WorldWideScience

Sample records for beam therapy facility

  1. Proton beam therapy facility

    International Nuclear Information System (INIS)

    It is proposed to build a regional outpatient medical clinic at the Fermi National Accelerator Laboratory (Fermilab), Batavia, Illinois, to exploit the unique therapeutic characteristics of high energy proton beams. The Fermilab location for a proton therapy facility (PTF) is being chosen for reasons ranging from lower total construction and operating costs and the availability of sophisticated technical support to a location with good access to patients from the Chicago area and from the entire nation. 9 refs., 4 figs., 26 tabs

  2. Treatment facilities, human resource development, and future prospect of particle beam therapy

    International Nuclear Information System (INIS)

    The number of particle beam therapy facilities is increasing globally. Among the countries practicing particle beam therapy, Japan is one of the leading countries in the field with four operating carbon-ion therapy facilities and ten operating proton therapy facilities. With the increasing number of particle beam therapy facilities, the human resource development is becoming extremely important, and there has been many such efforts including the Gunma University Program for Cultivating Global Leaders in Heavy Ion Therapeutics and Engineering, which aimed to educate and train the radiation oncologists, medical physicists, accelerator engineers, and radiation biologists to become global leaders in the field of particle beam therapy. In the future, the benefit and effectiveness of particle beam therapy should be discussed and elucidated objectively in a framework of comprehensive cancer care. (author)

  3. Neutron Therapy Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Neutron Therapy Facility provides a moderate intensity, broad energy spectrum neutron beam that can be used for short term irradiations for radiobiology (cells)...

  4. Opening and construction of facilities in succession for particle beam therapy of cancer

    International Nuclear Information System (INIS)

    This feature article describes the current state of practical particle beam therapy of cancer, its future prospect, recent opening/construction of its facilities and manufacturers' view with following 9 topics presented by relevant experts. Gunma University (topic 1) started the carbon ion therapy from Mar., 2010, and has treated more than 100 cancer patients to aim the treatment of about 600 patients/year after several years. Fukui Prefectural Hospital Proton Therapy Center (topic 2) started from this March with proton beams for patients with its therapeutic standard, in cooperation with insurance companies and hotels for patients' convenience. Medipolis Proton Therapy and Research Center (Kagoshima Pref.) (topic 3) started this year with proton beams for 13 patients hitherto with reference protocol of Hyogo Ion Beam Medical Center. A new stereotactic irradiation system of proton beams for breast cancer has been developed. Construction of Saga Heavy Ion Medical Accelerator in Tosu (Saga Pref.) (topic 4) began this year to be completed in 2013. Aizawa Hospital (Nagano Pref.) (topic 5) plans to introduce the small-sized proton accelerator-gantry system (Sumitomo Heavy Ind., Ltd.) aiming the practice in 2013. Association for Nuclear Technology in Medicine (topic 6) reports the trends of current and future construction inside/outside Japan. Manufacturers comment their respective business: high-speed scanning irradiation system, next generation handling system of patient and particle beam therapy information system by Toshiba (topic 7); designation of the whole heavy ion beam therapy system (with NIRS), proton beam (as in topic 5) and system of BNCT (boron neutron-capture therapy) (Kyoto Univ.) by Sumitomo Heavy Ind., Ltd. (topic 8); and small-size proton therapeutic machine with 4D tracing capability for patient's movement (Hokkaido Univ.) and with spot-scanning irradiation technique by Hitachi (topic 9). (author)

  5. A Dual-Beam Irradiation Facility for a Novel Hybrid Cancer Therapy

    CERN Document Server

    Sabchevski, Svilen; Ishiyama, Shintaro; Miyoshi, Norio; Tatsukawa, Toshiaki

    2012-01-01

    In this paper we present the main ideas and discuss both the feasibility and the conceptual design of a novel hybrid technique and equipment for an experimental cancer therapy based on the simultaneous and/or sequential application of two beams, namely a beam of neutrons and a CW (continuous wave) or intermittent sub-terahertz wave beam produced by a gyrotron for treatment of cancerous tumors. The main simulation tools for the development of the computer aided design (CAD) of the prospective experimental facility for clinical trials and study of such new medical technology are briefly reviewed. Some tasks for a further continuation of this feasibility analysis are formulated as well.

  6. Dosimetric characteristics of the thermal neutron beam facility for neutron capture therapy at Hanaro reactor

    International Nuclear Information System (INIS)

    The thermal neutron beam facility utilizing a typical tangential beam port for Neutron Capture Therapy was installed at the Hanaro, 30 MW multi-purpose research reactor. In order to determine the different dose components in phantoms irradiated with a mixed thermal neutron beam and gamma-ray for clinical applications, various techniques were applied including the use of activation foils, TLDs and ionization chambers. The water phantom was utilized in the measurement. The results of the measurement were compared with MCNP4B calculations. The thermal neutron fluxes were 1.02E9 and 6.07E8/cm2·s at 10 and 20 mm depth in water, respectively. The gamma-ray dose rate was 5.10 Gy/hr at 20 mm depth in water. The result of this study can be used as basic data for subsequent BNCT clinical application. (author)

  7. External Beam Therapy (EBT)

    Science.gov (United States)

    ... Physician Resources Professions Site Index A-Z External Beam Therapy (EBT) External beam therapy (EBT) is a ... follow-up should I expect? What is external beam therapy and how is it used? External beam ...

  8. 1000 MeV Proton beam therapy facility at Petersburg Nuclear Physics Institute Synchrocyclotron

    Science.gov (United States)

    Abrosimov, N. K.; Gavrikov, Yu A.; Ivanov, E. M.; Karlin, D. L.; Khanzadeev, A. V.; Yalynych, N. N.; Riabov, G. A.; Seliverstov, D. M.; Vinogradov, V. M.

    2006-05-01

    Since 1975 proton beam of PNPI synchrocyclotron with fixed energy of 1000 MeV is used for the stereotaxic proton therapy of different head brain diseases. 1300 patients have been treated during this time. The advantage of high energy beam (1000 MeV) is low scattering of protons in the irradiated tissue. This factor allows to form the dose field with high edge gradients (20%/mm) that is especially important for the irradiation of the intra-cranium targets placed in immediate proximity to the life critical parts of the brain. Fixation of the 6 0mm diameter proton beam at the isodose centre with accuracy of ±1.0 mm, two-dimensional rotation technique of the irradiation provide a very high ratio of the dose in the irradiation zone to the dose at the object's surface equal to 200:1. The absorbed doses are: 120-150 Gy for normal hypophysis, 100-120 Gy for pituitary adenomas and 40-70 Gy for arterio-venous malformation at the rate of absorbed dose up to 50 Gy/min. In the paper the dynamics and the efficiency of 1000 MeV proton therapy treatment of the brain deceases are given. At present time the feasibility study is in progress with the goal to create a proton therapy on Bragg peak by means of the moderation of 1000 MeV proton beam in the absorber down to 200 MeV, energy required for radiotherapy of deep seated tumors.

  9. 1000 MeV Proton beam therapy facility at Petersburg Nuclear Physics Institute Synchrocyclotron

    Energy Technology Data Exchange (ETDEWEB)

    Abrosimov, N K [Petersburg Nuclear Physics Institute, 188300 Gatchina (Russian Federation); Gavrikov, Yu A [Petersburg Nuclear Physics Institute, 188300 Gatchina (Russian Federation); Ivanov, E M [Petersburg Nuclear Physics Institute, 188300 Gatchina (Russian Federation); Karlin, D L [Central Research Institute of Roentgenology and Radiology, 197758, St.Petersburg (Russian Federation); Khanzadeev, A V [Petersburg Nuclear Physics Institute, 188300 Gatchina (Russian Federation); Yalynych, N N [Central Research Institute of Roentgenology and Radiology, 197758, St. Petersburg (Russian Federation); Riabov, G A [Petersburg Nuclear Physics Institute, 188300 Gatchina (Russian Federation); Seliverstov, D M [Petersburg Nuclear Physics Institute, 188300 Gatchina (Russian Federation); Vinogradov, V M [Central Research Institute of Roentgenology and Radiology, 197758, St.Petersburg (Russian Federation)

    2006-05-15

    Since 1975 proton beam of PNPI synchrocyclotron with fixed energy of 1000 MeV is used for the stereotaxic proton therapy of different head brain diseases. 1300 patients have been treated during this time. The advantage of high energy beam (1000 MeV) is low scattering of protons in the irradiated tissue. This factor allows to form the dose field with high edge gradients (20%/mm) that is especially important for the irradiation of the intra-cranium targets placed in immediate proximity to the life critical parts of the brain. Fixation of the 6 0mm diameter proton beam at the isodose centre with accuracy of {+-}1.0 mm, two-dimensional rotation technique of the irradiation provide a very high ratio of the dose in the irradiation zone to the dose at the object's surface equal to 200:1. The absorbed doses are: 120-150 Gy for normal hypophysis, 100-120 Gy for pituitary adenomas and 40-70 Gy for arterio-venous malformation at the rate of absorbed dose up to 50 Gy/min. In the paper the dynamics and the efficiency of 1000 MeV proton therapy treatment of the brain deceases are given. At present time the feasibility study is in progress with the goal to create a proton therapy on Bragg peak by means of the moderation of 1000 MeV proton beam in the absorber down to 200 MeV, energy required for radiotherapy of deep seated tumors.

  10. Electrostatic design and beam transport for a folded tandem electrostatic quadrupole accelerator facility for accelerator-based boron neutron capture therapy

    International Nuclear Information System (INIS)

    Within the frame of an ongoing project to develop a folded Tandem-Electrostatic-Quadrupole (TESQ) accelerator facility for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT), we discuss here the electrostatic design of the machine, including the accelerator tubes with electrostatic quadrupoles and the simulations for the transport and acceleration of a high intensity beam.

  11. Getting Ready for Ion-Beam Therapy Research in Austria - Building-up Research in Parallel with a Facility

    International Nuclear Information System (INIS)

    With participation in ion-beam projects funded nationally or by the European Commission (EC), ion-beam research activities were started at the Medical University of Vienna in parallel with the design and construction of the ion-beam center MedAustron in Wiener Neustadt, 50 km from the Austrian capital. The current medical radiation physics research activities that will be presented comprise: (1) Dose calculation and optimization: ion-beam centers focus mostly on proton and carbon-ion therapy. However, there are other ion species with great potential for clinical applications. Helium ions are currently under investigation from a theoretical physics and biology perspective. (2) Image guided and adaptive ion-beam therapy: organ motion and anatomic changes have a severe influence in ion-beam therapy since variations in heterogeneity along the beam path have a significant impact on the particle range. Ongoing research focuses on possibilities to account for temporal variations of the anatomy during radiotherapy. Both during and between fractions also considering temporal variations in tumor biology. Furthermore, research focuses on particle therapy positron emission tomography (PT-PET) verification and the detection of prompt gammas for on-line verification of ion-beam delivery. (3) Basic and applied dosimetry: an end-to-end procedure was designed and successfully tested in both scanned proton and carbon-ion beams, which may also serve as a dosimetric credentialing procedure for clinical trials in the future. (Author)

  12. Laser Produced Ions as an Injection Beam for Cancer Therapy Facility

    CERN Document Server

    Noda, A; Iwashita, Y; Nakamura, S; Sakabe, S; Shimizu, S; Shirai, T; Tongu, H

    2004-01-01

    Ion production from a solid target by a high-power short pulse laser has been investigated to replace the injector linac of the synchrotron dedicated for cancer therapy. As the high power laser, the laser with the peak power of 100 TW and minimum pulse duration of 20 fs which has been developed at JAERI Kansai Research Establishment, is assumed. Laser produced ions with 100% energy spread is energy selected within ±5% and then phase rotated with use of the RF electric field synchronized to the pulse laser, which further reduces the energy spread to ±1%. The scheme of the phase rotation is presented together with the experimental results of laser production from the thin foil target.

  13. Fan-beam intensity modulated proton therapy

    OpenAIRE

    Hill, Patrick; Westerly, David; Mackie, Thomas

    2013-01-01

    Purpose: This paper presents a concept for a proton therapy system capable of delivering intensity modulated proton therapy using a fan beam of protons. This system would allow present and future gantry-based facilities to deliver state-of-the-art proton therapy with the greater normal tissue sparing made possible by intensity modulation techniques.

  14. Proton beam therapy

    OpenAIRE

    Levin, W P; Kooy, H; Loeffler, J S; T. F. DeLaney

    2005-01-01

    Conventional radiation therapy directs photons (X-rays) and electrons at tumours with the intent of eradicating the neoplastic tissue while preserving adjacent normal tissue. Radiation-induced damage to healthy tissue and second malignancies are always a concern, however, when administering radiation. Proton beam radiotherapy, one form of charged particle therapy, allows for excellent dose distributions, with the added benefit of no exit dose. These characteristics make this form of radiother...

  15. Quality assurance for particle beam therapy

    International Nuclear Information System (INIS)

    In radiation therapy, it is essential that a prescribed target area is irradiated with the prescribed dose concentration to reduce the possibility cancer reoccurrence or to mitigate its side effects. Particle beam therapy is a high accuracy radiation therapy, which has superior characteristics. Specifically, a high dose region, namely, Bragg peak formed around the beam stopping point can be adjusted to the target volume. The routine of particle beam therapy should be performed with various verifications, called quality assurance(QA), at its each step, i.e., treatment planning, dosimetry, patient positioning and respiratory gating system. Each particle beam therapy facility should have and conduct its own QA program. Methods and materials for the QA should be developed according to the progress of techniques in particle beam therapy. (author)

  16. Technical design of hadron therapy facilities

    International Nuclear Information System (INIS)

    Radiation therapy with hadron beams now has a 40-year track record at many accelerator laboratories around the world, essentially all of these originally physics-research oriented. The great promise shown for treating cancer has led the medical community to seek dedicated accelerator facilities in a hospital setting, where more rapid progress can be made in clinical research. This paper will discuss accelerator and beam characteristics relevant to hadron therapy, particularly as applied to hospital-based facilities. A survey of currently-operating and planned hadron therapy facilities will be given, with particular emphasis on Loma Linda (the first dedicated proton facility in a hospital) and HIMAC (the first dedicated heavy-ion medical facility)

  17. Technical Design of Hadron Therapy Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Alonso, J.R.

    1993-08-01

    Radiation therapy with hadron beams now has a 40-year track record at many accelerator laboratories around the world, essentially all of these originally physics-research oriented. The great promise shown for treating cancer has led the medical community to seek dedicated accelerator facilities in a hospital setting, where more rapid progress can be made in clinical research. This paper will discuss accelerator and beam characteristics relevant to hadron therapy, particularly as applied to hospital-based facilities. A survey of currently-operating and planned hadron therapy facilities will be given, with particular emphasis on Lorna Linda (the first dedicated proton facility in a hospital) and HIMAC (the first dedicated heavy-ion medical facility).

  18. Technical design of hadron therapy facilities

    Energy Technology Data Exchange (ETDEWEB)

    Alonso, J.R.

    1993-08-01

    Radiation therapy with hadron beams now has a 40-year track record at many accelerator laboratories around the world, essentially all of these originally physics-research oriented. The great promise shown for treating cancer has led the medical community to seek dedicated accelerator facilities in a hospital setting, where more rapid progress can be made in clinical research. This paper will discuss accelerator and beam characteristics relevant to hadron therapy, particularly as applied to hospital-based facilities. A survey of currently-operating and planned hadron therapy facilities will be given, with particular emphasis on Loma Linda (the first dedicated proton facility in a hospital) and HIMAC (the first dedicated heavy-ion medical facility).

  19. Cluster ion beam facilities

    International Nuclear Information System (INIS)

    A brief state-of-the-art review in the field of cluster-surface interactions is presented. Ionised cluster beams could become a powerful and versatile tool for the modification and processing of surfaces as an alternative to ion implantation and ion assisted deposition. The main effects of cluster-surface collisions and possible applications of cluster ion beams are discussed. The outlooks of the Cluster Implantation and Deposition Apparatus (CIDA) being developed in Guteborg University are shown

  20. Overview of light-ion beam therapy

    International Nuclear Information System (INIS)

    This overview of light-ion beam therapy covers the following topics: a history of hadron therapy, light-ion beam therapy, beam fragmentation, the biological rationale for the clinical use of light ions, the physical parameters of clinical beams, distributions of relative biological effectiveness (RBE) and linear energy transfer (LET), verification of treatment planning and delivery using charged particle beams, ion beam research in space biology, clinical trials using light ions, and the relationship between the present report and other IAEA and ICRU reports. There are plans for four national centres using light ions, in Germany, France, Austria, and Italy. There is an increasing interest in further initiatives and more countries are expressing interest in creating national projects, in particular Sweden, the Netherlands, Belgium, Spain and the UK. In Japan, another carbon-ion therapy facility project has started, and three additional facilities are planned. There are other initiatives for light-ion facilities in several locations in the USA, in China, and in Korea. (author)

  1. Beam Characterizations at Femtosecond Electron Beam Facility

    CERN Document Server

    Rimjaem, Sakhorn; Kangrang, Nopadol; Kusoljariyakul, Keerati; Rhodes, Michael W; Saisut, Jatuporn; Thongbai, Chitrlada; Vilaithong, Thiraphat; Wichaisirimongkol, Pathom; Wiedemann, Helmut

    2005-01-01

    The SURIYA project at the Fast Neutron Research Facility (FNRF) has been established and is being commissioning to generate femtosecond electron pulses. Theses short pulses are produced by a system consisting of an S-band thermionic cathode RF-gun, an alpha magnet as a magnetic bunch compressor, and a linear accelerator. The characteristics of its major components and the beam characterizations as well as the preliminary experimental results will be presented and discussed.

  2. The effect of an analyzed deuterium ion beam on the lifetime of TiT targets used at the fast neutron therapy facility (DT, 14 MeV) Hamburg-Eppendorf

    International Nuclear Information System (INIS)

    Report on experiments performed with mixed or analyzed deuterium ion beams incident on TiT targets at the neutron therapy facility Hamburg-Eppendord. Bombarding a TiT target area with all separated atomic and molescular ions of an analyzed deuterium ion beam at different beam spots, the 'initial' half-life of the used tritium target increases with a factor of more than three as against the half-life obtained with a mixed deuterium ion beam at a single beam spot. In this case, the effective target current is not reduced and in the same order as that for a mixed deuterium ion beam. Using the atomic deuterons only, the increase of the 'initial' half-life is far longer yet, but the loss in target current is about 50% dependent on the reduction of molecular deuterium ions. These facts are most important for the economy of this type of neutron therapy facilities in clinical work. (orig.)

  3. Triple ion beam irradiation facility

    International Nuclear Information System (INIS)

    A unique ion irradiation facility consisting of three accelerators is described. The accelerators can be operated simultaneously to deliver three ion beams on one target sample. The energy ranges of the ions are 50 to 400 keV, 200 keV to 2.5 MeV, and 1.0 to 5.0 MeV. Three different ions in the appropriate mass range can be simultaneously implanted to the same depth in a target specimen as large as 100 mm2 in area. Typical depth ranges are 0.1 to 1.0 μm. The X-Y profiles of all three ion beams are measured by a system of miniature Faraday cups. The low-voltage accelerator can periodically ramp the ion beam energy during the implantation. Three different types of target chambers are in use at this facility. The triple-beam high-vacuum chamber can hold nine transmission electron microscopy specimens at elevated temperature during a irradiation by the three simultaneous beams. A second high-vacuum chamber on the medium-voltage accelerator beamline houses a low- and high-temperature translator and a two-axis goniometer for ion channeling measurements. The third chamber on the high-energy beamline can be gas-filled for special stressed specimen irradiations. Special applications for the surface modification of materials with this facility are described. Appendixes containing operating procedures are also included. 18 refs., 27 figs., 1 tab

  4. Radiation therapy facilities in the United States

    International Nuclear Information System (INIS)

    Purpose: About half of all cancer patients in the United States receive radiation therapy as a part of their cancer treatment. Little is known, however, about the facilities that currently deliver external beam radiation. Our goal was to construct a comprehensive database of all radiation therapy facilities in the United States that can be used for future health services research in radiation oncology. Methods and Materials: From each state's health department we obtained a list of all facilities that have a linear accelerator or provide radiation therapy. We merged these state lists with information from the American Hospital Association (AHA), as well as 2 organizations that audit the accuracy of radiation machines: the Radiologic Physics Center (RPC) and Radiation Dosimetry Services (RDS). The comprehensive database included all unique facilities listed in 1 or more of the 4 sources. Results: We identified 2,246 radiation therapy facilities operating in the United States as of 2004-2005. Of these, 448 (20%) facilities were identified through state health department records alone and were not listed in any other data source. Conclusions: Determining the location of the 2,246 radiation facilities in the United States is a first step in providing important information to radiation oncologists and policymakers concerned with access to radiation therapy services, the distribution of health care resources, and the quality of cancer care

  5. SU-E-T-388: Estimating the Radioactivity Inventory of a Cyclotron Based Pencil Beam Proton Therapy Facility

    International Nuclear Information System (INIS)

    Purpose: Parts of the cyclotron and energy degrader are incidentally activated by protons lost during the acceleration and transport of protons for radiation therapy. An understanding of the radioactive material inventory is needed when regulatory requirements are assessed. Methods: First, the tumor dose and volume is used to determine the required energy deposition. For spot scanning, the tumor length along the beam path determines the number of required energy layers. For each energy layer the energy deposition per proton can be calculated from the residual proton range within the tumor. Assuming a typical layer weighting, an effective energy deposition per proton can then be calculated. The total number of required protons and the number of protons per energy layer can then be calculated. For each energy layer, proton losses in the energy degrader are calculated separately since its transmission efficiency, and hence the amount of protons lost, is energy dependent. The degrader efficiency also determines the number of protons requested from the cyclotron. The cyclotron extraction efficiency allows a calculation of the proton losses within the cyclotron. The saturation activity induced in the cyclotron and the degrader is equal to the production rate R for isotopes whose half-life is shorter that the projected cyclotron life time. R can be calculated from the proton loss rate and published production cross sections. Results: About 1/3 of the saturation activity is produced in the cyclotron and 2/3 in the energy degrader. For a projected case mix and a patient load of 1100 fractions per week at 1.8 Gy per fraction a combined activity of 180 mCi was estimated at saturation. Conclusion: Calculations were used to support to application of a radioactive materials license for the possession of 200 mCi of activity for isotopes with atomic numbers ranging from 1-83

  6. Development of cancer therapy facility of HANARO

    International Nuclear Information System (INIS)

    Facilities of the research and clinical treatments of neutron capture therapy using HANARO are developed, and they are ready to install. They are BNCT irradiation facility and prompt gamma neutron activatiion analysis facility. Since every horizontal neutron facility of HANARO is long and narrow tangential beam tube, it is analysed that sufficient epithermal neutrons for the BNCT cannot be obtained but sufficient thermal neutrons can be obtained by a filter composed of silicon and bismuth single crystals. Since the thermal neutron penetaration increases significantly when the crystals are cooled, a filter cooled by liquid nitrogen is developed. So as to avoid interference with the reactor operation, a water shutter is developed. The irradiation room is designed for the temporary surgical operation as well. Handling tools to remove activated beam port plug and to install water shutter and filter are developed. The basic structure of the irradiation room is already installed and most of other parts are ready to install. Since no free beam port is available for the prompt gamma neutron activation analysis, a method obtaining almost pure thermal neutrons by the vertical diffraction of extra beam for the polarized neutron spectrometer is developed. This method is confirmed by analysis and experiments to give high enough neutron beam. Equipment and devices are provided to install this facility

  7. Electron beams in radiation therapy

    International Nuclear Information System (INIS)

    Clinical electron beams in interaction with beam flattening and collimating devices are studied, in order to obtain the means for adequate electron therapy. A treatment planning method for arbitrary field shapes is developed that takes the properties of the collimated electron beams into account. An electron multiple-scattering model is extended to incorporate a model for the loss of electrons with depth, in order to improve electron beam dose planning. A study of ionisation measurements in two different phantom materials yields correction factors for electron beam dosimetry. (Auth.)

  8. General considerations for neutron capture therapy at a reactor facility

    International Nuclear Information System (INIS)

    In addition to neutron beam intensity and quality, there are also a number of other significant criteria related to a nuclear reactor that contribute to a successful neutron capture therapy (NCT) facility. These criteria are classified into four main categories: Nuclear design factors, facility management and operations factors, facility resources, and non-technical factors. Important factors to consider are given for each of these categories. In addition to an adequate neutron beam intensity and quality, key requirements for a successful neutron capture therapy facility include necessary finances to construct or convert a facility for NCT, a capable medical staff to perform the NCT, and the administrative support for the facility. The absence of any one of these four factors seriously jeopardizes the overall probability of success of the facility. Thus nuclear reactor facility management considering becoming involved in neutron capture therapy, should it be proven clinically successful, should take all these factors into consideration. (author)

  9. Facilities for radiotherapy with ion beams status and worldwide developments

    CERN Document Server

    Wolf, B H

    1999-01-01

    Forty-five years after the first ion beam therapy in Berkeley around 25,000 cancer patients worldwide have been treated successfully. Ion accelerators, designed for nuclear research, delivered most of this treatment. The first hospital-based facility started operation in 1998 at Loma Linda California, the first for heavier ions at Chiba, Japan in 1994 and the first commercially delivered facilities started operation in 1998 at Kashiwa, Japan. In 2000, the Harvard Medical Centre, Boston, US, will commence operation and several new facilities are planned or under construction worldwide, although none in Australia. This paper will discuss the physical and biological advantages of ion beams over x-rays and electrons. In the treatment of cancer patients ion beam therapy is especially suited for localised tumours in radiation sensitive areas like skull or spine. Heavier ions are also effective in anoxic tumour cells (found around the normally oxygenated cell population). An additional advantage of the heavier carbo...

  10. Fan-beam intensity modulated proton therapy

    International Nuclear Information System (INIS)

    Purpose: This paper presents a concept for a proton therapy system capable of delivering intensity modulated proton therapy using a fan beam of protons. This system would allow present and future gantry-based facilities to deliver state-of-the-art proton therapy with the greater normal tissue sparing made possible by intensity modulation techniques.Methods: A method for producing a divergent fan beam of protons using a pair of electromagnetic quadrupoles is described and particle transport through the quadrupole doublet is simulated using a commercially available software package. To manipulate the fan beam of protons, a modulation device is developed. This modulator inserts or retracts acrylic leaves of varying thickness from subsections of the fan beam. Each subsection, or beam channel, creates what effectively becomes a beam spot within the fan area. Each channel is able to provide 0–255 mm of range shift for its associated beam spot, or stop the beam and act as an intensity modulator. Results of particle transport simulations through the quadrupole system are incorporated into the MCNPX Monte Carlo transport code along with a model of the range and intensity modulation device. Several design parameters were investigated and optimized, culminating in the ability to create topotherapy treatment plans using distal-edge tracking on both phantom and patient datasets.Results: Beam transport calculations show that a pair of electromagnetic quadrupoles can be used to create a divergent fan beam of 200 MeV protons over a distance of 2.1 m. The quadrupole lengths were 30 and 48 cm, respectively, with transverse field gradients less than 20 T/m, which is within the range of water-cooled magnets for the quadrupole radii used. MCNPX simulations of topotherapy treatment plans suggest that, when using the distal edge tracking delivery method, many delivery angles are more important than insisting on narrow beam channel widths in order to obtain conformal target coverage

  11. The clinical case for proton beam therapy

    International Nuclear Information System (INIS)

    Over the past 20 years, several proton beam treatment programs have been implemented throughout the United States. Increasingly, the number of new programs under development is growing. Proton beam therapy has the potential for improving tumor control and survival through dose escalation. It also has potential for reducing harm to normal organs through dose reduction. However, proton beam therapy is more costly than conventional x-ray therapy. This increased cost may be offset by improved function, improved quality of life, and reduced costs related to treating the late effects of therapy. Clinical research opportunities are abundant to determine which patients will gain the most benefit from proton beam therapy. We review the clinical case for proton beam therapy. Proton beam therapy is a technically advanced and promising form of radiation therapy

  12. The clinical case for proton beam therapy

    Directory of Open Access Journals (Sweden)

    Foote Robert L

    2012-10-01

    Full Text Available Abstract Over the past 20 years, several proton beam treatment programs have been implemented throughout the United States. Increasingly, the number of new programs under development is growing. Proton beam therapy has the potential for improving tumor control and survival through dose escalation. It also has potential for reducing harm to normal organs through dose reduction. However, proton beam therapy is more costly than conventional x-ray therapy. This increased cost may be offset by improved function, improved quality of life, and reduced costs related to treating the late effects of therapy. Clinical research opportunities are abundant to determine which patients will gain the most benefit from proton beam therapy. We review the clinical case for proton beam therapy. Summary sentence Proton beam therapy is a technically advanced and promising form of radiation therapy.

  13. The use of recombination chambers at radiation therapy facilities

    Energy Technology Data Exchange (ETDEWEB)

    Zielczynski, Mieczyslaw [Institute of Atomic Energy, 05-400 Swierk (Poland); Golnik, Natalia, E-mail: golnik@mchtr.pw.edu.p [Institute of Metrology and Biomedical Engineering, Warsaw University of Technology, Sw. A. Boboli 8, 02-525 Warsaw (Poland); Gryzinski, Michal A. [Institute of Atomic Energy, 05-400 Swierk (Poland); Tulik, Piotr [Institute of Atomic Energy, 05-400 Swierk (Poland); Institute of Metrology and Biomedical Engineering, Warsaw University of Technology, Sw. A. Boboli 8, 02-525 Warsaw (Poland)

    2010-12-15

    The paper presents an overview of the applications of recombination chambers for dosimetric measurements at radiotherapy facilities. The chambers were used at electron, proton and heavy ion accelerators, in the beam and in the vicinity of the accelerators at very different dose rates. The examples of measurements discussed in the paper include: the determination of the absorbed dose and radiation quality parameters of a 170 MeV proton beam and BNCT (boron neutron capture therapy) beam, neutron dose measurements at a phantom surface outside the beam of a 15 MV electron medical accelerator, determination of ambient dose equivalent, H* (10) outside the irradiated phantom in the proton therapy treatment room at JINR (Dubna, Russia), and at working places outside the shielding of the heavy ion therapy facility at GSI (Darmstadt, Germany).

  14. The use of recombination chambers at radiation therapy facilities

    International Nuclear Information System (INIS)

    The paper presents an overview of the applications of recombination chambers for dosimetric measurements at radiotherapy facilities. The chambers were used at electron, proton and heavy ion accelerators, in the beam and in the vicinity of the accelerators at very different dose rates. The examples of measurements discussed in the paper include: the determination of the absorbed dose and radiation quality parameters of a 170 MeV proton beam and BNCT (boron neutron capture therapy) beam, neutron dose measurements at a phantom surface outside the beam of a 15 MV electron medical accelerator, determination of ambient dose equivalent, H* (10) outside the irradiated phantom in the proton therapy treatment room at JINR (Dubna, Russia), and at working places outside the shielding of the heavy ion therapy facility at GSI (Darmstadt, Germany).

  15. Radiation therapy apparatus having retractable beam stopper

    International Nuclear Information System (INIS)

    This invention relates to a radiation therapy apparatus which utilized a linear translation mechanism for positioning a beam stopper. An apparatus is described wherein the beam stopper is pivotally attached to the therapy machine with an associated drive motor in such a way that the beam stopper retracts linearly

  16. Fragmentation in Carbon Therapy Beams

    CERN Document Server

    Charara, Y M

    2010-01-01

    The state of the art Monte Carlo code HETC-HEDS was used to simulate spallation products, secondary neutron, and secondary proton production in A-150 Tissue Equivalent Plastic phantoms to investigate fragmentation of carbon therapy beams. For a 356 MeV/Nucleon carbon ion beam, production of charged particles heavier than protons was 0.24 spallation products per incident carbon ion with atomic numbers ranging from 1 through 5 (hydrogen to boron). In addition, there were 4.73 neutrons and 2.95 protons produced per incident carbon ion. Furthermore, as the incident energy increases, the neutron production rate increases at a rate of 20% per 10 MeV/nucleon. Secondary protons were created at a rate between 2.62-2.87 per carbon ion, while spallation products were created at a rate between 0.20-0.24 per carbon ion.

  17. Proton beam therapy control system

    Science.gov (United States)

    Baumann, Michael A.; Beloussov, Alexandre V.; Bakir, Julide; Armon, Deganit; Olsen, Howard B.; Salem, Dana

    2008-07-08

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  18. Carbon Beam Radio-Therapy and Research Activities at HIMAC

    International Nuclear Information System (INIS)

    Radio-therapy with carbon ion beam has been carried out since 1994 at HIMAC (Heavy Ion Medical Accelerator in Chiba) in NIRS (National Institute of Radiological Sciences). Now, many types of tumors can be treated with carbon beam with excellent local controls of the tumors. Stimulated with good clinical results, requirement of the dedicated compact facility for carbon beam radio-therapy is increased. To realize this requirement, design study of the facility and the R and D's of the key components in this design are promoted by NIRS. According successful results of these activities, the dedicated compact facility will be realized in Gunma University. In this facility, the established irradiation method is expected to use, which is passive irradiation method with wobbler magnets and ridge filter. In this presentation, above R and D's will be presented together with clinical results and basic research activities at HIMAC

  19. World new facilities for radioactive isotope beams

    International Nuclear Information System (INIS)

    The use of unstable nuclei in the form of energetic beams for nuclear physics studies is now entering into a new era. 'New-generation' facilities are either in operation, under construction or being planned. They are designed to provide radioactive isotope (RI) beams with very high intensities over a wide range of nuclides. These facilities are expected to provide opportunities to study nuclear structure, astrophysical nuclear processes and nuclear matter with large proton-neutron imbalance in grate detail. This article reports on the current status of such new-generation RI-beam facilities around the world. In order to cover different energy domains and to meet various scientific demands, the designs of RI-beam facilities are of a wide variety. For example, RIBF in Japan, FAIR in Germany and FRIB in US are based on the fragmentation scheme for beams with energies of a few hundred MeV/nucleon to GeV/nucleon, whereas Spiral2 in France, SPES in Italy, HIE-ISOLDE in Switzerland/France, and the future facility EURISOL in Europe are based on the ISOL method, and aim at providing lower-energy RI beams. There are a many other projects including upgrades of existing facilities in the three continents, America, Asia and Europe

  20. The Continuous Electron Beam Accelerator Facility

    International Nuclear Information System (INIS)

    On February 13, 1987, construction started on the Continuous Electron Beam Accelerator Facility - a 4-GeV, 200-μA, continuous beam, electron accelerator facility designed for nuclear physics research. The machine has a racetrack configuration with two antiparallel, 500-MeV, superconducting linac segments connected by beam lines to allow four passes of recirculation. The accelerating structure consists of 1500-MHz, five-cell niobium cavities developed at Cornell University. A liquid helium cryogenic system cools the cavities to an operating temperature of 2 K. Beam extraction after any three of the four passes allows simultaneous delivery of up to three beams of independently variable currents and different, but correlated, energies to the three experimental areas. Beam breakup thresholds exceed the design current by nearly two orders of magnitude. Project completion and the start of physics operations are scheduled for 1993. The total estimated cost is $255 million

  1. Proton beam therapy in the dermatological field

    International Nuclear Information System (INIS)

    Since 1983, a pilot study of proton beam therapy has been made at the Particle Radiation Medical Science Center (changed to the Proton Medical Research Center). This paper gives an outline of protom beam therapy for skin malignant tumor, with special reference to 24 patients treated during a period 1983-1990. These patients consisted of 4 with Bowen's disease, 5 with oral florid papillomatosis, 3 with spinocellular carcinoma, 9 with malignant melanoma, and 3 with other miscellaneous diseases. The outcome of proton beam therapy was satisfactory for Bowen's disease, controversial for both oral florid papillomatosis and spinocellular carcinoma, and was unsatisfactory for the local control of malignant melanoma. Because proton beams with superior depth dose distribution allow not only inhibition of damage to the surrounding normal tissue but also large fraction radiotherapy, proton beam therapy may become a promising method of therapy in skin malignant tumor. (N.K.)

  2. Opening of proton beam therapy in Japan

    International Nuclear Information System (INIS)

    Just after completion of the 12-GeV proton synchrotron complex at KEK in 1976, medical use of rapid-cycling 500-MeV Booster beams were investigated. Prof. Herman Suit of Harvard University recommended proton beam therapy, and soon it became clear that it was most suitable for Tsukuba. University of Tsukuba built and operated a medical research center with support of KEK. It included three activities, fast neutron therapy, proton radiography and proton therapy. It was showed clinically that the proton beam therapy is effective for deep-seated tumors such as hepatoma. (author)

  3. Holifield Radioactive Ion Beam Facility Status

    International Nuclear Information System (INIS)

    The Holifield Radioactive Ion Beam Facility (HRIBF) at Oak Ridge National Laboratory (ORNL) produces high-quality beams of short-lived radioactive isotopes for nuclear science research, and is currently unique worldwide in the ability to provide neutron-rich fission fragment beams post-accelerated to energies above the Coulomb barrier. HRIBF is undergoing a multi-phase upgrade. Phase I (completed 2005) was construction of the High Power Target Laboratory to provide the on-going Isotope Separator On-Line (ISOL) development program with a venue for testing new targets, ion sources, and radioactive ion beam (RIB) production techniques with high-power beams. Phase II, which is on schedule for completion in September 2009, is the Injector for Radioactive Ion Species 2 (IRIS2), a second RIB production station that will improve facility reliability and accommodate new ion sources, new RIB production targets, and some innovative RIB purification techniques, including laser applications. The Phase III goal is to substantially improve facility performance by replacing or supplementing the Oak Ridge Isochronous Cyclotron (ORIC) production accelerator with either a high-power 25-50 MeV electron accelerator or a high-current multi-beam commercial cyclotron. Either upgrade is applicable to R and D on isotope production for medical or other applications.

  4. OMEGA: a 24 beam uv irradiation facility

    International Nuclear Information System (INIS)

    We report the recent completion of the uv upconversion (351 nm) of all 24 beams of the OMEGA laser which provides a unique short wavelength symmetrical irradiation facility for direct drive laser fusion experiments. Details of the characterization of illumination uniformity and initial implosion experiments will be described

  5. Isobar Separators for Radioactive Ion Beam Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Garrett, J D; Wollnik, H

    1998-10-05

    A radioactive ion beam facility - in short a RIB facility - produces ions of short-lived nuclei and accelerates them to energies of 0.1...10 MeV per nucleon or even higher. In this process it is important that the resulting RIB beams are free from nuclei of neighboring isobars or of neighboring elements. This task requires the production and ionization of the nuclei of interest as well as separating them from all others with a high-mass resolving power and small-mass cross contaminations. When constructing such a facility it also is very important to find ways that allow the accelerated ions to be provided to different experiments at least quasi simultaneously.

  6. Health physics considerations at a neutron therapy facility cyclotron

    International Nuclear Information System (INIS)

    The U.C.L.A. Neutron Therapy Facility (NTF) is one of four such facilities in the United States currently involved in NCI sponsored trials of neutron therapy and reflects the present interest in the use of high energy neutron beams for treating certain types of human cancers. The NTF houses a CP-45 negative ion cyclotron which accelerates a 46 MeV proton beam for production of neutrons from a beryllium target. In addition to patient treatment, the NTF is involved in the production of positron emitting radioisotopes for diagnostic use in Positron Emission Tomography (PET). The activation of therapy treatment collimators, positron and neutron target systems, and a high and rapidly varying external radiation environment in a clinical setting have contributed to the need for a comprehensive radiation control program in which patient care is balanced with the maintenance of occupational exposures to ALARA levels

  7. Physical design of scanning gantry for proton therapy facility

    Energy Technology Data Exchange (ETDEWEB)

    Jiao, Y.; Satogata, T.; Guan, X-L.; Fang, S-X.; Wie, J.; Tang, J-Y.; Chen, Y.; Qui, J.; Shu, H.

    2010-03-01

    A proton therapy facility based on a linac injector and a slow cycling synchrotron is proposed. To achieve effective treatment of cancer, a scanning gantry is required. The flexible transmission of beam and high beam position accuracy are the most basic requirements for a gantry. The designed gantry optics and scanning system are presented. Great efforts are put into studying the sensitivity of the beam position in the isocenter to the element misalignments. It shows that quadrupole shift makes the largest contribution and special attention should be paid to it.

  8. Advanced Electron Beam Ion Sources (EBIS) for 2-nd generation carbon radiotherapy facilities

    International Nuclear Information System (INIS)

    In this work we analyze how advanced Electron Beam Ion Sources (EBIS) can facilitate the progress of carbon therapy facilities. We will demonstrate that advanced ion sources enable operation of 2-nd generation ion beam therapy (IBT) accelerators. These new accelerator concepts with designs dedicated to IBT provide beams better suited for therapy and, are more cost efficient than contemporary IBT facilities. We will give a sort overview of the existing new IBT concepts and focus on those where ion source technology is the limiting factor. We will analyse whether this limitation can be overcome in the near future thanks to ongoing EBIS development

  9. Advanced Electron Beam Ion Sources (EBIS) for 2-nd generation carbon radiotherapy facilities

    Science.gov (United States)

    Shornikov, A.; Wenander, F.

    2016-04-01

    In this work we analyze how advanced Electron Beam Ion Sources (EBIS) can facilitate the progress of carbon therapy facilities. We will demonstrate that advanced ion sources enable operation of 2-nd generation ion beam therapy (IBT) accelerators. These new accelerator concepts with designs dedicated to IBT provide beams better suited for therapy and, are more cost efficient than contemporary IBT facilities. We will give a sort overview of the existing new IBT concepts and focus on those where ion source technology is the limiting factor. We will analyse whether this limitation can be overcome in the near future thanks to ongoing EBIS development.

  10. Beam monitoring in radiotherapy and hadron-therapy

    International Nuclear Information System (INIS)

    Radiotherapy techniques have evolved over the past twenty years. For photon beams, the development of tools such as multi leaf collimators, machines such as Cyberknife or tomo-therapy, have improved the conformation of treatments to the tumor volume and lowered maximum dose to healthy tissue. In another register, the use of proton-therapy is expanding in all countries and the development of carbon ions beams for hadron-therapy is also increasing. If techniques improve, the control requirements for the monitoring of the dose administered to patients are always the same. This document presents, first, the ins and outs of the different techniques of external beam radiotherapy: photon treatments, protons and hadrons. Starting from the basis of clinical requirements, it sets the variables to be measured in order to ensure the quality of treatment for the different considered modalities. It then describes some implementations, based on precise and rigorous specifications, for the monitoring and measurement of beams delivered by external beam radiotherapy equipments. Two instrumental techniques are particularly highlighted, plastic scintillators dosimetry for the control of megavoltage photon beams and ionization chamber dosimetry applied to proton-therapy or radiobiology experiments conducted at the GANIL facility. Analyzes and perspectives, based on the recent developments of treatment techniques, are delivered in conclusion and can serve as guide for future instrumental developments. (author)

  11. A radioactive ion beam facility using photofission

    CERN Document Server

    Diamond, W T

    1999-01-01

    Use of a high-power electron linac as the driver accelerator for a Radioactive Ion Beam (RIB) facility is proposed. An electron beam of 30 MeV and 100 kW can produce nearly 5x10 sup 1 sup 3 fissions/s from an optimized sup 2 sup 3 sup 5 U target and about 60% of this from a natural uranium target. An electron beam can be readily transmitted through a thin window at the exit of the accelerator vacuum system and transported a short distance through air to a water-cooled Bremsstrahlung-production target. The Bremsstrahlung radiation can, in turn, be transported through air to the isotope-production target. This separates the accelerator vacuum system, the Bremsstrahlung target and the isotope-production target, reducing remote handling problems. The electron beam can be scanned over a large target area to reduce the power density on both the Bremsstrahlung and isotope-production targets. These features address one of the most pressing technological challenges of a high-power RIB facility, namely the production o...

  12. Beam control and Dosimetry in Proton Therapy

    International Nuclear Information System (INIS)

    This thesis deals with beam control devices for scanned proton beams. The IBA society (Ion Beam Applications) has developed a new dynamic beam delivery system called Pencil Beam Scanning. IBA needed a monitor unit to equip its proton beam lines dedicated to the PBS system and called upon the medical applications group of the Laboratoire de Physique Corpusculaire de Caen. In 2008, this group realized, in collaboration with IBA, an ionization chamber monitor IC2/3 for the IBA dedicated PBS nozzle. This device verifies the agreement between planned and delivered particular fluence. The first part of this thesis focused on the characterization of this monitor unit. Proton beams of different clinical energies, positions and dose rates were used to check the specifications requested by IBA. After the introduction about the Proton Therapy, the validation step of IC2/3 is exposed. Information provided by IC2/3 makes it possible beam control in terms of fluence but does not ensure quality control in terms of spatial dose distribution. The second part of the work was devoted to the conception of a beam control device for scanned proton beams. Called Compass PT, it will allow a reconstruction of the spatial dose distribution delivered to the patient. The specifications definition and the conception studies are presented in this thesis. All this work has led to recommendations for the realization of this device and new research prospects. (author)

  13. Dose reporting in ion beam therapy. Proceedings of a meeting

    International Nuclear Information System (INIS)

    Following the pioneering work in Berkeley, USA, ion beam therapy for cancer treatment is at present offered in Chiba and Hyogo in Japan, and Darmstadt in Germany. Other facilities are coming close to completion or are at various stages of planning in Europe and Japan. In all these facilities, carbon ions have been selected as the ions of choice, at least in the first phase. Taking into account this fast development, the complicated technical and radiobiological research issues involved, and the hope it raises for some types of cancer patients, the IAEA and the International Commission on Radiation Units and measurements (ICRU) jointly sponsored a technical meeting held in Vienna, 23-24 June 2004. That first meeting was orientated mainly towards radiobiology: the relative biological effectiveness (RBE) of carbon ions versus photons, and related issues. One of the main differences between ion beam therapy and other modern radiotherapy techniques (such as proton beam therapy or intensity modulated radiation therapy) is related to radiobiology and in particular the increased RBE of carbon ions compared to both protons and photons (i.e., high linear energy transfer (LET) versus low LET radiation). Another important issue for international agencies and commissions, such as the IAEA and the ICRU, is a worldwide agreement and harmonisation for reporting the treatments. In order to evaluate the merits of ion beam therapy, it is essential that the treatments be reported in a similar/comparable way in all centres so that the clinical reports and protocols can be understood and interpreted without ambiguity by the radiation therapy community in general. For the last few decades, the ICRU has published several reports containing recommendations on how to report external photon beam or electron beam therapy, and brachytherapy. A report on proton beam therapy, jointly prepared by the ICRU and the IAEA, is now completed and is being published in the ICRU series. In line with this

  14. Principles and practice of proton beam therapy

    CERN Document Server

    Das, Indra J

    2015-01-01

    Commissioned by The American Association of Physicists in Medicine (AAPM) for their June 2015 Summer School, this is the first AAPM monograph printed in full color. Proton therapy has been used in radiation therapy for over 70 years, but within the last decade its use in clinics has grown exponentially. This book fills in the proton therapy gap by focusing on the physics of proton therapy, including beam production, proton interactions, biology, dosimetry, treatment planning, quality assurance, commissioning, motion management, and uncertainties. Chapters are written by the world's leading medical physicists who work at the pioneering proton treatment centers around the globe. They share their understandings after years of experience treating thousands of patients. Case studies involving specific cancer treatments show that there is some art to proton therapy as well as state-of-the-art science. Even though the focus lies on proton therapy, the content provided is also valuable to heavy charged particle th...

  15. Radioactive Ion Beam Development at the Holifield Radioactive Ion Beam Facility

    CERN Document Server

    Stracener, Dan; Beene, James R; Bilheux, Hassina Z; Bilheux, Jean-Christophe; Blackmon, Jeff C; Carter, Ken; Dowling, Darryl; Juras, Raymond; Kawai, Yoko; Kronenberg, Andreas; Liu, Yuan; Meigs, Martha; Müller, Paul; Spejewski, Eugene H; Tatum, A

    2005-01-01

    Radioactive beams are produced at the Holifield Radioactive Ion Beam Facility (HRIBF) at Oak Ridge National Laboratory using the Isotope Separator On-Line (ISOL) technique. Radioactive nuclei are produced in a thick target via irradiation with energetic light ions (protons, deuterons, helium isotopes) and then post-accelerated to a few MeV/nucleon for use in nuclear physics experiments. An overview of radioactive beam development at the HRIBF will be presented, including ion source development, improvements in the ISOL production targets, and a description of techniques to improve the quality (intensity and purity) of the beams. Facilities for radioactive ion beam development include two ion source test facilities, a target/ion source preparation and quality assurance facility, and an in-beam test facility where low intensity production beams are used. A new test facility, the High Power Target Laboratory, will be available later this year. At this facility, high intensity production beams will be available t...

  16. Ion beam therapy fundamentals, technology, clinical applications

    CERN Document Server

    2012-01-01

    The book provides a detailed, up-to-date account of the basics, the technology, and the clinical use of ion beams for radiation therapy. Theoretical background, technical components, and patient treatment schemes are delineated by the leading experts that helped to develop this field from a research niche to its current highly sophisticated and powerful clinical treatment level used to the benefit of cancer patients worldwide. Rather than being a side-by-side collection of articles, this book consists of related chapters. It is a common achievement by 76 experts from around the world. Their expertise reflects the diversity of the field with radiation therapy, medical and accelerator physics, radiobiology, computer science, engineering, and health economics. The book addresses a similarly broad audience ranging from professionals that need to know more about this novel treatment modality or consider to enter the field of ion beam therapy as a researcher. However, it is also written for the interested public an...

  17. Microdosimetric investigations at the fast neutron therapy facility at Fermilab

    International Nuclear Information System (INIS)

    Microdosimetry was used to investigate three issues at the neutron therapy facility (NTF) at Fermilab. Firstly, the conversion factor from absorbed dose in A-150 tissue equivalent plastic to absorbed dose in ICRU tissue was determined. For this, the effective neutron kerma factor ratios, i.e., oxygen tissue equivalent plastic and carbon to A-150 tissue equivalent plastic, were measured in the neutron beam. An A-150 tissue equivalent plastic to ICRU tissue absorbed dose conversion factor of 0.92 ± 0.04 was determined. Secondly, variations in the radiobiological effectiveness (RBE) in the beam were mapped by determining variations in two related quantities, e* and R, with field size and depth in tissue. Maximal variation in e* and R of 9% and 15% respectively were determined. Lastly, the feasibility of utilizing the boron neutron capture reaction on boron-10 to selectively enhance the tumor dose in the NTF beam was investigated

  18. Microdosimetric investigations at the fast neutron therapy facility at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Langen, K.M.

    1997-12-01

    Microdosimetry was used to investigate three issues at the neutron therapy facility (NTF) at Fermilab. Firstly, the conversion factor from absorbed dose in A-150 tissue equivalent plastic to absorbed dose in ICRU tissue was determined. For this, the effective neutron kerma factor ratios, i.e., oxygen tissue equivalent plastic and carbon to A-150 tissue equivalent plastic, were measured in the neutron beam. An A-150 tissue equivalent plastic to ICRU tissue absorbed dose conversion factor of 0.92 {+-} 0.04 was determined. Secondly, variations in the radiobiological effectiveness (RBE) in the beam were mapped by determining variations in two related quantities, e{sup *} and R, with field size and depth in tissue. Maximal variation in e{sup *} and R of 9% and 15% respectively were determined. Lastly, the feasibility of utilizing the boron neutron capture reaction on boron-10 to selectively enhance the tumor dose in the NTF beam was investigated.

  19. Particle beam therapy for cancer. A radiobiological perspective

    International Nuclear Information System (INIS)

    As for the particle beam therapy, there is to theoretical evidence by radiobiology. The particle beam therapy becomes high precision by development of the medicine engineering. We demonstrated the past contribution for the particle beam therapy and recent knowledge about radiobiological phenomenon such as (1) DNA damage and the repair, (2) cell killing effect, (3) metastasis, and (4) therapeutic gain. Finally, we discuss it about the radiobiological perspective for the particle beam therapy. (author)

  20. Radioactive nuclear beams of COMBAS facility

    Science.gov (United States)

    Artukh, A. G.; Klygin, S. A.; Kononenko, G. A.; Kyslukha, D. A.; Lukyanov, S. M.; Mikhailova, T. I.; Penionzhkevich, Yu. E.; Oganessian, Yu. Ts.; Sereda, Yu. M.; Vorontsov, A. N.; Erdemchimeg, B.

    2016-01-01

    The basic ion-optical characteristics of the luminosity and the high-resolution of kinematic separator COMBAS realized for the first time on the strong focusing principle are presented. The developed facility allows to separate the high-intensity secondary radioactive beams in a wide range of mass numbers A and atomic numbers Z which are produced in heavy ion reactions in the energy range of 20 ≤ E ≤ 100 MeV/A (Fermi energy domain). Two distinct detector systems such as realized Si strip detector telescope and the promising development of the three dimension time-projection chamber are discussed. Program of the investigations of nuclear reaction mechanisms at intermediate energies of 20-100 MeV/A, measurement of the radii of unstable nuclei, study of the cluster structure of light nuclei near the nuclear drip-line and search of 26,28O resonances in exchange reactions is proposed. The upgrading of experimental facility by the integration of COMBAS separator with the Ion Catcher is discussed.

  1. New ISOL-based radioactive nuclear beam facility at INS

    International Nuclear Information System (INIS)

    An ISOL-based radioactive nuclear beam facility is just about to come into operation at INS. The present status of the INS radioactive nuclear beam project is reported. The capability of the facility and possible experiments are also discussed, including research programs of nuclear physics and nuclear astrophysics. (orig.)

  2. Dosimetry measurements at the fast neutron therapy facility in Seattle

    International Nuclear Information System (INIS)

    The fast neutron therapy facility at the University of Washington has been in routine clinical use for 25 years. 50.5 MeV protons produce neutrons in a beryllium target mounted on an isocentric gantry. Beam shaping is accomplished with a 40-leaf collimator. Dosimetry measurements for treatment planning and calibration are performed with tissue equivalent ion chambers. A layered phantom of alternating Solid Water and Plastic Water slabs has been developed for rapid dose verification measurements. The neutron field in the room has been used for radiation testing of electronic components.

  3. Repeated proton beam therapy for hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Purpose: To retrospectively evaluate the safety and effectiveness of repeated proton beam therapy for newly developed or recurrent hepatocellular carcinoma (HCC). Methods and Materials: From June 1989 through July 2000, 225 patients with HCC underwent their first course of proton beam therapy at University of Tsukuba. Of them, 27 with 68 lesions who had undergone two or more courses were retrospectively reviewed in this study. Median interval between the first and second course was 24.5 months (range 3.3-79.8 months). Median total dose of 72 Gy in 16 fractions and 66 Gy in 16 fractions were given for the first course and the rest of the courses, respectively. Results: The 5-year survival rate and median survival period from the beginning of the first course for the 27 patients were 55.6% and 62.2 months, respectively. Five-year local control rate for the 68 lesions was 87.8%. Of the patients, 1 with Child-Pugh class B and another with class C before the last course suffered from acute hepatic failure. Conclusions: Repeated proton beam therapy for HCC is safe when the patient has a target in the peripheral region of the liver and liver function is Child-Pugh class A

  4. Synchrotron light beam and a synchrotron light experiment facility

    International Nuclear Information System (INIS)

    In the National Laboratory for High Energy Physics, about two years ago, the requirements of synchrotron light beam in respective measuring instruments were discussed. Then, also the arrangement (lattice) of a storage ring, the nature of synchrotron light beam, a synchrotron light experiment facility and the arrangement of the beam lines were studied. During the period of two years since then, due to the changes in the circumstances, the design of the lattice was altered. Accordingly, the arrangement of the beam lines and of measuring instruments were largely changed. At this point, the results of discussions in various meetings are described, though they may still be subject to future changes, with due consideration to beam, environment and beam lines required for the design of the measuring instruments: (1) storage ring and synchrotron light beam, (2) requirements on small beam size and beam stability, (3) a synchrotron light experiment facility. (J.P.N.)

  5. A standardized method for beam design in neutron capture therapy

    International Nuclear Information System (INIS)

    A desirable end point for a given beam design for Neutron Capture Therapy (NCT) should be quantitative description of tumour control probability and normal tissue damage. Achieving this goal will ultimately rely on data from NCT human clinical trials. Traditional descriptions of beam designs have used a variety of assessment methods to quantify proposed or installed beam designs. These methods include measurement and calculation of open-quotes free fieldclose quotes parameters, such as neutron and gamma flux intensities and energy spectra, and figures-of-merit in tissue equivalent phantoms. The authors propose here a standardized method for beam design in NCT. This method would allow all proposed and existing NCT beam facilities to be compared equally. The traditional approach to determining a quantitative description of tumour control probability and normal tissue damage in NCT research may be described by the following path: Beam design → dosimetry → macroscopic effects → microscopic effects. Methods exist that allow neutron and gamma fluxes and energy dependence to be calculated and measured to good accuracy. By using this information and intermediate dosimetric quantities such as kerma factors for neutrons and gammas, macroscopic effect (absorbed dose) in geometries of tissue or tissue-equivalent materials can be calculated. After this stage, for NCT the data begins to become more sparse and in some areas ambiguous. Uncertainties in the Relative Biological Effectiveness (RBE) of some NCT dose components means that beam designs based on assumptions considered valid a few years ago may have to be reassessed. A standard method is therefore useful for comparing different NCT facilities

  6. Thin silicon strip detectors for beam monitoring in Micro-beam Radiation Therapy

    CERN Document Server

    Povoli, Marco; Bravin, Alberto; Cornelius, Iwan; Bräuer-Krisch, Elke; Fournier, Pauline; Hansen, Thor-Erik; Kok, Angela; Lerch, Michael; Monakhov, Edouard; Morse, John; Petasecca, Marco; Requardt, Herwig; Rosenfeld, Anatoly; Röhrich, Dieter; Sandaker, Heidi; Salomé, Murielle; Stugu, Bjarne

    2015-01-01

    Microbeam Radiation Therapy (MRT) is an emerging cancer treatment that is currently being developed at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France. This technique uses a highly collimated and fractionated X-ray beam array with extremely high dose rate and very small divergence, to benefit from the dose-volume effect, thus sparing healthy tissue. In case of any beam anomalies and system malfunctions, special safety measures must be installed, such as an emergency safety shutter that requires continuous monitoring of the beam intensity profile. Within the 3DMiMic project, a novel silicon strip detector that can tackle the special features of MRT, such as the extremely high spatial resolution and dose rate, has been developed to be part of the safety shutter system. The first prototypes have been successfully fabricated, and experiments aimed to demonstrate their suitability for this unique application have been performed. Design, fabrication and the experimental results as well as any...

  7. Microdosimetric investigations at the Fast Neutron Therapy Facility at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Langen, K.M.

    1997-12-31

    Microdosimetry was used to investigate three issues at the neutron therapy facility (NTF) at Fermilab. Firstly, the conversion factor from absorbed dose in A-150 tissue equivalent plastic to absorbed dose in ICRU tissue was determined. For this, the effective neutron kerma factor ratios, i.e. oxygen tissue equivalent plastic and carbon to A-150 tissue equivalent plastic, were measured in the neutron beam. An A-150 tissue equivalent plastic to ICRU tissue absorbed dose conversion factor of 0.92 {+-} 0.04 determined. Secondly, variations in the radiobiological effectiveness (RBE) in the beam were mapped by determining variations in two related quantities, e{sup *} and R, with field size and depth in tissue. Maximal variation in e{sup *} and R of 9% and 15% respectively were determined. Lastly, the feasibility of utilizing the boron neutron capture reaction on boron-10 to selectively enhance the tumor dose in the NTF beam was investigated. In the unmodified beam, a negligible enhancement for a 50 ppm boron loading was measured. To boost the boron dose enhancement to 3% it was necessary to change the primary proton energy from 66 MeV and to filter the beam by 90 mm of tungsten.

  8. Characterizing and Controlling Beam Losses at the LANSCE Facility

    Energy Technology Data Exchange (ETDEWEB)

    Rybarcyk, Lawrence J. [Los Alamos National Laboratory

    2012-09-12

    The Los Alamos Neutron Science Center (LANSCE) currently provides 100-MeV H{sup +} and 800-MeV H{sup -} beams to several user facilities that have distinct beam requirements, e.g. intensity, micropulse pattern, duty factor, etc. Minimizing beam loss is critical to achieving good performance and reliable operation, but can be challenging in the context of simultaneous multi-beam delivery. This presentation will discuss various aspects related to the observation, characterization and minimization of beam loss associated with normal production beam operations in the linac.

  9. Holifield Radioactive Ion Beam Facility Development and Status

    CERN Document Server

    Tatum, Alan

    2005-01-01

    The Holifield Radioactive Ion Beam Facility (HRIBF) is a national user facility dedicated to nuclear structure, reactions, and nuclear astrophysics research with radioactive ion beams (RIBs) using the isotope separator on-line (ISOL) technique. An integrated strategic plan for physics, experimental systems, and RIB production facilities have been developed and implementation of the plan is under way. Specific research objectives are defined for studying the nature of nucleonic matter, the origin of elements, solar physics, and synthesis of heavy elements. Experimental systems upgrade plans include new detector arrays and beam lines, and expansion and upgrade of existing devices. A multifaceted facility expansion plan includes a $4.75M High Power Target Laboratory (HPTL), presently under construction, to provide a facility for testing new target materials, target geometries, ion sources, and beam preparation techniques. Additional planned upgrades include a second RIB production system (IRIS2), an external axi...

  10. A button - type beam position monitor design for TARLA facility

    Science.gov (United States)

    Gündoǧan, M. Tural; Kaya, ć.; Yavaş, Ö.

    2016-03-01

    Turkish Accelerator and Radiation Laboratory in Ankara (TARLA) facility is proposed as an IR FEL and Bremsstrahlung facility as the first facility of Turkish Accelerator Center (TAC). TARLA is essentially proposed to generate oscillator mode FEL in 3-250 microns wavelengths range, will consist of normal conducting injector system with 250 keV beam energy, two superconducting RF accelerating modules in order to accelerate the beam 15-40 MeV. The TARLA facility is expected to provide two modes, Continuous wave (CW) and pulsed mode. Longitudinal electron bunch length will be changed between 1 and 10 ps. The bunch charge will be limited by 77pC. The design of the Button-type Beam Position Monitor for TARLA IR FEL is studied to operate in 1.3 GHz. Mechanical antenna design and simulations are completed considering electron beam parameters of TARLA. Ansoft HFSS and CST Particle Studio is used to compare with results of simulations.

  11. A Monte Carlo-based treatment-planning tool for ion beam therapy

    CERN Document Server

    Böhlen, T T; Dosanjh, M; Ferrari, A; Haberer, T; Parodi, K; Patera, V; Mairan, A

    2013-01-01

    Ion beam therapy, as an emerging radiation therapy modality, requires continuous efforts to develop and improve tools for patient treatment planning (TP) and research applications. Dose and fluence computation algorithms using the Monte Carlo (MC) technique have served for decades as reference tools for accurate dose computations for radiotherapy. In this work, a novel MC-based treatment-planning (MCTP) tool for ion beam therapy using the pencil beam scanning technique is presented. It allows single-field and simultaneous multiple-fields optimization for realistic patient treatment conditions and for dosimetric quality assurance for irradiation conditions at state-of-the-art ion beam therapy facilities. It employs iterative procedures that allow for the optimization of absorbed dose and relative biological effectiveness (RBE)-weighted dose using radiobiological input tables generated by external RBE models. Using a re-implementation of the local effect model (LEM), theMCTP tool is able to perform TP studies u...

  12. In-beam activation analysis facility at MLZ, Garching

    Energy Technology Data Exchange (ETDEWEB)

    Révay, Zs., E-mail: zsolt.revay@frm2.tum.de [Heinz Maier-Leibniz Zentrum (MLZ), Technische Universität München, 85748 Garching (Germany); Kudějová, P.; Kleszcz, K.; Söllradl, S. [Heinz Maier-Leibniz Zentrum (MLZ), Technische Universität München, 85748 Garching (Germany); Genreith, Christoph [Heinz Maier-Leibniz Zentrum (MLZ), Technische Universität München, 85748 Garching (Germany); Institute of Energy and Climate Research, IEK-6: Nuclear Waste and Reactor Safety Fuel Cycle, Forschungszentrum Jülich GmbH in der Helmholtz-Gemeinschaft, 52428 Jülich (Germany)

    2015-11-01

    The reconstruction of the prompt gamma activation analysis facility and the construction of the new low-background counting chamber at MLZ, Garching is presented. The improvement of the shielding and its effect on the radiation background is shown. The setting up and the fine-tuning of the electronics and their characterization are also discussed. The upgraded facility has been demonstrated to be applicable for both PGAA and neutron activation analysis using in-beam activation and decay counting in the low-background counting chamber. - Highlights: • Radiation background at the PGAA facility was efficiently reduced. • In-beam irradiation facility in the strongest neutron beam. • The best signal-to-background ratio at a PGAA facility was achieved.

  13. Dosimetry auditing procedure with alanine dosimeters for light ion beam therapy

    DEFF Research Database (Denmark)

    Ableitinger, Alexander; Vatnitsky, Stanislav; Herrmann, Rochus;

    2013-01-01

    Background and purpose In the next few years the number of facilities providing ion beam therapy with scanning beams will increase. An auditing process based on an end-to-end test (including CT imaging, planning and dose delivery) could help new ion therapy centres to validate their entire logistic...... chain of radiation delivery. An end-to-end procedure was designed and tested in both scanned proton and carbon ion beams, which may also serve as a dosimetric credentialing procedure for clinical trials in the future. The developed procedure is focused only on physical dose delivery and the validation...... of about 3%. Conclusions Alanine dosimeters are suitable detectors for dosimetry audits in ion beam therapy and the presented end-to-end test is feasible. If further studies show similar results, this dosimetric audit could be implemented as a credentialing procedure for clinical proton and carbon beam...

