WorldWideScience

Sample records for beam loss patterns

  1. Identification of LHC beam loss mechanism: a deterministic treatment of loss patterns

    International Nuclear Information System (INIS)

    Marsili, A.

    2012-01-01

    The goal of this work was to identify patterns in the beam loss profiles, both in their spatial distribution and time evolution. CERN's Large Hadron Collider (LHC) is the largest device ever built, with a total circumference of 26.7 km; and it is the most powerful accelerator ever, both in beam energy and beam intensity. The main magnets are superconducting, and contain the particles into two counter circulating beams which collide in four interaction points. CERN and the LHC will be described in chapter 1. The superconducting magnets of the LHC have to be protected against particle losses. Depending on the number of lost particles, the coils of the magnets could become normal conducting and/or will be damaged. To avoid these events a beam loss monitoring (BLM) system was installed to measure the particle loss rates. If the predefined safe thresholds of loss rates are exceeded, the beams are directed out of the accelerator ring towards the beam dump. The detectors of the BLM system are mainly ionization chambers located outside of the cryostats. In total, about 3600 ionisation chambers are installed. Further challenges include the high dynamical range of losses (chamber currents ranging between 2 pA and 1 mA). The BLM system will be further described in chapter 2. The subject of this thesis is to study the loss patterns and nd the origin of the losses in a deterministic way, by comparing measured losses to well understood loss scenarios. This is done through a case study: different techniques were used on a restrained set of loss scenarios, as a proof of concept of the possibility to extract information from a loss profile. Finding the origin of the losses should allow acting in response. A justification of the doctoral work will be given at the end of chapter 2. This thesis will then focus on the theoretical understanding and the implementation of the decomposition of a measured loss profile as a linear combination of the reference scenarios; and the evaluation of

  2. Identification of LHC beam loss mechanism : a deterministic treatment of loss patterns

    CERN Document Server

    Marsili, Aurélien

    CERN's Large Hadron Collider (LHC) is the largest machine ever built, with a total circumference of 26.7 km; and it is the most powerful accelerator ever, both in beam energy and beam intensity. The main magnets are superconducting, keeping the particles into two counter circulating beams, which collide in four interaction points. CERN and the LHC will be described in chap. 1. The superconducting magnets of the LHC have to be protected against particle losses. Depending on the number of lost particles, the coils of the magnets will become normal conducting and/or will be damaged. To avoid these events a beam loss monitoring (BLM) system was installed to measure the particle loss rates. If the predefined safe thresholds of loss rates are exceeded, the beams are directed out of the accelerator ring towards the beam dump. The detectors of the BLM system are mainly ionization chambers located outside of the cryostats. In total, about 3500 ionisation chambers are installed. Further challenges include the high dyna...

  3. Optimization of electron beam patterned hydrogen silsesquioxane mask edge roughness for low-loss silicon waveguides

    Science.gov (United States)

    Wood, Michael G.; Chen, Li; Burr, Justin R.; Reano, Ronald M.

    2014-01-01

    We carried out a multiparameter fabrication study designed to reduce the line edge roughness (LER) of electron beam (e-beam) patterned hydrogen silsesquioxane resist for the purpose of producing low-loss silicon strip waveguides. Reduced mask roughness was achieved for 50°C pre-exposure baking, 5000 μC/cm2 dose with a beam spot size more than twice as large as the electron beam step size, development in 25% tetramethylammonium hydroxide and postdevelopment baking with rapid thermal annealing in an O2 ambient at 1000°C. The LER caused by pattern fracturing and stage stitches was reduced with multipass writing and per-pass linear and rotational offsets. Si strip waveguides patterned with the optimized mask have root-mean-square sidewall roughness of 2.1 nm with a correlation length of 94 nm, as measured by three-dimensional atomic force microscopy. Measured optical propagation losses of these waveguides across the telecommunications C-band were 2.5 and 2.8 dB/cm for the transverse magnetic and transverse electric modes, respectively. These reduced loss waveguides enable the fabrication of advanced planar lightwave circuit topologies.

  4. Beam Loss in Linacs

    CERN Document Server

    Plum, M.A.

    2016-01-01

    Beam loss is a critical issue in high-intensity accelerators, and much effort is expended during both the design and operation phases to minimize the loss and to keep it to manageable levels. As new accelerators become ever more powerful, beam loss becomes even more critical. Linacs for H- ion beams, such as the one at the Oak Ridge Spallation Neutron Source, have many more loss mechanisms compared to H+ (proton) linacs, such as the one being designed for the European Spallation Neutron Source. Interesting H- beam loss mechanisms include residual gas stripping, H+ capture and acceleration, field stripping, black-body radiation and the recently discovered intra-beam stripping mechanism. Beam halo formation, and ion source or RF turn on/off transients, are examples of beam loss mechanisms that are common for both H+ and H- accelerators. Machine protection systems play an important role in limiting the beam loss.

  5. Fullerene-assisted electron-beam lithography for pattern improvement and loss reduction in InP membrane waveguide devices.

    Science.gov (United States)

    Jiao, Yuqing; Pello, Josselin; Mejia, Alonso Millan; Shen, Longfei; Smalbrugge, Barry; Geluk, Erik Jan; Smit, Meint; van der Tol, Jos

    2014-03-15

    In this Letter, we present a method to prepare a mixed electron-beam resist composed of a positive resist (ZEP520A) and C60 fullerene. The addition of C60 to the ZEP resist changes the material properties under electron beam exposure significantly. An improvement in the thermal resistance of the mixed material has been demonstrated by fabricating multimode interference couplers and coupling regions of microring resonators. The fabrication of distributed Bragg reflector structures has shown improvement in terms of pattern definition accuracy with respect to the same structures fabricated with normal ZEP resist. Straight InP membrane waveguides with different lengths have been fabricated using this mixed resist. A decrease of the propagation loss from 6.6 to 3.3  dB/cm has been demonstrated.

  6. Overview of LHC Beam Loss Measurements

    CERN Document Server

    Dehning, B; Effinger, E; Emery, J; Fadakis, E; Holzer, E B; Jackson, S; Kruk, G; Kurfuerst, C; Marsili, A; Misiowiec, M; Nebot Del Busto, E; Nordt, A; Priebe, A; Roderick, C; Sapinski, M; Zamantzas, C; Grishin, V; Griesmayer, E

    2011-01-01

    The LHC beam loss monitoring system provides measurements with an update rate of 1 Hz and high time resolution data by event triggering. These informations are used for the initiation of beam aborts, fixed displays and the off line analysis. The analysis of fast and localized loss events resulted in the determination of its rate, duration, peak amplitudes, its scaling with intensity, number of bunches and beam energy. The calibration of the secondary shower beam loss signal in respect to the needed beam energy deposition to quench the magnet coil is addressed at 450GeV and 3.5T eV . The adjustment of collimators is checked my measuring the loss pattern and its variation in the collimation regions of the LHC. Loss pattern changes during a fill allow the observation of non typical fill parameters.

  7. Beam Dynamics and Beam Losses - Circular Machines

    CERN Document Server

    Kain, V

    2016-01-01

    A basic introduction to transverse and longitudinal beam dynamics as well as the most relevant beam loss mechanisms in circular machines will be presented in this lecture. This lecture is intended for physicists and engineers with little or no knowledge of this subject.

  8. Female Pattern Hair Loss

    Science.gov (United States)

    ... Category: Share: Yes No, Keep Private Female Pattern Hair Loss Share | The most common type of hair loss seen in women is androgenetic alopecia, also ... men, it does not have to be complete hair loss. This is seen as hair thinning predominantly ...

  9. Female pattern hair loss

    Directory of Open Access Journals (Sweden)

    İdil Ünal

    2014-06-01

    Full Text Available Female androgenetic alopecia is the commonest cause of hair loss in women. It is characterized by a diffuse reduction in hair density over the crown and frontal scalp with retention of the frontal hairline and a characteristic pattern distribution in genetically predisposed women. Because of the uncertain relationship with the androgens Female Pattern Hair Loss (FPHL is the most preferred definition of the condition. This review has been focused on the clinical features, diagnosis and treatment alternatives of FPHL.

  10. Detection of Equipment Faults Before Beam Loss

    CERN Document Server

    Galambos, J.

    2016-01-01

    High-power hadron accelerators have strict limits on fractional beam loss. In principle, once a high-quality beam is set up in an acceptable state, beam loss should remain steady. However, in practice, there are many trips in operational machines, owing to excessive beam loss. This paper deals with monitoring equipment health to identify precursor signals that indicate an issue with equipment that will lead to unacceptable beam loss. To this end, a variety of equipment and beam signal measurements are described. In particular, several operational examples from the Spallation Neutron Source (SNS) of deteriorating equipment functionality leading to beam loss are reported.

  11. Application of diamond based beam loss monitors

    Energy Technology Data Exchange (ETDEWEB)

    Hempel, Maria [Brandenburgische Technische Univ. Cottbus (Germany); DESY, Zeuthen (Germany); CERN, Geneva (Switzerland); Baer, Tobias [CERN, Geneva (Switzerland); Hamburg Univ. (Germany); Castro Carballo, Elena Maria [DESY, Zeuthen (Germany); Lohmann, Wolfgang [Brandenburgische Technische Univ. Cottbus (Germany); DESY, Zeuthen (Germany); Schmidt, Ruediger [CERN, Geneva (Switzerland)

    2013-07-01

    The LHC has an operational stored energy of 130MJ per beam. Only a small percentage of beam losses in the LHC equipment can damage material or lead to magnet quenches. Therefore, it is important to monitor different types of beam losses, e.g. scattering on residual gas particles, UFOs, collisions and injection losses. A detailed understanding of beam loss mechanisms is necessary to reduce them and ensure save operation. Two different beam loss monitors are installed in the LHC tunnel: ionization chambers and diamond sensors. Ionization chambers trigger a beam dump if beam losses exceed a certain threshold. They have a time resolution of 40um (half LHC turn) which is not sufficient to resolve bunch-by-bunch beam losses. Diamond sensors have a nanosecond time resolution and can therefore detect bunch-by-bunch beam losses. This time resolution allows an analysis of various types of beam losses and an understanding of the mechanisms. For the first time beam loss intensities were measured bunch-by-bunch caused by different origins of losses. Beam loss measurements using diamond sensors will be presented. The results are compared to simulations and good qualitative agreement was found. The potential of diamond sensors for LHC and experiment applications are discussed.

  12. Female pattern hair loss

    Directory of Open Access Journals (Sweden)

    Archana Singal

    2013-01-01

    Full Text Available Female pattern hair loss (FPHL is a common cause of hair loss in women characterized by diffuse reduction in hair density over the crown and frontal scalp with retention of the frontal hairline. Its prevalence increases with advancing age and is associated with significant psychological morbidity. The pathophysiology of FPHL is still not completely understood and seems to be multifactorial. Although androgens have been implicated, the involvement of androgen-independent mechanisms is evident from frequent lack of clinical or biochemical markers of hyperandrogenism in affected women. The role of genetic polymorphisms involving the androgen and estrogen receptors is being increasingly recognized in its causation and predicting treatment response to anti-androgens. There are different clinical patterns and classifications of FPHL, knowledge of which facilitates patient management and research. Chronic telogen effluvium remains as the most important differential diagnosis. Thorough history, clinical examination, and evaluation are essential to confirm diagnosis. Patients with clinical signs of androgen excess require assessment of biochemical parameters and imaging studies. It is prudent to screen the patients for metabolic syndrome and cardiovascular risk factors. The treatment comprises medical and/or surgical modalities. Medical treatment should be initiated early as it effectively arrests hair loss progression rather than stimulating regrowth. Minoxidil continues to be the first line therapy whereas anti-androgens form the second line of treatment. The progressive nature of FPHL mandates long-term treatment for sustained effect. Medical therapy may be supplemented with cosmetic concealment in those desirous of greater hair density. Surgery may be worthwhile in some carefully selected patients.

  13. Beam Loss Monitors at LHC

    CERN Document Server

    Dehning, B.

    2016-01-01

    One of the main functions of the LHC beam loss measurement system is the protection of equipment against damage caused by impacting particles creating secondary showers and their energy dissipation in the matter. Reliability requirements are scaled according to the acceptable consequences and the frequency of particle impact events on equipment. Increasing reliability often leads to more complex systems. The downside of complexity is a reduction of availability; therefore, an optimum has to be found for these conflicting requirements. A detailed review of selected concepts and solutions for the LHC system will be given to show approaches used in various parts of the system from the sensors, signal processing, and software implementations to the requirements for operation and documentation.

  14. Beam Cooling with ionisation losses

    CERN Document Server

    Rubbia, Carlo; Kadi, Y; Vlachoudis, V

    2006-01-01

    A novel type of particle "cooling", called Ionization Cooling, is applicable to slow (v of the order of 0.1c) ions stored in a small ring. The many traversals through a thin foil enhance the nuclear reaction probability, in a steady configuration in which ionisation losses are recovered at each turn by a RF-cavity. For a uniform target "foil" the longitudinal momentum spread diverges exponentially since faster (slower) particles ionise less (more) than the average. In order to "cool" also longitudinally, a chromaticity has to be introduced with a wedge shaped "foil". Multiple scattering and straggling are then "cooled" in all three dimensions, with a method similar to the one of synchrotron cooling, but valid for low energy ions. Particles then stably circulate in the beam indefinitely, until they undergo for instance nuclear processes in the thin target foil. This new method is under consideration for the nuclear production of a few MeV/A ion beams. Simple reactions, for instance Li 7 + D Li 8 + p, are more ...

  15. Cryogenic Beam Loss Monitoring for the LHC

    CERN Document Server

    Kurfuerst, C; Sapinski, M

    A Beam Loss Monitoring (BLM) system was installed on the outside surface of the LHC magnet cryostats to protect the accelerator equipment from beam losses. The protection is achieved by extracting the beam from the ring in case thresholds imposed on measured radiation levels are exceeded. Close to the interaction regions of the LHC, the present BLM system is sensitive to particle showers generated in the interaction region of the two beams. In the future, with beams of higher energy and brightness resulting in higher luminosity, distinguishing between these interaction products and possible quench-provoking beam losses from the primary proton beams will be challenging. The particle showers measured by the present BLM configuration are partly shielded by the cryostat and the iron yoke of the magnets. The system can hence be optimised by locating beam loss monitors as close as possible to the protected element, i. e. the superconducting coils, inside the cold mass of the magnets in superfluid helium at 1.9 K. T...

  16. Beam Loss Monitoring for LHC Machine Protection

    Science.gov (United States)

    Holzer, Eva Barbara; Dehning, Bernd; Effnger, Ewald; Emery, Jonathan; Grishin, Viatcheslav; Hajdu, Csaba; Jackson, Stephen; Kurfuerst, Christoph; Marsili, Aurelien; Misiowiec, Marek; Nagel, Markus; Busto, Eduardo Nebot Del; Nordt, Annika; Roderick, Chris; Sapinski, Mariusz; Zamantzas, Christos

    The energy stored in the nominal LHC beams is two times 362 MJ, 100 times the energy of the Tevatron. As little as 1 mJ/cm3 deposited energy quenches a magnet at 7 TeV and 1 J/cm3 causes magnet damage. The beam dumps are the only places to safely dispose of this beam. One of the key systems for machine protection is the beam loss monitoring (BLM) system. About 3600 ionization chambers are installed at likely or critical loss locations around the LHC ring. The losses are integrated in 12 time intervals ranging from 40 μs to 84 s and compared to threshold values defined in 32 energy ranges. A beam abort is requested when potentially dangerous losses are detected or when any of the numerous internal system validation tests fails. In addition, loss data are used for machine set-up and operational verifications. The collimation system for example uses the loss data for set-up and regular performance verification. Commissioning and operational experience of the BLM are presented: The machine protection functionality of the BLM system has been fully reliable; the LHC availability has not been compromised by false beam aborts.

  17. Measuring beam losses in the THI project

    International Nuclear Information System (INIS)

    David, L.; Duneau, P.; Lecorche, E.; Lermine, P.; Lemaitre, E.; Ulrich, M.

    1997-01-01

    The goal of the THI project (High Intensity Transport) is to upgrade the GANIL facilities by increasing the beam by a factor of 15, at least for light ions. This higher intensity is required by the radioactive beam facility SPIRAL starting in September 1997, to generate the new nuclear species in the solid target-source (ISOL method). For the control system, the most important issues are now to tune the accelerators while minimizing the beam losses at each stage of acceleration and when not possible, to have a fast beam loss detection signal. This system is composed of probes which deliver a signal to stop the beam when there's too much intensity lost and when not, a logarithmic value of the beam intensity. These probes are linked to a front end VME crate on the network, and in the control room, on the workstations, a graphical user interface program displays the beam variations using logarithmic scales. This program is also used to center the beam while injecting in or ejecting from the main cyclotrons by tuning the steerers, the magnetic elements inside, and the electrostatic deflector to be able to separate and extract the last beam turn. (author)

  18. PDX neutral-beam reionization losses

    International Nuclear Information System (INIS)

    Kugel, H.W.; Dylla, H.F.; Eubank, H.P.; Kozub, T.A.; Moore, R.; Schilling, G.; Stewart, L.D.; von Halle, A.; Williams, M.D.

    1982-02-01

    Reionization losses for 1.5 MW H 0 and 2 MW D 0 neutral beams injected into the PDX tokamak were studied using pressure gauges, photo-transistors, thermocouples, surface shielding, and surface sample analysis. Considerable outgassing of conventionally prepared 304SS ducts occurred during initial injections and gradually decreased with the cumulative absorption of beam power. Reionization power losses are presently about 5% in the ducts and about 12% total for a beamline including the duct. Present duct pressures are attributed primarily to gas from the ion source and neutralizer with much smaller contributions from residual wall desorption. Physical mechanisms for the observed duct outgassing are discussed

  19. RHIC beam loss monitor system design

    International Nuclear Information System (INIS)

    Witkover, R.; Zitvogel, E.; Michnoff, R.

    1997-01-01

    The Beam Loss Monitor (BLM) System is designed to prevent the quenching of RHIC magnets due to beam loss, provide quantitative loss data, and the loss history in the event of a beam abort. The system uses 400 ion chambers of a modified Tevatron design. To satisfy fast (single turn) and slow (100 msec) loss beam criteria and provide sensitivity for studies measurements, a range of over 8 decades is needed. An RC pre-integrator reduces the dynamic range for a low current amplifier. This is digitized for data logging. The output is also applied to an analog multiplier which compensates the energy dependence, extending the range of the abort comparators. High and low pass filters separate the signal to dual comparators with independent programmable trip levels. Up to 64 channels, on 8 VME boards, are controlled by a micro-controller based VME module, decoupling it from the front-end computer (FEC) for real-time operation. Results with the detectors in the RHIC Sextant Test and the electronics in the AGS-to-RHIC (AtR) transfer line will be presented

  20. Diffraction measurements using the LHC Beam Loss Monitoring System

    Science.gov (United States)

    Kalliokoski, Matti

    2017-03-01

    The Beam Loss Monitoring (BLM) system of the Large Hadron Collider protects the machine from beam induced damage by measuring the absorbed dose rates of beam losses, and by triggering beam dump if the rates increase above the allowed threshold limits. Although the detection time scales are optimized for multi-turn losses, information on fast losses can be recovered from the loss data. In this paper, methods in using the BLM system in diffraction studies are discussed.

  1. AIP Diffraction measurements using the LHC Beam Loss Monitoring System

    CERN Document Server

    Kalliokoski, Matti

    2017-01-01

    The Beam Loss Monitoring (BLM) system of the Large Hadron Collider protects the machine from beam induced damage by measuring the absorbed dose rates of beam losses, and by triggering beam dump if the rates increase above the allowed threshold limits. Although the detection time scales are optimized for multi-turn losses, information on fast losses can be recovered from the loss data. In this paper, methods in using the BLM system in di ff raction studies are discussed.

  2. The AGS Booster beam loss monitor system

    International Nuclear Information System (INIS)

    Beadle, E.R.; Bennett, G.W.; Witkover, R.L.

    1991-01-01

    A beam loss monitor system has been developed for the Brookhaven National Laboratory Booster accelerator, and is designed for use with intensities of up to 1.5 x 10 13 protons and carbon to gold ions at 50-3 x 10 9 ions per pulse. This system is a significant advance over the present AGS system by improving the sensitivity, dynamic range, and data acquisition. In addition to the large dynamic range achievable, it is adaptively shifted when high losses are detected. The system uses up to 80 argon filled ion chambers as detectors, as well as newly designed electronics for processing and digitizing detector outputs. The hardware simultaneously integrates each detector output, interfaces to the beam interrupt systems, and digitizes all 80 channels to 21 bits at 170 KHz. This paper discuses the design, construction, and operation of the system. 4 refs., 2 figs

  3. Torsion sensing based on patterned piezoelectric beams

    Science.gov (United States)

    Cha, Youngsu; You, Hangil

    2018-03-01

    In this study, we investigated the sensing characteristics of piezoelectric beams under torsional loads. We used partially patterned piezoelectric beams to sense torsion. In particular, the piezoelectric patches are located symmetrically with respect to the line of the shear center of the beam. The patterned piezoelectric beam is modeled as a slender beam, and its electrical responses are obtained by piezoelectric electromechanical equations. To validate the modeling framework, experiments are performed using a setup that forces pure torsional deformation. Three different geometric configurations of the patterned piezoelectric layer are used for the experiments. The frequency and amplitude of the forced torsional load are systematically varied in order to study the behavior of the piezoelectric sensor. Experimental results demonstrate that two voltage outputs of the piezoelectric beam are approximately out of phase with identical amplitude. Moreover, the length of the piezoelectric layers has a significant influence on the sensing properties. Our theoretical predictions using the model support the experimental findings.

  4. Analysis of beam loss induced abort kicker instability

    Energy Technology Data Exchange (ETDEWEB)

    Zhang W.; Sandberg, J.; Ahrens, L.; Fischer, W.; Hahn, H.; Mi, J.; Pai, C.; Tan, Y.

    2012-05-20

    Through more than a decade of operation, we have noticed the phenomena of beam loss induced kicker instability in the RHIC beam abort systems. In this study, we analyze the short term beam loss before abort kicker pre-fire events and operation conditions before capacitor failures. Beam loss has caused capacitor failures and elevated radiation level concentrated at failed end of capacitor has been observed. We are interested in beam loss induced radiation and heat dissipation in large oil filled capacitors and beam triggered thyratron conduction. We hope the analysis result would lead to better protection of the abort systems and improved stability of the RHIC operation.

  5. Electron Beam Lithography for nano-patterning

    DEFF Research Database (Denmark)

    Greibe, Tine; Anhøj, Thomas Aarøe; Khomtchenko, Elena

    2014-01-01

    Electron beam lithography is a versatile tool for fabrication of nano-sized patterns. The patterns are generated by scanning a focused beam of high-energy electrons onto a substrate coated with a thin layer of electron-sensitive polymer (resist), i.e. by directly writing custom-made patterns...... in a polymer. Electron beam lithography is a suitable method for nano-sized production, research, or development of semiconductor components on a low-volume level. Here, we present electron beam lithography available at DTU Danchip. We expertize a JEOL 9500FZ with electrons accelerated to an energy of 100ke......V and focused to a beam spot size down to ~5nm. The electron beam can scan across the substrate with a speed of 100MHz and can write areas of 1mm x 1mm without stitching. In order to ensure high-precision patterning, the beam position on the substrate is controlled by a two-stage deflector system and substrates...

  6. Luminosity Loss due to Beam Distortion and the Beam-Beam Instability

    CERN Document Server

    Wu, Juhao; Raubenheimer, Tor O; Seryi, Andrei; Sramek, Christopher K

    2005-01-01

    In a linear collider, sources of emittance dilution such as transverse wakefields or dispersive errors will couple the vertical phase space to the longitudinal position within the beam (the so-called ‘banana effect'). When the Intersection Point (IP) disruption parameter is large, these beam distortions will be amplified by a single bunch kink instability which will lead to luminosity loss. We study this phenomena both analytically using linear theory and via numerical simulation. In particular, we examine the dependence of the luminosity loss on the wavelength of the beam distortions and the disruption parameter. This analysis may prove useful when optimizing the vertical disruption parameter for luminosity operation with given beam distortions.

  7. Simulation and optimization of beam losses during continuous transfer extraction at the CERN Proton Synchrotron

    CERN Document Server

    Garcia, J B

    2011-01-01

    The proton beams used for the fixed target physics at the Super Proton Synchrotron (SPS) are extracted from the Proton Synchrotron ( PS) by a multiturn technique called continuous transfer (CT). During the CT extraction, large losses are observed in locations where the machine aperture should be large enough to accommodate the circulating beam. This limits the maximum intensity deliverable due to the induced stray radiation outside the PS tunnel. Scattered particles from the interaction with the electrostatic septum are identified as the possible source of these losses. This article presents a detailed study aiming to understand the origin of losses and propose possible cures. The simulations could reproduce accurately the beam loss pattern measured in real machine operation and determine the beam shaving, intrinsic to the extraction process, as the cause for the unexpected losses. Since these losses are unavoidable, the proposed solution implies a new optics scheme displacing the losses to a region with bett...

  8. Mitigation of numerical noise for beam loss simulations

    CERN Document Server

    Kesting, Frederik

    2017-01-01

    Numerical noise emerges in self-consistent simulations of charged particles, and its mitigation is investigated since the first numerical studies in plasma physics. In accelerator physics, recent studies find an artificial diffusion of the particle beam due to numerical noise in particle-in-cell tracking, which is of particular importance for high intensity machines with a long storage time, as the SIS100 at FAIR or in context of the LIU upgrade at CERN. In beam loss simulations for these projects artificial effects must be distinguished from physical beam loss. Therefore, it is important to relate artificial diffusion to artificial beam loss, and to choose simulation parameters such that physical beam loss is well resolved. As a practical tool, we therefore suggest a scaling law to find optimal simulation parameters for a given maximum percentage of acceptable artificial beam loss.

  9. Hormonal therapy in female pattern hair loss

    Directory of Open Access Journals (Sweden)

    Kevin R. Brough

    2017-03-01

    Full Text Available Female pattern hair loss is the most common cause of hair loss in women and one of the most common problems seen by dermatologists. This hair loss is a nonscarring alopecia in which loss occurs on the vertex scalp, generally sparing the frontal hairline. Hair loss can have significant psychosocial effects on patients, and treatment can be long and difficult. The influence of hormones on the pathogenesis of female pattern hair loss is not entirely known. The purpose of this paper is to review physiology and potential hormonal mechanisms for the pathogenesis of female pattern hair loss. We also discuss the current hormonal and hormone-modifying therapies that are available to providers as they partner with patients to treat this frustrating issue.

  10. Female pattern hair loss: Current treatment concepts

    Directory of Open Access Journals (Sweden)

    Quan Q Dinh

    2007-07-01

    Full Text Available Quan Q Dinh, Rodney SinclairDepartment of Dermatology, St Vincent’s Hospital, Fitzroy, Victoria, AustraliaAbstract: Fewer than 45% of women go through life with a full head of hair. Female pattern hair loss is the commonest cause of hair loss in women and prevalence increases with advancing age. Affected women may experience psychological distress and impaired social functioning. In most cases the diagnosis can be made clinically and the condition treated medically. While many women using oral antiandrogens and topical minoxidil will regrow some hair, early diagnosis and initiation of treatment is desirable as these treatments are more effective at arresting progression of hair loss than stimulating regrowth. Adjunctive nonpharmacological treatment modalities such as counseling, cosmetic camouflage and hair transplantation are important measures for some patients. The histology of female pattern hair loss is identical to that of male androgenetic alopecia. While the clinical pattern of the hair loss differs between men, the response to oral antiandrogens suggests that female pattern hair loss is an androgen dependant condition, at least in the majority of cases. Female pattern hair loss is a chronic progressive condition. All treatments need to be continued to maintain the effect. An initial therapeutic response often takes 12 or even 24 months. Given this delay, monitoring for treatment effect through clinical photography or standardized clinical severity scales is helpful.Keywords: female pattern hair loss, androgenetic alopecia

  11. Beam Loss Monitors for NSLS-II Storage Ring

    International Nuclear Information System (INIS)

    Kramer, S.L.; Cameron, P.

    2011-01-01

    The shielding for the NSLS-II storage ring will provide adequate protection for the full injected beam losses in two cells of the ring around the injection point, but the remainder of the ring is shielded for lower losses of <10% top-off injection beam current. This will require a system to insure that beam losses do not exceed levels for a period of time that could cause excessive radiation exposure outside the shield walls. This beam Loss Control and Monitoring system will have beam loss monitors that will measure where the beam charge is lost around the ring, to warn operators if losses approach the design limits. To measure the charge loss quantitatively, we propose measuring the electron component of the shower as beam electrons hit the vacuum chamber (VC) wall. This will be done using the Cerenkov light as electrons transit ultra-pure fused silica rods placed close to the inner edge of the VC. The entire length of the rod will collect light from the electrons of the spread out shower resulting from the small glancing angle of the lost beam particles to the VC wall. The design and measurements results of the prototype Cerenkov BLM will be presented.

  12. LHC Beam Loss Monitoring System Verification Applications

    CERN Document Server

    Dehning, B; Zamantzas, C; Jackson, S

    2011-01-01

    The LHC Beam Loss Mon­i­tor­ing (BLM) sys­tem is one of the most com­plex in­stru­men­ta­tion sys­tems de­ployed in the LHC. In ad­di­tion to protecting the col­lid­er, the sys­tem also needs to pro­vide a means of di­ag­nos­ing ma­chine faults and de­liv­er a feed­back of loss­es to the control room as well as to sev­er­al sys­tems for their setup and analysis. It has to trans­mit and pro­cess sig­nals from al­most 4’000 mon­i­tors, and has near­ly 3 mil­lion con­fig­urable pa­ram­e­ters. The system was de­signed with re­li­a­bil­i­ty and avail­abil­i­ty in mind. The spec­i­fied op­er­a­tion and the fail-safe­ty stan­dards must be guar­an­teed for the sys­tem to per­form its func­tion in pre­vent­ing su­per­con­duc­tive mag­net de­struc­tion caused by par­ti­cle flux. Main­tain­ing the ex­pect­ed re­li­a­bil­i­ty re­quires ex­ten­sive test­ing and ver­i­fi­ca­tion. In this paper we re­port our most re­cent ad­di­t...

  13. Losses on SPS flat bottom and beam loading with LHC beams

    CERN Document Server

    Bartosik, H; Cettour Cave, S; Cornelis, K; Damerau, H; Goddard, B; Kain, V; Lasheen, A; Rumolo, G; Shaposhnikova, E; Timko, H

    2017-01-01

    Losses at SPS flat bottom with the LHC proton beams hadbeen studied since the earliest days the LHC beams becameavailable in the SPS. Some of the loss mechanisms involvedcould be identified and over the years of operation with thenominal 25ns LHC beam, the losses could be gradually re-duced. Nevertheless, in machine studies with high intensity25ns LHC beams it is still observed that the transmissiondegrades with intensity. As summarised in this paper, a se-ries of studies have been performed in 2016 with the aim offurther characterising the loss mechanisms and eventuallyfinding mitigation measures in view of the LHC injectorupgrade project (LIU)

  14. Classifications of patterned hair loss: a review

    Directory of Open Access Journals (Sweden)

    Mrinal Gupta

    2016-01-01

    Full Text Available Patterned hair loss is the most common cause of hair loss seen in both the sexes after puberty. Numerous classification systems have been proposed by various researchers for grading purposes. These systems vary from the simpler systems based on recession of the hairline to the more advanced multifactorial systems based on the morphological and dynamic parameters that affect the scalp and the hair itself. Most of these preexisting systems have certain limitations. Currently, the Hamilton-Norwood classification system for males and the Ludwig system for females are most commonly used to describe patterns of hair loss. In this article, we review the various classification systems for patterned hair loss in both the sexes. Relevant articles were identified through searches of MEDLINE and EMBASE. Search terms included but were not limited to androgenic alopecia classification, patterned hair loss classification, male pattern baldness classification, and female pattern hair loss classification. Further publications were identified from the reference lists of the reviewed articles.

  15. Beam loss mechanisms in relativistic heavy-ion colliders

    CERN Document Server

    Bruce, Roderik; Gilardoni, S; Wallén, E

    2009-01-01

    The Large Hadron Collider (LHC), the largest particle accelerator ever built, is presently under commissioning at the European Organization for Nuclear Research (CERN). It will collide beams of protons, and later Pb82+ ions, at ultrarelativistic energies. Because of its unprecedented energy, the operation of the LHC with heavy ions will present beam physics challenges not encountered in previous colliders. Beam loss processes that are harmless in the presently largest operational heavy-ion collider, the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory, risk to cause quenches of superconducting magnets in the LHC. Interactions between colliding beams of ultrarelativistic heavy ions, or between beam ions and collimators, give rise to nuclear fragmentation. The resulting isotopes could have a charge-to-mass ratio different from the main beam and therefore follow dispersive orbits until they are lost. Depending on the machine conditions and the ion species, these losses could occur in loca...

  16. Theory of suppression of loss cone instabilities by electron beams

    International Nuclear Information System (INIS)

    Sinha, A.; Sinha, M.

    1981-01-01

    A new mechanism for the suppression of Drift Cyclotron Loss Cone instabilities by electron beams injected along the field lines is given. The mechanism explains some of the recent observations. (author)

  17. Correlation of beam loss to residual activation in the AGS

    International Nuclear Information System (INIS)

    Brown, K.A.

    1991-01-01

    Studies of beam loss and activation at the AGS have provided a better understanding of measurements of beam loss and how they may be used to predict activation. Studies have been done in which first order correlations have been made between measured beam losses on the distributed ionization chamber system in the AGS and the health physics recorded residual activation. These studies have provided important insight into the ionization chamber system, its limitations, and its usefulness in the prediction of activation based on monitored beam loss. In recent years the AGS has run high intensity protons primarily for rare kaon decay experiments. In this mode of running the AGS typically accelerates beam from an injection momentum of 0.644 GeV/c up to a slow extracted beam (SEB) momentum of 24.2 GeV/c. The beam intensities are on the order of 4.5 x 10 13 protons per AGS cycle at injection to as high as 1.9 x 10 13 protons per AGS cycle at extraction. Residual activation varies around the AGS ring from the order of 5 mR/hour to levels of the order at 5 R/hour. The highest levels occur around the AGS beam catcher and the extraction equipment

  18. Correlation of beam loss to residual activation in the AGS

    International Nuclear Information System (INIS)

    Brown, K.A.

    1991-01-01

    Studies of beam loss and activation at the AGS have provided a better understanding of measurements of beam loss and how they may be used to predict activation. Studies have been done in which first order correlations have been made between measured beam losses on the distributed ionization chamber system in the AGS and the health physics recorded residual activation. These studies have provided important insight into the ionization chamber system, its limitations, and its usefulness in the prediction of activation based on monitored beam loss. In recent years the AGS has run high intensity protons primarily for rare known decay experiments. In this mode of running the AGS typically accelerates beam from an injection momentum of 0.644 GeV/c up to a slow extracted beam (SEB) momentum of 24.2 GeV/c. The beam intensities are on the order of 4.5 x 10 13 protons per AGS cycle at injection to as high as 1.9 x 10 13 protons per AGS cycle at extraction. Residual activation varies around the AGS ring from the order of 5 mR/hour to levels of the order at 5 R/hour. The highest levels occur around the AGS beam catcher and the extraction equipment. 7 refs., 3 figs., 2 tabs

  19. Dependence of bunch energy loss in cavities on beam velocity

    Directory of Open Access Journals (Sweden)

    Sergey S. Kurennoy

    1999-03-01

    Full Text Available Beam energy loss in a cavity can be easily computed for a relativistic bunch using time-domain codes like MAFIA or ABCI. However, for nonrelativistic beams the problem is more complicated because of difficulties with its numerical formulation in the time domain. We calculate the cavity loss factors for a bunch in frequency domain as a function of its velocity and compare results with the relativistic case.

