WorldWideScience

Sample records for beam therapy facility

  1. Proton beam therapy facility

    International Nuclear Information System (INIS)

    1984-01-01

    It is proposed to build a regional outpatient medical clinic at the Fermi National Accelerator Laboratory (Fermilab), Batavia, Illinois, to exploit the unique therapeutic characteristics of high energy proton beams. The Fermilab location for a proton therapy facility (PTF) is being chosen for reasons ranging from lower total construction and operating costs and the availability of sophisticated technical support to a location with good access to patients from the Chicago area and from the entire nation. 9 refs., 4 figs., 26 tabs

  2. Treatment facilities, human resource development, and future prospect of particle beam therapy

    International Nuclear Information System (INIS)

    Tamaki, Tomoaki; Nakano, Takashi

    2015-01-01

    The number of particle beam therapy facilities is increasing globally. Among the countries practicing particle beam therapy, Japan is one of the leading countries in the field with four operating carbon-ion therapy facilities and ten operating proton therapy facilities. With the increasing number of particle beam therapy facilities, the human resource development is becoming extremely important, and there has been many such efforts including the Gunma University Program for Cultivating Global Leaders in Heavy Ion Therapeutics and Engineering, which aimed to educate and train the radiation oncologists, medical physicists, accelerator engineers, and radiation biologists to become global leaders in the field of particle beam therapy. In the future, the benefit and effectiveness of particle beam therapy should be discussed and elucidated objectively in a framework of comprehensive cancer care. (author)

  3. Neutron Therapy Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Neutron Therapy Facility provides a moderate intensity, broad energy spectrum neutron beam that can be used for short term irradiations for radiobiology (cells)...

  4. Opening and construction of facilities in succession for particle beam therapy of cancer

    International Nuclear Information System (INIS)

    Nakano, Takashi; Yamamoto, Kazutaka; Hishikawa, Yoshio; Totoki, Tadahide; Hoshino, Junichi; Aoki, Takashi; Yoshiyuki, Takeshi; Hirabayashi, Masayuki; Nakamura, Fumito

    2011-01-01

    This feature article describes the current state of practical particle beam therapy of cancer, its future prospect, recent opening/construction of its facilities and manufacturers' view with following 9 topics presented by relevant experts. Gunma University (topic 1) started the carbon ion therapy from Mar., 2010, and has treated more than 100 cancer patients to aim the treatment of about 600 patients/year after several years. Fukui Prefectural Hospital Proton Therapy Center (topic 2) started from this March with proton beams for patients with its therapeutic standard, in cooperation with insurance companies and hotels for patients' convenience. Medipolis Proton Therapy and Research Center (Kagoshima Pref.) (topic 3) started this year with proton beams for 13 patients hitherto with reference protocol of Hyogo Ion Beam Medical Center. A new stereotactic irradiation system of proton beams for breast cancer has been developed. Construction of Saga Heavy Ion Medical Accelerator in Tosu (Saga Pref.) (topic 4) began this year to be completed in 2013. Aizawa Hospital (Nagano Pref.) (topic 5) plans to introduce the small-sized proton accelerator-gantry system (Sumitomo Heavy Ind., Ltd.) aiming the practice in 2013. Association for Nuclear Technology in Medicine (topic 6) reports the trends of current and future construction inside/outside Japan. Manufacturers comment their respective business: high-speed scanning irradiation system, next generation handling system of patient and particle beam therapy information system by Toshiba (topic 7); designation of the whole heavy ion beam therapy system (with NIRS), proton beam (as in topic 5) and system of BNCT (boron neutron-capture therapy) (Kyoto Univ.) by Sumitomo Heavy Ind., Ltd. (topic 8); and small-size proton therapeutic machine with 4D tracing capability for patient's movement (Hokkaido Univ.) and with spot-scanning irradiation technique by Hitachi (topic 9). (author)

  5. Evolution of a beam dynamics model for the transport line in a proton therapy facility

    Science.gov (United States)

    Rizzoglio, V.; Adelmann, A.; Baumgarten, C.; Frey, M.; Gerbershagen, A.; Meer, D.; Schippers, J. M.

    2017-12-01

    During the conceptual design of an accelerator or beamline, first-order beam dynamics models are essential for studying beam properties. However, they can only produce approximate results. During commissioning, these approximate results are compared to measurements, which will rarely coincide if the model does not include the relevant physics. It is therefore essential that this linear model is extended to include higher-order effects. In this paper, the effects of particle-matter interaction have been included in the model of the transport lines in the proton therapy facility at the Paul Scherrer Institut (PSI) in Switzerland. The first-order models of these beamlines provide an approximated estimation of beam size, energy loss and transmission. To improve the performance of the facility, a more precise model was required and has been developed with opal (Object Oriented Parallel Accelerator Library), a multiparticle open source beam dynamics code. In opal, the Monte Carlo simulations of Coulomb scattering and energy loss are performed seamless with the particle tracking. Beside the linear optics, the influence of the passive elements (e.g., degrader, collimators, scattering foils, and air gaps) on the beam emittance and energy spread can be analyzed in the new model. This allows for a significantly improved precision in the prediction of beam transmission and beam properties. The accuracy of the opal model has been confirmed by numerous measurements.

  6. Dosimetric characteristics of the thermal neutron beam facility for neutron capture therapy at Hanaro reactor

    International Nuclear Information System (INIS)

    Lee, Dong Han; Suh, Soheigh; Ji, Young Hoon

    2006-01-01

    The thermal neutron beam facility utilizing a typical tangential beam port for Neutron Capture Therapy was installed at the Hanaro, 30 MW multi-purpose research reactor. In order to determine the different dose components in phantoms irradiated with a mixed thermal neutron beam and gamma-ray for clinical applications, various techniques were applied including the use of activation foils, TLDs and ionization chambers. The water phantom was utilized in the measurement. The results of the measurement were compared with MCNP4B calculations. The thermal neutron fluxes were 1.02E9 and 6.07E8/cm 2 ·s at 10 and 20 mm depth in water, respectively. The gamma-ray dose rate was 5.10 Gy/hr at 20 mm depth in water. The result of this study can be used as basic data for subsequent BNCT clinical application. (author)

  7. Proton beam characterization in the experimental room of the Trento Proton Therapy facility

    Science.gov (United States)

    Tommasino, F.; Rovituso, M.; Fabiano, S.; Piffer, S.; Manea, C.; Lorentini, S.; Lanzone, S.; Wang, Z.; Pasini, M.; Burger, W. J.; La Tessa, C.; Scifoni, E.; Schwarz, M.; Durante, M.

    2017-10-01

    As proton therapy is becoming an established treatment methodology for cancer patients, the number of proton centres is gradually growing worldwide. The economical effort for building these facilities is motivated by the clinical aspects, but might be also supported by the potential relevance for the research community. Experiments with high-energy protons are needed not only for medical physics applications, but represent also an essential part of activities dedicated to detector development, space research, radiation hardness tests, as well as of fundamental research in nuclear and particle physics. Here we present the characterization of the beam line installed in the experimental room of the Trento Proton Therapy Centre (Italy). Measurements of beam spot size and envelope, range verification and proton flux were performed in the energy range between 70 and 228 MeV. Methods for reducing the proton flux from typical treatments values of 106-109 particles/s down to 101-105 particles/s were also investigated. These data confirm that a proton beam produced in a clinical centre build by a commercial company can be exploited for a broad spectrum of experimental activities. The results presented here will be used as a reference for future experiments.

  8. More than 10 years experience of beam monitoring with the Gantry 1 spot scanning proton therapy facility at PSI

    International Nuclear Information System (INIS)

    Lin Shixiong; Boehringer, Terence; Coray, Adolf; Grossmann, Martin; Pedroni, Eros

    2009-01-01

    Purpose: The beam monitoring equipments developed for the first PSI spot scanning proton therapy facility, Gantry 1, have been successfully used for more than 10 years. The purpose of this article is to summarize the author's experience in the beam monitoring technique for dynamic proton scanning. Methods: The spot dose delivery and verification use two independent beam monitoring and computer systems. In this article, the detector construction, electronic system, dosimetry, and quality assurance results are described in detail. The beam flux monitor is calibrated with a Faraday cup. The beam position monitoring is realized by measuring the magnetic fields of deflection magnets with Hall probes before applying the spot and by checking the beam position and width with an ionization strip chamber after the spot delivery. Results: The results of thimble ionization chamber dosimetry measurements are reproducible (with a mean deviation of less than 1% and a standard deviation of 1%). The resolution in the beam position measurement is of the order of a tenth of a millimeter. The tolerance of the beam position delivery and monitoring during scanning is less than 1.5 mm. Conclusions: The experiences gained with the successful operation of Gantry 1 represent a unique and solid background for the development of a new system, Gantry 2, in order to perform new advanced scanning techniques.

  9. More than 10 years experience of beam monitoring with the Gantry 1 spot scanning proton therapy facility at PSI

    Energy Technology Data Exchange (ETDEWEB)

    Lin Shixiong; Boehringer, Terence; Coray, Adolf; Grossmann, Martin; Pedroni, Eros [Center for Proton Therapy, Paul Scherrer Institute, CH-5232 Villigen PSI (Switzerland)

    2009-11-15

    Purpose: The beam monitoring equipments developed for the first PSI spot scanning proton therapy facility, Gantry 1, have been successfully used for more than 10 years. The purpose of this article is to summarize the author's experience in the beam monitoring technique for dynamic proton scanning. Methods: The spot dose delivery and verification use two independent beam monitoring and computer systems. In this article, the detector construction, electronic system, dosimetry, and quality assurance results are described in detail. The beam flux monitor is calibrated with a Faraday cup. The beam position monitoring is realized by measuring the magnetic fields of deflection magnets with Hall probes before applying the spot and by checking the beam position and width with an ionization strip chamber after the spot delivery. Results: The results of thimble ionization chamber dosimetry measurements are reproducible (with a mean deviation of less than 1% and a standard deviation of 1%). The resolution in the beam position measurement is of the order of a tenth of a millimeter. The tolerance of the beam position delivery and monitoring during scanning is less than 1.5 mm. Conclusions: The experiences gained with the successful operation of Gantry 1 represent a unique and solid background for the development of a new system, Gantry 2, in order to perform new advanced scanning techniques.

  10. Maximum dose angle for oblique incidence on primary beam protective barriers in the design of medical radiation therapy facilities

    International Nuclear Information System (INIS)

    Fondevila, Damian; Arbiser, Silvio; Sansogne, Rosana; Brunetto, Monica; Dosoretz, Bernardo

    2008-01-01

    Primary barrier determinations for the shielding of medical radiation therapy facilities are generally made assuming normal beam incidence on the barrier, since this is geometrically the most unfavorable condition for that shielding barrier whenever the occupation line is allowed to run along the barrier. However, when the occupation line (for example, the wall of an adjacent building) runs perpendicular to the barrier (especially roof barrier), then two opposing factors come in to play: increasing obliquity angle with respect to the barrier increases the attenuation, while the distance to the calculation point decreases, hence, increasing the dose. As a result, there exists an angle (α max ) for which the equivalent dose results in a maximum, constituting the most unfavorable geometric condition for that shielding barrier. Based on the usual NCRP Report No. 151 model, this article presents a simple formula for obtaining α max , which is a function of the thickness of the barrier (t E ) and the equilibrium tenth-value layer (TVL e ) of the shielding material for the nominal energy of the beam. It can be seen that α max increases for increasing TVL e (hence, beam energy) and decreases for increasing t E , with a range of variation that goes from 13 to 40 deg for concrete barriers thicknesses in the range of 50-300 cm and most commercially available teletherapy machines. This parameter has not been calculated in the existing literature for radiotherapy facilities design and has practical applications, as in calculating the required unoccupied roof shielding for the protection of a nearby building located in the plane of the primary beam rotation

  11. Getting Ready for Ion-Beam Therapy Research in Austria - Building-up Research in Parallel with a Facility

    International Nuclear Information System (INIS)

    Georg, Dietmar; Knaeusl; Kuess, Peter; Fuchs, Hermann; Poetter, Richard; Schreiner, Thomas

    2015-01-01

    With participation in ion-beam projects funded nationally or by the European Commission (EC), ion-beam research activities were started at the Medical University of Vienna in parallel with the design and construction of the ion-beam center MedAustron in Wiener Neustadt, 50 km from the Austrian capital. The current medical radiation physics research activities that will be presented comprise: (1) Dose calculation and optimization: ion-beam centers focus mostly on proton and carbon-ion therapy. However, there are other ion species with great potential for clinical applications. Helium ions are currently under investigation from a theoretical physics and biology perspective. (2) Image guided and adaptive ion-beam therapy: organ motion and anatomic changes have a severe influence in ion-beam therapy since variations in heterogeneity along the beam path have a significant impact on the particle range. Ongoing research focuses on possibilities to account for temporal variations of the anatomy during radiotherapy. Both during and between fractions also considering temporal variations in tumor biology. Furthermore, research focuses on particle therapy positron emission tomography (PT-PET) verification and the detection of prompt gammas for on-line verification of ion-beam delivery. (3) Basic and applied dosimetry: an end-to-end procedure was designed and successfully tested in both scanned proton and carbon-ion beams, which may also serve as a dosimetric credentialing procedure for clinical trials in the future. (Author)

  12. Electrostatic design and beam transport for a folded tandem electrostatic quadrupole accelerator facility for accelerator-based boron neutron capture therapy

    Energy Technology Data Exchange (ETDEWEB)

    Thatar Vento, V., E-mail: Vladimir.ThatarVento@gmail.com [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral. Paz 1499 (1650), San Martin, Buenos Aires (Argentina)] [CONICET, Av. Rivadavia 1917 (1033), Ciudad Autonoma de Buenos Aires (Argentina); Bergueiro, J.; Cartelli, D. [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral. Paz 1499 (1650), San Martin, Buenos Aires (Argentina)] [CONICET, Av. Rivadavia 1917 (1033), Ciudad Autonoma de Buenos Aires (Argentina); Valda, A.A. [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral. Paz 1499 (1650), San Martin, Buenos Aires (Argentina)] [Escuela de Ciencia y Tecnologia, UNSAM, M. Irigoyen 3100 (1650), San Martin, Buenos Aires (Argentina); Kreiner, A.J. [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral. Paz 1499 (1650), San Martin, Buenos Aires (Argentina)] [CONICET, Av. Rivadavia 1917 (1033), Ciudad Autonoma de Buenos Aires (Argentina)] [Escuela de Ciencia y Tecnologia, UNSAM, M. Irigoyen 3100 (1650), San Martin, Buenos Aires (Argentina)

    2011-12-15

    Within the frame of an ongoing project to develop a folded Tandem-Electrostatic-Quadrupole (TESQ) accelerator facility for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT), we discuss here the electrostatic design of the machine, including the accelerator tubes with electrostatic quadrupoles and the simulations for the transport and acceleration of a high intensity beam.

  13. Laser Produced Ions as an Injection Beam for Cancer Therapy Facility

    CERN Document Server

    Noda, A; Iwashita, Y; Nakamura, S; Sakabe, S; Shimizu, S; Shirai, T; Tongu, H

    2004-01-01

    Ion production from a solid target by a high-power short pulse laser has been investigated to replace the injector linac of the synchrotron dedicated for cancer therapy. As the high power laser, the laser with the peak power of 100 TW and minimum pulse duration of 20 fs which has been developed at JAERI Kansai Research Establishment, is assumed. Laser produced ions with 100% energy spread is energy selected within ±5% and then phase rotated with use of the RF electric field synchronized to the pulse laser, which further reduces the energy spread to ±1%. The scheme of the phase rotation is presented together with the experimental results of laser production from the thin foil target.

  14. The radioactive beam facility ALTO

    International Nuclear Information System (INIS)

    Essabaa, Saïd; Barré-Boscher, Nicole; Cheikh Mhamed, Maher; Cottereau, Evelyne; Franchoo, Serge; Ibrahim, Fadi; Lau, Christophe; Roussière, Brigitte; Saïd, Abdelhakim; Tusseau-Nenez, Sandrine; Verney, David

    2013-01-01

    Highlights: • Research at the ALTO TNA-facility. • R and D on radioactive ion sources. • R and D on the lanthanide beam production by fluorination. • Recent developments on uranium carbide targets. -- Abstract: The Transnational Access facility ALTO (TNA07-ENSAR/FP7) has been commissioned and received from the French safety authorities, the operation license. It is allowed to run at nominal intensity to produce 10 11 fissions/s in a thick uranium carbide target by photo-fission using a 10 μA, 50 MeV electron beam. In addition the recent success in operating the selective laser ion source broadens the physics program with neutron-rich nuclear beams possible at this facility installed at IPN Orsay. The facility also aims at being a test bench for the SPIRAL2 project. In that framework an ambitious R and D program on the target ion source system is being developed

  15. Electrostatic design and beam transport for a folded tandem electrostatic quadrupole accelerator facility for accelerator-based boron neutron capture therapy.

    Science.gov (United States)

    Vento, V Thatar; Bergueiro, J; Cartelli, D; Valda, A A; Kreiner, A J

    2011-12-01

    Within the frame of an ongoing project to develop a folded Tandem-Electrostatic-Quadrupole (TESQ) accelerator facility for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT), we discuss here the electrostatic design of the machine, including the accelerator tubes with electrostatic quadrupoles and the simulations for the transport and acceleration of a high intensity beam. Copyright © 2011 Elsevier Ltd. All rights reserved.

  16. Ion Beam Therapy in Europe

    International Nuclear Information System (INIS)

    Kraft, Gerhard

    2009-01-01

    At present, seven facilities in Europe treat deep-seated tumors with particle beams, six with proton beams and one with carbon ions. Three of these facilities are in Moscow, St. Petersburg and Dubna, Russia. Other facilities include the TSL Uppsala, Sweden, CPO Orsay, France, and PSI Villigen, Switzerland, all for proton therapy, and GSI, Darmstadt, Germany, which utilizes carbon ions only. But only two of these facilities irradiate with scanned ion beams: the Paul Scherer Institute (PSI), Villigen (protons) and the Gesellschaft fuer Schwerionenforschung (GSI), Darmstadt. These two facilities are experimental units within physics laboratories and have developed the technique of intensity-modulated beam scanning in order to produce irradiation conforming to a 3-D target. There are three proton centers presently under construction in Munich, Essen and Orsay, and the proton facility at PSI has added a superconducting accelerator connected to an isocentric gantry in order to become independent of the accelerator shared with the physics research program. The excellent clinical results using carbon ions at National Institute of Radiological Science (NIRS) in Chiba and GSI have triggered the construction of four new heavy-ion therapy projects (carbon ions and protons), located in Heidelberg, Pavia, Marburg and Kiel. The projects in Heidelberg and Pavia will begin patient treatment in 2009, and the Marburg and Kiel projects will begin in 2010 and 2011, respectively. These centers use different accelerator designs but have the same kind of treatment planning system and use the same approach for the calculation of the biological effectiveness of the carbon ions as developed at GSI [1]. There are many other planned projects in the works. Do not replace the word ''abstract,'' but do replace the rest of this text. If you must insert a hard line break, please use Shift+Enter rather than just tapping your ''Enter'' key. You may want to print this page and refer to it as a style

  17. Beam instrumentation in a multidisciplinary accelerator facility

    NARCIS (Netherlands)

    Schippers, J.M.; Boon, S.N.; Dermois, O.C.; Kiewiet, H.H.

    Some recently developed beam diagnostic devices for the beam lines of the AGOR cyclotron are reviewed. The range of applications is from low background nuclear physics experiments at "zero degree" to radiation therapy with proton beams. In particular a method to improve beam quality and the

  18. SU-E-T-388: Estimating the Radioactivity Inventory of a Cyclotron Based Pencil Beam Proton Therapy Facility

    Energy Technology Data Exchange (ETDEWEB)

    Langen, K; Chen, S [University of Maryland School of Medicine, Baltimore, MD (United States)

    2014-06-01

    Purpose: Parts of the cyclotron and energy degrader are incidentally activated by protons lost during the acceleration and transport of protons for radiation therapy. An understanding of the radioactive material inventory is needed when regulatory requirements are assessed. Methods: First, the tumor dose and volume is used to determine the required energy deposition. For spot scanning, the tumor length along the beam path determines the number of required energy layers. For each energy layer the energy deposition per proton can be calculated from the residual proton range within the tumor. Assuming a typical layer weighting, an effective energy deposition per proton can then be calculated. The total number of required protons and the number of protons per energy layer can then be calculated. For each energy layer, proton losses in the energy degrader are calculated separately since its transmission efficiency, and hence the amount of protons lost, is energy dependent. The degrader efficiency also determines the number of protons requested from the cyclotron. The cyclotron extraction efficiency allows a calculation of the proton losses within the cyclotron. The saturation activity induced in the cyclotron and the degrader is equal to the production rate R for isotopes whose half-life is shorter that the projected cyclotron life time. R can be calculated from the proton loss rate and published production cross sections. Results: About 1/3 of the saturation activity is produced in the cyclotron and 2/3 in the energy degrader. For a projected case mix and a patient load of 1100 fractions per week at 1.8 Gy per fraction a combined activity of 180 mCi was estimated at saturation. Conclusion: Calculations were used to support to application of a radioactive materials license for the possession of 200 mCi of activity for isotopes with atomic numbers ranging from 1-83.

  19. SU-E-T-388: Estimating the Radioactivity Inventory of a Cyclotron Based Pencil Beam Proton Therapy Facility

    International Nuclear Information System (INIS)

    Langen, K; Chen, S

    2014-01-01

    Purpose: Parts of the cyclotron and energy degrader are incidentally activated by protons lost during the acceleration and transport of protons for radiation therapy. An understanding of the radioactive material inventory is needed when regulatory requirements are assessed. Methods: First, the tumor dose and volume is used to determine the required energy deposition. For spot scanning, the tumor length along the beam path determines the number of required energy layers. For each energy layer the energy deposition per proton can be calculated from the residual proton range within the tumor. Assuming a typical layer weighting, an effective energy deposition per proton can then be calculated. The total number of required protons and the number of protons per energy layer can then be calculated. For each energy layer, proton losses in the energy degrader are calculated separately since its transmission efficiency, and hence the amount of protons lost, is energy dependent. The degrader efficiency also determines the number of protons requested from the cyclotron. The cyclotron extraction efficiency allows a calculation of the proton losses within the cyclotron. The saturation activity induced in the cyclotron and the degrader is equal to the production rate R for isotopes whose half-life is shorter that the projected cyclotron life time. R can be calculated from the proton loss rate and published production cross sections. Results: About 1/3 of the saturation activity is produced in the cyclotron and 2/3 in the energy degrader. For a projected case mix and a patient load of 1100 fractions per week at 1.8 Gy per fraction a combined activity of 180 mCi was estimated at saturation. Conclusion: Calculations were used to support to application of a radioactive materials license for the possession of 200 mCi of activity for isotopes with atomic numbers ranging from 1-83

  20. Electron beams in radiation therapy

    International Nuclear Information System (INIS)

    Bruinvis, I.A.D.

    1987-01-01

    Clinical electron beams in interaction with beam flattening and collimating devices are studied, in order to obtain the means for adequate electron therapy. A treatment planning method for arbitrary field shapes is developed that takes the properties of the collimated electron beams into account. An electron multiple-scattering model is extended to incorporate a model for the loss of electrons with depth, in order to improve electron beam dose planning. A study of ionisation measurements in two different phantom materials yields correction factors for electron beam dosimetry. (Auth.)

  1. Facilities for radiotherapy with ion beams status and worldwide developments

    CERN Document Server

    Wolf, B H

    1999-01-01

    Forty-five years after the first ion beam therapy in Berkeley around 25,000 cancer patients worldwide have been treated successfully. Ion accelerators, designed for nuclear research, delivered most of this treatment. The first hospital-based facility started operation in 1998 at Loma Linda California, the first for heavier ions at Chiba, Japan in 1994 and the first commercially delivered facilities started operation in 1998 at Kashiwa, Japan. In 2000, the Harvard Medical Centre, Boston, US, will commence operation and several new facilities are planned or under construction worldwide, although none in Australia. This paper will discuss the physical and biological advantages of ion beams over x-rays and electrons. In the treatment of cancer patients ion beam therapy is especially suited for localised tumours in radiation sensitive areas like skull or spine. Heavier ions are also effective in anoxic tumour cells (found around the normally oxygenated cell population). An additional advantage of the heavier carbo...

  2. Development of cancer therapy facility of HANARO

    International Nuclear Information System (INIS)

    Jun, Byung Jin; Hwang, S. Y.; Kim, M. J. and others

    2000-04-01

    Facilities of the research and clinical treatments of neutron capture therapy using HANARO are developed, and they are ready to install. They are BNCT irradiation facility and prompt gamma neutron activatiion analysis facility. Since every horizontal neutron facility of HANARO is long and narrow tangential beam tube, it is analysed that sufficient epithermal neutrons for the BNCT cannot be obtained but sufficient thermal neutrons can be obtained by a filter composed of silicon and bismuth single crystals. Since the thermal neutron penetaration increases significantly when the crystals are cooled, a filter cooled by liquid nitrogen is developed. So as to avoid interference with the reactor operation, a water shutter is developed. The irradiation room is designed for the temporary surgical operation as well. Handling tools to remove activated beam port plug and to install water shutter and filter are developed. The basic structure of the irradiation room is already installed and most of other parts are ready to install. Since no free beam port is available for the prompt gamma neutron activation analysis, a method obtaining almost pure thermal neutrons by the vertical diffraction of extra beam for the polarized neutron spectrometer is developed. This method is confirmed by analysis and experiments to give high enough neutron beam. Equipment and devices are provided to install this facility

  3. Development of cancer therapy facility of HANARO

    Energy Technology Data Exchange (ETDEWEB)

    Jun, Byung Jin; Hwang, S. Y.; Kim, M. J. and others

    2000-04-01

    Facilities of the research and clinical treatments of neutron capture therapy using HANARO are developed, and they are ready to install. They are BNCT irradiation facility and prompt gamma neutron activatiion analysis facility. Since every horizontal neutron facility of HANARO is long and narrow tangential beam tube, it is analysed that sufficient epithermal neutrons for the BNCT cannot be obtained but sufficient thermal neutrons can be obtained by a filter composed of silicon and bismuth single crystals. Since the thermal neutron penetaration increases significantly when the crystals are cooled, a filter cooled by liquid nitrogen is developed. So as to avoid interference with the reactor operation, a water shutter is developed. The irradiation room is designed for the temporary surgical operation as well. Handling tools to remove activated beam port plug and to install water shutter and filter are developed. The basic structure of the irradiation room is already installed and most of other parts are ready to install. Since no free beam port is available for the prompt gamma neutron activation analysis, a method obtaining almost pure thermal neutrons by the vertical diffraction of extra beam for the polarized neutron spectrometer is developed. This method is confirmed by analysis and experiments to give high enough neutron beam. Equipment and devices are provided to install this facility.

  4. Radiation therapy facilities in the United States

    International Nuclear Information System (INIS)

    Ballas, Leslie K.; Elkin, Elena B.; Schrag, Deborah; Minsky, Bruce D.; Bach, Peter B.

    2006-01-01

    Purpose: About half of all cancer patients in the United States receive radiation therapy as a part of their cancer treatment. Little is known, however, about the facilities that currently deliver external beam radiation. Our goal was to construct a comprehensive database of all radiation therapy facilities in the United States that can be used for future health services research in radiation oncology. Methods and Materials: From each state's health department we obtained a list of all facilities that have a linear accelerator or provide radiation therapy. We merged these state lists with information from the American Hospital Association (AHA), as well as 2 organizations that audit the accuracy of radiation machines: the Radiologic Physics Center (RPC) and Radiation Dosimetry Services (RDS). The comprehensive database included all unique facilities listed in 1 or more of the 4 sources. Results: We identified 2,246 radiation therapy facilities operating in the United States as of 2004-2005. Of these, 448 (20%) facilities were identified through state health department records alone and were not listed in any other data source. Conclusions: Determining the location of the 2,246 radiation facilities in the United States is a first step in providing important information to radiation oncologists and policymakers concerned with access to radiation therapy services, the distribution of health care resources, and the quality of cancer care

  5. World new facilities for radioactive isotope beams

    International Nuclear Information System (INIS)

    Motobayashi, T.

    2014-01-01

    The use of unstable nuclei in the form of energetic beams for nuclear physics studies is now entering into a new era. 'New-generation' facilities are either in operation, under construction or being planned. They are designed to provide radioactive isotope (RI) beams with very high intensities over a wide range of nuclides. These facilities are expected to provide opportunities to study nuclear structure, astrophysical nuclear processes and nuclear matter with large proton-neutron imbalance in grate detail. This article reports on the current status of such new-generation RI-beam facilities around the world. In order to cover different energy domains and to meet various scientific demands, the designs of RI-beam facilities are of a wide variety. For example, RIBF in Japan, FAIR in Germany and FRIB in US are based on the fragmentation scheme for beams with energies of a few hundred MeV/nucleon to GeV/nucleon, whereas Spiral2 in France, SPES in Italy, HIE-ISOLDE in Switzerland/France, and the future facility EURISOL in Europe are based on the ISOL method, and aim at providing lower-energy RI beams. There are a many other projects including upgrades of existing facilities in the three continents, America, Asia and Europe

  6. Radioactive ion beam facilities in Europe

    International Nuclear Information System (INIS)

    Blumenfeld, Y.

    2008-01-01

    The past two decades have seen extraordinarily rapid development of radioactive beam physics throughout the world and in particular in Europe. The important scientific advances have stemmed from a large number of facilities. Previously existing stable beam machines have been adapted to produce rare isotope beams and dedicated facilities have come on-line. This talk gives an overview of the present European installations highlighting their complementary nature. The European roadmap calls for the construction of two next generation facilities: FAIR making use of projectile fragmentation and EURISOL based on the ISOL technique. The future FAIR facility will be described and the path towards EURISOL presented in the light of the construction of 'intermediate' generation facilities SPIRAL2, HIE ISOLDE and SPES and results from the ongoing EURISOL Design Study.

  7. Review of ion beam therapy: Present and Future

    Energy Technology Data Exchange (ETDEWEB)

    Alonso, Jose R.

    2000-06-01

    First therapy efforts at the Bevalac using neon ions took place in the 70's and 80's. Promising results led to construction of HIMAC in Chiba Japan, and more recently to therapy trials at GSI. Both these facilities are now treating patients with carbon beams. Advances in both accelerator technology and beam delivery have taken place at these two centers. Plans are well along for new facilities in Europe and Japan.

  8. The ISOLDE Facility: Radioactive beams at CERN

    CERN Multimedia

    CERN. Geneva

    2007-01-01

    The Isope Separation On-Line (ISOL) technique evolved from chemical techniques used to separate radioactive isotopes off-line from irradiated "targets". The ISOL targets of today, used at e.g. ISOLDE, can be of many different types and in different phases but the isotopes are always delivered at very low energies making the technique ideal for study of ground state properties and collections for other applications such as solid state physics and medical physics. The possibility of accelerating these low energy beams for nuclear structure studies, and in the long term future for neutrino physics, is now being explored at first generation radioactive beam facilities. The upgrade towards HIE-ISOLDE aim to consolidate ISOLDE's position as a world leading radioactive nuclear beam facility and it will be a pre-cursor to a future all European ISOL facility, EURISOL, with order of magnitudes higher radioactive beam intensities and energies. Prerequisite knowledge and references: None

  9. Radiotherapy : the neutron therapy facility

    International Nuclear Information System (INIS)

    1991-01-01

    The neutron therapy facility at the National Accelerator Centre has operated most reliably during the period under review (July 1990 - March 1991). Apart from routine servicing, a number of repairs and developments were undertaken, inter alia: the cable to the control pedestal in the treatment vault was replaced; the proximity detector in the treatment head was repaired, and the test mode facility has been reinstated. The therapy computer system, which supervises all aspects of the operation of the treatment system, has been used dependably since the commissioning of the facility. The neutron therapy facility has been heavily utilized during the review period for calibration and research projects. Extra care has been taken to protect personnel involved in the operation of the fast neutron therapy facility, both from prompt neutron and gamma radiation and from induced activity in the equipment and in the treatment room. 3 tabs., 4 refs., 5 figs

  10. External Beam Therapy (EBT)

    Science.gov (United States)

    ... type your comment or suggestion into the following text box: Comment: E-mail: Area code: Phone no: ... Cancer Treatment Head and Neck Cancer Treatment Intensity-Modulated Radiation Therapy (IMRT) Brain ...

  11. Neutron beams for therapy

    International Nuclear Information System (INIS)

    Kuplenikov, Eh.L.; Dovbnya, A.N.; Telegin, Yu.N.; Tsymbal, V.A.; Kandybej, S.S.

    2011-01-01

    It was given the analysis and generalization of the study results carried out during some decades in many world countries on application of thermal, epithermal and fast neutrons for neutron, gamma-neutron and neutron-capture therapy. The main attention is focused on the practical application possibility of the accumulated experience for the base creation for medical research and the cancer patients effective treatment.

  12. Poster: The EURISOL Beta-beam facility

    CERN Document Server

    The beta-beam concept for the generation of an electron (anti-)neutrino beam was proposed by Piero Zucchelli (CERN) in 2002. A first study of the possibility of using the existing CERN machines for the acceleration for radioactive ions to a relativistic gamma of roughly 100, for later storage in a new decay ring of approximately the size of SPS, was made in 2002. The results from this very first short study were very encouraging.In 2004 it was decided to incorporate a design study for the beta-beam within the EURISOL DS proposal. EURISOL is a project name for a next-generation radioactive beam facility based on the ISOL method for the production of intense radioactive beams for nuclear physics, astrophysics and other applications. The proposal was accepted with the beta-beam task as an integral part. The design study officially started 1 February 2005 and will run for 4 years resulting in a conceptual design report for a beta-beam facility.

  13. Fan-beam intensity modulated proton therapy

    International Nuclear Information System (INIS)

    Hill, Patrick; Westerly, David; Mackie, Thomas

    2013-01-01

    Purpose: This paper presents a concept for a proton therapy system capable of delivering intensity modulated proton therapy using a fan beam of protons. This system would allow present and future gantry-based facilities to deliver state-of-the-art proton therapy with the greater normal tissue sparing made possible by intensity modulation techniques.Methods: A method for producing a divergent fan beam of protons using a pair of electromagnetic quadrupoles is described and particle transport through the quadrupole doublet is simulated using a commercially available software package. To manipulate the fan beam of protons, a modulation device is developed. This modulator inserts or retracts acrylic leaves of varying thickness from subsections of the fan beam. Each subsection, or beam channel, creates what effectively becomes a beam spot within the fan area. Each channel is able to provide 0–255 mm of range shift for its associated beam spot, or stop the beam and act as an intensity modulator. Results of particle transport simulations through the quadrupole system are incorporated into the MCNPX Monte Carlo transport code along with a model of the range and intensity modulation device. Several design parameters were investigated and optimized, culminating in the ability to create topotherapy treatment plans using distal-edge tracking on both phantom and patient datasets.Results: Beam transport calculations show that a pair of electromagnetic quadrupoles can be used to create a divergent fan beam of 200 MeV protons over a distance of 2.1 m. The quadrupole lengths were 30 and 48 cm, respectively, with transverse field gradients less than 20 T/m, which is within the range of water-cooled magnets for the quadrupole radii used. MCNPX simulations of topotherapy treatment plans suggest that, when using the distal edge tracking delivery method, many delivery angles are more important than insisting on narrow beam channel widths in order to obtain conformal target coverage

  14. Fan-beam intensity modulated proton therapy.

    Science.gov (United States)

    Hill, Patrick; Westerly, David; Mackie, Thomas

    2013-11-01

    This paper presents a concept for a proton therapy system capable of delivering intensity modulated proton therapy using a fan beam of protons. This system would allow present and future gantry-based facilities to deliver state-of-the-art proton therapy with the greater normal tissue sparing made possible by intensity modulation techniques. A method for producing a divergent fan beam of protons using a pair of electromagnetic quadrupoles is described and particle transport through the quadrupole doublet is simulated using a commercially available software package. To manipulate the fan beam of protons, a modulation device is developed. This modulator inserts or retracts acrylic leaves of varying thickness from subsections of the fan beam. Each subsection, or beam channel, creates what effectively becomes a beam spot within the fan area. Each channel is able to provide 0-255 mm of range shift for its associated beam spot, or stop the beam and act as an intensity modulator. Results of particle transport simulations through the quadrupole system are incorporated into the MCNPX Monte Carlo transport code along with a model of the range and intensity modulation device. Several design parameters were investigated and optimized, culminating in the ability to create topotherapy treatment plans using distal-edge tracking on both phantom and patient datasets. Beam transport calculations show that a pair of electromagnetic quadrupoles can be used to create a divergent fan beam of 200 MeV protons over a distance of 2.1 m. The quadrupole lengths were 30 and 48 cm, respectively, with transverse field gradients less than 20 T/m, which is within the range of water-cooled magnets for the quadrupole radii used. MCNPX simulations of topotherapy treatment plans suggest that, when using the distal edge tracking delivery method, many delivery angles are more important than insisting on narrow beam channel widths in order to obtain conformal target coverage. Overall, the sharp distal

  15. A reviewed technique for total body electron therapy using a Varian Clinac 2100C/D high dose rate treatment beam facility

    International Nuclear Information System (INIS)

    Oliver, L.D.; Xuereb, E.M.A.; Last, V.; Hunt, P.B.; Wilfert, A.

    1996-01-01

    Our (Royal North Shore Hospital) most recent linear accelerator acquisition is a Varian Clinac 2100C/D which has a high dose rate (approximately 25Gy per minute at 1 metre) total body electron option. We investigated the physical characteristics of the electron beam to develop a suitable method of treatment for total body electron therapy. The useful electron beam width is defined as 80cm above and below the reference height. Measurements of the electron dose received from the two angled electron beams showed a critical dependence on the gantry angles. The treatment protocol uses ten different patient angles, fractionated into directly opposing fields and treated seuqentially each day. A full cycle of treatment is completed in five days. (author)

  16. The clinical case for proton beam therapy

    International Nuclear Information System (INIS)

    Foote, Robert L; Haddock, Michael G; Yan, Elizabeth; Laack, Nadia N; Arndt, Carola A S

    2012-01-01

    Over the past 20 years, several proton beam treatment programs have been implemented throughout the United States. Increasingly, the number of new programs under development is growing. Proton beam therapy has the potential for improving tumor control and survival through dose escalation. It also has potential for reducing harm to normal organs through dose reduction. However, proton beam therapy is more costly than conventional x-ray therapy. This increased cost may be offset by improved function, improved quality of life, and reduced costs related to treating the late effects of therapy. Clinical research opportunities are abundant to determine which patients will gain the most benefit from proton beam therapy. We review the clinical case for proton beam therapy. Proton beam therapy is a technically advanced and promising form of radiation therapy

  17. The clinical case for proton beam therapy

    Directory of Open Access Journals (Sweden)

    Foote Robert L

    2012-10-01

    Full Text Available Abstract Over the past 20 years, several proton beam treatment programs have been implemented throughout the United States. Increasingly, the number of new programs under development is growing. Proton beam therapy has the potential for improving tumor control and survival through dose escalation. It also has potential for reducing harm to normal organs through dose reduction. However, proton beam therapy is more costly than conventional x-ray therapy. This increased cost may be offset by improved function, improved quality of life, and reduced costs related to treating the late effects of therapy. Clinical research opportunities are abundant to determine which patients will gain the most benefit from proton beam therapy. We review the clinical case for proton beam therapy. Summary sentence Proton beam therapy is a technically advanced and promising form of radiation therapy.

  18. Radiation therapy apparatus having retractable beam stopper

    International Nuclear Information System (INIS)

    Coad, G.L.

    1983-01-01

    This invention relates to a radiation therapy apparatus which utilized a linear translation mechanism for positioning a beam stopper. An apparatus is described wherein the beam stopper is pivotally attached to the therapy machine with an associated drive motor in such a way that the beam stopper retracts linearly

  19. Fragmentation in Carbon Therapy Beams

    CERN Document Server

    Charara, Y M

    2010-01-01

    The state of the art Monte Carlo code HETC-HEDS was used to simulate spallation products, secondary neutron, and secondary proton production in A-150 Tissue Equivalent Plastic phantoms to investigate fragmentation of carbon therapy beams. For a 356 MeV/Nucleon carbon ion beam, production of charged particles heavier than protons was 0.24 spallation products per incident carbon ion with atomic numbers ranging from 1 through 5 (hydrogen to boron). In addition, there were 4.73 neutrons and 2.95 protons produced per incident carbon ion. Furthermore, as the incident energy increases, the neutron production rate increases at a rate of 20% per 10 MeV/nucleon. Secondary protons were created at a rate between 2.62-2.87 per carbon ion, while spallation products were created at a rate between 0.20-0.24 per carbon ion.

  20. A radioactive ion beam facility using photofission

    CERN Document Server

    Diamond, W T

    1999-01-01

    Use of a high-power electron linac as the driver accelerator for a Radioactive Ion Beam (RIB) facility is proposed. An electron beam of 30 MeV and 100 kW can produce nearly 5x10 sup 1 sup 3 fissions/s from an optimized sup 2 sup 3 sup 5 U target and about 60% of this from a natural uranium target. An electron beam can be readily transmitted through a thin window at the exit of the accelerator vacuum system and transported a short distance through air to a water-cooled Bremsstrahlung-production target. The Bremsstrahlung radiation can, in turn, be transported through air to the isotope-production target. This separates the accelerator vacuum system, the Bremsstrahlung target and the isotope-production target, reducing remote handling problems. The electron beam can be scanned over a large target area to reduce the power density on both the Bremsstrahlung and isotope-production targets. These features address one of the most pressing technological challenges of a high-power RIB facility, namely the production o...

  1. Proton beam therapy control system

    Science.gov (United States)

    Baumann, Michael A [Riverside, CA; Beloussov, Alexandre V [Bernardino, CA; Bakir, Julide [Alta Loma, CA; Armon, Deganit [Redlands, CA; Olsen, Howard B [Colton, CA; Salem, Dana [Riverside, CA

    2008-07-08

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  2. Advanced Electron Beam Ion Sources (EBIS) for 2-nd generation carbon radiotherapy facilities

    CERN Document Server

    Shornikov, A.

    2016-01-01

    In this work we analyze how advanced Electron Beam Ion Sources (EBIS) can facilitate the progress of carbon therapy facilities. We will demonstrate that advanced ion sources enable operation of 2-nd generation ion beam therapy (IBT) accelerators. These new accelerator concepts with designs dedicated to IBT provide beams better suited for therapy and, are more cost efficient than contemporary IBT facilities. We will give a sort overview of the existing new IBT concepts and focus on those where ion source technology is the limiting factor. We will analyse whether this limitation can be overcome in the near future thanks to ongoing EBIS development.

  3. Partial breast radiation therapy - external beam

    Science.gov (United States)

    Carcinoma of the breast - partial radiation therapy; Partial external beam radiation - breast; Intensity-modulated radiation therapy - breast cancer; IMRT - breast cancer WBRT; Adjuvant partial breast - IMRT; APBI - IMRT; ...

  4. The basis of the particle beam therapy

    International Nuclear Information System (INIS)

    Katoh, Hiroyuki

    2015-01-01

    The particle beam therapy has the excellent physical and biological characteristics that are very different from the X-ray used mainly in conventional radiotherapy. Therefore, the particle therapy can treat loco-regional lesions more strongly with less toxicity than conventional radiotherapy. In recent years in Japan, we can use proton and carbon ion as a particle beam therapy. In this article, we describe the overview of the basis, the advantage and weak points about the particle beam therapy, and the differences between proton and carbon ion therapy. (author)

  5. A beam expander facility for studying x-ray optics

    DEFF Research Database (Denmark)

    Christensen, Finn Erland; Hornstrup, Allan; Frederiksen, P.

    1992-01-01

    The detailed study of the performance of full scale x-ray optics often requires the illumination of large areas. This paper describes a beam expander facility at the Daresbury Synchrotron Radiation Facility. It combines monochromatization and beam expansion in one dimension. The beam expansion...... x-ray telescope will be studied, is described in detail. Review of Scientific Instruments is copyrighted by The American Institute of Physics....

  6. Health physics considerations at a neutron therapy facility cyclotron

    International Nuclear Information System (INIS)

    Kleck, J.H.; Krueger, D.J.; Mc Laughlin, J.E.; Smathers, J.B.

    1987-01-01

    The U.C.L.A. Neutron Therapy Facility (NTF) is one of four such facilities in the United States currently involved in NCI sponsored trials of neutron therapy and reflects the present interest in the use of high energy neutron beams for treating certain types of human cancers. The NTF houses a CP-45 negative ion cyclotron which accelerates a 46 MeV proton beam for production of neutrons from a beryllium target. In addition to patient treatment, the NTF is involved in the production of positron emitting radioisotopes for diagnostic use in Positron Emission Tomography (PET). The activation of therapy treatment collimators, positron and neutron target systems, and a high and rapidly varying external radiation environment in a clinical setting have contributed to the need for a comprehensive radiation control program in which patient care is balanced with the maintenance of occupational exposures to ALARA levels

  7. BEAM LINE DESIGN FOR THE CERN HIRADMAT TEST FACILITY

    CERN Document Server

    Hessler, C; Goddard, B; Meddahi, M; Weterings, W

    2009-01-01

    The LHC phase II collimation project requires beam shock and impact tests of materials used for beam intercepting devices. Similar tests are also of great interest for other accelerator components such as beam entrance/exit windows and protection devices. For this purpose a dedicated High Radiation Material test facility (HiRadMat) is under study. This facility may be installed at CERN at the location of a former beam line. This paper describes the associated beam line which is foreseen to deliver a 450 GeV proton beam from the SPS with an intensity of up to 3×1013 protons per shot. Different beam line designs will be compared and the choice of the beam steering and diagnostic elements will be discussed, as well as operational issues.

  8. Beam Line Design for the CERN Hiradmat Test Facility

    CERN Document Server

    Hessler, C; Goddard, B; Meddahi, M; Weterings, W

    2010-01-01

    The LHC phase II collimation project requires beam shock and impact tests of materials used for beam intercepting devices. Similar tests are also of great interest for other accelerator components such as beam entrance/exit windows and protection devices. For this purpose a dedicated High Radiation Material test facility (HiRadMat) is under study. This facility may be installed at CERN at the location of a former beam line. This paper describes the associated beam line which is foreseen to deliver a 450 GeV proton beam from the SPS with an intensity of up to 3×10**13 protons per shot. Different beam line designs will be compared and the choice of the beam steering and diagnostic elements will be discussed, as well as operational issues.

  9. A pencil beam algorithm for helium ion beam therapy.

    Science.gov (United States)

    Fuchs, Hermann; Strobele, Julia; Schreiner, Thomas; Hirtl, Albert; Georg, Dietmar

    2012-11-01

    To develop a flexible pencil beam algorithm for helium ion beam therapy. Dose distributions were calculated using the newly developed pencil beam algorithm and validated using Monte Carlo (MC) methods. The algorithm was based on the established theory of fluence weighted elemental pencil beam (PB) kernels. Using a new real-time splitting approach, a minimization routine selects the optimal shape for each sub-beam. Dose depositions along the beam path were determined using a look-up table (LUT). Data for LUT generation were derived from MC simulations in water using GATE 6.1. For materials other than water, dose depositions were calculated by the algorithm using water-equivalent depth scaling. Lateral beam spreading caused by multiple scattering has been accounted for by implementing a non-local scattering formula developed by Gottschalk. A new nuclear correction was modelled using a Voigt function and implemented by a LUT approach. Validation simulations have been performed using a phantom filled with homogeneous materials or heterogeneous slabs of up to 3 cm. The beams were incident perpendicular to the phantoms surface with initial particle energies ranging from 50 to 250 MeV/A with a total number of 10(7) ions per beam. For comparison a special evaluation software was developed calculating the gamma indices for dose distributions. In homogeneous phantoms, maximum range deviations between PB and MC of less than 1.1% and differences in the width of the distal energy fall off of the Bragg-Peak from 80% to 20% of less than 0.1 mm were found. Heterogeneous phantoms using layered slabs satisfied a γ-index criterion of 2%/2mm of the local value except for some single voxels. For more complex phantoms using laterally arranged bone-air slabs, the γ-index criterion was exceeded in some areas giving a maximum γ-index of 1.75 and 4.9% of the voxels showed γ-index values larger than one. The calculation precision of the presented algorithm was considered to be sufficient

  10. ISOL based radioactive nuclear beam facilities

    International Nuclear Information System (INIS)

    Nomura, T.

    1991-07-01

    High-intensity and high-quality unstable nuclear beams can be realized by coupling an isotope separator on-line and a proper post accelerator in various primary beams. Some technical features and problems in the production of such beams are discussed. A brief description is given on 'Exotic Nuclei Arena' in Japanese Hadron Project. (author)

  11. Dosimetry of proton therapy beam

    International Nuclear Information System (INIS)

    Andric, S.

    1996-01-01

    Review of basic dosimetry of proton therapy treatment are presented with a goal to further development of the center for proton therapy planed in the frame of accelerator installation TESLA, which construction has been going on in the Vinca Institute. The basic of existing international recommendation for proton dosimetry, related both to dosimeter choice and calibration, as well as to absorbed dose determination methods, are presented. Recommendation statement and supposition in the future proton therapy practice belongs to the basic elements of developed conceptual program for proton therapy usage

  12. Accelerator development for a radioactive beam facility based on ATLAS

    International Nuclear Information System (INIS)

    Shepard, K. W.

    1998-01-01

    The existing superconducting linac ATLAS is in many respects an ideal secondary beam accelerator for an ISOL (Isotope separator on-line) type radioactive beam facility. Such a facility would require the addition of two major accelerator elements: a low charge state injector for the existing heavy ion linac, and a primary beam accelerator providing 220 MV of acceleration for protons and light ions. Development work for both of these elements, including the option of superconducting cavities for the primary beam accelerator is discussed

  13. Accelerator development for a radioactive beam facility based on ATLAS.

    Energy Technology Data Exchange (ETDEWEB)

    Shepard, K. W.

    1998-01-08

    The existing superconducting linac ATLAS is in many respects an ideal secondary beam accelerator for an ISOL (Isotope separator on-line) type radioactive beam facility. Such a facility would require the addition of two major accelerator elements: a low charge state injector for the existing heavy ion linac, and a primary beam accelerator providing 220 MV of acceleration for protons and light ions. Development work for both of these elements, including the option of superconducting cavities for the primary beam accelerator is discussed.

  14. Design issues of radioactive ion beam facilities

    International Nuclear Information System (INIS)

    Lieuvin, M.

    1996-01-01

    There is an increasing interest in Radioactive Ion Beams throughout the world. These ions open new domains of research for nuclear physics, nuclear astrophysics and atomic physics. Two methods are used for the production of these beams: fragmentation of a primary, high energy heavy ion beam passing through a thin target or nuclei production in a thick target bombarded either by a heavy ion beam, a proton beam or by neutrons. When radioactive species are produced in a thick target, they must be extracted, ionised, separated, identified and finally accelerated. This requires a radioactive ion source, a mass separator and a post accelerator. This paper reviews these two methods, their respective domains and the specific problems related to the control and the accelerator of radioactive ion beams. (author). 39 refs., 3 figs., 2 tabs

  15. Fan beam intensity modulated proton therapy

    Science.gov (United States)

    Hill, Patrick M.

    A fan beam proton therapy is developed which delivers intensity modulated proton therapy using distal edge tracking. The system may be retrofit onto existing proton therapy gantries without alterations to infrastructure in order to improve treatments through intensity modulation. A novel range and intensity modulation system is designed using acrylic leaves that are inserted or retracted from subsections of the fan beam. Leaf thicknesses are chosen in a base-2 system and motivated in a binary manner. Dose spots from individual beam channels range between 1 and 5 cm. Integrated collimators attempting to limit crosstalk among beam channels are investigated, but found to be inferior to uncollimated beam channel modulators. A treatment planning system performing data manipulation in MATLAB and dose calculation in MCNPX is developed. Beamlet dose is calculated on patient CT data and a fan beam source is manually defined to produce accurate results. An energy deposition tally follows the CT grid, allowing straightforward registration of dose and image data. Simulations of beam channels assume that a beam channel either delivers dose to a distal edge spot or is intensity modulated. A final calculation is performed separately to determine the deliverable dose accounting for all sources of scatter. Treatment plans investigate the effects that varying system parameters have on dose distributions. Beam channel apertures may be as large as 20 mm because the sharp distal falloff characteristic of proton dose provides sufficient intensity modulation to meet dose objectives, even in the presence of coarse lateral resolution. Dose conformity suffers only when treatments are delivered from less than 10 angles. Jaw widths of 1--2 cm produce comparable dose distributions, but a jaw width of 4 cm produces unacceptable target coverage when maintaining critical structure avoidance. Treatment time for a prostate delivery is estimated to be on the order of 10 minutes. Neutron production

  16. Cyclotron for Beam Therapy Application

    CERN Document Server

    Alenitsky, Yu G; Karamysheva, G A; Kostromin, S A; Mitsyn, G V; Molokanov, A G; Onishchenko, L M; Samsonov, E V; Vorozhtsov, S B; Zaplatin, N L

    2005-01-01

    The basic parameters of the proton isochronous cyclotron on the fixed energy are considered. The energy of protons is $E_{p}\\sim $ 220~MeV, intensity of the extracted beam is $I_{p}\\sim $ 0.1~$\\mu$A. The cyclotron is projected on the basis of compact magnet with four sectors and the diameter of poles 300 cm. Two dees of the accelerating system are located in valleys.

  17. Dose reporting in ion beam therapy. Proceedings of a meeting

    International Nuclear Information System (INIS)

    2007-06-01

    Following the pioneering work in Berkeley, USA, ion beam therapy for cancer treatment is at present offered in Chiba and Hyogo in Japan, and Darmstadt in Germany. Other facilities are coming close to completion or are at various stages of planning in Europe and Japan. In all these facilities, carbon ions have been selected as the ions of choice, at least in the first phase. Taking into account this fast development, the complicated technical and radiobiological research issues involved, and the hope it raises for some types of cancer patients, the IAEA and the International Commission on Radiation Units and measurements (ICRU) jointly sponsored a technical meeting held in Vienna, 23-24 June 2004. That first meeting was orientated mainly towards radiobiology: the relative biological effectiveness (RBE) of carbon ions versus photons, and related issues. One of the main differences between ion beam therapy and other modern radiotherapy techniques (such as proton beam therapy or intensity modulated radiation therapy) is related to radiobiology and in particular the increased RBE of carbon ions compared to both protons and photons (i.e., high linear energy transfer (LET) versus low LET radiation). Another important issue for international agencies and commissions, such as the IAEA and the ICRU, is a worldwide agreement and harmonisation for reporting the treatments. In order to evaluate the merits of ion beam therapy, it is essential that the treatments be reported in a similar/comparable way in all centres so that the clinical reports and protocols can be understood and interpreted without ambiguity by the radiation therapy community in general. For the last few decades, the ICRU has published several reports containing recommendations on how to report external photon beam or electron beam therapy, and brachytherapy. A report on proton beam therapy, jointly prepared by the ICRU and the IAEA, is now completed and is being published in the ICRU series. In line with this

  18. Review of electron beam therapy physics

    International Nuclear Information System (INIS)

    Hogstrom, Kenneth R; Almond, Peter R

    2006-01-01

    For over 50 years, electron beams have been an important modality for providing an accurate dose of radiation to superficial cancers and disease and for limiting the dose to underlying normal tissues and structures. This review looks at many of the important contributions of physics and dosimetry to the development and utilization of electron beam therapy, including electron treatment machines, dose specification and calibration, dose measurement, electron transport calculations, treatment and treatment-planning tools, and clinical utilization, including special procedures. Also, future changes in the practice of electron therapy resulting from challenges to its utilization and from potential future technology are discussed. (review)

  19. Review of electron beam therapy physics.

    Science.gov (United States)

    Hogstrom, Kenneth R; Almond, Peter R

    2006-07-07

    For over 50 years, electron beams have been an important modality for providing an accurate dose of radiation to superficial cancers and disease and for limiting the dose to underlying normal tissues and structures. This review looks at many of the important contributions of physics and dosimetry to the development and utilization of electron beam therapy, including electron treatment machines, dose specification and calibration, dose measurement, electron transport calculations, treatment and treatment-planning tools, and clinical utilization, including special procedures. Also, future changes in the practice of electron therapy resulting from challenges to its utilization and from potential future technology are discussed.

  20. ECR ion source based low energy ion beam facility

    Indian Academy of Sciences (India)

    Mass analyzed highly charged ion beams of energy ranging from a few keV to a few MeV plays an important role in various aspects of research in modern physics. In this paper a unique low energy ion beam facility (LEIBF) set up at Nuclear Science Centre (NSC) for providing low and medium energy multiply charged ion ...

  1. Extraction and beam transfer for the SHiP facility

    CERN Document Server

    Goddard, Brennan; Borburgh, Jan; Balhan, Bruno; Le Godec, Gilles; Zerlauth, Markus; Tommasini, Davide; Kain, Verena; Cornelis, Karel; Wenninger, Jorg; Jensen, Lars; Todd, Benjamin; Bauche, Jeremie; Puccio, Bruno

    2015-01-01

    This document summarises the key feasibility issues associated with the SPS extraction and beam transfer systems required for the SHiP facility. It describes the expected performance limits of the electrostatic septa, the expected beam losses during extraction and consequences, the design of the new beamline geometry and equipment systems and the expected extracted spill structure.

  2. ECR ion source based low energy ion beam facility

    Indian Academy of Sciences (India)

    Abstract. Mass analyzed highly charged ion beams of energy ranging from a few keV to a few. MeV plays an important role in various aspects of research in modern physics. In this paper a unique low energy ion beam facility (LEIBF) set up at Nuclear Science Centre (NSC) for providing low and medium energy multiply ...

  3. A Rare-Ion Beam Facility at iThemba LABS

    Science.gov (United States)

    Bark, R. A.

    2015-11-01

    iThemba LABS, chiefly based around a k=200 Separated Sector Cyclotron (SSC), is a multidisciplinary facility engaged in basic nuclear physics research, materials research, radionuclide production and hadron therapy. A proposal to acquire a new cyclotron to produce rare-ion beams for nuclear and materials research is outlined.

  4. Proton and heavy ion beam (charged particle therapy)

    International Nuclear Information System (INIS)

    Kanai, Tatsuaki

    2003-01-01

    There are distinguished therapeutic irradiation facilities of proton and heavy ion beam in Japan. The beam, due to its physical properties, is advantageous for focusing on the lesion in the body and for reducing the exposure dose to normal tissues, relative to X-ray. This makes it possible to irradiate the target lesion with the higher dose. The present review describes physical properties of the beam, equipments for the therapeutic irradiation, the respiratory-gated irradiation system, the layer-stacking irradiation system, therapy planning, and future prospect of the therapy. More than 1,400 patients have received the therapy in National Institute of Radiological Sciences (NIRS) and given a good clinical outcome. The targets are cancers of the head and neck, lung, liver, uterine and prostate, and osteosarcoma. The therapy of osteosarcoma is particularly important, which bringing about the high cure rate. Severe adverse effects are not seen with exception for the digestive tract ulcer. Many attempts like the respiratory-gated and layer-stacking systems and to shorten the therapy period to within 1 week are in progress. (N.I.)

  5. Principles and practice of proton beam therapy

    CERN Document Server

    Das, Indra J

    2015-01-01

    Commissioned by The American Association of Physicists in Medicine (AAPM) for their June 2015 Summer School, this is the first AAPM monograph printed in full color. Proton therapy has been used in radiation therapy for over 70 years, but within the last decade its use in clinics has grown exponentially. This book fills in the proton therapy gap by focusing on the physics of proton therapy, including beam production, proton interactions, biology, dosimetry, treatment planning, quality assurance, commissioning, motion management, and uncertainties. Chapters are written by the world's leading medical physicists who work at the pioneering proton treatment centers around the globe. They share their understandings after years of experience treating thousands of patients. Case studies involving specific cancer treatments show that there is some art to proton therapy as well as state-of-the-art science. Even though the focus lies on proton therapy, the content provided is also valuable to heavy charged particle th...

  6. An irradiation facility with a horizontal beam for radiobiological studies

    International Nuclear Information System (INIS)

    Czub, J.; Banas, D.; Braziewicz, J.; Choinski, J.; Jaskola, M.; Korman, A.; Szeflinski, Z.; Wojcik, A.

    2006-01-01

    A facility with a horizontal beam for radiobiological experiments with heavy ions has been designed and constructed at the Heavy Ion Laboratory in Warsaw Univ.. The facility is optimal to investigate the radiobiological effects of charged heavy particles on a cellular or molecular level as in the region of the Bragg peak. (authors)

  7. Accelerator complex for a radioactive ion beam facility at ATLAS

    International Nuclear Information System (INIS)

    Nolen, J.A.

    1995-01-01

    Since the superconducting heavy ion linac ATLAS is an ideal post-accelerator for radioactive beams, plans are being developed for expansion of the facility with the addition of a driver accelerator, a production target/ion source combination, and a low q/m pre-accelerator for radioactive ions. A working group including staff from the ANL Physics Division and current ATLAS users are preparing a radioactive beam facility proposal. The present paper reviews the specifications of the accelerators required for the facility

  8. Overview of linac applications at future radioactive beam facilities

    International Nuclear Information System (INIS)

    Nolen, Jerry A.

    1996-01-01

    There is considerable interest worldwide in the research which could be done at a next generation, advanced radioactive beam facility. To generate high quality, intense beams of accelerated radionuclides via the 'isotope separator on-line' (ISOL) method requires two major accelerator components: a high power (100 kW) driver device to produce radionuclides in a production target/ion source complex, and a secondary beam accelerator to produce beams of radioactive ions up to energies on the order of 10 MeV per nucleon over a broad mass range. In reviewing the technological challenges of such a facility, several types of modern linear accelerators appear well suited. This paper reviews the properties of the linacs currently under construction and those proposed for future facilities for use either as the driver device or the radioactive beam postaccelerator. Other choices of accelerators, such as cyclotrons, for either the driver or secondary beam devices of a radioactive beam complex will also be compared. Issues to be addressed for the production accelerator include the choice of ion beam types to be used for cost-effective production of radionuclides. For the post-accelerator the choice of ion source technology is critical and dictates the charge-to-mass requirements at the injection stage. (author)

  9. Overview of linac applications at future radioactive beam facilities

    International Nuclear Information System (INIS)

    Nolen, J.A.

    1996-01-01

    There is considerable interest worldwide in the research which could be done at a next generation, advanced radioactive beam facility. To generate high quality, intense beams of accelerated radionuclides via the open-quotes isotope separator on-lineclose quotes (ISOL) method requires two major accelerator components: a high power (100 kW) driver device to produce radionuclides in a production target/ion source complex, and a secondary beam accelerator to produce beams of radioactive ions up to energies on the order of 10 MeV per nucleon over a broad mass range. In reviewing the technological challenges of such a facility, several types of modem linear accelerators appear well suited. This paper reviews the properties of the linacs currently under construction and those proposed for future facilities for use either as the driver device or the radioactive beam post-accelerator. Other choices of accelerators, such as cyclotrons, for either the driver or secondary beam devices of a radioactive beam complex will also be compared. Issues to be addressed for the production accelerator include the choice of ion beam types to be used for cost-effective production of radionuclides. For the post-accelerator the choice of ion source technology is critical and dictates the charge-to-mass requirements at the injection stage

  10. Beam Characterization at the Neutron Radiography Facility

    Energy Technology Data Exchange (ETDEWEB)

    Sarah Morgan; Jeffrey King

    2013-01-01

    The quality of a neutron imaging beam directly impacts the quality of radiographic images produced using that beam. Fully characterizing a neutron beam, including determination of the beam’s effective length-to-diameter ratio, neutron flux profile, energy spectrum, image quality, and beam divergence, is vital for producing quality radiographic images. This project characterized the east neutron imaging beamline at the Idaho National Laboratory Neutron Radiography Reactor (NRAD). The experiments which measured the beam’s effective length-to-diameter ratio and image quality are based on American Society for Testing and Materials (ASTM) standards. An analysis of the image produced by a calibrated phantom measured the beam divergence. The energy spectrum measurements consist of a series of foil irradiations using a selection of activation foils, compared to the results produced by a Monte Carlo n-Particle (MCNP) model of the beamline. Improvement of the existing NRAD MCNP beamline model includes validation of the model’s energy spectrum and the development of enhanced image simulation methods. The image simulation methods predict the radiographic image of an object based on the foil reaction rate data obtained by placing a model of the object in front of the image plane in an MCNP beamline model.

  11. Data acquisition system for medium power neutral beam test facility

    International Nuclear Information System (INIS)

    Stewart, C.R. Jr.; Francis, J.E. Jr.; Hammons, C.E.; Dagenhart, W.K.

    1978-06-01

    The Medium Power Neutral Beam Test Facility at Oak Ridge National Laboratory was constructed in order to develop, test, and condition powerful neutral beam lines for the Princeton Large Torus experiment at Princeton Plasma Physics Laboratory. The data acquisition system for the test stand monitors source performance, beam characteristics, and power deposition profiles to determine if the beam line is operating up to its design specifications. The speed of the computer system is utilized to provide near-real-time analysis of experimental data. Analysis of the data is presented as numerical tabulation and graphic display

  12. Ion beam therapy fundamentals, technology, clinical applications

    CERN Document Server

    2012-01-01

    The book provides a detailed, up-to-date account of the basics, the technology, and the clinical use of ion beams for radiation therapy. Theoretical background, technical components, and patient treatment schemes are delineated by the leading experts that helped to develop this field from a research niche to its current highly sophisticated and powerful clinical treatment level used to the benefit of cancer patients worldwide. Rather than being a side-by-side collection of articles, this book consists of related chapters. It is a common achievement by 76 experts from around the world. Their expertise reflects the diversity of the field with radiation therapy, medical and accelerator physics, radiobiology, computer science, engineering, and health economics. The book addresses a similarly broad audience ranging from professionals that need to know more about this novel treatment modality or consider to enter the field of ion beam therapy as a researcher. However, it is also written for the interested public an...

  13. The ISOLDE Facility: Radioactive beams at CERN

    CERN Multimedia

    CERN. Geneva

    2008-01-01

    Some of the experimental techniques used will be introduced; more focus will be put on what physics questions can be answered by using radioactive beams. A brief overview is given of the present and future European developments in this rapidly evolving field. Prerequisite knowledge: none

  14. National facility for neutron beam research

    Indian Academy of Sciences (India)

    In this talk, the growth of neutron beam research (NBR) in India over the past five decades is traced beginning with research at Apsara. A range of problems in condensed matter physics could be studied at CIRUS, followed by sophisticated indegenous instrumentation and research at Dhruva. The talk ends with an overview ...

  15. Muon Beam Studies in the H4 beam line and the Gamma Irradiation Facility (GIF++)

    CERN Document Server

    Margraf, Rachel; CERN. Geneva. ATS Department

    2018-01-01

    In this note, we present detailed simulation results for the trajectory of a muon beam, traversing beam zones PPE-134 and PPE-154, produced by a 150 GeV positive hadron beam incident on collimators 9 & 10 in the H4 beam line when these collimators are placed off-beam axis to stop all hadrons and electrons. Using G4Beamline, a GEANT-4 based Monte-Carlo program, the trajectory of the muon beam has been studied for several field strengths of the GOLIATH magnet, as well as for different polarities. The position of the beam at the Gamma Irradiation Facility (GIF++), located downstream the PPE-144 area, is also presented. In addition, two configurations of the two XTDV’s present in the line (XTDV.022.520 and XTDV.022.610) have been studied, with the purpose to simulate the pion contamination of the beam both in PPE134 and GIF++.

  16. Muon Beam Studies in the H4 beam line and the Gamma Irradiation Facility (GIF++)

    CERN Document Server

    Margraf, Rachel; CERN. Geneva. EN Department

    2017-01-01

    In this report, I summarize my work of detailed study and optimization of the muon beam configuration of H4 beam line in SPS North Area. Using Monte-Carlo simulations, I studied the properties and behavior of the muon beam in combination with the field of the large, spectrometer “ GOLIATH” magnet at -1.5, -1.0, 0, 1.0 and 1.5 Tesla, which is shown to affect the central x position of the muon beam that is delivered to the Gamma Irradiation Facility (GIF++). I also studied the muon beam for different configurations of the two XTDV beam dumps upstream of GIF++ in the H4 beam line. I will also discuss my role in mapping the magnetic field of the GOLIATH magnet in the H4 beam line.

  17. The beam diagnostic instruments in Beijing radioactive ion-beam facilities isotope separator on-line

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Y., E-mail: yjma@ciae.ac.cn; Cui, B.; Ma, R.; Tang, B.; Chen, L.; Huang, Q.; Jiang, W. [China Institute of Atomic Energy, Beijing 102413 (China)

    2014-02-15

    The beam diagnostic instruments for Beijing Radioactive Ion-beam Facilities Isotope Separator On-Line are introduced [B. Q. Cui, Z. H. Peng, Y. J. Ma, R. G. Ma, B. Tang, T. Zhang, and W. S. Jiang, Nucl. Instrum. Methods 266, 4113 (2008); T. J. Zhang, X. L. Guan, and B. Q. Cui, in Proceedings of APAC 2004, Gyeongju, Korea, 2004, http://www.jacow.org , p. 267]. For low intensity ion beam [30–300 keV/1 pA–10 μA], the beam profile monitor, the emittance measurement unit, and the analyzing slit will be installed. For the primary proton beam [100 MeV/200 μA], the beam profile scanner will be installed. For identification of the nuclide, a beam identification unit will be installed. The details of prototype of the beam diagnostic units and some experiment results will be described in this article.

  18. The beam diagnostic instruments in Beijing radioactive ion-beam facilities isotope separator on-line

    Science.gov (United States)

    Ma, Y.; Cui, B.; Ma, R.; Tang, B.; Chen, L.; Huang, Q.; Jiang, W.

    2014-02-01

    The beam diagnostic instruments for Beijing Radioactive Ion-beam Facilities Isotope Separator On-Line are introduced [B. Q. Cui, Z. H. Peng, Y. J. Ma, R. G. Ma, B. Tang, T. Zhang, and W. S. Jiang, Nucl. Instrum. Methods 266, 4113 (2008); T. J. Zhang, X. L. Guan, and B. Q. Cui, in Proceedings of APAC 2004, Gyeongju, Korea, 2004, http://www.jacow.org, p. 267]. For low intensity ion beam [30-300 keV/1 pA-10 μA], the beam profile monitor, the emittance measurement unit, and the analyzing slit will be installed. For the primary proton beam [100 MeV/200 μA], the beam profile scanner will be installed. For identification of the nuclide, a beam identification unit will be installed. The details of prototype of the beam diagnostic units and some experiment results will be described in this article.

  19. The Swedish facility for boron neutron capture therapy

    International Nuclear Information System (INIS)

    Skoeld, K.; Capala, J.; Kierkegaard, J.; Haakansson, R.; Gudowska, I.

    2000-01-01

    A BNCT (Boron Neutron Capture Therapy) facility has been constructed at the R2-0 reactor at Studsvik, Sweden. R2-0 is a 1 MW, open core, pool reactor. The reactor core is suspended on a movable tower and can be positioned anywhere in the pool. The BNCT facility includes two adjacent, parallel filter/moderator configurations and the reactor core is positioned in front of any of them as appropriate. One of the resulting neutron beams has been optimized for clinical irradiations with a filter/moderator system that allows easy variation of the neutron spectrum from the thermal to the epithermal energy range and with an extended collimator for convenient patient positioning. The other beam has been designed for radiobiological research and is equipped with a heavy water moderator and a large irradiation cavity with a uniform field of thermal neutrons. (author)

  20. Microdosimetric investigations at the fast neutron therapy facility at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Langen, K.M.

    1997-12-01

    Microdosimetry was used to investigate three issues at the neutron therapy facility (NTF) at Fermilab. Firstly, the conversion factor from absorbed dose in A-150 tissue equivalent plastic to absorbed dose in ICRU tissue was determined. For this, the effective neutron kerma factor ratios, i.e., oxygen tissue equivalent plastic and carbon to A-150 tissue equivalent plastic, were measured in the neutron beam. An A-150 tissue equivalent plastic to ICRU tissue absorbed dose conversion factor of 0.92 {+-} 0.04 was determined. Secondly, variations in the radiobiological effectiveness (RBE) in the beam were mapped by determining variations in two related quantities, e{sup *} and R, with field size and depth in tissue. Maximal variation in e{sup *} and R of 9% and 15% respectively were determined. Lastly, the feasibility of utilizing the boron neutron capture reaction on boron-10 to selectively enhance the tumor dose in the NTF beam was investigated.