  14. Overview of Light-Ion Beam Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Chu, William T.

    2006-03-16

    treatment volume compared to those in conventional (photon) treatments. Wilson wrote his personal account of this pioneering work in 1997. In 1954 Cornelius Tobias and John Lawrence at the Radiation Laboratory (former E.O. Lawrence Berkeley National Laboratory) of the University of California, Berkeley performed the first therapeutic exposure of human patients to hadron (deuteron and helium ion) beams at the 184-Inch Synchrocyclotron. By 1984, or 30 years after the first proton treatment at Berkeley, programs of proton radiation treatments had opened at: University of Uppsala, Sweden, 1957; the Massachusetts General Hospital-Harvard Cyclotron Laboratory (MGH/HCL), USA, 1961; Dubna (1967), Moscow (1969) and St Petersburg (1975) in Russia; Chiba (1979) and Tsukuba (1983) in Japan; and Villigen, Switzerland, 1984. These centers used the accelerators originally constructed for nuclear physics research. The experience at these centers has confirmed the efficacy of protons and light ions in increasing the tumor dose relative to normal tissue dose, with significant improvements in local control and patient survival for several tumor sites. M.R. Raju reviewed the early clinical studies. In 1990, the Loma Linda University Medical Center in California heralded in the age of dedicated medical accelerators when it commissioned its proton therapy facility with a 250-MeV synchrotron. Since then there has been a relatively rapid increase in the number of hospital-based proton treatment centers around the world, and by 2006 there are more than a dozen commercially-built facilities in use, five new facilities under construction, and more in planning stages. In the 1950s larger synchrotrons were built in the GeV region at Brookhaven (3-GeV Cosmotron) and at Berkeley (6-GeV Bevatron), and today most of the world's largest accelerators are synchrotrons. With advances in accelerator design in the early 1970s, synchrotrons at Berkeley and Princeton accelerated ions with atomic numbers

  15. Overview of Light-Ion Beam Therapy

    International Nuclear Information System (INIS)

    compared to those in conventional (photon) treatments. Wilson wrote his personal account of this pioneering work in 1997. In 1954 Cornelius Tobias and John Lawrence at the Radiation Laboratory (former E.O. Lawrence Berkeley National Laboratory) of the University of California, Berkeley performed the first therapeutic exposure of human patients to hadron (deuteron and helium ion) beams at the 184-Inch Synchrocyclotron. By 1984, or 30 years after the first proton treatment at Berkeley, programs of proton radiation treatments had opened at: University of Uppsala, Sweden, 1957; the Massachusetts General Hospital-Harvard Cyclotron Laboratory (MGH/HCL), USA, 1961; Dubna (1967), Moscow (1969) and St Petersburg (1975) in Russia; Chiba (1979) and Tsukuba (1983) in Japan; and Villigen, Switzerland, 1984. These centers used the accelerators originally constructed for nuclear physics research. The experience at these centers has confirmed the efficacy of protons and light ions in increasing the tumor dose relative to normal tissue dose, with significant improvements in local control and patient survival for several tumor sites. M.R. Raju reviewed the early clinical studies. In 1990, the Loma Linda University Medical Center in California heralded in the age of dedicated medical accelerators when it commissioned its proton therapy facility with a 250-MeV synchrotron. Since then there has been a relatively rapid increase in the number of hospital-based proton treatment centers around the world, and by 2006 there are more than a dozen commercially-built facilities in use, five new facilities under construction, and more in planning stages. In the 1950s larger synchrotrons were built in the GeV region at Brookhaven (3-GeV Cosmotron) and at Berkeley (6-GeV Bevatron), and today most of the world's largest accelerators are synchrotrons. With advances in accelerator design in the early 1970s, synchrotrons at Berkeley and Princeton accelerated ions with atomic numbers between 6 and 18, at

  16. Extraction and beam transfer for the SHiP facility

    CERN Document Server

    Goddard, Brennan; Borburgh, Jan; Balhan, Bruno; Le Godec, Gilles; Zerlauth, Markus; Tommasini, Davide; Kain, Verena; Cornelis, Karel; Wenninger, Jorg; Jensen, Lars; Todd, Benjamin; Bauche, Jeremie; Puccio, Bruno

    2015-01-01

    This document summarises the key feasibility issues associated with the SPS extraction and beam transfer systems required for the SHiP facility. It describes the expected performance limits of the electrostatic septa, the expected beam losses during extraction and consequences, the design of the new beamline geometry and equipment systems and the expected extracted spill structure.

  17. The FLUKA code for application of Monte Carlo methods to promote high precision ion beam therapy

    CERN Document Server

    Parodi, K; Cerutti, F; Ferrari, A; Mairani, A; Paganetti, H; Sommerer, F

    2010-01-01

    Monte Carlo (MC) methods are increasingly being utilized to support several aspects of commissioning and clinical operation of ion beam therapy facilities. In this contribution two emerging areas of MC applications are outlined. The value of MC modeling to promote accurate treatment planning is addressed via examples of application of the FLUKA code to proton and carbon ion therapy at the Heidelberg Ion Beam Therapy Center in Heidelberg, Germany, and at the Proton Therapy Center of Massachusetts General Hospital (MGH) Boston, USA. These include generation of basic data for input into the treatment planning system (TPS) and validation of the TPS analytical pencil-beam dose computations. Moreover, we review the implementation of PET/CT (Positron-Emission-Tomography / Computed- Tomography) imaging for in-vivo verification of proton therapy at MGH. Here, MC is used to calculate irradiation-induced positron-emitter production in tissue for comparison with the +-activity measurement in order to infer indirect infor...

  18. National facility for neutron beam research in India

    International Nuclear Information System (INIS)

    A national facility for neutron beam research is operated at the research reactor Dhruva in BARC. It includes single-crystal and powder diffractometers, a polarization analysis spectrometer, inelastic and quasi-elastic scattering spectrometers in the reactor hall, and smallangle scattering instruments and a polarized neutron reflectometer in the neutron-guide laboratory. The National facility is utilized in collaboration with various universities and other institutions. The talk will present our facilities and discuss examples of recent work.

  19. Synthetic methods for beam to beam power balancing capability of large laser facilities

    International Nuclear Information System (INIS)

    To account for output power balancing capability of large laser facilities, a synthetic method with beam to beam root-mean-square is presented. Firstly, a conversion process for the facilities from original data of beam powers to regular data is given. The regular data contribute to the normal distribution approximately, and then a corresponding simple method of root-mean-square for beam to beam power balancing capability is given.Secondly, based on theory of total control charts and cause-selecting control charts, control charts with root-mean-square are established which show short-term variety of power balancing capability of the facilities. Mean rate of failure occurrence is also defined and used to describe long-term trend of global balancing capabilities of the facilities. Finally, advantages of the intuitive and efficient diagnosis for synthetic methods are illustrated by analysis of experimental data. (authors)

  20. A beam expander facility for studying x-ray optics

    DEFF Research Database (Denmark)

    Christensen, Finn Erland; Hornstrup, Allan; Frederiksen, P.; Nilsson, C.; Grundsøe, Peter; Ørup, P.; Jacobsen, E.; Schnopper, H. W.; Lewis, R.; Hall, C.

    1992-01-01

    The detailed study of the performance of full scale x-ray optics often requires the illumination of large areas. This paper describes a beam expander facility at the Daresbury Synchrotron Radiation Facility. It combines monochromatization and beam expansion in one dimension. The beam expansion is...... obtained from an extremely asymmetric reflection in a large single crystal of Si. An expansion of a factor of 50 was obtained in one dimension. The expanded beam of ~85 mm is limited only by the crystal size. The facility is installed in a 12-m-long hutch. A specific application, in which a high throughput...... x-ray telescope will be studied, is described in detail. Review of Scientific Instruments is copyrighted by The American Institute of Physics....

  1. Concept for an advanced exotic beam facility based on ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Rehm, K.E.; Ahmad, I.; Back, B.B. [and others

    1995-08-01

    The acceleration of beams of unstable nuclei has opened up new research frontiers. Experiments at existing accelerators, and particularly at the first generation of radioactive ion beam facilities, have demonstrated convincingly that unique information becomes accessible. Critical cross sections for astrophysical processes that were impossible to obtain previously, qualitatively new and unexpected nuclear structure effects in nuclei far from stability, completely new approaches to studies of nuclear decays, reactions and structure, all have triggered much excitement for this new dimension in nuclear research. To explore this new dimension, an extension of present technical capabilities and facilities is needed. This need and its scientific basis were discussed in various workshops and symposia and in the Isospin Laboratory (ISL) White Paper. A report by the European community was published recently on prospects of radioactive beam facilities in Europe, and some next-generation projects for such facilities are starting in both Europe and Japan.

  2. Beam Characterization at the Neutron Radiography Facility

    Energy Technology Data Exchange (ETDEWEB)

    Sarah Morgan; Jeffrey King

    2013-01-01

    The quality of a neutron imaging beam directly impacts the quality of radiographic images produced using that beam. Fully characterizing a neutron beam, including determination of the beam’s effective length-to-diameter ratio, neutron flux profile, energy spectrum, image quality, and beam divergence, is vital for producing quality radiographic images. This project characterized the east neutron imaging beamline at the Idaho National Laboratory Neutron Radiography Reactor (NRAD). The experiments which measured the beam’s effective length-to-diameter ratio and image quality are based on American Society for Testing and Materials (ASTM) standards. An analysis of the image produced by a calibrated phantom measured the beam divergence. The energy spectrum measurements consist of a series of foil irradiations using a selection of activation foils, compared to the results produced by a Monte Carlo n-Particle (MCNP) model of the beamline. Improvement of the existing NRAD MCNP beamline model includes validation of the model’s energy spectrum and the development of enhanced image simulation methods. The image simulation methods predict the radiographic image of an object based on the foil reaction rate data obtained by placing a model of the object in front of the image plane in an MCNP beamline model.

  3. E-beam facility for collaborative research

    International Nuclear Information System (INIS)

    An indigenously developed Microtron facility at Mangalore University is being used for variety of research activities in interdisciplinary areas of science and technology. The unique facility with 8 MeV electrons, intense Bremsstrahlung photons and neutrons of moderate flux facilitates a number of co-ordinated R and D programs in collaboration with universities and national laboratories. A bird's eye view of all these activities along with a few sample results is presented in this paper. (author)

  4. Overview of linac applications at future radioactive beam facilities

    International Nuclear Information System (INIS)

    There is considerable interest worldwide in the research which could be done at a next generation, advanced radioactive beam facility. To generate high quality, intense beams of accelerated radionuclides via the open-quotes isotope separator on-lineclose quotes (ISOL) method requires two major accelerator components: a high power (100 kW) driver device to produce radionuclides in a production target/ion source complex, and a secondary beam accelerator to produce beams of radioactive ions up to energies on the order of 10 MeV per nucleon over a broad mass range. In reviewing the technological challenges of such a facility, several types of modem linear accelerators appear well suited. This paper reviews the properties of the linacs currently under construction and those proposed for future facilities for use either as the driver device or the radioactive beam post-accelerator. Other choices of accelerators, such as cyclotrons, for either the driver or secondary beam devices of a radioactive beam complex will also be compared. Issues to be addressed for the production accelerator include the choice of ion beam types to be used for cost-effective production of radionuclides. For the post-accelerator the choice of ion source technology is critical and dictates the charge-to-mass requirements at the injection stage

  5. CERN AWAKE Facility Readiness for First Beam

    CERN Document Server

    Bracco, Chiara; Butterworth, Andrew; Damerau, Heiko; Döbert, Steffen; Fedosseev, Valentin; Feldbaumer, Eduard; Gschwendtner, Edda; Höfle, Wolfgang; Pardons, Ans; Shaposhnikova, Elena; Vincke, Helmut

    2016-01-01

    The AWAKE project at CERN was approved in August 2013 and since then a big effort was made to be able to probe the acceleration of electrons before the "2019-2020 Long Shutdown". The next steps in this challenging schedule will be a dry run of all the beam line systems, at the end of the HW commissioning in June 2016, and the first proton beam sent to the plasma cell one month later. The current status of the project is presented together with an outlook over the foreseen works for operation with electrons in 2018.

  6. Monte Carlo Simulations of New 2D Ripple Filters for Particle Therapy Facilities

    DEFF Research Database (Denmark)

    Ringbæk, Toke Printz; Weber, Uli; Petersen, Jørgen B.B.;

    2014-01-01

    Introduction: At particle therapy facilities with pencil beam scanning, the implementation of a Ripple Filter (RiFi) broadens the Bragg peak (BP), which leads to fewer energy steps from the accelerator required to obtain a homogeneous dose coverage of the planned target volume (PTV). At the...

  7. External beam radiation therapy for prostate cancer

    International Nuclear Information System (INIS)

    Purpose/Objectives: The intent of this course is to review the issues involved in the management of non-metastatic adenocarcinoma of the prostate. -- The value of pre-treatment prognostic factors including stage, grade and PSA value will be presented, and their value in determining therapeutic strategies will be discussed. -- Controversies involving the simulation process and treatment design will be presented. The value of CT scanning, Beams-Eye View, 3-D planning, intravesicle, intraurethral and rectal contrast will be presented. The significance of prostate and patient movement and strategies for dealing with them will be presented. -- The management of low stage, low to intermediate grade prostate cancer will be discussed. The dose, volume and timing of irradiation will be discussed as will the role of neo-adjuvant hormonal therapy, neutron irradiation and brachytherapy. The current status of radical prostatectomy and cryotherapy will be summarized. Treatment of locally advanced, poorly differentiated prostate cancer will be presented including a discussion of neo-adjuvant and adjuvant hormones, dose-escalation and neutron irradiation. -- Strategies for post-radiation failures will be presented including data on cryotherapy, salvage prostatectomy and hormonal therapy (immediate, delayed and/or intermittent). New areas for investigation will be reviewed. -- The management of patients post prostatectomy will be reviewed. Data on adjuvant radiation and therapeutic radiation for biochemical or clinically relapsed patients will be presented. This course hopes to present a realistic and pragmatic overview for treating patients with non-metastatic prostatic cancer

  8. Beam position and phase measurements of microampere beams at the Michigan State University REA3 facility

    CERN Document Server

    Crisp, J; Durickovic, B; Kiupel, G; Krause, S; Leitner, D; Nash, S; Rodriguez, J A; Russo, T; Webber, R; Wittmer, W; Eddy, N; Briegel, C; Fellenz, B; Slimmer, D; Wendt, M

    2013-01-01

    A high power CW, heavy ion linac will be the driver accelerator for the Facility for Rare Isotope Beams (FRIB) being designed at Michigan State University (MSU). The linac requires a Beam Position Monitoring (BPM) system with better than 100 micron resolution at 100 microamperes beam current. A low beam current test of the candidate technology, button pick-ups and direct digital down-conversion signal processing, was conducted in the ReA3 re-accelerated beam facility at Michigan State University. The test is described. Beam position and phase measurement results, demonstrating ~250 micron and ~1.5 degree resolution in a 45 kHz bandwidth for a 1.0 microampere beam current, are reported.

  9. Beam tests on a proton linac booster for hadron therapy

    CERN Document Server

    De Martinis, C; Berra, P; Birattari, C; Calabretta, L; Crandall, K; Giove, D; Masullo, M R; Mauri, M; Rosso, E; Rovelli, A; Serafini, L; Szeless, Balázs; Toet, D Z; Vaccaro, Vittorio G; Weiss, M; Zennaro, R

    2002-01-01

    LIBO is a 3 GHz modular side-coupled proton linac booster designed to deliver beam energies up to 200 MeV, as required for the therapy of deep seated tumours. The injected beam of 50 to 70 MeV is produced by a cyclotron like those in several hospitals and research institutes. A full-scale prototype of the first module with an input/output energy of 62/74 MeV, respectively, was designed and built in 1999 and 2000. Full power RF tests were carried out successfully at CERN using a test facility at LIL at the end of the year 2000. In order to prove the feasibility of the acceleration process, an experimental setup with this module was installed at the INFN Laboratorio Nazionale del Sud (LNS) in Catania during 2001. The superconducting cyclotron provided the 62 MeV test beam. A compact solid-state RF modulator with a 4 MW klystron, made available by IBA-Scanditronix, was put into operation to power the linac. In this paper the main features of the accelerator are reviewed and the experimental results obtained duri...

  10. Defocusing beam line design for an irradiation facility at the TAEA SANAEM Proton Accelerator Facility

    Science.gov (United States)

    Gencer, A.; Demirköz, B.; Efthymiopoulos, I.; Yiğitoğlu, M.

    2016-07-01

    Electronic components must be tested to ensure reliable performance in high radiation environments such as Hi-Limu LHC and space. We propose a defocusing beam line to perform proton irradiation tests in Turkey. The Turkish Atomic Energy Authority SANAEM Proton Accelerator Facility was inaugurated in May 2012 for radioisotope production. The facility has also an R&D room for research purposes. The accelerator produces protons with 30 MeV kinetic energy and the beam current is variable between 10 μA and 1.2 mA. The beam kinetic energy is suitable for irradiation tests, however the beam current is high and therefore the flux must be lowered. We plan to build a defocusing beam line (DBL) in order to enlarge the beam size, reduce the flux to match the required specifications for the irradiation tests. Current design includes the beam transport and the final focusing magnets to blow up the beam. Scattering foils and a collimator is placed for the reduction of the beam flux. The DBL is designed to provide fluxes between 107 p /cm2 / s and 109 p /cm2 / s for performing irradiation tests in an area of 15.4 cm × 21.5 cm. The facility will be the first irradiation facility of its kind in Turkey.

  11. National facility for neutron beam research

    Indian Academy of Sciences (India)

    K R Rao

    2004-07-01

    In this talk, the growth of neutron beam research (NBR) in India over the past five decades is traced beginning with research at Apsara. A range of problems in condensed matter physics could be studied at CIRUS, followed by sophisticated indegenous instrumentation and research at Dhruva. The talk ends with an overview of current scenario of NBR world-wide and future of Indian activities.

  12. Spallation RI beam facility and heavy element nuclear chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Nagame, Yuichiro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-11-01

    An outline of the spallation RI (Radioactive Ion) beam facility is presented. Neutron-rich nuclides are produced in the reaction of high intensity (10-1000 {mu}A) protons with energy of 1.5 GeV and an uranium carbide target. Produced nuclides are ionized in an isotope separator on-line (ISOL) and accelerated by the JAERI tandem and the booster linac. Current progress and a future project on the development of the RI beam facility are given. Studies of transactinide elements, including the synthesis of superheavy elements, nuclear structure far from stability, and RI-probed material science are planned with RI beams. An outlook of the transactinide nuclear chemistry studies using neutron-rich RI beams is described. (author)

  13. SPIRaL: A radioactive ion beam facility at GANIL

    International Nuclear Information System (INIS)

    The SPIRaL project makes use of the very high intensity ion beams soon available at GANIL (over 1013 pps at 95 MeV/u from He to Ar) to produce radioactive nuclei by the ISOL method. The facility will consist of a production target situated close to an ECRIS specially designed for this purpose, a very low energy beam line, a k=265 compact cyclotron as postaccelerator (2 to 20 MeV/u according to the Q/A factor), a medium energy beam line transferring the radioactive beams into the existing experimental rooms through the α spectrometer. The whole facility will be installed at the end of the existing machine. (author) 4 refs., 3 figs

  14. The high-energy dual-beam facility

    International Nuclear Information System (INIS)

    This proposal presents a new experimental facility at the Kernforschungszentrum Karlsruhe (KfK) to study the effects of irradiation on the first wall and blanket materials of a fusion reactor. A special effort is made to demonstrate the advantages of the Dual Beam Technique (DBT) as a future research tool for materials development within the European Fusion Technology Programme. The Dual-Beam-Technique allows the production both of helium and of damage in thick metal and ceramic specimens by simultaneous irradiation with high energy alpha particles and protons produced by the two KfK cyclotrons. The proposal describes the Dual Beam Technique the planned experimental activities and the design features of the Dual Beam Facility presently under construction. (orig.)

  15. Beam positioning stability analysis on large laser facilities

    Institute of Scientific and Technical Information of China (English)

    Fang; Liu; Zhigang; Liu; Liunian; Zheng; Hongbiao; Huang; Jianqiang; Zhu

    2013-01-01

    Beam positioning stability in a laser-driven inertial confinement fusion(ICF) facility is a vital problem that needs to be fixed. Each laser beam in the facility is transmitted in lots of optics for hundreds of meters, and then targeted in a micro-sized pellet to realize controllable fusion. Any turbulence in the environment in such long-distance propagation would affect the displacement of optics and further result in beam focusing and positioning errors. This study concluded that the errors on each of the optics contributed to the target, and it presents an efficient method of enhancing the beam stability by eliminating errors on error-sensitive optics. Optimizations of the optical system and mechanical supporting structures are also presented.

  16. The SPES Radioactive-Ion Beam Facility of INFN

    Science.gov (United States)

    de Angelis, G.; Prete, G.; Andrighetto, A.; Manzolaro, M.; Corradetti, S.; Scarpa, D.; Rossignoli, M.; Monetti, A.; Lollo, M.; Calderolla, M.; Vasquez, J.; Zafiropoulos, D.; Sarchiapone, L.; Benini, D.; Favaron, P.; Rigato, M.; Pegoraro, R.; Maniero, D.; Comunian, M.; Maggiore, M.; Lombardi, A.; Piazza, L.; Porcellato, A. M.; Roncolato, C.; Bisoffi, G.; Pisent, A.; Galatà, A.; Giacchini, M.; Bassato, G.; Canella, S.; Gramegna, F.; Valiente, J.; Bermudez, J.; Mastinu, P. F.; Esposito, J.; Wyss, J.; Russo, A.; Zanella, S.; Calabretta, L.

    2015-11-01

    A new radioactive-ion beam (RIB) facility (SPES) is presently under construction at the Legnaro National Laboratories of INFN. The SPES facility is based on the ISOL method using a UCx direct target able to sustain a power of 10 kW. The primary proton beam will be provided by a high-current cyclotron accelerator with energy of 35-70 MeV and a beam current of 0.2-0.5 mA. Neutron-rich radioactive ions will be produced by proton-induced fission on a uranium target at an expected fission rate of the order of 1013 fissions per second. After ionization and selection the exotic isotopes will be re-accelerated by the ALPI superconducting LINAC at energies of 10A MeV for masses in the region A=130 amu. The expected secondary beam rates are of the order of 107-109 pps. The aim of the SPES facility is to deliver high-intensity radioactive-ion beams of neutron-rich nuclei for nuclear physics research, as well as to be an interdisciplinary research center for radioisotope production for medicine and for neutron beams.

  17. Two Effective Heuristics for Beam Angle Optimization in Radiation Therapy

    CERN Document Server

    Yarmand, Hamed

    2013-01-01

    In radiation therapy, mathematical methods have been used for optimizing treatment planning for delivery of sufficient dose to the cancerous cells while keeping the dose to critical surrounding structures minimal. This optimization problem can be modeled using mixed integer programming (MIP) whose solution gives the optimal beam orientation as well as optimal beam intensity. The challenge, however, is the computation time for this large scale MIP. We propose and investigate two novel heuristic approaches to reduce the computation time considerably while attaining high-quality solutions. We introduce a family of heuristic cuts based on the concept of 'adjacent beams' and a beam elimination scheme based on the contribution of each beam to deliver the dose to the tumor in the ideal plan in which all potential beams can be used simultaneously. We show the effectiveness of these heuristics for intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) on a clinical liver case.

  18. Beam Intensity and Energy Control for the SPIRAL2 Facility

    OpenAIRE

    Jamet, C.; André, T.; Ducoudret, B.; Doutressoulles, C.; Le Coz, W.; Ledu, G.; Leloir, S.; Loret, S.

    2012-01-01

    TUPB029 - ISBN 878-3-95450-122-9 International audience The first part of the SPIRAL2 facility, which entered last year in the construction phase at GANIL in France, consists of an ion source, a deuteron and a proton source, a RFQ and a superconducting linear accelerator delivering high intensities, up to 5 mA and 40 MeV for the deuteron beams. Diagnostic developments have been done to control both beam intensity and energy by non-interceptive methods at the linac exit. The beam current...

  19. CERN accelerator school: Antiprotons for colliding beam facilities

    International Nuclear Information System (INIS)

    This is a specialized course which addresses a wide spectrum of theoretical and technological problems confronting the designer of an antiproton facility for high-energy-physics research. A broad and profound basis is provided by the lecturers' substantial experience gained over many years with CERN's unique equipment. Topics include beam optics, special lattices for antiproton accumulation and storage rings, antiproton production, stochastic cooling, acceleration and storage, r.f. noise, r.f. beam manipulations, beam-beam interaction, beam stability due to ion accumulation, and diagnostics. The SPS (Super Proton Synchrotron) panti p collider, LEAR (the Low Energy Antiproton Ring at CERN), antiprotons in the ISR (Intersecting Storage Rings), the new antiproton collector (ACOL) and gas jet targets are also discussed. A table is included listing the parameters of all CERN's accelerators and storage rings. See hints under the relevant topics. (orig./HSI)

  20. beam timing diagnostic for the OMEGA laser facility

    Science.gov (United States)

    Katz, J.; Donaldson, W. R.; Huff, R.; Hill, E. M.; Kelly, J. H.; Kwiatkowski, J.; Brannon, R. B.

    2015-08-01

    The Omega Laser Facility at the University of Rochester's Laboratory for Laser Energetics is a 60-beam system used for inertial confinement fusion experiments. Uniform drive of the target surface requires precise beam timing to achieve accurate power balance. A new diagnostic has been implemented for measuring the relative beam-to-beam arrival time of each of the 60 beamlines. A 900-μm spherical diffuser placed at the target chamber center serves as a quasi-isotropic scattering source that allows a fixed optical detector to view light from any individual beamline. During a beam-timing run, the OMEGA laser is configured to generate frequency-tripled, 351-nm ultraviolet (UV) pulses with energies of ~50 pJ at a repetition rate of 5 Hz. Light from the scattering target is optically relayed to a fast photomultiplier tube and recorded on a digital oscilloscope. A portion of the original infrared (IR) seed pulse is fiber optically delivered to the beam-timing oscilloscope and recorded using a photodiode. By recording the scattered UV pulse and the IR seed on the same oscilloscope trace, a jitter-free measurement of the beam's arrival time can be made. Discrepancies in beam timing are corrected by adjusting the total optical path length of the beamlines. Typical variation in the measured arrival times of all 60 OMEGA beams after adjustment is <5 ps root mean square

  1. Thin silicon strip detectors for beam monitoring in Micro-beam Radiation Therapy

    International Nuclear Information System (INIS)

    Microbeam Radiation Therapy (MRT) is an emerging cancer treatment that is currently being developed at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France. This technique uses a highly collimated and fractionated X-ray beam array with extremely high dose rate and very small divergence, to benefit from the dose-volume effect, thus sparing healthy tissue. In case of any beam anomalies and system malfunctions, special safety measures must be installed, such as an emergency safety shutter that requires continuous monitoring of the beam intensity profile. Within the 3DMiMic project, a novel silicon strip detector that can tackle the special features of MRT, such as the extremely high spatial resolution and dose rate, has been developed to be part of the safety shutter system. The first prototypes have been successfully fabricated, and experiments aimed to demonstrate their suitability for this unique application have been performed. Design, fabrication and the experimental results as well as any identified inadequacies for future optimisation are reported and discussed in this paper

  2. Thin silicon strip detectors for beam monitoring in Micro-beam Radiation Therapy

    Science.gov (United States)

    Povoli, M.; Alagoz, E.; Bravin, A.; Cornelius, I.; Bräuer-Krisch, E.; Fournier, P.; Hansen, T. E.; Kok, A.; Lerch, M.; Monakhov, E.; Morse, J.; Petasecca, M.; Requardt, H.; Rosenfeld, A. B.; Röhrich, D.; Sandaker, H.; Salomé, M.; Stugu, B.

    2015-11-01

    Microbeam Radiation Therapy (MRT) is an emerging cancer treatment that is currently being developed at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France. This technique uses a highly collimated and fractionated X-ray beam array with extremely high dose rate and very small divergence, to benefit from the dose-volume effect, thus sparing healthy tissue. In case of any beam anomalies and system malfunctions, special safety measures must be installed, such as an emergency safety shutter that requires continuous monitoring of the beam intensity profile. Within the 3DMiMic project, a novel silicon strip detector that can tackle the special features of MRT, such as the extremely high spatial resolution and dose rate, has been developed to be part of the safety shutter system. The first prototypes have been successfully fabricated, and experiments aimed to demonstrate their suitability for this unique application have been performed. Design, fabrication and the experimental results as well as any identified inadequacies for future optimisation are reported and discussed in this paper.

  3. A molecular beam epitaxy facility for in situ neutron scattering

    International Nuclear Information System (INIS)

    A molecular beam epitaxy (MBE) facility has been built to enable in situ neutron scattering measurements during growth of epitaxial layers. While retaining the full capabilities of a research MBE chamber, this facility has been optimized for polarized neutron reflectometry measurements. Optimization includes a compact lightweight portable design, a neutron window, controllable magnetic field, deposition across a large 76 mm diameter sample with exceptional flux uniformity, and sample temperatures continuously controllable from 38 to 1375 K. A load lock chamber allows for sample insertion, storage of up to 4 samples, and docking with other facilities. The design and performance of this chamber are described here.

  4. Neutron beam facilities at the Replacement Research Reactor, ANSTO

    International Nuclear Information System (INIS)

    The exciting development for Australia is the construction of a modern state-of-the-art 20-MW Replacement Research Reactor which is currently under construction to replace the aging reactor (HIFAR) at ANSTO in 2006. To cater for advanced scientific applications, the replacement reactor will provide not only thermal neutron beams but also a modern cold-neutron source moderated by liquid deuterium at approximately -250 deg C, complete with provision for installation of a hot-neutron source at a later stage. The latest 'supermirror' guides will be used to transport the neutrons to the Reactor Hall and its adjoining Neutron Guide Hall where a suite of neutron beam instruments will be installed. These new facilities will expand and enhance ANSTO's capabilities and performance in neutron beam science compared with what is possible with the existing HIFAR facilities, and will make ANSTO/Australia competitive with the best neutron facilities in the world. Eight 'leading-edge' neutron beam instruments are planned for the Replacement Research Reactor when it goes critical in 2006, followed by more instruments by 2010 and beyond. Up to 18 neutron beam instruments can be accommodated at the Replacement Research Reactor, however, it has the capacity for further expansion, including potential for a second Neutron Guide Hall. The first batch of eight instruments has been carefully selected in conjunction with a user group representing various scientific interests in Australia. A team of scientists, engineers, drafting officers and technicians has been assembled to carry out the Neutron Beam Instrument Project to successful completion. Today, most of the planned instruments have conceptual designs and are now being engineered in detail prior to construction and procurement. A suite of ancillary equipment will also be provided to enable scientific experiments at different temperatures, pressures and magnetic fields. This paper describes the Neutron Beam Instrument Project and gives

  5. On the capabilities of present radioactive beam facilities

    International Nuclear Information System (INIS)

    The possibilities and limitations of present, i.e. existing, radioactive beam facilities are reviewed. After a definition of the criteria used for an evaluation, the discussion is mainly oriented on the complementarity between the ISOL-method and fast recoil separators. (author) 76 refs., 7 figs., 2 tabs

  6. Fermilab Test Beam Facility Annual Report. FY 2014

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States). et al.

    2015-01-01

    Fermilab Test Beam Facility (FTBF) operations are summarized for FY 2014. It is one of a series of publications intended to gather information in one place. In this case, the information concerns the individual experiments that ran at FTBF. Each experiment section was prepared by the relevant authors, and was edited for inclusion in this summary.

  7. Developing of the protocol for electron beam food irradiation facility

    International Nuclear Information System (INIS)

    By establishing the needs for institution of new technologies in the process of food processing, in this case a randomized choice of electron beam accelerator facility, arises the need for designing a protocol for safe and secure performance of the facility. The protocol encompasses safety and security measures for protection from ionizing radiation of the individuals who work at the facility, as well as, the population and the environment in the immediate neighborhood of the facility. Thus, the adopted approach is the establishment of appropriate systems responding to the protocol. Dosimetry system, which includes appropriate procedures for accurate measure and recording of the absorbed dose values, according to the provisions for protection from ionizing radiation. Ionizing radiation protection system and providing the safety and security of the facility for food processing by means of ionizing radiation. System for providing quality and safety control of the facility for food processing by means of ionizing radiation. Pursuant to the designed a protocol for safe and secure performance of the facility for electron beam food processing, contributes to protection against ionizing radiation as occupationally exposed persons as well the population. (Author)

  8. RIKEN RI beam facility and its physics programme

    International Nuclear Information System (INIS)

    A construction of the radioactive ion beam facility has been started at RIKEN, which is a project to construct a four-sector ring cyclotron (IRC-4) and a six-sector superconducting ring cyclotron (SRC-6), experimental storage rings (MUSES) and an experimental facility. Heavy ions are to be accelerated to energies of up to 400A MeV for light nuclei and 150A MeV for the heaviest nuclei by the SRC-6 and up to 1400A MeV in the MUSES. Wide varieties of radioactive nuclear beams are to be supplied as secondary beams. Electrons, stable nuclei, and highly charged ions in addition to radioactive nuclei can be stored in the storage rings. The MUSES provides various collision methods, such as colliding, merging and internal target modes. A few of the new nuclear-physics opportunities are discussed briefly. (author)

  9. Progress in neutron beam development at the HFR Petten (feasibility study for a BNCT facility)

    International Nuclear Information System (INIS)

    Boron Neutron Capture Therapy, using intermediate energy neutrons to achieve the deep penetration essential for treating brain tumours, can be implemented with a filtered reactor neutron beam. This is designed to minimize the mean energy of the neutrons to keep proton recoil damage to the scalp within normal tissue tolerance limits whilst delivering the required thermal neutron fluence to the tumour over a reasonably short period. This can only be realized in conjunction with a high power density reactor. At the Joint Research Centre Petten an optimized neutron filter is currently being built for installation into the HB11 beam tube of the High Flux Reactor HFR. Part of the development leading to this design has been an extensive study of broad spectrum, filtered beam performance on the HB7 beam tube facility. A wide range of calculations was performed using the Monte Carlo code, MCPN, supported by validation experiments in which several filter configuration incorporating aluminium, sulphur, liquid argon, titanium and cadmium were installed for low power measurements of the neutron fluence rate, neutron spectra and beam gamma-ray contamination. The measurements were carried out within a successful European collaboration. Evaluations were made of the reactor core edge and unfiltered beam spectra, for comparison with MCNP calculations. Multi-foil activation methods and also gamma dose determination in the filtered beam using thermo-luminescent detectors were performed by the ECN. The Harwell/ Birmingham University collaborators undertook the neutron spectrum measurements in the filtered beam. proton recoil spectrometry was used above 30 keV, combined with a multi-sphere and BF3 chamber response modification technique. Subsequent spectrum adjustment was carried out with the SENSAK code. The agreement between the calculated and measured spectra has given confidence in the reactor and filter modelling methods used to design the HB11 therapy facility. (author). 12 refs

  10. Beam simultaneity results in the Helios laser fusion facility

    International Nuclear Information System (INIS)

    The operation of the beam simultaneity system of the 10-kJ, 20-TW, eight-beam Helios CO2 laser experimental fusion facility, which is required to ensure that the eight laser beams arrive at the target within 33 picosec of each other, is discussed. The system measures relative beam path lengths with a resolution of 1 mm based on the comparison of electro-optically modulated signals from a CW CO2 laser injected into the eight beam paths and a reference path and reflected off a reflecting sphere in the target chamber. Signal-to-electrical-noise and signal-to-optical-noise ratios are both greater than 500, with the noise composed of components at 1 and 0.1 Hz in both the reference and beam paths. It is estimated that each optical beam path can be measured to within 3 mm, and that the system can be realigned with less than 3 mm path change. Beam simultaneity is finally limited by dispersive and dynamical effects of the gain medium of the triple pass power amplifiers, which have not yet been measured, but are believed to be compatible with the goal accuracy (10 picosec) and resolution (33 picosec) of the system

  11. Preliminary design of a reduced cost proton therapy facility using a compact, high field isochronous cyclotron

    International Nuclear Information System (INIS)

    It is generally agreed that, among the different kinds of radiations usable for radio-therapy, high energy proton beams exhibit the best ballistic specificity. However, the development of proton therapy has been hindered by the size, cost and complexity of high energy accelerators. An attempt to design not only an accelerator, but a complete proton therapy facility is presented, where the size, the investment, the complexity and the cost of operation would be minimized. A non-superconducting isochronous cyclotron has been selected for this purpose. (R.P.) 5 refs.; 2 figs.; 2 tabs

  12. Radiological physics of heavy charged-particle beams used for therapy

    International Nuclear Information System (INIS)

    The beams available for biological investigations at the Bevatron or at the Bevalac range from helium to iron ions. However, only carbon, neon, and argon beams have been used for therapy. The treatment techniques are arbitrarily divided into two categories: small field and large field irradiation. Examples of the small field treatments are pituitary irradiation, which generaly utilizes the plateau portion of the helium depth-dose curve, and treatment of ocular melanoma, which uses a modified Bragg peak of the helium beam. Large field treatments for cancer therapy generally requires a beam that has a large uniform transverse profile and a modified Bragg peak. Procedures and instrumentation for patient irradiations at the Bevatron/Bevalac have been based on the prior experience obtained at the 184-inch Synchrocyclotron, and for that reason both facilities are discussed

  13. A light ion beam driver for the Laboratory Microfusion Facility

    International Nuclear Information System (INIS)

    The Laboratory Microfusion Facility (LMF) is being planned to develop high-grain, high-yield (200 MJ-1000 MJ) ICF targets for applications to nuclear weapons effects simulation, thermonuclear weapons physics, and energy production. It is expected that a 1000-MJ yield will require ∼10--20 MJ input energy to the target. The light-ion beam driver concept for the LMF consists of 36 accelerator modules that drive independent Li+ ion diodes. Each ion beam is extracted from an annular ion diode and propagated to a solenoidal lens located near the wall of the target chamber. This magnetic lens focuses the beam on to the pellet located at the center of the target chamber. The temporal shape of the power pulse delivered to the target is controlled by the synchronized firing of the accelerator modules. This paper presents a status of the light-ion beam LMF driver concept

  14. A state-of-the-art epithermal neutron irradiation facility for neutron capture therapy

    International Nuclear Information System (INIS)

    At the Massachusetts Institute of Technology (MIT) the first fission converter-based epithermal neutron beam (FCB) has proven suitable for use in clinical trials of boron neutron capture therapy (BNCT). The modern facility provides a high intensity beam together with low levels of contamination that is ideally suited for use with future, more selective boron delivery agents. Prescriptions for normal tissue tolerance doses consist of 2 or 3 fields lasting less than 10 min each with the currently available beam intensity, that are administered with an automated beam monitoring and control system to help ensure safety of the patient and staff alike. A quality assurance program ensures proper functioning of all instrumentation and safety interlocks as well as constancy of beam output relative to routine calibrations. Beam line shutters and the medical room walls provide sufficient shielding to enable access and use of the facility without affecting other experiments or normal operation of the multipurpose research reactor at MIT. Medical expertise and a large population in the greater Boston area are situated conveniently close to the university, which operates the research reactor 24 h a day for approximately 300 days per year. The operational characteristics of the facility closely match those established for conventional radiotherapy, which together with a near optimum beam performance ensure that the FCB is capable of determining whether the radiobiological promise of NCT can be realized in routine practice

  15. Optics design of beam for proton therapy gantry based on Geant4

    International Nuclear Information System (INIS)

    Background: Rotating Gantry is widely used in proton therapy due to its small radiation damage toward the normal tissue around the tumor. Proton therapy gantry optics which plays an important role in rotating gantry is under design in Shanghai Advanced Proton Therapy Facility (APTRON). Purpose: To generate a circular beam profile at iso-center while the gantry rotates with different angles. Methods: Different gantry optics matching techniques are used to calculate the beam optics. These methods include the round-beam method (RBM) or not in the front of vacuum window, and use RBM at iso-center. The simulations of beam profile at iso-center after the beam passing through nozzle and body tissue are carried out with Geant4 software. Results: The beam profile at iso-center can be taken as similar among three cases, and there is slight improvement using RBM. Conclusions: The designed proton therapy gantry optics is intensive to the rotation angle and is applicable for the real application. (authors)

  16. Proton Beam Therapy and Accountable Care: The Challenges Ahead

    International Nuclear Information System (INIS)

    Purpose: Proton beam therapy (PBT) centers have drawn increasing public scrutiny for their high cost. The behavior of such facilities is likely to change under the Affordable Care Act. We modeled how accountable care reform may affect the financial standing of PBT centers and their incentives to treat complex patient cases. Methods and Materials: We used operational data and publicly listed Medicare rates to model the relationship between financial metrics for PBT center performance and case mix (defined as the percentage of complex cases, such as pediatric central nervous system tumors). Financial metrics included total daily revenues and debt coverage (daily revenues − daily debt payments). Fee-for-service (FFS) and accountable care (ACO) reimbursement scenarios were modeled. Sensitivity analyses were performed around the room time required to treat noncomplex cases: simple (30 minutes), prostate (24 minutes), and short prostate (15 minutes). Sensitivity analyses were also performed for total machine operating time (14, 16, and 18 h/d). Results: Reimbursement under ACOs could reduce daily revenues in PBT centers by up to 32%. The incremental revenue gained by replacing 1 complex case with noncomplex cases was lowest for simple cases and highest for short prostate cases. ACO rates reduced this incremental incentive by 53.2% for simple cases and 41.7% for short prostate cases. To cover daily debt payments after ACO rates were imposed, 26% fewer complex patients were allowable at varying capital costs and interest rates. Only facilities with total machine operating times of 18 hours per day would cover debt payments in all scenarios. Conclusions: Debt-financed PBT centers will face steep challenges to remain financially viable after ACO implementation. Paradoxically, reduced reimbursement for noncomplex cases will require PBT centers to treat more such cases over cases for which PBT has demonstrated superior outcomes. Relative losses will be highest for those

  17. Biological basis of heavy ion beams for cancer therapy

    International Nuclear Information System (INIS)

    Fast neutron therapy has started firstly and proton therapy has commenced secondly, fast neutron shows better biological effects compared to conventional radiations but its dose distribution is not good, and proton demonstrates excellent dose distribution but its biological effects are almost the same as that of conventional radiations. On the other hand, negative pi-mesons and heavy ions indicate high radiobiological effect and excellent dose distribution, therefore these particle radiations is considered to be more attractive for radiotherapeutic radiations to enhance cure rate of cancers. The biological strong points of these particles are as follows : 1) cells exposed to these particle radiations shows less recovery after irradiation compared to conventional radiations, 2) these radiations show high biological effects (high value of relative biological effectiveness = RBE) when the same dose is given, 3) big effects on hypoxic cells which exsist in tumor, i.e. the value of oxygen enhancement ratio (OER) is low, 4) the differences in radiosensitivity by stages of cell cycle are not so great (data was not shown in present paper), 5) biological effects at prepeak plateau region in depth dose curve formed by these particle radiations is less than that at peak region (therefore, if beam is modulated to cover tumor at spraed out broad peak, tumors is given more biological effect compared to normal tissues which is to be exposed to radiations at prepaeak region). Clinical trial using heavy ions are being performed at Lawrence Berkeley Laboratory which is only one facility to be able to try clinical trial. The results of clinical trials at Lawrence Berkeley Laboratory suggest to be very prospective to enhance tumor cure rate, however it is too early to estimate the effect of heavy ion therapy. (J.P.N.)

  18. Predicted ion beam performance of the nuclear structure facility

    International Nuclear Information System (INIS)

    In the forward planning of any experimental programme for a new facility such as the NSF, it is important to have realistic estimates of the types, intensities and qualities of the beams which will be available when the accelerator starts operation. The factors which must be considered when making such estimates for an electrostatic tandem accelerator are as follows: (a) The output performance of the primary negative ion source. (b) The transmission of the injection optics and low-energy acceleration tube. (c) The charge states available at the first stripper and the effects of multiple scattering and straggling at this stripper. (d) The acceptance of the high energy accelerator tube following charge state selection, when appropriate, after the first stripper. (e) The use, positioning, multiple scattering and straggling of any second stripper. (f) The beam intensity in the various charge states following this stripper. (g) The final intensity, energy, energy resolution and emittance of the beam in, usually, the most probable final charge state at the entrance to the main analysing magnet of the accelerator. These factors have been considered for the new large tandem accelerator for the Nuclear Structure Facility (NSF) at Daresbury. The final beams have been calculated for operation at 20 MV and 30 MV on the terminal and with a second stripper placed in the high energy tube for the heavier ions. On all cases considered, the final beam intensities are sufficiently large, and the emittance and energy spreads sufficiently small, to allow straightforward operation for all foreseeable experiments. (author)

  19. CEBAF [Continuous Electron Beam Accelerator Facility] design report

    International Nuclear Information System (INIS)

    This book describes the conceptual design of, and the planning for, the Continuous Electron Beam Accelerator Facility (CEBAF), which will be a high-intensity, continuous-wave electron linear accelerator (linac) for nuclear physics. Its principal scientific goal is to understand the quark structure, behavior, and clustering of individual nucleons in the nuclear medium, and simultaneously to understand the forces governing this behavior. The linac will consist of 1 GeV of accelerating structure, split into two antiparallel 0.5-GeV segments. The segments will be connected by a beam transport system to circulate the electron beams from one segment to the other for up to four complete passes of acceleration. The maximum beam energy will be 4 GeV at a design current of 200 microamperes. The accelerator complex will also include systems to extract three continuous beams from the linac and to deliver them to three experimental halls equipped with detectors and instrumentation for nuclear physics research. The accelerating structure will be kept superconducting within insulated cryostats filled with liquid helium produced at a central helium refrigerator and distributed to the cryostats via insulated transfer lines. An injector, instrumentation and controls for the accelerator, radio-frequency power systems, and several support facilities will also be provided. A cost estimate based on the Work Breakdown Structure has been completed. Assuming a five-year construction schedule starting early in FY 1987, the total estimated cost is $236 million (actual year dollars), including contingency

  20. Anesthesia for pediatric external beam radiation therapy

    International Nuclear Information System (INIS)

    Background: For very young patients, anesthesia is often required for radiotherapy. This results in multiple exposures to anesthetic agents over a short period of time. We report a consecutive series of children anesthetized for external beam radiation therapy (EBRT). Methods: Five hundred twelve children ≤ 16 years old received EBRT from January 1983 to February 1996. Patient demographics, diagnosis, anesthesia techniques, monitoring, airway management, complications, and outcome were recorded for the patients requiring anesthesia. Results: One hundred twenty-three of the 512 children (24%) required 141 courses of EBRT with anesthesia. Anesthetized patients ranged in age from 20 days to 11 years (mean 2.6 ± 1.8 ). The frequency of a child receiving EBRT and requiring anesthesia by age cohort was: ≤ 1 year (96%), 1-2 years (93%), 2-3 years (80%), 3-4 years (51%), 4-5 years (36%), 5-6 years (13%), 6-7 years (11%), and 7-16 years (0.7%). Diagnoses included: primary CNS tumor (28%), retinoblastoma (27%), neuroblastoma (20%), acute leukemia (9%), rhabdomyosarcoma (6%), and Wilms' tumor (4%). Sixty-three percent of the patients had been exposed to chemotherapy prior to EBRT. The mean number of anesthesia sessions per patient was 22 ± 16. Seventy-eight percent of the treatment courses were once daily and 22% were twice daily. Anesthesia techniques included: short-acting barbiturate induction + inhalation maintenance (21%), inhalation only (20%), ketamine (19%), propofol only (12%), propofol induction + inhalation maintenance (7%), ketamine induction + inhalation maintenance (6%), ketamine or short-acting barbiturate induction + inhalation maintenance (6%). Monitoring techniques included: EKG (95%), O2 saturation (93%), fraction of inspired O2 (57%), and end-tidal CO2 (55%). Sixty-four percent of patients had central venous access. Eleven of the 74 children with a central line developed sepsis (15%): 6 of the 11 were anesthetized with propofol (55%), 4 with a short

  1. Dhruva reactor -- a high flux facility for neutron beam research

    International Nuclear Information System (INIS)

    Dhruva reactor, the highest flux thermal neutron source in India has been operating at full power of 100 MW over the past two years. Several advanced facilities like the cold source, guides, etc. are being installed for neutron beam research in condensed matter. A large number and variety of neutron spectrometers are operational. This paper deals with the basic advantages that one can derive from neutron scattering investigations and gives a brief description of the instruments that are developed and commissioned at Dhruva for neutron beam research. (author). 3 figs

  2. Development and Commissioning of an External Beam Facility in the Union College Ion Beam Analysis Laboratory

    Science.gov (United States)

    Yoskowitz, Joshua; Clark, Morgan; Labrake, Scott; Vineyard, Michael

    2015-10-01

    We have developed an external beam facility for the 1.1-MV tandem Pelletron accelerator in the Union College Ion Beam Analysis Laboratory. The beam is extracted from an aluminum pipe through a 1 / 4 ' ' diameter window with a 7.5- μm thick Kapton foil. This external beam facility allows us to perform ion beam analysis on samples that cannot be put under vacuum, including wet samples and samples too large to fit into the scattering chamber. We have commissioned the new facility by performing proton induced X-ray emission (PIXE) analysis of several samples of environmental interest. These include samples of artificial turf, running tracks, and a human tooth with an amalgam filling. A 1.7-MeV external proton beam was incident on the samples positioned 2 cm from the window. The resulting X-rays were measured using a silicon drift detector and were analyzed using GUPIX software to determine the concentrations of elements in the samples. The results on the human tooth indicate that while significant concentrations of Hg, Ag, and Sn are present in the amalgam filling, only trace amounts of Hg appear to have leached into the tooth. The artificial turf and running tracks show rather large concentrations of a broad range of elements and trace amounts of Pb in the turf infill.

  3. Proposal for an intense slow positron beam facility at PSI

    International Nuclear Information System (INIS)

    In the domain of condensed matter physics and materials sciences monoenergetic slow positrons in the form of highest intensity beams are demonstrated to be extreamly useful and considered to be highly needed. This conclusion has been reached and the scientific relevance of the positron probe has been highlighted at an international workshop in November 1989 at PSI, where the state of the art and the international situation on slow positron beams, the fields of application of intense beams and the technical possibilities at PSI for installing intense positron sources have been evaluated. The participants agreed that a high intensity beam as a large-scale user facility at PSI would serve fundamental and applied research. The analysis of responses given by numerous members of a widespread positron community has revealed a large research potential in the domain of solid-state physics, atomic physics and surface, thin-film and defect physics, for example. The excellent feature of slow positron beams to be a suitable probe also for lattice defects near surfaces or interfaces has attracted the interest not only of science but also of industry.In this report we propose the installation of an intense slow positron beam facility at PSI including various beam lines of different qualities and based on the Cyclotron production of β+ emitting source material and on a highest efficiency moderation scheme which exceeds standard moderation efficiencies by two orders of magnitude. In its proposed form, the project is estimated to be realizable in the nineties and costs will amount to between 15 and 20 MSFr. (author) 10 figs., 6 tabs., 78 refs

  4. A safety system for a laser-beam utilising facility

    International Nuclear Information System (INIS)

    A safety system for a laser-beam utilising facility incorporates a safety enclosure and an infra-red monitoring system for detecting the development of hot spots at internal surfaces of the enclosure walls and ceiling which may occur as a result of stray laser radiation impinging on such surfaces. The development of a hot spot leads to shutting off the laser source or interruption of the beams by means of a shutter. The facility may be a welding or cutting apparatus and may be used with nuclear fuel elements. The monitoring system may be a scanning system. Two such scanning systems may be provided, scanning at different speeds, to detect respectively hot spots and the presence of a human body within the safety enclosure. (author)

  5. CEBAF [Continuous Electron Beam Accelerator Facility] scientific program

    International Nuclear Information System (INIS)

    The principal scientific mission of the Continuous Electron Beam Facility (CEBAF) is to study collective phenomena in cold (or normal) nucler matter in order to understand the structure and behavior of macroscopic systems constructed from nuclei. This document discusses in broad popular terms those issues which the CEBAF experimental and theoretical program are designed to address. Specific experimental programs currently planned for CEBAF are also reivewed. 35 refs., 19 figs

  6. ECR ion source based low energy ion beam facility

    Indian Academy of Sciences (India)

    P Kumar; G Rodrigues; U K Rao; C P Safvan; D Kanjilal; A Roy

    2002-11-01

    Mass analyzed highly charged ion beams of energy ranging from a few keV to a few MeV plays an important role in various aspects of research in modern physics. In this paper a unique low energy ion beam facility (LEIBF) set up at Nuclear Science Centre (NSC) for providing low and medium energy multiply charged ion beams ranging from a few keV to a few MeV for research in materials sciences, atomic and molecular physics is described. One of the important features of this facility is the availability of relatively large currents of multiply charged positive ions from an electron cyclotron resonance (ECR) source placed entirely on a high voltage platform. All the electronic and vacuum systems related to the ECR source including 10 GHz ultra high frequency (UHF) transmitter, high voltage power supplies for extractor and Einzel lens are placed on a high voltage platform. All the equipments are controlled using a personal computer at ground potential through optical fibers for high voltage isolation. Some of the experimental facilities available are also described.

  7. Study on external beam radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Mi Sook; Yoo, Seoung Yul; Yoo, Hyung Jun; Ji, Young Hoon; Lee, Dong Han; Lee, Dong Hoon; Choi, Mun Sik; Yoo, Dae Heon; Lee, Hyo Nam; Kim, Kyeoung Jung

    1999-04-01

    To develop the therapy technique which promote accuracy and convenience in external radiation therapy, to obtain the development of clinical treatment methods for the global competition. The contents of the R and D were 1. structure, process and outcome analysis in radiation therapy department. 2. Development of multimodality treatment in radiation therapy 3. Development of computation using networking techniques 4. Development of quality assurance (QA) system in radiation therapy 5. Development of radiotherapy tools 6. Development of intraoperative radiation therapy (IORT) tools. The results of the R and D were 1. completion of survey and analysis about Korea radiation therapy status 2. Performing QA analysis about ICR on cervix cancer 3. Trial of multicenter randomized study on lung cancers 4. Setting up inter-departmental LAN using MS NT server and Notes program 5. Development of ionization chamber and dose-rate meter for QA in linear accelerator 6. Development on optimized radiation distribution algorithm for multiple slice 7. Implementation on 3 dimensional volume surface algorithm and 8. Implementation on adaptor and cone for IORT.

  8. Study on external beam radiation therapy

    International Nuclear Information System (INIS)

    To develop the therapy technique which promote accuracy and convenience in external radiation therapy, to obtain the development of clinical treatment methods for the global competition. The contents of the R and D were 1. structure, process and outcome analysis in radiation therapy department. 2. Development of multimodality treatment in radiation therapy 3. Development of computation using networking techniques 4. Development of quality assurance (QA) system in radiation therapy 5. Development of radiotherapy tools 6. Development of intraoperative radiation therapy (IORT) tools. The results of the R and D were 1. completion of survey and analysis about Korea radiation therapy status 2. Performing QA analysis about ICR on cervix cancer 3. Trial of multicenter randomized study on lung cancers 4. Setting up inter-departmental LAN using MS NT server and Notes program 5. Development of ionization chamber and dose-rate meter for QA in linear accelerator 6. Development on optimized radiation distribution algorithm for multiple slice 7. Implementation on 3 dimensional volume surface algorithm and 8. Implementation on adaptor and cone for IORT

  9. Heavy Charged Particle Radiobiology: Using Enhanced Biological Effectiveness and Improved Beam Focusing to Advance Cancer Therapy

    OpenAIRE

    Allen, Christopher; Borak, Thomas B.; Tsujii, Hirohiko; Jac A Nickoloff

    2011-01-01

    Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilitie...

  10. Beamlines of the Biomedical Imaging and Therapy Facility at the Canadian Light Source - Part 2

    International Nuclear Information System (INIS)

    The BioMedical Imaging and Therapy (BMIT) facility provides a world class facility with unique synchrotron-specific imaging and therapy capabilities. This paper describes Insertion Device (ID) beamline 05ID-2 with the beam terminated in the first experimental hutch: POE-2. The experimental methods available in POE-2 include: Microbeam Radiation Therapy (MRT), Synchrotron Stereotactic Radiation Therapy (SSRT) and absorption imaging (projection and Computed Tomography (CT)). The source for the ID beamline is a multi-pole superconductive 4.3 T wiggler, which can generate ∼30 kW of radiative power and deliver dose as high as 3000 Gy/s required for MRT program. The optics in POE-1 hutch prepares either monochromatic or filtered white beam that is used in POE-2. The Double Crystal (DC), bent Laue monochromator will prepare a beam over 10 cm wide at sample point, while spanning an energy range appropriate for imaging studies of animals (20-100+ keV). The experimental hutch will have a flexible positioning system that can handle subjects up to 120 kg. Several different cameras will be available with resolutions ranging from 4 μm to 150 μm. The latest update on the status of 05B1-1 bending magnet (BM) beamline, described in Part 1 [1], is also included.

  11. Radiation shielding for the ITER neutral beam test facility

    International Nuclear Information System (INIS)

    The NB system for the International Thermonuclear Experimental Reactor (ITER) consists of two heating and current drive (H and CD) NB injectors and a diagnostic neutral beam (DNB) injector. The NB accelerates negative deuterium ions with maximum energy of 1 MeV and maximum beam current of 40 A. The ITER (H and CD) NB will be tested in the Neutral Beam Test Facility (NBTF) that will be located in Italy, near Padua. The performance test will be based on different operation phases starting with low energy hydrogen beam. In the initial testing phase for many months the machine will operate with hydrogen only and with deuteron at a reduced intensity suggesting the possibility of hosting the device in a light shielding room/area. In the paper the study performed to evaluate the minimum shielding needed in connection with the different operation phases is shown. The source terms were calculated starting from neutron source characterisation and then assessing article transport in the ITER NB structure with a mathematical model of the components geometry that was implemented into MCNP computer code. The neutron source definition was outlined considering both D-D and D-T neutron production. Shielding was assessed for hydrogen operation only and for 20, 60, 100 and 1000 kV (full energy) deuteron acceleration, accounting for the associated beam current intensity. Related results are presented and discussed in the paper. (author)

  12. Neutron beam facilities at the Australian Replacement Research Reactor

    International Nuclear Information System (INIS)

    Australia is building a research reactor to replace the HIFAR reactor at Lucas Heights by the end of 2005. Like HIFAR, the Replacement Research Reactor will be multipurpose with capabilities for both neutron beam research and radioisotope production. It will be a pool-type reactor with thermal neutron flux (unperturbed) of 4 x 1014 n/cm2/sec and a liquid D2 cold neutron source. Cold and thermal neutron beams for neutron beam research will be provided at the reactor face and in a large neutron guide hall. Supermirror neutron guides will transport cold and thermal neutrons to the guide hall. The reactor and the associated infrastructure, with the exception of the neutron beam instruments, is to be built by INVAP S.E. under contract. The neutron beam instruments will be developed by ANSTO, in consultation with the Australian user community. This status report includes a review the planned scientific capabilities, a description of the facility and a summary of progress to date. (author)

  13. Measurements and simulations of focused beam for orthovoltage therapy

    International Nuclear Information System (INIS)

    Purpose: Megavoltage photon beams are typically used for therapy because of their skin-sparing effect. However, a focused low-energy x-ray beam would also be skin sparing, and would have a higher dose concentration at the focal spot. Such a beam can be produced with polycapillary optics. MCNP5 was used to model dose profiles for a scanned focused beam, using measured beam parameters. The potential of low energy focused x-ray beams for radiation therapy was assessed. Methods: A polycapillary optic was used to focus the x-ray beam from a tungsten source. The optic was characterized and measurements were performed at 50 kV. PMMA blocks of varying thicknesses were placed between optic and the focal spot to observe any variation in the focusing of the beam after passing through the tissue-equivalent material. The measured energy spectrum was used to model the focused beam in MCNP5. A source card (SDEF) in MCNP5 was used to simulate the converging x-ray beam. Dose calculations were performed inside a breast tissue phantom. Results: The measured focal spot size for the polycapillary optic was 0.2 mm with a depth of field of 5 mm. The measured focal spot remained unchanged through 40 mm of phantom thickness. The calculated depth dose curve inside the breast tissue showed a dose peak several centimeters below the skin with a sharp dose fall off around the focus. The percent dose falls below 10% within 5 mm of the focus. It was shown that rotating the optic during scanning would preserve the skin-sparing effect of the focused beam. Conclusions: Low energy focused x-ray beams could be used to irradiate tumors inside soft tissue within 5 cm of the surface

  14. Radiation dermatitis following electron beam therapy

    International Nuclear Information System (INIS)

    Ten patients, who had been treated for mycosis fungoides with electron beam radiation ten or more years previously, were examined for signs of radiation dermatitis. Although most patients had had acute radiation dermatitis, only a few manifested signs of mild chronic changes after having received between 1,000 and 2,800 rads

  15. An irradiation facility with a vertical beam for radiobiological studies

    CERN Document Server

    Besserer, J; Dellert, M; Gahn, C; Moosburger, M; Pemler, P; Quicken, P; Distel, L; Schuessler, H

    1999-01-01

    A vertical beam facility for radiobiological experiments was designed and constructed at the Munich Tandem-Accelerator Laboratory. The main part of the facility is a 90 deg. dipole magnet bending the beam of protons or heavy particles into a vertical upward direction, which is advantageous for wet-cell irradiation. After collimation the beam is spread out passively by thin scattering foils and dynamically by magnetic coils. A homogeneity of the radiation field better than +-5% has been achieved over the diameter of the exit window of 60 mm. The dose rate can be widely adjusted from single particles to more than 10 sup 1 sup 0 particles (i.e. hundreds of Grays) per second. The dose measurement is based on single-particle counting and on standard dosimeters. The detector system for dosimetry and irradiation control is described. In a first radiobiological experiment the cell survival of chinese hamster cells was measured after irradiation with 22.7 MeV protons and compared with the X-ray result.

  16. The potential of proton beam radiation therapy in breast cancer

    International Nuclear Information System (INIS)

    A group of Swedish oncologists and hospital physicists have estimated the number of patients in Sweden suitable for proton beam therapy. The estimations have been based on current statistics of tumour incidence, number of patients potentially eligible for radiation treatment, scientific support from clinical trials and model dose planning studies and knowledge of the dose-response relations of different tumours and normal tissues. In primary breast cancer, it is estimated that about 300 of the annually 3,425 irradiated patients can potentially be candidates for proton beam therapy to reduce late toxicity, mainly from the heart and lungs

  17. A review of radioactive beam facilities in the world

    International Nuclear Information System (INIS)

    Ion beams of radioactive isotopes have been used for over 25 years in studies of the properties of unstable nuclei. Within the past 8 years technological advances have provided the opportunity to produce radioactive beams (RB) with energies and intensities sufficient to perform reactions of interest to nuclear astrophysics, to nuclear structure studies at the extremes, to possibly new paths to heavy element synthesis, to tests of the Standard Model of Electroweak Interactions among the many unique scientific opportunities. Facilities now exist around the world which produce both high energy RB using the PFM (Projectile Fragmentation Method) and low energy RB using the ISOL approach coupled to a post-accelerator. Further, these facilities have also led to renewed interest in the associated technologies including ion source and accelerator developments. In this talk a comparative review and status of RB facilities (proposed, funded and operating) around the world of both production methods will be given with particular emphasis on those utilizing the ISOL approach

  18. Energy verification in Ion Beam Therapy

    CERN Document Server

    Moser, F; Dorda, U

    2011-01-01

    The adoption of synchrotrons for medical applications necessitates a comprehensive on-line verification of all beam parameters, autonomous of common beam monitors. In particular for energy verification, the required precision of down to 0.1MeV in absolute terms, poses a special challenge regarding the betatron-core driven 3rd order extraction mechanism which is intended to be used at MedAustron [1]. Two different energy verification options have been studied and their limiting factors were investigated: 1) A time-of-flight measurement in the synchrotron, limited by the orbit circumference information and measurement duration as well as extraction uncertainties. 2) A calorimeter-style system in the extraction line, limited by radiation hardness and statistical fluctuations. The paper discusses in detail the benefits and specific aspects of each method.

  19. Electron beam therapy of mycosis fungoides

    International Nuclear Information System (INIS)

    Sixteen patients with mycosis fungoides were treated with a 3.3 MeV skin electron beam to a dose of 30 Gy over 40 days. Nine patients achieved a complete remission which was generally short. Only two patients remained free of disease one year following treatment. All patients received palliative benefit from treatment, but no significant increase in survival can be anticipated. (Auth.)

  20. The ITER neutral beam test facility : Design overview

    International Nuclear Information System (INIS)

    In the frame an EFDA contract, the CEA, in close collaboration with the Consorzio RFX, Padua, FZK, Karlsruhe and IPP Garching, is carrying out a design study of the ITER Neutral Beam Test Facility (NBTF) with the aim to procure in time, a dedicated test bed to optimise the performances of the first ITER neutral beam injector and to demonstrate its reliability. The main specifications that have to be considered for the study of the NBTF genetic design and general infrastructure are first an easy maintenance of components, an easy man access and also integration of the required full set of beam diagnostics. A specific inspection tool is developed that allows remote visual inspection of the source ground grid and beam line components to be performed under vacuum. Associated safety requirements are also considered (pulses in H2 and D2, X-ray and neutron production). The current design of the dedicated beam line vessel allows mixed vertical and horizontal access to the beam line components during phase 1 of the operation plan (20s short pulses). The split two halves cylindrical cryopumps, developed by FZK, will be further re-assembled in the final ITER reference cylindrical configuration for phase 2 of the operation plan: long pulses at full power. The 4.5 K cryopanels must be periodically regenerated at 90 K. Both regeneration and cool-down phases of the cryopanels are time consuming optimised. The cryosystem that supply the necessary cryogens to the cryopump is designed using existing industrial 4.5 K cold power and 80 K helium gas refrigenerators. A total power of about 50 MW will have to be removed during the two NBTF operation stages of short (20 s) and long (∼ 1 hour) pulses. for both scenarios, the cooling plant is designed for cooling down the high and low voltage components, the cryoplant and associated power supply systems. (author)

  1. Modeling and optimization of existing beam port facility of PSBR

    International Nuclear Information System (INIS)

    Due to inherited design issues with the current arrangement of beam ports (BPs) and reactor core-moderator assembly in The Perm State Breazeale Reactor (PSBR), the development of innovative experimental facilities utilizing neutron beams is extremely limited. Therefore, a study has started to examine the existing BPs for neutron and gamma outputs and develop a new core-moderator location and BP geometry in PSBR. Although 7 BPs are placed in PSBR, 2 of them are using currently. In this study BP 4, one of the currently being used BP, is examined. With changing the location of the BP 4 and structure of the core assembly, some artificial models are developed and compared with the original model

  2. On-line neutron beam monitoring of the Finnish BNCT facility

    International Nuclear Information System (INIS)

    A Boron Neutron Capture Therapy (BNCT) facility has been built at the FiR 1 research reactor of VTT Chemical Technology in Espoo, Finland. The facility is currently undergoing dosimetry characterisation and neutron beam operation research for clinical trials. The healthy tissue tolerance study, which was carried out in the new facility during spring 1998, demonstrated the reliability and user-friendliness of the new on-line beam monitoring system designed and constructed for BNCT by VTT Chemical Technology. The epithermal neutron beam is monitored at a bismuth gamma shield after an aluminiumfluoride-aluminium moderator. The detectors are three pulse mode U235-fission chambers for epithermal neutron fluence rate and one current mode ionisation chamber for gamma dose rate. By using different detector sensitivities the beam intensity can be measured over a wide range of reactor power levels (0.001-250 kW). The detector signals are monitored on-line with a virtual instrumentation (LabView) based PC-program, which records and displays the actual count rates and total counts of the detectors in the beam. Also reactor in-core power instrumentation and control rod positions can be monitored via another LabView application. The main purpose of the monitoring system is to provide a dosimetric link to the dose in a patient during the treatment, as the fission chamber count rates have been calibrated to the induced thermal neutron fluence rate and to the absorbed dose rate at reference conditions in a tissue substitute phantom

  3. On-line neutron beam monitoring of the Finnish BNCT facility

    Science.gov (United States)

    Tanner, Vesa; Auterinen, Iiro; Helin, Jori; Kosunen, Antti; Savolainen, Sauli

    1999-02-01

    A Boron Neutron Capture Therapy (BNCT) facility has been built at the FiR 1 research reactor of VTT Chemical Technology in Espoo, Finland. The facility is currently undergoing dosimetry characterisation and neutron beam operation research for clinical trials. The healthy tissue tolerance study, which was carried out in the new facility during spring 1998, demonstrated the reliability and user-friendliness of the new on-line beam monitoring system designed and constructed for BNCT by VTT Chemical Technology. The epithermal neutron beam is monitored at a bismuth gamma shield after an aluminiumfluoride-aluminium moderator. The detectors are three pulse mode U 235-fission chambers for epithermal neutron fluence rate and one current mode ionisation chamber for gamma dose rate. By using different detector sensitivities the beam intensity can be measured over a wide range of reactor power levels (0.001-250 kW). The detector signals are monitored on-line with a virtual instrumentation (LabView) based PC-program, which records and displays the actual count rates and total counts of the detectors in the beam. Also reactor in-core power instrumentation and control rod positions can be monitored via another LabView application. The main purpose of the monitoring system is to provide a dosimetric link to the dose in a patient during the treatment, as the fission chamber count rates have been calibrated to the induced thermal neutron fluence rate and to the absorbed dose rate at reference conditions in a tissue substitute phantom.

