Arthrobacter keyseri 12B to the corresponding 2-substituted 3,4-dihydroxybenzoates (protocatechuates)...

  20. Magnetic bearings grow more attractive

    Science.gov (United States)

    1993-10-01

    Advances in materials and electronics have enabled designers to devise simpler, smaller magnetic bearings. As a result, costs have dropped, widening the applications for these very-low-friction devices. Avcon (Advanced Controls Technology) has patented a permanent-magnet bias actively controlled bearing. Here high-energy rare earth permanent-magnet materials supply the basic bearing load levitation, while servo-driven electromagnets generate stabilization and centering forces for motion contol. Previous heavy-duty magnetic bearings used electromagnets entirely for suspension and control, which led to large bearings and control systems with higher power requirements. Avcon has developed several types of permanent-magnet bias bearings. The simplest is the radial repulsion bearing. Avcon's homopolar permanent-magnet bias active bearing is the most versatile of the company's designs.

  1. Migration of Chemotactic Bacteria Transverse to Flow in Response to a Benzoate Source Plume Created in a Saturated Sand-Packed Microcosm

    Science.gov (United States)

    Ford, R.; Boser, B.

    2012-12-01

    Bioremediation processes depend on contact between microbial populations and the groundwater contaminants that they biodegrade. Chemotaxis, the ability of bacteria to sense a chemical gradient and swim preferentially toward locations of higher concentration, can enhance the transport of bacteria toward contaminant sources that may not be readily accessible by advection and dispersion alone. A two-dimensional rectangular-shaped microcosm packed with quartz sand was used to quantify the effect of chemotaxis on the migration of bacteria within a saturated model aquifer system. Artificial groundwater was pumped through the microcosm at a rate of approximately 1 m/day. A plume of sodium benzoate was created by continuous injection into an upper port of the microcosm to generate a chemical gradient in the vertical direction transverse to flow. Chemotactic bacteria, Pseudomonas putida F1, or the nonchemotactic mutant, P. putida F1 CheA, were injected with a conservative tracer in a port several centimeters below the benzoate position. As the injectates traversed the one-meter length of the microcosm, samples were collected from a dozen effluent ports to determine vertical concentration distributions for the bacteria, benzoate and tracer. A moment analysis was implemented to estimate the center of mass, variance, and skewness of the concentration profiles. The transverse dispersion coefficient and the transverse dispersivity for chemotactic and nonchemotactic bacteria were also evaluated. Experiments performed with a continuous injection of bacteria showed that the center of mass for chemotactic bacteria was closer to the benzoate source on average than the nonchemotactic control (relative to the conservative tracer). These results demonstrated that chemotaxis can increase bacterial transport toward contaminants, potentially enhancing the effectiveness of in situ bioremediation. Experiments with 2 cm and 3 cm spacing between bacteria and benzoate injection locations were

  2. Induction of parturition in swine with prostaglandin F(2)alpha, estradiol benzoate and oxytocin.

    Science.gov (United States)

    Gall, M A; Day, B N

    1987-03-01

    Pregnant sows and gilts were administered either 0, 2.5, 5, 10 or 20 mg prostaglandin F(2)alpha (PGF(2)alpha) intramuscularly on Day 112 or 113 of gestation at 0800 h in an effort to induce parturition. The average interval from PGF(2)alpha injection to farrowing was 55.1 +/- 5.7, 29.4 +/- 3.1, 32.1 +/- 4.6, 27.8 +/- 1.8 and 26.9 +/- 1.1 h for 0, 2.5, 5, 10 and 20 mg, respectively. All PGF(2)alpha treatments increased (P gestation length was significantly shorter in treated gilts; however, no detrimental effect on pig performance or pig survivability was observed. A second trial evaluated the effect of a 10-mg dose of PGF(2)alpha on the induction of parturition in sows in order to obtain a majority of sows farrowing within normal working hours (0700 to 1700 h). The interval from injection to farrowing was decreased (P < 0.05) by PGF(2)alpha treatment (66.2 +/- 5.3 vs 28.1 +/- 2.2 h). Fifty-seven percent (P < 0.05) of PGF(2)alpha-treated sows farrowed between 0700 and 1700 h as compared to 13.6% for control sows. A third trial was conducted to examine a sequential treatment of PGF(2)alpha and oxytocin to control the time of parturition more precisely. Sows receiving only 10 mg of PGF(2)alpha farrowed on an average 31.1 +/- 1.4 h after injection. The injection of 40 IU oxytocin 24 to 28 h after PGF(2)alpha decreased (P < 0.05) the interval from PGF(2)alpha to farrowing (28.1 +/- 0.9 h). The addition of oxytocin increased (P < 0.05) the number of sows farrowing within 3 h of injection (33 vs 86% for PGF(2)alpha and PGF(2)alpha + oxytocin treatments, respectively). A fourth trial was designed to determine if the addition of exogenous estradiol benzoate (EB) to a sequential treatment of PGF(2)alpha and oxytocin would improve the predictability and synchronization of the induced parturition. Sows were assigned to receive either saline, 10 mg PGF(2)alpha + 40 IU oxytocin or 10 mg PGF(2)alpha + 5 mg EB + 40 IU oxytocin. The addition of EB reduced (P < 0.01) the variance in

  3. The modulatory effect of estradiol benzoate on superoxide dismutase activity in the developing rat brain

    Directory of Open Access Journals (Sweden)

    S. Pejic

    2003-05-01

    Full Text Available The sensitivity of copper,zinc (CuZn- and manganese (Mn-superoxide dismutase (SOD to exogenous estradiol benzoate (EB was investigated in Wistar rats during postnatal brain development. Enzyme activities were measured in samples prepared from brains of rats of both sexes and various ages between 0 and 75 days, treated sc with 0.5 µg EB/100 g body weight in 0.1 ml olive oil/100 g body weight, 48 and 24 h before sacrifice. In females, EB treatment stimulated MnSOD activity on days 0 (66.1%, 8 (72.7% and 15 (81.7%. In males, the stimulatory effect of EB on MnSOD activity on day 0 (113.6% disappeared on day 8 and on days 15 and 45 it became inhibitory (40.3 and 30.5%, respectively. EB had no effect on the other age groups. The stimulatory effect of EB on CuZnSOD activity in newborn females (51.8% changed to an inhibitory effect on day 8 (38.4% and disappeared by day 45 when inhibition was detected again (48.7%. In males, the inhibitory effect on this enzyme was observed on days 0 (45.0% and 15 (28.9%, and then disappeared until day 60 when a stimulatory effect was observed (38.4%. EB treatment had no effect on the other age groups. The sensitivity of MnSOD to estradiol differed significantly between sexes during the neonatal and prepubertal period, whereas it followed a similar pattern thereafter. The sensitivity of CuZnSOD to estradiol differed significantly between sexes during most of the study period. Regression analysis showed that the sensitivity of MnSOD to this estrogen tended to decrease similarly in both sexes, whereas the sensitivity of CuZnSOD showed a significantly different opposite tendency in female and male rats. These are the first reports indicating hormonal modulation of antioxidant enzyme activities related to the developmental process.

  4. Centrifugally decoupling touchdown bearings

    Science.gov (United States)

    Post, Richard F

    2014-06-24

    Centrifugally decoupling mechanical bearing systems provide thin tensioned metallic ribbons contained in a support structure. This assembly rotates around a stationary shaft being centered at low speeds by the action of the metal ribbons. Tension springs are connected on one end to the ribbons and on the other end to the support structure. The ribbons pass through slots in the inner ring of the support structure. The spring preloading thus insures contact (or near-contact) between the ribbons and the shaft at rotation speeds below the transition speed. Above this speed, however, the centrifugal force on the ribbons produces a tensile force on them that exceeds the spring tensile force so that the ribbons curve outward, effectively decoupling them from mechanical contact with the shaft. They still remain, however, in position to act as a touchdown bearing in case of abnormally high transverse accelerations.

  5. Government Risk-Bearing

    CERN Document Server

    1993-01-01

    The u.s. government bulks large in the nation's financial markets. The huge volume of government-issued and -sponsored debt affects the pricing and volume ofprivate debt and, consequently, resource allocation between competing alternatives. What is often not fully appreciated is the substantial influence the federal government wields overresource allocation through its provisionofcreditandrisk-bearing services to the private economy. Because peopleand firms generally seekto avoid risk, atsomeprice they are willing to pay another party to assume the risk they would otherwise face. Insurance companies are a class of private-sector firms one commonly thinks of as providing these services. As the federal government has expanded its presence in the U.S. economy during this century, it has increasingly developed programs aimed at bearing risks that the private sector either would not take on at any price, or would take on but atapricethoughtto besogreatthatmostpotentialbeneficiarieswouldnotpurchase the coverage. To...

  6. Leakage-free journal bearings

    Science.gov (United States)

    Pinkus, O.; Etsion, I.

    1976-01-01

    A new concept of a journal bearing is developed which prevents side leakage of the lubricant, thus eliminating the need for sealing and collecting this leakage. The cooling of the bearing is accomplished by the prevailing circumferential flow. An analysis is performed and solutions are given for the bearing geometries and inlet pressures required to achieve the above purpose.

  7. Short communication: Use of a mixture of sodium nitrite, sodium benzoate, and potassium sorbate in aerobically challenged silages.

    Science.gov (United States)

    Knicky, Martin; Spörndly, Rolf

    2015-08-01

    Aerobic instability is still a common problem with many types of silages, particularly well-fermented silages. This study evaluated the effect of adding an additive mixture based on sodium nitrite, sodium benzoate, and potassium sorbate to a variety of crop materials on fermentation quality and aerobic stability of silages. Ensiling conditions were challenged by using a low packing density (104±4.3kg of dry matter/m(3)) of forage and allowing air ingression into silos (at 14 and 7 d before the end of the storage, for 8 h per event). Additive-treated silages were found to have significantly lower pH and reduced formation of ammonia-N, 2.3-butanediol, and ethanol compared with untreated control silages. Yeast growth was significantly reduced by additive treatment in comparison with untreated control silage. Consequently, additive-treated silages were considerably more aerobically stable (6.7 d) than untreated control silages (0.5 d). Overall, adding 5mL/kg of fresh crop of the additive based on sodium nitrite, sodium benzoate, and potassium sorbate reduced undesirable microorganisms in silages and thereby provided suitable ensiling conditions and prolonged aerobic stability, even under air-challenged laboratory ensiling conditions.

  8. Elucidation of the thermophilic phenol biodegradation pathway via benzoate during the anaerobic digestion of municipal solid waste.

    Science.gov (United States)

    Hoyos-Hernandez, Carolina; Hoffmann, Marieke; Guenne, Angeline; Mazeas, Laurent

    2014-02-01

    Anaerobic digestion makes it possible to valorize municipal solid waste (MSW) into biogas and digestate which are, respectively, a renewable energy source and an organic amendment for soil. Phenols are persistent pollutants present in MSW that can inhibit the anaerobic digestion process and have a toxic effect on microbiota if they are applied to soil together with digestate. It is then important to define the operational conditions of anaerobic digestion which allow the complete degradation of phenol. In this context, the fate of phenol during the anaerobic digestion of MSW at 55°C was followed using an isotopic tracing approach ((13)C6-phenol) in experimental microcosms with inoculum from an industrial thermophilic anaerobic digester. With this approach, it was possible to demonstrate the complete phenol biodegradation into methane and carbon dioxide via benzoate. Benzoate is known to be a phenol metabolite under mesophilic conditions, but in this study it was found for the first time to be a phenol degradation product at thermophilic temperature.

  9. Effectiveness of sodium benzoate as a freshwater low toxicity antifoulant when dispersed in solution and entrapped in silicone coatings.

    Science.gov (United States)

    Haque, Haroon; Cutright, Teresa J; Newby, Bi-Min Zhang

    2005-01-01

    The traditional solution for preventing organisms from attaching to submerged surfaces is to apply antifouling coatings or biocides. Based on the varied defence mechanisms exhibited by biofilms, the antifoulant needs to prevent bacterial attachment during the early stages of biofilm formation. The potential of benzoic acid and sodium benzoate (NaB) as antifoulants for deterring freshwater bacterial attachment was evaluated with the antifoulants dispersed in solution or entrapped in silicone coatings. Effectiveness was based on the decrease in microbial attachment, limited toxicity, and minimum alteration of the properties of the coatings. The optimal NaB concentration when dispersed in solution, 700 mg l-1, resulted in a biofilm surface coverage of only 3.34% after four weeks. The model silicone, Sylgard 184, demonstrated a better overall performance than the commercial coating, RTV11. Sylgard 184 containing sodium benzoate had 41-52% less biofilm in comparison to the control Sylgard 184, whereas both the control and NaB-entrapped RTV11 coatings had significant biofilm coverage.

  10. [Analysis of preservatives used in cosmetic products: salicylic acid, sodium benzoate, sodium dehydroacetate, potassium sorbate, phenoxyethanol, and parabens].

    Science.gov (United States)

    Ikarashi, Yoshiaki; Uchino, Tadashi; Nishimura, Tetsuji

    2010-01-01

    Preservatives are used to inhibit the growth of microorganisms in cosmetic products. The Japanese standards for cosmetics set restrictions on the maximum amount of each preservative added to cosmetics as per the purpose of use of cosmetics. For the investigation into the actual conditions of commonly used preservatives in commercial cosmetics, we analyzed parabens, phenoxyethanol, sodium benzoate, sodium dehydroacetate, salicylic acid, and potassium sorbate by high-performance liquid chromatography (HPLC). Twenty-one samples were obtained from cosmetic product manufacturers located in 14 prefectures in Japan. Among different acid- and salt-based preservatives, sodium benzoate was observed to have been used in many products. These acid- and salt-based preservatives were used with parabens in personal washing products, such as shampoo and soap. The labels of two of the cosmetic product samples displayed inaccurate ingredient information, that is, a preservative other than the one used in the corresponding product was listed on them. The amount of preservatives used did not exceed regulatory limits in any of the analyzed samples.

  11. Anti-backlash gear bearings

    Science.gov (United States)

    Vranish, John M. (Inventor)

    2009-01-01

    A gear bearing having a first gear and a second gear, each having a plurality of teeth. Each gear operates on two non-parallel surfaces of the opposing gear teeth to perform both gear and bearing functions simultaneously. The gears are moving at substantially the same speed at their contact points. The gears may be roller gear bearings or phase-shifted gear bearings, and may be arranged in a planet/sun system or used as a transmission. One preferred embodiment discloses and describes an anti-backlash feature to counter ''dead zones'' in the gear bearing movement.

  12. Damping Bearings In High-Speed Turbomachines

    Science.gov (United States)

    Von Pragenau, George L.

    1994-01-01

    Paper presents comparison of damping bearings with traditional ball, roller, and hydrostatic bearings in high-speed cryogenic turbopumps. Concept of damping bearings described in "Damping Seals and Bearings for a Turbomachine" (MFS-28345).

  13. Dispersive liquid-liquid microextraction followed by high-performance liquid chromatography for determination of benzoate and sorbate in yogurt drinks and method optimization by central composite design.

    Science.gov (United States)

    Kamankesh, Marzieh; Mohammadi, Abdorreza; Tehrani, Zohreh Modarres; Ferdowsi, Roohallah; Hosseini, Hedayat

    2013-05-15

    A new method based on dispersive liquid-liquid microextraction (DLLME) followed by high-performance liquid chromatography (HPLC) for determination of benzoate and sorbate salts in yogurt drinks was developed. The effective parameters in DLLME process, including volume of extraction and disperser solvents, pH and salt effect, were optimized using response surface methodology (RSM) based on central composite design. The yogurt drink samples were extracted using NaOH and Carrez solutions (potassium hexaferrocyanide and zinc acetate) were used for sedimentation of proteins. For DLLME, a mixture of extraction solvent (1-octanol) and disperser solvent (ethanol) was rapidly injected into the sample solution by syringe and cloudy solution is formed. Subsequently, the upper 1-octanol layer was analyzed by HPLC. The detection limits for benzoate and sorbate were 0.06 ng mL(-1) and 0.15 ng mL(-1), respectively. The relative standard deviations (RSD) for seven analyses were 4.96% for benzoate and 4.58% for sorbate. The proposed method demonstrated good linearity and high enrichment factor. A clean separation and good chromatogram is readily achieved without the presence of matrix interference. A comparison of this method with previous methods demonstrated that the proposed method is an accurate, rapid and reliable sample-pretreatment method that gives very good enrichment factors and detection limits for extracting and determining sorbate and benzoate in yogurt drink samples.

  14. The efficacy of emamectin benzoate against infestations of Lepeophtheirus salmonis on farmed Atlantic salmon (Salmo salar L in Scotland, 2002-2006.

    Directory of Open Access Journals (Sweden)

    Fiona Lees

    Full Text Available BACKGROUND: Infestations of the parasitic copepod Lepeophtheirus salmonis, commonly referred to as sea lice, represent a major challenge to commercial salmon aquaculture. Dependence on a limited number of theraputants to control such infestations has led to concerns of reduced sensitivity in some sea lice populations. This study investigates trends in the efficacy of the in-feed treatment emamectin benzoate in Scotland, the active ingredient most widely used across all salmon producing regions. METHODOLOGY/PRINCIPAL FINDINGS: Study data were drawn from over 50 commercial Atlantic salmon farms on the west coast of Scotland between 2002 and 2006. An epi-informatics approach was adopted whereby available farm records, descriptive epidemiological summaries and statistical linear modelling methods were used to identify factors that significantly affect sea lice abundance following treatment with emamectin benzoate (SLICE(R, Schering Plough Animal Health. The results show that although sea lice infestations are reduced following the application of emamectin benzoate, not all treatments are effective. Specifically there is evidence of variation across geographical regions and a reduction in efficacy over time. CONCLUSIONS/SIGNIFICANCE: Reduced sensitivity and potential resistance to currently available medicines are constant threats to maintaining control of sea lice populations on Atlantic salmon farms. There is a need for on-going monitoring of emamectin benzoate treatment efficacy together with reasons for any apparent reduction in performance. In addition, strategic rotation of medicines should be encouraged and empirical evidence for the benefit of such strategies more fully evaluated.

  15. 长期烫吸安钠咖对肝功能的影响%EFFECT OF LONG- TERM USE OF CAFFEINE SODIUM BENZOATE ON LIVER FUNCTION

    Institute of Scientific and Technical Information of China (English)

    黄永清; 张宪武; 王志纲

    2011-01-01

    目的:探讨长期烫吸安钠咖对肝功的影响.方法:应用MoDULAR P800仪器,对烫吸安钠咖组36例及正常对照组14例测定肝功情况,对结果进行比较分析.结果:与对照组比较,烫吸安钠咖组的总胆红素含量低,在统计学上存在显著性差异(P<0.01);谷丙转氨酶、肌酐含量高,在统计学上存在差异(P<0.05).结论:长期烫吸安钠咖对肝功有一定的影响.%Objective :To observe the effect of long - term use of caffeine sodium benzoate on liver function. Methods:To compare the liver function of long - term users of caffeine sodium benzoate with that of the control group by MoDULAR P800 made in USA. Results: Compared with the control, the bilirubin total in the long - term users of caffeine sodium benzoate was lower, showing significant difference (P < 0.01), the glutamate pyruvate transaminase, creatinine were higher(P < 0.05). Conclusion: Long - term use of caffeine sodium benzoate can influence the users' liver function to some extent.

  16. Aerospace applications of magnetic bearings

    Science.gov (United States)

    Downer, James; Goldie, James; Gondhalekar, Vijay; Hockney, Richard

    1994-01-01

    Magnetic bearings have traditionally been considered for use in aerospace applications only where performance advantages have been the primary, if not only, consideration. Conventional wisdom has been that magnetic bearings have certain performance advantages which must be traded off against increased weight, volume, electric power consumption, and system complexity. These perceptions have hampered the use of magnetic bearings in many aerospace applications because weight, volume, and power are almost always primary considerations. This paper will review progress on several active aerospace magnetic bearings programs at SatCon Technology Corporation. The magnetic bearing programs at SatCon cover a broad spectrum of applications including: a magnetically-suspended spacecraft integrated power and attitude control system (IPACS), a magnetically-suspended momentum wheel, magnetic bearings for the gas generator rotor of a turboshaft engine, a vibration-attenuating magnetic bearing system for an airborne telescope, and magnetic bearings for the compressor of a space-rated heat pump system. The emphasis of these programs is to develop magnetic bearing technologies to the point where magnetic bearings can be truly useful, reliable, and well tested components for the aerospace community.

  17. Nanoprecipitation in bearing steels

    Energy Technology Data Exchange (ETDEWEB)

    Barrow, A.T.W. [SKF University Technology Centre, Department of Materials Science and Metallurgy, University of Cambridge, Cambridge CB2 3QZ (United Kingdom); Rivera-Diaz-del-Castillo, P.E.J., E-mail: pejr2@cam.ac.uk [SKF University Technology Centre, Department of Materials Science and Metallurgy, University of Cambridge, Cambridge CB2 3QZ (United Kingdom)

    2011-11-15

    {theta}-phase is the main hardening species in bearing steels and appears in both martensitically and bainitically hardened microstructures. This work presents a survey of the microstrucural features accompanying nanoprecipitation in bearing steels. Nanoprecipitate structures formed in 1C-1.5Cr wt.% with additions of Cr, Mn, Mo, Si and Ni are studied. The work is combined with thermodynamic calculations and neural networks to predict the expected matrix composition, and whether this will transform martensitically or bainitically. Martensite tetragonality, composition and the amount of retained austenite are related to hardness and the type of nanoprecipitate structures in martensitic grades. The {theta}-phase volume fraction, the duration of the bainite to austenite transformation and the amount of retained austenite are related to hardness and a detailed quantitative description of the precipitate nanostructures. Such description includes compositional studies using energy-dispersive spectroscopy, which shows that nanoprecipitate formation takes place under paraequilibrium. Special attention is devoted to a novel two-step bainite tempering process which shows maximum hardness; we prove that this is the most effective process for incorporating solute into the precipitates, which are finer than those resulting from one-step banitic transformation processes.

  18. Supramolecular Complexation Behavior of Novel Cyclotrivera-trylene Derivatives with Benzoate Pendants with C60

    Institute of Scientific and Technical Information of China (English)

    ZHAN Hao-Oiang; JIANG Xi-Kui; LI Zhan-Ting

    2001-01-01

    Four novel cyclotriveratrylene (CTV) derivatives with threebenzoate pendants bearing different aliphatic chains have been prepared in good yields,starting from.CTV.The complexa-tion behavior of these CTV derivatives towards C60 in arene solvents has been measured by UV-visible spectroscopy and high complexation constants are obtained.It is observed the me complexation is promoted by introducing methyl ester groups to the aromatic pendants, while this pro-moting effect is reduced when the methyl groups are replaced by longer alkyl groups.

  19. Computational design of rolling bearings

    CERN Document Server

    Nguyen-Schäfer, Hung

    2016-01-01

    This book comprehensively presents the computational design of rolling bearings dealing with many interdisciplinary difficult working fields. They encompass elastohydrodynamics (EHD), Hertzian contact theory, oil-film thickness in elastohydrodynamic lubrication (EHL), bearing dynamics, tribology of surface textures, fatigue failure mechanisms, fatigue lifetimes of rolling bearings and lubricating greases, Weibull distribution, rotor balancing, and airborne noises (NVH) in the rolling bearings. Furthermore, the readers are provided with hands-on essential formulas based on the up-to-date DIN ISO norms and helpful examples for computational design of rolling bearings. The topics are intended for undergraduate and graduate students in mechanical and material engineering, research scientists, and practicing engineers who want to understand the interactions between these working fields and to know how to design the rolling bearings for automotive industry and many other industries.

  20. Grease lubrication in rolling bearings

    CERN Document Server

    Lugt, Piet M

    2012-01-01

    The definitive book on the science of grease lubrication for roller and needle bearings in industrial and vehicle engineering. Grease Lubrication in Rolling Bearings provides an overview of the existing knowledge on the various aspects of grease lubrication (including lubrication systems) and the state of the art models that exist today. The book reviews the physical and chemical aspects of grease lubrication, primarily directed towards lubrication of rolling bearings. The first part of the book covers grease composition, properties and rheology, including thermal

  1. Di-μ-iodido-bis(iodido{methyl 4-[(pyridin-2-ylmethylideneamino]benzoate-κ2N,N′}cadmium

    Directory of Open Access Journals (Sweden)

    Tushar S. Basu Baul

    2013-11-01

    Full Text Available The complete binuclear molecule of the title compound, [Cd2I4(C14H12N2O22], is generated by the application of a centre of inversion. The Cd—I bond lengths of the central core are close and uniformly longer than the exocyclic Cd—I bond. The coordination sphere of the CdII atom is completed by two N atoms of a chelating methyl 4-[(pyridin-2-ylmethylideneamino]benzoate ligand, and is based on a square pyramid with the terminal I atom in the apical position. The three-dimensional crystal packing is stabilized by C—H...O and C—H...π interactions, each involving the pyridine ring.

  2. Degradation of organic ultraviolet filter diethylamino hydroxybenzoyl hexyl benzoate in aqueous solution by UV/H2O2.

    Science.gov (United States)

    Gong, Ping; Yuan, Haixia; Zhai, Pingping; Dong, Wenbo; Li, Hongjing

    2015-07-01

    Steady-state and transient-state photolysis experiments were conducted to investigate the degradation of organic ultraviolet filter diethylamino hydroxybenzoyl hexyl benzoate (DHHB) in the aqueous solution by UV/H2O2. Results showed that the obvious degradation of DHHB was not observed under UV irradiation (λ = 254 nm), and the DHHB degradation was conducted due to the oxidation by hydroxyl radical (HO·). While the H2O2 concentration was between 0.05 and 0.10 mol L(-1), the highest DHHB degradation efficiency was obtained. The lower solution pH favored the transformation of DHHB, and the coexisting Cl(-) and NO3(-) ions slightly enhanced the conversion. The degradation of DHHB by HO· followed a pseudo-first-order kinetic model with different initial DHHB concentrations. By intermediate products during DHHB oxidation and laser flash photolysis spectra analysis, a primary degradation pathway was proposed.

  3. Novel 3-D Supramolecular Architectures Constructed from Zn2+ ions, Oxybis(4-benzoate) and Di(2-pyridyl)amine Ligands

    Institute of Scientific and Technical Information of China (English)

    TANG Long; LI Dong-Sheng; FU Feng; WANG Ji-Jiang; HU Huai-Ming; WANG Yao-Yu

    2007-01-01

    Using the V-shaped oba dianions as bridging ligands and dpa molecules as terminal ligands, a new 1D helical coordination-polymeric chain, [Zn(oba)(dpa)]n [oba=oxybis(4-benzoate), dpa=di(2-pyridyl)amine], was synthesized and characterized by single-crystal X-ray diffraction, elemental analyses, UV-Vis and IR spectra, and TGA analysis. X-ray structural analysis revealed that, oba and dpa ligands played an important role in the self-assembly of the helical chains by providing potential supramolecular recognition sites for π-π aromatic stacking and hydrogen-bond interactions, resulting in the self-assembly of the (4,4) networks to give a 3-D supramolecular framework.The photoluminescence properties of the title compound were also investigated, showing intense blue photoluminescence properties at room temperature.

  4. Design, synthesis, molecular docking studies and in vitro screening of ethyl 4-(3-benzoylthioureido) benzoates as urease inhibitors.

    Science.gov (United States)

    Saeed, Aamer; Khan, Muhammad Siraj; Rafique, Hummera; Shahid, Mohammad; Iqbal, Jamshed

    2014-02-01

    Thioureas are exceptionally versatile building blocks towards the synthesis of wide variety of heterocyclic systems, which also possess extensive range of pharmacological activities. The substituted benzoic acids were converted into corresponding acid chlorides, these acid chlorides were then treated with potassium thiocyanate in acetone and then the reaction mixture was refluxed for 1-2h afford ethyl 4-(3-benzoylthioureido)benzoates thioureas in good yields. All the newly synthesized compounds were evaluated for their urease inhibitory activities and were found to be potent inhibitors of urease enzyme. Compounds 1f and 1g were identified as the most potent urease inhibitors (IC50 0.21 and 0.13 μM, respectively), and was 100-fold more potent than the standard inhibitors. Further molecular docking studies were carried out using the crystal structure of urease to find out the binding mode of the inhibitors with the enzyme.

  5. Growth and characterization of nonlinear optical single crystals: bis(cyclohexylammonium) terephthalate and cyclohexylammonium para-methoxy benzoate

    Indian Academy of Sciences (India)

    P Sathya; M Anantharaja; N Elavarasu; R Gopalakrishnan

    2015-09-01

    Bis(cyclohexylammonium) terephthalate (BCT) and cyclohexylammonium 4-methoxy benzoate (C4MB) single crystals were successfully grown by the slow evaporation solution growth technique. The harvested crystals were subjected to single-crystal X-ray diffraction, spectral, optical, thermal and mechanical studies in order to evaluate physiochemical properties. The Kurtz and Perry technique for second harmonic generation (SHG) study revealed that the powdered materials of BCT and C4MB exhibit SHG efficiency 0.2 times less and 1.3 times greater than that of standard reference material potassium dihydrogen phosphate. C4MB crystal exhibits high efficiency than BCT, because of methoxy group substituted in the para position of phenyl ring. With high SHG efficiency and thermal stability para substituted C4MB crystal will be a potential candidate for optical device fabrication.

  6. Cyanines Bearing Quaternary Azaaromatic Moieties

    OpenAIRE

    Sbliwa, Wanda; Matusiak, Grazyna; Bachowska, Barbara

    2006-01-01

    Selected cyanines bearing quaternary azaaromatic moieties are presented, showing their monomers, dimers and polymers, as well as their possible applications. Cyanines having NLO properties are also briefly described.

  7. Hydrostatic and hybrid bearing design

    CERN Document Server

    Rowe, W B

    1983-01-01

    Hydrostatic and Hybrid Bearing Design is a 15-chapter book that focuses on the bearing design and testing. This book first describes the application of hydrostatic bearings, as well as the device pressure, flow, force, power, and temperature. Subsequent chapters discuss the load and flow rate of thrust pads; circuit design, flow control, load, and stiffness; and the basis of the design procedures and selection of tolerances. The specific types of bearings, their design, dynamics, and experimental methods and testing are also shown. This book will be very valuable to students of engineering des

  8. Administration of estradiol benzoate before insemination could skew secondary sex ratio toward males in Holstein dairy cows.

    Science.gov (United States)

    Emadi, S R; Rezaei, A; Bolourchi, M; Hovareshti, P; Akbarinejad, V

    2014-07-01

    The present study was conducted to investigate the effect of estradiol benzoate administration before insemination on secondary sex ratio (proportion of male calves at birth) in Holstein dairy cows. Cows (n = 1,647) were randomly assigned to 2 experimental groups by parity over a 1-yr period. Cows in the control group (n = 827; 232 primiparous and 595 multiparous cows) received 2 administrations of PGF2α (500 μg) 14 d apart, started at 30 to 35 d postpartum. Twelve d after the second PGF2α injection, cows received GnRH (100 μg), followed by administration of PGF2α 7 d later. Cows in the treatment group (n = 820; 238 primiparous and 582 multiparous cows) received the same hormonal administrations as the cows in the control group. Additionally, cows in the treatment group received estradiol benzoate (1 mg) 1 d after the third PGF2α injection. Estrus detection by visual observation was started 1 d after the third PGF2α injection and after estradiol administration in the control (for 6 d) and treatment (for 36 h) groups, respectively. Artificial insemination was carried out 12 h after observation of standing estrus. Exposure of cows to heat stress at conception was determined based on temperature-humidity index. Estrus detection rate was lower in primiparous than in multiparous cows (P heat stress diminished heat detection rate and fertility (P calves being male in Holstein dairy cows. Moreover, the results showed that cows exposed to heat stress around conception had diminished fertility and increased secondary sex ratio.

  9. Permanent-Magnet Meissner Bearing

    Science.gov (United States)

    Robertson, Glen A.

    1994-01-01

    Permanent-magnet meissner bearing features inherently stable, self-centering conical configuration. Bearing made stiffer or less stiff by selection of magnets, springs, and spring adjustments. Cylindrical permanent magnets with axial magnetization stacked coaxially on rotor with alternating polarity. Typically, rare-earth magnets used. Magnets machined and fitted together to form conical outer surface.

  10. High-Performance Ball Bearing

    Science.gov (United States)

    Bursey, Roger W., Jr.; Haluck, David A.; Olinger, John B.; Owen, Samuel S.; Poole, William E.

    1995-01-01

    High-performance bearing features strong, lightweight, self-lubricating cage with self-lubricating liners in ball apertures. Designed to operate at high speed (tens of thousands of revolutions per minute) in cryogenic environment like liquid-oxygen or liquid-hydrogen turbopump. Includes inner race, outer race, and cage keeping bearing balls equally spaced.

  11. Superconducting bearings for flywheel applications

    DEFF Research Database (Denmark)

    Abrahamsen, A.B.

    2001-01-01

    A literature study on the application of superconducting bearings in energy storage flywheel systems. The physics of magnetic levitation and superconductors are presented in the first part of the report, followed by a discussion of the literature found onthe applications of superconducting bearings...

  12. What about the Javan Bear?

    NARCIS (Netherlands)

    Jentink, F.A.

    1898-01-01

    The other day I read in a dutch popular periodical a paper dealing with the different species of Bears and their geographical distribution. To my great surprise the Malayan Bear was mentioned from Java: the locality Java being quite new to me I wrote to the author of that paper and asked him some in

  13. Geophagy by yellowstone grizzly bears

    Science.gov (United States)

    Mattson, D.J.; Green, G.I.; Swalley, R.

    1999-01-01

    We documented 12 sites in the Yellowstone ecosystem where grizzly bears (Ursus arctos horribilis) had purposefully consumed soil (an activity known as geophagy). We also documented soil in numerous grizzly bear feces. Geophagy primarily occurred at sites barren of vegetation where surficial geology had been modified by geothermal activity. There was no evidence of ungulate use at most sites. Purposeful consumption of soil by bears peaked first from March to May and again from August to October, synchronous with peaks in consumption of ungulate meat and mushrooms. Geophageous soils were distinguished from ungulate mineral licks and soils in general by exceptionally high concentrations of potassium (K) and high concentrations of magnesium (Mg) and sulphur (S). Our results do not support the hypotheses that bears were consuming soil to detoxify secondary compounds in grazed foliage, as postulated for primates, or to supplement dietary sodium, as known for ungulates. Our results suggest that grizzly bears could have been consuming soil as an anti-diarrheal.

  14. Influence of flavone extract from cultivated saussurea on learning and memory in a mouse model of Alzheimer's disease A comparison with estradiol benzoate

    Institute of Scientific and Technical Information of China (English)

    Weiqiang Chen; Shuiming Gong; Yan Li; Ming Li; Zemin Yang; Lirong Zhang

    2011-01-01

    The present study established a mouse model of Alzheimer's disease, and investigated the effects of treatment with flavone extract from artificially cultivated saussurea. A positive control group was treated with estradiol benzoate, and learning and memory ability were examined in the 8-arm radial maze. The learning and recognition ability of mice with Alzheimer's disease treated with flavone extract was significantly improved and the number of hippocampal neurons was significantly increased in the flavone-treated and positive control groups compared with the model group. The results indicate that flavone extract from artificially cultivated saussurea can improve learning and memory deficits in mice with Alzheimer's disease, exerting effects similar to those of estradiol benzoate.

  15. Eastern slopes grizzly bear project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-01-01

    The cumulative effects of human activities on the grizzly bears in the central Canadian Rockies are not well known. As a result, a project was initiated in 1994 to address the urgent requirement for accurate scientific information on the habitat and populations of grizzly bears in the area of the Banff National Park and Kananaskis Country. This area is probably the most heavily used and developed area where the grizzly still survives. The information gathered throughout the course of this study will be used to better protect and manage the bears and other sensitive carnivores in the region. Using telemetry, researchers are monitoring 25 grizzly bears which were radio-collared in a 22,000 square-kilometer area in the upper Bow Valley drainage of the eastern Alberta slopes. The researchers involved in the project are working with representatives from Husky Oil and Talisman Energy on the sound development of the Moose Mountain oil and gas field without adversely affecting the grizzly bear population. Information collected over seven years indicated that the grizzly bears have few and infrequent offspring. Using the information gathered so far, the location of the Moose Mountain to Jumping Pound pipeline was carefully selected, since the bears recover very slowly from high mortality, and also considering that the food and cover had already been compromised by the high number of roads, trails and other human activities in the area. The status of the population and habitat of the grizzly bear will be assessed upon the conclusion of the field research phase in 2001. Models will be updated using the data obtained during eight years and will assist in the understanding of complex variables that affect grizzly bears.

  16. EFFECT OF BEARING MACROGEOMETRY ON BEARING PERFORMANCE IN ELASTOHYDRODYNAMIC LUBRICATION

    Directory of Open Access Journals (Sweden)

    Emin GÜLLÜ

    2000-01-01

    Full Text Available During manufacturing, ideal dimension and mutual positioning of machine elements proposed in project desing can be achieved only within certain range of tolerances. These tolerances, being classified in two groups, related to micro and macro geometry of machine elements, don't have to effect the functioning of these elements. So, as for all machine elements, investigation of the effects of macro and micro tolerances for journal bearings is important. In this study, we have investigated the effect of macro geometric irregularities of journal bearings on performance characteristics. In this regard, we have studied the change of bearing performance in respect to deviation from ideal circle for an elliptic shaft with small ovality rolling in circular journal bearing.

  17. Bears, Big and Little. Young Discovery Library Series.

    Science.gov (United States)

    Pfeffer, Pierre

    This book is written for children 5 through 10. Part of a series designed to develop their curiosity, fascinate them and educate them, this volume describes: (1) the eight species of bears, including black bear, brown bear, grizzly bear, spectacled bear, sun bear, sloth bear, polar bear, and giant panda; (2) geographical habitats of bears; (3)…

  18. One-pot, four-component synthesis of pyrano[2,3-c]pyrazoles catalyzed by sodium benzoate in aqueous medium

    Directory of Open Access Journals (Sweden)

    Hamzeh Kiyani

    2013-10-01

    Full Text Available An efficient, green, and facile four-component reaction for the preparation of pyrano[2,3-c]pyrazole derivatives through the condensation reaction of aryl aldehydes, ethyl acetoacetate, malononitrile, and hydrazine hydrate or phenyl hydrazine in the presence of commercially available organocatalyst sodium benzoate under aqueous condition is reported. The products are produced with high yields and in shorter reaction times. It also is mild, safe, green and environmental friendly.

  19. Siderophore-Producing Bacteria from a Sand Dune Ecosystem and the Effect of Sodium Benzoate on Siderophore Production by a Potential Isolate

    Directory of Open Access Journals (Sweden)

    Teja Gaonkar

    2012-01-01

    Full Text Available Bioremediation in natural ecosystems is dependent upon the availability of micronutrients and cofactors, of which iron is one of the essential elements. Under aerobic and alkaline conditions, iron oxidizes to Fe+3 creating iron deficiency. To acquire this essential growth-limiting nutrient, bacteria produce low-molecular-weight, high-affinity iron chelators termed siderophores. In this study, siderophore-producing bacteria from rhizosphere and nonrhizosphere areas of coastal sand dunes were isolated using a culture-dependent approach and were assigned to 8 different genera with the predominance of Bacillus sp. Studies on the ability of these isolates to grow on sodium benzoate revealed that a pigmented bacterial culture TMR2.13 identified as Pseudomonas aeruginosa showed growth on mineral salts medium (MSM with 2% of sodium benzoate and produced a yellowish fluorescent siderophore identified as pyoverdine. This was inhibited above 54 μM of added iron in MSM with glucose without affecting growth, while, in presence of sodium benzoate, siderophore was produced even up to the presence of 108 μM of added iron. Increase in the requirement of iron for metabolism of aromatic compounds in ecosystems where the nutrient deficiencies occur naturally would be one of the regulating factors for the bioremediation process.

  20. Determination of Rizatriptan Benzoate by Potentiometric Titration%电位滴定法测定苯甲酸利扎曲普坦的含量

    Institute of Scientific and Technical Information of China (English)

    于小琴; 陈雅男; 臧晓红

    2016-01-01

    Objective To establish a potentiometric titration method for determination of rizatriptan benzoate. Methods The samples was dissolved in 40 mL of glacial acetic acid and 5 mL of acetic anhydride were titrated potentiometrically with 0.1 mol/L perchloric acid solution. And blank test calibration was performed for titration results.Results The content of rizatriptan benzoate was 100.21 %, withRSD of 0.2 %.ConclusionThis method can be simple and accurate, and suitable for the determination of rizatriptan benzoate.%目的:建立电位滴定法测定苯甲酸利扎曲普坦的含量的方法。方法以冰醋酸40 mL和醋酐5 mL溶解样品后,采用电位滴定法用高氯酸滴定液(0.1 mol/L)滴定,并将滴定结果用空白试验校正。结果测得的苯甲酸利扎曲普坦样品的含量为100.21%,RSD为0.2%。结论该方法操作简单、准确度高,适合苯甲酸利扎曲普坦含量的检测。

  1. Detection of emamectin benzoate tolerance emergence in different life stages of sea lice, Lepeophtheirus salmonis, on farmed Atlantic salmon, Salmo salar L.

    Science.gov (United States)

    Jones, P G; Hammell, K L; Gettinby, G; Revie, C W

    2013-03-01

    Emamectin benzoate has been used to treat sea lice, Lepeophtheirus salmonis, infestations on farmed Atlantic salmon, Salmo salar. Recent evidence suggests a reduction in effectiveness in some locations. A major challenge in the detection of tolerance emergence can be the typically low proportion of resistant individuals in a population during the early phases. The objectives of this study were to develop a method for determining differences in temporal development of tolerance between sea lice life stages and to explore how these differences might be used to improve the monitoring of treatment effectiveness in a clinical setting. This study examined two data sets based on records of sea lice abundance following emamectin benzoate treatments from the west coast of Scotland (2002-2006) and from New Brunswick, Canada (2004-2008). Life stages were categorized into two groups (adult females and the remaining mobile stages) to examine the trends in mean abundance and treatment effectiveness. Differences in emamectin benzoate effectiveness were found between the two groups by year and location, suggesting that an important part of monitoring drug resistance development in aquatic ectoparasites may be the need to focus on key life stages.

  2. Siderophore-producing bacteria from a sand dune ecosystem and the effect of sodium benzoate on siderophore production by a potential isolate.

    Science.gov (United States)

    Gaonkar, Teja; Nayak, Pramoda Kumar; Garg, Sandeep; Bhosle, Saroj

    2012-01-01

    Bioremediation in natural ecosystems is dependent upon the availability of micronutrients and cofactors, of which iron is one of the essential elements. Under aerobic and alkaline conditions, iron oxidizes to Fe(+3) creating iron deficiency. To acquire this essential growth-limiting nutrient, bacteria produce low-molecular-weight, high-affinity iron chelators termed siderophores. In this study, siderophore-producing bacteria from rhizosphere and nonrhizosphere areas of coastal sand dunes were isolated using a culture-dependent approach and were assigned to 8 different genera with the predominance of Bacillus sp. Studies on the ability of these isolates to grow on sodium benzoate revealed that a pigmented bacterial culture TMR2.13 identified as Pseudomonas aeruginosa showed growth on mineral salts medium (MSM) with 2% of sodium benzoate and produced a yellowish fluorescent siderophore identified as pyoverdine. This was inhibited above 54 μM of added iron in MSM with glucose without affecting growth, while, in presence of sodium benzoate, siderophore was produced even up to the presence of 108 μM of added iron. Increase in the requirement of iron for metabolism of aromatic compounds in ecosystems where the nutrient deficiencies occur naturally would be one of the regulating factors for the bioremediation process.

  3. Modeling the efficacy of triplet antimicrobial combinations: yeast suppression by lauric arginate, cinnamic acid, and sodium benzoate or potassium sorbate as a case study.

    Science.gov (United States)

    Dai, Yumei; Normand, Mark D; Weiss, Jochen; Peleg, Micha

    2010-03-01

    The growth of four spoilage yeasts, Saccharomyces cerevisiae, Zygosaccharomyces bailii, Brettanomyces bruxellensis, and Brettanomyces naardenensis, was inhibited with three-agent (triplet) combinations of lauric arginate, cinnamic acid, and sodium benzoate or potassium sorbate. The inhibition efficacy was determined by monitoring the optical density of yeast cultures grown in microtiter plates for 7 days. The relationship between the optical density and the sodium benzoate and potassium sorbate concentrations followed a single-term exponential decay model. The critical effective concentration was defined as the concentration at which the optical density was 0.05, which became an efficacy criterion for the mixtures. Critical concentrations of sodium benzoate or potassium sorbate as a function of the lauric arginate and cinnamic acid concentrations were then fitted with an empirical model that mapped three-agent combinations of equal efficacy. The contours of this function are presented in tabulated form and as two- and three-dimensional plots. Triplet combinations were highly effective against all four spoilage yeasts at three practical pH levels, especially at pH 3.0. The triplet combinations were particularly effective for inhibiting growth of Z. bailii, and combinations containing potassium sorbate had synergistic activities. The equal efficacy concentration model also allowed tabulation of the cost of the various combinations of agents and identification of those most economically feasible.

  4. Synthesis, structure and temperature-depended 2D IR correlation spectroscopy of an organo-bismuth benzoate with 1,10-phenanthroline

    Science.gov (United States)

    Sun, Yan-Qiong; Zhong, Jie-Cen; Liu, Le-Hui; Qiu, Xing-Tai; Chen, Yi-Ping

    2016-11-01

    An organo-bismuth benzoate with phen as auxiliary ligand, [Bi(phen)(C6H5COO)(C6H4COO)] (1) (phen = 1,10-phenanthroline) has been hydrothermally synthesized from bismuth nitrate, 2-mercaptonbenzoic acid with phen as auxiliary ligand and characterized by single-crystal X-ray diffraction, elemental analyses, PXRD, IR spectra, TG analyses, temperature-depended 2D-IR COS (two-dimensional infrared correlation spectroscopy). Interestingly, benzoate anions in 1 came from the desulfuration reaction of 2-mercaptonbenzoic acid under hydrothermal condition. Compound 1 is a discrete organo-bismuth compound with benzoate and phen ligands. The offset face-to-face π-π stacking interactions and C-H⋯O hydrogen bonds link the isolate complex into a 3D supramolecular network. The temperature-depended 2D-IR COS indicates that the stretching vibrations of Cdbnd C/Cdbnd N of aromatic rings and Cdbnd O bonds are sensitive to the temperature change.