  20. A Versatile Beam Loss Monitoring System for CLIC

    CERN Document Server

    Kastriotou, Maria; Farabolini, Wilfrid; Holzer, Eva Barbara; Nebot Del Busto, Eduardo; Tecker, Frank; Welsch, Carsten

    2016-01-01

    The design of a potential CLIC beam loss monitoring (BLM) system presents multiple challenges. To successfully cover the 48 km of beamline, ionisation chambers and optical fibre BLMs are under investigation. The former fulfils all CLIC requirements but would need more than 40000 monitors to protect the whole facility. For the latter, the capability of reconstructing the original loss position with a multi-bunch beam pulse and multiple loss locations still needs to be quantified. Two main sources of background for beam loss measurements are identified for CLIC. The two-beam accelerator scheme introduces so-called crosstalk, i.e. detection of losses originating in one beam line by the monitors protecting the other. Moreover, electrons emitted from the inner surface of RF cavities and boosted by the high RF gradients may produce signals in neighbouring BLMs, limiting their ability to detect real beam losses. This contribution presents the results of dedicated experiments performed in the CLIC Test Facility to qu...

  1. Beam Loss Calibration Studies for High Energy Proton Accelerators

    CERN Document Server

    Stockner, M

    2007-01-01

    CERN's Large Hadron Collider (LHC) is a proton collider with injection energy of 450 GeV and collision energy of 7 TeV. Superconducting magnets keep the particles circulating in two counter rotating beams, which cross each other at the Interaction Points (IP). Those complex magnets have been designed to contain both beams in one yoke within a cryostat. An unprecedented amount of energy will be stored in the circulating beams and in the magnet system. The LHC outperforms other existing accelerators in its maximum beam energy by a factor of 7 and in its beam intensity by a factor of 23. Even a loss of a small fraction of the beam particles may cause the transition from the superconducting to the normal conducting state of the coil or cause physical damage to machine components. The unique combination of these extreme beam parameters and the highly advanced superconducting technology has the consequence that the LHC needs a more efficient beam cleaning and beam loss measurement system than previous accelerators....

  2. Application of diamond based beam loss monitors at LHC

    International Nuclear Information System (INIS)

    Hempel, Maria

    2013-04-01

    The Large Hadron Collider (LHC) was conceived in the 1980s and started the operation in 2008. It needed more than 20 years to plan and construct this accelerator and its experiments. Four main experiments are located around the ring, Compact Muon Solenoid (CMS), A Toroidal LHC Apparatus(ATLAS), A Large Ion Collider Experiment (ALICE) and LHC beauty (LHCb). Two beams that traveling in opposite direction in the LHC tunnel, collide in each of the experiments to study the questions: ''What is mass?'', ''What is the universe made of?'' and ''Why is there no antimatter?''. The four experiments take data of the collision products and try to answer the fundamental questions of physics. The two larger detectors, CMS and ATLAS, are looking for the Higgs boson to study the electroweak symmetry breaking. Both detectors were built with contrasting concepts to exclude potential error sources and to rea rm the results. The smaller experiment LHCb studies the matter-antimatter asymmetry with a focus of the beauty quark. Another smaller experiment is ALICE that studies the conditions right after the Big Bang by colliding heavy ions. The navigation of the beams is done by over 10000 magnets and each beam has a stored energy of 362MJ which correspond to the kinetic energy of a train like the TGV travelling of 150 km/h. Only a small percentage of that energy can damage the material in the LHC ring or the magnets. This would mean a repair time of months or years, without taking any data. To avoid such a scenario, it is important to monitor the beam condition and measure the amount of losses of the beam. Such losses can for example happen due to dust particles in the vacuum chambers or due to deviations of the beam parameters. Several systems called beam loss monitors (BLMs) can measure beam losses. This thesis concentrates on two of them, ionization chambers and diamond detectors. Over 3600 ionization chambers are installed in the LHC, especially near each quadrupole and next to

  3. Application of diamond based beam loss monitors at LHC

    Energy Technology Data Exchange (ETDEWEB)

    Hempel, Maria

    2013-04-15

    The Large Hadron Collider (LHC) was conceived in the 1980s and started the operation in 2008. It needed more than 20 years to plan and construct this accelerator and its experiments. Four main experiments are located around the ring, Compact Muon Solenoid (CMS), A Toroidal LHC Apparatus(ATLAS), A Large Ion Collider Experiment (ALICE) and LHC beauty (LHCb). Two beams that traveling in opposite direction in the LHC tunnel, collide in each of the experiments to study the questions: ''What is mass?'', ''What is the universe made of?'' and ''Why is there no antimatter?''. The four experiments take data of the collision products and try to answer the fundamental questions of physics. The two larger detectors, CMS and ATLAS, are looking for the Higgs boson to study the electroweak symmetry breaking. Both detectors were built with contrasting concepts to exclude potential error sources and to rea rm the results. The smaller experiment LHCb studies the matter-antimatter asymmetry with a focus of the beauty quark. Another smaller experiment is ALICE that studies the conditions right after the Big Bang by colliding heavy ions. The navigation of the beams is done by over 10000 magnets and each beam has a stored energy of 362MJ which correspond to the kinetic energy of a train like the TGV travelling of 150 km/h. Only a small percentage of that energy can damage the material in the LHC ring or the magnets. This would mean a repair time of months or years, without taking any data. To avoid such a scenario, it is important to monitor the beam condition and measure the amount of losses of the beam. Such losses can for example happen due to dust particles in the vacuum chambers or due to deviations of the beam parameters. Several systems called beam loss monitors (BLMs) can measure beam losses. This thesis concentrates on two of them, ionization chambers and diamond detectors. Over 3600 ionization chambers are installed in

  4. 2014 Joint International Accelerator School: Beam Loss and Accelerator Protection

    CERN Document Server

    JAS - Joint US-CERN-Japan-Russia Accelerator School

    2016-01-01

    Many particle accelerators operate with very high beam power and very high energy stored in particle beams as well as in magnet systems. In the future, the beam power in high intensity accelerators will further increase. The protection of the accelerator equipment from the consequences of uncontrolled release of the energy is essential. This was the motivation for organizing a first school on beam losses and accelerator protection (in general referred to as machine protection). During the school the methods and technologies to identify, mitigate, monitor and manage the technical risks associated with the operation of accelerators with high-power beams or subsystems with large stored energy were presented. At the completion of the school the participants should have been able to understand the physical phenomena that can damage machine subsystems or interrupt operations and to analyze an accelerator facility to produce a register of technical risks and the corresponding risk mitigation and management strategie...

  5. Loss management in the beta-beam decay ring

    CERN Document Server

    Chancé, Antoine

    2006-01-01

    The aim of the beta-beams is to produce pure electron neutrino and anti-neutrino highly energetic beams, coming from β-decay of the 18Ne10+ and 6He2+, both at γ = 100, directed towards experimental halls situated in the Fréjus tunnel [1], [2]. The high intensity ion beams are stored in a ring, until the ions decay. Consequently, all the injected particles will be lost anywhere around the ring generating a high level of irradiation. In order to keep a constant neutrino flux, the losses due to the decay of the radioactive ions are compensated with regular injections. The new ion beam is then merged with the stored beam with a specific RF program [3]. We have to consider two sources of losses: – The β-decay products: their magnetic rigidity being different from the reference one, they are bent differently and lost. – The losses during the injection merging process. The first one needs a particular ring design in order to insert appropriate beam stoppers at the right place. The second one needs a specific...

  6. SPS transverse beam scraping and LHC injection losses

    CERN Document Server

    Drosdal, L; Bartmann, W; Bracco, C; Cornelis, K; Goddard, B; Meddahi, M; Veyrunes, E

    2012-01-01

    Machine protection sets strict requirements for the quality of the injected beam, in particular in the transverse plane. Losses at aperture restrictions and protection elements have to be kept at a minimum. Particles in the beam tails are lost at the tight transfer line collimators and can trigger the LHC beam abort system. These particles have to be removed by scrapers in the vertical and horizontal plane in the SPS. Scraping has become vital for high intensity LHC operation. This paper shows the dependence of injection quality on the SPS scraping and discusses an improved scraper setting up strategy for better reproducibility with the current scraper system.

  7. Cherenkov Fibers for Beam Loss Monitoring at the CLIC Two Beam Module

    CERN Document Server

    van Hoorne, Jacobus Willem; Holzer, E B

    The Compact Linear Collider (CLIC) study is a feasibility study aiming at a nominal center of mass energy of 3TeV and is based on normal conducting travelling-wave accelerating structures, operating at very high field gradients of 100 MV/m. Such high fields require high peak power and hence a novel power source, the CLIC two beam system, has been developed, in which a high intensity, low energy drive beam (DB) supplies energy to a high energy, low intensity main beam (MB). At the Two Beam Modules (TBM), which compose the 2x21km long CLIC main linac, a protection against beam losses resulting from badly controlled beams is necessary and particularly challenging, since the beam power of both main beam (14 MW) and drive beam (70 MW) is impressive. To avoid operational downtimes and severe damages to machine components, a general Machine Protection System (MPS) scheme has been developed. The Beam Loss Monitoring (BLM) system is a key element of the CLIC machine protection system. Its main role will be to detect p...

  8. Wetland Loss Patterns and Inundation-Productivity ...

    Science.gov (United States)

    Tidal salt marsh is a key defense against, yet is especially vulnerable to, the effects of accelerated sea level rise. To determine whether salt marshes in southern New England will be stable given increasing inundation over the coming decades, we examined current loss patterns, inundation-productivity feedbacks, and sustaining processes. A multi-decadal analysis of salt marsh aerial extent using historic imagery and maps revealed that salt marsh vegetation loss is both widespread and accelerating, with vegetation loss rates over the past four decades summing to 17.3 %. Landward retreat of the marsh edge, widening and headward expansion of tidal channel networks, loss of marsh islands, and the development and enlargement of interior depressions found on the marsh platform contributed to vegetation loss. Inundation due to sea level rise is strongly suggested as a primary driver: vegetation loss rates were significantly negatively correlated with marsh elevation (r2 = 0.96; p = 0.0038), with marshes situated below mean high water (MHW) experiencing greater declines than marshes sitting well above MHW. Growth experiments with Spartina alterniflora, the Atlantic salt marsh ecosystem dominant, across a range of elevations and inundation regimes further established that greater inundation decreases belowground biomass production of S. alterniflora and, thus, negatively impacts organic matter accumulation. These results suggest that southern New England salt ma

  9. Implementation of Beam-Loss Monitor systems for the SSC

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, R.G.

    1994-07-01

    Beam-Loss Monitors (BLM) are used with each accelerator in the Superconducting Super Collider complex. The primary purpose of these detectors is to protect the accelerators from damage due to the loss of protons. Although the range of primary beam energies to be covered is very large, 20 MeV to 20 TeV, we plan to maintain commonality of detectors and electronics as much as possible. In this report the plans for developing and implementing BLM systems for each of the accelerators will be discussed. Possible solutions to problems that have been identified are presented.

  10. Simulation and Measurements of Beam Losses on LHC Collimators During Beam Abort Failures

    CERN Document Server

    Lari, L; Bruce, R; Goddard, B; Redaelli, S; Salvachua, B; Valentino, G; Faus-Golfe, A

    2013-01-01

    One of the main purposes of tracking simulations for collimation studies is to produce loss maps along the LHC ring, in order to identify the level of local beam losses during nominal and abnormal operation scenarios. The SixTrack program is the standard tracking tool used at CERN to perform these studies. Recently, it was expanded in order to evaluate the proton load on different collimators in case of fast beam failures. Simulations are compared with beam measurements at 4 TeV. Combined failures are assumed which provide worst-case scenarios of the load on tungsten tertiary collimators.

  11. Beam Loss Monitoring for Run 2 of the LHC

    CERN Document Server

    Kalliokoski, Matti; Dehning, Bernd; Domingues Sousa, Fernando; Effinger, Ewald; Emery, Jonathan; Grishin, Viatcheslav; Holzer, Eva Barbara; Jackson, Stephen; Kolad, Blazej; Nebot Del Busto, Eduardo; Picha, Ondrej; Roderick, Chris; Sapinski, Mariusz; Sobieszek, Marcin; Zamantzas, Christos

    2015-01-01

    The Beam Loss Monitoring (BLM) system of the LHC consists of over 3600 ionization chambers. The main task of the system is to prevent the superconducting magnets from quenching and protect the machine components from damage, as a result of critical beam losses. The BLM system therefore requests a beam abort when the measured dose in the chambers exceeds a threshold value. During Long Shutdown 1 (LS1) a series of modifications were made to the system. Based on the experience from Run 1 and from improved simulation models, all the threshold settings were revised, and modified where required. This was done to improve the machine safety at 7 TeV, and to reduce beam abort requests when neither a magnet quench or damage to machine components is expected. In addition to the updates of the threshold values, about 800 monitors were relocated. This improves the response to unforeseen beam losses in the millisecond time scale due to micron size dust particles present in the vacuum chamber. This contribution will discuss...

  12. Update on beam loss monitoring at CTF3 for CLIC

    CERN Document Server

    Devlin, L J; Effinger, E; Holzer, E B; del Busto, E N; Mallows, S; Branger, E

    2013-01-01

    The primary role of the beam loss monitoring (BLM) system for the compact linear collider (CLIC) study is to work within the machine protection system. Due to the size of the CLIC facility, a BLM that covers large distances along the beam line is highly desirable, in particular for the CLIC drive beam decelerators, which would alternatively require some ~40,000 localised monitors. Therefore, an optical fibre BLM system is currently under investigation which can cover large sections of beam line at a time. A multimode fibre has been installed along the Test Beam Line at the CLIC test facility (CTF3) where the detection principle is based on the production of Cherenkov photons within the fibre resulting from beam loss and their subsequent transport along the fibre where they are then detected at the fibre ends using silicon photomultipliers. Several additional monitors including ACEMs, PEP-II and diamond detectors have also been installed. In this contribution the first results from the BLMs are presented, comp...

  13. LHC Beam Instrumentation: Beam Loss and Tune Measurements (3/3)

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    The LHC is equipped with a full suite of sophisticated beam instrumentation which has been essential for rapid commissioning, the safe increase in total stored beam power and the understanding of machine optics and accelerator physics phenomena. These lectures will introduce these systems and comment on their contributions to the various stages of beam operation. They will include details on: the beam position system and its use for real-time global orbit feedback; the beam loss system and its role in machine protection; total and bunch by bunch intensity measurements; tune measurement and feedback; diagnostics for transverse beam size measurements, abort gap monitoring and longitudinal density measurements. Issues and problems encountered along the way will also be discussed together with the prospect for future upgrades.

  14. Long radiation detector system for beam loss monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Balsamo, J.; Fewell, N.M.; Klein, J.D.; Witkover, R.L.

    1977-01-01

    The Long Radiation Monitor (LRM) system installed at the 200 MeV linac at Brookhaven National Laboratory is described. This system allows observation of both the spatial and temporal character of the losses in the linac and its transport lines. An array of large diameter gas filled coaxial cables are used as extended ion chambers to detect the losses. The output signals are available as a histogram, video waveforms, and numerical data via the computer. A fast beam interrupt is also provided. The detector characteristics and details of the processing electronics are presented. Results of studies of longitudinal, steering and focusing losses are described.

  15. Long radiation detector system for beam loss monitoring

    International Nuclear Information System (INIS)

    Balsamo, J.; Fewell, N.M.; Klein, J.D.; Witkover, R.L.

    1977-01-01

    The Long Radiation Monitor (LRM) system installed at the 200 MeV linac at Brookhaven National Laboratory is described. This system allows observation of both the spatial and temporal character of the losses in the linac and its transport lines. An array of large diameter gas filled coaxial cables are used as extended ion chambers to detect the losses. The output signals are available as a histogram, video waveforms, and numerical data via the computer. A fast beam interrupt is also provided. The detector characteristics and details of the processing electronics are presented. Results of studies of longitudinal, steering and focusing losses are described

  16. Pattern of glaucomatous neuroretinal rim loss.

    Science.gov (United States)

    Jonas, J B; Fernández, M C; Stürmer, J

    1993-01-01

    In advancing glaucomatous optic nerve damage, the area of the neuroretinal rim progressively diminishes, and its form continuously changes. This cross-sectional study was undertaken to establish a set pattern behind glaucomatous rim loss. The authors evaluated morphometrically stereo color optic disc photographs of 801 glaucomatous eyes and 496 visually normal eyes. Compared with the visually normal eyes, glaucomatous neuroretinal rim loss occurred in all sectors of the optic disc with regional preferences depending on the stage of the disease. In the eyes with modest glaucomatous damage, rim loss was usually most pronounced in the inferotemporal disc region. In the eyes with moderately progressed glaucomatous changes, rim was decreased most markedly in the superotemporal sector, then in the temporal horizontal area, the nasal inferior region, and finally in the superior nasal sector. In very advanced glaucoma, rim remnants usually were present only in the nasal disc region. At that stage, they were significantly larger in the superior nasal region than in the nasal inferior area. Other than occurring in a diffuse way, glaucomatous neuroretinal rim loss took place in a sequence of sectors. Generally, it began in the inferotemporal disc region and then progressed to the superotemporal, the temporal horizontal, the inferior nasal, and finally the superior nasal sectors. This correlates with the progression of visual field defects and the morphology of the lamina cribrosa. This finding may be important for "early" glaucoma diagnosis.

  17. Beam loss control on the ISIS synchrotron simulations, measurements, upgrades

    CERN Document Server

    Warsop, C M

    2003-01-01

    The ISIS 800 MeV proton synchrotron presently provides 2.5*10/sup 13/ protons per pulse at 50 Hz, corresponding to a mean power of 160 kW. A dual harmonic RF system upgrade, now being installed, is expected to increase the intensity and power to about 3.75*10/sup 13/ ppp and 240 kW respectively. This paper describes work presently underway to understand and optimise beam loss control, which is a dominant factor determining operational performance. The main features of the collimation system are described, and Monte Carlo simulations of the loss control process are used to understand variations of efficiency with beam loss mode (growth rate, plane). Results of simulations are compared with measurements and operational data. Improvements to measurements are also outlined.

  18. Application of Diamond Based Beam Loss Monitors at LHC

    CERN Document Server

    AUTHOR|(CDS)2080642; Lohmann, W; Rüdiger, S

    2013-05-14

    The Large Hadron Collider (LHC) was conceived in the 1980s and started the operation in 2008. It needed more than 20 years to plan and construct this accelerator and its experiments. Four main experiments are located around the ring, Compact Muon Solenoid (CMS), A Toroidal LHC Apparatus (ATLAS), A Large Ion Collider Experiment (ALICE) and LHC beauty (LHCb). Two beams that traveling in opposite direction in the LHC tunnel, collide in each of the experiments. The navigation of the beams is done by over 10000 magnets and each beam has a stored energy of 362MJ which correspond to the kinetic energy of a train like the TGV travelling of 150km/h. Only a small percentage of that energy can damage the material in the LHC ring or the magnets. This would mean a repair time of months or years, without taking any data. To avoid such a scenario, it is important to monitor the beam condition and measure the amount of losses of the beam. Such losses can for example happen due to dust particles in the vacuum chambers or due...

  19. Performance and perspectives of the diamond based Beam Condition Monitor for beam loss monitoring at CMS

    CERN Document Server

    AUTHOR|(CDS)2080862

    2015-01-01

    At CMS, a beam loss monitoring system is operated to protect the silicon detectors from high particle rates, arising from intense beam loss events. As detectors, poly-crystalline CVD diamond sensors are placed around the beam pipe at several locations inside CMS. In case of extremely high detector currents, the LHC beams are automatically extracted from the LHC rings.Diamond is the detector material of choice due to its radiation hardness. Predictions of the detector lifetime were made based on FLUKA monte-carlo simulations and irradiation test results from the RD42 collaboration, which attested no significant radiation damage over several years.During the LHC operational Run1 (2010 â?? 2013), the detector efficiencies were monitored. A signal decrease of about 50 times stronger than expectations was observed in the in-situ radiation environment. Electric field deformations due to charge carriers, trapped in radiation induced lattice defects, are responsible for this signal decrease. This so-called polarizat...

  20. Ionization Chambers for the LHC Beam Loss Detection

    CERN Document Server

    Assmann, R W; Ferioli, G; Gschwendtner, E; Kain, V

    2003-01-01

    At the Large Hadron Collider (LHC) a beam loss system will be used to prevent and protect superconducting magnets against coil quenches and coil damages. Ionisation chambers will be mounted outside the cryostat to measure the secondary shower particles caused by lost beam particles. Since the stored particle beam intensity is eight orders of magnitude larger than the lowest quench level and the losses should be detected with a relative error of two, the design and the location of the detectors have to be optimised. For that purpose a two-fold simulation was carried out. The longitudinal loss locations of the tertiary halo is investigated by tracking the halo through several magnet elements. These loss distributions are combined with simulations of the particle fluence outside the cryostat, which is induced by lost protons at the vacuum pipe. The base-line ionisation chamber has been tested at the PS Booster in order to determine the detector response at the high end of the dynamic range.

  1. A Fast CVD Diamond Beam Loss Monitor for LHC

    CERN Document Server

    Griesmayer, E; Dobos, D; Effinger, E; Pernegger, H

    2011-01-01

    Chemical Vapour Deposition (CVD) diamond detectors were installed in the collimation area of the CERN LHC to study their feasibility as Fast Beam Loss Monitors in a high-radiation environment. The detectors were configured with a fast, radiation-hard pre-amplifier with a bandwidth of 2 GHz. The readout was via an oscilloscope with a bandwidth of 1 GHz and a sampling rate of 5 GSPS. Despite the 250 m cable run from the detectors to the oscilloscope, single MIPs were resolved with a 2 ns rise time, a pulse width of 10 ns and a time resolution of less than 1 ns. Two modes of operation were applied. For the analysis of unexpected beam aborts, the loss profile was recorded in a 1 ms buffer and, for nominal operation, the histogram of the time structure of the losses was recorded in synchronism with the LHC period of 89.2 μs. Measurements during the LHC start-up (February to December 2010) are presented. The Diamond Monitors gave an unprecedented insight into the time structure of the beam losses resolving the 400...

  2. RFQ Designs and Beam-Loss Distributions for IFMIF

    Energy Technology Data Exchange (ETDEWEB)

    Jameson, Robert A [ORNL

    2007-01-01

    The IFMIF 125 mA cw 40 MeV accelerators will set an intensity record. Minimization of particle loss along the accelerator is a top-level requirement and requires sophisticated design intimately relating the accelerated beam and the accelerator structure. Such design technique, based on the space-charge physics of linear accelerators (linacs), is used in this report in the development of conceptual designs for the Radio-Frequency-Quadrupole (RFQ) section of the IFMIF accelerators. Design comparisons are given for the IFMIF CDR Equipartitioned RFQ, a CDR Alternative RFQ, and new IFMIF Post-CDR Equipartitioned RFQ designs. Design strategies are illustrated for combining several desirable characteristics, prioritized as minimum beam loss at energies above ~ 1 MeV, low rf power, low peak field, short length, high percentage of accelerated particles. The CDR design has ~0.073% losses above 1 MeV, requires ~1.1 MW rf structure power, has KP factor 1.7,is 12.3 m long, and accelerates ~89.6% of the input beam. A new Post-CDR design has ~0.077% losses above 1 MeV, requires ~1.1 MW rf structure power, has KP factor 1.7 and ~8 m length, and accelerates ~97% of the input beam. A complete background for the designs is given, and comparisons are made. Beam-loss distributions are used as input for nuclear physics simulations of radioactivity effects in the IFMIF accelerator hall, to give information for shielding, radiation safety and maintenance design. Beam-loss distributions resulting from a ~1M particle input distribution representative of the IFMIF ECR ion source are presented. The simulations reported were performed with a consistent family of codes. Relevant comparison with other codes has not been possible as their source code is not available. Certain differences have been noted but are not consistent over a broad range of designs and parameter range. The exact transmission found by any of these codes should be treated as indicative, as each has various sensitivities in

  3. Beam Losses and Lifetime of the LHC Beam in the SPS

    CERN Document Server

    Bohl, T; Shaposhnikova, Elena; Tückmantel, Joachim

    2006-01-01

    Studies of the LHC beam loss in the SPS started in 2003 [1], [2] and continued in 2004. The flat bottom losses strongly depend on the batch intensity and the RF voltage. For beam with the 75 ns spacing at the same bunch intensity they are smaller than for the 25 ns spaced bunches. Large voltage on the flat bottom together with some optimum voltage at injection helps to reduce losses. Analysis of data from 2003 has shown that observations are compatible with a diffusion like process on the flat bottom. Therefore significant time during 2004 was devoted to studies of possible RF noise sources. However the main improvement in beam lifetime on the flat bottom was observed after a change in the working point in the transverse plane (MD on 1.09.2004). In this Note we present measurements of beam loss and lifetime done during several dedicated SPS MDs for different conditions in the ring. Analysis of beam coasts will be presented separately.

  4. Classification of Male-pattern Hair Loss.

    Science.gov (United States)

    Wirya, Christopher Toshihiro; Wu, Wenyu; Wu, Kejia

    2017-01-01

    Male-pattern hair loss (MPHL) is a condition that affects the majority of men during adulthood. This condition is not life threatening but needs constant treatment and monitoring, especially in recent years where male appearance is gaining significant importance in society. An ideal classification with high amount of detail, practicality, and reproducibility is required to accurately diagnose and monitor this condition regularly and to assess the outcome of treatment. Numerous classifications have been invented, but many variants with different levels of detail, practicality, and reproducibility may cause confusion among clinicians. One clinician may not accurately able to convey accurate clinical description if different classifications are used. To avoid confusion, a new classification that can balance detail, practicality, and reproducibility is required. We hope that this will translate to better treatment and monitoring for patients. This review article aims to review different existing MPHL classifications and how it compares to each other in terms of detail, practicality, and reproducibility.

  5. Examination of the CLIC drive beam pipe design for thermal distortion caused by distributed beam loss

    CERN Document Server

    Johnson, C D

    1997-01-01

    Beam transport programs are widely used to estimate the distribution of power deposited in accelerator structures by particle beams, either intentionally as for targets or beam dumps or accidentally owing to beam loss incidents. While this is usually adequate for considerations of radiation safety, it does not reveal the expected temperature rise and its effect on structural integrity. To find this, thermal diffusion must be taken into account, requiring another step in the analysis. The method that has been proposed is to use the output of a transport program, perhaps modified, as input for a finite element analysis program that can solve the thermal diffusion equation. At CERN, the design of the CLIC drive beam pipe has been treated in this fashion. The power distribution produced in the walls by a distributed beam loss was found using the electron gamma shower code EGS4. The distribution of power density was then used to form the input for the finite element analysis program ANSYS, which was able to find t...

  6. Interaction between corrosion crack width and steel loss in RC beams corroded under load

    International Nuclear Information System (INIS)

    Malumbela, Goitseone; Alexander, Mark; Moyo, Pilate

    2010-01-01

    This paper presents results and discussions on an experimental study conducted to relate the rate of widening of corrosion cracks with the pattern of corrosion cracks as well as the level of steel corrosion for RC beams (153 x 254 x 3000 mm) that were corroded whilst subjected to varying levels of sustained loads. Steel corrosion was limited to the tensile reinforcement and to a length of 700 mm at the centre of the beams. The rate of widening of corrosion cracks as well as strains on uncracked faces of RC beams was constantly monitored during the corrosion process, along the corrosion region and along other potential cracking faces of beams using a demec gauge. The distribution of the gravimetric mass loss of steel along the corrosion region was measured at the end of the corrosion process. The results obtained showed that: the rate of widening of each corrosion crack is dependent on the overall pattern of the cracks whilst the rate of corrosion is independent of the pattern of corrosion cracks. A mass loss of steel of 1% was found to induce a corrosion crack width of about 0.04 mm.

  7. Tunable twin Airy beams induced by binary phase patterns.

    Science.gov (United States)

    Fan, Yongtao; Wei, Jingsong; Ma, Jianyong; Wang, Yang; Wu, Yiqun

    2013-04-15

    In this work, we theoretically and experimentally study the physical process of Airy beams induced by binary phase patterns combined with a slope factor. Theoretical simulations show that the binary phase patterns generate a pair of symmetrically inverted twin Airy beams. The slope factor can regulate the spacing between the two Airy beam peaks, decrease the error induced by the binarization process, and adjust the position of the focus formed by the twin Airy beams. The experimental results are consistent with the theoretical ones.

  8. Measurement of Beam Loss at the Australian Synchrotron

    CERN Document Server

    Holzer, EB; Kastriotou, M; Boland, MJ; Jackson, PD; Rasool, RP; Schmidt, J; Welsch, CP

    2014-01-01

    The unprecedented requirements that new machines are setting on their diagnostic systems is leading to the development of new generation of devices with large dynamic range, sensitivity and time resolution. Beam loss detection is particularly challenging due to the large extension of new facilities that need to be covered with localized detector. Candidates to mitigate this problem consist of systems in which the sensitive part of the radiation detectors can be extended over long distance of beam lines. In this document we study the feasibility of a BLM system based on optical fiber as an active detector for an electron storage ring. The Australian Synchrotron (AS) comprises a 216m ring that stores electrons up to 3GeV. The Accelerator has recently claimed the world record ultra low transverse emittance (below pm rad) and its surroundings are rich in synchrotron radiation. Therefore, the AS provides beam conditions very similar to those expected in the CLIC/ILC damping rings. A qualitative benchmark of beam l...

  9. 2014 CERN Accelerator Schools: Beam Loss and Accelerator Protection

    CERN Multimedia

    2014-01-01

    The US-CERN-JAPAN-RUSSIA Joint International Accelerator School is organising a course on Beam Loss and Accelerator Protection to be held in Newport Beach, California, USA from 5-14 November, 2014.    This school is intended for physicists and engineers who are or may be engaged in the design, construction, and/or operation of accelerators with high power photon or particle beams and/or accelerator sub-systems with large stored energy. Application deadlines are 15 August and 4 September. Further information on this Joint School can be found at: http://cas.web.cern.ch/cas/JAS/Newport%20Beach%202014/NPBadvert.html http://indico.cern.ch/event/287647/ http://uspas.fnal.gov/programs/JAS/JAS14.shtml

  10. Prompt loss of beam ions in KSTAR plasmas

    Directory of Open Access Journals (Sweden)

    Jun Young Kim

    2016-10-01

    Full Text Available For a toroidal plasma facility to realize fusion energy, researching the transport of fast ions is important not only due to its close relation to the heating and current drive efficiencies but also to determine the heat load on the plasma-facing components. We present a theoretical analysis and orbit simulation for the origin of lost fast-ions during neutral beam injection (NBI heating in Korea Superconducting Tokamak Advanced Research (KSTAR device. We adopted a two-dimensional phase diagram of the toroidal momentum and magnetic moment and describe detectable momentums at the fast-ion loss detector (FILD position as a quadratic line. This simple method was used to model birth ions deposited by NBI and drawn as points in the momentum phase space. A Lorentz orbit code was used to calculate the fast-ion orbits and present the prompt loss characteristics of the KSTAR NBI. The scrape-off layer deposition of fast ions produces a significant prompt loss, and the model and experimental results closely agreed on the pitch-angle range of the NBI prompt loss. Our approach can provide wall load information from the fast ion loss.

  11. Gas flow and related beam losses in the ITER neutral beam injector

    International Nuclear Information System (INIS)

    Krylov, A.; Hemsworth, R.S.

    2006-01-01

    The gas flow in the ITER neutral beam injectors has been studied using a 3D Monte-Carlo code to define a number of key parameters affecting the design and operation of the injector. This paper presents the results of calculations of the gas density in the two accelerator concepts presently considered as options for the ITER injectors, and the resultant stripping losses of the negative ions during their acceleration to 1 MeV. The sensitivity of the model to various parameters has been studied, including the gas temperature in the ion source and the subsequent accommodation by collisions with the accelerator structure, and the degree of dissociation of the D 2 or H 2 in the ion source, and subsequent recombination during collisions with the accelerator structure. Additionally the sensitivity of the losses to details of the beam source design and operating parameters are examined for the both accelerator concepts. (author)

  12. Patterned electrochemical deposition of copper using an electron beam

    Directory of Open Access Journals (Sweden)

    Mark den Heijer

    2014-02-01

    Full Text Available We describe a technique for patterning clusters of metal using electrochemical deposition. By operating an electrochemical cell in the transmission electron microscope, we deposit Cu on Au under potentiostatic conditions. For acidified copper sulphate electrolytes, nucleation occurs uniformly over the electrode. However, when chloride ions are added there is a range of applied potentials over which nucleation occurs only in areas irradiated by the electron beam. By scanning the beam we control nucleation to form patterns of deposited copper. We discuss the mechanism for this effect in terms of electron beam-induced reactions with copper chloride, and consider possible applications.

  13. Antenna Beam Pattern Characteristics of HAPS User Terminal

    Science.gov (United States)

    Ku, Bon-Jun; Oh, Dae Sub; Kim, Nam; Ahn, Do-Seob

    High Altitude Platform Stations (HAPS) are recently considered as a green infrastructure to provide high speed multimedia services. The critical issue of HAPS is frequency sharing with satellite systems. Regulating antenna beam pattern using adaptive antenna schemes is one of means to facilitate the sharing with a space receiver for fixed satellite services on the uplink of a HAPS system operating in U bands. In this letter, we investigate antenna beam pattern characteristics of HAPS user terminals with various values of scan angles of main beam, null position angles, and null width.

  14. Secondary Electron Emission Beam Loss Monitor for LHC

    CERN Document Server

    Dehning, B; Holzer, E B; Kramer, Daniel

    2008-01-01

    Beam Loss Monitoring (BLM) system is a vital part of the active protection of the LHC accelerators' elements. It should provide the number of particles lost from the primary hadron beam by measuring the radiation field induced by their interaction with matter surrounding the beam pipe. The LHC BLM system will use ionization chambers as standard detectors but in the areas where very high dose rates are expected, the Secondary Emission Monitor (SEM) chambers will be employed because of their high linearity, low sensitivity and fast response. The SEM needs a high vacuum for proper operation and has to be functional for up to 20 years, therefore all the components were designed according to the UHV requirements and a getter pump was included. The SEM electrodes are made of Ti because of its Secondary Emission Yield (SEY) stability. The sensitivity of the SEM was modeled in Geant4 via the Photo-Absorption Ionization module together with custom parameterization of the very low energy secondary electron production. ...