  1. Microdosimetric investigations at the fast neutron therapy facility at Fermilab

    International Nuclear Information System (INIS)

    Langen, K.M.

    1997-01-01

    Microdosimetry was used to investigate three issues at the neutron therapy facility (NTF) at Fermilab. Firstly, the conversion factor from absorbed dose in A-150 tissue equivalent plastic to absorbed dose in ICRU tissue was determined. For this, the effective neutron kerma factor ratios, i.e., oxygen tissue equivalent plastic and carbon to A-150 tissue equivalent plastic, were measured in the neutron beam. An A-150 tissue equivalent plastic to ICRU tissue absorbed dose conversion factor of 0.92 ± 0.04 was determined. Secondly, variations in the radiobiological effectiveness (RBE) in the beam were mapped by determining variations in two related quantities, e * and R, with field size and depth in tissue. Maximal variation in e * and R of 9% and 15% respectively were determined. Lastly, the feasibility of utilizing the boron neutron capture reaction on boron-10 to selectively enhance the tumor dose in the NTF beam was investigated

  2. Repeated proton beam therapy for hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Hashimoto, Takayuki; Tokuuye, Koichi; Fukumitsu, Nobuyoshi; Igaki, Hiroshi; Hata, Masaharu; Kagei, Kenji; Sugahara, Shinji; Ohara, Kiyoshi; Matsuzaki, Yasushi; Akine, Yasuyuki

    2006-01-01

    Purpose: To retrospectively evaluate the safety and effectiveness of repeated proton beam therapy for newly developed or recurrent hepatocellular carcinoma (HCC). Methods and Materials: From June 1989 through July 2000, 225 patients with HCC underwent their first course of proton beam therapy at University of Tsukuba. Of them, 27 with 68 lesions who had undergone two or more courses were retrospectively reviewed in this study. Median interval between the first and second course was 24.5 months (range 3.3-79.8 months). Median total dose of 72 Gy in 16 fractions and 66 Gy in 16 fractions were given for the first course and the rest of the courses, respectively. Results: The 5-year survival rate and median survival period from the beginning of the first course for the 27 patients were 55.6% and 62.2 months, respectively. Five-year local control rate for the 68 lesions was 87.8%. Of the patients, 1 with Child-Pugh class B and another with class C before the last course suffered from acute hepatic failure. Conclusions: Repeated proton beam therapy for HCC is safe when the patient has a target in the peripheral region of the liver and liver function is Child-Pugh class A

  3. The SPES Radioactive-Ion Beam Facility of INFN

    Science.gov (United States)

    de Angelis, G.; Prete, G.; Andrighetto, A.; Manzolaro, M.; Corradetti, S.; Scarpa, D.; Rossignoli, M.; Monetti, A.; Lollo, M.; Calderolla, M.; Vasquez, J.; Zafiropoulos, D.; Sarchiapone, L.; Benini, D.; Favaron, P.; Rigato, M.; Pegoraro, R.; Maniero, D.; Comunian, M.; Maggiore, M.; Lombardi, A.; Piazza, L.; Porcellato, A. M.; Roncolato, C.; Bisoffi, G.; Pisent, A.; Galatà, A.; Giacchini, M.; Bassato, G.; Canella, S.; Gramegna, F.; Valiente, J.; Bermudez, J.; Mastinu, P. F.; Esposito, J.; Wyss, J.; Russo, A.; Zanella, S.; Calabretta, L.

    2015-11-01

    A new radioactive-ion beam (RIB) facility (SPES) is presently under construction at the Legnaro National Laboratories of INFN. The SPES facility is based on the ISOL method using a UCx direct target able to sustain a power of 10 kW. The primary proton beam will be provided by a high-current cyclotron accelerator with energy of 35-70 MeV and a beam current of 0.2-0.5 mA. Neutron-rich radioactive ions will be produced by proton-induced fission on a uranium target at an expected fission rate of the order of 1013 fissions per second. After ionization and selection the exotic isotopes will be re-accelerated by the ALPI superconducting LINAC at energies of 10A MeV for masses in the region A=130 amu. The expected secondary beam rates are of the order of 107-109 pps. The aim of the SPES facility is to deliver high-intensity radioactive-ion beams of neutron-rich nuclei for nuclear physics research, as well as to be an interdisciplinary research center for radioisotope production for medicine and for neutron beams.

  4. The SPES Radioactive Ion Beam facility of INFN

    Science.gov (United States)

    de Angelis, G.; Spes Collaboration; Prete, G.; Andrighetto, A.; Manzolaro, M.; Corradetti, S.; Scarpa, D.; Rossignoli, M.; Monetti, A.; Lollo, M.; Calderolla, M.; Vasquez, J.; Zafiropoulos, D.; Sarchiapone, L.; Benini, D.; Favaron, P.; Rigato, M.; Pegoraro, R.; Maniero, D.; Calabretta, L.; Comunian, M.; Maggiore, M.; Lombardi, A.; Piazza, L.; Porcellato, A. M.; Roncolato, C.; Bisoffi, G.; Pisent, A.; Galatà, A.; Giacchini, M.; Bassato, G.; Canella, S.; Gramegna, F.; Valiente, J.; Bermudez, J.; Mastinu, P. F.; Esposito, J.; Wyss, J.; Russo, A.; Zanella, S.

    2015-02-01

    A new Radioactive Ion Beam (RIB) facility (SPES) is presently under construction at the Legnaro National Laboratories of INFN. The SPES facility is based on the ISOL method using an UCx Direct Target able to sustain a power of 10 kW. The primary proton beam is provided by a high current Cyclotron accelerator with energy of 40 MeV and a beam current of 0.2-0.5 mA. Neutron-rich radioactive ions are produced by proton induced fission at an expected fission rate of the order of 1013 fissions per second. After ionization and selection the exotic isotopes are re-accelerated by the ALPI superconducting LINAC at energies of 10A MeV for masses in the region A=130 amu. The expected secondary beam rates are of the order of 107 - 109 pps. Aim of the SPES facility is to deliver high intensity radioactive ion beams of neutron rich nuclei for nuclear physics research as well as to be an interdisciplinary research center for radio-isotopes production for medicine and for neutron beams.

  5. E-beam transportation features in GOL-3 facility

    International Nuclear Information System (INIS)

    Arzhannikov, A.V.; Astrelin, V.T.; Averkov, A.M.

    2005-01-01

    Results on transportation of the high-current relativistic electron beam (1 MeV, 40 kA, 8 μs) through the 17-m-long channel with magnetic field on GOL-3 facility are presented. The beam is formed in the ribbon diode and then it is injected into the 12-meter plasma column of the multimirror trap GOL-3. Dynamics of the beam and plasma currents, which results in formation of radial structure of helical magnetic field, is described [ru

  6. CERN accelerator school: Antiprotons for colliding beam facilities

    International Nuclear Information System (INIS)

    Bryant, P.; Newman, S.

    1984-01-01

    This is a specialized course which addresses a wide spectrum of theoretical and technological problems confronting the designer of an antiproton facility for high-energy-physics research. A broad and profound basis is provided by the lecturers' substantial experience gained over many years with CERN's unique equipment. Topics include beam optics, special lattices for antiproton accumulation and storage rings, antiproton production, stochastic cooling, acceleration and storage, r.f. noise, r.f. beam manipulations, beam-beam interaction, beam stability due to ion accumulation, and diagnostics. The SPS (Super Proton Synchrotron) panti p collider, LEAR (the Low Energy Antiproton Ring at CERN), antiprotons in the ISR (Intersecting Storage Rings), the new antiproton collector (ACOL) and gas jet targets are also discussed. A table is included listing the parameters of all CERN's accelerators and storage rings. See hints under the relevant topics. (orig./HSI)

  7. Beam generation at next generation RIB facilities: conceptual design studies

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Y.; Alton, G.D. [Physics Division, Oak Ridge National Laboratory, Oak Ridge, TN (United States)

    2004-12-27

    In order to produce useful intensities of radioactive ion beams, ISOL targets must be designed that can withstand direct irradiation with high power beams. Computational thermal modeling techniques offer a cost effective way for evaluating prototype target concepts in the quest to find an optimum design. In this report, a number of codes are utilized to select target materials and to model the primary beam power density, thermal transport and temperature distributions in ISOL targets. These studies suggest that radiation cooling, in combination with Lissajous beam scan techniques, can be used to control temperatures in practically sized targets, to levels commensurate with irradiation with 1-GeV, 400-kW proton beams for next generation RIB facilities.

  8. Radionuclide therapy practice and facilities in Europe

    International Nuclear Information System (INIS)

    Hoefnagel, C.A.; Clarke, S.E.M.; Fischer, M.; Chatal, J.F.; Lewington, V.J.; Nilsson, S.; Troncone, L.; Vieira, M.R.

    1999-01-01

    Using a questionnaire the EANM Task Group Radionuclide Therapy in 1993 collected data on the current practice of radionuclide therapy in European countries. Subsequently, at the request of the EANM Executive Committee, the EANM Radionuclide Therapy Committee has made an inventory of the distribution of facilities for radionuclide therapy and undertaken an assessment of the total number of patients treated throughout Europe and of the types of treatment provides, with the aim of supporting the development of policy to adjust the available capacity to the needs by the year 2000. For this purpose, a second, more detailed questionnaire was sent out the members and national advisors of the Committee (see below), who gathered the data for each country that was a member of the EANM at the time. It is concluded that a wide bariation in therapy practice exists across Europe, particularly in the utilisation of radionuclide therapy, the requirement and availability of proper isolation facilities and the background training of those undertaking therapy. More uniform guidelines and legislation are required, although changes in legislation may have a significant impact in some countries. Although there is wide variation in the therapies used in each country, one the whole it appears that there is an underutilisation of nuclear medicine as a therapeutic modality. A rapidly increasing role may be expected, in particular for oncological indications requiring high-dose radionuclide treatment. Therefore there is an urgent need for a greater number of isolation beds in dedicated centers throughout Europe

  9. Radionuclide therapy practice and facilities in Europe

    Energy Technology Data Exchange (ETDEWEB)

    Hoefnagel, C.A.; Clarke, S.E.M.; Fischer, M.; Chatal, J.F.; Lewington, V.J.; Nilsson, S.; Troncone, L.; Vieira, M.R.

    1999-03-01

    Using a questionnaire the EANM Task Group Radionuclide Therapy in 1993 collected data on the current practice of radionuclide therapy in European countries. Subsequently, at the request of the EANM Executive Committee, the EANM Radionuclide Therapy Committee has made an inventory of the distribution of facilities for radionuclide therapy and undertaken an assessment of the total number of patients treated throughout Europe and of the types of treatment provides, with the aim of supporting the development of policy to adjust the available capacity to the needs by the year 2000. For this purpose, a second, more detailed questionnaire was sent out the members and national advisors of the Committee (see below), who gathered the data for each country that was a member of the EANM at the time. It is concluded that a wide bariation in therapy practice exists across Europe, particularly in the utilisation of radionuclide therapy, the requirement and avilability of proper isolation facilities and the background training of those undertaking therapy. More uniform guidelines and legislation are required, although changes in legislation may have a significant impact in some countries. Although there is wide variation in the therapies used in each country, one the whole it appears that there is an underutilisation of nuclear medicine as a therapeutic modality. A rapidly increasing role may be expected, in particular for oncological indications requiring high-dose radionuclide treatment. Therefore there is an urgent need for a greater number of isolation beds in dedicated centers throughout Europe. With 8 tabs.

  10. Prospects for high-power radioactive beam facilities worldwide

    CERN Document Server

    Nolen, Jerry A

    2003-01-01

    Advances in accelerators, targets, ion sources, and experimental instrumentation are making possible ever more powerful facilities for basic and applied research with short-lived radioactive isotopes. There are several current generation facilities, based on a variety of technologies, operating worldwide. These include, for example, those based on the in-flight method such as the recently upgraded National Superconducting Cyclotron Laboratory at Michigan State University, the facility at RIKEN in Japan, GANIL in Caen, France, and GSI in Darmstadt, Germany. Present facilities based on the Isotope-Separator On-Line method include, for example, the ISOLDE laboratory at CERN, HRIBF at Oak Ridge, and the new high-power facility ISAC at TRIUMF in Vancouver. Next-generation facilities include the Radioactive-Ion Factory upgrade of RIKEN to higher energy and intensity and the upgrade of ISAC to a higher energy secondary beam; both of these projects are in progress. A new project, LINAG, to upgrade the capabilities at...

  11. Upgrading the AGS polarized beam facility

    International Nuclear Information System (INIS)

    Ratner, L.G.

    1991-01-01

    Although present techniques for crossing depolarizing resonances in circular accelerators work, they are very time-consuming to implement and were only able to provide about a 40% polarized beam at 22 GeV in the Alternating Gradient Synchrotron (AGS). We propose to install a partial ''Siberian Snake'' solenoid in the AGS to eliminate the need to correct imperfection resonances and to make other modifications in our intrinsic resonance correctors. This will allow us to reach an energy of 25 GeV with 70% polarization and will enable the AGS to be an efficient injector of polarized protons into the Relativistic Heavy Ion Collider (RHIC), as well as being able to carry on a fixed-target program with minimum set-up time. 3 refs., 5 figs., 1 tab

  12. Neutron field characterization and dosimetry at the TRIUMF proton therapy facility

    International Nuclear Information System (INIS)

    Mukherjee, B.

    2002-01-01

    Full text: In 1972 the 500 MeV H' Cyclotron of the TRIUMF (Tri University Meson Factory) located in Vancouver, Canada became operational. Beside Meson Physics, high-energy protons of various energy and beam current levels from the TRIUMF Cyclotron are used for scientific research and biomedical applications. Recently, a 500 MeV proton beam from the cyclotron was used as the booster beam for the radioactive ion beam facility, ISAC (Isotope Separator Accelerator) and a second beam as primary irradiation source for the Proton Irradiation Facility (PIF). The major commercial applications of the PIF are the provision of high-energy proton beams for radiation hardness testing of electronic components used in space applications (NASA) and proton therapy of ocular tumors (British Columbia Proton Therapy Facility). The PIF vault was constructed within the main accelerator hall of the TRIUMF using stacks of large concrete blocks. An intense field of fast neutrons is produced during the interaction of high-energy proton beam with target materials, such as, beam stops, collimators and beam energy degraders. The leakage of such neutrons due to insufficient radiological shielding or through the shielding discontinuities may constitute a major share of the personnel radiation exposure of the radiation workers. The neutron energy distribution and dose equivalent near a lead beam stopper bombarded with 116 MeV and 65 MeV collimated proton beams at the Ocular Tumor irradiation facility were evaluated using a Bonner-Sphere Spectrometer and a REM counter respectively. The results were utilized to investigate efficacy of the existing radiological shielding of the PIF. This paper highlights experimental methods to analyze the high-energy accelerator produced neutron beam and basic guideline for the radiological shielding designs of irradiation vault of Proton Therapy facilities

  13. Proton therapy detector studies under the experience gained at the CATANA facility

    International Nuclear Information System (INIS)

    Cuttone, G.; Cirrone, G.A.P.; Di Rosa, F.; Lojacono, P.A.; Lo Nigro, S.; Marino, C.; Mongelli, V.; Patti, I.V.; Pittera, S.; Raffaele, L.; Russo, G.; Sabini, M.G.; Salamone, V.; Valastro, L.M.

    2007-01-01

    Proton therapy represents the most promising radiotherapy technique for external tumor treatments. At Laboratori Nazionali del Sud of the Istituto Nazionale di Fisica Nucleare (INFN-LNS), Catania (I), a proton therapy facility is active since March 2002 and 140 patients, mainly affected by choroidal and iris melanoma, have been successfully treated. Proton beams are characterized by higher dose gradients and linear energy transfer with respect to the conventional photon and electron beams, commonly used in medical centers for radiotherapy. In this paper, we report the experience gained in the characterization of different dosimetric systems, studied and/or developed during the last ten years in our proton therapy facility

  14. Neutron beam facilities at the Replacement Research Reactor, ANSTO

    International Nuclear Information System (INIS)

    Kim, S.

    2003-01-01

    The exciting development for Australia is the construction of a modern state-of-the-art 20-MW Replacement Research Reactor which is currently under construction to replace the aging reactor (HIFAR) at ANSTO in 2006. To cater for advanced scientific applications, the replacement reactor will provide not only thermal neutron beams but also a modern cold-neutron source moderated by liquid deuterium at approximately -250 deg C, complete with provision for installation of a hot-neutron source at a later stage. The latest 'supermirror' guides will be used to transport the neutrons to the Reactor Hall and its adjoining Neutron Guide Hall where a suite of neutron beam instruments will be installed. These new facilities will expand and enhance ANSTO's capabilities and performance in neutron beam science compared with what is possible with the existing HIFAR facilities, and will make ANSTO/Australia competitive with the best neutron facilities in the world. Eight 'leading-edge' neutron beam instruments are planned for the Replacement Research Reactor when it goes critical in 2006, followed by more instruments by 2010 and beyond. Up to 18 neutron beam instruments can be accommodated at the Replacement Research Reactor, however, it has the capacity for further expansion, including potential for a second Neutron Guide Hall. The first batch of eight instruments has been carefully selected in conjunction with a user group representing various scientific interests in Australia. A team of scientists, engineers, drafting officers and technicians has been assembled to carry out the Neutron Beam Instrument Project to successful completion. Today, most of the planned instruments have conceptual designs and are now being engineered in detail prior to construction and procurement. A suite of ancillary equipment will also be provided to enable scientific experiments at different temperatures, pressures and magnetic fields. This paper describes the Neutron Beam Instrument Project and gives

  15. The radioactive ion beams facility in Brazil RIBRAS

    Energy Technology Data Exchange (ETDEWEB)

    Lichtenthaler, R. [Instituto de Fisica, Universidade de Sao Paulo, C.P. 66318, 05389-970 Sao Paulo (Brazil)

    2007-12-15

    A double superconducting solenoid system is installed at the Pelletron Laboratory of the University of Sao Paulo, Brazil. This system allows the production of secondary beams of {sup 8}Li, {sup 6}He, {sup 7}Be and other light exotic nuclei. The first results using this facility are presented. (Author)

  16. Fermilab Test Beam Facility Annual Report. FY 2014

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States). et al.

    2015-01-01

    Fermilab Test Beam Facility (FTBF) operations are summarized for FY 2014. It is one of a series of publications intended to gather information in one place. In this case, the information concerns the individual experiments that ran at FTBF. Each experiment section was prepared by the relevant authors, and was edited for inclusion in this summary.

  17. The neutron beam facility at the Australian replacement research reactor

    International Nuclear Information System (INIS)

    Hunter, B.; Kennedy, S.

    1999-01-01

    Full text: The Australian federal government gave ANSTO final approval to build a research reactor to replace HIFAR on August 25th 1999. The replacement reactor is to be a multipurpose reactor with a thermal neutron flux of 3 x 10 14 n.cm -2 .s -1 and having improved capabilities for neutron beam research and for the production of radioisotopes for pharmaceutical, scientific and industrial use. The replacement reactor will commence operation in 2005 and will cater for Australian scientific, industrial and medical needs well into the 21st century. The scientific capabilities of the neutron beams at the replacement reactor are being developed in consultation with representatives from academia, industry and government research laboratories to provide a facility for condensed matter research in physics, chemistry, materials science, life sciences, engineering and earth sciences. Cold, thermal and hot neutron sources are to be installed, and neutron guides will be used to position most of the neutron beam instruments in a neutron guide hall outside the reactor confinement building. Eight instruments are planned for 2005, with a further three to be developed by 2010. A conceptual layout for the neutron beam facility is presented including the location of the planned suite of neutron beam instruments. The reactor and all the associated infrastructure, with the exception of the neutron beam instruments, is to be built by an accredited reactor builder in a turnkey contract. Tenders have been called for December 1999, with selection of contractor planned by June 2000. The neutron beam instruments will be developed by ANSTO and other contracted organisations in consultation with the user community and interested overseas scientists. The facility will be based, as far as possible, around a neutron guide hall that is be served by three thermal and three cold neutron guides. Efficient transportation of thermal and cold neutrons to the guide hall requires the use of modern super

  18. Quantitative analysis of beam delivery parameters and treatment process time for proton beam therapy

    International Nuclear Information System (INIS)

    Suzuki, Kazumichi; Gillin, Michael T.; Sahoo, Narayan; Zhu, X. Ronald; Lee, Andrew K.; Lippy, Denise

    2011-01-01

    Purpose: To evaluate patient census, equipment clinical availability, maximum daily treatment capacity, use factor for major beam delivery parameters, and treatment process time for actual treatments delivered by proton therapy systems. Methods: The authors have been recording all beam delivery parameters, including delivered dose, energy, range, spread-out Bragg peak widths, gantry angles, and couch angles for every treatment field in an electronic medical record system. We analyzed delivery system downtimes that had been recorded for every equipment failure and associated incidents. These data were used to evaluate the use factor of beam delivery parameters, the size of the patient census, and the equipment clinical availability of the facility. The duration of each treatment session from patient walk-in and to patient walk-out of the treatment room was measured for 82 patients with cancers at various sites. Results: The yearly average equipment clinical availability in the last 3 yrs (June 2007-August 2010) was 97%, which exceeded the target of 95%. Approximately 2200 patients had been treated as of August 2010. The major disease sites were genitourinary (49%), thoracic (25%), central nervous system (22%), and gastrointestinal (2%). Beams have been delivered in approximately 8300 treatment fields. The use factor for six beam delivery parameters was also evaluated. Analysis of the treatment process times indicated that approximately 80% of this time was spent for patient and equipment setup. The other 20% was spent waiting for beam delivery and beam on. The total treatment process time can be expressed by a quadratic polynomial of the number of fields per session. The maximum daily treatment capacity of our facility using the current treatment processes was estimated to be 133 ± 35 patients. Conclusions: This analysis shows that the facility has operated at a high performance level and has treated a large number of patients with a variety of diseases. The use

  19. Developing of the protocol for electron beam food irradiation facility

    International Nuclear Information System (INIS)

    Petreska, Svetlana

    2012-01-01

    By establishing the needs for institution of new technologies in the process of food processing, in this case a randomized choice of electron beam accelerator facility, arises the need for designing a protocol for safe and secure performance of the facility. The protocol encompasses safety and security measures for protection from ionizing radiation of the individuals who work at the facility, as well as, the population and the environment in the immediate neighborhood of the facility. Thus, the adopted approach is the establishment of appropriate systems responding to the protocol. Dosimetry system, which includes appropriate procedures for accurate measure and recording of the absorbed dose values, according to the provisions for protection from ionizing radiation. Ionizing radiation protection system and providing the safety and security of the facility for food processing by means of ionizing radiation. System for providing quality and safety control of the facility for food processing by means of ionizing radiation. Pursuant to the designed a protocol for safe and secure performance of the facility for electron beam food processing, contributes to protection against ionizing radiation as occupationally exposed persons as well the population. (Author)

  20. Defocusing beam line design for an irradiation facility at the TAEA SANAEM Proton Accelerator Facility

    CERN Document Server

    Gencer, A.; Efthymiopoulos, I.; Yiğitoğlu, M.

    2016-01-01

    Electronic components must be tested to ensure reliable performance in high radiation environments such as Hi-Limu LHC and space. We propose a defocusing beam line to perform proton irradiation tests in Turkey. The Turkish Atomic Energy Authority SANAEM Proton Accelerator Facility was inaugurated in May 2012 for radioisotope production. The facility has also an R&D room for research purposes. The accelerator produces protons with 30 MeV kinetic energy and the beam current is variable between View the MathML source10μA and View the MathML source1.2mA. The beam kinetic energy is suitable for irradiation tests, however the beam current is high and therefore the flux must be lowered. We plan to build a defocusing beam line (DBL) in order to enlarge the beam size, reduce the flux to match the required specifications for the irradiation tests. Current design includes the beam transport and the final focusing magnets to blow up the beam. Scattering foils and a collimator is placed for the reduction of the beam ...

  1. Neutron beam facilities at the replacement research reactor

    International Nuclear Information System (INIS)

    Kennedy, S.

    1999-01-01

    Full text: On September 3rd 1997 the Australian Federal Government announced their decision to replace the HIFAR research reactor by 2005. The proposed reactor will be a multipurpose reactor with improved capabilities for neutron beam research and for the production of radioisotopes for pharmaceutical, scientific and industrial use. The neutron beam facilities are intended to cater for Australian scientific needs well into the 21st century. In the first stage of planning the neutron Beam Facilities at the replacement reactor, a Consultative Group was formed (BFCG) to determine the scientific capabilities of the new facility. Members of the group were drawn from academia, industry and government research laboratories. The BFCG submitted their report in April 1998, outlining the scientific priorities to be addressed. Cold and hot neutron sources are to be included, and cold and thermal neutron guides will be used to position most of the instruments in a neutron guide hall outside the reactor confinement building. In 2005 it is planned to have eight instruments installed with a further three to be developed by 2010, and seven spare instrument positions for development of new instruments over the life of the reactor. A beam facilities technical group (BFTG) was then formed to prepare the engineering specifications for the tendering process. The group consisted of some members of the BFCG, several scientists and engineers from ANSTO, and scientists from leading neutron scattering centres in Europe, USA and Japan. The BFTG looked in detail at the key components of the facility such as the thermal, cold and hot neutron sources, neutron collimators, neutron beam guides and overall requirements for the neutron guide hall. The report of the BFTG, completed in August 1998, was incorporated into the draft specifications for the reactor project, which were distributed to potential reactor vendors. An assessment of the first stage of reactor vendor submissions was completed in

  2. Muon-decay medium-baseline neutrino beam facility

    Directory of Open Access Journals (Sweden)

    Jun Cao

    2014-09-01

    Full Text Available Neutrino beam with about 300 MeV in energy, high-flux and medium baseline is considered a rational choice for measuring CP violation before the more powerful Neutrino Factory is to be built. Following this concept, a unique neutrino beam facility based on muon-decayed neutrinos is proposed. The facility adopts a continuous-wave proton linac of 1.5 GeV and 10 mA as the proton driver, which can deliver an extremely high beam power of 15 MW. Instead of pion-decayed neutrinos, unprecedentedly intense muon-decayed neutrinos are used for better background discrimination. The schematic design for the facility is presented here, including the proton driver, the assembly of a mercury-jet target and capture superconducting solenoids, a pion/muon beam transport line, a long muon decay channel of about 600 m and the detector concept. The physics prospects and the technical challenges are also discussed.

  3. Broad-beam, high current, metal ion implantation facility

    International Nuclear Information System (INIS)

    Brown, I.G.; Dickinson, M.R.; Galvin, J.E.; Godechot, X.; MacGill, R.A.

    1990-07-01

    We have developed a high current metal ion implantation facility with which high current beams of virtually all the solid metals of the Periodic Table can be produced. The facility makes use of a metal vapor vacuum arc ion source which is operated in a pulsed mode, with pulse width 0.25 ms and repetition rate up to 100 pps. Beam extraction voltage is up to 100 kV, corresponding to an ion energy of up to several hundred keV because of the ion charge state multiplicity; beam current is up to several Amperes peak and around 10 mA time averaged delivered onto target. Implantation is done in a broad-beam mode, with a direct line-of-sight from ion source to target. Here we describe the facility and some of the implants that have been carried out using it, including the 'seeding' of silicon wafers prior to CVD with titanium, palladium or tungsten, the formation of buried iridium silicide layers, and actinide (uranium and thorium) doping of III-V compounds. 16 refs., 6 figs

  4. Progress in neutron beam development at the HFR Petten (feasibility study for a BNCT facility)

    International Nuclear Information System (INIS)

    Constantine, G.; Moss, R.L.; Watkins, P.R.D.; Perks, C.A.; Delafield, H.J.; Ross, D.; Voorbraak, W.P.; Paardekooper, A.; Freudenreich, W.E.; Stecher-Rasmussen, F.

    1990-08-01

    Boron Neutron Capture Therapy, using intermediate energy neutrons to achieve the deep penetration essential for treating brain tumours, can be implemented with a filtered reactor neutron beam. This is designed to minimize the mean energy of the neutrons to keep proton recoil damage to the scalp within normal tissue tolerance limits whilst delivering the required thermal neutron fluence to the tumour over a reasonably short period. This can only be realized in conjunction with a high power density reactor. At the Joint Research Centre Petten an optimized neutron filter is currently being built for installation into the HB11 beam tube of the High Flux Reactor HFR. Part of the development leading to this design has been an extensive study of broad spectrum, filtered beam performance on the HB7 beam tube facility. A wide range of calculations was performed using the Monte Carlo code, MCPN, supported by validation experiments in which several filter configuration incorporating aluminium, sulphur, liquid argon, titanium and cadmium were installed for low power measurements of the neutron fluence rate, neutron spectra and beam gamma-ray contamination. The measurements were carried out within a successful European collaboration. Evaluations were made of the reactor core edge and unfiltered beam spectra, for comparison with MCNP calculations. Multi-foil activation methods and also gamma dose determination in the filtered beam using thermo-luminescent detectors were performed by the ECN. The Harwell/ Birmingham University collaborators undertook the neutron spectrum measurements in the filtered beam. proton recoil spectrometry was used above 30 keV, combined with a multi-sphere and BF 3 chamber response modification technique. Subsequent spectrum adjustment was carried out with the SENSAK code. The agreement between the calculated and measured spectra has given confidence in the reactor and filter modelling methods used to design the HB11 therapy facility. (author). 12 refs

  5. CEBAF [Continuous Electron Beam Accelerator Facility] design report

    International Nuclear Information System (INIS)

    1986-05-01

    This book describes the conceptual design of, and the planning for, the Continuous Electron Beam Accelerator Facility (CEBAF), which will be a high-intensity, continuous-wave electron linear accelerator (linac) for nuclear physics. Its principal scientific goal is to understand the quark structure, behavior, and clustering of individual nucleons in the nuclear medium, and simultaneously to understand the forces governing this behavior. The linac will consist of 1 GeV of accelerating structure, split into two antiparallel 0.5-GeV segments. The segments will be connected by a beam transport system to circulate the electron beams from one segment to the other for up to four complete passes of acceleration. The maximum beam energy will be 4 GeV at a design current of 200 microamperes. The accelerator complex will also include systems to extract three continuous beams from the linac and to deliver them to three experimental halls equipped with detectors and instrumentation for nuclear physics research. The accelerating structure will be kept superconducting within insulated cryostats filled with liquid helium produced at a central helium refrigerator and distributed to the cryostats via insulated transfer lines. An injector, instrumentation and controls for the accelerator, radio-frequency power systems, and several support facilities will also be provided. A cost estimate based on the Work Breakdown Structure has been completed. Assuming a five-year construction schedule starting early in FY 1987, the total estimated cost is $236 million (actual year dollars), including contingency

  6. Development and Commissioning of an External Beam Facility in the Union College Ion Beam Analysis Laboratory

    Science.gov (United States)

    Yoskowitz, Joshua; Clark, Morgan; Labrake, Scott; Vineyard, Michael

    2015-10-01

    We have developed an external beam facility for the 1.1-MV tandem Pelletron accelerator in the Union College Ion Beam Analysis Laboratory. The beam is extracted from an aluminum pipe through a 1 / 4 ' ' diameter window with a 7.5- μm thick Kapton foil. This external beam facility allows us to perform ion beam analysis on samples that cannot be put under vacuum, including wet samples and samples too large to fit into the scattering chamber. We have commissioned the new facility by performing proton induced X-ray emission (PIXE) analysis of several samples of environmental interest. These include samples of artificial turf, running tracks, and a human tooth with an amalgam filling. A 1.7-MeV external proton beam was incident on the samples positioned 2 cm from the window. The resulting X-rays were measured using a silicon drift detector and were analyzed using GUPIX software to determine the concentrations of elements in the samples. The results on the human tooth indicate that while significant concentrations of Hg, Ag, and Sn are present in the amalgam filling, only trace amounts of Hg appear to have leached into the tooth. The artificial turf and running tracks show rather large concentrations of a broad range of elements and trace amounts of Pb in the turf infill.

  7. A Monte Carlo-based treatment-planning tool for ion beam therapy

    CERN Document Server

    Böhlen, T T; Dosanjh, M; Ferrari, A; Haberer, T; Parodi, K; Patera, V; Mairan, A

    2013-01-01

    Ion beam therapy, as an emerging radiation therapy modality, requires continuous efforts to develop and improve tools for patient treatment planning (TP) and research applications. Dose and fluence computation algorithms using the Monte Carlo (MC) technique have served for decades as reference tools for accurate dose computations for radiotherapy. In this work, a novel MC-based treatment-planning (MCTP) tool for ion beam therapy using the pencil beam scanning technique is presented. It allows single-field and simultaneous multiple-fields optimization for realistic patient treatment conditions and for dosimetric quality assurance for irradiation conditions at state-of-the-art ion beam therapy facilities. It employs iterative procedures that allow for the optimization of absorbed dose and relative biological effectiveness (RBE)-weighted dose using radiobiological input tables generated by external RBE models. Using a re-implementation of the local effect model (LEM), theMCTP tool is able to perform TP studies u...

  8. Proposal for an intense slow positron beam facility at PSI

    International Nuclear Information System (INIS)

    Waeber, W.B.; Taqqu, D.; Zimmermann, U.; Solt, G.

    1990-05-01

    In the domain of condensed matter physics and materials sciences monoenergetic slow positrons in the form of highest intensity beams are demonstrated to be extreamly useful and considered to be highly needed. This conclusion has been reached and the scientific relevance of the positron probe has been highlighted at an international workshop in November 1989 at PSI, where the state of the art and the international situation on slow positron beams, the fields of application of intense beams and the technical possibilities at PSI for installing intense positron sources have been evaluated. The participants agreed that a high intensity beam as a large-scale user facility at PSI would serve fundamental and applied research. The analysis of responses given by numerous members of a widespread positron community has revealed a large research potential in the domain of solid-state physics, atomic physics and surface, thin-film and defect physics, for example. The excellent feature of slow positron beams to be a suitable probe also for lattice defects near surfaces or interfaces has attracted the interest not only of science but also of industry.In this report we propose the installation of an intense slow positron beam facility at PSI including various beam lines of different qualities and based on the Cyclotron production of β + emitting source material and on a highest efficiency moderation scheme which exceeds standard moderation efficiencies by two orders of magnitude. In its proposed form, the project is estimated to be realizable in the nineties and costs will amount to between 15 and 20 MSFr. (author) 10 figs., 6 tabs., 78 refs

  9. Overview of Light-Ion Beam Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Chu, William T.

    2006-03-16

    treatment volume compared to those in conventional (photon) treatments. Wilson wrote his personal account of this pioneering work in 1997. In 1954 Cornelius Tobias and John Lawrence at the Radiation Laboratory (former E.O. Lawrence Berkeley National Laboratory) of the University of California, Berkeley performed the first therapeutic exposure of human patients to hadron (deuteron and helium ion) beams at the 184-Inch Synchrocyclotron. By 1984, or 30 years after the first proton treatment at Berkeley, programs of proton radiation treatments had opened at: University of Uppsala, Sweden, 1957; the Massachusetts General Hospital-Harvard Cyclotron Laboratory (MGH/HCL), USA, 1961; Dubna (1967), Moscow (1969) and St Petersburg (1975) in Russia; Chiba (1979) and Tsukuba (1983) in Japan; and Villigen, Switzerland, 1984. These centers used the accelerators originally constructed for nuclear physics research. The experience at these centers has confirmed the efficacy of protons and light ions in increasing the tumor dose relative to normal tissue dose, with significant improvements in local control and patient survival for several tumor sites. M.R. Raju reviewed the early clinical studies. In 1990, the Loma Linda University Medical Center in California heralded in the age of dedicated medical accelerators when it commissioned its proton therapy facility with a 250-MeV synchrotron. Since then there has been a relatively rapid increase in the number of hospital-based proton treatment centers around the world, and by 2006 there are more than a dozen commercially-built facilities in use, five new facilities under construction, and more in planning stages. In the 1950s larger synchrotrons were built in the GeV region at Brookhaven (3-GeV Cosmotron) and at Berkeley (6-GeV Bevatron), and today most of the world's largest accelerators are synchrotrons. With advances in accelerator design in the early 1970s, synchrotrons at Berkeley and Princeton accelerated ions with atomic numbers

  10. Overview of Light-Ion Beam Therapy

    International Nuclear Information System (INIS)

    Chu, William T.

    2006-01-01

    compared to those in conventional (photon) treatments. Wilson wrote his personal account of this pioneering work in 1997. In 1954 Cornelius Tobias and John Lawrence at the Radiation Laboratory (former E.O. Lawrence Berkeley National Laboratory) of the University of California, Berkeley performed the first therapeutic exposure of human patients to hadron (deuteron and helium ion) beams at the 184-Inch Synchrocyclotron. By 1984, or 30 years after the first proton treatment at Berkeley, programs of proton radiation treatments had opened at: University of Uppsala, Sweden, 1957; the Massachusetts General Hospital-Harvard Cyclotron Laboratory (MGH/HCL), USA, 1961; Dubna (1967), Moscow (1969) and St Petersburg (1975) in Russia; Chiba (1979) and Tsukuba (1983) in Japan; and Villigen, Switzerland, 1984. These centers used the accelerators originally constructed for nuclear physics research. The experience at these centers has confirmed the efficacy of protons and light ions in increasing the tumor dose relative to normal tissue dose, with significant improvements in local control and patient survival for several tumor sites. M.R. Raju reviewed the early clinical studies. In 1990, the Loma Linda University Medical Center in California heralded in the age of dedicated medical accelerators when it commissioned its proton therapy facility with a 250-MeV synchrotron. Since then there has been a relatively rapid increase in the number of hospital-based proton treatment centers around the world, and by 2006 there are more than a dozen commercially-built facilities in use, five new facilities under construction, and more in planning stages. In the 1950s larger synchrotrons were built in the GeV region at Brookhaven (3-GeV Cosmotron) and at Berkeley (6-GeV Bevatron), and today most of the world's largest accelerators are synchrotrons. With advances in accelerator design in the early 1970s, synchrotrons at Berkeley and Princeton accelerated ions with atomic numbers between 6 and 18, at

  11. Radiation protection at hadron therapy facilities

    International Nuclear Information System (INIS)

    Pelliccioni, M.

    2011-01-01

    The Italian National Centre for Oncological Hadron-therapy is currently under construction in Pavia. It is designed for the treatment of deep-seated tumours (up to a depth of 27 cm of water equivalent) with proton and C-ion beams as well as for both clinical and radio-biological research. The particles will be accelerated by a 7-MeV u -1 LINAC injector and a 400-MeV u -1 synchrotron. In the first phase of the project, three treatment rooms will be in operation, equipped with four fixed beams, three horizontal and one vertical. The accelerators are currently undergoing commissioning. The main radiation protection problems encountered (shielding, activation, etc.) are hereby illustrated and discussed in relation to the constraints set by the Italian national authorities. (authors)

  12. Beam Diagnostics for the BNL Energy Recovery Linac Test Facility

    International Nuclear Information System (INIS)

    Cameron, Peter; Ben-Zvi, Ilan; Blaskiewicz, Michael; Brennan, Michael; Connolly, Roger; Dawson, William; Degen, Chris; DellaPenna, Al; Gassner, David; Kesselman, Martin; Kewish, Jorg; Litvinenko, Vladimir; Mead, Joseph; Oerter, Brian; Russo, Tom; Vetter, Kurt; Yakimenko, Vitaly

    2004-01-01

    An Energy Recovery Linac (ERL) test facility is presently under construction at BNL. The goals of this test facility are first to demonstrate stable intense CW electron beam with parameters typical for the RHIC e-cooling project (and potentially for eRHIC), second to test novel elements of the ERL (high current CW photo-cathode, superconducting RF cavity with HOM dampers, and feedback systems), and finally to test lattice dependence of stability criteria. Planned diagnostics include position monitors, loss monitors, transverse profile monitors (both optical and wires), scrapers/halo monitors, a high resolution differential current monitor, phase monitors, an energy spread monitor, and a fast transverse monitor (for beam break-up studies and the energy feedback system). We discuss diagnostics challenges that are unique to this project, and present preliminary system specifications. In addition, we include a brief discussion of the timing system

  13. CEBAF [Continuous Electron Beam Accelerator Facility] scientific program

    International Nuclear Information System (INIS)

    Gross, F.

    1986-01-01

    The principal scientific mission of the Continuous Electron Beam Facility (CEBAF) is to study collective phenomena in cold (or normal) nucler matter in order to understand the structure and behavior of macroscopic systems constructed from nuclei. This document discusses in broad popular terms those issues which the CEBAF experimental and theoretical program are designed to address. Specific experimental programs currently planned for CEBAF are also reivewed. 35 refs., 19 figs

  14. Proportional counter measurements in neutron therapy beams

    International Nuclear Information System (INIS)

    Menzel, H.G.

    1984-01-01

    Dosimetry for clinical neutron therapy requires a characterization of radiation quality in addition to the specification of absorbed dose. Generally, a very simple approach has been adopted which consists in separating total absorbed dose into neutron and photon fractions. This is explained by the requirement of clinical dosimetry to apply methods suitable for routine measurements, by the lack of generally accepted improved alternatives, and by the fact that radiation quality is only one of several problems in neutron therapy not sufficiently solved. Spectra measured with low-pressure tissue-equivalent proportional counters (experimental microdosimetry) provide a detailed description of the physical properties of the radiation field at neutron therapy facilities. These descriptions are suitable for explaining the influence of different parameters (collimation, field size, phantom) on radiation quality. Although the physical properties of the radiation field as described by the measured microdosimetric distributions and quantities are not the only properties relevant for radiation effects, in general there are reasons to believe that they provide a suitable radiation quality characterization for the limited range of applications in neutron therapy. (author)

  15. An irradiation facility with a horizontal beam for radiobiological studies

    International Nuclear Information System (INIS)

    Czub, J.; Adamus, T.; Banas, D.

    2006-01-01

    A facility with a horizontal beam for radiobiological experiments with heavy ions has been designed and constructed at the Heavy Ion Laboratory in Warsaw University. The facility is optimal to investigate the radiobiological effects of charged heavy particles on a cellular or molecular level as the plateau of the Bragg curve as well as in the Bragg peak. The passive beam spread out by a thin scattering foil provides a homogeneous irradiation field over an area of at least 1 x 1 cm 2 . For in vitro irradiation of biological samples the passive beam spreading combined with the x - y mechanical scanning of the irradiated sample was found to be an optimum solution. Using x - y step motor, the homogenous beam of ions with the energy loss range in the cells varied from 1 MeV/μm to 200 keV/μm is able to cover a 6 cm in diameter Petri dish that holds the biological samples. Moreover on-line fluence monitoring based on single-particle counting is performed to determine the dose absorbed by cells. Data acquisition system for dosimetry and ion monitoring based on a personal computer is described. (author)

  16. The FLUKA code for application of Monte Carlo methods to promote high precision ion beam therapy

    CERN Document Server

    Parodi, K; Cerutti, F; Ferrari, A; Mairani, A; Paganetti, H; Sommerer, F

    2010-01-01

    Monte Carlo (MC) methods are increasingly being utilized to support several aspects of commissioning and clinical operation of ion beam therapy facilities. In this contribution two emerging areas of MC applications are outlined. The value of MC modeling to promote accurate treatment planning is addressed via examples of application of the FLUKA code to proton and carbon ion therapy at the Heidelberg Ion Beam Therapy Center in Heidelberg, Germany, and at the Proton Therapy Center of Massachusetts General Hospital (MGH) Boston, USA. These include generation of basic data for input into the treatment planning system (TPS) and validation of the TPS analytical pencil-beam dose computations. Moreover, we review the implementation of PET/CT (Positron-Emission-Tomography / Computed- Tomography) imaging for in-vivo verification of proton therapy at MGH. Here, MC is used to calculate irradiation-induced positron-emitter production in tissue for comparison with the +-activity measurement in order to infer indirect infor...

  17. Neutron beam facilities at the Australian Replacement Research Reactor

    International Nuclear Information System (INIS)

    Kennedy, Shane; Robinson, Robert; Hunter, Brett

    2001-01-01

    Australia is building a research reactor to replace the HIFAR reactor at Lucas Heights by the end of 2005. Like HIFAR, the Replacement Research Reactor will be multipurpose with capabilities for both neutron beam research and radioisotope production. It will be a pool-type reactor with thermal neutron flux (unperturbed) of 4 x 10 14 n/cm 2 /sec and a liquid D 2 cold neutron source. Cold and thermal neutron beams for neutron beam research will be provided at the reactor face and in a large neutron guide hall. Supermirror neutron guides will transport cold and thermal neutrons to the guide hall. The reactor and the associated infrastructure, with the exception of the neutron beam instruments, is to be built by INVAP S.E. under contract. The neutron beam instruments will be developed by ANSTO, in consultation with the Australian user community. This status report includes a review the planned scientific capabilities, a description of the facility and a summary of progress to date. (author)

  18. Beam tests on a proton linac booster for hadron therapy

    CERN Document Server

    De Martinis, C; Berra, P; Birattari, C; Calabretta, L; Crandall, K; Giove, D; Masullo, M R; Mauri, M; Rosso, E; Rovelli, A; Serafini, L; Szeless, Balázs; Toet, D Z; Vaccaro, Vittorio G; Weiss, M; Zennaro, R

    2002-01-01

    LIBO is a 3 GHz modular side-coupled proton linac booster designed to deliver beam energies up to 200 MeV, as required for the therapy of deep seated tumours. The injected beam of 50 to 70 MeV is produced by a cyclotron like those in several hospitals and research institutes. A full-scale prototype of the first module with an input/output energy of 62/74 MeV, respectively, was designed and built in 1999 and 2000. Full power RF tests were carried out successfully at CERN using a test facility at LIL at the end of the year 2000. In order to prove the feasibility of the acceleration process, an experimental setup with this module was installed at the INFN Laboratorio Nazionale del Sud (LNS) in Catania during 2001. The superconducting cyclotron provided the 62 MeV test beam. A compact solid-state RF modulator with a 4 MW klystron, made available by IBA-Scanditronix, was put into operation to power the linac. In this paper the main features of the accelerator are reviewed and the experimental results obtained duri...

  19. A beam monitor based on MPGD detectors for hadron therapy

    Science.gov (United States)

    Altieri, P. R.; Di Benedetto, D.; Galetta, G.; Intonti, R. A.; Mercadante, A.; Nuzzo, S.; Verwilligen, P.

    2018-02-01

    Remarkable scientific and technological progress during the last years has led to the construction of accelerator based facilities dedicated to hadron therapy. This kind of technology requires precise and continuous control of position, intensity and shape of the ions or protons used to irradiate cancers. Patient safety, accelerator operation and dose delivery should be optimized by a real time monitoring of beam intensity and profile during the treatment, by using non-destructive, high spatial resolution detectors. In the framework of AMIDERHA (AMIDERHA - Enhanced Radiotherapy with HAdron) project funded by the Ministero dell'Istruzione, dell'Università e della Ricerca (Italian Ministry of Education and Research) the authors are studying and developing an innovative beam monitor based on Micro Pattern Gaseous Detectors (MPDGs) characterized by a high spatial resolution and rate capability. The Monte Carlo simulation of the beam monitor prototype was carried out to optimize the geometrical set up and to predict the behavior of the detector. A first prototype has been constructed and successfully tested using 55Fe, 90Sr and also an X-ray tube. Preliminary results on both simulations and tests will be presented.

  20. Dosimetry auditing procedure with alanine dosimeters for light ion beam therapy

    DEFF Research Database (Denmark)

    Ableitinger, Alexander; Vatnitsky, Stanislav; Herrmann, Rochus

    2013-01-01

    Background and purpose In the next few years the number of facilities providing ion beam therapy with scanning beams will increase. An auditing process based on an end-to-end test (including CT imaging, planning and dose delivery) could help new ion therapy centres to validate their entire logistic...... of the biological dose is out of scope of the current work. Materials and methods The audit procedure was based on a homogeneous phantom that mimics the dimension of a head (20 × 20 × 21 cm3). The phantom can be loaded either with an ionisation chamber or 20 alanine dosimeters plus 2 radiochromic EBT films. Dose...... of about 3%. Conclusions Alanine dosimeters are suitable detectors for dosimetry audits in ion beam therapy and the presented end-to-end test is feasible. If further studies show similar results, this dosimetric audit could be implemented as a credentialing procedure for clinical proton and carbon beam...

  1. External beam radiation therapy for prostate cancer

    International Nuclear Information System (INIS)

    Forman, Jeffrey D.

    1996-01-01

    Purpose/Objectives: The intent of this course is to review the issues involved in the management of non-metastatic adenocarcinoma of the prostate. -- The value of pre-treatment prognostic factors including stage, grade and PSA value will be presented, and their value in determining therapeutic strategies will be discussed. -- Controversies involving the simulation process and treatment design will be presented. The value of CT scanning, Beams-Eye View, 3-D planning, intravesicle, intraurethral and rectal contrast will be presented. The significance of prostate and patient movement and strategies for dealing with them will be presented. -- The management of low stage, low to intermediate grade prostate cancer will be discussed. The dose, volume and timing of irradiation will be discussed as will the role of neo-adjuvant hormonal therapy, neutron irradiation and brachytherapy. The current status of radical prostatectomy and cryotherapy will be summarized. Treatment of locally advanced, poorly differentiated prostate cancer will be presented including a discussion of neo-adjuvant and adjuvant hormones, dose-escalation and neutron irradiation. -- Strategies for post-radiation failures will be presented including data on cryotherapy, salvage prostatectomy and hormonal therapy (immediate, delayed and/or intermittent). New areas for investigation will be reviewed. -- The management of patients post prostatectomy will be reviewed. Data on adjuvant radiation and therapeutic radiation for biochemical or clinically relapsed patients will be presented. This course hopes to present a realistic and pragmatic overview for treating patients with non-metastatic prostatic cancer

  2. Materials for neutron beam optimization for boron neutron capture therapy

    International Nuclear Information System (INIS)

    Matsumoto, Tetsuo

    2001-01-01

    Several prospective materials (neutron filter/moderator, beam reflector, gamma ray shielding and beam collimator) were studied with a view to generating thermal and epithermal neutron beams suited for boron neutron capture therapy (BNCT). The beams are delivered from the thermal and thermalizing column exits situated on two opposite faces of a TRIGA-II type reactor. An investigation was performed with Monte Carlo calculations from a viewpoint of obtaining sufficiently intense thermal and epithermal neutron beams separately, and little adulterated both with neutrons of extraneous energy ranges and with gamma rays. High-density graphite (G) would be the most suitable material for thermal neutron beams as a neutron filter/moderator, and the combination of aluminum (Al) and aluminum fluoride (AlF 3 ) for epithermal neutron beams. The graphite would be also the most promising material for thermal neutron beams as a beam reflector while for epithermal neutron beams the choice would be lead fluoride (PbF 2 ). The PbF 2 would be also the most suitable material for epithermal neutron beams as a gamma ray shielding, and bismuth (Bi) for thermal neutron beam. The PbF 2 would be also the most useful material for epithermal neutron beam as a beam collimator while for thermal neutron beam the choice would be the graphite. The epithermal neutron beam for BNCT could be optimized with the progressive use of PbF 2 . (author)

  3. Aifira: An ion beam facility for multidisciplinary research

    Science.gov (United States)

    Sorieul, S.; Alfaurt, Ph.; Daudin, L.; Serani, L.; Moretto, Ph.

    2014-08-01

    During the last decade, the CENBG (Centre d'Études Nucléaires de Bordeaux Gradignan) commissioned a new facility called AIFIRA (Applications Interdisciplinaires des Faisceaux d'ions en Région Aquitaine). It allowed the development of a multidisciplinary activity based on the "in-house" expertise of CENBG in ion beam analysis. The great flexibility offered by the five beam lines confers a lot of possibilities for chemical analysis and nuclear physics. Indeed, not only the macrobeam and the external beam lines provide the full set of IBA techniques for routine sample analysis but an additional beam line is devoted to the production of monoenergetic neutrons through the interaction of the incoming ion with selected targets. In addition, the two high-resolution microbeam lines are used for chemical analyses, 2D/3D imaging, and targeted cell irradiation. Besides, the combination of the nanobeam line flexibility, the uniqueness of the micro-irradiation design completed by the internal CENBG expertise confers a great specificity to AIFIRA in biomedical field. After a detailed technical overview of the platform, the article focuses on the two high-resolution lines as they tap most of the activity. Thus a quick overview of the most significant results concerning biomedical samples is proposed in order to highlight the analytical possibilities of AIFIRA microbeam lines. A summary of the development status of the micro-irradiation line is also done.

  4. Aifira: An ion beam facility for multidisciplinary research

    Energy Technology Data Exchange (ETDEWEB)

    Sorieul, S., E-mail: sorieul@cenbg.in2p3.fr; Alfaurt, Ph.; Daudin, L.; Serani, L.; Moretto, Ph.

    2014-08-01

    During the last decade, the CENBG (Centre d’Études Nucléaires de Bordeaux Gradignan) commissioned a new facility called AIFIRA (Applications Interdisciplinaires des Faisceaux d’ions en Région Aquitaine). It allowed the development of a multidisciplinary activity based on the “in-house” expertise of CENBG in ion beam analysis. The great flexibility offered by the five beam lines confers a lot of possibilities for chemical analysis and nuclear physics. Indeed, not only the macrobeam and the external beam lines provide the full set of IBA techniques for routine sample analysis but an additional beam line is devoted to the production of monoenergetic neutrons through the interaction of the incoming ion with selected targets. In addition, the two high-resolution microbeam lines are used for chemical analyses, 2D/3D imaging, and targeted cell irradiation. Besides, the combination of the nanobeam line flexibility, the uniqueness of the micro-irradiation design completed by the internal CENBG expertise confers a great specificity to AIFIRA in biomedical field. After a detailed technical overview of the platform, the article focuses on the two high-resolution lines as they tap most of the activity. Thus a quick overview of the most significant results concerning biomedical samples is proposed in order to highlight the analytical possibilities of AIFIRA microbeam lines. A summary of the development status of the micro-irradiation line is also done.

  5. Synchrotron accelerator technology for proton beam therapy with high accuracy

    International Nuclear Information System (INIS)

    Hiramoto, Kazuo

    2009-01-01

    Proton beam therapy was applied at the beginning to head and neck cancers, but it is now extended to prostate, lung and liver cancers. Thus the need for a pencil beam scanning method is increasing. With this method radiation dose concentration property of the proton beam will be further intensified. Hitachi group has supplied a pencil beam scanning therapy system as the first one for M. D. Anderson Hospital in United States, and it has been operational since May 2008. Hitachi group has been developing proton therapy system to correspond high-accuracy proton therapy to concentrate the dose in the diseased part which is located with various depths, and which sometimes has complicated shape. The author described here on the synchrotron accelerator technology that is an important element for constituting the proton therapy system. (K.Y.)

  6. Nanoscale insights into ion-beam cancer therapy

    CERN Document Server

    2017-01-01

    This book provides a unique and comprehensive overview of state-of-the-art understanding of the molecular and nano-scale processes that play significant roles in ion-beam cancer therapy. It covers experimental design and methodology, and reviews the theoretical understanding of the processes involved. It offers the reader an opportunity to learn from a coherent approach about the physics, chemistry and biology relevant to ion-beam cancer therapy, a growing field of important medical application worldwide. The book describes phenomena occurring on different time and energy scales relevant to the radiation damage of biological targets and ion-beam cancer therapy from the molecular (nano) scale up to the macroscopic level. It illustrates how ion-beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue whilst maximizing cell-killing within the tumour, offering a significant development in cancer therapy. The full potential ...

  7. Neutron beam facilities at Australia's replacement research reactor

    International Nuclear Information System (INIS)

    Robinson, R.A.

    2003-01-01

    Full text: The 20-MW Australian Replacement Research Reactor represents possibly the greatest single research infrastructure investment in Australia's history. Construction of the facility has commenced, following award of the construction contract in July 2000, and the construction licence in April 2002. The project includes a large state-of-the-art liquid deuterium cold-neutron source and supermirror guides feeding a large modern guide hall, in which most of the instruments are placed. Alongside the guide hall, there is good provision of laboratory, office and space for support activities. While the facility has 'space' for up to 18 instruments, the project has funding for an initial set of 8 instruments, which will be ready when the reactor is fully operational in January 2006. Instrument performance will be competitive with the best research-reactor facilities anywhere, and our goal is to be in the top 3 such facilities worldwide. Staff to lead the design effort and man these instruments have been hired on the international market from leading overseas facilities, and from within Australia, and 6 out of 8 instruments have been specified and costed. At present the instrumentation project carries ∼15% contingency. An extensive dialogue has taken place with the domestic user community and our international peers, via various means including a series of workshops over the last 2 years covering all 8 instruments, emerging areas of application like biology and the earth sciences, and computing infrastructure for the instruments. In December 2002, ANSTO formed the Bragg Institute, with the intent of nurturing strong external partnerships, and covering all aspects of neutron and X-ray scattering, including research using synchrotron radiation. I will discuss the present status and predicted performance of the neutron-beam facilities at the Replacement Reactor, and the opportunities that all of this presents for scientific research in Australia, with particular

  8. Progress report of the innovated KIST ion beam facility

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Joonkon; Eliades, John A.; Yu, Byung-Yong; Lim, Weon Cheol; Chae, Keun Hwa; Song, Jonghan, E-mail: jonghansong@gmail.com

    2017-01-15

    The Korea Institute of Science and Technology (KIST, Seoul, Republic of (S.) Korea) ion beam facility consists of three electrostatic accelerators: a 400 kV single ended ion implanter, a 2 MV tandem accelerator system and a 6 MV tandem accelerator system. The 400 kV and 6 MV systems were purchased from High Voltage Engineering Europa (HVEE, Netherlands) and commissioned in 2013, while the 2 MV system was purchased from National Electrostatics Corporation (NEC, USA) in 1995. These systems are used to provide traditional ion beam analysis (IBA), isotope ratio analysis (ex. accelerator mass spectrometry, AMS), and ion implantation/irradiation for domestic industrial and academic users. The main facility is the 6 MV HVEE Tandetron system that has an AMS line currently used for {sup 10}Be, {sup 14}C, {sup 26}Al, {sup 36} Cl, {sup 41}Ca and {sup 129}I analyses, and three lines for IBA that are under construction. Here, these systems are introduced with their specifications and initial performance results.

  9. Development of the RRR cold neutron beam facility

    International Nuclear Information System (INIS)

    Lovotti, Osvaldo; Masriera, Nestor; Lecot, Carlos; Hergenreder, Daniel

    2002-01-01

    This paper describes some general design issues on the neutron beam facilities (cold neutron source and neutron beam transport system) of the Replacement Research Reactor (RRR) for the Australian Nuclear Science and Technology Organisation (ANSTO). The description covers different aspect of the design: the requirements that lead to an innovative design, the overall design itself, the definition of a technical approach in order to develop the necessary design solutions, and finally the organizational framework by which international expertise from five different institutions is integrated. From the technical viewpoint, the RRR-CNS is a liquid Deuterium (LD2) moderator, sub-cooled to ensure maximum moderation efficiency, flowing within a closed natural circulation thermosyphon loop. The thermosyphon is surrounded by a zirconium alloy CNS vacuum containment that provides thermal insulation and a multiple barriers scheme to prevent Deuterium from mixing with water or air. Consistent with international practice, this vessel is designed to withstand any hypothetical energy reaction should Deuterium and air mix in its interior. The 'cold' neutrons are then taken by the NBTS and transported by the neutron guide system into the reactor beam hall and neutron guide hall, where neutron scattering instruments are located. From the management viewpoint, the adopted distributed scheme is successful to manage the complex interfacing between highly specialized technologies, allowing a smooth integration within the project. (author)

  10. Investigation of plasma–surface interaction at plasma beam facilities

    Energy Technology Data Exchange (ETDEWEB)

    Kurnaev, V., E-mail: kurnaev@plasma.mephi.ru [National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Kashirskoe sh. 31, 115409 Moscow (Russian Federation); Vizgalov, I.; Gutorov, K. [National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Kashirskoe sh. 31, 115409 Moscow (Russian Federation); Tulenbergenov, T.; Sokolov, I.; Kolodeshnikov, A.; Ignashev, V.; Zuev, V.; Bogomolova, I. [Institute of Atomic Energy, National Nuclear Center the Republic of Kazakhstan, Street Krasnoarmejsky, 10, 071100 Kurchatov (Kazakhstan); Klimov, N. [SRC RF TRINITI, ul. Pushkovykh, vladenie 12, Troitsk, 142190 Moscow (Russian Federation)

    2015-08-15

    The new Plasma Beam Facility (PBF) has been put into operation for assistance in testing of plasma faced components at Material Science Kazakhstan Tokamak (KTM). PBF includes a powerful electron gun (up to 30 kV, 1 A) and a high vacuum chamber with longitudinal magnetic field coils (up to 0.2 T). The regime of high vacuum electron beam transportation is used for thermal tests with power density at the target surface up to 10 GW/m{sup 2}. The beam plasma discharge (BPD) regime with a gas-puff is used for generation of intensive ion fluxes up to 3 ⋅ 10{sup 22} m{sup −2} s{sup −1}. Initial tests of the KTM PBF’s capabilities were carried out: various discharge regimes, carbon deposits cleaning, simultaneous thermal and ion impacts on radiation cooled refractory targets. With a water-cooled target the KTM PBF could be used for high heat flux tests of materials (validated by the experiment with W mock-up at the PR-2 PBF)

  11. Environmental assessment: Continuous Electron Beam Accelerator Facility, Newport News, Virginia

    International Nuclear Information System (INIS)

    1987-01-01

    This Environmental Assessment has been prepared by the US Department of Energy (DOE) to fulfill its obligations pursuant to Sect. 102 of the National Environmental Policy Act (NEPA) of 1969 (Public Law 91-190). The proposed federal action addressed in this document is DOE's funding of a Continuous Electron Beam Accelerator Facility (CEBAF) at Newport News, Virginia. DOE intends to contract with the Southeastern Universities Research Association (SURA) for operation of CEBAF, a continuous wave (CW) linear accelerator system (linac) capable of providing high-duty-factor beams throughout the energy range from 0.5 to 4.0 GeV. CEBAF will be the first of its kind worldwide and will offer a multi-GeV energy, high-intensity, high-duty-factor electron beam for use by the US nuclear physics community in research on the states of nuclear matter and the short-distance behavior of nuclei. The CEBAF project is largely in the conceptual design stage, with some components in the preliminary design stage. Construction is anticipated to begin in 1987 and be completed by 1992

  12. Maintenance schemes for the ITER neutral beam test facility

    International Nuclear Information System (INIS)

    Zaccaria, P.; Dal Bello, S.; Marcuzzi, D.; Masiello, A.; Coniglio, A.; Antoni, V.; Cordier, J.J.; Hemsworth, R.; Jones, T.; Di Pietro, E.; Mondino, P.L.

    2004-01-01

    The ITER neutral beam test facility (NBTF) is planned to be built, after the approval of the ITER construction and the choice of the ITER site, with the agreement of the ITER International Team and of the JA and RF participant teams. The key purpose is to progressively increase the performance of the first ITER injector and to demonstrate its reliability at the maximum operation parameters: power delivered to the plasma 16.5 MW, beam energy 1 MeV, accelerated D - ion current 40 A, pulse length 3600 s. Several interventions for possible modifications and for maintenance are expected during the early operation of the ITER injector in order to optimize the beam generation, aiming and steering. The maintenance scheme and the related design solutions are therefore a very important aspect to be considered for the NBTF design. The paper describes consistently the many interrelated aspects of the design, such as the optimisation of the vessel and cryopump geometry, in order to get a better maintenance flexibility, an easier man access and a larger access for diagnostic and monitoring. (authors)

  13. Development of beam instruments at JAERI cyclotron facility

    Energy Technology Data Exchange (ETDEWEB)

    Okumura, Susumu; Fukuda, Mitsuhiro; Ishibori, Ikuo; Agematsu, Takashi; Yokota, Watalu; Nara, Takayuki; Nakamura, Yoshiteru; Arakawa, Kazuo [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    1997-03-01

    A beam phase monitor and two kinds of fluence distribution monitors have been developed for measuring characteristics of cyclotron beams. The beam phase monitor provides a beam phase signal for tuning a beam chopping system and a beam phase selection system. A two-dimensional fluence distribution on a large area is measured with fluence distribution monitors. (author)

  14. Status of the realization of the neutral beam test facility

    International Nuclear Information System (INIS)

    Toigo, Vanni

    2015-01-01

    The ITER Neutral Beam Injectors (NBI) are required to deliver 16.5 MW of additional heating power to the plasma, accelerating negative ions up to -1 MV with a beam current of 40A lasting up to 1 hour. Since these outstanding requirements were never achieved all together so far, the realization of a Neutral Beam Test Facility (NBTF), called PRIMA, currently under construction in Padova, was launched with the aim to test the operation of the NB injector and to study the relevant physical and technological issues, in advance to the implementation in ITER. Two projects are under development: MITICA and SPIDER. MITICA is a full scale prototype of the ITER NB injector; the design is based on a similar scheme and layout, with the same power supply system and also the control and protection systems are being designed according to the ITER rules and constraints. The HV components are procured by JADA; the low voltage ones and the injector are procured by F4E. SPIDER project is an ion source with the same characteristics of the ITER one, specifically addressed to study the issues related to the RF operation; for this reason, the beam energy is limited to 100keV. It can generate both Hydrogen and Deuterium Ions; the design includes provisions to filter electrons and also to allow the use of cesium to attain the high values of current density required. SPIDER is procured by F4E and INDA. The construction of PRIMA buildings and auxiliaries, started in autumn 2008, was completed in summer 2015. SPIDER plant systems procurement is well advanced and some systems are under installation or site acceptance tests. In 2016 integrated commissioning and power supply integrated tests will be performed followed by the beginning of the first experimental phase. MITICA design was completed; many procurement contracts have been signed or will be launched in the next months. Installation activity will start in December 2015 with the installation of the first HV power supply components provided

  15. Characterization of a tagged $\\gamma$-ray beam line at the DAFNE Beam Test Facility

    CERN Document Server

    Cattaneo, P W; Boffelli, F; Bulgarelli, A; Buonomo, B; Chen, A W; D’Ammando, F; FoggettA, L; Froysland, T; Fuschino, F; Galli, M; Gianotti, F; Giuliani, A; Longo, F; Marisaldi, M; Mazzitelli, G; Pellizzoni, A; Prest, M; Pucella, G; Quintieri, L; Rappoldi, A; Tavani, M; Trifoglio, M; Trois, A; Valente, P; Vallazza, E; Vercellone, S; Zambra, A; Barbiellini, G; Caraveo, P; Cocco, V; Costa, E; De Paris, G; Del Monte, E; Di Cocco, G; Donnarumma, I; Evangelista, Y; Feroci, M; Ferrari, A; Fiorini, M; Labanti, C; Lapshov, I; Lazzarotto, F; Lipari, P; Mastropietro, M; Mereghetti, S; Morelli, E; Moretti, E; Morselli, A; Pacciani, L; Perotti, F; Piano, G; Picozza, P; Pilia, M; Porrovecchio, G; Rapisarda, M; Rubini, A; Sabatini, S; Soffitta, P; Striani, E; Vittorini, V; Zanello, D; Colafrancesco, S; Giommi, P; Pittori, C; Santolamazza, P; Verrecchia, F; Salotti, L

    2012-01-01

    At the core of the AGILE scientific instrument, designed to operate on a satellite, there is the Gamma Ray Imaging Detector (GRID) consisting of a Silicon Tracker (ST), a Cesium Iodide Mini-Calorimeter and an Anti-Coincidence system of plastic scintillator bars. The ST needs an on-ground calibration with a γ-ray beam to validate the simulation used to calculate the energy response function and the effective area versus the energy and the direction of the γ rays. A tagged γ-ray beam line was designed at the Beam Test Facility (BTF) of the INFN Laboratori Nazionali of Frascati (LNF), based on an electron beam generating γ-rays through bremsstrahlung in a position-sensitive target. The γ-ray energy is deduced by difference with the post-bremsstrahlung electron energy [1] and [2]. The electron energy is measured by a spectrometer consisting of a dipole magnet and an array of position sensitive silicon strip detectors, the Photon Tagging System (PTS). The use of the combined BTF-PTS system as tagged photon be...

  16. Neutron capture therapy beams at the MIT Research Reactor

    International Nuclear Information System (INIS)

    Choi, J.R.; Clement, S.D.; Harling, O.K.; Zamenhof, R.G.

    1990-01-01

    Several neutron beams that could be used for neutron capture therapy at MITR-II are dosimetrically characterized and their suitability for the treatment of glioblastoma multiforme and other types of tumors are described. The types of neutron beams studied are: (1) those filtered by various thicknesses of cadmium, D2O, 6Li, and bismuth; and (2) epithermal beams achieved by filtration with aluminum, sulfur, cadmium, 6Li, and bismuth. Measured dose vs. depth data are presented in polyethylene phantom with references to what can be expected in brain. The results indicate that both types of neutron beams are useful for neutron capture therapy. The first type of neutron beams have good therapeutic advantage depths (approximately 5 cm) and excellent in-phantom ratios of therapeutic dose to background dose. Such beams would be useful for treating tumors located at relatively shallow depths in the brain. On the other hand, the second type of neutron beams have superior therapeutic advantage depths (greater than 6 cm) and good in-phantom therapeutic advantage ratios. Such beams, when used along with bilateral irradiation schemes, would be able to treat tumors at any depth in the brain. Numerical examples of what could be achieved with these beams, using RBEs, fractionated-dose delivery, unilateral, and bilateral irradiation are presented in the paper. Finally, additional plans for further neutron beam development at MITR-II are discussed

  17. Radiation protection measurements with the variance-covariance method in the stray radiation fields from photon and proton therapy facilities

    DEFF Research Database (Denmark)

    Lillhök, J.; Persson, L.; Andersen, Claus E.

    2017-01-01

    The microdosimetric variance-covariance method was used to study the stray radiation fields from the photon therapy facility at the Technical University of Denmark and the scanned proton therapy beam at the Skandion Clinic in Uppsala, Sweden. Two TEPCs were used to determine the absorbed dose...

  18. Radiotherapy for ocular lesions by electron beam therapy

    International Nuclear Information System (INIS)

    Miyaishi, Kazuo

    1981-01-01

    Radiotherapy can be very significant as the treatment for ocular lesions, eyes need to be preserved as properly as possible on their functions and cosmetics. The appliance of conventional X ray therapy has been gradually abandaned as conventional X ray therapy ceased to be accepted as the general treatment for malignant tumors. Consequently the necessity of electron beam therapy has been rising even as the substituted method for conventional X ray therapy. The department of radiology of Gunma University was obliged to establish a new therapy for ocular lesions, and has been trying electron beam therapy since 1973; It is concluded that electron beam therapy is not at all inferior to conventional X ray therapy as reported above. Basic therapeutic methods for ocular lesions are the following: 1) For epidermoid carcinoma, 600 rads at a time, 3600 - 4200 rads in total is applied by 8 MeV electron twice a week method. 2) For malignant melanoma, 1000 rads at a time, 4000 - 5000 rads in total is applied by 8 MeV electron twice a week method. 3) For orbitar lymphoid neoplasm, Cobalt-60 γ ray or Linac X ray is applied together with electron beam. 4) For embryonal rhabdomyosarcoma, adenoid cystic cancer etc., the therapy for whole body is necessary. 5) For benign tumors, a small dose at a time is applied for a long time. (author)

  19. Experimental support at proton--proton colliding beam facilities

    International Nuclear Information System (INIS)

    Potter, K.