  4. Development of an external beam facility for PIXE at RMIT

    International Nuclear Information System (INIS)

    An external Proton Induced X-Ray Emission (PIXE) facility for the 1 MV Tandetron accelerator based at Royal Melbourne Institute of Technology has been developed. The 0.35 mm diameter focused beam of 1.6 MeV protons reaches the target after traversing 8 μm Kapton foil coated with gold and 13.5 mm of air. For quantitative analysis, the number of protons hitting the target was determined by the number of backscattered protons from the inner layer of gold on the window foil. Radiation damage causes the Kapton window to exhibit increasing inward diffusion of air. This provides an excellent mechanism for determining the need to replace the window foil before it ruptures. The facility has been used to make non-destructive measurements of the composition of samples from the Museum of Victoria

  5. Beam dynamics simulations and measurements at the Project X Test Facility

    International Nuclear Information System (INIS)

    Project X, under study at Fermilab, is a multitask high-power superconducting RF proton beam facility, aiming to provide high intensity protons for rare processes experiments and nuclear physics at low energy, and simultaneously for the production of neutrinos, as well as muon beams in the long term. A beam test facility - former known as High Intensity Neutrino Source (HINS) - is under commissioning for testing critical components of the project, e.g. dynamics and diagnostics at low beam energies, broadband beam chopping, RF power generation and distribution. In this paper we describe the layout of the test facility and present beam dynamics simulations and measurements.

  6. Beam dynamics simulations and measurements at the Project X Test Facility

    Energy Technology Data Exchange (ETDEWEB)

    Gianfelice-Wendt, E.; Scarpine, V.E.; Webber, R.C.; /Fermilab

    2011-03-01

    Project X, under study at Fermilab, is a multitask high-power superconducting RF proton beam facility, aiming to provide high intensity protons for rare processes experiments and nuclear physics at low energy, and simultaneously for the production of neutrinos, as well as muon beams in the long term. A beam test facility - former known as High Intensity Neutrino Source (HINS) - is under commissioning for testing critical components of the project, e.g. dynamics and diagnostics at low beam energies, broadband beam chopping, RF power generation and distribution. In this paper we describe the layout of the test facility and present beam dynamics simulations and measurements.

  7. The Cornell University cold neutron beam facility: Design features

    International Nuclear Information System (INIS)

    An ultra-low-background facility for basic and applied neutron beam research is being built at the Cornell 500-kW TRIGA reactor. The beam is to be obtained by a curved 13-m neutron guide to filter out fast neutrons and gamma rays from the core, with the neutrons entering the 2-cm by 5-cm guide coming from a cold neutron source of mesitylene at ∼40K to increase transmission through the guide. Optimization of the cold source, within the limits set by design criteria and geometrical restrictions, has involved Monte Carlo simulations to choose source shape and size, and measurements and estimation of nuclear heating and shielding requirements have been made. The design criteria, which include considerations of simplicity and safety of cold source operation at a medium-power reactor on a university campus, are described. Results to date of design studies and low-power trials are presented. Final design choices are imminent and completion of the facility is anticipated for early fall 1990

  8. Metrology and quality of radiation therapy dosimetry of electron, photon and epithermal neutron beams

    International Nuclear Information System (INIS)

    In radiation therapy using electron and photon beams the dosimetry chain consists of several sequential phases starting by the realisation of the dose quantity in the Primary Standard Dosimetry Laboratory and ending to the calculation of the dose to a patient. A similar procedure can be described for the dosimetry of epithermal neutron beams in boron neutron capture therapy (BNCT). To achieve the required accuracy of the dose delivered to a patient the quality of all steps in the dosimetry procedure has to be considered. This work is focused on two items in the dosimetry chains: the determination of the dose in the reference conditions and the evaluation of the accuracy of dose calculation methods. The issues investigated and discussed in detail are: a)the calibration methods of plane parallel ionisation chambers used in electron beam dosimetry, (b) the specification of the critical dosimetric parameter i.e. the ratio of stopping powers for water to air, (S I ?)waterair, in photon beams, (c) the feasibility of the twin ionization chamber technique for dosimetry in epithermal neutron beams applied to BNCT and (d) the determination accuracy of the calculated dose distributions in phantoms in electron, photon, and epithermal neutron beams. The results demonstrate that up to a 3% improvement in the consistency of dose determinations in electron beams is achieved by the calibration of plane parallel ionisation chambers in high energy electron beams instead of calibrations in 60Co gamma beams. In photon beam dosimetry (S I ?)waterair can be determined with an accuracy of 0.2% using the percentage dose at the 10 cm depth, %dd(10), as a beam specifier. The use of %odd(10) requires the elimination of the electron contamination in the photon beam. By a twin ionisation chamber technique the gamma dose can be determined with uncertainty of 6% (1 standard deviation) and the total neutron dose with an uncertainty of 15 to 20% (1 standard deviation). To improve the accuracy of

  9. Metrology and quality of radiation therapy dosimetry of electron, photon and epithermal neutron beams

    Energy Technology Data Exchange (ETDEWEB)

    Kosunen, A

    1999-08-01

    In radiation therapy using electron and photon beams the dosimetry chain consists of several sequential phases starting by the realisation of the dose quantity in the Primary Standard Dosimetry Laboratory and ending to the calculation of the dose to a patient. A similar procedure can be described for the dosimetry of epithermal neutron beams in boron neutron capture therapy (BNCT). To achieve the required accuracy of the dose delivered to a patient the quality of all steps in the dosimetry procedure has to be considered. This work is focused on two items in the dosimetry chains: the determination of the dose in the reference conditions and the evaluation of the accuracy of dose calculation methods. The issues investigated and discussed in detail are: a)the calibration methods of plane parallel ionisation chambers used in electron beam dosimetry, (b) the specification of the critical dosimetric parameter i.e. the ratio of stopping powers for water to air, (S I ?){sup water} {sub air}, in photon beams, (c) the feasibility of the twin ionization chamber technique for dosimetry in epithermal neutron beams applied to BNCT and (d) the determination accuracy of the calculated dose distributions in phantoms in electron, photon, and epithermal neutron beams. The results demonstrate that up to a 3% improvement in the consistency of dose determinations in electron beams is achieved by the calibration of plane parallel ionisation chambers in high energy electron beams instead of calibrations in {sup 60}Co gamma beams. In photon beam dosimetry (S I ?){sup water} {sub air} can be determined with an accuracy of 0.2% using the percentage dose at the 10 cm depth, %dd(10), as a beam specifier. The use of %odd(10) requires the elimination of the electron contamination in the photon beam. By a twin ionisation chamber technique the gamma dose can be determined with uncertainty of 6% (1 standard deviation) and the total neutron dose with an uncertainty of 15 to 20% (1 standard deviation

  10. Preparation of pediatric patients for treatment with proton beam therapy

    International Nuclear Information System (INIS)

    Purpose: Anesthesia is often used in proton beam therapy (PBT) for pediatric patients and this may prolong the treatment time. The aim of the study was to examine preparation of pediatric patients to allow smooth performance of PBT. Material and methods: Preparation was initiated 1–2 days before treatment planning CT and continued for 10 days. The patient first visited the facility to become familiar with the treatment room and staff. As the second step, the patient stayed in the treatment bed for a certain time with their mother, and then stayed on the treatment bed alone. Special fixtures painted with characters, music, and gifts were also prepared. Results: From 2010 to 2014, 111 pediatric patients underwent PBT. These patients were divided into 3 groups: 40 who could follow instructions well (group A, median age: 13.6 years old), 60 who could communicate, but found it difficult to stay alone for a long time (group B, median age: 4.6 years old), and 11 who could not follow instructions (group C, median age: 1.6 years old). Preparation was used for patients in group B. The mean treatment times in groups A, B and C were 13.6, 17.1, and 15.6 min, respectively, on PBT treatment days 2–6, and 11.8, 13.0, and 16.9 min, respectively, for the last 5 days of PBT treatment. The time reduction was significant in group B (p = 0.003). Conclusion: Preparation is useful for pediatric patients who can communicate. This approach allows PBT to be conducted more smoothly over a shorter treatment time

  11. Environmental assessment: Continuous Electron Beam Accelerator Facility, Newport News, Virginia

    International Nuclear Information System (INIS)

    This Environmental Assessment has been prepared by the US Department of Energy (DOE) to fulfill its obligations pursuant to Sect. 102 of the National Environmental Policy Act (NEPA) of 1969 (Public Law 91-190). The proposed federal action addressed in this document is DOE's funding of a Continuous Electron Beam Accelerator Facility (CEBAF) at Newport News, Virginia. DOE intends to contract with the Southeastern Universities Research Association (SURA) for operation of CEBAF, a continuous wave (CW) linear accelerator system (linac) capable of providing high-duty-factor beams throughout the energy range from 0.5 to 4.0 GeV. CEBAF will be the first of its kind worldwide and will offer a multi-GeV energy, high-intensity, high-duty-factor electron beam for use by the US nuclear physics community in research on the states of nuclear matter and the short-distance behavior of nuclei. The CEBAF project is largely in the conceptual design stage, with some components in the preliminary design stage. Construction is anticipated to begin in 1987 and be completed by 1992

  12. Radiation Shielding Analysis of Electron Beam Accelerator Facility

    International Nuclear Information System (INIS)

    The objective of this technical report are to establish the radiation shielding technology of a high-energy electron accelerator to the facilities which utilize with electron beam. The technologies of electron beam irradiation(300 KeV -10 MeV) demand on the diverse areas of material processing, surface treatment, treatments on foods or food processing, improvement of metal properties, semiconductors, and ceramics, sterilization of medical goods and equipment, treatment and control of contamination and pollution, and so on. In order to acquire safety design for the protection of personnel from the radiations produced by electron beam accelerators, it is important to develop the radiation shielding analysis technology. The shielding analysis are carried out by which define source term, calculation modelling and computer calculations for 2 MeV and 10 MeV accelerators. And the shielding analysis for irradiation dump shield with 10 MeV accelerators are also performed by solving the complex 3-D geometry and long computer run time problem. The technology development of shielding analysis will be contributed to extend the further high energy accelerator development

  13. Investigation of plasma–surface interaction at plasma beam facilities

    Energy Technology Data Exchange (ETDEWEB)

    Kurnaev, V., E-mail: kurnaev@plasma.mephi.ru [National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Kashirskoe sh. 31, 115409 Moscow (Russian Federation); Vizgalov, I.; Gutorov, K. [National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Kashirskoe sh. 31, 115409 Moscow (Russian Federation); Tulenbergenov, T.; Sokolov, I.; Kolodeshnikov, A.; Ignashev, V.; Zuev, V.; Bogomolova, I. [Institute of Atomic Energy, National Nuclear Center the Republic of Kazakhstan, Street Krasnoarmejsky, 10, 071100 Kurchatov (Kazakhstan); Klimov, N. [SRC RF TRINITI, ul. Pushkovykh, vladenie 12, Troitsk, 142190 Moscow (Russian Federation)

    2015-08-15

    The new Plasma Beam Facility (PBF) has been put into operation for assistance in testing of plasma faced components at Material Science Kazakhstan Tokamak (KTM). PBF includes a powerful electron gun (up to 30 kV, 1 A) and a high vacuum chamber with longitudinal magnetic field coils (up to 0.2 T). The regime of high vacuum electron beam transportation is used for thermal tests with power density at the target surface up to 10 GW/m{sup 2}. The beam plasma discharge (BPD) regime with a gas-puff is used for generation of intensive ion fluxes up to 3 ⋅ 10{sup 22} m{sup −2} s{sup −1}. Initial tests of the KTM PBF’s capabilities were carried out: various discharge regimes, carbon deposits cleaning, simultaneous thermal and ion impacts on radiation cooled refractory targets. With a water-cooled target the KTM PBF could be used for high heat flux tests of materials (validated by the experiment with W mock-up at the PR-2 PBF)

  14. Development of the RRR cold neutron beam facility

    International Nuclear Information System (INIS)

    This paper describes some general design issues on the neutron beam facilities (cold neutron source and neutron beam transport system) of the Replacement Research Reactor (RRR) for the Australian Nuclear Science and Technology Organisation (ANSTO). The description covers different aspect of the design: the requirements that lead to an innovative design, the overall design itself, the definition of a technical approach in order to develop the necessary design solutions, and finally the organizational framework by which international expertise from five different institutions is integrated. From the technical viewpoint, the RRR-CNS is a liquid Deuterium (LD2) moderator, sub-cooled to ensure maximum moderation efficiency, flowing within a closed natural circulation thermosyphon loop. The thermosyphon is surrounded by a zirconium alloy CNS vacuum containment that provides thermal insulation and a multiple barriers scheme to prevent Deuterium from mixing with water or air. Consistent with international practice, this vessel is designed to withstand any hypothetical energy reaction should Deuterium and air mix in its interior. The 'cold' neutrons are then taken by the NBTS and transported by the neutron guide system into the reactor beam hall and neutron guide hall, where neutron scattering instruments are located. From the management viewpoint, the adopted distributed scheme is successful to manage the complex interfacing between highly specialized technologies, allowing a smooth integration within the project. (author)

  15. Tritium Monitoring in the ITER Neutral Beam Test Facility

    International Nuclear Information System (INIS)

    The proposed ITER Neutral Beam Test Facility (NBTF) is designed to operate with negative ion neutral injectors in order to provide the required beam power and efficiency. The operation of the neutral beam test bed involves the firing of a beam of deuterons into a calorimeter. The deuterons will become embedded in the calorimeter and subsequent particles can be involved in deuterium fusion reactions. There are two branches of this reaction which have approximately equal probability. These are: D + D → 3He + n D + D → 3H + p Because of this relationship, it is possible to estimate the level of tritium production accurately by measuring the neutron production. The proposed testing campaign will generate an annual tritium discharge to the atmosphere of about 246 GBq. An absolutely calibrated neutron monitor is needed for tritium accounting but difficulties arise because the neutron source is complex: it is spatially extended and varying and is anisotropic. Furthermore the material of the injector will cause significant scattering of neutrons between the source and any detector. To resolve these problems it is proposed that a set of detectors is deployed around the injector and that a neutron source be placed within the injector is used to calibrate them. Very detailed Monte-Carlo calculations have been carried out to model the neutron transport thought the NBTF. All major component of the injector have been modelled. These include the calorimeter, the residual ion dump, the neutraliser, the beam source, the HV bushing and the vacuum vessel. The spatial variation of the neutron source, based on the deuteron deposition on the calorimeter and the residual ion dump has been simulated. The effects of anisotropy and the angular dependence of the neutron energy spectrum have been included. The calculations demonstrate that such a suite of detectors can be calibrated using a 252Cf source to absolutely determine the neutron and therefore the tritium production to an

  16. Optimal Neutron Source and Beam Shaping Assembly for Boron Neutron Capture Therapy

    International Nuclear Information System (INIS)

    There were three objectives to this project: (1) The development of the 2-D Swan code for the optimization of the nuclear design of facilities for medical applications of radiation, radiation shields, blankets of accelerator-driven systems, fusion facilities, etc. (2) Identification of the maximum beam quality that can be obtained for Boron Neutron Capture Therapy (BNCT) from different reactor-, and accelerator-based neutron sources. The optimal beam-shaping assembly (BSA) design for each neutron source was also to e obtained. (3) Feasibility assessment of a new neutron source for NCT and other medical and industrial applications. This source consists of a state-of-the-art proton or deuteron accelerator driving and inherently safe, proliferation resistant, small subcritical fission assembly

  17. Optimal Neutron Source and Beam Shaping Assembly for Boron Neutron Capture Therapy

    CERN Document Server

    Vujic, J L; Greenspan, E; Guess, S; Karni, Y; Kastenber, W E; Kim, L; Leung, K N; Regev, D; Verbeke, J M; Waldron, W L; Zhu, Y

    2003-01-01

    There were three objectives to this project: (1) The development of the 2-D Swan code for the optimization of the nuclear design of facilities for medical applications of radiation, radiation shields, blankets of accelerator-driven systems, fusion facilities, etc. (2) Identification of the maximum beam quality that can be obtained for Boron Neutron Capture Therapy (BNCT) from different reactor-, and accelerator-based neutron sources. The optimal beam-shaping assembly (BSA) design for each neutron source was also to e obtained. (3) Feasibility assessment of a new neutron source for NCT and other medical and industrial applications. This source consists of a state-of-the-art proton or deuteron accelerator driving and inherently safe, proliferation resistant, small subcritical fission assembly.

  18. Optimal Neutron Source & Beam Shaping Assembly for Boron Neutron Capture Therapy

    Energy Technology Data Exchange (ETDEWEB)

    J. Vujic; E. Greenspan; W.E. Kastenber; Y. Karni; D. Regev; J.M. Verbeke, K.N. Leung; D. Chivers; S. Guess; L. Kim; W. Waldron; Y. Zhu

    2003-04-30

    There were three objectives to this project: (1) The development of the 2-D Swan code for the optimization of the nuclear design of facilities for medical applications of radiation, radiation shields, blankets of accelerator-driven systems, fusion facilities, etc. (2) Identification of the maximum beam quality that can be obtained for Boron Neutron Capture Therapy (BNCT) from different reactor-, and accelerator-based neutron sources. The optimal beam-shaping assembly (BSA) design for each neutron source was also to e obtained. (3) Feasibility assessment of a new neutron source for NCT and other medical and industrial applications. This source consists of a state-of-the-art proton or deuteron accelerator driving and inherently safe, proliferation resistant, small subcritical fission assembly.

  19. A Monte Carlo code for ion beam therapy

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    Initially developed for applications in detector and accelerator physics, the modern Fluka Monte Carlo code is now used in many different areas of nuclear science. Over the last 25 years, the code has evolved to include new features, such as ion beam simulations. Given the growing use of these beams in cancer treatment, Fluka simulations are being used to design treatment plans in several hadron-therapy centres in Europe.   Fluka calculates the dose distribution for a patient treated at CNAO with proton beams. The colour-bar displays the normalized dose values. Fluka is a Monte Carlo code that very accurately simulates electromagnetic and nuclear interactions in matter. In the 1990s, in collaboration with NASA, the code was developed to predict potential radiation hazards received by space crews during possible future trips to Mars. Over the years, it has become the standard tool to investigate beam-machine interactions, radiation damage and radioprotection issues in the CERN accelerator com...

  20. Optimization of the irradiation beam in the BNCT research facility at IEA-R1 reactor

    International Nuclear Information System (INIS)

    Boron Neutron Capture Therapy (BNCT) is a radiotherapeutic technique for the treatment of some types of cancer whose useful energy comes from a nuclear reaction that occurs when thermal neutron impinges upon a Boron-10 atom. In Brazil there is a research facility built along the beam hole number 3 of the IEA-R1 research reactor at IPEN, which was designed to perform BNCT research experiments. For a good performance of the technique, the irradiation beam should be mostly composed of thermal neutrons with a minimum as possible gamma and above thermal neutron components. This work aims to monitor and evaluate the irradiation beam on the sample irradiation position through the use of activation detectors (activation foils) and also to propose, through simulation using the radiation transport code, MCNP, new sets of moderators and filters which shall deliver better irradiation fields at the irradiation sample position In this work, a simulation methodology, based on a MCNP card, known as wwg (weight window generation) was studied, and the neutron energy spectrum has been experimentally discriminated at 5 energy ranges by using a new set o activation foils. It also has been concluded that the BNCT research facility has the required thermal neutron flux to perform studies in the area and it has a great potential for improvement for tailoring the irradiation field. (author)

  1. Individual patient shielding for a proton eye therapy facility

    International Nuclear Information System (INIS)

    The first proton ocular radiotherapy facility in Poland has been developed at the Institute of Nuclear Physics (IFJ PAN), Krakow, in collaboration with the Clinic of Ophthalmology and Ocular Oncology of the Collegium Medicum of the Jagiellonian University in Krakow and the Centre of Oncology of the Maria Sklodowska-Curie Memorial Institute Krakow Branch. For the proton beam from the AIC-144 isochronous cyclotron the unwanted patient dose due to secondary radiation - predominantly neutrons - has been evaluated using the MCNPX code. Optimisation of the beam forming elements and designing of the additional patient shielding has been performed to minimize the unwanted patient's dose.

  2. Proton beam therapy how protons are revolutionizing cancer treatment

    CERN Document Server

    Yajnik, Santosh

    2013-01-01

    Proton beam therapy is an emerging technology with promise of revolutionizing the treatment of cancer. While nearly half of all patients diagnosed with cancer in the US receive radiation therapy, the majority is delivered via electron accelerators, where photons are used to irradiate cancerous tissue. Because of the physical properties of photon beams, photons may deposit energy along their entire path length through the body. On the other hand, a proton beam directed at a tumor travels in a straight trajectory towards its target, gives off most of its energy at a defined depth called the Bragg peak, and then stops. While photons often deposit more energy within the healthy tissues of the body than within the cancer itself, protons can deposit most of their cancer-killing energy within the area of the tumor. As a result, in the properly selected patients, proton beam therapy has the ability to improve cure rates by increasing the dose delivered to the tumor and simultaneously reduce side-effects by decreasing...

  3. Clinical results of proton beam therapy for skull base chordoma

    International Nuclear Information System (INIS)

    Purpose: To evaluate clinical results of proton beam therapy for patients with skull base chordoma. Methods and materials: Thirteen patients with skull base chordoma who were treated with proton beams with or without X-rays at the University of Tsukuba between 1989 and 2000 were retrospectively reviewed. A median total tumor dose of 72.0 Gy (range, 63.0-95.0 Gy) was delivered. The patients were followed for a median period of 69.3 months (range, 14.6-123.4 months). Results: The 5-year local control rate was 46.0%. Cause-specific, overall, and disease-free survival rates at 5 years were 72.2%, 66.7%, and 42.2%, respectively. The local control rate was higher, without statistical significance, for those with preoperative tumors <30 mL. Partial or subtotal tumor removal did not yield better local control rates than for patients who underwent biopsy only as the latest surgery. Conclusion: Proton beam therapy is effective for patients with skull base chordoma, especially for those with small tumors. For a patient with a tumor of <30 mL with no prior treatment, biopsy without tumor removal seems to be appropriate before proton beam therapy

  4. Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy.

    Science.gov (United States)

    Allen, Christopher; Borak, Thomas B; Tsujii, Hirohiko; Nickoloff, Jac A

    2011-06-01

    Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilities, particle therapy has shown improved cancer survival rates, reflecting more highly focused dose distributions and more severe DNA damage to tumor cells. Despite early successes of charged particle radiotherapy, there is room for further improvement, and much remains to be learned about normal and cancer cell responses to charged particle radiation. PMID:21376738

  5. Radiation quality and ion-beam therapy: understanding the users' needs

    International Nuclear Information System (INIS)

    Ion-beam therapy faces a growing demand of tools able to map radiation quality within the irradiated volume. Although analytical computations and simulations provide useful estimations of dose and radiation quality, the direct measure of those parameters would improve ion-beam therapy in particular when deep-seated tumours are irradiated, tissue composition and density are variable or organs at risk are near the tumour. Several ion-beam therapy facilities are studying detectors and procedures for measuring the radiation quality on a microdosimetric as well as a nanodosimetric scale. Simplicity and miniaturisation of the devices are essential for measurements first in phantoms and thereafter during therapy, particularly for intra-cavity detectors. MedAustron is studying solid-state detectors based on a single crystal chemical vapour deposition diamond. In collaboration with Italian National Institute for Nuclear Physics (INFN), Tor Vergata and Legnaro; INFN-microdosimetry and track structure project; Austrian Institute of Technology, Vienna; and Italian National agency for new technologies, energy and sustainable economic development, Rome, prototypes have been developed to characterise radiation quality in sizes equivalent to one micrometre of biological tissue. (authors)

  6. Beam intensity and dose monitor system for heavy-ion tumor therapy

    International Nuclear Information System (INIS)

    The clinical trials of tumor therapy using heavy ion beams, supplied by the cooler storage ring of the Heavy Ion Research Facility in Lanzhou (HIRFL-CSR) with the energy of 100 to 450 MeV/u, are now in progress at the Institute of Modern Physics in Lanzhou. A beam intensity and dose monitor system has been developed to real-time monitor the irradiation dose and beam intensity stability and to make sure the safety of the patients. It is composed of integral ionization chamber, current-frequency transfer electric board and LabVIEW data acquiring and analyzing system. The measurements of this system show that it can work well under the clinical condition. (authors)

  7. Nano-scale processes behind ion-beam cancer therapy

    Science.gov (United States)

    Surdutovich, Eugene; Garcia, Gustavo; Mason, Nigel; Solov'yov, Andrey V.

    2016-04-01

    This topical issue collates a series of papers based on new data reported at the third Nano-IBCT Conference of the COST Action MP1002: Nanoscale Insights into Ion Beam Cancer Therapy, held in Boppard, Germany, from October 27th to October 31st, 2014. The Nano-IBCT COST Action was launched in December 2010 and brought together more than 300 experts from different disciplines (physics, chemistry, biology) with specialists in radiation damage of biological matter from hadron-therapy centres, and medical institutions. This meeting followed the first and the second conferences of the Action held in October 2011 in Caen, France and in May 2013 in Sopot, Poland respectively. This conference series provided a focus for the European research community and has highlighted the pioneering research into the fundamental processes underpinning ion beam cancer therapy. Contribution to the Topical Issue "COST Action Nano-IBCT: Nano-scale Processes Behind Ion-Beam Cancer Therapy", edited by Andrey V. Solov'yov, Nigel Mason, Gustavo Garcia and Eugene Surdutovich.

  8. Status of the realization of the neutral beam test facility

    International Nuclear Information System (INIS)

    The ITER Neutral Beam Injectors (NBI) are required to deliver 16.5 MW of additional heating power to the plasma, accelerating negative ions up to -1 MV with a beam current of 40A lasting up to 1 hour. Since these outstanding requirements were never achieved all together so far, the realization of a Neutral Beam Test Facility (NBTF), called PRIMA, currently under construction in Padova, was launched with the aim to test the operation of the NB injector and to study the relevant physical and technological issues, in advance to the implementation in ITER. Two projects are under development: MITICA and SPIDER. MITICA is a full scale prototype of the ITER NB injector; the design is based on a similar scheme and layout, with the same power supply system and also the control and protection systems are being designed according to the ITER rules and constraints. The HV components are procured by JADA; the low voltage ones and the injector are procured by F4E. SPIDER project is an ion source with the same characteristics of the ITER one, specifically addressed to study the issues related to the RF operation; for this reason, the beam energy is limited to 100keV. It can generate both Hydrogen and Deuterium Ions; the design includes provisions to filter electrons and also to allow the use of cesium to attain the high values of current density required. SPIDER is procured by F4E and INDA. The construction of PRIMA buildings and auxiliaries, started in autumn 2008, was completed in summer 2015. SPIDER plant systems procurement is well advanced and some systems are under installation or site acceptance tests. In 2016 integrated commissioning and power supply integrated tests will be performed followed by the beginning of the first experimental phase. MITICA design was completed; many procurement contracts have been signed or will be launched in the next months. Installation activity will start in December 2015 with the installation of the first HV power supply components provided

  9. Development of beam instruments at JAERI cyclotron facility

    Energy Technology Data Exchange (ETDEWEB)

    Okumura, Susumu; Fukuda, Mitsuhiro; Ishibori, Ikuo; Agematsu, Takashi; Yokota, Watalu; Nara, Takayuki; Nakamura, Yoshiteru; Arakawa, Kazuo [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    1997-03-01

    A beam phase monitor and two kinds of fluence distribution monitors have been developed for measuring characteristics of cyclotron beams. The beam phase monitor provides a beam phase signal for tuning a beam chopping system and a beam phase selection system. A two-dimensional fluence distribution on a large area is measured with fluence distribution monitors. (author)

  10. Performance of MACACO Compton telescope for ion-beam therapy monitoring : first test with proton beams

    NARCIS (Netherlands)

    Solevi, Paola; Munoz, Enrique; Solaz, Carles; Trovato, Marco; Dendooven, Peter; Gillam, John E.; Lacasta, Carlos; Oliver, Josep F.; Rafecas, Magdalena; Torres-Espallardo, Irene; Llosa, Gabriela

    2016-01-01

    In order to exploit the advantages of ion-beam therapy in a clinical setting, delivery verification techniques are necessary to detect deviations from the planned treatment. Efforts are currently oriented towards the development of devices for real-time range monitoring. Among the different detector

  11. ISABELLE: a proton-proton colliding beam facility

    International Nuclear Information System (INIS)

    A proposal is presented for the construction of an Intersecting Storage Accelerator, ISABELLE, to be located at Brookhaven National Laboratory. At this major research facility, colliding beams of protons will be produced and studied by particle physicists. This proposal combines the interests of these particle physicists in exploring a new energy regime with the challenge of building a new research instrument. The proposal results from several years of considering such devices in parallel with extensive developmental work. The proposal is divided into several major parts. Following an introduction is an overall summary of the proposal covering its highlights. Part II contains a thorough discussion of the physics objectives that can be addressed by the storage ring. It begins with an explanation of current theoretical concepts that occupy the curiosity of high energy physicists. Then follows a brief discussion of possible experiments that might be assembled at the interaction regions to test these concepts. The third part of the proposal goes into the details of the design of the intersecting storage accelerators. It begins with a description of the entire facility and the design of the magnet ring structure. The processes of proton beam accumulation and acceleration are thoroughly described. The discussion then turns to the design of the components and subsystems for the accelerator. The accelerator elements are described followed by a description of the physical plant. The cost estimate and time scales are displayed in Part IV. Here the estimate has been based on the experience gained from working with the prototype units at the laboratory. The appendices are an important part of the proposal. The parameter list for the 200 x 200 GeV ISABELLE is carefully documented. An example of a possible research program can be found in an appendix. The performance of prototype units is documented in one of the appendices

  12. A physical palette for ion-beam cancer therapy

    Energy Technology Data Exchange (ETDEWEB)

    Surdutovich, E.; Solov' yov, A.V. [Frankfurt Institute for Advanced Studies, Frankfurt am Main (Germany); Surdutovich, E. [Oakland Univ., Rochester, MI (United States)

    2009-07-01

    Ion-beam cancer therapy and proton-beam therapy have been used successfully. Despite apparent experimental and clinical successes, a comprehensive theoretical description of a physical scenario is missing. One reason is that the phenomena initiated by an energetic ion incident on tissue happen on many scales in time, distance and energy. DNA is disrupted as a result of energy deposition by incident ions, mainly due to the ionization of the medium. The secondary electrons formed in this process are considered to be mostly responsible for DNA damage through either direct breaking of DNA strands, or reacting with water molecules producing more active secondaries, or through the heating of the medium. Our calculations show that the seemingly insurmountable complexity of the geometry of DNA in different states may be overcome, because the geometrical differences are found to be insignificant. (A.C.)

  13. Characterization of a tagged $\\gamma$-ray beam line at the DAFNE Beam Test Facility

    CERN Document Server

    Cattaneo, P W; Boffelli, F; Bulgarelli, A; Buonomo, B; Chen, A W; D’Ammando, F; FoggettA, L; Froysland, T; Fuschino, F; Galli, M; Gianotti, F; Giuliani, A; Longo, F; Marisaldi, M; Mazzitelli, G; Pellizzoni, A; Prest, M; Pucella, G; Quintieri, L; Rappoldi, A; Tavani, M; Trifoglio, M; Trois, A; Valente, P; Vallazza, E; Vercellone, S; Zambra, A; Barbiellini, G; Caraveo, P; Cocco, V; Costa, E; De Paris, G; Del Monte, E; Di Cocco, G; Donnarumma, I; Evangelista, Y; Feroci, M; Ferrari, A; Fiorini, M; Labanti, C; Lapshov, I; Lazzarotto, F; Lipari, P; Mastropietro, M; Mereghetti, S; Morelli, E; Moretti, E; Morselli, A; Pacciani, L; Perotti, F; Piano, G; Picozza, P; Pilia, M; Porrovecchio, G; Rapisarda, M; Rubini, A; Sabatini, S; Soffitta, P; Striani, E; Vittorini, V; Zanello, D; Colafrancesco, S; Giommi, P; Pittori, C; Santolamazza, P; Verrecchia, F; Salotti, L

    2012-01-01

    At the core of the AGILE scientific instrument, designed to operate on a satellite, there is the Gamma Ray Imaging Detector (GRID) consisting of a Silicon Tracker (ST), a Cesium Iodide Mini-Calorimeter and an Anti-Coincidence system of plastic scintillator bars. The ST needs an on-ground calibration with a γ-ray beam to validate the simulation used to calculate the energy response function and the effective area versus the energy and the direction of the γ rays. A tagged γ-ray beam line was designed at the Beam Test Facility (BTF) of the INFN Laboratori Nazionali of Frascati (LNF), based on an electron beam generating γ-rays through bremsstrahlung in a position-sensitive target. The γ-ray energy is deduced by difference with the post-bremsstrahlung electron energy [1] and [2]. The electron energy is measured by a spectrometer consisting of a dipole magnet and an array of position sensitive silicon strip detectors, the Photon Tagging System (PTS). The use of the combined BTF-PTS system as tagged photon be...

  14. Design study of facilities for boron neutron capture therapy

    International Nuclear Information System (INIS)

    One of the authors organized a research group on boron neutron capture therapy (BNCT) during 1975 to 1979. The results of the research were summarized in two Japanese reports. It was concluded in 1976 that a nuclear reactor facility was required for developing BNCT and related research. Conceptual design of the facility was performed according to consultation among the group members, and is reported here. The optimum neutron energy for BNCT is shown to be between 10eV and 500eV

  15. High resolution muon computed tomography at neutrino beam facilities

    International Nuclear Information System (INIS)

    X-ray computed tomography (CT) has an indispensable role in constructing 3D images of objects made from light materials. However, limited by absorption coefficients, X-rays cannot deeply penetrate materials such as copper and lead. Here we show via simulation that muon beams can provide high resolution tomographic images of dense objects and of structures within the interior of dense objects. The effects of resolution broadening from multiple scattering diminish with increasing muon momentum. As the momentum of the muon increases, the contrast of the image goes down and therefore requires higher resolution in the muon spectrometer to resolve the image. The variance of the measured muon momentum reaches a minimum and then increases with increasing muon momentum. The impact of the increase in variance is to require a higher integrated muon flux to reduce fluctuations. The flux requirements and level of contrast needed for high resolution muon computed tomography are well matched to the muons produced in the pion decay pipe at a neutrino beam facility and what can be achieved for momentum resolution in a muon spectrometer. Such an imaging system can be applied in archaeology, art history, engineering, material identification and whenever there is a need to image inside a transportable object constructed of dense materials

  16. Proton beam therapy for locally advanced lung cancer: A review

    OpenAIRE

    Schild, Steven E.; Rule, William G; Ashman, Jonathan B; Vora, Sujay A; Keole, Sameer; Anand, Aman; Liu, Wei; Bues, Martin

    2014-01-01

    Protons interact with human tissue differently than do photons and these differences can be exploited in an attempt to improve the care of lung cancer patients. This review examines proton beam therapy (PBT) as a component of a combined modality program for locally advanced lung cancers. It was specifically written for the non-radiation oncologist who desires greater understanding of this newer treatment modality. This review describes and compares photon (X-ray) radiotherapy (XRT) to PBT. Th...

  17. Controls and Beam Diagnostics for Therapy-Accelerators

    CERN Document Server

    Eickhoff, H

    2000-01-01

    During the last four years GSI has developed a new procedure for cancer treatment by means of the intensity controlled rasterscan-method. This method includes active variations of beam parameters during the treatment session and the integration of 'on-line' PET monitoring. Starting in 1997 several patients have been successfully treated within this GSI experimental cancer treatment program; within this program about 350 patients shall be treated in the next 5 years. The developments and experiences of this program accompanied by intensive discussions with the medical community led to a proposal for a hospital based light ion accelerator facility for the clinic in Heidelberg. An essential part for patients treatments is the measurement of the beam properties within acceptance and constancy tests and especially for the rasterscan method during the treatment sessions. The presented description of the accelerator controls and beam diagnostic devices mainly covers the requests for the active scanning method, which...

  18. Neutron radiation area monitoring system for proton therapy facilities

    International Nuclear Information System (INIS)

    A neutron radiation area monitoring system has been developed for proton accelerator facilities dedicated to cancer therapy. The system comprises commercial measurement equipment, computer hardware and a suite of software applications that were developed specifically for use in a medical accelerator environment. The system is designed to record and display the neutron dose-equivalent readings from 16 to 24 locations (depending on the size of the proton therapy centre) throughout the facility. Additional software applications provide for convenient data analysis, plotting, radiation protection reporting, and system maintenance and administration tasks. The system performs with a mean time between failures of >6 months. Required data storage capabilities and application execution times are met with inexpensive off-the-shelf computer hardware. (authors)

  19. A Study on the Ion Beam Extraction using Duo-PiGatron Ion source for Vertical Type Ion Beam Facility

    International Nuclear Information System (INIS)

    In Korea Multipurpose Accelerator Complex (KOMAC), we have started ion beam service in the new beam utilization building since March this year. For various ion beam irradiation services, we are developed implanters such as metal (150keV/1mA), gaseous (200keV/5mA) and high current ion beam facility (20keV/150mA). One of the new one is a vertical type ion beam facility without acceleration tube (60keV/20mA) which is easy to install the sample. After the installation is complete, it is where you are studying the optimal ion beam extraction process. Detailed experimental results will be presented. Vertical Type Ion Beam Facility without acceleration tube of 60keV 20mA class was installed. We successfully extracted 60keV 20mA using Duo- PiGatron Ion source for Vertical Type Ion Beam Facility. Use the BPM and Faraday-cup, is being studied the optimum conditions of ion beam extraction

  20. A Study on the Ion Beam Extraction using Duo-PiGatron Ion source for Vertical Type Ion Beam Facility

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bom Sok; Lee, Chan young; Lee, Jae Sang [KAERI, Daejeon (Korea, Republic of)

    2015-05-15

    In Korea Multipurpose Accelerator Complex (KOMAC), we have started ion beam service in the new beam utilization building since March this year. For various ion beam irradiation services, we are developed implanters such as metal (150keV/1mA), gaseous (200keV/5mA) and high current ion beam facility (20keV/150mA). One of the new one is a vertical type ion beam facility without acceleration tube (60keV/20mA) which is easy to install the sample. After the installation is complete, it is where you are studying the optimal ion beam extraction process. Detailed experimental results will be presented. Vertical Type Ion Beam Facility without acceleration tube of 60keV 20mA class was installed. We successfully extracted 60keV 20mA using Duo- PiGatron Ion source for Vertical Type Ion Beam Facility. Use the BPM and Faraday-cup, is being studied the optimum conditions of ion beam extraction.

  1. Beamlines of the biomedical imaging and therapy facility at the Canadian light source-Part 1

    Energy Technology Data Exchange (ETDEWEB)

    Wysokinski, Tomasz W. [Canadian Light Source, Saskatoon, SK (Canada)], E-mail: tomasz.wysokinski@lightsource.ca; Chapman, Dean [Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, SK (Canada); Adams, Gregg [Western College of Veterinary Medicine, Saskatoon, SK (Canada); Renier, Michel [European Synchrotron Radiation Facility, Grenoble (France); Suortti, Pekka [Department of Physical Sciences, University of Helsinki (Finland); Thomlinson, William [Canadian Light Source, Saskatoon, SK (Canada)

    2007-11-11

    The BioMedical Imaging and Therapy (BMIT) Facility will provide synchrotron-specific imaging and therapy capabilities. This paper describes one of the BMIT beamlines: the bend magnet (BM) beamline 05B1-1. It plays a complementary role to the insertion device (ID) beamline 051D-2 and allows either monochromatic or filtered white beam to be used in the experimental hutch. The monochromatic spectral range will span 8-40 keV, and the beam is more than 200 mm wide in the experimental hutch for imaging studies of small and medium-size animals (up to sheep size). The experimental hutch will have a positioning system that will allow imaging (computed tomography and planar imaging) as well as radiation therapy applications with both filtered white and monochromatic X-ray beams and will handle subjects up to 120 kg. Several different focal plane detectors (cameras) will be available with resolutions ranging from 10 to 150 {mu}m.

  2. Experiments and FLUKA simulations of $^{12}C$ and $^{16}O$ beams for therapy monitoring by means of in-beam Positron Emission Tomography

    CERN Document Server

    Sommerer,; Ferrari, A

    2007-01-01

    Since 1997 at the experimental C-12 ion therapy facility at Gesellschaft fuer Schwerionenforschung (GSI), Darmstadt, Germany, more than 350 patients have been treated. The therapy is monitored with a dedicated positron emission tomograph, fully integrated into the treatment site. The measured beta+-activity arises from inelastic nuclear interactions between the beam particles an the nuclei of the patients tissue. Because the monitoring is done during the irradiation the method is called in-beam PET. The underlying principle of this monitoring is a comparison between the measured activity and a simulated one. The simulations are presently done by the PETSIM code which is dedicated to C-12 beams. In future ion therapy centers like the Heidelberger Ionenstrahl Therapiezentrum (HIT), Heidelberg, Germany, besides C-12 also proton, $^3$He and O-16 beams will be used for treatment and the therapy will be monitored by means of in-beam PET. Because PETSIM is not extendable to other ions in an easy way, a code capable ...

  3. Power burst reactor facility as an epithermal neutron source for brain cancer therapy

    International Nuclear Information System (INIS)

    The Power Burst Facility (PBF) reactor is considered for modification to provide an intense, clean source of intermediate-energy (epithermal) neutrons desirable for clinical studies of neutron capture therapy (NCT) for malignant tumors. The modifications include partial replacement of the reflector, installation of a neutron-moderating, shifting region, addition shielding, and penetration of the present concrete shield with a collimating and (optionally) filtering region. The studies have indicated that the reactor, after these modifications, will be safely operable at full power (28 MW) within the acceptable limits of the plant protection systems. The neutron beam existing from the collimator port is predicted to be of sufficient intensity (∼ 1010) neutrons/cm2-s) to provide therapeutic doses in very short irradiation times. The beam would be relatively free of undesirable fast neutrons, thermal neutrons and gamma rays. The calculated neutron energy spectrum and associated gamma rays in the beam were provided as input in simulation studies that used a computer model of a patient with a brain tumor to determine predicted dose rates to the tumor and healthy tissue. The results of this conceptual study indicate an intense, clean beam of epithermal neutrons for NCT clinical trials is attainable in the PBF facility with properly engineered design modifications. 9 references, 11 figures, 3 tables

  4. Establishment of nuclear data system - Feasibility study for neutron-beam= facility at pohang accelerator laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Nam Kung, Won; Koh, In Soo; Cho, Moo Hyun; Kim, Kui Nyun; Kwang, Hung Sik; Park, Sung Joo [Pohang Accelerator Laboratory, Pohang (Korea, Republic of)

    1996-12-01

    Nuclear data which have been produced by a few developed countries in the= past are essential elements to many disciplines, especially to nuclear engineering. As we promote our nuclear industry further to the level of advanced countries, we also have to establish the Nuclear Data System to produce and evaluate nuclear data independently. We have studied the possibility to build a neutron-beam facility utilizing accelerator facilities, technologies and man powers at pohang Accelerator Laboratory. We found specific parameters for the PAL 100-MeV electron linac based on the existing klystron, modulator, accelerating tubes and other facilities in the PAL; the beam energy is 60-100 MeV, the beam current for the short pulse (10 ns) is 2 A and for the long pulse is 500 mA and the pulse repetition rate is 60 Hz. We propose a neutron-beam facility using PAL 100-MeV electron linac where we can use a Ta-target for the neutron generation and three different time-of-flight beam lines (10 m, 20 m, and 100 m). One may find that the proposed neutron-beam facility is comparable with other operating neutron facilities in the world. We conclude that the proposed neutron-beam facility utilizing the existing accelerator facility in the PAL would be an excellent facility for neutron data production in combination with the ` Hanaro` facility in KAERI. 8 refs., 11 tabs., 12 figs. (author)

  5. Accelerator Based Neutron Beams for Neutron Capture Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Yanch, Jacquelyn C.

    2003-04-11

    The DOE-funded accelerator BNCT program at the Massachusetts Institute of Technology has resulted in the only operating accelerator-based epithermal neutron beam facility capable of generating significant dose rates in the world. With five separate beamlines and two different epithermal neutron beam assemblies installed, we are currently capable of treating patients with rheumatoid arthritis in less than 15 minutes (knee joints) or 4 minutes (finger joints) or irradiating patients with shallow brain tumors to a healthy tissue dose of 12.6 Gy in 3.6 hours. The accelerator, designed by Newton scientific Incorporated, is located in dedicated laboratory space that MIT renovated specifically for this project. The Laboratory for Accelerator Beam Applications consists of an accelerator room, a control room, a shielded radiation vault, and additional laboratory space nearby. In addition to the design, construction and characterization of the tandem electrostatic accelerator, this program also resulted in other significant accomplishments. Assemblies for generating epithermal neutron beams were designed, constructed and experimentally evaluated using mixed-field dosimetry techniques. Strategies for target construction and target cooling were implemented and tested. We demonstrated that the method of submerged jet impingement using water as the coolant is capable of handling power densities of up to 6 x 10(sup 7) W/m(sup 2) with heat transfer coefficients of 10(sup 6)W/m(sup 2)-K. Experiments with the liquid metal gallium demonstrated its superiority compared with water with little effect on the neutronic properties of the epithermal beam. Monoenergetic proton beams generated using the accelerator were used to evaluate proton RBE as a function of LET and demonstrated a maximum RBE at approximately 30-40 keV/um, a finding consistent with results published by other researchers. We also developed an experimental approach to biological intercomparison of epithermal beams and

  6. Accelerator Based Neutron Beams for Neutron Capture Therapy

    International Nuclear Information System (INIS)

    The DOE-funded accelerator BNCT program at the Massachusetts Institute of Technology has resulted in the only operating accelerator-based epithermal neutron beam facility capable of generating significant dose rates in the world. With five separate beamlines and two different epithermal neutron beam assemblies installed, we are currently capable of treating patients with rheumatoid arthritis in less than 15 minutes (knee joints) or 4 minutes (finger joints) or irradiating patients with shallow brain tumors to a healthy tissue dose of 12.6 Gy in 3.6 hours. The accelerator, designed by Newton scientific Incorporated, is located in dedicated laboratory space that MIT renovated specifically for this project. The Laboratory for Accelerator Beam Applications consists of an accelerator room, a control room, a shielded radiation vault, and additional laboratory space nearby. In addition to the design, construction and characterization of the tandem electrostatic accelerator, this program also resulted in other significant accomplishments. Assemblies for generating epithermal neutron beams were designed, constructed and experimentally evaluated using mixed-field dosimetry techniques. Strategies for target construction and target cooling were implemented and tested. We demonstrated that the method of submerged jet impingement using water as the coolant is capable of handling power densities of up to 6 x 10(sup 7) W/m(sup 2) with heat transfer coefficients of 10(sup 6)W/m(sup 2)-K. Experiments with the liquid metal gallium demonstrated its superiority compared with water with little effect on the neutronic properties of the epithermal beam. Monoenergetic proton beams generated using the accelerator were used to evaluate proton RBE as a function of LET and demonstrated a maximum RBE at approximately 30-40 keV/um, a finding consistent with results published by other researchers. We also developed an experimental approach to biological intercomparison of epithermal beams and

  7. Particle Beam Therapy for Cancer of the Skull Base, Nasal Cavity, and Paranasal Sinus

    OpenAIRE

    Fukumitsu, Nobuyoshi

    2012-01-01

    Particle beam therapy has been rapidly developed in these several decades. Proton and carbon ion beams are most frequently used in particle beam therapy. Proton and carbon ion beam radiotherapy have physical and biological advantage to the conventional photon radiotherapy. Cancers of the skull base, nasal cavity, and paranasal sinus are rare; however these diseases can receive the benefits of particle beam radiotherapy. This paper describes the clinical review of the cancer of the skull base,...

  8. Pitfalls of tungsten multileaf collimator in proton beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Moskvin, Vadim; Cheng, Chee-Wai; Das, Indra J. [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202 (United States) and Indiana University Health Proton Therapy Center (Formerly Midwest Proton Radiotherapy Institute), Bloomington, Indiana 47408 (United States)

    2011-12-15

    Purpose: Particle beam therapy is associated with significant startup and operational cost. Multileaf collimator (MLC) provides an attractive option to improve the efficiency and reduce the treatment cost. A direct transfer of the MLC technology from external beam radiation therapy is intuitively straightforward to proton therapy. However, activation, neutron production, and the associated secondary cancer risk in proton beam should be an important consideration which is evaluated. Methods: Monte Carlo simulation with FLUKA particle transport code was applied in this study for a number of treatment models. The authors have performed a detailed study of the neutron generation, ambient dose equivalent [H*(10)], and activation of a typical tungsten MLC and compared with those obtained from a brass aperture used in a typical proton therapy system. Brass aperture and tungsten MLC were modeled by absorber blocks in this study, representing worst-case scenario of a fully closed collimator. Results: With a tungsten MLC, the secondary neutron dose to the patient is at least 1.5 times higher than that from a brass aperture. The H*(10) from a tungsten MLC at 10 cm downstream is about 22.3 mSv/Gy delivered to water phantom by noncollimated 200 MeV beam of 20 cm diameter compared to 14 mSv/Gy for the brass aperture. For a 30-fraction treatment course, the activity per unit volume in brass aperture reaches 5.3 x 10{sup 4} Bq cm{sup -3} at the end of the last treatment. The activity in brass decreases by a factor of 380 after 24 h, additional 6.2 times after 40 days of cooling, and is reduced to background level after 1 yr. Initial activity in tungsten after 30 days of treating 30 patients per day is about 3.4 times higher than in brass that decreases only by a factor of 2 after 40 days and accumulates to 1.2 x 10{sup 6} Bq cm{sup -3} after a full year of operation. The daily utilization of the MLC leads to buildup of activity with time. The overall activity continues to increase

  9. Experimental Program for the CLIC test facility 3 test beam line

    CERN Document Server

    Adli, E; Dobert, S; Olvegaard, M; Schulte, D; Syratchev, I; Lillestol, Reidar

    2010-01-01

    The CLIC Test Facility 3 Test Beam Line is the first prototype for the CLIC drive beam decelerator. Stable transport of the drive beam under deceleration is a mandatory component in the CLIC two-beam scheme. In the Test Beam Line more than 50% of the total energy will be extracted from a 150 MeV, 28 A electron drive beam, by the use of 16 power extraction and transfer structures. A number of experiments are foreseen to investigate the drive beam characteristics under deceleration in the Test Beam Line, including beam stability, beam blow up and the efficiency of the power extraction. General benchmarking of decelerator simulation and theory studies will also be performed. Specially designed instrumentation including precision BPMs, loss monitors and a time-resolved spectrometer dump will be used for the experiments. This paper describes the experimental program foreseen for the Test Beam Line, including the relevance of the results for the CLIC decelerator studies.

  10. Final Report for the ''WSU Neutron Capture Therapy Facility Support''

    International Nuclear Information System (INIS)

    The objective for the cooperative research program for which this report has been written was to provide separate NCT facility user support for the students, faculty and scientists who would be doing the U.S. Department of Energy Office (DOE) of Science supported advanced radiotargeted research at the WSU 1 megawatt TRIGA reactor. The participants were the Idaho National laboratory (INL, P.I., Dave Nigg), the Veterinary Medical Research Center of Washington State University (WSU, Janean Fidel and Patrick Gavin), and the Washington State University Nuclear Radiation Center (WSU, P.I., Gerald Tripard). A significant number of DOE supported modifications were made to the WSU reactor in order to create an epithermal neutron beam while at the same time maintaining the other activities of the 1 MW reactor. These modifications were: (1) Removal of the old thermal column. (2) Construction and insertion of a new epithermal filter, collimator and shield. (3) Construction of a shielded room that could accommodate the very high radiation field created by an intense neutron beam. (4) Removal of the previous reactor core fuel cluster arrangement. (5) Design and loading of the new reactor core fuel cluster arrangement in order to optimize the neutron flux entering the epithermal neutron filter. (6) The integration of the shielded rooms interlocks and radiological controls into the SCRAM chain and operating electronics of the reactor. (7) Construction of a motorized mechanism for moving and remotely controlling the position of the entire reactor bridge. (8) The integration of the reactor bridge control electronics into the SCRAM chain and operating electronics of the reactor. (9) The design, construction and attachment to the support structure of the reactor of an irradiation box that could be inserted into position next to the face of the reactor. (Necessitated by the previously mentioned core rearrangement). All of the above modifications were successfully completed and tested

  11. CEBAF [Continuous Electron Beam Accelerator Facility] design overview and project status

    International Nuclear Information System (INIS)

    This paper discusses the design and specifications of the Continuous Electron Beam Accelerator Facility. Beam performance objectives are discussed, as well as the recirculating linac concept, the injector, cavities, cryogenic system, beam transport and optics, rf system and construction progress. 19 refs., 10 figs

  12. Ion beam facilities at IIT Kanpur for micro and nanoscale science and engineering

    International Nuclear Information System (INIS)

    An Ion Beam Centre for Science Engineering and Technology (IBC-SET), equipped with different types of low energy ion beam facilities ranging from few keV to few MeV, is being envisaged at IIT Kanpur. This paper describes the existing and planned ion beam facilities under IBC-SET, namely the Focused Ion Beam System and 1.7 MV Tandetron accelerator respectively, and gives outline of the proposed research programs in science and engineering fields using the mili, micro and nanometer size beams of different ions. (author)

  13. MedAustron: The Austrian ion therapy facility

    Science.gov (United States)

    Benedikt, Michael

    MedAustron is a synchrotron-based light-ion beam therapy center for cancer treatment as well as for clinical and non-clinical research in Wiener Neustadt, Austria. The center is designed for the treatment of up to 1200 patients per year and for non-clinical research in the areas of radiobiology and medical radiation physics, as well as in experimental physics. MedAustron is an interdisciplinary project, benefiting from close cooperation and knowledge transfer with medical, scientific and research institutes on the national and international level. Three medical irradiation rooms will allow quasi-permanent patient treatment during two shifts on working days. The remaining beam time will be used for non-clinical research applications in a dedicated fourth irradiation room. The expected start of operation of MedAustron is mid-2016...

  14. ILL polarised hot-neutron beam facility D3

    International Nuclear Information System (INIS)

    D3 is a very comprehensive polarised beam facility at the renewed hot neutron source of the Institut Laue-Langevin (ILL). In magnetic field up to 10T, it exploits the spin dependency of the neutron scattering cross-section for determining unpaired electron magnetisation in crystals. The technique applies very successfully to molecular compounds, heavy fermions, high-Tc superconductors, transition metals and actinide alloys.Within the frame of the ILL Millennium Programme, we have recently added polarisation analysis by taking advantage of 3He spin filters and built a dedicated third-generation Cryopad for carrying out spherical neutron polarimetry experiments. In the case of magnetic structures, this leads to the direct determination of the magnetic interaction vector. Hence, D3 has become one of the most powerful tool for solving complex AF structures that had proven to be intractable when employing other techniques. Moreover, when the magnetic and nuclear scattering occur at the same position in the reciprocal space, it allows a precise determination of the AF magnetisation distributions.D3 can also be used for many purposes other than diffraction experiments, e.g. the search for the T-odd asymmetry of light particle emission in Pu239 ternary fission

  15. High-Energy Neutron Beam Facilities and Nuclear Data Measurements at the Svedberg Laboratory

    International Nuclear Information System (INIS)

    The Svedberg Laboratory (TSL) belongs to Uppsala University and exploits the Gustaf Werner cyclotron that delivers beams of protons and heavy ions to different beam lines and irradiation facilities. The main activities at TSL comprise proton treatment of cancer patients, radiation testing services, detector development, and nuclear data measurements. Currently, two high-energy neutron beam facilities are in regular use at TSL: (1) The quasi-monoenergetic neutron facility (QMN), and (2) The ANITA facility (Atmospheric-like Neutrons from thIck TArget). Both the facilities are driven by the proton beam from the cyclotron, with energy selectable in the range 20 – 180 MeV. The beam is pulsed, which allows one to use time-of-flight techniques. In the present report, we describe the neutron beam facilities at TSL, with focus on the QMN facility, including beam monitors as well as quality assurance and user support routines. Furthermore, we give an overview of neutron nuclear data measurements performed at the QMN facility. (author)

  16. The 50 MeV Beam Test Facility at LBL

    International Nuclear Information System (INIS)

    A new beam line, expected to be built by September 1993, will transport the 50 MeV electron beam from the ALS LINAC into an experimental area to support various R ampersand D activities in the Center for Beam Physics at LBL. A variety of experiments are planned involving the interaction of such a relativistic electron beam with plasmas (plasma focusing), laser beams (generation of femtosecond X-ray pulses) and electromagnetic cavities (Crab cavities etc....). The beam line is designed using the measured emittance and Twiss parameters of the ALS linac. It accommodates the different requirements of the various experiments on the electron beam properties (charge, energy, pulse length) and on the handling of the beam before and after the interaction point. Special attention has also been given to incorporate diagnostics for measuring the beam properties (such as the electron energy, bunch length and charge) needed in the interpretation of the experiments

  17. Beam test of compact ECR ion source for carbon therapy

    International Nuclear Information System (INIS)

    Ion source for medical facilities should have characteristics of easy maintenance, low electric power, good stability and long operation time without maintenance (one year or more). Based on the proto type compact source, a 10 GHz compact ECR ion source with all permanent magnets has been developed. Peaks of the mirror magnetic field along the beam axis are 0.59 T at the extraction side and 0.87 T at the gas injection side, respectively, while the minimum B strength is 0.25 T. The source has a diameter of 320 mm and a length of 295 mm. The result of beam tests shows that a C4+ intensity of 530 μA was obtained under an extraction voltage of 45 kV. This paper describes the design detail and the experimental results for the new source. (author)

  18. Performance of MACACO Compton telescope for ion-beam therapy monitoring: first test with proton beams

    Science.gov (United States)

    Solevi, Paola; Muñoz, Enrique; Solaz, Carles; Trovato, Marco; Dendooven, Peter; Gillam, John E.; Lacasta, Carlos; Oliver, Josep F.; Rafecas, Magdalena; Torres-Espallardo, Irene; Llosá, Gabriela

    2016-07-01

    In order to exploit the advantages of ion-beam therapy in a clinical setting, delivery verification techniques are necessary to detect deviations from the planned treatment. Efforts are currently oriented towards the development of devices for real-time range monitoring. Among the different detector concepts proposed, Compton cameras are employed to detect prompt gammas and represent a valid candidate for real-time range verification. We present the first on-beam test of MACACO, a Compton telescope (multi-layer Compton camera) based on lanthanum bromide crystals and silicon photo-multipliers. The Compton telescope was first characterized through measurements and Monte Carlo simulations. The detector linearity was measured employing 22Na and Am-Be sources, obtaining about 10% deviation from linearity at 3.44 MeV. A spectral image reconstruction algorithm was tested on synthetic data. Point-like sources emitting gamma rays with energy between 2 and 7 MeV were reconstructed with 3–5 mm resolution. The two-layer Compton telescope was employed to measure radiation emitted from a beam of 150 MeV protons impinging on a cylindrical PMMA target. Bragg-peak shifts were achieved via adjustment of the PMMA target location and the resulting measurements used during image reconstruction. Reconstructed Bragg peak profiles proved sufficient to observe peak-location differences within 10 mm demonstrating the potential of the MACACO Compton Telescope as a monitoring device for ion-beam therapy.

  19. The potential of proton beam therapy in paediatric cancer

    Energy Technology Data Exchange (ETDEWEB)

    Bjoerk-Eriksson, Thomas [Sahlgrenska Univ. Hospital, Goeteborg (Sweden). Dept. of Oncology; Glimelius, Bengt [Karolinska Inst., Stockholm (Sweden). Dept. of Oncology and Pathology; Akademiska sjukhuset, Uppsala (Sweden). Dept. of Oncology, Radiology and Clinical Immunology

    2005-12-01

    A group of Swedish oncologists and hospital physicists have estimated the number of patients in Sweden suitable for proton beam therapy. The estimations have been based on current statistics of tumour incidence, number of patients potentially eligible for radiation treatment, scientific support from clinical trials and model dose planning studies and knowledge of the dose-response relations of different tumours and normal tissues. It is estimated that in paediatric cancers, proton beams are of potential importance in 80-100 children annually in Sweden. About 20 of the patients have medulloblastoma. The main purpose is to reduce late sequelae, but these are also increased chances to avoid myelosupression during e.g. concomitant chemo-radiation and to further intensify the chemotherapy.

  20. Dosimetry auditing procedure with alanine dosimeters for light ion beam therapy

    International Nuclear Information System (INIS)

    Background and purpose: In the next few years the number of facilities providing ion beam therapy with scanning beams will increase. An auditing process based on an end-to-end test (including CT imaging, planning and dose delivery) could help new ion therapy centres to validate their entire logistic chain of radiation delivery. An end-to-end procedure was designed and tested in both scanned proton and carbon ion beams, which may also serve as a dosimetric credentialing procedure for clinical trials in the future. The developed procedure is focused only on physical dose delivery and the validation of the biological dose is out of scope of the current work. Materials and methods: The audit procedure was based on a homogeneous phantom that mimics the dimension of a head (20 × 20 × 21 cm3). The phantom can be loaded either with an ionisation chamber or 20 alanine dosimeters plus 2 radiochromic EBT films. Dose verification aimed at measuring a dose of 10 Gy homogeneously delivered to a virtual-target volume of 8 × 8 × 12 cm3. In order to interpret the readout of the irradiated alanine dosimeters additional Monte Carlo simulations were performed to calculate the energy dependent detector response of the particle fluence in the alanine detector. A pilot run was performed with protons and carbon ions at the Heidelberg Ion Therapy facility (HIT). Results: The mean difference of the absolute physical dose measured with the alanine dosimeters compared with the expected dose from the treatment planning system was −2.4 ± 0.9% (1σ) for protons and −2.2 ± 1.1% (1σ) for carbon ions. The measurements performed with the ionisation chamber indicate this slight underdosage with a dose difference of −1.7% for protons and −1.0% for carbon ions. The profiles measured by radiochromic films showed an acceptable homogeneity of about 3%. Conclusions: Alanine dosimeters are suitable detectors for dosimetry audits in ion beam therapy and the presented end-to-end test is

  1. Status of the Medaustron Ion Beam Therapy centre

    CERN Document Server

    Dorda, U; Osmic, F; Benedikt, M

    2012-01-01

    MedAustron is a synchrotron based light-ion beam therapy centre for cancer treatment as well as for clinical and non-clinical research currently in its construction phase. The accelerator design is based on the CERN-PIMMS study and its technical implementation by CNAO. This paper presents a status overview over the whole project detailing the achieved progress of the building construction & technical infrastructure installation in Wiener Neustadt, Austria, as well as of the accelerator development, performed at CERN and partially at PSI. The design and procurement status and future planning of the various accelerator components is elaborated.

  2. Physical aspects of electron-beam arc therapy

    Energy Technology Data Exchange (ETDEWEB)

    Khan, F.M.; Fullerton, G.D.; Lee, J.M.F.; Moore, V.C.; Levitt, S.H.

    1977-08-01

    The effect of different parameters on dose distribution in electron-beam arc therapy was studied in order to develop a technique for routine clinical use. A special diaphragm was designed to facilitate telecentric rotation. Dosimetry was performed with an ion chamber, film, and LiF powder in cylindrical polystyrene phantoms and an Alderson Rando phantom. Dose distributions were evaluated with regard to dose homogeneity, and a method of sharpening the dose fall-off near the ends of the arc was proposed. Criteria for selection of isocenter depth and field size were developed. Methods of dose calculation, calibration, and treatment planning are discussed.

  3. Alanine EPR dosimeter response in proton therapy beams

    International Nuclear Information System (INIS)

    We report a series of measurements directed to assess the suitability of alanine as a mailable dosimeter for dosimetry quality assurance of proton radiation therapy beams. These measurements include dose-response of alanine at 140 MeV, and comparison of response vs energy with a parallel plate ionization chamber. All irradiations were made at the Harvard Cyclotron Laboratory, and the dosimeters were read at NIST. The results encourage us that alanine could be expected to serve as a mailable dosimeter with systematic error due to differential energy response no greater than 3% when doses of 25 Gy are used. (Author)

  4. SIRIUS: A Proposal for an accelerated Radioactive Beams Facility at ISIS

    International Nuclear Information System (INIS)

    A Proposal for a future Radioactive Beams Facility has been developed based on ISIS, the world's brightest pulsed neutron source. Radioactive ions are produced by the spallation process driven by a 100 μA, 800 MeV proton beam delivered from the ISIS synchrotron accelerator. This is ten times more powerful than currently available in the world today, and follows on from the successful work performed by the RIST project to develop a high power radioactive beam target for such a facility. The proposed design provides for both low (200 keV), and high energy (10 MeV/A) radioactive beams with high to medium mass resolution. A flexible facility layout allows the maximum simultaneous and independent use of the radioactive beams by a number of different users. An overview of the proposed facility is presented

  5. Beam line shielding calculations for an Electron Accelerator Mo-99 production facility

    Energy Technology Data Exchange (ETDEWEB)

    Mocko, Michal [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-05-03

    The purpose of this study is to evaluate the photon and neutron fields in and around the latest beam line design for the Mo-99 production facility. The radiation dose to the beam line components (quadrupoles, dipoles, beam stops and the linear accelerator) are calculated in the present report. The beam line design assumes placement of two cameras: infra red (IR) and optical transition radiation (OTR) for continuous monitoring of the beam spot on target during irradiation. The cameras will be placed off the beam axis offset in vertical direction. We explored typical shielding arrangements for the cameras and report the resulting neutron and photon dose fields.