  15. Small angle scatter imaging from wide beam diffraction patterns

    International Nuclear Information System (INIS)

    Wilkinson, Steven J; Rogers, Keith D; Hall, Chris J; Round, Adam R

    2007-01-01

    In this paper we report on the extension of the technique of mapping small angle x-ray scatter (SAXS) across a soft material specimen several millimetres square. In the conventional SAXS mapping technique a pencil beam of x-rays is raster scanned over the specimen with the scatter pattern recorded from each point in the raster. In our technique a wide, parallel beam is used, speeding up the data collection time considerably. An image processing algorithm is used to separate the scatter pattern features from individual points along the line of the beam. To test the efficacy of the technique a phantom was constructed using gelatin and rat tail tendon collagen. Collagen fibres in the phantom were arranged in quarters horizontally, diagonally and vertically leaving one quarter with just gelatin. The phantom was used to collect both raster scanned sets of SAXS patterns spaced at 0.25 mm horizontally and vertically and also a wide beam data set. The width of the beam in this case was approximately 7 mm. Using the third-order diffraction of rat tail tendon intensity data were gathered from each SAXS pattern and used to construct a map. Data from the raster scan image and that from the wide beam are compared. Finally using a phantom made from dehydrated rat tail tendon and paraffin wax a tomographic slice constructed using data from SAXS patterns is shown

  16. Focal Atrichia: A Diagnostic Clue in Female Pattern Hair Loss.

    Science.gov (United States)

    Olsen, Elise A; Whiting, David A

    2017-10-07

    Focal atrichia is a common clinical finding in female pattern hair loss whose specificity and histologic findings need further clarification. To determine the frequency of focal atrichia in various types of hair loss and its histologic characteristics in female pattern hair loss. Part 1: Review of 250 consecutive female patients seen with hair loss for the presence of focal atrichia and Part 2: paired biopsies of haired areas vs focal atrichia in 18 subjects with female pattern hair loss RESULTS: Focal atrichia was seen in 46/104 (44%) of women with female pattern hair loss, including 67% of late onset vs 15% of early onset, compared to 3/146 (2%) of those with other hair disorders Biopsy findings of focal atrichia in female pattern hair loss showed primarily a more progressive miniaturization process than that of haired areas of the scalp. Some women with female pattern hair loss may have had concomitant chronic telogen effluvium CONCLUSIONS: When present, focal atrichia is a clinical clue to the diagnosis of female pattern hair loss, particularly late onset subtype. Copyright © 2017. Published by Elsevier Inc.

  17. Vertex Accentuation in Female Pattern Hair Loss in Asians

    Directory of Open Access Journals (Sweden)

    Chavalit Supsrisunjai

    2016-05-01

    Full Text Available Background: The most common cause of hair loss seen in women is female pattern hair loss (FPHL, also known as female androgenetic alopecia. It affects the central part of the scalp, but spares the frontal hairline. Frontal accentuation was also described by Olsen. In Asian women, vertex thinning patterns are frequently developed, but there has been no report about vertex thinning pattern in female pattern hair loss. Objective: To find prevalence of vertex accentuation in female pattern hair loss (FPHL in Asian women. Methods: Scalp hair counting (n/cm2 were measured at 3 different areas; vertex, mid scalp and frontal area respectively by digital dermoscope (Dino digital AM-413T. Visual counting and photography were performed. Outcomes were evaluated by gross appearance of vertex thinning and/or hair density <120 /cm2 in any of 3 areas. Results: 143 patients were evaluated. Mean age was 45.54 years. Of the hair loss type, 36.4% were mid-scalp, 33.6% were vertex accentuation and 30.1% were frontal accentuation, respectively. Age was not significantly different among the 3 types of hair loss (P- value 0.859. Conclusion: Although the most common female pattern hair loss type is diffuse type (Ludwig type, vertex accentuation pattern is the second most common pattern in this study. This study is the first to mention “Vertex accentuation” to be another pattern for FPHL.

  18. Beam loss due to the aperture limitation resulting from intrabeam scattering

    International Nuclear Information System (INIS)

    Lee, S.Y.

    1984-01-01

    Diffusion equation is used to evaluate the beam loss in the presence of aperture limitation resulting from the intrabeam scattering. We discuss the effect of different boundary conditions. Satisfactory beam intensity can be maintained within the proposed RHIC operation time

  19. Loss of Energy Concentration in Nonlinear Evolution Beam Equations

    Science.gov (United States)

    Garrione, Maurizio; Gazzola, Filippo

    2017-12-01

    Motivated by the oscillations that were seen at the Tacoma Narrows Bridge, we introduce the notion of solutions with a prevailing mode for the nonlinear evolution beam equation u_{tt} + u_{xxxx} + f(u)= g(x, t) in bounded space-time intervals. We give a new definition of instability for these particular solutions, based on the loss of energy concentration on their prevailing mode. We distinguish between two different forms of energy transfer, one physiological (unavoidable and depending on the nonlinearity) and one due to the insurgence of instability. We then prove a theoretical result allowing to reduce the study of this kind of infinite-dimensional stability to that of a finite-dimensional approximation. With this background, we study the occurrence of instability for three different kinds of nonlinearities f and for some forcing terms g, highlighting some of their structural properties and performing some numerical simulations.

  20. Comparative study of beam losses and heat loads reduction methods in MITICA beam source

    Energy Technology Data Exchange (ETDEWEB)

    Sartori, E., E-mail: emanuele.sartori@igi.cnr.it; Agostinetti, P.; Dal Bello, S.; Marcuzzi, D.; Serianni, G.; Veltri, P. [Consorzio RFX, Euratom-ENEA association, C.so Stati Uniti 4, 35127 Padova (Italy); Sonato, P. [Consorzio RFX, Euratom-ENEA association, C.so Stati Uniti 4, 35127 Padova (Italy); Dipartimento di Ingegneria Elettrica, Padova University, Via Gradenigo 6/a, 35131 Padova (Italy)

    2014-02-15

    In negative ion electrostatic accelerators a considerable fraction of extracted ions is lost by collision processes causing efficiency loss and heat deposition over the components. Stripping is proportional to the local density of gas, which is steadily injected in the plasma source; its pumping from the extraction and acceleration stages is a key functionality for the prototype of the ITER Neutral Beam Injector, and it can be simulated with the 3D code AVOCADO. Different geometric solutions were tested aiming at the reduction of the gas density. The parameter space considered is limited by constraints given by optics, aiming, voltage holding, beam uniformity, and mechanical feasibility. The guidelines of the optimization process are presented together with the proposed solutions and the results of numerical simulations.

  1. Transient beam losses in the LHC injection kickers from micron scale dust particles

    CERN Document Server

    Goddard, B; Baer, T; Barnes, M J; Cerutti, F; Ferrari, A; Garrel, N; Gerardin, A; Guinchard, M; Lechner, A; Masi, A; Mertens, V; Morón Ballester, R; Redaelli, S; Uythoven, J; Vlachoudis, V; Zimmermann, F

    2012-01-01

    Transient beam losses on a time scale of a few ms have been observed in the LHC injection kickers, occurring mainly shortly after beam injection with a strong correlation in time to the kicker pulsing. The beam losses, which have at times affected LHC availability, are attributed to micron scale ceramic dust particles detached from the alumina beam pipe and accelerated into the beam. The beam related observations are described, together with laboratory measurements of beam pipe contamination and kicker vibration, simulations of electric field in the beam pipe and the basic dynamic model. Energy deposition simulations modelling the beam losses are presented and compared to measurement. Extrapolations to future LHC operation at higher intensities and energies are made, and prospects for mitigation are discussed.

  2. Reliability Tests of the LHC Beam Loss Monitoring FPGA Firmware

    CERN Document Server

    Hajdu, C F; Dehning, B; Jackson, S

    2010-01-01

    The LHC Beam Loss Monitoring (BLM) system is one of the most complex instrumentation systems deployed in the LHC. In addition to protecting the collider, the system also needs to provide a means of diagnosing machine faults and deliver a feedback of losses to the control room as well as to several systems for their setup and analysis. It has to transmit and process signals from almost 4’000 monitors, and has nearly 3 million configurable parameters. In a system of such complexity, firmware reliability is a critical issue. The integrity of the signal chain of the LHC BLM system and its ability to correctly detect unwanted scenarios and thus provide the required protection level must be ensured. In order to analyze the reliability and functionality, an advanced verification environment has been developed to evaluate the performance and response of the FPGA-based data analysis firmware. This paper will report on the numerous tests that have been performed and on how the results are used to quantify the reliabi...

  3. Cryogenic Beam Loss Monitors for the Superconducting Magnets of the LHC

    CERN Document Server

    Bartosik, MR; Sapinski, M; Kurfuerst, C; Griesmayer, E; Eremin, V; Verbitskaya, E

    2014-01-01

    The Beam Loss Monitor detectors close to the interaction points of the Large Hadron Collider are currently located outside the cryostat, far from the superconducting coils of the magnets. In addition to their sensitivity to lost beam particles, they also detect particles coming from the experimental collisions, which do not contribute significantly to the heat deposition in the superconducting coils. In the future, with beams of higher energy and brightness resulting in higher luminosity, distinguishing between these interaction products and dangerous quench-provoking beam losses from the primary proton beams will be challenging. The system can be optimised by locating beam loss monitors as close as possible to the superconducting coils, inside the cold mass in a superfluid helium environment, at 1.9 K. The dose then measured by such Cryogenic Beam Loss Monitors would more precisely correspond to the real dose deposited in the coil. The candidates under investigation for such detectors are based on p+-n-n+ si...

  4. NANOSTRUCTURE PATTERNING UNDER ENERGETIC PARTICLE BEAM IRRADIATION

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Lumin [Regents of the University of Michigan; Lu, Wei [Regents of the University of Michigan

    2013-01-31

    Energetic ion bombardment can lead to the development of complex and diverse nanostructures on or beneath the material surface through induced self-organization processes. These self-organized structures have received particular interest recently as promising candidates as simple, inexpensive, and large area patterns, whose optical, electronic and magnetic properties are different from those in the bulk materials [1-5]. Compared to the low mass efficiency production rate of lithographic methods, these self-organized approaches display new routes for the fabrication of nanostructures over large areas in a short processing time at the nanoscale, beyond the limits of lithography [1,4]. Although it is believed that surface nanostructure formation is based on the morphological instability of the sputtered surface, driven by a kinetic balance between roughening and smoothing actions [6,7], the fundamental mechanisms and experimental conditions for the formation of these nanostructures has still not been well established, the formation of the 3-D naopatterns beneath the irradiated surface especially needs more exploration. During the last funding period, we have focused our efforts on irradiation-induced nanostructures in a broad range of materials. These structures have been studied primarily through in situ electron microscopy during electron or ion irradiation. In particular, we have performed studies on 3-D void/bubble lattices (in metals and CaF2), embedded sponge-like porous structure with uniform nanofibers in irradiated semiconductors (Ge, GaSb, and InSb), 2-D highly ordered pattern of nanodroplets (on the surface of GaAs), hexagonally ordered nanoholes (on the surface of Ge), and 1-D highly ordered ripple and periodic arrays (of Cu nanoparticles) [3,8-11]. The amazing common feature in those nanopatterns is the uniformity of the size of nanoelements (nanoripples, nanodots, nanovoids or nanofibers) and the distance separating them. Our research focuses on the

  5. Diffuse scarring alopecia in a female pattern hair loss distribution.

    Science.gov (United States)

    Fergie, Bonnie; Khaira, Gurpreet; Howard, Vicki; de Zwaan, Sally

    2018-02-01

    We describe three cases of hair loss in a female pattern hair loss (FPHL) distribution with histologic features of lichen planopilaris (LPP). All patients had a history of diffuse, gradual hair loss in a Christmas tree pattern that clinically presented as FPHL on gross and dermoscopic examination. Notably, there were no characteristic clinical signs of LPP and no histologic features of FPHL. These cases are most consistent with cicatricial pattern hair loss (CPHL). This relatively new entity is similar to fibrosing alopecia in a pattern distribution (FAPD) in that they are both scarring alopecias confined to a FPHL distribution, but CPHL lacks the clinical signs of perifollicular erythema and perifollicular keratosis seen in FAPD. These three cases may present an early, subtle form of CPHL and will be of interest to clinicians and histopathologists alike. © 2017 The Australasian College of Dermatologists.

  6. Studies of Limits on Uncontrolled Heavy Ion Beam Losses for Allowing Hands-On Maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Reginald M. Ronningen; Igor Remec

    2010-09-11

    Dose rates from accelerator components activated by 1 W/m beam losses are obtained semiempirically for a 1 GeV proton beam and by use of Monte Carlo transport codes for the proton beam and for 777 MeV/u 3He, 500 MeV/u 48Ca, 86Kr, 136Xe, and 400 MeV/u 238U ions. The dose rate obtained by the semi-empirical method, 0.99 mSv/h (99 mrem/h) at 30 cm, 4 h after 100 d irradiation by a 1-GeV proton beam, is consistent with studies at several accelerator facilities and with adopted hands-on maintenance dose rate limits. Monte Carlo simulations verify this result for protons and extend studies to heavy ion beam losses in drift-tube linac and superconducting linac accelerating structures. The studies indicate that the 1 W/m limit imposed on uncontrolled beam losses for high-energy proton beams might be relaxed for heavy ion beams. These studies further suggest that using the ratio of neutrons produced by a heavy ion beam to neutrons produced by a proton beam along with the dose rate from the proton beam (for thin-target scenarios) should allow an estimate of the dose rates expected from heavy ion beam losses.

  7. Prepregnancy dietary patterns and risk of pregnancy loss.

    Science.gov (United States)

    Gaskins, Audrey J; Rich-Edwards, Janet W; Hauser, Russ; Williams, Paige L; Gillman, Matthew W; Penzias, Alan; Missmer, Stacey A; Chavarro, Jorge E

    2014-10-01

    Two previous case-control studies observed associations between specific food groups and risk of miscarriage; however, to our knowledge, no previous studies have investigated dietary patterns and risk of pregnancy loss. We aimed to assess prepregnancy adherence to the alternate Healthy Eating Index 2010 (aHEI-2010), alternate Mediterranean diet (aMED), and Fertility Diet (FD) and risk of pregnancy loss. Our prospective cohort study included 15,950 pregnancies reported by 11,072 women in the Nurses' Health Study II between 1992 and 2009. Diet was assessed every 4 y starting in 1991 by using a validated food-frequency questionnaire. Prepregnancy dietary pattern scores were computed as the sum of a woman's score on each pattern's predefined components. Multivariable log-binomial regression models with generalized estimating equations were used to estimate RRs and 95% CIs. Incident spontaneous abortions and stillbirths were reported in 2756 (17.3%) and 120 (0.8%) pregnancies, respectively. None of the 3 dietary patterns were associated with risk of pregnancy loss. In the multivariable model, RR of pregnancy loss for a 1-SD increase in score was 1.02 (95% CI: 0.98, 1.05) for the aMED pattern, 1.01 (95% CI: 0.98, 1.05) for the aHEI-2010 pattern, and 0.98 (95% CI: 0.95, 1.01) for the FD pattern. Results were consistent when pregnancy loss was classified as either a spontaneous abortion (loss at <20 wk) or a stillbirth (loss at ≥20 wk). Prepregnancy adherence to several dietary patterns was not associated with risk of pregnancy loss. © 2014 American Society for Nutrition.

  8. Prepregnancy dietary patterns and risk of pregnancy loss123

    Science.gov (United States)

    Gaskins, Audrey J; Rich-Edwards, Janet W; Hauser, Russ; Williams, Paige L; Gillman, Matthew W; Penzias, Alan; Missmer, Stacey A; Chavarro, Jorge E

    2014-01-01

    Background: Two previous case-control studies observed associations between specific food groups and risk of miscarriage; however, to our knowledge, no previous studies have investigated dietary patterns and risk of pregnancy loss. Objective: We aimed to assess prepregnancy adherence to the alternate Healthy Eating Index 2010 (aHEI-2010), alternate Mediterranean diet (aMED), and Fertility Diet (FD) and risk of pregnancy loss. Design: Our prospective cohort study included 15,950 pregnancies reported by 11,072 women in the Nurses’ Health Study II between 1992 and 2009. Diet was assessed every 4 y starting in 1991 by using a validated food-frequency questionnaire. Prepregnancy dietary pattern scores were computed as the sum of a woman's score on each pattern's predefined components. Multivariable log-binomial regression models with generalized estimating equations were used to estimate RRs and 95% CIs. Results: Incident spontaneous abortions and stillbirths were reported in 2756 (17.3%) and 120 (0.8%) pregnancies, respectively. None of the 3 dietary patterns were associated with risk of pregnancy loss. In the multivariable model, RR of pregnancy loss for a 1-SD increase in score was 1.02 (95% CI: 0.98, 1.05) for the aMED pattern, 1.01 (95% CI: 0.98, 1.05) for the aHEI-2010 pattern, and 0.98 (95% CI: 0.95, 1.01) for the FD pattern. Results were consistent when pregnancy loss was classified as either a spontaneous abortion (loss at <20 wk) or a stillbirth (loss at ≥20 wk). Conclusion: Prepregnancy adherence to several dietary patterns was not associated with risk of pregnancy loss. PMID:25240079

  9. Micro-patterns fabrication using focused proton beam lithography

    Czech Academy of Sciences Publication Activity Database

    Cutroneo, Mariapompea; Havránek, Vladimír; Macková, Anna; Semián, Vladimír; Torrisi, L.; Calcagno, L.

    2016-01-01

    Roč. 371, MAR (2016), s. 344-349 ISSN 0168-583X. [22nd International conference on Ion Beam Analysis (IBA). Opatija, 14.06.2015-19.06.2015] R&D Projects: GA MŠk(CZ) LM2011019; GA ČR(CZ) GBP108/12/G108 Institutional support: RVO:61389005 Keywords : ion-micro-beam * STIM analysis * pattern in PMMA Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 1.109, year: 2016

  10. Regression patterns of uveal melanomas after proton beam irradiation

    International Nuclear Information System (INIS)

    Wilkes, S.R.; Gragoudas, E.S.

    1982-01-01

    Forty-four uveal melanomas were evaluated for patterns of tumor regression after proton beam irradiation. All tumors were followed for a minimum of ten months after treatment. Seven lesions completely disappeared, 33 have decreased in size, and 4 remained unchanged. Associated signs of tumor regression were: resolution of the secondary serous retinal detachments, central apical yellow discoloration of the tumor, destruction of the tumor's vasculature, and elimination of fluorescein leakage. This study demonstrated that regression after proton beam irradiation is a relatively slow process, and the effects of radiation could be observed in some cases more than a year after treatment

  11. Beam Loss Simulation Studies for ALS Top-Off Operation

    CERN Document Server

    Nishimura, Hiroshi; Robin, David; Steier, Christoph

    2005-01-01

    The ALS is planning to operate with top-off injection at higher beam currents and smaller vertical beam size. As part of a radiation safety study for top-off, we carried out two kinds of tracking studies: (1) to confirm that the injected beam cannot go into users' photon beam lines, and (2) to control the location of beam dump when the storage ring RF is tripped. (1) is done by tracking electrons from a photon beam line to the injection sector inversely by including the magnetic field profiles, varying the field strength with geometric aperture limits to conclude that it is impossible. (2) is done by tracking an electron with radiation in the 6-dim space for different combinations of vertical scrapers for the realistic lattice with errors.

  12. TCDQ-TCT retraction and losses during asynchronous beam dump

    CERN Document Server

    Bracco, Chiara; Quaranta, Elena; CERN. Geneva. ATS Department

    2016-01-01

    The protection provided by the TCDQs in case of asynchronous beam dump depends strongly on their correct setup. They have to respect the strict hierarchy of the full collimation system and shield the tertiary collimators in the experimental regions. This MD aimed at performing asynchronous beam dump tests with different configurations, in order to assess the minimum allowed retraction between TCTs and TCDQs and, as a consequence, on the The protection provided by the TCDQs in case of asynchronous beam dump depends strongly on their correct setup. They have to respect the strict hierarchy of the full collimation system and shield the tertiary collimators in the experimental regions. This MD aimed at performing asynchronous beam dump tests with different configurations, in order to assess the minimum allowed retraction between TCTs and TCDQs and, as a consequence, on the β* reach.

  13. Angular scattering in electron capture and loss D- beam formation processes

    International Nuclear Information System (INIS)

    Coggiola, M.J.; Hodges, R.V.; Huestis, D.L.; Peterson, J.R.

    1980-01-01

    The development of high energy (> 150 keV) neutral beams for heating and fueling magnetic fusion devices depends on the ability to produce well-collimated negative ion beams. The double capture charge-exchange technique is a known, scalable method. In order to maximize the overall efficiency of the process and to achieve the desired beam characteristics, it is necessary to examine the optical qualities of the beams as well as the total efficiency of beam production. A combined modeling and experimental study of the angular scattering effects in negative ion formation and loss processes has therefore been undertaken

  14. High performance Si immersion gratings patterned with electron beam lithography

    Science.gov (United States)

    Gully-Santiago, Michael A.; Jaffe, Daniel T.; Brooks, Cynthia B.; Wilson, Daniel W.; Muller, Richard E.

    2014-07-01

    Infrared spectrographs employing silicon immersion gratings can be significantly more compact than spectro- graphs using front-surface gratings. The Si gratings can also offer continuous wavelength coverage at high spectral resolution. The grooves in Si gratings are made with semiconductor lithography techniques, to date almost entirely using contact mask photolithography. Planned near-infrared astronomical spectrographs require either finer groove pitches or higher positional accuracy than standard UV contact mask photolithography can reach. A collaboration between the University of Texas at Austin Silicon Diffractive Optics Group and the Jet Propulsion Laboratory Microdevices Laboratory has experimented with direct writing silicon immersion grating grooves with electron beam lithography. The patterning process involves depositing positive e-beam resist on 1 to 30 mm thick, 100 mm diameter monolithic crystalline silicon substrates. We then use the facility JEOL 9300FS e-beam writer at JPL to produce the linear pattern that defines the gratings. There are three key challenges to produce high-performance e-beam written silicon immersion gratings. (1) E- beam field and subfield stitching boundaries cause periodic cross-hatch structures along the grating grooves. The structures manifest themselves as spectral and spatial dimension ghosts in the diffraction limited point spread function (PSF) of the diffraction grating. In this paper, we show that the effects of e-beam field boundaries must be mitigated. We have significantly reduced ghost power with only minor increases in write time by using four or more field sizes of less than 500 μm. (2) The finite e-beam stage drift and run-out error cause large-scale structure in the wavefront error. We deal with this problem by applying a mark detection loop to check for and correct out minuscule stage drifts. We measure the level and direction of stage drift and show that mark detection reduces peak-to-valley wavefront error

  15. Consideration of neutral beam prompt loss in the design of a tokamak helicon antenna

    International Nuclear Information System (INIS)

    Pace, D.C.; Van Zeeland, M.A.; Fishler, B.; Murphy, C.

    2016-01-01

    Highlights: • Neutral beam prompt losses place appreciable power on an in-vessel tokamak antenna. • Simulations predict prompt loss power and inform protective tile design. • Experiments confirm the validity of the prompt loss simulations. - Abstract: Neutral beam prompt losses (injected neutrals that ionize such that their first poloidal transit intersects with the wall) can put appreciable power on the outer wall of tokamaks, and this power may damage the wall or other internal components. These prompt losses are simulated including a protruding helicon antenna installation in the DIII-D tokamak and it is determined that 160 kW of power will impact the antenna during the injection of a particular neutral beam. Protective graphite tiles are designed in response to this modeling and the wall shape of the installed antenna is precisely measured to improve the accuracy of these calculations. Initial experiments confirm that the antenna component temperature increases according to the amount of neutral beam energy injected into the plasma. In this case, only injection of beams that are aimed counter to the plasma current produce an appreciable power load on the outer wall, suggesting that the effect is of little concern for tokamaks featuring only co-current neutral beam injection. Incorporating neutral beam prompt loss considerations into the design of this in-vessel component serves to ensure that adequate protection or cooling is provided.

  16. Energy Deposition Simulations and Measurements in an LHC Collimator and Beam Loss Monitors

    CERN Document Server

    Böhlen, Till; Bracco, C; Dehning, B; Redaelli, S; Weiler, T; Zamantzas, C

    2010-01-01

    The LHC collimators are protected against beam-caused damages by measuring the secondary particle showers with beam loss monitors. Downstream of every collimator an ionisation chamber and a secondary emission monitor are installed to determine the energy deposition in the collimator. The relation between the energy deposition in the beam loss monitor and the collimator jaw is based on secondary shower simulations. To verify the FLUKA simulations, the prototype LHC collimator installed in the SPS was equipped with beam loss monitors. The results of the measurements of the direct impact of a 26 GeV proton beam injected in the SPS onto the collimator are compared with the predictions by FLUKA simulations. In addition, simulation results from parameter scans for mean and peak energy deposition with its dependencies are shown.

  17. Analog front end circuit design of CSNS beam loss monitor system

    International Nuclear Information System (INIS)

    Xiao Shuai; Guo Xian; Tian Jianmin; Zeng Lei; Xu Taoguang; Fu Shinian

    2013-01-01

    The China Spallation Neutron Source (CSNS) beam loss monitor system uses gas ionization chamber to detect beam losses. The output signals from ionization chamber need to be processed in the analog front end circuit, which has been designed and developed independently. The way of transimpedance amplifier was used to achieve current-voltage (I-V) conversion measurement of signal with low repetition rate, low duty cycle and low amplitude. The analog front end circuit also realized rapid response to the larger beam loss in order to protect the safe operation of the accelerator equipment. The testing results show that the analog front end circuit meets the requirements of beam loss monitor system. (authors)

  18. Patterns of bone loss around teeth restored with endodontic posts

    NARCIS (Netherlands)

    Katsamakis, S.; Timmerman, M.; van der Velden, U.; de Cleen, M.; van der Weijden, F.

    2009-01-01

    Objectives: This retrospective study described the pattern of bone loss around teeth with endodontic posts in periodontitis patients, and compared it with contra-lateral teeth without posts. Material and Methods: From full-mouth radiographic surveys of 146 periodontitis patients (35 years), 194

  19. Treatment of female pattern hair loss with oral antiandrogens

    NARCIS (Netherlands)

    Sinclair, R; Wewerinke, M; Jolley, D

    Background It has not been conclusively established that female pattern hair loss (FPHL) is either due to androgens or responsive to oral antiandrogen therapy. Objectives To evaluate the efficacy of oral antiandrogen therapy in the management of women with FPHL using standardized photographic

  20. Electron beam guiding by grooved SiO{sub 2} parallel plates without energy loss

    Energy Technology Data Exchange (ETDEWEB)

    Xue, Yingli; Yu, Deyang, E-mail: d.yu@impcas.ac.cn; Liu, Junliang; Zhang, Mingwu; Yang, Bian; Zhang, Yuezhao; Cai, Xiaohong [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China)

    2015-12-21

    Using a pair of grooved SiO{sub 2} parallel plates, stably guided electron beams were obtained without energy loss at 800–2000 eV. This shows that the transmitted electrons are guided by a self-organized repulsive electric field, paving the way for a self-adaptive manipulation of electron beams.

  1. Linear coupling, loss and gain of counterpropagating beams

    Czech Academy of Sciences Publication Activity Database

    Peřinová, V.; Lukš, A.; Křepelka, Jaromír

    2006-01-01

    Roč. 39, č. 9 (2006), s. 2267-2284 ISSN 0953-4075 R&D Projects: GA MŠk(CZ) OC P11.003 Institutional research plan: CEZ:AV0Z10100522; CEZ:AV0Z10100520 Keywords : linear coupling * counterpropagating beams Subject RIV: BH - Optics, Masers, Lasers Impact factor: 2.024, year: 2006

  2. Direct nano-patterning of graphene with helium ion beams

    International Nuclear Information System (INIS)

    Naitou, Y.; Iijima, T.; Ogawa, S.

    2015-01-01

    Helium ion microscopy (HIM) was used for direct nano-patterning of single-layer graphene (SLG) on SiO 2 /Si substrates. This technique involves irradiation of the sample with accelerated helium ions (He + ). Doses of 2.0 × 10 16  He +  cm −2 from a 30 kV beam induced a metal-insulator transition in the SLG. The resolution of HIM patterning on SLG was investigated by fabricating nanoribbons and nanostructures. Analysis of scanning capacitance microscopy measurements revealed that the spatial resolution of HIM patterning depended on the dosage of He + in a non-monotonic fashion. Increasing the dose from 2.0 × 10 16 to 5.0 × 10 16  He +  cm −2 improved the spatial resolution to several tens of nanometers. However, doses greater than 1.0 × 10 17  He +  cm −2 degraded the patterning characteristics. Direct patterning using HIM is a versatile approach to graphene fabrication and can be applied to graphene-based devices

  3. Simulations and Measurements of Secondary Electron Emission Beam Loss Monitors for LHC

    CERN Document Server

    Kramer, Daniel; Holzer, E B; Ferioli, G; Stockner, M

    2007-01-01

    Secondary Emission Monitor (SEM) is a part of the LHC Beam Loss Monitoring system, which is providing the number of particles lost from the primary hadron beam by measuring the radiation field induced by their interaction with matter surrounding the beam pipe. SEM detectors will be used in the high dose rate environments of LHC because of their low sensitivity and excellent linearity. The design of SEM consists of two bias electrodes separating the produced secondary electrons from the Ti signal electrode placed in a vacuum steel cylinder. The response of the chamber was tested with bunched and continuous proton beams and compared with a reference detector and GEANT4 simulations.

  4. Energy loss of a high charge bunched electron beam in plasma: Simulations, scaling, and accelerating wakefields

    Directory of Open Access Journals (Sweden)

    J. B. Rosenzweig

    2004-06-01

    Full Text Available The energy loss and gain of a beam in the nonlinear, “blowout” regime of the plasma wakefield accelerator, which features ultrahigh accelerating fields, linear transverse focusing forces, and nonlinear plasma motion, has been asserted, through previous observations in simulations, to scale linearly with beam charge. Additionally, from a recent analysis by Barov et al., it has been concluded that for an infinitesimally short beam, the energy loss is indeed predicted to scale linearly with beam charge for arbitrarily large beam charge. This scaling is predicted to hold despite the onset of a relativistic, nonlinear response by the plasma, when the number of beam particles occupying a cubic plasma skin depth exceeds that of plasma electrons within the same volume. This paper is intended to explore the deviations from linear energy loss using 2D particle-in-cell simulations that arise in the case of experimentally relevant finite length beams. The peak accelerating field in the plasma wave excited behind the finite-length beam is also examined, with the artifact of wave spiking adding to the apparent persistence of linear scaling of the peak field amplitude into the nonlinear regime. At large enough normalized charge, the linear scaling of both decelerating and accelerating fields collapses, with serious consequences for plasma wave excitation efficiency. Using the results of parametric particle-in-cell studies, the implications of these results for observing severe deviations from linear scaling in present and planned experiments are discussed.

  5. Epigenetic patterns in successful weight loss maintainers: a pilot study.

    Science.gov (United States)

    Huang, Yen-Tsung; Maccani, Jennifer Z J; Hawley, Nicola L; Wing, Rena R; Kelsey, Karl T; McCaffery, Jeanne M

    2015-05-01

    DNA methylation changes occur in animal models of calorie restriction, simulating human dieting, and in human subjects undergoing behavioral weight loss interventions. This suggests that obese (OB) individuals may possess unique epigenetic patterns that may vary with weight loss. Here, we examine whether methylation patterns in leukocytes differ in individuals who lost sufficient weight to go from OB to normal weight (NW; successful weight loss maintainers; SWLMs) vs currently OB or NW individuals. This study examined peripheral blood mononuclear cell (PBMC) methylation patterns in NW (n=16, current/lifetime BMI 18.5-24.9) and OB individuals (n=16, current body mass index (BMI)⩾30), and SWLM (n=16, current BMI 18.5-24.9, lifetime maximum BMI ⩾30, average weight loss 57.4 lbs) using an Illumina Infinium HumanMethylation450 BeadArray. No leukocyte population-adjusted epigenome-wide analyses were significant; however, potentially differentially methylated loci across the groups were observed in ryanodine receptor-1 (RYR1; P=1.54E-6), myelin protein zero-like 3 (MPZL3; P=4.70E-6) and alpha 3c tubulin (TUBA3C; P=4.78E-6). In 32 obesity-related candidate genes, differential methylation patterns were found in brain-derived neurotrophic factor (BDNF; gene-wide P=0.00018). In RYR1, TUBA3C and BDNF, SWLM differed from OB but not NW. In this preliminary investigation, leukocyte SWLM DNA methylation patterns more closely resembled NW than OB individuals in three gene regions. These results suggest that PBMC methylation is associated with weight status.

  6. The upgraded data acquisition system for beam loss monitoring at the Fermilab Tevatron and Main Injector

    International Nuclear Information System (INIS)

    Baumbaugh, A.; Briegel, C.; Brown, B.C.; Capista, D.; Drennan, C.; Fellenz, B.; Knickerbocker, K.; Lewis, J.D.; Marchionni, A.; Needles, C.; Olson, M.

    2011-01-01

    A VME-based data acquisition system for beam-loss monitors has been developed and is in use in the Tevatron and Main Injector accelerators at the Fermilab complex. The need for enhanced beam-loss protection when the Tevatron is operating in collider-mode was the main driving force for the new design. Prior to the implementation of the present system, the beam-loss monitor system was disabled during collider operation and protection of the Tevatron magnets relied on the quench protection system. The new Beam-Loss Monitor system allows appropriate abort logic and thresholds to be set over the full set of collider operating conditions. The system also records a history of beam-loss data prior to a beam-abort event for post-abort analysis. Installation of the Main Injector system occurred in the fall of 2006 and the Tevatron system in the summer of 2007. Both systems were fully operation by the summer of 2008. In this paper we report on the overall system design, provide a description of its normal operation, and show a number of examples of its use in both the Main Injector and Tevatron.

  7. PTEN loss and p27 loss differ among morphologic patterns of prostate cancer, including cribriform.

    Science.gov (United States)

    Ronen, Shira; Abbott, Daniel W; Kravtsov, Oleksandr; Abdelkader, Amrou; Xu, Yayun; Banerjee, Anjishnu; Iczkowski, Kenneth A

    2017-07-01

    The presence and extent of cribriform pattern of prostate cancer portend recurrence and cancer death. The relative expressions within this morphology of the prognostically adverse loss of PTEN, and the downstream inactivation of cell cycle inhibitor p27/Kip1 had been uncertain. In this study, we examined 52 cases of cribriform cancer by immunohistochemistry for PTEN, p27, and CD44 variant (v)7/8, and a subset of 17 cases by chromogenic in situ hybridization (ISH) using probes for PTEN or CDKN1B (gene for p27). The fractions of epithelial pixels positive by immunohistochemistry and ISH were digitally assessed for benign acini, high-grade prostatic intraepithelial neoplasia, and 8 morphologic patterns of cancer. Immunostaining results demonstrated that (1) PTEN loss was significant for fused small acini, cribriform-central cells, small cribriform acini, and Gleason grade 5 cells in comparison with other acini; (2) p27 loss was significant only for cribriform-peripheral cells and borderline significant for fused small acini in comparison with benign acini; and (3) CD44v7/8 showed expression loss in cribriform-peripheral cells; other comparisons were not significant. ISH showed that cribriform cancer had significant PTEN loss normalized to benign acini (PPTEN or p27 loss as prognostic factors demands distinct assessment in the varieties of Gleason 4 cancer, and in the biphenotypic peripheral versus central populations in cribriform structures. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Beam Loss Simulation and Collimator System Configurations for the Advanced Photon Source Upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Xiao, A.; Borland, M.

    2017-06-25

    The proposed multi-bend achromat lattice for the Advanced Photon Source upgrade (APS-U) has a design emittance of less than 70 pm. The Touschek loss rate is high: compared with the current APS ring, which has an average beam lifetime ~ 10 h, the simulated beam lifetime for APS-U is only ~2 h when operated in the high flux mode (I=200 mA in 48 bunches). An additional consequence of the short lifetime is that injection must be more frequent, which provides another potential source of particle loss. In order to provide information for the radiation shielding system evaluation and to avoid particle loss in sensitive locations around the ring (for example, insertion device straight sections), simulations of the detailed beam loss distribution have been performed. Several possible collimation configurations have been simulated and compared.

  9. An approach to fundamental study of beam loss minimization

    International Nuclear Information System (INIS)

    Jameson, R.A.