    1977-01-01

    Proton--proton colliding beam facilities have a number of special features which increase the importance of support for experiments when compared to fixed target accelerators: (1) the laboratory system is very close to the center-of-mass system; this affects the geometry and general size of the experiments; (2) the primary p--p interaction is inaccessible, that is, it takes place in an ultrahigh vacuum chamber; and (3) the experiment detection system is necessarily inside the machine structure and becomes very closely linked to it in many respects. An overall picture is given of experimental support based on experience at the CERN ISR under the following headings: Experimental Areas, Scheduling, Intersection Vacuum Chambers, Machine Background, and Magnets for Experiments. The first two of these topics concern the requirements in space and time of an experiment, while the last three are all related to the close interaction between experiment and machine

  20. Optimization of the irradiation beam in the BNCT research facility at IEA-R1 reactor

    International Nuclear Information System (INIS)

    Castro, Vinicius Alexandre de

    2014-01-01

    Boron Neutron Capture Therapy (BNCT) is a radiotherapeutic technique for the treatment of some types of cancer whose useful energy comes from a nuclear reaction that occurs when thermal neutron impinges upon a Boron-10 atom. In Brazil there is a research facility built along the beam hole number 3 of the IEA-R1 research reactor at IPEN, which was designed to perform BNCT research experiments. For a good performance of the technique, the irradiation beam should be mostly composed of thermal neutrons with a minimum as possible gamma and above thermal neutron components. This work aims to monitor and evaluate the irradiation beam on the sample irradiation position through the use of activation detectors (activation foils) and also to propose, through simulation using the radiation transport code, MCNP, new sets of moderators and filters which shall deliver better irradiation fields at the irradiation sample position In this work, a simulation methodology, based on a MCNP card, known as wwg (weight window generation) was studied, and the neutron energy spectrum has been experimentally discriminated at 5 energy ranges by using a new set o activation foils. It also has been concluded that the BNCT research facility has the required thermal neutron flux to perform studies in the area and it has a great potential for improvement for tailoring the irradiation field. (author)

  1. Application of the pencil-beam redefinition algorithm in heterogeneous media for proton beam therapy

    Science.gov (United States)

    Egashira, Y.; Nishio, T.; Hotta, K.; Kohno, R.; Uesaka, M.

    2013-02-01

    In proton beam therapy, changes in the proton range due to lateral heterogeneity may cause serious errors in the dose distribution. In the present study, the pencil-beam redefinition algorithm (PBRA) was applied to proton beam therapy to address the problem of lateral density heterogeneity. In the calculation, the phase-space parameters were characterized for multiple range (i.e. proton energy) bins for given pencil beams. The particles that were included in each pencil beam were transported and redefined periodically until they had stopped. The redefined beams formed a detouring path that was different from that of the non-redefined pencil beams, and the path of each redefined beam was straight. The results calculated by the PBRA were compared with measured proton dose distributions in a heterogeneous slab phantom and an anthropomorphic phantom. Through the beam redefinition process, the PBRA was able to predict the measured proton-detouring effects. Therefore, the PBRA may allow improved calculation accuracy when dealing with lateral heterogeneities in proton therapy applications.

  2. Development of a compact synchrotron for proton beam therapy

    International Nuclear Information System (INIS)

    Ebina, Futaro; Umezawa, Masumi; Nishiuchi, Hideaki; Aoki, Takamichi; Hiramoto, Kazuo; Matsuda, Koji; Umegaki, Kikuo; Furusaka, Michihiro

    2016-01-01

    This research aims to develop a compact synchrotron dedicated for proton beam therapy using a scanning irradiation method. The effective length and magnetic uniformity of the bending magnets in the synchrotron were analyzed by 3D static magnetic field calculations. The calculation results indicate that the shape of the bending magnet satisfies the specification for beam stability. A push-pull multi-feed driven technique allows shortening the length of the FINEMET RF acceleration cavity for the synchrotron from 600 mm to 450 mm. The circumference of the synchrotron is 18 m, which is the world's most compact size for proton beam therapy. (author)

  3. Beam Phase Detection for Proton Therapy Accelerators

    CERN Document Server

    Aminov, Bachtior; Getta, Markus; Kolesov, Sergej; Pupeter, Nico; Stephani, Thomas; Timmer, J

    2005-01-01

    The industrial application of proton cyclotrons for medical applications has become one of the important contributions of accelerator physics during the last years. This paper describes an advanced vector demodulating technique used for non-destructive measurements of beam intensity and beam phase over 360°. A computer controlled I/Q-based phase detector with a very large dynamic range of 70 dB permits the monitoring of beam intensity, phase and eventually energy for wide range of beam currents down to -130 dBm. In order to avoid interference from the fundamental cyclotron frequency the phase detection is performed at the second harmonic frequency. A digital low pass filter with adjustable bandwidth and steepness is implemented to improve accuracy. With a sensitivity of the capacitive pickup in the beam line of 30 nV per nA of proton beam current at 250 MeV, accurate phase and intensity measurements can be performed with beam currents down to 3.3 nA.

  4. High resolution muon computed tomography at neutrino beam facilities

    International Nuclear Information System (INIS)

    Suerfu, B.; Tully, C.G.

    2016-01-01

    X-ray computed tomography (CT) has an indispensable role in constructing 3D images of objects made from light materials. However, limited by absorption coefficients, X-rays cannot deeply penetrate materials such as copper and lead. Here we show via simulation that muon beams can provide high resolution tomographic images of dense objects and of structures within the interior of dense objects. The effects of resolution broadening from multiple scattering diminish with increasing muon momentum. As the momentum of the muon increases, the contrast of the image goes down and therefore requires higher resolution in the muon spectrometer to resolve the image. The variance of the measured muon momentum reaches a minimum and then increases with increasing muon momentum. The impact of the increase in variance is to require a higher integrated muon flux to reduce fluctuations. The flux requirements and level of contrast needed for high resolution muon computed tomography are well matched to the muons produced in the pion decay pipe at a neutrino beam facility and what can be achieved for momentum resolution in a muon spectrometer. Such an imaging system can be applied in archaeology, art history, engineering, material identification and whenever there is a need to image inside a transportable object constructed of dense materials

  5. Noninterceptive beam energy measurements in line D of the Los Alamos Meson Physics Facility

    International Nuclear Information System (INIS)

    Gilpatrick, J.D.; Carter, H.; Plum, M.; Power, J.F.; Rose, C.R.; Shurter, R.B.

    1995-01-01

    Several members of the Accelerator and Operations Technology (AOT) division beam-diagnostics team performed time-of-flight (TOF) beam-energy measurements in line D of the Los Alamos Meson Physics Facility (LAMPF) using developmental beam time. These measurements provided information for a final design of an on-line beam energy measurement. The following paper discusses these measurements and how they apply to the final beam energy measurement design

  6. Ion spectroscopy for improvement of the physical beam model for therapy planning in ion beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Arico, Giulia

    2016-11-23

    Helium and carbon ions enable a more conformal dose distribution, narrower penumbra and higher relative biological effectiveness than photon and proton radiotherapy. However, they may undergo nuclear fragmentation in the patient tissues and the arising secondary fragments affect the delivered biological dose distributions. Currently there is a lack of data regarding ion nuclear fragmentation. One reason is the large size (up to some meters) of the experimental setups required for the investigations. In this thesis a new method is presented, which makes use of versatile pixelated semiconductor detectors (Timepix). This method is based on tracking of single particles and pattern recognition of their signals in the detectors. Measurements were performed at the HIT facility. The mixed radiation field arising from 430 MeV/u carbon ion beams and 221 MeV/u helium ion beams in water and in PMMA targets was investigated. The amounts of primary (carbon or helium) ions detected behind targets with the same water equivalent thickness (WET) were found to be in agreement within the statistical uncertainties. However, more fragments (differences up to 20% in case of H) and narrower lateral particle distributions were measured behind the PMMA than the water targets. The spectra of ions behind tissue surrogates and corresponding water targets with the same WET were analysed. The results obtained with adipose and inner bone surrogates and with the equivalent water phantoms were found to be consistent within the uncertainties. Significant differences in the results were observed in the case of lung and cortical bone surrogates when compared to the water phantoms. The experimental results were compared to FLUKA Monte Carlo simulations. This comparison could contribute to enhance the ion interaction models currently implemented for {sup 12}C and {sup 4}He ion beams.

  7. Anesthesia for pediatric external beam radiation therapy

    International Nuclear Information System (INIS)

    Fortney, Jennifer T.; Halperin, Edward C.; Hertz, Caryn M.; Schulman, Scott R.

    1999-01-01

    Background: For very young patients, anesthesia is often required for radiotherapy. This results in multiple exposures to anesthetic agents over a short period of time. We report a consecutive series of children anesthetized for external beam radiation therapy (EBRT). Methods: Five hundred twelve children ≤ 16 years old received EBRT from January 1983 to February 1996. Patient demographics, diagnosis, anesthesia techniques, monitoring, airway management, complications, and outcome were recorded for the patients requiring anesthesia. Results: One hundred twenty-three of the 512 children (24%) required 141 courses of EBRT with anesthesia. Anesthetized patients ranged in age from 20 days to 11 years (mean 2.6 ± 1.8 ). The frequency of a child receiving EBRT and requiring anesthesia by age cohort was: ≤ 1 year (96%), 1-2 years (93%), 2-3 years (80%), 3-4 years (51%), 4-5 years (36%), 5-6 years (13%), 6-7 years (11%), and 7-16 years (0.7%). Diagnoses included: primary CNS tumor (28%), retinoblastoma (27%), neuroblastoma (20%), acute leukemia (9%), rhabdomyosarcoma (6%), and Wilms' tumor (4%). Sixty-three percent of the patients had been exposed to chemotherapy prior to EBRT. The mean number of anesthesia sessions per patient was 22 ± 16. Seventy-eight percent of the treatment courses were once daily and 22% were twice daily. Anesthesia techniques included: short-acting barbiturate induction + inhalation maintenance (21%), inhalation only (20%), ketamine (19%), propofol only (12%), propofol induction + inhalation maintenance (7%), ketamine induction + inhalation maintenance (6%), ketamine or short-acting barbiturate induction + inhalation maintenance (6%). Monitoring techniques included: EKG (95%), O 2 saturation (93%), fraction of inspired O 2 (57%), and end-tidal CO 2 (55%). Sixty-four percent of patients had central venous access. Eleven of the 74 children with a central line developed sepsis (15%): 6 of the 11 were anesthetized with propofol (55%), 4 with a

  8. A proton beam delivery system for conformal therapy and intensity modulated therapy

    International Nuclear Information System (INIS)

    Yu Qingchang

    2001-01-01

    A scattering proton beam delivery system for conformal therapy and intensity modulated therapy is described. The beam is laterally spread out by a dual-ring double scattering system and collimated by a program-controlled multileaf collimator and patient specific fixed collimators. The proton range is adjusted and modulated by a program controlled binary filter and ridge filters

  9. Development of a Boron Neutron Capture Enhanced Fast Neutron Therapy Beam

    Energy Technology Data Exchange (ETDEWEB)

    Sweezy, Jeremy Ed [Georgia Tech

    2002-01-01

    The combination of fast neutron therapy and boron neutron capture therapy is currently under investigation at several fast neutron therapy centers worldwide. This treatment method, termed boron neutron capture enhanced fast neutron therapy (BNCEFNT) utilizes a boron containing drug to selectively increase the dose to the target tumor. BNCEFNT may be useful in the treatment of some radioresistant brain tumors, such as glioblastoma multiforme. A neutron therapy beam for boron neutron capture enhanced fast neutron therapy has been developed for the existing Fermilab Neutron Therapy Facility. This beam produces a significant dose enhancement due to the the boron neutron capture reaction. The beam was developed by designing a filter and collimator system using the Monte Carlo radiation transport code, MCNPX. The MCNPX code was benchmarked against depth-dose measurements of the standard treatment beam. The new BNCEFNT beam is filtered with 18.3-cm of low carbon steel and is collimated with steel. Measurements of the dose enhancement of the new BNCEFNT beam were performed with paired tissue equivalent ion chambers. One of the ion chambers has boron incorporated in the wall of the chamber to measure the dose due to boron neutron capture. The measured boron dose enhancement of the BNCEFNT beam is (16.3 ± 2.6)% per 100-ppm 10B for a 20-cm diameter beam and (10.0 ± 1.6)% per 100-ppm 10B for a 10-cm diameter beam. The dose rate of the new beam is reduced to 4.4% of the dose rate of the standard treatment beam. xxi A conceptual design that overcomes the reduced dose rate is also presented. This design uses a tungsten collimator placed near the patient, with a 1.5-cm tungsten filter just upstream of the collimator. Using graphite moderation of neutrons around the patient a percent dose enhancement of 15% can be attained with good collimation, for field sizes as small as 5 × 5 cm2 , and without a reduction in dose rate.

  10. Analysis of Neutron Production in Passively Scattered Ion-Beam Therapy.

    Science.gov (United States)

    Heo, Seunguk; Yoo, Seunghoon; Song, Yongkeun; Kim, Eunho; Shin, Jaeik; Han, Soorim; Jung, Wongyun; Nam, Sanghee; Lee, Rena; Lee, Kitae; Cho, Sungho

    2017-07-01

    A new treatment facility for heavy ion therapy since 2010 was constructed. In the broad beam, a range shifter, ridge filter and multi leaf collimator (MLC) for the generation of the spread-out Bragg peak is used. In this case, secondary neutrons produced by the interactions of the ion field with beam-modifying devices (e.g. double-scattering system, beam shaping collimators and range compensators) are very important for patient safety. Therefore, these components must be carefully examined in the context of secondary neutron yield and associated secondary cancer risk. In this article, Monte Carlo simulation has been carried out with the FLUktuierende KAskade particle transport code, the fluence and distribution of neutron generation and the neutron dose equivalent from the broad beam components are compared using carbon and proton beams. As a result, it is confirmed that the yield of neutron production using a carbon beam from all components of the broad beam was higher than using a proton beam. The ambient dose by neutrons per heavy ion and proton ion from the MLC surface was 0.12-0.18 and 0.0067-0.0087 pSv, respectively, which shows that heavy ions generate more neutrons than protons. However, ambient dose per treatment 2 Gy, which means physical dose during treatment by ion beam, is higher than carbon beam because proton therapy needs more beam flux to make 2-Gy prescription dose. Therefore, the neutron production from the MLC, which is closed to the patient, is a very important parameter for patient safety. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  11. Analysis of neutron production in passively scattered ion-beam therapy

    International Nuclear Information System (INIS)

    Heo, Seunguk; Yoo, Seunghoon; Song, Yongkeun; Kim, Eunho; Shin, Jaeik; Han, Soorim; Wongyun Jung; Nam, Sanghee; Lee, Rena; Lee, Kitae; Cho, Sungho

    2017-01-01

    A new treatment facility for heavy ion therapy since 2010 was constructed. In the broad beam, a range shifter, ridge filter and multi leaf collimator (MLC) for the generation of the spread-out Bragg peak is used. In this case, secondary neutrons produced by the interactions of the ion field with beam-modifying devices (e.g. double-scattering system, beam shaping collimators and range compensators) are very important for patient safety. Therefore, these components must be carefully examined in the context of secondary neutron yield and associated secondary cancer risk. In this article, Monte Carlo simulation has been carried out with the FLUktuierende KAskade particle transport code, the fluence and distribution of neutron generation and the neutron dose equivalent from the broad beam components are compared using carbon and proton beams. As a result, it is confirmed that the yield of neutron production using a carbon beam from all components of the broad beam was higher than using a proton beam. The ambient dose by neutrons per heavy ion and proton ion from the MLC surface was 0.12 0.18 and 0.0067 0.0087 pSv, respectively, which shows that heavy ions generate more neutrons than protons. However, ambient dose per treatment 2 Gy, which means physical dose during treatment by ion beam, is higher than carbon beam because proton therapy needs more beam flux to make 2-Gy prescription dose. Therefore, the neutron production from the MLC, which is closed to the patient, is a very important parameter for patient safety. (authors)

  12. Salvage proton beam therapy in local recurrent uveal melanoma.

    Science.gov (United States)

    Riechardt, Aline I; Cordini, Dino; Dobner, Bianca; Seibel, Ira; Gundlach, Enken; Rehak, Matus; Hager, Annette; Stark, Roland; Moser, Lutz; Joussen, Antonia M

    2014-11-01

    To evaluate survival and ocular outcome in recurrent uveal melanoma treated with proton beam therapy as salvage therapy. Retrospective, interventional case series. We evaluated 48 patients with local recurrence of uveal melanoma after primary treatment with brachytherapy, transpupillary thermotherapy, proton beam therapy, laser photocoagulation, CyberKnife radiation, or photodynamic therapy. All patients received proton beam therapy as a salvage therapy at the Helmholtz Zentrum Berlin between July 2000 and December 2010. Kaplan-Meier analysis was used to obtain survival rates. The Kaplan-Meier estimator for local tumor control was 92.1% at 10 years after secondary treatment with proton beam therapy. Local recurrence developed in 3 patients; 1 of them underwent enucleation. During follow-up, 20.8% of the patients died (16.7% of metastasis, 4.1% of other causes or not specified). The most frequent surgical interventions were phacoemulsification (20.8%) and pars plana vitrectomy (10.4%). The Kaplan-Meier estimators were 77.4% for survival and 70.1% for the absence of metastasis 10 years after the primary treatment. Proton beam therapy as a salvage treatment resulted in high local tumor control rates in recurrent uveal melanoma, especially if the primary therapy was transpupillary thermotherapy or plaque brachytherapy. Preservation of the globe was possible in most patients. Enucleations were indicated only in case of re-recurrences of uveal melanoma, but not because of secondary complications like intractable pain or secondary glaucoma. Retreatment was associated with vision deterioration, but loss of vision remained exceptional. Further larger prospective studies are needed to confirm the presented results of our retrospective analysis. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. Treatment Planning for Ion Beam Therapy

    Science.gov (United States)

    Jäkel, Oliver

    The special aspects of treatment planning for ion beams are outlined in this chapter, starting with positioning and immobilization of the patient, describing imaging and segmentation, definition of treatment parameters, dose calculation and optimization, and, finally, plan assessment, verification, and quality assurance.

  14. The University of Texas M.D. Anderson Cancer Center Proton Therapy Facility

    International Nuclear Information System (INIS)

    Smith, Alfred; Newhauser, Wayne; Latinkic, Mitchell; Hay, Amy; Cox, James; McMaken, Bruce; Styles, John

    2003-01-01

    The University of Texas M.D. Anderson Cancer Center (MDACC), in partnership with Sanders Morris Harris Inc., a Texas-based investment banking firm, and The Styles Company, a developer and manager of hospitals and healthcare facilities, is building a proton therapy facility near the MDACC main complex at the Texas Medical Center in Houston, Texas USA. The MDACC Proton Therapy Center will be a freestanding, investor-owned radiation oncology center offering state-of-the-art proton beam therapy. The facility will have four treatment rooms: three rooms will have rotating, isocentric gantries and the fourth treatment room will have capabilities for both large and small field (e.g. ocular melanoma) treatments using horizontal beam lines. There will be an additional horizontal beam room dedicated to physics research and development, radiation biology research, and outside users who wish to conduct experiments using proton beams. The first two gantries will each be initially equipped with a passive scattering nozzle while the third gantry will have a magnetically swept pencil beam scanning nozzle. The latter will include enhancements to the treatment control system that will allow for the delivery of proton intensity modulation treatments. The proton accelerator will be a 250 MeV zero-gradient synchrotron with a slow extraction system. The facility is expected to open for patient treatments in the autumn of 2005. It is anticipated that 675 patients will be treated during the first full year of operation, while full capacity, reached in the fifth year of operation, will be approximately 3,400 patients per year. Treatments will be given up to 2-shifts per day and 6 days per week

  15. Study on external beam radiation therapy

    International Nuclear Information System (INIS)

    Kim, Mi Sook; Yoo, Seoung Yul; Yoo, Hyung Jun; Ji, Young Hoon; Lee, Dong Han; Lee, Dong Hoon; Choi, Mun Sik; Yoo, Dae Heon; Lee, Hyo Nam; Kim, Kyeoung Jung

    1999-04-01

    To develop the therapy technique which promote accuracy and convenience in external radiation therapy, to obtain the development of clinical treatment methods for the global competition. The contents of the R and D were 1. structure, process and outcome analysis in radiation therapy department. 2. Development of multimodality treatment in radiation therapy 3. Development of computation using networking techniques 4. Development of quality assurance (QA) system in radiation therapy 5. Development of radiotherapy tools 6. Development of intraoperative radiation therapy (IORT) tools. The results of the R and D were 1. completion of survey and analysis about Korea radiation therapy status 2. Performing QA analysis about ICR on cervix cancer 3. Trial of multicenter randomized study on lung cancers 4. Setting up inter-departmental LAN using MS NT server and Notes program 5. Development of ionization chamber and dose-rate meter for QA in linear accelerator 6. Development on optimized radiation distribution algorithm for multiple slice 7. Implementation on 3 dimensional volume surface algorithm and 8. Implementation on adaptor and cone for IORT

  16. Study on external beam radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Mi Sook; Yoo, Seoung Yul; Yoo, Hyung Jun; Ji, Young Hoon; Lee, Dong Han; Lee, Dong Hoon; Choi, Mun Sik; Yoo, Dae Heon; Lee, Hyo Nam; Kim, Kyeoung Jung

    1999-04-01

    To develop the therapy technique which promote accuracy and convenience in external radiation therapy, to obtain the development of clinical treatment methods for the global competition. The contents of the R and D were 1. structure, process and outcome analysis in radiation therapy department. 2. Development of multimodality treatment in radiation therapy 3. Development of computation using networking techniques 4. Development of quality assurance (QA) system in radiation therapy 5. Development of radiotherapy tools 6. Development of intraoperative radiation therapy (IORT) tools. The results of the R and D were 1. completion of survey and analysis about Korea radiation therapy status 2. Performing QA analysis about ICR on cervix cancer 3. Trial of multicenter randomized study on lung cancers 4. Setting up inter-departmental LAN using MS NT server and Notes program 5. Development of ionization chamber and dose-rate meter for QA in linear accelerator 6. Development on optimized radiation distribution algorithm for multiple slice 7. Implementation on 3 dimensional volume surface algorithm and 8. Implementation on adaptor and cone for IORT.

  17. Metrology and quality of radiation therapy dosimetry of electron, photon and epithermal neutron beams

    Energy Technology Data Exchange (ETDEWEB)

    Kosunen, A

    1999-08-01

    In radiation therapy using electron and photon beams the dosimetry chain consists of several sequential phases starting by the realisation of the dose quantity in the Primary Standard Dosimetry Laboratory and ending to the calculation of the dose to a patient. A similar procedure can be described for the dosimetry of epithermal neutron beams in boron neutron capture therapy (BNCT). To achieve the required accuracy of the dose delivered to a patient the quality of all steps in the dosimetry procedure has to be considered. This work is focused on two items in the dosimetry chains: the determination of the dose in the reference conditions and the evaluation of the accuracy of dose calculation methods. The issues investigated and discussed in detail are: a)the calibration methods of plane parallel ionisation chambers used in electron beam dosimetry, (b) the specification of the critical dosimetric parameter i.e. the ratio of stopping powers for water to air, (S I ?){sup water} {sub air}, in photon beams, (c) the feasibility of the twin ionization chamber technique for dosimetry in epithermal neutron beams applied to BNCT and (d) the determination accuracy of the calculated dose distributions in phantoms in electron, photon, and epithermal neutron beams. The results demonstrate that up to a 3% improvement in the consistency of dose determinations in electron beams is achieved by the calibration of plane parallel ionisation chambers in high energy electron beams instead of calibrations in {sup 60}Co gamma beams. In photon beam dosimetry (S I ?){sup water} {sub air} can be determined with an accuracy of 0.2% using the percentage dose at the 10 cm depth, %dd(10), as a beam specifier. The use of %odd(10) requires the elimination of the electron contamination in the photon beam. By a twin ionisation chamber technique the gamma dose can be determined with uncertainty of 6% (1 standard deviation) and the total neutron dose with an uncertainty of 15 to 20% (1 standard deviation

  18. Metrology and quality of radiation therapy dosimetry of electron, photon and epithermal neutron beams

    International Nuclear Information System (INIS)

    Kosunen, A.

    1999-08-01

    In radiation therapy using electron and photon beams the dosimetry chain consists of several sequential phases starting by the realisation of the dose quantity in the Primary Standard Dosimetry Laboratory and ending to the calculation of the dose to a patient. A similar procedure can be described for the dosimetry of epithermal neutron beams in boron neutron capture therapy (BNCT). To achieve the required accuracy of the dose delivered to a patient the quality of all steps in the dosimetry procedure has to be considered. This work is focused on two items in the dosimetry chains: the determination of the dose in the reference conditions and the evaluation of the accuracy of dose calculation methods. The issues investigated and discussed in detail are: a)the calibration methods of plane parallel ionisation chambers used in electron beam dosimetry, (b) the specification of the critical dosimetric parameter i.e. the ratio of stopping powers for water to air, (S I ?) water air , in photon beams, (c) the feasibility of the twin ionization chamber technique for dosimetry in epithermal neutron beams applied to BNCT and (d) the determination accuracy of the calculated dose distributions in phantoms in electron, photon, and epithermal neutron beams. The results demonstrate that up to a 3% improvement in the consistency of dose determinations in electron beams is achieved by the calibration of plane parallel ionisation chambers in high energy electron beams instead of calibrations in 60 Co gamma beams. In photon beam dosimetry (S I ?) water air can be determined with an accuracy of 0.2% using the percentage dose at the 10 cm depth, %dd(10), as a beam specifier. The use of %odd(10) requires the elimination of the electron contamination in the photon beam. By a twin ionisation chamber technique the gamma dose can be determined with uncertainty of 6% (1 standard deviation) and the total neutron dose with an uncertainty of 15 to 20% (1 standard deviation). To improve the accuracy

  19. Reliability analysis of minimum energy on target for laser facilities with more beam lines

    International Nuclear Information System (INIS)

    Chen Guangyu

    2008-01-01

    Shot reliability performance measures of laser facilities with more beam lines pertain to three categories: minimum-energy-on-target, power balance, and shot diagnostics. Accounting for symmetry of NIF beam line design and similarity of subset reliability in a same partition, a fault tree of meeting minimum-energy-on-target for the large laser facility shot of type K and a simplified method are presented, which are used to analyze hypothetic reliability of partition subsets in order to get trends of influences increasing number of beam lines and diverse shot types of large laser facilities on their shot reliability. Finally, it finds that improving component reliability is more crucial for laser facilities with more beam lines in comparison with those with beam lines and functional diversity from design flexibility is greatly helpful for improving shot reliability. (authors)

  20. Examination of Beryllium Under Intense High Energy Proton Beam at CERN's HiRadMat Facility

    CERN Document Server

    Ammigan, K.; Hurh, P.; Zwaska, R.; Atherton, A.; Caretta, O.; Davenne,T.; Densham, C.; Fitton, M.; Loveridge, P.; O'Dell, J.; Roberts, S.; Kuksenko, V.; Butcher, M.; Calviani, M.; Guinchard, M.; Losito, R.

    2017-01-01

    Beryllium is extensively used in various accelerator beam lines and target facilities as material for beam win- dows, and to a lesser extent, as secondary particle produc- tion targets. With increasing beam intensities of future ac- celerator facilities, it is critical to understand the response of beryllium under extreme conditions to avoid compro- mising particle production efficiency by limiting beam pa- rameters. As a result, the planned experiment at CERN’s HiRadMat facility will take advantage of the test facility’s tunable high intensity proton beam to probe and investigate the damage mechanisms of several grades of beryllium. The test matrix will consist of multiple arrays of thin discs of varying thicknesses as well as cylinders, each exposed to increasing beam intensities. Online instrumentations will acquire real time temperature, strain, and vibration data of the cylinders, while Post-Irradiation-Examination (PIE) of the discs will exploit advanced microstructural characteri- zation and imagin...

  1. Examination of Beryllium Under Intense High Energy Proton Beam at CERN's HiRadMat Facility

    CERN Document Server

    Ammigan, K; Hurh, P; Zwaska, R; Atherton, A; Caretta, O; Davenne, t; Densham, C; Fitton, M; Loveridge, P; O'Dell, J; Roberts, S; Kuksenko, v; Butcher, M; Calviani, M; Guinchard, M; Losito, R

    2015-01-01

    Beryllium is extensively used in various accelerator beam lines and target facilities as material for beam win- dows, and to a lesser extent, as secondary particle produc- tion targets. With increasing beam intensities of future ac- celerator facilities, it is critical to understand the response of beryllium under extreme conditions to avoid compro- mising particle production efficiency by limiting beam pa- rameters. As a result, the planned experiment at CERN’s HiRadMat facility will take advantage of the test facility’s tunable high intensity proton beam to probe and investigate the damage mechanisms of several grades of beryllium. The test matrix will consist of multiple arrays of thin discs of varying thicknesses as well as cylinders, each exposed to increasing beam intensities. Online instrumentations will acquire real time temperature, strain, and vibration data of the cylinders, while Post-Irradiation-Examination (PIE) of the discs will exploit advanced microstructural characteri- zation and imagin...

  2. Dosimetry of beams for negative pi-meson radiation therapy

    International Nuclear Information System (INIS)

    Dicello, J.F.

    1976-01-01

    Several new facilities have been built in the last few years which can produce high intensity beams of pions. As a result, a significant amount of new data related to pion dosimetry is available. Results of beam composition, beam shaping, and collimation are given along with depth dose curves and isodose contours. Experimental data which describe the radiation quality of pion beams and the change in radiation quality with position are presented. Experimental data determining the fraction of the dose resulting from neutrons are discussed. The present techniques used in pion dosimetry are summarized, and those areas of pion dosimetry which require additional effort in order to achieve routine treatment planning for patients are reviewed

  3. Therapy tumor with the heavy ions beam

    International Nuclear Information System (INIS)

    Dang Bingrong; Wei Zengquan; Li Wenjian

    2002-01-01

    As physical characteristic of heavy ions Bragg peak, therapy tumor with heavy ions is becoming advanced technology. So, many countries have developed the technology and used to treat tumor, the societal and economic effects are beneficial to people. The authors show the development, present situation and information of research in world of advanced radiotherapy with heavy ions

  4. An ion beam facility based on a 3 MV tandetron accelerator in Sichuan University, China

    Science.gov (United States)

    Han, Jifeng; An, Zhu; Zheng, Gaoqun; Bai, Fan; Li, Zhihui; Wang, Peng; Liao, Xiaodong; Liu, Mantian; Chen, Shunli; Song, Mingjiang; Zhang, Jun

    2018-03-01

    A new ion beam facility based on a 3 MV tandetron accelerator system has been installed in Sichuan University, China. The facility was developed by High Voltage Engineering Europa and consists of three high-energy beam lines including the ion beam analysis, ion implantation and nuclear physics experiment end stations, respectively. The terminal voltage stability of the accelerator is better than ±30 V, and the brightness of the proton beam is approximately 5.06 A/rad2/m2/eV. The system demonstrates a great application potential in fields such as nuclear, material and environmental studies.

  5. HiRadMat: A high‐energy, pulsed beam, material irradiation facility

    CERN Multimedia

    Charitonidis, Nikolaos

    2016-01-01

    HiRadMat is a facility constructed in 2011, designed to provide high-intensity pulsed beams to an irradiation area where different material samples or accelerator components can be tested. The facility, located at the CERN SPS accelerator complex, uses a 440 GeV proton beam with a pulse length up to 7.2 μs and a maximum intensity up to 1E13 protons / pulse. The facility, a unique place for performing state-of-the art beam-to-material experiments, operates under transnational access and welcomes and financially supports, under certain conditions, experimental teams to perform their experiments.

  6. Optimal Neutron Source and Beam Shaping Assembly for Boron Neutron Capture Therapy

    International Nuclear Information System (INIS)

    Vujic, J.; Greenspan, E.; Kastenber, W.E.; Karni, Y.; Regev, D.; Verbeke, J.M.; Leung, K.N.; Chivers, D.; Guess, S.; Kim, L.; Waldron, W.; Zhu, Y.

    2003-01-01

    There were three objectives to this project: (1) The development of the 2-D Swan code for the optimization of the nuclear design of facilities for medical applications of radiation, radiation shields, blankets of accelerator-driven systems, fusion facilities, etc. (2) Identification of the maximum beam quality that can be obtained for Boron Neutron Capture Therapy (BNCT) from different reactor-, and accelerator-based neutron sources. The optimal beam-shaping assembly (BSA) design for each neutron source was also to e obtained. (3) Feasibility assessment of a new neutron source for NCT and other medical and industrial applications. This source consists of a state-of-the-art proton or deuteron accelerator driving and inherently safe, proliferation resistant, small subcritical fission assembly

  7. Optimal Neutron Source and Beam Shaping Assembly for Boron Neutron Capture Therapy

    CERN Document Server

    Vujic, J L; Greenspan, E; Guess, S; Karni, Y; Kastenber, W E; Kim, L; Leung, K N; Regev, D; Verbeke, J M; Waldron, W L; Zhu, Y

    2003-01-01

    There were three objectives to this project: (1) The development of the 2-D Swan code for the optimization of the nuclear design of facilities for medical applications of radiation, radiation shields, blankets of accelerator-driven systems, fusion facilities, etc. (2) Identification of the maximum beam quality that can be obtained for Boron Neutron Capture Therapy (BNCT) from different reactor-, and accelerator-based neutron sources. The optimal beam-shaping assembly (BSA) design for each neutron source was also to e obtained. (3) Feasibility assessment of a new neutron source for NCT and other medical and industrial applications. This source consists of a state-of-the-art proton or deuteron accelerator driving and inherently safe, proliferation resistant, small subcritical fission assembly.

  8. A Monte Carlo code for ion beam therapy

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    Initially developed for applications in detector and accelerator physics, the modern Fluka Monte Carlo code is now used in many different areas of nuclear science. Over the last 25 years, the code has evolved to include new features, such as ion beam simulations. Given the growing use of these beams in cancer treatment, Fluka simulations are being used to design treatment plans in several hadron-therapy centres in Europe.   Fluka calculates the dose distribution for a patient treated at CNAO with proton beams. The colour-bar displays the normalized dose values. Fluka is a Monte Carlo code that very accurately simulates electromagnetic and nuclear interactions in matter. In the 1990s, in collaboration with NASA, the code was developed to predict potential radiation hazards received by space crews during possible future trips to Mars. Over the years, it has become the standard tool to investigate beam-machine interactions, radiation damage and radioprotection issues in the CERN accelerator com...

  9. Radioactive nuclear beam facilities based on projectile fragmentation

    International Nuclear Information System (INIS)

    Sherrill, B.M.

    1992-01-01

    The production of radioactive beams using direct separation techniques is discussed. The reaction mechanisms which can be used to produce radioactive beams with these techniques can be broadly divided into three groups, projectile fragmentation, nucleon transfer, and Coulomb disassociation. Radioactive nuclei produced in these ways have large forward momenta with relatively sharp angular distributions peaked near zero degrees which are suitable for collection with magnetic devices. Secondary beam intensities of up to a few percent of the primary beam intensity are possible, although depending on the production mechanism the beam emittance may be poor. Further beam purification can be achieved using atomic processes with profiled energy degraders. The features of the production reaction mechanism, separation techniques, and a review of world wide efforts are presented. The advantages and disadvantages of the method are presented, with discussion of techniques to overcome some of the disadvantages. (Author)

  10. Fault detection and protection system for neutral beam generators on the Neutral Beam Engineering Test Facility (NBETF)

    International Nuclear Information System (INIS)

    deVries, G.J.; Chesley, K.L.; Owren, H.M.

    1983-12-01

    Neutral beam sources, their power supplies and instrumentation can be damaged from high voltage sparkdown or from overheating due to excessive currents. The Neutral Beam Engineering Test Facility (NBETF) in Berkeley has protective electronic hardware that senses a condition outside a safe operating range and generates a response to terminate such a fault condition. A description of this system is presented in this paper. 8 references, 2 figures, 2 tables

  11. Beam brilliance investigation of high current ion beams at GSI heavy ion accelerator facility.

    Science.gov (United States)

    Adonin, A A; Hollinger, R

    2014-02-01

    In this work the emittance measurements of high current Ta-beam provided by VARIS (Vacuum Arc Ion Source) ion source are presented. Beam brilliance as a function of beam aperture at various extraction conditions is investigated. Influence of electrostatic ion beam compression in post acceleration gap on the beam quality is discussed. Use of different extraction systems (single aperture, 7 holes, and 13 holes) in order to achieve more peaked beam core is considered. The possible ways to increase the beam brilliance are discussed.

  12. Preparation of pediatric patients for treatment with proton beam therapy

    International Nuclear Information System (INIS)

    Mizumoto, Masashi; Oshiro, Yoshiko; Ayuzawa, Kaoru; Miyamoto, Toshio; Okumura, Toshiyuki; Fukushima, Takashi; Fukushima, Hiroko; Ishikawa, Hitoshi; Tsuboi, Koji; Sakurai, Hideyuki

    2015-01-01

    Purpose: Anesthesia is often used in proton beam therapy (PBT) for pediatric patients and this may prolong the treatment time. The aim of the study was to examine preparation of pediatric patients to allow smooth performance of PBT. Material and methods: Preparation was initiated 1–2 days before treatment planning CT and continued for 10 days. The patient first visited the facility to become familiar with the treatment room and staff. As the second step, the patient stayed in the treatment bed for a certain time with their mother, and then stayed on the treatment bed alone. Special fixtures painted with characters, music, and gifts were also prepared. Results: From 2010 to 2014, 111 pediatric patients underwent PBT. These patients were divided into 3 groups: 40 who could follow instructions well (group A, median age: 13.6 years old), 60 who could communicate, but found it difficult to stay alone for a long time (group B, median age: 4.6 years old), and 11 who could not follow instructions (group C, median age: 1.6 years old). Preparation was used for patients in group B. The mean treatment times in groups A, B and C were 13.6, 17.1, and 15.6 min, respectively, on PBT treatment days 2–6, and 11.8, 13.0, and 16.9 min, respectively, for the last 5 days of PBT treatment. The time reduction was significant in group B (p = 0.003). Conclusion: Preparation is useful for pediatric patients who can communicate. This approach allows PBT to be conducted more smoothly over a shorter treatment time

  13. Beta Beams: an accelerator based facility to explore Neutrino oscillation physics

    CERN Document Server

    Wildner, E; Hansen, C; De Melo Mendonca, T; Stora, T; Payet, J; Chance, A; Zorin, V; Izotov, I; Rasin, S; Sidorov, A; Skalyga, V; De Angelis, G; Prete, G; Cinausero, M; Kravchuk, VL; Gramegna, F; Marchi, T; Collazuol, G; De Rosa, G; Delbar, T; Loiselet, M; Keutgen, T; Mitrofanov, S; Lamy, T; Latrasse, L; Marie-Jeanne, M; Sortais, P; Thuillier, T; Debray, F; Trophime, C; Hass, M; Hirsh, T; Berkovits, D; Stahl, A

    2011-01-01

    The discovery that the neutrino changes flavor as it travels through space has implications for the Standard Model of particle physics (SM)[1]. To know the contribution of neutrinos to the SM, needs precise measurements of the parameters governing the neutrino oscillations. This will require a high intensity beam-based neutrino oscillation facility. The EURONu Design Study will review three currently accepted methods of realizing this facility (the so-called Super-Beams, Beta Beams and Neutrino Factories) and perform a cost assessment that, coupled with the physics performance, will give means to the European research authorities to make a decision on the layout and construction of the future European neutrino oscillation facility. ”Beta Beams” produce collimated pure electron neutrino and antineutrino beams by accelerating beta active ions to high energies and letting them decay in a race-track shaped storage ring. EURONu Beta Beams are based on CERNs infrastructure and the fact that some of the already ...

  14. Beam dynamics activities at the Thomas Jefferson National Accelerator Facility (Jefferson Lab)

    International Nuclear Information System (INIS)

    The Thomas Jefferson National Accelerator Facility (Jefferson Lab) has been funded by the US Navy to build an infra-red FEL driven by an energy-recovering compact SRF-based linear accelerator. The machine is to produce a 1 kW IR photon beam. The Jefferson Lab Accelerator Division is presently engaged in detailed design and beam dynamics studies for the driver accelerator. Principle beam dynamics and beam transport considerations include: (1) generation and transport of a high-quality, high-current, space-charge dominated beam; (2) the impact of coherent synchrotron radiation (CSR) during beam recirculation transport; (3) low-loss transport of a large momentum spread, high-current beam; (4) beam break up (BBU) instabilities in the recirculating accelerator; (5) impedance policing of transport system components; and (6) RF drive system control during energy recovery and FEL operation

  15. The ITER neutral beam test facility: Designs of the general infrastructure, cryosystem and cooling plant

    International Nuclear Information System (INIS)

    Cordier, J.J.; Hemsworth, R.; Chantant, M.; Gravil, B.; Henry, D.; Sabathier, F.; Doceul, L.; Thomas, E.; Houtte, D. van; Zaccaria, P.; Antoni, V.; Bello, S. Dal; Marcuzzi, D.; Antipenkov, A.; Day, C.; Dremel, M.; Mondino, P.L.

    2005-01-01

    The CEA Association is involved, in close collaboration with ENEA, FZK, IPP and UKAEA European Associations, in the first ITER neutral beam (NB) injector and the ITER neutral beam test facility design (EFDA task ref. TW3-THHN-IITF1). A total power of about 50 MW will have to be removed in steady state on the neutral beam test facility (NBTF). The main purpose of this task is to make progress with the detailed design of the first ITER NB injector and to start the conceptual design of the ITER NBTF. The general infrastructure layout of a generic site for the NBTF includes the test facility itself equipped with a dedicated beamline vessel [P.L. Zaccaria, et al., Maintenance schemes for the ITER neutral beam test facility, this conference] and integration studies of associated auxiliaries such as cooling plant, cryoplant and forepumping system

  16. Proton beam therapy how protons are revolutionizing cancer treatment

    CERN Document Server

    Yajnik, Santosh

    2013-01-01

    Proton beam therapy is an emerging technology with promise of revolutionizing the treatment of cancer. While nearly half of all patients diagnosed with cancer in the US receive radiation therapy, the majority is delivered via electron accelerators, where photons are used to irradiate cancerous tissue. Because of the physical properties of photon beams, photons may deposit energy along their entire path length through the body. On the other hand, a proton beam directed at a tumor travels in a straight trajectory towards its target, gives off most of its energy at a defined depth called the Bragg peak, and then stops. While photons often deposit more energy within the healthy tissues of the body than within the cancer itself, protons can deposit most of their cancer-killing energy within the area of the tumor. As a result, in the properly selected patients, proton beam therapy has the ability to improve cure rates by increasing the dose delivered to the tumor and simultaneously reduce side-effects by decreasing...

  17. The GSI plans for an international accelerator facility for beams of ions and antiprotons

    International Nuclear Information System (INIS)

    Suemmerer, K.

    2003-01-01

    GSI proposes to build a next-generation facility for research with relativistic beams of ions and antiprotons. This facility allows a broad range of topics in nuclear and astrophysics, plasma and atomic physics to be addressed. The topic most interesting in the context of this conference is physics with high-intensity beams of exotic nuclei. In addition, a short overview of the opportunities in the other fields of nuclear physics is given

  18. Unbunched beam electron-proton instability in the PSR and advanced hadron facilities

    International Nuclear Information System (INIS)

    Wang, Tai-Sen; Pisent, A.; Neuffer, D.V.

    1989-01-01

    We studied the possibility of the occurrence of transverse instability induced by trapped electrons in unbunched beams in the Proton Storage Ring and the proposed Advance Hadron Facility (AHF) at Los Alamos, as well as in the proposed Kaon Factory at TRIUMF. We found that the e-p instability may be possible for unbunched beams in the PSR but is unlikely to occur in the advanced hadron facilities. 8 refs., 4 figs

  19. Selected List of Low Energy Beam Transport Facilities for Light-Ion, High-Intensity Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Prost, L. R. [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States)

    2016-02-17

    This paper presents a list of Low Energy Beam Transport (LEBT) facilities for light-ion, high-intensity accelerators. It was put together to facilitate comparisons with the PXIE LEBT design choices. A short discussion regarding the importance of the beam perveance in the choice of the transport scheme follows.

  20. SPES: A new cyclotron-based facility for research and applications with high-intensity beams

    Science.gov (United States)

    Maggiore, M.; Campo, D.; Antonini, P.; Lombardi, A.; Manzolaro, M.; Andrighetto, A.; Monetti, A.; Scarpa, D.; Esposito, J.; Silvestrin, L.

    2017-06-01

    In 2016, Laboratori Nazionali di Legnaro (Italy) started the commissioning of a new accelerator facility based on a high-power cyclotron able to deliver proton beams up to 70 MeV of energy and 700 μA current. Such a machine is the core of the Selective Production of Exotic Species (SPES) project whose main goal is to provide exotics beam for nuclear and astrophysics research and to deliver high-intensity proton beams for medical applications and neutrons generator.

  1. Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy.

    Science.gov (United States)

    Allen, Christopher; Borak, Thomas B; Tsujii, Hirohiko; Nickoloff, Jac A

    2011-06-03

    Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilities, particle therapy has shown improved cancer survival rates, reflecting more highly focused dose distributions and more severe DNA damage to tumor cells. Despite early successes of charged particle radiotherapy, there is room for further improvement, and much remains to be learned about normal and cancer cell responses to charged particle radiation. 2011 Elsevier B.V. All rights reserved.

  2. Experiments and FLUKA simulations of $^{12}C$ and $^{16}O$ beams for therapy monitoring by means of in-beam Positron Emission Tomography

    CERN Document Server

    Sommerer,; Ferrari, A

    2007-01-01

    Since 1997 at the experimental C-12 ion therapy facility at Gesellschaft fuer Schwerionenforschung (GSI), Darmstadt, Germany, more than 350 patients have been treated. The therapy is monitored with a dedicated positron emission tomograph, fully integrated into the treatment site. The measured beta+-activity arises from inelastic nuclear interactions between the beam particles an the nuclei of the patients tissue. Because the monitoring is done during the irradiation the method is called in-beam PET. The underlying principle of this monitoring is a comparison between the measured activity and a simulated one. The simulations are presently done by the PETSIM code which is dedicated to C-12 beams. In future ion therapy centers like the Heidelberger Ionenstrahl Therapiezentrum (HIT), Heidelberg, Germany, besides C-12 also proton, $^3$He and O-16 beams will be used for treatment and the therapy will be monitored by means of in-beam PET. Because PETSIM is not extendable to other ions in an easy way, a code capable ...

  3. 21 CFR 892.5710 - Radiation therapy beam-shaping block.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Radiation therapy beam-shaping block. 892.5710... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Therapeutic Devices § 892.5710 Radiation therapy beam-shaping block. (a) Identification. A radiation therapy beam-shaping block is a device made of a highly...

  4. Nano-scale processes behind ion-beam cancer therapy

    Science.gov (United States)

    Surdutovich, Eugene; Garcia, Gustavo; Mason, Nigel; Solov'yov, Andrey V.

    2016-04-01

    This topical issue collates a series of papers based on new data reported at the third Nano-IBCT Conference of the COST Action MP1002: Nanoscale Insights into Ion Beam Cancer Therapy, held in Boppard, Germany, from October 27th to October 31st, 2014. The Nano-IBCT COST Action was launched in December 2010 and brought together more than 300 experts from different disciplines (physics, chemistry, biology) with specialists in radiation damage of biological matter from hadron-therapy centres, and medical institutions. This meeting followed the first and the second conferences of the Action held in October 2011 in Caen, France and in May 2013 in Sopot, Poland respectively. This conference series provided a focus for the European research community and has highlighted the pioneering research into the fundamental processes underpinning ion beam cancer therapy. Contribution to the Topical Issue "COST Action Nano-IBCT: Nano-scale Processes Behind Ion-Beam Cancer Therapy", edited by Andrey V. Solov'yov, Nigel Mason, Gustavo Garcia and Eugene Surdutovich.

  5. Conceptual design of beam dividing system for J-PARC Transmutation Experimental Facility

    International Nuclear Information System (INIS)

    Yoshimoto, Masahiro; Okabe, Kota; Kinsho, Michikazu

    2015-01-01

    At the Japan Proton Accelerator Research Complex, a new experimental facility called the Transmutation Experimental Facility (TEF) is planned for the Accelerator-Driven System. The TEF facility will use the 400 MeV proton beam from the LINAC, which requires introducing a beam dividing system at a Beam Transport from the LINAC to the 3 GeV Rapid Cycling Synchrotron (RCS). However, an early feasibility study indicates that sufficient beam orbit separation is difficult to obtain at the doublet with only a pulsed bending magnet. Therefore, the beam for the TEF is extracted by using both the pulsed bending magnet and a static septum magnet. To optimize this two-step beam extraction scheme, the doublet quadrupole magnets should be improved. Moreover, the residual field of the pulse bending magnet at zero current should be corrected. By studying every possible scheme for the beam dividing system under current conditions, we expect to obtain a realistic design for the beam dividing system. In this paper, we introduce a conceptual design of the beam dividing system that is based on resent results of studies of realistic designs. (author)

  6. The Monte Carlo simulation of the Ladon photon beam facility

    International Nuclear Information System (INIS)

    Strangio, C.

    1976-01-01

    The backward compton scattering of laser light against high energy electrons has been simulated with a Monte Carlo method. The main features of the produced photon beam are reported as well as a careful description of the numerical calculation

  7. Study on beam geometry and image reconstruction algorithm in fast neutron computerized tomography at NECTAR facility

    Energy Technology Data Exchange (ETDEWEB)

    Guo, J. [State Key Laboratory of Nuclear Physics and Technology and School of Physics, Peking University, 5 Yiheyuan Lu, Beijing 100871 (China); Lehrstuhl fuer Radiochemie, Technische Universitaet Muenchen, Garching 80748 (Germany); Buecherl, T. [Lehrstuhl fuer Radiochemie, Technische Universitaet Muenchen, Garching 80748 (Germany); Zou, Y., E-mail: zouyubin@pku.edu.cn [State Key Laboratory of Nuclear Physics and Technology and School of Physics, Peking University, 5 Yiheyuan Lu, Beijing 100871 (China); Guo, Z. [State Key Laboratory of Nuclear Physics and Technology and School of Physics, Peking University, 5 Yiheyuan Lu, Beijing 100871 (China)

    2011-09-21

    Investigations on the fast neutron beam geometry for the NECTAR facility are presented. The results of MCNP simulations and experimental measurements of the beam distributions at NECTAR are compared. Boltzmann functions are used to describe the beam profile in the detection plane assuming the area source to be set up of large number of single neutron point sources. An iterative algebraic reconstruction algorithm is developed, realized and verified by both simulated and measured projection data. The feasibility for improved reconstruction in fast neutron computerized tomography at the NECTAR facility is demonstrated.

  8. The Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Garrett, J.D.

    1996-01-01

    The status of the new Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory (ORNL), which is slated to start its scientific program late this year is discussed, as is the new experimental equipment which is being constructed at this facility. Information on the early scientific program also is given

  9. Accelerator Based Neutron Beams for Neutron Capture Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Yanch, Jacquelyn C.

    2003-04-11

    The DOE-funded accelerator BNCT program at the Massachusetts Institute of Technology has resulted in the only operating accelerator-based epithermal neutron beam facility capable of generating significant dose rates in the world. With five separate beamlines and two different epithermal neutron beam assemblies installed, we are currently capable of treating patients with rheumatoid arthritis in less than 15 minutes (knee joints) or 4 minutes (finger joints) or irradiating patients with shallow brain tumors to a healthy tissue dose of 12.6 Gy in 3.6 hours. The accelerator, designed by Newton scientific Incorporated, is located in dedicated laboratory space that MIT renovated specifically for this project. The Laboratory for Accelerator Beam Applications consists of an accelerator room, a control room, a shielded radiation vault, and additional laboratory space nearby. In addition to the design, construction and characterization of the tandem electrostatic accelerator, this program also resulted in other significant accomplishments. Assemblies for generating epithermal neutron beams were designed, constructed and experimentally evaluated using mixed-field dosimetry techniques. Strategies for target construction and target cooling were implemented and tested. We demonstrated that the method of submerged jet impingement using water as the coolant is capable of handling power densities of up to 6 x 10(sup 7) W/m(sup 2) with heat transfer coefficients of 10(sup 6)W/m(sup 2)-K. Experiments with the liquid metal gallium demonstrated its superiority compared with water with little effect on the neutronic properties of the epithermal beam. Monoenergetic proton beams generated using the accelerator were used to evaluate proton RBE as a function of LET and demonstrated a maximum RBE at approximately 30-40 keV/um, a finding consistent with results published by other researchers. We also developed an experimental approach to biological intercomparison of epithermal beams and

  10. Trabeculectomy in patients with uveal melanoma after proton beam therapy.

    Science.gov (United States)

    Riechardt, Aline I; Cordini, Dino; Rehak, Matus; Hager, Annette; Seibel, Ira; Böker, Alexander; Gundlach, Enken; Heufelder, Jens; Joussen, Antonia M

    2016-07-01

    Retrospective evaluation of intraocular pressure, use of topical and systemic anti-glaucoma medication, secondary complications, local tumor control and survival in patients treated with trabeculectomy for the regulation of the intraocular pressure (IOP) after proton beam therapy for uveal melanoma. In this retrospective clinical case series we evaluated the follow-up of 15 patients receiving a trabeculectomy as surgical treatment if the IOP could not be lowered adequately by medications or laser surgery. All patients had received proton beam therapy for uveal melanoma at the Helmholtz-Zentrum Berlin between 1998 and 2010. The median IOP decreased significantly from 35 mmHg ± 8.8 before TE to 16 mmHg ± 8.2 (=52.3 %) six months after TE (Wilcoxon-Mann-Whitney-U Test, p<0.01). None of the patients needed any glaucoma medication six months after trabeculectomy. Two patients developed local recurrence during follow-up, which were independent of the trabeculectomy. One patient had to be enucleated due to intractable pain and suspected remaining tumor activity. One patient died due to metastasis. Trabeculectomy is an option in intractable glaucoma in patients with uveal melanoma after proton beam therapy in single cases. Secondary interventions are common. Inoculation metastases are possible. Secure local tumor control must be a prerequisite for filtrating operations.

  11. European research activities on charge state breeding related to radioactive ion beam facilities.

    Science.gov (United States)

    Lamy, T; Angot, J; Thuillier, T

    2008-02-01

    European effort on charge breeders is mainly dedicated to present and future Radioactive Ion Beam facilities. The main projects are High Intensity and Energy-ISOLDE at CERN, SPIRAL2 at GANIL, and EURISOL. Most of the experimental developments are funded by the European programs EURONS (European Nuclear Structure) and EURISOL (European Isotope Separation On-Line Radioactive Ion Beam Facility). Two ion source types (electron beam ion source and electron cyclotron resonance ion source) have been adapted to accept the injection and the capture of an ion beam, in order to increase its charge with the highest efficiency within the shortest time. Both charge breeders have advantages and disadvantages with regard to their use in a Radioactive Ion Beam facility. The most important parameters studied are acceptance (in emittance and intensity) of the charge breeder, efficiency, and charge breeding time of a specific n+ charge state, emittance of the extracted n+ beam. The charge breeder parameters are studied with different 1+ ion sources dedicated to 1+ radioactive ion beam production, and the tuning procedure of the charge breeder as a beam line section of a specific accelerator is established and measured too.

  12. Beam studies and experimental facility for the AWAKE experiment at CERN

    International Nuclear Information System (INIS)

    Bracco, Chiara; Gschwendtner, Edda; Petrenko, Alexey; Timko, Helga; Argyropoulos, Theodoros; Bartosik, Hannes; Bohl, Thomas; Esteban Müller, Juan; Goddard, Brennan; Meddahi, Malika; Pardons, Ans; Shaposhnikova, Elena; Velotti, Francesco M.; Vincke, Helmut

    2014-01-01

    A Proton Driven Plasma Wakefield Acceleration Experiment has been proposed as an approach to eventually accelerate an electron beam to the TeV energy range in a single plasma section. To verify this novel technique, a proof of principle R and D experiment, AWAKE, is planned at CERN using 400 GeV proton bunches from the SPS. An electron beam will be injected into the plasma cell to probe the accelerating wakefield. The AWAKE experiment will be installed in the CNGS facility profiting from existing infrastructure where only minor modifications need to be foreseen. The design of the experimental area and the proton and electron beam lines are shown. The achievable SPS proton bunch properties and their reproducibility have been measured and are presented. - Highlights: • A proton driven plasma wakefield experiment using the first time protons as drive beam is proposed. • The integration of AWAKE experiment, the proton, laser and electron beam line in an existing CERN facility is demonstrated. • The necessary modifications in the experimental facility are presented. • Proton beam optics and a new electron beam line are adapted to match with the required beam parameters. • Short high-intensity bunches were studied in the SPS to guide the design parameters of the AWAKE project

  13. Commissioning experience and beam physics measurements at the SwissFEL Injector Test Facility

    Directory of Open Access Journals (Sweden)

    T. Schietinger

    2016-10-01

    Full Text Available The SwissFEL Injector Test Facility operated at the Paul Scherrer Institute between 2010 and 2014, serving as a pilot plant and test bed for the development and realization of SwissFEL, the x-ray Free-Electron Laser facility under construction at the same institute. The test facility consisted of a laser-driven rf electron gun followed by an S-band booster linac, a magnetic bunch compression chicane and a diagnostic section including a transverse deflecting rf cavity. It delivered electron bunches of up to 200 pC charge and up to 250 MeV beam energy at a repetition rate of 10 Hz. The measurements performed at the test facility not only demonstrated the beam parameters required to drive the first stage of an FEL facility, but also led to significant advances in instrumentation technologies, beam characterization methods and the generation, transport and compression of ultralow-emittance beams. We give a comprehensive overview of the commissioning experience of the principal subsystems and the beam physics measurements performed during the operation of the test facility, including the results of the test of an in-vacuum undulator prototype generating radiation in the vacuum ultraviolet and optical range.

  14. ISAC and ARIEL the TRIUMF radioactive beam facilities and the scientific program

    CERN Document Server

    Krücken, Reiner; Merminga, Lia

    2014-01-01

    The TRIUMF Isotope Separator and Accelerator (ISAC) facility uses the isotope separation on-line (ISOL) technique to produce rare-isotope beams (RIB). The ISOL system consists of a primary production beam, a target/ion source, a mass separator, and beam transport system. The rare isotopes produced during the interaction of the proton beam with the target nucleus are stopped in the bulk of the target material. They diffuse inside the target material matrix to the surface of the grain and then effuse to the ion source where they are ionized to form an ion beam that can be separated by mass and then guided to the experimental facilities. Previously published in the journal Hyperfine Interactions.

  15. Two frequency beam-loading compensation in the drive-beam accelerator of the CLIC Test Facility

    CERN Document Server

    Braun, Hans Heinrich

    1999-01-01

    The CLIC Test Facility (CTF) is a prototype two-beam accelerator, in which a high-current "drive beam" is used to generate the RF power for the main-beam accelerator. The drive-beam accelerator consists of two S-band structures which accelerate a bunch train with a total charge of 500 nC. The substantial beam loading is compensated by operating the two accelerating structures at 7.81 MHz above and below the bunch repetition frequency, respectively. This introduces a change of RF phase from bunch to bunch, which leads, together with off-crest injection into the accelerator, to an approximate compensation of the beam loading. Due to the sinusoidal time-dependency of the RF field, an energy spread of about 7% remains in the bunch train. A set of idler cavities has been installed to reduce this residual energy spread further. In this paper, the considerations that motivated the choice of the parameters of the beam-loading compensation system, together with the experimental results, are presented.

  16. Beam-on imaging of short-lived positron emitters during proton therapy

    Science.gov (United States)

    Buitenhuis, H. J. T.; Diblen, F.; Brzezinski, K. W.; Brandenburg, S.; Dendooven, P.

    2017-06-01

    In vivo dose delivery verification in proton therapy can be performed by positron emission tomography (PET) of the positron-emitting nuclei produced by the proton beam in the patient. A PET scanner installed in the treatment position of a proton therapy facility that takes data with the beam on will see very short-lived nuclides as well as longer-lived nuclides. The most important short-lived nuclide for proton therapy is 12N (Dendooven et al 2015 Phys. Med. Biol. 60 8923-47), which has a half-life of 11 ms. The results of a proof-of-principle experiment of beam-on PET imaging of short-lived 12N nuclei are presented. The Philips Digital Photon Counting Module TEK PET system was used, which is based on LYSO scintillators mounted on digital SiPM photosensors. A 90 MeV proton beam from the cyclotron at KVI-CART was used to investigate the energy and time spectra of PET coincidences during beam-on. Events coinciding with proton bunches, such as prompt gamma rays, were removed from the data via an anti-coincidence filter with the cyclotron RF. The resulting energy spectrum allowed good identification of the 511 keV PET counts during beam-on. A method was developed to subtract the long-lived background from the 12N image by introducing a beam-off period into the cyclotron beam time structure. We measured 2D images and 1D profiles of the 12N distribution. A range shift of 5 mm was measured as 6  ±  3 mm using the 12N profile. A larger, more efficient, PET system with a higher data throughput capability will allow beam-on 12N PET imaging of single spots in the distal layer of an irradiation with an increased signal-to-background ratio and thus better accuracy. A simulation shows that a large dual panel scanner, which images a single spot directly after it is delivered, can measure a 5 mm range shift with millimeter accuracy: 5.5  ±  1.1 mm for 1  ×  108 protons and 5.2  ±  0.5 mm for 5  ×  108 protons. This makes

  17. Performance of the Culham multi-megawatt beam line facility

    Energy Technology Data Exchange (ETDEWEB)

    Hammond, D.P.; Cottrell, G.A.; Coupland, J.R.

    1981-01-01

    The Culham Megawatt Beam Line has been upgraded in order to test injector modules for the JET experiment. The major items provided are: a high voltage modulator tube system, modified auxiliary supplies, new vacuum tanks and cryopumps, a high power beam pump, additional tanks and cryopumps, a high power data acquisition system. Delivery of the first complete JET prototype source and accelerator was scheduled for the end of 1981. The major components, having been tested separately as far as possible, are now installed and are being tested up to the 80kV, 12A level of the existing plasma source.

  18. Performance of the Culham multi-megawatt beam line facility

    International Nuclear Information System (INIS)

    Hammond, D.P.; Cottrell, G.A.; Coupland, J.R.

    1981-01-01

    The Culham Megawatt Beam Line has been upgraded in order to test injector modules for the JET experiment. The major items provided are: a high voltage modulator tube system, modified auxiliary supplies, new vacuum tanks and cryopumps, a high power beam pump, additional tanks and cryopumps, a high power data acquisition system. Delivery of the first complete JET prototype source and accelerator was scheduled for the end of 1981. The major components, having been tested separately as far as possible, are now installed and are being tested up to the 80kV, 12A level of the existing plasma source

  19. Construction of the Neutron Beam Facility at Australia's OPAL Research Reactor

    International Nuclear Information System (INIS)

    Kennedy, J.S.

    2005-01-01

    Full text: Australia's new research reactor, OPAL, has been designed for high quality neutron beam science and radioisotope production. It has a capacity for eighteen neutron beam instruments to be located at the reactor face and in a neutron guide hall. The new neutron beam facility features a 20 litre liquid deuterium cold neutron source and supermirror neutron reflecting guides for intense cold and thermal neutron beams. Nine neutron beam instruments are under development, of which seven are scheduled for completion in early 2007. The project is approaching the hot-commissioning stage, where criticality will be demonstrated. Installation of the neutron beam transport system and neutron beam instruments in the neutron guide hall and at the reactor face is underway, and the path to completion of this project is relatively clear. The lecture will outline Australia's aspirations for neutron science at the OPAL reactor, and describe the neutron beam facility under construction. The status of this project and a forecast of the program to completion, including commissioning and commencement of routine operation in 2007 will also be discussed. This project is the culmination of almost a decade of effort. We now eagerly anticipate catapulting Australia's neutron beam science capability to meet the best in the world today. (author)

  20. Optics calculations and beam line design for the JANNuS facility in Orsay

    Science.gov (United States)

    Chauvin, N.; Henry, S.; Flocard, H.; Fortuna, F.; Kaitasov, O.; Pariset, P.; Pellegrino, S.; Ruault, M. O.; Serruys, Y.; Trocelier, P.

    2007-08-01

    JANNuS (Joint Accelerators for Nano-Science and Nuclear Simulation) will be a unique user facility in Europe dedicated to material modification by ion beam implantation and irradiation. The main originality of the project is that it will be possible to perform implantation and irradiation with simultaneous multiple ions beams and in situ characterization by transmission electron microscopy (TEM) observation or ion beam analysis. This facility will be composed of two experimental platforms located in two sites: the CEA-SRMP in Saclay and the CNRS-CSNSM in Orsay. This paper will focus on the design of two new transport beam lines for the Orsay site. One of the most challenging parts of the JANNuS project (Orsay site) is to design two new beam lines in order to inject, into a 200 kV TEM, two different ion beams (low and medium energy) coming from two existing pieces of equipment: a 2 MV Tandem accelerator and a 190 kV ion implanter. For these new beam lines, first order beam calculations have been done using transfer matrix formalism. A genetic algorithm has been written and adapted to perform the optimization of the beam line parameters. Then, using the SIMION code, field maps of the electrostatic elements (quadrupoles, spherical sectors) have been calculated and ion trajectories have been simulated. We studied specifically the optical aberrations induced by the electrostatic spherical deflectors. Finally, the results of the first order calculations and the field map simulations show a good agreement.

  1. Optics calculations and beam line design for the JANNuS facility in Orsay

    International Nuclear Information System (INIS)

    Chauvin, N.; Henry, S.; Flocard, H.; Fortuna, F.; Kaitasov, O.; Pariset, P.; Pellegrino, S.; Ruault, M.O.; Serruys, Y.; Trocelier, P.

    2007-01-01

    JANNuS (Joint Accelerators for Nano-Science and Nuclear Simulation) will be a unique user facility in Europe dedicated to material modification by ion beam implantation and irradiation. The main originality of the project is that it will be possible to perform implantation and irradiation with simultaneous multiple ions beams and in situ characterization by transmission electron microscopy (TEM) observation or ion beam analysis. This facility will be composed of two experimental platforms located in two sites: the CEA-SRMP in Saclay and the CNRS-CSNSM in Orsay. This paper will focus on the design of two new transport beam lines for the Orsay site. One of the most challenging parts of the JANNuS project (Orsay site) is to design two new beam lines in order to inject, into a 200 kV TEM, two different ion beams (low and medium energy) coming from two existing pieces of equipment: a 2 MV Tandem accelerator and a 190 kV ion implanter. For these new beam lines, first order beam calculations have been done using transfer matrix formalism. A genetic algorithm has been written and adapted to perform the optimization of the beam line parameters. Then, using the SIMION code, field maps of the electrostatic elements (quadrupoles, spherical sectors) have been calculated and ion trajectories have been simulated. We studied specifically the optical aberrations induced by the electrostatic spherical deflectors. Finally, the results of the first order calculations and the field map simulations show a good agreement

  2. ISABELLE: a 200 + 200 GeV colliding beam facility

    International Nuclear Information System (INIS)

    Courant, E.D.

    1977-01-01

    Plans are under way for the construction of a pair of intersecting storage rings providing for colliding beams of protons of energy at least 200 GeV. The rings (circumference 2.62 km) will contain superconducting magnets constructed with braided Nb--Ti filamentary wire, with a peak field of 4.0 T corresponding to an energy of 200 GeV. A current of 10 A of protons will be injected at 29 GeV from the existing AGS accelerator at Brookhaven, using the energy stacking technique similar to that employed at the CERN ISR; subsequently the stored beam will be accelerated gradually in the storage rings. Six intersection areas will be provided for experiments. They are designed to provide flexibility in beam characteristics for different experiments. The maximum luminosity at full energy is expected to be 1.0 x 10 33 cm -2 s -1 , at 29 GeV it will be approximately 10 32 cm -2 s -1 . Recent work with prototype magnets indicates that fields of 5.0 T can be produced. This has led to an alternative design of somewhat larger rings (circumference 3.77 km) that should be capable of providing colliding beams at 400 + 400 GeV

  3. Dosimetric consequences of pencil beam width variations in scanned beam particle therapy

    International Nuclear Information System (INIS)

    Chanrion, M A; Ammazzalorso, F; Wittig, A; Engenhart-Cabillic, R; Jelen, U

    2013-01-01

    Scanned ion beam delivery enables the highest degree of target dose conformation attainable in external beam radiotherapy. Nominal pencil beam widths (spot sizes) are recorded during treatment planning system commissioning. Due to changes in the beam-line optics, the actual spot sizes may differ from these commissioning values, leading to differences between planned and delivered dose. The purpose of this study was to analyse the dosimetric consequences of spot size variations in particle therapy treatment plans. For 12 patients with skull base tumours and 12 patients with prostate carcinoma, scanned-beam carbon ion and proton treatment plans were prepared and recomputed simulating spot size changes of (1) ±10% to simulate the typical magnitude of fluctuations, (2) ±25% representing the worst-case scenario and (3) ±50% as a part of a risk analysis in case of fault conditions. The primary effect of the spot size variation was a dose deterioration affecting the target edge: loss of target coverage and broadening of the lateral penumbra (increased spot size) or overdosage and contraction of the lateral penumbra (reduced spot size). For changes ⩽25%, the resulting planning target volume mean 95%-isodose line coverage (CI-95%) deterioration was ranging from negligible to moderate. In some cases changes in the dose to adjoining critical structures were observed. (paper)

  4. Commissioning experience and beam physics measurements at the SwissFEL Injector test Facility

    CERN Document Server

    Schietinger, T.; Aiba, M.; Arsov, V.; Bettoni, S.; Beutner, B.; Calvi, M.; Craievich, P.; Dehler, M.; Frei, F.; Ganter, R.; Hauri, C. P.; Ischebeck, R.; Ivanisenko, Y.; Janousch, M.; Kaiser, M.; Keil, B.; Löhl, F.; Orlandi, G. L.; Ozkan Loch, C.; Peier, P.; Prat, E.; Raguin, J.-Y.; Reiche, S.; Schilcher, T.; Wiegand, P.; Zimoch, E.; Anicic, D.; Armstrong, D.; Baldinger, M.; Baldinger, R.; Bertrand, A.; Bitterli, K.; Bopp, M.; Brands, H.; Braun, H. H.; Brönnimann, M.; Brunnenkant, I.; Chevtsov, P.; Chrin, J.; Citterio, A.; Csatari Divall, M.; Dach, M.; Dax, A.; Ditter, R.; Divall, E.; Falone, A.; Fitze, H.; Geiselhart, C.; Guetg, M. W.; Hämmerli, F.; Hauff, A.; Heiniger, M.; Higgs, C.; Hugentobler, W.; Hunziker, S.; Janser, G.; Kalantari, B.; Kalt, R.; Kim, Y.; Koprek, W.; Korhonen, T.; Krempaska, R.; Laznovsky, M.; Lehner, S.; Le Pimpec, F.; Lippuner, T.; Lutz, H.; Mair, S.; Marcellini, F.; Marinkovic, G.; Menzel, R.; Milas, N.; Pal, T.; Pollet, P.; Portmann, W.; Rezaeizadeh, A.; Ritt, S.; Rohrer, M.; Schär, M.; Schebacher, L.; Scherrer, St.; Schlott, V.; Schmidt, T.; Schulz, L.; Smit, B.; Stadler, M.; Steffen, Bernd; Stingelin, L.; Sturzenegger, W.; Treyer, D. M.; Trisorio, A.; Tron, W.; Vicario, C.; Zennaro, R.; Zimoch, D.

    2016-10-26

    The SwissFEL Injector Test Facility operated at the Paul Scherrer Institute between 2010 and 2014, serving as a pilot plant and test bed for the development and realization of SwissFEL, the x-ray Free Electron Laser facility under construction at the same institute. The test facility consisted of a laser-driven rf electron gun followed by an S-band booster linac, a magnetic bunch compression chicane and a diagnostic section including atransverse deflecting rf cavity. It delivered electron bunchesof up to200 pC chargeand up to 250 MeV beam energy at a repetition rate of 10 Hz. The measurements performed at the test facility not only demonstrated the beam parameters required to drive the first stage of a FEL facility, but also led to significant advances in instrumentation technologies, beam characterization methods and the generation, transport and compression of ultralow-emittance beams. We give a comprehensive overview of the commissioning experience of the principal subsystems and the beam physics measureme...

  5. Plasma heating by high-energy-content microsecond electron beam at the GOL-3-II facility

    International Nuclear Information System (INIS)

    Agafonov, M.A.; Arzhannikov, A.V.; Astrelin, V.T.