  6. Examination of Beryllium Under Intense High Energy Proton Beam at CERN's HiRadMat Facility

    CERN Document Server

    Ammigan, K; Hurh, P; Zwaska, R; Atherton, A; Caretta, O; Davenne, t; Densham, C; Fitton, M; Loveridge, P; O'Dell, J; Roberts, S; Kuksenko, v; Butcher, M; Calviani, M; Guinchard, M; Losito, R

    2015-01-01

    Beryllium is extensively used in various accelerator beam lines and target facilities as material for beam win- dows, and to a lesser extent, as secondary particle produc- tion targets. With increasing beam intensities of future ac- celerator facilities, it is critical to understand the response of beryllium under extreme conditions to avoid compro- mising particle production efficiency by limiting beam pa- rameters. As a result, the planned experiment at CERN’s HiRadMat facility will take advantage of the test facility’s tunable high intensity proton beam to probe and investigate the damage mechanisms of several grades of beryllium. The test matrix will consist of multiple arrays of thin discs of varying thicknesses as well as cylinders, each exposed to increasing beam intensities. Online instrumentations will acquire real time temperature, strain, and vibration data of the cylinders, while Post-Irradiation-Examination (PIE) of the discs will exploit advanced microstructural characteri- zation and imagin...

  7. OPTIMIZATION OF THE EPITHERMAL NEUTRON BEAM FOR BORON NEUTRON CAPTURE THERAPY AT THE BROOKHAVEN MEDICAL RESEARCH REACTOR

    International Nuclear Information System (INIS)

    Clinical trials of Boron Neutron Capture Therapy for patients with malignant brain tumor had been carried out for half a decade, using an epithermal neutron beam at the Brookhaven's Medical Reactor. The decision to permanently close this reactor in 2000 cut short the efforts to implement a new conceptual design to optimize this beam in preparation for use with possible new protocols. Details of the conceptual design to produce a higher intensity, more forward-directed neutron beam with less contamination from gamma rays, fast and thermal neutrons are presented here for their potential applicability to other reactor facilities. Monte Carlo calculations were used to predict the flux and absorbed dose produced by the proposed design. The results were benchmarked by the dose rate and flux measurements taken at the facility then in use

  8. HiRadMat: A high‐energy, pulsed beam, material irradiation facility

    CERN Multimedia

    Charitonidis, Nikolaos

    2016-01-01

    HiRadMat is a facility constructed in 2011, designed to provide high-intensity pulsed beams to an irradiation area where different material samples or accelerator components can be tested. The facility, located at the CERN SPS accelerator complex, uses a 440 GeV proton beam with a pulse length up to 7.2 μs and a maximum intensity up to 1E13 protons / pulse. The facility, a unique place for performing state-of-the art beam-to-material experiments, operates under transnational access and welcomes and financially supports, under certain conditions, experimental teams to perform their experiments.

  9. Imaging dose assessment for IGRT in particle beam therapy

    International Nuclear Information System (INIS)

    Introduction: Image-guided advanced photon and particle beam treatments are promising options for improving lung treatments. Extensive use of imaging increases the overall patient dose. The aim of this study was to determine the imaging dose for different IGRT solutions used in photon and particle beam therapy. Material and methods: Measurements were performed in an Alderson phantom with TLDs. Clinically applied protocols for orthogonal planar kV imaging, stereoscopic imaging, CT scout views, fluoroscopy, CT, 4D-CT and CBCT were investigated at five ion beam centers and one conventional radiotherapy department. The overall imaging dose was determined for a patient undergoing a lung tumor irradiation with institute specific protocols. Results: OAR doses depended on imaging modality and OAR position. Dose values were in the order of 1 mGy for planar and stereoscopic imaging and 10–50 mGy for volumetric imaging, except for one CBCT device leading to lower doses. The highest dose per exam (up to 150 mGy to the skin) was recorded for a 3-min fluoroscopy. Discussion: Modalities like planar kV or stereoscopic imaging result in very low doses (∼1 mGy) to the patient. Imaging a moving target during irradiation, low-dose protocols and protocol optimization can reduce the imaging dose to the patient substantially

  10. Optimization of In-Beam Positron Emission Tomography for Monitoring Heavy Ion Tumor Therapy

    OpenAIRE

    Vieira Crespo, Paulo Alexandre

    2010-01-01

    In-beam positron emission tomography (in-beam PET) is currently the only method for an in-situ monitoring of highly tumor-conformed charged hadron therapy. In such therapy, the clinical effect of deviations from treatment planning is highly minimized by implementing safety margins around the tumor and selecting proper beam portals. Nevertheless, in-beam PET is able to detect eventual, undesirable range deviations and anatomical modifications during fractionated irradiation, to verify the accu...

  11. Fast optimization and dose calculation in scanned ion beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Hild, S. [Department of Biophysics, GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64291 Darmstadt (Germany); Department of Radiation Oncology, University Clinic Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen (Germany); Institute for Medical Physics and Radiation Protection, University of Applied Sciences, 35390 Giessen (Germany); Graeff, C.; Trautmann, J.; Kraemer, M. [Department of Biophysics, GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64289 Darmstadt (Germany); Zink, K. [Institute for Medical Physics and Radiation Protection, University of Applied Sciences, 35390 Giessen, Germany and Department of Radiotherapy and Radiooncology, University Hospital Giessen-Marburg, 35043 Marburg (Germany); Durante, M. [Department of Biophysics, GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64289 Darmstadt, Germany and Faculty of Physics, Technische Universität Darmstadt, 64289 Darmstadt (Germany); Bert, C., E-mail: christoph.bert@uk-erlangen.de [Department of Biophysics, GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64289 Darmstadt, Germany and Department of Radiation Oncology, University Clinic Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen (Germany)

    2014-07-15

    Purpose: Particle therapy (PT) has advantages over photon irradiation on static tumors. An increased biological effectiveness and active target conformal dose shaping are strong arguments for PT. However, the sensitivity to changes of internal geometry complicates the use of PT for moving organs. In case of interfractionally moving objects adaptive radiotherapy (ART) concepts known from intensity modulated radiotherapy (IMRT) can be adopted for PT treatments. One ART strategy is to optimize a new treatment plan based on daily image data directly before a radiation fraction is delivered [treatment replanning (TRP)]. Optimizing treatment plans for PT using a scanned beam is a time consuming problem especially for particles other than protons where the biological effective dose has to be calculated. For the purpose of TRP, fast optimization and fast dose calculation have been implemented into the GSI in-house treatment planning system (TPS) TRiP98. Methods: This work reports about the outcome of a code analysis that resulted in optimization of the calculation processes as well as implementation of routines supporting parallel execution of the code. To benchmark the new features, the calculation time for therapy treatment planning has been studied. Results: Compared to the original version of the TPS, calculation times for treatment planning (optimization and dose calculation) have been improved by a factor of 10 with code optimization. The parallelization of the TPS resulted in a speedup factor of 12 and 5.5 for the original version and the code optimized version, respectively. Hence the total speedup of the new implementation of the authors' TPS yielded speedup factors up to 55. Conclusions: The improved TPS is capable of completing treatment planning for ion beam therapy of a prostate irradiation considering organs at risk in this has been overseen in the review process. Also see below 6 min.

  12. Fast optimization and dose calculation in scanned ion beam therapy

    International Nuclear Information System (INIS)

    Purpose: Particle therapy (PT) has advantages over photon irradiation on static tumors. An increased biological effectiveness and active target conformal dose shaping are strong arguments for PT. However, the sensitivity to changes of internal geometry complicates the use of PT for moving organs. In case of interfractionally moving objects adaptive radiotherapy (ART) concepts known from intensity modulated radiotherapy (IMRT) can be adopted for PT treatments. One ART strategy is to optimize a new treatment plan based on daily image data directly before a radiation fraction is delivered [treatment replanning (TRP)]. Optimizing treatment plans for PT using a scanned beam is a time consuming problem especially for particles other than protons where the biological effective dose has to be calculated. For the purpose of TRP, fast optimization and fast dose calculation have been implemented into the GSI in-house treatment planning system (TPS) TRiP98. Methods: This work reports about the outcome of a code analysis that resulted in optimization of the calculation processes as well as implementation of routines supporting parallel execution of the code. To benchmark the new features, the calculation time for therapy treatment planning has been studied. Results: Compared to the original version of the TPS, calculation times for treatment planning (optimization and dose calculation) have been improved by a factor of 10 with code optimization. The parallelization of the TPS resulted in a speedup factor of 12 and 5.5 for the original version and the code optimized version, respectively. Hence the total speedup of the new implementation of the authors' TPS yielded speedup factors up to 55. Conclusions: The improved TPS is capable of completing treatment planning for ion beam therapy of a prostate irradiation considering organs at risk in this has been overseen in the review process. Also see below 6 min

  13. Optimization study for an epithermal neutron beam for boron neutron capture therapy at the University of Virginia Research Reactor

    International Nuclear Information System (INIS)

    The non-surgical brain cancer treatment modality, Boron Neutron Capture Therapy (BNCT), requires the use of an epithermal neutron beam. This purpose of this thesis was to design an epithermal neutron beam at the University of Virginia Research Reactor (UVAR) suitable for BNCT applications. A suitable epithermal neutron beam for BNCT must have minimal fast neutron and gamma radiation contamination, and yet retain an appreciable intensity. The low power of the UVAR core makes reaching a balance between beam quality and intensity a very challenging design endeavor. The MCNP monte carlo neutron transport code was used to develop an equivalent core radiation source, and to perform the subsequent neutron transport calculations necessary for beam model analysis and development. The code accuracy was validated by benchmarking output against experimental criticality measurements. An epithermal beam was designed for the UVAR, with performance characteristics comparable to beams at facilities with cores of higher power. The epithermal neutron intensity of this beam is 2.2 x 108 n/cm2 · s. The fast neutron and gamma radiation KERMA factors are 10 x 10-11cGy·cm2/nepi and 20 x 10-11 cGy·cm2/nepi, respectively, and the current-to-flux ratio is 0.85. This thesis has shown that the UVAR has the capability to provide BNCT treatments, however the performance characteristics of the final beam of this study were limited by the low core power

  14. Fast pencil beam dose calculation for proton therapy using a double-Gaussian beam model

    Directory of Open Access Journals (Sweden)

    Joakim eda Silva

    2015-12-01

    Full Text Available The highly conformal dose distributions produced by scanned proton pencil beams are more sensitive to motion and anatomical changes than those produced by conventional radiotherapy. The ability to calculate the dose in real time as it is being delivered would enable, for example, online dose monitoring, and is therefore highly desirable. We have previously described an implementation of a pencil beam algorithm running on graphics processing units (GPUs intended specifically for online dose calculation. Here we present an extension to the dose calculation engine employing a double-Gaussian beam model to better account for the low-dose halo. To the best of our knowledge, it is the first such pencil beam algorithm for proton therapy running on a GPU. We employ two different parametrizations for the halo dose, one describing the distribution of secondary particles from nuclear interactions found in the literature and one relying on directly fitting the model to Monte Carlo simulations of pencil beams in water. Despite the large width of the halo contribution, we show how in either case the second Gaussian can be included whilst prolonging the calculation of the investigated plans by no more than 16%, or the calculation of the most time-consuming energy layers by about 25%. Further, the calculation time is relatively unaffected by the parametrization used, which suggests that these results should hold also for different systems. Finally, since the implementation is based on an algorithm employed by a commercial treatment planning system, it is expected that with adequate tuning, it should be able to reproduce the halo dose from a general beam line with sufficient accuracy.

  15. Fault detection and protection system for neutral beam generators on the Neutral Beam Engineering Test Facility (NBETF)

    International Nuclear Information System (INIS)

    Neutral beam sources, their power supplies and instrumentation can be damaged from high voltage sparkdown or from overheating due to excessive currents. The Neutral Beam Engineering Test Facility (NBETF) in Berkeley has protective electronic hardware that senses a condition outside a safe operating range and generates a response to terminate such a fault condition. A description of this system is presented in this paper. 8 references, 2 figures, 2 tables

  16. Experimental and Simulated Characterization of a Beam Shaping Assembly for Accelerator- Based Boron Neutron Capture Therapy (AB-BNCT)

    International Nuclear Information System (INIS)

    In the frame of the construction of a Tandem Electrostatic Quadrupole Accelerator facility devoted to the Accelerator-Based Boron Neutron Capture Therapy, a Beam Shaping Assembly has been characterized by means of Monte-Carlo simulations and measurements. The neutrons were generated via the 7Li(p, n)7Be reaction by irradiating a thick LiF target with a 2.3 MeV proton beam delivered by the TANDAR accelerator at CNEA. The emerging neutron flux was measured by means of activation foils while the beam quality and directionality was evaluated by means of Monte Carlo simulations. The parameters show compliance with those suggested by IAEA. Finally, an improvement adding a beam collimator has been evaluated.

  17. Beta Beams: an accelerator based facility to explore Neutrino oscillation physics

    CERN Document Server

    Wildner, E; Hansen, C; De Melo Mendonca, T; Stora, T; Payet, J; Chance, A; Zorin, V; Izotov, I; Rasin, S; Sidorov, A; Skalyga, V; De Angelis, G; Prete, G; Cinausero, M; Kravchuk, VL; Gramegna, F; Marchi, T; Collazuol, G; De Rosa, G; Delbar, T; Loiselet, M; Keutgen, T; Mitrofanov, S; Lamy, T; Latrasse, L; Marie-Jeanne, M; Sortais, P; Thuillier, T; Debray, F; Trophime, C; Hass, M; Hirsh, T; Berkovits, D; Stahl, A

    2011-01-01

    The discovery that the neutrino changes flavor as it travels through space has implications for the Standard Model of particle physics (SM)[1]. To know the contribution of neutrinos to the SM, needs precise measurements of the parameters governing the neutrino oscillations. This will require a high intensity beam-based neutrino oscillation facility. The EURONu Design Study will review three currently accepted methods of realizing this facility (the so-called Super-Beams, Beta Beams and Neutrino Factories) and perform a cost assessment that, coupled with the physics performance, will give means to the European research authorities to make a decision on the layout and construction of the future European neutrino oscillation facility. ”Beta Beams” produce collimated pure electron neutrino and antineutrino beams by accelerating beta active ions to high energies and letting them decay in a race-track shaped storage ring. EURONu Beta Beams are based on CERNs infrastructure and the fact that some of the already ...

  18. Charged particle therapy with mini-segmented beams

    Directory of Open Access Journals (Sweden)

    F. Avraham eDilmanian

    2015-12-01

    Full Text Available One of the fundamental attributes of proton therapy and carbon ion therapy is the ability of these charged particles to spare tissue distal to the targeted tumor. This significantly reduces normal tissue toxicity and has the potential to translate to a wider therapeutic index. Although, in general, particle therapy also reduces dose to the proximal tissues, particularly in the vicinity of the target, dose to the skin and to other very superficial tissues tends to be higher than that of megavoltage x-rays. The methods presented here, namely Interleaved carbon minibeams and Radiosurgery with arrays of proton and light ion minibeams, both utilize beams segmented into arrays of parallel minibeams of about 0.3 mm incident beam size. These minibeam arrays spare tissues, as demonstrated by synchrotron x-ray experiments. An additional feature of particle minibeams is their gradual broadening due to multiple Coulomb scattering as they penetrate tissues. In the case of interleaved carbon minibeams, which do not broaden much, two arrays of planar carbon minibeams that remain parallel at target depth, are aimed at the target from 90º angles and made to interleave at the target to produce a solid radiation field within the target. As a result the surrounding tissues are exposed only to individual carbon minibeam arrays and are therefore spared. The method was used in four-directional geometry at the NASA Space Radiation Laboratory to ablate a 6.5-mm target in a rabbit brain at a single exposure with 40 Gy physical absorbed dose. Contrast-enhanced magnetic resonance imaging and histology six month later showed very focal target necrosis with nearly no damage to the surrounding brain. As for minibeams of protons and light ions, for which the minibeam broadening is substantial, measurements at MD Anderson Cancer Center in Houston, Texas, and Monte Carlo simulations showed that the broadening minibeams will merge with their neighbors at a certain tissue depth

  19. Demonstration of the importance of a dedicated neutron beam monitoring system for BNCT facility.

    Science.gov (United States)

    Chao, Der-Sheng; Liu, Yuan-Hao; Jiang, Shiang-Huei

    2016-01-01

    The neutron beam monitoring system is indispensable to BNCT facility in order to achieve an accurate patient dose delivery. The neutron beam monitoring of a reactor-based BNCT (RB-BNCT) facility can be implemented through the instrumentation and control system of a reactor provided that the reactor power level remains constant during reactor operation. However, since the neutron flux in reactor core is highly correlative to complicated reactor kinetics resulting from such as fuel depletion, poison production, and control blade movement, some extent of variation may occur in the spatial distribution of neutron flux in reactor core. Therefore, a dedicated neutron beam monitoring system is needed to be installed in the vicinity of the beam path close to the beam exit of the RB-BNCT facility, where it can measure the BNCT beam intensity as closely as possible and be free from the influence of the objects present around the beam exit. In this study, in order to demonstrate the importance of a dedicated BNCT neutron beam monitoring system, the signals originating from the two in-core neutron detectors installed at THOR were extracted and compared with the three dedicated neutron beam monitors of the THOR BNCT facility. The correlation of the readings between the in-core neutron detectors and the BNCT neutron beam monitors was established to evaluate the improvable quality of the beam intensity measurement inferred by the in-core neutron detectors. In 29 sampled intervals within 16 days of measurement, the fluctuations in the mean value of the normalized ratios between readings of the three BNCT neutron beam monitors lay within 0.2%. However, the normalized ratios of readings of the two in-core neutron detectors to one of the BNCT neutron beam monitors show great fluctuations of 5.9% and 17.5%, respectively. PMID:26595774

  20. Physics studies with brilliant narrow-width -beams at the new ELI-NP Facility

    Indian Academy of Sciences (India)

    Dimiter L Balabanski; ELI-NP Science Team

    2014-11-01

    The Extreme Light Infrastructure Nuclear Physics (ELI-NP) Facility in Magurele is a European research centre for ultrahigh intensity lasers, laser–matter interaction, nuclear science and material science using laser-driven radiation beams. It is the first project within the European Strategic Forum for Research Infrastructure (ESFRI) agenda financed by the European Regional Development Fund. The nuclear physics research programme of the facility is focussed on studies with brilliant narrow-width -beams and experiments in extreme laser fields.

  1. New developments of 11C post-accelerated beams for hadron therapy and imaging

    Science.gov (United States)

    Augusto, R. S.; Mendonca, T. M.; Wenander, F.; Penescu, L.; Orecchia, R.; Parodi, K.; Ferrari, A.; Stora, T.

    2016-06-01

    Hadron therapy was first proposed in 1946 and is by now widespread throughout the world, as witnessed with the design and construction of the CNAO, HIT, PROSCAN and MedAustron treatment centres, among others. The clinical interest in hadron therapy lies in the fact that it delivers precision treatment of tumours, exploiting the characteristic shape (the Bragg peak) of the energy deposition in the tissues for charged hadrons. In particular, carbon ion therapy is found to be biologically more effective, with respect to protons, on certain types of tumours. Following an approach tested at NIRS in Japan [1], carbon ion therapy treatments based on 12C could be combined or fully replaced with 11C PET radioactive ions post-accelerated to the same energy. This approach allows providing a beam for treatment and, at the same time, to collect information on the 3D distributions of the implanted ions by PET imaging. The production of 11C ion beams can be performed using two methods. A first one is based on the production using compact PET cyclotrons with 10-20 MeV protons via 14N(p,α)11C reactions following an approach developed at the Lawrence Berkeley National Laboratory [2]. A second route exploits spallation reactions 19F(p,X)11C and 23Na(p,X)11C on a molten fluoride salt target using the ISOL (isotope separation on-line) technique [3]. This approach can be seriously envisaged at CERN-ISOLDE following recent progresses made on 11C+ production [4] and proven post-acceleration of pure 10C3/6+ beams in the REX-ISOLDE linac [5]. Part of the required components is operational in radioactive ion beam facilities or commercial medical PET cyclotrons. The driver could be a 70 MeV, 1.2 mA proton commercial cyclotron, which would lead to 8.1 × 10711C6+ per spill. This intensity is appropriate using 11C ions alone for both imaging and treatment. Here we report on the ongoing feasibility studies of such approach, using the Monte Carlo particle transport code FLUKA [6,7] to simulate

  2. Radioactive beam diagnostics status and development at the Spiral facility

    International Nuclear Information System (INIS)

    In 2001 the first radioactive beam will be accelerated in the CIME cyclotron of the SPIRAL project at GANIL. In order to be able to tune such low intensity beams in the cyclotron (down to few particles per second), a silicon and a scintillator detectors are mounted on probes. They measure the beam energy and the beam phase/RF in the cyclotron as a function of the radius. Such fragile diagnostics are meant to be used routinely from the control room by non-specialists in instrumentation and in presence of various beam intensities. Therefore, a program is developed to control and secure the acquisition procedure, the measurements and the isochronism correction. Additional detectors are installed at a fixed position in the ejection line before the experimental areas. Additionally, a diamond detector is foreseen to be installed in the machine to be tested in order to ease the CIME operation. (authors)

  3. High-resolution mass separator and 60 m beam transport line for the radioactive nuclear beam facility at INS

    International Nuclear Information System (INIS)

    A high resolution on-line isotope separator (ISOL) followed by a long beam transport line is under testing at INS, as a pilot radioactive beam facility for the E-arena of the Japanese Hadron Project. The ISOL has a unique feature in its high voltage potential configuration; it has two separation stages and both are electrically insulated from the ground. This feature is effective to eliminate impurities as well as to perform high resolution mass separation while keeping the injection beam velocity to the post accelerator constant. The design concept and present status of performance tests are reported. (author)

  4. New electron beam facility for irradiated plasma facing materials testing in hot cell

    Energy Technology Data Exchange (ETDEWEB)

    Sakamoto, N.; Kawamura, H. [Oarai Research Establishment, Ibaraki-ken (Japan); Akiba, M. [Naka Research Establishment, Ibaraki-ken (Japan)

    1995-09-01

    Since plasma facing components such as the first wall and the divertor for the next step fusion reactors are exposed to high heat loads and high energy neutron flux generated by the plasma, it is urgent to develop of plasma facing components which can resist these. Then, we have established electron beam heat facility ({open_quotes}OHBIS{close_quotes}, Oarai Hot-cell electron Beam Irradiating System) at a hot cell in JMTR (Japan Materials Testing Reactor) hot laboratory in order to estimate thermal shock resistivity of plasma facing materials and heat removal capabilities of divertor elements under steady state heating. In this facility, irradiated plasma facing materials (beryllium, carbon based materials and so on) and divertor elements can be treated. This facility consists of an electron beam unit with the maximum beam power of 50kW and the vacuum vessel. The acceleration voltage and the maximum beam current are 30kV (constant) and 1.7A, respectively. The loading time of electron beam is more than 0.1ms. The shape of vacuum vessel is cylindrical, and the mainly dimensions are 500mm in inner diameter, 1000mm in height. The ultimate vacuum of this vessel is 1 x 10{sup -4}Pa. At present, the facility for thermal shock test has been established in a hot cell. And performance estimation on the electron beam is being conducted. Presently, the devices for heat loading tests under steady state will be added to this facility.

  5. Laser Ion Source Operation at the TRIUMF Radioactive Ion Beam Facility

    Science.gov (United States)

    Lassen, J.; Bricault, P.; Dombsky, M.; Lavoie, J. P.; Gillner, M.; Gottwald, T.; Hellbusch, F.; Teigelhöfer, A.; Voss, A.; Wendt, K. D. A.

    2009-03-01

    The TRIUMF Resonant Ionization Laser Ion Source (RILIS) for radioactive ion beam production is presented, with target ion source, laser beam transport, laser system and operation. In this context aspects of titanium sapphire (TiSa) laser based RILIS and facility requirements are discussed and results from the first years of TRILIS RIB delivery are given.

  6. Physics at a future Neutrino Factory and super-beam facility

    NARCIS (Netherlands)

    Bandyopadhyay, A.; Choubey, S.; Gandhi, R.; Goswami, S.; Roberts, B. L.; Bouchez, J.; Antoniadis, I.; Ellis, J.; Giudice, G. F.; Schwetz, T.; Umasankar, S.; Karagiorgi, G.; Aguilar-Arevalo, A.; Conrad, J. M.; Shaevitz, M. H.; Pascoli, S.; Geer, S.; Campagne, J. E.; Rolinec, M.; Blondel, A.; Campanelli, M.; Kopp, J.; Lindner, M.; Peltoniemi, J.; Dornan, P. J.; Long, K.; Matsushita, T.; Rogers, C.; Uchida, Y.; Dracos, M.; Whisnant, K.; Casper, D.; Chen, Mu-Chun; Popov, B.; Aysto, J.; Marfatia, D.; Okada, Y.; Sugiyama, H.; Jungmann, K.; Lesgourgues, J.; Zisman, M.; Tortola, M. A.; Friedland, A.; Davidson, S.; Antusch, S.; Biggio, C.; Donini, A.; Fernandez-Martinez, E.; Gavela, B.; Maltoni, M.; Lopez-Pavon, J.; Rigolin, S.; Mondal, N.; Palladino, V.; Filthaut, F.; Albright, C.; de Gouvea, A.; Kuno, Y.; Nagashima, Y.; Mezzetto, M.; Lola, S.; Langacker, P.; Baldini, A.; Nunokawa, H.; Meloni, D.; Diaz, M.; King, S. F.; Zuber, K.; Akeroyd, A. G.; Grossman, Y.; Farzan, Y.; Tobe, K.; Aoki, Mayumi; Murayama, H.; Kitazawa, N.; Yasuda, O.; Petcov, S.; Romanino, A.; Chimenti, P.; Vacchi, A.; Smirnov, A. Yu; Couce, E.; Gomez-Cadenas, J. J.; Hernandez, P.; Sorel, M.; Valle, J. W. F.; Harrison, P. F.; Lunardini, C.; Nelson, J. K.; Barger, V.; Everett, L.; Huber, P.; Winter, W.; Fetscher, W.; van der Schaaf, A.

    2009-01-01

    The conclusions of the Physics Working Group of the International Scoping Study of a future Neutrino Factory and super-beam facility (the ISS) are presented. The ISS was carried out by the international community between NuFact05, (the 7th International Workshop on Neutrino Factories and Super-beams

  7. Selected List of Low Energy Beam Transport Facilities for Light-Ion, High-Intensity Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Prost, L. R. [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States)

    2016-02-17

    This paper presents a list of Low Energy Beam Transport (LEBT) facilities for light-ion, high-intensity accelerators. It was put together to facilitate comparisons with the PXIE LEBT design choices. A short discussion regarding the importance of the beam perveance in the choice of the transport scheme follows.

  8. Selected List of Low Energy Beam Transport Facilities for Light-Ion, High-Intensity Accelerators

    CERN Document Server

    Prost, Lionel R

    2016-01-01

    This paper presents a list of Low Energy Beam Transport (LEBT) facilities for light-ion, high-intensity accelerators. It was put together to facilitate comparisons with the PXIE LEBT design choices. A short discussion regarding the importance of the beam perveance in the choice of the transport scheme follows.

  9. The Clatterbridge high-energy neutron therapy facility: specification and performance

    International Nuclear Information System (INIS)

    A high energy neutron therapy facility has been installed at the Douglas Cyclotron Centre, Clatterbridge Hospital Merseyside, to extend M.R.C. clinical trials of fast neutrons. The neutron beam is produced by bombarding a beryllium target with 62 MeV protons. The target is isocentrically mounted with potential for 3600 rotation, with a fully variable collimator, giving a range of rectilinear field sizes from 5 cm x 5 cm to 30 cm x 30 cm. Basic neutron beam data including output, field flatness, penumbra and depth-dose data have been measured. For a 10 cm x 10 cm field, 50% depth dose occurs at 16.2 cm in water and output is 1.63 cGy μ A-1 min-1 at maximum dose depth. Effectiveness of the target shielding and neutron-induced radioactivity in the treatment head were also measured. It is concluded that the equipment meets design specifications and fully satisfies criticisms of earlier neutron therapy equipment. A full radiation survey showed that radiation levels present no significant staff hazard. (UK)

  10. ESTB: A New Beam Test Facility at SLAC

    Energy Technology Data Exchange (ETDEWEB)

    Pivi, M.; Fieguth, T.; Hast, C.; Iverson, R.; Jaros, J.; Jobe, K.; Keller, L.; Walz, D.; Weathersby, S.; Woods, M.; /SLAC

    2011-04-05

    End Station A Test Beam (ESTB) is a beam line at SLAC using a small fraction of the bunches of the 13.6 GeV electron beam from the Linac Coherent Light Source (LCLS), restoring test beam capabilities in the large End Station A (ESA) experimental hall. ESTB will provide one of a kind test beam essential for developing accelerator instrumentation and accelerator R&D, performing particle and particle astrophysics detector research, linear collider machine and detector interface (MDI) R&D studies, development of radiation-hard detectors, and material damage studies with several distinctive features. In the past, 18 institutions participated in the ESA program at SLAC. In stage I, 4 new kicker magnets will be added to divert 5 Hz of the LCLS beam to the A-line. A new beam dump will be installed and a new Personnel Protection System (PPS) is being built in ESA. In stage II, a secondary hadron target will be installed, able to produce pions up to about 12 GeV/c at 1 particle/pulse.

  11. Proceedings of the meeting on beam monitors for Cyclotrons and related facilities

    International Nuclear Information System (INIS)

    The meeting on the beam monitors for Cyclotrons and related facilities was held at Institute for Nuclear Study, University of Tokyo on February 24, 1993. This proceedings contains all the paper presented at the meeting, covering the present status of the beam instruments and their performances. The coverage area of this meeting was the ion sources, the cyclotrons, the linacs, the synchrotrons and the beam transport system. The meeting consisted of 12 plenary talks and 30 scientists and engineers participated. (author)

  12. Simulation of Particle Fluxes at the DESY-II Test Beam Facility

    International Nuclear Information System (INIS)

    In the course of this Master's thesis ''Simulation of Particle Fluxes at the DESY-II Test Beam Facility'' the test beam generation for the DESY test beam line was studied in detail and simulated with the simulation software SLIC. SLIC uses the Geant4 toolkit for realistic Monte Carlo simulations of particles passing through detector material.After discussing the physics processes relevant for the test beam generation and the principles of the beam generation itself, the software used is introduced together with a description of the functionality of the Geant4 Monte Carlo simulation. The simulation of the test beam line follows the sequence of the test beam generation. Therefore, it starts with the simulation of the beam bunch of the synchrotron accelerator DESY-II, and proceeds step by step with the single test beam line components. An additional benefit of this thesis is the provision of particle flux and trajectory maps, which make fluxes directly visible by following the particle tracks through the simulated beam line. These maps allow us to see each of the test beam line components, because flux rates and directions change rapidly at these points. They will also guide the decision for placements of future test beam line components and measurement equipment.In the end, the beam energy and its spread, and the beam rate of the final test beam in the test beam area were studied in the simulation, so that the results can be compared to the measured beam parameters. The test beam simulation of this Master's thesis will serve as a key input for future test beam line improvements.

  13. Diagnostics of the ITER neutral beam test facility

    Energy Technology Data Exchange (ETDEWEB)

    Pasqualotto, R.; Serianni, G.; Agostini, M.; Brombin, M.; Dalla Palma, M.; Gazza, E.; Pomaro, N.; Rizzolo, A.; Spolaore, M.; Zaniol, B. [Consorzio RFX, Associazione EURATOM-ENEA sulla Fusione, Corso Stati Uniti 4, I-35127 Padova (Italy); Sonato, P.; De Muri, M. [Consorzio RFX, Associazione EURATOM-ENEA sulla Fusione, Corso Stati Uniti 4, I-35127 Padova (Italy); Dipartimento di Ingegneria Elettrica, Padova University (Italy); Croci, G. [Istituto di Fisica del Plasma, Associazione EURATOM-ENEA-CNR, Milano (Italy); Gorini, G. [Istituto di Fisica del Plasma, Associazione EURATOM-ENEA-CNR, Milano (Italy); CNISM, Dipartimento di Fisica, Universita degli Studi di Milano-Bicocca, Milano (Italy)

    2012-02-15

    The ITER heating neutral beam (HNB) injector, based on negative ions accelerated at 1 MV, will be tested and optimized in the SPIDER source and MITICA full injector prototypes, using a set of diagnostics not available on the ITER HNB. The RF source, where the H{sup -}/D{sup -} production is enhanced by cesium evaporation, will be monitored with thermocouples, electrostatic probes, optical emission spectroscopy, cavity ring down, and laser absorption spectroscopy. The beam is analyzed by cooling water calorimetry, a short pulse instrumented calorimeter, beam emission spectroscopy, visible tomography, and neutron imaging. Design of the diagnostic systems is presented.

  14. The Booster Application Facility (BAF) Beam Transport Line of BNL-AGS Booster

    International Nuclear Information System (INIS)

    An experimental facility, to irradiate materials with energetic ion beams, has been proposed to be built at the Brookhaven National Laboratory. The BAF facility will mainly consist of the AGS-Booster slow extraction, of a beam transport line, and a target room. The beam transport line will transport the slow extracted beam of the AGS-Booster to the target location for the irradiation of various materials and specimens. A variety of ion beams like (p, 28Si, 56Fe, 63Cu, 197Au) in the energy range of 0.04 to 3.07 GeV/nucleon will be transported by the BAF line which is designed to provide variable beam spot sizes on the BAF target with sizes varying from 2.0 cm to 20.0 cm in diameter. The beam spot sizes will include 95% of the beam intensity with the beam distributed normally (Gaussian) on the target area. It is also possible by introducing magnetic octupoles at specified locations along the beam transport line, to modify the distribution on the BAF target and provide well confined beams with rectangular cross section and with uniform distribution on the target

  15. MedAustron - Ion-Beam Therapy and Research Center

    International Nuclear Information System (INIS)

    MedAustron is a synchrotron-based light-ion beam therapy center for cancer treatment as well as for clinical and non-clinical research, currently in the commissioning phase in Wiener Neustadt, Austria. Recently, the first proton beam was transported successfully to one of the four irradiation rooms. Whilst the choice of basic machine parameters was driven by medical requirements, i.e. 60 MeV protons and 120 MeV/A to 400 MeV/A carbon ions, the accelerator complex design was also optimized to offer flexibility for research operation. The potential of the synchrotron is being exploited to increase the maximum proton energy far beyond the medical needs to up to 800 MeV, for experimental physics applications, mainly in the areas of proton scattering and detector research. The accelerator layout allows for the installation of up to four ion source-spectrometer units, to provide various ion types besides the clinical used protons and carbon ions. Besides experimental physics, the two main non-clinical research disciplines are medical radiation physics and radiation biology. To decouple research and medical operation, a dedicated irradiation room for non-clinical research was included providing the installation of different experiments. In addition, several labs have been equipped with appropriate devices for preparing and analyzing radio-biological samples. This presentation gives a status overview over the whole project and highlights the non-clinical research opportunities at MedAustron. (Author)

  16. Electron beam therapy with coil-generated magnetic fields

    International Nuclear Information System (INIS)

    This paper presents an initial study on the issues involved in the practical implementation of the use of transverse magnetic fields in electron beam therapy. By using such magnetic fields the dose delivered to the tumor region can increase significantly relative to that deposited to the healthy tissue. Initially we calculated the magnetic fields produced by the Helmholtz coil and modified Helmholtz coil configurations. These configurations, which can readily be used to generate high intensity magnetic fields, approximate the idealized magnetic fields studied in our previous publications. It was therefore of interest to perform a detailed study of the fields produced by these configurations. Electron beam dose distributions for 15 MeV electrons were calculated using the ACCEPTM code for a 3T transverse magnetic field produced by the modified Helmholtz configuration. The dose distribution was compared to those obtained with no magnetic field. The results were similar to those obtained in our previous work, where an idealized step function magnetic field was used and a 3T field was shown to be the optimal field strength. A simpler configuration was also studied in which a single external coil was used to generate the field. Electron dose distributions are also presented for a given geometry and given magnetic field strength using this configuration. The results indicate that this method is more difficult to apply to radiotherapy due to its lack of symmetry and its irregularity. For the various configurations dealt with here, a major problem is the need to shield the magnetic field in the beam propagation volume, a topic that must be studied in detail

  17. Design of neutron beams for boron neutron capture therapy in a fast reactor

    International Nuclear Information System (INIS)

    The BNCT (Boron Neutron Capture Therapy) technique makes use of thermal or epithermal neutrons to irradiate tumours previously loaded with 10B. Reactors are currently seen as a suitable neutron source for BNCT implementation, due to the high intensity of the flux they can provide. The TAPIRO reactor, that is located at the ENEA Casaccia Centre near Rome, is a low-power fast-flux research reactor that can be usefully employed for this application. In this work computer simulations were carried out on this reactor to obtain epithermal and thermal neutron beams for the application of BNCT in Italy in the framework of a specific research program. Comparisons with measurements are also reported. Using the MCNP-4B code, Monte Carlo calculations were carried out to determine the materials suitable for the design of the thermal and epithermal columns. Various arrangements of reflector and moderator materials have been investigated to achieve the desired experimental constraints. On the basis of these calculations, a thermal column was designed and installed in the TAPIRO reactor to perform preliminary experiments on small laboratory animals. For the planning of a therapy treatment of gliomas on larger size animals, several material configurations were investigated in the search for an optimal epithermal facility. The aim of the present study is to indicate how a fast research reactor can be successfully modified for generating neutron beams suitable for BNCT applications. (author)

  18. The Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    The status of the new Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory (ORNL), which is slated to start its scientific program late this year is discussed, as is the new experimental equipment which is being constructed at this facility. Information on the early scientific program also is given

  19. The latest from the new Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    The status of new Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory (ORNL), which is slated to start its scientific program late in 1996 is discussed, as is the new experimental equipment which is being constructed at this facility. Information on the early scientific program is also given

  20. The Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Garrett, J.D. [Oak Ridge National Lab., TN (United States)

    1996-12-31

    The status of the new Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory (ORNL), which is slated to start its scientific program late this year is discussed, as is the new experimental equipment which is being constructed at this facility. Information on the early scientific program also is given.

  1. Study on beam geometry and image reconstruction algorithm in fast neutron computerized tomography at NECTAR facility

    International Nuclear Information System (INIS)

    Investigations on the fast neutron beam geometry for the NECTAR facility are presented. The results of MCNP simulations and experimental measurements of the beam distributions at NECTAR are compared. Boltzmann functions are used to describe the beam profile in the detection plane assuming the area source to be set up of large number of single neutron point sources. An iterative algebraic reconstruction algorithm is developed, realized and verified by both simulated and measured projection data. The feasibility for improved reconstruction in fast neutron computerized tomography at the NECTAR facility is demonstrated.

  2. The intensity feedback system at Heidelberg Ion-Beam Therapy Centre

    Energy Technology Data Exchange (ETDEWEB)

    Schoemers, Christian, E-mail: christian.schoemers@med.uni-heidelberg.de; Feldmeier, Eike; Naumann, Jakob; Panse, Ralf; Peters, Andreas; Haberer, Thomas

    2015-09-21

    At Heidelberg Ion-Beam Therapy Centre (HIT), more than 2500 tumour patients have been treated with charged particle beams since 2009 using the raster scanning method. The tumour is irradiated slice-by-slice, each slice corresponding to a different beam energy. For the particle dose of each raster point the pre-irradiation by more distal slices has to be considered. This leads to highly inhomogeneous dose distributions within one iso-energy slice. The particles are extracted from the synchrotron via transverse RF knock-out. A pure feed forward control cannot take into account fluence inhomogeneities or deal with intensity fluctuations. So far, fluctuations have been counteracted by a reduced scanning velocity. We now added a feedback loop to the extraction system. The dose monitoring ionisation chambers in front of the patient have been coupled to the extraction device in the synchrotron. Characterization and implementation of the intensity feedback system into the HIT facility is described here. By its implementation the treatment time has been reduced by 10% in average.

  3. Beam removal block and shielding resign for the MARS neutron therapy reactor

    International Nuclear Information System (INIS)

    The beam removal block and shielding design for the MARS neutron therapy reactor are described. The requirements to the beams' characteristics, filters, collimator and reactor shielding are formulated. Radiation field levels in medical box are analyzed for beams' different operation conditions. It is stated that the removal block and shutter compositions meet necessary conditions in radiation treatment and emergency evacuation

  4. Experimental program with beam in TESLA test facility

    International Nuclear Information System (INIS)

    In order to establish a technical basis for a high energy e+e- collider using the superconducting RF technology, the test of a string of 32 cavities with beam at an accelerating gradient of 15 MV/m is planned in an installation at DESY. Several experiments with beam in the TTF linac will be performed. The dissipated HOM power at helium temperature is a key issue for TESLA, its estimation requires careful calorimetric measurements and the full charge injector. Bunch wake potentials can be estimated with bunch charges of at least 1 to 2 nC. Multibunch measurements require a beam of a few hundreds of these bunches. The beam will be injected either on axis or off axis. RF steering due to couplers will be estimated by measuring the beam displacement for different RF phase settings. The expected resolution is well below the TESLA specification. The acceleration of dark currents will be observed for different settings of the focusing elements. 7 figs., 1 tab., 3 refs

  5. Upgrade of accelerator beam facilities and revitalization of the utilization

    International Nuclear Information System (INIS)

    Through this project, the quality of the research with the proton accelerator could be improved due to the construction of the sample radiation measurement system which monitor the radiation after proton beam irradiation and the optical properties analysis system which is necessary for the irradiated samples. The semiconductor ion implanter was moved to Gyungju PEFP from Daejeon and set up. The ion beam service was performed 95 times from August to November 30. Blue sapphire was made by the metal ion implanter so that the possibility for the mass production and the industrial application was certified. In addition, PCB drill durability enhancement research was performed in the various condition, which helps other research for the industrial parts, and the light catalyst research was also effective to the real products. The number of paper submission and acceptance exceeds the original plan and three patent are processing. The semiconductor ion implanter can provide the various metal ion beam, which is evaluated as a big outcome. We are planing to activate the use of the metal ion implanter, to increase the available metal ion beam after obtaining a budget, to collect some fee for ion beam service, to commercialize the blue and yellow sapphire, to apply the metal ion implanter for other sapphire coloring, to transfer the light catalyst technology to company after additional researches. For PCB drill which some companies notice about, we endeavor the possibility of commerce by evaluating the mass production and economic advantage

  6. ISAC and ARIEL the TRIUMF radioactive beam facilities and the scientific program

    CERN Document Server

    Krücken, Reiner; Merminga, Lia

    2014-01-01

    The TRIUMF Isotope Separator and Accelerator (ISAC) facility uses the isotope separation on-line (ISOL) technique to produce rare-isotope beams (RIB). The ISOL system consists of a primary production beam, a target/ion source, a mass separator, and beam transport system. The rare isotopes produced during the interaction of the proton beam with the target nucleus are stopped in the bulk of the target material. They diffuse inside the target material matrix to the surface of the grain and then effuse to the ion source where they are ionized to form an ion beam that can be separated by mass and then guided to the experimental facilities. Previously published in the journal Hyperfine Interactions.

  7. The Final Beam Line Design for the HiRadMat Test Facility

    CERN Document Server

    Hessler, C; Meddahi, M

    2010-01-01

    The High Radiation to Materials facility - hereafter HiRadMat - is designed to allow testing of accelerator components, in particular those of the LHC and its injectors, with the impact of high-intensity pulsed beams. The facility is currently under construction, as an approved CERN project. The installation of the dedicated primary beam line and experimental area is planned during the 2010-2011 technical stop. It will be ready for users after commissioning and some test running in October 2011. A detailed proton beam line design has been performed in order to fulfil the beam parameter specification, in particular the demanding optics flexibility at the test stand location. The studies presented include trajectory correction and aperture studies as well as specifications of magnetic systems, power converters, beam instrumentation and vacuum systems

  8. Hadron-therapy beam monitoring: Towards a new generation of ultra-thin p-type silicon strip detectors

    International Nuclear Information System (INIS)

    Hadron-therapy has gained increasing interest for cancer treatment especially within the last decade. System commissioning and quality assurance procedures impose to monitor the particle beam using 2D dose measurements. Nowadays, several monitoring systems exist for hadron-therapy but all show a relatively high influence on the beam properties: indeed, most devices consist of several layers of materials that degrade the beam through scattering and energy losses. For precise treatment purposes, ultra-thin silicon strip detectors are investigated in order to reduce this beam scattering. We assess the beam size increase provoked by the Multiple Coulomb Scattering when passing through Si, to derive a target thickness. Monte-Carlo based simulations show a characteristic scattering opening angle lower than 1 mrad for thicknesses below 20 μm. We then evaluated the fabrication process feasibility. We successfully thinned down silicon wafers to thicknesses lower than 10 μm over areas of several cm2. Strip detectors are presently being processed and they will tentatively be thinned down to 20 μm. Moreover, two-dimensional TCAD simulations were carried out to investigate the beam detector performances on p-type Si substrates. Additionally, thick and thin substrates have been compared thanks to electrical simulations. Reducing the pitch between the strips increases breakdown voltage, whereas leakage current is quite insensitive to strips geometrical configuration. The samples are to be characterized as soon as possible in one of the IBA hadron-therapy facilities. For hadron-therapy, this would represent a considerable step forward in terms of treatment precision. (authors)

  9. ANURIB – Advanced National facility for Unstable and Rare Ion Beams

    Indian Academy of Sciences (India)

    Arup Bandyopadhyay; V Naik; S Dechoudhury; M Mondal; A Chakrabarti

    2015-09-01

    An ISOL post-accelerator type of RIB facility is being developed at Variable Energy Cyclotron Centre (VECC), Kolkata, India. In this scheme, Rare Ion Beams (RIBs) will be produced using light ion beams (, ) from the = 130 cyclotron, the RIB of interest will be separated from the other reaction products and accelerated up to about 2 MeV/u using a number of linear accelerators. Recently, a few RIBs have been produced and accelerated using this facility. As an extention of this effort, another RIB facility – ANURIB will be developed in a new campus as a green-field project. ANURIB will have two driver accelerators – a superconducting electron LINAC to produce n-rich RIBs using photofission route and a 50 MeV proton cyclotron for producing p-rich RIBs. In this paper, the status of the RIB facility in the present campus and future plans with the ANURIB facility will be discussed.

  10. Optics calculations and beam line design for the JANNuS facility in Orsay

    Energy Technology Data Exchange (ETDEWEB)

    Chauvin, N. [Centre de Spectrometrie Nucleaire et de Spectrometrie de Masse, CNRS/IN2P3, Univ Paris-Sud, UMR8609, ORSAY-Campus F-91405 (France)]. E-mail: chauvin@csnsm.in2p3.fr; Henry, S. [Centre de Spectrometrie Nucleaire et de Spectrometrie de Masse, CNRS/IN2P3, Univ Paris-Sud, UMR8609, ORSAY-Campus F-91405 (France); Flocard, H. [Centre de Spectrometrie Nucleaire et de Spectrometrie de Masse, CNRS/IN2P3, Univ Paris-Sud, UMR8609, ORSAY-Campus F-91405 (France); Fortuna, F. [Centre de Spectrometrie Nucleaire et de Spectrometrie de Masse, CNRS/IN2P3, Univ Paris-Sud, UMR8609, ORSAY-Campus F-91405 (France); Kaitasov, O. [Centre de Spectrometrie Nucleaire et de Spectrometrie de Masse, CNRS/IN2P3, Univ Paris-Sud, UMR8609, ORSAY-Campus F-91405 (France); Pariset, P. [Centre de Spectrometrie Nucleaire et de Spectrometrie de Masse, CNRS/IN2P3, Univ Paris-Sud, UMR8609, ORSAY-Campus F-91405 (France); Pellegrino, S. [INSTN, CEA-Saclay, 91191 Gif-sur-Yvette Cedex (France); Ruault, M.O. [Centre de Spectrometrie Nucleaire et de Spectrometrie de Masse, CNRS/IN2P3, Univ Paris-Sud, UMR8609, ORSAY-Campus F-91405 (France); Serruys, Y. [CEA-Saclay, DEN/DMN/SRMP, 91191 Gif-sur-Yvette Cedex (France); Trocelier, P. [CEA-Saclay, DEN/DMN/SRMP, 91191 Gif-sur-Yvette Cedex (France)

    2007-08-15

    JANNuS (Joint Accelerators for Nano-Science and Nuclear Simulation) will be a unique user facility in Europe dedicated to material modification by ion beam implantation and irradiation. The main originality of the project is that it will be possible to perform implantation and irradiation with simultaneous multiple ions beams and in situ characterization by transmission electron microscopy (TEM) observation or ion beam analysis. This facility will be composed of two experimental platforms located in two sites: the CEA-SRMP in Saclay and the CNRS-CSNSM in Orsay. This paper will focus on the design of two new transport beam lines for the Orsay site. One of the most challenging parts of the JANNuS project (Orsay site) is to design two new beam lines in order to inject, into a 200 kV TEM, two different ion beams (low and medium energy) coming from two existing pieces of equipment: a 2 MV Tandem accelerator and a 190 kV ion implanter. For these new beam lines, first order beam calculations have been done using transfer matrix formalism. A genetic algorithm has been written and adapted to perform the optimization of the beam line parameters. Then, using the SIMION code, field maps of the electrostatic elements (quadrupoles, spherical sectors) have been calculated and ion trajectories have been simulated. We studied specifically the optical aberrations induced by the electrostatic spherical deflectors. Finally, the results of the first order calculations and the field map simulations show a good agreement.

  11. Production of low-Z ions in the Dresden superconducting electron ion beam source for medical particle therapy

    International Nuclear Information System (INIS)

    We report on experiments with a new superconducting electron beam ion source (EBIS-SC), the Dresden EBIS-SC, with the objective to meet the main requirements for their application in particle-therapy facilities. Synchrotrons as well as innovative accelerator concepts, such as high-gradient linacs which are driven by a large-current cyclotron (CYCLINACS) and direct drive RF linear accelerators may benefit from the advantages of EBISs in regard to their functional principle. First experimental studies of the production of low-Z ions such as H+, H2+, H3+, C4+, and C6+ are presented. Particular attention is paid to the ion output, i.e., the number of ions per pulse and per second, respectively. Important beam parameters in this context are, among others, ion pulse shaping, pulse repetition rates, beam emittance, and ion energy spread.

  12. Commissioning experience and beam physics measurements at the SwissFEL Injector Test Facility

    CERN Document Server

    Schietinger, T; Aiba, M; Arsov, V; Bettoni, S; Beutner, B; Calvi, M; Craievich, P; Dehler, M; Frei, F; Ganter, R; Hauri, C P; Ischebeck, R; Ivanisenko, Y; Janousch, M; Kaiser, M; Keil, B; Löhl, F; Orlandi, G L; Loch, C Ozkan; Peier, P; Prat, E; Raguin, J -Y; Reiche, S; Schilcher, T; Wiegand, P; Zimoch, E; Anicic, D; Armstrong, D; Baldinger, M; Baldinger, R; Bertrand, A; Bitterli, K; Bopp, M; Brands, H; Braun, H H; Brönnimann, M; Brunnenkant, I; Chevtsov, P; Chrin, J; Citterio, A; Divall, M Csatari; Dach, M; Dax, A; Ditter, R; Divall, E; Falone, A; Fitze, H; Geiselhart, C; Guetg, M W; Hämmerli, F; Hauff, A; Heiniger, M; Higgs, C; Hugentobler, W; Hunziker, S; Janser, G; Kalantari, B; Kalt, R; Kim, Y; Koprek, W; Korhonen, T; Krempaska, R; Laznovsky, M; Lehner, S; Pimpec, F Le; Lippuner, T; Lutz, H; Mair, S; Marcellini, F; Marinkovic, G; Menzel, R; Milas, N; Pal, T; Pollet, P; Portmann, W; Rezaeizadeh, A; Ritt, S; Rohrer, M; Schär, M; Schebacher, L; Scherrer, St; Schmidt, V Schlott T; Schulz, L; Smit, B; Stadler, M; Steffen, B; Stingelin, L; Sturzenegger, W; Treyer, D M; Trisorio, A; Tron, W; Vicario, C; Zennaro, R; Zimoch, D

    2016-01-01

    The SwissFEL Injector Test Facility operated at the Paul Scherrer Institute between 2010 and 2014, serving as a pilot plant and testbed for the development and realization of SwissFEL, the X-ray Free-Electron Laser facility under construction at the same institute. The test facility consisted of a laser-driven rf electron gun followed by an S-band booster linac, a magnetic bunch compression chicane and a diagnostic section including a transverse deflecting rf cavity. It delivered electron bunches of up to 200 pC charge and up to 250 MeV beam energy at a repetition rate of 10 Hz. The measurements performed at the test facility not only demonstrated the beam parameters required to drive the first stage of an FEL facility, but also led to significant advances in instrumentation technologies, beam characterization methods and the generation, transport and compression of ultra-low-emittance beams. We give a comprehensive overview of the commissioning experience of the principal subsystems and the beam physics meas...

  13. Nuclear Astrophysics Data from Radioactive Beam Facilities. Final report

    International Nuclear Information System (INIS)

    The scientific aims of this project have been the evaluation and dissemination of key nuclear reactions in nuclear astrophysics, with a focus on ones to be studied at new radioactive beam facilities worldwide. These aims were maintained during the entire funding period from 2003 - 2006. In the following, a summary of the reactions evaluated during this period is provided. Year 1 (2003-04): 21Na(p,γ)22Mg and 18Ne(α,p)21Na - The importance of the 21Na(p,γ)22Mg and the 18Ne(α,p)21Na reactions in models of exploding stars has been well documented: the first is connected to the production of the radioisotope 22Na in nova nucleosynthesis, while the second is a key bridge between the Hot-CNO cycles and the rp-process in X-ray bursts. By the end of Summer 2004, our group had updated these reaction rates to include all published data up to September 2004, and cast the reaction rates into standard analytical and tabular formats with the assistance of Oak Ridge National Laboratory's computational infrastructure for reaction rates. Since September 2004, ongoing experiments on these two reactions have been completed, with our group's participation in both: 21Na(p,γ)22Mg at the TRIUMF-ISAC laboratory (DRAGON collaboration), and 18Ne(α,p)21Na at Argonne National Laboratory (collaboration with Ernst Rehm, Argonne). The data from the former was subsequently published and included in our evaluation. Publication from the latter still awaits independent confirmation of the experimental results. Year 2 (2004-05): The 25Al(p,γ)26Si and 13N(p,γ)14O reactions - For Year 2, we worked on evaluations of the 25Al(p,γ)26Si and 13N(p,γ)14O reactions, in accordance with our proposed deliverables and following similar standard procedures to those used in Year 1. The 25Al(p,γ)26Si reaction is a key uncertainty in the understanding the origin of galactic 26Al, a target radioisotope for gamma ray astronomy; the 13N(p,γ)14O reaction in turn is the trigger reaction for the transition into

  14. Performance and beam characteristics of the PANTAK THERAPAX HF225 X-ray therapy machine

    International Nuclear Information System (INIS)

    The performance and beam characteristics of the new PANTAK THERAPAX HF225 X-ray therapy machine have been measured, evaluated and discussed. Eight beam qualities within the working range of generating potentials between 50 and 225 kVp are used in our department. These beam qualities have been investigated in order to provide a data base specific to our machine. Beam Quality, Central Axis Depth Dose, Output, Relative Field Uniformity and Timer Error were investigated. (authors)

  15. The CBS-The Most Cost Effective and High Performance Carbon Beam Source Dedicated for a New Generation Cancer Therapy

    CERN Document Server

    Kumada, Masayuki; Leivichev, E B; Parkhomchuk, Vasily; Podgorny, Fedor; Rastigeev, Sergey; Reva, Vladimir B; Skrinsky, Aleksander Nikolayevich; Vostrikov, Vladimir

    2005-01-01

    A Carbon ion beam is a superior tool to x-rays or a proton beam in both physical and biological doses in treating a cancer. A Carbon beam has an advantage in treating radiation resistant and deep-seated tumors. Its radiological effect is of a mitotic independent nature. These features improve hypofractionation, typically reducing the number of irradiations per patient from 35 to a few. It has been shown that a superior QOL(Quality Of Life) therapy is possible by a carbon beam.The only drawback is its high cost. Nevertheless, tens of Prefectures and organizations are eagerly considering the possibility of having a carbon ion therapy facility in Japan. Germany, Austria, Italy, China, Taiwan and Korea also desire to have one.A carbon beam accelerator of moderate cost is about 100 Million USD. With the "CBS" design philosophy, which will be described in this paper, the cost could be factor of 2 or 3 less, while improving its performance more than standard designs. Novel extraction techniques, a new approach to a ...

  16. Design of a medical reactor generating high quality neutron beams for boron neutron capture therapy

    International Nuclear Information System (INIS)

    Boron neutron capture therapy (BNCT) is a binary treatment modality that can selectively irradiate tumor tissue. BNCT uses drugs containing a stable isotope of boron, B-10, that are capable of preferentially accumulating in the tumor, which is then irradiated with thermal neutrons. The interaction of the B-10 with a thermal neutron causes the B-10 nucleus to split, releasing an alpha particle and a lithium nucleus. These products of the boron neutron capture reaction are very damaging to cells but have a path length in tissue of approximately 14 micrometers, or roughly the diameter of one or two cells. Thus, most of the ionizing energy imparted to tissue is localized to B-10-loaded cells. Since the early 1980s, there have been considerable improvements in boron compounds and neutron beams. More is known now about the radiation biology of BNCT, which has reemerged as a potentially useful method for preferential irradiation of tumors. Clinical trials have been initiated at BNL and MIT, with an improved boron compound and epithermal neutrons. At this time, nuclear reactors are the only demonstrated satisfactory sources of epithermal neutrons. While some reactors are available and within reach of cancer treatment centers, a question arises as to the feasibility and practicality of placing new epithermal neutron sources in hospitals. In this thesis, we design a square reactor (that can easily be reconfigured into polygonal reactors as the need arises) with four slab type assemblies to produce two epithermal neutron beams and two thermal neutron beams for use in neutron capture therapy. This square reactor with four large-area faces consists of 1056 U3Si-Al fuel elements and 36 B4C control rods. The proposed facility, based on this square reactor core with a maximum operating power of 300kW, provides an epithermal neutron beam of 3.2x109 nepi/cm2 · s intensity with low contamination by fast neutrons (<1.6x10-13 Gy · cm2/nepi) and gamma rays (<1.0x10-13 Gy · cm2/nepi

  17. Development of a Tandem-ElectroStatic-Quadrupole accelerator facility for Boron Neutron Capture Therapy (BNCT)

    International Nuclear Information System (INIS)

    There is a generalized perception that the availability of suitable particle accelerators installed in hospitals, as neutron sources, may be crucial for the advancement of Boron Neutron Capture Therapy (BNCT). An ongoing project to develop a Tandem-ElectroStatic-Quadrupole (TESQ) accelerator facility for Accelerator-Based (AB)-BNCT is described here. The project goal is a machine capable of delivering 30 mA of 2.4-2.5 MeV protons to be used in conjunction with a neutron production target based on the 7Li(p,n)7Be reaction slightly beyond its resonance at 2.25 MeV. A folded tandem, with 1.20-1.25 MV terminal voltage, combined with an ESQ chain is being designed and constructed. This machine is conceptually shown to be capable of accelerating a 30 mA proton beam to 2.5 MeV. These are the specifications needed to produce sufficiently intense and clean epithermal neutron beams, based on the 7Li(p,n)7Be reaction, to perform BNCT treatment for deep-seated tumors in less than an hour. This electrostatic machine is one of the technologically simplest and cheapest solutions for optimized AB-BNCT. At present there is no BNCT facility in the world with the characteristics presented in this work. For the accelerator, results on its design, construction and beam transport calculations are discussed. Taking into account the peculiarities of the expected irradiation field, the project also considers a specific study of the treatment room. This study aims at the design of the treatment room emphasizing aspects related to patient, personnel and public radiation protection; dose monitoring; patient positioning and room construction. The design considers both thermal (for the treatment of shallow tumors) and epithermal (for deep-seated tumors) neutron beams entering the room through a port connected to the accelerator via a moderation and neutron beam shaping assembly. Preliminary results of dose calculations for the treatment room design, using the MCNP program, are presented

  18. Combined microwave and electron beam exposure facilities for medical studies and applications.

    Science.gov (United States)

    Martin, Diana; Cinca, Sabin; Margaritescu, Irina; Neagu, Monica; Iacob, Nicusor; Ighigeanu, Daniel; Matei, Constantin; Craciun, Gabriela; Manaila, Elena; Chirita, Doru Aurel; Moisescu, Mihaela

    2009-01-01

    The paper presents two radiation exposure facilities (REFs) which permit separate and simultaneous irradiation with microwaves (MW) of 2.45 GHz and electron beams (EB) of 6.23 MeV for malignant melanoma (MM) cell investigations, in vitro (MW+EB-REF-vitro) and in vivo (MW+EB-REF-vivo). The REFs are specifically designed for the following medical studies: 1) The effects of separate and combined (successive and simultaneous) MW and EB irradiation on the B16F10 mouse--MM cell cultures without/with drugs incubation, 2) The effects of separate and combined MW and EB irradiation on human blood components irradiated in samples of integral blood from healthy donors and from donors with MM; 3) The effects of separate and combined MW and EB whole body irradiation on the C57 BL/6 mice bearing MM without/with drugs administration. Several representative results obtained by experiments with REFs in vitro and in vivo are discussed. The most important conclusion of the experimental results is that low dose-total body MW+EB irradiation combined with drugs administration could present a valuable potential for an advanced study in malignant melanoma therapy. PMID:21384705

  19. 3D printed plastics for beam modulation in proton therapy

    International Nuclear Information System (INIS)

    Two 3D printing methods, fused filament fabrication (FFF) and PolyJet™ (PJ) were investigated for suitability in clinical proton therapy (PT) energy modulation. Measurements of printing precision, printed density and mean stopping power are presented. FFF is found to be accurate to 0.1 mm, to contain a void fraction of 13% due to air pockets and to have a mean stopping power dependent on geometry. PJ was found to print accurate to 0.05 mm, with a material density and mean stopping power consistent with solid poly(methyl methacrylate) (PMMA). Both FFF and PJ were found to print significant, sporadic defects associated with sharp edges on the order of 0.2 mm. Site standard PT modulator wheels were printed using both methods. Measured depth-dose profiles with a 74 MeV beam show poor agreement between PMMA and printed FFF wheels. PJ printed wheel depth-dose agreed with PMMA within 1% of treatment dose except for a distal falloff discrepancy of 0.5 mm. (note)

  20. Neutron Beam Characterization for Neutron Radiography Facility at the Thai Research Reactor TRR-1/M1

    International Nuclear Information System (INIS)

    The aim of this research is to characterize the present status of neutron beam coming out from the reactor core of Thai Research Reactor TRR-1/M1 through neutron radiography facility. In this study, the neutron beam profiles at different positions along the beam exit were recorded using digital imaging devices. In addition, thin foil activation technique, with and without cadmium cover, was employed to determine thermal neutron flux and Cd ratio. An acrylic step wedge was exposed to neutron at different time. In parallel to image construction, neutron detection was carried out using a BF3 gas-filled detector. Then, the image intensities at particular thicknesses were normalized by neutron counts from the BF3 detector to determine relative neutron intensity. The obtained information of neutron beam characterization will be useful not only for monitoring the present status of neutron radiography facility but also for determining the optimum exposure conditions for particular samples in the future.

  1. Construction of the SCRIT electron scattering facility at the RIKEN RI Beam Factory

    Science.gov (United States)

    Wakasugi, M.; Ohnishi, T.; Wang, S.; Miyashita, Y.; Adachi, T.; Amagai, T.; Enokizono, A.; Enomoto, A.; Haraguchi, Y.; Hara, M.; Hori, T.; Ichikawa, S.; Kikuchi, T.; Kitazawa, R.; Koizumi, K.; Kurita, K.; Miyamoto, T.; Ogawara, R.; Shimakura, Y.; Takehara, H.; Tamae, T.; Tamaki, S.; Togasaki, M.; Yamaguchi, T.; Yanagi, K.; Suda, T.

    2013-12-01

    The SCRIT electron scattering facility, aiming at electron scattering off short-lived unstable nuclei, has been constructed at the RIKEN RI Beam Factory. This facility consists of a racetrack microtron (RTM), an electron storage ring (SR2) equipped with the SCRIT system, and a low-energy RI separator (ERIS). SCRIT (self-confining radioactive isotope ion targeting) is a novel technique to form internal targets in an electron storage ring. Experiments for evaluating performance of the SCRIT system have been carried out using the stable 133Cs1+ beam and the 132Xe1+ beam supplied from ERIS. Target ions were successfully trapped in the SCRIT system with 90% efficiency at a 250 mA electron beam current, and luminosity exceeding 1026/(cm2 s) was maintained for more than 1 s. Electrons elastically scattered from the target ions were successfully measured. Applicability of the SCRIT system to electron scattering for unstable nuclei has been established in experiments.

  2. The new external beam facility of the Oxford scanning proton microprobe

    International Nuclear Information System (INIS)

    This paper describes the development of a high spatial resolution external beam facility on one of the beamlines of the Oxford scanning proton microprobe tandem accelerator. Using a magnetic quadrupole doublet to focus the beam through the Kapton exit window a beam diameter of <50 μm full width at half maximum (fwhm) can be achieved on a sample located at 4 mm from the exit window. The facility is equipped with two Si-Li X-ray detectors for proton-induced X-ray emission (PIXE) analysis of light and trace elements respectively, a surface barrier detector for Rutherford backscattering spectrometry (RBS) analysis and a HP-Ge detector for γ-ray detection. The mechanical and beam-optical design of the system is described

  3. A Micromegas Detector for Neutron Beam Imaging at the n_TOF Facility at CERN

    CERN Document Server

    Belloni, F; Berthoumieux, E; Calviani, M; Chiaveri, E; Colonna, N; Giomataris, Y; Guerrero, C; Gunsing, F; Iguaz, F J; Kebbiri, M; Pancin, J; Papaevangelou, T; Tsinganis, A; Vlachoudis, V; Altstadt, S; Andrzejewski, J; Audouin, L; Barbagallo, M; Bécares, V; Bečvář, F; Billowes, J; Boccone, V; Bosnar, D; Brugger, M; Calviño, F; Cano-Ott, D; Carrapiço, C; Cerutti, F; Chiaveri, E; Chin, M; Cortés, G; Corté-Giraldo, M A; Diakaki, M; Domingo-Pardo, C; Duran, I; Dzysiuk, N; Eleftheriadis, C; Ferrari, A; Fraval, K; Ganesan, S; García, A R; Giubrone, G; Gómez-Hornillos, M B; Gonçalves, I F; González-Romero, E; Griesmayer, E; Gurusamy, P; Jenkins, D G; Jericha, E; Kadi, Y; Käppeler, F; Karadimos, D; Koehler, P; Kokkoris, M; Krtička, M; Kroll, J; Langer, C; Lederer, C; Leeb, H; Leong, L S; Losito, R; Manousos, A; Marganiec, J; Marítnez, T; Massimi, C; Mastinu, P F; Mastromarco, M; Meaze, M; Mendoza, E; Mengoni, A; Milazzo, P M; Mingrone, F; Mirea, M; Mondalaers, W; Paradela, C; Pavlik, A; Perkowski, J; Plompen, A J M; Praena, J; Quesada, J M; Rauscher, T; Reifarth, R; Riego, A; Roman, F; Rubbia, C; Sarmento, R; Schillebeeckx, P; Schmidt, S; Tagliente, G; Tain, J L; Tarrío, D; Tassan-Got, L; Valenta, S; Vannini, G; Variale, V; Vaz, P; Ventura, A; Versaci, R; Vermeulen, M J; Vlastou, R; Wallner, A; Ware, T; Weigand, M; Weiss, C; Wright, T J; Žugec, P

    2014-01-01

    Micromegas (Micro-MEsh Gaseous Structure) detectors are gas detectors consisting of a stack of one ionization and one proportional chamber. A micromesh separates the two communicating regions, where two different electric fields establish respectively a charge drift and a charge multiplication regime. The n\\_TOF facility at CERN provides a white neutron beam (from thermal up to GeV neutrons) for neutron induced cross section measurements. These measurements need a perfect knowlodge of the incident neutron beam, in particular regarding its spatial profile. A position sensitive micromegas detector equipped with a B-10 based neutron/charged particle converter has been extensively used at the n\\_TOF facility for characterizing the neutron beam profile and extracting the beam interception factor for samples of different size. The boron converter allowed to scan the energy region of interest for neutron induced capture reactions as a function of the neutron energy, determined by the time of flight. Experimental ...