    1999-01-01

    The accelerator design rules involving rms matching, developed at CERN in the 1970's, are discussed. An additional rule, for equipartitioning the beam energy among its degrees of freedom, may be added to insure an rms equilibrium conditions. If the strong stochasticity threshold is avoided, as it is in realistic accelerator designs, the dynamics is characterized by extremely long transient settling times, making the role of equipartitioning hard to explain. An approach to systematic study using the RFQ accelerator as a simulation testbed is discussed. New methods are available from recent advances in research on complexity, nonlinear dynamics, and chaos

  10. Magnetic field shielding by vacuum chambers of magnetic material for beam loss reduction

    International Nuclear Information System (INIS)

    Kamiya, Junichiro; Ogiwara, Norio; Hayashi, Naoki; Hotchi, Hideaki; Yoshimoto, Masahiro; Kinsho, Michikazu

    2012-01-01

    One of the reasons of a beam loss in a high power accelerator is leakage magnetic field from a magnet at a close beam line, which distorts the beam orbit and makes the beam hit the wall of the beam pipe. The most effective way to shield such leakage field is to cover the beam by the magnetic materials at the nearest space. This means that beam pipes and bellows be made of the magnetic materials. We plan to apply this method to the vacuum chambers of the beam extraction section of the J-PARC 3 GeV synchrotron, where the effect of the leakage magnetic field to the beam orbit is evident. However, there is few proven evidence of the vacuum chambers made of magnetic materials. Therefore we clarify the problems in producing beam pipes and bellows, which satisfy the magnetic and vacuum performance. In this article, we deliver the over view of the magnetic shielding project and our approaches to the problems in producing the vacuum chambers of magnetic materials. (author)

  11. Prestress Loss of CFL in a Prestressing Process for Strengthening RC Beams

    Directory of Open Access Journals (Sweden)

    Xinyan Guo

    2017-01-01

    Full Text Available A prestressing system was designed to strengthen reinforced concrete (RC beams with prestressed carbon fiber laminate (CFL. During different prestressing processes, prestress loss was measured using strain gauges attached on the surface of CFL along the length direction. The prestress loss was 50–68% of the whole prestress loss, which is typically associated with CFL slipping between the grip anchors. Approximately 20–27% of the prestress loss was caused by the elastic shortening of the RC beam. An analytical model using linear-elastic theory was constructed to calculate the prestress loss caused by CFL slipping between the anchors and the elastic shortening of the strengthened beams. The compared results showed that the analytical model of prestress loss can describe the experimental data well. Methods of reducing the prestress loss were also suggested. Compared to other experiments, the prestressing system proposed by this research group was effective because the maximum percentage of prestress loss was 14.9% and the average prestress loss was 12.5%.

  12. Shielding NSLS-II light source: Importance of geometry for calculating radiation levels from beam losses

    Science.gov (United States)

    Kramer, S. L.; Ghosh, V. J.; Breitfeller, M.; Wahl, W.

    2016-11-01

    Third generation high brightness light sources are designed to have low emittance and high current beams, which contribute to higher beam loss rates that will be compensated by Top-Off injection. Shielding for these higher loss rates will be critical to protect the projected higher occupancy factors for the users. Top-Off injection requires a full energy injector, which will demand greater consideration of the potential abnormal beam miss-steering and localized losses that could occur. The high energy electron injection beam produces significantly higher neutron component dose to the experimental floor than a lower energy beam injection and ramped operations. Minimizing this dose will require adequate knowledge of where the miss-steered beam can occur and sufficient EM shielding close to the loss point, in order to attenuate the energy of the particles in the EM shower below the neutron production threshold (Designing supplemental shielding near the loss point using the analytic shielding model is shown to be inadequate because of its lack of geometry specification for the EM shower process. To predict the dose rates outside the tunnel requires detailed description of the geometry and materials that the beam losses will encounter inside the tunnel. Modern radiation shielding Monte-Carlo codes, like FLUKA, can handle this geometric description of the radiation transport process in sufficient detail, allowing accurate predictions of the dose rates expected and the ability to show weaknesses in the design before a high radiation incident occurs. The effort required to adequately define the accelerator geometry for these codes has been greatly reduced with the implementation of the graphical interface of FLAIR to FLUKA. This made the effective shielding process for NSLS-II quite accurate and reliable. The principles used to provide supplemental shielding to the NSLS-II accelerators and the lessons learned from this process are presented.

  13. Global patterns in mangrove soil carbon stocks and losses

    Science.gov (United States)

    Atwood, Trisha B.; Connolly, Rod M.; Almahasheer, Hanan; Carnell, Paul E.; Duarte, Carlos M.; Ewers Lewis, Carolyn J.; Irigoien, Xabier; Kelleway, Jeffrey J.; Lavery, Paul S.; Macreadie, Peter I.; Serrano, Oscar; Sanders, Christian J.; Santos, Isaac; Steven, Andrew D. L.; Lovelock, Catherine E.

    2017-07-01

    Mangrove soils represent a large sink for otherwise rapidly recycled carbon (C). However, widespread deforestation threatens the preservation of this important C stock. It is therefore imperative that global patterns in mangrove soil C stocks and their susceptibility to remineralization are understood. Here, we present patterns in mangrove soil C stocks across hemispheres, latitudes, countries and mangrove community compositions, and estimate potential annual CO2 emissions for countries where mangroves occur. Global potential CO2 emissions from soils as a result of mangrove loss were estimated to be ~7.0 Tg CO2e yr-1. Countries with the highest potential CO2 emissions from soils are Indonesia (3,410 Gg CO2e yr-1) and Malaysia (1,288 Gg CO2e yr-1). The patterns described serve as a baseline by which countries can assess their mangrove soil C stocks and potential emissions from mangrove deforestation.

  14. Global patterns in mangrove soil carbon stocks and losses

    KAUST Repository

    Atwood, Trisha B.

    2017-06-26

    Mangrove soils represent a large sink for otherwise rapidly recycled carbon (C). However, widespread deforestation threatens the preservation of this important C stock. It is therefore imperative that global patterns in mangrove soil C stocks and their susceptibility to remineralization are understood. Here, we present patterns in mangrove soil C stocks across hemispheres, latitudes, countries and mangrove community compositions, and estimate potential annual CO2 emissions for countries where mangroves occur. Global potential CO2 emissions from soils as a result of mangrove loss were estimated to be ~7.0 Tg CO2e yr−1. Countries with the highest potential CO2 emissions from soils are Indonesia (3,410 Gg CO2e yr−1) and Malaysia (1,288 Gg CO2e yr−1). The patterns described serve as a baseline by which countries can assess their mangrove soil C stocks and potential emissions from mangrove deforestation.

  15. Off-momentum loss maps with one beam

    CERN Document Server

    Garcia Morales, Hector; Salvachua Ferrando, Belen Maria; CERN. Geneva. ATS Department

    2016-01-01

    The aim of this MD is the benchmarking of simulation of off-momentum loss maps. This will help us to further understand the dynamics of the off-momentum collimation cleaning and give input to the determination of the operational settings of the off-momentum cleaning insertion. The MD was carried out during different end-of-fills of other MDs. In this note we summarize the procedures and the measurements taken during the MD week.

  16. Simulation study on beam loss in the alpha bucket regime during SIS-100 proton operation

    Science.gov (United States)

    Sorge, S.

    2018-02-01

    Crossing the transition energy γt in synchrotrons for high intensity proton beams requires well tuned jump schemes and is usually accompanied by longitudinal emittance growth. In order to avoid γt crossing during proton operation in the projected SIS-100 synchrotron special high-γt lattice settings have been developed, in order to keep γt above the beam extraction energy. A further advantage of this scheme is the formation of alpha buckets which naturally lead to short proton bunches, required for the foreseen production and storage of antiprotons for the FAIR facility. Special attention is turned on the imperfections of the superconducting SIS-100 magnets because together with the high-γt lattice settings, they could potentially lead to enhanced beam loss. The aim of the present work is to estimate the beam loss by means of particle tracking simulations.

  17. Study of Acquisition Electronics with a High Dynamic Range for a Beam Loss Measurement System

    CERN Document Server

    Venturini, G; Dehning, B; Effinger, E

    2010-01-01

    The particles accelerated in CERN accelerator chain reach high energies, topped by the particle energy at collision in the LHC, 7 GeV. During the operation, an amount of particles is inevitably lost from the beam. Depending on the extent of the losses, physical damage to machine components may be caused and the shower of secondary emission particles deposits energy in the surrounding equipment constituting the accelerator. The hadronic cascade also activates their materials, representing a hazard to the workers at CERN. In the LHC, the superconducting magnets that constitute the synchrotron lattice are kept at an operating temperature of 1:9K through a cryogenic facility employing superliquid helium, the increase in their temperature potentially initiates a quench. In the SPS, the damage due to a lost beam is also visible. The Beam Loss Monitoring (BLM) system has been developed to reliably protect the machines composing CERN’s accelerator chain and additionally provide information about the beam status: th...

  18. Comparison of measurements and modeling of beam ion loss during TAE avalanches in NSTX

    Science.gov (United States)

    Darrow, Douglass; Crocker, N.; Fredrickson, E.; Gorelenkov, N.; Podesta, M.; Shi, L.; White, R.

    2011-10-01

    Brief `avalanches' of toroidal Alfvén eigenmodes (TAEs) are observed in NSTX plasmas having several different n numbers simultaneously present. All are accompanied by a drop in the neutron rate, indicating likely loss of beam ions. However, the scintillator fast ion loss detector at the wall on NSTX registers losses only for some avalanches and not others. When losses are seen, they cover a wide range of pitch angles, suggesting that the modes cause stochasticity in the beam ion phase space. A 16 channel array of microwave reflectometers provides a radial profile of the structure of each n TAE, which can then be used to produce an absolute amplitude for a TAE mode structure computed by the NOVA code for the plasma at the time of interest. Using the equilibrium plus the TAE modes structures in the guiding center code ORBIT then allows modeling of the effect of the avalanches on beam ion orbits. The modeling does reveal stochastic behavior and loss of some classes of orbits that are populated by the neutral beams on NSTX, with an amplitude threshold for loss that is close to that observed in the experiments. This work supported by US DoE contract DE-ACO2-09CH11466 and the China Scholarship Council.

  19. Daily pattern of energy distribution and weight loss.

    Science.gov (United States)

    Raynor, Hollie A; Li, Fan; Cardoso, Chelsi

    2018-02-19

    Timing of energy intake, a temporal dietary pattern, may enhance health. Eating a greater amount of energy earlier and a smaller amount of energy later in the day, a behavioral circadian rhythm, may assist with chronoenhancement. Chronoenhancement seeks to enhance entrainment (synchronization) of biological and behavioral circadian rhythms. In humans, research reports that eating a greater amount of energy early and a smaller amount of energy later in the day increases dietary induced thermogenesis, improves cardiometabolic outcomes, and enhances weight loss. However, little human research has examined if this eating pattern enhances regularity of biological circadian rhythm. In a randomized controlled 8-week pilot study, the influence of energy distribution timing on weight loss and regularity of sleep onset and wake times (marker for biological circadian rhythm) was examined. Within an hypocaloric, three-meal prescription, participants (n = 8) were assigned to either: 1) Morning: 50%, 30%, and 20% of kcal at breakfast, lunch, and dinner, respectively; or 2) Evening: 20%, 30%, and 50% of kcal at breakfast, lunch, and dinner, respectively. Percent weight loss and regularity of sleep onset and wake times were significantly (p energy distribution timing on health, longer studies conducted in free-living participants, with dietary intake assessed using time-stamped methods, that include measures of the circadian timing system are needed. This small review is based upon a symposium presentation at the Society of the Study of Ingestive Behavior in 2017. Copyright © 2018 Elsevier Inc. All rights reserved.

  20. Beam loss studies on silicon strip detector modules for the CMS experiment

    CERN Document Server

    Fahrer, Manuel

    2006-01-01

    The large beam energy of the LHC demands for a save beam abort system. Nevertheless, failures cannot be excluded with last assurance and are predicted to occur once per year. As the CMS experiment is placed in the neighboured LHC octant, it is affected by such events. The effect of an unsynchronized beam abort on the silicon strip modules of the CMS tracking detector has been investigated in this thesis by performing one accelerator and two lab experiments. The dynamical behaviour of operational parameters of modules and components has been recorded during simulated beam loss events to be able to disentangle the reasons of possible damages. The first study with high intensive proton bunches at the CERN PS ensured the robustness of the module design against beam losses. A further lab experiment with pulsed IR LEDs clarified the physical and electrical processes during such events. The silicon strip sensors on a module are protected against beam losses by a part of the module design that originally has not been...

  1. System Architecture for measuring and monitoring Beam Losses in the Injector Complex at CERN

    CERN Document Server

    Zamantzas, C; Dehning, B; Jackson, S; Kwiatkowski, M; Vigano, W

    2012-01-01

    The strategy for beam setup and machine protection of the accelerators at the European Organisation for Nuclear Research (CERN) is mainly based on its Beam Loss Monitoring (BLM) systems. For their upgrade to higher beam energies and intensities, a new BLM system is under development with the aim of providing faster measurement updates with higher dynamic range and the ability to accept more types of detectors as input compared to its predecessors. In this paper, the architecture of the complete system is explored giving an insight to the design choices made to provide a highly reconfigurable system that is able to fulfil the different requirements of each accelerator using reprogrammable devices.

  2. Design for low beam loss in accelerators for intense neutron source applications

    International Nuclear Information System (INIS)

    Jameson, R.A.

    1993-01-01

    Control of beam loss in intense ion linacs involves keeping beam spill below parts in 10 -5 --10 -8 /m by preventing total beam size from extending to the limiting apertures. Starting from good rms design practices, new analysis of the machine architecture is described in terms of the effects of the machine tune with space-charge, free-energy constraint, and halo-producing mechanisms. It is shown that halos are produced by the time- (or position-) varying nature of common linac aspects (such as misalignment, mismatching, acceleration, and construction techniques) through collective core/single-particle interaction dynamics plus resonances

  3. 5% Minoxidil: treatment for female pattern hair loss.

    Science.gov (United States)

    Gupta, Aditya K; Foley, Kelly A

    2014-01-01

    Minoxidil is a Health Canada and US FDA-approved medication for hair loss in men and women. While 5% minoxidil foam has been approved for men since 2006, Health Canada and the FDA only approved 5% minoxidil foam for female pattern hair loss (FPHL) in 2014. Recent Phase III clinical trials demonstrated the efficacy of once daily 5% minoxidil foam for treatment of FPHL, where a significant change from baseline in the target area hair count was observed compared to placebo. Similar changes in hair count for 5% foam and twice daily 2% minoxidil solution established noninferiority of the 5% foam formulation. Five percent minoxidil foam provides an additional option for women with FPHL and will soon be available in Canada.

  4. Comparison of measured and computed loss to parasitic modes in cylindrical cavities with beam ports

    International Nuclear Information System (INIS)

    Wilson, P.B.; Styles, J.B.; Bane, K.L.F.

    1977-03-01

    Good agreement was obtained between computed values and results from a bench measurement technique for the total loss to parasitic modes in several cylindrical cavities with beam ports. The measurement of loss as a function of time within the current pulse also gives results which are in good agreement with computed functions, especially considering the fact that there are questionable points concerning both the theory and the measurement technique. Within measurement errors, there is also agreement in a few cases where a comparison is possible between a bench measurement result and the heating produced directly in a component by the SPEAR beam

  5. Cavity loss factors of non-relativistic beams for Project X

    Energy Technology Data Exchange (ETDEWEB)

    Lunin, A.; Yakovlev, V.; Kazakov, S.; /Fermilab

    2011-03-01

    Cavity loss factor calculation is an important part of the total cryolosses estimation for the super conductive (SC) accelerating structures. There are two approaches how to calculate cavity loss factors, the integration of a wake potential over the bunch profile and the addition of loss factors for individual cavity modes. We applied both methods in order to get reliable results for non-relativistic beam. The time domain CST solver was used for a wake potential calculation and the frequency domain HFSS code was used for the cavity eigenmodes spectrum findings. Finally we present the results of cavity loss factors simulations for a non-relativistic part of the ProjectX and analyze it for various beam parameters.

  6. Very Fast Losses of the Circulating LHC Beam, their Mitigation and Machine Protection

    CERN Document Server

    Baer, Tobias; Elsen, Eckhard

    The Large Hadron Collider (LHC) has a nominal energy of 362MJ stored in each of its two counter-rotating beams - over two orders of magnitude more than any previous accelerator and enough to melt 880kg of copper. Therefore, in case of abnormal conditions comprehensive machine protection systems extract the beams safely from the LHC within not more than three turns $\\approx$270$\\mu$s. The first years of LHC operation demonstrated a remarkable reliability of the major machine protection systems. However, they also showed that the LHC is vulnerable to losses of the circulating beams on very fast timescales, which are too fast to ensure an active protection. Very fast equipment failures, in particular of normal-conducting dipole magnets and the transverse damper can lead to such beam losses. Whereas these failures were already studied in the past, other unexpected beam loss mechanisms were observed after the LHC start-up: so-called (un)identified falling objects (UFOs), which are believed to be micrometer-sized m...

  7. Contrast of HOLZ lines in energy-filtered convergent-beam electron diffraction patterns from silicon

    International Nuclear Information System (INIS)

    Lehmpfuhl, G.; Krahl, D.; Uchida, Y.

    1995-01-01

    Higher-order Laue-zone (HOLZ) lines were investigated in convergent-beam electron diffraction patterns from silicon near the low-indexed zone axes [100], [110] and [111]. The visibility of these lines depends on the effective structure potentials of the reflections from the first Laue zone depending on their Debye-Waller factor. The contrast of the HOLZ lines is strongly reduced by inelastically scattered electrons. They can be excluded by an imaging Ω filter for energy losses above 2 eV. The diffraction patterns were compared with many-beam calculations. Without absorption, an excellent agreement could be achieved for the [111] and [100] zone axes, while the simulation of the [110] zone-axis pattern needed a calculation with absorption. The reason for this observation is explained in the Bloch-wave picture. Calculations with absorption, however, lead to artefacts in the intensity distribution of the [100] HOLZ pattern. In order to obtain agreement with the experiment, the Debye-Waller factor had to be modified in different ways for the different zone axes. This corresponds to a strong anisotropy of the Debye-Waller factor. To confirm this observation, the temperature dependence of the itensity distributions of the HOLZ patterns was investigated between 50 and 680 K. At room temperature, the parameter D in the Debye-Waller factor exp(-Ds 2 ) was determined as 0.13, 0.26 and 0.55 A 2 for the zone axes [100], [111] and [110], respectively. The reliability of the conclusions is discussed. (orig.)

  8. An FPGA Based Implementation for Real-Time Processing of the LHC Beam Loss Monitoring System's Data

    CERN Document Server

    Dehning, B; Emery, J; Ferioli, G; Zamantzas, C

    2006-01-01

    The strategy for machine protection and quench prevention of the Large Hadron Collider (LHC) at the European Organisation for Nuclear Research (CERN) is mainly based on the Beam Loss Monitoring (BLM) system. At each turn, there will be several thousands of data to record and process in order to decide if the beams should be permitted to continue circulating or their safe extraction is necessary to be triggered. The processing involves a proper analysis of the loss pattern in time and for the decision the energy of the beam needs to be accounted. This complexity needs to be minimized by all means to maximize the reliability of the BLM system and allow a feasible implementation. In this paper, a field programmable gate array (FPGA) based implementation is explored for the real-time processing of the LHC BLM data. It gives emphasis on the highly efficient Successive Running Sums (SRS) technique used that allows many and long integration periods to be maintained for each detector's data with relatively small leng...

  9. Design and Development of a Diagnostics Client for a Beam Loss Measurement System at CERN

    CERN Document Server

    Angelogiannopoulos, Emmanouil; Jackson, Stephen

    The European Organization for Nuclear Research, known as CERN, is one of the biggest research centers in the field of particle physics. Its main function is to provide particle accelerators and other infrastructure needed for high energy physics research. Particles are accelerated through a complex of accelerators and are brought into collision, in order to study the fundamental elements of matter and the forces acting between them. Of course, such complex and expensive machines need control and protection. For that purpose, a variety of different systems -hardware and/or software- is needed. One such system is the Beam Loss Monitoring (BLM) system of an accelerator. This kind of system is designed for measuring beam losses around an accelerator. An appropriate design of the BLM system and an appropriate location of the monitors enable a wide field of very useful beam diagnostics and machine protection possibilities. This thesis focuses on the design and development of a client application, which is realized ...

  10. Heavy ion beam loss mechanisms at an electron-ion collider

    Directory of Open Access Journals (Sweden)

    Spencer R. Klein

    2014-12-01

    Full Text Available There are currently several proposals to build a high-luminosity electron-ion collider, to study the spin structure of matter and measure parton densities in heavy nuclei, and to search for gluon saturation and new phenomena like the colored glass condensate. These measurements require operation with heavy nuclei. We calculate the cross sections for two important processes that will affect accelerator and detector operations: bound-free pair production and Coulomb excitation of the nuclei. Both of these reactions have large cross sections, 28–56 mb, which can lead to beam ion losses, produce beams of particles with altered charge:mass ratio, and produce a large flux of neutrons in zero degree calorimeters. The loss of beam particles limits the sustainable electron-ion luminosity to levels of several times 10^{32}/cm^{2}/s.

  11. Recognizing patterns of visual field loss using unsupervised machine learning

    Science.gov (United States)

    Yousefi, Siamak; Goldbaum, Michael H.; Zangwill, Linda M.; Medeiros, Felipe A.; Bowd, Christopher

    2014-03-01

    Glaucoma is a potentially blinding optic neuropathy that results in a decrease in visual sensitivity. Visual field abnormalities (decreased visual sensitivity on psychophysical tests) are the primary means of glaucoma diagnosis. One form of visual field testing is Frequency Doubling Technology (FDT) that tests sensitivity at 52 points within the visual field. Like other psychophysical tests used in clinical practice, FDT results yield specific patterns of defect indicative of the disease. We used Gaussian Mixture Model with Expectation Maximization (GEM), (EM is used to estimate the model parameters) to automatically separate FDT data into clusters of normal and abnormal eyes. Principal component analysis (PCA) was used to decompose each cluster into different axes (patterns). FDT measurements were obtained from 1,190 eyes with normal FDT results and 786 eyes with abnormal (i.e., glaucomatous) FDT results, recruited from a university-based, longitudinal, multi-center, clinical study on glaucoma. The GEM input was the 52-point FDT threshold sensitivities for all eyes. The optimal GEM model separated the FDT fields into 3 clusters. Cluster 1 contained 94% normal fields (94% specificity) and clusters 2 and 3 combined, contained 77% abnormal fields (77% sensitivity). For clusters 1, 2 and 3 the optimal number of PCA-identified axes were 2, 2 and 5, respectively. GEM with PCA successfully separated FDT fields from healthy and glaucoma eyes and identified familiar glaucomatous patterns of loss.

  12. The LHC beam loss monitoring system's real-time data analysis card

    CERN Document Server

    Dehning, B; Ferioli, G; Guaglio, G; Leitner, R; Zamantzas, C

    2005-01-01

    The BLM (Beam Loss Monitoring) system has to prevent the superconducting magnets from being quenched and protect the machine components against damages making it one of the most critical elements for the protection of the LHC. The complete system consists of 3600 detectors, placed at various locations around the ring, tunnel electronics, which are responsible for acquiring, digitizing, and transmitting the data, and surface electronics, which receive the data via 2km optical data links, process, analyze, store, and issue warning and abort triggers. At those surface units, named BLMTCs, the backbone on each of them is an FPGA (field programmable gate array) which treats the loss signals collected from 16 detectors. It takes into account the beam energy and keeps 192 running sums giving loss durations of up to the last 84 seconds before it compares them with thresholds uniquely programmable for each detector. In this paper, the BLMTC's design is explored giving emphasis to the strategies followed in combining t...

  13. Background gas density and beam losses in NIO1 beam source

    Energy Technology Data Exchange (ETDEWEB)

    Sartori, E., E-mail: emanuele.sartori@igi.cnr.it; Veltri, P.; Serianni, G. [Consorzio RFX (CNR, ENEA, INFN, Università di Padova, Acciaierie Venete SpA), C.so Stati Uniti 4, 35127 Padova (Italy); Cavenago, M. [INFN-LNL, v.le dell’Università 2, I-35020 Legnaro (PD) (Italy)

    2016-02-15

    NIO1 (Negative Ion Optimization 1) is a versatile ion source designed to study the physics of production and acceleration of H- beams up to 60 keV. In ion sources, the gas is steadily injected in the plasma source to sustain the discharge, while high vacuum is maintained by a dedicated pumping system located in the vessel. In this paper, the three dimensional gas flow in NIO1 is studied in the molecular flow regime by the Avocado code. The analysis of the gas density profile along the accelerator considers the influence of effective gas temperature in the source, of the gas temperature accommodation by collisions at walls, and of the gas particle mass. The calculated source and vessel pressures are compared with experimental measurements in NIO1 during steady gas injection.

  14. Residual activity induced by heavy ions and beam-loss criteria for heavy-ion accelerators

    Directory of Open Access Journals (Sweden)

    I. Strašík

    2010-07-01

    Full Text Available The paper presents results of FLUKA simulations of the residual activity induced by heavy ions in two target configurations representing: (1 a beam pipe of an accelerator and (2 a bulky accelerator structure like a magnet yoke or a coil. The target materials were stainless steel and copper representing the most common construction materials used for basic accelerator components. For these two materials, the inventory of the induced isotopes depends mainly on the target material and much less on the projectile species. Time evolution of the induced activity can be described by means of a generic curve that is independent from the projectile mass. Dependence of the induced residual activity on selected ion beam parameters was studied. The main goal of the study was establishing a scaling law expanding the existing proton beam-loss tolerance to heavy-ion beams. This scaling law enables specifying beam-loss criteria for projectile species from proton up to uranium at energies from 200  MeV/u up to 1  GeV/u.

  15. Simulation of the ATLAS SCT barrel module response to LHC beam loss scenarios

    CERN Document Server

    Rose, P; The ATLAS collaboration; Fadeyev, V; Spencer, E; Wilder, M; Domingo, M

    2014-01-01

    In the event of beam loss at the LHC, ATLAS Inner Detector components nearest the beam line may be subjected to unusually large amounts of radiation. Understanding their behavior in such an event is important in determining whether they would still function properly. We built a SPICE model of the silicon strip module electrical system to determine the behavior of its elements during a realistic beam loss scenario. We found that the power supply and bias filter characteristics strongly affect the module response in such scenarios. In particular, the following self-limiting phenomena were observed: there is a finite amount of charge initially available on the bias filter capacitors for collection by the strips; the power supply current limit reduces the rate at which the bias filter capacitors' charge can be replenished; the reduced bias voltage leads to a smaller depletion depth in the sensors which results in less collected charge. These effects provide a larger measure of safety during beam loss events than ...

  16. Evaluation of Beam Losses and Energy Depositions for a Possible Phase II Design for LHC Collimation

    CERN Document Server

    Lari, L; Bracco, C; Brugger, M; Cerutti, F; Doyle, E; Ferrari, A; Keller, L; Lundgren, S; Keller, L; Mauri, M; Redaelli, S; Sarchiapone, L; Smith, J; Vlachoudis, V; Weiler, T

    2008-01-01

    The LHC beams are designed to have high stability and to be stored for many hours. The nominal beam intensity lifetime is expected to be of the order of 20h. The Phase II collimation system has to be able to handle particle losses in stable physics conditions at 7 TeV in order to avoid beam aborts and to allow correction of parameters and restoration to nominal conditions. Monte Carlo simulations are needed in order to evaluate the behavior of metallic high-Z collimators during operation scenarios using a realistic distribution of losses, which is a mix of the three limiting halo cases. Moreover, the consequences in the IR7 insertion of the worst (case) abnormal beam loss are evaluated. The case refers to a spontaneous trigger of the horizontal extraction kicker at top energy, when Phase II collimators are used. These studies are an important input for engineering design of the collimation Phase II system and for the evaluation of their effect on adjacent components. The goal is to build collimators that can ...

  17. Duration of memory loss due to electron beam exposure. Final report Jan-May 1983

    Energy Technology Data Exchange (ETDEWEB)

    Wheeler, T.G.; Tilton, B.M.

    1983-08-01

    Electron beam exposure has been shown to produce retrograde amnesia (RA). The objective of this study was to determine the duration of memory loss upon electron beam exposure. It is important to know if exposure produces a memory loss of the events which occurred in the preceding 1 sec or memory loss of the preceding minute's events. The task was a single-trial avoidance paradigm. The animal was placed in a small aversive chamber. After a 90-sec adaptation period, a door opened that provided access to a large, dark, preferred chamber. The time required for the animal to enter the preferred chamber was the measure of interest (T). Once inside the preferred chamber, a 1-sec footshock was delivered. Following the footshock by some preset delay (delta T), the animal was exposed to a 10-microsec, 10-rad electron beam (or X-ray). A second trial on the task was run 2 hr postexposure. The second trial consisted of placing the animal in the aversive chamber and monitoring the time (T') required to enter the preferred chamber. If the electron beam exposure interfered with the animal's ability to recall the shock, T' would be greatly reduced as compared with the sham controls. The exposure delay times used were delta T = 1, 3, 5, and 10 sec.

  18. Low-beam-loss design of a compact, high-current deuteron radio frequency quadrupole accelerator

    Directory of Open Access Journals (Sweden)

    C. Zhang

    2004-10-01

    Full Text Available A 201.5 MHz, 50 mA, 2.0 MeV deuteron radio frequency quadrupole accelerator is proposed as the neutron generator for the neutron experiment facility project at Peking University, China. Based on better understanding of beam losses, some new optimization procedures concerning both longitudinal and transverse dynamics are adopted. Accordingly, the beam transmission efficiency is improved from 91.2% to 98.3% and the electrode length is shortened from 2.91 to 2.71 m. The fundamental physical analyses are performed to look inside the new design recipe and explain why it works.

  19. External Beam Radiotherapy for Colon Cancer: Patterns of Care

    International Nuclear Information System (INIS)

    Dunn, Emily F.; Kozak, Kevin R.; Moody, John S.

    2010-01-01

    Purpose: Despite its common and well characterized use in other gastrointestinal malignancies, little is known about radiotherapy (RT) use in nonmetastatic colon cancer in the United States. To address the paucity of data regarding RT use in colon cancer management, we examined the RT patterns of care in this patient population. Methods and Materials: Patients with nonmetastatic colon cancer, diagnosed between 1988 and 2005, were identified in the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate methods were used to identify factors associated with RT use. Results: On univariate analysis, tumor location, age, sex, race, T stage, N stage, and geographic location were each associated with differences in RT use (all p < 0.01). In general, younger patients, male patients, and patients with more advanced disease were more likely to receive RT. On multivariate analysis, tumor location, age, gender, T and N stage, time of diagnosis and geographic location were significantly associated with RT use (all p < 0.001). Race, however, was not associated with RT use. On multivariate analysis, patients diagnosed in 1988 were 2.5 times more likely to receive RT than those diagnosed in 2005 (p = 0.001). Temporal changes in RT use reflect a responsiveness to evolving evidence related to the therapeutic benefits of adjuvant RT. Conclusions: External beam RT is infrequently used for colon cancer, and its use varies according to patient and tumor characteristics. RT use has declined markedly since the late 1980s; however, it continues to be used for nonmetastatic disease in a highly individualized manner.

  20. Allotropic effects on the energy loss of swift H+ and He+ ion beams through thin foils

    International Nuclear Information System (INIS)

    Garcia-Molina, Rafael; Abril, Isabel; Denton, Cristian D.; Heredia-Avalos, Santiago

    2006-01-01

    We have developed a theoretical treatment and a simulation code to study the energy loss of swift H + and He + ion beams interacting with thin foils of different carbon allotropes. The former is based on the dielectric formalism, and the latter combines Monte Carlo with the numerical solution of the motion equation for each projectile to describe its trajectory and interactions through the target. The capabilities of both methods are assessed by the reasonably good agreement between their predictions and the experimental results, for a wide range of projectile energies and target characteristics. Firstly, we apply the theoretical procedure to calculate the stopping cross sections for H + and He + beams in foils of different allotropic forms of carbon (such as diamond, graphite, amorphous carbon, glassy carbon and C 60 -fullerite), as a function of the projectile energy. We take into account the electronic structure of the projectile, as well as the different charge states it can acquire, the energy loss associated to the electronic capture and loss processes, the polarization of the projectile, and a realistic description of the target. On the other hand, the simulation code is used to evaluate the energy distributions of swift H + and He + ion beams when traversing several foils of the above mentioned allotropic forms of carbon, in order to analyze the influence of the chemical and physical state of the target in the projectile energy loss. These allotropic effects are found to become more important around the maximum of the stopping cross-section

  1. Propagation and Loss-Cone Properties of Relativistic Electron Beams in the Magnetosphere

    Science.gov (United States)

    Sanchez, E. R.; Powis, A.; Greklek, M.; Porazik, P.; Kaganovich, I.

    2017-12-01

    One of the main obstacles for achieving closure of several key outstanding questions in magnetospheric physics has been the lack of accurate magnetic field mapping between processes or regions in the magnetosphere and their ionospheric foot-points. Accurate correspondence between magnetospheric processes or regions and their ionospheric foot-points can be achieved with beams of MeV electrons that propagate along magnetic-field lines in fractions of a second, emitted by compact linear accelerators under controlled conditions at specified points in the magnetosphere, while the atmospheric imprint created by their precipitation is detected by an array of ground-based optical imagers, radars, riometers or X-ray detectors. To prove that successful magnetic field mapping is possible, we must ensure that the beam can be injected into the loss cone, that the spacecraft potentials induced by the beam emission are manageable, that the beam propagates all the way into the topside ionosphere, and that the beam produces a signature detectable from the ground or from low altitude. In this work, we present the latest results of calculations of beam injection and propagation for a wide range of injection distances in the magnetotail equator and geomagnetic conditions to determine under what conditions beams emitted from the magnetosphere would be able to propagate to the topside ionosphere with enough intensity to be detected by ground-based or low-altitude instrumentation. Using ballistic simulations of charged particle motion, we demonstrate that relativistic electron beams can be successfully injected into the loss cone under both ideal (analytic dipole) and realistic (MHD modeled) magnetosphere conditions from a wide range of injection positions. For identical injection coordinates, the impact location on the top of the atmosphere is dependent on the current magnetosphere conditions, demonstrating that this technique can distinguish between the phases of a geomagnetic storm

  2. Controlled Transverse Blow-up of Highenergy Proton Beams for Aperture Measurements and Loss Maps

    CERN Document Server

    Hӧfle, W; Redaelli, S; Schmidt, R; Valuch, D; Wollmann, D; Zerlauth, M

    2012-01-01

    A technique was developed to blow-up transversely in a controlled way high energy proton beams in the LHC. The technique is based on band limited white noise excitation that is injected into the transverse damper feedback loop. The injected signal can be gated to selectively blow-up individual trains of bunches. The speed of transverse blow-up can be precisely controlled. This opens the possibility to perform safely and efficiently aperture measurements and loss maps with high intensity bunch trains well above stored beam energies that are considered to be safe. In particular, lengthy procedures for measurements at top energy, otherwise requiring multiple fills of individual bunches, can be avoided. In this paper, the method is presented and results from beam measurements are discussed and compared with alternative blowup methods.