    1996-01-01

    A description of the GOL-3-II facility and the first experimental results obtained on this new device are presented. This facility was constructed as part of the second stage of the GOL-3 programme for studying the interaction of microsecond electron beams with a plasma and its fast heating. The plasma column of the GOL-3-II facility is 12 m in length instead of 7 m for the first stage of GOL-3. The energy content of the capacity storage for magnetic field supply has been increased from 10 MJ to 15 MJ. This allows us to have a magnetic field of up to 5 T in the homogeneous part of the solenoid and up to 10 T in its end mirrors. The expected key feature of the upgrading is an essential increase in the energy content of the electron beam injected into the plasma. The high-power electron beam generator U-2 is now used for the new beam-plasma interaction experiments with possible beam energy content of up to 0.3 MJ. It is shown experimentally that transportation of a 0.2 MJ electron beam through the 12 m plasma column is possible under conditions of almost full current neutralization. The collective beam-plasma interaction results in a plasma heting of up to 1-2 keV electron temperature at ∼ 10 15 cm -3 density. (author)

  6. SU-E-T-626: Practical Method to Implement Arc Therapy Using Scanned Particle Beams

    Energy Technology Data Exchange (ETDEWEB)

    Eley, J; Mehta, M; Molitoris, J; Langner, U; Langen, K [University of Maryland School of Medicine, Baltimore, MD (United States)

    2015-06-15

    Purpose: The purpose of this study was to propose a method to implement arc therapy that is compatible with existing particle therapy systems having gantries and pencil-beam scanning capacities. Furthermore, we sought to demonstrate expected benefits of this method for selected clival chordoma patients. Methods: We propose that a desired particle arc treatment plan can be discretized into a finite number of fixed beams and that only one (or a subset) of these beams be delivered in any single treatment fraction; the target should receive uniform dose during each fraction. For 3 clival-chordoma patients, robust-optimized, scanned proton beams were simulated to deliver 78 Gy (RBE) to clinical target volumes (CTVs), using either a single-field plan with a posterior-anterior (PA) beam or a discrete-arc plan with 16 beams that were equally spaced throughout a 360-degree axial arc. Dose-volume metrics were compared with emphasis on the brainstem, since risk of radiation necrosis there can often restrict application of tumoricidal doses for chordomas. Results: The mean volume of brainstem receiving a dose of 60 Gy (RBE) or higher (V60Gy) was 10.3±0.9 cm{sup 3} for the single-field plan and 4.7±1.8 cm{sup 3} for the discrete-arc plan, a reduction of 55% in favor of arcs. The mean dose to the brainstem was also reduced using arcs, by 18%, while the maximum dose was nearly identical for both methods. For the whole brain, V60Gy was reduced by 23%, in favor of arcs. Mean dose to the CTVs were nearly identical for both strategies, within 0.3%. Conclusion: Discrete arc treatments can be implemented using existing scanned particle-beam facilities. Aside from the physical advantages, the biological uncertainties of particle therapy, particularly high in the distal edge, can be reduced by arc therapy via rotational smearing, which may be of benefit for tumors near the brainstem.

  7. A large area diamond-based beam tagging hodoscope for ion therapy monitoring

    Science.gov (United States)

    Gallin-Martel, M.-L.; Abbassi, L.; Bes, A.; Bosson, G.; Collot, J.; Crozes, T.; Curtoni, S.; Dauvergne, D.; De Nolf, W.; Fontana, M.; Gallin-Martel, L.; Hostachy, J.-Y.; Krimmer, J.; Lacoste, A.; Marcatili, S.; Morse, J.; Motte, J.-F.; Muraz, J.-F.; Rarbi, F. E.; Rossetto, O.; Salomé, M.; Testa, É.; Vuiart, R.; Yamouni, M.

    2018-01-01

    The MoniDiam project is part of the French national collaboration CLaRyS (Contrôle en Ligne de l'hAdronthérapie par RaYonnements Secondaires) for on-line monitoring of hadron therapy. It relies on the imaging of nuclear reaction products that is related to the ion range. The goal here is to provide large area beam detectors with a high detection efficiency for carbon or proton beams giving time and position measurement at 100 MHz count rates (beam tagging hodoscope). High radiation hardness and intrinsic electronic properties make diamonds reliable and very fast detectors with a good signal to noise ratio. Commercial Chemical Vapor Deposited (CVD) poly-crystalline, heteroepitaxial and monocrystalline diamonds were studied. Their applicability as a particle detector was investigated using α and β radioactive sources, 95 MeV/u carbon ion beams at GANIL and 8.5 keV X-ray photon bunches from ESRF. This facility offers the unique capability of providing a focused ( 1 μm) beam in bunches of 100 ps duration, with an almost uniform energy deposition in the irradiated detector volume, therefore mimicking the interaction of single ions. A signal rise time resolution ranging from 20 to 90 ps rms and an energy resolution of 7 to 9% were measured using diamonds with aluminum disk shaped surface metallization. This enabled us to conclude that polycrystalline CVD diamond detectors are good candidates for our beam tagging hodoscope development. Recently, double-side stripped metallized diamonds were tested using the XBIC (X Rays Beam Induced Current) set-up of the ID21 beamline at ESRF which permits us to evaluate the capability of diamond to be used as position sensitive detector. The final detector will consist in a mosaic arrangement of double-side stripped diamond sensors read out by a dedicated fast-integrated electronics of several hundreds of channels.

  8. X-ray pencil beam facility for optics characterization

    Science.gov (United States)

    Krumrey, Michael; Cibik, Levent; Müller, Peter; Bavdaz, Marcos; Wille, Eric; Ackermann, Marcelo; Collon, Maximilien J.

    2010-07-01

    The Physikalisch-Technische Bundesanstalt (PTB) has used synchrotron radiation for the characterization of optics and detectors for astrophysical X-ray telescopes for more than 20 years. At a dedicated beamline at BESSY II, a monochromatic pencil beam is used by ESA and cosine Research since the end of 2005 for the characterization of novel silicon pore optics, currently under development for the International X-ray Observatory (IXO). At this beamline, a photon energy of 2.8 keV is selected by a Si channel-cut monochromator. Two apertures at distances of 12.2 m and 30.5 m from the dipole source form a pencil beam with a typical diameter of 100 μm and a divergence below 1". The optics to be investigated is placed in a vacuum chamber on a hexapod, the angular positioning is controlled by means of autocollimators to below 1". The reflected beam is registered at 5 m distance from the optics with a CCD-based camera system. This contribution presents design and performance of the upgrade of this beamline to cope with the updated design for IXO. The distance between optics and detector can now be 20 m. For double reflection from an X-ray Optical Unit (XOU) and incidence angles up to 1.4°, this corresponds to a vertical translation of the camera by 2 m. To achieve high reflectance at this angle even with uncoated silicon, a lower photon energy of 1 keV is available from a pair of W/B4C multilayers. For coated optics, a high energy option can provide a pencil beam of 7.6 keV radiation.

  9. Fermilab Test Beam Facility Annual Report FY17

    Energy Technology Data Exchange (ETDEWEB)

    Rominsky, M. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Schmidt, E. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Rivera, R. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Uplegger, L. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Asaadi, J. [Univ. of Texas, Arlington, TX (United States); Raaf, J. L. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Freeman, J. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Price, J. [Univ. of Liverpool (United Kingdom); Casey, B. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Ehrlich, R. [Univ. of Virginia, Charlottesville, VA (United States); Belmont, R. [Univ. of Colorado, Boulder, CO (United States); Boose, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Conners, M. [Georgia State Univ., Atlanta, GA (United States); Haggerty, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Hill, K. [Univ. of Colorado, Boulder, CO (United States); Hodges, A. [Georgia State Univ., Atlanta, GA (United States); Huang, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Kistenev, E. [Brookhaven National Lab. (BNL), Upton, NY (United States); Lajoie, J. [Iowa State Univ., Ames, IA (United States); Mannel, E. [Brookhaven National Lab. (BNL), Upton, NY (United States); Osborn, J. [Univ. of Michigan, Ann Arbor, MI (United States); Pontieri, C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Purschke, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Sarsour, M. [Georgia State Univ., Atlanta, GA (United States); Sen, A. [Iowa State Univ., Ames, IA (United States); Skoby, M. [Univ. of Michigan, Ann Arbor, MI (United States); Stoll, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Toldo, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ujvari, B. [Debrecen Univ., Debrecen (Hungary); Woody, C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ronzhin, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Hanagaki, K. [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Apresyan, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Bose, T. [Boston Univ., MA (United States); Canepa, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Demina, R. [Univ. of Rochester, NY (United States); Gershtein, Y. [Rutgers Univ., Piscataway, NJ (United States); Halkiadakis, E. [Rutgers Univ., Piscataway, NJ (United States); Haytmyradov, M. [Univ. of Iowa, Iowa City, IA (United States); Hazen, E. [Boston Univ., MA (United States); Hindrichs, O. [Univ. of Rochester, NY (United States); Korjenevski, S. [Univ. of Rochester, NY (United States); Nachtman, J. [Univ. of Iowa, Iowa City, IA (United States); Narain, M. [Brown Univ., Providence, RI (United States); Nash, K. [Rutgers Univ., Piscataway, NJ (United States); Onel, Y. [Univ. of Iowa, Iowa City, IA (United States); Osherson, M. [Rutgers Univ., Piscataway, NJ (United States); Rankin, D. [Boston Univ., MA (United States); Schneider, B. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Stone, B. [Rutgers Univ., Piscataway, NJ (United States); Metcalfe, J. [Argonne National Lab. (ANL), Argonne, IL (United States); Benoit, M. [Univ. of Geneva (Switzerland); Vicente, M. [Univ. of Geneva (Switzerland); di Bello, F. [Univ. of Geneva (Switzerland); Cavallaro, E. [Univ. Autonoma de Barcelona (Spain); Chakanov, S. [Argonne National Lab. (ANL), Argonne, IL (United States); Frizzell, D. [Univ. of Oklahoma, Norman, OK (United States); Kiehn, M. [Univ. of Geneva (Switzerland); Meng, L. [Univ. of Geneva (Switzerland); Miucci, A. [Univ. of Bern, Bern (Switzerland); Nodulman, L. [Argonne National Lab. (ANL), Argonne, IL (United States); Terzo, S. [Univ. Autonoma de Barcelona (Spain); Wang, Rui [Argonne National Lab. (ANL), Argonne, IL (United States); Weston, T. [Univ. of Oklahoma, Norman, OK (United States); Xie, Junqie [Argonne National Lab. (ANL), Argonne, IL (United States); Xu, L. [Brookhaven National Lab. (BNL), Upton, NY (United States); Zaffaroni, E. [Univ. of Geneva (Switzerland); Zhang, M. [Univ. of Illinois, Urbana, IL (United States); Argelles, C. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Axani, S. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Conrad, J. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Katori, T. [Queen Mary Univ. of London (United Kingdom); Noulai, M. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Mandalia, S. [Queen Mary Univ. of London (United Kingdom); Sandstrom, P. [Univ. of Wisconsin, Madison, WI (United States); Kryemadhi, A. [Messiah College, Mechanicsburg, PA (United States); Barner, L. [Messiah College, Mechanicsburg, PA (United States); Grove, A. [Messiah College, Mechanicsburg, PA (United States); Mohler, J. [Messiah College, Mechanicsburg, PA (United States); Roth, A. [Messiah College, Mechanicsburg, PA (United States); Beuzekom, M. van [Nikhef National Inst. for Subatomic Physics, Amsterdam (Netherlands); Dall' Occo, E. [Nikhef National Inst. for Subatomic Physics, Amsterdam (Netherlands); Schindler, H. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Paley, J. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Badgett, W. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Denisov, D. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Lukic, S. [Vinca Inst. of Nuclear Sciences, Belgrade (Serbia); Ujic, P. [Vinca Inst. of Nuclear Sciences, Belgrade (Serbia); Lebrun, P. L.G. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Fields, L. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Christian, D. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Zaki, R. [Radboud Univ., Nijmegen (Netherlands)

    2018-01-23

    This Technical Memorandum (TM) summarizes the Fermilab Test Beam operations for FY2017. It is one of a series of annual publications intended to gather information in one place. In this case, the information concerns the individual experiments that ran at FTBF and are listed in Table 1. Each experiment section was prepared by the relevant authors, and was edited for inclusion in this summary.

  10. Pitfalls of tungsten multileaf collimator in proton beam therapy

    International Nuclear Information System (INIS)

    Moskvin, Vadim; Cheng, Chee-Wai; Das, Indra J.

    2011-01-01

    Purpose: Particle beam therapy is associated with significant startup and operational cost. Multileaf collimator (MLC) provides an attractive option to improve the efficiency and reduce the treatment cost. A direct transfer of the MLC technology from external beam radiation therapy is intuitively straightforward to proton therapy. However, activation, neutron production, and the associated secondary cancer risk in proton beam should be an important consideration which is evaluated. Methods: Monte Carlo simulation with FLUKA particle transport code was applied in this study for a number of treatment models. The authors have performed a detailed study of the neutron generation, ambient dose equivalent [H*(10)], and activation of a typical tungsten MLC and compared with those obtained from a brass aperture used in a typical proton therapy system. Brass aperture and tungsten MLC were modeled by absorber blocks in this study, representing worst-case scenario of a fully closed collimator. Results: With a tungsten MLC, the secondary neutron dose to the patient is at least 1.5 times higher than that from a brass aperture. The H*(10) from a tungsten MLC at 10 cm downstream is about 22.3 mSv/Gy delivered to water phantom by noncollimated 200 MeV beam of 20 cm diameter compared to 14 mSv/Gy for the brass aperture. For a 30-fraction treatment course, the activity per unit volume in brass aperture reaches 5.3 x 10 4 Bq cm -3 at the end of the last treatment. The activity in brass decreases by a factor of 380 after 24 h, additional 6.2 times after 40 days of cooling, and is reduced to background level after 1 yr. Initial activity in tungsten after 30 days of treating 30 patients per day is about 3.4 times higher than in brass that decreases only by a factor of 2 after 40 days and accumulates to 1.2 x 10 6 Bq cm -3 after a full year of operation. The daily utilization of the MLC leads to buildup of activity with time. The overall activity continues to increase due to 179 Ta with

  11. The fiber-SiPMT beam monitor of the R484 experiment at the RIKEN-RAL muon facility

    International Nuclear Information System (INIS)

    Carbone, R.; Vacchi, A.; Vallazza, E.; Zampa, G.; Bonesini, M.; Bertoni, R.; Mazza, R.; Rossella, M.; Tortora, L.

    2015-01-01

    The scintillating fibers SiPM based beam monitor detector, designed to deliver position, shape and timing of the low energy muon beam at the RIKEN-RAL muon facility for the R484 experiment, has been successfully tested on the electron beam at the Beam Test Facility (BTF) of the INFN LNF laboratories. We report here the lay out and the read out structure as well as the very promising results

  12. Thermal neutron beam modification studies using an isotope based neutron radiography facility

    International Nuclear Information System (INIS)

    Baheti, G.L.; Khatri, P.K.; Meghwal, L.R.; Meena, V.L.

    1996-01-01

    Neutron radiography has established itself as one of the advanced NDT technique. Isotope based facilities are being developed to make the technique available for inplant use. Quality of neutron radiograph obtained is a function of beam parameters like flux, Cd ratio and neutron to gamma ratio, scattered neutrons etc. These parameters can be modified using design features of the facility. Effect of modifications in these parameters on final image quality has been studied and were found to be useful in meeting the widely varying radiographic requirements, particularly through an isotope based facility. These modifications can also overcome some of the inherent limitations of isotope based neutron radiography facilities. (author)

  13. Physics and Technology for the Next Generation of Radioactive Ion Beam Facilities: EURISOL

    CERN Document Server

    Kadi, Y; Catherall, R; Giles, T; Stora, T; Wenander, F K

    2012-01-01

    Since the discovery of artificial radioactivity in 1935, nuclear scientists have developed tools to study nuclei far from stability. A major breakthrough came in the eighties when the first high energy radioactive beams were produced at Berkeley, leading to the discovery of neutron halos. The field of nuclear structure received a new impetus, and the major accelerator facilities worldwide rivalled in ingenuity to produce more intense, purer and higher resolution rare isotope beams, leading to our much improved knowledge and understanding of the general evolution of nuclear properties throughout the nuclear chart. However, today, further progress is hampered by the weak beam intensities of current installations which correlate with the difficulty to reach the confines of nuclear binding where new phenomena are predicted, and where the r-process path for nuclear synthesis is expected to be located. The advancement of Radioactive Ion Beam (RIB) science calls for the development of so-called next-generation facil...

  14. A Micromegas Detector for Neutron Beam Imaging at the n_TOF Facility at CERN

    CERN Document Server

    Belloni, F; Berthoumieux, E; Calviani, M; Chiaveri, E; Colonna, N; Giomataris, Y; Guerrero, C; Gunsing, F; Iguaz, F J; Kebbiri, M; Pancin, J; Papaevangelou, T; Tsinganis, A; Vlachoudis, V; Altstadt, S; Andrzejewski, J; Audouin, L; Barbagallo, M; Bécares, V; Bečvář, F; Billowes, J; Boccone, V; Bosnar, D; Brugger, M; Calviño, F; Cano-Ott, D; Carrapiço, C; Cerutti, F; Chiaveri, E; Chin, M; Cortés, G; Corté-Giraldo, M A; Diakaki, M; Domingo-Pardo, C; Duran, I; Dzysiuk, N; Eleftheriadis, C; Ferrari, A; Fraval, K; Ganesan, S; García, A R; Giubrone, G; Gómez-Hornillos, M B; Gonçalves, I F; González-Romero, E; Griesmayer, E; Gurusamy, P; Jenkins, D G; Jericha, E; Kadi, Y; Käppeler, F; Karadimos, D; Koehler, P; Kokkoris, M; Krtička, M; Kroll, J; Langer, C; Lederer, C; Leeb, H; Leong, L S; Losito, R; Manousos, A; Marganiec, J; Marítnez, T; Massimi, C; Mastinu, P F; Mastromarco, M; Meaze, M; Mendoza, E; Mengoni, A; Milazzo, P M; Mingrone, F; Mirea, M; Mondalaers, W; Paradela, C; Pavlik, A; Perkowski, J; Plompen, A J M; Praena, J; Quesada, J M; Rauscher, T; Reifarth, R; Riego, A; Roman, F; Rubbia, C; Sarmento, R; Schillebeeckx, P; Schmidt, S; Tagliente, G; Tain, J L; Tarrío, D; Tassan-Got, L; Valenta, S; Vannini, G; Variale, V; Vaz, P; Ventura, A; Versaci, R; Vermeulen, M J; Vlastou, R; Wallner, A; Ware, T; Weigand, M; Weiss, C; Wright, T J; Žugec, P

    2014-01-01

    Micromegas (Micro-MEsh Gaseous Structure) detectors are gas detectors consisting of a stack of one ionization and one proportional chamber. A micromesh separates the two communicating regions, where two different electric fields establish respectively a charge drift and a charge multiplication regime. The n\\_TOF facility at CERN provides a white neutron beam (from thermal up to GeV neutrons) for neutron induced cross section measurements. These measurements need a perfect knowlodge of the incident neutron beam, in particular regarding its spatial profile. A position sensitive micromegas detector equipped with a B-10 based neutron/charged particle converter has been extensively used at the n\\_TOF facility for characterizing the neutron beam profile and extracting the beam interception factor for samples of different size. The boron converter allowed to scan the energy region of interest for neutron induced capture reactions as a function of the neutron energy, determined by the time of flight. Experimental ...

  15. Dosimetry auditing procedure with alanine dosimeters for light ion beam therapy.

    Science.gov (United States)

    Ableitinger, Alexander; Vatnitsky, Stanislav; Herrmann, Rochus; Bassler, Niels; Palmans, Hugo; Sharpe, Peter; Ecker, Swantje; Chaudhri, Naved; Jäkel, Oliver; Georg, Dietmar

    2013-07-01

    In the next few years the number of facilities providing ion beam therapy with scanning beams will increase. An auditing process based on an end-to-end test (including CT imaging, planning and dose delivery) could help new ion therapy centres to validate their entire logistic chain of radiation delivery. An end-to-end procedure was designed and tested in both scanned proton and carbon ion beams, which may also serve as a dosimetric credentialing procedure for clinical trials in the future. The developed procedure is focused only on physical dose delivery and the validation of the biological dose is out of scope of the current work. The audit procedure was based on a homogeneous phantom that mimics the dimension of a head (20 × 20 × 21 cm(3)). The phantom can be loaded either with an ionisation chamber or 20 alanine dosimeters plus 2 radiochromic EBT films. Dose verification aimed at measuring a dose of 10Gy homogeneously delivered to a virtual-target volume of 8 × 8 × 12 cm(3). In order to interpret the readout of the irradiated alanine dosimeters additional Monte Carlo simulations were performed to calculate the energy dependent detector response of the particle fluence in the alanine detector. A pilot run was performed with protons and carbon ions at the Heidelberg Ion Therapy facility (HIT). The mean difference of the absolute physical dose measured with the alanine dosimeters compared with the expected dose from the treatment planning system was -2.4 ± 0.9% (1σ) for protons and -2.2 ± 1.1% (1σ) for carbon ions. The measurements performed with the ionisation chamber indicate this slight underdosage with a dose difference of -1.7% for protons and -1.0% for carbon ions. The profiles measured by radiochromic films showed an acceptable homogeneity of about 3%. Alanine dosimeters are suitable detectors for dosimetry audits in ion beam therapy and the presented end-to-end test is feasible. If further studies show similar results, this dosimetric audit could be

  16. Optimization study for an epithermal neutron beam for boron neutron capture therapy at the University of Virginia Research Reactor

    International Nuclear Information System (INIS)

    Burns, T.D. Jr.

    1995-05-01

    The non-surgical brain cancer treatment modality, Boron Neutron Capture Therapy (BNCT), requires the use of an epithermal neutron beam. This purpose of this thesis was to design an epithermal neutron beam at the University of Virginia Research Reactor (UVAR) suitable for BNCT applications. A suitable epithermal neutron beam for BNCT must have minimal fast neutron and gamma radiation contamination, and yet retain an appreciable intensity. The low power of the UVAR core makes reaching a balance between beam quality and intensity a very challenging design endeavor. The MCNP monte carlo neutron transport code was used to develop an equivalent core radiation source, and to perform the subsequent neutron transport calculations necessary for beam model analysis and development. The code accuracy was validated by benchmarking output against experimental criticality measurements. An epithermal beam was designed for the UVAR, with performance characteristics comparable to beams at facilities with cores of higher power. The epithermal neutron intensity of this beam is 2.2 x 10 8 n/cm 2 · s. The fast neutron and gamma radiation KERMA factors are 10 x 10 -11 cGy·cm 2 /n epi and 20 x 10 -11 cGy·cm 2 /n epi , respectively, and the current-to-flux ratio is 0.85. This thesis has shown that the UVAR has the capability to provide BNCT treatments, however the performance characteristics of the final beam of this study were limited by the low core power

  17. A large acceptance spectrometer for reaccelerated radioactive beams at the proposed facility for rare isotope beams (FRIB) in the USA

    International Nuclear Information System (INIS)

    Souliotis, G.A.

    2008-01-01

    A large acceptance ray-tracing spectrometer is being designed in order to fully exploit the research opportunities that will be offered by reaccelerated radioactive beams in the energy range 6-15 MeV/nucleon from the proposed facility for rare isotope beams (FRIB) in the USA. The preliminary design of the spectrometer has been benefitted by several similar instruments in Europe (e.g. VAMOS, PRISMA, MAGNEX). The design is of QQD type (quadrupole-quadrupole-dipole) with two large-bore quadrupoles and a large-gap 70 o bending magnet offering an angular acceptance around 50 msr and a momentum acceptance of 10%. The maximum magnetic rigidity is 2.5 T-m, providing a range appropriate for the most neutron-rich products expected from binary reactions with reaccelerated radioactive beams. The spectrometer will play an important role in nuclear structure and reaction studies, combined with gamma-ray and particle detector arrays around the target.

  18. Fast pencil beam dose calculation for proton therapy using a double-Gaussian beam model

    Directory of Open Access Journals (Sweden)

    Joakim eda Silva

    2015-12-01

    Full Text Available The highly conformal dose distributions produced by scanned proton pencil beams are more sensitive to motion and anatomical changes than those produced by conventional radiotherapy. The ability to calculate the dose in real time as it is being delivered would enable, for example, online dose monitoring, and is therefore highly desirable. We have previously described an implementation of a pencil beam algorithm running on graphics processing units (GPUs intended specifically for online dose calculation. Here we present an extension to the dose calculation engine employing a double-Gaussian beam model to better account for the low-dose halo. To the best of our knowledge, it is the first such pencil beam algorithm for proton therapy running on a GPU. We employ two different parametrizations for the halo dose, one describing the distribution of secondary particles from nuclear interactions found in the literature and one relying on directly fitting the model to Monte Carlo simulations of pencil beams in water. Despite the large width of the halo contribution, we show how in either case the second Gaussian can be included whilst prolonging the calculation of the investigated plans by no more than 16%, or the calculation of the most time-consuming energy layers by about 25%. Further, the calculation time is relatively unaffected by the parametrization used, which suggests that these results should hold also for different systems. Finally, since the implementation is based on an algorithm employed by a commercial treatment planning system, it is expected that with adequate tuning, it should be able to reproduce the halo dose from a general beam line with sufficient accuracy.

  19. Design study of beam transport lines for BioLEIR facility at CERN

    Science.gov (United States)

    Ghithan, S.; Roy, G.; Schuh, S.

    2017-09-01

    The biomedical community has asked CERN to investigate the possibility to transform the Low Energy Ion Ring (LEIR) accelerator into a multidisciplinary, biomedical research facility (BioLEIR) that could provide ample, high-quality beams of a range of light ions suitable for clinically oriented, fundamental research on cell cultures and for radiation instrumentation development. The present LEIR machine uses fast beam extraction to the next accelerator in the chain, eventually leading to the Large Hadron Collider (LHC) . To provide beam for a biomedical research facility, a new slow extraction system must be installed. Two horizontal and one vertical experimental beamlines were designed for transporting the extracted beam to three experimental end-stations. The vertical beamline (pencil beam) was designed for a maximum energy of 75 MeV/u for low-energy radiobiological research, while the two horizontal beamlines could deliver up to 440 MeV/u. One horizontal beamline shall be used preferentially for biomedical experiments and shall provide pencil beam and a homogeneous broad beam, covering an area of 5 × 5 cm2 with a beam homogeneity of ±5%. The second horizontal beamline will have pencil beam only and is intended for hardware developments in the fields of (micro-)dosimetry and detector development. The minimum full aperture of the beamlines is approximately 100 mm at all magnetic elements, to accommodate the expected beam envelopes. Seven dipoles and twenty quadrupoles are needed for a total of 65 m of beamlines to provide the specified beams. In this paper we present the optical design for the three beamlines.

  20. Automatic beam position control at Los Alamos Spallation Radiation Effects Facility (LASREF)

    International Nuclear Information System (INIS)

    Oothoudt, M.; Pillai, C.; Zumbro, M.

    1997-01-01

    Historically the Los Alamos Spallation Radiation Effects Facility (LASREF) has used manual methods to control the position of the 800 kW, 800 MeV proton beam on targets. New experiments, however, require more stringent position control more frequently than can be done manually for long periods of time. Data from an existing harp is used to automatically adjust steering magnets to maintain beam position to required tolerances

  1. Electron beam irradiation facility for low to high dose irradiation applications

    International Nuclear Information System (INIS)

    Petwal, V.C.; Wanmode, Yashwant; Verma, Vijay Pal; Bhisikar, Abhay; Dwivedi, Jishnu; Shrivastava, P.; Gupta, P.D.

    2013-01-01

    Electron beam based irradiation facilities are becoming more and more popular over the conventional irradiator facilities due to many inherent advantages such as tunability of beam energy, availability of radiation both in electron mode and X-ray mode, wide range of the dose rate, control of radiation from a ON-OFF switch and other safety related merits. A prototype experimental facility based on electron accelerator has been set-up at RRCAT to meet the low-dose, medium dose and high-dose requirements for radiation processing of food, agricultural and medical products. The facility can be operated in the energy range from 7-10 MeV at variable power level from 0.05-3 kW to meet the dose rate requirement of 100 Gy to kGy. The facility is also equipped with a Bremsstrahlung converter optimized for X-ray irradiation at 7.5 MV. Availability of dose delivery in wide range with precision control and measurement has made the facility an excellent tool for researchers interested in electron/X-ray beam irradiation. A precision dosimetry lab based on alanine EPR and radiochromic film dosimetry system have been established to characterize the radiation field and precise dose measurements. Electron beam scattering technique has been developed to achieve low dose requirement for EB irradiation of various seeds such as groundnut, wheat, soybeans, moong beans, black gram etc. for mutation related studies. This paper describes various features of the facility together with the dosimetric measurements carried out for qualification of the facility and recent irradiation experiments carried out using this facility. (author)

  2. OPTIMIZATION OF THE EPITHERMAL NEUTRON BEAM FOR BORON NEUTRON CAPTURE THERAPY AT THE BROOKHAVEN MEDICAL RESEARCH REACTOR.

    Energy Technology Data Exchange (ETDEWEB)

    HU,J.P.; RORER,D.C.; RECINIELLO,R.N.; HOLDEN,N.E.

    2002-08-18

    Clinical trials of Boron Neutron Capture Therapy for patients with malignant brain tumor had been carried out for half a decade, using an epithermal neutron beam at the Brookhaven's Medical Reactor. The decision to permanently close this reactor in 2000 cut short the efforts to implement a new conceptual design to optimize this beam in preparation for use with possible new protocols. Details of the conceptual design to produce a higher intensity, more forward-directed neutron beam with less contamination from gamma rays, fast and thermal neutrons are presented here for their potential applicability to other reactor facilities. Monte Carlo calculations were used to predict the flux and absorbed dose produced by the proposed design. The results were benchmarked by the dose rate and flux measurements taken at the facility then in use.

  3. Characterization of Dosimetry of the BMRR Horizontal Thimble Tubes and Broad Beam Facility.

    Energy Technology Data Exchange (ETDEWEB)

    Hu,J.P.; Reciniello, R.N.; Holden, N.E.

    2008-05-05

    The Brookhaven Medical Research Reactor was a 5 mega-watt, light-water cooled and heavy-graphite moderated research facility. It has two shutter-equipped treatment rooms, three horizontally extended thimble tubes, and an ex-core broad beam facility. The three experimental thimbles, or activation ports, external to the reactor tank were designed for several uses, including the investigations on diagnostic and therapeutic methods using radioactive isotopes of very short half-life, the analysis of radiation exposure on tissue-equivalent materials using a collimated neutron beam, and the evaluation of dose effects on biological cells to improve medical treatment. At the broad beam facility where the distribution of thermal neutrons was essential uniform, a wide variety of mammalian whole-body exposures were studied using animals such as burros or mice. Also studied at the broad beam were whole-body phantom experiments, involving the use of a neutron or photon beam streaming through a screen to obtain the flux spectrum suitable for dose analysis on the sugar-urea-water mixture, a tissue-equivalent material. Calculations of the flux and the dose at beam ports based on Monte Carlo particle-transport code were performed, and measurements conducted at the same tally locations were made using bare or cadmium-covered gold foils. Analytical results, which show good agreement with measurement data, are presented in the paper.

  4. Target irradiation facility and targetry development at 160 MeV proton beam of Moscow linac

    CERN Document Server

    Zhuikov, B L; Konyakhin, N A; Vincent, J

    1999-01-01

    A facility has been built and successfully operated with the 160 MeV proton beam of Moscow Meson factory LINAC, Institute for Nuclear Research (INR) of Russian Academy of Science, Troitsk. The facility was created for various isotope production goals as well as for fundamental nuclear investigations at high intensity beam (100 mu A and more). An important part of the facility targetry system is a high-intensity beam monitoring collimator device. Measurements of the temperature distribution between collimator sectors, cooling water flow and temperature, and the beam current, provide an opportunity to compute beam losses and beam position. The target holder design allows easy insertion by manipulator and simultaneous bombardment of several different targets of various types and forms, and variation of proton energy on each target over a wide range below 160 MeV. The main target utilized for commercial sup 8 sup 2 Sr isotope production is metallic rubidium in a stainless-steel container. A regular wet chemistry ...

  5. Initial electron-beam characterizations for the Los Alamos APEX Facility

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, A.H.; Feldman, R.B.; Apgar, S.A.; Feldman, D.W.; O' Shea, P.G. (Los Alamos National Lab., NM (United States)); Fiorito, R.B.; Rule, D.W. (Naval Surface Warfare Center, Silver Spring, MD (United States))

    1991-01-01

    The ongoing upgrade of the Los Alamos Free-Electron Laser (FEL) Facility involves the addition of a photoelectric injector (PEI) and acceleration capability to about 40 MeV. The electron-beam and high-speed diagnostics provide key measurements of charge, beam position and profile, divergence emittance, energy (centroid, spread, slew, and extraction efficiency), micropulse duration, and phase stability. Preliminary results on the facility include optical transition radiation interferometer measurements of divergence (1 to 2 mrad), FEL extraction efficiency (0.6 {plus minus} 0.2%), and drive laser phase stability (< 2 ps (rms)). 10 refs.

  6. Initial electron-beam characterizations for the Los Alamos APEX Facility

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, A.H.; Feldman, R.B.; Apgar, S.A.; Feldman, D.W.; O`Shea, P.G. [Los Alamos National Lab., NM (United States); Fiorito, R.B.; Rule, D.W. [Naval Surface Warfare Center, Silver Spring, MD (United States)

    1991-12-31

    The ongoing upgrade of the Los Alamos Free-Electron Laser (FEL) Facility involves the addition of a photoelectric injector (PEI) and acceleration capability to about 40 MeV. The electron-beam and high-speed diagnostics provide key measurements of charge, beam position and profile, divergence emittance, energy (centroid, spread, slew, and extraction efficiency), micropulse duration, and phase stability. Preliminary results on the facility include optical transition radiation interferometer measurements of divergence (1 to 2 mrad), FEL extraction efficiency (0.6 {plus_minus} 0.2%), and drive laser phase stability (< 2 ps [rms]). 10 refs.

  7. Generation of negative slow muon beam in J-PARC muon facility

    International Nuclear Information System (INIS)

    Kawamura, Naritoshi; Masuda, Tetsuya; Strasser, Patrick; Miyake, Yasuhiro

    2010-01-01

    The world strongest pulsed muon facility has been operated since 2008 in J-PARC (Japan Proton Accelerator Research Complex). This facility utilizes 3-GeV proton to produce muon beam, and thus the negative pion and also negative muon yields are superior to the other meson factories in the world. We try to slow down these negative muons. Negative slow muon beam is desired to check the standard model and search a new physical rule, as well as various applications in material science.

  8. Measuring Dirac CP-violating phase with intermediate energy beta beam facility

    Science.gov (United States)

    Bakhti, P.; Farzan, Y.

    2014-02-01

    Taking the established nonzero value of , we study the possibility of extracting the Dirac CP-violating phase by a beta beam facility with a boost factor . We compare the performance of different setups with different baselines, boost factors, and detector technologies. We find that an antineutrino beam from He decay with a baseline of km has a very promising CP-discovery potential using a 500 kton water Cherenkov detector. Fortunately this baseline corresponds to the distance between FermiLAB to Sanford underground research facility in South Dakota.

  9. Status of the Medaustron Ion Beam Therapy centre

    CERN Document Server

    Dorda, U; Osmic, F; Benedikt, M

    2012-01-01

    MedAustron is a synchrotron based light-ion beam therapy centre for cancer treatment as well as for clinical and non-clinical research currently in its construction phase. The accelerator design is based on the CERN-PIMMS study and its technical implementation by CNAO. This paper presents a status overview over the whole project detailing the achieved progress of the building construction & technical infrastructure installation in Wiener Neustadt, Austria, as well as of the accelerator development, performed at CERN and partially at PSI. The design and procurement status and future planning of the various accelerator components is elaborated.

  10. Alanine EPR dosimeter response in proton therapy beams

    International Nuclear Information System (INIS)

    Gall, K.; Serago, C.; Desrosiers, M.; Bensen, D.

    1997-01-01

    We report a series of measurements directed to assess the suitability of alanine as a mailable dosimeter for dosimetry quality assurance of proton radiation therapy beams. These measurements include dose-response of alanine at 140 MeV, and comparison of response vs energy with a parallel plate ionization chamber. All irradiations were made at the Harvard Cyclotron Laboratory, and the dosimeters were read at NIST. The results encourage us that alanine could be expected to serve as a mailable dosimeter with systematic error due to differential energy response no greater than 3% when doses of 25 Gy are used. (Author)

  11. Improvements for extending the time between maintenance periods for the Heidelberg ion beam therapy center (HIT) ion sources.

    Science.gov (United States)

    Winkelmann, Tim; Cee, Rainer; Haberer, Thomas; Naas, Bernd; Peters, Andreas; Schreiner, Jochen

    2014-02-01

    The clinical operation at the Heidelberg Ion Beam Therapy Center (HIT) started in November 2009; since then more than 1600 patients have been treated. In a 24/7 operation scheme two 14.5 GHz electron cyclotron resonance ion sources are routinely used to produce protons and carbon ions. The modification of the low energy beam transport line and the integration of a third ion source into the therapy facility will be shown. In the last year we implemented a new extraction system at all three sources to enhance the lifetime of extraction parts and reduce preventive and corrective maintenance. The new four-electrode-design provides electron suppression as well as lower beam emittance. Unwanted beam sputtering effects which typically lead to contamination of the insulator ceramics and subsequent high-voltage break-downs are minimized by the beam guidance of the new extraction system. By this measure the service interval can be increased significantly. As a side effect, the beam emittance can be reduced allowing a less challenging working point for the ion sources without reducing the effective beam performance. This paper gives also an outlook to further enhancements at the HIT ion source testbench.

  12. External beam radiotherapy facilities in Ukraine. Trends and challenges

    International Nuclear Information System (INIS)

    Starenkiy, V.P.; Petrichenko, O.O.; Averyanova, L.O.

    2017-01-01

    The most important aspects of technological support of the radiation therapy of Ukraine are considered in accordance with the requirements of the IAEA. The reasons that influence the availability of radiotherapy for cancer patients in Ukraine are analyzed taking into account the experience of Grigoriev Institute for Medical Radiology of the National Academy of Medical Sciences of Ukraine.

  13. Monte Carlo Simulations of New 2D Ripple Filters for Particle Therapy Facilities

    DEFF Research Database (Denmark)

    Ringbæk, Toke Printz; Weber, Uli; Petersen, Jørgen B.B.

    2014-01-01

    Introduction: At particle therapy facilities with pencil beam scanning, the implementation of a Ripple Filter (RiFi) broadens the Bragg peak (BP), which leads to fewer energy steps from the accelerator required to obtain a homogeneous dose coverage of the planned target volume (PTV...... for various ion types, initial particle energies and distances from the RiFi to the phantom surface as well as in the depth of the phantom. The beam delivery and monitor system (BAMS) used at Marburg, the Heidelberg Ionentherapiezentrum (HIT), Universit ̈tsklinikum Heidelberg, Germany and the GSI...... needed by TRiP, and for recalculating the physical dose distribution after TRiP optimization. Results: At short distances from the RiFi to the phantom surface fine structures in the dose distribution are observed. For various RiFis, ion types and initial particle energies the distance dmax at which...

  14. Developing an expert system to control a beam line at the Los Alamos Meson Physics Facility

    International Nuclear Information System (INIS)

    Clearwater, S.H.; Papcun, G.; Clark, D.A.

    1985-01-01

    High energy particle experiments require an accelerator as a source of high energy particles. To increase the productivity of an accelerator facility, we wish to develop an expert system to control beam lines. Expert Systems are a branch of Artificial Intelligence where a computer program performs tasks requiring human expertise. Unlike most expert systems we have a physical model underlying our beam line and this model can be used with the expert system to improve performance. The development of the expert system will lead to an increased understanding of the beam line as well as the possibility of state-of-the-art expert system building

  15. Facile electron-beam lithography technique for irregular and fragile substrates

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Jiyoung; Zhou, Qin; Zettl, Alex, E-mail: azettl@berkeley.edu [Department of Physics, University of California at Berkeley, Berkeley, California 94720 (United States); Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Kavli Energy NanoSciences Institute at the University of California, Berkeley, California 94720 (United States)

    2014-10-27

    A facile technique is presented which enables high-resolution electron beam lithography on irregularly-shaped, non-planar or fragile substrates such as the edges of a silicon chip, thin and narrow suspended beams and bridges, or small cylindrical wires. The method involves a spin-free dry-transfer of pre-formed uniform-thickness polymethyl methacrylate, followed by conventional electron beam writing, metal deposition, and lift-off. High-resolution patterning is demonstrated for challenging target substrates. The technique should find broad application in micro- and nano-technology research arenas.

  16. Proton-beam window design for a transmutation facility operating with a liquid lead target

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, C.; Lypsch, F.; Lizana, P. [Institute for Safety Research and Reactor Technology, Juelich (Germany)] [and others

    1995-10-01

    The proton beam target of an accelerator-driven transmutation facility can be designed as a vertical liquid lead column. To prevent lead vapor from entering the accelerator vacuum, a proton-beam window has to separate the area above the lead surface from the accelerator tube. Two radiation-cooled design alternatives have been investigated which should withstand a proton beam of 1.6 GeV and 25 mA. Temperature calculations based on energy deposition calculations with the Monte Carlo code HETC, stability analysis and spallation-induced damage calculations have been performed showing the applicability of both designs.

  17. The JANNUS Saclay facility: A new platform for materials irradiation, implantation and ion beam analysis

    Energy Technology Data Exchange (ETDEWEB)

    Pellegrino, S., E-mail: stephanie.pellegrino@cea.fr [CEA, INSTN, UEPTN, Laboratoire JANNUS, F-91191 Gif-sur-Yvette (France); Trocellier, P.; Miro, S.; Serruys, Y.; Bordas, E.; Martin, H. [CEA, DEN, Service de Recherches de Metallurgie Physique, Laboratoire JANNUS, F-91191 Gif-sur-Yvette (France); Chaabane, N.; Vaubaillon, S. [CEA, INSTN, UEPTN, Laboratoire JANNUS, F-91191 Gif-sur-Yvette (France); Gallien, J.P.; Beck, L. [CEA, DEN, Service de Recherches de Metallurgie Physique, Laboratoire JANNUS, F-91191 Gif-sur-Yvette (France)

    2012-02-15

    The third accelerator of the multi-ion irradiation platform JANNUS (Joint Accelerators for Nanosciences and NUclear Simulation), a 6SDH-2 Pelletron from National Electrostatic Corporation, Middleton was installed at Saclay in October 2009. The first triple beam irradiation combining Fe, He and H ion beams has been performed in March 2010. In the first part of this paper, we give a technical description of the triple beam facility, its performances and experimental capabilities. Typically, damage dose up to 100 dpa can be reached in 10 h irradiation with heavy ion beams, with or without simultaneous bombardment by protons, helium-4 ions or any other heavy ion beam. In the second part of this paper, we illustrate some IBA results obtained after irradiation and implantation experiments.

  18. The JANNUS Saclay facility: A new platform for materials irradiation, implantation and ion beam analysis

    Science.gov (United States)

    Pellegrino, S.; Trocellier, P.; Miro, S.; Serruys, Y.; Bordas, É.; Martin, H.; Chaâbane, N.; Vaubaillon, S.; Gallien, J. P.; Beck, L.

    2012-02-01

    The third accelerator of the multi-ion irradiation platform JANNUS (Joint Accelerators for Nanosciences and NUclear Simulation), a 6SDH-2 Pelletron from National Electrostatic Corporation, Middleton was installed at Saclay in October 2009. The first triple beam irradiation combining Fe, He and H ion beams has been performed in March 2010. In the first part of this paper, we give a technical description of the triple beam facility, its performances and experimental capabilities. Typically, damage dose up to 100 dpa can be reached in 10 h irradiation with heavy ion beams, with or without simultaneous bombardment by protons, helium-4 ions or any other heavy ion beam. In the second part of this paper, we illustrate some IBA results obtained after irradiation and implantation experiments.

  19. Concepts for the magnetic design of the MITICA neutral beam test facility ion accelerator.

    Science.gov (United States)

    Chitarin, G; Agostinetti, P; Marconato, N; Marcuzzi, D; Sartori, E; Serianni, G; Sonato, P

    2012-02-01

    The megavolt ITER injector concept advancement neutral injector test facility will be constituted by a RF-driven negative ion source and by an electrostatic Accelerator, designed to produce a negative Ion with a specific energy up to 1 MeV. The beam is then neutralized in order to obtain a focused 17 MW neutral beam. The magnetic configuration inside the accelerator is of crucial importance for the achievement of a good beam efficiency, with the early deflection of the co-extracted and stripped electrons, and also of the required beam optic quality, with the correction of undesired ion beamlet deflections. Several alternative magnetic design concepts have been considered, comparing in detail the magnetic and beam optics simulation results, evidencing the advantages and drawbacks of each solution both from the physics and engineering point of view.

  20. A new ion beam facility based on a 3 MV Tandetron™ at IFIN-HH, Romania

    Energy Technology Data Exchange (ETDEWEB)

    Burducea, I.; Straticiuc, M. [Horia Hulubei National Institute of Physics and Nuclear Engineering, IFIN-HH, Măgurele 077125 (Romania); Ghiță, D.G., E-mail: dan.ghita@nipne.ro [Horia Hulubei National Institute of Physics and Nuclear Engineering, IFIN-HH, Măgurele 077125 (Romania); Moșu, D.V.; Călinescu, C.I. [Horia Hulubei National Institute of Physics and Nuclear Engineering, IFIN-HH, Măgurele 077125 (Romania); Podaru, N.C.; Mous, D.J.W. [High Voltage Engineering Europa B.V., P.O. Box 99, 3800AB Amersfoort (Netherlands); Ursu, I.; Zamfir, N.V. [Horia Hulubei National Institute of Physics and Nuclear Engineering, IFIN-HH, Măgurele 077125 (Romania)

    2015-09-15

    A 3 MV Tandetron™ accelerator system has been installed and commissioned at the “Horia Hulubei” National Institute for Physics and Nuclear Engineering – IFIN-HH, Măgurele, Romania. The main purpose of this machine is to strengthen applied nuclear physics research ongoing in our institute for more than four decades. The accelerator system was developed by High Voltage Engineering Europa B.V. (HVE) and comprises three high energy beam lines. The first beam line is dedicated to ion beam analysis (IBA) techniques: Rutherford Backscattering Spectrometry – RBS, Nuclear Reaction Analysis – NRA, Particle Induced X-ray and γ-ray Emission – PIXE and PIGE and micro-beam experiments – μ-PIXE. The second beam line is dedicated to high energy ion implantation experiments and the third beam line was designed mainly for nuclear cross-sections measurements used in nuclear astrophysics. A unique feature, the first time in operation at an accelerator facility is the Na charge exchange canal (CEC), which is used to obtain high intensity beams of He{sup −} of at least 3 μA. The results of the acceptance tests demonstrate the huge potential of this new facility in various fields, from IBA to radiation hardness studies and from medical or environmental applications to astrophysics. The main features of the accelerator are presented in this paper.

  1. Expanding options in radiation oncology: neutron beam therapy

    International Nuclear Information System (INIS)

    Cohen, L.

    1982-01-01

    Twelve years experience with neutron beam therapy in Britain, the USA, Europe and Japan shows that local control is achievable in late-stage epidermoid cancer somewhat more frequently than with conventional radiotherapy. Tumours reputed to be radioresistant (salivary gland, bladder, rectosigmoid, melanoma, bone and soft-tissue sarcomas) have proved to be particularly responsive to neutrons. Pilot studies in brain and pancreatic tumours suggest promising new approaches to management of cancer in these sites. The availability of neutron therapy in the clinical environment opens new prospects for irradiation of 'radioresistant' tumours, permits more conservative cancer surgery, expands the use of elective chemotherapy and provides a wider range of options for cancer patients. (author)

  2. Improving Outcomes for Esophageal Cancer using Proton Beam Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Chuong, Michael D. [Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, Maryland (United States); Hallemeier, Christopher L. [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Jabbour, Salma K. [Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey (United States); Yu, Jen; Badiyan, Shahed [Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, Maryland (United States); Merrell, Kenneth W. [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Mishra, Mark V. [Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, Maryland (United States); Li, Heng [Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Verma, Vivek [Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska (United States); Lin, Steven H., E-mail: shlin@mdanderson.org [Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)

    2016-05-01

    Radiation therapy (RT) plays an essential role in the management of esophageal cancer. Because the esophagus is a centrally located thoracic structure there is a need to balance the delivery of appropriately high dose to the target while minimizing dose to nearby critical structures. Radiation dose received by these critical structures, especially the heart and lungs, may lead to clinically significant toxicities, including pneumonitis, pericarditis, and myocardial infarction. Although technological advancements in photon RT delivery like intensity modulated RT have decreased the risk of such toxicities, a growing body of evidence indicates that further risk reductions are achieved with proton beam therapy (PBT). Herein we review the published dosimetric and clinical PBT literature for esophageal cancer, including motion management considerations, the potential for reirradiation, radiation dose escalation, and ongoing esophageal PBT clinical trials. We also consider the potential cost-effectiveness of PBT relative to photon RT.

  3. Two years of operating experience with the Seattle clinical neutron therapy facility

    International Nuclear Information System (INIS)

    Risler, R.; Brossard, S.; Eenmaa, J.; Kalet, I.; Wootton, P.

    1987-01-01

    After five years of planning, equipment acquisition, facility construction and beam testing the Seattle Clinical Neutron Therapy facility became operational in October 1984. In the past two years nearly 300 people have been treated in clinical trials. During this time 82 % of the planned treatment sessions were performed on schedule, 3 % had to be rescheduled for patient related reasons and 15 % because of equipment problems. The facility is at present running on a 5 days/week schedule: Three ten-hour treatment days, one maintenance day and one research day (radiobiology, therapy related physics). Short runs for short lived isotopes are done between patient treatments. The isocentric gantry, capable of 360 rotation is equipped with a variable collimator with 40 independent leaves. This collimation system allows the use of complex field shapes without the necessity of handling radioactive components like collimator inserts or blocks. It has turned out to be a very essential part for the efficient operation of the facility. Major causes for equipment downtime were associated with the control system, the beryllium target system, RF and magnet systems and the treatment gantry. (author)

  4. Investigation on the neutron beam characteristics for boron neutron capture therapy with 3D and 2D transport calculations

    International Nuclear Information System (INIS)

    Kodeli, I.; Diop, C.M.; Nimal, J.C.

    1994-01-01

    In the framework of future Boron Neutron Capture Therapy (BNCT) experiments, where cells and animals irradiations are planned at the research reactor of Strasbourg University, the feasibility to obtain a suitable epithermal neutron beam is investigated. The neutron fluence and spectra calculations in the reactor are performed using the 3D Monte Carlo code TRIPOLI-3 and the 2D SN code TWODANT. The preliminary analysis of Al 2 O 3 and Al-Al 2 O 3 filters configurations are carried out in an attempt to optimize the flux characteristics in the beam tube facility. 7 figs., 7 refs

  5. Cutaneous complication after electron beam therapy in breast cancer

    Directory of Open Access Journals (Sweden)

    M Jalilian

    2005-11-01

    Full Text Available Background: Breast cancer is the most common cancer in women and the second cause of death among them. There are several treatment methods for breast cancer, one of which is radiation therapy. There are two important methods of radiation therapy: tangential field and single oppositional field. Main goal of this study is evaluation of factors that have a role in producing acute side effects such as skin burning in breast cancer patients treated by electron beam,in order to decrease these side effects. Methods: From 1/2003 through 7/2004, 200 consecutive patients were evaluated during 18 months in seid-al-shohad hospital, whose mean age was 49 years old. In this study a questionnaire was used including some questions about personal profile such as patient's name, address, registration number, age and some other factors. All patients who were candidated to enter in this investigation filled out the questionnaire at the end of radiation therapy. The patients were examined and their skin burning grades were evaluated by RTOG scale. Data were analyzed by chi-square test using SPSS 11 software. Results: None of patients showed grades O or 4 of burning. 31.5 % of Patients showed grade 1, 64.5 % showed grade 2, 4 % showed grade 3 of burning. There was statistically significant correlation between posterior axillary field and skin burning and there wasnot any meaning between the other factors. Conclusion: It is necessary to pay more attention to posterior axillary field planning including field size, location, photon energy, depth and dose of treatment. Keywords: breast cancer, electron beam radiation therapy, skin burning

  6. Report on proton therapy according to good clinical practice at Hyogo Ion Beam Medical Center

    International Nuclear Information System (INIS)

    Murakami, Masao; Kagawa, Kazufumi; Hishikawa, Yoshio; Abe, Mitsuyuki

    2002-01-01

    The Hyogo Ion Beam Medical Center (HIBMC) is a hospital-based charged particle treatment facility. Having two treatment ion beams (proton and carbon) and five treatment rooms, it is a pioneer among particle institutes worldwide. In May 2001, proton therapy was started as a clinical study for patients with localized cancer originating in the head and neck, lung, liver, and prostate. The aim of this study was to investigate the safety, effectiveness, and stability of the treatment units and systems based on the evaluation of acute toxicity, tumor response, and working ratio of the machine, respectively. Six patients, including liver cancer in three, prostate cancer in two, and lung cancer in one, were treated. There was no cessation of therapy owing to machine malfunction. Full courses of proton therapy consisting of 154 portals in all six patients were given exactly as scheduled. None of the patients experienced severe acute reactions of more than grade 3 according to NCI-CTC criteria. Tumor response one month post-treatment was evaluable in five of the six patients, and was CR in 1 (prostate cancer), PR in 2 (lung cancer: 1, liver cancer: 1), and NC in 2 (liver cancer: 2). These results indicate that our treatment units and systems are safe and reliable enough for proton irradiation to be used for several malignant tumors localized in the body. (author)

  7. The design, fabrication and operation of the mechanical systems for the Neutral Beam Engineering Test Facility

    International Nuclear Information System (INIS)

    Patterson, J.A.; Fong, M.; Koehler, G.W.; Low, W.; Purgalis, P.; Wells, R.P.

    1983-01-01

    The Neutral Beam Engineering Test Facility (NBETF) at the Lawrence Berkeley Laboratory (LBL) is a National Test Facility used to develop long pulse Neutral Beam Sources. The Facility will test sources up to 120 keV, 50 A, with 30 s beam-on times with a 10% duty factor. For this application, an actively cooled beam dump is required and one has been constructed capable of dissipating a wide range of power density profiles. The flexibility of the design is achieved by utilizing a standard modular panel design which is incorporated into a moveable support structure comprised of eight separately controllable manipulator assemblies. The thermal hydraulic design of the panels permits the dissipation of 2 kW/cm 2 anywhere on the panel surface. The cooling water requirements of the actively cooled dump system are provided by the closed loop Primary High Pressure Cooling Water System. To minimize the operating costs of continuously running this high power system, a variable speed hydraulic drive is used for the main pump. During beam pulses, the pump rotates at high speed, then cycles to low speed upon completion of the beam shot. A unique neutralizer design has been installed into the NBETF beamline. This is a gun-drilled moveable brazed assembly which provides continuous armoring of the beamline near the source. The unit penetrates the source mounting valve during operation and retracts to permit the valve to close as needed. The beamline also has an inertially cooled duct calorimeter assembly. This assembly is a moveable hinged matrix of copper plates that can be used as a beam stop up to pulse lengths of 50 ms. The beamline is also equipped with many beam scraper plates of differing detail design and dissipation capabilities

  8. The beam monitor system for heavy ion shallow in tumor therapy

    International Nuclear Information System (INIS)

    Tang Bin; Hu Zhengguo; Xu Zhiguo; Mao Ruishi; Zhang Xueheng; Tu Xiaolin; Guo Zhongyan; Sun Zhiyu; Wang Meng; Xiao Guoqing; Xu Hushan

    2008-01-01

    The program of heavy ion shallow tumor therapy has been started. The beam monitor system for the therapy is described in this paper. It is composed of plastic scintillator, which used to monitor the stability of beam intensity and control the irradiation dose, and PPAC which is to measure the beam homogeneity in the irradiation area. This system has shown good performance in the clinic experiments of the shallow tumor therapy. (authors)

  9. Impact of Spot Size and Beam-Shaping Devices on the Treatment Plan Quality for Pencil Beam Scanning Proton Therapy

    International Nuclear Information System (INIS)

    Moteabbed, Maryam; Yock, Torunn I.; Depauw, Nicolas; Madden, Thomas M.; Kooy, Hanne M.; Paganetti, Harald

    2016-01-01

    Purpose: This study aimed to assess the clinical impact of spot size and the addition of apertures and range compensators on the treatment quality of pencil beam scanning (PBS) proton therapy and to define when PBS could improve on passive scattering proton therapy (PSPT). Methods and Materials: The patient cohort included 14 pediatric patients treated with PSPT. Six PBS plans were created and optimized for each patient using 3 spot sizes (∼12-, 5.4-, and 2.5-mm median sigma at isocenter for 90- to 230-MeV range) and adding apertures and compensators to plans with the 2 larger spots. Conformity and homogeneity indices, dose-volume histogram parameters, equivalent uniform dose (EUD), normal tissue complication probability (NTCP), and integral dose were quantified and compared with the respective PSPT plans. Results: The results clearly indicated that PBS with the largest spots does not necessarily offer a dosimetric or clinical advantage over PSPT. With comparable target coverage, the mean dose (D mean ) to healthy organs was on average 6.3% larger than PSPT when using this spot size. However, adding apertures to plans with large spots improved the treatment quality by decreasing the average D mean and EUD by up to 8.6% and 3.2% of the prescribed dose, respectively. Decreasing the spot size further improved all plans, lowering the average D mean and EUD by up to 11.6% and 10.9% compared with PSPT, respectively, and eliminated the need for beam-shaping devices. The NTCP decreased with spot size and addition of apertures, with maximum reduction of 5.4% relative to PSPT. Conclusions: The added benefit of using PBS strongly depends on the delivery configurations. Facilities limited to large spot sizes (>∼8 mm median sigma at isocenter) are recommended to use apertures to reduce treatment-related toxicities, at least for complex and/or small tumors.

  10. Monitoring the electron beam position at the TESLA test facility free electron laser

    International Nuclear Information System (INIS)

    Kamps, T.

    2000-01-01

    The operation of a free electron laser working in the Self Amplified Spontaneous Emission mode (SASE FEL) requires the electron trajectory to be aligned with very high precision in overlap with the photon beam. In order to ensure this overlap, one module of the SASE FEL undulator at the TESLA Test Facility (TTF) is equipped with a new type of waveguide beam position monitor (BPM). Four waveguides are arranged symmetrically around the beam pipe, each channel couples through a small slot to the electromagnetic beam field. The induced signal depends on the beam intensity and on the transverse beam position in terms of beam-to-slot distance. With four slot--waveguide combinations a linear position sensitive signal can be achieved, which is independent of the beam intensity. The signals transduced by the slots are transferred by ridged waveguides through an impedance matching stage into a narrowband receiver tuned to 12 GHz. The present thesis describes design, tests, and implementation of this new type of BPM. (orig.)

  11. Facility for the testing of the TFTR prototype neutral beam injector

    Energy Technology Data Exchange (ETDEWEB)

    Haughian, J.M.

    1977-07-01

    The design of the prototype neutral beam injection system for TFTR is nearing completion at the Lawrence Livermore Laboratory. This paper describes some of the features of the facility at the Lawrence Berkeley Laboratory where this prototype will be assembled and tested.

  12. Physics at a future Neutrino Factory and super-beam facility

    NARCIS (Netherlands)

    Bandyopadhyay, A.; Choubey, S.; Gandhi, R.; Goswami, S.; Roberts, B. L.; Bouchez, J.; Antoniadis, I.; Ellis, J.; Giudice, G. F.; Schwetz, T.; Umasankar, S.; Karagiorgi, G.; Aguilar-Arevalo, A.; Conrad, J. M.; Shaevitz, M. H.; Pascoli, S.; Geer, S.; Campagne, J. E.; Rolinec, M.; Blondel, A.; Campanelli, M.; Kopp, J.; Lindner, M.; Peltoniemi, J.; Dornan, P. J.; Long, K.; Matsushita, T.; Rogers, C.; Uchida, Y.; Dracos, M.; Whisnant, K.; Casper, D.; Chen, Mu-Chun; Popov, B.; Aysto, J.; Marfatia, D.; Okada, Y.; Sugiyama, H.; Jungmann, K.; Lesgourgues, J.; Zisman, M.; Tortola, M. A.; Friedland, A.; Davidson, S.; Antusch, S.; Biggio, C.; Donini, A.; Fernandez-Martinez, E.; Gavela, B.; Maltoni, M.; Lopez-Pavon, J.; Rigolin, S.; Mondal, N.; Palladino, V.; Filthaut, F.; Albright, C.; de Gouvea, A.; Kuno, Y.; Nagashima, Y.; Mezzetto, M.; Lola, S.; Langacker, P.; Baldini, A.; Nunokawa, H.; Meloni, D.; Diaz, M.; King, S. F.; Zuber, K.; Akeroyd, A. G.; Grossman, Y.; Farzan, Y.; Tobe, K.; Aoki, Mayumi; Murayama, H.; Kitazawa, N.; Yasuda, O.; Petcov, S.; Romanino, A.; Chimenti, P.; Vacchi, A.; Smirnov, A. Yu; Couce, E.; Gomez-Cadenas, J. J.; Hernandez, P.; Sorel, M.; Valle, J. W. F.; Harrison, P. F.; Lunardini, C.; Nelson, J. K.; Barger, V.; Everett, L.; Huber, P.; Winter, W.; Fetscher, W.; van der Schaaf, A.

    2009-01-01

    The conclusions of the Physics Working Group of the International Scoping Study of a future Neutrino Factory and super-beam facility (the ISS) are presented. The ISS was carried out by the international community between NuFact05, (the 7th International Workshop on Neutrino Factories and

  13. Producing National Ignition Facility (NIF)-quality beams on the Nova and Beamlet lasers

    International Nuclear Information System (INIS)

    Widmayer, C.C.; Auerbach, J.M.; Ehrlich, R.B.

    1996-08-01

    The Nova and Beamlet lasers were used to simulate the beam propagation conditions that will be encountered during the National Ignition Facility operation. Perturbation theory predicts that there is a 5mm scale length propagation mode that experiences large nonlinear power growth. This mode was observed in the tests. Further tests have confirmed that this mode can be suppressed with improved spatial filtering

  14. Facility for the testing of the TFTR prototype neutral beam injector

    International Nuclear Information System (INIS)

    Haughian, J.M.

    1977-07-01

    The design of the prototype neutral beam injection system for TFTR is nearing completion at the Lawrence Livermore Laboratory. This paper describes some of the features of the facility at the Lawrence Berkeley Laboratory where this prototype will be assembled and tested

  15. Selection of carbon beam therapy: biophysical models of carbon beam therapy.

    Science.gov (United States)

    Matsufuji, Naruhiro

    2018-03-01

    Variation in the relative biological effectiveness (RBE) within the irradiation field of a carbon beam makes carbon-ion radiotherapy unique and advantageous in delivering the therapeutic dose to a deep-seated tumor, while sparing surrounding normal tissues. However, it is crucial to consider the RBE, not only in designing the dose distribution during treatment planning, but also in analyzing the clinical response retrospectively. At the National Institute of Radiological Sciences, the RBE model was established based on the response of human salivary gland cells. The response was originally handled with a linear-quadratic model, and later with a microdosimetric kinetic model. Retrospective analysis with a tumor-control probability model of non-small cell cancer treatment revealed a steep dose response in the tumor, and that the RBE of the tumor was adequately estimated using the model. A commonly used normal tissue complication probability model has not yet fully been accountable for the variable RBE of carbon ions; however, analysis of rectum injury after prostate cancer treatment suggested a highly serial-organ structure for the rectum, and a steep dose response similar to that observed for tumors.

  16. Fast optimization and dose calculation in scanned ion beam therapy

    International Nuclear Information System (INIS)

    Hild, S.; Graeff, C.; Trautmann, J.; Kraemer, M.; Zink, K.; Durante, M.; Bert, C.

    2014-01-01

    Purpose: Particle therapy (PT) has advantages over photon irradiation on static tumors. An increased biological effectiveness and active target conformal dose shaping are strong arguments for PT. However, the sensitivity to changes of internal geometry complicates the use of PT for moving organs. In case of interfractionally moving objects adaptive radiotherapy (ART) concepts known from intensity modulated radiotherapy (IMRT) can be adopted for PT treatments. One ART strategy is to optimize a new treatment plan based on daily image data directly before a radiation fraction is delivered [treatment replanning (TRP)]. Optimizing treatment plans for PT using a scanned beam is a time consuming problem especially for particles other than protons where the biological effective dose has to be calculated. For the purpose of TRP, fast optimization and fast dose calculation have been implemented into the GSI in-house treatment planning system (TPS) TRiP98. Methods: This work reports about the outcome of a code analysis that resulted in optimization of the calculation processes as well as implementation of routines supporting parallel execution of the code. To benchmark the new features, the calculation time for therapy treatment planning has been studied. Results: Compared to the original version of the TPS, calculation times for treatment planning (optimization and dose calculation) have been improved by a factor of 10 with code optimization. The parallelization of the TPS resulted in a speedup factor of 12 and 5.5 for the original version and the code optimized version, respectively. Hence the total speedup of the new implementation of the authors' TPS yielded speedup factors up to 55. Conclusions: The improved TPS is capable of completing treatment planning for ion beam therapy of a prostate irradiation considering organs at risk in this has been overseen in the review process. Also see below 6 min

  17. Salvage proton beam therapy for recurrent iris melanoma: outcome and side effects.

    Science.gov (United States)

    Riechardt, Aline I; Klein, Julian P; Cordini, Dino; Heufelder, Jens; Rehak, Matus; Seibel, Ira; Joussen, Antonia M

    2018-02-20

    This study aims to analyze the effect of salvage proton beam therapy for the treatment of recurrent iris melanoma. In this clinical case series, we retrospectively analyzed the data of eight patients who underwent proton beam therapy of the whole anterior segment as salvage therapy between 2000 and 2016 for recurrent iris melanoma after resection, ruthenium brachytherapy, or sector proton beam therapy. Two patients received salvage proton beam therapy for repeated tumor relapse. All patients were observed and prepared for proton beam therapy at the Charité and irradiated at the Helmholtz-Zentrum Berlin where they received 50 cobalt Gray equivalents (CGE) in four daily fractions. We investigated survival rates and ocular outcome. Median follow-up after salvage proton beam therapy was 39 months. No local recurrence was detected during follow-up. One patient died from hepatic metastases 5.5 years after salvage therapy. Secondary glaucoma occurred in seven out of eight patients during follow-up. Two patients had chronic corneal erosion and two other patients presented with corneal decompensation, necessitating Descemet membrane endothelial keratoplasty (DMEK), and perforating keratoplasty. Median visual acuity was 0.2 logMAR before salvage proton beam therapy and 0.7 logMAR at the end of follow-up. Whole anterior segment salvage proton beam therapy has effectively controlled recurrent iris melanoma in our patients, but has been associated with a high incidence of radiation-induced corneal impairment and secondary glaucoma requiring extensive secondary treatment.

  18. A fast atomic oxygen beam facility with in situ testing/analysis capabilities

    Science.gov (United States)

    Kinoshita, H.; Ikeda, J.; Tagawa, M.; Umeno, M.; Ohmae, N.

    1998-06-01

    A fast atomic oxygen beam facility consisting of a beam source, a mass spectrometer, an Auger electron spectroscope, a scanning tunneling microscope, and a friction tester has been developed to investigate interaction of energetic atomic oxygen with solid surfaces. The fast atomic oxygen beam has been characterized by time of flight distribution, quadrupole mass spectrometry, and quartz crystal microbalance. The time of flight distribution of the beam has shown that the average translational energy of the atomic oxygen beam reaches 4.7 eV and that the full width at half-maximum is 5.5 eV. A flux of the atomic oxygen is calculated from the frequency shift of the quartz crystal microbalance with silver electrodes, and typical flux of the atomic oxygen beam being 4.0×1012atoms/cm2 s. The flux of atomic oxygen of this source is fairly low, but is corresponding to that in the altitude of 500 km in low Earth orbit. The surface sensitive analysis methods equipped with the facility, such as Auger electron spectroscopy and scanning tunneling microscopy, have provided changes in the surface composition and morphology caused by the atomic oxygen exposure, without receiving any effect of ambient air. The ultrahigh vacuum friction tester especially designed for this facility is used to measure tribological properties of solid lubricants under the atomic oxygen exposures. Such in situ testing capability of this facility enables fundamental research for understanding the reaction scheme of atomic oxygen as well as engineering-oriented research for obtaining high reliability of the space systems.

  19. Preliminary design of safety and interlock system for indian test facility of diagnostic neutral beam

    Energy Technology Data Exchange (ETDEWEB)

    Tyagi, Himanshu, E-mail: htyagi@iter-india.org [ITER-India, Institute For Plasma Research, Bhat, Gandhinagar, Gujarat (India); Soni, Jignesh [Institute For Plasma Research, Bhat, Gandhinagar, Gujarat (India); Yadav, Ratnakar; Bandyopadhyay, Mainak; Rotti, Chandramouli [ITER-India, Institute For Plasma Research, Bhat, Gandhinagar, Gujarat (India); Gahlaut, Agrajit [Institute For Plasma Research, Bhat, Gandhinagar, Gujarat (India); Joshi, Jaydeep; Parmar, Deepak [ITER-India, Institute For Plasma Research, Bhat, Gandhinagar, Gujarat (India); Bansal, Gourab; Pandya, Kaushal; Chakraborty, Arun [Institute For Plasma Research, Bhat, Gandhinagar, Gujarat (India)

    2016-11-15

    Highlights: • Indian Test Facility being built to characterize DNB for ITER delivery. • Interlock system required to safeguard the investment incurred in building the facility and protecting ITER deliverable components. • Interlock levels upto 3IL-3 identified. • Safety instrumented system for occupational safety being designed. Safety I&C functions of SIL-2 identified. • The systems are based on ITER PIS and PSS design guidelines. - Abstract: Indian Test Facility (INTF) is being built in Institute For Plasma Research to characterize Diagnostic Neutral Beam in co-operation with ITER Organization. INTF is a complex system which consists of several plant systems like beam source, gas feed, vacuum, cryogenics, high voltage power supplies, high power RF generators, mechanical systems and diagnostics systems. Out of these, several INTF components are ITER deliverable, that is, beam source, beam line components and power supplies. To ensure successful operation of INTF involving integrated operation of all the constituent plant systems a matured Data Acquisition and Control System (DACS) is required. The INTF DACS is based on CODAC platform following on PCDH (Plant Control Design Handbook) guidelines. The experimental phases involve application of HV power supplies (100 KV) and High RF power (∼800 KW) which will produce energetic beam of maximum power 6MW within the facility for longer durations. Hence the entire facility will be exposed tohigh heat fluxes and RF radiations. To ensure investment protection and to provide occupational safety for working personnel a matured Safety and Interlock system is required for INTF. The Safety and Interlock systems are high-reliability I&C systems devoted completely to the specific functions. These systems will be separate from the conventional DACS of INTF which will handle the conventional control and acquisition functions. Both, the Safety and Interlock systems are based on IEC 61511 and IEC 61508 standards as

  20. Preliminary design of safety and interlock system for indian test facility of diagnostic neutral beam

    International Nuclear Information System (INIS)

    Tyagi, Himanshu; Soni, Jignesh; Yadav, Ratnakar; Bandyopadhyay, Mainak; Rotti, Chandramouli; Gahlaut, Agrajit; Joshi, Jaydeep; Parmar, Deepak; Bansal, Gourab; Pandya, Kaushal; Chakraborty, Arun

    2016-01-01

    Highlights: • Indian Test Facility being built to characterize DNB for ITER delivery. • Interlock system required to safeguard the investment incurred in building the facility and protecting ITER deliverable components. • Interlock levels upto 3IL-3 identified. • Safety instrumented system for occupational safety being designed. Safety I&C functions of SIL-2 identified. • The systems are based on ITER PIS and PSS design guidelines. - Abstract: Indian Test Facility (INTF) is being built in Institute For Plasma Research to characterize Diagnostic Neutral Beam in co-operation with ITER Organization. INTF is a complex system which consists of several plant systems like beam source, gas feed, vacuum, cryogenics, high voltage power supplies, high power RF generators, mechanical systems and diagnostics systems. Out of these, several INTF components are ITER deliverable, that is, beam source, beam line components and power supplies. To ensure successful operation of INTF involving integrated operation of all the constituent plant systems a matured Data Acquisition and Control System (DACS) is required. The INTF DACS is based on CODAC platform following on PCDH (Plant Control Design Handbook) guidelines. The experimental phases involve application of HV power supplies (100 KV) and High RF power (∼800 KW) which will produce energetic beam of maximum power 6MW within the facility for longer durations. Hence the entire facility will be exposed tohigh heat fluxes and RF radiations. To ensure investment protection and to provide occupational safety for working personnel a matured Safety and Interlock system is required for INTF. The Safety and Interlock systems are high-reliability I&C systems devoted completely to the specific functions. These systems will be separate from the conventional DACS of INTF which will handle the conventional control and acquisition functions. Both, the Safety and Interlock systems are based on IEC 61511 and IEC 61508 standards as

  1. Target diagnostics for commissioning the AWE HELEN Laser Facility 100 TW chirped pulse amplification beam

    Science.gov (United States)

    Eagleton, R. T.; Clark, E. L.; Davies, H. M.; Edwards, R. D.; Gales, S.; Girling, M. T.; Hoarty, D. J.; Hopps, N. W.; James, S. F.; Kopec, M. F.; Nolan, J. R.; Ryder, K.