  4. Development of modulated electron beam for intensity modulated radiation therapy (IMRT) on a photocathode electron gun

    International Nuclear Information System (INIS)

    Radiation therapy of cancer is developing to un-uniform irradiation, for concentrating dose to a cancer tumor and reducing dose to normal tissue. As a step toward the Intensity modulated radiation therapy, we examined dynamic optical modulation of electron beam produced by a photocathode electron gun. Images on photo-masks were transferred onto a photocathode by relay imaging. Electron beam could be controlled by a remote mirror. Modulated electron beam maintained its shape on acceleration, had a fine spatial resolution, and could be moved dynamically by optical methods. As a second step, optical modulation of electron beam and dynamic control succeeded by a digital micro mirror device (DMD). (author)

  5. Beam dynamics studies in the driver LINAC pre-stripper section of the RIA facility

    Indian Academy of Sciences (India)

    E S Lessner; P N Ostroumov

    2002-12-01

    The RIA facility driver LINAC consists of about 400 superconducting (SC) independently phased rf cavities. The LINAC is designed to accelerate simultaneously several charge-state beams to generate as much as 400 kW of uranium beam power. The LINAC beam dynamics is most sensitive to the focusing and accelerating structure parameters of the pre-stripper section, where the uranium beam is accelerated from 0.17 keV/u to 9.4 MeV/u. This section is designed to accept and accelerate two charge states (28 and 29) of uranium beam from an ECR ion source. The pre-stripper section must be designed to minimize the beam emittance distortion of this two-charge-state beam. In particular, the inter-cryostat spaces must be minimized and beam parameters near transitions of the accelerating and focusing lattices must be matched carefully. Several sources of possible effective emittance growth are considered in the design of the pre-stripper section and a tolerance budget is established. Numerical beam dynamics studies include realistic electric and magnetic three-dimensional field distributions in the SC rf cavities and SC solenoids. Error effects in the longitudinal beam parameters are studied.

  6. A proposal of particle beam engineering in some 100 MeV energy field used beam line of accelerator-driven transmutation experimental facility

    International Nuclear Information System (INIS)

    To develop the researches of particle beam engineering in the middle energy field, construction of 'particle beam engineering experimental device' in the nuclear transmutation physics experimental facility of the High-Intensity Proton Accelerator Facility was investigated and proposed. The basis of proposal is experiments using short pulse proton beam (<1ns) produced by laser charge exchange method and construction of two targets: one is the low power target (10 W) for proton beam experiments and other the high power target (1kW) for neutron induced reaction experiments. This facility consists of target chamber, target exchange device, beam dump, some neutron TOF lines. This facility pressed forward the important experiments in the middle energy field such as basic data of proton and neutron in the nuclear transmutation physics and engineering, effects and elementary process of cosmic radiation, basic test of application of particle beam to medical treatment and development and characteristics test of detector. (S.Y.)

  7. Automatic beam position control at Los Alamos Spallation Radiation Effects Facility (LASREF)

    International Nuclear Information System (INIS)

    Historically the Los Alamos Spallation Radiation Effects Facility (LASREF) has used manual methods to control the position of the 800 kW, 800 MeV proton beam on targets. New experiments, however, require more stringent position control more frequently than can be done manually for long periods of time. Data from an existing harp is used to automatically adjust steering magnets to maintain beam position to required tolerances

  8. Expanded beam x-ray optics calibration facility at the Daresbury Synchrotron

    DEFF Research Database (Denmark)

    Christensen, Finn Erland; Hornstrup, Allan; FREDERIKSEN, P; ABDALI, S; Grundsøe, Peter; SCHNOPPER, HW; LEWIS, R; HALL, CH; BOROZDIN, K

    1994-01-01

    interval from 6 kev to 12 kev, the facility features a 1D sheet of X-rays, approximately 200 mm wide, obtained from an extremely asymmetric reflection in large perfect crystals of Si. The beam is collimated to < 20 arcsec. Data from tests using large (approximately 250 mm long) beam expander crystals in...... the energy range from 6 - 12 kev are presented. The planned calibration of the two X-ray telescopes (XSPECT/SODART and JET-X) will be described....

  9. Project of an advanced ISOL facility for exotic beams at LNL

    International Nuclear Information System (INIS)

    In the framework of the European program to define a second generation Radioactive Ion Beam facility, LNL are proposing the construction in the next five-seven years of a specialized national facility for RIB originated by fission fragments produced by secondary neutrons. It consists on a two-accelerator ISOL-type facility to provide intense neutron-rich radioactive ion beams of highest quality, in the range of masses between 80 and 160. The conceptual design is based on a high intensity 50 MeV (100 kW) proton linac as driver and on the availability of the heavy-ion accelerator ALPI as post accelerator. The estimated neutron yield is 2x1014 n/s at 0 deg., high enough to satisfy the demand for an advanced RIB facility. An intense R and D program on different items is actually in progress in collaboration with other Laboratories and University groups and is moving in a European context

  10. Structural design of beam transport system in SGIII facility target area

    International Nuclear Information System (INIS)

    Graphical abstract: - Highlights: • SGIII target area beam transport system claims stability, accuracy and cleanliness. • Vibrational stability of mirrors and laser beams is mainly analyzed. • The accuracy relies on adjustable kinematic mounts and low-stress clamping. • The cleanliness is established in structural design, fabrication and operation. - Abstract: Beam transport system in ShenGuangIII (SGIII) facility target area brings 48 laser beams from main laser output to final optics assemblies (FOAs). This paper will present a summary of structural design of SGIII target area beam transport system, which include 276 transport mirrors and nearly 3000 m beam enclosures. The key performance of the beam transport system structural design includes stability, accuracy and cleanliness. To ensure the vibrational stability requirement, the beam transport system is located on stable platforms comprised of switchyard steel space frame and experimental area steel reinforced concrete building. The high fundamental frequency of the transport mirror system and vibrational isolation from thin tubes are designed to decrease the vibration response of the mirrors. An analytical method is proposed to evaluate the structural design on the drifting error of each laser beam obtained by accounting the dynamic responses of each optical elements of laser beam. The adjusting and fast replacement online requirements are satisfied by the structural design of line replaceable units (LRUs), the adjustable kinematic mounts, and the low-stress clamping of mirror mounts. The cleanliness is established in the process of designing, fabrication, and operation simultaneously. Testing results of the beam transport system that has been installed indicate that the structural design satisfies the performance requirements of the facility

  11. Target irradiation facility and targetry development at 160 MeV proton beam of Moscow linac

    CERN Document Server

    Zhuikov, B L; Konyakhin, N A; Vincent, J

    1999-01-01

    A facility has been built and successfully operated with the 160 MeV proton beam of Moscow Meson factory LINAC, Institute for Nuclear Research (INR) of Russian Academy of Science, Troitsk. The facility was created for various isotope production goals as well as for fundamental nuclear investigations at high intensity beam (100 mu A and more). An important part of the facility targetry system is a high-intensity beam monitoring collimator device. Measurements of the temperature distribution between collimator sectors, cooling water flow and temperature, and the beam current, provide an opportunity to compute beam losses and beam position. The target holder design allows easy insertion by manipulator and simultaneous bombardment of several different targets of various types and forms, and variation of proton energy on each target over a wide range below 160 MeV. The main target utilized for commercial sup 8 sup 2 Sr isotope production is metallic rubidium in a stainless-steel container. A regular wet chemistry ...

  12. Proton Beam Therapy and Concurrent Chemotherapy for Esophageal Cancer

    International Nuclear Information System (INIS)

    Purpose: Proton beam therapy (PBT) is a promising modality for the management of thoracic malignancies. We report our preliminary experience of treating esophageal cancer patients with concurrent chemotherapy (CChT) and PBT (CChT/PBT) at MD Anderson Cancer Center. Methods and Materials: This is an analysis of 62 esophageal cancer patients enrolled on a prospective study evaluating normal tissue toxicity from CChT/PBT from 2006 to 2010. Patients were treated with passive scattering PBT with two- or three-field beam arrangement using 180 to 250 MV protons. We used the Kaplan-Meier method to assess time-to-event outcomes and compared the distributions between groups using the log–rank test. Results: The median follow-up time was 20.1 months for survivors. The median age was 68 years (range, 38–86). Most patients were males (82%) who had adenocarcinomas (76%) and Stage II-III disease (84%). The median radiation dose was 50.4 Gy (RBE [relative biologic equivalence]) (range, 36–57.6). The most common grade 2 to 3 acute toxicities from CChT/PBT were esophagitis (46.8%), fatigue (43.6%), nausea (33.9%), anorexia (30.1%), and radiation dermatitis (16.1%). There were two cases of grade 2 and 3 radiation pneumonitis and two cases of grade 5 toxicities. A total of 29 patients (46.8%) received preoperative CChT/PBT, with one postoperative death. The pathologic complete response (pCR) rate for the surgical cohort was 28%, and the pCR and near CR rates (0%–1% residual cells) were 50%. While there were significantly fewer local-regional recurrences in the preoperative group (3/29) than in the definitive CChT/PBT group (16/33) (log–rank test, p = 0.005), there were no differences in distant metastatic (DM)-free interval or overall survival (OS) between the two groups. Conclusions: This is the first report of patients treated with PBT/CChT for esophageal cancer. Our data suggest that this modality is associated with a few severe toxicities, but the pathologic response and

  13. Proton Beam Therapy and Concurrent Chemotherapy for Esophageal Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Steven H., E-mail: shlin@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Komaki, Ritsuko; Liao Zhongxing [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wei, Caimiao [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Myles, Bevan [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Guo Xiaomao [Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai (China); Palmer, Matthew [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe [Department of Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Swisher, Stephen G.; Hofstetter, Wayne L. [Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Ajani, Jaffer A. [Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Cox, James D. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2012-07-01

    Purpose: Proton beam therapy (PBT) is a promising modality for the management of thoracic malignancies. We report our preliminary experience of treating esophageal cancer patients with concurrent chemotherapy (CChT) and PBT (CChT/PBT) at MD Anderson Cancer Center. Methods and Materials: This is an analysis of 62 esophageal cancer patients enrolled on a prospective study evaluating normal tissue toxicity from CChT/PBT from 2006 to 2010. Patients were treated with passive scattering PBT with two- or three-field beam arrangement using 180 to 250 MV protons. We used the Kaplan-Meier method to assess time-to-event outcomes and compared the distributions between groups using the log-rank test. Results: The median follow-up time was 20.1 months for survivors. The median age was 68 years (range, 38-86). Most patients were males (82%) who had adenocarcinomas (76%) and Stage II-III disease (84%). The median radiation dose was 50.4 Gy (RBE [relative biologic equivalence]) (range, 36-57.6). The most common grade 2 to 3 acute toxicities from CChT/PBT were esophagitis (46.8%), fatigue (43.6%), nausea (33.9%), anorexia (30.1%), and radiation dermatitis (16.1%). There were two cases of grade 2 and 3 radiation pneumonitis and two cases of grade 5 toxicities. A total of 29 patients (46.8%) received preoperative CChT/PBT, with one postoperative death. The pathologic complete response (pCR) rate for the surgical cohort was 28%, and the pCR and near CR rates (0%-1% residual cells) were 50%. While there were significantly fewer local-regional recurrences in the preoperative group (3/29) than in the definitive CChT/PBT group (16/33) (log-rank test, p = 0.005), there were no differences in distant metastatic (DM)-free interval or overall survival (OS) between the two groups. Conclusions: This is the first report of patients treated with PBT/CChT for esophageal cancer. Our data suggest that this modality is associated with a few severe toxicities, but the pathologic response and clinical

  14. Aspects on the optimal photon beam energy for radiation therapy

    International Nuclear Information System (INIS)

    The selection of optimal photon beam energy is investigated both for realistic clinical bremsstrahlung beams and for monoenergetic photon beams. The photon energies covered in this investigation range from 60Co to bremsstrahlung and monoenergetic beams with maximum energies up to 50 MeV. One head and neck tumor and an advanced cervix tumor are investigated and the influence of beam direction is considered. It is shown that the use of optimized intensity modulated photon beams significantly reduces the need of beam energy selection. The most suitable single accelerator potential will generally be in the range 6-15 MV for both superficially located and deep-seated targets, provided intensity-modulated dose delivery is employed. It is also shown that a narrow penumbra region of a photon beam ideally should contain low-energy photons (≤4 MV), whereas the gross tumor volume, particularly when deep-seated targets are concerned, should be irradiated by high-energy photons. The regions where low photon energies are most beneficial are where organs at risk are laterally close to the target volume. The situation is completely changed when uniform or wedged beams are used. The selection of optimal beam energy then becomes a very important task in line with the experience from traditional treatment techniques. However, even with a large number of uniform beam portals, the treatment outcome is substantially lower than with a few optimized intensity-modulated beams. (orig.)

  15. Production rate calculations for a secondary beam facility

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, C.L.; Back, B.B.; Rehm, K.E.

    1995-08-01

    In order to select the most cost-effective method for the production of secondary ion beams, yield calculations for a variety of primary beams were performed ranging in mass from protons to {sup 18}O with energies of 100-200 MeV/u. For comparison, production yields for 600-1000 MeV protons were also calculated. For light ion-(A < {sup 4}He) induced reactions at energies above 50 MeV/u the LAHET code was used while the low energy calculations were performed with LPACE. Heavy-ion-induced production rates were calculated with the ISAPACE program. The results of these codes were checked against each other and wherever possible a comparison with experimental data was performed. These comparisons extended to very exotic reaction channels, such as the production of {sup 100}Sn from {sup 112}Sn and {sup 124}Xe induced fragmentation reactions. These comparisons indicate that the codes are able to predict production rates to within one order of magnitude.

  16. In-phantom spectra and dose distributions from a high-energy neutron therapy beam

    CERN Document Server

    Benck, S; Denis, J M; Meulders, J P; Nath, R; Pitcher, E J

    2002-01-01

    In radiotherapy with external beams, healthy tissues surrounding the target volumes are inevitably irradiated. In the case of neutron therapy, the estimation of dose to the organs surrounding the target volume is particularly challenging, because of the varying contributions from primary and secondary neutrons and photons of different energies. The neutron doses to tissues surrounding the target volume at the Louvain-la-Neuve (LLN) facility were investigated in this work. At LLN, primary neutrons have a broad spectrum with a mean energy of about 30 MeV. The transport of a 10x10 cm sup 2 beam through a water phantom was simulated by means of the Monte Carlo code MCNPX. Distributions of energy-differential values of neutron fluence, kerma and kerma equivalent were estimated at different locations in a water phantom. The evolution of neutron dose and dose equivalent inside the phantom was deduced. Measurements of absorbed dose and of dose equivalent were then carried out in a water phantom using an ionization ch...

  17. A white-beam fast-shutter for microbeam radiation therapy at the ESRF

    CERN Document Server

    Renier, M; Nemoz, C; Thomlinson, W

    2002-01-01

    The ID17 Medical Beamline port at the European Synchrotron Radiation Facility (ESRF) delivers white beam generated by a 1.4 T wiggler. It is devoted to medical applications of synchrotron radiation. One major program of the beamline is called Microbeam Radiation Therapy (MRT). In this radiotherapy technique, still under development, the white beam fan is divided into several microbeams before reaching the target which is a tumoral brain. The maximum skin-entrance absorbed dose can reach extremely high values (over 1000 Gy) before causing tissue necrosis, while causing tumor necrosis. One of the key parameters for the success of the MRT is the accurate control of the radiation dose delivered to the target, as well as its location with respect to the tumor, to prevent unnecessary damage to normal tissues. Therefore, the opening and closing positions of the shutter while the target is moving vertically at a constant speed reaching 150 mm/s must be carefully controlled. Shutter opening times as short as 5+-0.5 ms...

  18. The TRIUMF-ISAC facility: two decades of discovery with rare isotope beams

    Science.gov (United States)

    Ball, G. C.; Hackman, G.; Krücken, R.

    2016-09-01

    Since 1999, the TRIUMF-ISAC facility has been providing rare isotope beams for nuclear physics experiments. The three pillars of the program are nuclear structure, nuclear astrophysics, and fundamental symmetries. This article reviews highlights of each of these aspects of the ISAC science program, including tests of the collective behaviors, first explained by Bohr, Mottelson and Rainwater, at the limits of nuclear stability, and future prospects with the ARIEL facility at TRIUMF.

  19. Upgrade of the 'Genome' facility for radiobiological experiments at heavy ion beams

    International Nuclear Information System (INIS)

    We describe the Genome-M facility for automated quick irradiation of thin biological samples with accelerated heavy ions at the U400M cyclotron of the Laboratory of Nuclear Reactions, Joint Institute for Nuclear Research (JINR), as well as methods of beam quality monitoring and ionization chamber calibration in absorbed dose units, and the facility control software. During an hour, Genome-M allows the exposure of many different samples to radiation with predetermined and controlled irradiation characteristics

  20. J-PARC designated as the 'specific advanced neutron beam facility'

    International Nuclear Information System (INIS)

    Two years ago, the Japanese Government applied in 'Law for the Promotion of Public Utilization of the Specific Advanced Large Research Facilities' to J-PARC for its secure operation regardless of owner's financial conditions. Under this Law, the Comprehensive Research Organization for Science and Society (CROSS) has been awarded the 'Registered Institution for Facilities Use Promotion' to conduct users program for the public beam lines at the Japanese Spallation Neutron Source. (author)

  1. ECR ion source based low energy ion beam facility

    International Nuclear Information System (INIS)

    Over the past two decades or so, electron cyclotron resonance (ECR) ion sources have created a tremendous impact and given a major boost to technology and science in the production of high intensity multiply charged ions. A project was undertaken to develop a research facility consisting of an ECR source along with all its peripheral electronics and vacuum components placed on a 200 kV high voltage platform for obtaining multiply charged ions in a widely varying energy range from a few kilo electron volts (keV) to a few million electron volts (MeV)

  2. Multipass beam breakup in the CEBAF [Continuous Electron Beam Accelerator Facility] superconducting linac

    International Nuclear Information System (INIS)

    Multipass beam breakup can severely limit current in superconducting linear accelerators due to the inherently high Q's of transverse deflecting modes of the rf cavities. The success of higher-order-mode damping in increasing threshold currents for the 4-pass CEBAF SRF linac design is investigated with computer modeling. This simulation is shown to be in agreement with theoretical analyses which have successfully described beam breakup in the Stanford superconducting, recirculating linac. Numerical evaluation of an analytic treatment by Gluckstern of multipass beam breakup with distributed cavities is also found to be consistent with the computer model. Application of the simulation to the design array of 400 five-cell CEBAF/Cornell cavities with measured higher-order-mode damping indicates that the beam breakup threshold current is at least an order of magnitude above the CEBAF design current of 200 μA

  3. Developing an expert system to control a beam line at the Los Alamos Meson Physics Facility

    International Nuclear Information System (INIS)

    High energy particle experiments require an accelerator as a source of high energy particles. To increase the productivity of an accelerator facility, we wish to develop an expert system to control beam lines. Expert Systems are a branch of Artificial Intelligence where a computer program performs tasks requiring human expertise. Unlike most expert systems we have a physical model underlying our beam line and this model can be used with the expert system to improve performance. The development of the expert system will lead to an increased understanding of the beam line as well as the possibility of state-of-the-art expert system building

  4. Facile electron-beam lithography technique for irregular and fragile substrates

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Jiyoung; Zhou, Qin; Zettl, Alex, E-mail: azettl@berkeley.edu [Department of Physics, University of California at Berkeley, Berkeley, California 94720 (United States); Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Kavli Energy NanoSciences Institute at the University of California, Berkeley, California 94720 (United States)

    2014-10-27

    A facile technique is presented which enables high-resolution electron beam lithography on irregularly-shaped, non-planar or fragile substrates such as the edges of a silicon chip, thin and narrow suspended beams and bridges, or small cylindrical wires. The method involves a spin-free dry-transfer of pre-formed uniform-thickness polymethyl methacrylate, followed by conventional electron beam writing, metal deposition, and lift-off. High-resolution patterning is demonstrated for challenging target substrates. The technique should find broad application in micro- and nano-technology research arenas.

  5. NA61/SHINE facility at the CERN SPS: beams and detector system

    OpenAIRE

    Ereditato, Antonio; Hierholzer, Martin; Messina, Marcello; Nirkko, Martti; Pistillo, Ciro; Redij, Asmita Ajit; Rossi, Biagio

    2014-01-01

    NA61/SHINE (SPS Heavy Ion and Neutrino Experiment) is a multi-purpose experimental facility to study hadron production in hadron-proton, hadron-nucleus and nucleus-nucleus collisions at the CERN Super Proton Synchrotron. It recorded the first physics data with hadron beams in 2009 and with ion beams (secondary 7Be beams) in 2011. NA61/SHINE has greatly profited from the long development of the CERN proton and ion sources and the accelerator chain as well as the H2 beamline of the CERN North A...

  6. Optimization study for an epithermal neutron beam for boron neutron capture therapy at the University of Virginia Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Burns, T.D. Jr.

    1995-05-01

    The non-surgical brain cancer treatment modality, Boron Neutron Capture Therapy (BNCT), requires the use of an epithermal neutron beam. This purpose of this thesis was to design an epithermal neutron beam at the University of Virginia Research Reactor (UVAR) suitable for BNCT applications. A suitable epithermal neutron beam for BNCT must have minimal fast neutron and gamma radiation contamination, and yet retain an appreciable intensity. The low power of the UVAR core makes reaching a balance between beam quality and intensity a very challenging design endeavor. The MCNP monte carlo neutron transport code was used to develop an equivalent core radiation source, and to perform the subsequent neutron transport calculations necessary for beam model analysis and development. The code accuracy was validated by benchmarking output against experimental criticality measurements. An epithermal beam was designed for the UVAR, with performance characteristics comparable to beams at facilities with cores of higher power. The epithermal neutron intensity of this beam is 2.2 {times} 10{sup 8} n/cm{sup 2} {center_dot} s. The fast neutron and gamma radiation KERMA factors are 10 {times} 10{sup {minus}11}cGy{center_dot}cm{sup 2}/n{sub epi} and 20 {times} 10{sup {minus}11} cGy{center_dot}cm{sup 2}/n{sub epi}, respectively, and the current-to-flux ratio is 0.85. This thesis has shown that the UVAR has the capability to provide BNCT treatments, however the performance characteristics of the final beam of this study were limited by the low core power.

  7. LHCB: A LHCb-VELO module as beam quality monitor for proton therapy beam at the Clatterbridge Centre for Oncology

    CERN Multimedia

    Casse, G; Patel, G D; Smith, N A; Kacperek, A; Marsland, B

    2010-01-01

    The progress in detector technology, driven by the needs of particle tracking and vertexing in the present LHC and its upgrade (sLHC), has led to the design of silicon sensors with low mass, high granularity, high speed and unprecedented radiation hardness. The sensors designed for such a harsh environment can be profitably used for instrumenting the control systems of therapeutic hadron beams. The high granularity and readout clock speed are well suited for monitoring continuous beam currents. The low mass allows reduced interference with the beam whilst monitoring its profile with high precision. The high resolution and sensitivity to minimum ionising particles allows monitoring of the beam spot position by measurement of the halo in real time, without any interference with the beam spot used in therapy.

  8. High Resolution Muon Computed Tomography at Neutrino Beam Facilities

    CERN Document Server

    Suerfu, Burkhant

    2015-01-01

    X-ray computed tomography (CT) has an indispensable role in constructing 3D images of objects made from light materials. However, limited by absorption coefficients, X-rays cannot deeply penetrate materials such as copper and lead. Here we show via simulation that muon beams can provide high resolution tomographic images of dense objects and of structures within the interior of dense objects. The effects of resolution broadening from multiple scattering diminish with increasing muon momentum. As the momentum of the muon increases, the contrast of the image goes down and therefore requires higher resolution in the muon spectrometer to resolve the image. The variance of the measured muon momentum reaches a minimum and then increases with increasing muon momentum. The impact of the increase in variance is to require a higher integrated muon flux to reduce fluctuations. The flux requirements and level of contrast needed for high resolution muon computed tomography are well matched to the muons produced in the pio...

  9. Beam Based HOM Analysis of Acceleating Structures at the TESLA Test Facility LINAC

    CERN Document Server

    Wendt, M; Gössel, A

    2003-01-01

    The beam emittance in future linear accelerators for high energy physics and SASE-FEL applications depends highly on the field performance in the accelerating structures, i.e. the damping of higher order modes (HOM). Besides theoretical and laboratory analysis (network analyzer), a beam based analysis technique was established [S. Fartoukh, et.al., Proceedings of the PAC99 Conference] at the TESLA Test Facility (TTF) linac. It uses a charge modulated beam of variable modulation frequency to excite dipole modes. This causes a modulation of the transverse beam displacement, which is observed at a downstream BPM and associated with a direct analysis of the modes at the HOM couplers. Emphasis of this presentation is put on beam instrumentation and signal analysis aspects. A brief introduction of eigenmodes in resonant structures, as well as some interesting measurement results are further presented.

  10. A new ion beam facility based on a 3 MV Tandetron™ at IFIN-HH, Romania

    Energy Technology Data Exchange (ETDEWEB)

    Burducea, I.; Straticiuc, M. [Horia Hulubei National Institute of Physics and Nuclear Engineering, IFIN-HH, Măgurele 077125 (Romania); Ghiță, D.G., E-mail: dan.ghita@nipne.ro [Horia Hulubei National Institute of Physics and Nuclear Engineering, IFIN-HH, Măgurele 077125 (Romania); Moșu, D.V.; Călinescu, C.I. [Horia Hulubei National Institute of Physics and Nuclear Engineering, IFIN-HH, Măgurele 077125 (Romania); Podaru, N.C.; Mous, D.J.W. [High Voltage Engineering Europa B.V., P.O. Box 99, 3800AB Amersfoort (Netherlands); Ursu, I.; Zamfir, N.V. [Horia Hulubei National Institute of Physics and Nuclear Engineering, IFIN-HH, Măgurele 077125 (Romania)

    2015-09-15

    A 3 MV Tandetron™ accelerator system has been installed and commissioned at the “Horia Hulubei” National Institute for Physics and Nuclear Engineering – IFIN-HH, Măgurele, Romania. The main purpose of this machine is to strengthen applied nuclear physics research ongoing in our institute for more than four decades. The accelerator system was developed by High Voltage Engineering Europa B.V. (HVE) and comprises three high energy beam lines. The first beam line is dedicated to ion beam analysis (IBA) techniques: Rutherford Backscattering Spectrometry – RBS, Nuclear Reaction Analysis – NRA, Particle Induced X-ray and γ-ray Emission – PIXE and PIGE and micro-beam experiments – μ-PIXE. The second beam line is dedicated to high energy ion implantation experiments and the third beam line was designed mainly for nuclear cross-sections measurements used in nuclear astrophysics. A unique feature, the first time in operation at an accelerator facility is the Na charge exchange canal (CEC), which is used to obtain high intensity beams of He{sup −} of at least 3 μA. The results of the acceptance tests demonstrate the huge potential of this new facility in various fields, from IBA to radiation hardness studies and from medical or environmental applications to astrophysics. The main features of the accelerator are presented in this paper.

  11. A new ion beam facility based on a 3 MV Tandetron™ at IFIN-HH, Romania

    International Nuclear Information System (INIS)

    A 3 MV Tandetron™ accelerator system has been installed and commissioned at the “Horia Hulubei” National Institute for Physics and Nuclear Engineering – IFIN-HH, Măgurele, Romania. The main purpose of this machine is to strengthen applied nuclear physics research ongoing in our institute for more than four decades. The accelerator system was developed by High Voltage Engineering Europa B.V. (HVE) and comprises three high energy beam lines. The first beam line is dedicated to ion beam analysis (IBA) techniques: Rutherford Backscattering Spectrometry – RBS, Nuclear Reaction Analysis – NRA, Particle Induced X-ray and γ-ray Emission – PIXE and PIGE and micro-beam experiments – μ-PIXE. The second beam line is dedicated to high energy ion implantation experiments and the third beam line was designed mainly for nuclear cross-sections measurements used in nuclear astrophysics. A unique feature, the first time in operation at an accelerator facility is the Na charge exchange canal (CEC), which is used to obtain high intensity beams of He− of at least 3 μA. The results of the acceptance tests demonstrate the huge potential of this new facility in various fields, from IBA to radiation hardness studies and from medical or environmental applications to astrophysics. The main features of the accelerator are presented in this paper

  12. A new ion beam facility based on a 3 MV Tandetron™ at IFIN-HH, Romania

    Science.gov (United States)

    Burducea, I.; Straticiuc, M.; Ghiță, D. G.; Moșu, D. V.; Călinescu, C. I.; Podaru, N. C.; Mous, D. J. W.; Ursu, I.; Zamfir, N. V.

    2015-09-01

    A 3 MV Tandetron™ accelerator system has been installed and commissioned at the "Horia Hulubei" National Institute for Physics and Nuclear Engineering - IFIN-HH, Măgurele, Romania. The main purpose of this machine is to strengthen applied nuclear physics research ongoing in our institute for more than four decades. The accelerator system was developed by High Voltage Engineering Europa B.V. (HVE) and comprises three high energy beam lines. The first beam line is dedicated to ion beam analysis (IBA) techniques: Rutherford Backscattering Spectrometry - RBS, Nuclear Reaction Analysis - NRA, Particle Induced X-ray and γ-ray Emission - PIXE and PIGE and micro-beam experiments - μ-PIXE. The second beam line is dedicated to high energy ion implantation experiments and the third beam line was designed mainly for nuclear cross-sections measurements used in nuclear astrophysics. A unique feature, the first time in operation at an accelerator facility is the Na charge exchange canal (CEC), which is used to obtain high intensity beams of He- of at least 3 μA. The results of the acceptance tests demonstrate the huge potential of this new facility in various fields, from IBA to radiation hardness studies and from medical or environmental applications to astrophysics. The main features of the accelerator are presented in this paper.

  13. Design and characterization of the beam monitor detectors of the Italian National Center of Oncological Hadron-therapy (CNAO)

    International Nuclear Information System (INIS)

    A new hadron-therapy facility implementing an active beam scanning technique has been developed at the Italian National Center of Oncological Hadron-therapy (CNAO). This paper presents the design and the characterization of the beam monitor detectors developed for the on-line monitoring and control of the dose delivered during a treatment at CNAO. The detectors are based on five parallel-plate transmission ionization chambers with either a single large electrode or electrodes segmented in 128 strips (strip chambers) and 32×32 pixels (pixel chamber). The detectors are arranged in two independent boxes with an active area larger than 200×200 mm2 and a total water equivalent thickness along the beam path of about 0.9 mm. A custom front-end chip with 64 channels converts the integrated ionization channels without dead-time. The detectors were tested at the clinical proton beam facility of the Paul Scherrer Institut (PSI) which implements a spot scanning technique, each spot being characterized by a predefined number of protons delivered with a pencil beam in a specified point of the irradiation field. The short-term instability was measured by delivering several identical spots in a time interval of few tenths of seconds and is found to be lower than 0.3%. The non-uniformity, measured by delivering sequences of spots in different points of the detector surface, results to be lower than 1% in the single electrode chambers and lower than 1.5% in the strip and pixel chambers, reducing to less than 0.5% and 1% in the restricted 100×100 mm2 central area of the detector.

  14. The rapid cycling synchrotron of the Eurisol / Beta-Beam facility

    International Nuclear Information System (INIS)

    In order to ask for physicians requests, some neutrinos facilities are under studies to produce pure, intense, well collimated neutrinos beams with a well determined energy spectrum. One of them, the Beta-Beam project, is based on neutrinos production by radioactive ion beams decay after acceleration. The thesis is focused on one step of the complex, namely the low energy ring required for accumulation and injection of ion beams between the post-acceleration linac of the EURISOL complex (dedicated complex for radioactive ion beam production) and the CERN PS. After the description of the EURISOL complex and the Beta-Beam complex, a description of charged particles beams transport formalism is given. Then, in the second part, studies on the definition and the optimisation of the ring are given, starting by optical structure then different simulations concerning beam dynamics, i.e. multiturn injection, synchronous acceleration with beam losses localization and intensity, fast extraction, chromaticity with eddy currents correction and space charge effects. Finally, a preliminary technical design of the RCS main magnets is proposed. (author)

  15. Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions

    OpenAIRE

    Berman, Abigail T.; Sara St. James; Ramesh Rengan

    2015-01-01

    Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT), through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve the therapeutic ratio. Herein, we provide a primer on the physics of proton beam therapy for lung canc...

  16. Beamlines of the biomedical imaging and therapy facility at the Canadian light source – part 3

    International Nuclear Information System (INIS)

    The BioMedical Imaging and Therapy (BMIT) facility provides synchrotron-specific imaging and radiation therapy capabilities [1–4]. We describe here the Insertion Device (ID) beamline 05ID-2 with the beam terminated in the SOE-1 (Secondary Optical Enclosure) experimental hutch. This endstation is designed for imaging and therapy research primarily in animals ranging in size from mice to humans to horses, as well as tissue specimens including plants. Core research programs include human and animal reproduction, cancer imaging and therapy, spinal cord injury and repair, cardiovascular and lung imaging and disease, bone and cartilage growth and deterioration, mammography, developmental biology, gene expression research as well as the introduction of new imaging methods. The source for the ID beamline is a multi-pole superconducting 4.3 T wiggler [5]. The high field gives a critical energy over 20 keV. The high critical energy presents shielding challenges and great care must be taken to assess shielding requirements [6–9]. The optics in the POE-1 and POE-3 hutches [4,10] prepare a monochromatic beam that is 22 cm wide in the last experimental hutch SOE-1. The double crystal bent-Laue or Bragg monochromator, or the single-crystal K-edge subtraction (KES) monochromator provide an energy range appropriate for imaging studies in animals (20–100+ keV). SOE-1 (excluding the basement structure 4 m below the experimental floor) is 6 m wide, 5 m tall and 10 m long with a removable back wall to accommodate installation and removal of the Large Animal Positioning System (LAPS) capable of positioning and manipulating animals as large as a horse [11]. This end-station also includes a unique detector positioner with a vertical travel range of 4.9 m which is required for the KES imaging angle range of +12.3° to –7.3°. The detector positioner also includes moveable shielding integrated with the safety shutters. An update on the status of the other two end-stations at BMIT

  17. Beamlines of the biomedical imaging and therapy facility at the Canadian light source – part 3

    Energy Technology Data Exchange (ETDEWEB)

    Wysokinski, Tomasz W., E-mail: bmit@lightsource.ca [Canadian Light Source, Saskatoon, SK (Canada); Chapman, Dean [Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, SK (Canada); Adams, Gregg [Western College of Veterinary Medicine, Saskatoon, SK (Canada); Renier, Michel [European Synchrotron Radiation Facility, Grenoble (France); Suortti, Pekka [Department of Physics, University of Helsinki (Finland); Thomlinson, William [Department of Physics, University of Saskatchewan, Saskatoon, SK (Canada)

    2015-03-01

    The BioMedical Imaging and Therapy (BMIT) facility provides synchrotron-specific imaging and radiation therapy capabilities [1–4]. We describe here the Insertion Device (ID) beamline 05ID-2 with the beam terminated in the SOE-1 (Secondary Optical Enclosure) experimental hutch. This endstation is designed for imaging and therapy research primarily in animals ranging in size from mice to humans to horses, as well as tissue specimens including plants. Core research programs include human and animal reproduction, cancer imaging and therapy, spinal cord injury and repair, cardiovascular and lung imaging and disease, bone and cartilage growth and deterioration, mammography, developmental biology, gene expression research as well as the introduction of new imaging methods. The source for the ID beamline is a multi-pole superconducting 4.3 T wiggler [5]. The high field gives a critical energy over 20 keV. The high critical energy presents shielding challenges and great care must be taken to assess shielding requirements [6–9]. The optics in the POE-1 and POE-3 hutches [4,10] prepare a monochromatic beam that is 22 cm wide in the last experimental hutch SOE-1. The double crystal bent-Laue or Bragg monochromator, or the single-crystal K-edge subtraction (KES) monochromator provide an energy range appropriate for imaging studies in animals (20–100+ keV). SOE-1 (excluding the basement structure 4 m below the experimental floor) is 6 m wide, 5 m tall and 10 m long with a removable back wall to accommodate installation and removal of the Large Animal Positioning System (LAPS) capable of positioning and manipulating animals as large as a horse [11]. This end-station also includes a unique detector positioner with a vertical travel range of 4.9 m which is required for the KES imaging angle range of +12.3° to –7.3°. The detector positioner also includes moveable shielding integrated with the safety shutters. An update on the status of the other two end-stations at BMIT

  18. Beamlines of the biomedical imaging and therapy facility at the Canadian light source - part 3

    Science.gov (United States)

    Wysokinski, Tomasz W.; Chapman, Dean; Adams, Gregg; Renier, Michel; Suortti, Pekka; Thomlinson, William

    2015-03-01

    The BioMedical Imaging and Therapy (BMIT) facility provides synchrotron-specific imaging and radiation therapy capabilities [1-4]. We describe here the Insertion Device (ID) beamline 05ID-2 with the beam terminated in the SOE-1 (Secondary Optical Enclosure) experimental hutch. This endstation is designed for imaging and therapy research primarily in animals ranging in size from mice to humans to horses, as well as tissue specimens including plants. Core research programs include human and animal reproduction, cancer imaging and therapy, spinal cord injury and repair, cardiovascular and lung imaging and disease, bone and cartilage growth and deterioration, mammography, developmental biology, gene expression research as well as the introduction of new imaging methods. The source for the ID beamline is a multi-pole superconducting 4.3 T wiggler [5]. The high field gives a critical energy over 20 keV. The high critical energy presents shielding challenges and great care must be taken to assess shielding requirements [6-9]. The optics in the POE-1 and POE-3 hutches [4,10] prepare a monochromatic beam that is 22 cm wide in the last experimental hutch SOE-1. The double crystal bent-Laue or Bragg monochromator, or the single-crystal K-edge subtraction (KES) monochromator provide an energy range appropriate for imaging studies in animals (20-100+ keV). SOE-1 (excluding the basement structure 4 m below the experimental floor) is 6 m wide, 5 m tall and 10 m long with a removable back wall to accommodate installation and removal of the Large Animal Positioning System (LAPS) capable of positioning and manipulating animals as large as a horse [11]. This end-station also includes a unique detector positioner with a vertical travel range of 4.9 m which is required for the KES imaging angle range of +12.3° to -7.3°. The detector positioner also includes moveable shielding integrated with the safety shutters. An update on the status of the other two end-stations at BMIT, described

  19. Activation studies of the light ion beam target development facility

    International Nuclear Information System (INIS)

    Biological dose calculations have been performed for the target chamber of the Target Development Facility (TDF). Placement of an neutron moderator structure in the interior of the target chamber for the moderation of the high energy neutrons has been investigated as a viable option for lowering the biological dose rates of the chamber wall materials, Al6061-T6 and 2 1/4Cr-1Mo steel. Two moderator materials are considered, one made of H-451 graphite and the other of titanium hydride. In particular, a 40% porosity, 1 m thick graphite structure within the aluminum wall reduces the dose rate at the chamber wall outer surface to 13.1 mrem/h at 1 week after shutdown as compared to 1.29 rem/h without the moderator. A suitable maintenance schedule based on the 40% porosity graphite moderator design and on the allowable average dose of 1.25 rem per quarter is presented. (orig.)

  20. The design, fabrication and operation of the mechanical systems for the Neutral Beam Engineering Test Facility

    International Nuclear Information System (INIS)

    The Neutral Beam Engineering Test Facility (NBETF) at the Lawrence Berkeley Laboratory (LBL) is a National Test Facility used to develop long pulse Neutral Beam Sources. The Facility will test sources up to 120 keV, 50 A, with 30 s beam-on times with a 10% duty factor. For this application, an actively cooled beam dump is required and one has been constructed capable of dissipating a wide range of power density profiles. The flexibility of the design is achieved by utilizing a standard modular panel design which is incorporated into a moveable support structure comprised of eight separately controllable manipulator assemblies. The thermal hydraulic design of the panels permits the dissipation of 2 kW/cm2 anywhere on the panel surface. The cooling water requirements of the actively cooled dump system are provided by the closed loop Primary High Pressure Cooling Water System. To minimize the operating costs of continuously running this high power system, a variable speed hydraulic drive is used for the main pump. During beam pulses, the pump rotates at high speed, then cycles to low speed upon completion of the beam shot. A unique neutralizer design has been installed into the NBETF beamline. This is a gun-drilled moveable brazed assembly which provides continuous armoring of the beamline near the source. The unit penetrates the source mounting valve during operation and retracts to permit the valve to close as needed. The beamline also has an inertially cooled duct calorimeter assembly. This assembly is a moveable hinged matrix of copper plates that can be used as a beam stop up to pulse lengths of 50 ms. The beamline is also equipped with many beam scraper plates of differing detail design and dissipation capabilities

  1. Progress Report of Beijing Radioactive Ion-Beam Facility (BRIF) in 2012

    Institute of Scientific and Technical Information of China (English)

    YI; Hui; SUN; Yang

    2012-01-01

    <正>The year 2012 is featured with several important events for the Beijing Radioactive Ion-beam Facility (BRIF) project. With joint efforts from all sides, the team has made significant progress in the construction, the main equipment manufacturing, installation and assembly throughout the year.

  2. Progress Report of Beijing Radioactive Ion-Beam Facility (BRIF) in 2011

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The year 2011 is featured with several important events for the Beijing Radioactive Ion-beam Facility (BRIF) project. At the beginning of the year, the two divisions of the BRIF project, i.e. Engineering Division and Technology Division, have been merged into one as the BRIF Division.

  3. Facility for the testing of the TFTR prototype neutral beam injector

    International Nuclear Information System (INIS)

    The design of the prototype neutral beam injection system for TFTR is nearing completion at the Lawrence Livermore Laboratory. This paper describes some of the features of the facility at the Lawrence Berkeley Laboratory where this prototype will be assembled and tested

  4. Facility for the testing of the TFTR prototype neutral beam injector

    Energy Technology Data Exchange (ETDEWEB)

    Haughian, J.M.

    1977-07-01

    The design of the prototype neutral beam injection system for TFTR is nearing completion at the Lawrence Livermore Laboratory. This paper describes some of the features of the facility at the Lawrence Berkeley Laboratory where this prototype will be assembled and tested.

  5. Microwave frequency modulation of x-ray beam for radio therapy treatment system

    International Nuclear Information System (INIS)

    This patent describes a radio therapy treatment system for radiating a subject. It comprises means for generating an x-ray beam; and amplitude modulation means operative with the generating means for providing amplitude modulation of the x-ray beam at a predetermined microwave frequency

  6. Microwave frequency modulation of x-ray beam for radio therapy treatment system

    Energy Technology Data Exchange (ETDEWEB)

    Cyrulaik, R.A.

    1991-08-27

    This patent describes a radio therapy treatment system for radiating a subject. It comprises means for generating an x-ray beam; and amplitude modulation means operative with the generating means for providing amplitude modulation of the x-ray beam at a predetermined microwave frequency.

  7. Lessons from shielding retrofits at the LAMPF/LANSCE/PSR accelerator, beam lines and target facilities

    International Nuclear Information System (INIS)

    The experience in the past 7 years to improve the shielding and radiation control systems at the Los Alamos Meson Physics Facility (LAMPF) and the Manuel Lujan Jr. Neutron Scattering Center (LANSCE) provides important lessons for the design of radiation control systems at future, high beam power proton accelerator facilities. Major issues confronted and insight gained in developing shielding criteria and in the use of radiation interlocks are discussed. For accelerators and beam lines requiring hands-on-maintenance, our experience suggests that shielding criteria based on accident scenarios will be more demanding than criteria based on routinely encountered beam losses. Specification and analysis of the appropriate design basis accident become all important. Mitigation by active protection systems of the consequences of potential, but severe, prompt radiation accidents has been advocated as an alternate choice to shielding retrofits for risk management at both facilities. Acceptance of active protection systems has proven elusive primarily because of the difficulty in providing convincing proof that failure of active systems (to mitigate the accident) is incredible. Results from extensive shielding assessment studies are presented including data from experimental beam spill tests, comparisons with model estimates, and evidence bearing on the limitations of line-of-sight attenuation models in complex geometries. The scope and significant characteristics of major shielding retrofit projects at the LAMPF site are illustrated by the project to improve the shielding beneath a road over a multiuse, high-intensity beam line (Line D)

  8. Design, fabrication and operation of the mechanical systems for the Neutral Beam Engineering Test Facility

    International Nuclear Information System (INIS)

    The Neutral Beam Engineering Test Facility (NBETF) at Lawrence Berkeley Laboratory (LBL) is a National Test Facility used to develop long pulse Neutral Beam Sources. The Facility will test sources up to 120 keV, 50 A, with 30 s beam-on times with a 10% duty factor. For this application, an actively cooled beam dump is required and one has been constructed capable of dissipating a wide range of power density profiles. The flexibility of the design is achieved by utilizing a standard modular panel design which is incorporated into a moveable support structure comprised of eight separately controllable manipulator assemblies. A unique neutralizer design has been installed into the NBETF beamline. This is a gun-drilled moveable brazed assembly which provides continuous armoring of the beamline near the source. The unit penetrates the source mounting valve during operation and retracts to permit the valve to close as needed. The beamline is also equpped with many beam scraper plates of differing detail design and dissipation capabilities

  9. Towards Space Solar Power - Examining Atmospheric Interactions of Power Beams with the HAARP Facility

    CERN Document Server

    Leitgab, M

    2014-01-01

    In the most common space solar power (SSP) system architectures, solar energy harvested by large satellites in geostationary orbit is transmitted to Earth via microwave radiation. Currently, only limited information about the interactions of microwave beams with energy densities of several tens to hundreds of W/m$^2$ with the different layers of the atmosphere is available. Governmental bodies will likely require detailed investigations of safety and atmospheric effects of microwave power beams before issuing launch licenses for SSP satellite systems. This paper proposes to collect representative and comprehensive data of the interaction of power beams with the atmosphere by extending the infrastructure of the High Frequency Active Auroral Research Program (HAARP) facility in Alaska, USA. Estimates of the transmission infrastructure performance as well as measurement devices and scientific capabilities of possible upgrade scenarios will be discussed. The proposed upgrade of the HAARP facility is expected to d...

  10. Preliminary shielding estimates for the proposed National ISOL Radioactive Ion Beam (RIB) Facility at Oak Ridge

    International Nuclear Information System (INIS)

    ORNL built a first-generation Radioactive Ion Beam (RIB) facility for astrophysics and nuclear physics research; it was named Holifield Radioactive Ion Beam Facility (HRIBF) and is based on the Isotope Separator On Line (ISOL) technique. Planning is underway for a second- generation facility, the National ISOL RIB facility at Oak Ridge; it will build on the existing HRIBF and may utilize many existing components and shielded areas. Preliminary upgrade plan for the new facility includes: adding a superconducting booster for the tandem accelerator; replacing the 1960-vintage, 60-MeV proton, 50-microamp ORIC (Oak Ridge Isochronous Cyclotron) with a modern 200-MeV proton, 200-microamp cyclotron; and building a high-power 238U fission target to accept the 200-MeV proton beam. This report summarizes the results of a preliminary 1-D shielding analysis of the proposed upgrade, to determine the shielding requirements for a 0.25 mrem/h dose rate at the external surface of the exclusion area. Steel shielding weights ranging from 60 to 100 metric tons, were considered manageable; these could be reduced by a factor of 2 to 3 if the orientation of the proposed target station was changed

  11. Diagnostics in Indian test facility (INTF) for ITER-diagnostic neutral beam

    International Nuclear Information System (INIS)

    ITER Diagnostic Neutral Beam (DNB) will inject 5Hz modulated, 100 keV energetic neutral hydrogen atom beam of equivalent neutral beam current ∼ 20 A, having duty cycle 3S ON/20S OFF into the ITER torus to measure He ash density using CXRS diagnostics during ITER’s D–T phase. DNB is negative ion based neutral beam system and possesses many technological challenges in terms of producing high extracted and accelerated negative ion beam current (60A) with minimal divergence to ensure maximum neutral current transport over a path length of 20.7 m through different beamline components, maintaining their respective optimum functionalities. Modelling calculations have been carried out to optimise the design and dispersion of the beam line components. Besides validating these calculations, new concepts related to establishing the functionality of an 8 plasma driver based RF negative ion source, the beam line components specially residual ion dump (RID) and correspondingly the beam transport need to be tested to meet the DNB needs. This is envisaged in a test facility (INTF) to be set up in the ITER-India lab of IPR. Experimental set up of such a facility requires a judicious choice of various diagnostics to characterize the beam and functionality of individual beamline components. Appropriate diagnostics based on optical spectroscopy, electrical probe, thermal imaging, water calorimetry and thermocouples along with standard electrical voltage-current measurements will ensure safe operation of individual components and also the overall system. The conceptual designs of some of these diagnostics shall be presented. (author)

  12. The Proton Beams for the New Time-of-Flight Neutron Facility at the CERN-PS

    CERN Document Server

    Cappi, R; Métral, G

    2000-01-01

    The experimental determination of neutron cross sections in fission and capture reactions as a function of the neutron energy is of primary importance in nuclear physics. Recent developments at CERN and elsewhere have shown that many fields of research and development, such as the design of Accelerator-Driven Systems (ADS) for nuclear waste incineration, nuclear astrophysics, fundamental nuclear physics, dosimetry for radiological protection and therapy, would benefit from a better knowledge of neutron cross sections. A neutron facility at the CERN-PS has been proposed with the aim of carrying out a systematic and high resolution study of neutron cross sections through Time-Of-Flight (n-TOF) measurement. The facility requires a high intensity proton beam (about 0.7x1013 particles/bunch) distributed in a short bunch (about 25 ns total length) to produce the neutrons by means of a spallation process in a lead target. To achieve these characteristics, a number of complex beam gymnastics have to be performed. All...

  13. Monitoring the electron beam position at the TESLA test facility free electron laser

    International Nuclear Information System (INIS)

    The operation of a free electron laser working in the Self Amplified Spontaneous Emission mode (SASE FEL) requires the electron trajectory to be aligned with very high precision in overlap with the photon beam. In order to ensure this overlap, one module of the SASE FEL undulator at the TESLA Test Facility (TTF) is equipped with a new type of waveguide beam position monitor (BPM). Four waveguides are arranged symmetrically around the beam pipe, each channel couples through a small slot to the electromagnetic beam field. The induced signal depends on the beam intensity and on the transverse beam position in terms of beam-to-slot distance. With four slot--waveguide combinations a linear position sensitive signal can be achieved, which is independent of the beam intensity. The signals transduced by the slots are transferred by ridged waveguides through an impedance matching stage into a narrowband receiver tuned to 12 GHz. The present thesis describes design, tests, and implementation of this new type of BPM. (orig.)

  14. Monitoring the electron beam position at the TESLA test facility free electron laser

    Energy Technology Data Exchange (ETDEWEB)

    Kamps, T.

    2000-06-14

    The operation of a free electron laser working in the Self Amplified Spontaneous Emission mode (SASE FEL) requires the electron trajectory to be aligned with very high precision in overlap with the photon beam. In order to ensure this overlap, one module of the SASE FEL undulator at the TESLA Test Facility (TTF) is equipped with a new type of waveguide beam position monitor (BPM). Four waveguides are arranged symmetrically around the beam pipe, each channel couples through a small slot to the electromagnetic beam field. The induced signal depends on the beam intensity and on the transverse beam position in terms of beam-to-slot distance. With four slot--waveguide combinations a linear position sensitive signal can be achieved, which is independent of the beam intensity. The signals transduced by the slots are transferred by ridged waveguides through an impedance matching stage into a narrowband receiver tuned to 12 GHz. The present thesis describes design, tests, and implementation of this new type of BPM. (orig.)

  15. Phase space measurements at non-accessible point on the beam path of an accelerator facility

    International Nuclear Information System (INIS)

    The optimization of beam lines for particles extracted from accelerator facilities requires the knowledge of beam parameters. A method for the measurement of phase space and beam intensity distribution is represented. This method depends on the setting of quadrupole lenses that allows the imaging of beam profiles at arbitrary positions along the beam path on the same multi-wire proportional chamber, where the intensity distribution can be evaluated. The necessary focusing powers for a certain imaging task are calculated in a thin lens approximation. The corresponding focusing power for thick quadrupole lenses are calculated using the PC transport program. A comparison of the calculated focusing powers for thin and thick lenses reveals deviations at the highest field strengths, due to saturation effect. The position of the beam waist in normal and angular space is directly calculated and visualized. The horizontal and vertical waist positions are found to be rather independent of the beam energy. Extensive calculation was done to study the effect of a reduced aperture on the maximum beam emittances aax and aay of the extracted particles. The main result shows that the maximum emittance passing through depends on the waist distant and the diameter of the reduced aperture. (orig.)

  16. Design and Characterization of a Collimated Neutron Beam User Facility at SUNY Geneseo

    Science.gov (United States)

    Krieger, Michael; Padalino, Stephen; Russ, Megan; Polsin, Danae; Bienstock, Mollie; Ellison, Drew; Simone, Angela

    2012-10-01

    The Collimated Neutron Beam (CNB) Facility at SUNY Geneseo provides users an opportunity to perform neutron experiments that require a low neutron background. Neutrons with energies up to 10 MeV are produced by a Plutonium-Beryllium (Pu-Be) source and are collimated to form a well characterized beam. A six foot high, 18 inch thick shielding wall made of water-bricks was built to reduce neutron background in the target area. Neutron and gamma radiation were extensively mapped throughout the facility using a calibrated Bonner sphere, Geiger counter, plastic scintillator and an HPGe detector. Potential uses for the CNB include neutron activation, time-of-flight, attenuation and neutron detector calibration experiments. A detailed description and layout of the facility will be displayed on the poster. Funded in part by a grant from the DOE through the Laboratory for Laser Energetics.

  17. 21 CFR 892.5710 - Radiation therapy beam-shaping block.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Radiation therapy beam-shaping block. 892.5710 Section 892.5710 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Therapeutic Devices § 892.5710 Radiation therapy...

  18. Treatment of cancer of the pancreas by intraoperative electron beam therapy: physical and biological aspects

    Energy Technology Data Exchange (ETDEWEB)

    Bagne, F.R.; Dobelbower, R.R. Jr.; Milligan, A.J.; Bronn, D.G.

    1989-01-01

    Radiation therapy has had a significant and an expanded role in the management of cancer of the pancreas during the last decade. In particular, for locally advanced disease, radiation therapy has improved the median survival of patients to 1 year. Intraoperative electron beam therapy has been applied to unresectable and resectable pancreatic cancer in an attempt to enhance local control of disease and to improve patient survival. This paper presents a survey of the role of radiation therapy in treatment of cancer of the pancreas, provides information on the radiobiological aspects of this treatment modality and details the physical and dosimetric characteristics of intraoperative radiation therapy with electrons. Presented are the design specifics of an applicator system, central axis beam data, applicator parameters, dose distribution data, shielding, treatment planning and means of verification. Emphasis is placed on the collaboration and cooperation necessary for all members of the intraoperative radiation therapy team including surgeons, radiation therapists, medical physicists, anesthesiologists, technologists, and nurses.29 references.

  19. Imaging and characterization of primary and secondary radiation in ion beam therapy

    Science.gov (United States)

    Granja, Carlos; Martisikova, Maria; Jakubek, Jan; Opalka, Lukas; Gwosch, Klaus

    2016-07-01

    Imaging in ion beam therapy is an essential and increasingly significant tool for treatment planning and radiation and dose deposition verification. Efforts aim at providing precise radiation field characterization and online monitoring of radiation dose distribution. A review is given of the research and methodology of quantum-imaging, composition, spectral and directional characterization of the mixed-radiation fields in proton and light ion beam therapy developed by the IEAP CTU Prague and HIT Heidelberg group. Results include non-invasive imaging of dose deposition and primary beam online monitoring.

  20. Characterization of a tagged $\\gamma$-ray beam line at the DA$\\Phi$NE Beam Test Facility

    CERN Document Server

    Cattaneo, P W; Boffelli, F; Bulgarelli, A; Buonomo, B; Chen, A W; D'Ammando, F; Froysland, T; Fuschino, F; Galli, M; Gianotti, F; Giuliani, A; Longo, F; Marisaldi, M; Mazzitelli, G; Pellizzoni, A; Prest, M; Pucella, G; Quintieri, L; Rappoldi, A; Tavani, M; Trifoglio, M; Trois, A; Valente, P; Vallazza, E; Vercellone, S; Zambra, A; Barbiellini, G; Caraveo, P; Cocco, V; Costa, E; De Paris, G; Del Monte, E; Di Cocco, G; Donnarumma, I; Evangelista, Y; Feroci, M; Ferrari, A; Fiorini, M; Labanti, C; Lapshov, I; Lazzarotto, F; Lipari, P; Mastropietro, M; Mereghetti, S; Morelli, E; Moretti, E; Morselli, A; Pacciani, L; Perotti, F; Piano, G; Picozza, P; Pilia, M; Porrovecchio, G; Rapisarda, M; Rubini, A; Sabatini, S; Soffitta, P; Striani, E; Vittorini, V; Zanello, D; Colafrancesco, S; Giommi, P; Pittori, C; Santolamazza, P; Verrecchia, F; Salotti, L

    2011-01-01

    At the core of the AGILE scientific instrument, designed to operate on a satellite, there is the Gamma Ray Imaging Detector (GRID) consisting of a Silicon Tracker (ST), a Cesium Iodide Mini-Calorimeter and an Anti-Coincidence system of plastic scintillator bars. The ST needs an on-ground calibration with a $\\gamma$-ray beam to validate the simulation used to calculate the energy response function and the effective area versus the energy and the direction of the $\\gamma$ rays. A tagged $\\gamma$-ray beam line was designed at the Beam Test Facility (BTF) of the INFN Laboratori Nazionali of Frascati (LNF), based on an electron beam generating $\\gamma$ rays through Bremsstrahlung in a position-sensitive target. The $\\gamma$-ray energy is deduced by difference with the post-Bremsstrahlung electron energy \\cite{prest}-\\cite{hasan}. The electron energy is measured by a spectrometer consisting of a dipole magnet and an array of position sensitive silicon strip detectors, the Photon Tagging System (PTS). The use of the...

  1. Compendium of Neutron Beam Facilities for High Precision Nuclear Data Measurements

    International Nuclear Information System (INIS)

    The recent advances in the development of nuclear science and technology, demonstrating the globally growing economy, require highly accurate, powerful simulations and precise analysis of the experimental results. Confidence in these results is still determined by the accuracy of the atomic and nuclear input data. For studying material response, neutron beams produced from accelerators and research reactors in broad energy spectra are reliable and indispensable tools to obtain high accuracy experimental results for neutron induced reactions. The IAEA supports the accomplishment of high precision nuclear data using nuclear facilities in particular, based on particle accelerators and research reactors around the world. Such data are essential for numerous applications in various industries and research institutions, including the safety and economical operation of nuclear power plants, future fusion reactors, nuclear medicine and non-destructive testing technologies. The IAEA organized and coordinated the technical meeting Use of Neutron Beams for High Precision Nuclear Data Measurements, in Budapest, Hungary, 10–14 December 2012. The meeting was attended by participants from 25 Member States and three international organizations — the European Organization for Nuclear Research (CERN), the Joint Research Centre (JRC) and the Organisation for Economic Co-operation and Development (OECD) Nuclear Energy Agency (OECD/NEA). The objectives of the meeting were to provide a forum to exchange existing know-how and to share the practical experiences of neutron beam facilities and associated instrumentation, with regard to the measurement of high precision nuclear data using both accelerators and research reactors. Furthermore, the present status and future developments of worldwide accelerator and research reactor based neutron beam facilities were discussed. This publication is a summary of the technical meeting and additional materials supplied by the international

  2. Compendium of Neutron Beam Facilities for High Precision Nuclear Data Measurements. Annex: Individual Reports

    International Nuclear Information System (INIS)

    The recent advances in the development of nuclear science and technology, demonstrating the globally growing economy, require highly accurate, powerful simulations and precise analysis of the experimental results. Confidence in these results is still determined by the accuracy of the atomic and nuclear input data. For studying material response, neutron beams produced from accelerators and research reactors in broad energy spectra are reliable and indispensable tools to obtain high accuracy experimental results for neutron induced reactions. The IAEA supports the accomplishment of high precision nuclear data using nuclear facilities in particular, based on particle accelerators and research reactors around the world. Such data are essential for numerous applications in various industries and research institutions, including the safety and economical operation of nuclear power plants, future fusion reactors, nuclear medicine and non-destructive testing technologies. The IAEA organized and coordinated the technical meeting Use of Neutron Beams for High Precision Nuclear Data Measurements, in Budapest, Hungary, 10–14 December 2012. The meeting was attended by participants from 25 Member States and three international organizations — the European Organization for Nuclear Research (CERN), the Joint Research Centre (JRC) and the Organisation for Economic Co-operation and Development (OECD) Nuclear Energy Agency (OECD/NEA). The objectives of the meeting were to provide a forum to exchange existing know-how and to share the practical experiences of neutron beam facilities and associated instrumentation, with regard to the measurement of high precision nuclear data using both accelerators and research reactors. Furthermore, the present status and future developments of worldwide accelerator and research reactor based neutron beam facilities were discussed. This publication is a summary of the technical meeting and additional materials supplied by the international

  3. General design of the International Fusion Materials Irradiation Facility deuteron injector: Source and beam line

    International Nuclear Information System (INIS)

    In the framework of the International Fusion Materials Irradiation Facility-Engineering Validation and Engineering Design Activities (IFMIF-EVEDA) project, CEA/IRFU is in charge of the design and realization of the 140 mA cw deuteron Injector. The electron cyclotron resonance ion source operates at 2.45 GHz and a 4 electrode extraction system has been chosen. A 2 solenoid beam line, together with a high space charge compensation have been optimized for a proper beam injection in the 175 MHz radio frequency quadrupole. The injector will be tested with proton and deuteron beam production either in pulsed mode or in cw mode on the CEA-Saclay site before to be shipped to Japan. Special attention was paid to neutron emission due to (d,D) reaction. In this paper, the general IFMIF Injector design is reported, pointing out beam dynamics, radioprotection, diagnostics, and mechanical aspects.

  4. Novel imaging and quality assurance techniques for ion beam therapy a Monte Carlo study

    CERN Document Server

    Rinaldi, I; Jäkel, O; Mairani, A; Parodi, K

    2010-01-01

    Ion beams exhibit a finite and well defined range in matter together with an “inverted” depth-dose profile, the so-called Bragg peak. These favourable physical properties may enable superior tumour-dose conformality for high precision radiation therapy. On the other hand, they introduce the issue of sensitivity to range uncertainties in ion beam therapy. Although these uncertainties are typically taken into account when planning the treatment, correct delivery of the intended ion beam range has to be assured to prevent undesired underdosage of the tumour or overdosage of critical structures outside the target volume. Therefore, it is necessary to define dedicated Quality Assurance procedures to enable in-vivo range verification before or during therapeutic irradiation. For these purposes, Monte Carlo transport codes are very useful tools to support the development of novel imaging modalities for ion beam therapy. In the present work, we present calculations performed with the FLUKA Monte Carlo code and pr...

  5. Last ICRU recommendations for the prescription, recording and reporting of external beam therapy

    International Nuclear Information System (INIS)

    Due to the evolution of radio-therapy techniques and equipments, in 1993 the ICRU decided to modify the guidelines that had been published in the ICRU Report 29 (1978) in regard to photon beam therapy and to insert them in Report number 50 (1993). Changes that were introduced mainly concerned the prescription, recording and reporting of external beam therapy with photons. While awaiting for the upcoming publication of the report focusing on external beam therapy with electrons, the ICRU decided to publish a supplement to Report 50, as new insights had been gained after discussions with the Nordic Association of Clinical Physicists (NACP). This supplement includes the following: more accurate definitions of the margins allowing the planned target volume to be derived from the clinical target volume, the internal target volume, the expected volume of organs at-risk and the conformity index. All three points will be electrons as well new recommendations. (author)

  6. SU-E-T-577: Obliquity Factor and Surface Dose in Proton Beam Therapy

    International Nuclear Information System (INIS)

    Purpose: The advantage of lower skin dose in proton beam may be diminished creating radiation related sequalae usually seen with photon and electron beams. This study evaluates the surface dose as a complex function of beam parameters but more importantly the effect of beam angle. Methods: Surface dose in proton beam depends on the beam energy, source to surface distance, the air gap between snout and surface, field size, material thickness in front of surface, atomic number of the medium, beam angle and type of nozzle (ie double scattering, (DS), uniform scanning (US) or pencil beam scanning (PBS). Obliquity factor (OF) is defined as ratio of surface dose in 0° to beam angle Θ. Measurements were made in water phantom at various beam angles using very small microdiamond that has shown favorable beam characteristics for high, medium and low proton energy. Depth dose measurements were performed in the central axis of the beam in each respective gantry angle. Results: It is observed that surface dose is energy dependent but more predominantly on the SOBP. It is found that as SSD increases, surface dose decreases. In general, SSD, and air gap has limited impact in clinical proton range. High energy has higher surface dose and so the beam angle. The OF rises with beam angle. Compared to OF of 1.0 at 0° beam angle, the value is 1.5, 1.6, 1,7 for small, medium and large range respectively for 60 degree angle. Conclusion: It is advised that just like range and SOBP, surface dose should be clearly understood and a method to reduce the surface dose should be employed. Obliquity factor is a critical parameter that should be accounted in proton beam therapy and a perpendicular beam should be used to reduce surface dose

  7. Status and Planned Experiments of the Hiradmat Pulsed Beam Material Test Facility at CERN SPS

    CERN Document Server

    Charitonidis, Nikolaos; Fabich, Adrian; Meddahi, Malika; Gianfelice-Wendt, Eliana

    2015-01-01

    HiRadMat (High Irradiation to Materials) is a facility at CERN designed to provide high-intensity pulsed beams to an irradiation area where material samples as well as accelerator component assemblies (e.g. vacuum windows, shock tests on high power targets, collimators) can be tested. The beam parameters (SPS 440 GeV protons with a pulse energy of up to 3.4 MJ, or alternatively lead/argon ions at the proton equivalent energy) can be tuned to match the needs of each experiment. It is a test area designed to perform single pulse experiments to evaluate the effect of high-intensity pulsed beams on materials in a dedicated environment, excluding long-time irradiation studies. The facility is designed for a maximum number of 1016 protons per year, in order to limit the activation of the irradiated samples to acceptable levels for human intervention. This paper will demonstrate the possibilities for research using this facility and go through examples of upcoming experiments scheduled in the beam period 2015/201...