  3. Measurements of the relative sensitivities between some beam-loss monitors, PART II

    CERN Document Server

    Bosser, Jacques; CERN. Geneva. SPS and LEP Division

    1998-01-01

    We measured the relative sensitivity of various types of classical beam-loss monitors following on from and in the spirit of a previous work. The detectors were tested in one of the SPS extraction l ines. The particles passing through the line consist of 2/3 protons and 1/3 pions at 120 Gev/c. The low extracted (spill time 2.5 s) beam intensity can be adjusted. Upstream of the detectors a copp er target (diameter: 7 cm, length: 50 cm) can be placed on the beam axis. First we proceed with linearity and sensitivity measurements of various types of detectors used in counting or analog mode. Next, with a view to increasing the dynamic range we pursue out tests with a dedicated type of electronics. Finally, measurements have been made in order to determine, in the frame of our experiment , the minimum detection level of some monitors.

  4. The requirements for the future e-beam mask writer: statistical analysis of pattern accuracy

    Science.gov (United States)

    Lee, Sang Hee; Choi, Jin; Kim, Hee Bom; Kim, Byung Gook; Cho, Han-Ku

    2011-11-01

    As semiconductor features shrink in size and pitch, the extreme control of CD uniformity, MTT and image placement is needed for mask fabrication with e-beam lithography. Among the many sources of CD and image placement error, the error resulting from e-beam mask writer becomes more important than before. CD and positioning error by e-beam mask writer is mainly related to the imperfection of e-beam deflection accuracy in optic system and the charging and contamination of column. To avoid these errors, the e-beam mask writer should be designed taking into account for these effects. However, the writing speed is considered for machine design with the highest priority, because the e-beam shot count is increased rapidly due to design shrink and aggressive OPC. The increment of shot count can make the pattern shift problem due to statistical issue resulting from e-beam deflection error and the total shot count in layout. And it affects the quality of CD and image placement too. In this report, the statistical approach on CD and image placement error caused by e-beam shot position error is presented. It is estimated for various writing conditions including the intrinsic e-beam positioning error of VSB writer. From the simulation study, the required e-beam shot position accuracy to avoid pattern shift problem in 22nm node and beyond is estimated taking into account for total shot count. And the required local CD uniformity is calculated for various e-beam writing conditions. The image placement error is also simulated for various conditions including e-beam writing field position error. Consequently, the requirements for the future e-beam mask writer and the writing conditions are discussed. And in terms of e-beam shot noise, LER caused by exposure dose and shot position error is studied for future e-beam mask writing for 22nm node and beyond.

  5. High resolution acoustic measurement system and beam pattern reconstruction method for bat echolocation emissions.

    Science.gov (United States)

    Gaudette, Jason E; Kloepper, Laura N; Warnecke, Michaela; Simmons, James A

    2014-01-01

    Measurements of the transmit beam patterns emitted by echolocating bats have previously been limited to cross-sectional planes or averaged over multiple signals using sparse microphone arrays. To date, no high-resolution measurements of individual bat transmit beams have been reported in the literature. Recent studies indicate that bats may change the time-frequency structure of their calls depending on the task, and suggest that their beam patterns are more dynamic than previously thought. To investigate beam pattern dynamics in a variety of bat species, a high-density reconfigurable microphone array was designed and constructed using low-cost ultrasonic microphones and custom electronic circuitry. The planar array is 1.83 m wide by 1.42 m tall with microphones positioned on a 2.54 cm square grid. The system can capture up to 228 channels simultaneously at a 500 kHz sampling rate. Beam patterns are reconstructed in azimuth, elevation, and frequency for visualization and further analysis. Validation of the array measurement system and post-processing functions is shown by reconstructing the beam pattern of a transducer with a fixed circular aperture and comparing the result with a theoretical model. To demonstrate the system in use, transmit beam patterns of the big brown bat, Eptesicus fuscus, are shown.

  6. FESA class for off-momentum lossmaps and decomposition of beam losses at LHC

    CERN Document Server

    Wyszynski, Michal Jakub; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Valentino, Gianluca; CERN. Geneva. ATS Department

    2016-01-01

    The project consisted of two main parts. The first part was to build a FESA class which would serve as lossmap feedback controller for off-momentum lossmaps, capable of handling 100 Hz BLM data, contrary to existing controller. Thanks to the efficient management RF frequency, beam dumps during this procedure would be avoided and machine availability would improve by shortening the duration of machine validation after technical stops. The second part concerned identification of beam losses at the LHC. It was a continuation of author’s work done as Summer Student project. The aim was to identify issues with the existing losses decomposition matrix for flat top, apply necessary corrections and construct analogous matrix for injection.

  7. Accidental beam loss in superconducting accelerators: Simulations, consequences of accidents and protective measures

    International Nuclear Information System (INIS)

    Drozhdin, A.; Mokhov, N.; Parker, B.

    1994-02-01

    The consequences of an accidental beam loss in superconducting accelerators and colliders of the next generation range from the mundane to rather dramatic, i.e., from superconducting magnet quench, to overheating of critical components, to a total destruction of some units via explosion. Specific measures are required to minimize and eliminate such events as much as practical. In this paper we study such accidents taking the Superconducting Supercollider complex as an example. Particle tracking, beam loss and energy deposition calculations were done using the realistic machine simulation with the Monte-Carlo codes MARS 12 and STRUCT. Protective measures for minimizing the damaging effects of prefire and misfire of injection and extraction kicker magnets are proposed here

  8. Functional and Linearity test system for the LHC Beam Loss Monitoring data acquisition card

    CERN Document Server

    Emery, Jonathan; Effinger, E; Leitner, R; Zamantzas, C

    2007-01-01

    In the frame of the design and development of the beam loss monitoring (BLM) system for the Large Hadron Collider (LHC) a flexible test system has been developed to qualify and verify during design and production the BLM LHC data acquisition card. It permits to test completely the functionalities of the board as well as realizing analog input signal generation to the acquisition card. The system utilize two optical receivers, a Field Programmable Gate Array (FPGA), eights flexible current sources and a Universal Serial Bus (USB) to link it to a PC where a software written in LabWindows/CVI© (National Instruments) runs. It includes an important part of the measurement processing developed for the BLM in the future LHC accelerator. It is called Beam Loss Electronic Current to Frequency Tester (BLECFT).

  9. Precessed electron beam electron energy loss spectroscopy of graphene: Beyond channelling effects

    International Nuclear Information System (INIS)

    Yedra, Ll.; Estradé, S.; Torruella, P.; Eljarrat, A.; Peiró, F.; Darbal, A. D.; Weiss, J. K.

    2014-01-01

    The effects of beam precession on the Electron Energy Loss Spectroscopy (EELS) signal of the carbon K edge in a 2 monolayer graphene sheet are studied. In a previous work, we demonstrated the use of precession to compensate for the channeling-induced reduction of EELS signal when in zone axis. In the case of graphene, no enhancement of EELS signal is found in the usual experimental conditions, as graphene is not thick enough to present channeling effects. Interestingly, though it is found that precession makes it possible to increase the collection angle, and, thus, the overall signal, without a loss of signal-to-background ratio

  10. Instrumentation for EXELFS measurements using convergent beam diffraction coupling to the electron energy loss spectrometer

    International Nuclear Information System (INIS)

    Yuan Zou Wei; Csillag, S.; Tafreshi, M.A.

    1993-08-01

    Convergent beam diffraction coupling between a JEOL-100C scanning transmission microscope and an electron energy loss spectrometer is realised for the purpose of Extended Energy Loss Fine Structure (EXELFS) measurements. The working principle, the instrumentation for this coupling mode and some specific details, such as condenser system, shadow image, focusing conditions and measurement of convergent angles are described and discussed. The combination of a quadrupole and cylindrical lens for magnifying the image and increasing the dispersion of spectrum, together with a new type of compensation circuit for stray magnetic fields and the arrangement of the parallel recording system are also reported

  11. Simulation of the ATLAS SCT Barrel Module Response to LHC Beam Loss Scenarios

    CERN Document Server

    Rose, P; The ATLAS collaboration; Fadeyev, V; Spencer, E; Wilder, M; Domingo, M

    2013-01-01

    In the event of beam loss at the LHC, ATLAS Inner Detector components nearest the beamline may be subjected to unusually large amounts of radiation. Understanding their behavior in such an event is important in determining whether they would still function properly. We built a SPICE model of the silicon strip module electrical system to determine the behavior of its elements during a realistic beam loss scenario. We found that the power supply and bias filter characteristics strongly affect the module response in such scenarios. In particular, the following self-limiting phenomena were observed: there is a finite amount of charge initially available on the bias filter capacitors for collection by the strips; the power supply current limit reduces the rate at which the bias filter capacitors' charge can be replenished; the reduced bias voltage leads to a smaller depletion depth which results in less collected charge. These effects provide a larger measure of safety during beam loss events than we have previous...

  12. Quench Tests of LHC Magnets with Beam: Studies on Beam Loss development and determination of Quench levels

    CERN Document Server

    Priebe, A; Sapinski, M

    The application of superconducting materials in the field of high energy accelerator physics not only opens the doors to the generation of the magnetic fields unattainable to normal conductors but also demands facing new challenges. A transition fromthe superconducting state, which is characterized by a resistance-free flow of the electric current, to the normal conducting state is called quenching. This process might be extremely dangerous and even lead to destruction of amagnet superconducting coil if no protecting actions are taken. Therefore, the knowledge of a magnet quench level, i.e. amount of energy which causes the transition to the resistive state, is crucial for the safety and operational efficiency of the accelerator. Regarding that, specific thresholds are incorporated to dedicated quench prevention systems in order to suppress the origin of detected energy perturbation, for example beam losses, or mitigate the consequences of the quenching process by dissipating the energy stored in the magnetic...

  13. Prestress Loss and Bending Capacity of Pre-cracked 40 Year-Old PC Beams Exposed to Marine Environment

    Directory of Open Access Journals (Sweden)

    Dasar Amry

    2016-01-01

    Full Text Available Six prestressed concrete beams (PC beam were used for evaluation, consist of four post-tension beams (PC-O and two pre-tension beams (PC-R. In order to investigate the effect of crack on prestress loss and bending capacity after long-term exposed, prestressed concrete beams were pre-crack and then exposed to marine environment. Experimental work was carried out to evaluate PC beams performance after long-term exposed. In addition, visual observations and load bearing capacity test was carried out. Furthermore, evaluation of prestress loss conducted using three-point loading bending test and the remaining tendon forces in the beam were determined using Crack Re-opening Method. The experimental results revealed that prestress loss was increased due to corrosion of strand/wire which affected by the pre-crack on the prestressed beams. Approximately a prestress loss around 26% and 30% was recorded for post-tension and pre-tension beams respectively.

  14. Development of the Readout Electronics for the Beam Loss Monitors of the LHC

    CERN Document Server

    Friesenbichler, W

    2002-01-01

    The Large Hadron Collider (LHC) of the European Laboratory for Particle Physics will be the largest particle accelerator in the world. It requires a large number of installations for its operation. One of these installations are the beam loss monitors which measure the particle losses. If these losses exceed a certain level, the beam must be extracted, otherwise the superconducting magnets could be damaged. For this reason, ionization chambers are installed outside the cryostat to transform the losses into an electric current. A wide dynamic range front end was developed to measure this current. The circuit consists of a current-to-frequency converter that works on the principle of balanced charge. Its output frequency is evaluated by counters and the data is serially transmitted from the tunnel to the surface, where the final data processing is performed. The data transmission suffers from the long cabling distance of up to 2 km. Using Manchester Code and line equalizers enables a data rate of 2 Mbit/s over ...

  15. Reliability of the beam loss monitors system for the large hadron collider at CERN

    International Nuclear Information System (INIS)

    Guaglio, G.

    2005-12-01

    The energy stored in the Large Hadron Collider is unprecedented. The impact of the beam particles can cause severe damage on the superconductive magnets, resulting in significant downtime for repairing. The Beam Loss Monitors System (BLMS) detects the secondary particles shower of the lost beam particles and initiates the extraction of the beam before any serious damage to the equipment can occur. This thesis defines the BLMS specifications in term of reliability. The main goal is the design of a system minimizing both the probability to not detect a dangerous loss and the number of false alarms generated. The reliability theory and techniques utilized are described. The prediction of the hazard rates, the testing procedures, the Failure Modes Effects and Criticalities Analysis and the Fault Tree Analysis have been used to provide an estimation of the probability to damage a magnet, of the number of false alarms and of the number of generated warnings. The weakest components in the BLMS have been pointed out. The reliability figures of the BLMS have been calculated using a commercial software package (Isograph.). The effect of the variation of the parameters on the obtained results has been evaluated with a sensitivity analysis. The reliability model has been extended by the results of radiation tests. Design improvements, like redundant optical transmission, have been implemented in an iterative process. The proposed system is compliant with the reliability requirements. The model uncertainties are given by the limited knowledge of the thresholds levels of the superconductive magnets and of the locations of the losses along the ring. The implemented model allows modifications of the system, following the measuring of the hazard rates during the LHC life. It can also provide reference numbers to other accelerators which will implement similar technologies. (author)

  16. Generation of Homogeneous and Patterned Electron Beams using a Microlens Array Laser-Shaping Technique

    Energy Technology Data Exchange (ETDEWEB)

    Halavanau, Aliaksei [NICADD, DeKalb; Edstrom, Dean [Fermilab; Gai, Wei [Argonne, HEP; Ha, Gwanghui [Argonne, HEP; Piot, Philippe [NICADD, DeKalb; Power, John [Argonne, HEP; Qiang, Gao [Unlisted, CN; Ruan, Jinhao [Fermilab; Santucci, James [Fermilab; Wisniewski, Eric [Argonne, HEP

    2016-06-01

    In photocathodes the achievable electron-beam parameters are controlled by the laser used to trigger the photoemission process. Non-ideal laser distribution hampers the final beam quality. Laser inhomogeneities, for instance, can be "amplified" by space-charge force and result in fragmented electron beams. To overcome this limitation laser shaping methods are routinely employed. In the present paper we demonstrate the use of simple microlens arrays to dramatically improve the transverse uniformity. We also show that this arrangement can be used to produce transversely-patterned electron beams. Our experiments are carried out at the Argonne Wakefield Accelerator facility.

  17. Germanium growth on electron beam lithography patterned Si3N4/Si(001) substrate using molecular beam epitaxy

    Science.gov (United States)

    Sarkar, Subhendu Sinha; Katiyar, Ajit K.; Sarkar, Arijit; Dhar, Achintya; Rudra, Arun; Khatri, Ravinder K.; Ray, Samit Kumar

    2018-04-01

    It is important to investigate the growth dynamics of Ge adatoms under different surface stress regimes of the patterned dielectric to control the selective growth of self-assembled Ge nanostructures on silicon. In the present work, we have studied the growth of Ge by molecular beam epitaxy on nanometer scale patterned Si3N4/Si(001) substrates generated using electron beam lithography. The pitch of the patterns has been varied to investigate its effect on the growth of Ge in comparison to un-patterned Si3N4. For the patterned Si3N4 film, Ge did not desorbed completely from the Si3N4 film and hence no site selective growth pattern is observed. Instead, depending upon the pitch, Ge growth has occurred in different growth modes around the openings in the Si3N4. For the un-patterned substrate, the morphology exhibits the occurrence of uniform 3D clustering of Ge adatoms on Si3N4 film. This variation in the growth modes of Ge is attributed to the variation of residual stress in the Si3N4 film for different pitch of holes, which has been confirmed theoretically through Comsol Multiphysics simulation. The variation in stress for different pitches resulted in modulation of surface energy of the Si3N4 film leading to the different growth modes of Ge.

  18. A low cost high resolution pattern generator for electron-beam lithography

    International Nuclear Information System (INIS)

    Pennelli, G.; D'Angelo, F.; Piotto, M.; Barillaro, G.; Pellegrini, B.

    2003-01-01

    A simple, very low cost pattern generator for electron-beam lithography is presented. When it is applied to a scanning electron microscope, the system allows a high precision positioning of the beam for lithography of very small structures. Patterns are generated by a suitable software implemented on a personal computer, by using very simple functions, allowing an easy development of new writing strategies for a great adaptability to different user necessities. Hardware solutions, as optocouplers and battery supply, have been implemented for reduction of noise and disturbs on the voltages controlling the positioning of the beam

  19. Lithographic analysis of multipass gray writing strategy for electron-beam pattern generation

    Science.gov (United States)

    Chabala, Jan M.; Abboud, Frank E.; Dean, Robert L.; Weaver, Suzanne; Cole, Damon M.; Sauer, Charles A.; Raymond, Frederick, III; Hofmann, Ulrich

    1999-06-01

    Gray-level printing is an efficient strategy to create small-address patterns on photomasks. This work provides a technical description of the multipass gray (MPG) raster- scan writing technique as implemented on the MEBES 4500S and MEBES 5000 electron-beam pattern generation tools. The differences between single-pass printing (SPP) and MPG are reviewed. The factors that allow increase in throughput and dose with MPG are explained. Aerial image simulations of edge placement and corner rounding verify the MPG model. Multipass writing with offset scan voting, which reduces random and systematic errors, is explained. Because MPG is a gray-level printing technique, the dose distribution across feature edges is necessarily broader than that derived from SPP writing. Simulations and experimental results indicate that, using ZEP 7000 resist and dry etch, edges can be placed without loss of accuracy, despite the width of this 'gray' profile. The spot size necessary to obtain optimal critical dimension quality is also determined by simulation and empirically. The lithographic quality of MPG writing/processing is confirmed by composite metrology test that sample the whole quality area of the mask. We conclude that MPG is a viable technique for writing advanced masks.

  20. Synthesis of Pt nanoparticles and their burrowing into Si due to synergistic effects of ion beam energy losses

    Directory of Open Access Journals (Sweden)

    Pravin Kumar

    2014-10-01

    Full Text Available We report the synthesis of Pt nanoparticles and their burrowing into silicon upon irradiation of a Pt–Si thin film with medium-energy neon ions at constant fluence (1.0 × 1017 ions/cm2. Several values of medium-energy neon ions were chosen in order to vary the ratio of the electronic energy loss to the nuclear energy loss (Se/Sn from 1 to 10. The irradiated films were characterized using Rutherford backscattering spectroscopy (RBS, atomic force microscopy (AFM, scanning electron microscopy (SEM, X-ray diffraction (XRD and high resolution transmission electron microscopy (HRTEM. A TEM image of a cross section of the film irradiated with Se/Sn = 1 shows ≈5 nm Pt NPs were buried up to ≈240 nm into the silicon. No silicide phase was detected in the XRD pattern of the film irradiated at the highest value of Se/Sn. The synergistic effect of the energy losses of the ion beam (molten zones are produced by Se, and sputtering and local defects are produced by Sn leading to the synthesis and burrowing of Pt NPs is evidenced. The Pt NP synthesis mechanism and their burrowing into the silicon is discussed in detail.

  1. Pattern data handling system for an electron beam exposure system

    International Nuclear Information System (INIS)

    Berrian, D.W.; Ward, B.W.

    1985-01-01

    A beam is blanked over a rectangular area by storing beam blanking data in a bit map memory having data words of n bits. An address counter is loaded with the x-coordinate of the location of the rectangle and inhibited (by word counter) from counting after advancing through a number of addresses corresponding to the length of the rectangle. Mask bits whose position determines the y-coordinate of the location of the rectangle and whose number determines the width of the rectangle are loaded into a mask latch having n bit locations each with an output coupled to write enable inputs of the memory corresponding to the n bits of the data words in the memory. As the address counter advances through the number of addresses corresponding to the length of the rectangle, data describing the rectangle is stored in the memory without altering masked parts of previously stored blanking data. (author)

  2. Focused ion beam patterned Hall nano-sensors

    International Nuclear Information System (INIS)

    Candini, A.; Gazzadi, G.C.; Di Bona, A.; Affronte, M.; Ercolani, D.; Biasiol, G.; Sorba, L.

    2007-01-01

    By means of focused ion beam milling, we fabricate Hall magnetometers with active areas as small as 100x100nm 2 . The constituent material can either be metallic (Au), semimetallic (Bi) or doped bulk semiconducting (Si doped GaAs). We experimentally show that Au nano-probes can work from room temperature down to liquid helium with magnetic flux sensitivity -1 Φ 0

  3. Evaluation of support loss in micro-beam resonators: A revisit

    Science.gov (United States)

    Chen, S. Y.; Liu, J. Z.; Guo, F. L.

    2017-12-01

    This paper presents an analytical study on evaluation of support loss in micromechanical resonators undergoing in-plane flexural vibrations. Two-dimensional elastic wave theory is used to determine the energy transmission from the vibrating resonator to the support. Fourier transform and Green's function technique are adopted to solve the problem of wave motions on the surface of the support excited by the forces transmitted by the resonator onto the support. Analytical expressions of support loss in terms of quality factor, taking into account distributed normal stress and shear stress in the attachment region, and coupling between the normal stress and shear stress as well as material disparity between the support and the resonator, have been derived. Effects of geometry of micro-beam resonators, and material dissimilarity between support and resonator on support loss are examined. Numerical results show that 'harder resonator' and 'softer support' combination leads to larger support loss. In addition, the Perfectly Matched Layer (PML) numerical simulation technique is employed for validation of the proposed analytical model. Comparing with results of quality factor obtained by PML technique, we find that the present model agrees well with the results of PML technique and the pure-shear model overestimates support loss noticeably, especially for resonators with small aspect ratio and large material dissimilarity between the support and resonator.

  4. Comparison of LHC Beam Loss Maps Using the Transverse Damper Blow Up and Tune Resonance Crossing Methods

    CERN Document Server

    Moens, V; Redaelli, S; Salvachua, B; Valentino, G

    2013-01-01

    The LHC collimator settings are qualified regularly via beam loss maps. In this procedure, the beam is artificially excited to create abnormal loss rates. The transverse damper blow up (ADT) and tune resonance crossing methods (QT) are used to increase the betatron amplitude of particles and verify the efficiency of the collimation cleaning hierarchy in IR7. This paper presents a quantitative comparison of the methods, for the qualification of the collimator settings at different operating points in the LHC machine cycle. The analysis is done using Beam Loss Monitor (BLM) with integration times of 1.3 s and 80 ms, the latter being available as from the 2012 run onwards. We present here the use of the faster BLM data (80 ms) to study the time evolution of the losses in IR3 and IR7 during offmomentum loss maps.

  5. Beam loss problems and acceleration of proton currents of 300 mA in the Fermilab 200-MeV linear accelerator

    International Nuclear Information System (INIS)

    Young, D.E.

    1977-01-01

    Two types of proton beam-loss problems that must be managed are discussed. A fast loss of the beam happens usually when a sudden malfunction of a component or system occurs. Slow loss of beam occurs when components deviate slightly from their ideal values, when misalignments occur, when high-intensity effects cause a growth in beam size, when extraneous resonance effects occur, or in any of a large number of other ways. The loss of beam is gradual and if the loss of beam is allowed to continue large levels of residual radioactivity can build up. Beam losses in the 500-GeV Main Ring Synchrotron and in the Fermilab 200-MeV Linear Accelerator are discussed, and the experience acquired for the latter is generalized for other linear accelerators. Production of 300 mA proton beams in the Fermilab Linac is described

  6. Enhanced Etching, Surface Damage Recovery, and Submicron Patterning of Hybrid Perovskites using a Chemically Gas-Assisted Focused-Ion Beam for Subwavelength Grating Photonic Applications

    KAUST Repository

    Alias, Mohd Sharizal

    2015-12-22

    The high optical gain and absorption of organic–inorganic hybrid perovskites have attracted attention for photonic device applications. However, owing to the sensitivity of organic moieties to solvents and temperature, device processing is challenging, particularly for patterning. Here, we report the direct patterning of perovskites using chemically gas-assisted focused-ion beam (GAFIB) etching with XeF2 and I2 precursors. We demonstrate etching enhancement in addition to controllability and marginal surface damage compared to focused-ion beam (FIB) etching without precursors. Utilizing the GAFIB etching, we fabricated a uniform and periodic submicron perovskite subwavelength grating (SWG) absorber with broadband absorption and nanoscale precision. Our results demonstrate the use of FIB as a submicron patterning tool and a means of providing surface treatment (after FIB patterning to minimize optical loss) for perovskite photonic nanostructures. The SWG absorber can be patterned on perovskite solar cells to enhance the device efficiency through increasing light trapping and absorption.

  7. Compact LCOS–SLM Based Polarization Pattern Beam Generator

    OpenAIRE

    Zheng, Xuejie; Lizana Tutusaus, Ángel; Peinado, Alba; Ramírez, Claudio; Martínez, Jose L.; Márquez, Andrés; Moreno Soriano, Ignacio; Campos Coloma, Juan

    2015-01-01

    In this paper, a compact optical system for generating arbitrary spatial light polarization patterns is demonstrated. The system uses a single high-resolution liquid crystal (LC) on silicon (LCOS) spatial light modulator. A specialized optical mount is designed and fabricated using a 3D printer, in order to build a compact dual optical architecture, where two different phase patterns are encoded on two adjacent halves of the LCOS screen, with a polarization transformation in between. The fina...

  8. Argon ion beam induced surface pattern formation on Si

    Energy Technology Data Exchange (ETDEWEB)

    Hofsäss, H.; Bobes, O.; Zhang, K. [2nd Institute of Physics, Faculty of Physics, University Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen (Germany)

    2016-01-21

    The development of self-organized surface patterns on Si due to noble gas ion irradiation has been studied extensively in the past. In particular, Ar ions are commonly used and the pattern formation was analyzed as function of ion incidence angle, ion fluence, and ion energies between 250 eV and 140 keV. Very few results exist for the energy regime between 1.5 keV and 10 keV and it appears that pattern formation is completely absent for these ion energies. In this work, we present experimental data on pattern formation for Ar ion irradiation between 1 keV and 10 keV and ion incidence angles between 50° and 75°. We confirm the absence of patterns at least for ion fluences up to 10{sup 18} ions/cm{sup 2}. Using the crater function formalism and Monte Carlo simulations, we calculate curvature coefficients of linear continuum models of pattern formation, taking into account contribution due to ion erosion and recoil redistribution. The calculations consider the recently introduced curvature dependence of the erosion crater function as well as the dynamic behavior of the thickness of the ion irradiated layer. Only when taking into account these additional contributions to the linear theory, our simulations clearly show that that pattern formation is strongly suppressed between about 1.5 keV and 10 keV, most pronounced at 3 keV. Furthermore, our simulations are now able to predict whether or not parallel oriented ripple patterns are formed, and in case of ripple formation the corresponding critical angles for the whole experimentally studied energies range between 250 eV and 140 keV.

  9. A Compactrio-Based Beam Loss Monitor For The SNS RF Test Cave

    International Nuclear Information System (INIS)

    Blokland, Willem; Armstrong, Gary A.

    2009-01-01

    An RF Test Cave has been built at the Spallation Neutron Source (SNS) to be able to test RF cavities without interfering the SNS accelerator operations. In addition to using thick concrete wall to minimize radiation exposure, a Beam Loss Monitor (BLM) must abort the operation within 100 usec when the integrated radiation within the cave exceeds a threshold. We choose the CompactRIO platform to implement the BLM based on its performance, cost-effectiveness, and rapid development. Each in/output module is connected through an FPGA to provide point-by-point processing. Every 10 usec the data is acquired analyzed and compared to the threshold. Data from the FPGA is transferred using DMA to the real-time controller, which communicates to a gateway PC to talk to the SNS control system. The system includes diagnostics to test the hardware and integrates the losses in real-time. In this paper we describe our design, implementation, and results

  10. Prompt Loss of Energetic Ions during Early Neutral Beam Injection in the National Spherical Torus Experiment

    Energy Technology Data Exchange (ETDEWEB)

    S.S. Medley; D.S. Darrow; D. Liu; A.L. Roquemore

    2005-03-25

    Early neutral-beam injection is used in the National Spherical Torus Experiment (NSTX) to heat the electrons and slow current penetration which keeps q(0) elevated to avoid deleterious MHD activity and at the same time reduces Ohmic flux consumption, all of which aids long-pulse operation. However, the low plasma current (I{sub p} {approx} 0.5 MA) and electron density (n{sub e} {approx} 1 x 10{sup 13} cm{sup -3}) attending early injection lead to elevated orbit and shine through losses. The inherent orbit losses are aggravated by large excursions in the outer gap width during current ramp-up. An investigation of this behavior using various energetic particle diagnostics on NSTX and TRANSP code analysis is presented.

  11. Experimental investigation of the ripple induced losses of perpendicularly injected beam ions in the low aspect ratio helical system CHS

    International Nuclear Information System (INIS)

    Isobe, M.; Sasao, M.; Okamura, S.; Murakami, S.; Minami, T.; Kado, S.; Ida, K.; Osakabe, M.; Yoshimura, Y.; Tanaka, K.; Takahashi, C.; Nishimura, S.; Matsuoka, K.; Kondo, T.; Shimizu, A.; Yavorskij, V.A.

    2001-01-01

    Confinement of perpendicularly injected beam ions has been investigated experimentally both in the standard configuration and in the drift optimized configuration of the CHS heliotron/torsatron by means of the neutron technique. The experimental results indicate that the confinement of trapped beam ions is poor in both configurations. The observed loss rate of trapped beam ions was very high and this high rate is not explained by losses due to charge exchange or collisional scattering from the timescale perspective. Full gyro-motion following orbit calculations showed that in the peripheral region of CHS plasmas, trapped beam ions are promptly lost because they immediately intersect the vacuum chamber wall due to their large Larmor radii. It also suggested that in the core domain the collisionless transition behaviour is the key to understanding the rapid loss of beam ions. It was shown that the magnetic moment of perpendicularly injected beam ions is not well conserved in CHS. The rapid losses of perpendicularly injected beam ions are probably due to non-adiabatic effects resulting in the transition behaviour of energetic ions. (author)

  12. Experimental investigation of the ripple induced losses of perpendicularly injected beam ions in the low aspect ratio helical system CHS

    Science.gov (United States)

    Isobe, M.; Sasao, M.; Okamura, S.; Kondo, T.; Murakami, S.; Minami, T.; Kado, S.; Ida, K.; Shimizu, A.; Osakabe, M.; Yoshimura, Y.; Tanaka, K.; Takahashi, C.; Nishimura, S.; Matsuoka, K.; CHS Group; Yavorskij, V. A.

    2001-09-01

    Confinement of perpendicularly injected beam ions has been investigated experimentally both in the standard configuration and in the drift optimized configuration of the CHS heliotron/torsatron by means of the neutron technique. The experimental results indicate that the confinement of trapped beam ions is poor in both configurations. The observed loss rate of trapped beam ions was very high and this high rate is not explained by losses due to charge exchange or collisional scattering from the timescale perspective. Full gyro-motion following orbit calculations showed that in the peripheral region of CHS plasmas, trapped beam ions are promptly lost because they immediately intersect the vacuum chamber wall due to their large Larmor radii. It also suggested that in the core domain the collisionless transition behaviour is the key to understanding the rapid loss of beam ions. It was shown that the magnetic moment of perpendicularly injected beam ions is not well conserved in CHS. The rapid losses of perpendicularly injected beam ions are probably due to non-adiabatic effects resulting in the transition behaviour of energetic ions.

  13. THz Beam Shaper Realizing Fan-Out Patterns

    Science.gov (United States)

    Liebert, K.; Rachon, M.; Siemion, A.; Suszek, J.; But, D.; Knap, W.; Sypek, M.

    2017-08-01

    Fan-out elements create an array of beams radiating at particular angles along the propagation axis. Therefore, they are able to form a matrix of equidistant spots in the far-field diffraction region. In this work, we report on the first fan-out structures designed for the THz range of radiation. Two types of light-dividing fan-out structures are demonstrated: (i) the 3×1 matrix fan-out structure based on the optimized binary phase grating and (ii) the 3×3 fan-out structure designed on the basis of the well-known Dammann grating. The structures were generated numerically and manufactured using the 3D printing technique with polyamide PA12. To obtain equal powers and symmetry of diffracted beams, the computer-aided optimization algorithm was used. Diffractive optical elements designed for 140 and 282 GHz were evaluated experimentally at both these frequencies using illumination with the wavefront coming from the point-like source. Described fan-out elements formed uniform intensity and equidistant energy distribution in agreement with the numerical simulations.

  14. Compositional sorting dynamics in coexisting lipid bilayer phases with variations in underlying e-beam formed curvature pattern.

    Science.gov (United States)

    Ogunyankin, Maria O; Longo, Marjorie L

    2013-07-07

    Nanometer-scale curvature patterns of an underlying substrate are imposed on lipid multibilayers with each pattern imparting distinctly different sorting dynamics to a metastable pixelation pattern of coexisting liquid ordered (Lo)-liquid disordered (Ld) lipid phases. Therefore, this work provides pathways toward mechanical energy-based separations for analysis of biomembrane-associate species. The central design concept of the patterned sections of the silica substrate is a square lattice pattern of 100 nm projected radius poly(methyl methacrylate) (PMMA) hemispherical features formed by electron beam lithography which pixelates the coexisting phases in order to balance membrane bending and line energy. In one variation, we surround this pattern with three PMMA walls/fences 100 nm in height which substantially slows the loss of the high line energy pixelated Lo phase by altering the balance of two competing mechanism (Ostwald ripening vs. vesiculation). In another walled variation, we form a gradient of the spacing of the 100 nm features which forces partitioning of the Lo phase toward the end of the gradient with the most open (400 nm spacing) lattice pattern where a single vesicle could grow from the Lo phase. We show that two other variations distinctly impact the dynamics, demonstrating locally slowed loss of the high line energy pixelated Lo phase and spontaneous switching of the pixel location on the unit cell, respectively. Moreover, we show that the pixelation patterns can be regenerated and sharpened by a heating and cooling cycle. We argue that localized variations in the underlying curvature pattern have rather complex consequences because of the coupling and/or competition of dynamic processes to optimize mechanical energy such as lipid diffusion, vesiculation and growth, and phase/compositional partitioning.

  15. Neon ion beam induced pattern formation on amorphous carbon surfaces

    Directory of Open Access Journals (Sweden)

    Omar Bobes

    2018-02-01

    Full Text Available We investigate the ripple pattern formation on amorphous carbon surfaces at room temperature during low energy Ne ion irradiation as a function of the ion incidence angle. Monte Carlo simulations of the curvature coefficients applied to the Bradley-Harper and Cater-Vishnyakov models, including the recent extensions by Harrison-Bradley and Hofsäss predict that pattern formation on amorphous carbon thin films should be possible for low energy Ne ions from 250 eV up to 1500 eV. Moreover, simulations are able to explain the absence of pattern formation in certain cases. Our experimental results are compared with prediction using current linear theoretical models and applying the crater function formalism, as well as Monte Carlo simulations to calculate curvature coefficients using the SDTrimSP program. Calculations indicate that no patterns should be generated up to 45° incidence angle if the dynamic behavior of the thickness of the ion irradiated layer introduced by Hofsäss is taken into account, while pattern formation most pronounced from 50° for ion energy between 250 eV and 1500 eV, which are in good agreement with our experimental data.

  16. Demonstration of electronic pattern switching and 10x pattern demagnification in a maskless micro-ion beam reduction lithography system

    International Nuclear Information System (INIS)

    Ngo, V.V.; Akker, B.; Leung, K.N.; Noh, I.; Scott, K.L.; Wilde, S.