    2006-10-01

    The capability of the HELEN laser at the Atomic Weapons Establishment Aldermaston has been enhanced by the addition of a short-pulse laser beam to augment the twin opposing nanosecond time scale beams. The short-pulse beam utilizes the chirped pulse amplification (CPA) technique and is capable of delivering up to 60J on target in a 500fs pulse, around 100TW, at the fundamental laser wavelength of 1.054μm. During the commissioning phase a number of diagnostic systems have been fielded, these include: x-ray pinhole imaging of the laser heated spot, charged particle time of flight, thermoluminescent dosimeter array, calibrated radiochromic film, and CR39 nuclear track detector. These diagnostic systems have been used to verify the performance of the CPA beam to achieve a focused intensity of around 1019Wcm-2 and to underwrite the facility radiological safety system.

  2. Research advances in proton beam therapy for hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    DAI Shuyang

    2013-10-01

    Full Text Available Hepatocellular carcinoma (HCC, one of the most common malignancies with high prevalence and mortality rate, usually results in poor prognosis and limited survival. A comprehensive analysis on the number and location of tumors, Child-Pugh grade, and Barcelona Clinic Liver Cancer stage will help the development of suitable treatment programs and improve prediction of prognosis. A majority of patients are complicated by cirrhosis, enlarged tumor, multiple lesions, vascular invasion, and even cancer embolus in the portal vein. With the growth of knowledge about the radiation tolerance of normal tissue and the advances in radiotherapy techniques, radiotherapy has become an important tool for step-down therapy and adjuvant therapy for liver cancer. Proton beam therapy (PBT is emerging as a novel radiotherapy for the management of HCC, which, benefiting from the effect of Bragg Peak from PBT, effectively decreases the toxicity of traditional radiotherapies to the liver and does little harm to the uninvolved liver tissue or the surrounding structures while intensifying the destruction in targeted malignant lesions. Furthermore, several previous studies on the treatment of HCC with PBT revealed excellent local control. The distinctive biophysical attributes of PBT in the treatment of HCC, as well as the available literature regarding clinical outcomes and toxicity of using PBT for HCC, are reviewed. Current evidence provides limited indications for PBT, which suggests that further study on the relationship between liver function and PBT is required to gain further insight into its indication and standardization.

  3. Charged particle therapy with mini-segmented beams

    Directory of Open Access Journals (Sweden)

    F. Avraham eDilmanian

    2015-12-01

    Full Text Available One of the fundamental attributes of proton therapy and carbon ion therapy is the ability of these charged particles to spare tissue distal to the targeted tumor. This significantly reduces normal tissue toxicity and has the potential to translate to a wider therapeutic index. Although, in general, particle therapy also reduces dose to the proximal tissues, particularly in the vicinity of the target, dose to the skin and to other very superficial tissues tends to be higher than that of megavoltage x-rays. The methods presented here, namely Interleaved carbon minibeams and Radiosurgery with arrays of proton and light ion minibeams, both utilize beams segmented into arrays of parallel minibeams of about 0.3 mm incident beam size. These minibeam arrays spare tissues, as demonstrated by synchrotron x-ray experiments. An additional feature of particle minibeams is their gradual broadening due to multiple Coulomb scattering as they penetrate tissues. In the case of interleaved carbon minibeams, which do not broaden much, two arrays of planar carbon minibeams that remain parallel at target depth, are aimed at the target from 90º angles and made to interleave at the target to produce a solid radiation field within the target. As a result the surrounding tissues are exposed only to individual carbon minibeam arrays and are therefore spared. The method was used in four-directional geometry at the NASA Space Radiation Laboratory to ablate a 6.5-mm target in a rabbit brain at a single exposure with 40 Gy physical absorbed dose. Contrast-enhanced magnetic resonance imaging and histology six month later showed very focal target necrosis with nearly no damage to the surrounding brain. As for minibeams of protons and light ions, for which the minibeam broadening is substantial, measurements at MD Anderson Cancer Center in Houston, Texas, and Monte Carlo simulations showed that the broadening minibeams will merge with their neighbors at a certain tissue depth

  4. SU-E-T-400: Evaluation of Shielding and Activation at Two Pencil Beam Scanning Proton Facilities

    International Nuclear Information System (INIS)

    Remmes, N; Mundy, D; Classic, K; Beltran, C; Kruse, J; Herman, M; Stoker, J; Nelson, K; Bues, M

    2015-01-01

    Purpose: To verify acceptably low dose levels around two newly constructed identical pencil beam scanning proton therapy facilities and to evaluate accuracy of pre-construction shielding calculations. Methods: Dose measurements were taken at select points of interest using a WENDI-2 style wide-energy neutron detector. Measurements were compared to pre-construction shielding calculations. Radiation badges with neutron dose measurement capabilities were worn by personnel and also placed at points throughout the facilities. Seven neutron and gamma detectors were permanently installed throughout the facility, continuously logging data. Potential activation hazards have also been investigated. Dose rates near water tanks immediately after prolonged irradiation have been measured. Equipment inside the treatment room and accelerator vault has been surveyed and/or wipe tested. Air filters from air handling units, sticky mats placed outside of the accelerator vault, and water samples from the magnet cooling water loops have also been tested. Results: All radiation badges have been returned with readings below the reporting minimum. Measurements of mats, air filters, cooling water, wipe tests and surveys of equipment that has not been placed in the beam have all come back at background levels. All survey measurements show the analytical shielding calculations to be conservative by at least a factor of 2. No anomalous events have been identified by the building radiation monitoring system. Measurements of dose rates close to scanning water tanks have shown dose rates of approximately 10 mrem/hr with a half-life less than 5 minutes. Measurements around the accelerator show some areas with dose rates slightly higher than 10 mrem/hr. Conclusion: The shielding design is shown to be adequate. Measured dose rates are below those predicted by shielding calculations. Activation hazards are minimal except in certain very well defined areas within the accelerator vault and for objects

  5. New developments of 11C post-accelerated beams for hadron therapy and imaging

    Science.gov (United States)

    Augusto, R. S.; Mendonca, T. M.; Wenander, F.; Penescu, L.; Orecchia, R.; Parodi, K.; Ferrari, A.; Stora, T.

    2016-06-01

    Hadron therapy was first proposed in 1946 and is by now widespread throughout the world, as witnessed with the design and construction of the CNAO, HIT, PROSCAN and MedAustron treatment centres, among others. The clinical interest in hadron therapy lies in the fact that it delivers precision treatment of tumours, exploiting the characteristic shape (the Bragg peak) of the energy deposition in the tissues for charged hadrons. In particular, carbon ion therapy is found to be biologically more effective, with respect to protons, on certain types of tumours. Following an approach tested at NIRS in Japan [1], carbon ion therapy treatments based on 12C could be combined or fully replaced with 11C PET radioactive ions post-accelerated to the same energy. This approach allows providing a beam for treatment and, at the same time, to collect information on the 3D distributions of the implanted ions by PET imaging. The production of 11C ion beams can be performed using two methods. A first one is based on the production using compact PET cyclotrons with 10-20 MeV protons via 14N(p,α)11C reactions following an approach developed at the Lawrence Berkeley National Laboratory [2]. A second route exploits spallation reactions 19F(p,X)11C and 23Na(p,X)11C on a molten fluoride salt target using the ISOL (isotope separation on-line) technique [3]. This approach can be seriously envisaged at CERN-ISOLDE following recent progresses made on 11C+ production [4] and proven post-acceleration of pure 10C3/6+ beams in the REX-ISOLDE linac [5]. Part of the required components is operational in radioactive ion beam facilities or commercial medical PET cyclotrons. The driver could be a 70 MeV, 1.2 mA proton commercial cyclotron, which would lead to 8.1 × 10711C6+ per spill. This intensity is appropriate using 11C ions alone for both imaging and treatment. Here we report on the ongoing feasibility studies of such approach, using the Monte Carlo particle transport code FLUKA [6,7] to simulate

  6. New developments of {sup 11}C post-accelerated beams for hadron therapy and imaging

    Energy Technology Data Exchange (ETDEWEB)

    Augusto, R.S., E-mail: r.s.augusto@cern.ch [European Organization for Nuclear Research – CERN, 1211 Geneva 23 (Switzerland); Ludwig Maximilians – University of Munich, Munich (Germany); Mendonca, T.M.; Wenander, F. [European Organization for Nuclear Research – CERN, 1211 Geneva 23 (Switzerland); Penescu, L. [MedAustron GmbH, Wiener Neustadt (Austria); Orecchia, R. [CNAO – Centro Nazionale di Adroterapia Oncologica per il trattamento dei tumori, Pavia (Italy); Parodi, K. [Ludwig Maximilians – University of Munich, Munich (Germany); Ferrari, A.; Stora, T. [European Organization for Nuclear Research – CERN, 1211 Geneva 23 (Switzerland)

    2016-06-01

    Hadron therapy was first proposed in 1946 and is by now widespread throughout the world, as witnessed with the design and construction of the CNAO, HIT, PROSCAN and MedAustron treatment centres, among others. The clinical interest in hadron therapy lies in the fact that it delivers precision treatment of tumours, exploiting the characteristic shape (the Bragg peak) of the energy deposition in the tissues for charged hadrons. In particular, carbon ion therapy is found to be biologically more effective, with respect to protons, on certain types of tumours. Following an approach tested at NIRS in Japan [1], carbon ion therapy treatments based on {sup 12}C could be combined or fully replaced with {sup 11}C PET radioactive ions post-accelerated to the same energy. This approach allows providing a beam for treatment and, at the same time, to collect information on the 3D distributions of the implanted ions by PET imaging. The production of {sup 11}C ion beams can be performed using two methods. A first one is based on the production using compact PET cyclotrons with 10–20 MeV protons via {sup 14}N(p,α){sup 11}C reactions following an approach developed at the Lawrence Berkeley National Laboratory [2]. A second route exploits spallation reactions {sup 19}F(p,X){sup 11}C and {sup 23}Na(p,X){sup 11}C on a molten fluoride salt target using the ISOL (isotope separation on-line) technique [3]. This approach can be seriously envisaged at CERN-ISOLDE following recent progresses made on {sup 11}C{sup +} production [4] and proven post-acceleration of pure {sup 10}C{sup 3/6+} beams in the REX-ISOLDE linac [5]. Part of the required components is operational in radioactive ion beam facilities or commercial medical PET cyclotrons. The driver could be a 70 MeV, 1.2 mA proton commercial cyclotron, which would lead to 8.1 × 10{sup 711}C{sup 6+} per spill. This intensity is appropriate using {sup 11}C ions alone for both imaging and treatment. Here we report on the ongoing feasibility

  7. In-phantom spectra and dose distributions from a high-energy neutron therapy beam

    Energy Technology Data Exchange (ETDEWEB)

    Benck, S. E-mail: benck@fynu.ucl.ac.be; D' Errico, F.; Denis, J.-M.; Meulders, J.-P.; Nath, R.; Pitcher, E.J

    2002-01-01

    In radiotherapy with external beams, healthy tissues surrounding the target volumes are inevitably irradiated. In the case of neutron therapy, the estimation of dose to the organs surrounding the target volume is particularly challenging, because of the varying contributions from primary and secondary neutrons and photons of different energies. The neutron doses to tissues surrounding the target volume at the Louvain-la-Neuve (LLN) facility were investigated in this work. At LLN, primary neutrons have a broad spectrum with a mean energy of about 30 MeV. The transport of a 10x10 cm{sup 2} beam through a water phantom was simulated by means of the Monte Carlo code MCNPX. Distributions of energy-differential values of neutron fluence, kerma and kerma equivalent were estimated at different locations in a water phantom. The evolution of neutron dose and dose equivalent inside the phantom was deduced. Measurements of absorbed dose and of dose equivalent were then carried out in a water phantom using an ionization chamber and superheated drop detectors (SDDs). On the beam axis, the calculations agreed well with the ionization chamber data, but disagreed significantly from the SDD data due to the detector's under-response to neutrons above 20 MeV. Off the beam axis, the calculated absorbed doses were significantly lower than the ionization chamber readings, since gamma fields were not accounted for. The calculated data are doses from neutron-induced charge particles, and these agreed with the values measured by the photon-insensitive SDDs. When exposed to the degraded spectra off the beam axis, the SDD offered reliable estimates of the neutron dose equivalent.

  8. Compendium of Neutron Beam Facilities for High Precision Nuclear Data Measurements. Annex: Individual Reports

    International Nuclear Information System (INIS)

    2014-07-01

    The recent advances in the development of nuclear science and technology, demonstrating the globally growing economy, require highly accurate, powerful simulations and precise analysis of the experimental results. Confidence in these results is still determined by the accuracy of the atomic and nuclear input data. For studying material response, neutron beams produced from accelerators and research reactors in broad energy spectra are reliable and indispensable tools to obtain high accuracy experimental results for neutron induced reactions. The IAEA supports the accomplishment of high precision nuclear data using nuclear facilities in particular, based on particle accelerators and research reactors around the world. Such data are essential for numerous applications in various industries and research institutions, including the safety and economical operation of nuclear power plants, future fusion reactors, nuclear medicine and non-destructive testing technologies. The IAEA organized and coordinated the technical meeting Use of Neutron Beams for High Precision Nuclear Data Measurements, in Budapest, Hungary, 10–14 December 2012. The meeting was attended by participants from 25 Member States and three international organizations — the European Organization for Nuclear Research (CERN), the Joint Research Centre (JRC) and the Organisation for Economic Co-operation and Development (OECD) Nuclear Energy Agency (OECD/NEA). The objectives of the meeting were to provide a forum to exchange existing know-how and to share the practical experiences of neutron beam facilities and associated instrumentation, with regard to the measurement of high precision nuclear data using both accelerators and research reactors. Furthermore, the present status and future developments of worldwide accelerator and research reactor based neutron beam facilities were discussed. This publication is a summary of the technical meeting and additional materials supplied by the international

  9. Compendium of Neutron Beam Facilities for High Precision Nuclear Data Measurements

    International Nuclear Information System (INIS)

    2014-07-01

    The recent advances in the development of nuclear science and technology, demonstrating the globally growing economy, require highly accurate, powerful simulations and precise analysis of the experimental results. Confidence in these results is still determined by the accuracy of the atomic and nuclear input data. For studying material response, neutron beams produced from accelerators and research reactors in broad energy spectra are reliable and indispensable tools to obtain high accuracy experimental results for neutron induced reactions. The IAEA supports the accomplishment of high precision nuclear data using nuclear facilities in particular, based on particle accelerators and research reactors around the world. Such data are essential for numerous applications in various industries and research institutions, including the safety and economical operation of nuclear power plants, future fusion reactors, nuclear medicine and non-destructive testing technologies. The IAEA organized and coordinated the technical meeting Use of Neutron Beams for High Precision Nuclear Data Measurements, in Budapest, Hungary, 10–14 December 2012. The meeting was attended by participants from 25 Member States and three international organizations — the European Organization for Nuclear Research (CERN), the Joint Research Centre (JRC) and the Organisation for Economic Co-operation and Development (OECD) Nuclear Energy Agency (OECD/NEA). The objectives of the meeting were to provide a forum to exchange existing know-how and to share the practical experiences of neutron beam facilities and associated instrumentation, with regard to the measurement of high precision nuclear data using both accelerators and research reactors. Furthermore, the present status and future developments of worldwide accelerator and research reactor based neutron beam facilities were discussed. This publication is a summary of the technical meeting and additional materials supplied by the international

  10. Deuteron beam interaction with lithium jet in a neutron source test facility

    International Nuclear Information System (INIS)

    Hassanein, A.

    1996-01-01

    Testing and evaluating candidate fusion reactor materials in a high-flux, high-energy neutron environment are critical to the success and economic feasibility of a fusion device. The current understanding of materials behavior in fission-like environments and existing fusion facilities is insufficient to ensure the necessary performance of future fusion reactor components. An accelerator-based deuterium-lithium system to generate the required high neutron flux for material testing is considered to be the most promising approach in the near future. In this system, a high-energy (30-40 MeV) deuteron beam impinges on a high-speed (10-20 m/s) lithium jet to produce the high-energy (≥14 MeV) neutrons required to simulate a fusion environment via the Li (d,n) nuclear stripping reaction. Interaction of the high-energy deuteron beam and the subsequent response of the high-speed lithium jet are evaluated in detail. Deposition of the deuteron beam, jet-thermal hydraulic response, lithium-surface vaporization rate, and dynamic stability of the jet are modeled. It is found that lower beam kinetic energies produce higher surface temperature and consequently higher Li vaporization rates. Larger beam sizes significantly reduce both bulk and surface temperatures. Thermal expansion and dynamic velocities (normal to jet direction) due to beam energy deposition and momentum transfer are much lower than jet flow velocity and decrease substantially at lower beam current densities. (orig.)

  11. Electron beam therapy with coil-generated magnetic fields

    International Nuclear Information System (INIS)

    Nardi, Eran; Barnea, Gideon; Ma, Chang-Ming

    2004-01-01

    This paper presents an initial study on the issues involved in the practical implementation of the use of transverse magnetic fields in electron beam therapy. By using such magnetic fields the dose delivered to the tumor region can increase significantly relative to that deposited to the healthy tissue. Initially we calculated the magnetic fields produced by the Helmholtz coil and modified Helmholtz coil configurations. These configurations, which can readily be used to generate high intensity magnetic fields, approximate the idealized magnetic fields studied in our previous publications. It was therefore of interest to perform a detailed study of the fields produced by these configurations. Electron beam dose distributions for 15 MeV electrons were calculated using the ACCEPTM code for a 3T transverse magnetic field produced by the modified Helmholtz configuration. The dose distribution was compared to those obtained with no magnetic field. The results were similar to those obtained in our previous work, where an idealized step function magnetic field was used and a 3T field was shown to be the optimal field strength. A simpler configuration was also studied in which a single external coil was used to generate the field. Electron dose distributions are also presented for a given geometry and given magnetic field strength using this configuration. The results indicate that this method is more difficult to apply to radiotherapy due to its lack of symmetry and its irregularity. For the various configurations dealt with here, a major problem is the need to shield the magnetic field in the beam propagation volume, a topic that must be studied in detail

  12. MedAustron - Ion-Beam Therapy and Research Center

    International Nuclear Information System (INIS)

    Schreiner, Thomas; Seemann, Rolf

    2015-01-01

    MedAustron is a synchrotron-based light-ion beam therapy center for cancer treatment as well as for clinical and non-clinical research, currently in the commissioning phase in Wiener Neustadt, Austria. Recently, the first proton beam was transported successfully to one of the four irradiation rooms. Whilst the choice of basic machine parameters was driven by medical requirements, i.e. 60 MeV protons and 120 MeV/A to 400 MeV/A carbon ions, the accelerator complex design was also optimized to offer flexibility for research operation. The potential of the synchrotron is being exploited to increase the maximum proton energy far beyond the medical needs to up to 800 MeV, for experimental physics applications, mainly in the areas of proton scattering and detector research. The accelerator layout allows for the installation of up to four ion source-spectrometer units, to provide various ion types besides the clinical used protons and carbon ions. Besides experimental physics, the two main non-clinical research disciplines are medical radiation physics and radiation biology. To decouple research and medical operation, a dedicated irradiation room for non-clinical research was included providing the installation of different experiments. In addition, several labs have been equipped with appropriate devices for preparing and analyzing radio-biological samples. This presentation gives a status overview over the whole project and highlights the non-clinical research opportunities at MedAustron. (Author)

  13. Transcript of the workshop to discuss plans for a National High Intensity Radioactive Nuclear Beam Facility

    International Nuclear Information System (INIS)

    Nitschke, J.M.

    1989-01-01

    Following the ''First International Conference on Radioactive Nuclear Beams'' in Berkeley, a workshop was held on October 19, 1989 at the Lawrence Berkeley Laboratory to discuss plans for a National High Intensity Radioactive Nuclear Beam (RNB) Facility. The purpose of the workshop was -- after having discussed during the conference the physics question that can be addressed with RNBs -- to evaluate more concretely the possibilities for actually constructing such a facility in this country. It is becoming increasingly apparent that facility producing beams of radioactive nuclei with extreme neutron-to-proton ratios is of high scientific interest and technically feasible. It would allow the study of nuclear structure and astrophysical reactions very far from the line of stable nuclei, and could provide new possibilities of reaching the long-sought island of stability of superheavy nuclei. Such facilities are under advanced consideration in Japan and at CERN in Europe. This paper contains a slightly edited transcript of the tape recording that was made of the workshop

  14. The Proton Beams for the New Time-of-Flight Neutron Facility at the CERN-PS

    CERN Document Server

    Cappi, R; Métral, G

    2000-01-01

    The experimental determination of neutron cross sections in fission and capture reactions as a function of the neutron energy is of primary importance in nuclear physics. Recent developments at CERN and elsewhere have shown that many fields of research and development, such as the design of Accelerator-Driven Systems (ADS) for nuclear waste incineration, nuclear astrophysics, fundamental nuclear physics, dosimetry for radiological protection and therapy, would benefit from a better knowledge of neutron cross sections. A neutron facility at the CERN-PS has been proposed with the aim of carrying out a systematic and high resolution study of neutron cross sections through Time-Of-Flight (n-TOF) measurement. The facility requires a high intensity proton beam (about 0.7x1013 particles/bunch) distributed in a short bunch (about 25 ns total length) to produce the neutrons by means of a spallation process in a lead target. To achieve these characteristics, a number of complex beam gymnastics have to be performed. All...

  15. Test facility for the development of 150-keV, multi-megawatt neutral beam systems

    International Nuclear Information System (INIS)

    Haughian, W.; Baker, W.R.; Biagi, L.A.; Hopkins, D.B.

    1975-11-01

    The next generation of CTR experiments, such as the Tokamak Fusion Test Reactor (TFTR), will require neutral-beam injection systems that produce multi-megawatt, 120-keV deuterium-beam pulses of 0.5-second duration. Since present injection systems are operating in the 10- to 40-keV range, an intensive development effort is in progress to meet a 150-keV requirement. The vacuum system and power supplies that make up a test facility to be used in the development of these injectors are described

  16. The CERN n_TOF Facility: Neutron Beams Performances for Cross Section Measurements

    CERN Document Server

    Chiaveri, E; Andrzejewski, J; Audouin, L; Barbagallo, M; Bécares, V; Bečvář, F; Belloni, F; Berthoumieux, E; Billowes, J; Boccone, V; Bosnar, D; Brugger, M; Calviani, M; Calviño, F; Cano-Ott, D; Carrapiço, C; Cerutti, F; Chin, M; Colonna, N; Cortés, G; Cortés-Giraldo, M A; Diakaki, M; Domingo-Pardo, C; Duran, I; Dressler, R; Dzysiuk, N; Eleftheriadis, C; Ferrari, A; Fraval, K; Ganesan, S; García, A R; Giubrone, G; Gómez-Hornillos, M B; Gonçalves, I F; González-Romero, E; Griesmayer, E; Guerrero, C; Gunsing, F; Gurusamy, P; Hernández-Prieto, A; Jenkins, D G; Jericha, E; Kadi, Y; Käppeler, F; Karadimos, D; Kivel, N; Koehler, P; Kokkoris, M; Krtička, M; Kroll, J; Lampoudis, C; Langer, C; Leal-Cidoncha, E; Lederer, C; Leeb, H; Leong, L S; Losito, R; Mallick, A; Manousos, A; Marganiec, J; Martínez, T; Massimi, C; Mastinu, P F; Mastromarco, M; Meaze, M; Mendoza, E; Mengoni, A; Milazzo, P M; Mingrone, F; Mirea, M; Mondalaers, W; Paradela, C; Pavlik, A; Perkowski, J; Plompen, A; Praena, J; Quesada, J M; Rauscher, T; Reifarth, R; Riego, A; Robles, M S; Roman, F; Rubbia, C; Sabaté-Gilarte, M; Sarmento, R; Saxena, A; Schillebeeckx, P; Schmidt, S; Schumann, D; Tagliente, G; Tain, J L; Tarrío, D; Tassan-Got, L; Tsinganis, A; Valenta, S; Vannini, G; Variale, V; Vaz, P; Ventura, A; Versaci, R; Vermeulen, M J; Vlachoudis, V; Vlastou, R; Wallner, A; Ware, T; Weigand, M; Weiss, C; Wright, T; Žugec, P

    2014-01-01

    This paper presents the characteristics of the existing CERN n\\_TOF neutron beam facility (n\\_TOF-EAR1 with a flight path of 185 meters) and the future one (n\\_TOF EAR-2 with a flight path of 19 meters), which will operate in parallel from Summer 2014. The new neutron beam will provide a 25 times higher neutron flux delivered in 10 times shorter neutron pulses, thus offering more powerful capabilities for measuring small mass, low cross section and/or high activity samples.

  17. Fast Pencil Beam Dose Calculation for Proton Therapy Using a Double-Gaussian Beam Model.

    Science.gov (United States)

    da Silva, Joakim; Ansorge, Richard; Jena, Rajesh

    2015-01-01

    The highly conformal dose distributions produced by scanned proton pencil beams (PBs) are more sensitive to motion and anatomical changes than those produced by conventional radiotherapy. The ability to calculate the dose in real-time as it is being delivered would enable, for example, online dose monitoring, and is therefore highly desirable. We have previously described an implementation of a PB algorithm running on graphics processing units (GPUs) intended specifically for online dose calculation. Here, we present an extension to the dose calculation engine employing a double-Gaussian beam model to better account for the low-dose halo. To the best of our knowledge, it is the first such PB algorithm for proton therapy running on a GPU. We employ two different parameterizations for the halo dose, one describing the distribution of secondary particles from nuclear interactions found in the literature and one relying on directly fitting the model to Monte Carlo simulations of PBs in water. Despite the large width of the halo contribution, we show how in either case the second Gaussian can be included while prolonging the calculation of the investigated plans by no more than 16%, or the calculation of the most time-consuming energy layers by about 25%. Furthermore, the calculation time is relatively unaffected by the parameterization used, which suggests that these results should hold also for different systems. Finally, since the implementation is based on an algorithm employed by a commercial treatment planning system, it is expected that with adequate tuning, it should be able to reproduce the halo dose from a general beam line with sufficient accuracy.

  18. Intraoperative electron beam radiation therapy (IOEBRT) for carcinoma of the exocrine pancreas

    International Nuclear Information System (INIS)

    Dobelbower, R.R. Jr.; Konski, A.A.; Merrick, H.W. III; Bronn, D.G.; Schifeling, D.; Kamen, C.

    1991-01-01

    The abdominal cavities of 50 patients were explored in a specially constructed intraoperative radiotherapy operating amphitheater at the Medical College of Ohio. Twenty-six patients were treated with intraoperative and postoperative precision high dose external beam therapy, 12 with intraoperative irradiation but no external beam therapy, and 12 with palliative surgery alone. All but two patients completed the postoperative external beam radiation therapy as initially prescribed. The median survival time for patients treated with palliative surgery alone was 4 months, and that for patients treated with intraoperative radiotherapy without external beam therapy was 3.5 months. Patients undergoing intraoperative irradiation and external beam radiation therapy had a median survival time of 10.5 months. Four patients died within 30 days of surgery and two patients died of gastrointestinal hemorrhage 5 months posttreatment

  19. Hadron-therapy beam monitoring: Towards a new generation of ultra-thin p-type silicon strip detectors

    Energy Technology Data Exchange (ETDEWEB)

    Bouterfa, M.; Aouadi, K. [Inst. of Information and Communication Technologies, Electronics and Applied Mathematics ICTEAM, Universite Catholique de Louvain, 1348 Louvain-la-Neuve (Belgium); Bertrand, D. [Particle Therapy Dept., Ion Beam Application IBA, 1348 Louvain-la-Neuve (Belgium); Olbrechts, B.; Delamare, R. [Inst. of Information and Communication Technologies, Electronics and Applied Mathematics ICTEAM, Universite Catholique de Louvain, 1348 Louvain-la-Neuve (Belgium); Raskin, J. P.; Gil, E. C. [Institut de Recherche en Mathematique et Physique IRMP, Universite Catholique de Louvain, 1348 Louvain-la-Neuve (Belgium); Flandre, D. [Inst. of Information and Communication Technologies, Electronics and Applied Mathematics ICTEAM, Universite Catholique de Louvain, 1348 Louvain-la-Neuve (Belgium)

    2011-07-01

    Hadron-therapy has gained increasing interest for cancer treatment especially within the last decade. System commissioning and quality assurance procedures impose to monitor the particle beam using 2D dose measurements. Nowadays, several monitoring systems exist for hadron-therapy but all show a relatively high influence on the beam properties: indeed, most devices consist of several layers of materials that degrade the beam through scattering and energy losses. For precise treatment purposes, ultra-thin silicon strip detectors are investigated in order to reduce this beam scattering. We assess the beam size increase provoked by the Multiple Coulomb Scattering when passing through Si, to derive a target thickness. Monte-Carlo based simulations show a characteristic scattering opening angle lower than 1 mrad for thicknesses below 20 {mu}m. We then evaluated the fabrication process feasibility. We successfully thinned down silicon wafers to thicknesses lower than 10 {mu}m over areas of several cm{sup 2}. Strip detectors are presently being processed and they will tentatively be thinned down to 20 {mu}m. Moreover, two-dimensional TCAD simulations were carried out to investigate the beam detector performances on p-type Si substrates. Additionally, thick and thin substrates have been compared thanks to electrical simulations. Reducing the pitch between the strips increases breakdown voltage, whereas leakage current is quite insensitive to strips geometrical configuration. The samples are to be characterized as soon as possible in one of the IBA hadron-therapy facilities. For hadron-therapy, this would represent a considerable step forward in terms of treatment precision. (authors)

  20. Hadron-therapy beam monitoring: Towards a new generation of ultra-thin p-type silicon strip detectors

    International Nuclear Information System (INIS)

    Bouterfa, M.; Aouadi, K.; Bertrand, D.; Olbrechts, B.; Delamare, R.; Raskin, J. P.; Gil, E. C.; Flandre, D.

    2011-01-01

    Hadron-therapy has gained increasing interest for cancer treatment especially within the last decade. System commissioning and quality assurance procedures impose to monitor the particle beam using 2D dose measurements. Nowadays, several monitoring systems exist for hadron-therapy but all show a relatively high influence on the beam properties: indeed, most devices consist of several layers of materials that degrade the beam through scattering and energy losses. For precise treatment purposes, ultra-thin silicon strip detectors are investigated in order to reduce this beam scattering. We assess the beam size increase provoked by the Multiple Coulomb Scattering when passing through Si, to derive a target thickness. Monte-Carlo based simulations show a characteristic scattering opening angle lower than 1 mrad for thicknesses below 20 μm. We then evaluated the fabrication process feasibility. We successfully thinned down silicon wafers to thicknesses lower than 10 μm over areas of several cm 2 . Strip detectors are presently being processed and they will tentatively be thinned down to 20 μm. Moreover, two-dimensional TCAD simulations were carried out to investigate the beam detector performances on p-type Si substrates. Additionally, thick and thin substrates have been compared thanks to electrical simulations. Reducing the pitch between the strips increases breakdown voltage, whereas leakage current is quite insensitive to strips geometrical configuration. The samples are to be characterized as soon as possible in one of the IBA hadron-therapy facilities. For hadron-therapy, this would represent a considerable step forward in terms of treatment precision. (authors)

  1. MOSFET dosimetry of the radiation therapy microbeams at the European synchrotron radiation facility

    International Nuclear Information System (INIS)

    Rozenfeld, A.; Lerch, M.

    2002-01-01

    Full text: We have developed an innovative on-line MOSFET readout system for use in the quality assurance of radiation treatment beams. Recently the system has found application in areas where excellent spatial resolution is also a requirement in the quality assurance process, for example IMRT, and microbeam radiation therapy. The excellent spatial resolution is achieved by using a quadruple RADFET TM chip in 'edge on' mode. In developing this approach we have found that the system can be utilised to determine any error in the beam profile measurements due to misalignment of RADFET with respect to the radiation beam or microbeam. Using this approach will ensure that the excellent spatial resolution of the RADFET used in 'edge-on' mode is fully utilised. In this work we report on dosimetry measurements performed at the microbeam radiation therapy beamline located at the European Synchrotron Radiation Facility. The synchrotron planar array microbeam with size 10-30 μm and pitch ∼200 μm has found an important application in microbeam radiation therapy (MRT) of brain tumours in infants for whom other kinds of radiotherapy are inadequate and/or unsafe. The radiation damage from an array of parallel microbeams correlates strongly with the range of peak-valley dose ratios (PVDR), ie, the range of the ratio of the absorbed dose to tissue directly in line with the mid-plane of the microbeam to that in the mid-plane between adjacent microbeams. Novel physical dosimetry of the microbeams using the online MOSFET reader system will be presented. Comparison of the experimental results with both GaF film measurements and Monte Carlo computer-simulated dosimetry are described here for selected points in the peak and valley regions of a microbeam-irradiated tissue phantom

  2. Development of neutron beam facilities for the Australian Replacement Research Reactor

    International Nuclear Information System (INIS)

    Kennedy, S.J.

    2002-01-01

    Full text: Australia is building a research reactor to replace the HIFAR reactor at Lucas Heights by the end of 2005. Like HIFAR, the replacement research reactor will be multipurpose with capabilities for both neutron beam research and radioisotope production. It will be a pool-type reactor with four times the neutron flux of HIFAR, a cold neutron source and large neutron guide hall. Cold and thermal neutrons will be transported to the neutron beam instruments with modern supermirror guides. INVAP SE has been contracted to build the reactor and associated infrastructure, with the exception of the neutron beam instruments. With conceptual design complete, detailed engineering is well advanced and site preparation has commenced. ANSTO is developing an initial suite of eight neutron beam instruments in close consultation with the Australian user community. Design of six of the neutron beam instruments is progressing well. The presentation will include a review the planned scientific capabilities, a description of the neutron beam facility and a status report on progress to date on the instrument development program

  3. Design Optimisation of a High Intensity Beam Facility and Feasibility Experiment of a Solid Fragmented Target

    CERN Document Server

    Charitonidis, Nikolaos; Rivkin, Leonid

    2014-06-13

    The present PhD thesis describes the design, execution and results of the HRMT-10 experiment performed at the HiRadMat facility of the CERN/SPS complex. The first part of the thesis covers the design optimization studies of the HiRadMat facility, focusing in particular on the radiation protection issues. A detailed Monte-Carlo model of the facility has been developed and validated through comparison with measurements. A very satisfactory agreement between the simulation and the experimental data is observed. In the second part of this thesis, a novel feasibility experiment of a fragmented solid target for a future Neutrino Factory or a Super Beam facility, able to support high beam powers ( 1 MW) is presented in detail. A solid granular target has been proposed as an interesting alternative to an open Hg jet target, presently considered as the baseline for such facilities, but posing considerable technical challenges. The HRMT-10 experiment seeks to address the lack of experimental data of the feasibility of...

  4. The CBS-The Most Cost Effective and High Performance Carbon Beam Source Dedicated for a New Generation Cancer Therapy

    CERN Document Server

    Kumada, Masayuki; Leivichev, E B; Parkhomchuk, Vasily; Podgorny, Fedor; Rastigeev, Sergey; Reva, Vladimir B; Skrinsky, Aleksander Nikolayevich; Vostrikov, Vladimir

    2005-01-01

    A Carbon ion beam is a superior tool to x-rays or a proton beam in both physical and biological doses in treating a cancer. A Carbon beam has an advantage in treating radiation resistant and deep-seated tumors. Its radiological effect is of a mitotic independent nature. These features improve hypofractionation, typically reducing the number of irradiations per patient from 35 to a few. It has been shown that a superior QOL(Quality Of Life) therapy is possible by a carbon beam.The only drawback is its high cost. Nevertheless, tens of Prefectures and organizations are eagerly considering the possibility of having a carbon ion therapy facility in Japan. Germany, Austria, Italy, China, Taiwan and Korea also desire to have one.A carbon beam accelerator of moderate cost is about 100 Million USD. With the "CBS" design philosophy, which will be described in this paper, the cost could be factor of 2 or 3 less, while improving its performance more than standard designs. Novel extraction techniques, a new approach to a ...

  5. ISABELLE: a 400 x 400 GeV proton--proton colliding beam facility

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-01-01

    A conceptual design report is presented for the construction of an Intersecting Storage Accelerator, ISABELLE, to be located at Brookhaven National Laboratory. At this major research facility beams of protons with energies up to 400 GeV will be collided in six experimental areas. At each area particle physicists will install detector apparatus to study the interaction and reaction products for such very high energy collisions. The proposal results from several years of study and development work on such a facility. Topics discussed include: (1) introduction and summary of the proposal; (2) physics at ISABELLE (including physics objectives and typical experiments and detectors); description of ISABELLE (overview; magnetic ring structure and lattice characteristics; performance; beam transfer, stacking, and acceleration; magnet system; refrigeration system; vacuum system; power supplies, instrumentation, and control system; physical plant and experimental halls; and operation and safety); and (3) cost estimate and schedule.

  6. The H line: a brand new beam line for fundamental physics at the J-PARC muon facility

    International Nuclear Information System (INIS)

    Kawamura, N; Shimomura, K; Miyake, Y; Toyoda, A; Saito, N; Mihara, S; Aoki, M

    2013-01-01

    The muon facility, J-PARC (Muon Science Establishment; MUSE), has been operated since first beam in 2008. Starting with a 200 kW proton beam, the beam intensity has reached 3×10 6 / muons/s, the most intense pulsed muon beam in the world. A 2 cm thick graphite target permits the extraction of four secondary muon beams. A brand new beam line, the H line, is planned to be constructed. The new beam line is designed to have a large acceptance, will provide the ability to tune the momentum, and use a kicker magnet and/or Wien filter. This beam line will provide an intense beam for experiments that require high statistics and must occupy the experimental areas for a relatively long period.

  7. The Radioactive Ion Beams in Brazil (RIBRAS) facility. Description, program, main results, future plans

    Science.gov (United States)

    Lépine-Szily, A.; Lichtenthäler, R.; Guimarães, V.

    2014-08-01

    RIBRAS (Radioactive Ion Beams in Brazil) is a facility installed at the Institute of Physics of the University of São Paulo (IFUSP), Brazil. The RIBRAS system consists of two superconducting solenoids and uses the "in-flight method" to produce radioactive ion beams using the primary beam provided by the 8UD Pelletron Tandem of IFUSP. The ion beams produced so far by RIBRAS are 6He, 8Li, 7Be, 10Be, 8B, 12B with intensities that can vary from 104 to 106 pps. Initially the experimental program covered the study of elastic and inelastic scattering with the objective to study the interaction potential and the reaction mechanisms between weakly bound (RIB) and halo (6He and 8B projectiles on light, medium and heavy mass targets. With highly purified beams, the study of resonant elastic scattering and resonant transfer reactions, using inverse kinematics and thick targets, has also been included in our experimental program. Also, transfer reactions of astrophysical interest and fusion reactions induced by halo nuclei are part of the near-future research program. Our recent results on elastic scattering, alpha-particle production and total reaction cross sections, as well as the resonant elastic and transfer reactions, are presented. Our plans for the near future are related to the installation of a new beam line and a cave for gamma-ray detection. We intend to place in operation a large area neutron detector available in our laboratory. The long-range plans could be the move of the RIBRAS system to the more energetic beam line of the LINAC post-accelerator (10MeV/nucleon primary beams) still in construction in our laboratory.

  8. The Radioactive Ion Beams in Brazil (RIBRAS) facility. Description, program, main results, future plans

    Energy Technology Data Exchange (ETDEWEB)

    Lepine-Szily, A.; Lichtenthaeler, R.; Guimaraes, V. [Instituto de Fisica, Universidade de Sao Paulo (Brazil)

    2014-08-15

    RIBRAS (Radioactive Ion Beams in Brazil) is a facility installed at the Institute of Physics of the University of Sao Paulo (IFUSP), Brazil. The RIBRAS system consists of two superconducting solenoids and uses the ''in-flight method'' to produce radioactive ion beams using the primary beam provided by the 8UD Pelletron Tandem of IFUSP. The ion beams produced so far by RIBRAS are {sup 6}He, {sup 8}Li, {sup 7}Be, {sup 10}Be, {sup 8}B, {sup 12}B with intensities that can vary from 10{sup 4} to 10{sup 6} pps. Initially the experimental program covered the study of elastic and inelastic scattering with the objective to study the interaction potential and the reaction mechanisms between weakly bound (RIB) and halo ({sup 6}He and {sup 8}B) projectiles on light, medium and heavy mass targets. With highly purified beams, the study of resonant elastic scattering and resonant transfer reactions, using inverse kinematics and thick targets, has also been included in our experimental program. Also, transfer reactions of astrophysical interest and fusion reactions induced by halo nuclei are part of the near-future research program. Our recent results on elastic scattering, alpha-particle production and total reaction cross sections, as well as the resonant elastic and transfer reactions, are presented. Our plans for the near future are related to the installation of a new beam line and a cave for gamma-ray detection. We intend to place in operation a large area neutron detector available in our laboratory. The long-range plans could be the move of the RIBRAS system to the more energetic beam line of the LINAC post-accelerator (10MeV/nucleon primary beams) still in construction in our laboratory. (orig.)

  9. Beam Position Monitor and Energy Analysis at the Fermilab Accelerator Science and Technology Facility

    Energy Technology Data Exchange (ETDEWEB)

    Lopez, David Juarez [Univ. of Guanajuato (Mexico)

    2015-08-01

    Fermilab Accelerator Science and Technology Facility has produced its first beam with an energy of 20 MeV. This energy is obtained by the acceleration at the Electron Gun and the Capture Cavity 2 (CC2). When fully completed, the accelerator will consist of a photoinjector, one International Liner Collider (ILC)-type cryomodule, multiple accelerator R&D beamlines, and a downstream beamline to inject 300 MeV electrons into the Integrable Optics Test Accelerator (IOTA). We calculated the total energy of the beam and the corresponding energy to the Electron Gun and CC2. Subsequently, a Beam Position Monitors (BPM) error analysis was done, to calculate the device actual resolution.

  10. Materials science and biophysics applications at the ISOLDE radioactive ion beam facility

    CERN Document Server

    Wahl, U

    2011-01-01

    The ISOLDE isotope separator facility at CERN provides a variety of radioactive ion beams, currently more than 800 different isotopes from ~65 chemical elements. The radioisotopes are produced on-line by nuclear reactions from a 1.4 GeV proton beam with various types of targets, outdiffusion of the reaction products and, if possible, chemically selective ionisation, followed by 60 kV acceleration and mass separation. While ISOLDE is mainly used for nuclear and atomic physics studies, applications in materials science and biophysics account for a significant part (currently ~15%) of the delivered beam time, requested by 18 different experiments. The ISOLDE materials science and biophysics community currently consists of ~80 scientists from more than 40 participating institutes and 21 countries. In the field of materials science, investigations focus on the study of semiconductors and oxides, with the recent additions of nanoparticles and metals, while the biophysics studies address the toxicity of metal ions i...

  11. Cavity beam position monitor system for the Accelerator Test Facility 2

    Directory of Open Access Journals (Sweden)

    Y. I. Kim

    2012-04-01

    Full Text Available The Accelerator Test Facility 2 (ATF2 is a scaled demonstrator system for final focus beam lines of linear high energy colliders. This paper describes the high resolution cavity beam position monitor (BPM system, which is a part of the ATF2 diagnostics. Two types of cavity BPMs are used, C-band operating at 6.423 GHz, and S-band at 2.888 GHz with an increased beam aperture. The cavities, electronics, and digital processing are described. The resolution of the C-band system with attenuators was determined to be approximately 250 nm and 1  μm for the S-band system. Without attenuation the best recorded C-band cavity resolution was 27 nm.

  12. Sustaining neutral beam power supply system for the Mirror Fusion Test Facility

    International Nuclear Information System (INIS)

    Eckard, R.D.; Wilson, J.H.; Van Ness, H.W.

    1980-01-01

    In late August 1978, a fixed price procurement contract for $25,000,000 was awarded to Aydin Energy Division, Palo Alto, California, for the design, manufacture, installation and acceptance testing of the Lawrence Livermore National Laboratory Mirror Fusion Test Facility (MFTF) Sustaining Neutral Beam Power Supply System (SNBPSS). This system of 24 power supply sets will provide the conditioned power for the 24 neutral beam source modules. Each set will provide the accel potential the arc power, the filament power, and the suppressor power for its associated neutral beam source module. The design and development of the SNBPSS has progressed through the final design phase and is now in production. Testing of the major sub-assembly power supply is proceeding at Aydin and the final acceptance testing of the first two power supplies at LLNL is expected to be completed this year

  13. Shield design for the material science beam line of medical proton cyclotron facility

    International Nuclear Information System (INIS)

    Sarangapani, R.; Meenakshisundaram, V.; Indira, R.; Subbaiah, K.V.

    2007-01-01

    A medical proton cyclotron facility is being commissioned by DAE in Kolkata. The facility will have three dedicated beam lines for i) the production of radioisotopes, ii) Accelerator Driven Systems (ADS) experiments and iii) material science studies. It is proposed to irradiate SS (D9 alloy) samples by Materials Science Division, IGCAR in the material science beam line. The proton energy and current are 30 MeV and 200 μA respectively. It is proposed to irradiate the sample for seven days and retrieve it after a minimum cooling period of 24 h. Proton-induced radionuclides are produced in the target during irradiation. In addition to the induced activity, protons impinging on the sample results in the emission of neutrons. The emitted neutrons interact with the structural materials and produces induced activity. The access to the area is permitted only during shutdown of the beam line and that too after sufficient cooling time. The irradiated target is transferred from irradiation chamber to lead transport cask. When the beam line is in the off state, neutrons are absent and the dose rate at the accessible locations is only from the gamma rays emitted by the target material and induced activity on the structural materials. Calculations have been carried out to estimate the required shielding thickness around the target so that the dose rate at the accessible locations is within acceptable levels. The shield thickness for the lead cask is also estimated. (author)

  14. The Beam Profile Monitoring System for the IRRAD Proton Facility at the CERN PS East Area

    CERN Document Server

    Gkotse, Blerina; Matli, Emanuele; Ravotti, Federico; Gan, Kock Kiam; Kagan, Harris; Smith, Shane; Warner, Joseph

    2016-01-01

    In High Energy Physics (HEP) experiments, devices are frequently required to withstand a certain radiation level. As a result, detectors and electronics must be irradiated to determine their level of radiation tolerance. To perform these irradiations, CERN built a new irradiation facility in the East Area at the Proton Synchrotron (PS) accelerator. At this facility, named IRRAD, a high-intensity 24 GeV/c proton beam is used. During irradiation, it is necessary to monitor the intensity and the transverse profile of the proton beam. The Beam Profile Monitor (BPM) for IRRAD uses 39-channel pixel detectors to monitor the beam position. These pixel detectors are constructed using thin foil copper pads positioned on a flex circuit. When protons pass through the copper pads, they induce a measurable current. To measure this current and determine the total flux of protons passing through the thin foil copper detectors, a new data acquisition system was designed as well as a new database and on-line display system. In...

  15. Facility to disinfect medical wastes by 10 MeV electron beam

    International Nuclear Information System (INIS)

    Kerluke, D.R.

    1998-01-01

    As regulations related to the disposal of infectious hospital and other medical waste are become increasingly stringent, hospitals and governments worldwide are looking to develop more effective and economical means to disinfect such waste materials prior to them being ultimately landfilled, incinerated or recycled. With the advent of reliable high-energy, high-power industrial electron accelerators, the prospect now exists to centralize collection of much of the infectious medical waste for major metropolitan areas at a single facility, and render it harmless using irradiation. Using much of the same or similar methodologies already developed for single-use medical device sterilization and for bioburden reduction in other goods, high energy electron beam treatment offers unique process advantages which become increasingly attractive with the economies of scale available at higher power. This paper will explore some of the key issues related to the safe disposition of infectious hospital and other medical waste, related irradiation research projects, and the design and economic factors related to an electron beam facility dedicated to this application. This will be presented in the context of the Rhodotron family of electron beam accelerators manufactured by Ion Beam Applications s.a. (author)

  16. Segmented beryllium target for a 2 MW super beam facility

    Directory of Open Access Journals (Sweden)

    T. Davenne

    2015-09-01

    Full Text Available The Long Baseline Neutrino Facility (LBNF, formerly the Long Baseline Neutrino Experiment is under design as a next generation neutrino oscillation experiment, with primary objectives to search for CP violation in the leptonic sector, to determine the neutrino mass hierarchy and to provide a precise measurement of θ_{23}. The facility will generate a neutrino beam at Fermilab by the interaction of a proton beam with a target material. At the ultimate anticipated proton beam power of 2.3 MW the target material must dissipate a heat load of between 10 and 25 kW depending on the target size. This paper presents a target concept based on an array of spheres and compares it to a cylindrical monolithic target such as that which currently operates at the T2K facility. Simulation results show that the proposed technology offers efficient cooling and lower stresses whilst delivering a neutrino production comparable with that of a conventional solid cylindrical target.

  17. Total skin electron beam therapy for cutaneous lymphomas and leukemias

    International Nuclear Information System (INIS)

    Nisce, L.Z.; Chu, F.C.H.; Lee, H.S.; Filippa, D.; Kempin, S.; Coleman, M.

    1982-01-01

    Total skin electron beam therapy (TSEB) was used in the treatment of 33 patients with lymphoma and 13 patients with leukemia involving extensive segments of the skin surface. Twenty-two of 23 had lesions as a primary manifestation of lymphoma (primary cutaneous lymphoma-PCL) and 11 developed cutaneous lesions following disseminated nodal lymphoma (secondary cutaneous lymphoma-SCL). A once weekly fractionation scheme was employed to irradiate the entire skin surface with 3.5 to 4 MeV electron beam from a 6 MeV linear accelerator. During each weekly session, 400 rad were delivered to the entire skin and a complete course consisted of 4-6 consecutive weekly sessions. The majority of patients have been previously treated elsewhere for various periods and all patients have been at risk for a median of 12 months, range from 12-117 months following TSEB. Striking predominance of the diffuse pattern (76%) was demonstrated in both the PCL and SCL. There was extracutaneous involvement in 63% (13/22) of the PCL, nodal or visceral at onset of TSEB; median follow-up was 24 months, range 6-117 months; 20/22 (90%) of all patients obtained prompt relief of symptoms and complete regression of cutaneous lesions. Duration of cutaneous remission ranged from 6-96 months, median 18 months; in general, duration was adversly influenced by the presence of visceral involvement at onset of TSEB. Although cutaneous response among the patients with SCL and leukemia was equally good, many of these patients were treated for palliation because of rapid progression of their disease. Once weekly treatments were highly effective, well-tolerated and no untoward immediate or late effects have been noted in the bone marrow or normal skin irradiated

  18. Radiological and the other safety aspects in the operation of electron beam facility

    International Nuclear Information System (INIS)

    Loterina, Roel Alamares

    2003-01-01

    The radiological safety aspects of the operation of an electron beam facility in general and the 3 MeV ALURTRON electron beam facility of the Malaysian Institute of Nuclear Technology Research (MINT) in particular were reviewed and evaluated. Evaluation was made based on existing records as well as actual monitoring around facility. Area monitoring results using TLDs are within permissible levels. The maximum reading of 7.29 mSv measured in year 2000 is very low as compared to the annual dose limit of 50 mSv/year. In general, the shielding for the installation is adequate and no significant radiation leakage were detected based on radiation survey results. However, measured radiation levels with a maximum of 1.9 mSv/h at the sampling ports easily exceed the limit of 25μSv/h. The facility is equipped with safety features, such as interlocked system, adequate shielding, engineered safety design of irradiation and accelerator rooms, and accessories such as conveyor system and product handling system. Warning lights and signals are adequately installed around the facility. Other identified hazards that may affect the operator, workers, and personnel were also evaluated based on previous records of monitoring. The ozone concentration levels with a maximum reading of 0.05 ppm measured in the environment of the facility are within the threshold limit value of 0.1 ppm. The measured noise levels at all locations around facility are generally below the maximum permissible level of 80dB. The ALURTRON has achieved a minimum safety requirement to warrant its full operation without relying on administrative controls and procedures to ensure safety in operation. (Auth.)

  19. LHCB: A LHCb-VELO module as beam quality monitor for proton therapy beam at the Clatterbridge Centre for Oncology

    CERN Multimedia

    Casse, G; Patel, G D; Smith, N A; Kacperek, A; Marsland, B

    2010-01-01

    The progress in detector technology, driven by the needs of particle tracking and vertexing in the present LHC and its upgrade (sLHC), has led to the design of silicon sensors with low mass, high granularity, high speed and unprecedented radiation hardness. The sensors designed for such a harsh environment can be profitably used for instrumenting the control systems of therapeutic hadron beams. The high granularity and readout clock speed are well suited for monitoring continuous beam currents. The low mass allows reduced interference with the beam whilst monitoring its profile with high precision. The high resolution and sensitivity to minimum ionising particles allows monitoring of the beam spot position by measurement of the halo in real time, without any interference with the beam spot used in therapy.

  20. Optimization study for an epithermal neutron beam for boron neutron capture therapy at the University of Virginia Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Burns, Jr., Thomas Dean [Univ. of Virginia, Charlottesville, VA (United States)

    1995-05-01

    The non-surgical brain cancer treatment modality, Boron Neutron Capture Therapy (BNCT), requires the use of an epithermal neutron beam. This purpose of this thesis was to design an epithermal neutron beam at the University of Virginia Research Reactor (UVAR) suitable for BNCT applications. A suitable epithermal neutron beam for BNCT must have minimal fast neutron and gamma radiation contamination, and yet retain an appreciable intensity. The low power of the UVAR core makes reaching a balance between beam quality and intensity a very challenging design endeavor. The MCNP monte carlo neutron transport code was used to develop an equivalent core radiation source, and to perform the subsequent neutron transport calculations necessary for beam model analysis and development. The code accuracy was validated by benchmarking output against experimental criticality measurements. An epithermal beam was designed for the UVAR, with performance characteristics comparable to beams at facilities with cores of higher power. The epithermal neutron intensity of this beam is 2.2 x 108 n/cm2 • s. The fast neutron and gamma radiation KERMA factors are 10 x 10-11cGy•cm2/nepi and 20 x 10-11 cGy•cm2/nepi , respectively, and the current-to-flux ratio is 0.85. This thesis has shown that the UVAR has the capability to provide BNCT treatments, however the performance characteristics of the final beam of this study were limited by the low core power.

  1. Radiation protection metrology at a high-energy neutron therapy facility

    International Nuclear Information System (INIS)

    Bonnett, D.E.; Sherwin, A.G.; More, B.R.

    1991-01-01

    A radiation protection survey has been carried out at a high-energy neutron therapy facility using a combination of different detectors and counters. Included in the survey were measurements with a tissue equivalent proportional counter (TEPC), a rem meter, a large volume ionisation chamber (LVI) and a Geiger counter. Dose equivalent rates, normalised to a proton beam current of 25 μA, of between 1 μSv.h -1 and 0.7 Sv.h -1 were recorded depending on the location. In general the results confirm the tendency of the rem meter to over-read in fields consisting mainly of low energy neutrons and illustrate the advantages of the diagnostic and gamma discriminating properties of the TEPC. The LVI-Geiger system was found to be the least favourable combination of dosemeters, substantially under-reading and being unable to estimate the neutron dose rate at levels below about 32 μGy.h -1 . (author)

  2. Development of picoseconds Time of Flight systems in Meson Test Beam Facility at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Ronzhin, A.; Albrow, M.; Demarteau, M.; Los, S.; /Fermilab; Malik, S.; /Rockefeller U.; Pronko, S.; Ramberg, E.; /Fermilab; Zatserklyaniy, A.; /Puerto Rico U., Mayaguez

    2010-11-01

    The goal of the work is to develop time of flight (TOF) system with about 10 picosecond time resolution in real beam line when start and stop counters separated by some distance. We name the distance as 'base' for the TOF. This 'real' TOF setup is different from another one when start and stop counters located next to each other. The real TOF is sensitive to beam momentum spread, beam divergence, etc. Anyway some preliminary measurements are useful with close placement of start and stop counter. We name it 'close geometry'. The work started about 2 years ago at Fermilab Meson Test Beam Facility (MTBF). The devices tested in 'close geometry' were Microchannel Plate Photomultipliers (MCP PMT) with Cherenkov radiators. TOF counters based on Silicon Photomultipliers (SiPms) with Cherenkov radiators also in 'close geometry' were tested. We report here new results obtained with the counters in the MTBF at Fermilab, including beam line data.

  3. Improvements in electron beam monitoring and heat flux flatness at the JUDITH 2-facility

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Thomas, E-mail: weber.th@gmx.de [Forschungszentrum Jülich, Institute of Energy and Climate Research, Jülich (Germany); Bürger, Andreas; Dominiczak, Karsten; Pintsuk, Gerald [Forschungszentrum Jülich, Institute of Energy and Climate Research, Jülich (Germany); Banetta, Stefano; Bellin, Boris [Fusion for Energy, Josep Pla, 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Mitteau, Raphael; Eaton, Russell [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France)

    2015-10-15

    Highlights: • Monitoring of the much faster electron beam motion by IR camera through a synchronized frame triggering. • Estimation of the heat flux generated by electron beam guns based on calorimetry and FEM simulations. • Consideration of the inclined electron beam loading of rectangular-shaped objects. - Abstract: Three beryllium-armoured small-scale mock-ups and one semi-prototype for the ITER first wall were tested by the electron beam facility JUDITH 2 at Forschungszentrum Jülich. Both testing campaigns with cyclic loads up to 2.5 MW/m{sup 2} are carried out in compliance with the extensive quality and management specifications of ITER Organization (IO) and Fusion for Energy (F4E). Several dedicated calibration experiments were performed before the actual testing in order to fulfil the testing requirements and tolerances. These quality requests have been the motivation for several experimental setup improvements. The most relevant results of these activities, being the electron beam monitoring and the heat flux flatness verification, will be presented.

  4. The Continuous Electron Beam Accelerator Facility: CEBAF at the Jefferson Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Leemann, Chrisoph; Douglas, David R; Krafft, Geoffrey A

    2001-08-01

    The Jefferson Laboratory's superconducting radiofrequency (srf) Continuous Electron Beam Accelerator Facility (CEBAF) provides multi-GeV continuous-wave (cw) beams for experiments at the nuclear and particle physics interface. CEBAF comprises two antiparallel linacs linked by nine recirculation beam lines for up to five passes. By the early 1990s, accelerator installation was proceeding in parallel with commissioning. By the mid-1990s, CEBAF was providing simultaneous beams at different but correlated energies up to 4 GeV to three experimental halls. By 2000, with srf development having raised the average cavity gradient up to 7.5 MV/m, energies up to nearly 6 GeV were routine, at 1-150 muA for two halls and 1-100 nA for the other. Also routine are beams of >75% polarization. Physics results have led to new questions about the quark structure of nuclei, and therefore to user demand for a planned 12 GeV upgrade. CEBAF's enabling srf technology is also being applied in other projects.

  5. Development of a Beam-based Phase Feedforward Demonstration at the CLIC Test Facility (CTF3)

    CERN Document Server

    AUTHOR|(CDS)2083344; Christian, Glenn

    The Compact Linear Collider (CLIC) is a proposal for a future linear electron--positron collider that could achieve collision energies of up to 3~TeV. In the CLIC concept the main high energy beam is accelerated using RF power extracted from a high intensity drive beam, achieving an accelerating gradient of 100~MV/m. This scheme places strict tolerances on the drive beam phase stability, which must be better than $0.2^\\circ$ at 12~GHz. To achieve the required phase stability CLIC proposes a high bandwidth (${>}17.5$~MHz), low latency drive beam ``phase feedforward'' (PFF) system. In this system electromagnetic kickers, powered by 500~kW amplifiers, are installed in a chicane and used to correct the phase by deflecting the beam on to longer or shorter trajectories. A prototype PFF system has been installed at the CLIC Test Facility, CTF3; the design, operation and commissioning of which is the focus of this work. Two kickers have been installed in the pre-existing chicane in the TL2 transfer line at CTF3 for t...

  6. Improvements in electron beam monitoring and heat flux flatness at the JUDITH 2-facility

    International Nuclear Information System (INIS)

    Weber, Thomas; Bürger, Andreas; Dominiczak, Karsten; Pintsuk, Gerald; Banetta, Stefano; Bellin, Boris; Mitteau, Raphael; Eaton, Russell

    2015-01-01

    Highlights: • Monitoring of the much faster electron beam motion by IR camera through a synchronized frame triggering. • Estimation of the heat flux generated by electron beam guns based on calorimetry and FEM simulations. • Consideration of the inclined electron beam loading of rectangular-shaped objects. - Abstract: Three beryllium-armoured small-scale mock-ups and one semi-prototype for the ITER first wall were tested by the electron beam facility JUDITH 2 at Forschungszentrum Jülich. Both testing campaigns with cyclic loads up to 2.5 MW/m 2 are carried out in compliance with the extensive quality and management specifications of ITER Organization (IO) and Fusion for Energy (F4E). Several dedicated calibration experiments were performed before the actual testing in order to fulfil the testing requirements and tolerances. These quality requests have been the motivation for several experimental setup improvements. The most relevant results of these activities, being the electron beam monitoring and the heat flux flatness verification, will be presented.

  7. Development of an external beam nuclear microprobe on the Aglae facility of the Louvre museum

    Energy Technology Data Exchange (ETDEWEB)

    Calligaro, T.; Dran, J.-C. E-mail: dran@culture.fr; Ioannidou, E.; Moignard, B.; Pichon, L.; Salomon, J

    2000-03-01

    The external beam line of our facility has been recently equipped with the focusing system previously mounted on a classical nuclear microprobe. When using a 0.1 {mu}m thick Si{sub 3}N{sub 4} foil for the exit window and flowing helium on the sample under analysis, a beam spot as small as 10 {mu}m is attainable at a distance of 3 mm from the window. Elemental micromapping is performed by mechanical scanning. An electronic device has been designed which allows XY scanning by moving the sample under the beam by steps down to 0.1 {mu}m. Beam monitoring is carried out by means of the weak X-ray signal emitted by the exit foil and detected by a specially designed Si(Li) detector cooled by Peltier effect. The characteristics of external beams of protons and alpha particles are evaluated by means of resonance scanning and elemental mapping of a grid. An example of application is presented, dealing with elemental micro-mapping of inclusions in gemstones.

  8. Instrumentation and Beam Dynamics Study of Advanced Electron-Photon Facility in Indiana University

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Tianhuan [Indiana Univ., Bloomington, IN (United States)

    2011-08-01

    The Advanced eLectron-PHoton fAcility (ALPHA) is a compact electron accelerator under construction and being commissioned at the Indiana University Center for Exploration of Energy and Matter (CEEM). In this thesis, we have studied the refurbished Cooler Injector Synchrotron (CIS) RF cavity using both the transmission line model and SUPERFISH simulation. Both low power and high power RF measurements have been carried out to characterize the cavity. Considering the performance limit of ferrite, we have designed a new ferrite loaded, co-axial quarter wave like cavity with similar structure but a more suitable ferrite material. We have also designed a traveling wave stripline kicker for fast extraction by POISSON and Microwave Studio. The strips geometry is trimmed to maximize the uniformity of the kicking field and match the impedance of the power cables. The time response simulation shows the kicker is fast enough for machine operation. The pulsed power supply requirement has also been specified. For the beam diagnosis in the longitudinal direction, we use a wideband Wall Gap Monitor (WGM) served in CIS. With proper shielding and amplification to get good WGM signal, we have characterized the injected and extracted beam signal in single pass commissioning, and also verified the debunching effect of the ALPHA storage ring. A modulation-demodulation signal processing method is developed to measure the current and longitudinal profile of injected beam. By scanning the dipole strength in the injection line, we have reconstructed the tomography of the longitudinal phase space of the LINAC beam. In the accumulation mode, ALPHA will be operated under a low energy and high current condition, where intra beam scattering (IBS) becomes a dominant effect on the beam emittance. A self consistent simulation, including IBS effect, gas scattering and linear coupling, has been carried out to calculate the emittance of the stored beam.

  9. Structural integrity assessment based on the HFR Petten neutron beam facilities

    International Nuclear Information System (INIS)

    Ohms, C.; Youtsos, A.G.; Idsert, P. van den

    2002-01-01

    Neutrons are becoming recognized as a valuable tool for structural-integrity assessment of industrial components and advanced materials development. Microstructure, texture and residual stress analyses are commonly performed by neutron diffraction and a joint CEN/ISO Pre-Standard for residual stress analysis is under development. Furthermore neutrons provide for defects analyses, i.e. precipitations, voids, pores and cracks, through small-angle neutron scattering (SANS) or radiography. At the High Flux Reactor, 12 beam tubes have been installed for the extraction of thermal neutrons for such applications. Two of them are equipped with neutron diffractometers for residual stress and structure determination and have been extensively used in the past. Several other facilities are currently being reactivated and upgraded. These include the SANS and radiography facilities as well as a powder diffractometer. This paper summarizes the main characteristics and current status of these facilities as well as recently investigated applications. (orig.)

  10. Structural integrity assessment based on the HFR Petten neutron beam facilities

    Science.gov (United States)

    Ohms, C.; Youtsos, A. G.; van den Idsert, P.

    Neutrons are becoming recognized as a valuable tool for structural-integrity assessment of industrial components and advanced materials development. Microstructure, texture and residual stress analyses are commonly performed by neutron diffraction and a joint CEN/ISO Pre-Standard for residual stress analysis is under development. Furthermore neutrons provide for defects analyses, i.e. precipitations, voids, pores and cracks, through small-angle neutron scattering (SANS) or radiography. At the High Flux Reactor, 12 beam tubes have been installed for the extraction of thermal neutrons for such applications. Two of them are equipped with neutron diffractometers for residual stress and structure determination and have been extensively used in the past. Several other facilities are currently being reactivated and upgraded. These include the SANS and radiography facilities as well as a powder diffractometer. This paper summarizes the main characteristics and current status of these facilities as well as recently investigated applications.

  11. Structural integrity assessment based on the HFR Petten neutron beam facilities

    CERN Document Server

    Ohms, C; Idsert, P V D

    2002-01-01

    Neutrons are becoming recognized as a valuable tool for structural-integrity assessment of industrial components and advanced materials development. Microstructure, texture and residual stress analyses are commonly performed by neutron diffraction and a joint CEN/ISO Pre-Standard for residual stress analysis is under development. Furthermore neutrons provide for defects analyses, i.e. precipitations, voids, pores and cracks, through small-angle neutron scattering (SANS) or radiography. At the High Flux Reactor, 12 beam tubes have been installed for the extraction of thermal neutrons for such applications. Two of them are equipped with neutron diffractometers for residual stress and structure determination and have been extensively used in the past. Several other facilities are currently being reactivated and upgraded. These include the SANS and radiography facilities as well as a powder diffractometer. This paper summarizes the main characteristics and current status of these facilities as well as recently in...

  12. 3D printed plastics for beam modulation in proton therapy

    International Nuclear Information System (INIS)

    Lindsay, C; Hoehr, C; Kumlin, J; Schaffer, P; Jirasek, A; Lee, R; Martinez, D M

    2015-01-01

    Two 3D printing methods, fused filament fabrication (FFF) and PolyJet™ (PJ) were investigated for suitability in clinical proton therapy (PT) energy modulation. Measurements of printing precision, printed density and mean stopping power are presented. FFF is found to be accurate to 0.1 mm, to contain a void fraction of 13% due to air pockets and to have a mean stopping power dependent on geometry. PJ was found to print accurate to 0.05 mm, with a material density and mean stopping power consistent with solid poly(methyl methacrylate) (PMMA). Both FFF and PJ were found to print significant, sporadic defects associated with sharp edges on the order of 0.2 mm. Site standard PT modulator wheels were printed using both methods. Measured depth-dose profiles with a 74 MeV beam show poor agreement between PMMA and printed FFF wheels. PJ printed wheel depth-dose agreed with PMMA within 1% of treatment dose except for a distal falloff discrepancy of 0.5 mm. (note)

  13. Early experience of proton beam therapy combined with chemotherapy for locally advanced oropharyngeal cancer

    International Nuclear Information System (INIS)

    Ishikawa, Youjirou; Nakamura, Tatsuya; Takada, Akinori; Takayama, Kanako; Makita, Chiyoko; Suzuki, Motohisa; Azami, Yusuke; Kikuchi, Yasuhiro; Fuwa, Nobukazu

    2013-01-01

    Between 2009 and 2012, 10 patients with advanced oropharyngeal cancer underwent proton therapy combined with chemotherapy. The initial results of this therapy were 8 complete response (CR) and 2 partial response (PR), local recurrence was detected 1 patient. Proton beam therapy combined with chemotherapy is thought to be an effective treatment for locally advanced oropharyngeal cancer. (author)

  14. Potential applications of fusion neutral beam facilities for advanced material processing

    International Nuclear Information System (INIS)

    Williams, J.M.; Tsai, C.C.; Stirling, W.L.; Whealton, J.H.

    1994-01-01

    Surface processing techniques involving high energy ion implantation have achieved commercial success for semiconductors and biomaterials. However, wider use has been limited in good part by economic factors, some of which are related to the line-of-sight nature of the beam implantation process. Plasma source ion implantation is intended to remove some of the limitations imposed by directionality of beam systems and also to help provide economies of scale. The present paper will outline relevant technologies and areas of expertise that exist at Oak Ridge National Laboratory in relation to possible future needs in materials processing. Experience in generation of plasmas, control of ionization states, pulsed extraction, and sheath physics exists. Contributions to future technology can be made either for the immersion mode or for the extracted beam mode. Existing facilities include the High Power Test Facility, which could conservatively operate at 1 A of continuous current at 100 kV delivered to areas of about 1 m 2 . Higher instantaneous voltages and currents are available with a reduced duty cycle. Another facility, the High Heat Flux Facility can supply a maximum of 60 kV and currents of up to 60 A for 2 s on a 10% duty cycle. Plasmas may be generated by use of microwaves, radio-frequency induction or other methods and plasma properties may be tailored to suit specific needs. In addition to ion implantation of large steel components, foreseeable applications include ion implantation of polymers, ion implantation of Ti alloys, Al alloys, or other reactive surfaces

  15. In-phantom spectra and dose distributions from a high-energy neutron therapy beam

    CERN Document Server

    Benck, S; Denis, J M; Meulders, J P; Nath, R; Pitcher, E J

    2002-01-01

    In radiotherapy with external beams, healthy tissues surrounding the target volumes are inevitably irradiated. In the case of neutron therapy, the estimation of dose to the organs surrounding the target volume is particularly challenging, because of the varying contributions from primary and secondary neutrons and photons of different energies. The neutron doses to tissues surrounding the target volume at the Louvain-la-Neuve (LLN) facility were investigated in this work. At LLN, primary neutrons have a broad spectrum with a mean energy of about 30 MeV. The transport of a 10x10 cm sup 2 beam through a water phantom was simulated by means of the Monte Carlo code MCNPX. Distributions of energy-differential values of neutron fluence, kerma and kerma equivalent were estimated at different locations in a water phantom. The evolution of neutron dose and dose equivalent inside the phantom was deduced. Measurements of absorbed dose and of dose equivalent were then carried out in a water phantom using an ionization ch...

  16. Improving the beam quality of the neutron radiography facility using the SLOWPOKE-2 at the Royal Military College of Canada

    International Nuclear Information System (INIS)

    Lewis, W.J.; Bennett, L.G.I.; Teshima, P.