  8. Status and Planned Experiments of the Hiradmat Pulsed Beam Material Test Facility at CERN SPS

    Energy Technology Data Exchange (ETDEWEB)

    Charitonidis, Nikolaos [CERN; Efthymiopoulos, Ilias [CERN; Fabich, Adrian [CERN; Meddahi, Malika [CERN; Gianfelice-Wendt, Eliana [Fermilab

    2015-06-01

    HiRadMat (High Irradiation to Materials) is a facility at CERN designed to provide high-intensity pulsed beams to an irradiation area where material samples as well as accelerator component assemblies (e.g. vacuum windows, shock tests on high power targets, collimators) can be tested. The beam parameters (SPS 440 GeV protons with a pulse energy of up to 3.4 MJ, or alternatively lead/argon ions at the proton equivalent energy) can be tuned to match the needs of each experiment. It is a test area designed to perform single pulse experiments to evaluate the effect of high-intensity pulsed beams on materials in a dedicated environment, excluding long-time irradiation studies. The facility is designed for a maximum number of 1016 protons per year, in order to limit the activation of the irradiated samples to acceptable levels for human intervention. This paper will demonstrate the possibilities for research using this facility and go through examples of upcoming experiments scheduled in the beam period 2015/2016.

  9. An Indian test facility to characterise diagnostic neutral beam for ITER

    International Nuclear Information System (INIS)

    The diagnostic neutral beam (DNB) line shall be used to diagnose the He ash content in the D-T phase of the ITER machine using the charge exchange recombination spectroscopy (CXRS). Implementation of a successful DNB at ITER requires several challenges related to the production, neutralization and transport of the neutral beam over path lengths of 20.665 m, to be overcome. The delivery is aided if the above effects are tested prior to onsite commissioning. As DNB is a procurement package for INDIA, an ITER approved Indian test facility, INTF, is under construction at Institute for Plasma Research (IPR), India and is envisaged to be operational in 2015. The timeline for this facility is synchronized with the RADI, ELISE (IPP, Garching), SPIDER (RFX, Padova) in a manner that best utilization of configurational inputs available from them are incorporated in the design. This paper describes the facility in detail and discusses the experiments planned to optimise the beam transmission and testing of the beam line components using various diagnostics.

  10. An Indian test facility to characterise diagnostic neutral beam for ITER

    Energy Technology Data Exchange (ETDEWEB)

    Singh, M.J., E-mail: mahendrajit@iter-india.org [ITER-India, Institute for Plasma Research, A-29, Sector 25, GIDC, Gandhinagar, Gujrat 380025 (India); Bandyopadhyay, M.; Rotti, C.; Singh, N.P.; Shah, Sejal [ITER-India, Institute for Plasma Research, A-29, Sector 25, GIDC, Gandhinagar, Gujrat 380025 (India); Bansal, G.; Gahlaut, A.; Soni, J. [Institute for Plasma Research, Bhat, Gandhinagar, Gujrat 382428 (India); Lakdawala, H. [ITER-India, Institute for Plasma Research, A-29, Sector 25, GIDC, Gandhinagar, Gujrat 380025 (India); Waghela, Harshad [Shirkrishna Industries, Boisar, Mumbai (India); Ahmed, I.; Roopesh, G.; Baruah, U.K.; Chakraborty, A.K. [ITER-India, Institute for Plasma Research, A-29, Sector 25, GIDC, Gandhinagar, Gujrat 380025 (India)

    2011-10-15

    The diagnostic neutral beam (DNB) line shall be used to diagnose the He ash content in the D-T phase of the ITER machine using the charge exchange recombination spectroscopy (CXRS). Implementation of a successful DNB at ITER requires several challenges related to the production, neutralization and transport of the neutral beam over path lengths of 20.665 m, to be overcome. The delivery is aided if the above effects are tested prior to onsite commissioning. As DNB is a procurement package for INDIA, an ITER approved Indian test facility, INTF, is under construction at Institute for Plasma Research (IPR), India and is envisaged to be operational in 2015. The timeline for this facility is synchronized with the RADI, ELISE (IPP, Garching), SPIDER (RFX, Padova) in a manner that best utilization of configurational inputs available from them are incorporated in the design. This paper describes the facility in detail and discusses the experiments planned to optimise the beam transmission and testing of the beam line components using various diagnostics.

  11. Deuteron beam interaction with Li jet for a neutron source test facility

    International Nuclear Information System (INIS)

    Testing and evaluating candidate fusion reactor materials in a high-flux, high-energy neutron environment are critical to the success and economic feasibility of a fusion device. The current understanding of materials behavior in fission-like environments and existing fusion facilities is insufficient to ensure the necessary performance of future fusion reactor components. An accelerator-based deuterium-lithium system to generate the required high neutron flux for material testing is considered to be the most promising approach in the near future. In this system, a high-energy (30-40 MeV) deuteron beam impinges on a high-speed (10-20 m/s) lithium jet to produce the high-energy (>14 MeV) neutrons required to simulate a fusion environment via the Li (d,n) nuclear stripping reaction. Interaction of the high-energy deuteron beam and the subsequent response of the high-speed lithium jet are evaluated in detail. Deposition of the deuteron beam, jet-thermal hydraulic response, lithium-surface vaporization rate, and dynamic stability of the jet are modeled. It is found that lower beam kinetic energies produce higher surface temperature and consequently higher Li vaporization rates. Larger beam sizes significantly reduce both bulk and surface temperatures. Thermal expansion and dynamic velocities (normal to jet direction) due to beam energy deposition and momentum transfer are much lower than jet flow velocity and decrease substantially at lower beam current densities

  12. Exploring the energy/beam current parameter space for the isotope production facility (IPF) at LANSCE

    Energy Technology Data Exchange (ETDEWEB)

    Gulley, Mark S [Los Alamos National Laboratory; Bach, Hong [Los Alamos National Laboratory; Nortier, Francis M [Los Alamos National Laboratory; Pillai, Chandra [Los Alamos National Laboratory; Bitteker, Leo J [Los Alamos National Laboratory; John, Kevin D [Los Alamos National Laboratory; Valdez, Frank O [Los Alamos National Laboratory; Seifter, Achim [Los Alamos National Laboratory

    2010-09-07

    IPF has recently investigated isotope production with proton beams at energies other than the 100-MeV currently available to the IPF beam line. To maximize the yield of a particular isotope, it is necessary to measure the production rate and cross section versus proton beam energy. Studies were conducted at 800 MeV and 197 MeV to determine the cross section of Tb-159. Also, the ability to irradiate targets at different proton beam energies opens up the possibility of producing other radioisotopes. A proof-of-principle test was conducted to develop a 40-MeV tune in the 100-MeV beam line. Another parameter explored was the beam current, which was raised from the normal limit of 250 {mu}A up to 356 {mu}A via both power and repetition rate increase. This proof-of-principle test demonstrated the capability of the IPF beam line for high current operation with potential for higher isotope yields. For the full production mode, system upgrades will need to be in place to operate at high current and high duty factor. These activities are expected to provide the data needed for the development of a new and unique isotope production capability complementing the existing 100-MeV IPF facility.

  13. Beam test of multi-bunch energy compensation system in the accelerator test facility at KEK

    International Nuclear Information System (INIS)

    A beam test of the multi-bunch energy compensation system (ECS) was performed using the ΔF method with the 2856±4.327 HMz accelerating structures in the accelerator test facility (ATF) at KEK. The 1.54 GeV S-band linac of the ATF was designed to accelerate a multi-bunch beam the consists of 20 bunches with 2.8 ns spacing. The multi-bunch beam with 2.0 x 1010 electrons/bunch has an energy deviation of about 8.5% at the end of the linac due to transient beam loading without ECS. The ATF linac is the injector of the ATF damping ring (DR), whose energy acceptance is ±0.5%. The beam loading compensation system is necessary in the ATF linac for the successful injection of multi-bunch into DR. The rf system of the linac consists of 8 regular rf units with the SLED system and 2 ECS rf units without the SLED system. The accelerating structures of the regular units are driven at 2856 MHz and the 2 ECS structures are operated with slightly different rf frequencies of 2856±4.327 MHz. In the beam test, we have succeeded in compressing the multi-bunch energy spread within the energy acceptance of the DR using ΔF ECS. The principle of the beam loading compensation system of KEK-ATF and the experimental results are described in this paper. (author)

  14. Transcript of the workshop to discuss plans for a National High Intensity Radioactive Nuclear Beam Facility

    International Nuclear Information System (INIS)

    Following the ''First International Conference on Radioactive Nuclear Beams'' in Berkeley, a workshop was held on October 19, 1989 at the Lawrence Berkeley Laboratory to discuss plans for a National High Intensity Radioactive Nuclear Beam (RNB) Facility. The purpose of the workshop was -- after having discussed during the conference the physics question that can be addressed with RNBs -- to evaluate more concretely the possibilities for actually constructing such a facility in this country. It is becoming increasingly apparent that facility producing beams of radioactive nuclei with extreme neutron-to-proton ratios is of high scientific interest and technically feasible. It would allow the study of nuclear structure and astrophysical reactions very far from the line of stable nuclei, and could provide new possibilities of reaching the long-sought island of stability of superheavy nuclei. Such facilities are under advanced consideration in Japan and at CERN in Europe. This paper contains a slightly edited transcript of the tape recording that was made of the workshop

  15. Transcript of the workshop to discuss plans for a National High Intensity Radioactive Nuclear Beam Facility

    Energy Technology Data Exchange (ETDEWEB)

    Nitschke, J.M. (ed.)

    1989-10-19

    Following the First International Conference on Radioactive Nuclear Beams'' in Berkeley, a workshop was held on October 19, 1989 at the Lawrence Berkeley Laboratory to discuss plans for a National High Intensity Radioactive Nuclear Beam (RNB) Facility. The purpose of the workshop was -- after having discussed during the conference the physics question that can be addressed with RNBs -- to evaluate more concretely the possibilities for actually constructing such a facility in this country. It is becoming increasingly apparent that facility producing beams of radioactive nuclei with extreme neutron-to-proton ratios is of high scientific interest and technically feasible. It would allow the study of nuclear structure and astrophysical reactions very far from the line of stable nuclei, and could provide new possibilities of reaching the long-sought island of stability of superheavy nuclei. Such facilities are under advanced consideration in Japan and at CERN in Europe. This paper contains a slightly edited transcript of the tape recording that was made of the workshop.

  16. Potential clinical impact of laser-accelerated beams in cancer ion therapy

    Science.gov (United States)

    Obcemea, Ceferino

    2016-09-01

    In this article, I present three advantages of plasma-accelerated ion beams for cancer therapy. I discuss how: 1. low-emittance and well-collimated beams are advantageous in proximal normal tissue-sparing; 2. highly-peaked quasi-monoenergetic beams are ideal for fast energy selection and switching in Pencil Beam Scanning (PBS) as a treatment delivery; 3. high fluence and ultra-short pulse delivery produce collective excitations in the medium and enhance the stopping power. This in turn produces denser ionization track signatures (spurs, blobs, etc.) in target tumors, higher linear energy transfer, higher Bragg peak, and higher radiobiological effectiveness at the micro-level.

  17. Design Study of a Superconducting Gantry for Carbon Beam Therapy

    CERN Document Server

    Kim, J

    2016-01-01

    This paper describes the design study of a gantry for a carbon beam. The designed gantry is compact such that its size is comparable to the size of the proton gantry. This is possible by introducing superconducting double helical coils for dipole magnets. The gantry optics is designed in such a way that it provides rotation-invariant optics and variable beam size as well as point-to-parallel scanning of a beam. For large-aperture magnet, three-dimensional magnetic field distribution is obtained by invoking a computer code, and a number of particles are tracked by integrating equations of motion numerically together with three-dimensional interpolation. The beam-shape distortion due to the fringe field is reduced to an acceptable level by optimizing the coil windings with the help of genetic algorithm. Higher-order transfer coefficients are calculated and shown to be reduced greatly with appropriate optimization of the coil windings.

  18. Designing a range modulator wheel to spread-out the Bragg peak for a passive proton therapy facility

    Science.gov (United States)

    Jia, S. Bijan; Romano, F.; Cirrone, Giuseppe A. P.; Cuttone, G.; Hadizadeh, M. H.; Mowlavi, A. A.; Raffaele, L.

    2016-01-01

    In proton beam therapy, a Spread-Out Bragg peak (SOBP) is used to establish a uniform dose distribution in the target volume. In order to create a SOBP, several Bragg peaks of different ranges, corresponding to different entrance energies, with certain intensities (weights) should be combined each other. In a passive beam scattering system, the beam is usually extracted from a cyclotron at a constant energy throughout a treatment. Therefore, a SOBP is produced by a range modulator wheel, which is basically a rotating wheel with steps of variable thicknesses, or by using the ridge filters. In this study, we used the Geant4 toolkit to simulate a typical passive scattering beam line. In particular, the CATANA transport beam line of INFN Laboratori Nazionali del Sud (LNS) in Catania has been reproduced in this work. Some initial properties of the entrance beam have been checked by benchmarking simulations with experimental data. A class dedicated to the simulation of the wheel modulators has been implemented. It has been designed in order to be easily modified for simulating any desired modulator wheel and, hence, any suitable beam modulation. By using some auxiliary range-shifters, a set of pristine Bragg peaks was obtained from the simulations. A mathematical algorithm was developed, using the simulated pristine dose profiles as its input, to calculate the weight of each pristine peak, reproduce the SOBP, and finally generate a flat dose distribution. Therefore, once the designed modulator has been realized, it has been tested at CATANA facility, comparing the experimental data with the simulation results.

  19. NA61/SHINE facility at the CERN SPS: beams and detector system

    International Nuclear Information System (INIS)

    NA61/SHINE (SPS Heavy Ion and Neutrino Experiment) is a multi-purpose experimental facility to study hadron production in hadron-proton, hadron-nucleus and nucleus-nucleus collisions at the CERN Super Proton Synchrotron. It recorded the first physics data with hadron beams in 2009 and with ion beams (secondary 7Be beams) in 2011. NA61/SHINE has greatly profited from the long development of the CERN proton and ion sources and the accelerator chain as well as the H2 beamline of the CERN North Area. The latter has recently been modified to also serve as a fragment separator as needed to produce the Be beams for NA61/SHINE. Numerous components of the NA61/SHINE set-up were inherited from its predecessors, in particular, the last one, the NA49 experiment. Important new detectors and upgrades of the legacy equipment were introduced by the NA61/SHINE Collaboration. This paper describes the state of the NA61/SHINE facility — the beams and the detector system — before the CERN Long Shutdown I, which started in March 2013

  20. NA61/SHINE facility at the CERN SPS: beams and detector system

    CERN Document Server

    Abgrall, N; Aduszkiewicz, A; Ali, Y; Anticic, T; Antoniou, N; Baatar, B; Bay, F; Blondel, A; Blumer, J; Bogomilov, M; Bogusz, M; Bravar, A; Brzychczyk, J; Bunyatov, S A; Christakoglou, P; Czopowicz, T; Davis, N; Debieux, S; Dembinski, H; Diakonos, F; Di Luise, S; Dominik, W; Drozhzhova, T; Dumarchez, J; Dynowski, K; Engel, R; Efthymiopoulos, I; Ereditato, A; Fabich, A; Feofilov, G A; Fodor, Z; Fulop, A; Gazdzicki, M; Golubeva, M; Grebieszkow, K; Grzeszczuk, A; Guber, F; Haesler, A; Hasegawa, T; Hierholzer, M; Idczak, R; Igolkin, S; Ivashkin, A; Jokovic, D; Kadija, K; Kapoyannis, A; Kaptur, E; Kielczewska, D; Kirejczyk, M; Kisiel, J; Kiss, T; Kleinfelder, S; Kobayashi, T; Kolesnikov, V I; Kolev, D; Kondratiev, V P; Korzenev, A; Koversarski, P; Kowalski, S; Krasnoperov, A; Kurepin, A; Larsen, D; Laszlo, A; Lyubushkin, V V; Mackowiak-Pawlowska, M; Majka, Z; Maksiak, B; Malakhov, A I; Maletic, D; Manglunki, D; Manic, D; Marchionni, A; Marcinek, A; Marin, V; Marton, K; Mathes, H J; Matulewicz, T; Matveev, V; Melkumov, G L; Messina, M; Mrowczynski, St; Murphy, S; Nakadaira, T; Nirkko, M; Nishikawa, K; Palczewski, T; Palla, G; Panagiotou, A D; Paul, T; Peryt, W; Petukhov, O; Pistillo, C; Planeta, R; Pluta, J; Popov, B A; Posiadala, M; Pulawski, S; Puzovic, J; Rauch, W; Ravonel, M; Redij, A; Renfordt, R; Richter-Was, E; Robert, A; Rohrich, D; Rondio, E; Rossi, B; Roth, M; Rubbia, A; Rustamov, A; Rybczynski, M; Sadovsky, A; Sakashita, K; Savic, M; Schmidt, K; Sekiguchi, T; Seyboth, P; Sgalaberna, D; Shibata, M; Sipos, R; Skrzypczak, E; Slodkowski, M; Sosin, Z; Staszel, P; Stefanek, G; Stepaniak, J; Stroebele, H; Susa, T; Szuba, M; Tada, M; Tereshchenko, V; Tolyhi, T; Tsenov, R; Turko, L; Ulrich, R; Unger, M; Vassiliou, M; Veberic, D; Vechernin, V V; Vesztergombi, G; Vinogradov, L; Wilczek, A; Wlodarczyk, Z; Wojtaszek-Szwarz, A; Wyszynski, O; Zambelli, L; Zipper, W

    2014-01-01

    NA61/SHINE (SPS Heavy Ion and Neutrino Experiment) is a multi-purpose experimental facility to study hadron production in hadron-proton, hadron-nucleus and nucleus-nucleus collisions at the CERN Super Proton Synchrotron. It recorded the first physics data with hadron beams in 2009 and with ion beams (secondary 7Be beams) in 2011. NA61/SHINE has greatly profited from the long development of the CERN proton and ion sources and the accelerator chain as well as the H2 beamline of the CERN North Area. The latter has recently been modified to also serve as a fragment separator as needed to produce the Be beams for NA61/SHINE. Numerous components of the NA61/SHINE set-up were inherited from its predecessors, in particular, the last one, the NA49 experiment. Important new detectors and upgrades of the legacy equipment were introduced by the NA61/SHINE Collaboration. This paper describes the state of the NA61/SHINE facility - the beams and the detector system - before the CERN Long Shutdown I, which started in March ...

  1. Performance specifications for proton medical facility

    Energy Technology Data Exchange (ETDEWEB)

    Chu, W.T.; Staples, J.W.; Ludewigt, B.A.; Renner, T.R.; Singh, R.P.; Nyman, M.A.; Collier, J.M.; Daftari, I.K.; Petti, P.L.; Alonso, J.R. [Lawrence Berkeley Lab., CA (United States); Kubo, H.; Verhey, L.J. [University of California Davis Medical Center, Sacramento, CA (United States). Cancer Center]|[California Univ., San Francisco, CA (United States). School of Medicine; Castro, J.R. [Lawrence Berkeley Lab., CA (United States)]|[University of California Davis Medical Center, Sacramento, CA (United States). Cancer Center]|[California Univ., San Francisco, CA (United States). School of Medicine

    1993-03-01

    Performance specifications of technical components of a modern proton radiotherapy facility are presented. The technical items specified include: the accelerator; the beam transport system including rotating gantry; the treatment beamline systems including beam scattering, beam scanning, and dosimetric instrumentation; and an integrated treatment and accelerator control system. Also included are treatment ancillary facilities such as diagnostic tools, patient positioning and alignment devices, and treatment planning systems. The facility specified will accommodate beam scanning enabling the three-dimensional conformal therapy deliver .

  2. Performance Test of High Heat Flux Test Facility for the Calorimetry and Beam Control

    International Nuclear Information System (INIS)

    The Korea Heat Load Test facility, KoHLT-EB (Electron Beam) has been operating for the plasma facing components to develop fusion engineering in Korea. The ITER Neutral Beam Duct Liner (NBDL) was fabricated and tested to qualify the thermocouple fixation method for the temperature measurement during a direct collision of the high-power neutral beam during ITER operation. The NBDL is CuCrZr panels, which are actively water cooled using deep drilled channels. To perform the profile test, the assessment for the possibility of an electron beam Gaussian power density profile and the result of absorbed power for that profile before the test start is needed. To assess the possibility of Gaussian profile, for the qualification test of a Gaussian heat load profile, small calorimetry was manufactured to simulate a real heat profile in the neutral beam duct liner, and this calorimetry has two cooling channel with five thermocouples, which is the same as NBDL. Preliminary analyses with ANSYSCFX using a 3D model were performed with the calorimetry model. The heating area was modeled to be 60 mm x 250 mm. The simulated heat flux is 0.5 - 1.2 MW/m''2 at 0.75 kg/sec of the water flow rate. A steady heat flux test was performed to measure the surface heat flux, surface temperature profile. With a thermohydraulic analysis and heat load test, the Gaussian heat profile will be confirmed for this calorimetry and NBDL mockup. The Korean heat load test facility will be used to qualify the specifications of various plasma facing components in fusion devices. To conduct a beam profile test, an assessment of the possibility of electron beam Gaussian power density profile and the results of the absorbed power for that profile before the test starts are needed. To assess the possibility of a Gaussian profile, for the qualification test of the Gaussian heat load profile, a calorimeter mockup and large Cu module were manufactured to simulate real heat. For this high-heat flux test

  3. Laser beam smoothing and backscatter saturation processes in plasmas relevant to national ignition facility hohlraums

    International Nuclear Information System (INIS)

    We have used gas-filled targets irradiated by the Nova laser to simulate National Ignition Facility (NIF) hohlraum plasmas and to study the dependence of Stimulated Raman (SRS) and Brillouin (SBS) Scattering on beam smoothing at a range of laser intensities (3ω, 2 - 4 1015Wcm-2) and plasma conditions. We have demonstrated the effectiveness of polarization smoothing as a potential upgrade to the NIF. Experiments with higher intensities and higher densities characteristic of 350eV hohlraum designs indicate that with appropriate beam smoothing the backscatter from such hohlraums may be tolerable. (author)

  4. The CERN n_TOF Facility: Neutron Beams Performances for Cross Section Measurements

    CERN Document Server

    Chiaveri, E; Andrzejewski, J; Audouin, L; Barbagallo, M; Bécares, V; Bečvář, F; Belloni, F; Berthoumieux, E; Billowes, J; Boccone, V; Bosnar, D; Brugger, M; Calviani, M; Calviño, F; Cano-Ott, D; Carrapiço, C; Cerutti, F; Chin, M; Colonna, N; Cortés, G; Cortés-Giraldo, M A; Diakaki, M; Domingo-Pardo, C; Duran, I; Dressler, R; Dzysiuk, N; Eleftheriadis, C; Ferrari, A; Fraval, K; Ganesan, S; García, A R; Giubrone, G; Gómez-Hornillos, M B; Gonçalves, I F; González-Romero, E; Griesmayer, E; Guerrero, C; Gunsing, F; Gurusamy, P; Hernández-Prieto, A; Jenkins, D G; Jericha, E; Kadi, Y; Käppeler, F; Karadimos, D; Kivel, N; Koehler, P; Kokkoris, M; Krtička, M; Kroll, J; Lampoudis, C; Langer, C; Leal-Cidoncha, E; Lederer, C; Leeb, H; Leong, L S; Losito, R; Mallick, A; Manousos, A; Marganiec, J; Martínez, T; Massimi, C; Mastinu, P F; Mastromarco, M; Meaze, M; Mendoza, E; Mengoni, A; Milazzo, P M; Mingrone, F; Mirea, M; Mondalaers, W; Paradela, C; Pavlik, A; Perkowski, J; Plompen, A; Praena, J; Quesada, J M; Rauscher, T; Reifarth, R; Riego, A; Robles, M S; Roman, F; Rubbia, C; Sabaté-Gilarte, M; Sarmento, R; Saxena, A; Schillebeeckx, P; Schmidt, S; Schumann, D; Tagliente, G; Tain, J L; Tarrío, D; Tassan-Got, L; Tsinganis, A; Valenta, S; Vannini, G; Variale, V; Vaz, P; Ventura, A; Versaci, R; Vermeulen, M J; Vlachoudis, V; Vlastou, R; Wallner, A; Ware, T; Weigand, M; Weiss, C; Wright, T; Žugec, P

    2014-01-01

    This paper presents the characteristics of the existing CERN n\\_TOF neutron beam facility (n\\_TOF-EAR1 with a flight path of 185 meters) and the future one (n\\_TOF EAR-2 with a flight path of 19 meters), which will operate in parallel from Summer 2014. The new neutron beam will provide a 25 times higher neutron flux delivered in 10 times shorter neutron pulses, thus offering more powerful capabilities for measuring small mass, low cross section and/or high activity samples.

  5. Laser beam smoothing and backscatter saturation processes in plasmas relevant to national ignition facility hohlraums

    International Nuclear Information System (INIS)

    We have used gas-filled targets irradiated by the Nova laser to simulate National Ignition Facility (NIF) hohlraum plasmas and to study the dependence of Stimulated Raman (SRS) and Brillouin (SBS) Scattering on beam smoothing at a range of laser intensities (3ω, 2-41015Wcm-2) and plasma conditions. We have demonstrated the effectiveness of polarization smoothing as a potential upgrade to the NIF. Experiments with higher intensities and higher densities characteristic of 350eV hohlraum designs indicate that with appropriate beam smoothing the backscatter from such hohlraums may be tolerable. (author)

  6. Design Optimisation of a High Intensity Beam Facility and Feasibility Experiment of a Solid Fragmented Target

    CERN Document Server

    Charitonidis, Nikolaos; Rivkin, Leonid

    2014-06-13

    The present PhD thesis describes the design, execution and results of the HRMT-10 experiment performed at the HiRadMat facility of the CERN/SPS complex. The first part of the thesis covers the design optimization studies of the HiRadMat facility, focusing in particular on the radiation protection issues. A detailed Monte-Carlo model of the facility has been developed and validated through comparison with measurements. A very satisfactory agreement between the simulation and the experimental data is observed. In the second part of this thesis, a novel feasibility experiment of a fragmented solid target for a future Neutrino Factory or a Super Beam facility, able to support high beam powers ( 1 MW) is presented in detail. A solid granular target has been proposed as an interesting alternative to an open Hg jet target, presently considered as the baseline for such facilities, but posing considerable technical challenges. The HRMT-10 experiment seeks to address the lack of experimental data of the feasibility of...

  7. Future carbon beams at SPIRAL1 facility: Which method is the most efficient?

    International Nuclear Information System (INIS)

    Compared to in-flight facilities, Isotope Separator On-Line ones can in principle produce significantly higher radioactive ion beam intensities. On the other hand, they have to cope with delays for the release and ionization which make the production of short-lived isotopes ion beams of reactive and refractory elements particularly difficult. Many efforts are focused on extending the capabilities of ISOL facilities to those challenging beams. In this context, the development of carbon beams is triggering interest [H. Frånberg, M. Ammann, H. W. Gäggeler, and U. Köster, Rev. Sci. Instrum. 77, 03A708 (2006); M. Kronberger, A. Gottberg, T. M. Mendonca, J. P. Ramos, C. Seiffert, P. Suominen, and T. Stora, in Proceedings of the EMIS 2012 [Nucl. Instrum. Methods Phys. Res. B Production of molecular sideband radioisotope beams at CERN-ISOLDE using a Helicon-type plasma ion source (to be published)]: despite its refractory nature, radioactive carbon beams can be produced from molecules (CO or CO2), which can subsequently be broken up and multi-ionized to the required charge state in charge breeders or ECR sources. This contribution will present results of experiments conducted at LPSC with the Phoenix charge breeder and at GANIL with the Nanogan ECR ion source for the ionization of carbon beams in the frame of the ENSAR and EMILIE projects. Carbon is to date the lightest condensable element charge bred with an ECR ion source. Charge breeding efficiencies will be compared with those obtained using Nanogan ECRIS and charge breeding times will be presented as well

  8. 4He2+ and H2+ ion beam separation on ''Sokol'' IBA facility

    International Nuclear Information System (INIS)

    Two separation methods of 4He2+ and H2+ ion beams have been tested on ''Sokol'' IBA facility of NSC KIPT: use of existing beam-bending magnet and electrostatic analyzer, dissociation of H2+ ions when the beam passes through the carbon film. It is shown that these methods allow to decrease essentially the H2+ ion content in the 4He2+ beam.

  9. Development of compact ECR ion source for carbon therapy facility

    International Nuclear Information System (INIS)

    A 10 GHz compact Electron Cyclotron Resonance (ECR) ion source with all permanent magnets has been developed. Peaks of the mirror magnetic field along the beam axis are 0.59 T at the extraction side and 0.87 T at the gas injection side, respectively, while the minimum B strength is 0.25 T. The source has a diameter of 320 mm and a length of 295 mm. The result of beam tests shows that a C4+ intensity of 500 μA was obtained under an extraction voltage of 30 kV. This paper describes the design detail and the experimental results for the new source. (author)

  10. T2-weighted endorectal magnetic resonance imaging of prostate cancer after external beam radiation therapy

    Directory of Open Access Journals (Sweden)

    Antonio C. Westphalen

    2009-04-01

    Full Text Available PURPOSE: To retrospectively determine the accuracy of T2-weighted endorectal MR imaging in the detection of prostate cancer after external beam radiation therapy and to investigate the relationship between imaging accuracy and time since therapy. MATERIAL AND METHODS: Institutional review board approval was obtained and the study was HIPPA compliant. We identified 59 patients who underwent 1.5 Tesla endorectal MR imaging of the prostate between 1999 and 2006 after definitive external beam radiation therapy for biopsy-proven prostate cancer. Two readers recorded the presence or absence of tumor on T2-weighted images. Logistic regression and Fisher’s exact tests for 2x2 tables were used to determine the accuracy of imaging and investigate if accuracy differed between those imaged within 3 years of therapy (n = 25 and those imaged more than 3 years after therapy (n = 34. Transrectal biopsy was used as the standard of reference for the presence or absence of recurrent cancer. RESULTS: Thirty-four of 59 patients (58% had recurrent prostate cancer detected on biopsy. The overall accuracy of T2-weighted MR imaging in the detection cancer after external beam radiation therapy was 63% (37/59 for reader 1 and 71% for reader 2 (42/59. For both readers, logistic regression showed no difference in accuracy between those imaged within 3 years of therapy and those imaged more than 3 years after therapy (p = 0.86 for reader 1 and 0.44 for reader 2. CONCLUSION: T2-weighted endorectal MR imaging has low accuracy in the detection of prostate cancer after external beam radiation therapy, irrespective of the time since therapy.

  11. Status of ECR ion sources for the Facility for Rare Isotope Beams (FRIB) (invited)

    Energy Technology Data Exchange (ETDEWEB)

    Machicoane, Guillaume, E-mail: machicoane@frib.msu.edu; Morgan, Glenn; Pozdeyev, Eduard; Rao, Xing; Ren, Haitao [Facility for Rare Isotope Beams, Michigan State University, East Lansing, Michigan 48824 (United States); Felice, Helene; Hafalia, Ray; Pan, Heng; Prestemon, Soren [Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Fogleman, Jesse; Tobos, Larry [National Superconducting Cyclotron Laboratory, Michigan State University, 640 South Shaw Lane, East Lansing, Michigan 48824 (United States)

    2016-02-15

    Ahead of the commissioning schedule, installation of the first Electron Cyclotron Resonance (ECR) ion source in the front end area of the Facility for Rare Isotope Beam (FRIB) is planned for the end of 2015. Operating at 14 GHz, this first ECR will be used for the commissioning and initial operation of the facility. In parallel, a superconducting magnet structure compatible with operation at 28 GHz for a new ECR ion source is in development at Lawrence Berkeley National Laboratory. The paper reviews the overall work in progress and development done with ECR ion sources for FRIB.

  12. Status of ECR ion sources for the Facility for Rare Isotope Beams (FRIB) (invited).

    Science.gov (United States)

    Machicoane, Guillaume; Felice, Helene; Fogleman, Jesse; Hafalia, Ray; Morgan, Glenn; Pan, Heng; Prestemon, Soren; Pozdeyev, Eduard; Rao, Xing; Ren, Haitao; Tobos, Larry

    2016-02-01

    Ahead of the commissioning schedule, installation of the first Electron Cyclotron Resonance (ECR) ion source in the front end area of the Facility for Rare Isotope Beam (FRIB) is planned for the end of 2015. Operating at 14 GHz, this first ECR will be used for the commissioning and initial operation of the facility. In parallel, a superconducting magnet structure compatible with operation at 28 GHz for a new ECR ion source is in development at Lawrence Berkeley National Laboratory. The paper reviews the overall work in progress and development done with ECR ion sources for FRIB. PMID:26931961

  13. Economic and education impact of building the Continuous Electron Beam Accelerator Facility

    International Nuclear Information System (INIS)

    The Continuous Electron Beam Accelerator Facility (CEBAF) was built in Newport News, Virginia, between 1987 and 1995 and is a new basic research laboratory christened the Thomas Jefferson National Accelerator Facility (Jefferson Lab). Jefferson Lab's science and technology mission has major economic and educational benefits: basic research discoveries, improvement and application of key technologies associated with the accelerator and the experiments, extensive subcontracting with industry, and diverse employment and educational opportunities. The $600 million invested by federal, state, local and international partners to build Jefferson Lab has had substantial economic and educational benefits locally, as well as significant benefits distributed among industries and universities throughout the United States

  14. Thermal shock tests with beryllium coupons in the electron beam facility JUDITH

    Energy Technology Data Exchange (ETDEWEB)

    Roedig, M.; Duwe, R.; Schuster, J.L.A. [Forschungszentrum Juelich GmbH (Germany)] [and others

    1995-09-01

    Several grades of American and Russian beryllium have been tested in high heat flux tests by means of an electron beam facility. For safety reasons, major modifications of the facility had to be fulfilled in advance to the tests. The influence of energy densities has been investigated in the range between 1 and 7 MJ/m{sup 2}. In addition the influence of an increasing number of shots at constant energy density has been studied. For all samples, surface profiles have been measured before and after the experiments. Additional information has been gained from scanning electron microscopy, and from metallography.

  15. Status of the 7 MeV/u, 217 MHz Injector Linac for the Heidelberg Cancer Therapy Facility

    CERN Document Server

    Schlitt, B; Hutter, G; Klos, F; Lu, Y; Minaev, S A; Mühle, C; Ratzinger, U; Schlitt, B; Tiede, R; Vinzenz, W; Will, C; Zurkan, O

    2004-01-01

    A clinical synchrotron facility for cancer therapy using energetic proton and ion beams (C, He and O) is under construction and will be installed at the Radiologische Universitätsklinik in Heidelberg, Germany, starting in 2005. The status of the ECR ion source systems, the beam line components of the low energy beam transport lines, the 400 keV/u RFQ and the 20 MV IH-cavity as well as the linac rf system will be reported. Two prototype magnets of the linac quadrupole magnets have been built at GSI and have been tested successfully. A test bench for the 1.4 MW, 217 MHz cavity amplifier built by industry has been installed at GSI including a 120 kW driver amplifier which will be used also for high power tests of the RFQ. A test bench for the RFQ using proton beams is presently being set up at the IAP. RF tuning of the 1:2 scaled IH-DTL model as well as Microwave Studio simulations of the model and the power cavity have been also performed at the IAP [1].

  16. Neutron H*(10) inside a proton therapy facility: comparison between Monte Carlo simulations and WENDI-2 measurements

    International Nuclear Information System (INIS)

    Inside an IBA proton therapy centre, secondary neutrons are produced due to nuclear interactions of the proton beam with matter mainly inside the cyclotron, the beam line, the treatment nozzle and the patient. Accurate measurements of the neutron ambient dose equivalent H*(10) in such a facility require the use of a detector that has a good sensitivity for neutrons ranging from thermal energies up to 230 MeV, such as for instance the WENDI-2 detector. WENDI-2 measurements have been performed at the Westdeutsches Protonentherapiezentrum Essen, at several positions around the cyclotron room and around a gantry treatment room operated in two different beam delivery modes: Pencil Beam Scanning and Double Scattering. These measurements are compared with Monte Carlo simulation results for the neutron H*(10) obtained with MCNPX 2.5.0 and GEANT4 9.6. In proton therapy, proton beams with energies up to typically 230 MeV are used to treat cancerous tumours very efficiently while sparing surrounding healthy tissues as much as possible. Due to nuclear interactions of the proton beams with matter, mainly inside the cyclotron, the beam line, the treatment nozzle and the patient, secondary neutrons with energies up to 230 MeV are unfortunately produced, as well as photons up to ∼10 MeV. Behind the thick concrete shielding walls which are necessary to attenuate the stray radiation fields, the total ambient dose equivalent H*(10) is very large due to the neutron component. In shielding studies for proton therapy facilities, the neutron H*(10) component is often evaluated using the Monte Carlo codes MCNPX(5), FLUKA(6) or PHITS(7). Recent benchmark simulations performed with GEANT4 have shown that this code would also be a suitable tool for the shielding studies of proton therapy centres. The experimental validation of such shielding studies requires the use of a detector with a good sensitivity for neutrons ranging from thermal energies up to 230 MeV, such as for example the

  17. Optimal beam arrangement for stereotactic body radiation therapy delivery in lung tumors

    International Nuclear Information System (INIS)

    Purpose. To compare the different beam arrangement and delivery techniques for stereotactic body radiation therapy (SBRT) of lung lesions using the criteria of Radiation Therapy Oncology Group (RTOG) 0236 protocol. Material and methods. Thirty-seven medically inoperable lung cancers were evaluated with various planning techniques including multiple coplanar multiple static beams, multiple non-coplanar static beams and arc delivery. Twelve plans were evaluated for each case, including five plans using coplanar fixed beams, six plans using non-coplanar fixed beams and one plan using arc therapy. These plans were compared using the target prescription isodose coverage, high and low dose volumes, and critical organ dose-volume limits. Results. The prescription isodose coverage, high dose evaluation criteria and dose to critical organs were similar among treatment delivery techniques. However, there were differences in low dose criteria, especially in the ratio of the volume of 50% isodose of the prescription dose to the volume of planning treatment volume (R50%). The R50% in plans using non-coplanar static beams was lower than other plans in 30 of 37 cases (81%). Conclusion. Based on the dosimetric criteria outlined in RTOG 0236, the treatment technique using non-coplanar static beams showed the most preferable results for SBRT of lung lesions

  18. ISABELLE: a 400 x 400 GeV proton--proton colliding beam facility

    International Nuclear Information System (INIS)

    A conceptual design report is presented for the construction of an Intersecting Storage Accelerator, ISABELLE, to be located at Brookhaven National Laboratory. At this major research facility beams of protons with energies up to 400 GeV will be collided in six experimental areas. At each area particle physicists will install detector apparatus to study the interaction and reaction products for such very high energy collisions. The proposal results from several years of study and development work on such a facility. Topics discussed include: (1) introduction and summary of the proposal; (2) physics at ISABELLE (including physics objectives and typical experiments and detectors); description of ISABELLE (overview; magnetic ring structure and lattice characteristics; performance; beam transfer, stacking, and acceleration; magnet system; refrigeration system; vacuum system; power supplies, instrumentation, and control system; physical plant and experimental halls; and operation and safety); and (3) cost estimate and schedule

  19. ISABELLE: a 400 x 400 GeV proton--proton colliding beam facility

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-01-01

    A conceptual design report is presented for the construction of an Intersecting Storage Accelerator, ISABELLE, to be located at Brookhaven National Laboratory. At this major research facility beams of protons with energies up to 400 GeV will be collided in six experimental areas. At each area particle physicists will install detector apparatus to study the interaction and reaction products for such very high energy collisions. The proposal results from several years of study and development work on such a facility. Topics discussed include: (1) introduction and summary of the proposal; (2) physics at ISABELLE (including physics objectives and typical experiments and detectors); description of ISABELLE (overview; magnetic ring structure and lattice characteristics; performance; beam transfer, stacking, and acceleration; magnet system; refrigeration system; vacuum system; power supplies, instrumentation, and control system; physical plant and experimental halls; and operation and safety); and (3) cost estimate and schedule.

  20. Dosimetric properties of the fast neutron therapy beams at TAMVEC

    International Nuclear Information System (INIS)

    In October 1972, M.D. Anderson Hospital and Tumor Institute of the University of Texas System Cancer Center initiated a clinical trial of fast neutron radiotherapy using the cyclotron at Texas A and M University. Initially, the study used neutrons produced by bombarding beryllium with 16 MeV deuterons, but since March, 1973, neutrons from 50 MeV deuterons have been used. The dosimetric properties of the 30 MeV beams have also been measured for comparison with the neutron beams from D-T generators. The three beams are compared in terms of dose rate, skin sparing, depth dose and field flatness. Isodose curves for treatment planning were generated using the decrement line method and compared to curves measured by a computer controlled isodose plotter. This system was also used to measure the isodose curves for wedge fields. Dosimetry checks on various patients were made using silicon diodes as in vivo fast neutron dosimeters

  1. A MATLAB-based interface for the beam-transport system of an AMS facility

    Energy Technology Data Exchange (ETDEWEB)

    Gómez-Guzmán, J.M., E-mail: jm_gomez@us.es [Centro Nacional de Aceleradores (CNA), University of Seville (Spain); Dpto. de Física Atómica, Molecular y Nuclear, University of Seville (Spain); Gómez-Morilla, I. [Technische Universität Dresden, Fakultät Maschinenwesen, Professur für Magnetofluiddynamik (Germany); Enamorado-Báez, S.M.; Moreno-Suárez, A.I.; Pinto-Gómez, A.R. [Centro Nacional de Aceleradores (CNA), University of Seville (Spain)

    2013-12-01

    In this paper we present a MATLAB code built to model the transport of a charged particle beam through the Accelerator Mass Spectrometry (AMS) facility located at the Centro Nacional de Aceleradores (CNA, Seville, Spain). We determine the beam transport through the optical system using the transfer matrix formalism in two different approaches (ray tracing and the beam-envelope approach) and describe it in terms of cross section size and emittance. The beam size results given by MATLAB are compared with the measured beam size in three of the four image points that the system has, obtaining a good agreement between them. This suggests that the first-order transfer matrix formalism is enough to simulate the optical behavior of the system. The present version of this interface enables the user to control, interact with and display a beam transport system. Parameters involved in the optics such as voltages applied to the lenses, terminal voltage and charge state of the selected ion can be modified using this interface, which gives great generality, as the optics behavior of the AMS system can be simulated for any ion species prior to operation.

  2. Analysis of different design options for the beam target of the energy amplifier demonstration facility

    International Nuclear Information System (INIS)

    A thermal fluid dynamic analysis of different design options of a high intensity proton beam target has been performed for the 80 MW Demonstration Facility of the Energy Amplifier proposed by C. Rubbia (EADF), presently under development in Italy by Ansaldo, CRS4, ENEA and INFN. The present machine is driven by a 600 MeV proton accelerator at a current varying from about 2 to 6 mA during the fuel cycle. Two options have been considered: (i) a 'windowless' design, where the free surface of the spallation material (liquid Pb-Bi eutectic) is the interface with the void of the beam transport line, and (ii) a 'window' design, where a physical separation is made by means of a 9Cr 1Mo V Nb martensitic steel hemispherical window. Both designs have advantages and drawbacks. The beam window is a delicate element whose lifetime is at present moment difficult to assess, since it is affected by the combined action of liquid metal corrosion, radiation damage (induced by protons and high energy neutrons interactions) and thermal fatigue (induced by stress cycling due to beam trips and beam interruptions). The windowless option is less sensible to radiation damage, but its design is more complex for the presence of a free surface flow and of Pb-Bi vapours in the beam pipe. (author)

  3. A MATLAB-based interface for the beam-transport system of an AMS facility

    International Nuclear Information System (INIS)

    In this paper we present a MATLAB code built to model the transport of a charged particle beam through the Accelerator Mass Spectrometry (AMS) facility located at the Centro Nacional de Aceleradores (CNA, Seville, Spain). We determine the beam transport through the optical system using the transfer matrix formalism in two different approaches (ray tracing and the beam-envelope approach) and describe it in terms of cross section size and emittance. The beam size results given by MATLAB are compared with the measured beam size in three of the four image points that the system has, obtaining a good agreement between them. This suggests that the first-order transfer matrix formalism is enough to simulate the optical behavior of the system. The present version of this interface enables the user to control, interact with and display a beam transport system. Parameters involved in the optics such as voltages applied to the lenses, terminal voltage and charge state of the selected ion can be modified using this interface, which gives great generality, as the optics behavior of the AMS system can be simulated for any ion species prior to operation

  4. Neutron skyshine from end stations of the Continuous Electron Beam Accelerator Facility

    International Nuclear Information System (INIS)

    The MORSE CG code from Oak Ridge National Laboratory was applied to the estimation of the neutron skyshine from three end stations of the Continuous Electron Beam Accelerator Facility (CEBAF), Newport News, VA. Calculations with other methods and an experiment had been directed at assessing the annual neutron dose equivalent at the site boundary. A comparison of results obtained with different methods is given, and the effect of different temperatures and humidities will be discussed

  5. Radiological and the other safety aspects in the operation of electron beam facility

    International Nuclear Information System (INIS)

    The radiological safety aspects of the operation of an electron beam facility in general and the 3 MeV ALURTRON electron beam facility of the Malaysian Institute of Nuclear Technology Research (MINT) in particular were reviewed and evaluated. Evaluation was made based on existing records as well as actual monitoring around facility. Area monitoring results using TLDs are within permissible levels. The maximum reading of 7.29 mSv measured in year 2000 is very low as compared to the annual dose limit of 50 mSv/year. In general, the shielding for the installation is adequate and no significant radiation leakage were detected based on radiation survey results. However, measured radiation levels with a maximum of 1.9 mSv/h at the sampling ports easily exceed the limit of 25μSv/h. The facility is equipped with safety features, such as interlocked system, adequate shielding, engineered safety design of irradiation and accelerator rooms, and accessories such as conveyor system and product handling system. Warning lights and signals are adequately installed around the facility. Other identified hazards that may affect the operator, workers, and personnel were also evaluated based on previous records of monitoring. The ozone concentration levels with a maximum reading of 0.05 ppm measured in the environment of the facility are within the threshold limit value of 0.1 ppm. The measured noise levels at all locations around facility are generally below the maximum permissible level of 80dB. The ALURTRON has achieved a minimum safety requirement to warrant its full operation without relying on administrative controls and procedures to ensure safety in operation. (Auth.)

  6. Upgrade of the facility EXOTIC for the in-flight production of light Radioactive Ion Beams

    International Nuclear Information System (INIS)

    Highlights: • Production of in-flight Radioactive Ion Beams via two-body reactions. • Development of a cryogenic gas target. • Event-by-event tracking via Parallel Plate Avalanche Counters (PPACs). -- Abstract: The facility EXOTIC for the in-flight production of light weakly-bound Radioactive Ion Beams (RIBs) has been operating at INFN-LNL since 2004. RIBs are produced via two-body reactions induced by high intensity heavy-ion beams impinging on light gas targets and selected by means of a 30°-dipole bending magnet and a 1-m long Wien filter. The facility has been recently upgraded (i) by developing a cryogenic gas target, (ii) by replacing the power supplies of the middle lenses of the two quadrupole triplets, (iii) by installing two y-steerers and (iv) by placing two Parallel Plate Avalanche Counters upstream the secondary target to provide an event-by-event reconstruction of the position hit on the target. So far, RIBs of 7Be, 8B and 17F in the energy range 3–5 MeV/u have been produced with intensities about 3 × 105, 1.6 × 103 and 105 pps, respectively. Possible light RIBs (up to Z = 10) deliverable by the facility EXOTIC are also reviewed

  7. Physics at a future Neutrino Factory and super-beam facility

    CERN Document Server

    Bandyopadhyay, A; Gandhi, R; Goswami, S; Roberts, B L; Bouchez, J; Antoniadis, I; Ellis, J; Giudice, G F; Schwetz, T; Umansankar, S; Karagiorgi, G; Aguilar-Arevalo, A; Conrad, J M; Shaevitz, M H; Pascoli, Silvia; Geer, S; Rolinec, M; Blondel, A; Campanelli, M; Kopp, J; Lindner, M; Peltoniemi, J; Dornan, P J; Long, K; Matsushita, T; Rogers, C; Uchida, Y; Dracos, M; Whisnant, K; Casper, D; Chen, Mu-Chun; Popov, B; Aysto, J; Marfatia, D; Okada, Y; Sugiyama, H; Jungmann, K; Lesgourgues, J; Murayama, France H; Zisman, M; Tortola, M A; Friedland, A; Antusch, S; Biggio, C; Donini, A; Fernandez-Martinez, E; Gavela, B; Maltoni, M; Lopez-Pavon, J; Rigolin, S; Mondal, N; Palladino, V; Filthaut, F; Albright, C; de Gouvea, A; Kuno, Y; Nagashima, Y; Mezzetoo, M; Lola, S; Langacker, P; Baldini, A; Nunokawa, H; Meloni, D; Diaz, M; King, S F; Zuber, K; Akeroyd, A G; Grossman, Y; Farzan, Y; Tobe, K; Aoki, Mayumi; Kitazawa, N; Yasuda, O; Petcov, S; Romanino, A; Chimenti, P; Vacchi, A; Smirnov, A Yu; Couce, Italy E; Gomez-Cadenas, J J; Hernandez, P; Sorel, M; Valle, J W F; Harrison, P F; Lundardini, C; Nelson, J K; Barger, V; Everett, L; Huber, P; Winter, W; Fetscher, W; van der Schaaf, A

    2009-01-01

    The conclusions of the Physics Working Group of the international scoping study of a future Neutrino Factory and super-beam facility (the ISS) are presented. The ISS was carried by the international community between NuFact05, (the 7th International Workshop on Neutrino Factories and Superbeams, Laboratori Nazionali di Frascati, Rome, June 21-26, 2005) and NuFact06 (Ivine, California, 24{30 August 2006). The physics case for an extensive experimental programme to understand the properties of the neutrino is presented and the role of high-precision measurements of neutrino oscillations within this programme is discussed in detail. The performance of second generation super-beam experiments, beta-beam facilities, and the Neutrino Factory are evaluated and a quantitative comparison of the discovery potential of the three classes of facility is presented. High-precision studies of the properties of the muon are complementary to the study of neutrino oscillations. The Neutrino Factory has the potential to provide ...

  8. AGS SUPER NEUTRINO BEAM FACILITY ACCELERATOR AND TARGET SYSTEM DESIGN (NEUTRINO WORKING GROUP REPORT-II).

    Energy Technology Data Exchange (ETDEWEB)

    DIWAN,M.; MARCIANO,W.; WENG,W.; RAPARIA,D.

    2003-04-21

    This document describes the design of the accelerator and target systems for the AGS Super Neutrino Beam Facility. Under the direction of the Associate Laboratory Director Tom Kirk, BNL has established a Neutrino Working Group to explore the scientific case and facility requirements for a very long baseline neutrino experiment. Results of a study of the physics merit and detector performance was published in BNL-69395 in October 2002, where it was shown that a wide-band neutrino beam generated by a 1 MW proton beam from the AGS, coupled with a half megaton water Cerenkov detector located deep underground in the former Homestake mine in South Dakota would be able to measure the complete set of neutrino oscillation parameters: (1) precise determination of the oscillation parameters {Delta}m{sub 32}{sup 2} and sin{sup 2} 2{theta}{sub 32}; (2) detection of the oscillation of {nu}{sub {mu}}-{nu}{sub e} and measurement of sin{sup 2} 2{theta}{sub 13}; (3) measurement of {Delta}m{sub 21}{sup 2} sin 2{theta}{sub 12} in a {nu}{sub {mu}} {yields} {nu}{sub e} appearance mode, independent of the value of {theta}{sub 13}; (4) verification of matter enhancement and the sign of {Delta}m{sub 32}{sup 2}; and (5) determination of the CP-violation parameter {delta}{sub CP} in the neutrino sector. This report details the performance requirements and conceptual design of the accelerator and the target systems for the production of a neutrino beam by a 1.0 MW proton beam from the AGS. The major components of this facility include a new 1.2 GeV superconducting linac, ramping the AGS at 2.5 Hz, and the new target station for 1.0 MW beam. It also calls for moderate increase, about 30%, of the AGS intensity per pulse. Special care is taken to account for all sources of proton beam loss plus shielding and collimation of stray beam halo particles to ensure equipment reliability and personal safety. A preliminary cost estimate and schedule for the accelerator upgrade and target system are also

  9. Cavity beam position monitor system for the Accelerator Test Facility 2

    CERN Document Server

    Kim, Y I; Aryshev, A; Boogert, S T; Boorman, G; Frisch, J; Heo, A; Honda, Y; Hwang, W H; Huang, J Y; Kim, E -S; Kim, S H; Lyapin, A; Naito, T; May, J; McCormick, D; Mellor, R E; Molloy, S; Nelson, J; Park, S J; Park, Y J; Ross, M; Shin, S; Swinson, C; Smith, T; Terunuma, N; Tauchi, T; Urakawa, J; White, G R

    2013-01-01

    The Accelerator Test Facility 2 (ATF2) is a scaled demonstrator system for final focus beam lines of linear high energy colliders. This paper describes the high resolution cavity beam position monitor (BPM) system, which is a part of the ATF2 diagnostics. Two types of cavity BPMs are used, C-band operating at 6.423 GHz, and S-band at 2.888 GHz with an increased beam aperture. The cavities, electronics, and digital processing are described. The resolution of the C-band system with attenuators was determined to be approximately 250 nm and 1 m for the S-band system. Without attenuation the best recorded C-band cavity resolution was 27 nm.

  10. Design study of an intense laser and electron beam interaction experimental facility

    International Nuclear Information System (INIS)

    Background: It is challenging to realize very small beta function and dispersion free colliding region in a limited space. Purpose: Tiny electron beam sizes are required to achieve high flux in ultra-short and intense laser-electron compton scattering facilities. Methods: Beam characteristics for different matching conditions are studied with the presence of various alignment and field errors. Results: Beta function of laser-electron beam spot can be up to 0.01 meter and the dispersion function is zero at the same time. The optimization calculations of some main factor's including magnetic field error and mechanical installation error are also performed. Conclusions: A mini-beta scheme with the achromatic treatment can be found to meet the experimental requirements. (authors)

  11. 2 MeV, 60 kW dual-beam type electron accelerator irradiation facility

    International Nuclear Information System (INIS)

    The specification of new irradiation facility which has been constructed from 1978 through 1981 as the replacement of 1st Accelerator of JAERI, TRCRE are described. The accelerator is the Cockcroft-Walton type and both vertical and horizontal accelerating tubes are arranged on a single high voltage generator. Transferring of the high voltage to the horizontal accelerating tube is performed with the high voltage changing system in the pressure vessel. The output ratings of the accelerator are 2 MV of acceleration voltage and 30 mA of beam current. By providing the dual beam system, two irradiation rooms, one for vertical and the other for horizontal beam, are independently operationable. Persons can enter the horizontal irradiation room for experimental setting even when the vertical irradiation room is in operation. The specification of the buildings, the exhaust air treatment system, the irradiation conveyor and the safety observation system are also described. (author)

  12. The Acceleration and Storage of Radioactive Ions for a Beta-Beam Facility

    CERN Document Server

    Lindroos, M; Napoly, O; Payet, J; Benedikt, Michael; Butler, P; Garoby, R; Hancock, S; Köster, U; Lindroos, M; Magistris, M; Nilsson, T; Wenander, F; Blondel, A; Gilardoni, S S; Boine-Frankenheim, O; Franzke, B; Höllinger, R; Steck, Markus; Spiller, P J; Weick, H; Burguet, J; Gómez-Cadenas, J J; Hernández, P; Laune, B; Müller, A; Sortais, P; Villari, A C C; Volpe, C; Facco, A; Mezzetto, Mauro; Palladino, V; Pisent, A; Zucchelli, P; Delbar, T; Ryckewaert, G; Chartier, M; Prior, C; Reistad, D; Baartman, R A; Jansson, A

    2004-01-01

    The term beta-beam has been coined for the production of a pure beam of electron neutrinos or their antiparticles through the decay of radioactive ions circulating in a storage ring. This concept requires radioactive ions to be accelerated to as high Lorentz  as 150. The neutrino source itself consists of a storage ring for this energy range, with long straight sections in line with the experiment(s). Such a decay ring does not exist at CERN today, nor does a high-intensity proton source for the production of the radioactive ions. Nevertheless, the existing CERN accelerator infrastructure could be used as this would still represent an important saving for a beta-beam facility.

  13. Materials science and biophysics applications at the ISOLDE radioactive ion beam facility

    CERN Document Server

    Wahl, U

    2011-01-01

    The ISOLDE isotope separator facility at CERN provides a variety of radioactive ion beams, currently more than 800 different isotopes from ~65 chemical elements. The radioisotopes are produced on-line by nuclear reactions from a 1.4 GeV proton beam with various types of targets, outdiffusion of the reaction products and, if possible, chemically selective ionisation, followed by 60 kV acceleration and mass separation. While ISOLDE is mainly used for nuclear and atomic physics studies, applications in materials science and biophysics account for a significant part (currently ~15%) of the delivered beam time, requested by 18 different experiments. The ISOLDE materials science and biophysics community currently consists of ~80 scientists from more than 40 participating institutes and 21 countries. In the field of materials science, investigations focus on the study of semiconductors and oxides, with the recent additions of nanoparticles and metals, while the biophysics studies address the toxicity of metal ions i...

  14. Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions

    Energy Technology Data Exchange (ETDEWEB)

    Berman, Abigail T., E-mail: abigail.berman@uphs.upenn.edu [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104 (United States); James, Sara St.; Rengan, Ramesh [Department of Radiation Oncology, University of Washington Medical Center, Seattle, WA 98195 (United States)

    2015-07-02

    Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT), through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve the therapeutic ratio. Herein, we provide a primer on the physics of proton beam therapy for lung cancer, present the existing data in early-stage and locally-advanced non-small cell lung cancer (NSCLC), as well as in special situations such as re-irradiation and post-operative radiation therapy. We then present the technical challenges, such as anatomic changes and motion management, and future directions for PBT in lung cancer, including pencil beam scanning.

  15. Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions

    International Nuclear Information System (INIS)

    Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT), through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve the therapeutic ratio. Herein, we provide a primer on the physics of proton beam therapy for lung cancer, present the existing data in early-stage and locally-advanced non-small cell lung cancer (NSCLC), as well as in special situations such as re-irradiation and post-operative radiation therapy. We then present the technical challenges, such as anatomic changes and motion management, and future directions for PBT in lung cancer, including pencil beam scanning

  16. Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions

    Directory of Open Access Journals (Sweden)

    Abigail T. Berman

    2015-07-01

    Full Text Available Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT, through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve the therapeutic ratio. Herein, we provide a primer on the physics of proton beam therapy for lung cancer, present the existing data in early-stage and locally-advanced non-small cell lung cancer (NSCLC, as well as in special situations such as re-irradiation and post-operative radiation therapy. We then present the technical challenges, such as anatomic changes and motion management, and future directions for PBT in lung cancer, including pencil beam scanning.

  17. A micro-pattern gaseous detector for beam monitoring in ion-therapy

    Science.gov (United States)

    Terakawa, A.; Ishii, K.; Matsuyama, S.; Kikuchi, Y.; Togashi, T.; Arikawa, J.; Yamashita, W.; Takahashi, Y.; Fujishiro, F.; Yamazaki, H.; Sakemi, Y.

    2015-12-01

    A micro-pattern gaseous detector based on gas electron multiplier technology (GEM detector) was developed as a new transmission beam monitor for charged-particle therapy to obtain real-time information about the parameters of a therapeutic beam. Feasibility tests for the GEM detector were performed using an 80-MeV proton beam to evaluate the lateral intensity distributions of a pencil beam and the dose delivered to a target. The beam intensity distributions measured with the GEM detector were in good agreement with those measured with an imaging plate while the charge output from the GEM detector was in proportion to that of a reference dose monitor of an ionization chamber design. These experimental results showed that the GEM detector can be used not only as a beam monitor for the position and two-dimensional intensity distribution but also as a dose monitor. Thus, it is possible to simultaneously measure these beam parameters for beam control in charged-particle therapy using a single GEM-based transmission monitor.

  18. Facility to disinfect medical wastes by 10 MeV electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Kerluke, D.R. [Ion Beam Applications s.a., Louvain-la-Neuve (Belgium)

    1998-12-31

    As regulations related to the disposal of infectious hospital and other medical waste are become increasingly stringent, hospitals and governments worldwide are looking to develop more effective and economical means to disinfect such waste materials prior to them being ultimately landfilled, incinerated or recycled. With the advent of reliable high-energy, high-power industrial electron accelerators, the prospect now exists to centralize collection of much of the infectious medical waste for major metropolitan areas at a single facility, and render it harmless using irradiation. Using much of the same or similar methodologies already developed for single-use medical device sterilization and for bioburden reduction in other goods, high energy electron beam treatment offers unique process advantages which become increasingly attractive with the economies of scale available at higher power. This paper will explore some of the key issues related to the safe disposition of infectious hospital and other medical waste, related irradiation research projects, and the design and economic factors related to an electron beam facility dedicated to this application. This will be presented in the context of the Rhodotron family of electron beam accelerators manufactured by Ion Beam Applications s.a. (author)

  19. SU-E-J-99: Reconstruction of Cone Beam CT Image Using Volumetric Modulated Arc Therapy Exit Beams

    International Nuclear Information System (INIS)

    Purpose: To test the possibility of obtaining an image of the treated volume during volumetric modulated arc therapy (VMAT) with exit beams. Method: Using a Varian Clinac 21EX and MVCT detector the following three sets of detector projection data were obtained for cone beam CT reconstruction with and without a Catphan 504 phantom. 1) 72 projection images from 20 × 16 cm2 open beam with 3 MUs, 2) 72 projection images from 20 × 16 cm2 MLC closed beam with 14 MUs. 3) 137 projection images from a test RapicArc QA plan. All projection images were obtained in ‘integrated image’ mode. We used OSCaR code to reconstruct the cone beam CT images. No attempts were made to reduce scatter or artifacts. Results: With projection set 1) we obtained a good quality MV CBCT image by optimizing the reconstruction parameters. Using projection set 2) we were not able to obtain a CBCT image of the phantom, which was determined to be due to the variation of interleaf leakage with gantry angle. From projection set 3), we were able to obtain a weak but meaningful signal in the image, especially in the target area where open beam signals were dominant. This finding suggests that one might be able to acquire CBCT images with rough body shape and some details inside the irradiated target area. Conclusion: Obtaining patient images using the VMAT exit beam is challenging but possible. We were able to determine sources of image degradation such as gantry angle dependent interleaf leakage and beams with a large scatter component. We are actively working on improving image quality

  20. Head and Neck Cancer Treatment with Particle Beam Therapy

    Directory of Open Access Journals (Sweden)

    Mehrzad Zargarzadeh

    2013-01-01

    Full Text Available In this century, cancer incidence has become one of the most significant problems concerning human. Conventional radiotherapy damage healthy tissue and in some cases may cause new primary cancers. This problem can be partially solved by hadron therapy which would be more effective and less harmful compared to other forms of radiotherapies used to treat some cancers. Although carbon ion and proton therapy both are effective treatments, they have serious differences which are mentioned in this paper and compared between the two methods. Furthermore, various treatments have been performed on head and neck cancer with hadrons so far will be discussed.

  1. The H line: a brand new beam line for fundamental physics at the J-PARC muon facility

    International Nuclear Information System (INIS)

    The muon facility, J-PARC (Muon Science Establishment; MUSE), has been operated since first beam in 2008. Starting with a 200 kW proton beam, the beam intensity has reached 3×106/ muons/s, the most intense pulsed muon beam in the world. A 2 cm thick graphite target permits the extraction of four secondary muon beams. A brand new beam line, the H line, is planned to be constructed. The new beam line is designed to have a large acceptance, will provide the ability to tune the momentum, and use a kicker magnet and/or Wien filter. This beam line will provide an intense beam for experiments that require high statistics and must occupy the experimental areas for a relatively long period.

  2. Experience with high-energy electron beam therapy at the University of Chicago

    Energy Technology Data Exchange (ETDEWEB)

    Griem, M L; Kuchnir, F T; Lanzl, L H; Skaggs, L S; Sutton, H G; Tokars, R

    1979-01-01

    Current utilization of the linear accelerator as well as 5-year cumulative experience in radiotherapy is presented. Cutaneous lymphomas and mammary gland carcinomas were the prime experience region; however, cancers at other locations were treated with mixed-beam therapy; employing fast neutrons and photon beams. The technique appears promising for abdominal tumors and deep-seated malignancies. Carcinoma of the pancreas responds favorably to this technique. (PCS)

  3. Project of an advanced ISOL facility for exotic beams at LNL

    Energy Technology Data Exchange (ETDEWEB)

    Tecchio, L.B. E-mail: tecchio@lnl.infn.it; Andrighetto, A.; Cherubini, R.; Colautti, P.; Comunian, M.; Corradi, L.; Dainelli, A.; De Angelis, G.; De Poli, M.; Facco, A.; Fioretto, E.; Fortuna, G.; Jiyu, G.; Ming, R.; Montagnoli, G.; Moschini, G.; Pisent, A.; Poggi, M.; Porcellato, A.M.; Zafiropoulos, D.; Bak, P.; Kot, N.; Logatchev, P.; Shyankov, S.; Brandolini, F.; Signorini, C.; Clauser, T.; Lamanna, G.; Stagno, V.; Variale, V

    2002-04-22

    In the framework of the European program to define a second generation Radioactive Ion Beam facility, LNL are proposing the construction in the next five-seven years of a specialized national facility for RIB originated by fission fragments produced by secondary neutrons. It consists on a two-accelerator ISOL-type facility to provide intense neutron-rich radioactive ion beams of highest quality, in the range of masses between 80 and 160. The conceptual design is based on a high intensity 50 MeV (100 kW) proton linac as driver and on the availability of the heavy-ion accelerator ALPI as post accelerator. The estimated neutron yield is 2x10{sup 14} n/s at 0 deg., high enough to satisfy the demand for an advanced RIB facility. An intense R and D program on different items is actually in progress in collaboration with other Laboratories and University groups and is moving in a European context.

  4. Structural integrity assessment based on the HFR Petten neutron beam facilities

    CERN Document Server

    Ohms, C; Idsert, P V D

    2002-01-01

    Neutrons are becoming recognized as a valuable tool for structural-integrity assessment of industrial components and advanced materials development. Microstructure, texture and residual stress analyses are commonly performed by neutron diffraction and a joint CEN/ISO Pre-Standard for residual stress analysis is under development. Furthermore neutrons provide for defects analyses, i.e. precipitations, voids, pores and cracks, through small-angle neutron scattering (SANS) or radiography. At the High Flux Reactor, 12 beam tubes have been installed for the extraction of thermal neutrons for such applications. Two of them are equipped with neutron diffractometers for residual stress and structure determination and have been extensively used in the past. Several other facilities are currently being reactivated and upgraded. These include the SANS and radiography facilities as well as a powder diffractometer. This paper summarizes the main characteristics and current status of these facilities as well as recently in...