  5. Myrmecophagy by Yellowstone grizzly bears

    Science.gov (United States)

    Mattson, D.J.

    2001-01-01

    I used data collected during a study of radio-marked grizzly bears (Ursus arctos horribilis) in the Yellowstone region from 1977 to 1992 to investigate myrmecophagy by this population. Although generally not an important source of energy for the bears (averaging 8 mm long) nested in logs over small ants (6 mm long) nested under stones. Optimal conditions for consumption of ants occurred on the warmest sites with ample substrate suitable for ant nests. For ants in mounds, this occurred at low elevations at non-forested sites. For ants in logs, this occurred at low elevations or on southerly aspects where there was abundant, large-diameter, well-decomposed woody debris under an open forest canopy. Grizzly bears selected moderately decomposed logs 4a??5 dm in diameter at midpoint. Ants will likely become a more important food for Yellowstone's grizzly bears as currently important foods decline, owing to disease and warming of the regional climate.

  6. Segmented Hybrid Gasostatic Bearing Optimization

    Directory of Open Access Journals (Sweden)

    Prodan Nikolay Vasilevich

    2014-07-01

    Full Text Available The purpose of research-development of methods of numerical optimization rotatable support pads gasostatic hybrid bearing. In the world‘s aerospace engineering the gas-dynamic bearings are currently most common. They are characterized by the supporting layer of different designs, which ensures the workability of the rotors during starts and stops. The main problem of this bearing type, apart from the construction complexity is the wear of this supporting layer. Gas-static bearing has no such defect, since there is no physical contact between solid surfaces. This study presents the results of the hybrid bearing’s calculation, combining both technologies. The slotted nozzle of non-conventional shape that mirrors the solution of Reynolds equation’s isoline is studied. The dependences of the main parameters on the speed of the shaft’s rotation are discussed. The aerodynamic resistance of pads for different regimes of operation is investigated.

  7. Gas bearing operates in vacuum

    Science.gov (United States)

    Perkins, G. S.

    1975-01-01

    Bearing has restrictions to reduce air leaks and is connected to external pumpout facility which removes exhausted air. Token amount of air which is lost to vacuum is easily removed by conventional vacuum pump.

  8. Mixed-mu superconducting bearings

    Energy Technology Data Exchange (ETDEWEB)

    Hull, John R. (Hinsdale, IL); Mulcahy, Thomas M. (Western Springs, IL)

    1998-01-01

    A mixed-mu superconducting bearing including a ferrite structure disposed for rotation adjacent a stationary superconductor material structure and a stationary permanent magnet structure. The ferrite structure is levitated by said stationary permanent magnet structure.

  9. Nonlinear Control of Magnetic Bearings

    Institute of Scientific and Technical Information of China (English)

    Khac Duc Do; Dang Hoe Nguyen; Thanh Binh Nguyen

    2010-01-01

    In this paper, recent results controling nonlinear systems with output tracking error constraints are applied to the design of new tracking controllers for magnetic bearings. The proposed controllers can force the rotor to track a bounded and sufficiently smooth refer-ence trajectory asymptotically and guarantee non-contactedness be-tween the rotor and the stator of the magnetic bearings. Simulation results are included to illustrate the effectiveness of the proposed con-trollers.

  10. 77 FR 70423 - Black Bear Hydro Partners, LLC and Black Bear Development Holdings, LLC and Black Bear SO, LLC...

    Science.gov (United States)

    2012-11-26

    ... Energy Regulatory Commission Black Bear Hydro Partners, LLC and Black Bear Development Holdings, LLC and Black Bear SO, LLC; Notice of Application for Partial Transfer of Licenses, and Soliciting Comments and Motions To Intervene On October 25, 2012, Black Bear Hydro Partners, LLC, sole licensee (transferor)...

  11. An assessment of detection canine alerts using flowers that release methyl benzoate, the cocaine odorant, and an evaluation of their behavior in terms of the VOCs produced.

    Science.gov (United States)

    Cerreta, Michelle M; Furton, Kenneth G

    2015-06-01

    In recent years, the high frequency of illicit substance abuse reported in the United States has made the development of efficient and rapid detection methods important. Biological detectors, such as canines (Canis familiaris), are valuable tools for rapid, on-site identification of illicit substances. However, research indicates that in many cases canines do not alert to the contraband, but rather to the volatile organic compounds (VOCs) that are released from the contraband, referred to as the "active odor." In 2013, canine accuracy and reliability were challenged in the Supreme Court case, State of Florida v. Jardines. In this case, it was stated that if a canine alerts to the active odor, and not the contraband, the canine's accuracy and selectivity could be questioned, since many of these compounds have been found in common household products. Specifically, methyl benzoate, the active odor of cocaine, has been found to be the most abundant compound produced by snapdragon flowers. Therefore, the purpose of this study is to evaluate the odor profiles of various species of snapdragon flowers to assess how significantly methyl benzoate contributes to the total VOC profile or fragrance that is produced. Particularly, this study examines the VOCs released from newly grown snapdragon flowers and determines its potential at eliciting a false alert from specially trained detection canines. The ability of detection canines to differentiate between cocaine and snapdragon flowers was determined in order to validate the field accuracy and discrimination power of these detectors. An optimized method using headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME/GC-MS) was used to test the different types and abundances of compounds generated from snapdragon flowers at various stages throughout the plants' life cycle. The results indicate that although methyl benzoate is present in the odor profile of snapdragon flowers, other

  12. Tolerance and efficacy of emamectin benzoate and ivermectin for the treatment of Pseudocapillaria tomentosa in laboratory zebrafish (Danio rerio).

    Science.gov (United States)

    Collymore, Chereen; Watral, Virginia; White, Julie R; Colvin, Michael E; Rasmussen, Skye; Tolwani, Ravi J; Kent, Michael L

    2014-10-01

    Tolerance of adult zebrafish and efficacy of emamectin benzoate and ivermectin in eliminating Pseudocapillaria tomentosa infection were evaluated. In the tolerance study, behavioral changes, fecundity, histopathology, and mortality were evaluated for in-feed administration of emamectin (0.05, 0.10, and 0.25 mg/kg) and ivermectin (0.05 and 0.10 mg/kg). All doses of emamectin were well tolerated. Ivermectin 0.05 mg/kg administration resulted in mild behavioral changes and a transient decrease in fecundity. Ivermectin 0.10 mg/kg administration resulted in severe behavioral changes and some mortality. In the efficacy study, emamectin (0.05 and 0.25 mg/kg) and ivermectin (0.05 mg/kg) were evaluated for their efficacy in eliminating P. tomentosa infection. Emamectin reduced parasite burden in infected zebrafish, and ivermectin eliminated intestinal nematode infections. Despite a small margin of safety, ivermectin 0.05 mg/kg was effective at eliminating P. tomentosa infection in adult zebrafish. Higher doses or a longer course of treatment may be needed for complete elimination of P. tomentosa infection using emamectin. In this study, we propose two possible treatments for intestinal nematode infections in zebrafish.

  13. In vitro and in vivo metabolism of ethyl 4-[(2-hydroxy-1-naphthyl)azo]benzoate.

    Science.gov (United States)

    Bekce, Banu; Sener, Göksel; Oktav, Mehmet; Ulgen, Mert; Rollas, Sevim

    2005-01-01

    Azo compounds are extensively used for colouring food, drink, pharmaceuticals, cosmetics, textiles and printing inks. Publications in the literature have shown that azo dyes can pose threats to public health by metabolic and chemical oxidation and reduction reactions. In the present study, the in vivo and in vitro biotransformation of ethyl 4-[(2-hydroxy-1-naphthyl)azo]benzoate, an azo compound which is structurally similar to 1-phenylazo-2-naphthol was studied to investigate its in vivo and in vitro metabolic products. For the in vitro biotransformation study, rat liver microsomal preparations fortified with NADPH as a co-factor were used. Three unidentified metabolic products were observed. For the in vivo biotransformation study, a concentrated solution of this substrate was given orally to female rats. After the administration of substrate, blood samples of rats are taken at certain intervals. The blood plasma were obtained by centrifuging blood samples. The cold acetonitrile was added to plasma to precipitate plasma proteins and plasma was centrifuged. The supernatant was evaporated at room temperature. The residue was reconstituted with acetonitrile and examined by the HPLC. The unchanged substrate together with the corresponding reduction and acetylation products were detected in plasma. However, no initial hydrolysis occurred in the ester moiety.

  14. Synthesis, crystal structure, and fluorescence of two dimeric europium(Ⅲ) complexes with 2-(trifluoromethyl)benzoate

    Institute of Scientific and Technical Information of China (English)

    LI Yanqiu; LI Peizhou; LI Xia

    2008-01-01

    Two complexes [Eu2(2-TFMBA)6(2,2'-bipy)2].2H2O (1) and Eu2(2-TFMBA)6(1,10-phen)2 (2) (2-TFMBA=2-(Trifluoromethyl) benzoate; 2,2'-bipy=2,2'-bipyridine; 1,10-phen=1,10-phenanthroline) were synthesized by solvent method and determined by X-ray diffrac-tion analysis. Complex 1 crystallizes in monoclinic system with space group P21/c, whereas complex 2 crystallizes in triclinic system with space group P-1. Both are binuclear molecules with an inversion center. In complex 1, two center Eu3+ ions are linked together by four 2-TFMBA ligands in bidentate-bridging mode. Each Eu3+ion is eight-coordinated with six O atoms from five 2-TFMBA ligands and two N atoms from one 2,2'-bipy molecule. In complex 2, two center Eu3+ ions are linked together by four 2-TFMBA ligands in two modes, namely, bidentate-bridging and tridentate-bridging. Each Eu3+ ion is nine-coordinated with seven O atoms from five 2-TFMBA ligands and two N atoms from one 1,10-phen molecule. The two complexes both exhibited strong red fluorescence under ultraviolet light, and the 5D0→7Fj (j=0-4) transition emissions of Eu3+ ion were observed in their emission spectra.

  15. Application of Box-Behnken design to formulate and optimize multipolymeric fast dissolving film of rizatriptan benzoate

    Directory of Open Access Journals (Sweden)

    Dharmik M. Mehta

    2014-01-01

    Full Text Available The present investigation aims at formulation and optimization of multipolymeric fast dissolving film of rizatriptan benzoate. Three film forming polymers namely hydroxypropyl methylcellulose (HPMC, maltodextrin and polyvinylalcohol were explored using Box-Behnken experimental design to derive optimized fast dissolving film formulation using desirability function. Analysis of variance (ANOVA was performed for five dependent variables tensile strength, folding endurance, load at yield, percentage elongation and percentage drug release in 30 s (Q 30. Mathematical regression equations were derived by applying ANOVA and validated using checkpoint batches. Results of the experimental design exposed that the effect of independent factors HPMC and maltodextrin significantly influenced the mechanical properties and percentage drug release from the film. Optimized batch was derived based on set criteria using desirability function. Reponses of the optimized formulation were tensile strength (500 N/m 2, folding endurance (203, load at yield (15.06 N/m 2, percentage elongation (4.56% and Q 30 (60.03% falling under acceptable limits. High percentage drug release from the film in simulated saliva and simulated gastric fluid reveal fast dissolving characteristics. Fast dissolving dosage form can help patients with diseases like migraine.

  16. Analysis of citrates and benzoates used in poly(vinyl chloride) by supercritical fluid extraction and gas chromatography.

    Science.gov (United States)

    Guerra, R M; Marín, M L; Sánchez, A; Jiménez, A

    2002-03-15

    Supercritical fluid extraction (SFE) has been demonstrated to be a useful tool in the determination of additives in polymeric materials. This paper describes the determination of some citrates and benzoates in poly(vinyl chloride) blended with 33-34% of plasticizer using off-line SFE followed by gas chromatography. Experimental factors affecting SFE have been studied by gravimetric analysis, followed by analysis of the extracts using a gas chromatograph equipped with a flame ionization detector. The extraction process is governed by the solubility of the plasticizers in the supercritical fluid or by their diffusion through the polymer matrix, which depend on the pressure and temperature used. Maximum extraction (>99%) is obtained at pressures and temperatures higher than 40 MPa and 80 degrees C, respectively. Due to purge losses, the collection efficiency of plasticizers into a liquid solvent ranges from 85 to 90%. The applicability of the SFE method is demonstrated using real samples and comparing the results with those obtained by conventional Soxhlet extraction.

  17. Use of estradiol benzoate to induce ovulation in a short-term protocol for fixed-time AI in sheep

    Directory of Open Access Journals (Sweden)

    Caliê Castilho

    2015-06-01

    Full Text Available The aim of this study was to test the hormonal protocol for fixed-time artificial insemination (TAI with a progesterone vaginal device for six days applying equine chorionic gonadotropin (eCG or estradiol benzoate (EB as an ovulation inducer in ewes. On day 0 (D0, the ewes (n=31 received a device containing 0.33 g of intravaginal progesterone (CIDR® and were divided into three groups. The G-CT (control group used CIDR for nine days and upon withdrawal of the progesterone, were administered prostaglandin F2 alpha (PGF2? and eCG. In the eCG (G-eCG group, CIDR was administered for six days, instead of nine as in the G-CT group, followed by PGF2a and eCG after progesterone withdrawal. In the EB (G-EB group, CIDR was also administered for six days, but eCG was not applied, and EB was used to induce ovulation 24 hours after removing the CIDR and PGF2a application. TAI was realized in all groups 50 hours after CIDR withdrawal. The pregnancy rate in the G-eCG group (66% was higher (p 0.05 compared to the G-CT group (30%. It is possible to reduce the application time of the progesterone and use eCG for TAI in sheep; however, using EB resulted in a low ovulation rate in the sheep.

  18. Detection on emamectin benzoate-induced apoptosis and DNA damage in Spodoptera frugiperda Sf-9 cell line.

    Science.gov (United States)

    Wu, Xiwei; Zhang, Lei; Yang, Chao; Zong, Mimi; Huang, Qingchun; Tao, Liming

    2016-01-01

    Emamectin benzoate (EMB), an important macrocyclic lactone insecticide that belongs to the avermectin family and possesses excellent potency in controlling pests, is non-carcinogenic and non-mutagenic conducted in rats and mice, but EMB-induced cytotoxicity and genotoxicity in arthropod insect have been seldom reported yet. In the present paper, we quantified the cytotoxicity of EMB through the detections on cell viability, DNA damage, and cell apoptosis in Spodoptera frugiperda Sf-9 cells in vitro. The results showed that EMB caused a concentration- and time-dependent reduction on the viability of Sf-9 cells, and the median inhibitory concentrations (IC50) were 3.34μM at 72h of exposure. The dual acridine orange/ethidium bromide staining showed that exposure to EMB induced a significant time- and concentration-dependent increase on cell apoptosis. The alkaline comet assay revealed that EMB induced significant increases on single-strand DNA breaks, and the percentage of γH2AX-positive cells represented a time- and concentration-dependent formation of DNA double-strand breaks in Sf-9 cells. Interestingly, the similar cytotoxic actions of EMB also went for the human cancerous HeLa cells as a control cell group. Data demonstrated the potential cytotoxic effect of EMB on Sf-9 cells that was significantly greater than the effect of hydrogen peroxide at the same concentrations.

  19. Energetic domains and conformational analysis of human serum albumin upon co-incubation with sodium benzoate and glucose.

    Science.gov (United States)

    Taghavi, F; Moosavi-Movahedi, A A; Bohlooli, M; Habibi-Rezaei, M; Hadi Alijanvand, H; Amanlou, M; Sheibani, N; Saboury, A A; Ahmad, F

    2014-01-01

    Sodium benzoate (SB), a powerful inhibitor of microbial growth, is one of the most commonly used food preservative. Here, we determined the effects of SB on human serum albumin (HSA) structure in the presence or absence of glucose after 35 days of incubation under physiological conditions. The biochemical, biophysical, and molecular approaches including free amine content assay (TNBSA assay), fluorescence, and circular dichroism spectroscopy (CD), differential scanning calorimetry (DSC), and molecular docking and LIGPLOT studies were utilized for structural studies. The TNBSA results indicated that SB has the ability to bind Lys residues in HSA through covalent bonds. The docking and LIGPLOT studies also determined another specific site via hydrophobic interactions. The CD results showed more structural helicity for HSA incubated with SB, while HSA incubated with glucose had the least, and HSA incubated with glucose + SB had medium helicity. Fluorescence spectrophotometry results demonstrated partial unfolding of HSA incubated with SB in the presence or absence of glucose, while maximum partial unfolding was observed in HSA incubated with glucose. These results were confirmed by DSC and its deconvoluted thermograms. The DSC results also showed significant changes in HSA energetic structural domains due to HSA incubation with SB in the presence or absence of glucose. Together, our studies showed the formation of three different intermediates and indicate that biomolecular investigation are effective in providing new insight into safety determinations especially in health-related conditions including diabetes.

  20. Single and double hydrogen atom migrations in substituted alkyl benzoates: a study on the substituent effect using MIKE spectrometry

    Science.gov (United States)

    Tobita, Seiji; Tajima, Susumu; Ishihara, Yasuko; Kojima, Masahiro; Shigihara, Atsushi

    1994-03-01

    The substituent effect on the single and double hydrogen atom migrations is ionized ortho-, meta-, and para-substituted isobutyl (XC6H4COOC4H9) and isopropyl (XC6H4COOC3H7) benzoates is investigated by mass-analyzed ion kinetic energy spectrometry. The observed product ion ratios [XC6H4COOH]+/[XC6H4COOH2]+ show a general tendency: the compounds with an electron-donating substituent favour the formation of [XC6H4COOH]+ by single hydrogen atom migration (McLafferty rearrangement), while those with an electron-withdrawing substituent produce preferentially [XC6H4COOH2]+ through double hydrogen atom migration (McLaffery + 1 rearrangement). The thermochemical considerations combined with MO calculations show that the substituent effects observed are rationalized by the effects of substituent on the ionization energy (IE) and proton affinity (PA) of XC6H4COOH, i.e. the product ratios are determined by the difference of the product thermochemical stabilities which can be evaluated as IE(XC6H4COOH) + PA(XC6H4COOH).

  1. Characterization of Phenacoccus solenopsis (Tinsley) (Homoptera: Pseudococcidae) Resistance to Emamectin Benzoate: Cross-Resistance Patterns and Fitness Cost Analysis.

    Science.gov (United States)

    Afzal, M B S; Shad, S A

    2016-06-01

    Cotton mealybug Phenacoccus solenopsis (Tinsley) (Homoptera: Pseudococcidae) is a sucking pest of worldwide importance causing huge losses by feeding upon cotton in various parts of the world. Because of the importance of this pest, this research was carried out to select emamectin resistance in P. solenopsis in the laboratory to study cross-resistance, stability, realized heritability, and fitness cost of emamectin resistance. After selection from third generation (G3) to G6, P. solenopsis developed very high emamectin resistance (159.24-fold) when compared to a susceptible unselected population (Unsel pop). Population selected to emamectin benzoate conferred moderate (45.81-fold), low (14.06-fold), and no cross-resistance with abamectin, cypermethrin, and profenofos, respectively compared to the Unsel pop. A significant decline in emamectin resistance was observed in the resistant population when not exposed to emamectin from G7 to G13. The estimated realized heritability (h (2)) for emamectin resistance was 0.84. A high fitness cost was associated with emamectin resistance in P. solenopsis. Results of this study may be helpful in devising insecticide resistance management strategies for P. solenopsis.

  2. Simplified RP-HPLC method for multi-residue analysis of abamectin, emamectin benzoate and ivermectin in rice.

    Science.gov (United States)

    Xie, Xianchuan; Gong, Shu; Wang, Xiaorong; Wu, Yinxing; Zhao, Li

    2011-01-01

    A rapid, reliable and sensitive reverse-phase high-performance liquid chromatography method with fluorescence detection (RP-FLD-HPLC) was developed and validated for simultaneous analysis of the abamectin (ABA), emamectin (EMA) benzoate and ivermectin (IVM) residues in rice. After extraction with acetonitrile/water (2 : 1) with sonication, the avermectin (AVMs) residues were directly derivatised by N-methylimidazole (N-NMIM) and trifluoroacetic anhydride (TFAA) and then analysed on RP-FLD-HPLC. A good linear relationship (r(2 )> 0.99) was obtained for three AVMs ranging from 0.01 to 5 microg ml(-1), i.e. 0.01-5.0 microg g(-1) in rice matrix. The limit of detection (LOD) and the limit of quantification (LOQ) were between 0.001 and 0.002 microg g(-1) and between 0.004 and 0.006 microg g(-1), respectively. Recoveries were from 81.9% to 105.4% and precision less than 12.4%. The proposed method was successfully applied to routine analysis of the AVMs residues in rice.

  3. Synthesis and Biological Evaluation of 2-Hydroxy-3-[(2-aryloxyethylamino]propyl 4-[(Alkoxycarbonylamino]benzoates

    Directory of Open Access Journals (Sweden)

    Jan Tengler

    2013-01-01

    Full Text Available A series of twenty substituted 2-hydroxy-3-[(2-aryloxyethylamino]propyl 4-[(alkoxycarbonylamino]benzoates were prepared and characterized. As similar compounds have been described as potential antimycobacterials, primary in vitro screening of the synthesized carbamates was also performed against two mycobacterial species. 2-Hydroxy-3-[2-(2,6-dimethoxyphenoxyethylamino]-propyl 4-(butoxycarbonylaminobenzoate hydrochloride, 2-hydroxy-3-[2-(4-methoxyphenoxyethylamino]-propyl 4-(butoxycarbonylaminobenzoate hydrochloride, and 2-hydroxy-3-[2-(2-methoxyphenoxyethylamino]-propyl 4-(butoxycarbonylaminobenzoate hydrochloride showed higher activity against M. avium subsp. paratuberculosis and M. intracellulare than the standards ciprofloxacin, isoniazid, or pyrazinamide. Cytotoxicity assay of effective compounds was performed using the human monocytic leukaemia THP-1 cell line. Compounds with predicted amphiphilic properties were also tested for their effects on the rate of photosynthetic electron transport (PET in spinach (Spinacia oleracea L. chloroplasts. All butyl derivatives significantly stimulated the rate of PET, indicating that the compounds can induce conformational changes in thylakoid membranes resulting in an increase of their permeability and so causing uncoupling of phosphorylation from electron transport.

  4. Vibrational spectroscopy, intramolecular CH⋯O interaction and conformational analysis of 2,5-dimethyl-benzyl benzoate

    Science.gov (United States)

    Viana, Rommel B.; Ribeiro, Gabriela L. O.; Valencia, Leidy J.; Varela, Jaldyr J. G.; Viana, Anderson B.; da Silva, Albérico B. F.; Moreno-Fuquen, Rodolfo

    2016-12-01

    The aim of this study was to report the spectroscopic and electronic properties of 2,5-dimethyl-benzyl benzoate. FT-IR and Raman vibrational spectral analyses were performed, while a computational approach was used to elucidate the vibrational frequency couplings. The electronic properties were predicted using the Density Functional Theory, while the G3MP2 method was employed in the thermochemical calculation. A conformational analysis, frontier orbitals, partial atomic charge distribution and the molecular electrostatic potential were also estimated. Concerning to the dihedral angles in the ester group, a conformational analysis showed a barrier energy of 10 kcal mol-1, while other small barriers (below 0.6 kcal mol-1) were predicted within the potential surface energy investigation. Insights into the relative stability among the different positions of methyl groups in the phenyl ring demonstrated that the energy gaps were lower than 1 kcal mol-1 among the regioisomers. In addition, the Quantum Theory of Atoms in Molecules (QTAIM) was used to understand the intramolecular CH⋯O interaction in the title compound, while various methodologies were applied in the atomic charge distribution to evaluate the susceptibility to the population method.

  5. DNA content alterations in Tetrahymena pyriformis macronucleus after exposure to food preservatives sodium nitrate and sodium benzoate.

    Science.gov (United States)

    Loutsidou, Ariadni C; Hatzi, Vasiliki I; Chasapis, C T; Terzoudi, Georgia I; Spiliopoulou, Chara A; Stefanidou, Maria E

    2012-12-01

    The toxicity, in terms of changes in the DNA content, of two food preservatives, sodium nitrate and sodium benzoate was studied on the protozoan Tetrahymena pyriformis using DNA image analysis technology. For this purpose, selected doses of both food additives were administered for 2 h to protozoa cultures and DNA image analysis of T. pyriformis nuclei was performed. The analysis was based on the measurement of the Mean Optical Density which represents the cellular DNA content. The results have shown that after exposure of the protozoan cultures to doses equivalent to ADI, a statistically significant increase in the macronuclear DNA content compared to the unexposed control samples was observed. The observed increase in the macronuclear DNA content is indicative of the stimulation of the mitotic process and the observed increase in MOD, accompanied by a stimulation of the protozoan proliferation activity is in consistence with this assumption. Since alterations at the DNA level such as DNA content and uncontrolled mitogenic stimulation have been linked with chemical carcinogenesis, the results of the present study add information on the toxicogenomic profile of the selected chemicals and may potentially lead to reconsideration of the excessive use of nitrates aiming to protect public health.

  6. Superconductor bearings, flywheels and transportation

    Science.gov (United States)

    Werfel, F. N.; Floegel-Delor, U.; Rothfeld, R.; Riedel, T.; Goebel, B.; Wippich, D.; Schirrmeister, P.

    2012-01-01

    This paper describes the present status of high temperature superconductors (HTS) and of bulk superconducting magnet devices, their use in bearings, in flywheel energy storage systems (FESS) and linear transport magnetic levitation (Maglev) systems. We report and review the concepts of multi-seeded REBCO bulk superconductor fabrication. The multi-grain bulks increase the averaged trapped magnetic flux density up to 40% compared to single-grain assembly in large-scale applications. HTS magnetic bearings with permanent magnet (PM) excitation were studied and scaled up to maximum forces of 10 kN axially and 4.5 kN radially. We examine the technology of the high-gradient magnetic bearing concept and verify it experimentally. A large HTS bearing is tested for stabilizing a 600 kg rotor of a 5 kWh/250 kW flywheel system. The flywheel rotor tests show the requirement for additional damping. Our compact flywheel system is compared with similar HTS-FESS projects. A small-scale compact YBCO bearing with in situ Stirling cryocooler is constructed and investigated for mobile applications. Next we show a successfully developed modular linear Maglev system for magnetic train operation. Each module levitates 0.25t at 10 mm distance during one-day operation without refilling LN2. More than 30 vacuum cryostats containing multi-seeded YBCO blocks are fabricated and are tested now in Germany, China and Brazil.

  7. Magnetic bearings with zero bias

    Science.gov (United States)

    Brown, Gerald V.; Grodsinsky, Carlos M.

    1991-01-01

    A magnetic bearing operating without a bias field has supported a shaft rotating at speeds up to 12,000 rpm with the usual four power supplies and with only two. A magnetic bearing is commonly operated with a bias current equal to half of the maximum current allowable in its coils. This linearizes the relation between net force and control current and improves the force slewing rate and hence the band width. The steady bias current dissipates power, even when no force is required from the bearing. The power wasted is equal to two-thirds of the power at maximum force output. Examined here is the zero bias idea. The advantages and disadvantages are noted.

  8. Safety and determination benzoic acid and sodium benzoate%苯甲酸和苯甲酸钠安全性与检测方法研究进展

    Institute of Scientific and Technical Information of China (English)

    李菊; 刘淑君; 黄雪琳

    2012-01-01

      As one of the acidic preservative,the abuse of benzoic acid and sodium benzoate is very dangerous. Because the residue of benzoic acid and sodium benzoate would do great harm to the human health even cause cancer after they were taken through the food and medicament. The researchers have dedicated many efforts to research for residue determination of benzoic acid and Sodium Benzoate. The security and methods for benzoic acid and sodium benzoate detection were summarized. this study was useful for the detecting technology of benzoic acid and sodium benzoate residues.%  苯甲酸和苯甲酸钠是一种酸性防腐剂,过量滥用很危险;因苯甲酸和苯甲酸钠被人体过量摄入后,会对人体健康造成极大危害,甚至致癌。该文对苯甲酸和苯甲酸钠残留安全性及检测方法进行综述,以期为苯甲酸和苯甲酸钠残留检测方法研究提供参考。

  9. Sensitive and selective methods for the determination of rizatriptan benzoate in pharmaceuticals using N-bromosuccinimide and two dyes

    Directory of Open Access Journals (Sweden)

    Kudige Nagaraj Prashanth

    2015-05-01

    Full Text Available One titrimetric and two spectrophotometric methods are described for the determination of rizatriptan benzoate (RTB in bulk drugs and in tablets. The methods use N-bromosuccinimide (NBS as an analytical reagent, janus green (JG and calmagite (CMG as auxiliary reagents. All the three methods are indirect in which the unreacted NBS is determined after the reaction between RTB and NBS is judged complete by iodometric back titration (method A or by reacting with a fixed amount of either janus green (method B or calmagite (method C followed by the measurement of absorbance at 620 nm (method B or 540 nm (method C. Titrimetry allows the determination of 1–10 mg of RTB and follows a reaction stoichiometry of 1:3 (RTB:NBS, whereas spectrophotometric methods are applicable over the concentration ranges of 0.5–8.0 μg ml−1 in method B and 1.5–30.0 μg ml−1 in method C. Method B with a calculated molar absorptivity of 3.03 × 104 L mol−1 cm−1 is the second most sensitive spectrophotometric method ever developed for RTB. The quality control/assurance parameters such as limits of detection (LOD, quantification (LOQ and Sandelle’s sensitivity values are also reported for the spectrophotometric method. The accuracy and precision of the methods were studied on intra-day and inter-day basis. No interference was observed from common pharmaceutical adjuvants. Statistical comparison of the results with a reference method showed excellent agreement, and indicates no significant difference in accuracy and precision. The reliability of the methods was further ascertained by recovery studies via standard addition procedures.

  10. Up-regulation of neurotrophic factors by cinnamon and its metabolite sodium benzoate: therapeutic implications for neurodegenerative disorders.

    Science.gov (United States)

    Jana, Arundhati; Modi, Khushbu K; Roy, Avik; Anderson, John A; van Breemen, Richard B; Pahan, Kalipada

    2013-06-01

    This study underlines the importance of cinnamon, a widely-used food spice and flavoring material, and its metabolite sodium benzoate (NaB), a widely-used food preservative and a FDA-approved drug against urea cycle disorders in humans, in increasing the levels of neurotrophic factors [e.g., brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3)] in the CNS. NaB, but not sodium formate (NaFO), dose-dependently induced the expression of BDNF and NT-3 in primary human neurons and astrocytes. Interestingly, oral administration of ground cinnamon increased the level of NaB in serum and brain and upregulated the levels of these neurotrophic factors in vivo in mouse CNS. Accordingly, oral feeding of NaB, but not NaFO, also increased the level of these neurotrophic factors in vivo in the CNS of mice. NaB induced the activation of protein kinase A (PKA), but not protein kinase C (PKC), and H-89, an inhibitor of PKA, abrogated NaB-induced increase in neurotrophic factors. Furthermore, activation of cAMP response element binding (CREB) protein, but not NF-κB, by NaB, abrogation of NaB-induced expression of neurotrophic factors by siRNA knockdown of CREB and the recruitment of CREB and CREB-binding protein to the BDNF promoter by NaB suggest that NaB exerts its neurotrophic effect through the activation of CREB. Accordingly, cinnamon feeding also increased the activity of PKA and the level of phospho-CREB in vivo in the CNS. These results highlight a novel neutrophic property of cinnamon and its metabolite NaB via PKA - CREB pathway, which may be of benefit for various neurodegenerative disorders.

  11. DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk

    Science.gov (United States)

    Cheong, Ana; Zhang, Xiang; Cheung, Yuk-Yin; Tang, Wan-yee; Chen, Jing; Ye, Shu-Hua; Medvedovic, Mario; Leung, Yuet-Kin; Prins, Gail S.; Ho, Shuk-Mei

    2016-01-01

    ABSTRACT Developmental exposure to endocrine-disrupting chemicals (EDCs), 17β-estradiol-3-benzoate (EB) and bisphenol A (BPA), increases susceptibility to prostate cancer (PCa) in rodent models. Here, we used the methylated-CpG island recovery assay (MIRA)-assisted genomic tiling and CpG island arrays to identify treatment-associated methylome changes in the postnatal day (PND)90 dorsal prostate tissues of Sprague-Dawley rats neonatally (PND1, 3, and 5) treated with 25 µg/pup or 2,500 µg EB/kg body weight (BW) or 0.1 µg BPA/pup or 10 µg BPA/kg BW. We identified 111 EB-associated and 86 BPA-associated genes, with 20 in common, that have significant differentially methylated regions. Pathway analysis revealed cancer as the top common disease pathway. Bisulfite sequencing validated the differential methylation patterns observed by array analysis in 15 identified candidate genes. The methylation status of 7 (Pitx3, Wnt10b, Paqr4, Sox2, Chst14, Tpd52, Creb3l4) of these 15 genes exhibited an inverse correlation with gene expression in tissue samples. Cell-based assays, using 5-aza-cytidine-treated normal (NbE-1) and cancerous (AIT) rat prostate cells, added evidence of DNA methylation-mediated gene expression of 6 genes (exception: Paqr4). Functional connectivity of these genes was linked to embryonic stem cell pluripotency. Furthermore, clustering analyses using the dataset from The Cancer Genome Atlas revealed that expression of this set of 7 genes was associated with recurrence-free survival of PCa patients. In conclusion, our study reveals that gene-specific promoter methylation changes, resulting from early-life EDC exposure in the rat, may serve as predictive epigenetic biomarkers of PCa recurrence, and raises the possibility that such exposure may impact human disease. PMID:27415467

  12. Sodium benzoate, a food preservative, affects the functional and activation status of splenocytes at non cytotoxic dose.

    Science.gov (United States)

    Yadav, Ashish; Kumar, Arvind; Das, Mukul; Tripathi, Anurag

    2016-02-01

    Sodium benzoate (SB) is a widely used food preservative due to its bacteriostatic and fungistatic properties. The acceptable daily intake of SB is 5 mg/kg-bw, however, it has been found to be used in the food commodities at relatively high levels (2119 mg/kg). Earlier studies on SB have shown its immunosuppressive properties, but comprehensive immunotoxicity data is lacking. Our studies have shown that SB was non cytotoxic in splenocytes up to 1000 μg/ml for 72 h, however at 2500 μg/ml it was found to be cytotoxic. Thus, 1000 μg/ml dose of SB was chosen for the subsequent experiments. SB significantly suppresses the proliferation of Con A and LPS stimulated splenocytes at 72 h, while allogenic response of T cells was significantly decreased after 96 h. SB did not affect the relative expression of CD3e or CD4 molecules following 72 h exposure, however, it downregulated the relative expression of CD8 co-receptor. Further, exposure of splenocytes to SB for 72 h led to reduced expression of CD28 and CD95, which play a vital role in T cell activation. SB also suppresses the relative expression of CD19, CD40 and CD95 receptors on B cells after 72 h. In addition to the functional responses, SB lowered the expression of IL4, IL6, IFNγ and IL17 cytokines in Con A stimulated splenocytes; and IL6, IFNγ and TNFα in LPS stimulated splenocytes following 48 h of exposure. Taken together, the present study is suggestive of the immunomodulatory potential of SB.

  13. Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates ciliary neurotrophic factor in astrocytes and oligodendrocytes

    Science.gov (United States)

    Modi, Khushbu K.; Jana, Malabendu; Mondal, Susanta; Pahan, Kalipada

    2015-01-01

    Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor that plays an important role in multiple sclerosis (MS). However, mechanisms by which CNTF expression could be increased in the brain are poorly understood. Recently we have discovered anti-inflammatory and immunomodulatory activities of sodium benzoate (NaB), a metabolite of cinnamon and a widely-used food additive. Here, we delineate that NaB is also capable of increasing the mRNA and protein expression of CNTF in primary mouse astrocytes and oligodendrocytes and primary human astrocytes. Accordingly, oral administration of NaB and cinnamon led to the upregulation of astroglial and oligodendroglial CNTF in vivo in mouse brain. Induction of experimental allergic encephalomyelitis (EAE), an animal model of MS, reduced the level of CNTF in the brain, which was restored by oral administration of cinnamon. While investigating underlying mechanisms, we observed that NaB induced the activation of protein kinase A (PKA) and H-89, an inhibitor of PKA, abrogated NaB-induced expression of CNTF. The activation of cAMP response element binding (CREB) protein by NaB, the recruitment of CREB and CREB-binding protein to the CNTF promoter by NaB and the abrogation of NaB-induced expression of CNTF in astrocytes by siRNA knockdown of CREB suggest that NaB increases the expression of CNTF via the activation of CREB. These results highlight a novel myelinogenic property of NaB and cinnamon, which may be of benefit for MS and other demyelinating disorders. PMID:26399250

  14. EFFECT OF SODIUM BENZOATE ON THE QUALITY AND SENSORY PROPERTIES OF KUNUN-ZAKI SUPPLEMENTED WITH GROUNDNUT

    Directory of Open Access Journals (Sweden)

    Taiwo Aderinola

    2014-04-01

    Full Text Available The quality parameters of kunu-zaki supplemented with groundnut was investigated in this study. Millet, groundnut, ginger, dry red pepper and sugar were used for the production. After production, some samples were pasteurized at 700C for 30 minutes and stored at refrigerated (oC and ambient conditions (oC. A fresh control sample was also prepared at interval for comparison. Analyses were carried out to determine the chemical composition, microbiological and sensory qualities of product during storage over a period of twenty seven (27 days. Results showed that addition of groundnut improved chemical composition of the fresh samples. It could be attributed to the crude protein and the fat content in the added groundnut. The results were: moisture, 75.7%; crude protein, 13.06%; fat, 7.35%; ash, 0.39% and carbohydrate, 3.5%. The pH values for the fresh samples were: 3.31 (pasteurized refrigerated; 3.31 (pasteurized unrefrigerated; 3.57 (unpasteurized refrigerated; 3.64 (unpasteurized unrefrigerated and 3.93 for the Fresh sample. The results of the mineral element (mg/100g were: Ca, 152; Na, 0.19; Mg, 4.76; K, 2.74 and P, 123.22. There was no detection of the presence of the indicator organism – E coli. Results of the sensory evaluation of the product carried out using a five-man panel showed that there were no differences in the appearance, taste and flavor for the first day. However, the pasteurized refrigerated sample with the addition of sodium benzoate was better on the overall acceptability.

  15. 超声法制备苯甲酸钠微胶囊的工艺研究%Research on Processing Technology of Sodium Benzoate Microcapsules by Ultrasound

    Institute of Scientific and Technical Information of China (English)

    章斌; 刘志聪; 侯小桢; 赖宣; 许淼鑫; 王士超

    2014-01-01

    以β-环糊精为壁材,以包埋率为指标,采用单因素试验和Box-Behnken 中心组合设计试验对超声法制备苯甲酸钠微胶囊的工艺进行优化。试验结果表明:超声法制备苯甲酸钠包合物的最佳工艺条件为芯/壁材比1∶7.17,超声包埋时间29.9 min,超声包埋功率180 W,此条件下的实际包埋率为80.5%,与模型预测值之间具有较好的拟合性。%Takeβ-cyclodextrin as wall material and embedding rate of sodium benzoate as main index, the single factor experiment and Box-Behnken response surface methodology for optimization of sodi-um benzoate microcapsules by ultrasound method is explored.The results show that the optimum process conditions for preparation of sodium benzoate clathrate by ultrasound method are as follows:the core/wall material ratio of 1∶7.17,the ultrasonic embedding time of 29.9 min,the ultrasonic embedding power of 180 W,the embedding rate can reach 80.5%,and the regression model is con-sistent with the predicted results.

  16. The correct "ball bearings" data.

    Science.gov (United States)

    Caroni, C

    2002-12-01

    The famous data on fatigue failure times of ball bearings have been quoted incorrectly from Lieblein and Zelen's original paper. The correct data include censored values, as well as non-fatigue failures that must be handled appropriately. They could be described by a mixture of Weibull distributions, corresponding to different modes of failure.

  17. Losses of Superconductor Journal Bearing

    Science.gov (United States)

    Han, Y. H.; Hull, J. R.; Han, S. C.; Jeong, N. H.; Oh, J. M.; Sung, T. H.

    2004-06-01

    A high-temperature superconductor (HTS) journal bearing was studied for rotational loss. Two HTS bearings support the rotor at top and bottom. The rotor weight is 4 kg and the length is about 300 mm. Both the top and bottom bearings have two permanent magnet (PM) rings with an iron pole piece separating them. Each HTS journal bearing is composed of six pieces of superconductor blocks of size 35×25×10 mm. The HTS blocks are encased in a cryochamber through which liquid nitrogen flows. The inner spool of the cryochamber is made from G-10 to reduce eddy current loss, and the rest of the cryochamber is stainless steel. The magnetic field from the PM rings is < 10 mT on the stainless part. The rotational drag was measured over the same speed range at several chamber pressures. Results indicate that a chamber pressure of 0.4 mtorr is sufficiently low to minimize windage loss, and the 10 mT design criterion for the magnetic field on the stainless part of the cryochamber is too high.

  18. Characterization of Fault Size in Bearings

    Science.gov (United States)

    2014-12-23

    0.3 and 1.2 mm into the outer-race of the bearing, which simulates realistic faults that often can be found in damaged bearings. A 3D dynamic model ...3 4. MODEL DESCRIPTION A 3D dynamic ball bearing model was developed to study the effect of faults on the bearing dynamic behavior. The aim of the...understanding of the effects of fault size on the bearing dynamics. The research methodology combines dynamic modeling of the faulty bearing with

  19. Transcription analysis of stx1, marA, and eaeA genes in Escherichia coli O157:H7 treated with sodium benzoate.

    Science.gov (United States)

    Critzer, Faith J; Dsouza, Doris H; Golden, David A

    2008-07-01

    Expression of the multiple antibiotic resistance (mar) operon causes increased antimicrobial resistance in bacterial pathogens. The activator of this operon, MarA, can alter expression of >60 genes in Escherichia coli K-12. However, data on the expression of virulence and resistance genes when foodborne pathogens are exposed to antimicrobial agents are lacking. This study was conducted to determine transcription of marA (mar activator), stx1 (Shiga toxin 1), and eaeA (intimin) genes of E. coli O157:H7 EDL933 as affected by sodium benzoate. E. coli O157:H7 was grown in Luria-Bertani broth containing 0 (control) and 1% sodium benzoate at 37 degrees C for 24 h, and total RNA was extracted. Primers were designed for hemX (209 bp; housekeeping gene), marA (261 bp), and eaeA (223 bp) genes; previously reported primers were used for stx1. Tenfold dilutions of RNA were used in a real-time one-step reverse transcriptase PCR to determine transcription levels. All experiments were conducted in triplicate, and product detection was validated by gel electrophoresis. For marA and stx1, real-time one-step reverse transcriptase PCR products were detected at a 1-log-greater dilution in sodium benzoate-treated cells than in control cells, although cell numbers for each were similar (7.28 and 7.57 log CFU/ml, respectively). This indicates a greater (albeit slight) level of their transcription in treated cells than in control cells. No difference in expression of eaeA was observed. HemX is a putative uroporphyrinogen III methylase. The hemX gene was expressed at the same level in control and treated cells, validating hemX as an appropriate housekeeping marker. These data indicate that stx1 and marA genes could play a role in pathogen virulence and survival when treated with sodium benzoate, whereas eaeA expression is not altered. Understanding adaptations of E. coli O157:H7 during antimicrobial exposure is essential to better understand and implement methods to inhibit or control

  20. Practical synthesis of methyl (E)-2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate, a key intermediate of Montelukast

    Institute of Scientific and Technical Information of China (English)

    Liang He; Yang Hui Guo; Ya Ping Wang; Xiang Jing Wang; Ji Zhang; Wen Sheng Xiang

    2012-01-01

    A novel and practical synthetic route is presented for the preparation of methyl-(E)-2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate,the key intermediate of Montelukast,a leukotriene antagonist.The main diarylpropane framework was prepared via a polarity conversation reaction resulting in an acyl anion equivalent followed by a nucleophilic substitution reaction.The overall yield of this approach was 61%.This method is simple for operation and suitable for industrial production.