    1996-01-01

    At the SLOWPOKE-2 Facility at the Royal Military College of Canada, a neutron radiography facility has been designed and installed, and the beam quality has been improved by performing a series of radiographs using American standard for testing and materials (ASTM) E 545 indicators. Other means of determining the progress such as bubble detectors and activation foils were used. Modifications to the nosepiece of the beam tube including shielding and linings for fast neutron and gamma radiation were made. (orig.)

  17. Performance specifications for proton medical facility

    Energy Technology Data Exchange (ETDEWEB)

    Chu, W.T.; Staples, J.W.; Ludewigt, B.A.; Renner, T.R.; Singh, R.P.; Nyman, M.A.; Collier, J.M.; Daftari, I.K.; Petti, P.L.; Alonso, J.R. [Lawrence Berkeley Lab., CA (United States); Kubo, H.; Verhey, L.J. [University of California Davis Medical Center, Sacramento, CA (United States). Cancer Center]|[California Univ., San Francisco, CA (United States). School of Medicine; Castro, J.R. [Lawrence Berkeley Lab., CA (United States)]|[University of California Davis Medical Center, Sacramento, CA (United States). Cancer Center]|[California Univ., San Francisco, CA (United States). School of Medicine

    1993-03-01

    Performance specifications of technical components of a modern proton radiotherapy facility are presented. The technical items specified include: the accelerator; the beam transport system including rotating gantry; the treatment beamline systems including beam scattering, beam scanning, and dosimetric instrumentation; and an integrated treatment and accelerator control system. Also included are treatment ancillary facilities such as diagnostic tools, patient positioning and alignment devices, and treatment planning systems. The facility specified will accommodate beam scanning enabling the three-dimensional conformal therapy deliver .

  18. Proton Beam Therapy and Concurrent Chemotherapy for Esophageal Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Steven H., E-mail: shlin@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Komaki, Ritsuko; Liao Zhongxing [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wei, Caimiao [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Myles, Bevan [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Guo Xiaomao [Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai (China); Palmer, Matthew [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe [Department of Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Swisher, Stephen G.; Hofstetter, Wayne L. [Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Ajani, Jaffer A. [Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Cox, James D. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2012-07-01

    Purpose: Proton beam therapy (PBT) is a promising modality for the management of thoracic malignancies. We report our preliminary experience of treating esophageal cancer patients with concurrent chemotherapy (CChT) and PBT (CChT/PBT) at MD Anderson Cancer Center. Methods and Materials: This is an analysis of 62 esophageal cancer patients enrolled on a prospective study evaluating normal tissue toxicity from CChT/PBT from 2006 to 2010. Patients were treated with passive scattering PBT with two- or three-field beam arrangement using 180 to 250 MV protons. We used the Kaplan-Meier method to assess time-to-event outcomes and compared the distributions between groups using the log-rank test. Results: The median follow-up time was 20.1 months for survivors. The median age was 68 years (range, 38-86). Most patients were males (82%) who had adenocarcinomas (76%) and Stage II-III disease (84%). The median radiation dose was 50.4 Gy (RBE [relative biologic equivalence]) (range, 36-57.6). The most common grade 2 to 3 acute toxicities from CChT/PBT were esophagitis (46.8%), fatigue (43.6%), nausea (33.9%), anorexia (30.1%), and radiation dermatitis (16.1%). There were two cases of grade 2 and 3 radiation pneumonitis and two cases of grade 5 toxicities. A total of 29 patients (46.8%) received preoperative CChT/PBT, with one postoperative death. The pathologic complete response (pCR) rate for the surgical cohort was 28%, and the pCR and near CR rates (0%-1% residual cells) were 50%. While there were significantly fewer local-regional recurrences in the preoperative group (3/29) than in the definitive CChT/PBT group (16/33) (log-rank test, p = 0.005), there were no differences in distant metastatic (DM)-free interval or overall survival (OS) between the two groups. Conclusions: This is the first report of patients treated with PBT/CChT for esophageal cancer. Our data suggest that this modality is associated with a few severe toxicities, but the pathologic response and clinical

  19. Capability verification of the beam delivery system in the superficially-placed tumor therapy terminal at HIRFL

    International Nuclear Information System (INIS)

    Dai Zhongying; Li Qiang; Xiao Guoqing; Jin Xiaodong; Yan Zheng; Chinese Academy of Sciences, Beijing

    2007-01-01

    The passive beam delivery system in the superficially-placed tumor therapy terminal at Heavy Ion Research Facility in Lanzhou (HIRFL), which includes two orthogonal dipole magnets as scanning system, a motor-driven energy degrader as range-shifter, series of ridge filters as range modulator and a multileaf collimator, is introduced in detail. The capacities of its important components and the whole system have been verified experimentally. The tests of the ridge filter for extending Bragg peak and the range shifter for energy adjustment show both work well. To examine the passive beam delivery system, a beam shaping experiment were carried out, simulating a three-dimensional (3D) conformal irradiation to a tumor. The encouraging experimental result confirms that 3D layer-stacking conformal irradiation can be performed by means of the passive system. The validation of the beam delivery system establishes a substantial basis for upcoming clinical trial for superficially-placed tumors with heavy ions in the therapy terminal at HIRFL. (authors)

  20. Intraoperative electron beam therapy and external photon beam therapy with lumpectomy as primary treatment for early breast cancer

    International Nuclear Information System (INIS)

    Dobelbower, R.R.; Merrick, H.W.; Eltaki, A.; Bronn, D.G.

    1989-01-01

    Between 1984 and 1988, seven women with breast cancer were treated with intraoperative electron beam therapy (IOEBT). All patients were Caucasian. Patient age ranged from 37 to 62 (median 53) years. Histopathology was infiltrating duct carcinoma (6/7) or medullary carcinoma (1/7). Four tumors were staged T1 N0 MO, one T1 N1 MO, one T2 N1 MO, and one lesion was recurrent. At the time of primary lumpectomy or axillary node dissection, a dose of 10 or 15 Gy IOEBT was administered to the tumor bed with 6 or 9 MeV electrons through the lumpectomy wound. All patients received 45 or 50 Gy over five to six weeks with 6 MV photons to the breast and, in four patients, to the regional nodes. Three patients received adjuvant chemotherapy and tamoxifen. No post-operative complications were observed. All patients are alive as of August, 1989, with no evidence of recurrent disease. Excellent cosmesis is the rule. Clinical and technical aspects of treatment are presented along with the rationale for the use of IOEBT in the primary definitive radiotherapeutic management of early breast cancer

  1. Progress in the realization of the PRIMA neutral beam test facility

    Science.gov (United States)

    Toigo, V.; Boilson, D.; Bonicelli, T.; Piovan, R.; Hanada, M.; Chakraborty, A.; Agarici, G.; Antoni, V.; Baruah, U.; Bigi, M.; Chitarin, G.; Dal Bello, S.; Decamps, H.; Graceffa, J.; Kashiwagi, M.; Hemsworth, R.; Luchetta, A.; Marcuzzi, D.; Masiello, A.; Paolucci, F.; Pasqualotto, R.; Patel, H.; Pomaro, N.; Rotti, C.; Serianni, G.; Simon, M.; Singh, M.; Singh, N. P.; Svensson, L.; Tobari, H.; Watanabe, K.; Zaccaria, P.; Agostinetti, P.; Agostini, M.; Andreani, R.; Aprile, D.; Bandyopadhyay, M.; Barbisan, M.; Battistella, M.; Bettini, P.; Blatchford, P.; Boldrin, M.; Bonomo, F.; Bragulat, E.; Brombin, M.; Cavenago, M.; Chuilon, B.; Coniglio, A.; Croci, G.; Dalla Palma, M.; D'Arienzo, M.; Dave, R.; De Esch, H. P. L.; De Lorenzi, A.; De Muri, M.; Delogu, R.; Dhola, H.; Fantz, U.; Fellin, F.; Fellin, L.; Ferro, A.; Fiorentin, A.; Fonnesu, N.; Franzen, P.; Fröschle, M.; Gaio, E.; Gambetta, G.; Gomez, G.; Gnesotto, F.; Gorini, G.; Grando, L.; Gupta, V.; Gutierrez, D.; Hanke, S.; Hardie, C.; Heinemann, B.; Kojima, A.; Kraus, W.; Maeshima, T.; Maistrello, A.; Manduchi, G.; Marconato, N.; Mico, G.; Moreno, J. F.; Moresco, M.; Muraro, A.; Muvvala, V.; Nocentini, R.; Ocello, E.; Ochoa, S.; Parmar, D.; Patel, A.; Pavei, M.; Peruzzo, S.; Pilan, N.; Pilard, V.; Recchia, M.; Riedl, R.; Rizzolo, A.; Roopesh, G.; Rostagni, G.; Sandri, S.; Sartori, E.; Sonato, P.; Sottocornola, A.; Spagnolo, S.; Spolaore, M.; Taliercio, C.; Tardocchi, M.; Thakkar, A.; Umeda, N.; Valente, M.; Veltri, P.; Yadav, A.; Yamanaka, H.; Zamengo, A.; Zaniol, B.; Zanotto, L.; Zaupa, M.

    2015-08-01

    The ITER project requires additional heating by two neutral beam injectors, each accelerating to 1 MV a 40 A beam of negative deuterium ions, to deliver to the plasma a power of about 17 MW for one hour. As these requirements have never been experimentally met, it was recognized as necessary to setup a test facility, PRIMA (Padova Research on ITER Megavolt Accelerator), in Italy, including a full-size negative ion source, SPIDER, and a prototype of the whole ITER injector, MITICA, aiming to develop the heating injectors to be installed in ITER. This realization is made with the main contribution of the European Union, through the Joint Undertaking for ITER (F4E), the ITER Organization and Consorzio RFX which hosts the Test Facility. The Japanese and the Indian ITER Domestic Agencies (JADA and INDA) participate in the PRIMA enterprise; European laboratories, such as IPP-Garching, KIT-Karlsruhe, CCFE-Culham, CEA-Cadarache and others are also cooperating. Presently, the assembly of SPIDER is on-going and the MITICA design is being completed. The paper gives a general overview of the test facility and of the status of development of the MITICA and SPIDER main components at this important stage of the overall development; then it focuses on the latest and most critical issues, regarding both physics and technology, describing the identified solutions.

  2. Faraday cup dosimetry in a proton therapy beam without collimation

    International Nuclear Information System (INIS)

    Grusell, Erik; Isacsson, Ulf; Montelius, Anders; Medin, Joakim

    1995-01-01

    A Faraday cup in a proton beam can give an accurate measurement of the number of protons collected by the cup. It is shown that the collection efficiency with a proper design can be close to unity. To be able to calibrate an ionization chamber from such a measurement, as is recommended in some dosimetry protocols, the energy spectrum of the proton beam must be accurately known. This is normally not the case when the lateral beam extension is defined by collimators. Therefore a method for relating an ionization chamber measurement in an uncollimated beam to the total number of protons in the beam has been developed and is described together with experimental results from calibrating an ionization chamber using this method in the therapeutic beam in Uppsala. This method is applicable to ionization chambers of any shape and the accuracy is estimated to be 1.6% (1 SD). (Author)

  3. A low energy ion beam facility for mass spectrometer calibration: First results.

    Science.gov (United States)

    Meyer, Stefan; Tulej, Marek; Wurz, Peter

    2018-01-01

    The exploration of habitable environments around the gas giants in the Solar System is of major interest in upcoming planetary missions. Exactly this theme is addressed by the Jupiter Icy Moons Explorer (JUICE) mission of the European Space Agency (ESA), which will characterise Ganymede, Europa, and Callisto as planetary objects and potential habitats. The NIM, Neutral gas and Ion Mass spectrometer, is part of the PEP experiment and will be used to measure the chemical composition of the exospheres of the icy Jovian moons. We designed and developed a calibration facility (SATANS, Supersonic cATion and ANion Source), especially for use with the NIM instrument. In a first step, we established a low energy ion beam for positive ions in the range of 0.01-30 eV. Then we conducted beam velocity calibrations with a velocity uncertainty <5%, which provided exact settings and formulas for the cation beam velocity of different gas mixtures in the range of 1-15 km/s. In addition, first results are obtained by using the NIM prototype for direct ion beam measurements under realistic JUICE mission conditions, i.e., for velocities from 1 up to 7 km/s and even more.

  4. The beam slow extraction from a magnetic ring of Moscow meson facility

    International Nuclear Information System (INIS)

    Gusev, O.A.; Malitsky, N.D.; Severgin, Yu.P.; Titov, V.A.; Shukeilo, I.A.; Aseev, V.N.; Grachev, M.I.; Lobashev, V.M.; Ostroumov, P.N.; Ponomaryov, O.V.

    1990-01-01

    The beam slow extraction from the circular accelerators or stretcher rings is generally realized by the resonant excitation of betratron oscillations. A precise betatron frequency control is proved to be quite necessary for high-efficient slow ejection. The Coulomb field turns out to have a significant influence upon the slow extraction from the high-current medium energy proton storage rings. It prevents resonant excitation at a reasonable rate and reduces the ejection efficiency. The proton storage ring of Moscow meson facility is an example of a stretcher with a noticeable beam space charge. The detailed investigation of the resonant ejection, having been performed for our stretcher, resulted in the conclusion that extracted beam average current should be limited by the value of 50 mA, which is only 10% of the linac design current. The search for the alternative version to the resonant ejection made us to analyze in details and to develop an old-fashioned method, based on the radial betatron oscillation excitation while the beam is being gradually shifted onto the thin target. (author) 5 refs., 4 figs

  5. Radioactive ion beam facility at Louvain-La-Neuve, Belgium and its features

    International Nuclear Information System (INIS)

    Chintalapudi, S.N.

    1991-01-01

    Use of radioactive ion beams for the study of nuclear structure as well as the astrophysical reaction cross sections become the current interest in physics. A full-fledged facility based on two coupled cyclotrons comprising a compact high current cyclotron and a medium energy cyclotron with an intermediate target and ion source system has been recently commissioned at the Louvain-La-Neuve University in Belgium by its accelerator group and has been successfully used for the measurement of cross sections for the primordial nucleosynthesis reactions of astrophysical interest, directly. A brief description of the system, its operational features together with some details of the target and the ion source arrangement for the production of the radioactive ion beams and their acceleration to energies required for the proposed studies is presented. Description of the reactions studied by the Louvain La Neuve group for astrophysical interest is also given. (author). 20 refs., 6 figs., 4 tabs

  6. Accelerator characterization of the new ion beam facility at MTA Atomki in Debrecen, Hungary

    Science.gov (United States)

    Rajta, I.; Vajda, I.; Gyürky, Gy.; Csedreki, L.; Kiss, Á. Z.; Biri, S.; van Oosterhout, H. A. P.; Podaru, N. C.; Mous, D. J. W.

    2018-02-01

    In this work we present the 2 MV Tandetron accelerator manufactured by High Voltage Engineering Europa (HVEE), that was installed at MTA Atomki in Debrecen, Hungary in 2015. Furthermore, we report on the first performance test of the whole facility including the calibration of the terminal voltage using accurately known resonance energies of the 27Al(p, γ)28Si and 13C(p, γ)14N reactions, as well as neutron threshold energies of the 7Li(p,n)7Be and 13C(p,n)13N reactions. The accurate energy calibration of the generating voltmeter (GVM), the good energy stability of the accelerator as well as the low energy spread of the ion beam suited the requirements of nuclear astrophysics, resonance PIGE depth profiling and the nanoprobe beamline. We have investigated whether the terminal voltage reading depends on the insulating gas pressure, and how much the stripper gas pressure modifies the beam energy.

  7. Measurements of electron beam emittance in the Accelerator Test Facility damping ring operated in multibunch modes

    Directory of Open Access Journals (Sweden)

    Yosuke Honda

    2003-09-01

    Full Text Available We present the measurement results of electron beam emittance in the Accelerator Test Facility damping ring operated in multibunch modes. The measurements were carried out with an upgraded laser wire beam profile monitor. The monitor has now a vertical wire as well as a horizontal one and is able to make much faster measurements thanks to an increased effective laser power inside the cavity. The measured emittance shows no large bunch-to-bunch dependence in either the horizontal or vertical directions. The values of the vertical emittance are similar to those obtained in the single-bunch operation. The present results are an important step toward the realization of a high-energy linear collider.

  8. Numerical analysis of the beam position monitor pickup for the Iranian light source facility

    Science.gov (United States)

    Shafiee, M.; Feghhi, S. A. H.; Rahighi, J.

    2017-03-01

    In this paper, we describe the design of a button type Beam Position Monitor (BPM) for the low emittance storage ring of the Iranian Light Source Facility (ILSF). First, we calculate sensitivities, induced power and intrinsic resolution based on solving Laplace equation numerically by finite element method (FEM), in order to find the potential at each point of BPM's electrode surface. After the optimization of the designed BPM, trapped high order modes (HOM), wakefield and thermal loss effects are calculated. Finally, after fabrication of BPM, it is experimentally tested by using a test-stand. The results depict that the designed BPM has a linear response in the area of 2×4 mm2 inside the beam pipe and the sensitivity of 0.080 and 0.087 mm-1 in horizontal and vertical directions. Experimental results also depict that they are in a good agreement with numerical analysis.

  9. A low energy ion beam facility for mass spectrometer calibration: First results

    Science.gov (United States)

    Meyer, Stefan; Tulej, Marek; Wurz, Peter

    2018-01-01

    The exploration of habitable environments around the gas giants in the Solar System is of major interest in upcoming planetary missions. Exactly this theme is addressed by the Jupiter Icy Moons Explorer (JUICE) mission of the European Space Agency (ESA), which will characterise Ganymede, Europa, and Callisto as planetary objects and potential habitats. The NIM, Neutral gas and Ion Mass spectrometer, is part of the PEP experiment and will be used to measure the chemical composition of the exospheres of the icy Jovian moons. We designed and developed a calibration facility (SATANS, Supersonic cATion and ANion Source), especially for use with the NIM instrument. In a first step, we established a low energy ion beam for positive ions in the range of 0.01-30 eV. Then we conducted beam velocity calibrations with a velocity uncertainty mission conditions, i.e., for velocities from 1 up to 7 km/s and even more.

  10. Beam dynamics study in the C235 cyclotron for proton therapy

    International Nuclear Information System (INIS)

    Karamysheva, G.A.; Kostromin, S.A.

    2008-01-01

    Study of the beam dynamics in the C235 cyclotron dedicated to the proton therapy is presented. Results of the computer simulations of the particle motion in the measured magnetic field are given. Study of the resonance influence on the acceleration process was carried out. The corresponding tolerances on the magnetic field imperfections and transverse beam parameters were defined using these simulations

  11. Fast control and data acquisition in the neutral beam test facility

    Energy Technology Data Exchange (ETDEWEB)

    Luchetta, A., E-mail: adriano.luchetta@igi.cnr.it; Manduchi, G.; Taliercio, C.

    2014-05-15

    Highlights: • The paper describes the fast control and data acquisition in the ITER neutral beam test facility. • The usage of real time control in ion beam generation and extraction is proposed. • Real time management of breakdowns is described. • The implementation of event-driven data acquisition is reported. - Abstract: Fast control and data acquisition are required in the ion source test bed of the ITER neutral beam test facility, referred to as SPIDER. Fast control will drive the operation of the power supply systems with particular reference to special asynchronous events, such as the breakdowns. These are short-circuits among grids or between grids and vessel that can occur repeatedly during beam operation. They are normal events and, as such, they will be managed by the fast control system. Cycle time associated to such fast control is down to hundreds of microseconds. Fast data acquisition is required when breakdowns occur. Event-driven data acquisition is triggered in real time by fast control at the occurrence of each breakdown. Pre- and post-event samples are acquired, allowing capturing information on transient phenomena in a whole time-window centered on the event. Sampling rate of event-driven data acquisition is up to 5 MS/s. Fast data acquisition may also be independent of breakdowns as in the case of the cavity ring-down spectroscopy where data chunks are acquired at 100 MS/s in bursts of 1.5 ms every 100 ms and are processed in real time to produce derived measurements. The paper after the description of the SPIDER fast control and data acquisition application will report the system design based on commercially available hardware and the MARTe and MDSplus software frameworks. The results obtained by running a full prototype of the fast control and data acquisition system are also reported and discussed. They demonstrate that all SPIDER fast control and data acquisition requirements can be met in the prototype solution.

  12. Role of beam orientation optimization in intensity-modulated radiation therapy

    International Nuclear Information System (INIS)

    Pugachev, Andrei; Li, Jonathan G.; Boyer, Arthur L.; Hancock, Steven L.; Le, Quynh-Thu; Donaldson, Sarah S.; Lei Xing

    2001-01-01

    Purpose: To investigate the role of beam orientation optimization in intensity-modulated radiation therapy (IMRT) and to examine the potential benefits of noncoplanar intensity-modulated beams. Methods and Materials: A beam orientation optimization algorithm was implemented. For this purpose, system variables were divided into two groups: beam position (gantry and table angles) and beam profile (beamlet weights). Simulated annealing was used for beam orientation optimization and the simultaneous iterative inverse treatment planning algorithm (SIITP) for beam intensity profile optimization. Three clinical cases were studied: a localized prostate cancer, a nasopharyngeal cancer, and a paraspinal tumor. Nine fields were used for all treatments. For each case, 3 types of treatment plan optimization were performed: (1) beam intensity profiles were optimized for 9 equiangular spaced coplanar beams; (2) orientations and intensity profiles were optimized for 9 coplanar beams; (3) orientations and intensity profiles were optimized for 9 noncoplanar beams. Results: For the localized prostate case, all 3 types of optimization described above resulted in dose distributions of a similar quality. For the nasopharynx case, optimized noncoplanar beams provided a significant gain in the gross tumor volume coverage. For the paraspinal case, orientation optimization using noncoplanar beams resulted in better kidney sparing and improved gross tumor volume coverage. Conclusion: The sensitivity of an IMRT treatment plan with respect to the selection of beam orientations varies from site to site. For some cases, the choice of beam orientations is important even when the number of beams is as large as 9. Noncoplanar beams provide an additional degree of freedom for IMRT treatment optimization and may allow for notable improvement in the quality of some complicated plans

  13. SU-E-T-577: Obliquity Factor and Surface Dose in Proton Beam Therapy

    International Nuclear Information System (INIS)

    Das, I; Andersen, A; Coutinho, L

    2015-01-01

    Purpose: The advantage of lower skin dose in proton beam may be diminished creating radiation related sequalae usually seen with photon and electron beams. This study evaluates the surface dose as a complex function of beam parameters but more importantly the effect of beam angle. Methods: Surface dose in proton beam depends on the beam energy, source to surface distance, the air gap between snout and surface, field size, material thickness in front of surface, atomic number of the medium, beam angle and type of nozzle (ie double scattering, (DS), uniform scanning (US) or pencil beam scanning (PBS). Obliquity factor (OF) is defined as ratio of surface dose in 0° to beam angle Θ. Measurements were made in water phantom at various beam angles using very small microdiamond that has shown favorable beam characteristics for high, medium and low proton energy. Depth dose measurements were performed in the central axis of the beam in each respective gantry angle. Results: It is observed that surface dose is energy dependent but more predominantly on the SOBP. It is found that as SSD increases, surface dose decreases. In general, SSD, and air gap has limited impact in clinical proton range. High energy has higher surface dose and so the beam angle. The OF rises with beam angle. Compared to OF of 1.0 at 0° beam angle, the value is 1.5, 1.6, 1,7 for small, medium and large range respectively for 60 degree angle. Conclusion: It is advised that just like range and SOBP, surface dose should be clearly understood and a method to reduce the surface dose should be employed. Obliquity factor is a critical parameter that should be accounted in proton beam therapy and a perpendicular beam should be used to reduce surface dose

  14. Beam orientation optimization for intensity-modulated radiation therapy using mixed integer programming

    Energy Technology Data Exchange (ETDEWEB)

    Yang Ruijie [Department of Radiation Oncology, Cancer Hospital (Institute), Chinese Academy of Medical Sciences/Peking Union Medical College, PO Box 2258, Beijing 100021 (China); Dai Jianrong [Department of Radiation Oncology, Cancer Hospital (Institute), Chinese Academy of Medical Sciences/Peking Union Medical College, PO Box 2258, Beijing 100021 (China); Yang Yong [Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA 15232 (United States); Hu Yimin [Department of Radiation Oncology, Cancer Hospital (Institute), Chinese Academy of Medical Sciences/Peking Union Medical College, PO Box 2258, Beijing 100021 (China)

    2006-08-07

    The purpose of this study is to extend an algorithm proposed for beam orientation optimization in classical conformal radiotherapy to intensity-modulated radiation therapy (IMRT) and to evaluate the algorithm's performance in IMRT scenarios. In addition, the effect of the candidate pool of beam orientations, in terms of beam orientation resolution and starting orientation, on the optimized beam configuration, plan quality and optimization time is also explored. The algorithm is based on the technique of mixed integer linear programming in which binary and positive float variables are employed to represent candidates for beam orientation and beamlet weights in beam intensity maps. Both beam orientations and beam intensity maps are simultaneously optimized in the algorithm with a deterministic method. Several different clinical cases were used to test the algorithm and the results show that both target coverage and critical structures sparing were significantly improved for the plans with optimized beam orientations compared to those with equi-spaced beam orientations. The calculation time was less than an hour for the cases with 36 binary variables on a PC with a Pentium IV 2.66 GHz processor. It is also found that decreasing beam orientation resolution to 10{sup 0} greatly reduced the size of the candidate pool of beam orientations without significant influence on the optimized beam configuration and plan quality, while selecting different starting orientations had large influence. Our study demonstrates that the algorithm can be applied to IMRT scenarios, and better beam orientation configurations can be obtained using this algorithm. Furthermore, the optimization efficiency can be greatly increased through proper selection of beam orientation resolution and starting beam orientation while guaranteeing the optimized beam configurations and plan quality.

  15. Ion-optical studies for a range adaptation method in ion beam therapy using a static wedge degrader combined with magnetic beam deflection

    International Nuclear Information System (INIS)

    Chaudhri, Naved; Saito, Nami; Bert, Christoph; Franczak, Bernhard; Steidl, Peter; Durante, Marco; Schardt, Dieter; Rietzel, Eike

    2010-01-01

    Fast radiological range adaptation of the ion beam is essential when target motion is mitigated by beam tracking using scanned ion beams for dose delivery. Electromagnetically controlled deflection of a well-focused ion beam on a small static wedge degrader positioned between two dipole magnets, inside the beam delivery system, has been considered as a fast range adaptation method. The principle of the range adaptation method was tested in experiments and Monte Carlo simulations for the therapy beam line at the GSI Helmholtz Centre for Heavy Ions Research. Based on the simulations, ion optical settings of beam deflection and realignment of the adapted beam were experimentally applied to the beam line, and additional tuning was manually performed. Different degrader shapes were employed for the energy adaptation. Measured and simulated beam profiles, i.e. lateral distribution and range in water at isocentre, were analysed and compared with the therapy beam values for beam scanning. Deflected beam positions of up to ±28 mm on degrader were performed which resulted in a range adaptation of up to ±15 mm water equivalence (WE). The maximum deviation between the measured adapted range from the nominal range adaptation was below 0.4 mm WE. In experiments, the width of the adapted beam at the isocentre was adjustable between 5 and 11 mm full width at half maximum. The results demonstrate the feasibility/proof of the proposed range adaptation method for beam tracking from the beam quality point of view.

  16. Ion-optical studies for a range adaptation method in ion beam therapy using a static wedge degrader combined with magnetic beam deflection

    Science.gov (United States)

    Chaudhri, Naved; Saito, Nami; Bert, Christoph; Franczak, Bernhard; Steidl, Peter; Durante, Marco; Rietzel, Eike; Schardt, Dieter

    2010-06-01

    Fast radiological range adaptation of the ion beam is essential when target motion is mitigated by beam tracking using scanned ion beams for dose delivery. Electromagnetically controlled deflection of a well-focused ion beam on a small static wedge degrader positioned between two dipole magnets, inside the beam delivery system, has been considered as a fast range adaptation method. The principle of the range adaptation method was tested in experiments and Monte Carlo simulations for the therapy beam line at the GSI Helmholtz Centre for Heavy Ions Research. Based on the simulations, ion optical settings of beam deflection and realignment of the adapted beam were experimentally applied to the beam line, and additional tuning was manually performed. Different degrader shapes were employed for the energy adaptation. Measured and simulated beam profiles, i.e. lateral distribution and range in water at isocentre, were analysed and compared with the therapy beam values for beam scanning. Deflected beam positions of up to ±28 mm on degrader were performed which resulted in a range adaptation of up to ±15 mm water equivalence (WE). The maximum deviation between the measured adapted range from the nominal range adaptation was below 0.4 mm WE. In experiments, the width of the adapted beam at the isocentre was adjustable between 5 and 11 mm full width at half maximum. The results demonstrate the feasibility/proof of the proposed range adaptation method for beam tracking from the beam quality point of view.

  17. CEBAF/SURA [Continuous Electron Beam Accelerator Facility]/[Southeastern Universities Research Association] 1988 summer workshop

    International Nuclear Information System (INIS)

    Gross, F.; Lightbody, J.

    1989-01-01

    This report contains papers from a summer workshop of the continuous electron beam accelerator facility. Some topics of these papers are: spectrometers; electron scattering from deuterons; relativistic correlations in nuclear matter; pion production on 3 He and 3 H; quantum electrodynamic processes in crystals; 12 C(e,e'p) x reaction; deuteron polarization tensor and relativistic spin rotation; electromagnetic excitation of nuclei; electron distortion and structure functions in (e,e'p) reactions; and reaction mechanism of 4 He(e,e'p) 3 H

  18. The case for exotic beams at the Holifield Heavy Ion Research Facility

    International Nuclear Information System (INIS)

    Garrett, J.D.

    1991-01-01

    The case is presented for modifying the Holifield Heavy Ion Research Facility at Oak Ridge National Laboratory to provide beams of proton-rich exotic isotopes, that do not occur terrestrially. A program of nuclear structure studies for light- and medium-mass, nearly self-conjugate nuclei and for heavy, proton-rich, quasibound nuclei is outlined, as are studies of hydrogen-burning reactions that occur in nucleosynthetic processes. Such a scientific program will provide a unique future for nuclear physics research at ORNL consistent with the long standing tradition of this laboratory

  19. The n_TOF facility: Neutron beams for challenging future measurements at CERN

    Science.gov (United States)

    Chiaveri, E.; Aberle, O.; Andrzejewski, J.; Audouin, L.; Bacak, M.; Balibrea, J.; Barbagallo, M.; Bečvář, F.; Berthoumieux, E.; Billowes, J.; Bosnar, D.; Brown, A.; Caamaño, M.; Calviño, F.; Calviani, M.; Cano-Ott, D.; Cardella, R.; Casanovas, A.; Cerutti, F.; Chen, Y. H.; Colonna, N.; Cortés, G.; Cortés-Giraldo, M. A.; Cosentino, L.; Damone, L. A.; Diakaki, M.; Domingo-Pardo, C.; Dressler, R.; Dupont, E.; Durán, I.; Fernández-Domínguez, B.; Ferrari, A.; Ferreira, P.; Finocchiaro, P.; Göbel, K.; García, A. R.; Gawlik, A.; Gilardoni, S.; Glodariu, T.; Gonçalves, I. F.; González, E.; Griesmayer, E.; Guerrero, C.; Gunsing, F.; Harada, H.; Heinitz, S.; Heyse, J.; Jenkins, D. G.; Jericha, E.; Käppeler, F.; Kadi, Y.; Kalamara, A.; Kavrigin, P.; Kimura, A.; Kivel, N.; Kokkoris, M.; Krtička, M.; Kurtulgil, D.; Leal-Cidoncha, E.; Lederer, C.; Leeb, H.; Lerendegui-Marco, J.; Meo, S. Lo; Lonsdale, S. J.; Macina, D.; Marganiec, J.; Martínez, T.; Masi, A.; Massimi, C.; Mastinu, P.; Mastromarco, M.; Maugeri, E. A.; Mazzone, A.; Mendoza, E.; Mengoni, A.; Milazzo, P. M.; Mingrone, F.; Musumarra, A.; Negret, A.; Nolte, R.; Oprea, A.; Patronis, N.; Pavlik, A.; Perkowski, J.; Porras, I.; Praena, J.; Quesada, J. M.; Radeck, D.; Rauscher, T.; Reifarth, R.; Rubbia, C.; Ryan, J. A.; Sabaté-Gilarte, M.; Saxena, A.; Schillebeeckx, P.; Schumann, D.; Smith, A. G.; Sosnin, N. V.; Stamatopoulos, A.; Tagliente, G.; Tain, J. L.; Tarifeño-Saldivia, A.; Tassan-Got, L.; Tsinganis, A.; Valenta, S.; Vannini, G.; Variale, V.; Vaz, P.; Ventura, A.; Vlachoudis, V.; Vlastou, R.; Wallner, A.; Warren, S.; Woods, P. J.; Wright, T.; Žugec, P.

    2017-09-01

    The CERN n_TOF neutron beam facility is characterized by a very high instantaneous neutron flux, excellent TOF resolution at the 185 m long flight path (EAR-1), low intrinsic background and coverage of a wide range of neutron energies, from thermal to a few GeV. These characteristics provide a unique possibility to perform high-accuracy measurements of neutron-induced reaction cross-sections and angular distributions of interest for fundamental and applied Nuclear Physics. Since 2001, the n_TOF Collaboration has collected a wealth of high quality nuclear data relevant for nuclear astrophysics, nuclear reactor technology, nuclear medicine, etc. The overall efficiency of the experimental program and the range of possible measurements has been expanded with the construction of a second experimental area (EAR-2), located 20 m on the vertical of the n_TOF spallation target. This upgrade, which benefits from a neutron flux 30 times higher than in EAR-1, provides a substantial extension in measurement capabilities, opening the possibility to collect data on neutron cross-section of isotopes with short half-lives or available in very small amounts. This contribution will outline the main characteristics of the n_TOF facility, with special emphasis on the new experimental area. In particular, we will discuss the innovative features of the EAR-2 neutron beam that make possible to perform very challenging measurements on short-lived radioisotopes or sub-mg samples, out of reach up to now at other neutron facilities around the world. Finally, the future perspectives of the facility will be presented.

  20. The n_TOF facility: Neutron beams for challenging future measurements at CERN

    Directory of Open Access Journals (Sweden)

    Chiaveri E.

    2017-01-01

    Full Text Available The CERN n_TOF neutron beam facility is characterized by a very high instantaneous neutron flux, excellent TOF resolution at the 185 m long flight path (EAR-1, low intrinsic background and coverage of a wide range of neutron energies, from thermal to a few GeV. These characteristics provide a unique possibility to perform high-accuracy measurements of neutron-induced reaction cross-sections and angular distributions of interest for fundamental and applied Nuclear Physics. Since 2001, the n_TOF Collaboration has collected a wealth of high quality nuclear data relevant for nuclear astrophysics, nuclear reactor technology, nuclear medicine, etc. The overall efficiency of the experimental program and the range of possible measurements has been expanded with the construction of a second experimental area (EAR-2, located 20 m on the vertical of the n_TOF spallation target. This upgrade, which benefits from a neutron flux 30 times higher than in EAR-1, provides a substantial extension in measurement capabilities, opening the possibility to collect data on neutron cross-section of isotopes with short half-lives or available in very small amounts. This contribution will outline the main characteristics of the n_TOF facility, with special emphasis on the new experimental area. In particular, we will discuss the innovative features of the EAR-2 neutron beam that make possible to perform very challenging measurements on short-lived radioisotopes or sub-mg samples, out of reach up to now at other neutron facilities around the world. Finally, the future perspectives of the facility will be presented.

  1. An assessment of the secondary neutron dose in the passive scattering proton beam facility of the national cancer center

    Energy Technology Data Exchange (ETDEWEB)

    Han, Sang Eun [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of); Cho, Gyuseong [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Lee, Se Byeong [Proton Therapy Center, National Cancer Center, Goyang (Korea, Republic of)

    2017-06-15

    The purpose of this study is to assess the additional neutron effective dose during passive scattering proton therapy. Monte Carlo code (Monte Carlo N-Particle 6) simulation was conducted based on a precise modeling of the National Cancer Center's proton therapy facility. A three-dimensional neutron effective dose profile of the interior of the treatment room was acquired via a computer simulation of the 217.8-MeV proton beam. Measurements were taken with a 3He neutron detector to support the simulation results, which were lower than the simulation results by 16% on average. The secondary photon dose was about 0.8% of the neutron dose. The dominant neutron source was deduced based on flux calculation. The secondary neutron effective dose per proton absorbed dose ranged from 4.942 ± 0.031 mSv/Gy at the end of the field to 0.324 ± 0.006 mSv/Gy at 150 cm in axial distance.

  2. Impact of beam angle choice on pencil beam scanning breath-hold proton therapy for lung lesions

    DEFF Research Database (Denmark)

    Gorgisyan, Jenny; Perrin, Rosalind; Lomax, Antony J

    2017-01-01

    was highly patient specific, with a median of 3.3 mm (range: 0.0-41.1 mm). Slightly larger WEPL differences were located around the lateral or lateral anterior/posterior beam angles. Linear models revealed that changes in dose were associated to the changes in WEPL and the tumor baseline shift (p ....05). CONCLUSIONS: WEPL changes and tumor baseline shift can serve as reasonable surrogates for dosimetric uncertainty of the target coverage and are well-suited for routine evaluation of plan robustness. The two lateral beam angles are not recommended to use for PBS proton therapy of lung cancer patients treated...

  3. Potential clinical impact of laser-accelerated beams in cancer ion therapy

    Energy Technology Data Exchange (ETDEWEB)

    Obcemea, Ceferino

    2016-09-01

    In this article, I present three advantages of plasma-accelerated ion beams for cancer therapy. I discuss how: 1. low-emittance and well-collimated beams are advantageous in proximal normal tissue-sparing; 2. highly-peaked quasi-monoenergetic beams are ideal for fast energy selection and switching in Pencil Beam Scanning (PBS) as a treatment delivery; 3. high fluence and ultra-short pulse delivery produce collective excitations in the medium and enhance the stopping power. This in turn produces denser ionization track signatures (spurs, blobs, etc.) in target tumors, higher linear energy transfer, higher Bragg peak, and higher radiobiological effectiveness at the micro-level.

  4. Novel imaging and quality assurance techniques for ion beam therapy a Monte Carlo study

    CERN Document Server

    Rinaldi, I; Jäkel, O; Mairani, A; Parodi, K

    2010-01-01

    Ion beams exhibit a finite and well defined range in matter together with an “inverted” depth-dose profile, the so-called Bragg peak. These favourable physical properties may enable superior tumour-dose conformality for high precision radiation therapy. On the other hand, they introduce the issue of sensitivity to range uncertainties in ion beam therapy. Although these uncertainties are typically taken into account when planning the treatment, correct delivery of the intended ion beam range has to be assured to prevent undesired underdosage of the tumour or overdosage of critical structures outside the target volume. Therefore, it is necessary to define dedicated Quality Assurance procedures to enable in-vivo range verification before or during therapeutic irradiation. For these purposes, Monte Carlo transport codes are very useful tools to support the development of novel imaging modalities for ion beam therapy. In the present work, we present calculations performed with the FLUKA Monte Carlo code and pr...

  5. Development of a prompt gamma activation analysis facility using diffracted polychromatic neutron beam

    CERN Document Server

    Byun, S H; Choi, H D

    2002-01-01

    A prompt gamma activation analysis facility has recently been developed at Hanaro, the 24 MW research reactor in the Korea Atomic Energy Research Institute. Polychromatic thermal neutrons are extracted by setting pyrolytic graphite crystals at a Bragg angle of 45 deg. . The detection system comprises a large single n-type HPGe detector, signal electronics and a fast ADC. Neutron beam characterization was performed both theoretically and experimentally. The neutron flux was measured to be 7.9x10 sup 7 n/cm sup 2 s in a 1x1 cm sup 2 beam area at the sample position with a uniformity of 12%. The corresponding Cd-ratio for gold was found to be 266. The beam quality was compared with other representative thermal neutron prompt gamma activation analysis. The detection efficiency was calibrated up to 11 MeV using a set of radionuclides and the (n,gamma) reactions of N and Cl. Finally, the sensitivities and the detection limits were obtained for several elements.

  6. SU-E-J-99: Reconstruction of Cone Beam CT Image Using Volumetric Modulated Arc Therapy Exit Beams

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, K; Goddard, L; Savacool, M; Mynampati, D; Godoy Scripes, P; Tome' , W [Montefiore Medical Center, Bronx, NY (United States); Kuo, H; Basavatia, A; Hong, L; Yaparpalvi, R; Kalnicki, S [Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY (United States)

    2014-06-01

    Purpose: To test the possibility of obtaining an image of the treated volume during volumetric modulated arc therapy (VMAT) with exit beams. Method: Using a Varian Clinac 21EX and MVCT detector the following three sets of detector projection data were obtained for cone beam CT reconstruction with and without a Catphan 504 phantom. 1) 72 projection images from 20 × 16 cm{sup 2} open beam with 3 MUs, 2) 72 projection images from 20 × 16 cm{sup 2} MLC closed beam with 14 MUs. 3) 137 projection images from a test RapicArc QA plan. All projection images were obtained in ‘integrated image’ mode. We used OSCaR code to reconstruct the cone beam CT images. No attempts were made to reduce scatter or artifacts. Results: With projection set 1) we obtained a good quality MV CBCT image by optimizing the reconstruction parameters. Using projection set 2) we were not able to obtain a CBCT image of the phantom, which was determined to be due to the variation of interleaf leakage with gantry angle. From projection set 3), we were able to obtain a weak but meaningful signal in the image, especially in the target area where open beam signals were dominant. This finding suggests that one might be able to acquire CBCT images with rough body shape and some details inside the irradiated target area. Conclusion: Obtaining patient images using the VMAT exit beam is challenging but possible. We were able to determine sources of image degradation such as gantry angle dependent interleaf leakage and beams with a large scatter component. We are actively working on improving image quality.

  7. Proposal of cancer therapy system without rotating gantry

    International Nuclear Information System (INIS)

    Kodaira, Masanobu

    2002-01-01

    Beam therapy is one of useful methods for cancer therapy. Many results in National Institute of Radiological Sciences (NIRS) show many abilities of beam therapy for cancer therapy. In Japan, several beam therapy facilities are constructed or under construction. If its construction budget becomes to be smaller, beam therapy may be used as the general cancer therapy. But in the present beam therapy facilities, the budget of its construction is very large. One of the reasons of big budget is the construction of the big buildings equipped with thick shielding walls. Most of space of the facilities with thick shielding walls is devoted to the treatment equipments such as rotating gantries and beam transport lines. This proposal is that using oblique beam line and rotating treatment bed, multi-portal irradiation is realized without rotating gantry. At the same time, we designed adequate beam lines to minimize the total facilities. (author)

  8. Integrating supervision, control and data acquisition—The ITER Neutral Beam Test Facility experience

    Energy Technology Data Exchange (ETDEWEB)

    Luchetta, A., E-mail: adriano.luchetta@igi.cnr.it; Manduchi, G.; Taliercio, C.; Breda, M.; Capobianco, R.; Molon, F.; Moressa, M.; Simionato, P.; Zampiva, E.

    2016-11-15

    Highlights: • The paper describes the experience gained in the integration of different systems for the control and data acquisition system of the ITER Neutral Beam Test Facility. • It describes the way the different frameworks have been integrated. • It reports some lessons learnt during system integration. • It reports some authors’ considerations about the development the ITER CODAC. - Abstract: The ITER Neutral Beam (NBI) Test Facility, under construction in Padova, Italy consists in the ITER full scale ion source for the heating neutral beam injector, referred to as SPIDER, and the full size prototype injector, referred to as MITICA. The Control and Data Acquisition System (CODAS) for SPIDER has been developed and is going to be in operation in 2016. The system is composed of four main components: Supervision, Slow Control, Fast Control and Data Acquisition. These components interact with each other to carry out the system operation and, since they represent a common pattern in fusion experiments, software frameworks have been used for each (set of) component. In order to reuse as far as possible the architecture developed for SPIDER, it is important to clearly define the boundaries and the interfaces among the system components so that the implementation of any component can be replaced without affecting the overall architecture. This work reports the experience gained in the development of SPIDER components, highlighting the importance in the definition of generic interfaces among component, showing how the specific solutions have been adapted to such interfaces and suggesting possible approaches for the development of other ITER subsystems.

  9. SPIRAL2 at GANIL: Next Generation of ISOL Facility for Intense Secondary Radioactive Ion Beams

    Science.gov (United States)

    Gales, S.

    2010-03-01

    To pursue the investigation of a new territory of nuclei with extreme N/Z called terra incognita several projects, all aiming at the increase by several orders of magnitude of the Radioactive Ion Beams (RIB) intensities are now under discussions worldwide. As selected by the ESFRI committee, the next generation of ISOL facility in Europe is represented by the SPIRAL2 Project to be built at GANIL (Caen, France). SPIRAL 2 is based on a high power, CW, superconducting driver LINAC, delivering 5 mA of deuteron beams at 40MeV (200kW) directed on a C converter+ Uranium target and producing therefore up to 5ṡ1013fissions/s. The expected radioactive beams intensities for exotic species in the mass range from A=60 to A=140, of the order of 106 to 1010pps, will surpass by two orders of magnitude any existing facilities in the world. These unstable atoms will be available at energies between few keV/n to 15 MeV/n. The same driver will accelerate high intensity (100μA to 1 mA), heavy ions up to Ar at 14 MeV/A producing also proton rich exotic nuclei. In applied areas SPIRAL2 is considered as a powerful variable energy neutron source, a must to study the impact of nuclear fission and fusion on materials. Construction of the SPIRAL2 facility is shared by ten French laboratories and a network of international partners. Under the FP7 framework program of European Union called “Preparatory Phase” for the construction of new facilities, the SPIRAL2 project has been granted a budget of about 4Meuros to build up an international consortium around this new venture. Regarding the future physics program a call for Letter of intents has been launched in Oct 2006 and 8 large International collaborations has been built up around new instruments for SPIRAL2. The status of the construction of SPIRAL2 accelerator and technical R&D programs for physics instrumentation (detectors, spectrometers) in collaboration with EU and International partners will be presented.

  10. The construction of the Fiber-SiPM beam monitor system of the R484 and R582 experiments at the RIKEN-RAL muon facility

    International Nuclear Information System (INIS)

    Bonesini, M.; Bertoni, R.; Chignoli, F.; Mazza, R.; Cervi, T.; De Bari, A.; Menegolli, A.; Prata, M.C.; Rossella, M.; Tortora, L.; Carbone, R.; Mocchiutti, E.; Vacchi, A.; Vallazza, E.; Zampa, G.

    2017-01-01

    The scintillating fiber-SiPM beam monitor detectors, designed to deliver beam informations for the R484 and R582 experiments at the high intensity, low energy pulsed muon beam at the RIKEN-RAL facility, have been successfully constructed and operated. Details on their construction and first performances in beam are reported.

  11. Proton beam therapy for localized prostate cancer 101: basics, controversies, and facts.

    Science.gov (United States)

    Wisenbaugh, Eric S; Andrews, Paul E; Ferrigni, Robert G; Schild, Steven E; Keole, Sameer R; Wong, William W; Vora, Sujay A

    2014-01-01

    Proton beam therapy for prostate cancer has become a source of controversy in the urologic community, and the rapid dissemination and marketing of this technology has led to many patients inquiring about this therapy. Yet the complexity of the technology, the cost, and the conflicting messages in the literature have left many urologists ill equipped to counsel their patients regarding this option. This article reviews the basic science of the proton beam, examines the reasons for both the hype and the controversy surrounding this therapy, and, most importantly, examines the literature so that every urologist is able to comfortably discuss this option with inquiring patients.

  12. Treatment of cancer of the pancreas by intraoperative electron beam therapy: physical and biological aspects

    International Nuclear Information System (INIS)

    Bagne, F.R.; Dobelbower, R.R. Jr.; Milligan, A.J.; Bronn, D.G.

    1989-01-01

    Radiation therapy has had a significant and an expanded role in the management of cancer of the pancreas during the last decade. In particular, for locally advanced disease, radiation therapy has improved the median survival of patients to 1 year. Intraoperative electron beam therapy has been applied to unresectable and resectable pancreatic cancer in an attempt to enhance local control of disease and to improve patient survival. This paper presents a survey of the role of radiation therapy in treatment of cancer of the pancreas, provides information on the radiobiological aspects of this treatment modality and details the physical and dosimetric characteristics of intraoperative radiation therapy with electrons. Presented are the design specifics of an applicator system, central axis beam data, applicator parameters, dose distribution data, shielding, treatment planning and means of verification. Emphasis is placed on the collaboration and cooperation necessary for all members of the intraoperative radiation therapy team including surgeons, radiation therapists, medical physicists, anesthesiologists, technologists, and nurses.29 references

  13. Development of cancer therapy facility of Hanaro and medical research in BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Jun, Byung Jin; Kim, M. S.; Kim, M. J.; Park, S. J. [KAERI, Taejon (Korea, Republic of); Lee, C. H.; Kwack, H. S.; Kim, M. S. [Korea Inst. of Radiological and Medical Sciences, Seoul (Korea, Republic of); Kim, J. K.; Park, S. H.; Shin, C. H. [Hanyang Univ., Seoul (Korea, Republic of)

    2003-05-01

    In order to support the domestic research on the Boron Neutron Capture Therapy(BNCT) which is a promising treatment method for tumor in principle, a neutron irradiation facility and a Prompt Gamma Neutron Activation Analysis (PGNAA) equipment for the boron concentration measurement are developed and installed at Hanaro. Meanwhile basic research has been performed to develop BNCT medical technology using above Hanaro facilities when they are ready. The Hanaro BNCT facility gives almost pure thermal neutron beam, it can be applied to all level of BNCT research from the cell culture and animal study to clinical trials by focussed irradiation, and its use does not cause any interference with other utilization. It can also be used for other purposes such as standard thermal neutron field and a dynamic neutron radiography with excellent features. The PGNAA equipment will be used not only for the boron concentration measurement but also for the general multi-element simultaneous analyses. The medical research for BNCT covers basic research on dose evaluation, boron compound behaviour and new compound development. Technologies for neutron and gamma transport calculation and their measurement, and micro dosimetry are developed. While import of a dose planning program has been pushed, domestic development of the program has been tried. Imaging technologies for boron distribution using SPECT or PET are developed by labeling I-123 or F-18 to BPA. Data for the BPA accumulation into the brain tumor are produced by clinical trials of the technology. A general and versatile method for the synthesis of o-carborane clusters containing of their important biological activities as neurotransmitter, antipsychotic or anticancer is developed. We found three promising compounds of which accumulation into B-16 melanoma cell is about 10 times of BPA.

  14. Beamlines of the biomedical imaging and therapy facility at the Canadian light source - part 3

    Science.gov (United States)

    Wysokinski, Tomasz W.; Chapman, Dean; Adams, Gregg; Renier, Michel; Suortti, Pekka; Thomlinson, William

    2015-03-01

    The BioMedical Imaging and Therapy (BMIT) facility provides synchrotron-specific imaging and radiation therapy capabilities [1-4]. We describe here the Insertion Device (ID) beamline 05ID-2 with the beam terminated in the SOE-1 (Secondary Optical Enclosure) experimental hutch. This endstation is designed for imaging and therapy research primarily in animals ranging in size from mice to humans to horses, as well as tissue specimens including plants. Core research programs include human and animal reproduction, cancer imaging and therapy, spinal cord injury and repair, cardiovascular and lung imaging and disease, bone and cartilage growth and deterioration, mammography, developmental biology, gene expression research as well as the introduction of new imaging methods. The source for the ID beamline is a multi-pole superconducting 4.3 T wiggler [5]. The high field gives a critical energy over 20 keV. The high critical energy presents shielding challenges and great care must be taken to assess shielding requirements [6-9]. The optics in the POE-1 and POE-3 hutches [4,10] prepare a monochromatic beam that is 22 cm wide in the last experimental hutch SOE-1. The double crystal bent-Laue or Bragg monochromator, or the single-crystal K-edge subtraction (KES) monochromator provide an energy range appropriate for imaging studies in animals (20-100+ keV). SOE-1 (excluding the basement structure 4 m below the experimental floor) is 6 m wide, 5 m tall and 10 m long with a removable back wall to accommodate installation and removal of the Large Animal Positioning System (LAPS) capable of positioning and manipulating animals as large as a horse [11]. This end-station also includes a unique detector positioner with a vertical travel range of 4.9 m which is required for the KES imaging angle range of +12.3° to -7.3°. The detector positioner also includes moveable shielding integrated with the safety shutters. An update on the status of the other two end-stations at BMIT, described

  15. Beamlines of the biomedical imaging and therapy facility at the Canadian light source – part 3

    International Nuclear Information System (INIS)

    Wysokinski, Tomasz W.; Chapman, Dean; Adams, Gregg; Renier, Michel; Suortti, Pekka; Thomlinson, William

    2015-01-01

    The BioMedical Imaging and Therapy (BMIT) facility provides synchrotron-specific imaging and radiation therapy capabilities [1–4]. We describe here the Insertion Device (ID) beamline 05ID-2 with the beam terminated in the SOE-1 (Secondary Optical Enclosure) experimental hutch. This endstation is designed for imaging and therapy research primarily in animals ranging in size from mice to humans to horses, as well as tissue specimens including plants. Core research programs include human and animal reproduction, cancer imaging and therapy, spinal cord injury and repair, cardiovascular and lung imaging and disease, bone and cartilage growth and deterioration, mammography, developmental biology, gene expression research as well as the introduction of new imaging methods. The source for the ID beamline is a multi-pole superconducting 4.3 T wiggler [5]. The high field gives a critical energy over 20 keV. The high critical energy presents shielding challenges and great care must be taken to assess shielding requirements [6–9]. The optics in the POE-1 and POE-3 hutches [4,10] prepare a monochromatic beam that is 22 cm wide in the last experimental hutch SOE-1. The double crystal bent-Laue or Bragg monochromator, or the single-crystal K-edge subtraction (KES) monochromator provide an energy range appropriate for imaging studies in animals (20–100+ keV). SOE-1 (excluding the basement structure 4 m below the experimental floor) is 6 m wide, 5 m tall and 10 m long with a removable back wall to accommodate installation and removal of the Large Animal Positioning System (LAPS) capable of positioning and manipulating animals as large as a horse [11]. This end-station also includes a unique detector positioner with a vertical travel range of 4.9 m which is required for the KES imaging angle range of +12.3° to –7.3°. The detector positioner also includes moveable shielding integrated with the safety shutters. An update on the status of the other two end-stations at BMIT

  16. Beamlines of the biomedical imaging and therapy facility at the Canadian light source – part 3

    Energy Technology Data Exchange (ETDEWEB)

    Wysokinski, Tomasz W., E-mail: bmit@lightsource.ca [Canadian Light Source, Saskatoon, SK (Canada); Chapman, Dean [Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, SK (Canada); Adams, Gregg [Western College of Veterinary Medicine, Saskatoon, SK (Canada); Renier, Michel [European Synchrotron Radiation Facility, Grenoble (France); Suortti, Pekka [Department of Physics, University of Helsinki (Finland); Thomlinson, William [Department of Physics, University of Saskatchewan, Saskatoon, SK (Canada)

    2015-03-01

    The BioMedical Imaging and Therapy (BMIT) facility provides synchrotron-specific imaging and radiation therapy capabilities [1–4]. We describe here the Insertion Device (ID) beamline 05ID-2 with the beam terminated in the SOE-1 (Secondary Optical Enclosure) experimental hutch. This endstation is designed for imaging and therapy research primarily in animals ranging in size from mice to humans to horses, as well as tissue specimens including plants. Core research programs include human and animal reproduction, cancer imaging and therapy, spinal cord injury and repair, cardiovascular and lung imaging and disease, bone and cartilage growth and deterioration, mammography, developmental biology, gene expression research as well as the introduction of new imaging methods. The source for the ID beamline is a multi-pole superconducting 4.3 T wiggler [5]. The high field gives a critical energy over 20 keV. The high critical energy presents shielding challenges and great care must be taken to assess shielding requirements [6–9]. The optics in the POE-1 and POE-3 hutches [4,10] prepare a monochromatic beam that is 22 cm wide in the last experimental hutch SOE-1. The double crystal bent-Laue or Bragg monochromator, or the single-crystal K-edge subtraction (KES) monochromator provide an energy range appropriate for imaging studies in animals (20–100+ keV). SOE-1 (excluding the basement structure 4 m below the experimental floor) is 6 m wide, 5 m tall and 10 m long with a removable back wall to accommodate installation and removal of the Large Animal Positioning System (LAPS) capable of positioning and manipulating animals as large as a horse [11]. This end-station also includes a unique detector positioner with a vertical travel range of 4.9 m which is required for the KES imaging angle range of +12.3° to –7.3°. The detector positioner also includes moveable shielding integrated with the safety shutters. An update on the status of the other two end-stations at BMIT

  17. Biological shielding design and qualification of concreting process for construction of electron beam irradiation facility

    International Nuclear Information System (INIS)

    Petwal, V.C.; Kumar, P.; Suresh, N.; Parchani, G.; Dwivedi, J.; Thakurta, A.C.

    2011-01-01

    A technology demonstration facility for irradiation of food and agricultural products is being set-up by RRCAT at Indore. The facility design is based on linear electron accelerator with maximum beam power of 10 kW and can be operated either in electron mode at 10 MeV or photon modes at 5/7.5 MeV. Biological shielding has been designed in accordance with NCRP 51 to achieve dose rate at all accessible points outside the irradiation vault less than the permissible limit of 0.1 mR/hr. In addition to radiation attenuation property, concrete must have satisfactory mechanical properties to meet the structural requirements. There are number of site specific variables which affect the structural, thermal and radiological properties of concrete, leading to considerable difference in actual values and design values. Hence it is essential to establish a suitable site and environmental specific process to cast the concrete and qualify the process by experimental measurement. For process qualification we have cast concrete test blocks of different thicknesses up to 3.25 m and evaluated the radiological and mechanical properties by radiometry, ultrasonic and mechanical tests. In this paper we describe the biological shielding design of the facility and analyse the results of tests carried out for qualification of the process. (author)

  18. Target design optimization for an electron accelerator driven subcritical facility with circular and square beam profiles.

    Energy Technology Data Exchange (ETDEWEB)

    Gohar, M. Y. A; Sofu, T.; Zhong, Z.; Belch, H.; Naberezhnev, D.; Nuclear Engineering Division

    2008-10-30

    A subcritical facility driven by an electron accelerator is planned at the Kharkov Institute of Physics and Technology (KIPT) in Ukraine for medical isotope production, materials research, training, and education. The conceptual design of the facility is being pursued through collaborations between ANL and KIPT. As part of the design effort, the high-fidelity analyses of various target options are performed with formulations to reflect the realistic configuration and the three dimensional geometry of each design. This report summarizes the results of target design optimization studies for electron beams with two different beam profiles. The target design optimization is performed via the sequential neutronic, thermal-hydraulic, and structural analyses for a comprehensive assessment of each configuration. First, a target CAD model is developed with proper emphasis on manufacturability to provide a basis for separate but consistent models for subsequent neutronic, thermal-hydraulic, and structural analyses. The optimizations are pursued for maximizing the neutron yield, streamlining the flow field to avoid hotspots, and minimizing the thermal stresses to increase the durability. In addition to general geometric modifications, the inlet/outlet channel configurations, target plate partitioning schemes, flow manipulations and rates, electron beam diameter/width options, and cladding material choices are included in the design optimizations. The electron beam interactions with the target assembly and the neutronic response of the subcritical facility are evaluated using the MCNPX code. the results for the electron beam energy deposition, neutron generation, and utilization in the subcritical pile are then used to characterize the axisymmetric heat generation profiles in the target assembly with explicit simulations of the beam tube, the coolant, the clad, and the target materials. Both tungsten and uranium are considered as target materials. Neutron spectra from tungsten

  19. Target design optimization for an electron accelerator driven subcritical facility with circular and square beam profiles

    International Nuclear Information System (INIS)

    Gohar, M.Y.A; Sofu, T.; Zhong, Z.; Belch, H.; Naberezhnev, D.

    2008-01-01

    A subcritical facility driven by an electron accelerator is planned at the Kharkov Institute of Physics and Technology (KIPT) in Ukraine for medical isotope production, materials research, training, and education. The conceptual design of the facility is being pursued through collaborations between ANL and KIPT. As part of the design effort, the high-fidelity analyses of various target options are performed with formulations to reflect the realistic configuration and the three dimensional geometry of each design. This report summarizes the results of target design optimization studies for electron beams with two different beam profiles. The target design optimization is performed via the sequential neutronic, thermal-hydraulic, and structural analyses for a comprehensive assessment of each configuration. First, a target CAD model is developed with proper emphasis on manufacturability to provide a basis for separate but consistent models for subsequent neutronic, thermal-hydraulic, and structural analyses. The optimizations are pursued for maximizing the neutron yield, streamlining the flow field to avoid hotspots, and minimizing the thermal stresses to increase the durability. In addition to general geometric modifications, the inlet/outlet channel configurations, target plate partitioning schemes, flow manipulations and rates, electron beam diameter/width options, and cladding material choices are included in the design optimizations. The electron beam interactions with the target assembly and the neutronic response of the subcritical facility are evaluated using the MCNPX code. the results for the electron beam energy deposition, neutron generation, and utilization in the subcritical pile are then used to characterize the axisymmetric heat generation profiles in the target assembly with explicit simulations of the beam tube, the coolant, the clad, and the target materials. Both tungsten and uranium are considered as target materials. Neutron spectra from tungsten

  20. Ion Beam Facilities at the National Centre for Accelerator based Research using a 3 MV Pelletron Accelerator

    Science.gov (United States)

    Trivedi, T.; Patel, Shiv P.; Chandra, P.; Bajpai, P. K.

    A 3.0 MV (Pelletron 9 SDH 4, NEC, USA) low energy ion accelerator has been recently installed as the National Centre for Accelerator based Research (NCAR) at the Department of Pure & Applied Physics, Guru Ghasidas Vishwavidyalaya, Bilaspur, India. The facility is aimed to carried out interdisciplinary researches using ion beams with high current TORVIS (for H, He ions) and SNICS (for heavy ions) ion sources. The facility includes two dedicated beam lines, one for ion beam analysis (IBA) and other for ion implantation/ irradiation corresponding to switching magnet at +20 and -10 degree, respectively. Ions with 60 kV energy are injected into the accelerator tank where after stripping positively charged ions are accelerated up to 29 MeV for Au. The installed ion beam analysis techniques include RBS, PIXE, ERDA and channelling.

  1. Dosimetric properties of the fast neutron therapy beams at TAMVEC

    International Nuclear Information System (INIS)

    Almond, P.R.; Smith, A.R.; Smathers, J.R.; Otte, V.A.

    1975-01-01

    In October 1972, M.D. Anderson Hospital and Tumor Institute of the University of Texas System Cancer Center initiated a clinical trial of fast neutron radiotherapy using the cyclotron at Texas A and M University. Initially, the study used neutrons produced by bombarding beryllium with 16 MeV deuterons, but since March, 1973, neutrons from 50 MeV deuterons have been used. The dosimetric properties of the 30 MeV beams have also been measured for comparison with the neutron beams from D-T generators. The three beams are compared in terms of dose rate, skin sparing, depth dose and field flatness. Isodose curves for treatment planning were generated using the decrement line method and compared to curves measured by a computer controlled isodose plotter. This system was also used to measure the isodose curves for wedge fields. Dosimetry checks on various patients were made using silicon diodes as in vivo fast neutron dosimeters

  2. Total skin electron beam therapy in mycosis fungoides

    International Nuclear Information System (INIS)

    Terashima, Hiromi; Yamashita, Shigeru; Ishino, Yohichi; Suenaga, Yoshinori

    1988-01-01

    The studies using phantoms confirmed that the reduction of electron beam energy and minimization of X-ray contamination could be achieved when electron beam was interposed by an acrylic plate placed 20 cm anterior to a patient. Four patients of mycosis fungoides were treated with 8 MeV electron beam of a linear accelerator at UOEH Hospital from October 1981 to December 1986. Two of them were treated with this technique by placing 2 cm thick acrylic plate anterior to the patients and satisfactory results were obtained. Cutaneous lesions subsided remarkably with the dosage of 2000 cGy given in 2 months. Leucopenia due to bone marrow suppression was mild and the patients tolerated the treatment well. (author)

  3. Quantitative evaluation of potential irradiation geometries for carbon-ion beam grid therapy.

    Science.gov (United States)

    Tsubouchi, Toshiro; Henry, Thomas; Ureba, Ana; Valdman, Alexander; Bassler, Niels; Siegbahn, Albert

    2018-03-01

    Radiotherapy using grids containing cm-wide beam elements has been carried out sporadically for more than a century. During the past two decades, preclinical research on radiotherapy with grids containing small beam elements, 25 μm-0.7 mm wide, has been performed. Grid therapy with larger beam elements is technically easier to implement, but the normal tissue tolerance to the treatment is decreasing. In this work, a new approach in grid therapy, based on irradiations with grids containing narrow carbon-ion beam elements was evaluated dosimetrically. The aim formulated for the suggested treatment was to obtain a uniform target dose combined with well-defined grids in the irradiated normal tissue. The gain, obtained by crossfiring the carbon-ion beam grids over a simulated target volume, was quantitatively evaluated. The dose distributions produced by narrow rectangular carbon-ion beams in a water phantom were simulated with the PHITS Monte Carlo code. The beam-element height was set to 2.0 cm in the simulations, while the widths varied from 0.5 to 10.0 mm. A spread-out Bragg peak (SOBP) was then created for each beam element in the grid, to cover the target volume with dose in the depth direction. The dose distributions produced by the beam-grid irradiations were thereafter constructed by adding the dose profiles simulated for single beam elements. The variation of the valley-to-peak dose ratio (VPDR) with depth in water was thereafter evaluated. The separation of the beam elements inside the grids were determined for different irradiation geometries with a selection criterion. The simulated carbon-ion beams remained narrow down to the depths of the Bragg peaks. With the formulated selection criterion, a beam-element separation which was close to the beam-element width was found optimal for grids containing 3.0-mm-wide beam elements, while a separation which was considerably larger than the beam-element width was found advantageous for grids containing 0.5-mm

  4. Impact of Various Beam Parameters on Lateral Scattering in Proton and Carbon-ion Therapy.

    Science.gov (United States)

    Ebrahimi Loushab, M; Mowlavi, A A; Hadizadeh, M H; Izadi, R; Jia, S B

    2015-12-01

    In radiation therapy with ion beams, lateral distributions of absorbed dose in the tissue are important. Heavy ion therapy, such as carbon-ion therapy, is a novel technique of high-precision external radiotherapy which has advantages over proton therapy in terms of dose locality and biological effectiveness. In this study, we used Monte Carlo method-based Geant4 toolkit to simulate and calculate the effects of energy, shape and type of ion beams incident upon water on multiple scattering processes. Nuclear reactions have been taken into account in our calculation. A verification of this approach by comparing experimental data and Monte Carlo methods will be presented in an upcoming paper. Increasing particle energies, the width of the Bragg curve becomes larger but with increasing mass of particles, the width of the Bragg curve decreases. This is one of the advantages of carbon-ion therapy to treat with proton. The transverse scattering of dose distribution is increased with energy at the end of heavy ion beam range. It can also be seen that the amount of the dose scattering for carbon-ion beam is less than that of proton beam, up to about 160mm depth in water. The distortion of Bragg peak profiles, due to lateral scattering of carbon-ion, is less than proton. Although carbon-ions are primarily scattered less than protons, the corresponding dose distributions, especially the lateral dose, are not much less.

  5. Application of the Medipix2 technology to space radiation dosimetry and hadron therapy beam monitoring

    International Nuclear Information System (INIS)

    Pinsky, Lawrence; Stoffle, Nicholas; Jakubek, Jan; Pospisil, Stanislav; Leroy, Claude; Gutierrez, Andrea; Kitamura, Hisashi; Yasuda, Nakahiro; Uchihori, Yulio

    2011-01-01

    The Medipix2 Collaboration, based at CERN, has developed the TimePix version of the Medipix pixel readout chip, which has the ability to provide either an ADC or TDC capability separately in each of its 256x256 pixels. When coupled to a Si detector layer, the device is an excellent candidate for application as an active dosimeter for use in space radiation environments. In order to facilitate such a development, data have been taken with heavy ions at the HIMAC facility in Chiba, Japan. In particular, the problem of determining the resolution of such a detector system with respect to heavy ions of differing charges and energies, but with similar dE/dx values has been explored for several ions. The ultimate problem is to parse the information in the pixel 'footprint' images from the drift of the charge cloud produced in the detector layer. In addition, with the use of convertor materials, the detector can be used as a neutron detector, and it has been used both as a charged particle and neutron detector to evaluate the detailed properties of the radiation fields produced by hadron therapy beams. New versions of the basic chip design are ongoing.

  6. Proton therapy posterior beam approach with pencil beam scanning for esophageal cancer. Clinical outcome, dosimetry, and feasibility

    Energy Technology Data Exchange (ETDEWEB)

    Zeng, Yue-Can [Shengjing Hospital of China Medical University, Department of Medical Oncology, Cancer Center, Shenyang (China); University of Washington Medical Center, Department of Radiation Oncology, 1959 NE Pacific Street, Campus Box 356043, Seattle, WA (United States); Vyas, Shilpa; Apisarnthanarax, Smith; Zeng, Jing [University of Washington Medical Center, Department of Radiation Oncology, 1959 NE Pacific Street, Campus Box 356043, Seattle, WA (United States); Dang, Quang; Schultz, Lindsay [Seattle Cancer Care Alliance Proton Therapy Center, Seattle, WA (United States); Bowen, Stephen R. [University of Washington Medical Center, Department of Radiation Oncology, 1959 NE Pacific Street, Campus Box 356043, Seattle, WA (United States); University of Washington Medical Center, Department of Radiology, Seattle, WA (United States); Shankaran, Veena [University of Washington Medical Center, Department of Medical Oncology, Seattle, WA (United States); Farjah, Farhood [University of Washington Medical Center, Department of Surgery, Division of Cardiothoracic Surgery, Seattle, WA (United States); University of Washington Medical Center, Department of Surgery, Surgical Outcomes Research Center, Seattle, WA (United States); Oelschlager, Brant K. [University of Washington Medical Center, Department of Surgery, Seattle, WA (United States)

    2016-12-15

    The aim of this study is to present the dosimetry, feasibility, and preliminary clinical results of a novel pencil beam scanning (PBS) posterior beam technique of proton treatment for esophageal cancer in the setting of trimodality therapy. From February 2014 to June 2015, 13 patients with locally advanced esophageal cancer (T3-4N0-2M0; 11 adenocarcinoma, 2 squamous cell carcinoma) were treated with trimodality therapy (neoadjuvant chemoradiation followed by esophagectomy). Eight patients were treated with uniform scanning (US) and 5 patients were treated with a single posterior-anterior (PA) beam PBS technique with volumetric rescanning for motion mitigation. Comparison planning with PBS was performed using three plans: AP/PA beam arrangement; PA plus left posterior oblique (LPO) beams, and a single PA beam. Patient outcomes, including pathologic response and toxicity, were evaluated. All 13 patients completed chemoradiation to 50.4 Gy (relative biological effectiveness, RBE) and 12 patients underwent surgery. All 12 surgical patients had an R0 resection and pathologic complete response was seen in 25 %. Compared with AP/PA plans, PA plans have a lower mean heart (14.10 vs. 24.49 Gy, P < 0.01), mean stomach (22.95 vs. 31.33 Gy, P = 0.038), and mean liver dose (3.79 vs. 5.75 Gy, P = 0.004). Compared to the PA/LPO plan, the PA plan reduced the lung dose: mean lung dose (4.96 vs. 7.15 Gy, P = 0.020) and percentage volume of lung receiving 20 Gy (V{sub 20}; 10 vs. 17 %, P < 0.01). Proton therapy with a single PA beam PBS technique for preoperative treatment of esophageal cancer appears safe and feasible. (orig.) [German] Wir stellen die Vergleichsdosimetrie, Realisierbarkeit und die vorlaeufigen klinischen Ergebnisse einer neuen Pencil-Beam-Scanning(-PBS)/Posterior-Beam-Methode innerhalb der Protonentherapie fuer Speiseroehrenkrebs im Setting einer trimodalen Therapie vor. Von Februar 2014 bis Juni 2015 erhielten 13 Patienten mit lokal fortgeschrittenem

  7. HiRadMat at CERN/SPS - A dedicated facility providing high intensity beam pulses to material samples

    CERN Multimedia

    Charitonidis, N; Efthymiopoulos, I

    2014-01-01

    HiRadMat (High Radiation to Materials), constructed in 2011, is a facility at CERN designed to provide high‐intensity pulsed beams to an irradiation area where material samples as well as accelerator component assemblies (e.g. vacuum windows, high power beam targets, collimators…) can be tested. The facility uses a 440 GeV proton beam extracted from the CERN SPS with a pulse length of up to 7.2 us, and with a maximum pulse energy of 3.4 MJ (3xE13 proton/pulse). In addition to protons, ion beams with energy of 440 GeV/charge and total pulse energy of 21 kJ can be provided. The beam parameters can be tuned to match the needs of each experiment. HiRadMat is not an irradiation facility where large doses on equipment can be accumulated. It is rather a test area designed to perform single pulse experiments to evaluate the effect of high‐intensity pulsed beams on materials or accelerator component assemblies in a controlled environment. The fa‐ cility is designed for a maximum of 1E16 protons per year, dist...