    2002-01-01

    A proof-of-principle ion projection lithography (IPL) system called Maskless Micro-ion beam Reduction Lithography (MMRL) has been developed and tested at the Lawrence Berkeley National Laboratory (LBNL) for future integrated circuits (ICs) manufacturing and thin film media patterning [1]. This MMRL system is aimed at completely eliminating the first stage of the conventional IPL system [2] that contains the complicated beam optics design in front of the stencil mask and the mask itself. It consists of a multicusp RF plasma generator, a multi-beamlet pattern generator, and an all-electrostatic ion optical column. Results from ion beam exposures on PMMA and Shipley UVII-HS resists using 75 keV H+ are presented in this paper. Proof-of-principle electronic pattern switching together with 10x reduction ion optics (using a pattern generator made of nine 50-(micro)m switchable apertures) has been performed and is reported in this paper. In addition, the fabrication of a micro-fabricated pattern generator [3] on an SOI membrane is also presented

  17. Patterns and drivers of scattered tree loss in agricultural landscapes

    DEFF Research Database (Denmark)

    Plieninger, Tobias; Levers, Christian; Mantel, Martin

    2015-01-01

    Scattered trees support high levels of farmland biodiversity and ecosystem services in agricultural landscapes, but they are threatened by agricultural intensification, urbanization, and land abandonment. This study aimed to map and quantify the decline of orchard meadows (scattered fruit trees...... of high nature conservation value) for a region in Southwestern Germany for the 1968 2009 period and to identify the driving forces of this decline. We derived orchard meadow loss from 1968 and 2009 aerial images and used a boosted regression trees modelling framework to assess the relative importance...... of 18 environmental, demographic, and socio-economic variables to test five alternative hypothesis explaining orchard meadow loss. We found that orchard meadow loss occurred in flatter areas, in areas where smaller plot sizes and fragmented orchard meadows prevailed, and in areas near settlements...

  18. Biodiversity loss decreases parasite diversity: theory and patterns.

    Science.gov (United States)

    Lafferty, Kevin D

    2012-10-19

    Past models have suggested host-parasite coextinction could lead to linear, or concave down relationships between free-living species richness and parasite richness. I explored several models for the relationship between parasite richness and biodiversity loss. Life cycle complexity, low generality of parasites and sensitivity of hosts reduced the robustness of parasite species to the loss of free-living species diversity. Food-web complexity and the ordering of extinctions altered these relationships in unpredictable ways. Each disassembly of a food web resulted in a unique relationship between parasite richness and the richness of free-living species, because the extinction trajectory of parasites was sensitive to the order of extinctions of free-living species. However, the average of many disassemblies tended to approximate an analytical model. Parasites of specialist hosts and hosts higher on food chains were more likely to go extinct in food-web models. Furthermore, correlated extinctions between hosts and parasites (e.g. if parasites share a host with a specialist predator) led to steeper declines in parasite richness with biodiversity loss. In empirical food webs with random removals of free-living species, the relationship between free-living species richness and parasite richness was, on average, quasi-linear, suggesting biodiversity loss reduces parasite diversity more than previously thought.

  19. Patterns of non-embolic transient monocular visual field loss

    NARCIS (Netherlands)

    Petzold, A.; Islam, N.; Plant, G.T.

    2013-01-01

    The aim of this study was to systematically describe the semiology of non-embolic transient monocular visual field loss (neTMVL). We conducted a retrospective case note analysis of patients from Moorfields Eye Hospital (1995-2007). The variables analysed were age, age of onset, gender, past medical

  20. Codesign of Beam Pattern and Sparse Frequency Waveforms for MIMO Radar

    Directory of Open Access Journals (Sweden)

    Chaoyun Mai

    2015-01-01

    Full Text Available Multiple-input multiple-output (MIMO radar takes the advantages of high degrees of freedom for beam pattern design and waveform optimization, because each antenna in centralized MIMO radar system can transmit different signal waveforms. When continuous band is divided into several pieces, sparse frequency radar waveforms play an important role due to the special pattern of the sparse spectrum. In this paper, we start from the covariance matrix of the transmitted waveform and extend the concept of sparse frequency design to the study of MIMO radar beam pattern. With this idea in mind, we first solve the problem of semidefinite constraint by optimization tools and get the desired covariance matrix of the ideal beam pattern. Then, we use the acquired covariance matrix and generalize the objective function by adding the constraint of both constant modulus of the signals and corresponding spectrum. Finally, we solve the objective function by the cyclic algorithm and obtain the sparse frequency MIMO radar waveforms with desired beam pattern. The simulation results verify the effectiveness of this method.

  1. Wetland Loss Patterns and Inundation-Productivity Relationships Prognosticate Widespread Salt Marsh Loss for Southern New England

    Science.gov (United States)

    Tidal salt marsh is a key defense against, yet is especially vulnerable to, the effects of accelerated sea level rise. To determine whether salt marshes in southern New England will be stable given increasing inundation over the coming decades, we examined current loss patterns, ...

  2. Preliminary design of the beam loss monitor system for the Advanced Photon Source

    International Nuclear Information System (INIS)

    Patterson, D.R.

    1992-01-01

    The preliminary design of the beam loss monitor for the ANL Advanced Photon Source is based on the use of an air dielectric coaxial cable as a long ionization chamber. Each coaxial cable section uses a high sensitivity DC current-to-voltage converter with both linear and integrating ranges. Pulse timing circuits determine the positions of individual losses by measuring the time at which the resulting voltage pulses arrive at the beginning of the coaxial ionization chamber. A possible timing ambiguity can be removed by correlating the particle bunch timing with the resulting voltage pulse timing. Measurements have shown that pulse rise times less than 15 nanoseconds can be obtained, so that determining loss locations to better than 7 feet may be possible. Best performance may be obtained when 500 VDC is applied to a 50-ohm, 7/8-inch air dielectric coaxial cable filled with approximately 8 psig of a 95% argon, 5% carbon dioxide gas mixture. Cable lengths will be between 100 and 300 feet long, depending on the part of the accelerator being monitored

  3. 26 CFR 1.846-2 - Election by taxpayer to use its own historical loss payment pattern.

    Science.gov (United States)

    2010-04-01

    ... loss payment pattern. 1.846-2 Section 1.846-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF... Election by taxpayer to use its own historical loss payment pattern. (a) In general. If a taxpayer has one... historical loss payment pattern instead of the industry-wide pattern determined by the Secretary. A taxpayer...

  4. Receiving beam patterns in the horizontal plane of a harbor porpoise (Phocoena phocoena)

    Science.gov (United States)

    Kastelein, Ronald A.; Janssen, Mirjam; Verboom, Willem C.; de Haan, Dick

    2005-08-01

    Receiving beam patterns of a harbor porpoise were measured in the horizontal plane, using narrow-band frequency modulated signals with center frequencies of 16, 64, and 100 kHz. Total signal duration was 1000 ms, including a 200 ms rise time and 300 ms fall time. The harbor porpoise was trained to participate in a psychophysical test and stationed itself horizontally in a specific direction in the center of a 16-m-diameter circle consisting of 16 equally-spaced underwater transducers. The animal's head and the transducers were in the same horizontal plane, 1.5 m below the water surface. The go/no-go response paradigm was used; the animal left the listening station when it heard a sound signal. The method of constants was applied. For each transducer the 50% detection threshold amplitude was determined in 16 trials per amplitude, for each of the three frequencies. The beam patterns were not symmetrical with respect to the midline of the animal's body, but had a deflection of 3-7° to the right. The receiving beam pattern narrowed with increasing frequency. Assuming that the pattern is rotation-symmetrical according to an average of the horizontal beam pattern halves, the receiving directivity indices are 4.3 at 16 kHz, 6.0 at 64 kHz, and 11.7 dB at 100 kHz. The receiving directivity indices of the porpoise were lower than those measured for bottlenose dolphins. This means that harbor porpoises have wider receiving beam patterns than bottlenose dolphins for the same frequencies. Directivity of hearing improves the signal-to-noise ratio and thus is a tool for a better detection of certain signals in a given ambient noise condition.

  5. High-damage-threshold static laser beam shaping using optically patterned liquid-crystal devices.

    Science.gov (United States)

    Dorrer, C; Wei, S K-H; Leung, P; Vargas, M; Wegman, K; Boulé, J; Zhao, Z; Marshall, K L; Chen, S H

    2011-10-15

    Beam shaping of coherent laser beams is demonstrated using liquid crystal (LC) cells with optically patterned pixels. The twist angle of a nematic LC is locally set to either 0 or 90° by an alignment layer prepared via exposure to polarized UV light. The two distinct pixel types induce either no polarization rotation or a 90° polarization rotation, respectively, on a linearly polarized optical field. An LC device placed between polarizers functions as a binary transmission beam shaper with a highly improved damage threshold compared to metal beam shapers. Using a coumarin-based photoalignment layer, various devices have been fabricated and tested, with a measured single-shot nanosecond damage threshold higher than 30 J/cm2.

  6. Retrograde amnesia produced by electron beam exposure: causal parameters and duration of memory loss

    International Nuclear Information System (INIS)

    Wheeler, T.G.; Hardy, K.A.

    1985-01-01

    The production of retrograde amnesia (RA) upon electron beam exposure has been investigated. RA production was evaluated using a single-trial avoidance task across a 10 4 dose range for 10-, 1-, and 0.1-μsec pulsed exposures. The dose-response curve obtained at each pulse duration showed significant RA production. The most effective dose range was 0.1-10 rad at a dose rate of 10 6 rad/sec. By employing a 10 rad (10 6 rad/sec) pulse, a memory loss of the events occurring in the previous 4 sec was demonstrated. The conclusion was that the RA effect might be due to sensory activation which provided a novel stimulus that masked previous stimuli

  7. Energy deposition in TEVATRON magnets from beam losses in interaction regions

    International Nuclear Information System (INIS)

    Ginneken, A.V.

    1988-10-01

    In addition to interacting in the detector, particles produced at an interaction region also deposit energy, with less desirable consequences, in magnets and other components of the accelerator. This note briefly assesses the damage potential of these (essentially unavoidable) beam losses from the viewpoint of quenching of superconducting magnets in an upgraded Tevatron, specifically for the 1 TeV p-/ovrreverse arrowstring/p option with a luminosity of 10 31 cm/sup - 2/ sec -1 , through the results carry more generality. Related issues such as radiation damage to detector electronics or other components are not addressed here. These are thought to be less problematic at the Tevatron, as in thus far supported by operational experience. 8 refs., 10 figs

  8. Capture from pair production as a beam loss mechanism for heavy ions at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Feinberg, B.; Belkacem, A.; Claytor, N.; Dinneen, T.; Gould, H. [Lawrence Berkeley National Lab., CA (United States). Accelerator and Fusion Research Div.

    1997-05-01

    Electron capture from electron-positron pair production is predicted to be a major source of beam loss for the heaviest ions at RHIC. Achieving the highest luminosity thus requires an understanding of the capture process. The authors report measurements of this process at Brookhaven National Laboratory`s AGS using 10.8 GeV/nucleon Au{sup 79+} projectiles on Au targets. Capture from pair production is a process in which the very high electromagnetic field involved in the collision of two relativistic heavy ions results in the production of an electron-positron pair with the capture of the electron by one of the ions. There are many theoretical papers published on capture from pair production with discrepancies between predicted cross sections. The experimental results are compared to theory and to previous experiments at 1 GeV/nucleon. The implications of extrapolations to RHIC energies are presented.

  9. Retrograde amnesia produced by electron beam exposure: causal parameters and duration of memory loss. [Rats

    Energy Technology Data Exchange (ETDEWEB)

    Wheeler, T.G.; Hardy, K.A.

    1985-01-01

    The production of retrograde amnesia (RA) upon electron beam exposure has been investigated. RA production was evaluated using a single-trial avoidance task across a 10/sup 4/ dose range for 10-, 1-, and 0.1-..mu..sec pulsed exposures. The dose-response curve obtained at each pulse duration showed significant RA production. The most effective dose range was 0.1-10 rad at a dose rate of 10/sup 6/ rad/sec. By employing a 10 rad (10/sup 6/ rad/sec) pulse, a memory loss of the events occurring in the previous 4 sec was demonstrated. The conclusion was that the RA effect might be due to sensory activation which provided a novel stimulus that masked previous stimuli.

  10. Receiving beam patterns in the horizontal plane of a harbor porpoise (Phocoena phocoena)

    NARCIS (Netherlands)

    Kastelein, R.A.; Janssen, M.; Verboom, W.C.; Haan, D. de

    2005-01-01

    Receiving beam patterns of a harbor porpoise were measured in the horizontal plane, using narrow-band frequency modulated signals with center frequencies of 16, 64, and 100 kHz. Total signal duration was 1000 ms, including a 200 ms rise time and 300 ms fall time. The harbor porpoise was trained to

  11. Ion and electron beam effects on kinetic Alfven wave with general loss-cone distribution function-kinetic approach

    International Nuclear Information System (INIS)

    Shukla, Nidhi; Mishra, Ruchi; Varma, P; Tiwari, M S

    2008-01-01

    This work studies the effect of ion and electron beam on kinetic Alfven wave (KAW) with general loss-cone distribution function. The kinetic theory has been adopted to evaluate the dispersion relation and damping rate of the wave in the presence of loss-cone distribution indices J. The variations in wave frequency ω and damping rate with perpendicular wave number k perpendicular ρ i (k perpendicular is perpendicular wave number and ρ i is ion gyroradius) and parallel wave number k parallel are studied. It is found that the distribution index J and ion beam velocity enhance the wave frequency at lower k perpendicular ρ i , whereas the electron beam velocity enhances the wave frequency at higher k perpendicular ρ i . The calculated values of frequency correspond to the observed values in the range 0.1-4 Hz. Increase in damping rate due to higher distribution indices J and ion beam velocity is observed. The effect of electron beam is to reduce the damping rate at higher k perpendicular ρ i . The plasma parameters appropriate to plasma sheet boundary layer are used. The results may explain the transfer of Poynting flux from the magnetosphere to the ionosphere. It is also found that in the presence of the loss-cone distribution function the ion beam becomes a sensitive parameter to reduce the Poynting flux of KAW propagating towards the ionosphere

  12. Commissioning and first operational experience of the ATLAS beam conditions and loss monitors based on pCVD diamond sensors

    Science.gov (United States)

    Gorišek, A.; Atlas Bcm Collaboration

    2010-05-01

    Primary goal of ATLAS Beam Condition and Beam Loss Monitors based on polycrystalline chemical vapor deposition (pCVD) diamonds is to protect the ATLAS inner silicon detectors from beam incidents. The sensor material was chosen due to its radiation hardness. The first one, ATLAS Beam Condition Monitor (BCM) utilizes fast front end amplifiers and processing electronics capable of handling events in real time and storing data in circular buffer thousand LHC turns deep for post-mortem analysis. There are eight detectors installed, four on each side of interaction point (IP) of ATLAS spectrometer. Due to fast timing and high efficiency for detecting single particles BCM will also provide valuable information on instantaneous luminosity. The second system, ATLAS Beam Loss Monitor (BLM) is adopted after similar system developed in the LHC beam instrumentation group with detectors replaced with the pCVD diamonds, with six of such detectors on each side of the IP. In this contribution the design and commissioning of the above two systems will be presented and results of the first operational experience will be shown as obtained in combined ATLAS framework both with the first LHC beam and commissioning cosmic ray runs.

  13. A Cherenkov-based Beam Loss Scintillator system for beam, background and online luminosity monitoring at the LHCb experiment at CERN

    CERN Document Server

    Alessio, F; Jacobsson, R

    2013-01-01

    The installation of a scintillator-based system in the LHCb cavern was initially proposed in order to observe injection problems around the LHCb interaction region. Thanks to the fact that LHCb had already developed a custom-made electronics board (BPIM) for the LHCb beam pickups and global LHCb timing monitoring, a complete, inexpensive but flexible and robust system was quickly developed and installed few cm from the beam pipe just in front of the LHCb VELO detector in time for the very first beams injected in the LHC. The current and final system – commonly referred to as Beam Loss Scintillator (BLS) system - ultimately played a central role in the fast beam, background and online luminosity monitoring at LHCb. In this paper, the features of the detector – based on quartz radiator and Cherenkov light - are described, including the functionalities that the system acquired during the proton-proton physics programmes in 2009- 2013 thanks to its flexibility, reliability and sensitivity to beam hal...

  14. Pattern of alveolar bone loss and reliability of measurements with the radiographic technique

    Energy Technology Data Exchange (ETDEWEB)

    Rise, J.; Albandar, J.M.

    1988-01-01

    The purposes of this paper were to study the pattern of bone loss among different teeth at the individual level and to study the effect of using different aggregated units of analysis on measurement error. Bone loss was assessed in standardized periapical radiographs from 293 subjects (18-68 years), and the mean bone loss score for each tooth type was calculated. These were then correlated by means of factor analysis to study the bone loss pattern. Reliability (measurement error) was studied by the internal consistency and the test-retest methods. The pattern of bone loss showed a unidimensional pattern, indicating that any tooth will work equally well as a dependent variable for epidemiologic descriptive purposes. However, a more thorough analysis also showed a multidimensional pattern in terms of four dimensions, which correspond to four tooth groups: incisors, upper premolars, lower premolars and molars. The four dimensions accounted for 80% of the toal variance. The multidimensional pattern may be important for the modeling of bone loss; thus different models may explain the four dimension (indices) used as dependent variables. The reliability (internal consistency) of the four indices was satisfactory. By the test-retest method, reliability was higher when the more aggregated unit (the individual) was used.

  15. Pattern of alveolar bone loss and reliability of measurements with the radiographic technique

    International Nuclear Information System (INIS)

    Rise, J.; Albandar, J.M.

    1988-01-01

    The purposes of this paper were to study the pattern of bone loss among different teeth at the individual level and to study the effect of using different aggregated units of analysis on measurement error. Bone loss was assessed in standardized periapical radiographs from 293 subjects (18-68 years), and the mean bone loss score for each tooth type was calculated. These were then correlated by means of factor analysis to study the bone loss pattern. Reliability (measurement error) was studied by the internal consistency and the test-retest methods. The pattern of bone loss showed a unidimensional pattern, indicating that any tooth will work equally well as a dependent variable for epidemiologic descriptive purposes. However, a more thorough analysis also showed a multidimensional pattern in terms of four dimensions, which correspond to four tooth groups: incisors, upper premolars, lower premolars and molars. The four dimensions accounted for 80% of the toal variance. The multidimensional pattern may be important for the modeling of bone loss; thus different models may explain the four dimension (indices) used as dependent variables. The reliability (internal consistency) of the four indices was satisfactory. By the test-retest method, reliability was higher when the more aggregated unit (the individual) was used

  16. Pattern of liquid crystalline droplets induced by two beam interference in azobenzene derivative

    Science.gov (United States)

    Czajkowski, Maciej; Dradrach, Klaudia; Bartkiewicz, Stanislaw; Galewski, Zbigniew

    2013-10-01

    A pattern of liquid crystalline droplets dispersed in the isotropic liquid can be formed during illumination by two interfering laser beams in certain range of the temperature and the light intensity. Azobenzene derivative substituted by long alkyl and alkoxy chains exhibiting smectic phases has been used for the study. The pattern can be reversibly erased and rewritten by shutting down and opening of the interfering beams. Polarized microscope images have shown the formation of numerous liquid crystalline droplets at bright regions of the interference fringes. Influence of the temperature and the light intensity has been studied by measuring the diffraction efficiency dynamics. Photothermal and photoorientational mechanisms of the formation of liquid crystalline droplets pattern have been proposed and discussed.

  17. Synthesis of Steered Flat-top Beam Pattern Using Evolutionary Algorithm

    Directory of Open Access Journals (Sweden)

    D. Mandal

    2016-12-01

    Full Text Available In this paper a pattern synthesis method based on Evolutionary Algorithm is presented. A Flat-top beam pattern has been generated from a concentric ring array of isotropic elements by finding out the optimum set of elements amplitudes and phases using Differential Evolution algorithm. The said pattern is generated in three predefined azimuth planes instate of a single phi plane and also verified for a range of azimuth plane for the same optimum excitations. The main beam is steered to an elevation angle of 30 degree with lower peak SLL and ripple. Dynamic range ratio (DRR is also being improved by eliminating the weakly excited array elements, which simplify the design complexity of feed networks.

  18. Pattern of bone loss in dry Mandibles of individuals who died before ...

    African Journals Online (AJOL)

    Pattern of bone loss in dry Mandibles of individuals who died before 1957. ... The total mean bone loss for all teeth was 2.51 (SD 1.15) with a range of 0.85-5.80. ... Thus susceptibility to periodontal disease is evident in a small proportion of individuals even in populations not exposed to modern diet and formal dental ...

  19. Soil losses from typic cambisols and red latosol as related to three erosive rainfall patterns

    Directory of Open Access Journals (Sweden)

    Regimeire Freitas Aquino

    2013-02-01

    Full Text Available Rainfall erosivity is one of the main factors related to water erosion in the tropics. This work focused on relating soil loss from a typic dystrophic Tb Haplic Cambisol (CXbd and a typic dystrophic Red Latosol (LVdf to different patterns of natural erosive rainfall. The experimental plots of approximately 26 m² (3 x 8.67 m consisted of a CXbd area with a 0.15 m m-1 slope and a LVdf area with 0.12 m m-1 slope, both delimited by galvanized plates. Drainpipes were installed at the lower part of these plots to collect runoff, interconnected with a Geib or multislot divisor. To calculate erosivity (EI30, rainfall data, recorded continuously at a weather station in Lavras, were used. The data of erosive rainfall events were measured (10 mm precipitation intervals, accuracy 0.2 mm, 24 h period, 20 min intervals, characterized as rainfall events with more than 10 mm precipitation, maximum intensity > 24 mm h-1 within 15 min, or kinetic energy > 3.6 MJ, which were used in this study to calculate the rainfall erosivity parameter, were classified according to the moment of peak precipitation intensity in advanced, intermediate and delayed patterns. Among the 139 erosive rainfall events with CXbd soil loss, 60 % were attributed to the advanced pattern, with a loss of 415.9 Mg ha-1, and total losses of 776.0 Mg ha-1. As for the LVdf, of the 93 erosive rainfall events with soil loss, 58 % were listed in the advanced pattern, with 37.8 Mg ha-1 soil loss and 50.9 Mg ha-1 of total soil loss. The greatest soil losses were observed in the advanced rain pattern, especially for the CXbd. From the Cambisol, the soil loss per rainfall event was greatest for the advanced pattern, being influenced by the low soil permeability.

  20. OPERATIONAL EXPERIENCE WITH FAST FIBER-OPTIC BEAM LOSS MONITORS FOR THE ADVANCED PHOTON SOURCE STORAGE RING SUPERCONDUCTING UNDULATORS

    Energy Technology Data Exchange (ETDEWEB)

    Dooling, J.; Harkay, K.; Sajaev, V.; Shang, H.

    2017-06-25

    Fast fiber-optic (FFO) beam loss monitors (BLMs) installed with the first two superconducting undulators (SCUs) in the Advanced Photon Source storage ring have proven to be a useful diagnostic for measuring deposited charge (energy) during rapid beam loss events. The first set of FFOBLMs were installed outside the cryostat of the short SCU, a 0.33-m long device, above and below the beam centerline. The second set are mounted with the first 1.1-mlong SCU within the cryostat, on the outboard and inboard sides of the vacuum chamber. The next 1.1-m-long SCU is scheduled to replace the short SCU later in 2016 and will be fitted with FFOBLMs in a manner similar to original 1.1-m device. The FFOBLMs were employed to set timing and voltage for the abort kicker (AK) system. The AK helps to prevent quenching of the SCUs during beam dumps [1] by directing the beam away from the SC magnet windings. The AK is triggered by the Machine Protection System (MPS). In cases when the AK fails to prevent quenching, the FFOBLMs show that losses often begin before detection by the MPS.

  1. New data acquisition system for beam loss monitor used in J-PARC main ring

    Science.gov (United States)

    Satou, K.; Toyama, T.; Kamikubota, N.; Yoshida, S.; Matsushita, J.; Wakita, T.; Sugiyama, M.; Morino, T.

    2018-04-01

    A new data acquisition system has been developed continually as a part of the development of a new beam loss monitor (BLM) system for the J-PARC main ring. This development includes a newly designed front-end isolation amp that uses photo-couplers and a VME-based new analog-to-digital converter (ADC) system. Compared to the old amp, the new amp has a 10 times higher conversion impedance for the input current to the output voltage; this value is 1 M Ω. Moreover, the bandwidth was improved to from DC to 50 kHz, which is about two orders of magnitude greater than the previously used bandwidth. The theoretical estimations made in this study roughly agree with the frequency response obtained for the new system. The new ADC system uses an on-board field-programmable gate array chip for signal processing. By replacing the firmware of this chip, changes pertaining to future accelerator upgrade plans may be introduced into the new ADC system; in addition, the ADC system can be used in other applications. The sampling speed of the system is 1 MS/s, and it exhibits a 95 dBc spurious-free dynamic range and 16.5 effective number of bits. The obtained waveform and integrated charge data are compared with two reference levels in the ADC system. If the data exceeds the reference level, the system generates an alarm to dump the beams. By using the new data acquisition system, it was proved that the new BLM system shows a wide dynamic range of 160 dB. In this study, the details of the new data acquisition system are described.

  2. Focused-ion beam patterning of organolead trihalide perovskite for subwavelength grating nanophotonic applications

    KAUST Repository

    Alias, Mohd Sharizal

    2015-07-30

    The coherent amplified spontaneous emission and high photoluminescence quantum efficiency of organolead trihalide perovskite have led to research interest in this material for use in photonic devices. In this paper, the authors present a focused-ion beam patterning strategy for methylammonium lead tribromide (MAPbBr3) perovskite crystal for subwavelength grating nanophotonic applications. The essential parameters for milling, such as the number of scan passes, dwell time, ion dose, ion current, ion incident angle, and gas-assisted etching, were experimentally evaluated to determine the sputtering yield of the perovskite. Based on our patterning conditions, the authors observed that the sputtering yield ranged from 0.0302 to 0.0719 μm3/pC for the MAPbBr3 perovskite crystal. Using XeF2 for the focused-ion beam gas-assisted etching, the authors determined that the etching rate was reduced to between 0.40 and 0.97, depending on the ion dose, compared with milling with ions only. Using the optimized patterning parameters, the authors patterned binary and circular subwavelength grating reflectors on the MAPbBr3 perovskite crystal using the focused-ion beam technique. Based on the computed grating structure with around 97% reflectivity, all of the grating dimensions (period, duty cycle, and grating thickness) were patterned with nanoscale precision (>±3 nm), high contrast, and excellent uniformity. Our results provide a platform for utilizing the focused-ion beam technique for fast prototyping of photonic nanostructures or nanodevices on organolead trihalide perovskite.

  3. Severe signal loss in diamond beam loss monitors in high particle rate environments by charge trapping in radiation-induced defects

    CERN Document Server

    Kassel, Florian; Dabrowski, Anne; de Boer, Wim

    2016-01-01

    The beam condition monitoring leakage (BCML) system is a beam monitoring device in the compact muon solenoid (CMS) experiment at the large hadron collider (LHC). As detectors 32 poly-crystalline (pCVD) diamond sensors are positioned in rings around the beam pipe. Here, high particle rates occur from the colliding beams scattering particles outside the beam pipe. These particles cause defects, which act as traps for the ionization, thus reducing the charge collection efficiency (CCE). However, the loss in CCE was much more severe than expected from low rate laboratory measurements and simulations, especially in single-crystalline (sCVD) diamonds, which have a low initial concentration of defects. The reason why in real experiments the CCE is much worse than in laboratory experiments is related to the ionization rate. At high particle rates the trapping rate of the ionization is so high compared with the detrapping rate, that space charge builds up. This space charge reduces locally the internal electric field,...

  4. Spatial and Temporal Patterns of Land Loss in Mississippi River Delta

    Science.gov (United States)

    Roy, S.; Edmonds, D. A.; Robeson, S. M.; Ortiz, A. C.; Nienhuis, J.

    2017-12-01

    Land loss across the Louisiana coast is predicted to exceed 10,000 km2 by 2100. An estimated 18-24 billion tons of sediment is needed to offset land loss, but available sediment supply from the Mississippi River falls short. As a result, coastal restoration plans must target certain areas, which highlight the importance of understanding the processes and patterns of land loss. In this study, we use remote sensing to investigate and quantify land loss patterns, as well as the corresponding morphology of the land segments that are lost. Using Google Earth Engine, we combined over 10,000 time-series Landsat imagery in the Mississippi River Delta to create twelve, three-year composites from 1983 to 2016. We then spectrally unmixed each pixel into land and water percentages, and create land-water binaries. Stratifying by hydrologic unit code boundaries and local subsidence rates, we analyze the land loss pixels using landscape metrics. Our results show that the total loss from 1983-2016 for our area of interest was 908.02 km2 (loss of 5.84%) and total land area was 6855.63 km2 (49.97 % of total area) in 2016 compared to 7763.65 km2 (44.13%) in 1983 consistent with previous estimates for our study area. Land loss pixels have a low patch density (mean of 4.80 patches/ha) and high aggregation indices (mean of 47.15), which indicates that land-loss pixels tend to clump together. The shape index of these clumped pixels are also low (mean of 2.32), which points towards long, narrow patches and edges. Local indicator of spatial autocorrelation (LISA) areas was applied to determine areas of high positive autocorrelation within the loss pixels which reinforced loss across edges. Based on spatial metrics and subsidence grid based analysis on the temporal pattern of land loss pixels we find that i) land change (both growth and loss pixels) occurs along the marsh, lake and coastal edges rather than inland; ii) subsidence, though positively correlated with landloss, is no longer the

  5. Female pattern hair loss, sebum excretion and the end-organ response to androgens.

    Science.gov (United States)

    Birch, M P; Lashen, H; Agarwal, S; Messenger, A G

    2006-01-01

    Although female pattern hair loss can be a feature of hyperandrogenism, many women with hair loss show no clinical or biochemical features of androgen excess. It is possible that hair loss in nonhyperandrogenic women is due to a high level of response to androgens by scalp hair follicles. In this study we explored this idea using sebum excretion as a marker of the cutaneous end-organ response to androgens. To test the hypothesis that hair loss in nonhyperandrogenic women is due to an increased cutaneous end-organ response to androgens. We studied 100 women, 41 with female pattern hair loss (without hirsutism), 29 with hirsutism (with and without scalp hair loss) and 30 subjects without hair problems. We measured hair density on the frontal scalp, forehead sebum excretion, serum free androgen index (FAI), and body mass index (BMI). The mean FAI was significantly raised in hirsute women compared with nonhirsute women (P women with and without hair loss. The mean BMI was also significantly elevated in hirsute women (P women with and without hair loss. The mean sebum excretion was higher in hirsute women than nonhirsute women but the difference was not statistically significant. There was no difference in sebum excretion between nonhirsute women with and without hair loss. There was no correlation between hair density and sebum excretion. Our results show that sebum excretion is not elevated in women with female pattern hair loss. This may indicate that different androgen-response pathways operate in controlling hair growth and sebum excretion. The alternative explanation is that nonandrogenic mechanisms are involved in mediating hair loss in some women.

  6. Measurement profiles of nano-scale ion beam for optimized radiation energy losses

    International Nuclear Information System (INIS)

    Woo, T.H.; Cho, H.S.

    2011-01-01

    The behavior of charged particles is investigated for nano-scale ion beam therapy using a medical accelerator. Computational work is performed for the Bragg-peak simulation, which is focused on human organ material of pancreas and thyroid. The Results show that the trends of the dose have several different kinds of distributions. Before constructing a heavy ion collider, this study can give us the reliability of the therapeutic effect. Realistic treatment using human organs is calculated in a simple and cost effective manner using the computational code, the Stopping and Range of Ions in Matter 2008 (SRIM 2008). Considering the safety of the therapy, it is suggested to give a patient orient planning of the cancer therapy. The energy losses in ionization and phonon are analyzed, which are the behaviors in the molecular level nano-scopic investigation. The different fluctuations are shown at 150 MeV, where the lowest temperature is found in proton and pancreas case. Finally, the protocol for the radiation therapy is constructed by the simulation in which the procedure for a better therapy is selected. An experimental measurement incorporated with the simulations could be programmed by this protocol.

  7. IDENTIFIKASI PROFIL DASAR LAUT MENGGUNAKAN INSTRUMEN SIDE SCAN SONAR DENGAN METODE BEAM PATTERN DISCRETE-EQUI-SPACED UNSHADED LINE ARRAY

    Directory of Open Access Journals (Sweden)

    Muhammad Zainuddin Lubis

    2017-05-01

    Full Text Available Laut Punggur merupakan laut yang terletak di Batam, Kepulauan Riau yang mempunyai beragam habitat objek,dan bentuk struktur bawah laut yang memiliki dinamika laut yang sangat tinggi. Side scan sonar (SSS merupakan instrumen pengembangan sistem sonar yang mampu menunjukkan dalam gambar dua dimensional permukaan dasar laut dengan kondisi kontur, topografi, dan target secara bersamaan. Metode Beam Pattern Discrete-Equi-Spaced Unshaded Line Array digunakan untuk menghitung beam pattern dua dimensi yang tergantung pada sudut dari gelombang suara yang masuk dari sumbu array yang diterima tergantung pada sudut di mana sinar suara pada array. Penelitian ini dilakukan pada Desember 2016 di laut Punggur,Batam, Kepulauan Riau-Indonesia, dengan koordinat 104 ° 08,7102 E dan 1° 03,2448 N sampai 1 ° 03.3977 N dan 104 ° 08,8133 E, menggunakan instrumen Side Scan Sonar C-Max CM2 Tow fish dengan frekuensi 325 kHz. Hasil yang diperoleh dari perekaman terdapat 7 target, dan Beam pattern dari metode Beam Discrete-Equi-Spaced Unshaded Line Array target 4 memiliki nilai tertinggi pada directivity Pattern yaitu 21.08 dB. Hasil model beam pattern ini memiliki nilai pusat pada incidence angle (o terhadap Directivity pattern (dB tidak berada di nilai 0 ataupun pada pusat beam pattern yang dihasilkan pada target 6 dengan nilai incident angle -1.5 o dan 1.5o mengalami penurunan hingga -40 dB. Karakteristik sedimen dasar perairan di laut punggur ditemukan lebih banyak pasir. Hasil metode Beam Discrete-Equi-Spaced Unshaded Line Array ditemukan bangkai kapal tenggelam.Kata Kunci: Side Scan Sonar, Beam Pattern Discrete-Equi-Spaced Unshaded Line Array, Incidence angle, Directivity pattern IDENTIFICATION OF SEABED PROFILE USING SIDE SCAN SONAR INSTRUMENT WITH PATTERN DISCRETE-EQUI-SPACED UNSHADED LINE ARRAY METHODRiau Islands is an island that has a variety of habitat objects, and forms of submarine structures that have a very high ocean dynamics, Punggur Sea is the sea

  8. Nonlinear ripple dynamics on amorphous surfaces patterned by ion beam sputtering.

    Science.gov (United States)

    Muñoz-García, Javier; Castro, Mario; Cuerno, Rodolfo

    2006-03-03

    Erosion by ion-beam sputtering (IBS) of amorphous targets at off-normal incidence frequently produces a (nanometric) rippled surface pattern, strongly resembling macroscopic ripples on aeolian sand dunes. A suitable generalization of continuum descriptions of the latter allows us to describe theoretically for the first time the main nonlinear features of ripple dynamics by IBS, namely, wavelength coarsening and nonuniform translation velocity, that agree with similar results in experiments and discrete models. These properties are seen to be the anisotropic counterparts of in-plane ordering and (interrupted) pattern coarsening in IBS experiments on rotating substrates and at normal incidence.

  9. Patterns of functional vision loss in glaucoma determined with archetypal analysis

    Science.gov (United States)

    Elze, Tobias; Pasquale, Louis R.; Shen, Lucy Q.; Chen, Teresa C.; Wiggs, Janey L.; Bex, Peter J.