  5. Liquid deuterium neutron attenuator for broad-band photon beam facility

    International Nuclear Information System (INIS)

    The photo-production facility at Fermilab uses a two section liquid deuterium attenuator, 103 feet in length, to reduce the neutron flux and produce a pure high energy photon beam. The facility is located in the Proton East experimental hall, and includes nine 10 foot long sweeping magnets. A unique refrigeration system supplies mechanically refrigerated helium gas trace cooling to condense deuterium directly in a flask. The control system permits remote operation of the cryogenic system and also acts as an interface to the Proton Area operations computer. The computer can be used to monitor the operating parameters and for partial control of the system. The facility is presently in use as part of the Proton Area experimental program. (auth)

  6. Commissioning and First Results of the ITER-Relevant Negative Ion Beam Test Facility ELISE

    International Nuclear Information System (INIS)

    Full text: For heating and current drive the ITER NBI system requires a negative hydrogen ion source capable of delivering above 40 A of D- ions for up to one hour pulses with an accelerated current density of 200 A/m2 . In order to limit the power loads and ion losses in the accelerator, the source must be operated at a pressure of 0.3 Pa at maximum and the amount of co-extracted electrons must not exceed the amount of extracted negative ions. As presently these parameters have not yet been achieved simultaneously, also due to a lack of adequate test facilities, the European ITER domestic agency F4E has defined an R&D roadmap for the construction of the neutral beam heating systems. An important step herein is the new test facility ELISE (Extraction from a Large Ion Source Experiment) for a large-scale extraction from a half-size ITER RF source which was constructed in the last 2 years at IPP Garching. The early experience of the operation of such a large RF driven source (1 x 1 m2 with an extraction area of 0.1 m2) will give an important input for the design of the Neutral Beam Test Facility PRIMA in Padova and the ITER NBI systems and for their commissioning and operating phases. PRIMA consists of the 1 MeV full power test facility MITICA, operational 2017, and the 100 kV ion source test facility SPIDER, operational 2015. The aim of the design of the ELISE source and extraction system was to be as close as possible to the ITER design; it has however some modifications allowing a better diagnostic access as well as more flexibility for exploring open questions. The extraction system is designed for the acceleration of 20 A of negative hydrogen ions of up to 60 kV. Plasma operation of up to one hour is foreseen; but due to the limits of the IPP HV system, pulsed extraction only is possible. ELISE went into operation in spring 2012 with first plasma and beam pulses. The paper discusses critical issues of the manufacturing and describes the commissioning phases of

  7. Beam-Beam Effects

    OpenAIRE

    Herr, W; Pieloni, T.

    2016-01-01

    One of the most severe limitations in high-intensity particle colliders is the beam-beam interaction, i.e. the perturbation of the beams as they cross the opposing beams. This introduction to beam-beam effects concentrates on a description of the phenomena that are present in modern colliding beam facilities.

  8. Beam-Beam Effects

    CERN Document Server

    Herr, W

    2014-01-01

    One of the most severe limitations in high-intensity particle colliders is the beam-beam interaction, i.e. the perturbation of the beams as they cross the opposing beams. This introduction to beam-beam effects concentrates on a description of the phenomena that are present in modern colliding beam facilities.

  9. Multiscale approach predictions for biological outcomes in ion-beam cancer therapy

    OpenAIRE

    Alexey Verkhovtsev; Eugene Surdutovich; Solov’yov, Andrey V.

    2016-01-01

    Ion-beam therapy provides advances in cancer treatment, offering the possibility of excellent dose localization and thus maximising cell-killing within the tumour. The full potential of such therapy can only be realised if the fundamental mechanisms leading to lethal cell damage under ion irradiation are well understood. The key question is whether it is possible to quantitatively predict macroscopic biological effects caused by ion radiation on the basis of physical and chemical effects rela...

  10. Calculation of the dose to lymphocytes in external beam radiation therapy

    International Nuclear Information System (INIS)

    Lymphopenia is known to occur in patients undergoing external beam radiation therapy when the radiation fields encompass major blood vessels and lymphatic tissue. The dose received by the lymphocytes has up to now not been determined. We present here a general formalism for the calculation of the lymphocyte dose for a patient undergoing fractionated radiation therapy at any irradiation site. The calculation procedure is demonstrated for a typical case of pelvic irradiation

  11. Calculation of the dose to lymphocytes in external beam radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Ekstrand, K.E.; Dixon, R.L.; Plunkett, S.; Raben, M.

    1981-02-01

    Lymphopenia is known to occur in patients undergoing external beam radiation therapy when the radiation fields encompass major blood vessels and lymphatic tissue. The dose received by the lymphocytes has up to now not been determined. We present here a general formalism for the calculation of the lymphocyte dose for a patient undergoing fractionated radiation therapy at any irradiation site. The calculation procedure is demonstrated for a typical case of pelvic irradiation.

  12. Establishment of the Neutron Beam Research Facility at the OPAL Reactor

    International Nuclear Information System (INIS)

    Full text: Australia's first research reactor, HIFAR, reached criticality in January 1958. At that time Australia's main agenda was establishment of a nuclear power program. HIFAR operated for nearly 50 years, providing a firm foundation for the establishment of Australia's second generation research Reactor OPAL, which reached criticality in August 006. In HIFAR's early years a neutron beam facility was established for materials characterization, partly in aid of the nuclear energy agenda and partly in response to interest from Australia's scientific community. By the time Australia's nuclear energy program ceased (in the 1970s), radioisotope production and research had also been established at Lucas Heights. Also, by this time the neutron beam facility for scientific research had evolved into a major utilization programme, warranting establishment of an independent body to facilitate scientific access (the Australian Institute for Nuclear Science and Engineering). In HIFAR's lifetime, ANSTO established a radiopharmaceuticals service for the Australian medical community and NDT silicon production was also established and grew to maturity. So when time came to determine the strategy for nuclear research in Australia into the 21st century, it was clear that the replacement for HIFAR should be multipurpose, with major emphases on scientific applications of neutron beams and medical isotope production. With this strategy in mind, ANSTO set about to design and build OPAL with a world-class neutron beam facility, capable of supporting a large and diverse scientific research community. The establishment of the neutron beam facility became the mission of the Bragg Institute management team. This journey began in 1997 with establishment of a working budget, and reached its first major objective when OPAL reached 20 MW thermal power nearly one decade later (in 2006). The first neutron beam instruments began operation soon after (in 2007), and quickly proved themselves to be

  13. Development of an external beam nuclear microprobe on the Aglae facility of the Louvre museum

    Energy Technology Data Exchange (ETDEWEB)

    Calligaro, T.; Dran, J.-C. E-mail: dran@culture.fr; Ioannidou, E.; Moignard, B.; Pichon, L.; Salomon, J

    2000-03-01

    The external beam line of our facility has been recently equipped with the focusing system previously mounted on a classical nuclear microprobe. When using a 0.1 {mu}m thick Si{sub 3}N{sub 4} foil for the exit window and flowing helium on the sample under analysis, a beam spot as small as 10 {mu}m is attainable at a distance of 3 mm from the window. Elemental micromapping is performed by mechanical scanning. An electronic device has been designed which allows XY scanning by moving the sample under the beam by steps down to 0.1 {mu}m. Beam monitoring is carried out by means of the weak X-ray signal emitted by the exit foil and detected by a specially designed Si(Li) detector cooled by Peltier effect. The characteristics of external beams of protons and alpha particles are evaluated by means of resonance scanning and elemental mapping of a grid. An example of application is presented, dealing with elemental micro-mapping of inclusions in gemstones.

  14. Development of an external beam nuclear microprobe on the Aglae facility of the Louvre museum

    Science.gov (United States)

    Calligaro, T.; Dran, J.-C.; Ioannidou, E.; Moignard, B.; Pichon, L.; Salomon, J.

    2000-03-01

    The external beam line of our facility has been recently equipped with the focusing system previously mounted on a classical nuclear microprobe. When using a 0.1 μm thick Si 3N 4 foil for the exit window and flowing helium on the sample under analysis, a beam spot as small as 10 μm is attainable at a distance of 3 mm from the window. Elemental micromapping is performed by mechanical scanning. An electronic device has been designed which allows XY scanning by moving the sample under the beam by steps down to 0.1 μm. Beam monitoring is carried out by means of the weak X-ray signal emitted by the exit foil and detected by a specially designed Si(Li) detector cooled by Peltier effect. The characteristics of external beams of protons and alpha particles are evaluated by means of resonance scanning and elemental mapping of a grid. An example of application is presented, dealing with elemental micro-mapping of inclusions in gemstones.

  15. Is proton beam therapy the future of radiotherapy? Part I: Clinical aspects; La protontherapie: avenir de la radiotherapie? Premiere partie: aspects cliniques

    Energy Technology Data Exchange (ETDEWEB)

    Bouyon-Monteau, A.; Habrand, J.L.; Datchary, J.; Alapetite, C.; Bolle, S.; Dendale, R.; Feuvret, L.; Helfre, S.; Calugaru, V. [Centre de protontherapie d' Orsay, institut Curie, campus universitaire, 91 - Orsay (France); Bouyon-Monteau, A.; Alapetite, C.; Bolle, S.; Dendale, R.; Helfre, S.; Calugaru, V.; Cosset, J.M.; Bey, P. [Departement d' oncologie-radiotherapie, institut Curie, 75 - Paris (France); Habrand, J.L.; Datchary, J. [Departement d' oncologie-radiotherapie, institut de cancerologie Gustave-Roussy, 94 - Villejuif (France); Feuvret, L. [Departement d' oncologie-radiotherapie, hopital Pitie-Salpetriere, 75 - Paris (France)

    2010-12-15

    Proton beam therapy uses positively charged particles, protons, whose physical properties improve dose-distribution (Bragg peak characterized by a sharp distal and lateral penumbra) compared with conventional photon-based radiation therapy (X-ray). These ballistic advantages apply to the treatment of deep-sited tumours located close to critical structures and requiring high-dose levels. [60-250 MeV] proton-beam therapy is now widely accepted as the 'gold standard' in specific indications in adults - ocular melanoma, chordoma and chondrosarcoma of the base of skull - and is regarded as a highly promising treatment modality in the treatment of paediatric malignancies (brain tumours, sarcomas..). This includes the relative sparing of surrounding normal organs from low and mid-doses that can cause deleterious side-effects such as radiation-induced secondary malignancies. Other clinical studies are currently testing proton beam in dose-escalation evaluations, in prostate, lung, hepatocellular cancers, etc. Clinical validation of these new indications appears necessary. To date, over 60, 000 patients worldwide have received part or all of their radiation therapy program by proton beams, in approximately 30 treatment facilities. (authors)

  16. SPIRAL2 at GANIL: next generation of ISOL facility for intense secondary radioactive ion beams

    International Nuclear Information System (INIS)

    During the last two decades, secondary Radioactive Ion Beams (RIB) has allowed the investigation of a new territory of nuclei with extreme N/Z called *terra incognita*. The quest for Rare Isotope Beams (RIB), which are orders of magnitude more intense than those currently available, is the main motivation behind the design and construction of the next generation of RIB facilities. As selected by the ESFRI committee, the next generation of ISOL facility in Europe is represented by the SPIRAL2 project to be built at GANIL (Caen, France). SPIRAL 2 is based on a high power, CW, superconducting LINAC,delivering 5 mA of deuteron beams at 40 MeV (200 kW) directed on a C converter+Uranium target and producing more 1013 fissions/s. The expected radioactive beams intensities in the mass range from A=60 to A=140, will surpass by two order of magnitude any existing facilities in the world. These unstable atoms will be available at energies between few keV/n to 15 MeV/n. The same driver will accelerate high intensity (100*A to 1 mA), heavier ions up to Ar at 14 MeV/n. Under the 7FP program of European Union called *Preparatory phase*, the SPIRAL2 project has been granted a budget of about 4MEUR to build up an international consortium around this new venture. The status of the construction of SPIRAL2 accelerator and associated physics instruments in collaboration with EU and International partners are presented.

  17. Instrumentation and beam dynamics study of advanced electron-photon facility in Indiana University

    Science.gov (United States)

    Luo, Tianhuan

    The Advanced eLectron-PHoton fAcility (ALPHA) is a compact electron accelerator under construction and being commissioned at the Indiana University Center for Exploration of Energy and Matter (CEEM). In this thesis, we have studied the refurbished Cooler Injector Synchrotron (CIS) RF cavity using both the transmission line model and SUPERFISH simulation. Both low power and high power RF measurements have been carried out to characterize the cavity. Considering the performance limit of ferrite, we have designed a new ferrite loaded, co-axial quarter wave like cavity with similar structure but a more suitable ferrite material. We have also designed a traveling wave stripline kicker for fast extraction by POISSON and Microwave Studio. The strips' geometry is trimmed to maximize the uniformity of the kicking field and match the impedance of the power cables. The time response simulation shows the kicker is fast enough for machine operation. The pulsed power supply requirement has also been speci ed. For the beam diagnosis in the longitudinal direction, we use a wideband Wall Gap Monitor (WGM) served in CIS. With proper shielding and amplification to get good WGM signal, we have characterized the injected and extracted beam signal in single pass commissioning, and also verified the debunching effect of the ALPHA storage ring. A modulation-demodulation signal processing method is developed to measure the current and longitudinal profile of injected beam. By scanning the dipole strength in the injection line, we have reconstructed the tomography of the longitudinal phase space of the LINAC beam. In the accumulation mode, ALPHA will be operated under a low energy and high current condition, where intra beam scattering (IBS) becomes a dominant effect on the beam emittance. A self consistent simulation, including IBS effect, gas scattering and linear coupling, has been carried out to calculate the emittance of the stored beam.

  18. Instrumentation and Beam Dynamics Study of Advanced Electron-Photon Facility in Indiana University

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Tianhuan [Indiana Univ., Bloomington, IN (United States)

    2011-08-01

    The Advanced eLectron-PHoton fAcility (ALPHA) is a compact electron accelerator under construction and being commissioned at the Indiana University Center for Exploration of Energy and Matter (CEEM). In this thesis, we have studied the refurbished Cooler Injector Synchrotron (CIS) RF cavity using both the transmission line model and SUPERFISH simulation. Both low power and high power RF measurements have been carried out to characterize the cavity. Considering the performance limit of ferrite, we have designed a new ferrite loaded, co-axial quarter wave like cavity with similar structure but a more suitable ferrite material. We have also designed a traveling wave stripline kicker for fast extraction by POISSON and Microwave Studio. The strips geometry is trimmed to maximize the uniformity of the kicking field and match the impedance of the power cables. The time response simulation shows the kicker is fast enough for machine operation. The pulsed power supply requirement has also been specified. For the beam diagnosis in the longitudinal direction, we use a wideband Wall Gap Monitor (WGM) served in CIS. With proper shielding and amplification to get good WGM signal, we have characterized the injected and extracted beam signal in single pass commissioning, and also verified the debunching effect of the ALPHA storage ring. A modulation-demodulation signal processing method is developed to measure the current and longitudinal profile of injected beam. By scanning the dipole strength in the injection line, we have reconstructed the tomography of the longitudinal phase space of the LINAC beam. In the accumulation mode, ALPHA will be operated under a low energy and high current condition, where intra beam scattering (IBS) becomes a dominant effect on the beam emittance. A self consistent simulation, including IBS effect, gas scattering and linear coupling, has been carried out to calculate the emittance of the stored beam.

  19. Improved Beam Angle Arrangement in Intensity Modulated Proton Therapy Treatment Planning for Localized Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Cao, Wenhua; Lim, Gino J. [Department of Industrial Engineering, University of Houston, Houston, TX 77204 (United States); Li, Yupeng [Applied Research, Varian Medical Systems, Palo Alto, CA 94304 (United States); Zhu, X. Ronald; Zhang, Xiaodong, E-mail: xizhang@mdanderson.org [Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030 (United States)

    2015-03-30

    Purpose: This study investigates potential gains of an improved beam angle arrangement compared to a conventional fixed gantry setup in intensity modulated proton therapy (IMPT) treatment for localized prostate cancer patients based on a proof of principle study. Materials and Methods: Three patients with localized prostate cancer retrospectively selected from our institution were studied. For each patient, IMPT plans were designed using two, three and four beam angles, respectively, obtained from a beam angle optimization algorithm. Those plans were then compared with ones using two lateral parallel-opposed beams according to the conventional planning protocol for localized prostate cancer adopted at our institution. Results: IMPT plans with two optimized angles achieved significant improvements in rectum sparing and moderate improvements in bladder sparing against those with two lateral angles. Plans with three optimized angles further improved rectum sparing significantly over those two-angle plans, whereas four-angle plans found no advantage over three-angle plans. A possible three-beam class solution for localized prostate patients was suggested and demonstrated with preserved dosimetric benefits because individually optimized three-angle solutions were found sharing a very similar pattern. Conclusions: This study has demonstrated the potential of using an improved beam angle arrangement to better exploit the theoretical dosimetric benefits of proton therapy and provided insights of selecting quality beam angles for localized prostate cancer treatment.

  20. Improved Beam Angle Arrangement in Intensity Modulated Proton Therapy Treatment Planning for Localized Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Wenhua Cao

    2015-03-01

    Full Text Available Purpose: This study investigates potential gains of an improved beam angle arrangement compared to a conventional fixed gantry setup in intensity modulated proton therapy (IMPT treatment for localized prostate cancer patients based on a proof of principle study. Materials and Methods: Three patients with localized prostate cancer retrospectively selected from our institution were studied. For each patient, IMPT plans were designed using two, three and four beam angles, respectively, obtained from a beam angle optimization algorithm. Those plans were then compared with ones using two lateral parallel-opposed beams according to the conventional planning protocol for localized prostate cancer adopted at our institution. Results: IMPT plans with two optimized angles achieved significant improvements in rectum sparing and moderate improvements in bladder sparing against those with two lateral angles. Plans with three optimized angles further improved rectum sparing significantly over those two-angle plans, whereas four-angle plans found no advantage over three-angle plans. A possible three-beam class solution for localized prostate patients was suggested and demonstrated with preserved dosimetric benefits because individually optimized three-angle solutions were found sharing a very similar pattern. Conclusions: This study has demonstrated the potential of using an improved beam angle arrangement to better exploit the theoretical dosimetric benefits of proton therapy and provided insights of selecting quality beam angles for localized prostate cancer treatment.

  1. Improved Beam Angle Arrangement in Intensity Modulated Proton Therapy Treatment Planning for Localized Prostate Cancer

    International Nuclear Information System (INIS)

    Purpose: This study investigates potential gains of an improved beam angle arrangement compared to a conventional fixed gantry setup in intensity modulated proton therapy (IMPT) treatment for localized prostate cancer patients based on a proof of principle study. Materials and Methods: Three patients with localized prostate cancer retrospectively selected from our institution were studied. For each patient, IMPT plans were designed using two, three and four beam angles, respectively, obtained from a beam angle optimization algorithm. Those plans were then compared with ones using two lateral parallel-opposed beams according to the conventional planning protocol for localized prostate cancer adopted at our institution. Results: IMPT plans with two optimized angles achieved significant improvements in rectum sparing and moderate improvements in bladder sparing against those with two lateral angles. Plans with three optimized angles further improved rectum sparing significantly over those two-angle plans, whereas four-angle plans found no advantage over three-angle plans. A possible three-beam class solution for localized prostate patients was suggested and demonstrated with preserved dosimetric benefits because individually optimized three-angle solutions were found sharing a very similar pattern. Conclusions: This study has demonstrated the potential of using an improved beam angle arrangement to better exploit the theoretical dosimetric benefits of proton therapy and provided insights of selecting quality beam angles for localized prostate cancer treatment

  2. Establishment of Fe-filtered beam facility and measurement of the filtered neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Kobayashi, Katsuhei; Yoshimoto, Takaaki; Fujita, Yoshiaki; Utsuro, Masahiko; Utsumi, Hiroshi [Kyoto Univ., Osaka (Japan); Kudo, Katsuhisa; Takeda, Naoto [Electrotechnical Laboratory, Ibaraki (Japan)

    1998-08-01

    An Fe-filtered neutron beam facility has been installed at the B-1 experimental hole of the Kyoto University Reactor (KUR) at Research Reactor Institute, Kyoto University (KURRI). By making the reactor neutrons penetrating through the thick Fe (45 cm) and Al (35 cm) plates, Fe-filtered beam at 24 keV can be produced. To characterize the Fe-filtered beam facility, following experiments and calculations have been performed: (1) H{sub 2} or He-3 gas counter was applied to measure the Fe-filtered beam neutrons at 24 keV and the result was compared with those by foil-activation data and MCNP calculations. (2) The absolute neutron flux/spectrum was analyzed by eleven activation data using the NEUPAC code. Initial neutron spectrum for the analysis was obtained by the transport calculations using the MCNP code. In the adjusted neutron spectrum, the 24 keV peak spectrum was clearly observed with less neutrons in the higher and the lower energy regions. (3) The neutron flux at 24 keV was also measured with the {sup 197}Au(n,gamma) {sup 198}Au reaction by making use of seven sheets of sandwiched Au foils (each foil was 12.7 mm in diameter and 50 micro-meter thick). The effective cross sections for neutrons from 20 to 28 keV were calculated in each sandwiched Au foil by applying the Fe-filtered beam spectrum as a weighting function. The resultant neutron flux at 24 keV was about 6.7x10{sup 6} n/cm{sup 2}/s, which was close to that measured by the H{sub 2} gas counter.

  3. A nuclear physics program at the Rare Isotope Beams Accelerator Facility in Korea

    Directory of Open Access Journals (Sweden)

    Chang-Bum Moon

    2014-02-01

    Full Text Available This paper outlines the new physics possibilities that fall within the field of nuclear structure and astrophysics based on experiments with radioactive ion beams at the future Rare Isotope Beams Accelerator facility in Korea. This ambitious multi-beam facility has both an Isotope Separation On Line (ISOL and fragmentation capability to produce rare isotopes beams (RIBs and will be capable of producing and accelerating beams of wide range mass of nuclides with energies of a few to hundreds MeV per nucleon. The large dynamic range of reaccelerated RIBs will allow the optimization in each nuclear reaction case with respect to cross section and channel opening. The low energy RIBs around Coulomb barrier offer nuclear reactions such as elastic resonance scatterings, one or two particle transfers, Coulomb multiple-excitations, fusion-evaporations, and direct capture reactions for the study of the very neutron-rich and proton-rich nuclides. In contrast, the high energy RIBs produced by in-flight fragmentation with reaccelerated ions from the ISOL enable to explore the study of neutron drip lines in intermediate mass regions. The proposed studies aim at investigating the exotic nuclei near and beyond the nucleon drip lines, and to explore how nuclear many-body systems change in such extreme regions by addressing the following topics: the evolution of shell structure in areas of extreme proton to neutron imbalance; the study of the weak interaction in exotic decay schemes such as beta-delayed two-neutron or two-proton emission; the change of isospin symmetry in isobaric mirror nuclei at the drip lines; two protons or two neutrons radioactivity beyond the drip lines; the role of the continuum states including resonant states above the particle-decay threshold in exotic nuclei; and the effects of nuclear reaction rates triggered by the unbound proton-rich nuclei on nuclear astrophysical processes.

  4. Beam-centric algorithm for pretreatment patient position correction in external beam radiation therapy

    International Nuclear Information System (INIS)

    Purpose: In current image guided pretreatment patient position adjustment methods, image registration is used to determine alignment parameters. Since most positioning hardware lacks the full six degrees of freedom (DOF), accuracy is compromised. The authors show that such compromises are often unnecessary when one models the planned treatment beams as part of the adjustment calculation process. The authors present a flexible algorithm for determining optimal realizable adjustments for both step-and-shoot and arc delivery methods. Methods: The beam shape model is based on the polygonal intersection of each beam segment with the plane in pretreatment image volume that passes through machine isocenter perpendicular to the central axis of the beam. Under a virtual six-DOF correction, ideal positions of these polygon vertices are computed. The proposed method determines the couch, gantry, and collimator adjustments that minimize the total mismatch of all vertices over all segments with respect to their ideal positions. Using this geometric error metric as a function of the number of available DOF, the user may select the most desirable correction regime. Results: For a simulated treatment plan consisting of three equally weighted coplanar fixed beams, the authors achieve a 7% residual geometric error (with respect to the ideal correction, considered 0% error) by applying gantry rotation as well as translation and isocentric rotation of the couch. For a clinical head-and-neck intensity modulated radiotherapy plan with seven beams and five segments per beam, the corresponding error is 6%. Correction involving only couch translation (typical clinical practice) leads to a much larger 18% mismatch. Clinically significant consequences of more accurate adjustment are apparent in the dose volume histograms of target and critical structures. Conclusions: The algorithm achieves improvements in delivery accuracy using standard delivery hardware without significantly increasing

  5. Power Burst Facility/Boron Neutron Capture Therapy Program for cancer treatment

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, A.L. (ed.); Dorn, R.V. III.

    1990-08-01

    This report discusses monthly progress in the Power Boron Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program for Cancer Treatment. Highlights of the PBF/BNCT Program during August 1990 include progress within the areas of: Gross Boron Analysis in Tissue, Blood, and Urine, boron microscopic (subcellular) analytical development, noninvasive boron quantitative determination, analytical radiation transport and interaction modeling for BNCT, large animal model studies, neutron source and facility preparation, administration and common support and PBF operations.

  6. Dosimetric Audits of Photon Beams in Radiation Therapy Centres

    International Nuclear Information System (INIS)

    Data related to eleven years of high-energy photon radiotherapy beams dosimetry are presented and analyzed. Dosimetric evaluations were carried out using water phantoms and thimble ionization chambers. Measurements were done at reference conditions for a standard absorbed dose of 100 cGy. The first dosimetry surveys from 1996 to 1998 showed deviations of 22% and 18.7%, although small deviations were also obtained. After 1998 the improvement of dosimetry quality control by the radiotherapy centers became clear, with most of the deviations situated within the ±3% range. (author)

  7. Proton therapy beam dosimetry with silicon CMOS image sensors

    International Nuclear Information System (INIS)

    In a previous publication, it has been shown how neutron and proton beams in a quite broad energy interval, could be simply monitored with a position sensitive CMOS image detector. The direct read out, the lack of pile up effects, the stability of the signal, the detector linear response with proton energy and current and the very low costs of the device could make the CMOS detector a good candidate in addition to other well established detectors for proton radiation dosimetry. (N.T.)

  8. Nuclear Physics Programs for the Future Rare Isotope Beams Accelerator Facility in Korea

    CERN Document Server

    Moon, Chang-Bum

    2016-01-01

    We present nuclear physics programs based on the planned experiments using rare isotope beams (RIBs) for the future Korean Rare Isotope Beams Accelerator facility; RAON. This ambitious facility has both an Isotope Separation On Line (ISOL) and fragmentation capability for producing RIBs and accelerating beams of wide range mass of nuclides with energies of a few to hundreds MeV per nucleon. Low energy RIBs at Elab = 5 to 20 MeV per nucleon are for the study of nuclear structure and nuclear astrophysics toward and beyond the drip lines while higher energy RIBs produced by in-flight fragmentation with the re-accelerated ions from the ISOL enable to explore the neutron drip lines in intermediate mass regions. The planned programs have goals for investigating nuclear structures of the exotic nuclei toward and beyond the nucleon drip lines by addressing the following issues: how the shell structure evolves in areas of extreme proton to neutron imbalance; whether the isospin symmetry maintains in isobaric mirror nu...

  9. Beam Dynamics Studies and Design Optimisation of New Low Energy Antiproton Facilities

    CERN Document Server

    Resta-Lopez, Javier; Welsch, Carsten P

    2016-01-01

    Antiprotons, stored and cooled at low energies in a storage ring or at rest in traps, are highly desirable for the investigation of a large number of basic questions on fundamental interactions. This includes the static structure of antiprotonic atomic systems and the time-dependent quantum dynamics of correlated systems. The Antiproton Decelerator (AD) at CERN is currently the worlds only low energy antiproton factory dedicated to antimatter experiments. New antiproton facilities, such as the Extra Low ENergy Antiproton ring (ELENA) at CERN and the Ultra-low energy Storage Ring (USR) at FLAIR, will open unique possibilities. They will provide cooled, high quality beams of extra-low energy antiprotons at intensities exceeding those achieved presently at the AD by factors of ten to one hundred. These facilities, operating in the energy regime between 100 keV down to 20 keV, face several design and beam dynamics challenges, for example nonlinearities, space charge and scattering effects limiting beam life time....

  10. The new vertical neutron beam line at the CERN n-TOF facility design and outlook on the performance

    International Nuclear Information System (INIS)

    At the neutron time-of-flight facility n-TOF at CERN a new vertical beam line was constructed in 2014, in order to extend the experimental possibilities at this facility to an even wider range of challenging cross-section measurements of interest in astrophysics, nuclear technology and medical physics. The design of the beam line and the experimental hall was based on FLUKA Monte Carlo simulations, aiming at maximizing the neutron flux, reducing the beam halo and minimizing the background from neutrons interacting with the collimator or back-scattered in the beam dump. The present paper gives an overview on the design of the beam line and the relevant elements and provides an outlook on the expected performance regarding the neutron beam intensity, shape and energy resolution, as well as the neutron and photon backgrounds

  11. The new vertical neutron beam line at the CERN n-TOF facility design and outlook on the performance

    Energy Technology Data Exchange (ETDEWEB)

    Weiß, C., E-mail: christina.weiss@cern.ch [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Chiaveri, E.; Girod, S.; Vlachoudis, V.; Aberle, O. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Barros, S. [Instituto Tecnológico e Nuclear, Instituto Superior Técnico, Universidade Técnica de Lisboa, Lisboa (Portugal); Bergström, I. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Berthoumieux, E. [Commissariat à l’Énergie Atomique (CEA) Saclay – Irfu, Gif-sur-Yvette (France); Calviani, M. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Guerrero, C.; Sabaté-Gilarte, M. [Universidad de Sevilla (Spain); European Organization for Nuclear Research (CERN), Geneva (Switzerland); Tsinganis, A. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); National Technical University of Athens (NTUA) (Greece); Andrzejewski, J. [Uniwersytet Łódzki, Lodz (Poland); Audouin, L. [Centre National de la Recherche Scientifique/IN2P3 – IPN, Orsay (France); Bacak, M. [Atominstitut, Technische Universität Wien (Austria); Balibrea-Correa, J. [Centro de Investigaciones Energeticas Medioambientales y Tecnológicas (CIEMAT), Madrid (Spain); Barbagallo, M. [Istituto Nazionale di Fisica Nucleare, Bari (Italy); Bécares, V. [Centro de Investigaciones Energeticas Medioambientales y Tecnológicas (CIEMAT), Madrid (Spain); and others

    2015-11-01

    At the neutron time-of-flight facility n-TOF at CERN a new vertical beam line was constructed in 2014, in order to extend the experimental possibilities at this facility to an even wider range of challenging cross-section measurements of interest in astrophysics, nuclear technology and medical physics. The design of the beam line and the experimental hall was based on FLUKA Monte Carlo simulations, aiming at maximizing the neutron flux, reducing the beam halo and minimizing the background from neutrons interacting with the collimator or back-scattered in the beam dump. The present paper gives an overview on the design of the beam line and the relevant elements and provides an outlook on the expected performance regarding the neutron beam intensity, shape and energy resolution, as well as the neutron and photon backgrounds.

  12. High power test of an injector linac for heavy ion cancer therapy facilities

    Science.gov (United States)

    Lu, Liang; Hattori, Toshiyuki; Zhao, Huanyu; Kawasaki, Katsunori; Sun, Liangting; He, Yuan; Zhao, Hongwei

    2015-11-01

    A hybrid single cavity (HSC) linac, combined with radio frequency quadrupole and drift tube structure in a single interdigital-H cavity, operates with high rf power as a prototype injector for cancer therapy synchrotron. The HSC adopts a direct plasma injection scheme (DPIS) with a laser ion source. The input beam current of the HSC is designed to be 20 mA C6 + ions. According to simulations, the HSC can accelerate a 6-mA C6 + beam which meets the requirement of the particle number for cancer therapy (1 08 ˜9 ions/pulse ). The HSC injector with DPIS makes the existing multiturn injection system and stripping system unnecessary; what is more, it can also bring down the size of the beam pipe in existing synchrotron magnets, which can reduce the whole cost of the synchrotron. Details of the field measurements of the HSC linac and results of the high power test are reported in this paper.

  13. Programmable extraction of different energy proton beam to an experimental facility in the process of injection into the IHEP synchrotron

    International Nuclear Information System (INIS)

    The programmable different energy proton beam extraction to an experimental facility of the IHEP under injection to the IHEP proton synchrotron is realized in the following way; after inquiry from the IHEP EF transfer to a lower extraction energy and beam extraction to EF are performed. 1 ref.; 1 fig

  14. Progress in the realization of the PRIMA neutral beam test facility

    Science.gov (United States)

    Toigo, V.; Boilson, D.; Bonicelli, T.; Piovan, R.; Hanada, M.; Chakraborty, A.; Agarici, G.; Antoni, V.; Baruah, U.; Bigi, M.; Chitarin, G.; Dal Bello, S.; Decamps, H.; Graceffa, J.; Kashiwagi, M.; Hemsworth, R.; Luchetta, A.; Marcuzzi, D.; Masiello, A.; Paolucci, F.; Pasqualotto, R.; Patel, H.; Pomaro, N.; Rotti, C.; Serianni, G.; Simon, M.; Singh, M.; Singh, N. P.; Svensson, L.; Tobari, H.; Watanabe, K.; Zaccaria, P.; Agostinetti, P.; Agostini, M.; Andreani, R.; Aprile, D.; Bandyopadhyay, M.; Barbisan, M.; Battistella, M.; Bettini, P.; Blatchford, P.; Boldrin, M.; Bonomo, F.; Bragulat, E.; Brombin, M.; Cavenago, M.; Chuilon, B.; Coniglio, A.; Croci, G.; Dalla Palma, M.; D'Arienzo, M.; Dave, R.; De Esch, H. P. L.; De Lorenzi, A.; De Muri, M.; Delogu, R.; Dhola, H.; Fantz, U.; Fellin, F.; Fellin, L.; Ferro, A.; Fiorentin, A.; Fonnesu, N.; Franzen, P.; Fröschle, M.; Gaio, E.; Gambetta, G.; Gomez, G.; Gnesotto, F.; Gorini, G.; Grando, L.; Gupta, V.; Gutierrez, D.; Hanke, S.; Hardie, C.; Heinemann, B.; Kojima, A.; Kraus, W.; Maeshima, T.; Maistrello, A.; Manduchi, G.; Marconato, N.; Mico, G.; Moreno, J. F.; Moresco, M.; Muraro, A.; Muvvala, V.; Nocentini, R.; Ocello, E.; Ochoa, S.; Parmar, D.; Patel, A.; Pavei, M.; Peruzzo, S.; Pilan, N.; Pilard, V.; Recchia, M.; Riedl, R.; Rizzolo, A.; Roopesh, G.; Rostagni, G.; Sandri, S.; Sartori, E.; Sonato, P.; Sottocornola, A.; Spagnolo, S.; Spolaore, M.; Taliercio, C.; Tardocchi, M.; Thakkar, A.; Umeda, N.; Valente, M.; Veltri, P.; Yadav, A.; Yamanaka, H.; Zamengo, A.; Zaniol, B.; Zanotto, L.; Zaupa, M.

    2015-08-01

    The ITER project requires additional heating by two neutral beam injectors, each accelerating to 1 MV a 40 A beam of negative deuterium ions, to deliver to the plasma a power of about 17 MW for one hour. As these requirements have never been experimentally met, it was recognized as necessary to setup a test facility, PRIMA (Padova Research on ITER Megavolt Accelerator), in Italy, including a full-size negative ion source, SPIDER, and a prototype of the whole ITER injector, MITICA, aiming to develop the heating injectors to be installed in ITER. This realization is made with the main contribution of the European Union, through the Joint Undertaking for ITER (F4E), the ITER Organization and Consorzio RFX which hosts the Test Facility. The Japanese and the Indian ITER Domestic Agencies (JADA and INDA) participate in the PRIMA enterprise; European laboratories, such as IPP-Garching, KIT-Karlsruhe, CCFE-Culham, CEA-Cadarache and others are also cooperating. Presently, the assembly of SPIDER is on-going and the MITICA design is being completed. The paper gives a general overview of the test facility and of the status of development of the MITICA and SPIDER main components at this important stage of the overall development; then it focuses on the latest and most critical issues, regarding both physics and technology, describing the identified solutions.

  15. The influence of lateral beam profile modifications in scanned proton and carbon ion therapy: a Monte Carlo study

    CERN Document Server

    Parodi, K; Kraemer, M; Sommerer, F; Naumann, J; Mairani, A; Brons, S

    2010-01-01

    Scanned ion beam delivery promises superior flexibility and accuracy for highly conformal tumour therapy in comparison to the usage of passive beam shaping systems. The attainable precision demands correct overlapping of the pencil-like beams which build up the entire dose distribution in the treatment field. In particular, improper dose application due to deviations of the lateral beam profiles from the nominal planning conditions must be prevented via appropriate beam monitoring in the beamline, prior to the entrance in the patient. To assess the necessary tolerance thresholds of the beam monitoring system at the Heidelberg Ion Beam Therapy Center, Germany, this study has investigated several worst-case scenarios for a sensitive treatment plan, namely scanned proton and carbon ion delivery to a small target volume at a shallow depth. Deviations from the nominal lateral beam profiles were simulated, which may occur because of misaligned elements or changes of the beam optic in the beamline. Data have been an...

  16. Medical cyclotron facilities

    International Nuclear Information System (INIS)

    This report examines the separate proposals from the Austin Hospital and the Australian Atomic Energy Commission for a medical cyclotron facility. The proponents have argued that a cyclotron facility would benefit Australia in areas of patient care, availability and export of radioisotopes, and medical research. Positron emission tomography (PET) and neutron beam therapy are also examined

  17. High power transcranial beam steering for ultrasonic brain therapy.

    OpenAIRE

    PERNOT, mathieu; Aubry, Jean-François; Tanter, Mickaël; Thomas, Jean-Louis; Fink, Mathias

    2003-01-01

    International audience A sparse phased array is specially designed for non-invasive ultrasound transskull brain therapy. The array is made of 200 single elements corresponding to a new generation of high power transducers developed in collaboration with Imasonic (Besançon, France). Each element has a surface of 0.5 cm2 and works at 0.9 MHz central frequency with a maximum 20 W cm(-2) intensity on the transducer surface. In order to optimize the steering capabilities of the array, several t...

  18. Fluorescent nuclear track detectors as a tool for ion-beam therapy research

    International Nuclear Information System (INIS)

    Fluorescent nuclear track detectors based on Al2O3:C,Mg with their excellent efficiency for detection of heavy charged particles and full 3D information from laser scanning microscopy allow a multitude of issues related to ion-beam cancer therapy to be tackled. A recently established read out protocol enables the utilization of a commercial microscope similar to those available in many life-science environments. This contribution illustrates the approach, its potential and limitations, as well as applications in clinical ion beams. -- Highlights: ► Fluorescent nuclear track detectors (FNTDs) are based on alumina. ► They represent a unique research tool for ion beam cancer therapy. ► We present a protocol for FNTD read out using a commercial laser scanning microscope

  19. Cost-effectiveness analysis of cochlear dose reduction by proton beam therapy for medulloblastoma in childhood

    International Nuclear Information System (INIS)

    The aim of this study is to evaluate the cost-effectiveness of proton beam therapy with cochlear dose reduction compared with conventional X-ray radiotherapy for medulloblastoma in childhood. We developed a Markov model to describe health states of 6-year-old children with medulloblastoma after treatment with proton or X-ray radiotherapy. The risks of hearing loss were calculated on cochlear dose for each treatment. Three types of health-related quality of life (HRQOL) of EQ-5D, HUI3 and SF-6D were used for estimation of quality-adjusted life years (QALYs). The incremental cost-effectiveness ratio (ICER) for proton beam therapy compared with X-ray radiotherapy was calculated for each HRQOL. Sensitivity analyses were performed to model uncertainty in these parameters. The ICER for EQ-5D, HUI3 and SF-6D were $21 716/QALY, $11 773/QALY, and $20 150/QALY, respectively. One-way sensitivity analyses found that the results were sensitive to discount rate, the risk of hearing loss after proton therapy, and costs of proton irradiation. Cost-effectiveness acceptability curve analysis revealed a 99% probability of proton therapy being cost effective at a societal willingness-to-pay value. Proton beam therapy with cochlear dose reduction improves health outcomes at a cost that is within the acceptable cost-effectiveness range from the payer's standpoint. (author)

  20. Normal tissue tolerance to external beam radiation therapy: Skin

    International Nuclear Information System (INIS)

    Acute skin toxicity is frequent during radiation therapy and can lead to temporary arrest of the treatment. Chronic toxicity can occur and conduct to cosmetic problems. Alopecia is the most frequent toxicity concerning hair and is most of the time reversible. Several factors linked to patients influence skin toxicity, such as under-nutrition, old age, obesity, smoking, skin diseases, autoimmune diseases, failure of DNA reparation. Skin, hair and nail toxicities depend also on radiation schedule. Acute toxicity is greater when dose per fraction increases. Chronic and acute toxicities are more often when total dose increases. Under 45 Gy, the risk of severe skin toxicity is low, and begins above 50 Gy. Skin toxicity depends also on the duration of radiotherapy and split course schedules are associated with less toxicities. Irradiation surface seems to influence skin toxicity but interaction is more complex. Reirradiation is often feasible in case of cancer recurrence but with a risk of grade 3-4 toxicity above all in head and neck cancer. The benefit/risk ratio has to be always precisely evaluated. Permanent alopecia is correlated with the follicle dose. Modern techniques of radiation therapy allow to spare skin. (authors)

  1. Analysis of beam on target interaction in a neutron-source test facility

    International Nuclear Information System (INIS)

    The need is urgent for a high-flux, high-energy neutron test facility to evaluate the performance of fusion reactor materials. An accelerator-based deuterium-lithium source is generally considered the most reasonable approach to a high-flux neutron source in the near future. The idea is to bombard a high-energy (20--40 MeV) deuteron beam into a lithium jet target to produce high-energy neutrons in order to simulate a fusion reactor environment via the Li (d,n) nuclear stripping reaction. Deposition of the high-energy deuteron beam and the subsequent response of the lithium jet are modeled and evaluated in detail. To assess the feasibility of this concept, the analysis is done parametrically for various deuteron beam energies, beam currents, and jet velocities. A main requirement for a successful operation is to keep the free jet surface at a minimum temperature to reduce surface evaporation of lithium into the vacuum system. The effects of neutron-generated heating and irradiation on the jet-supporting back plate are also evaluated. The back plate must maintain a reasonable lifetime during system operation

  2. Prompt gamma ray activation analysis using neutron beam from THOR facility

    International Nuclear Information System (INIS)

    A reactor-based facility for neutron-capture prompt gamma-ray spectrometry for activation analysis has been installed at the one megawatt Tsing Hua Open-pool Reactor. The system consists a neutron beam port with collimators, irradiation stand, external beam tube, neutron beam dump, and counting system. The counting system consists of a 25 % n-type high purity germanium main gamma-ray detector, a 9'' x 10'' NaI(T1) anti-Compton detector shield, and Compton-suppressed electronics coupled to the CANBERRA S-88 Multi-parameter analyzer. Although the neutron beam at the sample irradiation station has an intensity of only 1,300,000 n/cm2s with a cadmium ratio of 26 : 1, the background levels of the on-line measurement in the mixed neutron/gamma field are sufficiently low, resulting a satisfactory detection of many elemental composition in samples. The lower limits of detection of 35 elements in sample matrix of the present system and the current applications are discussed. (author)

  3. Analysis of beam-on-target interaction in a neutron-source test facility

    International Nuclear Information System (INIS)

    The need is urgent for a high-flux, high-energy neutron test facility to evaluate the performance of fusion reactor materials. An accelerator-based deuterium-lithium source is generally considered the most reasonable approach to a high-flux neutron source in the near future. The idea is to bombard a high-energy (20--40 MeV) deuteron beam into a lithium jet target to produce high-energy neutrons in order to simulate a fusion reactor environment via the Li (d, n) nuclear stripping reaction. Deposition of the high-energy deuteron beam and the subsequent response of the lithium jet are modeled and evaluated in detail. To assess the feasibility of this concept, the analysis is done parametrically for various deuteron beam energies, beam currents, and jet velocities. A main requirement for a successful operation is to keep the free jet surface at a minimum temperature to reduce surface evaporation of lithium into the vacuum system. The effects of neutron-generated heating and irradiation on the jet-supporting back plate are also evaluated. The back plate must maintain a reasonable lifetime during system operation

  4. Experimental fragmentation studies with 12C therapy beams

    International Nuclear Information System (INIS)

    High-energy beams of 12C ions in the range of 80-430 MeV u-1 delivered by the heavy-ion synchrotron SIS-18 are used for radiotherapy of deep-seated localized tumors at the treatment unit at GSI Darmstadt. In order to improve the physical database, the fragmentation characteristics along the penetration path in tissue were investigated experimentally by using a water phantom as tissue-equivalent absorber. Measurements were performed at specific energies of 200 and 400 MeV u-1 of the incident 12C ions and at six different depths before and behind the Bragg peak. Secondary fragments with nuclear charges Zf = 1-5 were identified by scintillation detectors using ΔE-E and time-of-flight techniques. The preliminary results include energy- and angular distributions, fragment yields, build-up curves and attenuation of the primary carbon projectiles. (authors)

  5. Dynamic Target Definition: A novel approach for PTV definition in ion beam therapy

    International Nuclear Information System (INIS)

    Purpose: To present a beam arrangement specific approach for PTV definition in ion beam therapy. Materials and methods: By means of a Monte Carlo error propagation analysis a criteria is formulated to assess whether a voxel is safely treated. Based on this a non-isotropical expansion rule is proposed aiming to minimize the impact of uncertainties on the dose delivered. Results: The method is exemplified in two cases: a Head and Neck case and a Prostate case. In both cases the modality used is proton beam irradiation and the sources of uncertainties taken into account are positioning (set up) errors and range uncertainties. It is shown how different beam arrangements have an impact on plan robustness which leads to different target expansions necessary to assure a predefined level of plan robustness. The relevance of appropriate beam angle arrangements as a way to minimize uncertainties is demonstrated. Conclusions: A novel method for PTV definition in on beam therapy is presented. The method show promising results by improving the probability of correct dose CTV coverage while reducing the size of the PTV volume. In a clinical scenario this translates into an enhanced tumor control probability while reducing the volume of healthy tissue being irradiated

  6. The ion beam sputtering facility at KURRI: Coatings for advanced neutron optical devices

    Energy Technology Data Exchange (ETDEWEB)

    Hino, Masahiro, E-mail: hino@rri.kyoto-u.ac.jp [Research Reactor Institute, Kyoto university, Kumatori, Osaka 590-0494 (Japan); Oda, Tatsuro [Department of Nuclear Engineering, Kyoto University, Kyoto 615-8540 (Japan); Kitaguchi, Masaaki [Center for Experimental Studies, KMI, Nagoya University, Nagoya 464-8602 (Japan); Yamada, Norifumi L. [Neutron Science Laboratory, High Energy Accelerator Research Organization, 203-1 Shirakata, Tokai, Ibaraki 319-1106 (Japan); Tasaki, Seiji [Department of Nuclear Engineering, Kyoto University, Kyoto 615-8540 (Japan); Kawabata, Yuji [Research Reactor Institute, Kyoto university, Kumatori, Osaka 590-0494 (Japan)

    2015-10-11

    We describe a film coating facility for the development of multilayer mirrors for use in neutron optical devices that handle slow neutron beams. Recently, we succeeded in fabricating a large neutron supermirror with high reflectivity using an ion beam sputtering system (KUR-IBS), as well as all neutron supermirrors in two neutron guide tubes at BL06 at J-PARC/MLF. We also realized a large flexible self-standing m=5 NiC/Ti supermirror and very small d-spacing (d=1.65 nm) multilayer sheets. In this paper, we present an overview of the performance and utility of non-magnetic neutron multilayer mirrors fabricated with the KUR-IBS.

  7. Nuclear Theory and Science of the Facility for Rare Isotope Beams

    CERN Document Server

    Balantekin, A B; Dean, D J; Fuller, G M; Furnstahl, R J; Hjorth-Jensen, M; Janssens, R V F; Li, Bao-An; Nazarewicz, W; Nunes, F M; Ormand, W E; Reddy, S; Sherrill, B M

    2014-01-01

    The Facility for Rare Isotope Beams (FRIB) will be a world-leading laboratory for the study of nuclear structure, reactions and astrophysics. Experiments with intense beams of rare isotopes produced at FRIB will guide us toward a comprehensive description of nuclei, elucidate the origin of the elements in the cosmos, help provide an understanding of matter in neutron stars, and establish the scientific foundation for innovative applications of nuclear science to society. FRIB will be essential for gaining access to key regions of the nuclear chart, where the measured nuclear properties will challenge established concepts, and highlight shortcomings and needed modifications to current theory. Conversely, nuclear theory will play a critical role in providing the intellectual framework for the science at FRIB, and will provide invaluable guidance to FRIB's experimental programs. This article overviews the broad scope of the FRIB theory effort, which reaches beyond the traditional fields of nuclear structure and ...

  8. Status of PRIMA, the test facility for ITER neutral beam injectors

    Science.gov (United States)

    Sonato, P.; Antoni, V.; Bigi, M.; Chitarin, G.; Luchetta, A.; Marcuzzi, D.; Pasqualotto, R.; Pomaro, N.; Serianni, G.; Toigo, V.; Zaccaria, P.; ITER International Team

    2013-02-01

    The ITER project requires additional heating by two neutral beam injectors, each accelerating to 1MV a 40A beam of negative deuterons, delivering to the plasma about 17MW up to one hour. As these requirements have never been experimentally met, it was decided to build a test facility, PRIMA (Padova Research on ITER Megavolt Accelerator), in Italy, including a full-size negative ion source, SPIDER, and a prototype of the whole ITER injector, MITICA, aiming to develop the heating injectors to be installed in ITER. The Japan and the India Domestic Agencies participate in the PRIMA enterprise; European laboratories, such as KIT-Karlsruhe, IPP-Garching, CCFE-Culham, CEA-Cadarache and others are also cooperating. In the paper the main requirements are discussed and the design of the main components and systems are described.

  9. Extremely low vertical-emittance beam in accelerator-test facility at KEK

    International Nuclear Information System (INIS)

    Electron beams with the lowest, normalized transverse emittance recorded so far were produced and confirmed in single-bunch-mode operation of the Accelerator Test Facility at KEK. We established a tuning method of the damping rings which achieves a small vertical dispersion and small x-y orbit coupling. The vertical emittance was less than 1 percent of the horizontal emittance. At the zero-intensity limit, the vertical normalized emittance was less than 2.8 x 10-8 rad m at beam energy 1.3 GeV. At high intensity, strong effects of intrabeam scattering were observed, which had been expected in view of the extremely high particle density due to the small transverse emittance

  10. Evolutionary genetic optimization of the injector beam dynamics for the ERL test facility at IHEP

    CERN Document Server

    Yi, Jiao

    2013-01-01

    The energy recovery linac test facility (ERL-TF), a compact ERL-FEL (free electron laser) two-purpose machine, was proposed at the Institute of High Energy Physics, Beijing. As one important component of the ERL-TF, the photo-injector started with a photocathode direct-current gun was designed and preliminarily optimized. In this paper an evolutionary genetic method, non-dominated sorting genetic algorithm II, is applied to optimize the injector beam dynamics, especially in the high-charge operation mode. Study shows that using an incident laser with rms transverse size of 1~1.2 mm, the normalized emittance of the electron beam can be kept below 1 mm.mrad at the end of the injector. This work, together with the previous optimization for the low-charge operation mode by using the iterative scan method, provides guidance and confidence for future constructing and commissioning of the ERL-TF injector.

  11. Neutron and gamma-ray streaming calculations for the engineering test facility neutral beam injectors

    International Nuclear Information System (INIS)

    Two-dimensional radiation transport methods have been used to estimate the effects of neutron and gamma-ray streaming on the performance of the Engineering Test Facility neutral beam injectors. The calculations take into account the spatial, angular, and spectral distributions of the radiation entering the injector duct. The instantaneous nuclear heating rate averaged over the length of the cryopumping panel in the injector is 7.5 X 10-3 MW/m3, which implies a total heat load of 2.2 X 10-4 MW. The instantaneous dose rate to the ion gun insulators was estimated to be 3200 rad/s. The radial dependence of the instantaneous dose equivalent rate in the neutral beam injector duct shield was also calculated

  12. Spatial and spectral characteristics of a compact system neutron beam designed for BNCT facility

    International Nuclear Information System (INIS)

    The development of suitable neutron sources and neutron beam is critical to the success of Boron Neutron Capture Therapy (BNCT). In this work a compact system designed for BNCT is presented. The system consists of 252Cf fission neutron source and a moderator/reflector/filter/shield assembly. The moderator/reflector/filter arrangement has been optimized to maximize the epithermal neutron component which is useful for BNCT treatment of deep seated tumors with the suitably low level of beam contamination. The MCMP5 code has been used to calculate the different components of neutrons, secondary gamma rays originating from 252Cf source and the primary gamma rays emitted directly by this source at the exit face of the compact system. The fluence rate distributions of such particles were also computed along the central axis of a human head phantom

  13. Spatial and spectral characteristics of a compact system neutron beam designed for BNCT facility

    Energy Technology Data Exchange (ETDEWEB)

    Ghassoun, J. [EPRA, Departement de Physique, Faculte des Sciences Semlalia, B.P. 2390, 40000 Marrakech (Morocco)], E-mail: ghassoun@ucam.ac.ma; Chkillou, B.; Jehouani, A. [EPRA, Departement de Physique, Faculte des Sciences Semlalia, B.P. 2390, 40000 Marrakech (Morocco)

    2009-04-15

    The development of suitable neutron sources and neutron beam is critical to the success of Boron Neutron Capture Therapy (BNCT). In this work a compact system designed for BNCT is presented. The system consists of {sup 252}Cf fission neutron source and a moderator/reflector/filter/shield assembly. The moderator/reflector/filter arrangement has been optimized to maximize the epithermal neutron component which is useful for BNCT treatment of deep seated tumors with the suitably low level of beam contamination. The MCMP5 code has been used to calculate the different components of neutrons, secondary gamma rays originating from {sup 252}Cf source and the primary gamma rays emitted directly by this source at the exit face of the compact system. The fluence rate distributions of such particles were also computed along the central axis of a human head phantom.

  14. Spatial and spectral characteristics of a compact system neutron beam designed for BNCT facility.

    Science.gov (United States)

    Ghassoun, J; Chkillou, B; Jehouani, A

    2009-04-01

    The development of suitable neutron sources and neutron beam is critical to the success of Boron Neutron Capture Therapy (BNCT). In this work a compact system designed for BNCT is presented. The system consists of (252)Cf fission neutron source and a moderator/reflector/filter/shield assembly. The moderator/reflector/filter arrangement has been optimized to maximize the epithermal neutron component which is useful for BNCT treatment of deep seated tumors with the suitably low level of beam contamination. The MCMP5 code has been used to calculate the different components of neutrons, secondary gamma rays originating from (252)Cf source and the primary gamma rays emitted directly by this source at the exit face of the compact system. The fluence rate distributions of such particles were also computed along the central axis of a human head phantom. PMID:19168369

  15. 4D optimization of scanned ion beam tracking therapy for moving tumors

    Science.gov (United States)

    Eley, John Gordon; Newhauser, Wayne David; Lüchtenborg, Robert; Graeff, Christian; Bert, Christoph

    2014-07-01

    Motion mitigation strategies are needed to fully realize the theoretical advantages of scanned ion beam therapy for patients with moving tumors. The purpose of this study was to determine whether a new four-dimensional (4D) optimization approach for scanned-ion-beam tracking could reduce dose to avoidance volumes near a moving target while maintaining target dose coverage, compared to an existing 3D-optimized beam tracking approach. We tested these approaches computationally using a simple 4D geometrical phantom and a complex anatomic phantom, that is, a 4D computed tomogram of the thorax of a lung cancer patient. We also validated our findings using measurements of carbon-ion beams with a motorized film phantom. Relative to 3D-optimized beam tracking, 4D-optimized beam tracking reduced the maximum predicted dose to avoidance volumes by 53% in the simple phantom and by 13% in the thorax phantom. 4D-optimized beam tracking provided similar target dose homogeneity in the simple phantom (standard deviation of target dose was 0.4% versus 0.3%) and dramatically superior homogeneity in the thorax phantom (D5-D95 was 1.9% versus 38.7%). Measurements demonstrated that delivery of 4D-optimized beam tracking was technically feasible and confirmed a 42% decrease in maximum film exposure in the avoidance region compared with 3D-optimized beam tracking. In conclusion, we found that 4D-optimized beam tracking can reduce the maximum dose to avoidance volumes near a moving target while maintaining target dose coverage, compared with 3D-optimized beam tracking.

  16. Fast control and data acquisition in the neutral beam test facility

    Energy Technology Data Exchange (ETDEWEB)

    Luchetta, A., E-mail: adriano.luchetta@igi.cnr.it; Manduchi, G.; Taliercio, C.

    2014-05-15

    Highlights: • The paper describes the fast control and data acquisition in the ITER neutral beam test facility. • The usage of real time control in ion beam generation and extraction is proposed. • Real time management of breakdowns is described. • The implementation of event-driven data acquisition is reported. - Abstract: Fast control and data acquisition are required in the ion source test bed of the ITER neutral beam test facility, referred to as SPIDER. Fast control will drive the operation of the power supply systems with particular reference to special asynchronous events, such as the breakdowns. These are short-circuits among grids or between grids and vessel that can occur repeatedly during beam operation. They are normal events and, as such, they will be managed by the fast control system. Cycle time associated to such fast control is down to hundreds of microseconds. Fast data acquisition is required when breakdowns occur. Event-driven data acquisition is triggered in real time by fast control at the occurrence of each breakdown. Pre- and post-event samples are acquired, allowing capturing information on transient phenomena in a whole time-window centered on the event. Sampling rate of event-driven data acquisition is up to 5 MS/s. Fast data acquisition may also be independent of breakdowns as in the case of the cavity ring-down spectroscopy where data chunks are acquired at 100 MS/s in bursts of 1.5 ms every 100 ms and are processed in real time to produce derived measurements. The paper after the description of the SPIDER fast control and data acquisition application will report the system design based on commercially available hardware and the MARTe and MDSplus software frameworks. The results obtained by running a full prototype of the fast control and data acquisition system are also reported and discussed. They demonstrate that all SPIDER fast control and data acquisition requirements can be met in the prototype solution.

  17. Fast control and data acquisition in the neutral beam test facility

    International Nuclear Information System (INIS)

    Highlights: • The paper describes the fast control and data acquisition in the ITER neutral beam test facility. • The usage of real time control in ion beam generation and extraction is proposed. • Real time management of breakdowns is described. • The implementation of event-driven data acquisition is reported. - Abstract: Fast control and data acquisition are required in the ion source test bed of the ITER neutral beam test facility, referred to as SPIDER. Fast control will drive the operation of the power supply systems with particular reference to special asynchronous events, such as the breakdowns. These are short-circuits among grids or between grids and vessel that can occur repeatedly during beam operation. They are normal events and, as such, they will be managed by the fast control system. Cycle time associated to such fast control is down to hundreds of microseconds. Fast data acquisition is required when breakdowns occur. Event-driven data acquisition is triggered in real time by fast control at the occurrence of each breakdown. Pre- and post-event samples are acquired, allowing capturing information on transient phenomena in a whole time-window centered on the event. Sampling rate of event-driven data acquisition is up to 5 MS/s. Fast data acquisition may also be independent of breakdowns as in the case of the cavity ring-down spectroscopy where data chunks are acquired at 100 MS/s in bursts of 1.5 ms every 100 ms and are processed in real time to produce derived measurements. The paper after the description of the SPIDER fast control and data acquisition application will report the system design based on commercially available hardware and the MARTe and MDSplus software frameworks. The results obtained by running a full prototype of the fast control and data acquisition system are also reported and discussed. They demonstrate that all SPIDER fast control and data acquisition requirements can be met in the prototype solution

  18. Early Commissioning Experience and Future Plans for the 12 GeV Continuous Electron Beam Accelerator Facility

    Energy Technology Data Exchange (ETDEWEB)

    Spata, Michael F. [JLAB

    2014-12-01

    Jefferson Lab has recently completed the accelerator portion of the 12 GeV Upgrade for the Continuous Electron Beam Accelerator Facility. All 52 SRF cryomodules have been commissioned and operated with beam. The initial beam transport goals of demonstrating 2.2 GeV per pass, greater than 6 GeV in 3 passes to an existing experimental facility and greater than 10 GeV in 5-1/2 passes have all been accomplished. These results along with future plans to commission the remaining beamlines and to increase the performance of the accelerator to achieve reliable, robust and efficient operations at 12 GeV are presented.

  19. Gas delivery system and beamline studies for the test beam facility of the Collider Detector at Fermilab

    International Nuclear Information System (INIS)

    A fixed-target test beam facility has been designed and constructed at the Meson Test (MT) site to support studies of components of the Collider Detector at Fermi National Accelerator Laboratory (CDF). I assisted in the design and constuction of the test beam facility gas delivery system, and I conducted the initial studies to document the ability of the MT beamline to meet the needs of CDF. Analysis of the preliminary performance data on MT beamline components and beam tunes at required particle energies is presented. Preliminary studies show that the MT beamline has the necessary flexibility to satisfy most CDF requirements now

  20. CEBAF/SURA [Continuous Electron Beam Accelerator Facility]/[Southeastern Universities Research Association] 1988 summer workshop

    International Nuclear Information System (INIS)

    This report contains papers from a summer workshop of the continuous electron beam accelerator facility. Some topics of these papers are: spectrometers; electron scattering from deuterons; relativistic correlations in nuclear matter; pion production on 3He and 3H; quantum electrodynamic processes in crystals; 12C(e,e'p) x reaction; deuteron polarization tensor and relativistic spin rotation; electromagnetic excitation of nuclei; electron distortion and structure functions in (e,e'p) reactions; and reaction mechanism of 4He(e,e'p)3H

  1. Beam plug replacement and alignment under high radiation conditions for cold neutron facilities at Hanaro

    International Nuclear Information System (INIS)

    Full text : The HANARO, an open-tank-in-pool type research reactor of a 30 MWth power in Korea, has been operating for 15 years since its initial criticality in February 1995. The beam port assigned for the cold neutron at HANARO had been used for an 8-m SANS without neutron guides until it was replaced by a cold neutron guide system in 2008. It was developed a cold neutron guide system for the delivery of cold neutrons from the cold neutron source in the reactor to the neutron scattering instruments in the guide hall. Since the HANARO has been operated from 1995, it was a big challenge to replace the existing plug and shutter with the new facilities under high radiation conditions. When the old plug was removed from the beam port in 2008, the radiation level was 230 mSv/hr at the end of beam port. In addition to that, there were more difficult situations such as the poor as-built dimensions of the beam port, limited work space and time constraint due to other constructions in parallel in the reactor hall. Before the removal of the old plug the level of the radiation was measured coming out through a small hole of the plug to estimate the radiation level during the removal of the old plug and installation of a new plug. Based on the measurement and analysis results, special tools and various shielding facilities were developed for the removal of old in-pile plug and the installation of the new in-pile plug assembly safely. In 2008, the old plug and shutter were successfully replaced by the new plug and shutter as shown in this article with a minimum exposure to the workers. A laser tracker system was also one of the main factors in our successful installation and alignment under high radiation conditions and limited work space. The laser tracker was used to measure and align all the mechanical facilities and the neutron guides with a minimum radiation exposure to workers. The alignment of all the guides and accessories were possible during reactor operation because

  2. Exploratory calculations for boron capture therapy using epithermal neutron beams

    International Nuclear Information System (INIS)

    To get an insight into the problems of boron neutron capture therapy of brain tumours, some calculations of the neutron distribution in a spherical human skull have been made with an ANISN program. The energy of the source neutrons was varied from about 1 keV to about 100 keV. Two different neutron group structures were used with corresponding different cross section libraries. For a spherically symmetric irradiation of a skull with radius 10 cm a source neutron energy of about 50 - 100 keV gives a rather flat boron capture rate over a large part of the skull. This shows the advantage of using epithermal neutrons in the treatment of deepseated tumours by the boron neutron capture method. (Auth.)

  3. SU-E-J-49: Distal Edge Activity Fall Off Of Proton Therapy Beams

    Energy Technology Data Exchange (ETDEWEB)

    Elmekawy, A; Ewell, L [Hampton University, Hampton, VA (United States); Butuceanu, C; Zhu, L [HUPTI, Hampton, VA (United States)

    2014-06-01

    Purpose: To characterize and quantify the distal edge activity fall off, created in a phantom by a proton therapy beam Method and Materials: A 30x30x10cm polymethylmethacrylate phantom was irradiated with a proton therapy beam using different ranges and beams. The irradiation volume is approximated by a right circular cylinder of diameter 7.6cm and varying lengths. After irradiation, the phantom was scanned via a Philips Gemini Big Bore™ PET-CT for isotope activation. Varian Eclipse™ treatment planning system as well as ImageJ™ were used to analyze the resulting PET and CT scans. The region of activity within the phantom was longitudinally measured as a function of PET slice number. Dose estimations were made via Monte Carlo (GATE) simulation. Results: For both the spread out Bragg peak (SOBP) and the mono-energetic pristine Bragg peak proton beams, the proximal activation rise was steep: average slope −0.735 (average intensity/slice number) ± 0.091 (standard deviation) for the pristine beams and −1.149 ± 0.117 for the SOBP beams. In contrast, the distal fall offs were dissimilar. The distal fall off in activity for the pristine beams was fit well by a linear curve: R{sup 2} (Pierson Product) was 0.9968, 0.9955 and 0.9909 for the 13.5, 17.0 and 21.0cm range beams respectively. The good fit allows for a slope comparison between the different ranges. The slope varied as a function of range from 1.021 for the 13.5cm beam to 0.8407 (average intensity/slice number) for the 21.0cm beam. This dependence can be characterized: −0.0234(average intensity/slice number/cm range). For the SOBP beams, the slopes were significantly less and were also less linear: average slope 0.2628 ± 0.0474, average R{sup 2}=0.9236. Conclusion: The distal activation fall off edge for pristine proton beams was linear and steep. The corresponding quantities for SOBP beams were shallower and less linear. Philips has provided support for this work.