  1. The reproductive performance of dairy cows with anovulatory anoestrus that were injected with either gonadotrophin-releasing hormone or oestradiol benzoate as part of a re-treatment process after insemination

    Directory of Open Access Journals (Sweden)

    B.V.E. Segwagwe

    2007-05-01

    Full Text Available This experiment compared the reproductive performance of synchronised anoestrous dairy cows that were treated initially with a combination of progesterone and oestradiol benzoate and then with either gonadotrophin-releasing hormone (GnRH or oestradiol benzoate to resynchronise returns to service. It was hypothesised that injecting anoestrous dairy cows with GnRH 12-15 days after insemination and coinciding with the time of insertion of a controlled intravaginal progesterone-releasing (CIDR device would increase conception rates to the preceding 1st insemination compared with oestradiol benzoate treated cows; both GnRH and oestradiol benzoate would resynchronising the returns to service of those cows that did not conceive to the preceding insemination. Groups of cows in 11 herds were presented for a veterinary examination after they had not been seen in oestrus postpartum. Those cows diagnosed with anovulatory anoestrus (n = 1112 by manual rectal palpation and / or ultrasonography were enrolled in the trial. Each enrolled cow was injected with 2mg oestradiol benzoate i.m. on Day -10, (where Day 0 was the 1st day of the planned insemination concurrently with vaginal insertion of a CIDR device. The device inserted was withdrawn on Day -2 and then each cow injected i.m. with 1 mg of oestradiol benzoate on Day -1 unless it was in oestrus. Observation for oestrus preceded each insemination. Every cow that had been inseminated on Days -1,0,1 or 2 was presented for treatment for resynchrony on Day 14 (n=891. They were divided into 2 groups; those with an even number were each injected i.m. with 250 µg of a GnRH agonist (Treatment group n = 477; each of the cows with an odd number injected i.m. with 1mg of oestradiol benzoate (control group, n = 414. Each GnRH or oestradiol benzoate injection preceded reinsertion of a CIDR device previously inserted from Days -10 to -2. It was withdrawn on Day 22, 24 hours before injecting 1mg oestradiol benzoate

  2. Journal and Wave Bearing Impedance Calculation Software

    Science.gov (United States)

    Hanford, Amanda; Campbell, Robert

    2012-01-01

    The wave bearing software suite is a MALTA application that computes bearing properties for user-specified wave bearing conditions, as well as plain journal bearings. Wave bearings are fluid film journal bearings with multi-lobed wave patterns around the circumference of the bearing surface. In this software suite, the dynamic coefficients are outputted in a way for easy implementation in a finite element model used in rotor dynamics analysis. The software has a graphical user interface (GUI) for inputting bearing geometry parameters, and uses MATLAB s structure interface for ease of interpreting data. This innovation was developed to provide the stiffness and damping components of wave bearing impedances. The computational method for computing bearing coefficients was originally designed for plain journal bearings and tilting pad bearings. Modifications to include a wave bearing profile consisted of changing the film thickness profile given by an equation, and writing an algorithm to locate the integration limits for each fluid region. Careful consideration was needed to implement the correct integration limits while computing the dynamic coefficients, depending on the form of the input/output variables specified in the algorithm.

  3. Brown bear telemetry and trapping: Special report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Brown bear studies were continued during the 1967 field season with emphasis on development of techniques for instrumenting bears with radio transmitters and...

  4. Live-trapping and handling brown bear

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This paper reports techniques developed to live trap and handle brown bears on the Kodiak National Wildlife Refuge. The brown bears (Ursus middendorffi) on the...

  5. Rolling Element Bearing Stiffness Matrix Determination (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Y.; Parker, R.

    2014-01-01

    Current theoretical bearing models differ in their stiffness estimates because of different model assumptions. In this study, a finite element/contact mechanics model is developed for rolling element bearings with the focus of obtaining accurate bearing stiffness for a wide range of bearing types and parameters. A combined surface integral and finite element method is used to solve for the contact mechanics between the rolling elements and races. This model captures the time-dependent characteristics of the bearing contact due to the orbital motion of the rolling elements. A numerical method is developed to determine the full bearing stiffness matrix corresponding to two radial, one axial, and two angular coordinates; the rotation about the shaft axis is free by design. This proposed stiffness determination method is validated against experiments in the literature and compared to existing analytical models and widely used advanced computational methods. The fully-populated stiffness matrix demonstrates the coupling between bearing radial, axial, and tilting bearing deflections.

  6. Goose Eggs Could Save Polar Bears

    Institute of Scientific and Technical Information of China (English)

    孙淑敏

    2009-01-01

    Polar bears could avoid extinction despitemany starving to death in coming years, ac-cording to scientists and other observers whohave discovered that some of the bears havefound a new food source--goose and duckeggs.

  7. Stable isotopes to detect food-conditioned bears and to evaluate human-bear management

    Science.gov (United States)

    Hopkins, John B.; Koch, Paul L.; Schwartz, Charles C.; Ferguson, Jake M.; Greenleaf, Schuyler S.; Kalinowski, Steven T.

    2012-01-01

    We used genetic and stable isotope analysis of hair from free-ranging black bears (Ursus americanus) in Yosemite National Park, California, USA to: 1) identify bears that consume human food, 2) estimate the diets of these bears, and 3) evaluate the Yosemite human–bear management program. Specifically, we analyzed the isotopic composition of hair from bears known a priori to be food-conditioned or non-food-conditioned and used these data to predict whether bears with an unknown management status were food-conditioned (FC) or non-food-conditioned (NFC). We used a stable isotope mixing model to estimate the proportional contribution of natural foods (plants and animals) versus human food in the diets of FC bears. We then used results from both analyses to evaluate proactive (population-level) and reactive (individual-level) human–bear management, and discussed new metrics to evaluate the overall human–bear management program in Yosemite. Our results indicated that 19 out of 145 (13%) unknown bears sampled from 2005 to 2007 were food-conditioned. The proportion of human food in the diets of known FC bears likely declined from 2001–2003 to 2005–2007, suggesting proactive management was successful in reducing the amount of human food available to bears. In contrast, reactive management was not successful in changing the management status of known FC bears to NFC bears, or in reducing the contribution of human food to the diets of FC bears. Nine known FC bears were recaptured on 14 occasions from 2001 to 2007; all bears were classified as FC during subsequent recaptures, and human–bear management did not reduce the amount of human food in the diets of FC bears. Based on our results, we suggest Yosemite continue implementing proactive human–bear management, reevaluate reactive management, and consider removing problem bears (those involved in repeated bear incidents) from the population.

  8. Grease lubrication mechanisms in bearing seals

    OpenAIRE

    2011-01-01

    Rolling bearings contain seals to keep lubricant inside and contaminants outside the bearing system. These systems are often lubricated with grease; the grease acts as a lubricant for the bearing and seal and improves the sealing efficiency. In this thesis, the influence of lubricating grease on bearing seal performance is studied. Rheological properties of the grease, i.e. shear stress and normal stress difference, are evaluated and related to the lubricating and sealing performance of the s...

  9. Effects of estradiol benzoate on 5'-iodothyronine deiodinase activities in female rat anterior pituitary gland, liver and thyroid gland

    Directory of Open Access Journals (Sweden)

    Lisbôa P.C.

    1997-01-01

    Full Text Available There is little information on the possible effects of estrogen on the activity of 5'-deiodinase (5'-ID, an enzyme responsible for the generation of T3, the biologically active thyroid hormone. In the present study, anterior pituitary sonicates or hepatic and thyroid microsomes from ovariectomized (OVX rats treated or not with estradiol benzoate (EB, 0.7 or 14 µg/100 g body weight, sc, for 10 days were assayed for type I 5'-ID (5'-ID-I and type II 5'-ID (5'-ID-II, only in pituitary activities. The 5'-ID activity was evaluated by the release of 125I from deiodinated 125I rT3, using specific assay conditions for type I or type II. Serum TSH and free T3 and free T4 were measured by radioimmunoassay. OVX alone induced a reduction in pituitary 5'-ID-I (control = 723.7 ± 67.9 vs OVX = 413.9 ± 26.9; P<0.05, while the EB-treated OVX group showed activity similar to that of the normal group. Thyroid 5'-ID-I showed the same pattern of changes, but these changes were not statistically significant. Pituitary and hepatic 5'-ID-II did not show major alterations. The treatment with the higher EB dose (14 µg, contrary to the results obtained with the lower dose, had no effect on the reduced pituitary 5'-ID-I of OVX rats. However, it induced an important increment of 5'-ID-I in the thyroid gland (0.8 times higher than that of the normal group: control = 131.9 ± 23.7 vs ovx + EB 14 µg = 248.0 ± 31.2; P<0.05, which is associated with increased serum TSH (0.6-fold vs OVX, P<0.05 but normal serum free T3 and free T4. The data suggest that estrogen is a physiological stimulator of anterior pituitary 5'-ID-I and a potent stimulator of the thyroid enzyme when employed at high doses

  10. Thin film superconductor magnetic bearings

    Science.gov (United States)

    Weinberger, Bernard R.

    1995-12-26

    A superconductor magnetic bearing includes a shaft (10) that is subject to a load (L) and rotatable around an axis of rotation, a magnet (12) mounted to the shaft, and a stator (14) in proximity to the shaft. The stator (14) has a superconductor thin film assembly (16) positioned to interact with the magnet (12) to produce a levitation force on the shaft (10) that supports the load (L). The thin film assembly (16) includes at least two superconductor thin films (18) and at least one substrate (20). Each thin film (18) is positioned on a substrate (20) and all the thin films are positioned such that an applied magnetic field from the magnet (12) passes through all the thin films. A similar bearing in which the thin film assembly (16) is mounted on the shaft (10) and the magnet (12) is part of the stator (14) also can be constructed.

  11. Cryptosporidiosis in a black bear in Virginia.

    Science.gov (United States)

    Duncan, R B; Caudell, D; Lindsay, D S; Moll, H D

    1999-04-01

    Cryptosporidiosis has not been previously reported in black bears in North America, either free-roaming or captive. However, oocysts have been documented in two captive Malayan sun bears (Helarctos malayanus) located in zoological parks in Taiwan. Developmental stages of Cryptosporidium parvum were observed in tissue sections from the small intestine of a black bear cub found dead in Virginia (USA).

  12. Bearing-Mounting Concept Accommodates Thermal Expansion

    Science.gov (United States)

    Nespodzany, Robert; Davis, Toren S.

    1995-01-01

    Pins or splines allow radial expansion without slippage. Design concept for mounting rotary bearing accommodates differential thermal expansion between bearing and any structure(s) to which bearing connected. Prevents buildup of thermal stresses by allowing thermal expansion to occur freely but accommodating expansion in such way not to introduce looseness. Pin-in-slot configuration also maintains concentricity.

  13. Estudio de las Propiedades Anticorrosivas del Benzoato de Hierro (III en Pinturas Base Solvente Study of Anticorrosive Properties of the Iron (III Benzoate in Solvent Based Paints

    Directory of Open Access Journals (Sweden)

    Guillermo Blustein

    2006-01-01

    Full Text Available La acción inhibidora del benzoato de hierro en electrodos de acero SAE 1010 en contacto con una suspensión acuosa fue estudiada mediante ensayos electroquímicos. Paralelamente, la eficiencia anticorrosiva de este producto incorporado a cubiertas orgánicas base solvente fue evaluada mediante ensayos de envejecimiento acelerado (cámara de niebla salina y de humedad. La evolución del comportamiento protector de la cubierta aplicada sobre paneles de acero pintados e inmersos en una solución 0.5M de NaClO4 fue periódicamente monitoreada por espectroscopía de impedancia electroquímica. Los resultados obtenidos indican que las pinturas formuladas con benzoato férrico presentan una capacidad anticorrosiva comparable a las formuladas con fosfato de cinc.This study investigated the inhibitory action of iron benzoate on SAE 1010 steel electrodes in aqueous suspensions using electrochemical assays. The anticorrosive efficiency of this product added to organic solvent-based coatings was also evaluated by means of accelerated weathering tests (salt spray cabinet and humidity chamber. The evolution of the protective behavior of the coating applied on steel panels and immersed in 0.5M NaClO4 solution was periodically checked by electrochemical impedance spectroscopy. The results obtained showed that paints formulated with ferric benzoate provide anticorrosive protection similar to those formulated with zinc phosphate.

  14. Nociceptive behaviors were induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious adult rats and reduced by morphine and rizatriptan benzoate.

    Science.gov (United States)

    Dong, Zhao; Jiang, Lei; Wang, Xiaohui; Wang, Xiaolin; Yu, Shengyuan

    2011-01-12

    The trigeminovascular nociception induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus in anesthetized animals has been widely used as a model for investigation of the pathophysiology of vascular headache such as migraine. However, little is known whether pain behaviors can be induced using this model in conscious animals. Thus, to establish a new model of trigeminovascular nociception in conscious animals and to examine the effects of morphine and rizatriptan benzoate on nociceptive behaviors in this new model, we electrically stimulated the dura mater surrounding the superior sagittal sinus. We found that grooming and head-flick activities were altered partially in a frequency-dependent way and that frequencies ranging from 10 to 20 Hz more easily provoked these behaviors. Moreover, we also demonstrated that these behaviors were reduced by morphine and rizatriptan benzoate. Thus, this new model will provide a useful and appropriate tool to directly assess changes in the intensity of pain for further investigation of pathophysiological mechanisms of migraine in conscious animals.

  15. Fixation of chiral smectic liquid crystal (S)-(+)-4-(2-methyl-1-butyloyloxy)phenyl 4-[1-(propenoyloxy) butiloxy] benzoate using UV curing techniques

    Energy Technology Data Exchange (ETDEWEB)

    Afrizal,, E-mail: rizalunj04@yahoo.com; Nurdelima,; Umeir [Faculty of Mathemathics and Natural Science, University of State Jakarta, Jakarta (Indonesia); Hikam, Muhammad; Soegiyono, Bambang [Department of Materials Science, University of Indonesia, Depok (Indonesia); Riswoko, Asep [Center for Material Technology, BPPT, Jl. MH.Thamrin 8 Jakarta (Indonesia)

    2014-03-24

    Chiral Smectic Liquid Crystal (S)-(+)-4-(2-methyl-1-butyloyloxy)phenyl 4-[1-(propenoyloxy) butiloxy] benzoate has been synthesized using method of steglich esterification at room temperature. The mesomorphic behavior of chiral smectic at 55°C that showed schlieren texture in POM analysis. Fixation of structure chiral smectic liquid crystal by means of photopolymerization of monomer (S)-(+)-4-(2-methyl-1-butyloyloxy)phenyl 4-[1-(propenoyloxy) butiloxy] benzoate under UV irradiation which called UV curing techniques. The curing process using UV 3 lamps 100 volt at 60°C for an hour. The product of photopolymerization could be seen by analysis of FTIR spectra both monomer and polymer. FTIR spectra of monomer, two peaks for ester carbonyl and C-C double bond groups appeared at 1729.09 cm-1and 3123.46 cm{sup −1}. After UV curing process, peak for the carbonyl group at 1729.09 cm{sup −1} decreased and a new peak at 1160.21 cm{sup −1} appeared due to the carbonyl group attached to a C-C bond group and then peak at 3123.46 cm{sup −1} for C-C double bond group was disappeared.

  16. Microbial evolution during storage of seasoned olives prepared with organic acids with potassium sorbate, sodium benzoate, and ozone used as preservatives.

    Science.gov (United States)

    Arroyo López, F N; Durán Quintana, M C; Garrido Fernández, A

    2006-06-01

    The effect of potassium sorbate, sodium benzoate, and ozone in combination with citric, lactic, and acetic acids on the microbial population of seasoned table olives of the olive 'Aloreña' cultivar was studied in both fresh (FF) and stored fruits (SF). The inactivation/growth curves were modeled and the biological parameters estimated, with yeast used as the target microorganism. Regardless of the acid added, potassium sorbate showed a general inactivation effect on yeasts in the products prepared from both FF and SE Sodium benzoate had a rapid inactivation effect with FF, but with SF, it was effective only in the presence of acetic acid. A strain of Issatchenkia occidentalis was found that was resistant to the combination of this preservative with citric or lactic acids. In FF, ozone showed an initial marked inhibition against yeasts, but later, yeasts were again able to grow. In SF, ozone was a strong inactivating agent when it replaced any of the traditional preservatives. Lactic acid bacteria were always absent in products prepared from FF, and apparently were not affected by the different preservative agents in those prepared from SF. The behavior of yeasts and lactic acid bacteria populations in commercial products were similar to those found in experimental treatments.

  17. Inhibitor effects of sodium benzoate on corrosion resistance of Al6061-B4C composites in NaCl and H3BO3 solutions

    Science.gov (United States)

    Rafi-ud-din; Shafqat, Q. A.; Shahzad, M.; Ahmad, Ejaz; Asghar, Z.; Rafiq, Nouman; Qureshi, A. H.; Syed, Waqar adil; asim Pasha, Riffat

    2016-12-01

    Sodium benzoate (SB) is used for the first time to inhibit the corrosion of Al6061-B4C composites in H3BO3 and NaCl solutions. Al6061100-x -x wt% B4C (x = 0, 5, and 10) composites are manufactured by a powder metallurgy route. The corrosion inhibition efficiency of SB is investigated as a function of the volume fractions of B4C particles by using potentiodynamic polarization and electrochemical impedance techniques. Without the use of an inhibitor, an increase of the B4C particles in the composite decreases the corrosion resistance of Al6061-B4C composites. It is found that SB is an efficient corrosion inhibitor for Al6061-B4C composites in both investigated solutions. The corrosion inhibition efficiency of SB increases with an increase in B4C content. Since SB is an adsorption type inhibitor, it is envisaged that an extremely thin layer of molecules adsorbs onto the surface and suppresses the oxidation and reduction. It is found that the inhibitor effect of SB is more pronounced in a H3BO3 environment than in NaCl solution. Further, the mechanism of corrosion inhibition by SB is illustrated by using optical and scanning electron microscopy of corroded samples. It is found that the adsorption of benzoate ions on the Al surface and its bonding with Al3+ ions forms a hydrophobic layer on top of the exposed Al surface, which enhances the protection against dissolved boride ions.

  18. Cannibalism and predation on black bears by grizzly bears in the Yellowstone ecosystem, 1975-1990

    Science.gov (United States)

    Mattson, D.J.; Knight, R.R.; Blanchard, B.M.

    1992-01-01

    We documented one instance of an adult male grizzly bear preying upon a black bear and four instances where circumstantial evidence suggested that grizzly bears (two cubs-of-the-year, one yearling female that was injured, and one adult male) had been preyed upon by conspecifics. We also examined feces of grizzly bears for bear remains. Remains of bears tended to be more common in spring feces and did not differ in frequency between early and late years of the study. Our observations generally support existing hypotheses concerning cannibalism among bears.

  19. Improvement of journal bearing operation at heavy misalignment using bearing flexibility and compliant liners

    DEFF Research Database (Denmark)

    Thomsen, Kim; Klit, Peder

    2012-01-01

    A flexure journal bearing design is proposed that will improve operational behaviour of a journal bearing at pronounced misalignment. Using a thermoelastohydrodynamic model, it is shown that the proposed flexure journal bearing has vastly increased the hydrodynamic performance compared to the stiff...... bearing when misaligned. The hydrodynamic performance is evaluated on lubricant film thickness, pressure and temperature. Furthermore, the influence of a compliant bearing liner is investigated and it is found that it increases the hydrodynamic performance when applied to a stiff bearing, whereas...... the liner has practically no influence on the flexure journal bearing's performance....

  20. Ball Bearing Stacking Automation System

    Directory of Open Access Journals (Sweden)

    Shafeequerrahman S . Ahmed

    2013-01-01

    Full Text Available This document is an effort to introduce the concept of automation in small scale industries and or small workshops that are involved in the manufacturing of small objects such as nuts, bolts and ball bearing in this case. This an electromechanical system which includes certain mechanical parts that involves one base stand on which one vertical metallic frame is mounted and hinged to this vertical stand is an in humanized effort seems inadequate in this era making necessary the use of Electronics, Computer in the manufacturing processes leading to the concept of Automated Manufacturing System (AMS.The ball bearing stack automation is an effort in this regard. In our project we go for stack automation for any object for example a ball bearing, be that is still a manual system there. It will be microcontroller based project control system equipped with microcontroller 89C51 from any manufacturer like Atmel or Philips. This could have been easily implemented if a PLC could be used for manufacturing the staking unit but I adopted the microcontroller based system so that some more modification in the system can be effected at will as to use the same hardware .Although a very small object i.e. ball bearig or small nut and fixture will be tried to be stacked, the system with more precision and more power handling capacity could be built for various requirements of the industry. For increasing more control capacity, we can use another module of this series. When the bearing is ready, it will be sent for packing. This is sensed by an inductive sensor. The output will be proceeds by PLC and microcontroller card which will be driving the assembly in order to put it into pads or flaps. This project will also count the total number of bearings to be packed and will display it on a LCD for real time reference and a provision is made using a higher level language using hyper terminal of the computer

  1. Shaft Center Orbit in Dynamically Loaded Bearings

    DEFF Research Database (Denmark)

    Klit, Peder

    The aim of this work is to demonstrate how to utilize the bearings damping coefficients to estimate the orbit for a dynamically loaded journal bearing. The classical method for this analysis was developed by Booker in 1965 and described further in 1972. Several authors have refined this method over...... Jorgen W. Lund pointed out in lecture notes that the dynamic damping coefficients of the bearing could be used to find the shaft orbit for dynamically loaded bearings. For simplicity the "Short-Width-Journal-Bearing Theory" is used as a basis for finding the damping coefficients in this work...

  2. Chromatographic (TLC) differentiation of grizzly bear and black bear scats

    Science.gov (United States)

    Picton, Harold D.; Kendall, Katherine C.

    1994-01-01

    While past work concluded that thin-layer chromatography (TLC) was inadequate for the separation of grizzly (Ursus arctos horribilis) and black bear (U. americanus) scats, our study found differences adequate for species separation. A key was constructed using 19 of 40 data points recorded on each(N)=356 profiles of 178) know-species scat. Accuracy was best for late summer scats (94%). Methods for specimen preparation, analysis, and reading the TLC profiles are discussed. Factors involved in scat variation were tested.

  3. Pratt and Whitney cryogenic turbopump bearing experience

    Science.gov (United States)

    Poole, W. E.; Bursey, R. W., Jr.

    1988-01-01

    Successful, reusable bearings require lubrication, traditionally, a transfer film from sacrificial cage wear. Early testing included materials screening programs to identify suitable cryogenic cage materials. A specially developed element tester that simulated the function of a ball bearing cage was used. Suitable materials must provide lubrication with an acceptably low wear rate, without abrading contacting surfaces. The most promising materials were tested in full scale bearings at speeds up to 4 MDN. Teflon, filled with 40 percent bronze powder, was the best performing material. A variety of bearings were designed and successfully tested in LH2 and LOX. Bearings with bronze filled Teflon cages were successfully tested for 150 hrs. In overload tests, the same design was tested for 5 hrs at maximum Hertz stresses above 450 ksi and an additional 5 hrs with a maximum Hertz stress exceeding 500 ksi. Four bearings were tested in LOX for 25 hrs, with a maximum time per bearing of 10 hrs.

  4. Design, synthesis and in vitro antibacterial activities of methyl-4-((substituted phenyl) [6H-indolo (2,3-b)quinoxalin-6-yl]methyl-amino)benzoate derivatives

    Institute of Scientific and Technical Information of China (English)

    Yellajyosula Lakshmi Narasimha Murthy; Nagalakshmi Karthikeyan; Govindh Boddeti; Bhagavathula S. Diwakar; E. Rajendra Singh

    2011-01-01

    A series of new methyl-4-((substituted phenyl) [6H-indolo (2,3-b)quinoxalin-6yllmethylamino)benzoate derivatives have been synthesized and assayed for their antibacterial activity on 9 different bacterial strains. Among the screened compounds 2e-2g exhibited potent inhibitory activity compared to standard drug employed, worth further investigation.

  5. Current leads and magnetic bearings

    Science.gov (United States)

    Hull, J. R.

    1993-10-01

    Since the discovery of high temperature superconductors (HTS's), Argonne National Laboratory (ANL) has been active in a broad spectrum of activities in developing these materials for applications. Work at every stage of development has involved industrial collaboration in order to accelerate commercialization. While most of the development work has been devoted to improving the properties of current-carrying wires, some effort has been devoted to applications that can utilize HTS's with properties available now or in the near future. In this paper, advances made in the area of current leads and magnetic bearings are discussed.

  6. Bearing Health Assessment Based on Chaotic Characteristics

    Directory of Open Access Journals (Sweden)

    Chen Lu

    2013-01-01

    Full Text Available Vibration signals extracted from rotating parts of machinery carry a lot of useful information about the condition of operating machine. Due to the strong non-linear, complex and non-stationary characteristics of vibration signals from working bearings, an accurate and reliable health assessment method for bearing is necessary. This paper proposes to utilize the selected chaotic characteristics of vibration signal for health assessment of a bearing by using self-organizing map (SOM. Both Grassberger-Procaccia algorithm and Takens' theory are employed to calculate the characteristic vector which includes three chaotic characteristics, such as correlation dimension, largest Lyapunov exponent and Kolmogorov entropy. After that, SOM is used to map the three corresponding characteristics into a confidence value (CV which represents the health state of the bearing. Finally, a case study based on vibration datasets of a group of testing bearings was conducted to demonstrate that the proposed method can reliably assess the health state of bearing.

  7. The Fos expression in rat brain following electrical stimulation of dura mater surrounding the superior sagittal sinus changed with the pre-treatment of rizatriptan benzoate.

    Science.gov (United States)

    Wang, Xiaolin; Yu, Shengyuan; Dong, Zhao; Jiang, Lei

    2011-01-07

    Fos expression in the brain was systematically investigated by means of immunohistochemical staining after electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious rats. Fos-like immunoreactive neurons are distributed mainly in the upper cervical spinal cord, spinal trigeminal nucleus caudal part, raphe magnus nucleus, periaqueductal gray, ventromedial hypothalamic nucleus, and mediodorsal thalamus nucleus. With the pre-treatment of intraperitoneal injection of rizatriptan benzoate, the number of Fos-like immunoreactive neurons decreased in the spinal trigeminal nucleus caudal part and raphe magnus nucleus, increased in the periaqueductal gray, and remained unchanged in the ventromedial hypothalamic nucleus and mediodorsal thalamus nucleus. These results provide morphological evidence that the nuclei described above are involved in the development and maintenance of the trigeminovascular headache.

  8. Effect of sodium benzoate on DNA breakage, micronucleus formation and mitotic index in peripheral blood of pregnant rats and their newborns

    Directory of Open Access Journals (Sweden)

    Cetin Saatci

    2016-11-01

    Full Text Available Sodium benzoate (SB is one of the most widely used additives in food products in the world. The aim of this study was to assess the effect of three different concentrations of SB on the DNA breakage in liver cells and on the micronuclei formation and the mitotic index in lymphocytes of pregnant rats and their fetuses, as well as to evaluate the effects of SB on the fetus development. The results showed that general genomic injuries were present in almost all the liver cell samples obtained from the SB group compared with the control (non-treated group. This indicates that SB usage may cause DNA damage and increase micronuclei formation. We recommend that pregnant women should avoid consuming foodstuffs containing SB as an additive.

  9. Excess parameters for binary mixtures of ethyl benzoate with 1-propanol, 1-butanol and 1-pentanol at T=303, 308, 313, 318, and 323 K

    Energy Technology Data Exchange (ETDEWEB)

    Sreehari Sastry, S., E-mail: sreeharisastry@yahoo.com [Department of Physics, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh 522 510 (India); Babu, Shaik, E-mail: babu.computers@gmail.com [Department of Physics, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh 522 510 (India); Vishwam, T., E-mail: vishwam@gitam.edu [Department of Engineering Physics, Gitam University, Hyderabad Campus, Andhra Pradesh 502 239 (India); Parvateesam, K., E-mail: kps27031966@gmail.com [Department of Physics, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh 522 510 (India); Sie Tiong, Ha., E-mail: hast@utar.edu.my [Faculty of Science, Department of Chemical Science, Universiti Tunku Abdul Rahman, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak (Malaysia)

    2013-07-01

    Various thermo–acoustic parameters, such as excess isentropic compressibility (K{sub s}{sup E}), excess molar volume (V{sup E}), excess free length (L{sub f}{sup E}), excess Gibb's free energy (ΔG{sup *E}), and excess Enthalpy (H{sup E}), have been calculated from the experimentally determined data of density, viscosity and speed of sound for the binary mixtures of ethyl benzoate+1-propanol, or +1-butanol, or +1-pentanol over the entire range of composition at different temperatures (303, 308, 313, 318 and 323 K). The excess functions have been fitted to the Redlich–Kister type polynomial equation. The deviations for excess thermo–acoustic parameters have been explained on the basis of the intermolecular interactions present in these binary mixtures.

  10. Identification of the novel synthetic cannabimimetic 8-quinolinyl 4-methyl-3-(1-piperidinylsulfonyl)benzoate (QMPSB) and other designer drugs in herbal incense.

    Science.gov (United States)

    Blakey, Karen; Boyd, Sue; Atkinson, Sarah; Wolf, Jenna; Slottje, Pim M; Goodchild, Katrina; McGowan, Jenny

    2016-03-01

    The identification and structural elucidation of the novel synthetic cannabimimetic 8-quinolinyl 4-methyl-3-(1-piperidinylsulfonyl)benzoate (QMPSB) by GC-MS, LC-MS and NMR is reported. QMPSB was identified in Queensland, Australia on plant material packaged as herbal incense. The identification of QMPSB was initially hampered due to trans-esterification occurring in the extraction solvent. An investigation of the trans-esterification of QMPSB in methanol and ethanol was conducted and analytical data for the respective methyl and ethyl esters are reported. Analytical data is presented for two other compounds detected on seized plant material packaged as herbal incense: the synthetic cannabimimetic 1-[(N-methylpiperidin-2-yl)methyl]-3-(4-methyl-1-naphthoyl)indole (MAM-1220) and the JWH-081 analogue 1-(cyclohexylmethyl)-3-(4-methoxy-1-naphthoyl)indole (CHM-081).

  11. Electromechanical properties of radial active magnetic bearings

    OpenAIRE

    Antila, Matti

    1998-01-01

    Nonideal properties of the electromagnetic actuators in radial active magnetic bearings are studied. The two dimensional nonlinear stationary finite element method is used to determine the linearised parameters of a radial active magnetic bearing. The method is verified on two test machines. The accuracy is 10-15 % in the magnetic saturation region. The effect of magnetic saturation on the bearing dynamics is studied based on the root locus diagrams of the closed loop system. These diagrams s...

  12. Powder-Metallurgical Bearings For Turbopumps

    Science.gov (United States)

    Bhat, B. N.; Humphries, T. S.; Thom, R. L.; Moxson, V.; Friedman, G. I.; Dolan, F. J.; Shipley, R. J.

    1993-01-01

    Bearings fabricated by powder metallurgy developed for use in machines subjected to extremes of temperature, rolling-contact cyclic stresses, and oxidizing or otherwise corrosive fluids. Bearings also extend operating lives of other machines in which bearings required to resist extreme thermal, mechanical, and chemical stresses. One alloy exhibiting outstanding properties was MRC-2001. Resistance to fatigue, stress corrosion cracking, and wear found superior to that of 440C stainless steel.

  13. Are organohalogen contaminants a bears (Ursus maritimus)?

    DEFF Research Database (Denmark)

    Sonne, Christian; Dietz, Rune; Leifsson, PS

    2006-01-01

    Tissues of polar bears (Ursus maritimus) from East Greenland contain the highest concentrations of organohalogen contaminants (OHCs) among subpopulations of any mammalian species in the Arctic. Negative associations also have been found between OHC concentrations and bone mineral density and liver...... histology parameters for this subpopulation of polar bears. The present study examined the OHC concentrations and adverse effects on renal tissue for 75 polar bears collected during 1999 to 2002. Specific lesions were diffuse glomerular capillary wall thickening, mesangial glomerular deposits, tubular...

  14. LC-MS/MS Analysis and Pharmacokinetics of Sodium (±-5-Bromo-2-(α-hydroxypentyl Benzoate (BZP, an Innovative Potent Anti-Ischemic Stroke Agent in Rats

    Directory of Open Access Journals (Sweden)

    Xin Tian

    2016-04-01

    Full Text Available A rapid, sensitive and selective liquid chromatography-triple quadrupole mass spectrometry (LC-MS/MS method was developed and validated for the simultaneous determination of sodium (±-5-Bromo-2-(α-hydroxypentyl benzoate (BZP and its active metabolite 3-butyl-6-bromo-1(3H-isobenzofuranone (Br-NBP in rat plasma using potassium 2-(1-hydroxypentyl-benzoate (PHPB and l-3-n-butylphthalide (NBP as internal standards (IS. Chromatographic separation was achieved on a Hypersil GOLD C18 column using a gradient elution of ammonium acetate and methanol at a flow rate of 0.2 mL/min. Good linearity was achieved within the wide concentration range of 5–10,000 ng/mL. The intra-day and inter-day precision was less than 8.71% and the accuracy was within −8.53% and 6.38% in quality control and the lower limit of quantitation samples. BZP and Br-NBP were stable during the analysis and the storage period. The method was successfully applied to pharmacokinetic studies of BZP in Sprague-Dawley rats for the first time. After a single intravenous administration of BZP at the dose of 0.75 mg/kg, the plasma concentration of BZP and Br-NBP declined rapidly and the AUC0-t of BZP was significantly greater in female rats compared to male rats (p < 0.05. The data presented in this study serve as a firm basis for further investigation of BZP in both preclinical and clinical phases.

  15. Gearbox Reliability Collaborative Bearing Calibration

    Energy Technology Data Exchange (ETDEWEB)

    van Dam, J.

    2011-10-01

    NREL has initiated the Gearbox Reliability Collaborative (GRC) to investigate the root cause of the low wind turbine gearbox reliability. The GRC follows a multi-pronged approach based on a collaborative of manufacturers, owners, researchers and consultants. The project combines analysis, field testing, dynamometer testing, condition monitoring, and the development and population of a gearbox failure database. At the core of the project are two 750kW gearboxes that have been redesigned and rebuilt so that they are representative of the multi-megawatt gearbox topology currently used in the industry. These gearboxes are heavily instrumented and are tested in the field and on the dynamometer. This report discusses the bearing calibrations of the gearboxes.

  16. Evaluation of bearing configurations using the single bearing tester in liquid nitrogen

    Science.gov (United States)

    Jett, T.; Hall, P.; Thom, R.

    1991-01-01

    Various bearing configurations were tested using the Marshall Space Flight Center single bearing tester with LN2 as the cryogenic coolant. The baseline was one Rocketdyne phase one high pressure oxidizer turbopump (HPOTP) pump end 45-mm bore bearing. The bearing configurations that were tested included a Salox/M cage configuration, a silicon nitride ball configuration, an elongated cage configuration, and a Bray 601 grease configuration.

  17. Rotor-Bearing Dynamics Technology Design Guide. Part 4. Cylindrical Roller Bearings

    Science.gov (United States)

    1979-12-01

    ýbluck ,,lb.,mb i Tapered Roller Bearings Roller Beating Stiffness Tapered Roller Bearing Stiffness Turbine Bearings VRoller Bearings Rotordynamics ...input for rotordynamic response programs. The complete stiffness matrix is calculated including centrifugal effects. Considerations such as elastohydro...those parts directly connected with preparation of input for the rotordynamic response programs (Part 1(5) of the revised series) were retained. The

  18. State Space Formulation of Nonlinear Vibration Responses Collected from a Dynamic Rotor-Bearing System: An Extension of Bearing Diagnostics to Bearing Prognostics

    Directory of Open Access Journals (Sweden)

    Peter W. Tse

    2017-02-01

    Full Text Available Bearings are widely used in various industries to support rotating shafts. Their failures accelerate failures of other adjacent components and may cause unexpected machine breakdowns. In recent years, nonlinear vibration responses collected from a dynamic rotor-bearing system have been widely analyzed for bearing diagnostics. Numerous methods have been proposed to identify different bearing faults. However, these methods are unable to predict the future health conditions of bearings. To extend bearing diagnostics to bearing prognostics, this paper reports the design of a state space formulation of nonlinear vibration responses collected from a dynamic rotor-bearing system in order to intelligently predict bearing remaining useful life (RUL. Firstly, analyses of nonlinear vibration responses were conducted to construct a bearing health indicator (BHI so as to assess the current bearing health condition. Secondly, a state space model of the BHI was developed to mathematically track the health evolution of the BHI. Thirdly, unscented particle filtering was used to predict bearing RUL. Lastly, a new bearing acceleration life testing setup was designed to collect natural bearing degradation data, which were used to validate the effectiveness of the proposed bearing prognostic method. Results show that the prediction accuracy of the proposed bearing prognostic method is promising and the proposed bearing prognostic method is able to reflect future bearing health conditions.

  19. Precision instrumentation for rolling element bearing characterization

    Science.gov (United States)

    Marsh, Eric R.; Vigliano, Vincent C.; Weiss, Jeffrey R.; Moerlein, Alex W.; Vallance, R. Ryan

    2007-03-01

    This article describes an instrument to measure the error motion of rolling element bearings. This challenge is met by simultaneously satisfying four requirements. First, an axial preload must be applied to seat the rolling elements in the bearing races. Second, one of the races must spin under the influence of an applied torque. Third, rotation of the remaining race must be prevented in a way that leaves the radial, axial/face, and tilt displacements free to move. Finally, the bearing must be fixtured and measured without introducing off-axis loading or other distorting influences. In the design presented here, an air bearing reference spindle with error motion of less than 10 nm rotates the inner race of the bearing under test. Noninfluencing couplings are used to prevent rotation of the bearing outer race and apply an axial preload without distorting the bearing or influencing the measurement. Capacitive displacement sensors with 2 nm resolution target the nonrotating outer race. The error motion measurement repeatability is shown to be less than 25 nm. The article closes with a discussion of how the instrument may be used to gather data with sufficient resolution to accurately estimate the contact angle of deep groove ball bearings.

  20. Can polar bear hairs absorb environmental energy?

    OpenAIRE

    He Ji-Huan; Wang Qing-Li; Sun Jie

    2011-01-01

    A polar bear (Ursus maritimus) has superior ability to survive in harsh Arctic regions, why does the animal have such an excellent thermal protection? The present paper finds that the unique labyrinth cavity structure of the polar bear hair plays an important role. The hair can not only prevent body temperature loss but can also absorb energy from the environment.

  1. Can polar bear hairs absorb environmental energy?

    Directory of Open Access Journals (Sweden)

    He Ji-Huan

    2011-01-01

    Full Text Available A polar bear (Ursus maritimus has superior ability to survive in harsh Arctic regions, why does the animal have such an excellent thermal protection? The present paper finds that the unique labyrinth cavity structure of the polar bear hair plays an important role. The hair can not only prevent body temperature loss but can also absorb energy from the environment.

  2. Movie Director Bags a Silver Bear

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Chinese director and film writer Wang Xiaoshuai has walked away with the Silver Bear award at the 58th Berlin International Film Festival for best script of Zuo You, or In Love We Trust. Back in 2001, Wang won his first Silver Bear award for directing Beijing

  3. Shaft Center Orbit in Dynamically Loaded Bearings

    DEFF Research Database (Denmark)

    Klit, Peder

    2005-01-01

    The aim of this work is to demonstrate how to utilize the bearings damping coe±cients to estimate the orbit for a dynamically loaded journal bearing. The classical method for this analysis was developed by Booker in 1965 [1]and described further in 1972 [2]. Several authors have re¯ned this method...... seventies Jorgen W. Lund pointed out in lecture notes that the dynamic damping coe±cients of the bearing could be used to ¯nd the shaft orbit for dynamically loaded bearings. For simplicity the "Short-Width-Journal-Bearing Theory" is used as a basis for ¯nding the damping coe±cients in this work...

  4. Trends in Controllable Oil Film Bearings

    DEFF Research Database (Denmark)

    Santos, Ilmar

    2011-01-01

    This work gives an overview about the theoretical and experimental achievements of mechatronics applied to oil film bearings, with the aim of: controlling the lateral vibration of flexible rotating shafts; modifying bearing dynamic characteristics, as stiffness and damping properties; increasing...... the rotational speed ranges by improving damping and eliminating instability problems, for example, by compensating cross-coupling destabilizing effects; reducing startup torque and energy dissipation in bearings; compensating thermal effects. It is shown that such controllable bearings can act as "smart......" components and be applied to rotating machines with the goal of avoiding unexpected stops of plants, performing rotordynamic tests and identifying model parameters "on site". Emphasis is given to the controllable lubrication (active lubrication) applied to different types of oil film bearings, i...

  5. Geology and geomorphology of Bear Lake Valley and upper Bear River, Utah and Idaho

    Science.gov (United States)

    Reheis, M.C.; Laabs, B.J.C.; Kaufman, D.S.

    2009-01-01

    Bear Lake, on the Idaho-Utah border, lies in a fault-bounded valley through which the Bear River flows en route to the Great Salt Lake. Surficial deposits in the Bear Lake drainage basin provide a geologic context for interpretation of cores from Bear Lake deposits. In addition to groundwater discharge, Bear Lake received water and sediment from its own small drainage basin and sometimes from the Bear River and its glaciated headwaters. The lake basin interacts with the river in complex ways that are modulated by climatically induced lake-level changes, by the distribution of active Quaternary faults, and by the migration of the river across its fluvial fan north of the present lake. The upper Bear River flows northward for ???150 km from its headwaters in the northwestern Uinta Mountains, generally following the strike of regional Laramide and late Cenozoic structures. These structures likely also control the flow paths of groundwater that feeds Bear Lake, and groundwater-fed streams are the largest source of water when the lake is isolated from the Bear River. The present configuration of the Bear River with respect to Bear Lake Valley may not have been established until the late Pliocene. The absence of Uinta Range-derived quartzites in fluvial gravel on the crest of the Bear Lake Plateau east of Bear Lake suggests that the present headwaters were not part of the drainage basin in the late Tertiary. Newly mapped glacial deposits in the Bear River Range west of Bear Lake indicate several advances of valley glaciers that were probably coeval with glaciations in the Uinta Mountains. Much of the meltwater from these glaciers may have reached Bear Lake via groundwater pathways through infiltration in the karst terrain of the Bear River Range. At times during the Pleistocene, the Bear River flowed into Bear Lake and water level rose to the valley threshold at Nounan narrows. This threshold has been modified by aggradation, downcutting, and tectonics. Maximum lake

  6. Accumulation profiles of parabens and their metabolites in fish, black bear, and birds, including bald eagles and albatrosses.

    Science.gov (United States)

    Xue, Jingchuan; Kannan, Kurunthachalam

    2016-09-01

    Although several studies have reported the ubiquitous occurrence of parabens in human specimens and the environment, little is known about the accumulation of these estrogenic chemicals in fish and birds. In this study, accumulation profiles of six parabens and their metabolites were determined in 254 tissue (including liver, kidney, egg, and plasma) samples from 12 species of fish and seven species of birds collected from inland, coastal, and remote aquatic ecosystems. In addition, liver and kidney tissues from black bears were analyzed. Methyl paraben (MeP) was found in a majority of the tissues, with the highest concentration (796ng/g (wet weight [wet wt])) found in the liver of a bald eagle from Michigan. 4-Hydroxy benzoate (HB) was the major metabolite, found in 91% of the tissue samples analyzed at concentrations as high as 68,600ng/g, wet wt, which was found in the liver of a white-tailed sea eagle from the Baltic Sea coast. The accumulation pattern of MeP and 4-HB varied, depending on the species. The mean concentrations of MeP measured in fishes from Michigan, New York, and Florida waters were environment.

  7. THE STRUCTURAL ANALYSIS OF STEEL SILOS WITH CYLINDRICAL-WALL BEARING AND PROFILE-STEEL BEARING

    Directory of Open Access Journals (Sweden)

    Zhengjun Tang

    2015-04-01

    Full Text Available The silos are widely used in bulk material in many fields such as agriculture, mining, chemical, electric power storage, etc. Thin metal cylindrical silo shells are vulnerable to buckling failure caused by the compressive wall friction force. In this paper, the structural analysis of two types of steel silo with cylindrical-wall bearing and profile-steel bearing is implemented by Abaqus finite element analysis. The results indicate that under the same loading conditions, steel silos with profile-steel bearing and cylindrical-Wall bearing have similar values in Mises stress, but the steel silo with profile-steel bearing has a smaller radial displacement and a better capability of buckling resistance. Meanwhile, the total steel volumes reduced 8.0% comparing to the steel silo with cylindrical-wall bearing. Therefore, steel soil with profile-steel bearing not only has a less steel volumes but also a good stability.

  8. Radiation tolerance in water bears.

    Science.gov (United States)

    Horikawa, D. D.; Sakashita, T.; Katagiri, C.; Watanabe, M.; Nakahara, Y.; Okuda, T.; Hamada, N.; Wada, S.; Funayama, T.; Kobayashi, Y.

    Tardigrades water bears are tiny invertebrates forming a phylum and inhabit various environments on the earth Terrestrial tardigrades enter a form called as anhydrobiosis when the surrounding water disappears Anhyydrobiosis is defined as an ametabolic dry state and followed by recovering their activity when rehydrated Anhydrobiotic tardigrades show incredible tolerance to a variety of extreme environmental conditions such as temperatures -273 r C to 151 r C vacuum high pressure 600 MPa and chemicals that include alcohols and methyl bromide In these views there have been some discussions about their potential for surviving outer space In the present study we demonstrated the survival limit not merely against gamma-rays but against heavy ions in the tardigrade Milnesium tardigradum in order to evaluate the effects of radiations on them The animals were exposure to 500 to 7000 Gy of gamma-rays or 500 to 8000 Gy of heavy ions 4 He in their hydrated or anhydrobiotic state The results showed that both of hydrated and anhydrobiotic animals have high radio-tolerance median lethal dose LD50 48 h of gamma-rays or heavy ions in M tardigradum was more than 4000 Gy indicating that this species is categorized into the most radio-tolerant animals We suggest that tardigrades will be suitable model animals for extremophilic multicellular organisms and may provide a survival strategy in extraterrestrial environments

  9. Grizzly bear diet shifting on reclaimed mines

    Directory of Open Access Journals (Sweden)

    Bogdan Cristescu

    2015-07-01

    Full Text Available Industrial developments and reclamation change habitat, possibly altering large carnivore food base. We monitored the diet of a low-density population of grizzly bears occupying a landscape with open-pit coal mines in Canada. During 2009–2010 we instrumented 10 bears with GPS radiocollars and compared their feeding on reclaimed coal mines and neighboring Rocky Mountains and their foothills. In addition, we compared our data with historical bear diet for the same population collected in 2001–2003, before extensive mine reclamation occurred. Diet on mines (n=331 scats was dominated by non-native forbs and graminoids, while diets in the Foothills and Mountains consisted primarily of ungulates and Hedysarum spp. roots respectively, showing diet shifting with availability. Field visitation of feeding sites (n=234 GPS relocation clusters also showed that ungulates were the main diet component in the Foothills, whereas on reclaimed mines bears were least carnivorous. These differences illustrate a shift to feeding on non-native forbs while comparisons with historical diet reveal emergence of elk as an important bear food. Food resources on reclaimed mines attract bears from wilderness areas and bears may be more adaptable to landscape change than previously thought. The grizzly bear’s ready use of mines cautions the universal view of this species as umbrella indicative of biodiversity.