    2015-01-01

    Glaucoma is an optic neuropathy accompanied by vision loss which can be mapped by visual field (VF) testing revealing characteristic patterns related to the retinal nerve fibre layer anatomy. While detailed knowledge about these patterns is important to understand the anatomic and genetic aspects of glaucoma, current classification schemes are typically predominantly derived qualitatively. Here, we classify glaucomatous vision loss quantitatively by statistically learning prototypical patterns on the convex hull of the data space. In contrast to component-based approaches, this method emphasizes distinct aspects of the data and provides patterns that are easier to interpret for clinicians. Based on 13 231 reliable Humphrey VFs from a large clinical glaucoma practice, we identify an optimal solution with 17 glaucomatous vision loss prototypes which fit well with previously described qualitative patterns from a large clinical study. We illustrate relations of our patterns to retinal structure by a previously developed mathematical model. In contrast to the qualitative clinical approaches, our results can serve as a framework to quantify the various subtypes of glaucomatous visual field loss. PMID:25505132

  10. Crossover patterning by the beam-film model: analysis and implications.

    Directory of Open Access Journals (Sweden)

    Liangran Zhang

    2014-01-01

    Full Text Available Crossing-over is a central feature of meiosis. Meiotic crossover (CO sites are spatially patterned along chromosomes. CO-designation at one position disfavors subsequent CO-designation(s nearby, as described by the classical phenomenon of CO interference. If multiple designations occur, COs tend to be evenly spaced. We have previously proposed a mechanical model by which CO patterning could occur. The central feature of a mechanical mechanism is that communication along the chromosomes, as required for CO interference, can occur by redistribution of mechanical stress. Here we further explore the nature of the beam-film model, its ability to quantitatively explain CO patterns in detail in several organisms, and its implications for three important patterning-related phenomena: CO homeostasis, the fact that the level of zero-CO bivalents can be low (the "obligatory CO", and the occurrence of non-interfering COs. Relationships to other models are discussed.

  11. Utilization Patterns and User Characteristics of an Ad Libitum Internet Weight Loss Program

    OpenAIRE

    Binks, Martin; van Mierlo, Trevor

    2010-01-01

    Background The Internet holds promise for the delivery of evidence-based weight loss treatment to underserved populations. However, most studies do not reflect the more naturalistic and common ad libitum, or freely at will, use of the Internet. Randomized clinical trials, for example, typically include at least some direct contact with participants and often have restrictive selection criteria. There is a paucity of research examining utilization patterns of online weight loss programs, parti...

  12. Bending, longitudinal and torsional wave transmission on Euler-Bernoulli and Timoshenko beams with high propagation losses.

    Science.gov (United States)

    Wang, X; Hopkins, C

    2016-10-01

    Advanced Statistical Energy Analysis (ASEA) is used to predict vibration transmission across coupled beams which support multiple wave types up to high frequencies where Timoshenko theory is valid. Bending-longitudinal and bending-torsional models are considered for an L-junction and rectangular beam frame. Comparisons are made with measurements, Finite Element Methods (FEM) and Statistical Energy Analysis (SEA). When beams support at least two local modes for each wave type in a frequency band and the modal overlap factor is at least 0.1, measurements and FEM have relatively smooth curves. Agreement between measurements, FEM, and ASEA demonstrates that ASEA is able to predict high propagation losses which are not accounted for with SEA. These propagation losses tend to become more important at high frequencies with relatively high internal loss factors and can occur when there is more than one wave type. At such high frequencies, Timoshenko theory, rather than Euler-Bernoulli theory, is often required. Timoshenko theory is incorporated in ASEA and SEA using wave theory transmission coefficients derived assuming Euler-Bernoulli theory, but using Timoshenko group velocity when calculating coupling loss factors. The changeover between theories is appropriate above the frequency where there is a 26% difference between Euler-Bernoulli and Timoshenko group velocities.

  13. Angle-resolved conical emission spectra from filamentation in a solid with an Airy pattern and a Gaussian laser beam.

    Science.gov (United States)

    Gong, Cheng; Li, ZiXi; Hua, LinQiang; Quan, Wei; Liu, XiaoJun

    2016-09-15

    Filamentation dynamics in fused silica are investigated using an Airy pattern and a Gaussian laser beam. The angle-resolved conical emission spectra are measured and compared with the predictions of several models. Our experimental observations are consistent with the X-waves model in both cases. This indicates that both laser beams spontaneously evolve into nonlinear X-waves and suggests a universal evolution of filaments in fused silica, regardless of the initial laser beam profile.

  14. Process time optimization of robotic remote laser cutting by utilizing customized beam patterns and redundancy space task sequencing

    DEFF Research Database (Denmark)

    Villumsen, Sigurd

    This dissertation is written as a part of the ROBOCUT project which concerns the development of a new laser cutting technology that seeks to increase the performance of traditional and remote laser cutting by using beam shaping technologies. The resulting customized beam patterns are obtained...

  15. Habitat loss, not fragmentation, drives occurrence patterns of Canada lynx at the southern range periphery.

    Directory of Open Access Journals (Sweden)

    Megan L Hornseth

    Full Text Available Peripheral populations often experience more extreme environmental conditions than those in the centre of a species' range. Such extreme conditions include habitat loss, defined as a reduction in the amount of suitable habitat, as well as habitat fragmentation, which involves the breaking apart of habitat independent of habitat loss. The 'threshold hypothesis' predicts that organisms will be more affected by habitat fragmentation when the amount of habitat on the landscape is scarce (i.e., less than 30% than when habitat is abundant, implying that habitat fragmentation may compound habitat loss through changes in patch size and configuration. Alternatively, the 'flexibility hypothesis' predicts that individuals may respond to increased habitat disturbance by altering their selection patterns and thereby reducing sensitivity to habitat loss and fragmentation. While the range of Canada lynx (Lynx canadensis has contracted during recent decades, the relative importance of habitat loss and habitat fragmentation on this phenomenon is poorly understood. We used a habitat suitability model for lynx to identify suitable land cover in Ontario, and contrasted occupancy patterns across landscapes differing in cover, to test the 'threshold hypothesis' and 'flexibility hypothesis'. When suitable land cover was widely available, lynx avoided areas with less than 30% habitat and were unaffected by habitat fragmentation. However, on landscapes with minimal suitable land cover, lynx occurrence was not related to either habitat loss or habitat fragmentation, indicating support for the 'flexibility hypothesis'. We conclude that lynx are broadly affected by habitat loss, and not specifically by habitat fragmentation, although occurrence patterns are flexible and dependent on landscape condition. We suggest that lynx may alter their habitat selection patterns depending on local conditions, thereby reducing their sensitivity to anthropogenically-driven habitat

  16. Habitat loss, not fragmentation, drives occurrence patterns of Canada lynx at the southern range periphery.

    Science.gov (United States)

    Hornseth, Megan L; Walpole, Aaron A; Walton, Lyle R; Bowman, Jeff; Ray, Justina C; Fortin, Marie-Josée; Murray, Dennis L

    2014-01-01

    Peripheral populations often experience more extreme environmental conditions than those in the centre of a species' range. Such extreme conditions include habitat loss, defined as a reduction in the amount of suitable habitat, as well as habitat fragmentation, which involves the breaking apart of habitat independent of habitat loss. The 'threshold hypothesis' predicts that organisms will be more affected by habitat fragmentation when the amount of habitat on the landscape is scarce (i.e., less than 30%) than when habitat is abundant, implying that habitat fragmentation may compound habitat loss through changes in patch size and configuration. Alternatively, the 'flexibility hypothesis' predicts that individuals may respond to increased habitat disturbance by altering their selection patterns and thereby reducing sensitivity to habitat loss and fragmentation. While the range of Canada lynx (Lynx canadensis) has contracted during recent decades, the relative importance of habitat loss and habitat fragmentation on this phenomenon is poorly understood. We used a habitat suitability model for lynx to identify suitable land cover in Ontario, and contrasted occupancy patterns across landscapes differing in cover, to test the 'threshold hypothesis' and 'flexibility hypothesis'. When suitable land cover was widely available, lynx avoided areas with less than 30% habitat and were unaffected by habitat fragmentation. However, on landscapes with minimal suitable land cover, lynx occurrence was not related to either habitat loss or habitat fragmentation, indicating support for the 'flexibility hypothesis'. We conclude that lynx are broadly affected by habitat loss, and not specifically by habitat fragmentation, although occurrence patterns are flexible and dependent on landscape condition. We suggest that lynx may alter their habitat selection patterns depending on local conditions, thereby reducing their sensitivity to anthropogenically-driven habitat alteration.

  17. Large patternable metal nanoparticle sheets by photo/e-beam lithography

    Science.gov (United States)

    Saito, Noboru; Wang, Pangpang; Okamoto, Koichi; Ryuzaki, Sou; Tamada, Kaoru

    2017-10-01

    Techniques for micro/nano-scale patterning of large metal nanoparticle sheets can potentially be used to realize high-performance photoelectronic devices because the sheets provide greatly enhanced electrical fields around the nanoparticles due to localized surface plasmon resonances. However, no single metal nanoparticle sheet currently exists with sufficient durability for conventional lithographical processes. Here, we report large photo and/or e-beam lithographic patternable metal nanoparticle sheets with improved durability by incorporating molecular cross-linked structures between nanoparticles. The cross-linked structures were easily formed by a one-step chemical reaction; immersing a single nanoparticle sheet consisting of core metals, to which capping molecules ionically bond, in a dithiol ethanol solution. The ligand exchange reaction processes were discussed in detail, and we demonstrated 20 μm wide line and space patterns, and a 170 nm wide line of the silver nanoparticle sheets.

  18. Comparison of three different concepts of high dynamic range and dependability optimised current measurement digitisers for beam loss systems

    CERN Document Server

    Viganò, W; Effinger, E; Venturini, G G; Zamantzas, C

    2012-01-01

    Three Different Concepts of High Dynamic Range and Dependability Optimised Current Measurement Digitisers for Beam Loss Systems will be compared on this paper. The first concept is based on Current to Frequency Conversion, enhanced with an ADC for extending the dynamic range and decreasing the response time. A summary of 3 years’ worth of operational experience with such a system for LHC beam loss monitoring will be given. The second principle is based on an Adaptive Current to Frequency Converter implemented in an ASIC. The basic parameters of the circuit are discussed and compared with measurements. Several measures are taken to harden both circuits against single event effects and to make them tolerant for operation in radioactive environments. The third circuit is based on a Fully Differential Integrator for enhanced dynamic range, where laboratory and test installation measurements will be presented. All circuits are designed to avoid any dead time in the acquisition and have reliability and fail safe...

  19. Calculation of abort thresholds for the Beam Loss Monitoring System of the Large Hadron Collider at CERN

    CERN Document Server

    Nemcic, Martin; Dehning, Bernd

    The Beam Loss Monitoring (BLM) System is one of the most critical machine protection systems for the Large Hadron Collider (LHC) at the European Organization for Nuclear Research (CERN), Switzerland. Its main purpose is to protect the superconducting magnets from quenches and other equipment from damage by requesting a beam abort when the measured losses exceed any of the predefined threshold levels. The system consist of circa 4000 ionization chambers which are installed around the 27 kilometres ring (LHC). This study aims to choose a technical platform and produce a system that addresses all of the limitations with the current system that is used for the calculation of the LHC BLM abort threshold values. To achieve this, a comparison and benchmarking of the Java and .NET technical platforms is performed in order to establish the most suitable solution. To establish which technical platform is a successful replacement of the current abort threshold calculator, comparable prototype systems in Java and .NET we...

  20. Beam-Loss Driven Design Optimization for the Spallation Neutron Source (SNS) Ring

    International Nuclear Information System (INIS)

    Wei, J.

    1999-01-01

    This paper summarizes three-state design optimization for the Spallation Neutron Source (SNS) ring: linear machine design (lattice, aperture, injection, magnet field errors and misalignment), beam core manipulation (painting, space charge, instabilities, RF requirements), and beam halo consideration (collimation, envelope variation, e-p issues etc.)

  1. Fabrication of low-loss silicon-on-oxidized-porous-silicon strip waveguide using focused proton-beam irradiation

    OpenAIRE

    Teo, EJ; Bettiol, AA; Yang, P; Breese, MBH; Xiong, BQ; Mashanovich, GZ; Headley, WR; Reed, GT

    2009-01-01

    we have successfully fabricated low-loss silicon-on-oxidized-porous-silicon (SOPS) strip waveguides with high-index contrast using focused proton-beam irradiation and electrochemical etching. Smooth surface quality with rms roughness of 3.1 nm is achieved for a fluence of 1 x 10(15)/cm(2) after postoxidation treatment. Optical characterization at a wavelength of 1550 nm shows a loss of 1.1 +/- 0.4 dB/cm and 1.2 +/- 0.4 dB/cm in TE and TM polarization respectively, which we believe is the lowe...

  2. Analysis of sub-bandgap losses in TiO2 coating deposited via single and dual ion beam deposition

    Czech Academy of Sciences Publication Activity Database

    Žídek, Karel; Hlubuček, Jiří; Horodyská, Petra; Budasz, Jiří; Václavík, Jan

    2017-01-01

    Roč. 626, March (2017), s. 60-65 ISSN 0040-6090 R&D Projects: GA MŠk(CZ) LO1206 Institutional support: RVO:61389021 Keywords : Ion beam deposition * Titanium dioxide * Optical coating * Sub-bandgap losses * Urbach tail Subject RIV: BH - Optics, Masers, Lasers OBOR OECD: Optics (including laser optics and quantum optics) Impact factor: 1.879, year: 2016 http://www.sciencedirect.com/science/article/pii/S0040609017301256

  3. External beam radiation for retinoblastoma: Results, patterns of failure, and a proposal for treatment guidelines

    International Nuclear Information System (INIS)

    Hernandez, J. Carlos; Brady, Luther W.; Shields, Jerry A.; Shields, Carol L.; Potter, Patrick de; Karlsson, Ulf L.; Markoe, Arnold M.; Amendola, Beatriz E.; Singh, Arun

    1996-01-01

    Purpose: To analyze treatment results and patterns of failure following external beam radiation for retinoblastoma and propose treatment guidelines according to specific clinical variables. Methods and Materials: We analyzed 27 patients (34 eyes) with retinoblastoma who received external beam radiation as initial treatment at Hahnemann University Hospital from October 1980 to December 1991 and have been followed for at least 1 year. Of the 34 eyes, 14 were Groups I-II (Reese-Ellsworth classification), 7 were Group III, and 13 were Groups IV-V. Doses ranged from 34.5-49.5 Gy (mean 44.3 Gy, median 45 Gy) in 1.5-2.0 Gy fractions generally delivered through anterior and lateral wedged pair fields. Results: At a mean follow up of 35.2 months (range 12-93 months), local tumor control was obtained in 44% (15 out of 34) of eyes with external beam radiation alone. Salvage therapy (plaque brachytherapy, cryotherapy, and/or photocoagulation) controlled an additional 10 eyes (29.5%), so that overall ocular survival has been 73.5%. Local tumor control with external beam radiotherapy alone was obtained in 78.5% (11 out of 14) of eyes in Groups I-II, but in only 20% (4 out of 20) of eyes in Groups III-V. A total of 67 existing tumors were identified prior to treatment in the 34 treated eyes and local control with external beam radiation alone was obtained in 87% (46 out of 53) of tumors measuring 15 mm or less and in 50% (7 out of 14) of tumors measuring more than 15 mm. When analyzing patterns of failure in the 19 eyes that relapsed, a total of 28 failure sites were identified and consisted of progression of vitreous seeds in seven instances (25% of failure sites) recurrences from previously existing tumors in 10 instances (36% of failure sites) and development of new tumors in previously uninvolved retina in 11 instances (39% of failure sites). Conclusions: 1) We find that external beam radiation to a dose of 45 Gy in fractions of 1.5 to 2.0 Gy provides adequate tumor control

  4. EUV mask pattern inspection with an advanced electron beam inspection system

    Science.gov (United States)

    Shimomura, Takeya; Inazuki, Yuichi; Tsukasa, Abe; Takikawa, Tadahiko; Morikawa, Yasutaka; Mohri, Hiroshi; Hayashi, Naoya; Wang, Fei; Ma, Long; Zhao, Yan; Kuan, Chiyan; Xiao, Hong; Jau, Jack

    2009-12-01

    Readiness of defect-free mask is one of the biggest challenges to insert extreme ultraviolet (EUV) lithography into semiconductor high volume manufacturing for 22nm half pitch (HP) node and beyond. According to ITRS roadmap updated in 2008, minimum size of defect needed to be removed is 25nm for 22nm HP node in 2013 [1]. It is necessary, therefore, to develop EUV mask pattern inspection tool being capable of detecting 25nm defect. Electron beam inspection (EBI) is one of promising tools which will be able to meet such a tight defect requirement. In this paper, we evaluated defect detection sensitivity of electron beam inspection (EBI) system developed by Hermes Microvision, Inc. (HMI) using 88nm half-pitch (HP) line-and-space (L/S) pattern and 128nm HP contact-hole (C/H) pattern EUV mask. We found the EBI system can detect 25nm defects. We, furthermore, fabricated 4 types of EUV mask structures: 1) w/ anti-reflective (AR) layer and w/ buffer layer, 2) w/ AR layer and w/o buffer layer, 3) w/o AR layer and w/ buffer layer, 4) w/o AR layer and w/o buffer layer. And the sensitivity and inspectability for the EBI were compared. It was observed that w/o AR layer structure introduce higher image contrast and lead to better inspectability, although there is no significant different in sensitivity.

  5. Neutral loss fragmentation pattern based screening for arginine-rich natural products in Xenorhabdus and Photorhabdus.

    Science.gov (United States)

    Fuchs, Sebastian W; Sachs, Christian C; Kegler, Carsten; Nollmann, Friederike I; Karas, Michael; Bode, Helge B

    2012-08-21

    Although sharing a certain degree of structural uniformity, natural product classes exhibit variable functionalities such as different amino acid or acyl residues. During collision induced dissociation, some natural products exhibit a conserved fragmentation pattern close to the precursor ion. The observed fragments result from a shared set of neutral losses, creating a unique fragmentation pattern, which can be used as a fingerprint for members of these natural product classes. The culture supernatants of 69 strains of the entomopathogenic bacteria Photorhabdus and Xenorhabdus were analyzed by MALDI-MS(2), and a database comprising MS(2) data from each strain was established. This database was scanned for concordant fragmentation patterns of different compounds using a customized software, focusing on relative mass differences of the fragment ions to their precursor ion. A novel group of related natural products comprising 25 different arginine-rich peptides from 16 different strains was identified due to its characteristic neutral loss fragmentation pattern, and the structures of eight compounds were elucidated. Two biosynthesis gene clusters encoding nonribosomal peptide synthetases were identified, emphasizing the possibility to identify a group of structurally and biosynthetically related natural products based on their neutral loss fragmentation pattern.

  6. Gas exchange patterns and water loss rates in the Table Mountain cockroach, Aptera fusca (Blattodea: Blaberidae).

    Science.gov (United States)

    Groenewald, Berlizé; Bazelet, Corinna S; Potter, C Paige; Terblanche, John S

    2013-10-15

    The importance of metabolic rate and/or spiracle modulation for saving respiratory water is contentious. One major explanation for gas exchange pattern variation in terrestrial insects is to effect a respiratory water loss (RWL) saving. To test this, we measured the rates of CO2 and H2O release ( and , respectively) in a previously unstudied, mesic cockroach, Aptera fusca, and compared gas exchange and water loss parameters among the major gas exchange patterns (continuous, cyclic, discontinuous gas exchange) at a range of temperatures. Mean , and per unit did not differ among the gas exchange patterns at all temperatures (P>0.09). There was no significant association between temperature and gas exchange pattern type (P=0.63). Percentage of RWL (relative to total water loss) was typically low (9.79±1.84%) and did not differ significantly among gas exchange patterns at 15°C (P=0.26). The method of estimation had a large impact on the percentage of RWL, and of the three techniques investigated (traditional, regression and hyperoxic switch), the traditional method generally performed best. In many respects, A. fusca has typical gas exchange for what might be expected from other insects studied to date (e.g. , , RWL and cuticular water loss). However, we found for A. fusca that expressed as a function of metabolic rate was significantly higher than the expected consensus relationship for insects, suggesting it is under considerable pressure to save water. Despite this, we found no consistent evidence supporting the conclusion that transitions in pattern type yield reductions in RWL in this mesic cockroach.

  7. Mitigating illumination gradients in a SAR image based on the image data and antenna beam pattern

    Science.gov (United States)

    Doerry, Armin W.

    2013-04-30

    Illumination gradients in a synthetic aperture radar (SAR) image of a target can be mitigated by determining a correction for pixel values associated with the SAR image. This correction is determined based on information indicative of a beam pattern used by a SAR antenna apparatus to illuminate the target, and also based on the pixel values associated with the SAR image. The correction is applied to the pixel values associated with the SAR image to produce corrected pixel values that define a corrected SAR image.

  8. A general-purpose computer program for studying ultrasonic beam patterns generated with acoustic lenses

    Science.gov (United States)

    Roberti, Dino; Ludwig, Reinhold; Looft, Fred J.

    1988-03-01

    A 3-D computer model of a piston radiator with lenses for focusing and defocusing is presented. To achieve high-resolution imaging, the frequency of the transmitted and received ultrasound must be as high as 10 MHz. Current ultrasonic transducers produce an extremely narrow beam at these high frequencies and thus are not appropriate for imaging schemes such as synthetic-aperture focus techniques (SAFT). Consequently, a numerical analysis program has been developed to determine field intensity patterns that are radiated from ultrasonic transducers with lenses. Lens shapes are described and the field intensities are numerically predicted and compared with experimental results.

  9. submitter Light Extraction From Scintillating Crystals Enhanced by Photonic Crystal Structures Patterned by Focused Ion Beam

    CERN Document Server

    Modrzynski, Pawel; Knapitsch, Arno; Kunicki, Piotr; Lecoq, Paul; Moczala, Magdalena; Papakonstantinou, Ioannis; Auffray, Etiennette

    2016-01-01

    “Photonic Crystals (PhC)” have been used in a variety of fields as a structure for improving the light extraction efficiency from materials with high index of refraction. In previous work we already showed the light extraction improvement of several PhC covered LYSO crystals in computer simulations and practical measurements. In this work, new samples are made using different materials and techniques which allows further efficiency improvements. For rapid prototyping of PhC patterns on scintillators we tested a new method using “Focused Ion Beam (FIB)” patterning. The FIB machine is a device similar to a “Scanning Electron Microscope (SEM)”, but it uses ions (mainly gallium) instead of electrons for the imaging of the samples' surface. The additional feature of FIB devices is the option of surface patterning in nano-scale which was exploited for our samples. Three samples using FIB patterning have been produced. One of them is a direct patterning of the extraction face of a 0.8×0.8×10 $mm^3$ LYS...

  10. Patterning of nanoparticulate transparent conductive ITO films using UV light irradiation and UV laser beam writing

    International Nuclear Information System (INIS)

    Solieman, A.; Moharram, A.H.; Aegerter, M.A.

    2010-01-01

    Indium tin oxide (ITO) thin film is one of the most widely used as transparent conductive electrodes in all forms of flat panel display (FPD) and microelectronic devices. Suspension of already crystalline conductive ITO nanoparticles fully dispersed in alcohol was spun, after modifying with coupling agent, on glass substrates. The low cost, simple and versatile traditional photolithography process without complication of the photoresist layer was used for patterning ITO films. Using of UV light irradiation through mask and direct UV laser beam writing resulted in an accurate linear, sharp edge and very smooth patterns. Irradiated ITO film showed a high transparency (∼85%) in the visible region. The electrical sheet resistance decrease with increasing time of exposure to UV light and UV laser. Only 5 min UV light irradiation is enough to decrease the electrical sheet resistance down to 5 kΩ□.

  11. Two Patterns of Adipokine and Other Biomarker Dynamics in a Long-Term Weight Loss Intervention

    Science.gov (United States)

    Blüher, Matthias; Rudich, Assaf; Klöting, Nora; Golan, Rachel; Henkin, Yaakov; Rubin, Eitan; Schwarzfuchs, Dan; Gepner, Yftach; Stampfer, Meir J.; Fiedler, Martin; Thiery, Joachim; Stumvoll, Michael; Shai, Iris

    2012-01-01

    OBJECTIVE Long-term dietary intervention frequently induces a rapid weight decline followed by weight stabilization/regain. Here, we sought to identify adipokine biomarkers that may reflect continued beneficial effects of dieting despite partial weight regain. RESEARCH DESIGN AND METHODS We analyzed the dynamics of fasting serum levels of 12 traditional metabolic biomarkers and novel adipokines among 322 participants in the 2-year Dietary Intervention Randomized Controlled Trial (DIRECT) of low-fat, Mediterranean, or low-carbohydrate diets for weight loss. RESULTS We identified two distinct patterns: Pattern A includes biomarkers (insulin, triglycerides, leptin, chemerin, monocyte chemoattractant protein 1, and retinol-binding protein 4) whose dynamics tightly correspond to changes in body weight, with the trend during the weight loss phase (months 0–6) going in the opposite direction to that in the weight maintenance/regain phase (months 7–24) (P weight adiponectin, HDL cholesterol [HDL-C], high-sensitivity C-reactive protein [hsCRP], fetuin-A, progranulin, and vaspin) that displayed a continued, cumulative improvement (P weight change and that the dynamic of hsCRP best typified pattern B. CONCLUSIONS hsCRP, HDL-C, adiponectin, fetuin-A, progranulin, and vaspin levels display a continued long-term improvement despite partial weight regain. This may likely reflect either a delayed effect of the initial weight loss or a continuous beneficial response to switching to healthier dietary patterns. PMID:22190676

  12. Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention.

    Science.gov (United States)

    Blüher, Matthias; Rudich, Assaf; Klöting, Nora; Golan, Rachel; Henkin, Yaakov; Rubin, Eitan; Schwarzfuchs, Dan; Gepner, Yftach; Stampfer, Meir J; Fiedler, Martin; Thiery, Joachim; Stumvoll, Michael; Shai, Iris

    2012-02-01

    Long-term dietary intervention frequently induces a rapid weight decline followed by weight stabilization/regain. Here, we sought to identify adipokine biomarkers that may reflect continued beneficial effects of dieting despite partial weight regain. We analyzed the dynamics of fasting serum levels of 12 traditional metabolic biomarkers and novel adipokines among 322 participants in the 2-year Dietary Intervention Randomized Controlled Trial (DIRECT) of low-fat, Mediterranean, or low-carbohydrate diets for weight loss. We identified two distinct patterns: Pattern A includes biomarkers (insulin, triglycerides, leptin, chemerin, monocyte chemoattractant protein 1, and retinol-binding protein 4) whose dynamics tightly correspond to changes in body weight, with the trend during the weight loss phase (months 0-6) going in the opposite direction to that in the weight maintenance/regain phase (months 7-24) (P weight adiponectin, HDL cholesterol [HDL-C], high-sensitivity C-reactive protein [hsCRP], fetuin-A, progranulin, and vaspin) that displayed a continued, cumulative improvement (P weight change and that the dynamic of hsCRP best typified pattern B. hsCRP, HDL-C, adiponectin, fetuin-A, progranulin, and vaspin levels display a continued long-term improvement despite partial weight regain. This may likely reflect either a delayed effect of the initial weight loss or a continuous beneficial response to switching to healthier dietary patterns.

  13. Fabrication of low-loss silicon-on-oxidized-porous-silicon strip waveguide using focused proton-beam irradiation.

    Science.gov (United States)

    Teo, E J; Bettiol, A A; Yang, P; Breese, M B H; Xiong, B Q; Mashanovich, G Z; Headley, W R; Reed, G T

    2009-03-01

    We have successfully fabricated low-loss silicon-on-oxidized-porous-silicon (SOPS) strip waveguides with high-index contrast using focused proton-beam irradiation and electrochemical etching. Smooth surface quality with rms roughness of 3.1 nm is achieved for a fluence of 1x10(15)/cm(2) after postoxidation treatment. Optical characterization at a wavelength of 1550 nm shows a loss of 1.1+/-0.4 dB/cm and 1.2+/-0.4 dB/cm in TE and TM polarization respectively, which we believe is the lowest reported loss for SOPS waveguides. This opens up new opportunities for all-silicon-based optoelectronics applications.

  14. [Control of Soil Nutrient Loss of Typical Reforestation Patterns Along the Three Gorges Reservoir Area].

    Science.gov (United States)

    Wu, Dong; Huang, Zhi-lin; Xiao, Wen-fa; Zeng, Li-xiong

    2015-10-01

    Annual soil nutrient loss characteristics on typical reforestation patterns in watershed along the Three Gorges Reservoir Area were studied based on runoff plot experiment. Runoff and sediment nutrition content from May to October 2014 of typical reforestation patterns including garden plot (tea garden), forest land (Chinese chestnut) and the original slope farmland were determined and then analyzed. The results showed that: (1) After the Returning Farmland to Forest Project the quantity of annual soil nutrient (nitrogen and phosphorus, the sum of them in sediment and runoff) loss decreased. The output of total nitrogen (TN) was in the order of slope farmland (2 444.27 g x hm(-2)) > tea garden (998.70 g x hm(-2)) > Chinese chestnut forest (532.61 g x hm(-2)), and for total phosphorus (TP) loss was slope farmland (1 690.48 g x hm(-2)) > tea garden (488.06 g x hm(-2)) > Chinese chestnut forest (129.00 g x hm(-2)) . Compared with slope farmland, the load of TN and TP output of reforestation patterns decreased 68.68% and 81.75%, respectively. (2) Compared with slope farmland, available nitrogen loss decreased in reforestation patterns. Total nitrate nitrogen (NO3(-)-N) loss ranked in the order of slope farmland (113.79 g x hm(-2)) > tea garden (73.75 g x hm(-2)) > Chinese chestnut forest (56.06 g x hm(-2)) The largest amount of ammonium nitrogen (NH4(+)-N) was found in tea garden (69.34 g x hm(-2)), then in farmland (52.45 g x hm(-2)), and the least in Chinese chestnut forest (47.23 g x hm(-2)). (3) The main route of NO3(-)-N and NH4(+)-N loss was both through runoff, the quantity of NO3(-)-N and NH4(+)-N output in which accounted for 91.4% and 92.2% of the total, respectively. The quantity of TN and TP in sediment accounted for 86.6% and 98.4% of the total. TN and TP loss showed an extremely significant correlation with sediments, which showed that sediment output was the main approach of TN and TP loss.

  15. A Novel Millimeter-Wave, Low-Loss, Electronically Controlled Phase Shifter for Monolithic, Beam-Steering Phased-Array Antenna Application

    National Research Council Canada - National Science Library

    Sarabandi, Kamal

    1997-01-01

    The purpose of this document is to summarize the accomplishments made on the project entitled "A Novel Millimeter-Wave, Low-Loss, Electronically Controlled Phase Shifter for Monolithic, Beam-Steering...

  16. Characterization of a wide dynamic-range, radiation-tolerant charge-digitizer asic for monitoring of Beam losses

    CERN Document Server

    Guido Venturini, G G; Dehning, B; Kayal, M

    2012-01-01

    An Application Specific Integrated Circuit (ASIC) has been designed and fabricated to provide a compact solution to digitize current signals from ionization chambers and diamond detectors, employed as beam loss monitors at CERN and several other high energy physics facilities. The circuit topology has been devised to accept positive and negative currents, to have a wide dynamic range (above 120 dB), withstand radiation levels over 10 Mrad and offer different modes of operation, covering a broad range of applications. Furthermore, an internal conversion reference is employed in the digitization, to provide an accurate absolute measurement. This paper discusses the detailed characterization of the first prototype: linearity, radiation tolerance and temperature dependence of the conversion, as well as implications and system-level considerations regarding its use for beam instrumentation applications in a high energy physics facility.

  17. Very Fast Losses of the Circulating LHC Beam, their Mitigation and Machine Protection

    OpenAIRE

    Baer, Tobias; Wenninger, Jorg; Elsen, Eckhard

    2013-01-01

    The Large Hadron Collider (LHC) has a nominal energy of 362MJ stored in each of its two counter-rotating beams - over two orders of magnitude more than any previous accelerator and enough to melt 880kg of copper. Therefore, in case of abnormal conditions comprehensive machine protection systems extract the beams safely from the LHC within not more than three turns $\\approx$270$\\mu$s. The first years of LHC operation demonstrated a remarkable reliability of the major machine protection systems...

  18. Doppler laser imaging predicts response to topical minoxidil in the treatment of female pattern hair loss.

    Science.gov (United States)

    McCoy, J; Kovacevic, M; Situm, M; Stanimirovic, A; Bolanca, Z; Goren, A

    2016-01-01

    Topical minoxidil is the only drug approved by the US FDA for the treatment of female pattern hair loss. Unfortunately, following 16 weeks of daily application, less than 40% of patients regrow hair. Several studies have demonstrated that sulfotransferase enzyme activity in plucked hair follicles predicts topical minoxidil response in female pattern hair loss patients. However, due to patients’ discomfort with the procedure, and the time required to perform the enzymatic assay it would be ideal to develop a rapid, non-invasive test for sulfotransferase enzyme activity. Minoxidil is a pro-drug converted to its active form, minoxidil sulfate, by sulfotransferase enzymes in the outer root sheath of hair. Minoxidil sulfate is the active form required for both the promotion of hair regrowth and the vasodilatory effects of minoxidil. We thus hypothesized that laser Doppler velocimetry measurement of scalp blood perfusion subsequent to the application of topical minoxidil would correlate with sulfotransferase enzyme activity in plucked hair follicles. In this study, plucked hair follicles from female pattern hair loss patients were analyzed for sulfotransferase enzyme activity. Additionally, laser Doppler velocimetry was used to measure the change in scalp perfusion at 15, 30, 45, and 60 minutes, after the application of minoxidil. In agreement with our hypothesis, we discovered a correlation (r=1.0) between the change in scalp perfusion within 60 minutes after topical minoxidil application and sulfotransferase enzyme activity in plucked hairs. To our knowledge, this is the first study demonstrating the feasibility of using laser Doppler imaging as a rapid, non-invasive diagnostic test to predict topical minoxidil response in the treatment of female pattern hair loss.

  19. Beam loss reduction by injection painting in the 3-GeV rapid cycling synchrotron of the Japan Proton Accelerator Research Complex

    Directory of Open Access Journals (Sweden)

    H. Hotchi

    2012-04-01

    Full Text Available The 3-GeV rapid cycling synchrotron (RCS of the Japan Proton Accelerator Research Complex was commissioned in October 2007. Via the initial beam tuning and a series of underlying beam studies with low-intensity beams, since December 2009, we have intermittently been performing beam tuning experiments with higher-intensity beams including the injection painting technique. By optimizing the injection painting parameters, we have successfully achieved a 420 kW-equivalent output intensity at a low-level intensity loss of less than 1%. Also the corresponding numerical simulation well reproduced the observed painting parameter dependence on the beam loss, and captured a characteristic behavior of the high-intensity beam in the injection painting process. In this paper, we present the experimental results obtained in the course of the RCS beam power ramp-up, especially on the beam loss reduction achieved by employing the injection painting, together with the numerical simulation results.

  20. 26 CFR 1.846-2T - Election by taxpayer to use its own historical loss payment pattern (temporary).

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Election by taxpayer to use its own historical loss payment pattern (temporary). 1.846-2T Section 1.846-2T Internal Revenue INTERNAL REVENUE SERVICE...-2T Election by taxpayer to use its own historical loss payment pattern (temporary). (a) through (c...

  1. Simulation of multicomponent losses in electron beam melting and refining at varying scan frequencies

    International Nuclear Information System (INIS)

    Powell, A.; Szekely, J.; Van Den Avyle, J.; Damkroger, B.