  4. Beam Test for Evaluating Applicabillity of High - Strength Reinforcement in Structure of Nuclear Facility

    International Nuclear Information System (INIS)

    The high-strength rebar which has high yield strength can reduce the amount of rebar in concrete and widen its spacing so that it has better workability and higher economic benefits for the structure. However, the maximum yield strength of rebar is limited to 420MPa in the design criteria for structure of nuclear facility in Korea and USA. Korea Hydro and Nuclear Power is progressing research to revise the limitation in the yield strength of rebar, which is suggested in the criteria of KEPIC and ACI, in order to apply 550 MPa high-strength rebar for the construction of a nuclear facility. This study is to review the applicability of high strength rebar in structure of a nuclear facility through a model beam test. After reviewing the shear capacity and reinforcement yield to assess the applicability of high-strength reinforcement in the structure of a nuclear facility, we make the following conclusions. When using high shear reinforcement with wider spacing, it has a similar shear capacity to normal reinforcement with narrower spacing. This means better workability and economic benefits can be achieved by widening the rebar spacing without brittle fracture in the elements. For future plans, the results of this test and supplementary test will be submitted to ACI349 committee as backup data to revise the standard for yield strength of high-strength rebar

  5. First experimental-based characterization of oxygen ion beam depth dose distributions at the Heidelberg Ion-Beam Therapy Center

    Science.gov (United States)

    Kurz, C.; Mairani, A.; Parodi, K.

    2012-08-01

    Over the last decades, the application of proton and heavy-ion beams to external beam radiotherapy has rapidly increased. Due to the favourable lateral and depth dose profile, the superposition of narrow ion pencil beams may enable a highly conformal dose delivery to the tumour, with better sparing of the surrounding healthy tissue in comparison to conventional radiation therapy with photons. To fully exploit the promised clinical advantages of ion beams, an accurate planning of the patient treatments is required. The clinical treatment planning system (TPS) at the Heidelberg Ion-Beam Therapy Center (HIT) is based on a fast performing analytical algorithm for dose calculation, relying, among others, on laterally integrated depth dose distributions (DDDs) simulated with the FLUKA Monte Carlo (MC) code. Important input parameters of these simulations need to be derived from a comparison of the simulated DDDs with measurements. In this work, the first measurements of 16O ion DDDs at HIT are presented with a focus on the determined Bragg peak positions and the understanding of factors influencing the shape of the distributions. The measurements are compared to different simulation approaches aiming to reproduce the acquired data at best. A simplified geometrical model is first used to optimize important input parameters, not known a priori, in the simulations. This method is then compared to a more realistic, but also more time-consuming simulation approach better accounting for the experimental set-up and the measuring process. The results of this work contributed to a pre-clinical oxygen ion beam database, which is currently used by a research TPS for corresponding radio-biological cell experiments. A future extension to a clinical database used by the clinical TPS at HIT is foreseen. As a side effect, the performed investigations showed that the typical water equivalent calibration approach of experimental data acquired with water column systems leads to slight

  6. Normal tissue tolerance to external beam radiation therapy: Small bowel

    International Nuclear Information System (INIS)

    The small bowel is a hollow organ involved in the transit and absorption of food. In relation to its anatomical location, a significant amount of this organ is exposed in whole or in part to ionizing radiation in external radiotherapy during abdominal or pelvic irradiation either for primary cancers or metastasis. The acute functional changes during external beam radiation are mainly leading to diarrhea, abdominal pain and bloating. The main late side effects of irradiation of the small intestine are chronic diarrhea, malabsorption with steatorrhoea, abdominal spasms, intestinal obstruction, bleeding and fistulas. The architecture of the small intestine may be considered as parallel with a significant correlation between the irradiated volume of small bowel and the likelihood of acute toxicity, whatever the dose. The literature analysis recommends to consider the volume of small bowel receiving 15 Gy (threshold of 100 to 200 cm3) but also 30 and 50 Gy (thresholds of 35 to 300 cm3, depending on the level of dose considered). Modern techniques of conformal radiotherapy with modulated intensity will probably have beneficial impact on small bowel toxicity. (authors)

  7. Normal tissue tolerance to external beam radiation therapy: The vagina

    International Nuclear Information System (INIS)

    The vagina is a virtual cavity involved in sexual reproduction field. Due to its anatomical location, it may be exposed in whole or in part to ionizing radiation in external radiotherapy and/or brachytherapy of the pelvic region. This review aims to describe the vaginal acute and late side effects due to radiation, probably inadequately reported in the literature. Medline and PubMed literature searches were performed using the keywords -vaginal - radiotherapy - toxicity. The acute and late functional changes after external beam radiation consist mainly of drought. Their incidences are poorly described in the literature and the delivered doses even less. Recommendations are non-existent as the normal tissue complication probability (NTCP). Brachytherapy delivers high and heterogeneous doses, making it difficult to estimate the dose. The concomitant administration of chemotherapy appears to be a factor increasing the risk of toxicity. Modern techniques of conformal radiotherapy with modulated intensity appear to have little impact on this body. Only a maximum dose on each third of the vagina appears to be currently proposed to avoid the risk of side effects. (authors)

  8. International Scoping Study (ISS) for a future neutrino factory and Super-Beam facility. Detectors and flux instrumentation for future neutrino facilities

    International Nuclear Information System (INIS)

    This report summarises the conclusions from the detector group of the International Scoping Study of a future Neutrino Factory and Super-Beam neutrino facility. The baseline detector options for each possible neutrino beam are defined as follows: 1. A very massive (Megaton) water Cherenkov detector is the baseline option for a sub-GeV Beta Beam and Super Beam facility. 2. There are a number of possibilities for either a Beta Beam or Super Beam (SB) medium energy facility between 1-5 GeV. These include a totally active scintillating detector (TASD), a liquid argon TPC or a water Cherenkov detector. 3. A 100 kton magnetized iron neutrino detector (MIND) is the baseline to detect the wrong sign muon final states (golden channel) at a high energy (20-50 GeV) neutrino factory from muon decay. A 10 kton hybrid neutrino magnetic emulsion cloud chamber detector for wrong sign tau detection (silver channel) is a possible complement to MIND, if one needs to resolve degeneracies that appear in the δ-θ13 parameter space.

  9. The Holifield Radioactive Ion Beam Facility at the Oak Ridge National Laboratory: Present status and future plans

    International Nuclear Information System (INIS)

    The Holifield Radioactive Ion Beam Facility (HRIBF) is a first generation national user facility for nuclear physics and nuclear astrophysics research with radioactive ion beams (RIBs). The reconfiguration, construction, and equipment commissioning phases have been completed and the beam development program is in progress. In this article, descriptions of the facility and newly implemented experimental equipment for use in the nuclear and astrophysics programs will be given and an outline of the initial experimental program will be presented. Special target ion source related problems, endemic to the production of specific short lived RIBs will be discussed. In addition, plans, which involve either a 200 MeV or a 1 GeV proton linac driver for a second generation ISOL facility, will be presented

  10. The Holifield Radioactive Ion Beam Facility at the Oak Ridge National Laboratory: Present status and future plans

    International Nuclear Information System (INIS)

    The Holifield Radioactive Ion Beam Facility (HRIBF) is a first generation national user facility for nuclear physics and nuclear astrophysics research with radioactive ion beams (RIBS). The reconfiguration, construction, and equipment-commissioning phases have been completed and the beam development program is in progress. In this article, descriptions of the facility and newly implemented experimental equipment for use in the nuclear and astrophysics programs will be given and an outline of the initial experimental program will be presented. Special target/ion source related problems, endemic to the production of specific short-lived RIBs will be discussed. In addition, plans, which involve either a 200-MeV or a 1-GeV proton-linac driver for a second-generation ISOL facility, will be presented

  11. CNGS, CERN Neutrinos to Gran Sasso, Five Years of Running a 500 Kilowatt Neutrino Beam Facility at CERN

    CERN Document Server

    Gschwendtner, E; Efthymiopoulos, I; Kratschmer, I; Pardons, A; Vincke, H; Wenninger, J

    2013-01-01

    The CNGS facility (CERN Neutrinos to Gran Sasso) aims at directly detecting muon to tau neutrino oscillations. An intense muon-neutrino beam (1017 muon-neutrinos/day) is generated at CERN and directed over 732 km towards the Gran Sasso National Laboratory, LNGS, in Italy, where two large and complex detectors, OPERA and ICARUS, are located. The CNGS facility started with the physics program in 2008 and delivered until the end of the physics run in 2012 more than 81% of the approved protons on target (22.5·1019 pot). An overview of the performance and experience gained in operating this 500 kW neutrino beam facility is described. Major events since the commissioning of the facility in 2006 are summarized. Highlights on the CNGS beam performance are given.

  12. SU-E-T-567: Neutron Dose Equivalent Evaluation for Pencil Beam Scanning Proton Therapy with Apertures

    International Nuclear Information System (INIS)

    Purpose: To determine the neutron contamination from the aperture in pencil beam scanning during proton therapy. Methods: A Monte Carlo based proton therapy research platform TOPAS and the UF-series hybrid pediatric phantoms were used to perform this study. First, pencil beam scanning (PBS) treatment pediatric plans with average spot size of 10 mm at iso-center were created and optimized for three patients with and without apertures. Then, the plans were imported into TOPAS. A scripting method was developed to automatically replace the patient CT with a whole body phantom positioned according to the original plan iso-center. The neutron dose equivalent was calculated using organ specific quality factors for two phantoms resembling a 4- and 14-years old patient. Results: The neutron dose equivalent generated by the apertures in PBS is 4–10% of the total neutron dose equivalent for organs near the target, while roughly 40% for organs far from the target. Compared to the neutron dose equivalent caused by PBS without aperture, the results show that the neutron dose equivalent with aperture is reduced in the organs near the target, and moderately increased for those organs located further from the target. This is due to the reduction of the proton dose around the edge of the CTV, which causes fewer neutrons generated in the patient. Conclusion: Clinically, for pediatric patients, one might consider adding an aperture to get a more conformal treatment plan if the spot size is too large. This work shows the somewhat surprising fact that adding an aperture for beam scanning for facilities with large spot sizes reduces instead of increases a potential neutron background in regions near target. Changran Geng is supported by the Chinese Scholarship Council (CSC) and the National Natural Science Foundation of China (Grant No. 11475087)

  13. GATE simulation based feasibility studies of in-beam PET monitoring in 12C beam cancer therapy

    Institute of Scientific and Technical Information of China (English)

    WU Jing; LIU Yaqiang; MA Tianyu; WEI Qingyang; WANG Shi; CHENG Jianping

    2010-01-01

    In comparison with conventional radiotherapy techniques,12C beam therapy has its significant advantage in cancer treatment because the radiation dose are mostly concentrated near the Bragg peak region and damage to normal tissues along the beam path is thus greatly reduced.In-beam PET provides a way to monitor dose distribution inside human body since several kinds of positron-emitting nuclei are produced through the interaction between 12C beam and body matters.In this work,we study the quantitative relationship between the spatial location of the Bragg peak and the spatial distribution of positrons produced by positron-emitting nuclei.Monte Carlo package GATE is used to simulate the interactions between the incident 12C beam of different energies (337.5,270.0 and 195.0 MeV/u) and various target matters (water,muscle and spine bone).Several data post-processing operations are performed on the simulated positron-emitting nuclei distribution data to mimic the impacts of positron generation and finite spatial resolution of a typical PET imaging system.Simulation results are compared to published experimental data for verification.In all the simulation cases,we fred that 10C and 11C are two dominant positron-emitting nuclei,and there exists a significant correlation between the spatial distributions of deposited energy and positrons.Therefore,we conclude that it is possible to determine the location of Bragg peak with 1 mm accuracy using current PET imaging systems by detecting the falling edge of the positron distribution map in depth direction.

  14. GATE simulation based feasibility studies of in-beam PET monitoring in 12C beam cancer therapy

    International Nuclear Information System (INIS)

    In comparison with conventional radiotherapy techniques, 12C beam therapy has its significant advantage in cancer treatment because the radiation dose are mostly concentrated near the Bragg peak region and damage to normal tissues along the beam path is thus greatly reduced. In-beam PET provides a way to monitor dose distribution inside human body since several kinds of positron-emitting nuclei are produced through the interaction between 12C beam and body matters. In this work, we study the quantitative relationship between the spatial location of the Bragg peak and the spatial distribution of positrons produced by positron-emitting nuclei. Monte Carlo package GATE is used to simulate the interactions between the incident 12C beam of different energies (337.5, 270.0 and 195.0 MeV/u) and various target matters (water, muscle and spine bone). Several data post-processing operations are performed on the simulated positron-emitting nuclei distribution data to mimic the impacts of positron generation and finite spatial resolution of a typical PET imaging system. Simulation results are compared to published experimental data for verification. In all the simulation cases, we find that 10C and 11C are two dominant positron-emitting nuclei, and there exists a significant correlation between the spatial distributions of deposited energy and positrons. Therefore, we conclude that it is possible to determine the location of Bragg peak with 1 mm accuracy using current PET imaging systems by detecting the falling edge of the positron distribution map in depth direction. (authors)

  15. Beam orientation optimization for intensity modulated radiation therapy using adaptive l2,1-minimization

    Science.gov (United States)

    Jia, Xun; Men, Chunhua; Lou, Yifei; Jiang, Steve B.

    2011-10-01

    Beam orientation optimization (BOO) is a key component in the process of intensity modulated radiation therapy treatment planning. It determines to what degree one can achieve a good treatment plan in the subsequent plan optimization process. In this paper, we have developed a BOO algorithm via adaptive l2, 1-minimization. Specifically, we introduce a sparsity objective function term into our model which contains weighting factors for each beam angle adaptively adjusted during the optimization process. Such an objective function favors a small number of beam angles. By optimizing a total objective function consisting of a dosimetric term and the sparsity term, we are able to identify unimportant beam angles and gradually remove them without largely sacrificing the dosimetric objective. In one typical prostate case, the convergence property of our algorithm, as well as how beam angles are selected during the optimization process, is demonstrated. Fluence map optimization (FMO) is then performed based on the optimized beam angles. The resulting plan quality is presented and is found to be better than that of equiangular beam orientations. We have further systematically validated our algorithm in the contexts of 5-9 coplanar beams for five prostate cases and one head and neck case. For each case, the final FMO objective function value is used to compare the optimized beam orientations with the equiangular ones. It is found that, in the majority of cases tested, our BOO algorithm leads to beam configurations which attain lower FMO objective function values than those of corresponding equiangular cases, indicating the effectiveness of our BOO algorithm. Superior plan qualities are also demonstrated by comparing DVH curves between BOO plans and equiangular plans.

  16. Pertinence analysis of intensity-modulated radiation therapy dosimetry error and parameters of beams

    International Nuclear Information System (INIS)

    Objective: To study the relationship between parameter settings in the intensity-modulated radiation therapy (IMRT) planning in order to explore the effect of parameters on absolute dose verification. Methods: Forty-three esophageal carcinoma cases were optimized with Pinnacle 7.6c by experienced physicist using appropriate optimization parameters and dose constraints with a number of iterations to meet the clinical acceptance criteria. The plans were copied to water-phantom, 0.13 cc ion Farmer chamber and DOSE1 dosimeter was used to measure the absolute dose. The statistical data of the parameters of beams for the 43 cases were collected, and the relationships among them were analyzed. The statistical data of the dosimetry error were collected, and comparative analysis was made for the relation between the parameters of beams and ion chamber absolute dose verification results. Results: The parameters of beams were correlated among each other. Obvious affiliation existed between the dose accuracy and parameter settings. When the beam segment number of IMRT plan was more than 80, the dose deviation would be greater than 3%; however, if the beam segment number was less than 80, the dose deviation was smaller than 3%. When the beam segment number was more than 100, part of the dose deviation of this plan was greater than 4%. On the contrary, if the beam segment number was less than 100, the dose deviation was smaller than 4% definitely. Conclusions: In order to decrease the absolute dose verification error, less beam angles and less beam segments are needed and the beam segment number should be controlled within the range of 80. (authors)

  17. High power transcranial beam steering for ultrasonic brain therapy

    International Nuclear Information System (INIS)

    A sparse phased array is specially designed for non-invasive ultrasound transskull brain therapy. The array is made of 200 single elements corresponding to a new generation of high power transducers developed in collaboration with Imasonic (Besancon, France). Each element has a surface of 0.5 cm2 and works at 0.9 MHz central frequency with a maximum 20 W cm-2 intensity on the transducer surface. In order to optimize the steering capabilities of the array, several transducer distributions on a spherical surface are simulated: hexagonal, annular and quasi-random distributions. Using a quasi-random distribution significantly reduces the grating lobes. Furthermore, the simulations show the capability of the quasi-random array to electronically move the focal spot in the vicinity of the geometrical focus (up to ±15 mm). Based on the simulation study, the array is constructed and tested. The skull aberrations are corrected by using a time reversal mirror with amplitude correction achieved thanks to an implantable hydrophone, and a sharp focus is obtained through a human skull. Several lesions are induced in fresh liver and brain samples through human skulls, demonstrating the accuracy and the steering capabilities of the system

  18. CT based treatment planning system of proton beam therapy for ocular melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Nakano, Takashi E-mail: tnakano@med.gunma-u.ac.jp; Kanai, Tatsuaki; Furukawa, Shigeo; Shibayama, Kouichi; Sato, Sinichiro; Hiraoka, Takeshi; Morita, Shinroku; Tsujii, Hirohiko

    2003-09-01

    A computed tomography (CT) based treatment planning system of proton beam therapy was established specially for ocular melanoma treatment. A technique of collimated proton beams with maximum energy of 70 MeV are applied for treatment for ocular melanoma. The vertical proton beam line has a range modulator for spreading beams out, a multi-leaf collimator, an aperture, light beam localizer, field light, and X-ray verification system. The treatment planning program includes; eye model, selecting the best direction of gaze, designing the shape of aperture, determining the proton range and range modulation necessary to encompass the target volume, and indicating the relative positions of the eyes, beam center and creation of beam aperture. Tumor contours are extracted from CT/MRI images of 1 mm thickness by assistant by various information of fundus photography and ultrasonography. The CT image-based treatment system for ocular melanoma is useful for Japanese patients as having thick choroid membrane in terms of dose sparing to skin and normal organs in the eye. The characteristics of the system and merits/demerits were reported.

  19. Treatment planning, optimization, and beam delivery technqiues for intensity modulated proton therapy

    Science.gov (United States)

    Sengbusch, Evan R.

    Physical properties of proton interactions in matter give them a theoretical advantage over photons in radiation therapy for cancer treatment, but they are seldom used relative to photons. The primary barriers to wider acceptance of proton therapy are the technical feasibility, size, and price of proton therapy systems. Several aspects of the proton therapy landscape are investigated, and new techniques for treatment planning, optimization, and beam delivery are presented. The results of these investigations suggest a means by which proton therapy can be delivered more efficiently, effectively, and to a much larger proportion of eligible patients. An analysis of the existing proton therapy market was performed. Personal interviews with over 30 radiation oncology leaders were conducted with regard to the current and future use of proton therapy. In addition, global proton therapy market projections are presented. The results of these investigations serve as motivation and guidance for the subsequent development of treatment system designs and treatment planning, optimization, and beam delivery methods. A major factor impacting the size and cost of proton treatment systems is the maximum energy of the accelerator. Historically, 250 MeV has been the accepted value, but there is minimal quantitative evidence in the literature that supports this standard. A retrospective study of 100 patients is presented that quantifies the maximum proton kinetic energy requirements for cancer treatment, and the impact of those results with regard to treatment system size, cost, and neutron production is discussed. This study is subsequently expanded to include 100 cranial stereotactic radiosurgery (SRS) patients, and the results are discussed in the context of a proposed dedicated proton SRS treatment system. Finally, novel proton therapy optimization and delivery techniques are presented. Algorithms are developed that optimize treatment plans over beam angle, spot size, spot spacing

  20. Beam specific planning target volumes incorporating 4DCT for pencil beam scanning proton therapy of thoracic tumors

    CERN Document Server

    Lin, Liyong; Huang, Sheng; Mayer, Rulon; Thomas, Andrew; Solberg, Timothy D; McDonough, James E; Simone, Charles B

    2015-01-01

    The purpose of this study is to determine whether organ sparing and target coverage can be simultaneously maintained for pencil beam scanning (PBS) proton therapy treatment of thoracic tumors in the presence of motion, stopping power uncertainties and patient setup variations. Ten consecutive patients that were previously treated with proton therapy to 66.6/1.8 Gy (RBE) using double scattering (DS) were replanned with PBS. Minimum and maximum intensity images from 4DCT were used to introduce flexible smearing in the determination of the beam specific PTV (BSPTV). Datasets from eight 4DCT phases, using +-3% uncertainty in stopping power, and +-3 mm uncertainty in patient setup in each direction were used to create 8X12X10=960 PBS plans for the evaluation of ten patients. Plans were normalized to provide identical coverage between DS and PBS. The average lung V20, V5, and mean doses were reduced from 29.0%, 35.0%, and 16.4 Gy with DS to 24.6%, 30.6%, and 14.1 Gy with PBS, respectively. The average heart V30 and...

  1. Status of neutron beam facilities at HANARO and a thermal neutron guide project of KAERI

    International Nuclear Information System (INIS)

    After successful installation of cold neutron facilities at HANARO such as neutron guides, cold neutron source including cold neutron instruments, now 14 cold and thermal neutron spectrometers are operating, and 5 instruments are under commissioning. The neutron guides with complicated shapes placed in the beam plug and the main shutter also in the curved part were delivered by a guide provider but the rest guides such as the guides in the guide bunker and the guide hall area were fabricated by KAERI. All the guides are coated with M=2 supermirror having different cross-sections and curvatures were operating with a high performance, where 10 cold neutron spectrometers will open to outside users. For a planning of a new project called ‘thermal guide facilities development’, the neutron guide system design started late last year, which was carried out to optimize the layout of the instruments and to calculate the neutron flux at sample position. At this meeting, the simulation results of the thermal neutron guide beam lines, status of in-house neutron guide development and specifications of some instruments will be presented.

  2. On-shot laser beam diagnostics for high-power laser facility with phase modulation imaging

    Science.gov (United States)

    Pan, X.; Veetil, S. P.; Liu, C.; Tao, H.; Jiang, Y.; Lin, Q.; Li, X.; Zhu, J.

    2016-05-01

    A coherent-modulation-imaging-based (CMI) algorithm has been employed for on-shot laser beam diagnostics in high-power laser facilities, where high-intensity short-pulsed lasers from terawatt to petawatt are designed to realize inertial confinement fusion (ICF). A single-shot intensity measurement is sufficient for wave-front reconstruction, both for the near-field and far-field at the same time. The iterative reconstruction process is computationally very efficient and was completed in dozens of seconds by the additional use of a GPU device to speed it up. The compact measurement unit—including a CCD and a piece of pre-characterized phase plate—makes it convenient for focal-spot intensity prediction in the target chamber. It can be placed almost anywhere in high-power laser facilities to achieve near-field wave-front diagnostics. The feasibility of the method has been demonstrated by conducting a series of experiments with diagnostic beams and seed pulses with deactivated amplifiers in our high-power laser system.

  3. IEEE 1394 CAMERA IMAGING SYSTEM FOR BROOKHAVENS BOOSTER APPLICATION FACILITY BEAM DIAGNOSTICS

    International Nuclear Information System (INIS)

    Brookhaven's Booster Applications Facility (BAF) will deliver resonant extracted heavy ion beams from the AGS Booster to short-exposure fixed-target experiments located at the end of the BAF beam line. The facility is designed to deliver a wide range of heavy ion species over a range of intensities from 103 to over 108 ions/pulse, and over a range of energies from 0.1 to 3.0 GeV/nucleon. With these constraints we have designed instrumentation packages which can deliver the maximum amount of dynamic range at a reasonable cost. Through the use of high quality optics systems and neutral density light filters we will achieve 4 to 5 orders of magnitude in light collection. By using digital IEEE1394 camera systems we are able to eliminate the frame-grabber stage in processing and directly transfer data at maximum rates of 400 Mb/set. In this note we give a detailed description of the system design and discuss the parameters used to develop the system specifications. We will also discuss the IEEE1394 camera software interface and the high-level user interface

  4. A facility for studying radiative capture reactions induced with radioactive beams at ISAC

    Science.gov (United States)

    D'Auria, J. M.; Buchmann, L.; Hutcheon, D.; Lipnik, P.; Hunter, D.; Rogers, J.; Helmer, R.; Giesen, U.; Olin, A.; Bricault, P.; Bateman, N.

    The measurement of low energy fusion reactions of importance to nuclear astrophysics scenarios are a prime objective of the physics program of the new ISAC facility, located at TRIUMF in Vancouver, Canada. Intense radioactive beams of 19Ne, 14,15O, 20,21Na, 17,18F and other low Z species with energies in the range of 0.15 to 1.5 MeV/mass unit will be available to measure cross sections and resonance strengths of alpha and proton induced reactions. An important component of the experimental configuration will be a new Recoil Product Detection Facility (RPDF) consisting of a windowless gas target, surrounded by a gamma array, while the recoils are separated from the intense radioactive beam using a Electro-Magnetic Separator (EMS) employing Wien filters. The recoiling reaction products will then be detected using either a Si μ-strip array or a gas filled detector. Using these devices along with coincidence requirements and time-of-flight conditions a background reduction factor of the order of 10 +15 is the present goal.

  5. The development of BATAN's neutron beam facilities and their applications

    International Nuclear Information System (INIS)

    Neutron scattering laboratory is one of the facilities utilizing neutron beam produced by the RSGGAS reactor at Serpong for materials R&D. The laboratory is equipped with seven neutron beam instruments, i.e: Diffractometer for Residual Stress Measurement (DN1), Four Circle/Texture Diffractometer (DN2), High Resolution Powder Diffractometer (DN3), Triple Axis Spectrometer (SN1), Small Angle Neutron Scattering Spectrometer (DN2), High Resolution Small Angle Neutron Scattering Spectrometer (SN3) and Radiography Facility (RN1). The instruments have been developed to meet the requirement demanded by the users to reach their research objectives such as the replacement of some detectors in neutron diffractometer from point detector to 2D detector, the refurbishing of the 2D-Position Sensitive Detector in SANS machine and the use of neutron tomography to replace the old neutron radiography film technique. The upgraded instruments have been used to perform research and development in various topics such as materials for battery, magnetic materials and automotive industry. The current status of the instruments and their development as well as their applications for research on advanced materials and industry are presented.

  6. The Utility of Proton Beam Therapy with Concurrent Chemotherapy for the Treatment of Esophageal Cancers

    Directory of Open Access Journals (Sweden)

    Steven H. Lin

    2011-10-01

    Full Text Available The standard of care for the management of locally advanced esophageal cancers in the United States is chemotherapy combined with radiation, either definitively, or for those who could tolerate surgery, preoperatively before esophagectomy. Although the appropriate radiation dose remains somewhat controversial, the quality of the radiation delivery is critical for the treatment of esophageal cancer since the esophagus is positioned close to vital structures, such as the heart and lung. The volume and relative doses to these normal tissues affect acute and late term complications. Advances in radiation delivery from 2D to 3D conformal radiation therapy, to Intensity Modulated Radiation Therapy (IMRT or charged particle therapy (carbon ion or proton beam therapy (PBT, allow incremental improvements in the therapeutic ratio. This could have implications in non-cancer related morbidity for long term survivors. This article reviews the evolution in radiation technologies and the use of PBT with chemotherapy in the management of esophageal cancer.

  7. The Utility of Proton Beam Therapy with Concurrent Chemotherapy for the Treatment of Esophageal Cancers

    International Nuclear Information System (INIS)

    The standard of care for the management of locally advanced esophageal cancers in the United States is chemotherapy combined with radiation, either definitively, or for those who could tolerate surgery, preoperatively before esophagectomy. Although the appropriate radiation dose remains somewhat controversial, the quality of the radiation delivery is critical for the treatment of esophageal cancer since the esophagus is positioned close to vital structures, such as the heart and lung. The volume and relative doses to these normal tissues affect acute and late term complications. Advances in radiation delivery from 2D to 3D conformal radiation therapy, to Intensity Modulated Radiation Therapy (IMRT) or charged particle therapy (carbon ion or proton beam therapy (PBT)), allow incremental improvements in the therapeutic ratio. This could have implications in non-cancer related morbidity for long term survivors. This article reviews the evolution in radiation technologies and the use of PBT with chemotherapy in the management of esophageal cancer

  8. Neutron transport study of a beam port based dynamic neutron radiography facility

    Science.gov (United States)

    Khaial, Anas M.

    Neutron radiography has the ability to differentiate between gas and liquid in two-phase flow due both to the density difference and the high neutron scattering probability of hydrogen. Previous studies have used dynamic neutron radiography -- in both real-time and high-speed -- for air-water, steam-water and gas-liquid metal two-phase flow measurements. Radiography with thermal neutrons is straightforward and efficient as thermal neutrons are easier to detect with relatively higher efficiency and can be easily extracted from nuclear reactor beam ports. The quality of images obtained using neutron radiography and the imaging speed depend on the neutron beam intensity at the imaging plane. A high quality neutron beam, with thermal neutron intensity greater than 3.0x 10 6 n/cm2-s and a collimation ratio greater than 100 at the imaging plane, is required for effective dynamic neutron radiography up to 2000 frames per second. The primary objectives of this work are: (1) to optimize a neutron radiography facility for dynamic neutron radiography applications and (2) to investigate a new technique for three-dimensional neutron radiography using information obtained from neutron scattering. In this work, neutron transport analysis and experimental validation of a dynamic neutron radiography facility is studied with consideration of real-time and high-speed neutron radiography requirements. A beam port based dynamic neutron radiography facility, for a target thermal neutron flux of 1.0x107 n/cm2-s, has been analyzed, constructed and experimentally verified at the McMaster Nuclear Reactor. The neutron source strength at the beam tube entrance is evaluated experimentally by measuring the thermal and fast neutron fluxes using copper activation flux-mapping technique. The development of different facility components, such as beam tube liner, gamma ray filter, beam shutter and biological shield, is achieved analytically using neutron attenuation and divergence theories. Monte

  9. Determination of homogeneity of heavy ion beam and a simulation test of beam shaping for cancer therapy

    International Nuclear Information System (INIS)

    The homogeneity of 25 MeV/u 40Ar14+ ion beam (φ40 mm) was measured with 50 μm polycarbonate films by means of nuclear track detection. It was 32.7% for the case of defocus and 52.4% for 'defocus + sample rotation'. A simulation test of beam shaping for heavy-ion cancer therapy was carried out with an assembly of multilayer polycarbonate films as the tumour equivalent material. The Bragg-peak was moved at nine locations through energy degradation of the heavy ions. The beam cross sections at each Bragg-peak location were defined by different apertures. Thus, an ellipsoid like tumour was formed from the cross-sections of different layers. A light-ball similar to the ellipsoid tumour was obtained by means of transmission and diffraction of a light column passing through ion track pores in the irradiated polycarbonate films after chemical etching. The sphere of the light-ball corresponded to the space effected by Bragg-peaks where the energy loss of heavy ions was concentrated

  10. Early hot electrons generation and beaming in ICF gas filled hohlraums at the National Ignition Facility

    Science.gov (United States)

    Dewald, Eduard; Michel, Pierre; Hartemann, Fred; Milovich, Jose; Hohenberger, Matthias; Divol, Laurent; Landen, Otto; Pak, Arthur; Thomas, Cliff; Doeppner, Tilo; Bachmann, Benjamin; Meezan, Nathan; MacKinnon, Andrew; Hurricane, Omar; Callahan, Debbie; Hinkel, Denise; Edwards, John

    2015-11-01

    In laser driven hohlraum capsule implosions on the National Ignition Facility, supra-thermal hot electrons generated by laser plasma instabilities can preheat the capsule. Time resolved hot electron Bremsstrahlung spectra combined with 30 keV x-ray imaging uncover for the first time the directionality of hot electrons onto a high-Z surrogate capsule located at the hohlraum center. In the most extreme case, we observed a collimated beaming of hot electrons onto the capsule poles, reaching 50x higher localized energy deposition than for isotropic electrons. A collective SRS model where all laser beams in a cone drive a common plasma wave provides a physical interpretation for the observed beaming. Imaging data are used to distinguish between this mechanism and 2ωp instability. The amount of hot electrons generated can be controlled by the laser pulse shape and hohlraum plasma conditions. This work performed under the auspices of the U.S. DOE by LLNL under Contract DE-AC52-07NA27344.

  11. Development of a prompt gamma activation analysis facility using diffracted polychromatic neutron beam

    CERN Document Server

    Byun, S H; Choi, H D

    2002-01-01

    A prompt gamma activation analysis facility has recently been developed at Hanaro, the 24 MW research reactor in the Korea Atomic Energy Research Institute. Polychromatic thermal neutrons are extracted by setting pyrolytic graphite crystals at a Bragg angle of 45 deg. . The detection system comprises a large single n-type HPGe detector, signal electronics and a fast ADC. Neutron beam characterization was performed both theoretically and experimentally. The neutron flux was measured to be 7.9x10 sup 7 n/cm sup 2 s in a 1x1 cm sup 2 beam area at the sample position with a uniformity of 12%. The corresponding Cd-ratio for gold was found to be 266. The beam quality was compared with other representative thermal neutron prompt gamma activation analysis. The detection efficiency was calibrated up to 11 MeV using a set of radionuclides and the (n,gamma) reactions of N and Cl. Finally, the sensitivities and the detection limits were obtained for several elements.

  12. Development of a prompt gamma activation analysis facility using diffracted polychromatic neutron beam

    International Nuclear Information System (INIS)

    A prompt gamma activation analysis facility has recently been developed at Hanaro, the 24 MW research reactor in the Korea Atomic Energy Research Institute. Polychromatic thermal neutrons are extracted by setting pyrolytic graphite crystals at a Bragg angle of 45 deg. . The detection system comprises a large single n-type HPGe detector, signal electronics and a fast ADC. Neutron beam characterization was performed both theoretically and experimentally. The neutron flux was measured to be 7.9x107 n/cm2 s in a 1x1 cm2 beam area at the sample position with a uniformity of 12%. The corresponding Cd-ratio for gold was found to be 266. The beam quality was compared with other representative thermal neutron prompt gamma activation analysis. The detection efficiency was calibrated up to 11 MeV using a set of radionuclides and the (n,γ) reactions of N and Cl. Finally, the sensitivities and the detection limits were obtained for several elements

  13. Targets for ion sources for RIB generation at the Holifield Radioactive Ion Beam Facility

    International Nuclear Information System (INIS)

    The Holifield Radioactive Ion Beam Facility (HRIBF), now under construction at the Oak Ridge National Laboratory, is based on the use of the well-known on-line isotope separator (ISOL) technique in which radioactive nuclei are produced by fusion type reactions in selectively chosen target materials by high-energy proton, deuteron, or He ion beams from the Oak Ridge Isochronous Cyclotron (ORIC). Among several major challenges posed by generating and accelerating adequate intensities of radioactive ion beams (RIBs), selection of the most appropriate target material for production of the species of interest is, perhaps, the most difficult. In this report, we briefly review present efforts to select target materials and to design composite target matrix/heat-sink systems that simultaneously incorporate the short diffusion lengths, high permeabilities, and controllable temperatures required to effect maximum diffusion release rates of the short-lived species that can be realized at the temperature limits of specific target materials. We also describe the performance characteristics for a selected number of target ion sources that will be employed for initial use at the HRIBF as well as prototype ion sources that show promise for future use for RIB applications

  14. Development of a prompt gamma activation analysis facility using diffracted polychromatic neutron beam

    Science.gov (United States)

    Byun, S. H.; Sun, G. M.; Choi, H. D.

    2002-07-01

    A prompt gamma activation analysis facility has recently been developed at Hanaro, the 24 MW research reactor in the Korea Atomic Energy Research Institute. Polychromatic thermal neutrons are extracted by setting pyrolytic graphite crystals at a Bragg angle of 45°. The detection system comprises a large single n-type HPGe detector, signal electronics and a fast ADC. Neutron beam characterization was performed both theoretically and experimentally. The neutron flux was measured to be 7.9×10 7 n/cm 2 s in a 1×1 cm 2 beam area at the sample position with a uniformity of 12%. The corresponding Cd-ratio for gold was found to be 266. The beam quality was compared with other representative thermal neutron prompt gamma activation analysis. The detection efficiency was calibrated up to 11 MeV using a set of radionuclides and the (n,γ) reactions of N and Cl. Finally, the sensitivities and the detection limits were obtained for several elements.

  15. Integration and evaluation of automated Monte Carlo simulations in the clinical practice of scanned proton and carbon ion beam therapy

    International Nuclear Information System (INIS)

    Monte Carlo (MC) simulations of beam interaction and transport in matter are increasingly considered as essential tools to support several aspects of radiation therapy. Despite the vast application of MC to photon therapy and scattered proton therapy, clinical experience in scanned ion beam therapy is still scarce. This is especially the case for ions heavier than protons, which pose additional issues like nuclear fragmentation and varying biological effectiveness. In this work, we present the evaluation of a dedicated framework which has been developed at the Heidelberg Ion Beam Therapy Center to provide automated FLUKA MC simulations of clinical patient treatments with scanned proton and carbon ion beams. Investigations on the number of transported primaries and the dimension of the geometry and scoring grids have been performed for a representative class of patient cases in order to provide recommendations on the simulation settings, showing that recommendations derived from the experience in proton therapy cannot be directly translated to the case of carbon ion beams. The MC results with the optimized settings have been compared to the calculations of the analytical treatment planning system (TPS), showing that regardless of the consistency of the two systems (in terms of beam model in water and range calculation in different materials) relevant differences can be found in dosimetric quantities and range, especially in the case of heterogeneous and deep seated treatment sites depending on the ion beam species and energies, homogeneity of the traversed tissue and size of the treated volume. The analysis of typical TPS speed-up approximations highlighted effects which deserve accurate treatment, in contrast to adequate beam model simplifications for scanned ion beam therapy. In terms of biological dose calculations, the investigation of the mixed field components in realistic anatomical situations confirmed the findings of previous groups so far reported only in

  16. The feasibility and safety of high-intensity focused ultrasound combined with low-dose external beam radiotherapy as supplemental therapy for advanced prostate cancer following hormonal therapy

    OpenAIRE

    Wu, Rui-Yi; Wang, Guo-Min; Xu, Lei; ZHANG, BO-HENG; Xu, Ye-Qing; Zeng, Zhao-Chong; Chen, Bing

    2011-01-01

    The aim of this study was to investigate the feasibility and safety of high-intensity focused ultrasound (HIFU) combined with (+) low-dose external beam radiotherapy (LRT) as supplemental therapy for advanced prostate cancer (PCa) following hormonal therapy (HT). Our definition of HIFU+LRT refers to treating primary tumour lesions with HIFU in place of reduced field boost irradiation to the prostate, while retaining four-field box irradiation to the pelvis in conventional-dose external beam r...

  17. Design and application of 3D-printed stepless beam modulators in proton therapy.

    Science.gov (United States)

    Lindsay, C; Kumlin, J; Martinez, D M; Jirasek, A; Hoehr, C

    2016-06-01

    A new method for the design of stepless beam modulators for proton therapy is described and verified. Simulations of the classic designs are compared against the stepless method for various modulation widths which are clinically applicable in proton eye therapy. Three modulator wheels were printed using a Stratasys Objet30 3D printer. The resulting depth dose distributions showed improved uniformity over the classic stepped designs. Simulated results imply a possible improvement in distal penumbra width; however, more accurate measurements are needed to fully verify this effect. Lastly, simulations were done to model bio-equivalence to Co-60 cell kill. A wheel was successfully designed to flatten this metric. PMID:27182839

  18. Low-dose (10-Gy) total skin electron beam therapy for cutaneous T-cell lymphoma

    DEFF Research Database (Denmark)

    Kamstrup, Maria R; zbr735, zbr735; Iversen, Lars;

    2015-01-01

    PURPOSE: Cutaneous T-cell lymphomas (CTCLs) are dominated by mycosis fungoides (MF) and Sézary syndrome (SS), and durable disease control is a therapeutic challenge. Standard total skin electron beam therapy (TSEBT) is an effective skin-directed therapy, but the possibility of retreatments is...... response or a very good partial response rate (<1% skin involvement with patches or plaques) documented in 57% of the patients. Median duration of overall cutaneous response was 174 days (5.8 months; range: 60-675 days). TSEBT-related acute adverse events (grade 1 or 2) were observed in 60% of patients...

  19. Design and application of 3D-printed stepless beam modulators in proton therapy

    Science.gov (United States)

    Lindsay, C.; Kumlin, J.; Martinez, D. M.; Jirasek, A.; Hoehr, C.

    2016-06-01

    A new method for the design of stepless beam modulators for proton therapy is described and verified. Simulations of the classic designs are compared against the stepless method for various modulation widths which are clinically applicable in proton eye therapy. Three modulator wheels were printed using a Stratasys Objet30 3D printer. The resulting depth dose distributions showed improved uniformity over the classic stepped designs. Simulated results imply a possible improvement in distal penumbra width; however, more accurate measurements are needed to fully verify this effect. Lastly, simulations were done to model bio-equivalence to Co-60 cell kill. A wheel was successfully designed to flatten this metric.

  20. External-beam radiation therapy after surgical resection and intraoperative electron-beam radiation therapy for oligorecurrent gynecological cancer. Long-term outcome

    Energy Technology Data Exchange (ETDEWEB)

    Sole, C.V. [Hospital General Universitario Gregorio Maranon, Department of Oncology, Madrid (Spain); Complutense University, School of Medicine, Madrid (Spain); Instituto de Radiomedicina, Service of Radiation Oncology, Santiago (Chile); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Calvo, F.A. [Hospital General Universitario Gregorio Maranon, Department of Oncology, Madrid (Spain); Complutense University, School of Medicine, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Lozano, M.A.; Gonzalez-Sansegundo, C. [Hospital General Universitario Gregorio Maranon, Department of Oncology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Service of Radiation Oncology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Gonzalez-Bayon, L. [Hospital General Universitario Gregorio Maranon, Service of General Surgery, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Alvarez, A. [Hospital General Universitario Gregorio Maranon, Service of Radiation Oncology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Lizarraga, S. [Hospital General Universitario Gregorio Maranon, Department of Gynecology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Garcia-Sabrido, J.L. [Complutense University, School of Medicine, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Service of General Surgery, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Department of Gynecology, Madrid (Spain)

    2014-02-15

    The goal of the present study was to analyze prognostic factors in patients treated with external-beam radiation therapy (EBRT), surgical resection and intraoperative electron-beam radiotherapy (IOERT) for oligorecurrent gynecological cancer (ORGC). From January 1995 to December 2012, 61 patients with ORGC [uterine cervix (52 %), endometrial (30 %), ovarian (15 %), vagina (3 %)] underwent IOERT (12.5 Gy, range 10-15 Gy), and surgical resection to the pelvic (57 %) and paraaortic (43 %) recurrence tumor bed. In addition, 29 patients (48 %) also received EBRT (range 30.6-50.4 Gy). Survival outcomes were estimated using the Kaplan-Meier method, and risk factors were identified by univariate and multivariate analyses. Median follow-up time for the entire cohort of patients was 42 months (range 2-169 months). The 10-year rates for overall survival (OS) and locoregional control (LRC) were 17 and 65 %, respectively. On multivariate analysis, no tumor fragmentation (HR 0.22; p = 0.03), time interval from primary tumor diagnosis to locoregional recurrence (LRR) < 24 months (HR 4.02; p = 0.02) and no EBRT at the time of pelvic recurrence (HR 3.95; p = 0.02) retained significance with regard to LRR. Time interval from primary tumor to LRR < 24 months (HR 2.32; p = 0.02) and no EBRT at the time of pelvic recurrence (HR 3.77; p = 0.04) showed a significant association with OS after adjustment for other covariates. External-beam radiation therapy at the time of pelvic recurrence, time interval for relapse ≥24 months and not multi-involved fragmented resection specimens are associated with improved LRC in patients with ORGC. As suggested from the present analysis a significant group of ORGC patients could potentially benefit from multimodality rescue treatment. (orig.)

  1. External-beam radiation therapy after surgical resection and intraoperative electron-beam radiation therapy for oligorecurrent gynecological cancer. Long-term outcome

    International Nuclear Information System (INIS)

    The goal of the present study was to analyze prognostic factors in patients treated with external-beam radiation therapy (EBRT), surgical resection and intraoperative electron-beam radiotherapy (IOERT) for oligorecurrent gynecological cancer (ORGC). From January 1995 to December 2012, 61 patients with ORGC [uterine cervix (52 %), endometrial (30 %), ovarian (15 %), vagina (3 %)] underwent IOERT (12.5 Gy, range 10-15 Gy), and surgical resection to the pelvic (57 %) and paraaortic (43 %) recurrence tumor bed. In addition, 29 patients (48 %) also received EBRT (range 30.6-50.4 Gy). Survival outcomes were estimated using the Kaplan-Meier method, and risk factors were identified by univariate and multivariate analyses. Median follow-up time for the entire cohort of patients was 42 months (range 2-169 months). The 10-year rates for overall survival (OS) and locoregional control (LRC) were 17 and 65 %, respectively. On multivariate analysis, no tumor fragmentation (HR 0.22; p = 0.03), time interval from primary tumor diagnosis to locoregional recurrence (LRR) < 24 months (HR 4.02; p = 0.02) and no EBRT at the time of pelvic recurrence (HR 3.95; p = 0.02) retained significance with regard to LRR. Time interval from primary tumor to LRR < 24 months (HR 2.32; p = 0.02) and no EBRT at the time of pelvic recurrence (HR 3.77; p = 0.04) showed a significant association with OS after adjustment for other covariates. External-beam radiation therapy at the time of pelvic recurrence, time interval for relapse ≥24 months and not multi-involved fragmented resection specimens are associated with improved LRC in patients with ORGC. As suggested from the present analysis a significant group of ORGC patients could potentially benefit from multimodality rescue treatment. (orig.)

  2. Total body superficial electron beam therapy using a dual field technique

    International Nuclear Information System (INIS)

    A technique using a dual field is presented. This technique has applications in mycosis fungoides using superficial electron-beam with 8 MeV therapy. For the multiple-field irradiation with dual field technique, a six distribution setup is used with 8 MeV electron-beam disperes around the whole body surface 1 cm in depth for treatment of mycosis fungoides. Some of the physical aspects, dosimetory, loss of build-up, depth-dose shift and increasing braking radiation (bremsstrahlung) using multiple overlapping because of high energy for superficial whole-body irradiation therapy were discussed. The 6-field technique is the methods of choice for superficial whole-body treatment. (author)

  3. First tests for an online treatment monitoring system with in-beam PET for proton therapy

    CERN Document Server

    Kraan, Aafke C; Belcari, N; Camarlinghi, N; Cappucci, F; Ciocca, M; Ferrari, A; Ferretti, S; Mairani, A; Molinelli, S; Pullia, M; Retico, A; Sala, P; Sportelli, G; Del Guerra, A; Rosso, V

    2014-01-01

    PET imaging is a non-invasive technique for particle range verification in proton therapy. It is based on measuring the beta+ annihilations caused by nuclear interactions of the protons in the patient. In this work we present measurements for proton range verification in phantoms, performed at the CNAO particle therapy treatment center in Pavia, Italy, with our 10 x 10 cm^2 planar PET prototype DoPET. PMMA phantoms were irradiated with mono-energetic proton beams and clinical treatment plans, and PET data were acquired during and shortly after proton irradiation. We created 1-D profiles of the beta+ activity along the proton beam-axis, and evaluated the difference between the proximal rise and the distal fall-off position of the activity distribution. A good agreement with FLUKA Monte Carlo predictions was obtained. We also assessed the system response when the PMMA phantom contained an air cavity. The system was able to detect these cavities quickly after irradiation.

  4. Particle in cell simulation of laser-accelerated proton beams for radiation therapy

    International Nuclear Information System (INIS)

    In this article we present the results of particle in cell (PIC) simulations of laser plasma interaction for proton acceleration for radiation therapy treatments. We show that under optimal interaction conditions protons can be accelerated up to relativistic energies of 300 MeV by a petawatt laser field. The proton acceleration is due to the dragging Coulomb force arising from charge separation induced by the ponderomotive pressure (light pressure) of high-intensity laser. The proton energy and phase space distribution functions obtained from the PIC simulations are used in the calculations of dose distributions using the GEANT Monte Carlo simulation code. Because of the broad energy and angular spectra of the protons, a compact particle selection and beam collimation system will be needed to generate small beams of polyenergetic protons for intensity modulated proton therapy

  5. Feasibility study of glass dosimeter for postal dose intercomparison of high-energy proton therapy beams

    International Nuclear Information System (INIS)

    Purpose: We evaluated the glass dosimeter suitability as an external audit program in proton therapy beam. A feasibility test of the glass dosimeter postal dose intercomparison was performed for high-energy proton beam use in radiation oncology with the collaboration of five proton therapy centers (Shizuoka Cancer Center, University of Florida Proton Center, MD Anderson Cancer Center, Loma Linda University Medical Center, and University of Pennsylvania School of Medicine). Material and methods: The dosimetric properties of a GD-301 glass dosimeter were investigated for its potential use for postal dosimetry. Measurements were performed in a water phantom using a stair-like holder specially designed for this study. The depth-dose distribution measured with the glass dosimeter was compared to those from GEANT4 Monte-Carlo simulation. The GEANT4 code was also used to simulate the influence of holder material in the absorbed dose by inserting the glass dosimeter in a water phantom within the stair-like holder. We investigated the methodology of the absorbed dose determination with the glass dosimeter system establishing the calibration factor and various correction factors (non-linearity, fading, energy, holder). The participating proton therapy centers were asked to irradiate the glass dosimeter to 2 Gy with similar setup and conditions. Results: The repeatability and dose rate dependence is within 1.2% and 1.5%, respectively. Depth-dose distributions in the pristine Bragg curve and the spread-out Bragg curve were estimated to be within 3%, compared with depth-dose measured with the ionization chamber. The difference in absorbed dose between the glass dosimeter and ionization chamber was within ±2% as a function of proton beam quality, residual ranges were between 2.1 and 9.0 cm. The influence of the holder material in absorbed doses of the proton beams is less than 1%. In the accuracy evaluation of the glass dosimeter system established in blind test, we obtained

  6. Proton beam therapy and localised prostate cancer: current status and controversies

    OpenAIRE

    Efstathiou, J. A.; Gray, P. J.; Zietman, A L

    2013-01-01

    Proton therapy is a promising, but costly, treatment for prostate cancer. Theoretical physical advantages exist; yet to date, it has been shown only to be comparably safe and effective when compared with the alternatives and not necessarily superior. If clinically meaningful benefits do exist for patients, more rigorous study will be needed to detect them and society will require this to justify the investment of time and money. New technical advances in proton beam delivery coupled with shor...

  7. Laser-Driven Very High Energy Electron/Photon Beam Radiation Therapy in Conjunction with a Robotic System

    Directory of Open Access Journals (Sweden)

    Kazuhisa Nakajima

    2014-12-01

    Full Text Available We present a new external-beam radiation therapy system using very-high-energy (VHE electron/photon beams generated by a centimeter-scale laser plasma accelerator built in a robotic system. Most types of external-beam radiation therapy are delivered using a machine called a medical linear accelerator driven by radio frequency (RF power amplifiers, producing electron beams with an energy range of 6–20 MeV, in conjunction with modern radiation therapy technologies for effective shaping of three-dimensional dose distributions and spatially accurate dose delivery with imaging verification. However, the limited penetration depth and low quality of the transverse penumbra at such electron beams delivered from the present RF linear accelerators prevent the implementation of advanced modalities in current cancer treatments. These drawbacks can be overcome if the electron energy is increased to above 50 MeV. To overcome the disadvantages of the present RF-based medical accelerators, harnessing recent advancement of laser-driven plasma accelerators capable of producing 1-GeV electron beams in a 1-cm gas cell, we propose a new embodiment of the external-beam radiation therapy robotic system delivering very high-energy electron/photon beams with an energy of 50–250 MeV; it is more compact, less expensive, and has a simpler operation and higher performance in comparison with the current radiation therapy system.

  8. The primary attenuation coefficient of a p(66)+Be(40) neutron therapy beam

    International Nuclear Information System (INIS)

    The concept of primary and scattered dose components of a radiotherapy beam is commonly used in radiotherapy planning. Four different methods which have been used for photon beams were applied to determine the primary dose linear attenuation coefficient in water (μo) in a p(66)+Be(40) neutron therapy beam. They were: (a) the extrapolation of measured tissue-maximum ratios to zero field size, (b) linear attenuation measurements, (c) dose measurements in phantom with and without a central axis attenuator, and (d) fitting a central axis kerma model, based on convolution techniques, to measured percentage depth dose data. The μo values obtained agree well with each other and vary between 0.071 cm-1 and 0.075 cm-1. (author)

  9. Proton Beam Therapy for Hepatocellular Carcinoma Located Adjacent to the Alimentary Tract

    International Nuclear Information System (INIS)

    Purpose: To evaluate the safety and effectiveness of proton beam therapy for hepatocellular carcinoma (HCC) located adjacent to the alimentary tract. Patients and Methods: Forty-seven patients (median age, 69 years; range, 43-82 years) who had HCC located within 2 cm of the alimentary tract underwent proton beam therapy. Liver damage according to the Child-Pugh classification was Class A in 35 patients, Class B in 9, and Class C in 3. Treatment protocols of the early 16 patients and the late 31 patients were 72.6 GyE in 22 fractions and 77 GyE in 35 fractions, respectively. Results: During the median follow-up period of 23 months, 24 patients died; the remaining 23 patients were alive until September 2008. The median overall survival was 33.9 months (95% confidence interval [CI], 10.8-57.0 months). Actuarial overall and local progression-free survival rates at 3 years were 50.0% and 88.1%, respectively. Grade 2 and 3 alimentary tract hemorrhage was observed in 3 (6.4%) and 1 (2.1%) patients, respectively. Conclusions: Our proton beam therapy strategy for HCC located adjacent to the alimentary tract seems to be effective but should be performed with caution.

  10. A Prospective Study of Hypofractionated Proton Beam Therapy for Patients With Hepatocellular Carcinoma

    International Nuclear Information System (INIS)

    Purpose: To evaluate the efficacy and safety of hypofractionated proton beam therapy for patients with hepatocellular carcinoma (HCC). Methods and Materials: Between September 2001 and August 2004, 51 patients with HCC greater than 2 cm away from the porta hepatis or gastrointestinal tract were treated with proton beam therapy to 66 Gy-equivalents (GyE) in 10 fractions. Results: Overall survival rates were 49.2 and 38.7% at 3 and 5 years after treatment. Local control rates were 94.5 and 87.8% at 3 and 5 years after treatment. Posttreatment serum α-fetoprotein values were significantly reduced when compared with pretreatment values (p < 0.0001). Patients experienced only minor acute reactions of Grade 1 or less, and 3 patients experienced late sequelae of Grade 2 or higher. However, there were no treatment-related deaths. Conclusions: Hypofractionated proton beam therapy is safe and well-tolerated by patients with HCC located greater than 2 cm away from the porta hepatis or gastrointestinal tract and may be effective alternative to other modalities.

  11. The boron neutron capture therapy facility of the ETRR-2: a promising opportunity for cancer research and treatment

    International Nuclear Information System (INIS)

    Boron neutron capture therapy (BNCT) is a binary modality that can selectively irradiate tumor tissue using drugs containing 10B that are capable of preferntially accumulating in the tumor, which is then irradiated with thermal neutrins. This casuses the 10B nucleus to split, releasing an alpha particle and a lithium nucleus. These products are very damaging to cells but have ranges of the order of cell diameters. The technique is minly used for the treatment of Glioblastoma, a highly malignant tumor whose treatment is not statisfactory using conventional techniques. Other types of cancer, like melanoma, are also considered. Since early nineties, the area of BNCT is witnessing active developments in the USA, Japan, and Europe. the Egyptian second experimental and training research reactor (ETRR-2) is a pool-type MPR. It has four neutron beam and a thermal column as the main experimental devices. One of the main reactor facilities is the BNCT unit. The paper highlights the basics of the BNCT, its development, and status around the world. A brief description of the reactor, the BNCt uint as well as the preliminary analysis done for the facility is presented. The BNCT offers a unique opportunity for coordinated efforts by the arab nuclear organizations and medical institutions similar to the on going efforts at Petten, the netherlands

  12. Development of an optimization concept for arc-modulated cone beam therapy

    International Nuclear Information System (INIS)

    In this paper, we propose an optimization concept for a rotation therapy technique which is referred to as arc-modulated cone beam therapy (AMCBT). The aim is a reduction of the treatment time while achieving a treatment plan quality equal to or better than that of IMRT. Therefore, the complete dose is delivered in one single gantry rotation and the beam is modulated by a multileaf collimator. The degrees of freedom are the field shapes and weights for a predefined number of beam directions. In the new optimization loop, the beam weights are determined by a gradient algorithm and the field shapes by a tabu search algorithm. We present treatment plans for AMCBT for two clinical cases. In comparison to step-and-shoot IMRT treatment plans, it was possible by AMCBT to achieve dose distributions with a better dose conformity to the target and a lower mean dose for the most relevant organ at risk. Furthermore, the number of applied monitor units was reduced for AMCBT in comparison to IMRT treatment plans

  13. Development of an optimization concept for arc-modulated cone beam therapy.

    Science.gov (United States)

    Ulrich, Silke; Nill, Simeon; Oelfke, Uwe

    2007-07-21

    In this paper, we propose an optimization concept for a rotation therapy technique which is referred to as arc-modulated cone beam therapy (AMCBT). The aim is a reduction of the treatment time while achieving a treatment plan quality equal to or better than that of IMRT. Therefore, the complete dose is delivered in one single gantry rotation and the beam is modulated by a multileaf collimator. The degrees of freedom are the field shapes and weights for a predefined number of beam directions. In the new optimization loop, the beam weights are determined by a gradient algorithm and the field shapes by a tabu search algorithm. We present treatment plans for AMCBT for two clinical cases. In comparison to step-and-shoot IMRT treatment plans, it was possible by AMCBT to achieve dose distributions with a better dose conformity to the target and a lower mean dose for the most relevant organ at risk. Furthermore, the number of applied monitor units was reduced for AMCBT in comparison to IMRT treatment plans. PMID:17664597

  14. A beam intensity monitor for the Loma Linda cancer therapy proton accelerator

    International Nuclear Information System (INIS)

    A beam intensity monitor was tested in a 230-MeV proton beam at the Loma Linda Proton Therapy Accelerator during its commissioning at Fermi National Accelerator Laboratory. The intensity monitor was designed to regulate the beam intensity extracted from the proton synchrotron. The proton beam is tunable between 70 and 250 MeV with an adjustable intensity between 1010 and 1011 protons per spill. A beam spill is typically 1 s long with a 2-s repetition period. The intensity monitor must be radiation hard, expose minimum mass to the beam, and measure intensity to 1% in 1-ms time intervals. To this end, a 5-cm-thick xenon gas scintillator optically coupled to a photomultiplier tube (PMT) was tested to measure its response to the proton beam. The gas cell was operated at 1.2 atm of pressure and has 12.7-μm-thick titanium entrance and exit foils. The total mass exposed to the beam is 0.14 g/cm2 and is dominated by the titanium windows. This mass corresponds to a range attenuation equal to 1.4 mm of water. The energy lost to the xenon gas is about 70 keV per proton. Each passing proton will produce approximately 2000 photons. With a detection efficiency on the order of 0.05% for this UV light, one would anticipate over 1010 photoelectrons per second. In a 1-ms time bin there will be approximately 107 photoelectrons. This yields a resolution limited by systematics. For unregulated 0.4-s proton spills, we observe a response bandwidth in excess of 104 Hz. While signal-to-noise and linearity were not easily measured, we estimate as few as 103 protons can be observed suggesting a dynamic range in excess of 105 is available

  15. A beam intensity monitor for the Loma Linda cancer therapy proton accelerator.

    Science.gov (United States)

    Coutrakon, G; Miller, D; Kross, B J; Anderson, D F; DeLuca, P; Siebers, J

    1991-01-01

    A beam intensity monitor was tested in a 230-MeV proton beam at the Loma Linda Proton Therapy Accelerator during its commissioning at Fermi National Accelerator Laboratory. The intensity monitor was designed to regulate the beam intensity extracted from the proton synchrotron. The proton beam is tunable between 70 and 250 MeV with an adjustable intensity between 10(10) and 10(11) protons per spill. A beam spill is typically 1 s long with a 2-s repetition period. The intensity monitor must be radiation hard, expose minimum mass to the beam, and measure intensity to 1% in 1-ms time intervals. To this end, a 5-cm-thick xenon gas scintillator optically coupled to a photomultiplier tube (PMT) was tested to measure its response to the proton beam. The gas cell was operated at 1.2 atm of pressure and has 12.7-microns-thick titanium entrance and exit foils. The total mass exposed to the beam is 0.14 g/cm2 and is dominated by the titanium windows. This mass corresponds to a range attenuation equal to 1.4 mm of water. The energy lost to the xenon gas is about 70 keV per proton. Each passing proton will produce approximately 2000 photons. With a detection efficiency on the order of 0.05% for this UV light, one would anticipate over 10(10) photoelectrons per second. In a 1-ms time bin there will be approximately 10(7) photoelectrons. This yields a resolution limited by systematics. For unregulated 0.4-s proton spills, we observe a response bandwidth in excess of 10(4) Hz. While signal-to-noise and linearity were not easily measured, we estimate as few as 10(3) protons can be observed suggesting a dynamic range in excess of 10(5) is available. PMID:1656180

  16. External beam radiation therapy and retinoblastoma: Long-term results in the comparison of two techniques

    International Nuclear Information System (INIS)

    Purpose: This study compares the long-term actuarial local control, eye conservation rate, survival, and ocular complications in children with retinoblastoma treated with two different external beam treatment techniques. Methods and Materials: From 1979-1991, 182 eyes in 123 children (104 bilateral) received primary external beam radiation therapy. An anterior lens-sparing electron beam technique delivering 38 to 50 Gy in 2.5 Gy fractions was used in 67 eyes from 1979-1984 and a modified lateral beam technique, delivering 42 to 46 Gy in 2 Gy fractions, was used in 113 eyes from 1984-1991. These groups were balanced with respect to known prognostic variables. Results: For Group I-III eyes, the 5- and 8-year local control was significantly improved using the modified lateral beam technique (84%) compared to (38%) using the anterior lens sparing technique (p p ≤ 0.0001). For Group IV-V eyes, the 5- and 8-year local control rates were not statistically different, despite a trend favoring the modified lateral beam technique. Survival endpoints including eye survival (no enucleation), cause-specific survival, and overall survival comparing the two treatment techniques were not significantly different. Overall, 22% of eyes developed cataracts. There was no difference between the two treatment groups in terms of cataract development. No eyes required enucleation for ocular complications. Conclusion: There is a significant improvement in local control using the modified lateral beam technique compared to an anterior lens-sparing approach for Group I-III eyes. However, there was no difference in survival end points between the two treatment techniques. The incidence of ocular complications using these two external beam techniques is acceptable.

  17. Development of high intensity ion sources for a Tandem-Electrostatic-Quadrupole facility for Accelerator-Based Boron Neutron Capture Therapy

    International Nuclear Information System (INIS)

    Several ion sources have been developed and an ion source test stand has been mounted for the first stage of a Tandem-Electrostatic-Quadrupole facility For Accelerator-Based Boron Neutron Capture Therapy. A first source, designed, fabricated and tested is a dual chamber, filament driven and magnetically compressed volume plasma proton ion source. A 4 mA beam has been accelerated and transported into the suppressed Faraday cup. Extensive simulations of the sources have been performed using both 2D and 3D self-consistent codes.

  18. The Missing Pieces in Reporting of Randomized Controlled Trials of External Beam Radiation Therapy Dose Escalation for Prostate Cancer.

    Science.gov (United States)

    Zaorsky, Nicholas G; Egleston, Brian L; Horwitz, Eric M; Dicker, Adam P; Nguyen, Paul L; Showalter, Timothy N; Den, Robert B

    2016-08-01

    Randomized controlled trials (RCTs) are the most rigorous way of determining whether a cause-effect relation exists between treatment and outcome and for assessing the cost-effectiveness of a treatment. For many patients, cancer is a chronic illness; RCTs evaluating treatments for indolent cancers must evolve to facilitate medical decision-making, as "concrete" patient outcomes (eg, survival) will likely be excellent independent of the intervention, and detecting a difference between trial arms may be impossible. In this commentary, we articulate 9 recommendations that we hope future clinical trialists and funding agencies (including those under the National Cancer Institute) will take into consideration when planning RCTs to help guide subsequent interpretation of results and clinical decision making, based on RCTs of external beam radiation therapy dose escalation for the most common indolent cancer in men, that is, prostate cancer. We recommend routinely reporting: (1) race; (2) medical comorbidities; (3) psychiatric comorbidities; (4) insurance status; (5) education; (6) marital status; (7) income; (8) sexual orientation; and (9) facility-related characteristics (eg, number of centers involved, type of facilities, yearly hospital volumes). We discuss how these factors independently affect patient outcomes and toxicities; future clinicians and governing organizations should consider this information to plan RCTs accordingly (to maximize patient accrual and total n), select appropriate endpoints (eg, toxicity, quality of life, sexual function), actively monitor RCTs, and report results so as to identify the optimal treatment among subpopulations. PMID:27322694

  19. FEASIBILITY OF POSITRON EMISSION TOMOGRAPHY OF DOSE DISTRIBUTION IN PROTON BEAM CANCER THERAPY.

    Energy Technology Data Exchange (ETDEWEB)

    BEEBE - WANG,J.J.; DILMANIAN,F.A.; PEGGS,S.G.; SCHLYEER,D.J.; VASKA,P.

    2002-06-03

    Proton therapy is a treatment modality of increasing utility in clinical radiation oncology mostly because its dose distribution conforms more tightly to the target volume than x-ray radiation therapy. One important feature of proton therapy is that it produces a small amount of positron-emitting isotopes along the beam-path through the non-elastic nuclear interaction of protons with target nuclei such as {sup 12}C, {sup 14}N, and {sup 16}O. These radioisotopes, mainly {sup 11}C, {sup 13}N and {sup 15}O, allow imaging the therapy dose distribution using positron emission tomography (PET). The resulting PET images provide a powerful tool for quality assurance of the treatment, especially when treating inhomogeneous organs such as the lungs or the head-and-neck, where the calculation of the dose distribution for treatment planning is more difficult. This paper uses Monte Carlo simulations to predict the yield of positron emitters produced by a 250 MeV proton beam, and to simulate the productions of the image in a clinical PET scanner.

  20. Report on selected concerns regarding property accountability at the Continuous Electron Beam Accelerator facility

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-11-24

    The Continuous Electron Beam Accelerator Facility (CEBAF) is a federally funded research and development center at Newport News, Virginia, At the time of our review, Southeastern Universities Research Association (SURA) was operating CEBAF for the Department of Energy (DOE) under a management and operating (M&O) contract administered by DOE`s Oak Ridge Operations Office. SURA is currently operating CEBAF under a performance based management contract, The purpose of our inspection was to evaluate selected management issues regarding property accountability at CEBAF that we identified as a result of a complaint received by the Office of Inspector General. The complainant alleged a lack of accountability for Government equipment at CEBAF and the lack of an equipment inventory. Specifically, the complainant alleged, among other things, that after a named supervisor departed, CEBAF personnel had no idea what equipment had been assigned to the supervisor and could not account for any missing materials.