  10. Genomic sequencing of Pleistocene cave bears

    Energy Technology Data Exchange (ETDEWEB)

    Noonan, James P.; Hofreiter, Michael; Smith, Doug; Priest, JamesR.; Rohland, Nadin; Rabeder, Gernot; Krause, Johannes; Detter, J. Chris; Paabo, Svante; Rubin, Edward M.

    2005-04-01

    Despite the information content of genomic DNA, ancient DNA studies to date have largely been limited to amplification of mitochondrial DNA due to technical hurdles such as contamination and degradation of ancient DNAs. In this study, we describe two metagenomic libraries constructed using unamplified DNA extracted from the bones of two 40,000-year-old extinct cave bears. Analysis of {approx}1 Mb of sequence from each library showed that, despite significant microbial contamination, 5.8 percent and 1.1 percent of clones in the libraries contain cave bear inserts, yielding 26,861 bp of cave bear genome sequence. Alignment of this sequence to the dog genome, the closest sequenced genome to cave bear in terms of evolutionary distance, revealed roughly the expected ratio of cave bear exons, repeats and conserved noncoding sequences. Only 0.04 percent of all clones sequenced were derived from contamination with modern human DNA. Comparison of cave bear with orthologous sequences from several modern bear species revealed the evolutionary relationship of these lineages. Using the metagenomic approach described here, we have recovered substantial quantities of mammalian genomic sequence more than twice as old as any previously reported, establishing the feasibility of ancient DNA genomic sequencing programs.

  11. Space Telescope Fine Guidance Sensor Bearing Anomaly

    Science.gov (United States)

    Loewenthal, S.; Esper, J.; Pan, J.; Decker, J.

    1996-01-01

    Early in 1993, a servo motor within one of three Fine Guidance Sensors (FGS) aboard the Hubble Space Telescope (HST) reached stall torque levels on several occasions. Little time was left to plan replacement during the first servicing mission, scheduled at the end of '93. Accelerated bearing life tests confirmed that a small angle rocking motion, known as Coarse Track (CT), accelerated bearing degradation. Saturation torque levels were reached after approximately 20 million test cycles, similar to the flight bearings. Reduction in CT operation, implemented in flight software, extended FGS life well beyond the first servicing mission. However in recent years, bearing torques have resumed upward trends and together with a second, recent bearing torque anomaly has necessitated a scheduled FGS replacement during the upcoming second servicing mission in '97. The results from two series of life tests to quantify FGS bearing remaining life, discussion of bearing on-orbit performance, and future plans to service the FGS servos are presented in this paper.

  12. Genetics Home Reference: Beare-Stevenson cutis gyrata syndrome

    Science.gov (United States)

    ... Health Conditions Beare-Stevenson cutis gyrata syndrome Beare-Stevenson cutis gyrata syndrome Enable Javascript to view the ... Download PDF Open All Close All Description Beare-Stevenson cutis gyrata syndrome is a genetic disorder characterized ...

  13. Eastern slopes grizzly bear project : project update

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-01-01

    This report updates a study to examine the cumulative effects of human activities on the grizzly bears in the central Canadian Rockies. The project was initiated in 1994 to acquire accurate scientific information on the habitat and populations of grizzly bears in the area of the Banff National Park and Kananaskis Country. This area is probably the most heavily used and developed area where the grizzly still survives. The information gathered throughout the course of the study is used to better protect and manage the bears and other sensitive carnivores in the region. Using telemetry, researchers monitored 25 grizzly bears which were radio-collared in a 22,000 square-kilometer area in the upper Bow Valley drainage of the eastern Alberta slopes. The researchers worked with representatives from Husky Oil and Rigel Energy on the development of the Moose Mountain oil and gas field without adversely affecting the grizzly bear population. Information collected over eight years indicates that the grizzly bears have few and infrequent offspring. Using the information gathered thus far, the location of the Moose Mountain to Jumping Pound pipeline was carefully selected, since the bears suffer from high mortality, and the food and cover had already been compromised by the high number of roads, trails and other human activities in the area. The research concluded in November 2001 provides sufficient information to accurately asses the status of the grizzly bear population and habitat. The data will be analyzed and integrated in 2002 into models that reflect the variables affecting grizzly bears and a final report will be published.

  14. 中心组合设计优化复凝聚法制备甲维盐微囊工艺%Optimization of Technology for Complex Coacervation on Emamectin Benzoate Microcapsule Preparation by Center Composite Design

    Institute of Scientific and Technical Information of China (English)

    陈效忠; 李守君; 李晓凤; 王玉峰; 于莲; 慎爱民; 江欣; 苏瑾; 宗希明

    2012-01-01

    [Aims] Optimized the preparation technology of emamectin-benzoate microcapsule. [Methods] Emamectin-benzoate was encapsulated into microcapsules using gelatin and arabic gum as coating materials by complex coacervation. Mass concentration of the emamectin-benzoate was analysed by UV spectrophotometry and the entrapment rate was reckoned. The entrapment rate was used as index, and the preparation technology was optimized by CCD. [Results] The optimum technology conditions of emamectin benzoate microcapsule was set up. The stirred rate was 600 r/min, the reaction temperature was 47 ℃, the reaction time was 107 min and the entrapment rate was 74.27%. [Conclusions] The deviation between predictive value of CCD and measured value was little, optimize method was feasible, and the entrapment rate was higher than before.%[目的]优化甲维盐微囊制备工艺.[方法]实验以明胶和阿拉伯胶为壁材,采用复凝聚法制备甲维盐微囊.用紫外分光光度法测定甲维盐含量,计算包封率.以包封率为指标,通过中心组合设计对制备工艺进行优化.[结果]复凝聚法制备甲维盐微囊的最佳工艺为600 r/min,47℃,反应107 min,包封率为74.27%.[结论]CCD预测值与实际测量值偏差小,优化方法可行,且包封率较高.

  15. Titanium carbide coatings for aerospace ball bearings

    Science.gov (United States)

    Boving, Hans J.; Haenni, Werner; Hintermann, HANS-E.

    1988-01-01

    In conventional ball bearings, steel to steel contacts between the balls and the raceways are at the origin of microwelds which lead to material transfer, surface roughening, lubricant breakdown, and finally to a loss in the bearing performances. To minimize the microwelding tendencies of the contacting partners it is necessary to modify their surface materials; the solid to solid collisions themselves are difficult to avoid. The use of titanium carbide coated steel balls can bring spectacular improvements in the performances and lifetimes of both oil-grease lubricated and oil-grease free bearings in a series of severe applications.

  16. Hydrostatic, aerostatic and hybrid bearing design

    CERN Document Server

    Rowe, W Brian

    2012-01-01

    Solve your bearing design problems with step-by-step procedures and hard-won performance data from a leading expert and consultant Compiled for ease of use in practical design scenarios, Hydrostatic, Aerostatic and Hybrid Bearing Design provides the basic principles, design procedures and data you need to create the right bearing solution for your requirements. In this valuable reference and design companion, author and expert W. Brian Rowe shares the hard-won lessons and figures from a lifetime's research and consultancy experience. Coverage includes: Clear e

  17. Microeconomic analysis of military aircraft bearing restoration

    Science.gov (United States)

    Hein, G. F.

    1976-01-01

    The risk and cost of a bearing restoration by grinding program was analyzed. A microeconomic impact analysis was performed. The annual cost savings to U.S. Army aviation is approximately $950,000.00 for three engines and three transmissions. The capital value over an indefinite life is approximately ten million dollars. The annual cost savings for U.S. Air Force engines is approximately $313,000.00 with a capital value of approximately 3.1 million dollars. The program will result in the government obtaining bearings at lower costs at equivalent reliability. The bearing industry can recover lost profits during a period of reduced demand and higher costs.

  18. Active magnetic bearings applied to industrial compressors

    Science.gov (United States)

    Kirk, R. G.; Hustak, J. F.; Schoeneck, K. A.

    1993-01-01

    The design and shop test results are given for a high-speed eight-stage centrifugal compressor supported by active magnetic bearings. A brief summary of the basic operation of active magnetic bearings and the required rotor dynamics analysis are presented with specific attention given to design considerations for optimum rotor stability. The concerns for retrofits of magnetic bearings in existing machinery are discussed with supporting analysis of a four-stage centrifugal compressor. The current status of industrial machinery in North America using this new support system is presented and recommendations are given on design and analysis requirements for successful machinery operation of either retrofit or new design turbomachinery.

  19. Rotor Vibration Reduction via Active Hybrid Bearings

    DEFF Research Database (Denmark)

    Nicoletti, Rodrigo; Santos, Ilmar

    2002-01-01

    The use of fluid power to reduce and control rotor vibration in rotating machines is investigated. An active hybrid bearing is studied, whose main objective is to reduce wear and vibration between rotating and stationary machinery parts. By injecting pressurised oil into the oil film, through...... orifices machined in the bearing pads, one can alter the machine dynamic characteristics, thus enhancing its operational range. A mathematical model of the rotor-bearing system, as well as of the hydraulic system, is presented. Numerical results of the system frequency response show good agreement...

  20. On Controllable Elastohydrodynamic Fluid Film Bearings

    DEFF Research Database (Denmark)

    Haugaard, Martin Asger

    This thesis gives a theoretical description of the active tilting-pad journal bearing (ATPJB). It provides the qualified reader with the tools to model an ATPJB, while staying clear of pitfalls. The model is based on well known techniques and allows for local stability analyses, harmonic stationary...... are performed for a tilting-pad journal bearing (TPJB) and an ATPJB under static conditions, followed by a generalisation to dynamic conditions (transient as well as stationary harmonic). These analyses will be of interest to experimentalists, since they permit experiments performed on scaled down test rigs...... the addition of a control system may just as well harm rotor-bearing performance as improve it....

  1. Conical Magnetic Bearing Development and Magnetic Bearing Testing for Extreme Temperature Environments

    Science.gov (United States)

    Keith, Theo G., Jr.; Jansen, Mark

    2004-01-01

    The main proposed research of this grant were: to design a high-temperature, conical magnetic bearing facility, to test the high-temperature, radial magnetic bearing facility to higher speeds, to investigate different backup bearing designs and materials, to retrofit the high-temperature test facility with a magnetic thrust bearing, to evaluate test bearings at various conditions, and test several lubricants using a spiral orbit tribometer. A high-temperature, conical magnetic bearing facility has been fully developed using Solidworks. The facility can reuse many of the parts of the current high-temperature, radial magnetic bearing, helping to reduce overall build costs. The facility has the ability to measure bearing force capacity in the X, Y, and Z directions through a novel bearing mounting design. The high temperature coils and laminations, a main component of the facility, are based upon the current radial design and can be fabricated at Texas A&M University. The coil design was highly successful in the radial magnetic bearing. Vendors were contacted about fabrication of the high temperature lamination stack. Stress analysis was done on the laminations. Some of the components were procured, but due to budget cuts, the facility build up was stopped.

  2. Impact of Equine Chorionic Gonadotropin Associated with Temporary Weaning, Estradiol Benzoate, or Estradiol Cypionate on Timed Artificial Insemination in Primiparous Bos Indicus Cows

    Directory of Open Access Journals (Sweden)

    Andre Luis Bastos Souza

    Full Text Available The study aimed to determine the impact of equine chorionic gonadotropin (eCG associated with different timed artificial insemination (TAI protocols on the pregnancy rate (PR in Bos indicus cows previously treated with progesterone. Five hundred and fifty-seven primiparous cows were subjected to the following treatments: on day 0 (d0, GeCGTW (group equine Chorionic Gonadotropin+Temporary Weaning;n=178 received 0,558 g intravaginal progesterone (P4+1.0 mg of estradiol benzoate (EB (IM; on d8 (P4 removal+0,075 mg D-cloprostenol + 400 IU eCG + TW for 48 h; on d10, TAI + calves return to dam; GeCGEB (group equine Chorionic Gonadotropin+Estradiol benzoate; n=176 the same as GeCGTW without TW + application of 1.0 mg of EB on d9; GeCGEC (group equine Chorionic Gonadotropin+Estradiol Cypionate; n=203, the same as GeCGTW without TW+1.5 mg EC (IM. On d35, post TAI, pregnancy diagnosis (PD was performed. Non-pregnant animals remained under clean-up bulls for 90 days. After this period, the animals were subjected to PD using ultrasound. The PR of TAI was 51.1%, 47.1%, and 47.8% for GeCGTW, GeCGEB24, and GeCGEC (P>0.05 respectively. The PR under clean-up bulls was 88.3%, 47.3%, and 31.1% (P<0.05. The final PR (TAI+clean-up bulls of the groups was 94.4%, 72.1%, and 64.0%, respectively (P<0.05. It was concluded that no differences in PR among the protocols related to TAI were detected; PR in the GeCGTW protocol under clean-up bulls was higher compared to others (P<0.05; the overall PR of cows subjected to TAI+clean-up bulls was significantly higher in GeCGTW than in the other groups.

  3. Antifungal Activity of Diglycerin Ester of Fatty Acids against Yeasts and Its Comparison with Those of Sucrose Monopalmitate and Sodium Benzoate.

    Science.gov (United States)

    Shimazaki, Aiko; Sakamoto, Jin J; Furuta, Masakazu; Tsuchido, Tetsuaki

    2016-01-01

    The antifungal activities of diglycerin monoester of fatty acids (DGCs), which have been employed as food emulsifiers, were examined against three yeasts, Saccharomyces cerevisiae, Candida albicans and Candida utilis and were compared with those of sucrose monoester of palmitic acid (SC16) as another type of emulsifier and sodium benzoate (SB) as a weak acid food preservative. When the minimum growth inhibitory concentrations (MICs) of diglycerin monolaurate (DGC12) against these yeasts were determined 2 d after incubation in YM broth at pH5.0, they were relatively low, being 0.01% (w/v), for both S. cerevisiae and C. utilis, whereas was high, being 4.0% (w/v), for C. albicans. On the contrary, the MICs of sucrose monopalmitate (SC16) were high, being 3.0 and 4.0% (w/v), for the former two yeasts, respectively, but 0.6% (w/v) for the last yeast. In contrast to these emulsifiers, the MICs of sodium benzoate (SB) were similar independently upon the yeast strain, being in order 0.4, 0.3 and 0.5% (w/v), for the above yeasts, respectively. The anti-yeast activities of DGC12 and SC16 were gradually increased with a decrease in pH, in a manner similar to that of SB, except for the action of SC16 on C. albicans, for which the activity was more effective at pHs 5.0 and 6.0 than at pHs 4.0 and 7.0. Among DGCs tested having different fatty acid moieties in the molecule, lauroyl ester (DGC12) was more effective than myristoyl and palmitoyl esters against S. cerevisiae and C. utilis. The inhibitory effect of DGC12 on the yeast growth depended upon both the cell density and the strength of aeration during the treatment. Further, DGC12 was found to kill S. cerevisiae and C. utilis cells at a rather low concentration of 0.005% (w/v) in 50mM acetate buffer at pH5.0, although, against C. albicans cells, only slight fungicidal activity was demonstrated at a high concentration of 0.5% (w/v). The results obtained support the effectiveness of practical application of DGC12 to acidic

  4. 苯甲酸钠对草履虫的毒性作用研究%Research on the Toxicity of Sodium Benzoate against Paramecium

    Institute of Scientific and Technical Information of China (English)

    刘俊; 李霖; 张晓燕

    2011-01-01

    The acute and chronic toxicity of sodium benzoate (SB) against paramecium was studied in this article. The one-hour acute toxicity experiment showed that the higher SB concentration was, the greater was the toxic effect. LC50 was 14.14g·L^-1 while the maximum totally-lethal concentration and minimum lethal con-centration was 19g·L^-1 and 8g·L^-1, respectively. The chronic toxicity experiment indicated that there existed significant dose-response-effect as well as time-response effect between the population growth rate and SB concentration. When the SB concentration was less than the minimum lethal concentration, an increased population growth rate was observed with the higher SB concentration when treated with a certain range of SB con- centration within a certain time. This promotion effect of sodium benzoate on the reproduction of paramecium might be due to the effect of environmental estrogens.%本文研究了苯甲酸钠对草履虫的急性和慢性毒性作用。结果表明:1h急性毒性实验显示,浓度越大,死亡率越高。1h急性毒性作用LC50为14.14g·L^-1,绝对致死剂量为19g·L^-1,最小致死剂量为8g·L^-1。慢性毒性实验显示,种群增长率与苯甲酸钠浓度间具有显著的反应-剂量效应和反应-时间效应,在小于绝对致死剂量情况下,一定时间、一定浓度范围内呈现出浓度越大,种群增长率越高的现象。苯甲酸钠对草履虫生殖的促进作用有可能是环境雌激素的效应。

  5. 甲维盐与苏云金杆菌复配对黄野螟增效作用研究%Studies on the Synergistic Effects of Emamectin--benzoate and Bacillus thuringiensis on Heortia vitessoides Moore

    Institute of Scientific and Technical Information of China (English)

    王玲; 郑礼飞; 陈志云; 李东文; 曹春雷; 李奕震

    2012-01-01

    The synergistic effects of Emamectin--benzoate, Bacillus thuringiensis, and their mixtures on Heortza wtessoides were tested in the laboratory by the leaf--dipping method. The results showed that the LC50 of Emamectin--benzoate and Bacillus thuringiensis were 0. 0000001286mg/L and 0. 0006943385mg/L, respectively. The mixture of Emamectin--benzoate and Bacillus thuringiensis with ratio of 8 : 2, 7 : 3 or 6:4 had remarkable synergistic effects.%采用浸叶法测定了两种农药对黄野螟的增效作用及两种药剂复配的适宜配比。结果表明:甲维盐和苏云金杆菌对黄野螟的制剂LC50值分别是0.0000001286mg/L和0.0006943385mg/L,前者毒力大于后者;两者以重量比为8∶2、7:3和6:4混配时的增效作用最明显。

  6. Vibration Characteristics of Hydrodynamic Fluid Film Pocket Journal Bearings

    Directory of Open Access Journals (Sweden)

    N. S. Feng

    2010-01-01

    Full Text Available Theoretical analyses of hydrodynamic fluid film bearings with different bearing profiles rely on solutions of the Reynolds equation. This paper presents an approach used for analysing the so-called pocket bearings formed from a combination of offset circular bearing profiles. The results show that the variation of the dynamic bearing characteristics with different load inclinations for the pocket bearings is less than that for the elliptic bearing counterpart. It is shown that the natural frequencies as well as the critical speeds, and hence the vibrational behaviour, can also be significantly different for an industrial rotor supported by the different bearings.

  7. North Cascades Grizzly Bear Ecosystem Evaluation

    Data.gov (United States)

    Oak Ridge National Laboratory — We conducted a 6-year evaluation of the North Cascades Grizzly Bear Ecosystem (NCGBE) in north-central Washington to determine the suitability of the area to support...

  8. Polar bear research in Alaska, spring 1982

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — An investigation of the ecology and population dynamics of Alaskan polar bears has continued since 1967. As part of that program, U.S. Fish and Wildlife Service...

  9. Telemetry techniques used on Kodiak brown bear

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes the results of a study on the techniques used to monitor the movements of Kodiak brown bears instrumented with radio transmitters. Methods...

  10. Mercury biomagnification in polar bears ( Ursus maritimus)

    Science.gov (United States)

    Horton, T. W.; Blum, J. D.; Xie, Z.; Hren, M.; Chamberlain, C. P.

    2007-12-01

    Mercury biomagnification occurs in a variety of ecosystems resulting in greater potential for toxicological effects in higher-level trophic feeders. However, Hg transport pathways through different foodweb channels are not well known, particularly in high-latitude systems affected by atmospheric Hg deposition associated with snow and ice. Stable carbon and nitrogen isotope ratios and Hg concentrations determined for 26 late 19th and early 20th century polar bear hair specimens collected from cataloged museum collections elucidate relationships between high latitude marine foodweb structure and Hg transport pathways. Nitrogen and carbon isotopic compositions suggest that polar bears derive nutrition from both open water (pelagic) and ice associated (sympagic) foodweb channels. Correlation between Hg concentrations and nitrogen isotope compositions indicate mercury biomagnification occurred in most of the polar bears investigated. Interpretation of stable isotope based foodweb structure in concert with Hg concentrations further suggests that Hg biomagnification occurred to a greater degree in polar bears participating in pelagic foodweb channels.

  11. Bear Lake-Minidoka - Phragmites Control

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Bear Lake: Phragmites patches were sprayed on the refuge & north of the lake proper. Minidoka: patches along the Snake River & Lake Walcott were treated with...

  12. Polar bear research in Alaska, spring 1981

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — An investigation of the ecology and population dynamics of Alaskan polar bears has continued since 1967. As part of that program, U.S. Fish and Wildlife Service...

  13. AX-5 space suit bearing torque investigation

    Science.gov (United States)

    Loewenthal, Stuart; Vykukal, Vic; Mackendrick, Robert; Culbertson, Philip, Jr.

    1990-01-01

    The symptoms and eventual resolution of a torque increase problem occurring with ball bearings in the joints of the AX-5 space suit are described. Starting torques that rose 5 to 10 times initial levels were observed in crew evaluation tests of the suit in a zero-g water tank. This bearing problem was identified as a blocking torque anomaly, observed previously in oscillatory gimbal bearings. A large matrix of lubricants, ball separator designs and materials were evaluated. None of these combinations showed sufficient tolerance to lubricant washout when repeatedly cycled in water. The problem was resolved by retrofitting a pressure compensated, water exclusion seal to the outboard side of the bearing cavity. The symptoms and possible remedies to blocking are discussed.

  14. Cavitation Peening of Aerospace Bearings Project

    Data.gov (United States)

    National Aeronautics and Space Administration — High-value bearings are a critical part of the safety, reliability, cost and performance of modern aircraft. A typical passenger jet will have 100 to 175 high-valve...

  15. The polar bear and its protection

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — No census has been made of the polar bear population and indeed the general movements of the animals within their range are poorly known. At present it is not...

  16. LIGHT-WEIGHT LOAD-BEARING STRUCTURE

    DEFF Research Database (Denmark)

    2009-01-01

    The invention relates to a light-weight load-bearing structure (1) with optimized compression zone (2), where along one or more compression zones (2) in the structure (1) to be cast a core (3) of strong concrete is provided, which core (3) is surrounded by concrete of less strength (4) compared...... to the core (3) of strong concrete. The invention also relates to a method of casting of light-weight load-bearing structures (1) with optimized compression zone (2) where one or more channels, grooves, ducts, pipes and/or hoses (5) formed in the load-bearing structure (1) serves as moulds for moulding one...... or more cores (3) of strong concrete in the light-weight load-bearing structure (1)....

  17. Active Magnetic Bearings – Magnetic Forces

    DEFF Research Database (Denmark)

    Kjølhede, Klaus

    2006-01-01

    Parameter identification procedures and model validation are major steps towards intelligent machines supported by active magnetic bearings (AMB). The ability of measuring the electromagnetic bearing forces, or deriving them from measuring the magnetic flux, strongly contributes to the model...... validation and leads to novel approaches in identifying crucial rotor parameters. This is the main focus of this paper, where an intelligent AMB is being developed with the aim of aiding the accurate identification of damping and stiffness coefficients of journal bearings and seals. The main contribution...... of the magnetic forces are led by using different experimental tests: (I) by using hall sensors mounted directly on the poles (precise measurements of the magnetic flux) and by an auxiliary system, composed of strain gages and flexible beams attached to the rotor; (II) by measuring the input current and bearing...

  18. Novel nano bearings constructed by physical adsorption

    Science.gov (United States)

    Zhang, Yongbin

    2015-09-01

    The paper proposes a novel nano bearing formed by the physical adsorption of the confined fluid to the solid wall. The bearing is formed between two parallel smooth solid plane walls sliding against one another, where conventional hydrodynamic lubrication theory predicted no lubricating effect. In this bearing, the stationary solid wall is divided into two subzones which respectively have different interaction strengths with the lubricating fluid. It leads to different physical adsorption and slip properties of the lubricating fluid at the stationary solid wall respectively in these two subzones. It was found that a significant load-carrying capacity of the bearing can be generated for low lubricating film thicknesses, because of the strong physical adsorption and non-continuum effects of the lubricating film.

  19. Active magnetic bearings used as exciters for rolling element bearing outer race defect diagnosis.

    Science.gov (United States)

    Xu, Yuanping; Di, Long; Zhou, Jin; Jin, Chaowu; Guo, Qintao

    2016-03-01

    The active health monitoring of rotordynamic systems in the presence of bearing outer race defect is considered in this paper. The shaft is assumed to be supported by conventional mechanical bearings and an active magnetic bearing (AMB) is used in the mid of the shaft location as an exciter to apply electromagnetic force to the system. We investigate a nonlinear bearing-pedestal system model with the outer race defect under the electromagnetic force. The nonlinear differential equations are integrated using the fourth-order Runge-Kutta algorithm. The simulation and experimental results show that the characteristic signal of outer race incipient defect is significantly amplified under the electromagnetic force through the AMBs, which is helpful to improve the diagnosis accuracy of rolling element bearing׳s incipient outer race defect.

  20. Effects of fluid inertia and bearing flexibility on the performance of finite length journal bearing

    Science.gov (United States)

    Javorova, Juliana; Alexandrov, Vassil

    2017-02-01

    The paper describes the theoretical study concerning the effect of lubricant inertia forces and deformability of the bearing elastic layer on the performance of a plane journal bearing. The problem is investigated for a Newtonian lubricant under isothermal and isoviscous conditions. The analysis considers the generalized Reynolds equation governing the flow of lubricant in the clearance space and the linear elasticity equation governing the displacement field in the bearing shell. An iterative numerical procedure with successive over relaxation is used to pressure distribution within the lubricated conjunction. Bearing performance characteristics have been presented for typically selected values of generalized Reynolds number Re* and elasticity parameters of the elastic liner. It has been observed that the combined effect of fluid inertia forces and bearing flexibility affects the performance characteristics of dynamically loaded journal bearing.

  1. Passive magnetic bearings for vehicular electromechanical batteries

    Energy Technology Data Exchange (ETDEWEB)

    Post, R

    1996-03-01

    This report describes the design of a passive magnetic bearing system to be used in electromechanical batteries (flywheel energy storage modules) suitable for vehicular use. One or two such EMB modules might, for example, be employed in a hybrid-electric automobile, providing efficient means for power peaking, i.e., for handling acceleration and regenerative braking power demands at high power levels. The bearing design described herein will be based on a ''dual-mode'' operating regime.

  2. Silicon Nitride Balls For Cryogenic Bearings

    Science.gov (United States)

    Butner, Myles F.; Ng, Lillian W.

    1990-01-01

    Resistance to wear greater than that of 440C steel. Experiments show lives of ball bearings immersed in liquid nitrogen or liquid oxygen increased significantly when 440C steel balls (running on 440C steel races) replaced by balls of silicon nitride. Developed for use at high temperatures, where lubrication poor or nonexistent. Best wear life of any bearing tested to date and ball material spalls without fracturing. Plans for future tests call for use of liquid oxygen as working fluid.

  3. Flywheel energy storage with superconductor magnetic bearings

    Energy Technology Data Exchange (ETDEWEB)

    Weinberger, Bernard R. (Avon, CT); Lynds, Jr., Lahmer (Glastonbury, CT); Hull, John R. (Hinsdale, IL)

    1993-01-01

    A flywheel having superconductor bearings has a lower drag to lift ratio that translates to an improvement of a factor of ten in the rotational decay rate. The lower drag results from the lower dissipation of melt-processed YBCO, improved uniformity of the permanent magnet portion of the bearings, operation in a different range of vacuum pressure from that taught by the art, and greater separation distance from the rotating members of conductive materials.

  4. Active magnetic bearings for optimum turbomachinery design

    Science.gov (United States)

    Hustak, J.; Kirk, R. G.; Schoeneck, K. A.

    1985-01-01

    The design and shop test results are given for a high speed eight stage centrifugal compressor supported by active magnetic bearings. A brief summary of the rotor dynamics analysis is presented with specific attention given to design considerations for optimum rotor stability. The concerns for retrofit of magnetic bearings in existing machinery are discussed with supporting analysis of a four stage centrifugal compressor. Recommendations are given on design and analysis requirements for successful machinery operation of either retrofit or new design turbomachinery.

  5. Rotordynamics and bearing design of turbochargers

    Science.gov (United States)

    Chen, Wen Jeng

    2012-05-01

    Turbochargers have gained significant attention in recent years. They are already widely used in automotive, locomotive, and marine applications with diesel engines. They are also applied in the aerospace application to increase the engine performance now. The turbochargers used in automotive and aerospace industry are very light-weight with operating speeds above 100,000 rpm. The turbochargers used in locomotive and marine applications are relatively heavy in size and power compared to the automotive and aerospace applications, and the maximum continuous operating speeds are around 30,000 rpm depending on the diesel engine power rating. Floating ring bushings, semi-floating dampers, ball bearings, and ball bearings with dampers are commonly used in automotive applications for small turbochargers. However, these bearings may not be appropriate for large turbochargers in locomotive and marine applications. Instead, multi-lobed bearings with and without squeeze film dampers are commonly used in these heavy-duty turbochargers. This paper deals with the rotordynamic characteristics of larger turbochargers in locomotive and marine applications. Various bearing designs are discussed. Bearing design parameters are studied and optimal values are suggested. Test results are also presented to support the analytical simulation.

  6. Bearing and gear steels for aerospace applications

    Science.gov (United States)

    Zaretsky, Erwin V.

    1990-01-01

    Research in metallurgy and processing for bearing and gear steels has resulted in improvements in rolling-element bearing and gear life for aerospace application by a factor of approximately 200 over that obtained in the early 1940's. The selection and specification of a bearing or gear steel is dependent on the integration of multiple metallurgical and physical variables. For most aerospace bearings, through-hardened VIM-VAR AISI M-50 steel is the material of preference. For gears, the preferential material is case-carburized VAR AISI 9310. However, the VAR processing for this material is being replaced by VIM-VAR processing. Since case-carburized VIM-VAR M-50NiL incorporates the desirable qualities of both the AISI M-50 and AISI 9310 materials, optimal life and reliability can be achieved in both bearings and gears with a single steel. Hence, this material offers the promise of a common steel for both bearings and gears for future aerospace applications.

  7. 苯甲酸降解途径及转化生产粘康酸的研究进展%Research Progress in Benzoate Degradation Pathways and Transformation for cis,cis-Muconic Acid

    Institute of Scientific and Technical Information of China (English)

    谢能中; 黄艳燕; 李检秀; 郭铃; 李亿; 王青艳; 陈东; 杜奇石; 黄日波

    2014-01-01

    苯甲酸是多种芳香化合物生物代谢的重要中间物,对微生物降解苯甲酸的生物化学和遗传学研究,有利于阐明芳香化合物的生物降解机制,分离和培育出降解谱广和降解性能高的菌株应用于废水处理、环境修复和生物转化。苯甲酸的儿茶酚邻位裂解(ortho-cleavage)途径会产生粘康酸,后者是一种潜在的平台化合物,用于生产新型功能树脂、生物塑料、食品添加剂等产品。本文综述了微生物降解苯甲酸和转化生产粘康酸的研究和进展,并提出该领域研究今后的发展方向,为后续研究提供有价值的参考。%Benzoate is a model aromatic compound,which is also an important intermediate of a variety of aromatic compounds. Studying microbial degradation of benzoate provides knowledge on the metabolic mechanism of other aromatic compounds,facilitates the screen of efficient bacteria for wastewater treatment,environmental remediation and biotransforma-tion.Benzoate can be metabolized via catechol by means of the ortho-cleavage pathway to yield cis,cis-muconic acid,which is suggested to be an interesting platform chemical for the pro-duction of new functional resins,bio-plastics and food additives.In this paper,various benzoate degradation pathways and cis,cis-muconic acid production by biotransformation of benzoate are reviewed, and guidelines for developing high performance microbial cell factory for cis,cis-muconic acid production are also proposed.

  8. Metallo-porphyrazines with eight [5-thiopentyl 3,4,5-tris(benzyloxy)benzoate] groups: Synthesis, characterization, aggregation, and solubility behavior

    Science.gov (United States)

    Gonca, Ergün

    2017-02-01

    Metal-free and metallo-porphyrazines having eight 5-hydroxypentylthio units at the peripheral positions have been prepared from 2,3-bis(5-hydroxypentylthio)maleonitrile. By the esterification reaction of magnesium hydroxy-porphyrazine with 3,4,5-tris(benzyloxy)benzoic acid in dicyclohexylcarbodiimide and toluene-p-sulfonic acid, the reactivity of the hydroxypentyl units was indicated. On the other hand, iron porphyrazine derivatives with eight [5-thiopentyl 3,4,5-tris(benzyloxy)benzoate] groups attached to the periphery positions were synthesized. By the reaction of metal-free porphyrazine with iron (II) acetate and further processing with HCl solution, FePzCl was obtained. Finally, by reacting FePzCl with pyridine or pyrazine, [FePz(py)2] and [FePz(pyz)]n complexes were prepared, respectively. The characterizations of target complexes were carried out by utilizing different spectroscopic methods such as FT-IR, UV-vis, mass, 1H NMR, and 13C NMR together with elemental analysis.

  9. Crystal structures of (E-4-[1-(2-carbamothioylhydrazinylideneethyl]phenyl acetate and (E-4-[1-(2-carbamothioylhydrazinylideneethyl]phenyl benzoate

    Directory of Open Access Journals (Sweden)

    Vijayan Viswanathan

    2017-01-01

    Full Text Available In the title compounds, C11H13N3O2S, (I, and C16H15N3O2S, (II, the thiosemicarbazone group adopts an extended conformation. The acetate ester (I crystallizes with two independent molecules in the asymmetric unit. In the benzoate ester (II, the planes of the two aryl rings are inclined to one another by 46.70 (7°. In both compounds, there is a short intramolecular N—H...N contact present, forming an S(5 ring motif. In the crystals of both compounds, molecules are linked via pairs of N—H...S hydrogen bonds, forming dimers with R22(8 ring motifs. The dimers are linked by N—H...S and N—H...O hydrogen bonds, forming slabs parallel to (01-1. In (I, there are N—H...π and C—H...π interactions present within the slabs, while in (II, there are only N—H...π interactions present.

  10. Study of the photochemical transformation of 2-ethylhexyl 4-(dimethylamino)benzoate (OD-PABA) under conditions relevant to surface waters.

    Science.gov (United States)

    Calza, P; Vione, D; Galli, F; Fabbri, D; Dal Bello, F; Medana, C

    2016-01-01

    We studied the aquatic environmental fate of 2-ethylhexyl 4-(dimethylamino)benzoate (OD-PABA), a widespread sunscreen, to assess its environmental persistence and photoinduced transformation. Direct photolysis is shown to play a key role in phototransformation, and this fast process is expected to be the main attenuation route of OD-PABA in sunlit surface waters. The generation of transformation products (TPs) was followed via HPLC/HRMS. Five (or four) TPs were detected in the samples exposed to UVB (or UVA) radiation, respectively. The main detected TPs of OD-PABA, at least as far as HPLC-HRMS peak areas are concerned, would involve a dealkylation or hydroxylation/oxidation process in both direct photolysis and indirect phototransformation. The latter was simulated by using TiO2-based heterogeneous photocatalysis, involving the formation of nine additional TPs. Most of them resulted from the further degradation of the primary TPs that can also be formed by direct photolysis. Therefore, these secondary TPs might also occur as later transformation intermediates in natural aquatic systems.

  11. Self-assembly and UV-curing Property of Polymerized Lyotropic Liquid Crystal Monomer of Sodium 3,4,5-tris(11-acryloxyundecyloxy)benzoate

    Institute of Scientific and Technical Information of China (English)

    Yu-qin Bai; Jin-bao Guo; Ying Wang; Jie Wei

    2013-01-01

    A polymerized lyotropic liquid crystal monomer of sodium 3,4,5-tris (11-acryloxyundecyloxy)benzoate was synthesized by a convenient route starting from 3,4,5-trihydroxybenzoic acid via esterification followed by etherification,acylation and finally neutralization.The chemical structure was confirmed by Fourier transform infrared (FT-IR) and 1H nuclear magnetic resonance spectral analysis.The self-organization behavior of the monomer with deionized water in methanol at room temperature was also demonstrated.The assemblies were characterized by polarized optical microscope and X-ray diffraction.The results show that a solution containing 80∶20 of the monomer to water was found to be able to self-organize into Lamellar (La) phase and 92∶8 with inverted hexagonal (HⅡ) phase,which was in accordance with the theoretical calculation of critical packing parameter.It suggests that the concentration of the monomer was the key factor to influence assembly structure.Additionally,the acrylate conversion with different photoinitiators and nanostructure retention after polymerization were investigated.The research shows that the acrylate conversion of the monomer with Darocur2959 could reach up to 78% when irradiated by 30 mW/cm2 UV light of 365 nm for 30 min characterized by Real-time FT-IR as well as the sol-gel method.Meanwhile,the La and HⅡI phase nanostructures were both retained after polymerization.

  12. An electrochemical sensor for rizatriptan benzoate determination using Fe3O4 nanoparticle/multiwall carbon nanotube-modified glassy carbon electrode in real samples.

    Science.gov (United States)

    Madrakian, Tayyebeh; Maleki, Somayeh; Heidari, Mozhgan; Afkhami, Abbas

    2016-06-01

    In this paper a sensitive and selective electrochemical sensor for determination of rizatriptan benzoate (RZB) was proposed. A glassy carbon electrode was modified with nanocomposite of multiwalled carbon nanotubes (MWCNTs) and Fe3O4 nanoparticles (Fe3O4/MWCNTs/GCE). The results obtained clearly show that the combination of MWCNTs and Fe3O4 nanoparticles definitely improves the sensitivity of modified electrode to RZB determination. The morphology and electroanalytical performance of the fabricated sensor were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDS), square wave voltammetry (SWV) and cyclic voltammetry (CV). Also, the effect of experimental and instrumental parameters on the sensor response was evaluated. The square wave voltammetric response of the electrode to RZB was linear in the range 0.5-100.0 μmol L(-1) with a detection limit of 0.09 μmol L(-1) under the optimum conditions. The investigated method showed good stability, reproducibility and repeatability. The proposed sensor was successfully applied for real life samples of blood serum and RZB determination in pharmaceutical.

  13. Ferrous-salt-promoted damage to deoxyribose and benzoate. The increased effectiveness of hydroxyl-radical scavengers in the presence of EDTA.

    Science.gov (United States)

    Gutteridge, J M

    1987-05-01

    Hydroxyl radicals (OH.) in free solution react with scavengers at rates predictable from their known second-order rate constants. However, when OH. radicals are produced in biological systems by metal-ion-dependent Fenton-type reactions scavengers do not always appear to conform to these established rate constants. The detector molecules deoxyribose and benzoate were used to study damage by OH. involving a hydrogen-abstraction reaction and an aromatic hydroxylation. In the presence of EDTA the rate constant for the reaction of scavengers with OH. was generally higher than in the absence of EDTA. This radiomimetic effect of EDTA can be explained by the removal of iron from the detector molecule, where it brings about a site-specific reaction, by EDTA allowing more OH. radicals to escape into free solution to react with added scavengers. The deoxyribose assay, although chemically complex, in the presence of EDTA appears to give a simple and cheap method of obtaining rate constants for OH. reactions that compare well with those obtained by using pulse radiolysis.

  14. Food additives: Sodium benzoate, potassium sorbate, azorubine, and tartrazine modify the expression of NFκB, GADD45α, and MAPK8 genes.

    Science.gov (United States)

    Raposa, B; Pónusz, R; Gerencsér, G; Budán, F; Gyöngyi, Z; Tibold, A; Hegyi, D; Kiss, I; Koller, Á; Varjas, T

    2016-09-01

    It has been reported that some of the food additives may cause sensitization, inflammation of tissues, and potentially risk factors in the development of several chronic diseases. Thus, we hypothesized that expressions of common inflammatory molecules - known to be involved in the development of various inflammatory conditions and cancers - are affected by these food additives. We investigated the effects of commonly used food preservatives and artificial food colorants based on the expressions of NFκB, GADD45α, and MAPK8 (JNK1) from the tissues of liver. RNA was isolated based on Trizol protocol and the activation levels were compared between the treated and the control groups. Tartrazine alone could elicit effects on the expressions of NFκB (p = 0.013) and MAPK8 (p = 0.022). Azorubine also resulted in apoptosis according to MAPK8 expression (p = 0.009). Preservatives were anti-apoptotic in high dose. Sodium benzoate (from low to high doses) dose-dependently silenced MAPK8 expression (p = 0.004 to p = 0.002). Addition of the two preservatives together elicited significantly greater expression of MAPK8 at half-fold dose (p = 0.002) and at fivefold dose (p = 0.008). This study suggests that some of the food preservatives and colorants can contribute to the activation of inflammatory pathways.

  15. Toughening of Epoxy Resin with Solid Amine Terminated Poly (ethy-lene glycol) Benzoate and Effect of Red Mud Waste Particles

    Institute of Scientific and Technical Information of China (English)

    B.C.Samanta; T.Maity; S.Dalai; A.K.Banthia

    2008-01-01

    An investigation was carried out to modify the toughness of triethylene tetramine cured DGEBA (diglycidyl ether of bisphenol-A) resin using solid amine terminated poly (ethylene glycol) benzoate (ATPEGB) as modifier with and without red mud waste particles. The solid ATPEGB modifier synthesized from the acid catalyzed esterification reaction of poly (ethylene glycol) (PEG) and 4-amino benzoic acid was characterized by Fourier transform infrared spectroscopy (FT-IR) and 1H-NMR (nuclear magnetic resonance) spectroscopies, viscosity measurements, and solubility parameter calculation. The unfilled and red mud waste filled modified epoxy networks were evaluated with impact, adhesive, tensile, flexural and thermal properties by differential scanning calorimetry (DSC), thermogravimetric (TG) and dynamic mechanical analysis (DMA). The effect of modifier concentration and red mud waste particles on toughening behavior was also investigated. The optimum properties were obtained at 12.5 phr (parts per hundred parts of resin) concentration of the modifier. The ATPEGB modified cured epoxy was thermally stable up to 315℃. The morphology on fracture surfaces of cured epoxy was also analyzed by scanning electron microscopy (SEM).

  16. Phase transition from focal conic to cubic smectic blue phase in partially fluorinated cyano-phenyl alkyl benzoate ester doped with ultrahigh twisting power chiral dopant

    CERN Document Server

    Nayek, Prasenjit; Li, Guoqiang

    2015-01-01

    Blue phase liquid crystal (BPLC) has important applications in adaptive lenses and phase modulators due to its polarization-independent property. During our efforts for development of the new materials, we found a novel phenomenology of phase transition, from focal conic smectic to smectic blue phase in a partially fluorinated cyanophenyl alkyl benzoate ester based nematic liquid crystal (LCM-5773) doped by ultra-high twisting power [H.T.P~160 um^-1] chiral dopant (R5011/3 wt%). Polarized optical microscopy (POM) investigations revealed focal conic and fan-shaped textures typical for columnar mesophases. These focal conic domains (FCDs) are squeezed under electric field and finally at a critical electric field they undergo a dark state. When the electric field is withdrawn, the FCDs are regrown in a one dimensional array with smaller domain size. Interestingly, we have observed the domain size of the FCDs can grow several times by decreasing the cooling rate (0.02 degrees(C)/min.) ten times without any change...

  17. The Gibbs free energy of formation of halogenated benzenes, benzoates and phenols and their potential role as electron acceptors in anaerobic environments.

    Science.gov (United States)

    Dolfing, Jan; Novak, Igor

    2015-02-01

    The sequence of redox reactions in the natural environment generally follows the electron affinity of the electron acceptors present and can be rationalized by the redox potentials of the appropriate half-reactions. Answering the question how halogenated aromatics fit into this sequence requires information on their Gibbs free energy of formation values. In 1992 Gibbs free energy data for various classes of halogenated aromatic compounds were systematically explored for the first time based on Benson's group contribution method. Since then more accurate quantum chemical calculation methods have become available. Here we use these methods to estimate enthalpy and Gibbs free energy of formation values of all chlorinated and brominated phenols. These data and similar state-of-the-art datasets for halogenated benzenes and benzoates were then used to calculate two-electron redox potentials of halogenated aromatics for standard conditions and for pH 7. The results underline the need to take speciation into consideration when evaluating redox potentials at pH 7 and highlight the fact that halogenated aromatics are excellent electron acceptors in aqueous environments.

  18. Transient Vibration Prediction for Rotors on Ball Bearings Using Load-dependent Non-linear Bearing Stiffness

    Science.gov (United States)

    Fleming, David P.; Poplawski, J. V.

    2002-01-01

    Rolling-element bearing forces vary nonlinearly with bearing deflection. Thus an accurate rotordynamic transient analysis requires bearing forces to be determined at each step of the transient solution. Analyses have been carried out to show the effect of accurate bearing transient forces (accounting for non-linear speed and load dependent bearing stiffness) as compared to conventional use of average rolling-element bearing stiffness. Bearing forces were calculated by COBRA-AHS (Computer Optimized Ball and Roller Bearing Analysis - Advanced High Speed) and supplied to the rotordynamics code ARDS (Analysis of Rotor Dynamic Systems) for accurate simulation of rotor transient behavior. COBRA-AHS is a fast-running 5 degree-of-freedom computer code able to calculate high speed rolling-element bearing load-displacement data for radial and angular contact ball bearings and also for cylindrical and tapered roller beatings. Results show that use of nonlinear bearing characteristics is essential for accurate prediction of rotordynamic behavior.