  8. Real-time beam monitoring in scanned proton therapy

    Science.gov (United States)

    Klimpki, G.; Eichin, M.; Bula, C.; Rechsteiner, U.; Psoroulas, S.; Weber, D. C.; Lomax, A.; Meer, D.

    2018-05-01

    When treating cancerous tissues with protons beams, many centers make use of a step-and-shoot irradiation technique, in which the beam is steered to discrete grid points in the tumor volume. For safety reasons, the irradiation is supervised by an independent monitoring system validating cyclically that the correct amount of protons has been delivered to the correct position in the patient. Whenever unacceptable inaccuracies are detected, the irradiation can be interrupted to reinforce a high degree of radiation protection. At the Paul Scherrer Institute, we plan to irradiate tumors continuously. By giving up the idea of discrete grid points, we aim to be faster and more flexible in the irradiation. But the increase in speed and dynamics necessitates a highly responsive monitoring system to guarantee the same level of patient safety as for conventional step-and-shoot irradiations. Hence, we developed and implemented real-time monitoring of the proton beam current and position. As such, we read out diagnostic devices with 100 kHz and compare their signals against safety tolerances in an FPGA. In this paper, we report on necessary software and firmware enhancements of our control system and test their functionality based on three exemplary error scenarios. We demonstrate successful implementation of real-time beam monitoring and, consequently, compliance with international patient safety regulations.

  9. HVPTF-The high voltage laboratory for the ITER Neutral Beam test facility

    Energy Technology Data Exchange (ETDEWEB)

    De Lorenzi, A., E-mail: antonio.delorenzi@igi.cnr.it [Consorzio RFX-Associazione EURATOM-ENEA per la Fusione Corso Stati Uniti 4, 35127 Padova (Italy); Pilan, N.; Lotto, L.; Fincato, M. [Consorzio RFX-Associazione EURATOM-ENEA per la Fusione Corso Stati Uniti 4, 35127 Padova (Italy); Pesavento, G.; Gobbo, R. [DIE, Universita di Padova, Via Gradenigo 6A, I-35100 Padova (Italy)

    2011-10-15

    In the MITICA research program for the construction of the ITER Neutral Beam Injector prototype, a Laboratory for the investigation on high voltage holding in vacuum has been set up. This Laboratory - HVPTF: High Voltage Padova Test Facility - is presently capable of experiments up to 300 kV dc, and planned for the upgrade to 800 kV. The specific mission for this ancillary lab is the support to the electrostatic design and construction of the MITICA accelerator and the development and testing of HV components to be installed inside the MITICA accelerator during its operation. The paper describes the structure of the lab, characterized by a high degree of automation and reports the results of the commissioning at 300 kV and the first results of voltage holding between test electrodes.

  10. Results of a beam dump experiment at the CERN SPS neutrino facility

    Directory of Open Access Journals (Sweden)

    T. Hansl

    1978-03-01

    Full Text Available We report results from a beam dump experiment that has been performed at the CERN SPS neutrino facility using the CDHS neutrino counter detector. Limits on dimuon and trimuon production by new penetrating neutral particles are given. A new source of prompt electron and muon neutrinos has been observed giving (1.2±0.4× 10−7 νe or νμ per incident proton with neutrino angle smaller than 1.85 mrad and Eν > 20 GeV. If these prompt neutrinos are attributed to charmed meson pair production, the inclusive DD production cross section could be of the order of 30 ωb. If axions are existing their production rate relative to π0 mesons is found to be less than 0.5 × 10−8.

  11. Status of the 7 MeV/u, 217 MHz Injector Linac for the Heidelberg Cancer Therapy Facility

    CERN Document Server

    Schlitt, B; Hutter, G; Klos, F; Lu, Y; Minaev, S A; Mühle, C; Ratzinger, U; Schlitt, B; Tiede, R; Vinzenz, W; Will, C; Zurkan, O

    2004-01-01

    A clinical synchrotron facility for cancer therapy using energetic proton and ion beams (C, He and O) is under construction and will be installed at the Radiologische Universitätsklinik in Heidelberg, Germany, starting in 2005. The status of the ECR ion source systems, the beam line components of the low energy beam transport lines, the 400 keV/u RFQ and the 20 MV IH-cavity as well as the linac rf system will be reported. Two prototype magnets of the linac quadrupole magnets have been built at GSI and have been tested successfully. A test bench for the 1.4 MW, 217 MHz cavity amplifier built by industry has been installed at GSI including a 120 kW driver amplifier which will be used also for high power tests of the RFQ. A test bench for the RFQ using proton beams is presently being set up at the IAP. RF tuning of the 1:2 scaled IH-DTL model as well as Microwave Studio simulations of the model and the power cavity have been also performed at the IAP [1].

  12. Experiments on the collective interaction of a microsecond relativistic electron beam with a plasma in the GOL-3 facility

    International Nuclear Information System (INIS)

    Burdakov, A.V.; Voropaev, S.G.; Koidan, V.S.; Lebedev, S.V.; Mekler, K.I.; Nikiforov, A.A.; Postupaev, V.V.; Shcheglov, M.A.; Piffl, V.

    1996-01-01

    A considerable collisionless slowing of a beam in a plasma (a decrease in the mean electron energy by ∼25%) and transfer of a significant portion of the beam energy to the plasma are achieved as a result of the collective interaction of a microsecond relativistic electron beam with a plasma in the GOL-3 facility. A beam with a duration up to 5 μs and an energy up to 100 kJ is injected into a hydrogen plasma with a density ∼1015 cm-3 found in a 7-m solenoid with a field equal to 5.5 T. The specific energy content of the plasma remains longitudinally inhomogeneous during the heating period with a maximum near the point where the beam is injected. The parameters of the superthermal electrons born during the collective interaction are also determined. The features of the heating process and heat transfer in the plasma are discussed

  13. High Energy Tests of Advanced Materials for Beam Intercepting Devices at CERN HiRadMat Facility

    CERN Document Server

    Bertarelli, A; Berthome, E; Boccone, V; Carra, F; Cerutti, F; Dallocchio, A; Dos Santos, S; Francon, P; Gentini, L; Guinchard, M; Mariani, N; Masi, A; Moyret, P; Redaeelli, S; Peroni, L; Scapin, M

    2012-01-01

    Predicting by simulations the consequences of LHC particle beams hitting Collimators and other Beam Intercepting Devices (BID) is a fundamental issue for machine protection: this can be done by resorting to highly non-linear numerical tools (Hydrocodes). In order to produce accurate results, these codes require reliable material models that, at the extreme conditions generated by a beam impact, are either imprecise or non-existent. To validate relevant constitutive models or, when unavailable, derive new ones, a comprehensive experimental test foreseeing intense particle beam impacts on six different materials, either already used for present BID or under development for future applications, is being prepared at CERN HiRadMat facility. Tests will be run at medium and high intensity using the SPS proton beam (440 GeV). Material characterization will be carried out mostly in real time relying on embarked instrumentation (strain gauges, microphones, temperature and pressure sensors) and on remote acquisition dev...

  14. Using computer graphics to analyze the placement of neutral-beam injectors for the Mirror Fusion Test Facility

    International Nuclear Information System (INIS)

    Horvath, J.A.

    1977-01-01

    To optimize the neutral-beam current incident on the fusion plasma and limit the heat load on exposed surfaces of the Mirror Fusion Test Facility magnet coils, impingement of the neutral beams on the magnet structure must be minimized. Also, placement of the neutral-beam injectors must comply with specifications for neutral-current heating of the plasma and should allow maximum flexibility to accommodate alternative beam aiming patterns without significant hardware replacement or experiment down-time. Injector placements and aimings are analyzed by means of the Structural Analysis Movie Post Processor (SAMPP), a general-purpose graphics code for the display of three-dimensional finite-element models. SAMPP is used to visually assemble, disassemble, or cut away sections of the complex three-dimensional apparatus, which is represented by an assemblage of 8-node solid finite elements. The resulting picture is used to detect and quantify interactions between the structure and the neutral-particle beams

  15. ISABELLE: a proton-proton colliding beam facility. [Proposal for the construction of ISABELLE

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-04-01

    A proposal is presented for the construction of an Intersecting Storage Accelerator, ISABELLE, to be located at Brookhaven National Laboratory. At this major research facility, colliding beams of protons will be produced and studied by particle physicists. This proposal combines the interests of these particle physicists in exploring a new energy regime with the challenge of building a new research instrument. The proposal results from several years of considering such devices in parallel with extensive developmental work. The proposal is divided into several major parts. Following an introduction is an overall summary of the proposal covering its highlights. Part II contains a thorough discussion of the physics objectives that can be addressed by the storage ring. It begins with an explanation of current theoretical concepts that occupy the curiosity of high energy physicists. Then follows a brief discussion of possible experiments that might be assembled at the interaction regions to test these concepts. The third part of the proposal goes into the details of the design of the intersecting storage accelerators. It begins with a description of the entire facility and the design of the magnet ring structure. The processes of proton beam accumulation and acceleration are thoroughly described. The discussion then turns to the design of the components and subsystems for the accelerator. The accelerator elements are described followed by a description of the physical plant. The cost estimate and time scales are displayed in Part IV. Here the estimate has been based on the experience gained from working with the prototype units at the laboratory. The appendices are an important part of the proposal. The parameter list for the 200 x 200 GeV ISABELLE is carefully documented. An example of a possible research program can be found in an appendix. The performance of prototype units is documented in one of the appendices.

  16. Progress in control and data acquisition for the ITER neutral beam test facility

    Energy Technology Data Exchange (ETDEWEB)

    Luchetta, Adriano, E-mail: adriano.luchetta@igi.cnr.it [Consorzio RFX, Euratom-ENEA Association, Padova (Italy); Manduchi, Gabriele; Taliercio, Cesare; Soppelsa, Anton [Consorzio RFX, Euratom-ENEA Association, Padova (Italy); Paolucci, Francesco; Sartori, Filippo [Fusion for Energy, Barcelona (Spain); Barbato, Paolo; Capobianco, Roberto; Breda, Mauro; Molon, Federico; Moressa, Modesto; Polato, Sandro; Simionato, Paola; Zampiva, Enrico [Consorzio RFX, Euratom-ENEA Association, Padova (Italy)

    2013-10-15

    Highlights: ► An ion source experiment, referred to as SPIDER, is under construction in the ITER neutral beam test facility. ► The progress in designing and testing the SPIDER control and data acquisition system is reported. ► An original approach is proposed in using ITER CODAC and non-ITER CODAC technology. -- Abstract: SPIDER, the ion source test bed in the ITER neutral beam test facility, is under construction and its operation is expected to start in 2014. Control and data acquisition for SPIDER are undergoing final design. SPIDER CODAS, as the control and data acquisition system is referred to, is requested to manage 25 plant units, to acquire 1000 analogue signals with sampling rates ranging from a few S/s to 10 MS/s, to acquire images with up to 100 frames per second, to operate with long pulses lasting up to 1 h, and to sustain 200 MB/s data throughput into the data archive with an annual data storage amount of up to 50 TB. SPIDER CODAS software architecture integrates three open-source software frameworks each addressing specific system requirements. Slow control exploits the synergy among EPICS and Siemens S7 programmable controllers. Data handling is by MDSplus a data-centric framework that is geared towards the collection and organization of scientific data. Diagnostics based on imaging drive the design of data throughput and archive size. Fast control is implemented by using MARTe, a data-driven, object-oriented, real-time environment. The paper will describe in detail the progress of the system hardware and software architecture and will show how the software frameworks interact to provide the functions requested by SPIDER CODAS. The paper will focus on how the performance requirements can be met with the described SPIDER CODAS architecture, describing the progress achieved by carrying out prototyping activities.

  17. System and method for dose verification and gamma ray imaging in ion beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Mihailescu, Lucian

    2017-12-26

    This disclosure provides systems, methods, and apparatus related to ion beam therapy. In one aspect, a system includes a position sensitive detector and a collimator. The position sensitive detector configured to detect gamma rays generated by an ion beam interacting with a target. The collimator is positioned between the target and the position sensitive detector. The collimator includes a plurality of knife-edge slits, with a first knife-edge slit intersecting with a second knife-edge slit.

  18. Experience with high-energy electron beam therapy at the University of Chicago

    International Nuclear Information System (INIS)

    Griem, M.L.; Kuchnir, F.T.; Lanzl, L.H.; Skaggs, L.S.; Sutton, H.G.; Tokars, R.

    1979-01-01

    Current utilization of the linear accelerator as well as 5-year cumulative experience in radiotherapy is presented. Cutaneous lymphomas and mammary gland carcinomas were the prime experience region; however, cancers at other locations were treated with mixed-beam therapy; employing fast neutrons and photon beams. The technique appears promising for abdominal tumors and deep-seated malignancies. Carcinoma of the pancreas responds favorably to this technique

  19. Medical cyclotron facilities

    International Nuclear Information System (INIS)

    1984-09-01

    This report examines the separate proposals from the Austin Hospital and the Australian Atomic Energy Commission for a medical cyclotron facility. The proponents have argued that a cyclotron facility would benefit Australia in areas of patient care, availability and export of radioisotopes, and medical research. Positron emission tomography (PET) and neutron beam therapy are also examined

  20. T2-weighted endorectal magnetic resonance imaging of prostate cancer after external beam radiation therapy

    International Nuclear Information System (INIS)

    Westphalen, Antonio C.; Kurhanewicz, John; Cunha, Rui M.G.; Hsu, I-Chow; Kornak, John; Zhao, Shoujun; Coakley, Fergus V.

    2009-01-01

    Purpose: To retrospectively determine the accuracy of T2-weighted endorectal MR imaging in the detection of prostate cancer after external beam radiation therapy and to investigate the relationship between imaging accuracy and time since therapy. Materials and Methods: Institutional review board approval was obtained and the study was HIPPA compliant. We identified 59 patients who underwent 1.5 Tesla endorectal MR imaging of the prostate between 1999 and 2006 after definitive external beam radiation therapy for biopsy-proven prostate cancer. Two readers recorded the presence or absence of tumor on T2-weighted images. Logistic regression and Fisher's exact tests for 2x2 tables were used to determine the accuracy of imaging and investigate if accuracy differed between those imaged within 3 years of therapy (n = 25) and those imaged more than 3 years after therapy (n = 34). Transrectal biopsy was used as the standard of reference for the presence or absence of recurrent cancer. Results: Thirty-four of 59 patients (58%) had recurrent prostate cancer detected on biopsy. The overall accuracy of T2-weighted MR imaging in the detection cancer after external beam radiation therapy was 63% (37/59) for reader 1 and 71% for reader 2 (42/59). For both readers, logistic regression showed no difference in accuracy between those imaged within 3 years of therapy and those imaged more than 3 years after therapy (p = 0.86 for reader 1 and 0.44 for reader 2). Conclusion: T2-weighted endorectal MR imaging has low accuracy in the detection of prostate cancer after external beam radiation therapy, irrespective of the time since therapy. (author)

  1. T2-weighted endorectal magnetic resonance imaging of prostate cancer after external beam radiation therapy

    Directory of Open Access Journals (Sweden)

    Antonio C. Westphalen

    2009-04-01

    Full Text Available PURPOSE: To retrospectively determine the accuracy of T2-weighted endorectal MR imaging in the detection of prostate cancer after external beam radiation therapy and to investigate the relationship between imaging accuracy and time since therapy. MATERIAL AND METHODS: Institutional review board approval was obtained and the study was HIPPA compliant. We identified 59 patients who underwent 1.5 Tesla endorectal MR imaging of the prostate between 1999 and 2006 after definitive external beam radiation therapy for biopsy-proven prostate cancer. Two readers recorded the presence or absence of tumor on T2-weighted images. Logistic regression and Fisher’s exact tests for 2x2 tables were used to determine the accuracy of imaging and investigate if accuracy differed between those imaged within 3 years of therapy (n = 25 and those imaged more than 3 years after therapy (n = 34. Transrectal biopsy was used as the standard of reference for the presence or absence of recurrent cancer. RESULTS: Thirty-four of 59 patients (58% had recurrent prostate cancer detected on biopsy. The overall accuracy of T2-weighted MR imaging in the detection cancer after external beam radiation therapy was 63% (37/59 for reader 1 and 71% for reader 2 (42/59. For both readers, logistic regression showed no difference in accuracy between those imaged within 3 years of therapy and those imaged more than 3 years after therapy (p = 0.86 for reader 1 and 0.44 for reader 2. CONCLUSION: T2-weighted endorectal MR imaging has low accuracy in the detection of prostate cancer after external beam radiation therapy, irrespective of the time since therapy.

  2. T2-weighted endorectal magnetic resonance imaging of prostate cancer after external beam radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Westphalen, Antonio C.; Kurhanewicz, John; Cunha, Rui M.G.; Hsu, I-Chow; Kornak, John; Zhao, Shoujun; Coakley, Fergus V. [University of California San Francisco, San Francisco, CA (United States). Dept. of Radiology. Abdominal Imaging Section], e-mail: antonio.westphalen@radiology.ucsf.edu

    2009-01-15

    Purpose: To retrospectively determine the accuracy of T2-weighted endorectal MR imaging in the detection of prostate cancer after external beam radiation therapy and to investigate the relationship between imaging accuracy and time since therapy. Materials and Methods: Institutional review board approval was obtained and the study was HIPPA compliant. We identified 59 patients who underwent 1.5 Tesla endorectal MR imaging of the prostate between 1999 and 2006 after definitive external beam radiation therapy for biopsy-proven prostate cancer. Two readers recorded the presence or absence of tumor on T2-weighted images. Logistic regression and Fisher's exact tests for 2x2 tables were used to determine the accuracy of imaging and investigate if accuracy differed between those imaged within 3 years of therapy (n = 25) and those imaged more than 3 years after therapy (n = 34). Transrectal biopsy was used as the standard of reference for the presence or absence of recurrent cancer. Results: Thirty-four of 59 patients (58%) had recurrent prostate cancer detected on biopsy. The overall accuracy of T2-weighted MR imaging in the detection cancer after external beam radiation therapy was 63% (37/59) for reader 1 and 71% for reader 2 (42/59). For both readers, logistic regression showed no difference in accuracy between those imaged within 3 years of therapy and those imaged more than 3 years after therapy (p = 0.86 for reader 1 and 0.44 for reader 2). Conclusion: T2-weighted endorectal MR imaging has low accuracy in the detection of prostate cancer after external beam radiation therapy, irrespective of the time since therapy. (author)

  3. The external beam facility used to characterize corrosion products in metallic statuettes

    International Nuclear Information System (INIS)

    Rizzutto, M.A.; Tabacniks, M.H.; Added, N.; Barbosa, M.D.L.; Curado, J.F.; Santos, W.A.; Lima, S.C.; Melo, H.G.; Neiva, A.C.

    2005-01-01

    To open new possibilities in nuclear applied physics research, mainly for the analysis of art objects in air, an external beam facility was installed at LAMFI (Laboratorio de Analise de Materiais por Feixes Ionicos) of University of Sao Paulo. PIXE measurements were made using an XR-100CR (Si-PIN) X-ray detector pointed to the sample mounted after an approximate 11 mm air path, hence with effective beam energy of 0.9 MeV. This setup was used to characterize the corrosion products of two ethnological metallic statuettes from the African collection of the Museum of Archaeology and Etnology. PIXE analysis of the corrosion free base of one statuette showed that Cu and Zn are the main components of the alloy, while Pb is present in smaller amount. The analysis of some corrosion products showed a Zn:Cu relationship higher than that of the base, evidencing selective corrosion. The main components of the other statuette were Cu and Pb, while S and Zn were found in smaller amounts

  4. The external beam facility used to characterize corrosion products in metallic statuettes

    Science.gov (United States)

    Rizzutto, M. A.; Tabacniks, M. H.; Added, N.; Barbosa, M. D. L.; Curado, J. F.; Santos, W. A.; Lima, S. C.; Melo, H. G.; Neiva, A. C.

    2005-10-01

    To open new possibilities in nuclear applied physics research, mainly for the analysis of art objects in air, an external beam facility was installed at LAMFI (Laboratório de Análise de Materiais por Feixes Iônicos) of University of São Paulo. PIXE measurements were made using an XR-100CR (Si-PIN) X-ray detector pointed to the sample mounted after an approximate 11 mm air path, hence with effective beam energy of 0.9 MeV. This setup was used to characterize the corrosion products of two ethnological metallic statuettes from the African collection of the Museum of Archaeology and Etnology. PIXE analysis of the corrosion free base of one statuette showed that Cu and Zn are the main components of the alloy, while Pb is present in smaller amount. The analysis of some corrosion products showed a Zn:Cu relationship higher than that of the base, evidencing selective corrosion. The main components of the other statuette were Cu and Pb, while S and Zn were found in smaller amounts.

  5. Design of vacuum vessel for Indian Test Facility (INTF) for 100 keV neutral beams

    International Nuclear Information System (INIS)

    Joshi, Jaydeep; Yadav, Ashish; Gangadharan, Roopesh; Prasad, Rambilas; Ulahannan, Shino; Rotti, Chandramouli; Bandyopadhyay, Mainak; Chakraborty, Arun

    2015-01-01

    Highlights: • Thickness calculation and optimization for the main shell, ducts, Dishends and top lid on the main shell. • Nozzle and flange design for the port openings. • Support structure design for the main shell and ducts. • FEA validation of the INTF vessel for operational, seismic and lifting condition. - Abstract: The Indian Test Facility (INTF) vacuum vessel is designed to install a full-scale test set-up of Diagnostic Neutral Beam (DNB) [1] for the qualification of beam parameters and the behavior of beam-line components prior to installation and operation in ITER. Vacuum vessel is designed in cylindrical shape having length of ∼9 m with diameter of ∼4.5 m and has a detachable top-lid for mounting as well as removal of internal components during installation and maintenance phases. The Vessel has hemispherical dish-ends with large openings for high-voltage bushing on one side and duct on another side. Vessel is provided with openings for hydraulic, cryo, gas-feed and diagnostics. Vessel duct is composed of three segments with length ranges from 3 m to 5 m with diameter of ∼1.5 m and one vessel at the end to house the second calorimeter. The objective of this paper is to present the design and analysis of vacuum vessel, with respect to its functional and operational requirements. The design calculations are done as per ASME-BPVC SectionVIII-Div.1 and subsequently Finite Element Analysis (FEM) method has been adopted to verify the design.

  6. Design of vacuum vessel for Indian Test Facility (INTF) for 100 keV neutral beams

    Energy Technology Data Exchange (ETDEWEB)

    Joshi, Jaydeep, E-mail: Jaydeep.joshi@iter-india.org [ITER-India, Institute for Plasma Research, A29, GIDC Electronics Estate, Gandhinagar 382016, Gujarat (India); Yadav, Ashish; Gangadharan, Roopesh [ITER-India, Institute for Plasma Research, A29, GIDC Electronics Estate, Gandhinagar 382016, Gujarat (India); Prasad, Rambilas [Madan Mohan Malaviya University of Technology, Gorakhpur, Uttar Pradesh 273001 (India); Ulahannan, Shino [Airframe Aerodesigns Pvt. Ltd., HAL Airport Exit Road, Old Airport Road, Bengaluru 17 (India); Rotti, Chandramouli; Bandyopadhyay, Mainak; Chakraborty, Arun [ITER-India, Institute for Plasma Research, A29, GIDC Electronics Estate, Gandhinagar 382016, Gujarat (India)

    2015-10-15

    Highlights: • Thickness calculation and optimization for the main shell, ducts, Dishends and top lid on the main shell. • Nozzle and flange design for the port openings. • Support structure design for the main shell and ducts. • FEA validation of the INTF vessel for operational, seismic and lifting condition. - Abstract: The Indian Test Facility (INTF) vacuum vessel is designed to install a full-scale test set-up of Diagnostic Neutral Beam (DNB) [1] for the qualification of beam parameters and the behavior of beam-line components prior to installation and operation in ITER. Vacuum vessel is designed in cylindrical shape having length of ∼9 m with diameter of ∼4.5 m and has a detachable top-lid for mounting as well as removal of internal components during installation and maintenance phases. The Vessel has hemispherical dish-ends with large openings for high-voltage bushing on one side and duct on another side. Vessel is provided with openings for hydraulic, cryo, gas-feed and diagnostics. Vessel duct is composed of three segments with length ranges from 3 m to 5 m with diameter of ∼1.5 m and one vessel at the end to house the second calorimeter. The objective of this paper is to present the design and analysis of vacuum vessel, with respect to its functional and operational requirements. The design calculations are done as per ASME-BPVC SectionVIII-Div.1 and subsequently Finite Element Analysis (FEM) method has been adopted to verify the design.

  7. A 4 MV flattening filter-free beam: commissioning and application to conformal therapy and volumetric modulated arc therapy

    International Nuclear Information System (INIS)

    Stevens, S W; Rosser, K E; Bedford, J L

    2011-01-01

    Recent studies have indicated that radiotherapy treatments undertaken on a flattening filter-free (FFF) linear accelerator have a number of advantages over treatments undertaken on a conventional linear accelerator. In addition, 4 MV photon beams may give improved isodose coverage for some treatment volumes at air/tissue interfaces, compared to when utilizing the clinical standard of 6 MV photons. In order to investigate these benefits, FFF beams were established on an Elekta Beam Modulator linear accelerator for 4 MV photons. Commissioning beam data were obtained for open and wedged fields. The measured data were then imported into a treatment planning system and a beam model was commissioned. The beam model was optimized to improve dose calculations at shallow, clinically relevant depths. Following verification, the beam model was utilized in a treatment planning study, including volumetric modulated arc therapy, for a selection of lung, breast/chest wall and larynx patients. Increased dose rates of around 800 MU min -1 were recorded for open fields (relative to 320 MU min -1 for filtered open fields) and reduced head scatter was inferred from output factor measurements. Good agreement between planned and delivered dose was observed in verification of treatment plans. The planning study indicated that with a FFF beam, equivalent (and in some cases improved) isodose profiles could be achieved for small lung and larynx treatment volumes relative to 4 MV filtered treatments. Furthermore, FFF treatments with wedges could be replicated using open fields together with an 'effective wedge' technique and isocentre shift. Clinical feasibility of a FFF beam was therefore demonstrated, with beam modelling, treatment planning and verification being successfully accomplished.

  8. Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions

    Energy Technology Data Exchange (ETDEWEB)

    Berman, Abigail T., E-mail: abigail.berman@uphs.upenn.edu [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104 (United States); James, Sara St.; Rengan, Ramesh [Department of Radiation Oncology, University of Washington Medical Center, Seattle, WA 98195 (United States)

    2015-07-02

    Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT), through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve the therapeutic ratio. Herein, we provide a primer on the physics of proton beam therapy for lung cancer, present the existing data in early-stage and locally-advanced non-small cell lung cancer (NSCLC), as well as in special situations such as re-irradiation and post-operative radiation therapy. We then present the technical challenges, such as anatomic changes and motion management, and future directions for PBT in lung cancer, including pencil beam scanning.

  9. Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions

    Directory of Open Access Journals (Sweden)

    Abigail T. Berman

    2015-07-01

    Full Text Available Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT, through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve the therapeutic ratio. Herein, we provide a primer on the physics of proton beam therapy for lung cancer, present the existing data in early-stage and locally-advanced non-small cell lung cancer (NSCLC, as well as in special situations such as re-irradiation and post-operative radiation therapy. We then present the technical challenges, such as anatomic changes and motion management, and future directions for PBT in lung cancer, including pencil beam scanning.

  10. The potentials of proton beam radiation therapy in malignant lymphoma, thymoma and sarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Bjoerk-Eriksson, Thomas [Sahlgrenska Univ. Hospital, Goeteborg (Sweden). Dept. of Oncology; Bjelkengren, Goeran [Univ. Hospital, Malmoe (Sweden). Dept. of Oncology; Glimelius, Bengt [Karolinska Inst., Stockholm (Sweden). Dept. of Oncology and Pathology; Akademiska sjukhuset, Uppsala (Sweden). Dept. of Oncology, Radiology and Clinical Immunology

    2005-12-01

    A group of Swedish oncologists and hospital physicists have estimated the number of patients in Sweden suitable for proton beam therapy. The estimations have been based on current statistics of tumour incidence, number of patients potentially eligible for radiation treatment, scientific support from clinical trials and model dose planning studies and knowledge of the dose-response relations of different tumours and normal tissues. Besides sarcomas of the base of skull, which are classical sites for proton beam therapy, it is estimated that about 40 patients yearly in Sweden with sarcomas at other sites are candidates for proton beam therapy. About 20 patients each with malignant lymphomas, chiefly in the mediastinum, and thymomas are also candidates to decrease doses to surrounding heart and lungs.

  11. Shaping and monitoring of the mini-beam structures for the spatially fractionated hadron radiation therapy

    Directory of Open Access Journals (Sweden)

    I. Momot

    2016-06-01

    Full Text Available Design of collimators and their effectiveness for the purposes of the fractionated mini-beam hadron radiation therapy were evaluated by Monte Carlo simulations. The calculations have been performed for proton, carbon and oxygen ion beams at the energies relevant for medical applications. Micropixel metal and hybrid detectors were tested for measuring charged particles intensity distribution in multi-beam structures shaped by slit or matrix collimators exploring low energy proton beam at the Tandem generator (INR NASU, Kyiv. The results obtained illustrate reliable performance of the designed collimators as well as hybrid and metal microdetectors for measuring and imaging in real time the proton intensity distribution over mini-beam structures.

  12. Neutron H*(10) inside a proton therapy facility: comparison between Monte Carlo simulations and WENDI-2 measurements

    International Nuclear Information System (INIS)

    De Smet, V.; Stichelbaut, F.; Mathot, G.; Vanaudenhove, T.; De Lentdecker, G.; Dubus, A.; Pauly, N.; Gerardy, I.

    2014-01-01

    Inside an IBA proton therapy centre, secondary neutrons are produced due to nuclear interactions of the proton beam with matter mainly inside the cyclotron, the beam line, the treatment nozzle and the patient. Accurate measurements of the neutron ambient dose equivalent H*(10) in such a facility require the use of a detector that has a good sensitivity for neutrons ranging from thermal energies up to 230 MeV, such as for instance the WENDI-2 detector. WENDI-2 measurements have been performed at the Westdeutsches Protonentherapiezentrum Essen, at several positions around the cyclotron room and around a gantry treatment room operated in two different beam delivery modes: Pencil Beam Scanning and Double Scattering. These measurements are compared with Monte Carlo simulation results for the neutron H*(10) obtained with MCNPX 2.5.0 and GEANT4 9.6. In proton therapy, proton beams with energies up to typically 230 MeV are used to treat cancerous tumours very efficiently while sparing surrounding healthy tissues as much as possible. Due to nuclear interactions of the proton beams with matter, mainly inside the cyclotron, the beam line, the treatment nozzle and the patient, secondary neutrons with energies up to 230 MeV are unfortunately produced, as well as photons up to ∼10 MeV. Behind the thick concrete shielding walls which are necessary to attenuate the stray radiation fields, the total ambient dose equivalent H*(10) is very large due to the neutron component. In shielding studies for proton therapy facilities, the neutron H*(10) component is often evaluated using the Monte Carlo codes MCNPX(5), FLUKA(6) or PHITS(7). Recent benchmark simulations performed with GEANT4 have shown that this code would also be a suitable tool for the shielding studies of proton therapy centres. The experimental validation of such shielding studies requires the use of a detector with a good sensitivity for neutrons ranging from thermal energies up to 230 MeV, such as for example the

  13. Improved Beam Angle Arrangement in Intensity Modulated Proton Therapy Treatment Planning for Localized Prostate Cancer

    International Nuclear Information System (INIS)

    Cao, Wenhua; Lim, Gino J.; Li, Yupeng; Zhu, X. Ronald; Zhang, Xiaodong

    2015-01-01

    Purpose: This study investigates potential gains of an improved beam angle arrangement compared to a conventional fixed gantry setup in intensity modulated proton therapy (IMPT) treatment for localized prostate cancer patients based on a proof of principle study. Materials and Methods: Three patients with localized prostate cancer retrospectively selected from our institution were studied. For each patient, IMPT plans were designed using two, three and four beam angles, respectively, obtained from a beam angle optimization algorithm. Those plans were then compared with ones using two lateral parallel-opposed beams according to the conventional planning protocol for localized prostate cancer adopted at our institution. Results: IMPT plans with two optimized angles achieved significant improvements in rectum sparing and moderate improvements in bladder sparing against those with two lateral angles. Plans with three optimized angles further improved rectum sparing significantly over those two-angle plans, whereas four-angle plans found no advantage over three-angle plans. A possible three-beam class solution for localized prostate patients was suggested and demonstrated with preserved dosimetric benefits because individually optimized three-angle solutions were found sharing a very similar pattern. Conclusions: This study has demonstrated the potential of using an improved beam angle arrangement to better exploit the theoretical dosimetric benefits of proton therapy and provided insights of selecting quality beam angles for localized prostate cancer treatment

  14. Application of the Medipix2 technology to space radiation dosimetry and hadron therapy beam monitoring

    International Nuclear Information System (INIS)

    Pinsky, Lawrence; Stoffle, Nicholas; Empl, Anton; Jakubek, Jan; Pospisil, Stanislav; Leroy, Claude; Kitamura, Hisashi; Yasuda, Nakahiro; Uchihori, Yukio

    2011-01-01

    The Medipix2 Collaboration, based at CERN, has developed the TimePix version of the Medipix pixel readout chip, which has the ability to provide either an ADC or TDC capability separately in each of its 256 × 256 pixels. When coupled to a Si detector layer, the device is an excellent candidate for application as an active dosimeter for use in Space Radiation Environments. In order to facilitate such a development, data have been taken with Heavy Ions at the HIMAC facility in Chiba, Japan. In particular, the problem of determining the resolution of such a detector system with respect to heavy ions of differing charges and energies, but with similar dE/dx values has been explored for several ions. The ultimate problem is to parse the information in the pixel “footprint” images from the drift of the charge-cloud produced in the detector layer. In addition, with the use of convertor materials, the detector can be used as a neutron detector, and it has been used both as a charged particle and neutron detector to evaluate the detailed properties of the radiation fields produced by hadron therapy beams. The first space flight of a Medipix-based detector is currently planned for the first quarter of 2012 onboard the UK TechDemoSat-1 satellite as part of the LUCID project. The instrument to be flown is currently planned to have 5 TimePix versions of the Medipix2 detector deployed on 5 of the 6 faces of a cube with ∼3 cm on each side and enclosed by a 0.7 mm thick Al cylindrical cover. The planned orbit will have an altitude of 660 km and will be sun-synchronous with an inclination of 98°Current plans are for the instrument to be located on a vertical side of the satellite with one face upward, one downward, two opposed laterally and one facing in the forward direction with respect to the satellite’s velocity vector. As such, the instrument should be exposed to the outer belt electrons during polar passes as well as the South Atlantic Anomaly and ambient Galactic

  15. 16th International Workshop on Neutrino Factories and Future Neutrino Beam Facilities

    CERN Document Server

    2015-01-01

    These proceedings present the written contributions from participants of the 16th International Workshop on Neutrino Factories and Future Neutrino Beam Facilities (NUFACT 2014) that was held at the University of Glasgow (Glasgow, Scotland, United Kingdom) from 25-30 August 2014. This edition of the NUFACT annual meetings, which started in 1999, consisted of 24 plenary and 92 parallel talks and various poster sessions, with the participation of 124 delegates. Furthermore, the International Neutrino Summer School 2014 was held from 10-22 August 2014 at St Andrews, Scotland, in the two weeks before NUFACT 2014. It was intended for young scientists with an interest in neutrino physics in such a way that they would be able to participate and contribute to the NUFACT workshop as well. The objectives of the NUFACT workshops are to review progress on different studies for future accelerator-based neutrino oscillation facilities, with the goal to discover the mass hierarchy of neutrinos, CP violation in the leptonic s...

  16. Relative and absolute dosimetry of proton therapy beams

    International Nuclear Information System (INIS)

    Mazal, A.; Delacroix, S.; Bridier, A.; Daures, J.; Dolo, J.M.; Nauraye, C.; Ferrand, R.; Cosgrave, V.; Habrand, J.L.

    1995-01-01

    Different codes of practice are in use or under preparation by several groups and national or international societies, concerning the dosimetry of proton beams. In spite of a large number of experiences and the increasing interest on this field, there are still large incertitudes on some of the basic conversion and correction factors to get dose values from different measuring methods. In practice, dose uniformity between centers is searched and encouraged by intercomparisons using standard procedures. We present the characteristics and the results on proton dosimetry intercomparisons using calorimeters, Faraday cups and ion chambers, as well as on the use of other detectors like diodes, radiographic films and TLD. New detectors like diamond, scintillators, radiochromic films, alanine, gels, ... can give new solutions to particular problems, provided their response is not affected at the end of the proton range (higher LET region), and their resolution, range, linearity, cost, ... are well adapted to practical situations. Some examples of special challenges are non interfering measurements during treatments for quality control, in vivo measurements, small beams for stereotactic irradiations, scanned beams and correlations between dosimetry, microdosimetry and radiobiology

  17. External beam radiation therapy for recurrent sigmoid colorectal cancer. Retrospective analysis by group comparison between the radiation therapy alone and the radiation therapy combined with other therapies

    International Nuclear Information System (INIS)

    Churei, Hisahiko; Takeshita, Tsuyoshi; Hiraki, Yoshiyuki; Baba, Yasutaka; Hokotate, Hirohumi; Nakajo, Masayuki; Ohkubo, Kouichi; Miyaji, Noriaki

    1999-01-01

    The purpose of this study is to evaluate retrospectively clinical efficacy of curativeintent external beam radiation therapy for recurrent sigmoid colorectal cancer. As the radiation therapy of higher dose level combined with other therapies might improve pain control, tumor response, and prognosis, the total dose over 60 Gy was delivered except cases that were received surgery for the recurrent tumor. The study population consisted of 25 patients received the radiation therapy alone (RTA) and 24 patients received the radiation therapy combined with other one or two treatment modalities (RTC), which included surgery (tumor resection) in 15 cases, chemotherapy (low dose daily CDDP) in 13 cases, and hyperthermia in 6 cases. They received the radiation therapy from January, 1989 to June, 1996. Data on pain relief and tumor response were compared between the groups of RTA and RTC. The effect on pain relief was not different between the two groups. Tumor response appeared to be high in the patients combined with chemotherapy, but the difference was not statistically significant between the groups. There were no differences in the prognosis by the recurrent tumor size, the pain relief, and the tumor response. There was a statistically significant difference in the prognosis between the groups with and without extrapelvic distant metastases. A more effective treatment modality combined with the external radiation therapy is necessary to improve the clinical efficacy for the recurrent sigmoid colorectal cancer. (author)

  18. The potential of proton beam radiation therapy in lung cancer (including mesothelioma)

    Energy Technology Data Exchange (ETDEWEB)

    Bjelkengren, Goeran [Univ. Hospital, Malmoe (Sweden). Dept. of Oncology; Glimelius, Bengt [Karolinska Inst., Stockholm (Sweden). Dept. of Oncology and Pathology; Akademiska sjukhuset, Uppsala (Sweden). Dept. of Oncology, Radiology and Clinical Immunology

    2005-12-01

    A Swedish group of oncologists and hospital physicists have estimated the number of patients in Sweden suitable for proton beam therapy. The estimations have been based on current statistics of tumour incidence, number of patients potentially eligible for radiation treatment, scientific support from clinical trials and model dose planning studies and knowledge of the dose-response relations of different tumours and normal tissues. It is estimated that about 350 patients with lung cancer and about 20 patients with mesothelioma annually may benefit from proton beam therapy.

  19. The influence of lateral beam profile modifications in scanned proton and carbon ion therapy: a Monte Carlo study

    CERN Document Server

    Parodi, K; Kraemer, M; Sommerer, F; Naumann, J; Mairani, A; Brons, S

    2010-01-01

    Scanned ion beam delivery promises superior flexibility and accuracy for highly conformal tumour therapy in comparison to the usage of passive beam shaping systems. The attainable precision demands correct overlapping of the pencil-like beams which build up the entire dose distribution in the treatment field. In particular, improper dose application due to deviations of the lateral beam profiles from the nominal planning conditions must be prevented via appropriate beam monitoring in the beamline, prior to the entrance in the patient. To assess the necessary tolerance thresholds of the beam monitoring system at the Heidelberg Ion Beam Therapy Center, Germany, this study has investigated several worst-case scenarios for a sensitive treatment plan, namely scanned proton and carbon ion delivery to a small target volume at a shallow depth. Deviations from the nominal lateral beam profiles were simulated, which may occur because of misaligned elements or changes of the beam optic in the beamline. Data have been an...

  20. Quantum beams

    International Nuclear Information System (INIS)

    Uesaka, Mitsuru

    2003-01-01

    Present state and future prospect are described on quantum beams for medical use. Efforts for compactness of linac for advanced cancer therapy have brought about the production of machines like Accuray's CyberKnife and TOMOTHERAPY (Tomo Therapy Inc.) where the acceleration frequency of X-band (9-11 GHz) is used. For cervical vein angiography by the X-band linac, a compact hard X-ray source is developed which is based on the (reverse) Compton scattering through laser-electron collision. More intense beam and laser are necessary at present. A compact machine generating the particle beam of 10 MeV-1 GeV (laser-plasma accelerator) for cancer therapy is also developed using the recent compression technique (chirped-pulse amplification) to generate laser of >10 TW. Tokyo University is studying for the electron beam with energy of GeV order, for the laser-based synchrotron X-ray, and for imaging by the short pulse ion beam. Development of advanced compact accelerators is globally attempted. In Japan, a virtual laboratory by National Institute of Radiological Sciences (NIRS), a working group of universities and research facilities through the Ministry of Education, Culture, Sports, Science and Technology, started in 2001 for practical manufacturing of the above-mentioned machines for cancer therapy and for angiography. Virtual Factory (Inc.), a business venture, is to be stood in future. (N.I.)

  1. Measurements of the fast ion distribution during neutral beam injection and ion cyclotron heating in ATF [Advanced Toroidal Facility

    International Nuclear Information System (INIS)

    Wade, M.R.; Kwon, M.; Thomas, C.E.; Colchin, R.J.; England, A.C.; Gossett, J.M.; Horton, L.D.; Isler, R.C.; Lyon, J.F.; Rasmussen, D.A.; Rayburn, T.M.; Shepard, T.D.; Bell, G.L.; Fowler, R.H.; Morris, R.N.

    1990-01-01

    A neutral particle analyzer (NPA) with horizontal and vertical scanning capability has been used to make initial measurements of the fast ion distribution during neutral beam injection (NBI) and ion cyclotron heating (ICH) on the Advanced Toroidal Facility (ATF). These measurements are presented and compared with the results of modeling codes that predict the analyzer signals during these heating processes. 6 refs., 5 figs

  2. Measurement of secondary radiation during ion beam therapy with the pixel detector Timepix

    Science.gov (United States)

    Martišíková, Mária; Jakubek, Jan; Granja, Carlos; Hartmann, Bernadette; Opálka, Lukáš; Pospíšil, Stanislav; Jäkel, Oliver

    2011-11-01

    In ion beam therapy the finite range of the ion beams in tissue and the presence of the Bragg-peak are exploited. Unpredictable changes in the patient`s condition can alter the range of the ion beam in the body. Therefore it is desired to verify the actual ion range during the treatment, preferably in a non-invasive way. Positron emission tomography (PET) has been used successfully to monitor the applied dose distributions. This method however suffers from limited applicability and low detection efficiency. In order to increase the detection efficiency and to decrease the uncertainties, in this study we investigate the possibility to measure secondary charged particles emerging from the patient during irradiation. An initial experimental study to register the particle radiation coming out of a patient phantom during the therapy was performed at the Heidelberg Ion Beam Therapy Center (HIT) in Germany. A static narrowly-focused beam of carbon ions was directed into a head phantom. The emerging secondary radiation was measured with the position-sensitive Timepix detector outside of the phantom. The detector, developed by the Medipix Collaboration, consists of a silicon sensor bump bonded to a pixelated readout chip (256 × 256 pixels with 55 μm pitch). Together with the USB-based readout interface, Timepix can operate as an active nuclear emulsion registering single particles online with 2D-track visualization. In this contribution we measured the signal behind the head phantom and investigated its dependence on the beam energy (corresponding to beam range in water 2-30 cm). Furthermore, the response was measured at four angles between 0 and 90 degrees. At all investigated energies some signal was registered. Its pattern corresponds to ions. Differences in the total amount of signal for different beam energies were observed. The time-structure of the signal is correlated with that of the incoming beam, showing that we register products of prompt processes. Such

  3. Measurement of secondary radiation during ion beam therapy with the pixel detector Timepix

    International Nuclear Information System (INIS)

    Martišíková, Mária; Hartmann, Bernadette; Jäkel, Oliver; Jakubek, Jan; Granja, Carlos; Opálka, Lukáš; Pospíšil, Stanislav

    2011-01-01

    In ion beam therapy the finite range of the ion beams in tissue and the presence of the Bragg-peak are exploited. Unpredictable changes in the patient's condition can alter the range of the ion beam in the body. Therefore it is desired to verify the actual ion range during the treatment, preferably in a non-invasive way. Positron emission tomography (PET) has been used successfully to monitor the applied dose distributions. This method however suffers from limited applicability and low detection efficiency. In order to increase the detection efficiency and to decrease the uncertainties, in this study we investigate the possibility to measure secondary charged particles emerging from the patient during irradiation. An initial experimental study to register the particle radiation coming out of a patient phantom during the therapy was performed at the Heidelberg Ion Beam Therapy Center (HIT) in Germany. A static narrowly-focused beam of carbon ions was directed into a head phantom. The emerging secondary radiation was measured with the position-sensitive Timepix detector outside of the phantom. The detector, developed by the Medipix Collaboration, consists of a silicon sensor bump bonded to a pixelated readout chip (256 × 256 pixels with 55 μm pitch). Together with the USB-based readout interface, Timepix can operate as an active nuclear emulsion registering single particles online with 2D-track visualization. In this contribution we measured the signal behind the head phantom and investigated its dependence on the beam energy (corresponding to beam range in water 2–30 cm). Furthermore, the response was measured at four angles between 0 and 90 degrees. At all investigated energies some signal was registered. Its pattern corresponds to ions. Differences in the total amount of signal for different beam energies were observed. The time-structure of the signal is correlated with that of the incoming beam, showing that we register products of prompt processes. Such

  4. A novel diamond-based beam position monitoring system for the High Radiation to Materials facility at CERN SPS

    CERN Document Server

    AUTHOR|(CDS)2092886; Höglund, Carina

    The High Radiation to Materials facility employs a high intensity pulsed beam imposing several challenges on the beam position monitors. Diamond has been shown to be a resilient material with its radiation hardness and mechanical strength, while it is also simple due to its wide bandgap removing the need for doping. A new type of diamond based beam position monitor has been constructed, which includes a hole in the center of the diamond where the majority of the beam is intended to pass through. This increases the longevity of the detectors as well as allowing them to be used for high intensity beams. The purpose of this thesis is to evaluate the performance of the detectors in the High Radiation to Materials facility for various beam parameters, involving differences in position, size, bunch intensity and bunch number. A prestudy consisting of calibration of the detectors using single incident particles is also presented. The detectors are shown to work as intended after a recalibration of the algorithm, alb...

  5. Use of the TACL [Thaumaturgic Automated Control Logic] system at CEBAF [Continuous Electron Beam Accelerator Facility] for control of the Cryogenic Test Facility

    International Nuclear Information System (INIS)

    Navarro, E.; Keesee, M.; Bork, R.; Grubb, C.; Lahti, G.; Sage, J.

    1989-01-01

    A logic-based control software system, called Thaumaturgic Automated Control Logic (TACL), is under development at the Continuous Electron Beam Accelerator Facility in Newport News, VA. The first version of the software was placed in service in November, 1987 for control of cryogenics during the first superconducting RF cavity tests at CEBAF. In August, 1988 the control system was installed at the Cryogenic Test Facility (CTF) at CEBAF. CTF generated liquid helium in September, 1988 and is now in full operation for the current round of cavity tests. TACL is providing a powerful and flexible controls environment for the operation of CTF. 3 refs

  6. The National Center for Oncological Hadron Therapy: status of the project and future clinical use of the facility.

    Science.gov (United States)

    Orecchia, Roberto; Fossati, Piero; Rossi, Sandro

    2009-01-01

    Hadron therapy is an advanced radiotherapy technique that employs charged particle beams. Several particles (pions, oxygen, neon and helium ions) have been investigated in the past, but at present only protons and carbon ions are used in clinical practice. Hadron therapy has been used for more than 50 years, more than 50,000 patients have been treated worldwide, and many new facilities are being built. Indications are still a matter of debate. The Italian National Center for Oncological Hadron Therapy (CNAO) is under construction in Pavia and will begin to treat patients in the near future. The CNAO will be a center capable of using both protons and carbon ions. In the first phase, three rooms with vertical and horizontal fixed beams will be available, subsequently the center will be upgraded with two more rooms equipped with a rotating gantry. The facility will use active scanning delivery systems and state-of-the-art immobilization and setup verification devices. One additional room will be devoted to physical and radiobiological research. The CNAO will be a high-patient-throughput facility capable of treating more than 3,000 patients per year. Seven areas of interest have been identified: lung cancer, liver cancer, head and neck malignancies, pediatric solid cancers, eye tumors, sarcoma and central nervous system cancers. A disease-specific working group has been created for each area and has defined selection criteria and protocols to be used at the CNAO. Two more working groups are being set up on gynecological and digestive (pancreas, biliary tract and rectum) tumors. All the patients will participate in clinical trials to establish with sound evidence the real indications for hadron therapy. National and international cooperation networks are being set up to facilitate patient referral and follow-up. A medical service is already operative to assist patients and in selected case to refer them abroad. The CNAO will be the only carbon ion facility in Italy and

  7. High Energy Beam Impact Tests on a LHC Tertiary Collimator at CERN HiRadMat Facility

    CERN Document Server

    Cauchi, M; Assmann, R; Bertarelli, A; Carra, F; Dallocchio, A; Deboy, D; Redaelli, S; Rossi, A; Salvachua, B; Lari, L; Mollicone, P; Sammut, N

    2013-01-01

    The correct functioning of the collimation system is crucial to safelyoperate the LHC. The requirements to handle high intensity beams can be demanding. In this respect, investigating the consequences of LHC particle beams hitting tertiary collimators (TCTs) in the experimental regions is a fundamental issue for machine protection. An experimental test was designed to investigate the robustness and effects of beam accidents on a fully assembled collimator, based on accident scenarios in the LHC. This experiment, carried out at the CERN HiRadMat (High Irradiation to Materials) facility, involved 440 GeV beam impacts of different intensities on the jaws of a horizontal TCT. This paper presents the experimental setup and the preliminary results obtained together with some first outcomes from visual inspection.

  8. High energy beam impact tests on a LHC tertiary collimator at the CERN high-radiation to materials facility

    Directory of Open Access Journals (Sweden)

    Marija Cauchi

    2014-02-01

    Full Text Available The correct functioning of a collimation system is crucial to safely operate highly energetic particle accelerators, such as the Large Hadron Collider (LHC. The requirements to handle high intensity beams can be demanding. In this respect, investigating the consequences of LHC particle beams hitting tertiary collimators (TCTs in the experimental regions is a fundamental issue for machine protection. An experimental test was designed to investigate the robustness and effects of beam accidents on a fully assembled collimator, based on accident scenarios in the LHC. This experiment, carried out at the CERN High-Radiation to Materials (HiRadMat facility, involved 440 GeV proton beam impacts of different intensities on the jaws of a horizontal TCT. This paper presents the experimental setup and the preliminary results obtained, together with some first outcomes from visual inspection and a comparison of such results with numerical simulations.

  9. Treatment of cancer of the pancreas by precision high dose (PHD) external photon beam and intraoperative electron beam therapy (IOEBT)

    International Nuclear Information System (INIS)

    Dobelbower, R.R. Jr.; Howard, J.M.; Bagne, F.R.; Eltaki, A.; Merrick, H.W. III

    1989-01-01

    Twenty-five patients with a diagnosis of unresectable adenocarcinoma of the pancreas were explored in the Clement O. Miniger (COMROC) IOEBT operating amphitheater at the Medical College of Ohio. Seventeen were treated with IOEBT (20-30 Gy, 15 or 18 meV electrons) PHD external beam radiation therapy (40-60 Gy, 1.8 Gy per fraction) plus appropriate operative biliary and gastrointestinal bypass procedures. No intraoperative complications were observed. Two patients died of causes that may have been treatment-related. Two patients developed abdominocutaneous fistulae. Pain was ameliorated in eleven of twelve patients. Jaundice was relieved in all patients. Four of ten patients with weight loss showed a reversal of that trend. Patient survival was not significantly different from that of patients treated with high-dose precision therapy alone

  10. Radioactive Ion Beams and Radiopharmaceuticals

    Science.gov (United States)

    Laxdal, R. E.; Morton, A. C.; Schaffer, P.

    2014-02-01

    Experiments performed at radioactive ion beam facilities shed new light on nuclear physics and nuclear structure, as well as nuclear astrophysics, materials science and medical science. The many existing facilities, as well as the new generation of facilities being built and those proposed for the future, are a testament to the high interest in this rapidly expanding field. The opportunities inherent in radioactive beam facilities have enabled the search for radioisotopes suitable for medical diagnosis or therapy. In this article, an overview of the production techniques and the current status of RIB facilities and proposals will be presented. In addition, accelerator-generated radiopharmaceuticals will be reviewed.

  11. First full-beam PET acquisitions in proton therapy with a modular dual-head dedicated system

    Science.gov (United States)

    Sportelli, G.; Belcari, N.; Camarlinghi, N.; Cirrone, G. A. P.; Cuttone, G.; Ferretti, S.; Kraan, A.; Ortuño, J. E.; Romano, F.; Santos, A.; Straub, K.; Tramontana, A.; Del Guerra, A.; Rosso, V.

    2014-01-01

    During particle therapy irradiation, positron emitters with half-lives ranging from 2 to 20 min are generated from nuclear processes. The half-lives are such that it is possible either to detect the positron signal in the treatment room using an in-beam positron emission tomography (PET) system, right after the irradiation, or to quickly transfer the patient to a close PET/CT scanner. Since the activity distribution is spatially correlated with the dose, it is possible to use PET imaging as an indirect method to assure the quality of the dose delivery. In this work, we present a new dedicated PET system able to operate in-beam. The PET apparatus consists in two 10 cm × 10 cm detector heads. Each detector is composed of four scintillating matrices of 23 × 23 LYSO crystals. The crystal size is 1.9 mm × 1.9 mm × 16 mm. Each scintillation matrix is read out independently with a modularized acquisition system. The distance between the two opposing detector heads was set to 20 cm. The system has very low dead time per detector area and a 3 ns coincidence window, which is capable to sustain high single count rates and to keep the random counts relatively low. This allows a new full-beam monitoring modality that includes data acquisition also while the beam is on. The PET system was tested during the irradiation at the CATANA (INFN, Catania, Italy) cyclotron-based proton therapy facility. Four acquisitions with different doses and dose rates were analysed. In all cases the random to total coincidences ratio was equal or less than 25%. For each measurement we estimated the accuracy and precision of the activity range on a set of voxel lines within an irradiated PMMA phantom. Results show that the inclusion of data acquired during the irradiation, referred to as beam-on data, improves both the precision and accuracy of the range measurement with respect to data acquired only after irradiation. Beam-on data alone are enough to give precisions better than 1 mm

  12. Sweeping-window arc therapy: an implementation of rotational IMRT with automatic beam-weight calculation

    International Nuclear Information System (INIS)

    Cameron, C

    2005-01-01

    Sweeping-window arc therapy (SWAT) is a variation of intensity-modulated radiation therapy (IMRT) with direct aperture optimization (DAO) that is initialized with a leaf sequence of sweeping windows that move back and forth periodically across the target as the gantry rotates. This initial sequence induces modulation in the dose and is assumed to be near enough to a minimum to allow successful optimization, done with simulated annealing, without requiring excessive leaf speeds. Optimal beam weights are calculated analytically, with easy extension to allow for variable beam weights. In this paper SWAT is tested on a phantom model and clinical prostate case. For the phantom, constant and variable beam weights are used. Although further work (in particular, improving the dose model) is required, the results show SWAT to be a feasible approach to generating deliverable dynamic arc treatments that are optimized

  13. A Multiple-room, Continuous Beam Delivery, Hadron-therapy Installation

    Science.gov (United States)

    Méot, F.

    A proton-therapy hospital installation, based on multiple beam extraction systems from a fixed-field synchrotron, is presented and commented. Potential interest as hospital operation efficiency, as well as estimates of the impact of continuous, multiple-port extraction, on the cost of a session, are discussed.

  14. Comparison of LSO and BGO block detectors for prompt gamma imaging in ion beam therapy

    NARCIS (Netherlands)

    Hueso-Gonzalez, F.; Biegun, A. K.; Dendooven, P.; Enghardt, W.; Fiedler, F.; Golnik, C.; Heidel, K.; Kormoll, T.; Petzoldt, J.; Roemer, K. E.; Schwengner, R.; Wagner, A.; Pausch, G.

    A major weakness of ion beam therapy is the lack of tools for verifying the particle range in clinical routine. The application of the Compton camera concept for the imaging of prompt gamma rays, a by-product of the irradiation correlated to the dose distribution, is a promising approach for range

  15. Parallel processing of dose calculation for external photon beam therapy

    International Nuclear Information System (INIS)

    Kunieda, Etsuo; Ando, Yutaka; Tsukamoto, Nobuhiro; Ito, Hisao; Kubo, Atsushi

    1994-01-01

    We implemented external photon beam dose calculation programs into a parallel processor system consisting of Transputers, 32-bit processors especially suitable for multi-processor configuration. Two network conformations, binary-tree and pipeline, were evaluated for rectangular and irregular field dose calculation algorithms. Although computation speed increased in proportion to the number of CPU, substantial overhead caused by inter-processor communication occurred when a smaller computation load was delivered to each processor. On the other hand, for irregular field calculation, which requires more computation capability for each calculation point, the communication overhead was still less even when more than 50 processors were involved. Real-time responses could be expected for more complex algorithms by increasing the number of processors. (author)

  16. Practical use of a plastic scintillator for quality assurance of electron beam therapy

    Science.gov (United States)

    Yogo, Katsunori; Tatsuno, Yuya; Tsuneda, Masato; Aono, Yuki; Mochizuki, Daiki; Fujisawa, Yoshiki; Matsushita, Akihiro; Ishigami, Minoru; Ishiyama, Hiromichi; Hayakawa, Kazushige

    2017-06-01

    Quality assurance (QA) of clinical electron beams is essential for performing accurate and safe radiation therapy. However, with advances in radiation therapy, QA has become increasingly labor-intensive and time-consuming. In this paper, we propose a tissue-equivalent plastic scintillator for quick and easy QA of clinical electron beams. The proposed tool comprises a plastic scintillator plate and a charge-coupled device camera that enable the scintillation light by electron beams to be recorded with high sensitivity and high spatial resolution. Further, the Cerenkov image is directly subtracted from the scintillation image to discriminate Cerenkov emissions and accurately measure the dose profiles of electron beams with high spatial resolution. Compared with conventional methods, discrepancies in the depth profile improved from 7% to 2% in the buildup region via subtractive corrections. Further, the output brightness showed good linearity with dose, good reproducibility (deviations below 1%), and dose rate independence (within 0.5%). The depth of 50% dose measured with the tool, an index of electron beam quality, was within  ±0.5 mm of that obtained with an ionization chamber. Lateral brightness profiles agreed with the lateral dose profiles to within 4% and no significant improvement was obtained using Cerenkov corrections. Field size agreed to within 0.5 mm with those obtained with ionization chamber. For clinical QA of electron boost treatment, a disk scintillator that mimics the shape of a patient’s breast is applied. The brightness distribution and dose, calculated using a treatment planning system, was generally acceptable for clinical use, except in limited zones. Overall, the proposed plastic scintillator plate tool efficiently performs QA for electron beam therapy and enables simultaneous verification of output constancy, beam quality, depth, and lateral dose profiles during monthly QAs at lower doses of irradiation (small monitor units, MUs).

  17. Practical use of a plastic scintillator for quality assurance of electron beam therapy.

    Science.gov (United States)

    Yogo, Katsunori; Tatsuno, Yuya; Tsuneda, Masato; Aono, Yuki; Mochizuki, Daiki; Fujisawa, Yoshiki; Matsushita, Akihiro; Ishigami, Minoru; Ishiyama, Hiromichi; Hayakawa, Kazushige

    2017-06-07

    Quality assurance (QA) of clinical electron beams is essential for performing accurate and safe radiation therapy. However, with advances in radiation therapy, QA has become increasingly labor-intensive and time-consuming. In this paper, we propose a tissue-equivalent plastic scintillator for quick and easy QA of clinical electron beams. The proposed tool comprises a plastic scintillator plate and a charge-coupled device camera that enable the scintillation light by electron beams to be recorded with high sensitivity and high spatial resolution. Further, the Cerenkov image is directly subtracted from the scintillation image to discriminate Cerenkov emissions and accurately measure the dose profiles of electron beams with high spatial resolution. Compared with conventional methods, discrepancies in the depth profile improved from 7% to 2% in the buildup region via subtractive corrections. Further, the output brightness showed good linearity with dose, good reproducibility (deviations below 1%), and dose rate independence (within 0.5%). The depth of 50% dose measured with the tool, an index of electron beam quality, was within  ±0.5 mm of that obtained with an ionization chamber. Lateral brightness profiles agreed with the lateral dose profiles to within 4% and no significant improvement was obtained using Cerenkov corrections. Field size agreed to within 0.5 mm with those obtained with ionization chamber. For clinical QA of electron boost treatment, a disk scintillator that mimics the shape of a patient's breast is applied. The brightness distribution and dose, calculated using a treatment planning system, was generally acceptable for clinical use, except in limited zones. Overall, the proposed plastic scintillator plate tool efficiently performs QA for electron beam therapy and enables simultaneous verification of output constancy, beam quality, depth, and lateral dose profiles during monthly QAs at lower doses of irradiation (small monitor units, MUs).

  18. Individualized Selection of Beam Angles and Treatment Isocenter in Tangential Breast Intensity Modulated Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Penninkhof, Joan, E-mail: j.penninkhof@erasmusmc.nl [Department of Radiation Oncology, Erasmus M.C. Cancer Institute, Rotterdam (Netherlands); Spadola, Sara [Department of Radiation Oncology, Erasmus M.C. Cancer Institute, Rotterdam (Netherlands); Department of Physics and Astronomy, Alma Mater Studiorum, University of Bologna, Bologna (Italy); Breedveld, Sebastiaan; Baaijens, Margreet [Department of Radiation Oncology, Erasmus M.C. Cancer Institute, Rotterdam (Netherlands); Lanconelli, Nico [Department of Physics and Astronomy, Alma Mater Studiorum, University of Bologna, Bologna (Italy); Heijmen, Ben [Department of Radiation Oncology, Erasmus M.C. Cancer Institute, Rotterdam (Netherlands)

    2017-06-01

    Purpose and Objective: Propose a novel method for individualized selection of beam angles and treatment isocenter in tangential breast intensity modulated radiation therapy (IMRT). Methods and Materials: For each patient, beam and isocenter selection starts with the fully automatic generation of a large database of IMRT plans (up to 847 in this study); each of these plans belongs to a unique combination of isocenter position, lateral beam angle, and medial beam angle. The imposed hard planning constraint on patient maximum dose may result in plans with unacceptable target dose delivery. Such plans are excluded from further analyses. Owing to differences in beam setup, database plans differ in mean doses to organs at risk (OARs). These mean doses are used to construct 2-dimensional graphs, showing relationships between: (1) contralateral breast dose and ipsilateral lung dose; and (2) contralateral breast dose and heart dose (analyzed only for left-sided). The graphs can be used for selection of the isocenter and beam angles with the optimal, patient-specific tradeoffs between the mean OAR doses. For 30 previously treated patients (15 left-sided and 15 right-sided tumors), graphs were generated considering only the clinically applied isocenter with 121 tangential beam angle pairs. For 20 of the 30 patients, 6 alternative isocenters were also investigated. Results: Computation time for automatic generation of 121 IMRT plans took on average 30 minutes. The generated graphs demonstrated large variations in tradeoffs between conflicting OAR objectives, depending on beam angles and patient anatomy. For patients with isocenter optimization, 847 IMRT plans were considered. Adding isocenter position optimization next to beam angle optimization had a small impact on the final plan quality. Conclusion: A method is proposed for individualized selection of beam angles in tangential breast IMRT. This may be especially important for patients with cardiac risk factors or an

  19. On-line image guided radiation therapy using cone-beam CT (CBCT)

    International Nuclear Information System (INIS)

    Bak, Jin O; Park, Suk Won; Jeong, Kyung Keun; Keum, Ki Chang

    2006-01-01

    Using cone beam CT, we can compare the position of the patients at the simulation and the treatment. In on-line image guided radiation therapy, one can utilize this compared data and correct the patient position before treatments. Using cone beam CT, we investigated the errors induced by setting up the patients when use only the markings on the patients' skin. We obtained the data of three patients that received radiation therapy at the Department of Radiation Oncology in Chung-Ang University during August 2006 and October 2006. Just as normal radiation therapy, patients were aligned on the treatment couch after the simulation and treatment planning. Patients were aligned with lasers according to the marking on the skin that were marked at the simulation time and then cone beam CTs were obtained. Cone beam CTs were fused and compared with simulation CTs and the displacement vectors were calculated. Treatment couches were adjusted according to the displacement vector before treatments. After the treatment, positions were verified with kV X-ray (OBI system). In the case of head and neck patients, the average sizes of the setup error vectors, given by the cone beam CT, were 0.19 cm for the patient A and 0.18 cm for the patient B. The standard deviations were 0.15 cm and 0.21 cm, each. On the other hand, in the case of the pelvis patient, the average and the standard deviation were 0.37 cm and 01 cm. Through the on-line IGRT using cone beam CT, were could correct the setup errors that could occur in the conventional radiotherapy. The importance of the on-line IGRT should be emphasized in the case of 3D conformal therapy and intensity-modulated radiotherapy, which have complex target shapes and steep dose gradients

  20. Cost-effectiveness analysis of cochlear dose reduction by proton beam therapy for medulloblastoma in childhood

    International Nuclear Information System (INIS)

    Hirano, Emi; Kawabuchi, Koichi; Fuji, Hiroshi; Onoe, Tsuyoshi; Kumar, Vinay; Shirato, Hiroki

    2014-01-01

    The aim of this study is to evaluate the cost-effectiveness of proton beam therapy with cochlear dose reduction compared with conventional X-ray radiotherapy for medulloblastoma in childhood. We developed a Markov model to describe health states of 6-year-old children with medulloblastoma after treatment with proton or X-ray radiotherapy. The risks of hearing loss were calculated on cochlear dose for each treatment. Three types of health-related quality of life (HRQOL) of EQ-5D, HUI3 and SF-6D were used for estimation of quality-adjusted life years (QALYs). The incremental cost-effectiveness ratio (ICER) for proton beam therapy compared with X-ray radiotherapy was calculated for each HRQOL. Sensitivity analyses were performed to model uncertainty in these parameters. The ICER for EQ-5D, HUI3 and SF-6D were $21 716/QALY, $11 773/QALY, and $20 150/QALY, respectively. One-way sensitivity analyses found that the results were sensitive to discount rate, the risk of hearing loss after proton therapy, and costs of proton irradiation. Cost-effectiveness acceptability curve analysis revealed a 99% probability of proton therapy being cost effective at a societal willingness-to-pay value. Proton beam therapy with cochlear dose reduction improves health outcomes at a cost that is within the acceptable cost-effectiveness range from the payer's standpoint. (author)

  1. New x-ray parallel beam facility XPBF 2.0 for the characterization of silicon pore optics

    Science.gov (United States)

    Krumrey, Michael; Müller, Peter; Cibik, Levent; Collon, Max; Barrière, Nicolas; Vacanti, Giuseppe; Bavdaz, Marcos; Wille, Eric

    2016-07-01

    A new X-ray parallel beam facility (XPBF 2.0) has been installed in the laboratory of the Physikalisch-Technische Bundesanstalt at the synchrotron radiation facility BESSY II in Berlin to characterize silicon pore optics (SPOs) for the future X-ray observatory ATHENA. As the existing XPBF which is operated since 2005, the new beamline provides a pencil beam of very low divergence, a vacuum chamber with a hexapod system for accurate positioning of the SPO to be investigated, and a vertically movable CCD-based camera system to register the direct and the reflected beam. In contrast to the existing beamline, a multilayer-coated toroidal mirror is used for beam monochromatization at 1.6 keV and collimation, enabling the use of beam sizes between about 100 μm and at least 5 mm. Thus the quality of individual pores as well as the focusing properties of large groups of pores can be investigated. The new beamline also features increased travel ranges for the hexapod to cope with larger SPOs and a sample to detector distance of 12 m corresponding to the envisaged focal length of ATHENA.

  2. Preventing vacuum leaks in the Continuous Electron Beam Accelerator Facility cavity pair bellows

    International Nuclear Information System (INIS)

    Henkel, D.P.; Doolittle, L.R.

    1994-01-01

    Occasional vacuum leaks have occurred in bellows assemblies of helium pressure vessels at the Continuous Electron Beam Accelerator Facility. The flanged stainless steel bellows assemblies are used to connect the niobium rf cavity pairs to the surrounding liquid helium pressure vessels. An investigation of the source of these leaks has revealed a through-thickness network of microcracks in the cuff weld zones. The cuff material contained a mixture of soft and very hard elongated intermetallic inclusions that were oriented parallel with the weld fusion line; these inclusions served as crack initiation sites. Surface-exposed inclusions, in contact with a chlorine residue from a postweld machining process, induced crevice corrosion during a year of storage. Residual stresses in the weld led to a combination of lamellar tearing and stress corrosion cracking. Propagation of the cracks from one inclusion to another resulted in continuous vacuum leakage paths from the primary (2 K) helium circuit to the vacuum insulation space. Additional vacuum leaks were prevented by reconfiguring the weld geometry and avoiding any processing with chlorinated substances

  3. Present status of neutron beam facilities at the research reactor, HANARO, and its future prospect

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chang-Hee; Kang, Young-Hwan; Kuk, Il-Hiun [Korea Atomic Energy Research Institute, Taejon (Korea)

    2001-03-01

    Korea has been operating its new research reactor, HANARO, since its first criticality in 1995. It is an open-tank-in-pool type reactor using LEU fuel with thermal neutron flux of 2 x 10{sup 14} nominally at the nose in the D{sub 2}O reflector having 7 horizontal beam ports and a provision of vertical hole for cold neutron source installation. KAERI has pursued an extensive instrument development program since 1992 by the support of the nuclear long-term development program of the government and there are now 4 working instruments. A high resolution powder diffractometer and a neutron radiography facility has been operational since late 1997 and 1996, respectively. A four-circle diffractometer has been fully working since mid 1999 and a small angle neutron spectrometer is just under commissioning phase. With the development of linear position sensitive detector with delay-line readout electronics, we have developed a residual stress instrument as an optional machine to the HRPD for last two years. Around early 1998 informal users program started with friendly users and it became a formal users support program by the ministry of science and technology. Short description for peer group formation and users activities is given. (author)

  4. The RFQ prototype for the radioactive ion beams facility at TRIUMF

    International Nuclear Information System (INIS)

    Poirier, R.L.; Bricault, P.G.; Jensen, K.; Mitra, A.K.