  19. Polar bears: the fate of an icon.

    Science.gov (United States)

    Fitzgerald, Kevin T

    2013-11-01

    Polar bears are one of the most iconic animals on our planet. Worldwide, even people who would never see one are drawn to these charismatic arctic ice hunters. They are the world's largest terrestrial carnivore, and despite being born on land, they spend most of their lives out on the sea ice and are considered a marine mammal. Current global studies estimate there are around 20,000 animals in some 19 discrete circumpolar populations. Aside from pregnant females denning in the winter months to give birth, the white bears do not hibernate. They spend their winters on the sea ice hunting seals, an activity they are spectacularly adapted for. Research on these animals is incredibly difficult because of the inhospitable surroundings they inhabit and how inaccessible they make the bears. For many years, the sum of our understanding of the natural history of polar bears came from tracks, scats, the remains of their kills, abandoned dens, and anecdotal observations of native hunters, explorers, and early biologists. Nonetheless, the last 40 years have seen a much better picture of their biology emerge thanks to, first, dedicated Canadian researchers and, later, truly international efforts of workers from many countries. Veterinarians have contributed to our knowledge of the bears by delivering and monitoring anesthesia, obtaining blood samples, performing necropsies, investigating their reproduction, conducting radiotelemetry studies, and examining their behavior. Recently, new technologies have been developed that revolutionize the study of the lives and natural history of undisturbed polar bears. These advances include better satellite radiotelemetry equipment and the development of remote-controlled miniature devices equipped with high-definition cameras. Such new modalities provide dramatic new insights into the life of polar bears. The remarkable degree of specialized adaptation to life on the sea ice that allowed the bears to be successful is the very reason that

  20. Wear numbers for ball cup and journal bearings

    NARCIS (Netherlands)

    Ligterink, D.J.; Moes, H.

    1980-01-01

    A wear number is defined for ball cup bearings and for journal bearings where the cup and the cylindrical bearing are made of soft material. This dimensionless wear number provides a relation between the following five quantities: the radius of the ball or the length of the journal bearing in millim

  1. 49 CFR 230.102 - Tender plain bearing journal boxes.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Tender plain bearing journal boxes. 230.102... Locomotives and Tenders Running Gear § 230.102 Tender plain bearing journal boxes. Plain bearing journal boxes... expected to damage the bearing; or have a detrimental effect on the lubrication of the journal and...

  2. Nonlinear vibrations and stability of aerostatic bearing

    Directory of Open Access Journals (Sweden)

    Kozánek J.

    2008-12-01

    Full Text Available Bearings based on aerostatic principle belong to the new machine elements advantageous for low- and high-speed applications, but their dynamic and stability properties are not yet sufficiently known. This paper presents a new elaborated method and gained results of theoretical investigation of dynamic properties of aerostatic bearing in general dimensionless form. It is aimed also as a supporting tool for diagnostic and identification methods used at developing of new bearings proposed by TECHLAB, Prague for industrial applications. Mathematical model expresses nonlinear and evolutive properties in the entire area of bearing clearance, contains sufficient number of free parameters in functions of restoring and damping forces and can therefore describe all types of motions occurring in gas bearings as periodic, quasi-periodic, including beats and instability, which can leads to chaotic and self-excited vibrations. The influence of non-diagonal elements of stiffness and damping matrices of linearized model on the spectral properties and the stability of system is investigated, too.

  3. Oxford phase III meniscal bearing fracture: case report.

    Science.gov (United States)

    Lim, Hong-Chul; Shon, Won-Yong; Kim, Seung-Ju; Bae, Ji-Hoon

    2014-01-01

    Meniscal bearing fracture is a rare complication of phase III Oxford unicompartmental knee replacement (UKR). We report a case of a meniscal bearing fracture that occurred 7 years after phase III Oxford medial UKR. The meniscal bearing showed uneven delamination of the polyethylene in the thinnest articular surface and an impingement lesion. This lesion initiated a fatigue crack that propagated to cause failure of the meniscal bearing. This is the first report of a meniscal bearing fracture without a posterior marker wire.

  4. Wear numbers for ball cup and journal bearings

    OpenAIRE

    Ligterink, D.J.; Moes, H.

    1980-01-01

    A wear number is defined for ball cup bearings and for journal bearings where the cup and the cylindrical bearing are made of soft material. This dimensionless wear number provides a relation between the following five quantities: the radius of the ball or the length of the journal bearing in millimetres, the wear modulus in newtons per square millimetre, the maximum wear depth rate of the cup or the cylindrical bearing in millimetres per second, the force between the mating surfaces in newto...

  5. Bearing tester data compilation, analysis and reporting and bearing math modeling, volume 1

    Science.gov (United States)

    Marshall, D. D.; Montgomery, E. E.; New, L. S.; Stone, M. A.; Tiller, B. K.

    1984-01-01

    Thermal and mechanical models of high speed angular contact ball bearings operating in LOX and LN2 were developed and verified with limited test data in an effort to further understand the parameters that determine or effect the SSME turbopump bearing operational characteristics and service life. The SHABERTH bearing analysis program which was adapted to evaluate shaft bearing systems in cryogenics is not capable of accommodating varying thermal properties and two phase flow. A bearing model with this capability was developed using the SINDA thermal analyzer. Iteration between the SHABERTH and the SINDA models enable the establishment of preliminary bounds for stable operation in LN2. These limits were established in terms of fluid flow, fluid inlet temperature, and axial load for a shaft speed of 30,000 RPM.

  6. Conceptual Design and Feasibility of Foil Bearings for Rotorcraft Engines: Hot Core Bearings

    Science.gov (United States)

    Howard, Samuel A.

    2007-01-01

    Recent developments in gas foil bearing technology have led to numerous advanced high-speed rotating system concepts, many of which have become either commercial products or experimental test articles. Examples include oil-free microturbines, motors, generators and turbochargers. The driving forces for integrating gas foil bearings into these high-speed systems are the benefits promised by removing the oil lubrication system. Elimination of the oil system leads to reduced emissions, increased reliability, and decreased maintenance costs. Another benefit is reduced power plant weight. For rotorcraft applications, this would be a major advantage, as every pound removed from the propulsion system results in a payload benefit.. Implementing foil gas bearings throughout a rotorcraft gas turbine engine is an important long-term goal that requires overcoming numerous technological hurdles. Adequate thrust bearing load capacity and potentially large gearbox applied radial loads are among them. However, by replacing the turbine end, or hot section, rolling element bearing with a gas foil bearing many of the above benefits can be realized. To this end, engine manufacturers are beginning to explore the possibilities of hot section gas foil bearings in propulsion engines. This overview presents a logical follow-on activity by analyzing a conceptual rotorcraft engine to determine the feasibility of a foil bearing supported core. Using a combination of rotordynamic analyses and a load capacity model, it is shown to be reasonable to consider a gas foil bearing core section. In addition, system level foil bearing testing capabilities at NASA Glenn Research Center are presented along with analysis work being conducted under NRA Cooperative Agreements.

  7. Bear bile: dilemma of traditional medicinal use and animal protection

    Directory of Open Access Journals (Sweden)

    Nagamatsu Tadashi

    2009-01-01

    Full Text Available Abstract Bear bile has been used in Traditional Chinese Medicine (TCM for thousands of years. Modern investigations showed that it has a wide range of pharmacological actions with little toxicological side effect and the pure compounds have been used for curing hepatic and biliary disorders for decades. However, extensive consumption of bear bile made bears endangered species. In the 1980's, bear farming was established in China to extract bear bile from living bears with "Free-dripping Fistula Technique". Bear farming is extremely inhumane and many bears died of illness such as chronic infections and liver cancer. Efforts are now given by non-governmental organizations, mass media and Chinese government to end bear farming ultimately. At the same time, systematic research has to be done to find an alternative for bear bile. In this review, we focused on the literature, laboratory and clinical results related to bear bile and its substitutes or alternative in English and Chinese databases. We examined the substitutes or alternative of bear bile from three aspects: pure compounds derived from bear bile, biles from other animals and herbs from TCM. We then discussed the strategy for stopping the trading of bear bile and issues of bear bile related to potential alternative candidates, existing problems in alternative research and work to be done in the future.

  8. Powder metallurgy bearings for advanced rocket engines

    Science.gov (United States)

    Fleck, J. N.; Killman, B. J.; Munson, H.E.

    1985-01-01

    Traditional ingot metallurgy was pushed to the limit for many demanding applications including antifriction bearings. New systems require corrosion resistance, better fatigue resistance, and higher toughness. With conventional processing, increasing the alloying level to achieve corrosion resistance results in a decrease in other properties such as toughness. Advanced powder metallurgy affords a viable solution to this problem. During powder manufacture, the individual particle solidifies very rapidly; as a consequence, the primary carbides are very small and uniformly distributed. When properly consolidated, this uniform structure is preserved while generating a fully dense product. Element tests including rolling contact fatigue, hot hardness, wear, fracture toughness, and corrosion resistance are underway on eleven candidate P/M bearing alloys and results are compared with those for wrought 440C steel, the current SSME bearing material. Several materials which offer the promise of a significant improvement in performance were identified.

  9. Robust Bearing Estimation for 3-Component Stations

    Energy Technology Data Exchange (ETDEWEB)

    Claassen, John P.

    1999-06-03

    A robust bearing estimation process for 3-component stations has been developed and explored. The method, called SEEC for Search, Estimate, Evaluate and Correct, intelligently exploits the in- herent information in the arrival at every step of the process to achieve near-optimal results. In particular, the approach uses a consistent framework to define the optimal time-frequency windows on which to make estimates, to make the bearing estimates themselves, to construct metrics helpful in choosing the better estimates or admitting that the bearing is immeasurable, andjinally to apply bias corrections when calibration information is available to yield a single final estimate. The method was applied to a small but challenging set of events in a seismically active region. The method demonstrated remarkable utility by providing better estimates and insights than previously available. Various monitoring implications are noted fiom these findings.

  10. Robust bearing estimation for 3-component stations

    Energy Technology Data Exchange (ETDEWEB)

    CLAASSEN,JOHN P.

    2000-02-01

    A robust bearing estimation process for 3-component stations has been developed and explored. The method, called SEEC for Search, Estimate, Evaluate and Correct, intelligently exploits the inherent information in the arrival at every step of the process to achieve near-optimal results. In particular the approach uses a consistent framework to define the optimal time-frequency windows on which to make estimates, to make the bearing estimates themselves, to construct metrics helpful in choosing the better estimates or admitting that the bearing is immeasurable, and finally to apply bias corrections when calibration information is available to yield a single final estimate. The algorithm was applied to a small but challenging set of events in a seismically active region. It demonstrated remarkable utility by providing better estimates and insights than previously available. Various monitoring implications are noted from these findings.

  11. The ultimate bearing capacity of ice beams

    Directory of Open Access Journals (Sweden)

    Li Liang

    2013-02-01

    Full Text Available It is usually proposed that bearing capacity of the ice beam during its interaction with a sloping hydraulic structure is exhausted when tensile stresses in the beam’s cross-section reach some limit. But besides the tensile stress there is a compressive stress during the interaction with a sloping structure. This can change our estimations of the ultimate bearing capacity and load exerted on the structure. The purpose of the study was to estimate influence of the longitudinal compressive stress on the ice beam’s ultimate bearing capacity. The solution was obtained with the program complex LS-DYNA. Results of the mathematical modeling were compared with data of physical experiments conducted by Sodhi. Good correlation of the results gave possibility to conduct wide numerical experiments and to suggest corrections to the existing methodology.

  12. Trace fossils in coal-bearing sequences

    Energy Technology Data Exchange (ETDEWEB)

    Pollard, J.E.

    1988-03-01

    In the past decade trace fossils have been recorded extensively from coal-bearing sediments, differing widely in facies, age and location. Westphalian or Stephanian 'coal-measures' in Britain, Europe and Eastern Canada contain an ichnofauna produced by invertebrates and/or vertebrates in upper delta plain sediments. This contrasts with the marine-related lower delta plain ichnofaunas known from Pennsylvanian rocks of the United States and Permian Gondwana 'coal-measures' of South Africa. Deltaic complexes of Middle Jurassic age in the North Sea basin and Upper Cretaceous age in North America contain marine trace fossils and dinosaur footprints in coastal coal- bearing facies. These case histories illustrate the importance of trace fossils both in facies analysis of coal-bearing sequences and in recording the presence of animals rarely known as body fossils in such clastic sediments. 80 refs., 5 figs.

  13. Demography of the Yellowstone grizzly bears

    Science.gov (United States)

    Pease, C.M.; Mattson, D.J.

    1999-01-01

    We undertook a demographic analysis of the Yellowstone grizzly bears (Ursus arctos) to identify critical environmental factors controlling grizzly bear vital rates, and thereby to help evaluate the effectiveness of past management and to identify future conservation issues. We concluded that, within the limits of uncertainty implied by the available data and our methods of data analysis, the size of the Yellowstone grizzly bear population changed little from 1975 to 1995. We found that grizzly bear mortality rates are about double in years when the whitebark pine crop fails than in mast years, and that the population probably declines when the crop fails and increases in mast years. Our model suggests that natural variation in whitebark pine crop size over the last two decades explains more of the perceived fluctuations in Yellowstone grizzly population size than do other variables. Our analysis used demographic data from 202 radio-telemetered bears followed between 1975 and 1992 and accounted for whitebark pine (Pinus albicaulis) crop failures during 1993-1995. We used a maximum likelihood method to estimate demographic parameters and used the Akaike Information Criteria to judge the significance of various independent variables. We identified no independent variables correlated with grizzly bear fecundity. In order of importance, we found that grizzly bear mortality rates are correlated with season, whitebark pine crop size (mast vs. nonmast year), sex, management-trapping status (never management-trapped vs. management-trapped once or more), and age. The mortality rate of bears that were management-trapped at least once was almost double that of bears that were never management-trapped, implying a source/sink (i.e., never management-trapped/management-trapped) structure. The rate at which bears move between the source and sink, estimated as the management-trapping rate (h), is critical to estimating the finite rate of increase, I>I?. We quantified h by

  14. STABILITY OF ROTOR-BEARING SYSTEMS

    Directory of Open Access Journals (Sweden)

    Uğur YÜCEL

    2003-03-01

    Full Text Available In various industrial applications there is a need for higher speed, yet reliably operating rotating machinery. A key factor in achieving this type of machinery continues to be the ability to accurately predict the dynamic response and stability of a rotor-bearing system. This paper introduces and explains the nature of rotordynamic phenomena from comparatively simple analytic models. Starting with the most simple rotor model that is supported in two rigid bearings at its ends, the more realistic and more involved cases are considered by incorporating the effects of flexible bearings. Knowledge of these phenomena is fundamental to an understanding of the behavior of complex models, which corresponds to the real rotors of turbomachines.

  15. Hydrolyzable polyureas bearing hindered urea bonds.

    Science.gov (United States)

    Ying, Hanze; Cheng, Jianjun

    2014-12-10

    Hydrolyzable polymers are widely used materials that have found numerous applications in biomedical, agricultural, plastic, and packaging industrials. They usually contain ester and other hydrolyzable bonds, such as anhydride, acetal, ketal, or imine, in their backbone structures. Here, we report the first design of hydrolyzable polyureas bearing dynamic hindered urea bonds (HUBs) that can reversibly dissociate to bulky amines and isocyanates, the latter of which can be further hydrolyzed by water, driving the equilibrium to facilitate the degradation of polyureas. Polyureas bearing 1-tert-butyl-1-ethylurea bonds that show high dynamicity (high bond dissociation rate), in the form of either linear polymers or cross-linked gels, can be completely degraded by water under mild conditions. Given the simplicity and low cost for the production of polyureas by simply mixing multifunctional bulky amines and isocyanates, the versatility of the structures, and the tunability of the degradation profiles of HUB-bearing polyureas, these materials are potentially of very broad applications.

  16. High Performance Magnetic Bearings for Aero Applications

    Science.gov (United States)

    Allaire, P. E.; Knospe, C. R.; Williams, R. D.; Lewis, D. W.; Barrett, L. E.; Maslen, E. H.; Humphris, R. R.

    1997-01-01

    Several previous annual reports were written and numerous papers published on the topics for this grant. That work is not repeated here in this final report. Only the work completed in the final year of the grant is presented in this final report. This final year effort concentrated on power loss measurements in magnetic bearing rotors. The effect of rotor power losses in magnetic bearings are very important for many applications. In some cases, these losses must be minimized to maximize the length of time the rotating machine can operate on a fixed energy or power supply. Examples include aircraft gas turbine engines, space devices, or energy storage flywheels. In other applications, the heating caused by the magnetic bearing must be removed. Excessive heating can be a significant problem in machines as diverse as large compressors, electric motors, textile spindles, and artificial heart pumps.

  17. Experimental investigations of active air bearings

    DEFF Research Database (Denmark)

    Santos, Ilmar; Morosi, Stefano

    2012-01-01

    Along with traditional oil lubrication, increasing demand for high-speed applications has renewed attention to gas bearings technology. Traditional aerostatic and aerodynamic gas lubrication has been widely used in a variety of applications, ranging from high-speed spindles to micro and meso......-scale turbomachinery. The present paper deals with experimental rotordynamic testing of a flexible rotor supported by hybrid aerostaticaerodynamic gas journal bearing equipped with an electronic radial air injection system. From a rotordynamic point of view there are two phenomena that limit the widespread...... of traditional gas lubrication: 1) Low damping makes operation across critical speed dangerous, as even low level of unbalance can generate large vibration responses. This is especially problematic for gas bearing applications, which often operate in the supercritical region. Moreover, 2) An upper bound...

  18. Influence of the Annealing Temperature on the Photovoltaic Performance and Film Morphology Applying Novel Thermocleavable Materials

    DEFF Research Database (Denmark)

    Petersen, Martin Helgesen; Bjerring, Morten; Nielsen, Niels Chr.;

    2010-01-01

    photovoltaic devices as mixtures with soluble methanofullerenes. The positioning of the ester groups proved to be very significant despite the identical conjugated backbone of 2-methyl-2-hexyl 5-(4,4-bis(2-ethylhexyl)-4H-cyclopenta[1,2-b:5,4-b′]dithiophen-2-yl)-2-(7-(3-(((2-methylhexan-2-yl...... a weight loss around 200 °C corresponding to elimination of the ester side chains followed by a second weight loss around 300 °C corresponding to loss of CO2 via decarboxylation. The temperature of thermocleavage of the active layer films was optimized to 265 °C whereby the T2:PCBM solar cells maintained...

  19. Exciton diffusion length in some thermocleavable polythiophenes by the surface photovoltage method

    DEFF Research Database (Denmark)

    Tousek, J.; Touskova, J.; Remes, Z.

    2012-01-01

    Poly-3-(2-methylhexyloxycarbonyl) dithiophene (P3MHOCT), poly-3-carboxydithiophene (P3CT) and polythiophene (PT) polymers were studied by optical and optoelectronic methods to find diffusion length as one of the important parameters characterizing them as candidates for solar cells. Their important...... be ascribed to the increase of the crystalline fraction. The highest diffusion length was found in P3CT polymer but its large resistivity represents a disadvantage in application in solar cells. Taking into account just these parameters, relatively low resistivity together with quite high diffusion length (13...... ± 2 nm) predetermine the native polythiophene among the polymers studied in the present work as the best candidate for construction of solar cells....

  20. Grizzly bear habitat selection is scale dependent.

    Science.gov (United States)

    Ciarniello, Lana M; Boyce, Mark S; Seip, Dale R; Heard, Douglas C

    2007-07-01

    The purpose of our study is to show how ecologists' interpretation of habitat selection by grizzly bears (Ursus arctos) is altered by the scale of observation and also how management questions would be best addressed using predetermined scales of analysis. Using resource selection functions (RSF) we examined how variation in the spatial extent of availability affected our interpretation of habitat selection by grizzly bears inhabiting mountain and plateau landscapes. We estimated separate models for females and males using three spatial extents: within the study area, within the home range, and within predetermined movement buffers. We employed two methods for evaluating the effects of scale on our RSF designs. First, we chose a priori six candidate models, estimated at each scale, and ranked them using Akaike Information Criteria. Using this method, results changed among scales for males but not for females. For female bears, models that included the full suite of covariates predicted habitat use best at each scale. For male bears that resided in the mountains, models based on forest successional stages ranked highest at the study-wide and home range extents, whereas models containing covariates based on terrain features ranked highest at the buffer extent. For male bears on the plateau, each scale estimated a different highest-ranked model. Second, we examined differences among model coefficients across the three scales for one candidate model. We found that both the magnitude and direction of coefficients were dependent upon the scale examined; results varied between landscapes, scales, and sexes. Greenness, reflecting lush green vegetation, was a strong predictor of the presence of female bears in both landscapes and males that resided in the mountains. Male bears on the plateau were the only animals to select areas that exposed them to a high risk of mortality by humans. Our results show that grizzly bear habitat selection is scale dependent. Further, the

  1. Wear Analysis of Wind Turbine Gearbox Bearings

    Energy Technology Data Exchange (ETDEWEB)

    Blau, Peter Julian [ORNL; Walker, Larry R [ORNL; Xu, Hanbing [ORNL; Parten, Randy J [ORNL; Qu, Jun [ORNL; Geer, Tom [ORNL

    2010-04-01

    The objective of this effort was to investigate and characterize the nature of surface damage and wear to wind turbine gearbox bearings returned from service in the field. Bearings were supplied for examination by S. Butterfield and J. Johnson of the National Wind Technology Center (NREL), Boulder, Colorado. Studies consisted of visual examination, optical and electron microscopy, dimensional measurements of wear-induced macro-scale and micro-scale features, measurements of macro- and micro-scale hardness, 3D imaging of surface damage, studies of elemental distributions on fracture surfaces, and examinations of polished cross-sections of surfaces under various etched and non-etched conditions.

  2. Coated Conductors for the Magnetic Bearing Application

    Science.gov (United States)

    Sass, Felipe; Dias, Daniel Henrique Nogueira; Sotelo, Guilherme Gonçalves; Júnior, Rubens de Andrade

    The second generation (2G) of superconductor wires have been considered for several applications lately. This work presents a preliminary study of superconducting magnetic bearings (SMB) using 2G wires as passive levitators. A superconducting block using stacked 2G wires was built to evaluate the magnetic bearing behavior, thought levitation force measurements, when a permanent magnet cylinder approaches or moves away from the block. The superconducting block was compared with an YBCO bulk with nearly the same dimensions and the results show a promising potential for this application.

  3. Cavitation wear resistance of engine bearing materials

    Science.gov (United States)

    Rac, Aleksandar

    1994-04-01

    The resistance to cavitation erosion of aluminum alloy, and cast and sinte-red lead-bronze, materials which are most frequently used for engine bearings, has been evaluated. The tests were carried out in motor oil at a temperature of 80 C, using a magnetostrictive vibratory tester (20 kHz). The results showed that the cavitation erosion resistance was the greatest in cast lead-bronze. On the contrary, sintered lead-bronze, though of the same chemical composition, had the greatest erosion rate. Additionally, the investigation of the overlay plated bearings showed the overlay was nonresistive to this type of wear.

  4. Grouted Pile and Its Bearing Capacity

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The grouting method applied in bored pile is an improvement to the conventional bored pile. Load tests have proved that grouting under the bored pile tip is an effective method to enhance the bearing capacity of the pile and to reduce the pile settlement. In this paper, the grouting technology is described and pile-load test results are discussed. In order to put the grouting method into design practice, the authors analyze the working mechanism of soil compaction. And, based on the theory of cavities expansion in soil mass, approximate formulae are proposed for estimating the bearing capacity of the grouted pile. The theoretical prediction agrees well with the load test results.

  5. Synthesis, Crystal Structure and Thermal Stability of a Saturated Dimeric Ce(Ⅲ)-chelated Complex Based on Benzoate and 1,10-Phenanthroline Ligands

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The title complex, [Ce(BA)3phen]2 (BA = benzoate, phen = 1,10-phenanthroline),was prepared by the reaction of Ce(NO3)3·6H2O, benzoic acid and 1,10-phenanthroline. The complex was characterized by single-crystal X-ray diffraction, elemental analysis, IR spectra and TG-DTG techniques. The results show that the crystal is of triclinic, space group P(1) with a =10.912(2), b = 11.962(3), c = 12.474(3)(A), a = 104.889(3), β = 93.523(3), γ = 113.332(3)°,C66H46Ce2N4O12, Mr = 1366.90, V= 1420.2(6) (A)3, Z = 1, Dc = 1.598 g/cm3,μ = 1.652 mm-1, S =1.024 and F(000) = 682. The final R = 0.0391 and wR = 0.0947 for 4878 observed reflections with I > 2σ(1). The structure of the title complex consists of two Ce(C6H5COO)3(C12H8N2) units,forming a binuclear molecule. Each Ce(Ⅲ) is coordinated by two O atoms of one bidentate chelating carboxylate group, five O atoms of two bidentate bridging and two tridentate chelating-bridging carboxylate groups, and two N atoms of one 1,10-phenanthroline molecule to complete a distorted monocapped square antiprism geometry. Its thermogravimetric analysis was determined by TG-DTG techniques.

  6. Toxic effects of sub-chronic exposure of male albino rats to emamectin benzoate and possible ameliorative role of Foeniculum vulgare essential oil.

    Science.gov (United States)

    El-Sheikh, El-Sayed A; Galal, Azza A A

    2015-05-01

    Emamectin benzoate (EB) is an avermectin insecticide used extensively in pest control on vegetable and field crops. Few studies have been done for evaluating adverse effects of EB. In the current study, we evaluated the toxic effects of EB on male rats and the possible ameliorative role of fennel essential oil (FEO). Thirty two male rats were randomly divided into 4 equal groups. All groups were treated orally with distilled water (control group), 0.5mlFEOkg(-1) BW (FEO group), 2.5mgEBkg(-1) BW (EB group), and 0.5mlFEOkg(-1) BW+2.5mgEBkg(-1) BW (FEO+EB group) for 28 days. The obtained results showed that EB treatment resulted in a significant decrease in body weight, body weight gain, RBC count, Hb concentration, % PCV, MCV and MCHC. Moreover, EB significantly decreased total leukocyte, lymphocyte, monocyte and platelet count but significantly increased granulocyte count. EB markedly decreased total protein, albumin, globulin, IgG and IgM concentrations with a significant increase in TNF-α secretion. EB had a negative impact on the liver as it significantly increased ALT, ALP, and MDA, while decreasing SOD activity. Regarding to the histopathological examination, EB treatment induced coagulative necrosis and blood vessels congestion of the liver in treated rats. Furthermore, it resulted in depletion and necrosis of the white pulp of the spleen in treated rats. The co-administration of FEO with EB, however, improved the majority of parameters studied, suggesting that FEO is an important substance in decreasing toxic effects of EB.

  7. Biological effects of the anti-parasitic chemotherapeutant emamectin benzoate on a non-target crustacean, the spot prawn (Pandalus platyceros Brandt, 1851) under laboratory conditions

    Energy Technology Data Exchange (ETDEWEB)

    Veldhoen, Nik [Department of Biochemistry and Microbiology, University of Victoria, P.O. Box 3055, Stn CSC, Victoria, BC, V8W 3P6 (Canada); Ikonomou, Michael G. [Institute of Ocean Sciences, Fisheries and Oceans Canada, 9860 West Saanich Road, P.O. Box 6000, Sidney, BC, V8L 4B2 (Canada); Buday, Craig [Pacific Environmental Science Centre, Environment Canada, 2645 Dollarton Highway, North Vancouver, BC, V7H 1V2 (Canada); Jordan, Jameson; Rehaume, Vicki; Cabecinha, Melissa [Department of Biochemistry and Microbiology, University of Victoria, P.O. Box 3055, Stn CSC, Victoria, BC, V8W 3P6 (Canada); Dubetz, Cory; Chamberlain, Jon [Institute of Ocean Sciences, Fisheries and Oceans Canada, 9860 West Saanich Road, P.O. Box 6000, Sidney, BC, V8L 4B2 (Canada); Pittroff, Sabrina; Vallee, Kurtis [Department of Biochemistry and Microbiology, University of Victoria, P.O. Box 3055, Stn CSC, Victoria, BC, V8W 3P6 (Canada); Aggelen, Graham van [Pacific Environmental Science Centre, Environment Canada, 2645 Dollarton Highway, North Vancouver, BC, V7H 1V2 (Canada); Helbing, Caren C., E-mail: chelbing@uvic.ca [Department of Biochemistry and Microbiology, University of Victoria, P.O. Box 3055, Stn CSC, Victoria, BC, V8W 3P6 (Canada)

    2012-02-15

    The potential impact of commercial salmon aquaculture along the coast of British Columbia on the health of non-target marine wildlife is of growing concern. In the current initiative, the biological effects on gene expression within spot prawn (Pandalus platyceros) exposed to the sea lice controlling agent, emamectin benzoate (EB; 0.1-4.8 mg/kg sediment), were investigated. A mean sediment/water partitioning coefficient (K{sub p}) was determined to be 21.81 and significant levels of EB were detected in the tail muscle tissue in all exposed animals. Animals selected for the experiment did not have eggs and were of similar weight. Significant mortality was observed within 8 days of EB treatment at concentrations between 0.1 and 0.8 mg/kg and there was no effect of EB on molting. Twelve spot prawn cDNA sequences were isolated from the tail muscle either by directed cloning or subtractive hybridization of control versus EB exposed tissues. Three of the transcripts most affected by EB exposure matched sequences encoding the 60S ribosomal protein L22, spliceosome RNA helicase WM6/UAP56, and the intracellular signal mediator histidine triad nucleotide binding protein 1 suggesting that translation, transcription regulation, and apoptosis pathways were impacted. The mRNA encoding the molting enzyme, {beta}-N-acetylglucosaminidase, was not affected by EB treatment. However, the expression of this transcript was extremely variable making it unsuitable for effects assessment. The results suggest that short-term exposure to EB can impact biological processes within this non-target crustacean.

  8. Structural and spectroscopic characterization of 1-(diaminomethylene) thiouron-1-ium benzoate and bis(1-(diaminomethylene)thiouron-1-ium) phthalate trihydrate

    Science.gov (United States)

    Perpétuo, Genivaldo Julio; Janczak, Jan

    2016-02-01

    Two single crystals of 1-(diaminomethylene) thiouron-1-ium benzoate (1) and bis(1-(diaminomethylene)thiouron-1-ium) phthalate trihydrate (2) were grown using a solution growth technique. The compound 1 crystallises in the centrosymmetric P21/c space group of the monoclinic system, whereas the compound 2 in the centrosymmetric Pbcn space group of orthorhombic system. The solid-state organisation of 1 and 2 has been analysed with respect to cation-anion and hydrogen bonding interactions. The oppositely charged units interact via almost linear hydrogen bonds with the graphs of R22(8) and R21(6) forming molecular complexes. In the crystal 1 the R22(8) motif is formed by donation to the carboxylate group from amine group joined to C1 and from imine group and R21(6) motif is formed by donation to the O2 from amine group joined to C2 and from imine group, whereas in crystal 2 the graphs are formed oppositely. Interactions between the hydrogen-bonded molecular complexes in 1 lead to formation of layered 2D structure, whereas in 2, due to presence of hydrated water molecules lead to formation of 3D hydrogen-bonded supramolecular network. The obtained deuterated analogues of 1 and 2 crystallise similar as H-compound in the monoclinic and orthorhombic system with quite similar lattice parameters. The compounds were also characterised by the FT-IR and Raman spectroscopies. The characteristic bands of the functional and skeletal groups are discussed.

  9. Food additives such as sodium sulphite, sodium benzoate and curcumin inhibit leptin release in lipopolysaccharide-treated murine adipocytes in vitro.

    Science.gov (United States)

    Ciardi, Christian; Jenny, Marcel; Tschoner, Alexander; Ueberall, Florian; Patsch, Josef; Pedrini, Michael; Ebenbichler, Christoph; Fuchs, Dietmar

    2012-03-01

    Obesity leads to the activation of pro-inflammatory pathways, resulting in a state of low-grade inflammation. Recently, several studies have shown that the exposure to lipopolysaccharide (LPS) could initiate and maintain a chronic state of low-grade inflammation in obese people. As the daily intake of food additives has increased substantially, the aim of the present study was to investigate a potential influence of food additives on the release of leptin, IL-6 and nitrite in the presence of LPS in murine adipocytes. Leptin, IL-6 and nitrite concentrations were analysed in the supernatants of murine 3T3-L1 adipocytes after co-incubation with LPS and the food preservatives, sodium sulphite (SS), sodium benzoate (SB) and the spice and colourant, curcumin, for 24 h. In addition, the kinetics of leptin secretion was analysed. A significant and dose-dependent decrease in leptin was observed after incubating the cells with SB and curcumin for 12 and 24 h, whereas SS decreased leptin concentrations after 24 h of treatment. Moreover, SS increased, while curcumin decreased LPS-stimulated secretion of IL-6, whereas SB had no such effect. None of the compounds that were investigated influenced nitrite production. The food additives SS, SB and curcumin affect the leptin release after co-incubation with LPS from cultured adipocytes in a dose- and time-dependent manner. Decreased leptin release during the consumption of nutrition-derived food additives could decrease the amount of circulating leptin to which the central nervous system is exposed and may therefore contribute to an obesogenic environment.

  10. Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer's Disease.

    Directory of Open Access Journals (Sweden)

    Khushbu K Modi

    Full Text Available This study underlines the importance of cinnamon, a commonly used natural spice and flavoring material, and its metabolite sodium benzoate (NaB in attenuating oxidative stress and protecting memory and learning in an animal model of Alzheimer's disease (AD. NaB, but not sodium formate, was found to inhibit LPS-induced production of reactive oxygen species (ROS in mouse microglial cells. Similarly, NaB also inhibited fibrillar amyloid beta (Aβ- and 1-methyl-4-phenylpyridinium(+-induced microglial production of ROS. Although NaB reduced the level of cholesterol in vivo in mice, reversal of the inhibitory effect of NaB on ROS production by mevalonate, and geranylgeranyl pyrophosphate, but not cholesterol, suggests that depletion of intermediates, but not end products, of the mevalonate pathway is involved in the antioxidant effect of NaB. Furthermore, we demonstrate that an inhibitor of p21rac geranylgeranyl protein transferase suppressed the production of ROS and that NaB suppressed the activation of p21rac in microglia. As expected, marked activation of p21rac was observed in the hippocampus of subjects with AD and 5XFAD transgenic (Tg mouse model of AD. However, oral feeding of cinnamon (Cinnamonum verum powder and NaB suppressed the activation of p21rac and attenuated oxidative stress in the hippocampus of Tg mice as evident by decreased dihydroethidium (DHE and nitrotyrosine staining, reduced homocysteine level and increased level of reduced glutathione. This was accompanied by suppression of neuronal apoptosis, inhibition of glial activation, and reduction of Aβ burden in the hippocampus and protection of memory and learning in transgenic mice. Therefore, cinnamon powder may be a promising natural supplement in halting or delaying the progression of AD.

  11. Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamino) Benzoate.

    Science.gov (United States)

    Lin, Wen-Ying; Sohma, Yoshiro; Hwang, Tzyh-Chang

    2016-09-01

    Cystic fibrosis (CF) is caused by loss-of-function mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene encoding a phosphorylation-activated but ATP-gated chloride channel. Previous studies suggested that VX-770 [ivacaftor, N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide], a CFTR potentiator now used in clinics, increases the open probability of CFTR by shifting the gating conformational changes to favor the open channel configuration. Recently the chloride channel blocker and CFTR potentiator 5-nitro-2-(3-phenylpropylamino) benzoate (NPPB) has been reported to enhance CFTR activity by a mechanism that exploits the ATP hydrolysis-driven, nonequilibrium gating mechanism unique to CFTR. Surprisingly however, NPPB increased the activity of nonhydrolytic G551D-CFTR, the third most common disease-associated mutation. Here, we further investigated the mechanism of NPPB's effects on CFTR gating by assessing its interaction with well-studied VX-770. Interestingly, once G551D-CFTR was maximally potentiated by VX-770, NPPB further increased its activity. However, quantitative analysis of this drug-drug interaction suggests that this pharmacologic synergism is not due to independent actions of NPPB and VX-770 on CFTR gating; instead, our data support a dependent mechanism involving two distinct binding sites. This latter idea is further supported by the observation that the locked-open time of a hydrolysis-deficient mutant K1250A was shortened by NPPB but prolonged by VX-770. In addition, the effectiveness of NPPB, but not of VX-770, was greatly diminished in a mutant whose second nucleotide-binding domain was completely removed. Interpreting these results under the framework of current understanding of CFTR gating not only reveals insights into the mechanism of action for different CFTR potentiators but also brings us one step forward to a more complete schematic for CFTR gating.

  12. Impact of Fixed-Bearing and Mobile-Bearing Tibial Insert in Unicondylar Knee Arthroplasty

    Directory of Open Access Journals (Sweden)

    Mehmet Faruk Çatma

    2016-06-01

    Full Text Available INTRODUCTION: The aim of the study is to investigate the impact of fixed or mobile-bearing tibial inserts on patellofemoral arthrosis and evaluate which one to be preferred for patients with patellofemoral arthrosis. METHODS: Operated in our clinic between January 2009 and February 2013, 33 with patellofemoral arthritis together with anteromedial compartment arthritis were included in the study. Patellofemoral joints of patients were evaluated according to the scoring system defined by Fulkerson-Shea. RESULTS: Unicondylar knee arthroplasty with fixed-bearing tibial insertsand 22 (66,6% (male: 3, female: 19 and unicondylar knee arthroplasty with mobile-bearing tibial inserts 11 (33,9 % (male: 2, female: 9 were implanted.Average knee flexion was found to be 116,5 (100-135 degrees in 22 patients with mobile-bearing tibial inserts, and 114,5 (95-135 in 11 patients with fixed-bearing tibial inserts. DISCUSSION AND CONCLUSION: Patellofemoral arthrosis is an important factor for unicondylar knee arthroplasty prognosis and one of the determinants of patient satisfaction. Significantly less patellofemoral complaints were seen with UKA with fixed-bearing tibial insert compared to mobile-bearing tibial insert.

  13. Dynamic Analysis of a Rotor-Bearing-SFD System with the Bearing Inner Race Defect

    Directory of Open Access Journals (Sweden)

    Junhong Zhang

    2017-01-01

    Full Text Available In this paper, the dynamic behavior of a rotor-bearing-SFD system with the inner race defect of bearing is investigated. The contact force between the rolling element and the race is calculated in Hertzian contact and elastohydrodynamic lubrication condition. The supporting force of the SFD is simulated by integrating the pressure distribution derived from Reynolds’s equation. The equations of motion of the rotor-bearing-SFD system are derived and solved using the fourth-order Runge-Kutta method. The dynamic behavior and the fault characteristics are analyzed with two configurations of the SFD: (1 mounted on the unfaulted bearing and (2 mounted on the faulty bearing. According to the analysis of time-frequency diagram, waterfall plot, and spectral diagram, the results show that the characteristics of inner race defects on bearing frequencies are related to the characteristic multiple frequency of the inner race defect and the fundamental frequency. The speed and defect width have different influence on the distribution and amplitude of frequency. The SFD can enhance the system stability under the bearing fault but the enhancement decreases with the increasing speed. Meanwhile, the beneficial effect of the SFD varies according to the mounted position in the rotor system.

  14. Local Attitudes towards Bear Management after Illegal Feeding and Problem Bear Activity

    Directory of Open Access Journals (Sweden)

    David Fraser

    2013-09-01

    Full Text Available The “pot bears” received international media attention in 2010 after police discovered the intentional feeding of over 20 black bears during the investigation of an alleged marijuana-growing operation in Christina Lake, British Columbia, Canada. A two-phase random digit dialing survey of the community was conducted in 2011 to understand local perspectives on bear policy and management, before and after a summer of problem bear activity and government interventions. Of the 159 households surveyed in February 2011, most had neutral or positive attitudes towards bears in general, and supported the initial decision to feed the food-conditioned bears until the autumn hibernation. In contrast to wildlife experts however, most participants supported relocating the problem bears, or allowing them to remain in the area, ahead of killing; in part this arose from notions of fairness despite the acknowledged problems of relocation. Most locals were aware of the years of feeding but did not report it, evidently failing to see it as a serious form of harm, even after many bears had been killed. This underscores the importance of preventive action on wildlife feeding and the need to narrow the gap between public and expert opinion on the likely effects of relocation versus killing.

  15. Lubricant replacement in rolling element bearings for weapon surety devices

    Energy Technology Data Exchange (ETDEWEB)

    Steinhoff, R.; Dugger, M.T.; Varga, K.S. [Sandia National Laboratories, Albuquerque, NM (United States)

    1996-05-01

    Stronglink switches are a weapon surety device that is critical to the nuclear safety theme in modem nuclear weapons. These stronglink switches use rolling element bearings which contain a lubricant consisting of low molecular weight polytetrafluoroethylene (PTFE) fragments. Ozone-depleting solvents are used in both the manufacture and application of this lubricant. An alternate bearing lubrication for stronglink switches is needed that will provide long-term chemical stability, low migration and consistent performance. Candidates that were evaluated include bearings with sputtered MoS{sub 2} on the races and retainers, bearings with TiC-coated balls, and bearings with Si{sub 3}N{sub 4} balls and steel races. These candidates were compared to the lubricants currently used which are bearings lubricated with PTFE fragments of low molecular weight in a fluorocarbon solvent. The candidates were also compared to bearings lubricated with a diester oil which is representative of bearing lubricants used in industrial applications. Evaluation consisted of cycling preloaded bearings and subjecting them to 23 gRMS random vibration. All of the candidates are viable substitutes for low load application where bearing preload is approximately 1 pound. For high load applications where the bearing preload is approximately 10 pounds, bearings with sputtered MoS{sub 2} on the races and retainers appear to be the best substitutes. Bearings with TiC-coated balls also appear to be a viable candidate but these bearings did not perform as well as the sputtered MoS{sub 2}.

  16. An electrochemical sensor for rizatriptan benzoate determination using Fe{sub 3}O{sub 4} nanoparticle/multiwall carbon nanotube-modified glassy carbon electrode in real samples

    Energy Technology Data Exchange (ETDEWEB)

    Madrakian, Tayyebeh, E-mail: madrakian@basu.ac.ir; Maleki, Somayeh; Heidari, Mozhgan; Afkhami, Abbas

    2016-06-01

    In this paper a sensitive and selective electrochemical sensor for determination of rizatriptan benzoate (RZB) was proposed. A glassy carbon electrode was modified with nanocomposite of multiwalled carbon nanotubes (MWCNTs) and Fe{sub 3}O{sub 4} nanoparticles (Fe{sub 3}O{sub 4}/MWCNTs/GCE). The results obtained clearly show that the combination of MWCNTs and Fe{sub 3}O{sub 4} nanoparticles definitely improves the sensitivity of modified electrode to RZB determination. The morphology and electroanalytical performance of the fabricated sensor were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDS), square wave voltammetry (SWV) and cyclic voltammetry (CV). Also, the effect of experimental and instrumental parameters on the sensor response was evaluated. The square wave voltammetric response of the electrode to RZB was linear in the range 0.5–100.0 μmol L{sup −1} with a detection limit of 0.09 μmol L{sup −1} under the optimum conditions. The investigated method showed good stability, reproducibility and repeatability. The proposed sensor was successfully applied for real life samples of blood serum and RZB determination in pharmaceutical. - Highlights: • Simple and sensitive Fe{sub 3}O{sub 4}/MWCNTs/GCE for rizatriptan benzoate determination • The surface morphology of nanocomposite was characterized by SEM and EDS. • Rizatriptan benzoate was measured at 0.09 μmol L{sup −1} with good sensitivity and selectivity. • The electrode has been successfully applied in serum and pharmaceutical samples. • The nanocomposite had excellent electrocatalytic activity and biocompatibility.

  17. Tests of Lead-bronze Bearings in the DVL Bearing-testing Machine

    Science.gov (United States)

    Fischer, G

    1940-01-01

    The lead-bronze bearings tested in the DVL machine have proven themselves very sensitive to load changes as in comparison with bearings of light metal. In order to prevent surface injuries and consequently running interruptions, the increase of the load has to be made in small steps with sufficient run-in time between steps. The absence of lead in the running surface, impurities in the alloy (especially iron) and surface irregularities (pores) decreases the load-carrying capacity of the bearing to two or three times that of the static load.

  18. NANO-BEARING: THE DESIGN OF A NEW TYPE OF AIR BEARING WITH FLEXURE STRUCTURE

    Institute of Scientific and Technical Information of China (English)

    KO Pui Hang; DU Ruxu

    2007-01-01

    A new type of air bearing with flexure structure is introduced. The new bearing is designed for precision mechanical engineering devices such as mechanical watch movement. The new design uses the flexure structure to provide 3D damping to absorb shocks from all directions. Two designs are presented: one has 12 T-shape slots in the radian direction while the other has 8 spiral slots in the radian direction. Both designs have flexure mountings on the axial directions. Based on the finite element analysis (FEA), the new bearing can reduce the vibration (displacement) by as much as 8.37% and hence, can better protect the shafts.

  19. MAGNETIC FLUID BEARINGS OF MINING EQUIPMENT

    Directory of Open Access Journals (Sweden)

    I. Gorlov

    2012-01-01

    Full Text Available The paper considers a problem pertaining to selection friction pair materials for plain bearings of mining equipment which are lubricated with  nano-dispersed magnetic oil. Methodology for equipment tests, technology for obtaining new anti-friction materials (polymer, ceramic, amorphous and investigation results are presented in the paper.

  20. Heavy Bearings Exploitation Energy and Reduction Methods

    Science.gov (United States)

    Szekely, V. G.; Cioară, R.

    2016-11-01

    The global trend of resource conservation so as “not to compromise the ability of future generation's development” is the fundamental basis of the concept of sustainable development. Concordant with this, the energy efficiency of products is increasingly discussed and frequently taken into account in the design stage. In more cases a product is more appreciated and more attractive as the energy consumption and its associated materials are lower. In the production stage, said consumption advantages primarily the manufacturer, particularly through low consumption thereof. In the operational phase, low energy and materials consumption represents an user advantage and it's a major argument in the decision to purchase and use a particular product. Heavy bearings are frequent products used in wind turbines that are producing non-conventional “clean” energy, as windmills. An enhanced energy efficiency bearing contributes to the enhancement of the overall efficiency of the wind turbines. Based on a suitable mathematical model, this paper identifies and recommends courses of action to reduce the operating energy of heavy bearing through the “cage” - which is the subject of a much larger research - with the highest priority. The identified actions may constitute from a set of requirements for the design stage of the heavy bearing predominantly oriented towards innovation-invention.

  1. Load Bearing Equipment for Bone and Muscle

    Science.gov (United States)

    Shackelford, Linda; Griffith, Bryan

    2015-01-01

    Resistance exercise on ISS has proven effective in maintaining bone mineral density and muscle mass. Exploration missions require exercise with similar high loads using equipment with less mass and volume and greater safety and reliability than resistance exercise equipment used on ISS (iRED, ARED, FWED). Load Bearing Equipment (LBE) uses each exercising person to create and control the load to the partner.

  2. Ball bearing measurement with white light interferometry

    Science.gov (United States)

    Schmit, Joanna; Han, Sen; Novak, Erik

    2009-06-01

    Requirements on high-performance of ball bearings in terms of the loads they experience and their reliability are increasing as the automotive, aerospace, and power generation industries look to cut costs, reduce emissions, and improve efficiency. Most bearings are evaluated with a stylus profiler or with a bright field scopes or microscopes for form, roughness, and defect classification. Two-dimensional stylus measurements captures only very localized surface profiles unless multiple scans are performed which slow the measurement time unacceptably; this leads to inadequate sampling and sometimes greatly varying results based on location and directionality of the line scan. Bright field microscopes deliver only the lateral information about defects but not their depth, volume or surface roughness. White light interferometry can be very successfully utilized in the measurement of full field form, roughness and defect detection and is gaining adoption. They provide rapid, accurate, three-dimensional imaging compatible with the newly developed ISO 3D surface parameters which are expected to rapidly displace traditional 2D metrics. These surface parameters allow for better characterization of surface structure and better understanding of the production process and bearing and race wear. New 3D filtering techniques allow effective separation of form, waviness, and roughness for highly accurate and repeatable bearing qualification.

  3. The economics of roadside bear viewing

    Science.gov (United States)

    Richardson, Leslie; Rosen, Tatjana; Gunther, Kerry; Schwartz, Chuck

    2014-01-01

    Viewing bears along roadside habitats is a popular recreational activity in certain national parks throughout the United States. However, safely managing visitors during traffic jams that result from this activity often requires the use of limited park resources. Using unique visitor survey data, this study quantifies economic values associated with roadside bear viewing in Yellowstone National Park, monetary values that could be used to determine whether this continued use of park resources is warranted on economic grounds. Based on visitor expenditure data and results of a contingent visitation question, it is estimated that summer Park visitation would decrease if bears were no longer allowed to stay along roadside habitats, resulting in a loss of 155 jobs in the local economy. Results from a nonmarket valuation survey question indicate that on average, visitors to Yellowstone National Park are willing to pay around $41 more in Park entrance fees to ensure that bears are allowed to remain along roads within the Park. Generalizing this value to the relevant population of visitors indicates that the economic benefits of allowing this wildlife viewing opportunity to continue could outweigh the costs of using additional resources to effectively manage these traffic jams.

  4. Horizontal Air Bearing Experiment Number 1

    Energy Technology Data Exchange (ETDEWEB)

    Clauson, T.L.

    1999-08-31

    The Horizontal Air Bearing Experiment No.1 is a series of tests intended to further the understanding of rotational dynamics. A simple experimental assembly is rotated using the Horizontal Air Bearing and allowed to spin freely as the internal rotational damping is measured. The low friction of the bearing effectively isolates the test assembly, allowing the internal damping of the test object to be evaluated. The experimental assembly is composed of an aluminum ball within a spherical cavity. A flanged pipe section and an auxiliary adapter plate secure the assembly to the Air Bearing interface plate. Three aluminum balls are interchanged to vary test parameters. The aluminum balls are free to move independently as the entire assembly rotates. The aluminum balls vary in diameter and/or surface finish. While the diameter and surface finish is varied, the space between the ball and socket is dry. To examine the effect of viscosity, the space is filled with a lubricant while the ball diameter and surface finish is held constant.

  5. Load-Bearing Capacity of Roof Trusses

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Damkilde, Lars; Munch-Andersen, J.

    2004-01-01

    systems such as roof trusses are established and statistical characteristics of the load bearing capacity are determined. The results show that there is a significant increase in the characteristic (nominal) value and a reduction in the coefficient of variation (COV) for typical loads such as permanent...

  6. Extended Life Testing of Duplex Ball Bearings

    Science.gov (United States)

    Mobley, Jeffrey; Robertson, Michael; Hodges, Charles

    2016-01-01

    Sierra Nevada Corporation’s Space Systems performed bearing life testing for the Scan Mirror Motor/Encoder Assembly (SMMA), part of the Scan Mirror Assembly on-board the Aerosol Polarimetry Sensor (APS) on the NASA Glory Spacecraft. The baseline bearing life test duration extended beyond the launch date for the Glory Spacecraft; a risk that the program was willing to undertake with the understanding that if any anomalies or failures occurred before the required life was achieved, then the mission objectives or operating profile could be modified on orbit to take those results into account. Even though the Glory Spacecraft failed to reach orbit during its launch in March of 2011, the bearing life testing was continued through a mutual understanding of value between Sierra Nevada Corporation and our customer; with a revised goal of testing to failure rather than completing a required number of life cycles. Life testing thus far has not only exceeded the original mission required life, but has also exceeded the published test data for Cumulative Degradation Factor (CDF) from NASA/CR-2009-215681. Many lessons were learned along the way regarding long life testing. The bearing life test has been temporarily suspended due to test support equipment issues.

  7. Bearings and Seals. FOS: Fundamentals of Service.

    Science.gov (United States)

    John Deere Co., Moline, IL.

    This manual on bearings and seals is one of a series of power mechanics texts and visual aids for use in training for the servicing of automotive and off-the-road farm and industrial machines. Materials provide basic information and illustrations for use by vocational students and teachers as well as shop servicemen and laymen. Focusing on…

  8. Active Magnetic Bearings. Postgraduate Seminar on Electromechanics

    Energy Technology Data Exchange (ETDEWEB)

    Lantto, E.; Tommila, V.; Arkkio, A.

    2007-07-01

    The papers in the seminar on electromagnetics are published only as power point slides. The titles of the different papers are: Introduction to magnetic bearings, Magnetic field and forces, Actuators, amplifiers and sensors, System theory, rotordynamics and control, Diagnostics, applications and standardisation.

  9. Annular Pressure Seals and Hydrostatic Bearings

    Science.gov (United States)

    2006-11-01

    affecting the rotordynamics of liquid turbopumps, in particular those handling large density fluids. Highlights on the bulk-flow analysis of annular seals... rotordynamic stability. Hydrostatic bearings rely on external fluid pressurization to generate load support and large centering stiffnesses, even in...SEALS IN PUMP APPLICATIONS Seal rotordynamic characteristic have a primary influence on the stability response of high-performance turbomachinery [1

  10. HPLC测定布洛芬口服溶液中苯甲酸钠、安赛蜜含量%Content Determination of Sodium Benzoate and Acesulfame in Ibuprofen Oral Solution by HPLC

    Institute of Scientific and Technical Information of China (English)

    黎艳刚; 段峰; 郭丽蓉; 程飞; 王真; 杨武亮

    2013-01-01

    目的:建立HPLC测定布洛芬口服溶液中苯甲酸钠和安赛蜜含量的方法.方法:采用HPLC测定,色谱条件为J'sphere ODS-H80色谱柱(4.6 mm×250 mm,4.0 μm),流动相0.02 mol·L-1乙酸铵-甲醇(85∶ 15),流速1 mL· min-1,柱温30℃,检测波长230 nm,进样量10 μL.结果:苯甲酸钠和安赛蜜可有效分离,安赛蜜、苯甲酸钠线性范围依次为15.75 ~110.25,7.8~47.8 μg;平均回收率依次为100.51%(RSD 0.79%),100.42%(RSD 1.56%).结论:该方法灵敏、简便、重复性好,可为布洛芬口服溶液中苯甲酸钠和安赛蜜的含量测定提供参考.%Objective: To establish a HPLC method for simultaneously determining the content of sodium benzoate and acesulfame in ibuprofen oral solution. Method: The content of sodium benzoate and acesulfame was determined by HPLC, chromatographic conditions were as follows; J'sphere ODS-H80 column ( 4. 6 mm × 250 mm, 4.0 μm) , the mobile phase of methanol-0. 02 mol·L-1ammonium acetate (15:85) , column temperature 30 ℃ , the flow rate of 1. 0 mL · min-1 , detection wavelength 230 nm, the injection volume 10 μL. Result: Acesulfame showed a good linear relationship at the range of 15.75-110.25 μg, the average recovery of it was 100. 51% with RSD 0. 79% . Sodium benzoate showed a good linear relationship at the range of 7. 847. 8 μg, the average recovery was 100.42% with RSD 1.56%. Conclusion: This method was sensitive, simple and reproducible, it could provide a reference for determining the content of sodium benzoate and acesulfame in ibuprofen oral solution.

  11. Grievous Temporal and Occipital Injury Caused by a Bear Attack

    Directory of Open Access Journals (Sweden)

    Sampath Chandra Prasad

    2013-01-01

    Full Text Available Bear attacks are reported from nearly every part of the world. The chance of a human encountering a bear increases as the remote bear territory diminishes. The sloth bear is one of the three species of bears found in India, which inhabits the forests of India and its neighboring countries. Here we describe a teenager who came to us with a critical injury involving the face, temporal and occipital bones inflicted by a sloth bear attack. He underwent a temporal exploration, facial nerve decompression, pinna reconstruction, and occipital bone repair to save him from fatality.

  12. Yellowstone grizzly bear investigations: Annual report of the Interagency Grizzly Bear Study Team, 2001

    Science.gov (United States)

    Schwartz, Charles C.; Haroldson, Mark A.

    2001-01-01

    The contents of this Annual Report summarize results of monitoring and research from the 2001 field season. The report also contains a summary of nuisance grizzly bear (Ursus arctos horribilis) management actions.

  13. Yellowstone grizzly bear investigations: Annual report of the Interagency Grizzly Bear Study Team, 2004

    Science.gov (United States)

    Schwartz, Charles C.; Haroldson, Mark A.; West, Karrie K.

    2005-01-01

    The contents of this Annual Report summarize results of monitoring and research from the 2004 field season. The report also contains a summary of nuisance grizzly bear (Ursus arctos horribilis) management actions.

  14. Rotor Bearing System Analysis Using the Transfer Matrix Method with Thickness Assumption of Disk and Bearing

    CERN Document Server

    Ghasemalizadeh, Omid; Sadeghi, Hossein; Ahmadian, Mohammad Taghi

    2013-01-01

    One of the methods to find the natural frequencies of rotating systems is the application of the transfer matrix method. In this method the rotor is modeled as several elements along the shaft which have their own mass and moment of inertia. Using these elements, the entire continuous system is discretized and the corresponding differential equation can be stated in matrix form. The bearings at the end of the shaft are modeled as equivalent spring and dampers which are applied as boundary conditions to the discretized system. In this paper the dynamics of a rotor-bearing system is analyzed, considering the gyroscopic effect. The thickness of the disk and bearings is also taken into account. Continuous model is used for shaft. Results Show that, the stiffness of the shaft and the natural frequencies of the system increase, while the amplitude of vibration decreases as a consequence of increasing the thickness of the bearing.

  15. Kenai Peninsula Brown Bear Studies : Report of the Interagency Brown Bear Study Team, 1986

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes work conducted during the 1986 field season on brown bear (Ursus arctos) from the Kenai Peninsula, Alaska. Ground surveys were conducted to...

  16. Adaptation of the hindlimbs for climbing in bears.

    Science.gov (United States)

    Sasaki, Motoki; Endo, Hideki; Wiig, Oystein; Derocher, Andrew E; Tsubota, Toshio; Taru, Hajime; Yamamoto, Masako; Arishima, Kazuyoshi; Hayashi, Yoshihiro; Kitamura, Nobuo; Yamada, Junzo

    2005-04-01

    The hindlimbs of the Malayan sun bear (Helarctos malayanus), the polar bear (Ursus maritimus), the brown bear (Ursus arctos) and the giant panda (Ailuropoda melanoleuca) have been anatomically and osteometrically studied. The Musculus tibialis cranialis of the Malayan sun bear and the giant panda possessed a well-developed rich fleshy portion until the distal end of the tibia. In the polar bear and the brown bear, however, the fleshy portion of the M. tibialis cranialis was not developed until the distal end of the tibia. The tendon of the M. tibialis cranialis inserting on the proximal end of the Ossa metatarsalia was shorter in the Malayan sun bear and the giant panda than in the polar bear and the brown bear. In the Malayan sun bear and the giant panda, moreover, the M. popliteus was attached more distally to the tibia than in the polar bear and the brown bear. The stable dorsiflexion and supination of the foot and the efficient pronation of the crus are important for skillful tree climbing. The present study suggests that the Malayan sun bear and the giant panda have hindlimbs especially adapted to tree climbing by the well-developed fleshy portion of the M. tibialis cranialis reaching the distal end of the tibia, its short tendon, and the M. popliteus inserting near the distal end of the tibia.

  17. THE STRUCTURAL ANALYSIS OF STEEL SILOS WITH CYLINDRICAL-WALL BEARING AND PROFILE-STEEL BEARING

    OpenAIRE

    Zhengjun Tang; Daibiao Zhou; Chenwei Peng; Wenping Wu

    2015-01-01

    The silos are widely used in bulk material in many fields such as agriculture, mining, chemical, electric power storage, etc. Thin metal cylindrical silo shells are vulnerable to buckling failure caused by the compressive wall friction force. In this paper, the structural analysis of two types of steel silo with cylindrical-wall bearing and profile-steel bearing is implemented by Abaqus finite element analysis. The results indicate that under the same loading conditions, steel silos with prof...

  18. Investigation of tribological and mechanical properties of metal bearings

    Indian Academy of Sciences (India)

    Bekir Sadik Ünlü

    2009-08-01

    Copper, aluminum and tin–lead based alloys are widely used as journal bearing materials in tribological applications. Bronze and brass are widely used as journal bearing materials for copper based alloys. Zamacs find applications as journal bearing materials for zinc based alloys, while duralumines are chosen as journal bearing materials for aluminum based alloys. In addition, white metals are widely used as journal bearing materials for tin–lead based alloys. These alloys ensure properties expected from journal bearings. In this study, tribological and mechanical properties of these journal bearings manufactured by metals were investigated. SAE 1050 steel shaft was used as counter abrader. Experiments were carried out in every 30 min for a total of 150 min by using radial journal bearing wear test rig.

  19. Land protection plan : Bear River Watershed Conservation Area

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The U.S. Fish and Wildlife Service is establishing a conservation area for the Bear River watershed in Idaho, Utah, and Wyoming. The Bear River Watershed...

  20. Interchangeable Bearings for Profile and Weight Trade Studies Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Air-Lock, Incorporated is proposing to design fully sealed shoulder and arm bearings with interchangeable bearing housings. The interchangeable housings shall be...

  1. Kodiak brown bear population on Kodiak Island, Alaska

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Methods and estimates of the Brown bear population on Kodiak Island. The total number of Kodiak Brown Bears on Kodiak Island has been estimated to be 1669. Three...

  2. Polar bear den survey, Arctic National Wildlife Range

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — In conjunction with the Polar Bear Research Project being supervised by Mr. Jack Lentfer of the Bureau of Sport Fisheries and Wildlife two Polar Bear den surveys...

  3. Self-Bearing Motor-Generator for Flywheels Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Self-bearing or ?bearingless? motors perform both motor and bearing support functions but such devices have not yet achieved speeds above 15,000 rpm. The innovation...

  4. A plan for the management of the Kodiak brown bear

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Management districts will be used as a tool to manage the population of bear on Kodiak Island. Theoretically, 204 bear may be taken off the refuge annually without...

  5. Modeling of Hybrid Permanent Magnetic-Gas Bearings

    DEFF Research Database (Denmark)

    Morosi, Stefano; Santos, Ilmar

    2009-01-01

    Modern turbomachinery applications require nowadays ever-growing rotational speeds and high degree of reliability. It then becomes natural to focus the attention of the research to contact-free bearings elements. The present alternatives focus on gas lubricated journal bearings or magnetic bearings....... In the present paper, a detailed mathematical modeling of the gas bearing based on the compressible form of the Reynolds equation is presented. Perturbation theory is applied in order to identify the dynamic characteristic of the bearing. Due to the simple design of the magnetic bearings elements - being...... the rotor equilibrium position can be made independent on the rotational speed and applied load; it becomes function of the passive magnetic bearing offset. By adjusting the offset it is possible to significantly influence the dynamic coefficients of the hybrid bearing....

  6. Population Parameters and Harvest Characteristics of Black Bears in Georgia

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes findings of black bear distribution and population trends throughout Georgia and evaluates black bear harvest trends from 1992 to 2002....

  7. Bear range-grazing area survey: Joint report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Recommendations for establishing livestock grazing area, consistent with refuge purposes and minimization of bear attacks. Includes statistics on bear kills,...

  8. Blade Bearing Friction Estimation of Operating Wind Turbines

    DEFF Research Database (Denmark)

    Perisic, Nevena; Pedersen, Bo Juul; Kirkegaard, Poul Henning

    2012-01-01

    Blade root bearing on a wind turbine (WTG) enables pitching of blades for power control and rotor braking and is a WTG critical component. As the size of modern WTGs is constantly increasing, this leads to relatively less rigid bearings, more sensitive to deformations, thus WTG operational...... reliability can be increased by continuous monitoring of blade bearing. High blade bearing friction is undesirable, as it may be associated with excessive heating of the surfaces, damage and/or inefficient operation. Thus, continuous observation of bearing friction level is crucial for blade bearing health...... monitoring systems. A novel algorithm for online monitoring of bearing friction level is developed combining physical knowledge about pitch system dynamics with state estimator, i.e. observer theory and signal processing assuming realistic sensor availability. Results show estimation of bearing friction...

  9. EXPERIMENTAL APPARATUS FOR EXAMINATION OF MAGNETIC FLUID LUBRICATED THURST BEARING

    Directory of Open Access Journals (Sweden)

    Józef SALWIŃSKI

    2014-06-01

    Full Text Available In recent years, there has been development of the structure of thrust bearing with magnetic fluids . The essence of this type of bearing is to maintain a liquid lubricant in a very narrow gap with magnetic fluid by a magnetic field. Such systems can act as the bearing lubrication and sealing. This paper presents description of the experimental apparatus for examination magnetic fluid lubricated thrust bearing. Description of the construction and characteristics of the measuring possibilities ware presented.

  10. Optimized Coolant-Flow Diverter For Increased Bearing Life

    Science.gov (United States)

    Subbaraman, Maria R.; Butner, Myles F.

    1995-01-01

    Coolant-flow diverter for rolling-element bearings in cryogenic turbopump designed to enhance cooling power of flow in contact with bearings and thereby reduce bearing wear. Delivers jets of coolant as close as possible to hot spots at points of contact between balls and race. Also imparts swirl that enhances beneficial pumping effect. Used with success in end ball bearing of high-pressure-oxidizer turbopump.

  11. Preclinical pharmacokinetics, tissue distribution and plasma protein binding of sodium (±-5-bromo-2-(α-hydroxypentyl benzoate (BZP, an innovative potent anti-ischemic stroke agent

    Directory of Open Access Journals (Sweden)

    Xin Tian

    2016-08-01

    Full Text Available Sodium (±-5-bromo-2-(α-hydroxypentyl benzoate (BZP is a potential cardiovascular drug and exerts potent neuroprotective effect against transient and long-term ischemic stroke in rats. BZP could convert into 3-butyl-6-bromo-1(3H-isobenzofuranone (Br-NBP in vitro and in vivo. However, the pharmacokinetic profiles of BZP and Br-NBP still have not been evaluated. For the purpose of investigating the pharmacokinetic profiles, tissue distribution and plasma protein binding of BZP and Br-NBP, a rapid, sensitive and specific method based on liquid chromatography coupled to mass spectrometry (LC-MS/MS has been developed for determination of BZP and Br-NBP in biological samples. The results indicated that BZP and Br-NBP showed a short elimination half-life, and pharmacokinetic profile in rats (3, 6 and 12 mg/kg; i.v. and beagle dogs (1, 2 and 4 mg/kg; i.v.gtt were obtained after single dosing of BZP. After multiple dosing of BZP, there was no significant accumulation of BZP and Br-NBP in the plasma of rats and beagle dogs. Following i.v. single dose (6 mg/kg to rats, BZP and Br-NBP were distributed rapidly into all tissues examined, with the highest concentrations of BZP and Br-NBP in lung and kidney, respectively. The brain distribution of Br-NBP in middle cerebral artery occlusion (MCAO rats was more than in normal rats (P<0.05. The plasma protein binding degree of BZP at three concentrations (8000, 20000 and 80000 ng/mL from rat, beagle dog and human plasma were 98.1~98.7%, 88.9~92.7% and 74.8%~83.7% respectively. In conclusion, both BZP and Br-NBP showed short half-life, good dose-linear pharmacokinetic profile, wide tissue distribution and different degree protein binding to various species plasma. This was the first preclinical pharmacokinetic investigation of BZP and Br-NBP in both rats and beagle dogs, which provided vital guidance for further preclinical research and the subsequent clinical trials.

  12. Efficiency of fixed-time artificial insemination using a progesterone device combined with GnRH or estradiol benzoate in Nellore heifers

    Directory of Open Access Journals (Sweden)

    Vinícius Antônio Pelissari Poncio

    2015-10-01

    Full Text Available he use of estrogens in artificial insemination protocols for cattle is the least expensive and most efficient method currently available. However, the trend to prohibit the use of estrogens for this purpose has made it necessary to find alternatives that replace estrogens without compromising the reproductive performance of the animals. The objective of this study was to evaluate conception rates in Bos indicus beef heifers treated with a progesterone device (P4 combined with GnRH or an estradiol ester. On day 0, pubertal Nellore heifers (n = 100 received an intravaginal device containing 1 g P4 and were randomly divided into two groups. The GnRH group (n = 49 received an intramuscular injection of 100 µg GnRH, while the E2 group (n = 51 received 2 mg estradiol benzoate (EB. The P4 device was removed after 5 (GnRH group or 8 days (E2 group, followed by an injection of 125 µg of the PGF2α, analog cloprostenol. On that occasion, the E2 group received an additional injection of 300 IU eCG. Twenty-four hours later, the GnRH group received a second injection of 125 µg cloprostenol, while the E2 group received 1 mg EB. The heifers were inseminated 72 (GnRH group or 54 hours (E2 group after removal of the P4 device. At the time of insemination, the GnRH group received additionally an injection of 100 µg GnRH. Estrus was monitored during the period of cloprostenol injection until the time of artificial insemination and pregnancy was diagnosed 40 days after insemination by transrectal ultrasonography. The data were analyzed by Fisher’s exact test. The pregnancy rate was 38.8% and 31.4% in the GnRH and E2 groups, respectively (P>0.05. The ovarian condition of the heifers (estrus or anestrus tended to influence (P=0.07 pregnancy rates in the GnRH group, but not in the E2 group. At the time of artificial insemination, 33.3% of heifers in the GnRH group showed signs of estrus versus 88.2% in the E2 group (P<0.05. However, the time of estrus

  13. Whitebark pine, grizzly bears, and red squirrels

    Science.gov (United States)

    Mattson, D.J.; Kendall, K.C.; Reinhart, D.P.; Tomback, D.F.; Arno, S.F.; Keane, R.E.

    2001-01-01

    Appropriately enough, much of this book is devoted to discussing management challenges and techniques. However, the impetus for action—the desire to save whitebark pine (Pinus albicaulis)—necessarily arises from the extent to which we cherish it for its beauty and its connections with other things that we value. Whitebark pine is at the hub of a fascinating web of relationships. It is the stuff of great stories (cf. Quammen 1994). One of the more interesting of these stories pertains to the dependence of certain grizzly bear (Ursus arctos horribilis) populations on its seeds, and the role that red squirrels (Tamiasciurus hudsonicus) play as an agent of transfer between tree and bear.

  14. Gravimeter using high-temperature superconductor bearing.

    Energy Technology Data Exchange (ETDEWEB)

    Hull, J. R.

    1998-09-11

    We have developed a sensitive gravimeter concept that uses an extremely low-friction bearing based on a permanent magnet (PM) levitated over a high-temperature superconductor (HTS). A mass is attached to the PM by means of a cantilevered beam, and the combination of PM and HTS forms a bearing platform that has low resistance to rotational motion but high resistance to horizontal, vertical, or tilting motion. The combination acts as a low-loss torsional pendulum that can be operated in any orientation. Gravity acts on the cantilevered beam and attached mass, accelerating them. Variations in gravity can be detected by time-of-flight acceleration, or by a control coil or electrode that would keep the mass stationary. Calculations suggest that the HTS gravimeter would be as sensitive as present-day superconducting gravimeters that need cooling to liquid helium temperatures, but the HTS gravimeter needs cooling only to liquid nitrogen temperatures.

  15. Static Load Distribution in Ball Bearings

    Science.gov (United States)

    Ricci, Mario

    2010-01-01

    A numerical procedure for computing the internal loading distribution in statically loaded, single-row, angular-contact ball bearings when subjected to a known combined radial and thrust load is presented. The combined radial and thrust load must be applied in order to avoid tilting between inner and outer rings. The numerical procedure requires the iterative solution of Z + 2 simultaneous nonlinear equations - where Z is the number of the balls - to yield an exact solution for axial and radial deflections, and contact angles. Numerical results for a 218 angular-contact ball bearing have been compared with those from the literature and show significant differences in the magnitudes of the ball loads, contact angles, and the extent of the loading zone.

  16. Frictional torque numbers for ball cup and journal bearings

    NARCIS (Netherlands)

    Ligterink, D.J.

    1982-01-01

    Plastic bearing material wears in ball cup and journal bearings. Contact areas in the ball cup and the journal bearing increase. The frictional torque needed to rotate the ball or journal also increases. When the coefficient of friction is assumed to be constant during wearing out, the frictional t

  17. Frictional torque numbers for ball cup and journal bearings

    OpenAIRE

    Ligterink, D.J.

    1982-01-01

    Plastic bearing material wears in ball cup and journal bearings. Contact areas in the ball cup and the journal bearing increase. The frictional torque needed to rotate the ball or journal also increases. When the coefficient of friction is assumed to be constant during wearing out, the frictional torque increases to a maximum of 1.273 times the frictional torque at zero wear.

  18. 24 CFR 3285.202 - Soil classifications and bearing capacity.

    Science.gov (United States)

    2010-04-01

    ... capacity. 3285.202 Section 3285.202 Housing and Urban Development Regulations Relating to Housing and Urban... Soil classifications and bearing capacity. The soil classification and bearing capacity of the soil... bearing capacity must be determined by one or more of the following methods, unless the soil...

  19. Mechanical design problems associated with turbopump fluid film bearings

    Science.gov (United States)

    Evces, Charles R.

    1990-01-01

    Most high speed cryogenic turbopumps for liquid propulsion rocket engines currently use ball or roller contact bearings for rotor support. The operating speeds, loads, clearances, and environments of these pumps combine to make bearing wear a limiting factor on turbopump life. An example is the high pressure oxygen turbopump (HPOTP) used in the Space Shuttle Main Engine (SSME). Although the HPOTP design life is 27,000 seconds at 30,000 rpms, or approximately 50 missions, bearings must currently be replaced after 2 missions. One solution to the bearing wear problem in the HPOTP, as well as in future turbopump designs, is the utilization of fluid film bearings in lieu of continuous contact bearings. Hydrostatic, hydrodynamic, and damping seal bearings are all replacement candidates for contact bearings in rocket engine high speed turbomachinery. These three types of fluid film bearings have different operating characteristics, but they share a common set of mechanical design opportunities and difficulties. Results of research to define some of the mechanical design issues are given. Problems considered include transient strat/stop rub, non-operational rotor support, bearing wear inspection and measurement, and bearing fluid supply route. Emphasis is given to the HPOTP preburner pump (PBP) bearing, but the results are pertinent to high-speed cryogenic turbomachinery in general.

  20. Identification of dynamic properties of radial air-foil bearings

    NARCIS (Netherlands)

    Arora, V.; Hoogt, van der P.J.M.; Aarts, R.G.K.M.; Boer, de A.

    2010-01-01

    Air-foil bearings (AFBs) are self acting hydrodynamic bearings made from sheet metal foils comprised of at least two layers. The innermost “top foil” layer traps a gas pressure film that supports a load while the layer or layers underneath provide an elastic foundation. Air-foil bearings are current

  1. Temperature distribution and scuffing of tapered roller bearing

    Science.gov (United States)

    Wang, Ailin; Wang, Jiugen

    2014-11-01

    In the field of aerospace, high-speed trains and automobile, etc, analysis of temperature filed and scuffing failure of tapered roller bearings are more important than ever, and the scuffing failure of elements of such rolling bearings under heavy load and high speed still cannot be effectively predicted yet. A simplified model of tapered roller bearings consisted of one inner raceway, one outer raceway and a tapered roller was established, in which the interaction of several heat sources is ignored. The contact mechanics model, temperature model and model of scuffing failure are synthesized, and the corresponding computer programs are developed to analyze the effects of bearings parameters, different material and operational conditions on thermal performance of bearings, and temperature distribution and the possibility of surface scuffing are obtained. The results show that load, speed, thermal conductivity and tapered roller materials influence temperature rise and scuffing failure of bearings. Ceramic material of tapered roller results in the decrease of scuffing possibility of bearings to a high extent than the conventional rolling bearing steel. Compared with bulk temperature, flash temperature on the surfaces of bearing elements has a little influence on maximum temperature rise of bearing elements. For the rolling bearings operated under high speed and heavy load, this paper proposes a method which can accurately calculate the possibility of scuffing failure of rolling bearings.

  2. Trichinella surveillance in black bears (Ursus americanus) from Oregon, USA.

    Science.gov (United States)

    Mortenson, J A; Kent, M L; Fowler, D R; Chomel, B B; Immell, D A

    2014-01-01

    We used serology and muscle digestion to test black bears (Ursus americanus) from western Oregon, USA, for Trichinella. Results indicate black bears in Oregon are not part of a sylvatic cycle for Trichinella, and risk of human exposure to Trichinella larvae from eating black bear meat from Oregon appears low.

  3. 49 CFR 230.103 - Tender roller bearing journal boxes.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Tender roller bearing journal boxes. 230.103... Locomotives and Tenders Running Gear § 230.103 Tender roller bearing journal boxes. Tender roller bearing journal boxes shall be maintained in a safe and suitable condition....

  4. Identification of dynamic properties of radial air-foil bearings

    NARCIS (Netherlands)

    Arora, V.; Hoogt, van der P.J.M.; Aarts, R.G.K.M.; Boer, de A.

    2010-01-01

    Air-foil bearings (AFBs) are self acting hydrodynamic bearings made from sheet metal foils comprised of at least two layers. The innermost ‘‘top foil’’ layer traps a gas pressure film that supports a load while the layer or layers underneath provide an elastic foundation. Air-foil bearings are curre

  5. Temperature Distribution and Scuffing of Tapered Roller Bearing

    Institute of Scientific and Technical Information of China (English)

    WANG Ailin; WANG Jiugen

    2014-01-01

    In the field of aerospace, high-speed trains and automobile, etc, analysis of temperature filed and scuffing failure of tapered roller bearings are more important than ever, and the scuffing failure of elements of such rolling bearings under heavy load and high speed still cannot be effectively predicted yet. A simplified model of tapered roller bearings consisted of one inner raceway, one outer raceway and a tapered roller was established, in which the interaction of several heat sources is ignored. The contact mechanics model, temperature model and model of scuffing failure are synthesized, and the corresponding computer programs are developed to analyze the effects of bearings parameters, different material and operational conditions on thermal performance of bearings, and temperature distribution and the possibility of surface scuffing are obtained. The results show that load, speed, thermal conductivity and tapered roller materials influence temperature rise and scuffing failure of bearings. Ceramic material of tapered roller results in the decrease of scuffing possibility of bearings to a high extent than the conventional rolling bearing steel. Compared with bulk temperature, flash temperature on the surfaces of bearing elements has a little influence on maximum temperature rise of bearing elements. For the rolling bearings operated under high speed and heavy load, this paper proposes a method which can accurately calculate the possibility of scuffing failure of rolling bearings.

  6. Alternative solvent-based methyl benzoate vortex-assisted dispersive liquid-liquid microextraction for the high-performance liquid chromatographic determination of benzimidazole fungicides in environmental water samples.

    Science.gov (United States)

    Santaladchaiyakit, Yanawath; Srijaranai, Supalax

    2014-11-01

    Vortex-assisted dispersive liquid-liquid microextraction using methyl benzoate as an alternative extraction solvent for extracting and preconcentrating three benzimidazole fungicides (i.e., carbendazim, thiabendazole, and fluberidazole) in environmental water samples before high-performance liquid chromatographic analysis has been developed. The selected microextraction conditions were 250 μL of methyl benzoate containing 300 μL of ethanol, 1.0% w/v sodium acetate, and vortex agitation speed of 2100 rpm for 30 s. Under optimum conditions, preconcentration factors were 14.5-39.0 for the target fungicides. Limits of detection were obtained in the range of 0.01-0.05 μg/L. The proposed method was then applied to surface water samples and the recovery evaluations at three spiked concentration levels of 5, 30, and 50 μg/L were obtained in the range of 77.4-110.9% with the relative standard deviation water samples.

  7. Tribology experiment. [journal bearings and liquid lubricants

    Science.gov (United States)

    Wall, W. A.

    1981-01-01

    A two-dimensional concept for Spacelab rack 7 was developed to study the interaction of liquid lubricants and surfaces under static and dynamic conditions in a low-gravity environment fluid wetting and spreading experiments of a journal bearing experiments, and means to accurately measure and record the low-gravity environment during experimentation are planned. The wetting and spreading process of selected commercial lubricants on representative surface are to the observes in a near-zero gravity environment.

  8. Thermal conductivity of hydrate-bearing sediments

    Science.gov (United States)

    Cortes, Douglas D.; Martin, Ana I.; Yun, Tae Sup; Francisca, Franco M.; Santamarina, J. Carlos; Ruppel, Carolyn

    2009-11-01

    A thorough understanding of the thermal conductivity of hydrate-bearing sediments is necessary for evaluating phase transformation processes that would accompany energy production from gas hydrate deposits and for estimating regional heat flow based on the observed depth to the base of the gas hydrate stability zone. The coexistence of multiple phases (gas hydrate, liquid and gas pore fill, and solid sediment grains) and their complex spatial arrangement hinder the a priori prediction of the thermal conductivity of hydrate-bearing sediments. Previous studies have been unable to capture the full parameter space covered by variations in grain size, specific surface, degree of saturation, nature of pore filling material, and effective stress for hydrate-bearing samples. Here we report on systematic measurements of the thermal conductivity of air dry, water- and tetrohydrofuran (THF)-saturated, and THF hydrate-saturated sand and clay samples at vertical effective stress of 0.05 to 1 MPa (corresponding to depths as great as 100 m below seafloor). Results reveal that the bulk thermal conductivity of the samples in every case reflects a complex interplay among particle size, effective stress, porosity, and fluid-versus-hydrate filled pore spaces. The thermal conductivity of THF hydrate-bearing soils increases upon hydrate formation although the thermal conductivities of THF solution and THF hydrate are almost the same. Several mechanisms can contribute to this effect including cryogenic suction during hydrate crystal growth and the ensuing porosity reduction in the surrounding sediment, increased mean effective stress due to hydrate formation under zero lateral strain conditions, and decreased interface thermal impedance as grain-liquid interfaces are transformed into grain-hydrate interfaces.

  9. Low-Wear Ball-Bearing Separator

    Science.gov (United States)

    Hawkinson, Elden L.

    1991-01-01

    Proposed ball-bearing separator for use in cryogenic pump stronger and more resistant to wear. Consists of molded plastic-and-metal composite ring imbued with solid lubricant and containing embedded metal ring. Obtains combination of strength and lubricity. Before molding and machining, ring includes tooling portion for handling and indexing. Molded composite blend of PTFE and fluorinated ethylene/propylene (FEP) filled with brass and bronze powder and molybdenum disulfide powder.

  10. Thermal conductivity of hydrate-bearing sediments

    Science.gov (United States)

    Cortes, D.D.; Martin, A.I.; Yun, T.S.; Francisca, F.M.; Santamarina, J.C.; Ruppel, C.

    2009-01-01

    A thorough understanding of the thermal conductivity of hydrate-bearing sediments is necessary for evaluating phase transformation processes that would accompany energy production from gas hydrate deposits and for estimating regional heat flow based on the observed depth to the base of the gas hydrate stability zone. The coexistence of multiple phases (gas hydrate, liquid and gas pore fill, and solid sediment grains) and their complex spatial arrangement hinder the a priori prediction of the thermal conductivity of hydrate-bearing sediments. Previous studies have been unable to capture the full parameter space covered by variations in grain size, specific surface, degree of saturation, nature of pore filling material, and effective stress for hydrate-bearing samples. Here we report on systematic measurements of the thermal conductivity of air dry, water- and tetrohydrofuran (THF)-saturated, and THF hydrate-saturated sand and clay samples at vertical effective stress of 0.05 to 1 MPa (corresponding to depths as great as 100 m below seafloor). Results reveal that the bulk thermal conductivity of the samples in every case reflects a complex interplay among particle size, effective stress, porosity, and fluid-versus-hydrate filled pore spaces. The thermal conductivity of THF hydrate-bearing soils increases upon hydrate formation although the thermal conductivities of THF solution and THF hydrate are almost the same. Several mechanisms can contribute to this effect including cryogenic suction during hydrate crystal growth and the ensuing porosity reduction in the surrounding sediment, increased mean effective stress due to hydrate formation under zero lateral strain conditions, and decreased interface thermal impedance as grain-liquid interfaces are transformed into grain-hydrate interfaces. Copyright 2009 by the American Geophysical Union.

  11. Concurrent initialization for Bearing-Only SLAM.

    Science.gov (United States)

    Munguía, Rodrigo; Grau, Antoni

    2010-01-01

    Simultaneous Localization and Mapping (SLAM) is perhaps the most fundamental problem to solve in robotics in order to build truly autonomous mobile robots. The sensors have a large impact on the algorithm used for SLAM. Early SLAM approaches focused on the use of range sensors as sonar rings or lasers. However, cameras have become more and more used, because they yield a lot of information and are well adapted for embedded systems: they are light, cheap and power saving. Unlike range sensors which provide range and angular information, a camera is a projective sensor which measures the bearing of images features. Therefore depth information (range) cannot be obtained in a single step. This fact has propitiated the emergence of a new family of SLAM algorithms: the Bearing-Only SLAM methods, which mainly rely in especial techniques for features system-initialization in order to enable the use of bearing sensors (as cameras) in SLAM systems. In this work a novel and robust method, called Concurrent Initialization, is presented which is inspired by having the complementary advantages of the Undelayed and Delayed methods that represent the most common approaches for addressing the problem. The key is to use concurrently two kinds of feature representations for both undelayed and delayed stages of the estimation. The simulations results show that the proposed method surpasses the performance of previous schemes.

  12. How Many Ore-Bearing Asteroids?

    CERN Document Server

    Elvis, Martin

    2013-01-01

    A simple formalism is presented to assess how many asteroids contain ore, i.e. commercially profitable material, and not merely a high concentration of a resource. I apply this formalism to two resource cases: platinum group metals (PGMs) and water. Assuming for now that only Ni-Fe asteroids are of interest for PGMs, then 1% of NEOs are rich in PGMs. The dearth of ultra-low delta-v (= US$1 B and the population of near-Earth objects (NEOs) larger than 100 m diameter is ~20,000 (Mainzer et al. 2011) the total population of PGM ore-bearing NEOs is roughly 10. I stress that this is a conservative and highly uncertain value. For example, an order of magnitude increase in PGM ore-bearing NEOs occurs if delta-v can as large as 5.7 km s-1. Water ore for utilization in space is likely to be found in ~1/1100 NEOs. NEOs as small as 18 m diameter can be water-ore-bodies because of the high richness of water (~20%) expected in ~25% of carbonaceous asteroids, bringing the number of water-ore-bearing NEOs to ~9000 out of th...

  13. AN INVESTIGATION OF MAGNETIC BEARING SYSTEMS

    Directory of Open Access Journals (Sweden)

    Gürcan SAMTAŞ

    2007-02-01

    Full Text Available The magnetic bearing consists of levitating a shaft so that it is free to rotate about its axis. The magnetic bearing has the advantages of being very quiet work and very cleanliness because there is no mechanical friction or lubricants. The shaft has two permanent magnets attached to it. These two magnets determine a straight line rotation axis of the rotor shaft. The magnets are radially levitated and centered within a cavity by a passive permanent magnetic field in the adding stator housing assembly. The levitation and centering of the shaft axially is stabilized by a closed loop electronic servo circuit that regulates an electromagnetic field in the stator housing that pushes and pulls on the shaft magnets. The rotor weight can be between one gram and forty five thousand, four hundred grams. In 1985, the first magnetic bearing was developed that it had used to applications of gas turbines and other compressors. In these days, they can be used by many applications which are Medical, Transportation, Machine and Tools Industry, Aerospace, Vacuum and Clean room Environments... etc.

  14. Concurrent Initialization for Bearing-Only SLAM

    Directory of Open Access Journals (Sweden)

    Antoni Grau

    2010-03-01

    Full Text Available Simultaneous Localization and Mapping (SLAM is perhaps the most fundamental problem to solve in robotics in order to build truly autonomous mobile robots. The sensors have a large impact on the algorithm used for SLAM. Early SLAM approaches focused on the use of range sensors as sonar rings or lasers. However, cameras have become more and more used, because they yield a lot of information and are well adapted for embedded systems: they are light, cheap and power saving. Unlike range sensors which provide range and angular information, a camera is a projective sensor which measures the bearing of images features. Therefore depth information (range cannot be obtained in a single step. This fact has propitiated the emergence of a new family of SLAM algorithms: the Bearing-Only SLAM methods, which mainly rely in especial techniques for features system-initialization in order to enable the use of bearing sensors (as cameras in SLAM systems. In this work a novel and robust method, called Concurrent Initialization, is presented which is inspired by having the complementary advantages of the Undelayed and Delayed methods that represent the most common approaches for addressing the problem. The key is to use concurrently two kinds of feature representations for both undelayed and delayed stages of the estimation. The simulations results show that the proposed method surpasses the performance of previous schemes.

  15. Effects of sodium benzoate on liver and kidney in rats%苯甲酸钠多次给药对大鼠肝肾功能的影响

    Institute of Scientific and Technical Information of China (English)

    李锦玉; 李荣欣; 李京路; 毕红征

    2015-01-01

    目的:研究食品防腐剂苯甲酸钠多次给药对大鼠肝肾功能的影响。方法:选取50只健康SPF级SD大鼠,分为5组,每组10只,苯甲酸钠低、中、高剂量组分别灌胃给予苯甲酸钠(0.1、0.2、0.4 g/kg),阳性对照组给予山梨酸钾(0.2 g/kg),空白对照组给予生理盐水,1次/d,连续4周。检测末次给药后大鼠血清学指标(ALT、AST、ALP、GGT、TP、ALB、TBIL、BUN、Cre、UA),并观察肝肾组织病理学改变。结果:与空白对照组相比,苯甲酸钠低、中、高剂量组大鼠的各项血清生化学指标均有一定的异常,高剂量组最为显著(P均<0.05)。苯甲酸钠高剂量组大鼠肝脏出现了明显病理学异常,各组大鼠肾脏均未见病理学改变。结论:苯甲酸钠多次给药对大鼠肝肾,尤其是肝脏有一定的损害。%Aim:To study the effects of sodium benzoate on liver and kidney in rats .Methods: Fifty healthy SD rats were allocated into 5 groups and treated with sodium benzoate (0.1,0.2,0.4 g/kg),potassium sorbate(0.2 g/kg) and normal saline by gavage for 4 weeks.The serum indicators such as ALT , AST, ALP, GGT, TP, ALB, TBIL, BUN,Cre, and UA were determined and the liver and renal histology of the rats was observed .Results:Rats in each dose group of sodium ben-zoate had abnormal serum biochemical indicators , especially in high dose group .Furthermore, rats in sodium benzoate high dose group showed obvious pathological abnormalities in liver .Rats in all groups showed no pathological changes in kidneys . Conclusion:The frequent use of sodium benzoate could do harms to the kidney and liver especially to the liver in rats .

  16. Conflict bear translocation: investigating population genetics and fate of bear translocation in Dachigam National Park, Jammu and Kashmir, India.