    1996-01-01

    The ISAC radioactive ion beams facility being built at TRIUMF requires cw operation of a low frequency RFQ structure. This implies a large structure with adequate cooling while still maintaining mechanical alignment and stability. Our goal is to achieve a thermal stability alignment of +/-0.08 mm along the entire length of the RFQ structure and a dynamic stability of the operating assembled RFQ structure, taking into account deformation due to thermal drifts and vibrations induced by cooling and vacuum pumps, to within +/- 0.025 mm. Cold model studies have been carried out to confirm the RF characteristics of the RFQ design. To confirm the manufacturability of the design to maintain the above tolerances, a prototype section consisting of three RFQ rings is being fabricated and will be tested to full cw power (85 kV between electrodes). The basic design of the structure is different from other RFQ structures in that the RF surfaces have been de-coupled from the mechanical support structure for improved stability. The features of this mechanical design will be discussed and the first results of the RFQ prototype tests will be presented. (author)

  5. Environmental Management Assessment of the Continuous Electron Beam Accelerator Facility (CEBAF)

    International Nuclear Information System (INIS)

    1993-03-01

    This report documents the results of the Environmental Management Assessment performed at the Continuous Electron Beam Accelerator Facility (CEBAF) in Newport News, Virginia. During this assessment, activities and records were reviewed and interviews were conducted with personnel from the CEBAF Site Office; the CEBAF management and operating contractor (M ampersand O), Southeastern Universities Research Association, Inc. (SURA); the Oak Ridge Field Office (OR); and the responsible DOE Headquarters Program Office, the Office of Energy Research (ER). The onsite portion of the assessment was conducted from March 8 through March 19, 1993, by the US Department of Energy's (DOE's) Office of Environmental Audit (EH-24) located within the office of Environment, Safety and Health (EH). DOE 5482.1 B, ''Environment, Safety and Health Appraisal Program,'' and Secretary of Energy Notice (SEN)-6E-92, ''Departmental Organizational and Management Arrangements,'' establish the mission of EH-24 to provide comprehensive, independent oversight of Department-wide environmental programs on behalf of the Secretary of Energy. The ultimate goal of EH-24 is enhancement of environmental protection and minimization of risk to public health and the environment. EH-24 accomplishes its mission utilizing systematic and periodic evaluations of the Department's environmental programs within line organizations, and through use of supplemental activities which serve to strengthen self-assessment and oversight functions within program, field, and contractor organizations

  6. Present status of neutron beam facilities at the research reactor, HANARO, and its future prospect

    International Nuclear Information System (INIS)

    Lee, Chang-Hee; Kang, Young-Hwan; Kuk, Il-Hiun

    2001-01-01

    Korea has been operating its new research reactor, HANARO, since its first criticality in 1995. It is an open-tank-in-pool type reactor using LEU fuel with thermal neutron flux of 2 x 10 14 nominally at the nose in the D 2 O reflector having 7 horizontal beam ports and a provision of vertical hole for cold neutron source installation. KAERI has pursued an extensive instrument development program since 1992 by the support of the nuclear long-term development program of the government and there are now 4 working instruments. A high resolution powder diffractometer and a neutron radiography facility has been operational since late 1997 and 1996, respectively. A four-circle diffractometer has been fully working since mid 1999 and a small angle neutron spectrometer is just under commissioning phase. With the development of linear position sensitive detector with delay-line readout electronics, we have developed a residual stress instrument as an optional machine to the HRPD for last two years. Around early 1998 informal users program started with friendly users and it became a formal users support program by the ministry of science and technology. Short description for peer group formation and users activities is given. (author)

  7. Workshop on CEBAF [Continuous Electron Beam Accelerator Facility] spectrometer magnet design and technology: Proceedings

    International Nuclear Information System (INIS)

    1986-09-01

    The planned experimental program at CEBAF includes high-resolution, large acceptance spectrometers and a large toroidal magnetic, detector. In order to take full advantage of the high quality beam characteristics, the performances required will make these devices quite unique instruments compared to existing facilities in the same energy range. Preliminary designs have shown that such performances can be reached, but key questions concerning design concepts and most appropriate and cost-effective technologies had to be answered before going further with the designs. It was the purpose of the Workshop on CEBAF Spectrometer Magnet Design and Technology, organized by the CEBAF Research and Engineering Divisions, to provide the most complete information about the state-of-the-art tools and techniques in magnet design and construction and to discuss the ones most appropriate to the CEBAF spectrometers. In addition, it is expected that this Workshop will be the staring point for further interactions and collaborations between international magnet experts and the CEBAF staff, during the whole process of designing and building the spectrometers

  8. Design of Data Acquisition and Control System for Indian Test Facility of Diagnostics Neutral Beam

    International Nuclear Information System (INIS)

    Soni, Jignesh; Tyagi, Himanshu; Yadav, Ratnakar; Rotti, Chandramouli; Bandyopadhyay, Mainak; Bansal, Gourab; Gahluat, Agrajit; Sudhir, Dass; Joshi, Jaydeep; Prasad, Rambilas; Pandya, Kaushal; Shah, Sejal; Parmar, Deepak; Chakraborty, Arun

    2015-01-01

    Highlights: • More than 900 channels Data Acquisition and Control System. • INTF DACS has been designed based on ITER-PCDH guidelines. • Separate Interlock and Safety system designed based on IEC 61508 standard. • Hardware selected from ITER slow controller and fast controller catalog. • Software framework based on ITER CODAC Core System and LabVIEW software. - Abstract: The Indian Test Facility (INTF) – a negative hydrogen ion based 100 kV, 60 A, 5 Hz modulated NBI system having 3 s ON/20 s OFF duty cycle. Prime objective of the facility is to install a full-scale test bed for the qualification of all Diagnostic Neutral Beam (DNB) parameters, prior to installation in ITER. The automated and safe operation of the INTF will require a reliable and rugged instrumentation and control system which provide control, data acquisition (DAQ), interlock and safety functions, referred as INTF-DACS. The INTF-DACS has been decided to be design based on the ITER CODAC architecture and ITER-PCDH guidelines since the technical understanding of CODAC technology gained from this will later be helpful in development of plant system I&C for DNB. For complete operation of the INTF, approximately 900 numbers of signals are required to be superintending by the DACS. In INTF conventional control loop time required is within the range of 5–100 ms and for DAQ except high-end diagnostics, required sampling rates in range of 5 sample per second (Sps) to 10 kSps; to fulfill these requirements hardware components have been selected from the ITER slow and fast controller catalogs. For high-end diagnostics required sampling rates up to 100 MSps normally in case of certain events, therefore event and burst based DAQ hardware has been finalized. Combined use of CODAC core software (CCS) and NI-LabVIEW has been finalized due to the fact that full required DAQ support is not available in present version of CCS. Interlock system for investment protection of facility and Safety system for

  9. Design of Data Acquisition and Control System for Indian Test Facility of Diagnostics Neutral Beam

    Energy Technology Data Exchange (ETDEWEB)

    Soni, Jignesh, E-mail: jsoni@ipr.res.in [Institute for Plasma Research, Bhat, Gandhinagar 382 428, Gujarat (India); Tyagi, Himanshu; Yadav, Ratnakar; Rotti, Chandramouli; Bandyopadhyay, Mainak [ITER-India, Institute for Plasma Research, Gandhinagar 380 025, Gujarat (India); Bansal, Gourab; Gahluat, Agrajit [Institute for Plasma Research, Bhat, Gandhinagar 382 428, Gujarat (India); Sudhir, Dass; Joshi, Jaydeep; Prasad, Rambilas [ITER-India, Institute for Plasma Research, Gandhinagar 380 025, Gujarat (India); Pandya, Kaushal [Institute for Plasma Research, Bhat, Gandhinagar 382 428, Gujarat (India); Shah, Sejal; Parmar, Deepak [ITER-India, Institute for Plasma Research, Gandhinagar 380 025, Gujarat (India); Chakraborty, Arun [Institute for Plasma Research, Bhat, Gandhinagar 382 428, Gujarat (India)

    2015-10-15

    Highlights: • More than 900 channels Data Acquisition and Control System. • INTF DACS has been designed based on ITER-PCDH guidelines. • Separate Interlock and Safety system designed based on IEC 61508 standard. • Hardware selected from ITER slow controller and fast controller catalog. • Software framework based on ITER CODAC Core System and LabVIEW software. - Abstract: The Indian Test Facility (INTF) – a negative hydrogen ion based 100 kV, 60 A, 5 Hz modulated NBI system having 3 s ON/20 s OFF duty cycle. Prime objective of the facility is to install a full-scale test bed for the qualification of all Diagnostic Neutral Beam (DNB) parameters, prior to installation in ITER. The automated and safe operation of the INTF will require a reliable and rugged instrumentation and control system which provide control, data acquisition (DAQ), interlock and safety functions, referred as INTF-DACS. The INTF-DACS has been decided to be design based on the ITER CODAC architecture and ITER-PCDH guidelines since the technical understanding of CODAC technology gained from this will later be helpful in development of plant system I&C for DNB. For complete operation of the INTF, approximately 900 numbers of signals are required to be superintending by the DACS. In INTF conventional control loop time required is within the range of 5–100 ms and for DAQ except high-end diagnostics, required sampling rates in range of 5 sample per second (Sps) to 10 kSps; to fulfill these requirements hardware components have been selected from the ITER slow and fast controller catalogs. For high-end diagnostics required sampling rates up to 100 MSps normally in case of certain events, therefore event and burst based DAQ hardware has been finalized. Combined use of CODAC core software (CCS) and NI-LabVIEW has been finalized due to the fact that full required DAQ support is not available in present version of CCS. Interlock system for investment protection of facility and Safety system for

  10. Normal tissue tolerance to external beam radiation therapy: Skin

    International Nuclear Information System (INIS)

    Ginot, A.; Doyen, J.; Hannoun-Levi, J.M.; Courdi, A.

    2010-01-01

    Acute skin toxicity is frequent during radiation therapy and can lead to temporary arrest of the treatment. Chronic toxicity can occur and conduct to cosmetic problems. Alopecia is the most frequent toxicity concerning hair and is most of the time reversible. Several factors linked to patients influence skin toxicity, such as under-nutrition, old age, obesity, smoking, skin diseases, autoimmune diseases, failure of DNA reparation. Skin, hair and nail toxicities depend also on radiation schedule. Acute toxicity is greater when dose per fraction increases. Chronic and acute toxicities are more often when total dose increases. Under 45 Gy, the risk of severe skin toxicity is low, and begins above 50 Gy. Skin toxicity depends also on the duration of radiotherapy and split course schedules are associated with less toxicities. Irradiation surface seems to influence skin toxicity but interaction is more complex. Reirradiation is often feasible in case of cancer recurrence but with a risk of grade 3-4 toxicity above all in head and neck cancer. The benefit/risk ratio has to be always precisely evaluated. Permanent alopecia is correlated with the follicle dose. Modern techniques of radiation therapy allow to spare skin. (authors)

  11. Normal tissue tolerance to external beam radiation therapy: The mandible

    International Nuclear Information System (INIS)

    Berger, A.; Bensadoun, R.J.

    2010-01-01

    Describing dose constraints for organs at risk in external beam radiotherapy is a key-point in order to maximize the therapeutic ratio. In head and neck irradiation, mandible is frequently exposed to ionising radiation-related complications. Those complications will be exposed after a short description of anatomical and physiopathological aspects. A literature search was performed using the Pubmed-Medline database, with following keywords (Osteoradionecrosis, Radiotherapy, Mandible, Toxicity, Organ at risk, Trismus). Incidence and dose constraints will be reported. The incidence of osteoradionecrosis decreased since the 1990, but it remains a dreaded late complication of head and neck cancer radiotherapy. It essentially occurs with cumulative doses of 66 Gy on the mandible (standard fractionation) applied to a significant volume. Respecting oral care is crucial to avoid this kind of complication. The respect of the dose-constraint described should not lead to under treat tumor bed in a curative intent. Trismus related to ionising radiation is poorly described. Literature data cannot lead to describe precise dose constraints. (authors)

  12. Accelerators and associated research activities at IUAC Delhi: its synergy with ion beam facilities coming up at GGU Bilaspur

    International Nuclear Information System (INIS)

    Kanjilal, D.

    2013-01-01

    A large electrostatic tandem accelerator having highest terminal voltage rating of 16 MV using compressed geometry tubes has been in regular operation at Inter-University Accelerator Center (IUAC) for more than two decades. It has been providing various ions (hydrogen to gold) regularly in the energy range from a few tens of MeV to 270 MeV for scheduled experiments. Three superconducting linac booster modules having niobium quarter wave resonators have been in operation for experiments. The linac modules have been tested and used to accelerate energetic heavy ion beams from the Pelletron Accelerator. A unique high temperature superconducting electron cyclotron resonance ion source (ECRIS) called PKDELIS was designed, fabricated and installed. It has been in regular operation for tests and experiments at IUAC. A high current injector (HCI) system is being developed for injecting highly charged ions having higher intensity into the superconducting linac. A radio frequency quadrupole (RFQ) accelerator is being developed to accelerate highly charged particles (A/Q ∼ 6) to an energy of about 180 keV/A. The beam will then be accelerated further by drift tube linacs (DTL) to the required velocity to inject the ion beams to the linac booster. A low energy ion beam facility consisting of an ECRIS on 400kV platform has been developed for low energy irradiation and implantation. A 1.7 MV Pelletron is installed for Rutherford back scattering and Channeling studies of materials. Ion beams at varied energies and fluences are used for modification of materials at desired location in three dimensions. Some of the experimental activities and associated interesting results on controlled modification of materials using properly selected ion beams will be presented. Fundamental interaction processes involved during and after passage of energetic beams to get the desired results will be discussed. Some of the recent results on production of controlled structures using energetic ion

  13. Modification of the University of Washington Neutron Radiotherapy Facility for optimization of neutron capture enhanced fast-neutron therapy

    International Nuclear Information System (INIS)

    Nigg, David W.; Wemple, Charles A.; Risler, Ruedi; Hartwell, John K.; Harker, Yale D.; Laramore, George E.

    2000-01-01

    A modified neutron production target assembly has been developed to provide improved performance of the proton-cyclotron-based neutron radiotherapy facility at the University of Washington for applications involving neutron capture enhanced fast-neutron therapy. The new target produces a neutron beam that yields essentially the same fast-neutron physical depth-dose distribution as is produced by the current UW clinical system, but that also has an increased fraction of BNCT enhancement relative to the total therapeutic dose. The modified target is composed of a 5-millimeter layer of beryllium, followed by a 2.5-millimeter layer of tungsten, with a water-cooled copper backing. Measurements of the free-field neutron spectrum of the beam produced by the new target were performed using activation foils with a direct spectral unfolding technique. Water phantom measurements were performed using a tissue-equivalent ion chamber to characterize the fast-neutron depth-dose curve and sodium activation in soda-lime glass beads to characterize the thermal-neutron flux (and thus the expected neutron capture dose enhancement) as a function of depth. The results of the various measurements were quite consistent with expectations based on the design calculations for the modified target. The spectrum of the neutron beam produced by the new target features an enhanced low-energy flux component relative to the spectrum of the beam produced by the standard UW target. However, it has essentially the same high-energy neutron flux, with a reduced flux component in the mid-range of the energy spectrum. As a result, the measured physical depth-dose curve in a large water phantom has the same shape compared to the case of the standard UW clinical beam, but approximately twice the level of BNCT enhancement per unit background neutron dose at depths of clinical interest. In-vivo clinical testing of BNCT-enhanced fast-neutron therapy for canine lung tumors using the new beam was recently

  14. Real-time dose compensation methods for scanned ion beam therapy of moving tumors

    International Nuclear Information System (INIS)

    Luechtenborg, Robert

    2012-01-01

    Scanned ion beam therapy provides highly tumor-conformal treatments. So far, only tumors showing no considerable motion during therapy have been treated as tumor motion and dynamic beam delivery interfere, causing dose deteriorations. One proposed technique to mitigate these deteriorations is beam tracking (BT), which adapts the beam position to the moving tumor. Despite application of BT, dose deviations can occur in the case of non-translational motion. In this work, real-time dose compensation combined with beam tracking (RDBT) has been implemented into the control system to compensate these dose changes by adaptation of nominal particle numbers during irradiation. Compared to BT, significantly reduced dose deviations were measured using RDBT. Treatment planning studies for lung cancer patients including the increased biological effectiveness of ions revealed a significantly reduced over-dose level (3/5 patients) as well as significantly improved dose homogeneity (4/5 patients) for RDBT. Based on these findings, real-time dose compensated re-scanning (RDRS) has been proposed that potentially supersedes the technically complex fast energy adaptation necessary for BT and RDBT. Significantly improved conformity compared to re-scanning, i.e., averaging of dose deviations by repeated irradiation, was measured in film irradiations. Simulations comparing RDRS to BT revealed reduced under- and overdoses of the former method.

  15. Normal tissue tolerance to external beam radiation therapy: The stomach

    International Nuclear Information System (INIS)

    Oberdiac, P.; Mineur, L.

    2010-01-01

    In the following article, we will discuss general issues relating to acute and late gastric's radiation toxicities. The tolerance of the stomach to complete or partial organ irradiation is more un-appreciated than for most other organs. We consulted the Medline database via PubMed and used the key words gastric - radiotherapy - toxicity. Currently, 60 Gy or less is prescribed in gastric radiation therapy. Acute clinical toxicity symptoms are predominantly nausea and vomiting. Although there is a general agreement that the whole stomach tolerance is for doses of 40 to 45 Gy without unacceptable complication, it is well established that a stomach dose of 35 Gy increases the risk of ulcer complications. (authors)

  16. New target solution for a muon collider or a muon-decay neutrino beam facility: The granular waterfall target

    Directory of Open Access Journals (Sweden)

    Han-Jie Cai

    2017-02-01

    Full Text Available A new target solution, the granular waterfall target, is proposed here for a muon collider or a muon-decay neutrino beam facility, especially for the moment which adopts a 15 MW continuous-wave (cw superconducting linac. Compared to the mercury jet target, the granular waterfall target works by a much simpler mechanism which can operate with a much more powerful beam, which are indicated by the detailed investigations into the heat depositions and the evaluations of the temperature increases for different target concepts. By varying proton beam kinetic energy and the geometrical parameters of the waterfall target, an overall understanding of the figure of merit concerning muon production for this target concept as the target solutions of the long-baseline neutrino factory and the medium-baseline moment is obtained. With 8 GeV beam energy and the optimal geometrical parameters, the influence on muon yield by adopting different beam-target interaction parameters is explored. Studies and discussions of the design details concerning beam dumping are also presented.

  17. Design of commercial dyeing wastewater treatment facility with e-beam (based on the results of pilot plant)

    International Nuclear Information System (INIS)

    Han, Bumsoo; Kim, Sung Myun; Kim, Jin-Kyu; Kim, Yuri; Yang, Mun Ho; Choi, J.S.; Ahn, S.J.; Pikaev, A.K.; Makarov, I.E.; Ponomarev, A.V.

    2001-01-01

    A pilot plant for a large-scale test of dyeing facility wastewater (flow rate of 1,000m 3 per day from 80,000m 3 /day of total wastewater) was constructed and operated with the electron accelerator of 1MeV, 40kW. The accelerator was installed in February 1998 and the Tower Style Biological treatment facility (TSB) was also installed in October 1998. The wastewater is injected under the e-beam irradiation area through the nozzle type injector to obtain the adequate penetration depth. The speed of injection could be varied upon the dose and dose rate. Performance statistics are given

  18. MO-A-BRB-03: Integration Issues in Electronic Charting for External Beam Therapy

    International Nuclear Information System (INIS)

    Sutlief, S.

    2015-01-01

    The process of converting to an electronic chart for radiation therapy can be daunting. It requires a dedicated committee to first research and choose appropriate software, to review the entire documentation policy and flow of the clinic, to convert this system to electronic form or if necessary, redesign the system to more easily conform to the electronic process. Those making the conversion and those who already use electronic charting would benefit from the shared experience of those who have been through the process in the past. Therefore TG262 was convened to provide guidance on electronic charting for external beam radiation therapy and brachytherapy. This course will present the results of an internal survey of task group members on EMR practices in External Beam Radiation Therapy as well as discuss important issues in EMR development and structure for both EBRT and brachytherapy. Learning Objectives: Be familiarized with common practices and pitfalls in development and maintenance of an electronic chart in Radiation Oncology Be familiarized with important issues related to electronic charting in External Beam Radiation Therapy Be familiarized with important issues related to electronic charting in Brachytherapy

  19. Visual Outcomes of Parapapillary Uveal Melanomas Following Proton Beam Therapy

    International Nuclear Information System (INIS)

    Thariat, Juliette; Grange, Jean-Daniel; Mosci, Carlo; Rosier, Laurence; Maschi, Celia; Lanza, Francesco; Nguyen, Anh Minh; Jaspart, Franck; Bacin, Franck; Bonnin, Nicolas; Gaucher, David; Sauerwein, Wolfgang; Angellier, Gaelle; Hérault, Joel; Caujolle, Jean-Pierre

    2016-01-01

    Purpose: In parapapillary melanoma patients, radiation-induced optic complications are frequent and visual acuity is often compromised. We investigated dose-effect relationships for the optic nerve with respect to visual acuity after proton therapy. Methods and Materials: Of 5205 patients treated between 1991 and 2014, those treated using computed tomography (CT)-based planning to 52 Gy (prescribed dose, not accounting for relative biologic effectiveness correction of 1.1) in 4 fractions, with minimal 6-month follow-up and documented initial and last visual acuity, were included. Deterioration of ≥0.3 logMAR between initial and last visual acuity results was reported. Results: A total of 865 consecutive patients were included. Median follow-up was 69 months, mean age was 61.7 years, tumor abutted the papilla in 35.1% of patients, and tumor-to-fovea distance was ≤3 mm in 74.2% of patients. Five-year relapse-free survival rate was 92.7%. Visual acuity was ≥20/200 in 72.6% of patients initially and 47.2% at last follow-up. A wedge filter was used in 47.8% of the patients, with a positive impact on vision and no impact on relapse. Glaucoma, radiation-induced optic neuropathy, maculopathy were reported in 17.9%, 47.5%, and 33.6% of patients, respectively. On multivariate analysis, age, diabetes, thickness, initial visual acuity and percentage of macula receiving 26 Gy were predictive of visual acuity. Furthermore, patients irradiated to ≥80% of their papilla had better visual acuity when limiting the 50% (30-Gy) and 20% (12-Gy) isodoses to ≤2 mm and 6 mm of optic nerve length, respectively. Conclusions: A personalized proton therapy plan with optic nerve and macular sparing can be used efficiently with good oncological and functional results in parapapillary melanoma patients.

  20. Visual Outcomes of Parapapillary Uveal Melanomas Following Proton Beam Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Thariat, Juliette, E-mail: jthariat@gmail.com [Department of Radiation Therapy, Cancer Center Antoine Lacassagne-Nice Sophia Antipolis University Hospital, Nice (France); Grange, Jean-Daniel [Department of Ophthalmology, Eye University Clinic la Croix Rousse, Lyon (France); Mosci, Carlo [Department of Ophthalmology, National Institute for Cancer Research, Mura Delle Cappucine, Genova (Italy); Rosier, Laurence [Eye Clinic, Centre d' Exploration et de Traitement de la Retine et de la Macula, Bordeaux (France); Maschi, Celia [Department of Ophthalmology, Eye University Clinic Pasteur 2, Nice (France); Lanza, Francesco [Department of Ophthalmology, National Institute for Cancer Research, Mura Delle Cappucine, Genova (Italy); Nguyen, Anh Minh [Department of Ophthalmology, Eye University Clinic la Croix Rousse, Lyon (France); Jaspart, Franck; Bacin, Franck; Bonnin, Nicolas [Department of Ophthalmology, Eye University Clinic Gabriel Montpied, Clermont Ferrand (France); Gaucher, David [Department of Ophthalmology, Eye University Clinic, Hopital Civil, Strasbourg (France); Sauerwein, Wolfgang [Department of Radiation Therapy, NCTeam, Strahlenklinik, Universitätsklinikum Essen, Essen (Germany); Angellier, Gaelle; Hérault, Joel [Department of Radiation Therapy, Cancer Center Antoine Lacassagne-Nice Sophia Antipolis University Hospital, Nice (France); Caujolle, Jean-Pierre [Department of Ophthalmology, Eye University Clinic Pasteur 2, Nice (France)

    2016-05-01

    Purpose: In parapapillary melanoma patients, radiation-induced optic complications are frequent and visual acuity is often compromised. We investigated dose-effect relationships for the optic nerve with respect to visual acuity after proton therapy. Methods and Materials: Of 5205 patients treated between 1991 and 2014, those treated using computed tomography (CT)-based planning to 52 Gy (prescribed dose, not accounting for relative biologic effectiveness correction of 1.1) in 4 fractions, with minimal 6-month follow-up and documented initial and last visual acuity, were included. Deterioration of ≥0.3 logMAR between initial and last visual acuity results was reported. Results: A total of 865 consecutive patients were included. Median follow-up was 69 months, mean age was 61.7 years, tumor abutted the papilla in 35.1% of patients, and tumor-to-fovea distance was ≤3 mm in 74.2% of patients. Five-year relapse-free survival rate was 92.7%. Visual acuity was ≥20/200 in 72.6% of patients initially and 47.2% at last follow-up. A wedge filter was used in 47.8% of the patients, with a positive impact on vision and no impact on relapse. Glaucoma, radiation-induced optic neuropathy, maculopathy were reported in 17.9%, 47.5%, and 33.6% of patients, respectively. On multivariate analysis, age, diabetes, thickness, initial visual acuity and percentage of macula receiving 26 Gy were predictive of visual acuity. Furthermore, patients irradiated to ≥80% of their papilla had better visual acuity when limiting the 50% (30-Gy) and 20% (12-Gy) isodoses to ≤2 mm and 6 mm of optic nerve length, respectively. Conclusions: A personalized proton therapy plan with optic nerve and macular sparing can be used efficiently with good oncological and functional results in parapapillary melanoma patients.

  1. Dosimetry of a prototype retractable eMLC for fixed-beam electron therapy

    International Nuclear Information System (INIS)

    Hogstrom, Kenneth R.; Boyd, Robert A.; Antolak, John A.; Svatos, Michelle M.; Faddegon, Bruce A.; Rosenman, Julian G.

    2004-01-01

    An electron multileaf collimator (eMLC) has been designed that is unique in that it retracts to 37 cm from the isocenter [63-cm source-to-collimator distance (SCD)] and can be deployed to distances of 20 and 10 cm from the isocenter (80 and 90 cm SCD, respectively). It is expected to be capable of arc therapy at 63 cm SCD; isocentric, fixed-beam therapy at 80 cm SCD; and source-to-surface distance (SSD), fixed-beam therapy at 90 cm SCD. In all positions, its leaves could be used for unmodulated or intensity-modulated therapy. Our goal in the present work is to describe the general characteristics of the eMLC and to demonstrate that its leakage characteristics and dosimetry are adequate for SSD, fixed-beam therapy as an alternative to Cerrobend cutouts with applicators once the prototype's leaves are motorized. Our eMLC data showed interleaf electron leakage at 15 MeV to be less than 0.1% based on a 0.0025 cm manufacturing tolerance, and lateral electron leakage at 5 and 15 MeV to be less than 2%. X-ray leakage through the leaves was 1.6% at 15 MeV. Our data showed that beam penumbra was independent of direction and leaf position. The dosimetric properties of square fields formed by the eMLC were very consistent with those formed by Cerrobend inserts in the 20x20 cm 2 applicator. Output factors exhibited similar field-size dependence. Airgap factors exhibited almost identical field-size dependence at two SSDs (105 and 110 cm), consistent with the common assumption that airgap factors are applicator independent. Percent depth-dose curves were similar, but showed variations up to 3% in the buildup region. The pencil-beam algorithm (PBA) fit measured data from the eMLC and applicator-cutout systems equally well, and the resulting two-dimensional (2-D) dose distributions, as predicted by the PBA, agreed well at common airgap distance. Simulating patient setups for breast and head and neck treatments showed that almost all fields could be treated using similar SSDs as

  2. A small electron beam ion trap/source facility for electron/neutral–ion collisional spectroscopy in astrophysical plasmas

    Science.gov (United States)

    Liang, Gui-Yun; Wei, Hui-Gang; Yuan, Da-Wei; Wang, Fei-Lu; Peng, Ji-Min; Zhong, Jia-Yong; Zhu, Xiao-Long; Schmidt, Mike; Zschornack, Günter; Ma, Xin-Wen; Zhao, Gang

    2018-01-01

    Spectra are fundamental observation data used for astronomical research, but understanding them strongly depends on theoretical models with many fundamental parameters from theoretical calculations. Different models give different insights for understanding a specific object. Hence, laboratory benchmarks for these theoretical models become necessary. An electron beam ion trap is an ideal facility for spectroscopic benchmarks due to its similar conditions of electron density and temperature compared to astrophysical plasmas in stellar coronae, supernova remnants and so on. In this paper, we will describe the performance of a small electron beam ion trap/source facility installed at National Astronomical Observatories, Chinese Academy of Sciences.We present some preliminary experimental results on X-ray emission, ion production, the ionization process of trapped ions as well as the effects of charge exchange on the ionization.

  3. Design Study of a 100 GeV Beam Transfer Line from the SPS for a Short Baseline Neutrino Facility

    CERN Document Server

    Bartmann, W; Kosmicki, A; Kowalska, M; Velotti, F

    2013-01-01

    A short baseline neutrino facility at CERN is presently under study. It is considered to extract a 100 GeV beam from the second long straight section of the SPS into the existing transfer channel TT20, which leads to the North Area experimental zone. A new transfer line would branch off the existing TT20 line around 600 m downstream of the extraction, followed by an S-shaped horizontal bending arc to direct the beam with the correct angle onto the defined target location. This paper describes the optimisation of the line geometry with respect to the switch regions in TT20, the integration into the existing facilities and the potential refurbishment of existing magnets. The optics design is shown, and the requirements for the magnets, power converters and instrumentation hardware are discussed.

  4. Fast heating of a dense plasma by high-power electron beam at the GOL-3-II facility

    International Nuclear Information System (INIS)

    Arzhannikov, A.V.; Astrelin, V.T.; Burdakov, A.V.; Koidan, V.S.; Mekler, K.I.; Melnikov, P.I.; Polosatkin, S.V.; Postupaev, V.V.; Rovenskikh, A.F.; Sinitsky, S.L.

    2001-01-01

    Recent results on dense plasma heating by 200 kJ-electron beam at GOL-3-II facility are presented. The efficiency of collective electron beam deceleration up to 40% is achieved in 10 15 cm -3 plasma. The characteristic electron temperature of ∼2 keV at plasma density (1-2)x10 15 cm -3 is obtained. At the two-stage heating of a dense (∼10 16 cm -3 ) plasma the electron temperature of 300-500 eV and the ion temperature of 100-200 eV are reached. Prospects of experiments on 'wall' and multimirror plasma confinement at GOL-3-II facility are discussed. (author)

  5. Secondary Beam Monitors for the NuMI Facility at FNAL

    Energy Technology Data Exchange (ETDEWEB)

    Indurthy, Dharmaraj [Texas U.

    2006-01-01

    The Neutrinos at the Main Injector (NuMI) beam principally supplies high energy neutrinos to the Main Injector Neutrino Oscillation Search (MINOS) experiment, which is investigating neutrino oscillations. The NuMI beamline accepts 120 GeV protons from the Fermilab Main Injector and steers them toward a graphite target to produce a secondary meson beam that decays to neutrinos and muons. Due to the constraints placed on beam quality, ionization chamber arrays are developed to measure the primary beam and tertiary charged particles to monitor beam quality, beam direction, and the operational integrity of the upstream beamline components. This thesis describes the research and development of these beam monitors and their demonstrated utility for MINOS and NuMI.

  6. The evaluation of properties for radiation therapy techniques with flattening filter-free beam and usefulness of time and economy to a patient with the radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Goo, Jang Hyeon; Won, Hui Su; Hong, Joo Wan; Chang, Nam Jun; Park, Jin Hong [Dept. of Radiation Oncology, Seoul national university Bundang hospital, Sungnam (Korea, Republic of)

    2014-12-15

    The aim of this study was to appraise properties for radiation therapy techniques and effectiveness of time and economy to a patient in the case of applying flattening filter-free (3F) and flattening filter (2F) beam to the radiation therapy. Alderson rando phantom was scanned for computed tomography image. Treatment plans for intensity modulated radiation therapy (IMRT), volumetric modulated arc therapy (VMAT) and stereotactic body radiation therapy (SBRT) with 3F and 2F beam were designed for prostate cancer. To evaluate the differences between the 3F and 2F beam, total monitor units (MUs), beam on time (BOT) and gantry rotation time (GRT) were used and measured with TrueBeam{sup TM} STx and Surveillance And Measurement (SAM) 940 detector was used for photoneutron emitted by using 3F and 2F. To assess temporal and economical aspect for a patient, total treatment periods and medical fees were estimated. In using 3F beam, total MUs in IMRT plan increased the highest up to 34.0% and in the test of BOT, GRT and photoneutron, the values in SBRT plan decreased the lowest 39.8, 38.6 and 48.1%, respectively. In the temporal and economical aspect, there were no differences between 3F and 2F beam in all of plans and the results showed that 10 days and 169,560 won was lowest in SBRT plan. According as the results, total MUs increased by using 3F beam than 2F beam but BOT, GRT and photoneutron decreased. From above the results, using 3F beam can decrease intra-fraction setup error and risk of radiation-induced secondary malignancy. But, using 3F beam did not make the benefits of temporal and economical aspect for a patient with the radiation therapy.

  7. LICORNE: A new and unique facility for producing intense, kinematically focused neutron beams at the IPN Orsay

    Directory of Open Access Journals (Sweden)

    Wilson J.N.

    2013-12-01

    Full Text Available LICORNE is a new neutron source recently installed at the tandem accelerator of the Institut de Physique Nucléaire d'Orsay, where a Li7-beam is used to bombard a hydrogen-containing target to produce an intense forward-directed neutron beam. The directionality of the beam, which is the unique characteristic of LICORNE, will permit the installation of γ-ray detectors dedicated to the investigation of fission fragment de-excitation which are unimpeded by neutrons from the source. A first experimental program will focus on the measurement of prompt γ-ray emission in the neutron-induced fission of fertile and fissile isotopes at incident neutron energies relevant for the core design of Generation-IV nuclear reactors. Other potential uses of the LICORNE facility for both fundamental and applied physics research are also presented.

  8. Performance of a liquid argon time projection chamber exposed to the CERN West Area Neutrino Facility neutrino beam

    International Nuclear Information System (INIS)

    Arneodo, F.; Cavanna, F.; Mitri, I. De; Mortari, G. Piano; Benetti, P.; Borio di Tigliole, A.; Calligarich, E.; Cesana, E.; Dolfini, R.; Mauri, F.; Montanari, C.; Rappoldi, A.; Raselli, G. L.; Rubbia, C.; Terrani, M.; Vignoli, C.; Bonesini, M.; Boschetti, B.; Cavalli, D.; Curioni, A.

    2006-01-01

    We present the results of the first exposure of a Liquid Argon TPC to a multi-GeV neutrino beam. The data have been collected with a 50 liters ICARUS-like chamber located between the CHORUS and NOMAD experiments at the CERN West Area Neutrino Facility (WANF). We discuss both the instrumental performance of the detector and its capability to identify and reconstruct low-multiplicity neutrino interactions

  9. A new small-footprint external-beam PIXE facility for cultural heritage applications using pulsed proton beams

    Science.gov (United States)

    Vadrucci, M.; Bazzano, G.; Borgognoni, F.; Chiari, M.; Mazzinghi, A.; Picardi, L.; Ronsivalle, C.; Ruberto, C.; Taccetti, F.

    2017-09-01

    In the framework of the COBRA project, elemental analyses of cultural heritage objects based on the particle induced X-ray emission (PIXE) are planned in a collaboration between the APAM laboratory of ENEA-Frascati and the LABEC laboratory of INFN in Florence. With this aim a 3-7 MeV pulsed proton beam, driven by the injector of the protontherapy accelerator under construction for the TOP-IMPLART project, will be used to demonstrate the feasibility of the technique with a small-footprint pulsed accelerator to Italian small and medium enterprises interested in the composition analysis of ancient artifacts. The experimental set-up for PIXE analysis on the TOP-IMPLART machine consists of a modified assembly of the vertical beam line usually dedicated to radiobiology experiments: the beam produced by the injector (RFQ + DTL, a PL7 ACCSYSHITACHI model) is bent to 90° by a magnet, is collimated by a 300 μm aperture inserted in the end nozzle and extracted into ambient pressure by an exit window consisting of a Upilex foil 7.5 μm thick. The beam is pulsed with a variable pulse duration of 20-100 μs and a repetition rate variable from 10 to 100 Hz. The X-ray detection system is based on a Ketek Silicon Drift Detector (SDD) with 7 mm2 active area and 450 μm thickness, with a thin Beryllium entrance window (8 μm). The results of the calibration of this new PIXE set-up using thick target standards and of the analysis of the preliminary measurements on pigments are presented.

  10. External-beam radiation therapy after surgical resection and intraoperative electron-beam radiation therapy for oligorecurrent gynecological cancer. Long-term outcome

    Energy Technology Data Exchange (ETDEWEB)

    Sole, C.V. [Hospital General Universitario Gregorio Maranon, Department of Oncology, Madrid (Spain); Complutense University, School of Medicine, Madrid (Spain); Instituto de Radiomedicina, Service of Radiation Oncology, Santiago (Chile); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Calvo, F.A. [Hospital General Universitario Gregorio Maranon, Department of Oncology, Madrid (Spain); Complutense University, School of Medicine, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Lozano, M.A.; Gonzalez-Sansegundo, C. [Hospital General Universitario Gregorio Maranon, Department of Oncology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Service of Radiation Oncology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Gonzalez-Bayon, L. [Hospital General Universitario Gregorio Maranon, Service of General Surgery, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Alvarez, A. [Hospital General Universitario Gregorio Maranon, Service of Radiation Oncology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Lizarraga, S. [Hospital General Universitario Gregorio Maranon, Department of Gynecology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Garcia-Sabrido, J.L. [Complutense University, School of Medicine, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Service of General Surgery, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Department of Gynecology, Madrid (Spain)

    2014-02-15

    The goal of the present study was to analyze prognostic factors in patients treated with external-beam radiation therapy (EBRT), surgical resection and intraoperative electron-beam radiotherapy (IOERT) for oligorecurrent gynecological cancer (ORGC). From January 1995 to December 2012, 61 patients with ORGC [uterine cervix (52 %), endometrial (30 %), ovarian (15 %), vagina (3 %)] underwent IOERT (12.5 Gy, range 10-15 Gy), and surgical resection to the pelvic (57 %) and paraaortic (43 %) recurrence tumor bed. In addition, 29 patients (48 %) also received EBRT (range 30.6-50.4 Gy). Survival outcomes were estimated using the Kaplan-Meier method, and risk factors were identified by univariate and multivariate analyses. Median follow-up time for the entire cohort of patients was 42 months (range 2-169 months). The 10-year rates for overall survival (OS) and locoregional control (LRC) were 17 and 65 %, respectively. On multivariate analysis, no tumor fragmentation (HR 0.22; p = 0.03), time interval from primary tumor diagnosis to locoregional recurrence (LRR) < 24 months (HR 4.02; p = 0.02) and no EBRT at the time of pelvic recurrence (HR 3.95; p = 0.02) retained significance with regard to LRR. Time interval from primary tumor to LRR < 24 months (HR 2.32; p = 0.02) and no EBRT at the time of pelvic recurrence (HR 3.77; p = 0.04) showed a significant association with OS after adjustment for other covariates. External-beam radiation therapy at the time of pelvic recurrence, time interval for relapse ≥24 months and not multi-involved fragmented resection specimens are associated with improved LRC in patients with ORGC. As suggested from the present analysis a significant group of ORGC patients could potentially benefit from multimodality rescue treatment. (orig.)

  11. External-beam radiation therapy after surgical resection and intraoperative electron-beam radiation therapy for oligorecurrent gynecological cancer. Long-term outcome

    International Nuclear Information System (INIS)

    Sole, C.V.; Calvo, F.A.; Lozano, M.A.; Gonzalez-Sansegundo, C.; Gonzalez-Bayon, L.; Alvarez, A.; Lizarraga, S.; Garcia-Sabrido, J.L.

    2014-01-01

    The goal of the present study was to analyze prognostic factors in patients treated with external-beam radiation therapy (EBRT), surgical resection and intraoperative electron-beam radiotherapy (IOERT) for oligorecurrent gynecological cancer (ORGC). From January 1995 to December 2012, 61 patients with ORGC [uterine cervix (52 %), endometrial (30 %), ovarian (15 %), vagina (3 %)] underwent IOERT (12.5 Gy, range 10-15 Gy), and surgical resection to the pelvic (57 %) and paraaortic (43 %) recurrence tumor bed. In addition, 29 patients (48 %) also received EBRT (range 30.6-50.4 Gy). Survival outcomes were estimated using the Kaplan-Meier method, and risk factors were identified by univariate and multivariate analyses. Median follow-up time for the entire cohort of patients was 42 months (range 2-169 months). The 10-year rates for overall survival (OS) and locoregional control (LRC) were 17 and 65 %, respectively. On multivariate analysis, no tumor fragmentation (HR 0.22; p = 0.03), time interval from primary tumor diagnosis to locoregional recurrence (LRR) < 24 months (HR 4.02; p = 0.02) and no EBRT at the time of pelvic recurrence (HR 3.95; p = 0.02) retained significance with regard to LRR. Time interval from primary tumor to LRR < 24 months (HR 2.32; p = 0.02) and no EBRT at the time of pelvic recurrence (HR 3.77; p = 0.04) showed a significant association with OS after adjustment for other covariates. External-beam radiation therapy at the time of pelvic recurrence, time interval for relapse ≥24 months and not multi-involved fragmented resection specimens are associated with improved LRC in patients with ORGC. As suggested from the present analysis a significant group of ORGC patients could potentially benefit from multimodality rescue treatment. (orig.)

  12. Treatment planning, optimization, and beam delivery technqiues for intensity modulated proton therapy

    Science.gov (United States)

    Sengbusch, Evan R.

    Physical properties of proton interactions in matter give them a theoretical advantage over photons in radiation therapy for cancer treatment, but they are seldom used relative to photons. The primary barriers to wider acceptance of proton therapy are the technical feasibility, size, and price of proton therapy systems. Several aspects of the proton therapy landscape are investigated, and new techniques for treatment planning, optimization, and beam delivery are presented. The results of these investigations suggest a means by which proton therapy can be delivered more efficiently, effectively, and to a much larger proportion of eligible patients. An analysis of the existing proton therapy market was performed. Personal interviews with over 30 radiation oncology leaders were conducted with regard to the current and future use of proton therapy. In addition, global proton therapy market projections are presented. The results of these investigations serve as motivation and guidance for the subsequent development of treatment system designs and treatment planning, optimization, and beam delivery methods. A major factor impacting the size and cost of proton treatment systems is the maximum energy of the accelerator. Historically, 250 MeV has been the accepted value, but there is minimal quantitative evidence in the literature that supports this standard. A retrospective study of 100 patients is presented that quantifies the maximum proton kinetic energy requirements for cancer treatment, and the impact of those results with regard to treatment system size, cost, and neutron production is discussed. This study is subsequently expanded to include 100 cranial stereotactic radiosurgery (SRS) patients, and the results are discussed in the context of a proposed dedicated proton SRS treatment system. Finally, novel proton therapy optimization and delivery techniques are presented. Algorithms are developed that optimize treatment plans over beam angle, spot size, spot spacing

  13. BEAM DYNAMICS STUDIES FOR A COMPACT CARBON ION LINAC FOR THERAPY

    Energy Technology Data Exchange (ETDEWEB)

    Plastun, A.; Mustapha, B.; Nassiri, A.; Ostroumov, P.

    2016-05-01

    Feasibility of an Advanced Compact Carbon Ion Linac (ACCIL) for hadron therapy is being studied at Argonne National Laboratory in collaboration with RadiaBeam Technologies. The 45-meter long linac is designed to deliver 109 carbon ions per second with variable energy from 45 MeV/u to 450 MeV/u. S-band structure provides the acceleration in this range. The carbon beam energy can be adjusted from pulse to pulse, making 3D tumor scanning straightforward and fast. Front end accelerating structures such as RFQ, DTL and coupled DTL are designed to operate at lower frequencies. The design of the linac was accompanied with extensive end-to-end beam dynamics studies which are presented in this paper.

  14. Clinical trial of cancer therapy with heavy ions at heavy ion research facility in lanzhou

    Science.gov (United States)

    Zhang, Hong

    With collaborative efforts of scientists from the Institute of Modern Physics (IMP), Chinese Academy of Sciences and hospitals in Gansu, initial clinical trial on cancer therapy with heavy ions has been successfully carried out in China. From November 2006 to December 2007, 51 patients with superficially-placed tumors were treated with carbon ions at Heavy Ion Research Facility in Lanzhou (HIRFL) within four beam time blocks of 6-11 days, collaborating with the General Hospital of Lanzhou Command and the Tumor Hospital of Gansu Province. Patients and Methods: There were 51 patients (31 males and 20 females) with superficially-placed tumors (squamous cell carcinoma of the skin, basal cell carcinoma of the skin, malignant skin melanoma, sarcoma, lymphoma, breast cancer, metastatic lymph nodes of carcinomas and other skin lesions). The tumors were less than 2.1 cm deep to the skin surface. All patients had histological confirmation of their tumors. Karnofsky Performance Scale (KPS) of all patients was more than 70. The majority of patients were with failures or recurrences of conventional therapies. Median age at the time of radiotherapy (RT) was 55.5 years (range 5-85 years). Patients were immobilized with a vacuum cushion or a head mask and irradiated by carbon ion beams with energy 80-100 MeV/u at spread-out Bragg peak field generated from HIRFL, with two and three-dimensional conformal irradiation methods. Target volume was defined by physical palpation [ultrasonography and Computerized tomography (CT), for some cases]. The clinical target volume (CTV) was defined as the gross total volume GTV with a 0.5-1.0cm margin axially. Field placement for radiation treatment planning was done based on the surface markings. RBE of 2.5-3 within the target volume, and 40-75 GyE with a weekly fractionation of 7 × 3-15 GyE/fraction were used in the trial. Patients had follow-up examinations performed 1 month after treatment, in 1 or 2 months for the first 6 months, and 3

  15. Initial clinical evaluation of PET-based ion beam therapy monitoring under consideration of organ motion.

    Science.gov (United States)

    Kurz, Christopher; Bauer, Julia; Unholtz, Daniel; Richter, Daniel; Herfarth, Klaus; Debus, Jürgen; Parodi, Katia

    2016-02-01

    Intrafractional organ motion imposes considerable challenges to scanned ion beam therapy and demands for a thorough verification of the applied treatment. At the Heidelberg Ion-Beam Therapy Center (HIT), the scanned ion beam delivery is verified by means of postirradiation positron-emission-tomography (PET) imaging. This work presents a first clinical evaluation of PET-based treatment monitoring in ion beam therapy under consideration of target motion. Three patients with mobile liver lesions underwent scanned carbon ion irradiation at HIT and postirradiation PET/CT (x-ray-computed-tomography) imaging with a commercial scanner. Respiratory motion was recorded during irradiation and subsequent image acquisition. This enabled a time-resolved (4D) calculation of the expected irradiation-induced activity pattern and, for one patient where an additional 4D CT was acquired at the PET/CT scanner after treatment, a motion-compensated PET image reconstruction. For the other patients, PET data were reconstructed statically. To verify the treatment, calculated prediction and reconstructed measurement were compared with a focus on the ion beam range. Results in the current three patients suggest that for motion amplitudes in the order of 2 mm there is no benefit from incorporating respiratory motion information into PET-based treatment monitoring. For a target motion in the order of 10 mm, motion-related effects become more severe and a time-resolved modeling of the expected activity distribution can lead to an improved data interpretation if a sufficient number of true coincidences is detected. Benefits from motion-compensated PET image reconstruction could not be shown conclusively at the current stage. The feasibility of clinical PET-based treatment verification under consideration of organ motion has been shown for the first time. Improvements in noise-robust 4D PET image reconstruction are deemed necessary to enhance the clinical potential.

  16. Laser-Driven Very High Energy Electron/Photon Beam Radiation Therapy in Conjunction with a Robotic System

    Directory of Open Access Journals (Sweden)

    Kazuhisa Nakajima

    2014-12-01

    Full Text Available We present a new external-beam radiation therapy system using very-high-energy (VHE electron/photon beams generated by a centimeter-scale laser plasma accelerator built in a robotic system. Most types of external-beam radiation therapy are delivered using a machine called a medical linear accelerator driven by radio frequency (RF power amplifiers, producing electron beams with an energy range of 6–20 MeV, in conjunction with modern radiation therapy technologies for effective shaping of three-dimensional dose distributions and spatially accurate dose delivery with imaging verification. However, the limited penetration depth and low quality of the transverse penumbra at such electron beams delivered from the present RF linear accelerators prevent the implementation of advanced modalities in current cancer treatments. These drawbacks can be overcome if the electron energy is increased to above 50 MeV. To overcome the disadvantages of the present RF-based medical accelerators, harnessing recent advancement of laser-driven plasma accelerators capable of producing 1-GeV electron beams in a 1-cm gas cell, we propose a new embodiment of the external-beam radiation therapy robotic system delivering very high-energy electron/photon beams with an energy of 50–250 MeV; it is more compact, less expensive, and has a simpler operation and higher performance in comparison with the current radiation therapy system.

  17. Proton therapy treatment monitoring with in-beam PET: Investigating space and time activity distributions

    Science.gov (United States)

    Brombal, L.; Barbosa, D.; Belcari, N.; Bisogni, M. G.; Camarlinghi, N.; Cristoforetti, L.; Guerra, A. Del; Fracchiolla, F.; Morrocchi, M.; Sportelli, G.; Righetto, R.; Schwarz, M.; Topi, A.; Rosso, V.

    2017-07-01

    In this study the possibility of retrieving composition information in proton therapy with a planar in-beam PET scanner is investigated. The analysis focuses both on spatial activity distributions and time dependence of the recorded signal. The experimental data taking was performed at the Trento Proton Therapy Center (IT) by irradiating three different phantoms. We show that different phantom compositions reflect into different activity profile shapes. We demonstrate that the analysis of the event rate can provide significant information on the phantom elemental composition, suggesting that elemental analysis could be used along with activity profile analysis to achieve a more accurate treatment monitoring.

  18. Evaluation of a GEM and CAT-based detector for radiation therapy beam monitoring

    International Nuclear Information System (INIS)

    Brahme, A.; Danielsson, M.; Iacobaeus, C.; Ostling, J.; Peskov, V.; Wallmark, M.

    2000-01-01

    We are developing a radiation therapy beam monitor for the Karolinska Institute. This monitor will consist of two consecutive detectors confined in one gas chamber: a 'keV-photon detector', which will allow diagnostic quality visualization of the patient, and a 'MeV-photon detector', that will measure the absolute intensity of the therapy beam and its position with respect to the patient. Both detectors are based on highly radiation resistant gas and solid photon to electron converters, combined with GEMs and a CAT as amplification structures. We have performed systematic studies of the high-rate characteristics of the GEM and the CAT, as well as tested the electron transfer through these electron multipliers and various types of converters. The tests show that the GEM and the CAT satisfy all requirements for the beam monitoring system. As a result of these studies we successfully developed and tested a full section of the beam monitor equipped with a MeV-photon converter placed between the GEM and the CAT

  19. Automated analysis of PET based in-vivo monitoring in ion beam therapy

    International Nuclear Information System (INIS)

    Kuess, P.

    2014-01-01

    Particle Therapy (PT)-PET is currently the only clinically approved in-vivo method for monitoring PT. Due to fragmentation processes in the patients' tissue and the beam projectiles, a beta plus activity distribution (BAD) can be measured during or shortly after the irradiation. The recorded activity map can not be directly compared to the planned dose distribution. However, by means of a Monte Carlo (MC) simulation it is possible to predict the measured BAD from a treatment plan (TP). Thus to verify a patient's treatment fraction the actual PET measurement can be compared to the respective BAD prediction. This comparison is currently performed by visual inspection which requires experienced evaluators and is rather time consuming. In this PhD thesis an evaluation tool is presented to compare BADs in an automated and objective way. The evaluation method was based on the Pearson's correlation coefficient (PCC) – an established measure in medical image processing – which was coded into a software tool. The patient data used to develop, test and validate the software tool were acquired at the GSI research facility where over 400 patient treatments with 12C were monitored by means of an in-beam PET prototype. The number of data sets was increased by artificially altering BAD to simulate different beam ranges. The automated detection tool was tested in head and neck (H&N), prostate, lung, and brain. To generate carbon ion TPs the treatment planning system TRiP98 was used for all cases. From these TPs the respective BAD predictions were derived. Besides the detection of range deviations by means of PT-PET also the automated detection of patient setup uncertainties was investigated. Although all measured patient data were recorded during the irradiation (in-beam) also scenarios performing PET scans shortly after the irradiation (in-room) were considered. To analyze the achievable precision of PT-PET with the automated evaluation tool based on

  20. The design and performance of the FNAL high-energy polarized beam facility

    International Nuclear Information System (INIS)

    Tanaka, Nobuyuki.

    1989-01-01

    We describe a new polarized-proton and -antiproton beam with 185-GeV/c momentum in the Fermilab MP beam line which is currently operational. The design uses the parity-conserving decay of lambda and antilambda hyperons to produce polarized protons and antiprotons, respectively. A beam-transport system minimizes depolarization effects and uses a set of 12 dipole magnets that rotate the beam-particle spin direction. A beam-tagging system determines the momentum and polarization of individual beam particles, allowing a selection of particles in definite intervals at momentum and polarization. We measured polarization of the beam by using two types of polarimeters, which verified the determination of polarization by a beam-particle tagging system. Two of these processes are the inverse-Primakoff effect and the Coulomb-nuclear interference (CNI) in elastic proton-proton scattering. Another experiment measured the π 0 production asymmetry of large-x F values; this process may now be used as an on-line beam polarimeter. 9 refs., 9 figs

  1. Steps Towards a 3 mA, 1.8 MW Proton Beam at the PSI Cyclotron Facility

    CERN Document Server

    Schmelzbach, Pierre A; Adelmann, Andreas; Fitze, Hansruedi; Heidenreich, Gerd; Raguin, Jean-Yves; Rohrer, Urs; Sigg, Peter K

    2005-01-01

    The PSI Cyclotron Facility produces routinely a 1.8-1.9 mA proton beam at 590 MeV. The beam power reaches 1.1 MW at the the pion production targets and 0.7 MW at the neutron spallation target SINQ. The accelerator complex will be analysed in respect to his potential for future improvements. The ongoing developments aiming to increase the beam intensity to 3 mA and hence the beam power to 1.8 MW will be discussed. Smooth extrapolations of the observed machine parameters as well as recent advances in the theoretical treatment of space charge dominated beams show that this goal can be achieved with available technologies. IA new RF-cavity operated at a voltage in excess of 1 MV has been successfully tested and installed in the Ring Cyclotron. Bunchers for the low energy and the medium energy transfer lines are in the design phase. A conceptual study of new accelerating cavities to replace the obsolete flattop-cavities of the Injector Cyclotron has been performed. While the upgrade of the Ring Cyclotron with four...

  2. The dosimetric Properties of Electron Beam Using Lyon Intraoperative Device for Intraoperative Radiation Therapy

    International Nuclear Information System (INIS)

    Kim, Kye Jun; Park, Kyung Ran; Lee, Jong Young; Kim, Hie Yeon; Sung, Ki Joon; Chu, Sung Sil

    1992-01-01

    We have studied the dosimetric properties of electron beam using Lyon intraoperative device for intraoperative radiation therapy. The dosimetry data had compiled in such a way that a quick and correct decision regarding the cone shape, energy, and accurate calculations could be made. Using 3 dimensional water phantom, we have got the following data: cone output ratios, surface dose, dmax, dgo, flatness, symmetry, beam profiles, isodose curve, and SSD correction factors. The cone output ratios were measured with straight and bevelled cone, respectively. As the cone size and the energy were reduced, the cone output ratios decreased rapidly. With the flattening filter, the surface dose increased by electron beam to 85.3%, 89.2%, and 93.4%, for 6MeV, 9MeV, and 12MeV, respectively. It is important to increase the surface dose to 90% or more. Inspite of diminishing dose rate and beam penetration, this flattening filter increases the treatment volume significantly. With the combination of the three levels collimation and the flattening filter, we achieved good homogeneity of the beam and better flatness and the diameter of the 90% isodose curve was increased. It is important to increase the area that is included in the 90% isodose level. The value of measured and calculated SSD correction factors did not agree over the clinically important range from 100 cm to 110 cm

  3. A novel beam optics concept in a particle therapy gantry utilizing the advantages of superconducting magnets

    International Nuclear Information System (INIS)

    Gerbershagen, Alexander; Meer, David; Schippers, Jacobus Maarten; Seidel, Mike

    2016-01-01

    A first order design of the beam optics of a superconducting proton therapy gantry beam is presented. The possibilities of superconducting magnets with respect to the beam optics such as strong fields, large apertures and superposition of different multipole fields have been exploited for novel concepts in a gantry. Since various techniques used in existing gantries have been used in our first design steps, some examples of the existing superconducting gantry designs are described and the necessary requirements of such a gantry are explained. The study of a gantry beam optics design is based on superconducting combined function magnets. The simulations have been performed in first order with the conventional beam transport codes. The superposition of strong dipole and quadrupole fields generated by superconducting magnets enables the introduction of locally achromatic bending sections without increasing the gantry size. A rigorous implementation of such beam optics concepts into the proposed gantry design dramatically increases the momentum acceptance compared to gantries with normal conducting magnets. In our design this large acceptance has been exploited by the implementation of a degrader within the gantry and a potential possibility to use the same magnetic field for all energies used in a treatment, so that the superconducting magnets do not have to vary their fields during a treatment. This also enables very fast beam energy changes, which is beneficial for spreading the Bragg peak over the thickness of the tumor. The results show an improvement of its momentum acceptance. Large momentum acceptance in the gantry creates a possibility to implement faster dose application techniques.

  4. A novel beam optics concept in a particle therapy gantry utilizing the advantages of superconducting magnets

    Energy Technology Data Exchange (ETDEWEB)

    Gerbershagen, Alexander; Meer, David; Schippers, Jacobus Maarten; Seidel, Mike [Paul Scherrer Institut (PSI), Villigen (Switzerland)

    2016-11-01

    A first order design of the beam optics of a superconducting proton therapy gantry beam is presented. The possibilities of superconducting magnets with respect to the beam optics such as strong fields, large apertures and superposition of different multipole fields have been exploited for novel concepts in a gantry. Since various techniques used in existing gantries have been used in our first design steps, some examples of the existing superconducting gantry designs are described and the necessary requirements of such a gantry are explained. The study of a gantry beam optics design is based on superconducting combined function magnets. The simulations have been performed in first order with the conventional beam transport codes. The superposition of strong dipole and quadrupole fields generated by superconducting magnets enables the introduction of locally achromatic bending sections without increasing the gantry size. A rigorous implementation of such beam optics concepts into the proposed gantry design dramatically increases the momentum acceptance compared to gantries with normal conducting magnets. In our design this large acceptance has been exploited by the implementation of a degrader within the gantry and a potential possibility to use the same magnetic field for all energies used in a treatment, so that the superconducting magnets do not have to vary their fields during a treatment. This also enables very fast beam energy changes, which is beneficial for spreading the Bragg peak over the thickness of the tumor. The results show an improvement of its momentum acceptance. Large momentum acceptance in the gantry creates a possibility to implement faster dose application techniques.

  5. The Rapid Cycling Synchrotron of the EURISOL Beta-Beam facility

    CERN Document Server

    Lachaize, A

    During the last two years, several upgrades of the initial baseline scenario were studied with the aim of increasing the average intensity of ion beams in the accelerator chain of the Beta Beam complex. This is the reason why the Rapid Cycling Synchrotron (RCS) specifications were reconsidered many times.General considerations on the optical design were presented at the Beta Beam Task Meetings held at CERN and at Saclay in 2005 (http://beta-beam.web.cern.ch/beta-beam/). More detailed beam optics studies were performed during the next months. Lattices, RF system parameters, multi-turn injection scheme, fast extraction, closed orbit correction and chromaticity correction systems were proposed for different versions of the RCS.Finally, the RCS specifications have stabilized in November 2006 after the fourth Beta Beam Task Meeting when it was decided to fix the maximum magnetic rigidity of ion beams to 14.47 T.m (3.5 GeV equivalent proton energy) and to adopt a ring physical radius of 40 m in order to facilitat...

  6. Stabilization of the Beam Intensity in the Linac at the CTF3 CLIC Test Facility

    CERN Document Server

    Dubrovskiy, A; Bathe, BN; Srivastava, S

    2013-01-01

    A new electron beam stabilization system has been introduced in CTF3 in order to open new possibilities for CLIC beam studies in ultra-stable conditions and to provide a sustainable tool to keep the beam intensity and energy at its reference values for long term operations. The stabilization system is based on a pulse-to-pulse feedback control of the electron gun to compensate intensity deviations measured at the end of the injector and at the beginning of the linac. Thereby it introduces negligible beam distortions at the end of the linac and it significantly reduces energy deviations. A self-calibration mechanism has been developed to automatically configure the feedback controller for the optimum performance. The residual intensity jitter of 0.045% of the stabilized beam was measured whereas the CLIC requirement is 0.075%.

  7. Application of the electron pencil beam redefinition algorithm to electron arc therapy.

    Science.gov (United States)

    Chi, Pai-Chun M; Hogstrom, Kenneth R; Starkschall, George; Boyd, Robert A; Tucker, Susan L; Antolak, John A

    2006-07-01

    This project investigated the potential of summing fixed-beam dose distributions calculated using the pencil-beam redefinition algorithm (PBRA) at small angular steps (1 degree) to model an electron arc therapy beam. The PRBA, previously modified to model skin collimation, was modified further by incorporating two correction factors. One correction factor that is energy, SSD (source-to-surface distance), and field-width dependent constrained the calculated dose output to be the same as the measured dose output for fixed-beam geometries within the range of field widths and SSDs encountered in arc therapy. Another correction factor (single field-width correction factor for each energy) compensated for large-angle scattering not being modeled, allowing a more accurate calculation of dose output at mid arc. The PBRA was commissioned to accurately calculate dose in a water phantom for fixed-beam geometries typical of electron arc therapy. Calculated central-axis depth doses agreed with measured doses to within 2% in the low-dose gradient regions and within 1-mm in the high-dose gradient regions. Off-axis doses agreed to within 2 mm in the high-dose gradient regions and within 3% in the low-dose gradient regions. Arced-beam calculations of dose output and depth dose at mid arc were evaluated by comparing to data measured using two cylindrical water phantoms with radii of 12 and 15 cm at 10 and 15 MeV. Dose output was measured for all combinations of phantom radii of curvature, collimator widths (4, 5, and 6 cm), and arc angles (0 degrees, 20 degrees, 40 degrees, 60 degrees, 80 degrees, and 90 degrees) for both beam energies. Results showed the calculated mid-arc dose output to agree within 2% of measurement for all combinations. For a 90 degree arc angle and 5 x 20 cm2 field size, the calculated mid-arc depth dose in the low-dose gradient region agreed to within 2% of measurement for all depths at 10 MeV and for depths greater than depth of dose maximum R100 at 15 Me

  8. The earthing system of the PRIMA Neutral Beam Test Facility based on the Mesh Common Bonding Network topology

    International Nuclear Information System (INIS)

    Pomaro, Nicola; Boldrin, Marco; Lazzaro, Gabriele

    2015-01-01

    Highlights: • We designed a high performance earthing system for the ITER Neutral Beam Test Facility. • The system is based on the Mesh Common Bonded Network topology. • Careful bonding of all metallic structures allowed to obtain a well meshed system. • Special care was dedicated to improve EMC performance of critical areas like control rooms. • The facility experimental results will be representative also of the ITER situation. - Abstract: PRIMA is a large experimental facility under realization in Padova, aimed at developing and testing the Neutral Beam Injectors for ITER. The operation of these devices involves high RF power and voltage up to 1 MV. Frequent and high voltage electrical breakdowns inside the beam sources occur regularly. The presence of a distributed carefully optimized earthing system is of paramount importance to achieve a satisfying disturbances immunity for equipment and diagnostics. The paper describes the design and the realization of the earthing system of the PRIMA facility, which is based on the MESH-Common Bonding Network (MESH-CBN) topology, as recommended by IEC and IEEE standards for installations with high levels of Electromagnetic Interferences (EMI). The principles of the MESH-CBN approach were adapted to the PRIMA layout, which is composed by several buildings, that are independent for seismic and architectural reasons, but are linked by many electrical conduits and hydraulic pipelines. The availability of huge foundations, with a large number of poles and pillars, was taken into account; building parts dedicated to host control rooms and sensitive equipment were treated with particular care. Moreover, the lightning protection system was integrated and harmonized with the earthing system.

  9. A Study on clinical Considerations caused by inevitably Extended SSD for Electron beam therapy

    International Nuclear Information System (INIS)

    Lee, Jung Woo; Kim, Jeong Man

    1996-01-01

    We are often faced with the clinical situations that is inevitably extended SSD for electron beam therapy due to anatomical restriction or applicator structure. But there are some difficulties in accurately predicting output and properties. In electron beam treatment , unlike photon beam the decrease in output for extended SSD does not follow inverse-square law accurately because of a loss of side scatter equilibrium, which is particularly significant for small cone size and low energies. The purpose of our study is to analyze the output in changing with the energy, cone size, air gap beyond the standard SSD and to compare inverse-square law factor derived from calculated effective SSD, mominal SSD with measured output factor. In addition, we have analyzed the change of PDD for several cones with different SSDs which range from 100 cm to 120 cm with 5 cm step and with different energies(6 MeV, 9 MeV, 12 MeV, 16 MeV, 20 MeV). In accordance with our study, an extended SSD produces a significant change in beam output, negligible change in depth dose which range from 100 cm to 120 cm SSDs. In order to deliver the more accurate dose to the neoplastic tissue, first of all we recommend inverse-square law using the table of effective SSDs with cone sizes and energies respectively or simply to create a table of extended SSD air gap correction factor. The second we need to have an insight into some change of dose distribution including PPD, penumbra caused by extended SSD for electron beam therapy.

  10. New developments of 11C post-accelerated beams for hadron therapy and imaging

    CERN Document Server

    Augusto, R S; Wenander, F; Penescu, L; Orecchia, R; Parodi, K; Ferrari, A; Stora, T

    2016-01-01

    Hadron therapy was first proposed in 1946 and is by now widespread throughout the world, as witnessed with the design and construction of the CNAO, HIT, PROSCAN and MedAustron treatment centres, among others. The clinical interest in hadron therapy lies in the fact that it delivers precision treatment of tumours, exploiting the characteristic shape (the Bragg peak) of the energy deposition in the tissues for charged hadrons. In particular, carbon ion therapy is found to be biologically more effective, with respect to protons, on certain types of tumours. Following an approach tested at NIRS in Japan [1], carbon ion therapy treatments based on 12C could be combined or fully replaced with 11C PET radioactive ions post-accelerated to the same energy. This approach allows providing a beam for treatment and, at the same time, to collect information on the 3D distributions of the implanted ions by PET imaging. The production of 11C ion beams can be performed using two methods. A first one is based on the production...

  11. Pet imaging of dose distribution in proton-beam cancer therapy

    Directory of Open Access Journals (Sweden)

    Beebe-Wang Joanne

    2005-01-01

    Full Text Available Proton therapy is a treatment modality of increasing utility in clinical radiation oncology mostly because its dose distribution conforms more tightly to the target volume than X-ray radiation therapy. One important feature of proton therapy is that it produces a small amount of positron-emitting isotopes along the beam-path through the non-elastic nuclear interaction of protons with target nuclei such as 12C, 14N, and 16O. These radio isotopes, mainly 11C, 13N, and 15O, al low imaging the therapy dose distribution using positron emission tomography. The resulting positron emission tomography images provide a powerful tool for quality assurance of the treatment, especially when treating inhomogeneous organs such as the lungs or the head-and-neck, where the calculation of the dose distribution for treatment planning is more difficult. This pa per uses Monte Carlo simulations to predict the yield of positron emitters produced by a 250 MeV proton beam, and to simulate the productions of the image in a clinical PET scanner.

  12. Development of high intensity ion sources for a Tandem-Electrostatic-Quadrupole facility for Accelerator-Based Boron Neutron Capture Therapy

    International Nuclear Information System (INIS)

    Bergueiro, J.; Igarzabal, M.; Suarez Sandin, J.C.; Somacal, H.R.; Thatar Vento, V.; Huck, H.; Valda, A.A.; Repetto, M.

    2011-01-01

    Several ion sources have been developed and an ion source test stand has been mounted for the first stage of a Tandem-Electrostatic-Quadrupole facility For Accelerator-Based Boron Neutron Capture Therapy. A first source, designed, fabricated and tested is a dual chamber, filament driven and magnetically compressed volume plasma proton ion source. A 4 mA beam has been accelerated and transported into the suppressed Faraday cup. Extensive simulations of the sources have been performed using both 2D and 3D self-consistent codes.

  13. Development of high intensity ion sources for a Tandem-Electrostatic-Quadrupole facility for Accelerator-Based Boron Neutron Capture Therapy.

    Science.gov (United States)

    Bergueiro, J; Igarzabal, M; Sandin, J C Suarez; Somacal, H R; Vento, V Thatar; Huck, H; Valda, A A; Repetto, M; Kreiner, A J

    2011-12-01

    Several ion sources have been developed and an ion source test stand has been mounted for the first stage of a Tandem-Electrostatic-Quadrupole facility For Accelerator-Based Boron Neutron Capture Therapy. A first source, designed, fabricated and tested is a dual chamber, filament driven and magnetically compressed volume plasma proton ion source. A 4 mA beam has been accelerated and transported into the suppressed Faraday cup. Extensive simulations of the sources have been performed using both 2D and 3D self-consistent codes. Copyright © 2011 Elsevier Ltd. All rights reserved.

  14. Sustaining neutral beam power supply system for the Mirror Fusion Test Facility

    International Nuclear Information System (INIS)

    Eckard, R.D.; Van Ness, H.W.

    1979-01-01

    A fixed-price procurement contract for $24.9 million was awarded to Aydin Energy Division, Palo Alto, CA, for the design, manufacture, installation, and acceptance testing of the sustaining neutral beam power supply system (SNBPSS). This system is scheduled for completion in early 1981 and will provide the conditioned power for the 24 neutral beam source modules. Each of the 24 power supply sets will provide the accel potential of 80 kV at 88 A, the arc power, the filament power, and the suppressor power for its associated neutral beam source module

  15. National Ignition Facility, subsystem design requirements beam control and laser diagnostics SSDR 1.7

    International Nuclear Information System (INIS)

    Bliss, E.

    1996-01-01

    This Subsystem Design Requirement document is a development specification that establishes the performance, design, development, and test requirements for the Alignment subsystem (WBS 1.7.1), Beam Diagnostics (WBS 1.7.2), and the Wavefront Control subsystem (WBS 1.7. 3) of the NIF Laser System (WBS 1.3). These three subsystems are collectively referred to as the Beam Control ampersand Laser Diagnostics Subsystem. The NIF is a multi-pass, 192-beam, high-power, neodymium-glass laser that meets requirements set forth in the NIF SDR 002 (Laser System). 3 figs., 3 tabs

  16. Beam's-Eye-View Dosimetrics-Guided Inverse Planning for Aperture-Modulated Arc Therapy

    International Nuclear Information System (INIS)

    Ma Yunzhi; Popple, Richard; Suh, Tae-Suk; Xing Lei

    2009-01-01

    Purpose: To use angular beam's-eye-view dosimetrics (BEVD) information to improve the computational efficiency and plan quality of inverse planning of aperture-modulated arc therapy (AMAT). Methods and Materials: In BEVD-guided inverse planning, the angular space spanned by a rotational arc is represented by a large number of fixed-gantry beams with angular spacing of ∼2.5 degrees. Each beam is assigned with an initial aperture shape determined by the beam's-eye-view (BEV) projection of the planning target volume (PTV) and an initial weight. Instead of setting the beam weights arbitrarily, which slows down the subsequent optimization process and may result in a suboptimal solution, a priori knowledge about the quality of the beam directions derived from a BEVD is adopted to initi