    Science.gov (United States)

    Mukesh; Sharma, Lalit Kumar; Charoo, Samina Amin; Sathyakumar, Sambandam

    2015-01-01

    The Asiatic black bear population in Dachigam landscape, Jammu and Kashmir is well recognized as one of the highest density bear populations in India. Increasing incidences of bear-human interactions and the resultant retaliatory killings by locals have become a serious threat to the survivorship of black bears in the Dachigam landscape. The Department of Wildlife Protection in Jammu and Kashmir has been translocating bears involved in conflicts, henceforth 'conflict bears' from different sites in Dachigam landscape to Dachigam National Park as a flagship activity to mitigate conflicts. We undertook this study to investigate the population genetics and the fate of bear translocation in Dachigam National Park. We identified 109 unique genotypes in an area of ca. 650 km2 and observed bear population under panmixia that showed sound genetic variability. Molecular tracking of translocated bears revealed that mostly bears (7 out of 11 bears) returned to their capture sites, possibly due to homing instincts or habituation to the high quality food available in agricultural croplands and orchards, while only four bears remained in Dachigam National Park after translocation. Results indicated that translocation success was most likely to be season dependent as bears translocated during spring and late autumn returned to their capture sites, perhaps due to the scarcity of food inside Dachigam National Park while bears translocated in summer remained in Dachigam National Park due to availability of surplus food resources. Thus, the current management practices of translocating conflict bears, without taking into account spatio-temporal variability of food resources in Dachigam landscape seemed to be ineffective in mitigating conflicts on a long-term basis. However, the study highlighted the importance of molecular tracking of bears to understand their movement patterns and socio-biology in tough terrains like Dachigam landscape.

  17. Gas Foil Bearing Misalignment and Unbalance Effects

    Science.gov (United States)

    Howard, Samuel A.

    2008-01-01

    The effects of misalignment and unbalance on gas foil bearings are presented. The future of U.S. space exploration includes plans to conduct science missions aboard space vehicles, return humans to the Moon, and place humans on Mars. All of these endeavors are of long duration, and require high amounts of electrical power for propulsion, life support, mission operations, etc. One potential source of electrical power of sufficient magnitude and duration is a nuclear-fission-based system. The system architecture would consist of a nuclear reactor heat source with the resulting thermal energy converted to electrical energy through a dynamic power conversion and heat rejection system. Various types of power conversion systems can be utilized, but the Closed Brayton Cycle (CBC) turboalternator is one of the leading candidates. In the CBC, an inert gas heated by the reactor drives a turboalternator, rejects excess heat to space through a heat exchanger, and returns to the reactor in a closed loop configuration. The use of the CBC for space power and propulsion is described in more detail in the literature (Mason, 2003). In the CBC system just described, the process fluid is a high pressure inert gas such as argon, krypton, or a helium-xenon mixture. Due to the closed loop nature of the system and the associated potential for damage to components in the system, contamination of the working fluid is intolerable. Since a potential source of contamination is the lubricant used in conventional turbomachinery bearings, Gas Foil Bearings (GFB) have high potential for the rotor support system. GFBs are compliant, hydrodynamic journal and thrust bearings that use a gas, such as the CBC working fluid, as their lubricant. Thus, GFBs eliminate the possibility of contamination due to lubricant leaks into the closed loop system. Gas foil bearings are currently used in many commercial applications, both terrestrial and aerospace. Aircraft Air Cycle Machines (ACMs) and ground

  18. Development of small bore, high speed tapered roller bearing

    Science.gov (United States)

    Morrison, F. R.; Gassel, S. S.; Bovenkerk, R. L.

    1981-01-01

    The performance of four rolling bearing configurations for use on the input pinion shaft of a proposed commercial helicopter transmission was evaluated. The performance characteristics of a high speed tapered roller bearing operating under conditions comparable to those existing at this input pinion shaft were defined. The tapered roller bearing shaft support configuration was developed for the gearbox using commercially available bearing designings. The configuration was optimized and interactive thermomechanically system analyzed. Automotive pinion quality tapered roller bearings were found to be reliable under load and speed conditions in excess of those anticipated in the helicopter transmission. However, it is indicated that the elastohydrodynamic lubricant films are inadequate.

  19. Shaft centre orbit for dynamically loaded radial bearings

    DEFF Research Database (Denmark)

    Klit, Peder; Vølund, Anders

    2002-01-01

    The aim of this work is to demonstrate how to utilize the bearings damping coefficients to estimate the orbit for a dynamically loaded journal bearing. The classical method for this analysis was developed by Booker in 1965 Booker1 and described further in 1972 Booker2. Several authors have refined...... seventies Jorgen W. Lund pointed out in lecture notes that the dynamic damping coefficients of the bearing could be used to find the shaft orbit for dynamically loaded bearings. For simplicity the "Short-Width-Journal-Bearing Theory" is used as a basis for finding the damping coefficients in this work...

  20. Relationship of rolling bearing stiffness with diameter of roller

    Institute of Scientific and Technical Information of China (English)

    郭茂林; 王刚; 张瑞

    2002-01-01

    The theoretical formula of roller bearing stiffness is induced and compared with its empirical formula.In the experience formula the stiffness of roller bearing has nothing to do with the roller diameter. The relation-ship of roller bearing stiffness with roller diameter was studied using Hz contacting theory. It is concluded thatconclusion in experience formula is only approximate result of data processing under special conditions, and therelation between stiffness of roller bearing and roller diameter must be taken into consideration while designingor selecting roller bearings.

  1. Potential energetic effects of mountain climbers on foraging grizzly bears

    Science.gov (United States)

    White, D.; Kendall, K.C.; Picton, H.D.

    1999-01-01

    Most studies of the effects of human disturbance on grizzly bears (Ursus arctos horribilis) have not quantified the energetic effects of such interactions. In this study, we characterized activity budgets of adult grizzly bears as they foraged on aggregations of adult army cutworm moths (Euxoa auxiliaris) in the alpine of Glacier National Park, Montana, during 1992, 1994, and 1995. We compared the activity budgets of climber-disturbed bears to those of undisturbed bears to estimate the energetic impact of climber disturbance. When bears detected climbers, they subsequently spent 53% less time foraging on moths, 52% more time moving within the foraging area, and 23% more time behaving aggressively, compared to when they were not disturbed. We estimated that grizzly bears could consume approximately 40,000 moths/day or 1,700 moths/hour. At 0.44 kcal/moth, disruption of moth feeding cost bears approximately 12 kcal/minute in addition to the energy expended in evasive maneuvers and defensive behaviors. To reduce both climber interruption of bear foraging and the potential for aggressive bear-human encounters, we recommend routing climbers around moth sites used by bears or limiting access to these sites during bear-use periods.

  2. Physiologic responses of grizzly bears to different methods of capture.

    Science.gov (United States)

    Cattet, Marc R; Christison, Katina; Caulkett, Nigel A; Stenhouse, Gordon B

    2003-07-01

    The physiologic effects of two methods of capture, chemical immobilization of free-ranging (FR) bears by remote injection from a helicopter and physical restraint (PR) by leg-hold snare prior to chemical immobilization, were compared in 46 grizzly bears (Ursus arctos) handled during 90 captures between 1999 and 2001. Induction dosages and times were greater for FR bears than PR bears, a finding consistent with depletion of, or decreased sensitivity to, catecholamines. Free-ranging bears also had higher rectal temperatures 15 min following immobilization and temperatures throughout handling that correlated positively with induction time. Physically restrained bears had higher white blood cell counts, with more neutrophils and fewer lymphocytes and eosinophils, than did FR bears. This white blood cell profile was consistent with a stress leukogram, possibly affected by elevated levels of serum cortisol. Serum concentrations of alanine aminotransferase, aspartate aminotransferase, and creatine kinase were higher in PR bears that suggested muscle injury. Serum concentrations of sodium and chloride also were higher in PR bears and attributed to reduced body water volume through water deprivation and increased insensible water loss. Overall, different methods of capture resulted in different patterns of physiologic disturbance. Reducing pursuit and drug induction times should help to minimize increase in body temperature and alteration of acid-base balance in bears immobilized by remote injection. Minimizing restraint time and ensuring snare-anchoring cables are short should help to minimize loss of body water and prevent serious muscle injury in bears captured by leg-hold snare.

  3. Rolling Bearing Steels - A Technical and Historical Perspective

    Science.gov (United States)

    Zaretsky, Erwin V.

    2012-01-01

    Starting about 1920 it becomes easier to track the growth of bearing materials technology. Until 1955, with few exceptions, comparatively little progress was made in this area. AISI 52100 and some carburizing grades (AISI 4320, AISI 9310) were adequate for most applications. The catalyst to quantum advances in high-performance rolling-element bearing steels was the advent of the aircraft gas turbine engine. With improved bearing manufacturing and steel processing together with advanced lubrication technology, the potential improvements in bearing life can be as much as 80 times that attainable in the late 1950s or as much as 400 times that attainable in 1940. This paper summarizes the chemical, metallurgical and physical aspects of bearing steels and their effect on rolling bearing life and reliability. The single most important variable that has significantly increased bearing life and reliability is vacuum processing of bearing steel. Differences between through hardened, case carburized and corrosion resistant steels are discussed. The interrelation of alloy elements and carbides and their effect on bearing life are presented. An equation relating bearing life, steel hardness and temperature is given. Life factors for various steels are suggested and discussed. A relation between compressive residual stress and bearing life is presented. The effects of retained austenite and grain size are discussed.

  4. Analysis of thermoelastohydrodynamic performance of journal misaligned engine main bearings

    Science.gov (United States)

    Bi, Fengrong; Shao, Kang; Liu, Changwen; Wang, Xia; Zhang, Jian

    2015-05-01

    To understand the engine main bearings' working condition is important in order to improve the performance of engine. However, thermal effects and thermal effect deformations of engine main bearings are rarely considered simultaneously in most studies. A typical finite element model is selected and the effect of thermoelastohydrodynamic(TEHD) reaction on engine main bearings is investigated. The calculated method of main bearing's thermal hydrodynamic reaction and journal misalignment effect is finite difference method, and its deformation reaction is calculated by using finite element method. The oil film pressure is solved numerically with Reynolds boundary conditions when various bearing characteristics are calculated. The whole model considers a temperature-pressure-viscosity relationship for the lubricant, surface roughness effect, and also an angular misalignment between the journal and the bearing. Numerical simulations of operation of a typical I6 diesel engine main bearing is conducted and importance of several contributing factors in mixed lubrication is discussed. The performance characteristics of journal misaligned main bearings under elastohydrodynamic(EHD) and TEHD loads of an I6 diesel engine are received, and then the journal center orbit movement, minimum oil film thickness and maximum oil film pressure of main bearings are estimated over a wide range of engine operation. The model is verified through the comparison with other present models. The TEHD performance of engine main bearings with various effects under the influences of journal misalignment is revealed, this is helpful to understand EHD and TEHD effect of misaligned engine main bearings.

  5. Effects of exotic species on Yellowstone's grizzly bears

    Science.gov (United States)

    Reinhart, D.P.; Haroldson, Mark A.; Mattson, D.J.; Gunther, Kerry A.

    2001-01-01

    Humans have affected grizzly bears (Ursus arctos horribilis) by direct mortality, competition for space and resources, and introduction of exotic species. Exotic organisms that have affected grizzly bears in the Greater Yellowstone Area include common dandelion (Taraxacum officinale), nonnative clovers (Trifolium spp.), domesticated livestock, bovine brucellosis (Brucella abortus), lake trout (Salvelinus namaycush), and white pine blister rust (Cronartium ribicola). Some bears consume substantial amounts of dandelion and clover. However, these exotic foods provide little digested energy compared to higher-quality bear foods. Domestic livestock are of greater energetic value, but use of this food by bears often leads to conflicts with humans and subsequent increases in bear mortality. Lake trout, blister rust, and brucellosis diminish grizzly bears foods. Lake trout prey on native cutthroat trout (Oncorhynchus clarkii) in Yellowstone Lake; white pine blister rust has the potential to destroy native whitebark pine (Pinus albicaulis) stands; and management response to bovine brucellosis, a disease found in the Yellowstone bison (Bison bison) and elk (Cervus elaphus), could reduce populations of these 2 species. Exotic species will likely cause more harm than good for Yellowstone grizzly bears. Managers have few options to mitigate or contain the impacts of exotics on Yellowstones grizzly bears. Moreover, their potential negative impacts have only begun to unfold. Exotic species may lead to the loss of substantial highquality grizzly bear foods, including much of the bison, trout, and pine seeds that Yellowstone grizzly bears currently depend upon.

  6. Misalignment in Gas Foil Journal Bearings: An Experimental Study

    Science.gov (United States)

    Howard, Samuel A.

    2008-01-01

    As gas foil journal bearings become more prevalent in production machines, such as small gas turbine propulsion systems and microturbines, system-level performance issues must be identified and quantified in order to provide for successful design practices. Several examples of system-level design parameters that are not fully understood in foil bearing systems are thermal management schemes, alignment requirements, balance requirements, thrust load balancing, and others. In order to address some of these deficiencies and begin to develop guidelines, this paper presents a preliminary experimental investigation of the misalignment tolerance of gas foil journal bearing systems. Using a notional gas foil bearing supported rotor and a laser-based shaft alignment system, increasing levels of misalignment are imparted to the bearing supports while monitoring temperature at the bearing edges. The amount of misalignment that induces bearing failure is identified and compared to other conventional bearing types such as cylindrical roller bearings and angular contact ball bearings. Additionally, the dynamic response of the rotor indicates that the gas foil bearing force coefficients may be affected by misalignment.

  7. Ethyl 2-[(azidocarbonylamino]benzoate

    Directory of Open Access Journals (Sweden)

    Hasna Yassine

    2016-07-01

    Full Text Available In the almost planar (r.m.s. deviation = 0.038 Å title compound, C10H10N4O3, an intramolecular N—H...O interaction closes an S(6 ring. In the crystal, aromatic π–π stacking interactions occur [inter-centroid distance = 3.65 (2 Å].

  8. Butyl 2-[(azidocarbonylamino]benzoate

    Directory of Open Access Journals (Sweden)

    Hasna Yassine

    2016-09-01

    Full Text Available The title compound, C12H14N4O3, is planar with an r.m.s deviation of 0.025 Å from the plane through all 19 non-hydrogen atoms. An intramolecular N—H...O interaction closes an S(6 ring. In the crystal, molecules are linked by C—H...π and weak offset π–π stacking interactions [inter-centroid distance = 3.614 (2 Å], forming undulating sheets parallel to (001.

  9. Cyclostationary Analysis for Gearbox and Bearing Fault Diagnosis

    Directory of Open Access Journals (Sweden)

    Zhipeng Feng

    2015-01-01

    Full Text Available Gearbox and rolling element bearing vibration signals feature modulation, thus being cyclostationary. Therefore, the cyclic correlation and cyclic spectrum are suited to analyze their modulation characteristics and thereby extract gearbox and bearing fault symptoms. In order to thoroughly understand the cyclostationarity of gearbox and bearing vibrations, the explicit expressions of cyclic correlation and cyclic spectrum for amplitude modulation and frequency modulation (AM-FM signals are derived, and their properties are summarized. The theoretical derivations are illustrated and validated by gearbox and bearing experimental signal analyses. The modulation characteristics caused by gearbox and bearing faults are extracted. In faulty gearbox and bearing cases, more peaks appear in cyclic correlation slice of 0 lag and cyclic spectrum, than in healthy cases. The gear and bearing faults are detected by checking the presence or monitoring the magnitude change of peaks in cyclic correlation and cyclic spectrum and are located according to the peak cyclic frequency locations or sideband frequency spacing.

  10. Computer-aided selection of materials for cryogenic turbopump bearings

    Science.gov (United States)

    Maurer, R. E.; Pallini, R. A.

    1985-01-01

    The life requirement for the angular contact ball bearings in the Space Shuttle Main Engine (SSME) high-pressure-oxygen turbopump (HPOTP) is 7.5 hours. In actual operation, significantly shorter service life has been experienced. The objective of this current program is to identify bearing materials and/or materials processing techniques offering significant potential for extending HPOTP bearing performance life. A thermomechanical analysis of the HPOTP shaft/bearing system was performed with the SHABERTH (SHaft-BEaring-THermal) computer program. Bearing fatigue life, ball-race contact stress, heat generation rate, bulk ring temperatures, and circumferential stress in the inner rings were quantified as functions of radial load, thrust load, and ball-race contact friction. The analysis results were used to formulate criteria that are being used for the selection of special materials for future turbopump bearings.

  11. Marshall Space Flight Center High Speed Turbopump Bearing Test Rig

    Science.gov (United States)

    Gibson, Howard; Moore, Chip; Thom, Robert

    2000-01-01

    The Marshall Space Flight Center has a unique test rig that is used to test and develop rolling element bearings used in high-speed cryogenic turbopumps. The tester is unique in that it uses liquid hydrogen as the coolant for the bearings. This test rig can simulate speeds and loads experienced in the Space Shuttle Main Engine turbopumps. With internal modifications, the tester can be used for evaluating fluid film, hydrostatic, and foil bearing designs. At the present time, the test rig is configured to run two ball bearings or a ball and roller bearing, both with a hydrostatic bearing. The rig is being used to evaluate the lifetimes of hybrid bearings with silicon nitride rolling elements and steel races.

  12. Vascular injuries after bear attacks: Incidence, surgical challenges and outcome

    Directory of Open Access Journals (Sweden)

    Wani Mohd

    2011-01-01

    Full Text Available Background : Bear mauling is rarely reported in medical literature due to its rare occurrence. Present study was undertaken to describe the pattern and management of bear maul vascular injuries in Kashmir. Methods : Study of patients with bear maul vascular injury from 1st Jan 2004 to 31st Dec. 2008. Fifteen patients with bear maul vascular injury were studied. All patients of bear maul without vascular injury were excluded from the study. Results : Most of the patients were treated by reverse saphenous vein graft or end to end anastomosis. Most common complication was wound infection (20% followed by graft occlusion (13.33%. There was no operative death. Conclusion : Bear attacks are very common in Kashmir. Vascular injury due to bear maul needs prompt resuscitation and revascularization. Results are very good provided timely intervention for revascularization is done.

  13. Effect of fluid compressibility on journal bearing performance

    Energy Technology Data Exchange (ETDEWEB)

    Dimofte, F. (NASA, Lewis Research Center, Cleveland, OH (United States))

    1993-07-01

    An analysis was undertaken to determine the effect of fluid film compressibility on the performance of fluid film bearings. A new version of the Reynolds equation was developed, using a polytropic expansion, for both steady-state and dynamic conditions. Polytropic exponents from 1 (isothermal) to 1000 (approaching an incompressible liquid) were evaluated for two bearing numbers, selected from a range of practical interest for cryogenic application, and without cavitation. Bearing loads were insensitive to fluid compressibility for low bearing numbers, as was expected. The effect of compressibility on attitude angle was significant, even when the bearing number was low. A small amount of fluid compressibility was enough to obtain stable running conditions. Incompressible liquid lacked stability at all conditions. Fluid compressibility can be used to control the bearing dynamic coefficients, thereby influencing the dynamic behavior of the rotor-bearing system. 14 refs.

  14. Vibration transmission through rolling element bearings. I - Bearing stiffness formulation. II - System studies

    Science.gov (United States)

    Lim, T. C.; Singh, R.

    1990-01-01

    How vibratory motion can be transmitted from the rotating shaft to the casing and other connecting structures in rotating mechanical equipment is addressed here by developing a new mathematical model of precision rolling element bearings. A new grating stiffness matrix is proposed in order to demonstrate a coupling between the shaft bending motion and the flexural motion of the casing plate. It is shown that the translational bearing stiffness coefficients currently used in rotor dynamic models are a small subset of the proposed matrix. The theory is validated by examples, and the proposed bearing formulation is then extended to demonstrate its superiority over existing models in vibration transmission analyses. It is shown that the model can easily be incorporated into analytical or numerical models typically used for dynamic analyses.

  15. Condition monitoring of induction motor bearing based on bearing damage index

    Directory of Open Access Journals (Sweden)

    Patel R.K.

    2017-03-01

    Full Text Available The rolling element bearings are used broadly in many machinery applications. It is used to support the load and preserve the clearance between stationary and rotating machinery elements. Unfortunately, rolling element bearings are exceedingly prone to premature failures. Vibration signal analysis has been widely used in the faults detection of rotating machinery and can be broadly classified as being a stationary or non-stationary signal. In the case of the faulty rolling element bearing the vibration signal is not strictly phase locked to the rotational speed of the shaft and become “transient” in nature. The purpose of this paper is to briefly discuss the identification of an Inner Raceway Fault (IRF and an Outer Raceway Fault (ORF with the different fault severity levels. The conventional statistical analysis was only able to detect the existence of a fault but unable to discriminate between IRF and ORF. In the present work, a detection technique named as bearing damage index (BDI has been proposed. The proposed BDI technique uses wavelet packet node energy coefficient analysis method. The well-known combination of Hilbert transform (HT and Fast Fourier Transform (FFT has been carried out in order to identify the IRF and ORF faults. The results show that wavelet packet node energy coefficients are not only sensitive to detect the faults in bearing but at the same time they are able to detect the severity level of the fault. The proposed bearing damage index method for fault identification may be considered as an ‘index’ representing the health condition of rotating machines.

  16. Trophic cascades from wolves to grizzly bears or changing abundance of bears and alternate foods?

    Science.gov (United States)

    Barber-Meyer, Shannon M

    2015-05-01

    This is a Forum article commenting on: Ripple, W. J., Beschta, R. L., Fortin, J. K., & Robbins, C. T. (2014) Trophic cascades from wolves to grizzly bears in Yellowstone. Journal of Animal Ecology, 83, 223-233. Comparisons Ripple et al. (2014) used to demonstrate increased fruit availability and consumption by grizzly bears post-wolf reintroduction are flawed and tenuous at best. Importantly, a more parsimonious (than trophic cascades) hypothesis, not sufficiently considered by Ripple et al., exists and is better supported by available data I review.

  17. Performance of passive target tracking using bearing-frequency and bearings of multiple arrays

    Institute of Scientific and Technical Information of China (English)

    DU Xuanmin; YAO Lan

    2002-01-01

    Two target motion analysis (TMA) methods using multi-dimension information are studied, one is TMA with bearing-frequency and the other is TMA with multiple arrays. The optimization algorithm combining Gauss-Newton (G-N) method with Levenberg-Marquardt(LM) method is applied to analyze the performance of target tracking with maximum likelihood estimation(MLE), and Monte Carlo experiments are presented. The results show that although the TMA with multi-dimension information have eliminated the maneuvers needed by conventional bearing-only TMA, but the application are not of universality.

  18. Serologic survey of Toxoplasma gondii in grizzly bears (Ursus arctos) and black bears (Ursus americanus), from Alaska, 1988 to 1991.

    Science.gov (United States)

    Chomel, B B; Zarnke, R L; Kasten, R W; Kass, P H; Mendes, E

    1995-10-01

    We tested 644 serum samples from 480 grizzly bears and 40 black bears from Alaska (USA), collected between 1988 and 1991, for Toxoplasma gondii antibodies, using a commercially available latex agglutination test (LAT). A titer > or = 64 was considered positive. Serum antibody prevalence for T. gondii in grizzly bears (Ursus arctos) was 18% (87 of 480). Prevalence ranged from 9% (seven of 77) on Kodiak Island to 28% (15 of 54) in northern Alaska. Prevalence was directly correlated to age. No grizzly bears grizzly bears captured north of the Arctic Circle. Antibody prevalence in black bears (Ursus americanus) from Interior Alaska was 15% (six of 40), similar to the prevalence in grizzly bears from the same area (13%; five of 40).

  19. Method of recertifying a loaded bearing member

    Science.gov (United States)

    Allison, Sidney G. (Inventor)

    1992-01-01

    A method is described of recertifying a loaded bearing member using ultrasound testing to compensate for different equipment configurations and temperature conditions. The standard frequency F1 of a reference block is determined via an ultrasonic tone burst generated by a first pulsed phased locked loop (P2L2) equipment configuration. Once a lock point number S is determined for F1, the reference frequency F1a of the reference block is determined at this lock point number via a second P2L2 equipment configuration to permit an equipment offset compensation factor Fo1=((F1-F1a)/F1)(1000000) to be determined. Next, a reference frequency F2 of the unloaded bearing member is determined using a second P2L2 equipment configuration and is then compensated for equipment offset errors via the relationship F2+F2(Fo1)/1000000. A lock point number b is also determined for F2. A resonant frequency F3 is determined for the reference block using a third P2L2 equipment configuration to determine a second offset compensation factor F02=((F1-F3)/F1) 1000000. Next the resonant frequency F4 of the loaded bearing member is measured at lock point number b via the third P2L2 equipment configuration and the bolt load determined by the relationship (-1000000)CI(((F2-F4)/F2)-Fo2), wherein CI is a factor correlating measured frequency shift to the applied load. Temperature compensation is also performed at each point in the process.

  20. Performance of ceramic superconductors in magnetic bearings

    Science.gov (United States)

    Kirtley, James L., Jr.; Downer, James R.

    1993-01-01

    Magnetic bearings are large-scale applications of magnet technology, quite similar in certain ways to synchronous machinery. They require substantial flux density over relatively large volumes of space. Large flux density is required to have satisfactory force density. Satisfactory dynamic response requires that magnetic circuit permeances not be too large, implying large air gaps. Superconductors, which offer large magnetomotive forces and high flux density in low permeance circuits, appear to be desirable in these situations. Flux densities substantially in excess of those possible with iron can be produced, and no ferromagnetic material is required. Thus the inductance of active coils can be made low, indicating good dynamic response of the bearing system. The principal difficulty in using superconductors is, of course, the deep cryogenic temperatures at which they must operate. Because of the difficulties in working with liquid helium, the possibility of superconductors which can be operated in liquid nitrogen is thought to extend the number and range of applications of superconductivity. Critical temperatures of about 98 degrees Kelvin were demonstrated in a class of materials which are, in fact, ceramics. Quite a bit of public attention was attracted to these new materials. There is a difficulty with the ceramic superconducting materials which were developed to date. Current densities sufficient for use in large-scale applications have not been demonstrated. In order to be useful, superconductors must be capable of carrying substantial currents in the presence of large magnetic fields. The possible use of ceramic superconductors in magnetic bearings is investigated and discussed and requirements that must be achieved by superconductors operating at liquid nitrogen temperatures to make their use comparable with niobium-titanium superconductors operating at liquid helium temperatures are identified.

  1. Changing Ideas About Child-Bearing

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    IN the past, embracing the idea that "more children means more happiness", rural women thought that if they bear many children, they would be better supported in their old age. So most of the elderly people in Hezhuang Village have up to seven or eigbt children. But in a village in the Linyi City district of Shandong Province, more children has not meant more happiness for parents. Wang Shixiang has four sons and two daughters. Last year, she and her husband finally paid off the debt

  2. Estimating Potential Effects of Hypothetical Oil Spills on Polar Bears

    Science.gov (United States)

    Amstrup, Steven C.; Durner, G.M.; McDonald, T.L.; Johnson, W.R.

    2006-01-01

    Much is known about the transport and fate of oil spilled into the sea and its toxicity to exposed wildlife. Previously, however, there has been no way to quantify the probability that wildlife dispersed over the seascape would be exposed to spilled oil. Polar bears, the apical predator of the arctic, are widely dispersed near the continental shelves of the Arctic Ocean, an area also undergoing considerable hydrocarbon exploration and development. We used 15,308 satellite locations from 194 radiocollared polar bears to estimate the probability that polar bears could be exposed to hypothetical oil spills. We used a true 2 dimensional Gausian kernel density estimator, to estimate the number of bears likely to occur in each 1.00 km2 cell of a grid superimposed over near shore areas surrounding 2 oil production facilities: the existing Northstar oil production facility, and the proposed offshore site for the Liberty production facility. We estimated the standard errors of bear numbers per cell with bootstrapping. Simulated oil spill footprints for September and October, the times during which we hypothesized effects of an oil-spill would be worst, were estimated using real wind and current data collected between 1980 and 1996. We used ARC/Info software to calculate overlap (numbers of bears oiled) between simulated oil-spill footprints and polar bear grid-cell values. Numbers of bears potentially oiled by a hypothetical 5912 barrel spill (the largest spill thought probable from a pipeline breach) ranged from 0 to 27 polar bears for September open water conditions, and from 0 to 74 polar bears in October mixed ice conditions. Median numbers oiled by the 5912 barrel hypothetical spill from the Liberty simulation in September and October were 1 and 3 bears, equivalent values for the Northstar simulation were 3 and 11 bears. In October, 75% of trajectories from the 5912 barrel simulated spill at Liberty oiled 9 or fewer bears while 75% of the trajectories affected 20 or

  3. Gonadorelin at the outset and/or end of an ovulation synchronization progesterone estradiol benzoate-based protocol in Nellore females

    Directory of Open Access Journals (Sweden)

    Carla Cristian Campos

    2016-02-01

    Full Text Available This study aimed to evaluate the effects of gonadorelin (GnRH, used both at the outset of a timed artificial insemination (TAI protocol to synchronize follicular wave recruitment and at the end to synchronize ovulation, on the conception rate (CR in Nellore cows. The experiment was conducted on two beef cattle farms in the Vale do Araguaia, MT. The body condition score (BCS evaluation and ultrasound examination to determine ovarian status [follicle diameter < 10 mm, ? 10 mm or presence of corpus luteum (CL] were performed at the beginning (Day 0 of the TAI protocol. Multiparous cows (n = 494 were subjected to the following protocol: Day 0 – insertion of intravaginal progesterone device (P4 DIB®, MSD previously used for 8 or 16 days and IM administration of 2.0 mg of estradiol benzoate (EB, Gonadiol®, MSD; Day 8 – P4 device withdrawal, IM injection of 300 IU of equine chorionic gonadotropin (eCG, Folligon®, MSD, 1.0 mg of estradiol cypionate (ECP®, Zoetis and 0.265 mg of Sodium cloprostenol (PGF2?, Ciosin®, MSD; Day 10 – TAI, performed by a single inseminator. Animals were randomly assigned to one of four groups: control (n = 126, GnRH D0 (n = 123, GnRH D10 (n = 123 and GnRH D0 + D10 (n = 122. Animals treated with GnRH received 50 mcg of gonadorelin (GnRH, Cystorelin®, Merial. Pregnancy was diagnosed by ultrasound 39 ± 10 days after TAI. Data were analyzed using the GLIMMIX procedure of SAS program (P < 0.05. The overall CR was 42.71%. Effect of treatment was not detected (P = 0.2482 on CR, which was 36.89% ± 0.19 (47/126 for the control group, 46.08% ± 0.19 (56/123 for GnRH D0, 48.30% ± 0.18 (61/123 for GnRH D10 and 38.48% ± 0.19 (47/122 for GnRH D0 + D10. An effect of farm was detected; the CR was 47.32% ± 0.13 at Farm A and was 38.24% ± 0.13 at Farm B (P = 0.0249. No effects of the interaction between farm and treatment were observed (P = 0.7662, nor of those among ovarian condition and treatment (P = 0.1225 on CR. Cows with

  4. Increasing estradiol benzoate, pretreatment with gonadotropin-releasing hormone, and impediments for successful estradiol-based fixed-time artificial insemination protocols in dairy cattle.

    Science.gov (United States)

    Monteiro, P L J; Borsato, M; Silva, F L M; Prata, A B; Wiltbank, M C; Sartori, R

    2015-06-01

    With the objective to optimize fixed-time artificial insemination (FTAI) protocols based on estradiol benzoate (EB) and progesterone (P4), we performed 2 experiments (Exp.) in dairy cows. In Exp. 1 (n=44), we hypothesized that increased EB (EB3=3 mg vs. EB2=2 mg) on d 0 would improve synchronization of ovarian follicle wave emergence. Likewise, in Exp. 2 (n=82), we hypothesized that a GnRH treatment on d -3 (early in a follicular wave on d 0) versus d -7 (presence of a dominant follicle on d 0) would better synchronize wave emergence. Moreover, results from both experiments were combined to identify reasons for the lack of synchronization. All cows were treated with EB at the time of introduction of a P4 implant (d 0). On d 7, cows were given 25 mg of prostaglandin F2α; on d 8, the implant was removed and cows were given 1mg of estradiol cypionate. All cows received FTAI on d 10. In both experiments, daily ultrasound evaluations were performed and, in Exp. 2, circulating P4 was evaluated during the protocol. Pregnancy per artificial insemination (P/AI) was determined on d 31 and 59 after FTAI. In Exp. 1, EB dose did not change time to wave emergence, but EB3 compared with EB2 decreased the percentage of cows with a corpus luteum on d 7 (19.8 vs. 55.3%) and time to ovulation (10.4 vs. 10.9 d). In Exp. 2, although we detected a tendency for delayed follicle wave emergence after the start of the FTAI protocol in cows ovulating to GnRH given on d -7, there was no difference in percentage of cows with a synchronized wave emergence (~80%). Regardless of treatment, more cows with P4<0.1 ng/mL, compared with P4≥0.1 and <0.22 ng/mL at the time of AI, ovulated to the protocol (81.2 vs. 58.0%) and had increased P/AI (47.4 vs. 21.4%). An analysis of data from both experiments showed that only 73.8% (93/126) of cows had synchronized wave emergence, and only 77.8% (98/126) of cows ovulated at the end of the protocol. Fertility was much greater in cows that had emergence of a

  5. HPLC法测定氨酚麻美糖浆中苯甲酸钠的含量%Determination of Sodium Benzoate in Paracetamol, Pseudoephedrine Hydrochloride and Dextromethorphane Syrup by HPLC

    Institute of Scientific and Technical Information of China (English)

    张瑜; 卢丹; 王冬

    2014-01-01

    目的:建立氨酚麻美糖浆中苯甲酸钠含量测定方法。方法:采用HPLC法测定,色谱柱为Thermo C18(4.6 mm ×100 mm,2.4μm),流动相为0.05 mol· L-1磷酸二氢钾溶液(用磷酸调节pH值至3.5±0.1)-甲醇(38∶62),检测波长为215 nm,进样量2μL。结果:苯甲酸钠在40.14~281.01μg· mL-1浓度范围内线性关系良好,平均回收率为99.0%( RSD=1.5%)。结论:所建方法专属性好,准确,重复性好,可为氨酚麻美糖浆中有效检测防腐剂苯甲酸钠的含量提供参考。%Objective:To establish an HPLC method for determining the content of sodium benzoate in paracetamol , pseudoephedrine hydrochloride and dextromethorphane syrup.Methods:The determination was performed on a column Thermo C 18 (4.6 mm ×100 mm, 2.4 μm) with a mixture of 0.05 mol· L-1 potassium dihydrogenphosphate solution (adjusted pH with phosphoric acid to 3.5 ±0.1) and methanol (38∶62) as mobile phase, the wavelength was 215 nm and the injection volume was 2μL.Results:A good linearity was obtained in range of 40.14-281.01 μg · mL-1 of sodium benzoate and the average recovery was 99.0%( RSD=1.5%) .Conclu-sion:This method is specific and accurate with good repeatability.It would take a good role in the control of sodium benzoate in their mixture syrup.

  6. Content Determination of Sodium Benzoate in Acetaminophen Oral Solution by HPLC%高效液相色谱法测定对乙酰氨基酚口服溶液中苯甲酸钠含量

    Institute of Scientific and Technical Information of China (English)

    李玲; 陈乃江; 姜燕

    2016-01-01

    Objective To determine the content of sodium benzoate in acetaminophen oral solution by HPLC. Methods The Phenomenex Gemini C18 column(250 mmí4. 6 mm, 5 μm) was used, and the mobile phase was acetonitrile -0. 05 mol/L ammonium acetate(15:85). The flow rate was 1. 0 mL/min and the detection wavelength was set at 230 nm. The column temperature was 30 ℃ and the injection volume was 20 μL. Results The linear range of sodium benzoate was 10. 04-100. 4 μg/mL ( r=0. 999 9 ) , the average recovery was 99. 83% and RSD was 0. 99%( n=9 ) , the limit of detection was 1. 3 ng. Conclusion The method is applicable to the quality control of sodium benzoate in acetaminophen oral solution, which can provide reference for the standard improvement.%目的:建立测定对乙酰氨基酚口服溶液中防腐剂苯甲酸钠含量的高效液相色谱法。方法色谱柱为Phenomenex Gemini C18柱(250 mm伊4.6 mm,5μm),流动相为乙腈-0.05 mol/L乙酸铵(15:85),流速为1.0 mL/min,检测波长为230 nm,柱温为30益,进样量为20μL。结果苯甲酸钠质量浓度在10.04~100.4μg/mL范围内与峰面积线性关系良好( r=0.9999),平均回收率为99.83%, RSD为0.99%( n=9),苯甲酸钠检测限为1.3 ng。结论该方法适用于对乙酰氨基酚口服溶液中苯甲酸钠的质量控制,可为该品种标准的提升提供参考。

  7. Foothills model forest grizzly bear study : project update

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-01-01

    This report updates a five year study launched in 1999 to ensure the continued healthy existence of grizzly bears in west-central Alberta by integrating their needs into land management decisions. The objective was to gather better information and to develop computer-based maps and models regarding grizzly bear migration, habitat use and response to human activities. The study area covers 9,700 square km in west-central Alberta where 66 to 147 grizzly bears exist. During the first 3 field seasons, researchers captured and radio collared 60 bears. Researchers at the University of Calgary used remote sensing tools and satellite images to develop grizzly bear habitat maps. Collaborators at the University of Washington used trained dogs to find bear scat which was analyzed for DNA, stress levels and reproductive hormones. Resource Selection Function models are being developed by researchers at the University of Alberta to identify bear locations and to see how habitat is influenced by vegetation cover and oil, gas, forestry and mining activities. The health of the bears is being studied by researchers at the University of Saskatchewan and the Canadian Cooperative Wildlife Health Centre. The study has already advanced the scientific knowledge of grizzly bear behaviour. Preliminary results indicate that grizzlies continue to find mates, reproduce and gain weight and establish dens. These are all good indicators of a healthy population. Most bear deaths have been related to poaching. The study will continue for another two years. 1 fig.

  8. Fatigue Life Analysis of Rolling Bearings Based on Quasistatic Modeling

    Directory of Open Access Journals (Sweden)

    Wei Guo

    2015-01-01

    Full Text Available Rolling bearings are widely used in aeroengine, machine tool spindles, locomotive wheelset, and so forth. Rolling bearings are usually the weakest components that influence the remaining life of the whole machine. In this paper, a fatigue life prediction method is proposed based on quasistatic modeling of rolling bearings. With consideration of radial centrifugal expansion and thermal deformations on the geometric displacement in the bearings, the Jones’ bearing model is updated, which can predict the contact angle, deformation, and load between rolling elements and bearing raceways more accurately. Based on Hertz contact theory and contact mechanics, the contact stress field between rolling elements and raceways is calculated. A coupling model of fatigue life and damage for rolling bearings is given and verified through accelerated life test. Afterwards, the variation of bearing life is investigated under different working conditions, that is, axial load, radial load, and rotational speed. The results suggested that the working condition had a great influence on fatigue life of bearing parts and the order in which the damage appears on bearing parts.

  9. Lubrication of an 85-mm ball bearing with RP-1

    Science.gov (United States)

    Addy, Harold E., Jr.; Schuller, Fredrick T.

    1993-01-01

    A parametric experimental investigation of an 85 millimeter bore angular contact ball bearing running in RP-1 fuel was performed at speeds of 10,000 to 24,000 rpm. Thrust loads were varied from 4450 to 17,800 Newtons (1000 to 4000 lbs.). Radial loads were varied from 1335 to 13,350 Newtons (300 to 3000 lbs.). RP-1 lubrication for the bearing was provided through a stationary jet ring located adjacent to the test bearing outer ring. Increases in both the thrust and radial loads resulted in increased bearing temperature, while increases in shaft speed resulted in much more dramatic increases in bearing temperature. These trends are typical for ball bearings operating under these types of conditions. Results are given for outer ring temperatures of the test bearing at the various test conditions employed. In addition, the heat energy removed from the bearing by the RP-1 was determined by measuring the increase in temperature as the RP-1 passed through the bearing. Results showed that the amount of heat energy removed by the RP-1 increased with both shaft speed and RP-1 flow rate to the bearing.

  10. Optimization analysis on assembly interference of cylindrical roller bearings

    Directory of Open Access Journals (Sweden)

    Zhen-huan Ye

    2015-07-01

    Full Text Available Distribution of loads and contact stress has a great influence on fatigue life of bearings. In view of the fact that the nonload area is ubiquitous in cylindrical roller bearings, there is a method for prolonging the fatigue life design by adjusting the working clearance of cylindrical roller bearings. In this article, optimization model of fatigue life of cylindrical roller bearings is developed with a quasi-dynamic method and calculated method of bearing life based on micro-area contact, considering the effect of assembly interference, temperature rise, and high-speed centrifugation. Aiming to the different geometry parameters and operating parameters of bearings, the effects of assembly interference on bearing fatigue life are discussed. The results show that the optimum fatigue life of roller bearings is achieved at negative working clearance with the loads distributed evenly within half ring. The optimum working clearance of roller bearings is not influenced by radial load. But with the increase in pitch diameter or decrease in rolling elements, the optimum assembly interference increases, and accelerating revolution of roller bearings will increase the optimum assembly interference as well.

  11. Socioeconomic Factors Affecting Local Support for Black Bear Recovery Strategies

    Science.gov (United States)

    Morzillo, Anita T.; Mertig, Angela G.; Hollister, Jeffrey W.; Garner, Nathan; Liu, Jianguo

    2010-06-01

    There is global interest in recovering locally extirpated carnivore species. Successful efforts to recover Louisiana black bear in Louisiana have prompted interest in recovery throughout the species’ historical range. We evaluated support for three potential black bear recovery strategies prior to public release of a black bear conservation and management plan for eastern Texas, United States. Data were collected from 1,006 residents living in proximity to potential recovery locations, particularly Big Thicket National Preserve. In addition to traditional logistic regression analysis, we used conditional probability analysis to statistically and visually evaluate probabilities of public support for potential black bear recovery strategies based on socioeconomic characteristics. Allowing black bears to repopulate the region on their own (i.e., without active reintroduction) was the recovery strategy with the greatest probability of acceptance. Recovery strategy acceptance was influenced by many socioeconomic factors. Older and long-time local residents were most likely to want to exclude black bears from the area. Concern about the problems that black bears may cause was the only variable significantly related to support or non-support across all strategies. Lack of personal knowledge about black bears was the most frequent reason for uncertainty about preferred strategy. In order to reduce local uncertainty about possible recovery strategies, we suggest that wildlife managers focus outreach efforts on providing local residents with general information about black bears, as well as information pertinent to minimizing the potential for human-black bear conflict.

  12. Experimental study on bearing preload optimum of machine tool spindle

    Science.gov (United States)

    Xu, Tao; Xu, Guanghua; Zhang, Qin; Hua, Cheng; Zhang, Hu; Jiang, Kuosheng

    2012-05-01

    An experimental study is conducted to investigate the possibility and the effect of temperature rise and vibration level of bearing by adjusting axial preloads and radial loads in spindle bearing test rig. The shaft of the test rig is driven by a motorized high speed spindle at the range of 0~20000 rpm. The axial preloads and radial loads on bearings are controlled by using hydraulic pressure which can be adjusted automatically. Temperature rise and radial vibration of test bearings are measured by thermocouples and Polytec portable laser vibrometer PDV100. Experiment shows that the temperature rise of bearings is nonlinear varying with the increase of radial loads, but temperature rise almost increases linearly with the increase of axial preload and rotating speed. In this paper, an alternate axial preload is used for bearings. When the rotating speed passes through the critical speed of the shaft, axial preload of bearings will have a remarkable effect. The low preload could reduce bearing vibration and temperature rise for bearings as well. At the others speed, the high preload could improve the vibration performance of high speed spindle and the bearing temperature was lower than that of the constant pressure preload spindle.

  13. Food availability and foraging near human developments by black bears

    Science.gov (United States)

    Merkle, Jerod A.; Robinson, Hugh S.; Krausman, Paul R.; Alaback, Paul B.

    2013-01-01

    Understanding the relationship between foraging ecology and the presence of human-dominated landscapes is important, particularly for American black bears (Ursus americanus), which sometimes move between wildlands and urban areas to forage. The food-related factors influencing this movement have not been explored, but can be important for understanding the benefits and costs to black bear foraging behavior and the fundamental origins of bear conflicts. We tested whether the scarcity of wildland foods or the availability of urban foods can explain when black bears forage near houses, examined the extent to which male bears use urban areas in comparison to females, and identified the most important food items influencing bear movement into urban areas. We monitored 16 collared black bears in and around Missoula, Montana, during 2009 and 2010, while quantifying the rate of change in green vegetation and the availability of 5 native berry-producing species outside the urban area, the rate of change in green vegetation, and the availability of apples and garbage inside the urban area. We used parametric time-to-event models in which an event was a bear location collected within 100 m of a house. We also visited feeding sites located near houses and quantified food items bears had eaten. The probability of a bear being located near a house was 1.6 times higher for males, and increased during apple season and the urban green-up. Fruit trees accounted for most of the forage items at urban feeding sites (49%), whereas wildland foods composed <10%. Black bears foraged on human foods near houses even when wildland foods were available, suggesting that the absence of wildland foods may not influence the probability of bears foraging near houses. Additionally, other attractants, in this case fruit trees, appear to be more important than the availability of garbage in influencing when bears forage near houses.

  14. Evaluation of a hybrid hydrostatic bearing for cryogenic turbopump application

    Science.gov (United States)

    Spica, P. W.; Hannum, N. P.; Meyer, S. D.

    1986-01-01

    A hybrid hydrostatic bearing was designed to operate in liquid hydrogen at speeds to 80,000 rpm and radial loads to 440 n (100 lbf). The bearing assembly consisted of a pair of 20-mm angular-contact ball bearings encased in a journal, which was in turn supported by a fluid film of liquid hydrogen. The size and operating conditions of the bearing were selected to be compatible with the operating requirements of an advanced technology turbopump. Several test parameters were varied to characterize the bearing's steady-state operation. The rotation of the tester shaft was varied between 0 and 80,000 rpm. Bearing inlet fluid pressure was varied between 2.07 and 4.48 MPa (300 and 650 psia), while the fluid sump pressure was independently varied between 0.34 and 2.07 MPa (50 and 300 psia). The maximum radial load applied to the bearing was 440 N (110 lbf). Measured hybrid-hydrostatic-bearing stiffness was 1.5 times greater than predicted, while the fluid flow rate through the bearing was 35 to 65 percent less than predicted. Under two-phase fluid conditions, the stiffness was even greater and the flow rate was less. The optimal pressure ratio for the bearing should be between 0.2 and 0.55 depending on the balance desired between bearing efficiency and stiffness. Startup and shutdown cyclic tests were conducted to demonstrate the ability of the hybrid-hydrostatic-bearing assembly to survive at least a 300-firing-duty cycle. For a typical cycle, the shaft was accelerated to 50,000 rpm in 1.8 sec. The bearing operated for 337 start-stop cycles without failure.

  15. BEARS: Radioactive ion beams at LBNL

    Energy Technology Data Exchange (ETDEWEB)

    Powell, J.; Guo, F.Q. [Lawrence Berkeley National Lab., CA (United States); Haustein, P.E. [Brookhaven National Lab., Upton, NY (United States). Chemistry Dept.] [and others

    1998-07-01

    BEARS (Berkeley Experiments with Accelerated Radioactive Species) is an initiative to develop a radioactive ion-beam capability at Lawrence Berkeley National Laboratory. The aim is to produce isotopes at an existing medical cyclotron and to accelerate them at the 88 inch Cyclotron. To overcome the 300-meter physical separation of these two accelerators, a carrier-gas transport system will be used. At the terminus of the capillary, the carrier gas will be separated and the isotopes will be injected into the 88 inch Cyclotron`s Electron Cyclotron Resonance (ECR) ion source. The first radioactive beams to be developed will include 20-min {sup 11}C and 70-sec {sup 14}O, produced by (p,n) and (p,{alpha}) reactions on low-Z targets. A test program is currently being conducted at the 88 inch Cyclotron to develop the parts of the BEARS system. Preliminary results of these tests lead to projections of initial {sup 11}C beams of up to 2.5 {times} 10{sup 7} ions/sec and {sup 14}O beams of 3 {times} 10{sup 5} ions/sec.

  16. Incipient failure detection (IFD) of SSME ball bearings

    Science.gov (United States)

    1982-01-01

    Because of the immense noise background during the operation of a large engine such as the SSME, the relatively low level unique ball bearing signatures were often buried by the overall machine signal. As a result, the most commonly used bearing failure detection technique, pattern recognition using power spectral density (PSD) constructed from the extracted bearing signals, is rendered useless. Data enhancement techniques were carried out by using a HP5451C Fourier Analyzer. The signal was preprocessed by a Digital Audio Crop. DAC-1024I noise cancelling filter in order to estimate the desired signal corrupted by the backgound noise. Reference levels of good bearings were established. Any deviation of bearing signals from these reference levels indicate the incipient bearing failures.

  17. A Review on Prognosis of Rolling Element Bearings

    Directory of Open Access Journals (Sweden)

    N.S. Jammu

    2011-10-01

    Full Text Available Bearings are amongst the frequently encountered components to be found in rotating machinery. Though inexpensive, their failure can interrupt the production in a plant causing unscheduled downtime and production losses. So the bearing prognosis plays a significant role in reducing plant down time and enhanced operation safety, by estimating the Remaining Useful Life (RUL of damaged bearing. Admitting the importance of bearing prognosis, this literature reviewattempts to summarize various techniques, methods and models used in the prognosis of bearing till date. The definition of bearing prognosis is discussed in the beginning, followed by classification ofvarious prognostic methods, review of methods used by various investigators in this research domain and concluding the topic with the summary of future research directions.

  18. Wear fault diagnosis of an emulsion pump crank bearing

    Institute of Scientific and Technical Information of China (English)

    HAN Xiao-ming; DU Chang-long; ZHANG Yong-zhong; TIE Zhan-xu

    2008-01-01

    The total load on a crank bearing was calculated by performing a load analysis of the crank connecting rod mechanism.The Reynolds equation for hydrodynamic lubrication of the crank bearing was established at the Reynolds boundary condition and was then solved using the Holland method. From this the regular track of the bearing axis was obtained. As the crank bearing gradually wears the eccentricity ratio corresponding to the minimum oil film thickness increases gradually. The oil-bound film eventually breaks down, which allows friction and collision between the metal surfaces of the crank pin and the bearing. The rigid impact leads to excitation of high frequency vibrations at the natural frequencies of the connecting rod. The experiments show that the wear condition of the crank bearing can be identified correctly through the vibration signature at the natural frequencies of the connecting rod. The degree of wear can be predicted accurately through the energy content of the high frequency bands.

  19. Modeling of dynamically loaded hydrodynamic bearings at low Sommerfeld numbers

    DEFF Research Database (Denmark)

    Thomsen, Kim

    by environment and other wind turbine components. In this work a numerical multiphysics bearing model is developed in order to allow for accurate performance prediction of hydrodynamic bearings subjected to the challenging conditions that exist in modern wind turbines. This requires the coupling of several...... different theoretical fields: • fluid film forces • heat transfer • thermoviscous effects • dynamic response • deformation of structure and components • angular misalignment • wear The multiphysics bearing model is applied for various bearing types in order to study the bearings, their hydrodynamic...... performance and related phenomena: • a new wear model is proposed which can, with only moderate efforts, be implemented into existing EHD models. • it is discovered that radial tilting pad bearings can exhibit discontinuity effects when subjected high dynamic loads. • the influence of compliant liners...

  20. On the future of controllable fluid film bearings

    DEFF Research Database (Denmark)

    Santos, Ilmar

    2011-01-01

    This work gives an overview of the theoretical and experimental achievements of mechatronics applied to fluid film bearings. Compressible and uncompressible fluids are addressed. Rigid and elastic (deformable) bearing profiles are investigated. Hydraulic, pneumatic, magnetic and piezoelectric...... controllable fluid film bearings is to improve the overall machine performance by: controlling the lateral vibration of rigid and flexible rotating shafts; modifying bearing dynamic characteristics, such as stiffness and damping properties; increasing the rotational speed ranges by enhancing damping...... and eliminating instability problems, for example, by compensating cross-coupling destabilizing effects; reducing start-up torque and energy dissipation in bearings; compensating thermal effects. It is shown that such controllable fluid film bearings can act as “smart” machine components and be applied...

  1. Enhancing stability of industrial turbines using adjustable partial arc bearings

    Science.gov (United States)

    Chasalevris, Athanasios; Dohnal, Fadi

    2016-09-01

    The paper presents the principal of operation, the simulation and the characteristics of two partial-arc journal bearings of variable geometry and adjustable/controllable stiffness and damping properties. The proposed journals are supposed to consist of a scheme that enables the periodical variation of bearing properties. Recent achievements of suppressing rotor vibrations using plain circular journal bearings of variable geometry motivate the further extension of the principle to bearings of applicable geometry for industrial turbines. The paper describes the application of a partial-arc journal bearing to enhance stability of high speed industrial turbines. The proposed partial-arc bearings with adjustable/controllable properties enhance stability and they introduce stable margins in speeds much higher than the 1st critical.

  2. Studies on Excess Volume, Viscosity, and Speed of Sound of Binary Mixtures of Methyl Benzoate in Ethers at T=(303.15,308.15, and 313.15 K

    Directory of Open Access Journals (Sweden)

    M. V. Rathnam

    2013-01-01

    Full Text Available Densities, viscosities, and speed of sound have been determined at T = (303.15, 308.15, and 313.15 K for the binary mixtures of methyl benzoate with tetrahydrofuran, 1,4-dioxane, anisole, and butyl vinyl ether over the entire range of composition. Using these measured values, excess volume VE, deviation in viscosities Δη, excess Gibb’s free energy of activation for viscous flow ΔG*E, and deviation in isentropic compressibility Δks have been calculated. These calculated binary data have been fitted to Redlich-Kister equation to determine the appropriate coefficients. The values of excess volume VE and deviation in viscosities Δη are negative over the entire range of composition for all the binary systems at the studied temperatures. The behavior of these parameters with composition of the mixture has been discussed in terms of molecular interactions between the components of liquids.

  3. Crystal structure of ethyl 4-[(E)-(4-hy­droxy-3-meth­oxy­benzyl­idene)amino]­benzoate: a p-hy­droxy Schiff base

    Science.gov (United States)

    Ling, Jing; Kavuru, Padmini; Wojtas, Lukasz; Chadwick, Keith

    2016-01-01

    The title p-hy­droxy Schiff base, C17H17NO4, was synthesized via the condensation reaction of benzocaine with vanillin. The benzyl­idine and benzoate rings are inclined to one another by 24.58 (8)°, and the conformation about the C=N bond is E. In the crystal, mol­ecules are linked by O—H⋯N hydrogen bonds, forming zigzag chains propagating along [010]. Adjacent chains are linked by C—H⋯π and weak offset π–π inter­actions [inter­centroid distance = 3.819 (1) Å], forming sheets parallel to (10-2). PMID:27555938

  4. 苯甲酸铜三元配合物的谱学研究与成键特征%Study on the synthesis and spectrum of copper(Ⅱ) benzoate ternary complex

    Institute of Scientific and Technical Information of China (English)

    田俐; 陈琳

    2001-01-01

    对苯甲酸铜三元配合物单晶[Cu(ba)2(phen)(H2O)]2(ba表示苯甲酸根阴离子;phen 表示1,10-邻菲咯啉)进行了红外光谱和电子吸收光谱研究,探讨了配位中心铜(Ⅱ)离子的成键特征.%In this paper, the copper(Ⅱ) benzoate ternary complex [Cu(ba)2(phen)(H2O)]2(where ba=benzoic acid and phen=1,10-phenanthroline has been synthesized. It was studied by IR and UV-VIS spectrum which indicates that Cu(Ⅱ)ion is five coordinated in the complex.

  5. HPLC法测定并比较药用级与非药用级苯甲酸钠的含量%Determination and Comparison of the Content of Sodium Benzoate in Medicinal and Non-medicinal Grade by HPLC

    Institute of Scientific and Technical Information of China (English)

    粟贵; 刘雁鸣; 龙海燕; 李颖; 廖彬

    2016-01-01

    OBJECTIVE:To establish a method to determine and compare the contents of sodium benzoate in medicinal(phar-maceutical excipients and active pharmaceutical ingredients) and non-medicinal (chemical reagents and food additives) grade. METHODS:HPLC was conducted for content determination,SPSS 18.0 software was adopted to compare the results. The column was Purospher STAR LP RP-18 endcapped with mobile phase of acetotrile-0.02% formic acid(adjusted pH to 4.0 with aqua ammo-nia)(30∶70,V/V)at a flow rate was 1.0 ml/min,the detection wavelength was 230 nm,column temperature was 35 ℃,and vol-ume injection was 20 μl. RESULTS:The linear range of sodium benzoate was 10.5-525.3 μg/ml(r=0.999 9);RSDs of precision, stability,reproducibility and durability tests were lower than 0.5%;recovery was 99.38%-101.26%(RSD=0.56%,n=9). The av-erage contents of sodium benzoate in medicinal and non-medicinal grade were between 99.400%-99.875%,but the average content of non-medicinal grade is lower than the medical grade. CONCLUSIONS:The method is accurate and simple with high specificity and good reproducibility,and can be used to determine and compare the content of sodium benzoate in medicinal and non-medici-nal grade.%目的:建立测定并比较药用级(药用辅料和原料药)与非药用级(化学试剂和食品添加剂)苯甲酸钠含量的方法。方法:采用高效液相色谱法测定含量,并采用SPSS 18.0软件对含量测定结果进行统计和比较。色谱柱为Purospher STAR LP RP-18 endcapped,流动相为乙腈-0.02%甲酸(用氨水调pH至4.0)(30∶70,V/V),流速为1.0 ml/min,检测波长为230 nm,柱温为35℃,进样量为20μl。结果:苯甲酸钠检测质量浓度线性范围为10.5~525.3μg/ml(r=0.9999);精密度、稳定性、重复性、耐用性试验的RSD<0.5%;加样回收率为99.38%~101.26%(RSD=0.56%,n=9)。药用级与非药用级样品含量均值在99.400%~99.875%之

  6. Suppression of Base Excitation of Rotors on Magnetic Bearings

    OpenAIRE

    2007-01-01

    This paper deals with rotor systems that suffer harmonic base excitation when supported on magnetic bearings. Magnetic bearings using conventional control techniques perform poorly in such situations mainly due to their highly nonlinear characteristics. The compensation method presented here is a novel optimal control procedure with a combination of conventional, proportional, and differential feedback control. A four-degree-of-freedom model is used for the rotor system, and the bearings a...

  7. Fatigue Crack Initiation and Propagation of Aluminum Alloy Bearings

    Institute of Scientific and Technical Information of China (English)

    CHENG Xian-Hua; MA Yan-Yan

    2004-01-01

    Observation of fatigue crack initiation and propagation during fatigue test in ALSn20Cu bearing has been presented. Journal center orbit, oil film pressure and stress distribution in alloy layer have been calculated and are taken as the basis for theoretically simulating the bearing fatigue process. It is found that the calculated results are in good accordance with the experimental results, which provides a feasible way for investigation of fatigue crack propagation process in the bearing.

  8. INVESTIGATION OF TRIBOLOGICAL PROPERTIES CuSn10 BEARING MATERIAL

    OpenAIRE

    2005-01-01

    Bronzes which copper based alloys is widely used because of properties physical, thermal and tribological as journal bearing material. This material that has tribological performance good conclusions gives at journal bearings. In this study, CuSn10 bronze that were manufactured journal bearings friction and wear properties has been examined and compared. SAE 1050 steel shaft has been used as counter abrader. Experiments have been carried out 10 N and 20 N loads, 750 and 1500 rpm, dry and lubr...

  9. Coefficients of Productivity for Yellowstone's Grizzly Bear Habitat

    Science.gov (United States)

    Mattson, David John; Barber, Kim; Maw, Ralene; Renkin, Roy

    2004-01-01

    This report describes methods for calculating coefficients used to depict habitat productivity for grizzly bears in the Yellowstone ecosystem. Calculations based on these coefficients are used in the Yellowstone Grizzly Bear Cumulative Effects Model to map the distribution of habitat productivity and account for the impacts of human facilities. The coefficients of habitat productivity incorporate detailed information that was collected over a 20-year period (1977-96) on the foraging behavior of Yellowstone's bears and include records of what bears were feeding on, when and where they fed, the extent of that feeding activity, and relative measures of the quantity consumed. The coefficients also incorporate information, collected primarily from 1986 to 1992, on the nutrient content of foods that were consumed, their digestibility, characteristic bite sizes, and the energy required to extract and handle each food. Coefficients were calculated for different time periods and different habitat types, specific to different parts of the Yellowstone ecosystem. Stratifications included four seasons of bear activity (spring, estrus, early hyperphagia, late hyperphagia), years when ungulate carrion and whitebark pine seed crops were abundant versus not, areas adjacent to (bear activity in each region, habitat type, and time period were incorporated into calculations, controlling for the effects of proximity to human facilities. The coefficients described in this report and associated estimates of grizzly bear habitat productivity are unique among many efforts to model the conditions of bear habitat because calculations include information on energetics derived from the observed behavior of radio-marked bears.

  10. Grizzly bear density in Glacier National Park, Montana

    Science.gov (United States)

    Kendall, K.C.; Stetz, J.B.; Roon, David A.; Waits, L.P.; Boulanger, J.B.; Paetkau, David

    2008-01-01

    We present the first rigorous estimate of grizzly bear (Ursus arctos) population density and distribution in and around Glacier National Park (GNP), Montana, USA. We used genetic analysis to identify individual bears from hair samples collected via 2 concurrent sampling methods: 1) systematically distributed, baited, barbed-wire hair traps and 2) unbaited bear rub trees found along trails. We used Huggins closed mixture models in Program MARK to estimate total population size and developed a method to account for heterogeneity caused by unequal access to rub trees. We corrected our estimate for lack of geographic closure using a new method that utilizes information from radiocollared bears and the distribution of bears captured with DNA sampling. Adjusted for closure, the average number of grizzly bears in our study area was 240.7 (95% CI = 202–303) in 1998 and 240.6 (95% CI = 205–304) in 2000. Average grizzly bear density was 30 bears/1,000 km2, with 2.4 times more bears detected per hair trap inside than outside GNP. We provide baseline information important for managing one of the few remaining populations of grizzlies in the contiguous United States.

  11. Grizzly bears and mining in the Cheviot region

    Energy Technology Data Exchange (ETDEWEB)

    Symbaluk, M.; Archibald, T. [Foothills Research Inst., Hinton, AB (Canada)

    2008-07-01

    This presentation described a grizzly bear research program conducted by the Foothill Research Institute at the Cheviot mine. The research program uses a satellite land classification protocol and remote sensing tools to map and identify the grizzly bear habitat. Modelling is also conducted to predict bear probabilities. Global information systems (GIS) are used to evaluate bear responses to human activities. Grizzly bear health and wellness is also assessed as part of the programs. Land maps are combined with global positioning systems (GPS) and resource selection function (RSF) models in order to map grizzly bear distribution. Data obtained from the program is used to inform decision-making and support policy development. Previous studies predicted that the grizzly bear population would disappear from the Cheviot mine area after 20 years of its being in operation. The research program provided real data to test predictions made during previous environmental assessments. Grizzly bear populations have actually increased in the mining area. It was concluded that the bears have moved more freely through industrial landscapes than previously predicted. tabs., figs.

  12. Gene transcription in polar bears (Ursus maritimus) from disparate populations

    Science.gov (United States)

    Bowen, Lizabeth; Miles, A. Keith; Waters, Shannon C.; Meyerson, Randi; Rode, Karyn D.; Atwood, Todd C.

    2015-01-01

    Polar bears in the Beaufort (SB) and Chukchi (CS) Seas experience different environments due primarily to a longer history of sea ice loss in the Beaufort Sea. Ecological differences have been identified as a possible reason for the generally poorer body condition and reproduction of Beaufort polar bears compared to those from the Chukchi, but the influence of exposure to other stressors remains unknown. We use molecular technology, quantitative PCR, to identify gene transcription differences among polar bears from the Beaufort and Chukchi Seas as well as captive healthy polar bears. We identified significant transcriptional differences among a priori groups (i.e., captive bears, SB 2012, SB 2013, CS 2013) for ten of the 14 genes of interest (i.e., CaM, HSP70, CCR3, TGFβ, COX2, THRα, T-bet, Gata3, CD69, and IL17); transcription levels of DRβ, IL1β, AHR, and Mx1 did not differ among groups. Multivariate analysis also demonstrated separation among the groups of polar bears. Specifically, we detected transcript profiles consistent with immune function impairment in polar bears from the Beaufort Sea, when compared with Chukchi and captive polar bears. Although there is no strong indication of differential exposure to contaminants or pathogens between CS and SB bears, there are clearly differences in important transcriptional responses between populations. Further investigation is warranted to refine interpretation of potential effects of described stress-related conditions for the SB population.

  13. Novel High Temperature Magnetic Bearings for Space Vehicle Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Previous high temperature magnetic bearings employed only electromagnets. The work proposed in this SBIR program seeks to utilize High Temperature Permanent Magnets...

  14. Gearbox Reliability Collaborative Gearbox 3 Planet Bearing Calibration

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Jonathan [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-03-24

    The Gearbox Reliability Collaborative gearbox was redesigned to improve its load-sharing characteristics and predicted fatigue life. The most important aspect of the redesign was to replace the cylindrical roller bearings with preloaded tapered roller bearings in the planetary section. Similar to previous work, the strain gages installed on the planet tapered roller bearings were calibrated in a load frame. This report describes the calibration tests and provides the factors necessary to convert the measured units from dynamometer testing to bearing loads, suitable for comparison to engineering models.

  15. Roller Bearing Monitoring by New Subspace-Based Damage Indicator

    Directory of Open Access Journals (Sweden)

    G. Gautier

    2015-01-01

    Full Text Available A frequency-band subspace-based damage identification method for fault diagnosis in roller bearings is presented. Subspace-based damage indicators are obtained by filtering the vibration data in the frequency range where damage is likely to occur, that is, around the bearing characteristic frequencies. The proposed method is validated by considering simulated data of a damaged bearing. Also, an experimental case is considered which focuses on collecting the vibration data issued from a run-to-failure test. It is shown that the proposed method can detect bearing defects and, as such, it appears to be an efficient tool for diagnosis purpose.

  16. Research on Bored Bearing Characteristics in Xi’an

    Directory of Open Access Journals (Sweden)

    Zhang Lipeng

    2015-01-01

    Full Text Available To analyze the influence of different soil properties on pile foundation load-bearing characteristics, taking a section of railway in Xi’an and a bridge of Xi’an as test area, and by field static load test to study load transfer characteristics after the test piles under axial pressure, including the distribution of axial force, pile lateral friction, tip resistance traits, ultimate bearing capacity determine, and compare with the theory bearing capacity. Experimental results show that, adjacent soil properties change large, axial force and lateral friction mutation at the junction of corresponding soil layer. Silty clay in different parts is below ground, and its lateral friction plays much difference. Pile lateral friction plays an important role in bearing capacity, but the role of round gravel soil end bearing capacity to pile bearing capacity can’t be ignored. Tests calculate pile bearing capacity significantly larger than standardized formula calculation bearing capacity, which are respectively 55.35% and 119.1%. And give the similar project condition the suggested values of pile bearing capacity and soil friction, to provide reference for similar pile foundation design.

  17. Numerical Analysis of Nonlinear Rotor-bearing-seal System

    Institute of Scientific and Technical Information of China (English)

    CHENG Mei; MENG Guang; JING Jian-ping

    2008-01-01

    The system state trajectory, Poincaré maps, largest Lyapunov exponents, frequency spectra and bifurcation diagrams were used to investigate the non-linear dynamic behaviors of a rotor-bearing-seal coupled system and to analyze the influence of the seal and bearing on the nonlinear characteristics of the rotor system. Various nonlinear phenomena in the rotor-bearing-seal system, such as periodic motion, double-periodicmotion, multi-periodic motion and quasi-periodic motion were investigated. The results may contribute to a further understanding of the non-linear dynamics of the rotor-bearing-seal coupled system.

  18. Interaction of Reinforced Elastomeric Bearings in Bridge Construction

    Directory of Open Access Journals (Sweden)

    Nittmannová Ľubica

    2016-03-01

    Full Text Available The aim of this paper is to demonstrate the behavior of reinforced elastomeric bearings under various loads. They are made of special types of bearings. The experimental verification of these special bearings has been tested on various types of loading. The results of the experimental measurements are compared with the results of the numerical modeling and calculations according to the standard assumptions in STN EN 1337-3. In the conclusion, the results are summarized for the selected types of bearings.

  19. Modeling of Tilting-Pad Journal Bearings with Transfer Functions

    Directory of Open Access Journals (Sweden)

    J. A. Vázquez

    2001-01-01

    Full Text Available Tilting-pad journal bearings are widely used to promote stability in modern rotating machinery. However, the dynamics associated with pad motion alters this stabilizing capacity depending on the operating speed of the machine and the bearing geometric parameters, particularly the bearing preload. In modeling the dynamics of the entire rotor-bearing system, the rotor is augmented with a model of the bearings. This model may explicitly include the pad degrees of freedom or may implicitly include them by using dynamic matrix reduction methods. The dynamic reduction models may be represented as a set of polynomials in the eigenvalues of the system used to determine stability. All tilting-pad bearings can then be represented by a fixed size matrix with polynomial elements interacting with the rotor. This paper presents a procedure to calculate the coefficients of polynomials for implicit bearing models. The order of the polynomials changes to reflect the number of pads in the bearings. This results in a very compact and computationally efficient method for fully including the dynamics of tilting-pad bearings or other multiple degrees of freedom components that interact with rotors. The fixed size of the dynamic reduction matrices permits the method to be easily incorporated into rotor dynamic stability codes. A recursive algorithm is developed and presented for calculating the coefficients of the polynomials. The method is applied to stability calculations for a model of a typical industrial compressor.

  20. Novel High Temperature Magnetic Bearings for Space Vehicle Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Previous high temperature magnetic bearings employed electromagnets only. The work proposed in this SBIR program seeks to utilize High Temperature Permanent Magnets...

  1. Bearing problems’ effects on the dynamic performance of pumping stations

    Directory of Open Access Journals (Sweden)

    Mostafa A. Abu-Zeid

    2013-09-01

    Pumping stations use large number of bearings with different types and applications. These bearings have a clear effect on the performance and efficiency of the pumps. Pump bearings in the arid regions are greatly affected by temperature, water quality, lubricants, and maintenance operations. This research focuses on analysis of damaged rolling element bearings of pumping system. The objective of the research is to enhance and control dynamic performance of pumping stations by avoiding damage and failure of bearings. The research proves that damaged bearings generate periodic, non-periodic, and transient forces causing high amplitude of vibration at high frequencies and increasing energy consumption. Bearing faults increase vibration level 85%, where power consumption increases 14% and pump efficiency decreases 18%. It is very important to take care of bearings during installation, alignment, balancing, and maintenance to assure safe and efficient pump operation for long period. As pump efficiency decreases, water power decreases and/or consumed power increases affecting water distribution and management system. Bearing faults break pumping system for long period affecting irrigation system. Optimum operation of pumping stations helps to save and manage water requirement for development and extension projects in arid regions. The measurements are performed on full scale model in the field, which proves reliable results on similar pumping stations.

  2. Acquired umbilical hernias in four captive polar bears (Ursus maritimus).

    Science.gov (United States)

    Velguth, Karen E; Rochat, Mark C; Langan, Jennifer N; Backues, Kay

    2009-12-01

    Umbilical hernias are a common occurrence in domestic animals and humans but have not been well documented in polar bears. Surgical reduction and herniorrhaphies were performed to correct acquired hernias in the region of the umbilicus in four adult captive polar bears (Ursus maritimus) housed in North American zoos. Two of the four bears were clinically unaffected by their hernias prior to surgery. One bear showed signs of severe discomfort following acute enlargement of the hernia. In another bear, re-herniation led to acute abdominal pain due to gastric entrapment and strangulation. The hernias in three bears were surgically repaired by debridement of the hernia ring and direct apposition of the abdominal wall, while the large defect in the most severely affected bear was closed using polypropylene mesh to prevent excessive tension. The cases in this series demonstrate that while small hernias may remain clinically inconsequential for long periods of time, enlargement or recurrence of the defect can lead to incarceration and acute abdominal crisis. Umbilical herniation has not been reported in free-ranging polar bears, and it is suspected that factors such as body condition, limited exercise, or enclosure design potentially contribute to the development of umbilical hernias in captive polar bears.

  3. Lubrication of Space Shuttle Main Engine Turbopump Bearings

    Science.gov (United States)

    Gibson, Howard; Munafo, Paul (Technical Monitor)

    2001-01-01

    The Space Shuttle has three main engines that are used for propulsion into orbit. These engines are fed propellants by four turbopumps on each engine. A main element in the turbopump is the bearings supporting the rotor that spins the turbine blades and the pump impeller. These bearings are required to spin at very high speeds, support radial and thrust loads, and have high wear resistance without the benefit of lubrication. The liquid hydrogen and oxygen propellants flow through the bearings to cool the surfaces. The volatile nature of the propellants excludes any conventional means of lubrication. Lubrication for these bearings is provided by the ball separator inside the bearing. The separator is a composite material that supplies a transfer film of lubrication to the rings and balls. New separator materials and lubrication schemes have been investigated at Marshall Space Flight Center in a bearing test rig with promising results. Hybrid bearings with silicon nitride balls have also been evaluated. The use of hybrid, silicon nitride ball bearings in conjunction -with better separator materials has shown excellent results. The work that Marshall has done is being utilized in turbopumps flying on the space shuttle fleet and will be utilized in future space travel. This result of this work is valuable for all aerospace and commercial applications where high-speed bearings are used.

  4. Analysis of Thermoelastohydrodynamic Performance of Journal Misaligned Engine Main Bearings

    Institute of Scientific and Technical Information of China (English)

    BI Fengrong; SHAO Kang; LIU Changwen; WANG Xia; ZHANG Jian

    2015-01-01

    To understand the engine maln bearings’ working condition is important in order to improve the performance of engine. However, thermal effects and thermal effect deformations of engine maln bearings are rarely considered simultaneously in most studies. A typical finite element model is selected and the effect of thermoelastohydrodynamic(TEHD) reaction on engine maln bearings is investigated. The calculated method of maln bearing’s thermal hydrodynamic reaction and journal misalignment effect is finite difference method, and its deformation reaction is calculated by using finite element method. The oil film pressure is solved numerically with Reynolds boundary conditions when various bearing characteristics are calculated. The whole model considers a temperature-pressure-viscosity relationship for the lubricant, surface roughness effect, and also an angular misalignment between the journal and the bearing. Numerical simulations of operation of a typical I6 diesel engine maln bearing is conducted and importance of several contributing factors in mixed lubrication is discussed. The performance characteristics of journal misaligned maln bearings under elastohydrodynamic(EHD) and TEHD loads of an I6 diesel engine are received, and then the journal center orbit movement, minimum oil film thickness and maximum oil film pressure of maln bearings are estimated over a wide range of engine operation. The model is verified through the comparison with other present models. The TEHD performance of engine maln bearings with various effects under the influences of journal misalignment is revealed, this is helpful to understand EHD and TEHD effect of misaligned engine maln bearings.

  5. INVESTIGATION OF TRIBOLOGICAL PROPERTIES CuSn10 BEARING MATERIAL

    Directory of Open Access Journals (Sweden)

    Bekir Sadık ÜNLÜ

    2005-01-01

    Full Text Available Bronzes which copper based alloys is widely used because of properties physical, thermal and tribological as journal bearing material. This material that has tribological performance good conclusions gives at journal bearings. In this study, CuSn10 bronze that were manufactured journal bearings friction and wear properties has been examined and compared. SAE 1050 steel shaft has been used as counter abrader. Experiments have been carried out 10 N and 20 N loads, 750 and 1500 rpm, dry and lubricated conditions by using radial journal bearing wear test rig. As a results, high friction coefficient and weigh loss have been obtained at dry condition more than lubricated condition.

  6. Large deflection analysis of a tension-foil bearing

    Science.gov (United States)

    Elrod, David A.

    1996-01-01

    The rolling element bearings (REB's) which support many turbomachinery rotors offer high load capacity, low power requirements, and durability. Two disadvantages of REB's are as follows: rolling or sliding contact within the bearing has life-limiting consequences; and REB's provide essentially no damping. The REB's in the Space Shuttle Main Engine (SSME) turbopumps must sustain high static and dynamic loads, at high speeds, with a cryogenic fluid as lubricant and coolant. The pump end ball bearings limit the life of the SSME high pressure oxygen turbopump (HPOTP). Compliant foil bearing (CFB) manufacturers have proposed replacing turbopump REB's with CFB's. CFB's work well in aircraft air cycle machines, auxiliary power units, and refrigeration compressors. In a CFB, the rotor only contacts the foil support structure during start up and shut down. CFB damping is higher than REB damping. However, the load capacity of the CFB is low, compared to a REB. Furthermore, little stiffness and damping data exist for the CFB. A rotordynamic analysis for turbomachinery critical speeds and stability requires the input of bearing stiffness and damping coefficients. The two basic types of CFB are the tension-dominated bearing and the bending-dominated bearing. Many investigators have analyzed and measured characteristics of tension-dominated foil bearings, which are applied principally in magnetic tape recording. The bending-dominated CFB is used more in rotating machinery. Recently, a new tension-foil bearing configuration has been proposed for turbomachinery applications.

  7. DC Control Effort Minimized for Magnetic-Bearing-Supported Shaft

    Science.gov (United States)

    Brown, Gerald V.

    2001-01-01

    A magnetic-bearing-supported shaft may have a number of concentricity and alignment problems. One of these involves the relationship of the position sensors, the centerline of the backup bearings, and the magnetic center of the magnetic bearings. For magnetic bearings with permanent magnet biasing, the average control current for a given control axis that is not bearing the shaft weight will be minimized if the shaft is centered, on average over a revolution, at the magnetic center of the bearings. That position may not yield zero sensor output or center the shaft in the backup bearing clearance. The desired shaft position that gives zero average current can be achieved if a simple additional term is added to the control law. Suppose that the instantaneous control currents from each bearing are available from measurements and can be input into the control computer. If each control current is integrated with a very small rate of accumulation and the result is added to the control output, the shaft will gradually move to a position where the control current averages to zero over many revolutions. This will occur regardless of any offsets of the position sensor inputs. At that position, the average control effort is minimized in comparison to other possible locations of the shaft. Nonlinearities of the magnetic bearing are minimized at that location as well.

  8. Platelet function in brown bear (Ursus arctos compared to man

    Directory of Open Access Journals (Sweden)

    Särndahl Eva

    2010-06-01

    Full Text Available Abstract Background Information on hemostasis and platelet function in brown bear (Ursus arctos is of importance for understanding the physiological, protective changes during hibernation. Objective The study objective was to document platelet activity values in brown bears shortly after leaving the den and compare them to platelet function in healthy humans. Methods Blood was drawn from immobilized wild brown bears 7-10 days after leaving the den in mid April. Blood samples from healthy human adults before and after clopidogrel and acetylsalicylic acid administration served as control. We analyzed blood samples by standard blood testing and platelet aggregation was quantified after stimulation with various agonists using multiple electrode aggregometry within 3 hours of sampling. Results Blood samples were collected from 6 bears (3 females between 1 and 16 years old and from 10 healthy humans. Results of adenosine diphosphate, aspirin, and thrombin receptor activating peptide tests in bears were all half or less of those in humans. Platelet and white blood cell counts did not differ between species but brown bears had more and smaller red blood cells compared with humans. Conclusion Using three different tests, we conclude that platelet function is lower in brown bears compared to humans. Our findings represent the first descriptive study on platelet function in brown bears and may contribute to explain how bears can endure denning without obvious thrombus building. However, the possibility that our findings reflect test-dependent and not true biological variations in platelet reactivity needs further studies.

  9. Magnetic remanence of hematite-bearing murals

    Science.gov (United States)

    Lanza, R.; Zanella, E.; Saudino, S.

    2009-12-01

    We report on a series of experiments designed to test the ability of hematite-bearing colors to record the direction of the ambient magnetic field. Plasterboards accurately oriented with respect to the Earth's magnetic field were painted with red tempera colors prepared with hematite pigments. Magnetic measurements indicate that the color film retains a remanent magnetization and acquires a well developed magnetic fabric. The remanence direction is close to, yet slightly deviated from the Earth's magnetic field. The deviation is interpreted to result from preferential alignment of the pigment grains parallel to the plasterboard surface and depends on both its orientation with respect to magnetic north and the degree of magnetic anisotropy of the color film, which in turn varies according to the pigment used. Investigation of the magnetic remanence of murals may complement archaeomagnetic information derived from traditional materials such as baked and fired structures.

  10. Passive magnetic bearing for a horizontal shaft

    Energy Technology Data Exchange (ETDEWEB)

    Post, Richard F.

    2003-12-02

    A passive magnetic bearing is composed of a levitation element and a restorative element. The levitation element is composed of a pair of stationary arcuate ferromagnetic segments located within an annular radial-field magnet array. The magnet array is attached to the inner circumference of a hollow shaft end. An attractive force between the arcuate segments and the magnet array acts vertically to levitate the shaft, and also in a horizontal transverse direction to center the shaft. The restorative element is comprised of an annular Halbach array of magnets and a stationary annular circuit array located within the Halbach array. The Halbach array is attached to the inner circumference of the hollow shaft end. A repulsive force between the Halbach array and the circuit array increases inversely to the radial space between them, and thus acts to restore the shaft to its equilibrium axis of rotation when it is displaced therefrom.

  11. Cationic ruthenium alkylidene catalysts bearing phosphine ligands.

    Science.gov (United States)

    Endo, Koji; Grubbs, Robert H

    2016-02-28

    The discovery of highly active catalysts and the success of ionic liquid immobilized systems have accelerated attention to a new class of cationic metathesis catalysts. We herein report the facile syntheses of cationic ruthenium catalysts bearing bulky phosphine ligands. Simple ligand exchange using silver(i) salts of non-coordinating or weakly coordinating anions provided either PPh3 or chelating Ph2P(CH2)nPPh2 (n = 2 or 3) ligated cationic catalysts. The structures of these newly reported catalysts feature unique geometries caused by ligation of the bulky phosphine ligands. Their activities and selectivities in standard metathesis reactions were also investigated. These cationic ruthenium alkylidene catalysts reported here showed moderate activity and very similar stereoselectivity when compared to the second generation ruthenium dichloride catalyst in ring-closing metathesis, cross metathesis, and ring-opening metathesis polymerization assays.

  12. Control concepts for active magnetic bearings

    Science.gov (United States)

    Siegwart, Roland; Vischer, D.; Larsonneur, R.; Herzog, R.; Traxler, Alfons; Bleuler, H.; Schweitzer, G.

    1992-01-01

    Active Magnetic Bearings (AMB) are becoming increasingly significant for various industrial applications. Examples are turbo-compressors, centrifuges, high speed milling and grinding spindles, vibration isolation, linear guides, magnetically levitated trains, vacuum and space applications. Thanks to the rapid progress and drastic cost reduction in power- and micro-electronics, the number of AMB applications is growing very rapidly. Industrial uses of AMBs leads to new requirements for AMB-actuators, sensor systems, and rotor dynamics. Especially desirable are new and better control concepts to meet demand such as low cost AMB, high stiffness, high performance, high robustness, high damping up to several kHz, vibration isolation, force-free rotation, and unbalance cancellation. This paper surveys various control concepts for AMBs and discusses their advantages and disadvantages. Theoretical and experimental results are presented.

  13. Water bearing halites: Oases of Mars?

    Science.gov (United States)

    Vreeland, R. H.; Rosenzweig, W. D.; Jones, J.; Krammes, J.; Monson, A.; Lowenstein, T.; Satterfield, C.; Timofeeff, M.

    2003-12-01

    Without liquid water there can be no life as we know it. This tenet focuses our search for extraterrestrial life on celestial bodies that had, or may still have, this essential substance. Searching for extraterrestrial life means selecting samples likely to protect water this requires reaching water containing perma-frosts, underground aquifers, or evaporites. Assuming one finds life similar to that on Earth how can we know it is from another planet and not contamination? This paper focuses on recent isolations of living microbes from halite that is at least 250 million years old. The presentation traces the recent data and theoretical considerations providing evidence for the age of the microbe, differences between it and modern relatives and its survival within water-bearing minerals. The evidence that evaporites may be a natural mechanism for maintaining life under adverse conditions is compelling and suggests that similar materials may be targets on Mars and elsewhere.

  14. Grizzly bears (Ursus arctos horribilis) and black bears (Ursus americanus) prevent trabecular bone loss during disuse (hibernation).

    Science.gov (United States)

    McGee-Lawrence, Meghan E; Wojda, Samantha J; Barlow, Lindsay N; Drummer, Thomas D; Castillo, Alesha B; Kennedy, Oran; Condon, Keith W; Auger, Janene; Black, Hal L; Nelson, O Lynne; Robbins, Charles T; Donahue, Seth W

    2009-12-01

    Disuse typically causes an imbalance in bone formation and bone resorption, leading to losses of cortical and trabecular bone. In contrast, bears maintain balanced intracortical remodeling and prevent cortical bone loss during disuse (hibernation). Trabecular bone, however, is more detrimentally affected than cortical bone in other animal models of disuse. Here we investigated the effects of hibernation on bone remodeling, architectural properties, and mineral density of grizzly bear (Ursus arctos horribilis) and black bear (Ursus americanus) trabecular bone in several skeletal locations. There were no differences in bone volume fraction or tissue mineral density between hibernating and active bears or between pre- and post-hibernation bears in the ilium, distal femur, or calcaneus. Though indices of cellular activity level (mineral apposition rate, osteoid thickness) decreased, trabecular bone resorption and formation indices remained balanced in hibernating grizzly bears. These data suggest that bears prevent bone loss during disuse by maintaining a balance between bone formation and bone resorption, which consequently preserves bone structure and strength. Further investigation of bone metabolism in hibernating bears may lead to the translation of mechanisms preventing disuse-induced bone loss in bears into novel treatments for osteoporosis.

  15. A new method for studying the 3D transient flow of misaligned journal bearings in flexible rotor-bearing systems

    Institute of Scientific and Technical Information of China (English)

    Qiang LI; Shu-lian LIU; Xiao-hong PAN; Shui-ying ZHENG

    2012-01-01

    The effects of journal misalignment on the transient flow of a finite grooved journal bearing are presented in this study.A new 3D computational fluid dynamics (CFD) analysis method is applied.Also,the quasi-coupling calculation of transient fluid dynamics of oil film in journal bearing and rotor dynamics is considered in the analysis.Based on the structured mesh,a new approach for mesh movement is proposed to update the mesh volume when the journal moves during the fluid dynamics simulation of an oil film.Existing dynamic mesh models provided by FLUENT are not suitable for the transient oil flow in journal bearings.The movement of the journal is obtained by solving the moving equations of the rotor-bearing system with the calculated film pressure as the boundary condition of the load.The data exchange between fluid dynamics and rotor dynamics is realized by data files.Results obtained from the CFD model were consistent with previous experimental results on misalignedjournal bearings.Film pressure,oil film force,friction torque,misalignment moment and attitude angle were calculated and compared for misaligned and aligned journal bearings.The results indicate that bearing performances are greatly affected by misalignment which is caused by unbalanced excitation,and the CFD method based on the fluid-structure interaction (FSI) technique can effectively predict the transient flow field ofa misaligned journal bearing in a rotor-bearing system.

  16. The Effect of Non-Circular Bearing Shapes in Hydrodynamic Journal Bearings on the Vibration Behavior of Turbocharger Structures

    Directory of Open Access Journals (Sweden)

    Lukas Bernhauser

    2017-03-01

    Full Text Available Increasing quality demands of combustion engines require, amongst others, improvements of the engine’s acoustics and all (subcomponents mounted to the latter. A significant impact to the audible tonal noise spectrum results from the vibratory motions of fast-rotating turbocharger rotor systems in multiple hydrodynamic bearings such as floating bearing rings. Particularly, the study of self-excited non-linear vibrations of the rotor-bearing systems is crucial for the understanding, prevention or reduction of the noise and, consequently, for a sustainable engine acoustics development. This work presents an efficient modeling approach for the investigation, optimization, and design improvement of complex turbocharger rotors in hydrodynamic journal bearings, including floating bearing rings with circular and non-circular bearing geometries. The capability of tonal non-synchronous vibration prevention using non-circular bearing shapes is demonstrated with dynamic run-up simulations of the presented model. These findings and the performance of our model are compared and validated with results of a classical Laval/Jeffcott rotor-bearing model and a specific turbocharger model found in the literature. It is shown that the presented simulation method yields fast and accurate results and furthermore, that non-circular bearing shapes are an effective measure to reduce or even prevent self-excited tonal noise.

  17. Gulf-Wide Information System, Environmental Sensitivity Index Bear Database, Geographic NAD83, LDWF (2001) [esi_bear_LDWF_2001

    Data.gov (United States)

    Louisiana Geographic Information Center — This data set contains sensitive biological resource data for the Louisiana black bear in coastal Louisiana. Vector polygons represent occupied habitat for this...

  18. Dynamic behavior of a magnetic bearing supported jet engine rotor with auxiliary bearings

    Science.gov (United States)

    Flowers, George T.; Xie, Huajun; Sinha, S. C.

    1995-01-01

    This paper presents a study of the dynamic behavior of a rotor system supported by auxiliary bearings. The steady-state behavior of a simulation model based upon a production jet engine is explored over a wide range of operating conditions for varying rotor imbalance, support stiffness, and damping. Interesting dynamical phenomena, such as chaos, subharmonic responses, and double-valued responses, are presented and discussed.

  19. Seasonal carbohydrate storage and mobilization in bearing and non-bearing pistachio (Pistacia vera) trees.

    Science.gov (United States)

    Spann, Timothy M; Beede, Robert H; Dejong, Theodore M

    2008-02-01

    We analyzed annual carbohydrate storage and mobilization of bearing ("on") and non-bearing ("off") 'Kerman' pistachio (Pistacia vera L.) trees growing on three different rootstocks. On all rootstocks, carbohydrate storage in shoots and branches of "on" and "off" trees was lowest following the spring growth flush. In "off" trees, stored carbohydrates increased and remained high after the initial growth flush. In "on" trees, stem carbohydrates increased temporarily in early summer, but were mobilized in mid-season during kernel fill, and then increased again after nut harvest. During the dormant season, the only substantial differences in carbohydrate storage between previously "on" and "off" trees were found in the roots of the weakest rootstock. The annual carbohydrate storage and mobilization pattern in canopy branches of heavily cropped pistachio trees appeared to be driven by carbohydrate demands related to nut development and untempered by tree vigor. Mobilization of carbohydrates from current-season and 1- and 2-year-old stem wood of "on" trees during the primary period of kernel fill corresponded with the period of inflorescence bud abscission. Thus, the alternate bearing pattern associated with inflorescence bud abscission in 'Kerman' pistachio may be a function of mid-season mobilization of stored carbohydrates in current-season stems resulting in stimulation of inflorescence bud abscission.

  20. Grizzly bear nutrition and ecology studies in Yellowstone National Park

    Science.gov (United States)

    Robbins, Charles T.; Schwartz, Charles C.; Gunther, Kerry A.; Servheen, Christopher

    2006-01-01

    T HE CHANCE TO SEE a wild grizzly bear is often the first or second reason people give for visiting Yellow - stone National Park. Public interest in bears is closely coupled with a desire to perpetuate this wild symbol of the American West. Grizzly bears have long been described as a wilderness species requiring large tracts of undisturbed habitat. However, in today’s world, most grizzly bears live in close proximity to humans (Schwartz et al. 2003). Even in Yellowstone National Park, the impacts of humans can affect the long-term survival of bears (Gunther et al. 2002). As a consequence, the park has long supported grizzly bear research in an effort to understand these impacts. Most people are familiar with what happened when the park and the State of Montana closed open-pit garbage dumps in the late 1960s and early 1970s, when at least 229 bears died as a direct result of conflict with humans. However, many may not be as familiar with the ongoing changes in the park’s plant and animal communities that have the potential to further alter the park’s ability to support grizzly bears.