    1995-01-01

    A two-stage model is presented to describe alloy element evaporation rates from molten metal due to transient local heating by an electron beam. The first stage is a simulation of transient phenomena near the melt surface due to periodic heating by a scanning beam, the output of which is the relationship between operating parameters, surface temperature, and evaporation rate. At high scan rates, this can be done using a simple one-dimensional heat transfer model of the surface layer; at lower scan rates, a more complex three-dimensional model with fluid flow and periodic boundary conditions is necessary. The second stage couples this evaporation-surface temperature relationship with a larger steady state heat transfer and fluid flow model of an entire melting hearth or mold, in order to calculate local and total evaporation rates. Predictions are compared with experimental results from Sandia's 310-kW electron beam melting furnace, in which evaporation rates and vapor compositions were studied in pure titanium and Ti-6%Al-4%V alloy. Evaporation rates were estimated from rate of condensation on a substrate held over the hearth, and were characterized as a function of beam power (150 and 225 kW), scan frequency (30, 115 and 450 Hz) and background pressure (10 -3 , 10 -4 and 10 -5 torr)

  2. Severe signal loss in diamond beam loss monitors in high particle rate environments by charge trapping in radiation-induced defects

    Energy Technology Data Exchange (ETDEWEB)

    Kassel, Florian; Boer, Wim de [Institute for Experimental Nuclear Physics (IEKP), KIT, Karlsruhe (Germany); Guthoff, Moritz; Dabrowski, Anne [CERN, Meyrin (Switzerland)

    2016-10-15

    The beam condition monitoring leakage (BCML) system is a beam monitoring device in the compact muon solenoid (CMS) experiment at the large hadron collider (LHC). As detectors 32 poly-crystalline (pCVD) diamond sensors are positioned in rings around the beam pipe. Here, high particle rates occur from the colliding beams scattering particles outside the beam pipe. These particles cause defects, which act as traps for the ionization, thus reducing the charge collection efficiency (CCE). However, the loss in CCE was much more severe than expected from low rate laboratory measurements and simulations, especially in single-crystalline (sCVD) diamonds, which have a low initial concentration of defects. After an integrated luminosity of a few fb{sup -1} corresponding to a few weeks of LHC operation, the CCE of the sCVD diamonds dropped by a factor of five or more and quickly approached the poor CCE of pCVD diamonds. The reason why in real experiments the CCE is much worse than in laboratory experiments is related to the ionization rate. At high particle rates the trapping rate of the ionization is so high compared with the detrapping rate, that space charge builds up. This space charge reduces locally the internal electric field, which in turn increases the trapping rate and recombination and hence reduces the CCE in a strongly non-linear way. A diamond irradiation campaign was started to investigate the rate-dependent electrical field deformation with respect to the radiation damage. Besides the electrical field measurements via the transient current technique (TCT), the CCE was measured. The experimental results were used to create an effective deep trap model that takes the radiation damage into account. Using this trap model, the rate-dependent electrical field deformation and the CCE were simulated with the software SILVACO TCAD. The simulation, tuned to rate-dependent measurements from a strong radioactive source, was able to predict the non-linear decrease of the

  3. Severe signal loss in diamond beam loss monitors in high particle rate environments by charge trapping in radiation-induced defects

    International Nuclear Information System (INIS)

    Kassel, Florian; Boer, Wim de; Guthoff, Moritz; Dabrowski, Anne

    2016-01-01

    The beam condition monitoring leakage (BCML) system is a beam monitoring device in the compact muon solenoid (CMS) experiment at the large hadron collider (LHC). As detectors 32 poly-crystalline (pCVD) diamond sensors are positioned in rings around the beam pipe. Here, high particle rates occur from the colliding beams scattering particles outside the beam pipe. These particles cause defects, which act as traps for the ionization, thus reducing the charge collection efficiency (CCE). However, the loss in CCE was much more severe than expected from low rate laboratory measurements and simulations, especially in single-crystalline (sCVD) diamonds, which have a low initial concentration of defects. After an integrated luminosity of a few fb -1 corresponding to a few weeks of LHC operation, the CCE of the sCVD diamonds dropped by a factor of five or more and quickly approached the poor CCE of pCVD diamonds. The reason why in real experiments the CCE is much worse than in laboratory experiments is related to the ionization rate. At high particle rates the trapping rate of the ionization is so high compared with the detrapping rate, that space charge builds up. This space charge reduces locally the internal electric field, which in turn increases the trapping rate and recombination and hence reduces the CCE in a strongly non-linear way. A diamond irradiation campaign was started to investigate the rate-dependent electrical field deformation with respect to the radiation damage. Besides the electrical field measurements via the transient current technique (TCT), the CCE was measured. The experimental results were used to create an effective deep trap model that takes the radiation damage into account. Using this trap model, the rate-dependent electrical field deformation and the CCE were simulated with the software SILVACO TCAD. The simulation, tuned to rate-dependent measurements from a strong radioactive source, was able to predict the non-linear decrease of the CCE in

  4. Resolution Improvement and Pattern Generator Development for the Maskless Micro-Ion-Beam Reduction Lithography System

    International Nuclear Information System (INIS)

    Jiang, Ximan

    2006-01-01

    have been studied. The dependence of the throughput with the exposure field size and the speed of the mechanical stage has been investigated. In order to perform maskless lithography, different micro-fabricated pattern generators have been developed for the MMRL system. Ion beamlet switching has been successfully demonstrated on the MMRL system. A positive bias voltage around 10 volts is sufficient to switch off the ion current on the micro-fabricated pattern generators. Some unexpected problems, such as the high-energy secondary electron radiations, have been discovered during the experimental investigation. Thermal and structural analysis indicates that the aperture displacement error induced by thermal expansion can satisfy the 3(delta) CD requirement for lithography nodes down to 25 nm. The cross-talking effect near the surface and inside the apertures of the pattern generator has been simulated in a 3-D ray-tracing code. New pattern generator design has been proposed to reduce the cross-talking effect. In order to eliminate the surface charging effect caused by the secondary electrons, a new beam-switching scheme in which the switching electrodes are immersed in the plasma has been demonstrated on a mechanically fabricated pattern generator

  5. Conserving Biogeography: Habitat Loss and Vicariant Patterns in Endemic Squamates of the Cerrado Hotspot.

    Science.gov (United States)

    de Mello, Pietro L H; Machado, Ricardo B; Nogueira, Cristiano de C

    2015-01-01

    Little is known about the threat levels and impacts of habitat loss over the Cerrado Squamate fauna. The region is under severe habitat loss due to mechanized agriculture, accelerated by changes in the Brazilian National Forest Code. The Squamate fauna of the Cerrado is rich in endemics and is intrinsically associated with its surrounding microhabitats, which make up a mosaic of phitophysiognomies throughout the region. Herein we evaluate current conservation status of Squamate biogeographic patterns in the Brazilian Cerrado, the single savanna among global biodiversity hotspots. To do so, we first updated point locality data on 49 endemic Squamates pertaining to seven non-random clusters of species ranges in the Cerrado. Each cluster was assumed to be representative of different biogeographic regions, holding its own set of species, herein mapped according to their extent of occurrence (EOO). We then contrasted these data in four different scenarios, according to the presence or absence of habitat loss and the presence or absence of the current protected area (PA) cover. We searched for non-random patterns of habitat loss and PA coverage among these biogeographic regions throughout the Cerrado. Finally, with the species EOO as biodiversity layers, we used Zonation to discuss contemporary PA distribution, as well as to highlight current priority areas for conservation within the Cerrado. We ran Zonation under all four conservation scenarios mentioned above. We observed that habitat loss and PA coverage significantly differed between biogeographic regions. The southernmost biogeographic region is the least protected and the most impacted, with priority areas highly scattered in small, disjunct fragments. The northernmost biogeographic region (Tocantins-Serra Geral) is the most protected and least impacted, showing extensive priority areas in all Zonation scenarios. Therefore, current and past deforestation trends are severely threatening biogeographic patterns in

  6. PATTERNS OF HEARING LOSS IN ELDERLY MALES- DATA FROM A TERTIARY CARE CLINIC IN INDIA

    Directory of Open Access Journals (Sweden)

    Ranjana Kumari

    2016-11-01

    Full Text Available BACKGROUND Hearing impairment is present in at least one-third of the population above 65 years of age. This loss of hearing leads to difficulty in social or professional interactions, social isolation depression individually. Besides in the working population above, it results in loss of efficiency and financial burden. This study has been undertaken to study the pattern of hearing in the above 50 years males who attended the E.N.T. OP in our tertiary care hospital for various ear-related complaints. MATERIALS AND METHODS This cross-sectional study was carried out in the E.N.T. Department, Government Mohan Kumaramangalam Medical College between 6th August 2012 and 30 th May 2015. 486 male patients with complaints related to ear were included. Those patients who had otitis media or had undergone ear surgery were excluded. RESULTS Hearing impairment was detected in 62% of the study population, although only 10% reported to the clinic due to complaints of hearing loss by family. Noise-induced hearing loss was detected in 27.5% of the patients. CONCLUSION Routine audiological evaluation especially in adults in the over 50 age group should be a priority. There should be more emphasis on adopting strategies to prevent noise-induced hearing loss and on rehabilitating the above 50 hearing impaired in our society.

  7. Dietary patterns in weight loss maintenance: results from the MedWeight study.

    Science.gov (United States)

    Karfopoulou, Eleni; Brikou, Dora; Mamalaki, Eirini; Bersimis, Fragiskos; Anastasiou, Costas A; Hill, James O; Yannakoulia, Mary

    2017-04-01

    The dietary habits contributing to weight loss maintenance are not sufficiently understood. We studied weight loss maintainers in comparison with regainers, to identify the differentiating behaviors. The MedWeight study is a Greek registry of weight loss maintainers and regainers. Participants had intentionally lost ≥10 % of their weight and either had maintained this loss for over a year, or had regained weight. Questionnaires on demographics and lifestyle habits were completed online. Dietary assessment was carried out by two telephone 24-h recalls. Present analysis focused on 361 participants (32 years old, 39 % men): 264 maintainers and 97 regainers. Energy and macronutrient intake did not differ by maintenance status (1770 ± 651 kcal in maintainers vs. 1845 ± 678 kcal in regainers, p = 0.338), although protein intake per kg of body weight was higher in maintainers (1.02 ± 0.39 vs. 0.83 ± 0.28 g/kg in regainers, p meal preparation and eating at home for men, and a higher eating frequency and slower eating rate for women. Men maintaining weight loss were much more likely to adhere to a healthy eating pattern. Eating at home, involvement in meal preparation, higher eating frequency and slower eating rate were also associated with maintenance. These lifestyle habits of successful maintainers provide target behaviors to improve obesity treatment.

  8. SKA aperture array verification system: electromagnetic modeling and beam pattern measurements using a micro UAV

    Science.gov (United States)

    de Lera Acedo, E.; Bolli, P.; Paonessa, F.; Virone, G.; Colin-Beltran, E.; Razavi-Ghods, N.; Aicardi, I.; Lingua, A.; Maschio, P.; Monari, J.; Naldi, G.; Piras, M.; Pupillo, G.

    2017-12-01

    In this paper we present the electromagnetic modeling and beam pattern measurements of a 16-elements ultra wideband sparse random test array for the low frequency instrument of the Square Kilometer Array telescope. We discuss the importance of a small array test platform for the development of technologies and techniques towards the final telescope, highlighting the most relevant aspects of its design. We also describe the electromagnetic simulations and modeling work as well as the embedded-element and array pattern measurements using an Unmanned Aerial Vehicle system. The latter are helpful both for the validation of the models and the design as well as for the future instrumental calibration of the telescope thanks to the stable, accurate and strong radio frequency signal transmitted by the UAV. At this stage of the design, these measurements have shown a general agreement between experimental results and numerical data and have revealed the localized effect of un-calibrated cable lengths in the inner side-lobes of the array pattern.

  9. SKA aperture array verification system: electromagnetic modeling and beam pattern measurements using a micro UAV

    Science.gov (United States)

    de Lera Acedo, E.; Bolli, P.; Paonessa, F.; Virone, G.; Colin-Beltran, E.; Razavi-Ghods, N.; Aicardi, I.; Lingua, A.; Maschio, P.; Monari, J.; Naldi, G.; Piras, M.; Pupillo, G.

    2018-03-01

    In this paper we present the electromagnetic modeling and beam pattern measurements of a 16-elements ultra wideband sparse random test array for the low frequency instrument of the Square Kilometer Array telescope. We discuss the importance of a small array test platform for the development of technologies and techniques towards the final telescope, highlighting the most relevant aspects of its design. We also describe the electromagnetic simulations and modeling work as well as the embedded-element and array pattern measurements using an Unmanned Aerial Vehicle system. The latter are helpful both for the validation of the models and the design as well as for the future instrumental calibration of the telescope thanks to the stable, accurate and strong radio frequency signal transmitted by the UAV. At this stage of the design, these measurements have shown a general agreement between experimental results and numerical data and have revealed the localized effect of un-calibrated cable lengths in the inner side-lobes of the array pattern.

  10. Mechanism of surface morphology in electron beam melting of Ti6Al4V based on computational flow patterns

    Science.gov (United States)

    Ge, Wenjun; Han, Sangwoo; Fang, Yuchao; Cheon, Jason; Na, Suck Joo

    2017-10-01

    In this study, a 3D numerical model was proposed that uses the computational fluid dynamics (CFD) method to investigate molten pool formation in electron beam melting under different process parameters. Electron beam ray tracking was used to determine energy deposition in the powder bed model. The melt tracks obtained in this study can be divided into three categories: a balling pattern, distortion pattern and straight pattern. The 3D mesoscale model revealed that it is possible to obtain different molten pool temperature distributions, flow patterns and top surface morphologies using different process parameters. Detailed analysis was performed on the formation mechanism of both the balling defect and distortion pattern. The simulation results of the top surface morphology were also compared with experimental results and showed good agreement.

  11. THE HYDROGEN EPOCH OF REIONIZATION ARRAY DISH. I. BEAM PATTERN MEASUREMENTS AND SCIENCE IMPLICATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Neben, Abraham R.; Hewitt, Jacqueline N.; Ewall-Wice, Aaron [MIT Kavli Institute, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Bradley, Richard F. [Department of Electrical and Computer Engineering, University of Virginia, Charlottesville, VA 22904 (United States); DeBoer, David R.; Parsons, Aaron R.; Ali, Zaki S.; Cheng, Carina; Patra, Nipanjana; Dillon, Joshua S. [Department of Astronomy, University of California, Berkeley, CA (United States); Aguirre, James E.; Kohn, Saul A. [Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA (United States); Thyagarajan, Nithyanandan; Bowman, Judd; Jacobs, Daniel C. [Arizona State University, School of Earth and Space Exploration, Tempe, AZ 85287 (United States); Dickenson, Roger; Doolittle, Phillip; Egan, Dennis; Hedrick, Mike; Klima, Patricia J. [National Radio Astronomy Observatory, Charlottesville, VA (United States); and others

    2016-08-01

    The Hydrogen Epoch of Reionization Array (HERA) is a radio interferometer aiming to detect the power spectrum of 21 cm fluctuations from neutral hydrogen from the epoch of reionization (EOR). Drawing on lessons from the Murchison Widefield Array and the Precision Array for Probing the EOR, HERA is a hexagonal array of large (14 m diameter) dishes with suspended dipole feeds. The dish not only determines overall sensitivity, but also affects the observed frequency structure of foregrounds in the interferometer. This is the first of a series of four papers characterizing the frequency and angular response of the dish with simulations and measurements. In this paper, we focus on the angular response (i.e., power pattern), which sets the relative weighting between sky regions of high and low delay and thus apparent source frequency structure. We measure the angular response at 137 MHz using the ORBCOMM beam mapping system of Neben et al. We measure a collecting area of 93 m{sup 2} in the optimal dish/feed configuration, implying that HERA-320 should detect the EOR power spectrum at z ∼ 9 with a signal-to-noise ratio of 12.7 using a foreground avoidance approach with a single season of observations and 74.3 using a foreground subtraction approach. Finally, we study the impact of these beam measurements on the distribution of foregrounds in Fourier space.

  12. Exploration of the ultimate patterning potential achievable with focused ion beams

    International Nuclear Information System (INIS)

    Gierak, J.; Bourhis, E.; Faini, G.; Patriarche, G.; Madouri, A.; Jede, R.; Bruchhaus, L.; Bauerdick, S.; Schiedt, B.; Biance, A.L.; Auvray, L.

    2009-01-01

    Decisive advances in the field of nanosciences and nanotechnologies are intimately related to the development of new instruments and of related writing schemes and methodologies. Therefore we have recently proposed the exploitation of the nano-structuring potential of a highly focused ion beam (FIB) as a tool, to overcome intrinsic limitations of current nano-fabrication techniques and to allow innovative patterning schemes that are urgently needed in many nanoscience challenges. In this work, we will first detail a very high-resolution FIB instrument we have developed specifically to meet these nano-fabrication requirements. Then we will introduce and illustrate an advanced FIB processing scheme that is the fabrication of artificial nanopores.

  13. Development and characterization of micro-pattern gas detectors for intense beams of hadrons

    International Nuclear Information System (INIS)

    Vandenbroucke, Maxence

    2012-01-01

    This thesis work is dedicated to the design, development and characterization of Micro-Pattern Gas Detectors. The performances of a Time Projection Chamber (TPC) equipped with a triple Gas Electron Multiplier (GEM) amplification structure are reported. The intrinsic ion backflow suppression of GEM foils drastically reduces the space charge produced by wire readout in traditional TPC. The GEM solution allows the operation of a TPC at much higher event rate. The second part of this thesis describes the development of a 40 x 40 cm 2 Micromegas detector with a highly segmented central area. A reduction of discharges compared to conventional Micromegas detectors is needed for stable operation in intense beams of hadrons. Spark reduction technologies have been successfully studied and results are presented.

  14. Polarized Uniform Linear Array System: Beam Radiation Pattern, Beamforming Diversity Order, and Channel Capacity

    Directory of Open Access Journals (Sweden)

    Xin Su

    2015-01-01

    Full Text Available There have been many studies regarding antenna polarization; however, there have been few publications on the analysis of the channel capacity for polarized antenna systems using the beamforming technique. According to Chung et al., the channel capacity is determined by the density of scatterers and the transmission power, which is obtained based on the assumption that scatterers are uniformly distributed on a 3D spherical scattering model. However, it contradicts the practical scenario, where scatterers may not be uniformly distributed under outdoor environment, and lacks the consideration of fading channel gain. In this study, we derive the channel capacity of polarized uniform linear array (PULA systems using the beamforming technique in a practical scattering environment. The results show that, for PULA systems, the channel capacity, which is boosted by beamforming diversity, can be determined using the channel gain, beam radiation pattern, and beamforming diversity order (BDO, where the BDO is dependent on the antenna characteristics and array configurations.

  15. Development and characterization of micro-pattern gas detectors for intense beams of hadrons

    Energy Technology Data Exchange (ETDEWEB)

    Vandenbroucke, Maxence

    2012-07-02

    This thesis work is dedicated to the design, development and characterization of Micro-Pattern Gas Detectors. The performances of a Time Projection Chamber (TPC) equipped with a triple Gas Electron Multiplier (GEM) amplification structure are reported. The intrinsic ion backflow suppression of GEM foils drastically reduces the space charge produced by wire readout in traditional TPC. The GEM solution allows the operation of a TPC at much higher event rate. The second part of this thesis describes the development of a 40 x 40 cm{sup 2} Micromegas detector with a highly segmented central area. A reduction of discharges compared to conventional Micromegas detectors is needed for stable operation in intense beams of hadrons. Spark reduction technologies have been successfully studied and results are presented.

  16. Patterns of loss and regeneration of tropical dry forest in Madagascar: the social institutional context.

    Science.gov (United States)

    Elmqvist, Thomas; Pyykönen, Markku; Tengö, Maria; Rakotondrasoa, Fanambinantsoa; Rabakonandrianina, Elisabeth; Radimilahy, Chantal

    2007-05-02

    Loss of tropical forests and changes in land-use/land-cover are of growing concern worldwide. Although knowledge exists about the institutional context in which tropical forest loss is embedded, little is known about the role of social institutions in influencing regeneration of tropical forests. In the present study we used Landsat images from southern Madagascar from three different years (1984, 1993 and 2000) and covering 5500 km(2), and made a time-series analysis of three distinct large-scale patterns: 1) loss of forest cover, 2) increased forest cover, and 3) stable forest cover. Institutional characteristics underlying these three patterns were analyzed, testing the hypothesis that forest cover change is a function of strength and enforcement of local social institutions. The results showed a minor decrease of 7% total forest cover in the study area during the whole period 1984-2000, but an overall net increase of 4% during the period 1993-2000. The highest loss of forest cover occurred in a low human population density area with long distances to markets, while a stable forest cover occurred in the area with highest population density and good market access. Analyses of institutions revealed that loss of forest cover occurred mainly in areas characterized by insecure property rights, while areas with well-defined property rights showed either regenerating or stable forest cover. The results thus corroborate our hypothesis. The large-scale spontaneous regeneration dominated by native endemic species appears to be a result of a combination of changes in precipitation, migration and decreased human population and livestock grazing pressure, but under conditions of maintained and well-defined property rights. Our study emphasizes the large capacity of a semi-arid system to spontaneously regenerate, triggered by decreased pressures, but where existing social institutions mitigate other drivers of deforestation and alternative land-use.

  17. Patterns of loss and regeneration of tropical dry forest in Madagascar: the social institutional context.

    Directory of Open Access Journals (Sweden)

    Thomas Elmqvist

    Full Text Available Loss of tropical forests and changes in land-use/land-cover are of growing concern worldwide. Although knowledge exists about the institutional context in which tropical forest loss is embedded, little is known about the role of social institutions in influencing regeneration of tropical forests. In the present study we used Landsat images from southern Madagascar from three different years (1984, 1993 and 2000 and covering 5500 km(2, and made a time-series analysis of three distinct large-scale patterns: 1 loss of forest cover, 2 increased forest cover, and 3 stable forest cover. Institutional characteristics underlying these three patterns were analyzed, testing the hypothesis that forest cover change is a function of strength and enforcement of local social institutions. The results showed a minor decrease of 7% total forest cover in the study area during the whole period 1984-2000, but an overall net increase of 4% during the period 1993-2000. The highest loss of forest cover occurred in a low human population density area with long distances to markets, while a stable forest cover occurred in the area with highest population density and good market access. Analyses of institutions revealed that loss of forest cover occurred mainly in areas characterized by insecure property rights, while areas with well-defined property rights showed either regenerating or stable forest cover. The results thus corroborate our hypothesis. The large-scale spontaneous regeneration dominated by native endemic species appears to be a result of a combination of changes in precipitation, migration and decreased human population and livestock grazing pressure, but under conditions of maintained and well-defined property rights. Our study emphasizes the large capacity of a semi-arid system to spontaneously regenerate, triggered by decreased pressures, but where existing social institutions mitigate other drivers of deforestation and alternative land-use.

  18. Challenges of arbitrary waveform signal detection by Silicon Photomultipliers as readout for Cherenkov fibre based beam loss monitoring systems

    CERN Document Server

    Vinogradov, Sergey; Nebot del Busto, Eduardo; Kastriotou, Maria; Welsch, Carsten P

    2016-01-01

    Silicon Photomultipliers (SiPMs) are well recognised as very competitive photodetectors due to their exceptional photon number and time resolution, room-temperature low-voltage operation, insensitivity to magnetic fields, compactness, and robustness. Detection of weak light pulses of nanosecond time scale appears to be the best area for SiPM applications because in this case most of the SiPM drawbacks have a rather limited effect on its performance. In contrast to the more typical scintillation and Cherenkov detection applications, which demand information on the number of photons and/or the arrival time of the light pulse only, beam loss monitoring (BLM) systems utilising Cherenkov fibres with photodetector readout have to precisely reconstruct the temporal profile of the light pulse. This is a rather challenging task for any photon detector especially taking into account the high dynamic range of incident signals (100K – 1M) from a few photons to a few percents of destructive losses in a beam line and pre...

  19. A Bench Measurement of the Energy Loss of a Stored Beam to a Cavity

    Energy Technology Data Exchange (ETDEWEB)

    Sands, M; Rees, J.; /SLAC

    2016-12-19

    A rather simple electronic bench experiment is proposed for obtaining a measure of the impulse energy loss of a stored particle bunch to an rf cavity or other vacuum-chamber structure--the so-called "cavity radiation". The proposed method is analyzed in some detail.

  20. The Effects of More Extreme Rainfall Patterns on Infiltration and Nutrient Losses in Agricultural Soils

    Science.gov (United States)

    Hess, L.; Basso, B.; Hinckley, E. L. S.; Robertson, G. P.; Matson, P. A.

    2015-12-01

    In the coming century, the proportion of total rainfall that falls in heavy storm events is expected to increase in many areas, especially in the US Midwest, a major agricultural region. These changes in rainfall patterns may have consequences for hydrologic flow and nutrient losses, especially in agricultural soils, with potentially negative consequences for receiving ground- and surface waters. We used a tracer experiment to examine how more extreme rainfall patterns may affect the movement of water and solutes through an agricultural soil profile in the upper Midwest, and to what extent tillage may moderate these effects. Two rainfall patterns were created with 5m x 5m rainout shelters at the Kellogg Biological Station LTER site in replicated plots with either conventional tillage or no-till management. Control rainfall treatments received water 3x per week, and extreme rainfall treatments received the same total amount of water but once every two weeks, to simulate less frequent but larger storms. In April 2015, potassium bromide (KBr) was added as a conservative tracer of water flow to all plots, and Br- concentrations in soil water at 1.2m depth were measured weekly from April through July. Soil water Br- concentrations increased and peaked more quickly under the extreme rainfall treatment, suggesting increased infiltration and solute transfer to depth compared to soils exposed to control rainfall patterns. Soil water Br- also increased and peaked more quickly in no-till than in conventional tillage treatments, indicating differences in flow paths between management systems. Soil moisture measured every 15 minutes at 10, 40, and 100cm depths corroborates tracer experiment results: rainfall events simulated in extreme rainfall treatments led to large increases in deep soil moisture, while the smaller rainfall events simulated under control conditions did not. Deep soil moisture in no-till treatments also increased sooner after water application as compared to

  1. Effects of focused ion beam milling on electron backscatter diffraction patterns in strontium titanate and stabilized zirconia

    DEFF Research Database (Denmark)

    Saowadee, Nath; Agersted, Karsten; Bowen, Jacob R.

    2012-01-01

    This study investigates the effect of focused ion beam (FIB) current and accelerating voltage on electron backscatter diffraction pattern quality of yttria‐stabilized zirconia (YSZ) and Nb‐doped strontium titanate (STN) to optimize data quality and acquisition time for 3D‐EBSD experiments by FIB...

  2. Investigation of Electron Beam Induced Mass Loss of Embedding Media in the Low Voltage STEM

    Czech Academy of Sciences Publication Activity Database

    Novotná, V.; Hrubanová, Kamila; Nebesářová, J.; Krzyžánek, Vladislav

    2014-01-01

    Roč. 20, S3 (2014), s. 1270-1271 ISSN 1431-9276 R&D Projects: GA MŠk EE.2.3.20.0103; GA MŠk(CZ) LO1212; GA ČR(CZ) GA14-20012S; GA TA ČR TE01020118 Institutional support: RVO:68081731 Keywords : mass loss * mass-thickness measurement * low voltage STEM Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 1.877, year: 2014

  3. Retrograde amnesia produced by electron beam exposure: casual parameters and duration of memory loss. Final report for November 84

    Energy Technology Data Exchange (ETDEWEB)

    Wheeler, T.G.; Hardy, K.A.

    1985-01-01

    The production of retrograde amnesia (RA) upon electron-beam exposure was investigated. RA production was evaluated using a single-trial avoidance task for 10, 1, and 0.1 microsecond pulsed exposures. The dose-response curve obtained at each pulse duration showed significant RA production. The most effective dose range was 0.1-10 rad at a dose rate of 1,000,000 rad/sec. By employing a 10 rad (1,000,000 rad/s) pulse, a memory loss of the events occurring in the previous 4 sec was demonstrated. The conclusion was that the RA effect might be due to sensory system activation which provided a novel stimulus that masked previous stimuli.

  4. Spatial and temporal patterns of pesticide losses in a small Swedish agricultural catchment

    Science.gov (United States)

    Sandin, Maria; Piikki, Kristin; Jarvis, Nicholas; Larsbo, Mats; Bishop, Kevin; Kreuger, Jenny

    2017-04-01

    sandy sub-catchment. This suggests that transport of pesticides to the stream is almost entirely occurring along fast flow paths such as macropore flow to drains or surface runoff. Only a very small proportion of fields are directly connected to the stream by overland pathways, which suggests that macropore flow to drains was the dominant loss pathway in the studied area. Data on pesticide use patterns revealed that compounds were detected in drainage and stream water samples that had not been applied for several years. This suggests that despite the predominant role of fast flow paths in determining losses to the stream, long-term storage along the transport pathways also occurs, presumably in subsoil where degradation is slow.

  5. Beam backgrounds in the ATLAS detector during LHC loss map tests at beta*=40cm and beta*=80cm at Ebeam=6.5 TeV

    CERN Document Server

    The ATLAS collaboration

    2017-01-01

    In this note the beam-background measurements with the ATLAS detector during lossmap tests of the LHC are described. Loss maps taken at beta*=40 cm and the normal 2015 setting of beta*=80 cm are compared. In the first case several collimator settings were explored, resulting in significant changes of beam backgrounds in ATLAS. Besides the studies of the dependence of background on collimation, which are important for optimisation of the LHC performance, these tests provide a clean environment to study the relative importance of beam halo losses on the experiment. The results show that the halo-related component of beam background in ATLAS decreases exponentially with increasing aperture of the tertiary collimators, the slope in terms of nominal sigma being about -0.5. From the data it is also shown that in normal operation conditions of LHC run 2 the beam halo losses contribute at most at the percent level to the total background, the dominant part coming from beam-gas interactions. The data are also used to ...

  6. Fabrication of Si surface pattern by Ar beam irradiation and annealing method

    International Nuclear Information System (INIS)

    Zhang, J.; Momota, S.; Maeda, K.; Terauchi, H.; Furuta, M.; Kawaharamura, T.; Nitta, N.; Wang, D.

    2012-01-01

    The fabrication process of crater structures on Si crystal has been studied by an irradiation of Ar beam and a thermal annealing at 600 °C. The fabricated surface was measured by field emission scanning electron microscope and atomic force microscope. The results have shown the controllability of specifications of crater formation such as density, diameter and depth by changing two irradiation parameters, fluence and energy of Ar ions. By changing the fluence over a range of 1 ∼ 10 × 10 16 /cm 2 , we could control a density of crater 0 ∼ 39 counts/100μm 2 . By changing the energy over a range of 90 ∼ 270 keV, we could control a diameter and a depth of crater in 0.8 ∼ 4.1μm and 99 ∼ 229nm, respectively. The present result is consistent with the previously proposed model that the crater structure would be arising from an exfoliated surface layer of silicon. The present result has indicated the possibility of the crater production phenomena as a hopeful method to fabricate the surface pattern on a micro-nano meter scale.

  7. Electron beam patterning for writing of positively charged gold colloidal nanoparticles

    Science.gov (United States)

    Zafri, Hadar; Azougi, Jonathan; Girshevitz, Olga; Zalevsky, Zeev; Zitoun, David

    2018-02-01

    Synthesis at the nanoscale has progressed at a very fast pace during the last decades. The main challenge today lies in precise localization to achieve efficient nanofabrication of devices. In the present work, we report on a novel method for the patterning of gold metallic nanoparticles into nanostructures on a silicon-on-insulator (SOI) wafer. The fabrication makes use of relatively accessible equipment, a scanning electron microscope (SEM), and wet chemical synthesis. The electron beam implants electrons into the insulating material, which further anchors the positively charged Au nanoparticles by electrostatic attraction. The novel fabrication method was applied to several substrates useful in microelectronics to add plasmonic particles. The resolution and surface density of the deposition were tuned, respectively, by the electron energy (acceleration voltage) and the dose of electronic irradiation. We easily achieved the smallest written feature of 68 ± 18 nm on SOI, and the technique can be extended to any positively charged nanoparticles, while the resolution is in principle limited by the particle size distribution and the scattering of the electrons in the substrate. [Figure not available: see fulltext.

  8. Monte Carlo simulations to estimate the damage potential of electron beam and tests of beam loss detector based on quartz Cherenkov radiator read out by a silicon photomultiplier on CLIC Test Facility 3(CTF3)

    CERN Document Server

    Orfanelli, Styliani; Gazis, E

    The Compact Linear Collider (CLIC) study is a feasibility study aiming at the development of an electron/positron linear collider with a centre of mass energy in the multi-TeV energy range. Each Linac will have a length of 21 km, which means that very high accelerating gradients (>100 MV/m) are required. To achieve the high accelerating gradients, a novel two-beam acceleration scheme, in which RF power is transferred from a high-current, low-energy drive beam to the low-current, high energy main accelerating beam is designed. A Beam Loss Monitoring (BLM) system will be designed for CLIC to meet the requirements of the accelerator complex. Its main role as part of the machine protection scheme will be to detect potentially dangerous beam instabilities and prevent subsequent injection into the main beam or drive beam decelerators. The first part of this work describes the GEANT4 Monte Carlo simulations performed to estimate the damage potential of high energy electron beams impacting a copper target. The second...

  9. Quantifying spatial habitat loss from hydrocarbon development through assessing habitat selection patterns of mule deer.

    Science.gov (United States)

    Northrup, Joseph M; Anderson, Charles R; Wittemyer, George

    2015-11-01

    Extraction of oil and natural gas (hydrocarbons) from shale is increasing rapidly in North America, with documented impacts to native species and ecosystems. With shale oil and gas resources on nearly every continent, this development is set to become a major driver of global land-use change. It is increasingly critical to quantify spatial habitat loss driven by this development to implement effective mitigation strategies and develop habitat offsets. Habitat selection is a fundamental ecological process, influencing both individual fitness and population-level distribution on the landscape. Examinations of habitat selection provide a natural means for understanding spatial impacts. We examined the impact of natural gas development on habitat selection patterns of mule deer on their winter range in Colorado. We fit resource selection functions in a Bayesian hierarchical framework, with habitat availability defined using a movement-based modeling approach. Energy development drove considerable alterations to deer habitat selection patterns, with the most substantial impacts manifested as avoidance of well pads with active drilling to a distance of at least 800 m. Deer displayed more nuanced responses to other infrastructure, avoiding pads with active production and roads to a greater degree during the day than night. In aggregate, these responses equate to alteration of behavior by human development in over 50% of the critical winter range in our study area during the day and over 25% at night. Compared to other regions, the topographic and vegetative diversity in the study area appear to provide refugia that allow deer to behaviorally mediate some of the impacts of development. This study, and the methods we employed, provides a template for quantifying spatial take by industrial activities in natural areas and the results offer guidance for policy makers, mangers, and industry when attempting to mitigate habitat loss due to energy development. © 2015 The Authors

  10. Patterns of CDKN2A gene loss in sequential oral epithelial dysplasias and carcinomas.

    Science.gov (United States)

    Shahnavaz, S A; Bradley, G; Regezi, J A; Thakker, N; Gao, L; Hogg, D; Jordan, R C

    2001-03-15

    The CDKN2A gene locus encodes two different proteins derived from alternative splicing. p16 (exons 1alpha, 2, and 3) acts as a G1 cell cycle regulator, and p14ARF (exons 1beta, 2, and 3) acts to modulate MDM2-mediated degradation of p53. Inactivation of p16 is a common finding in many cancers; however, there is little data on CDKN2A gene abnormalities in oral precancer. In this longitudinal study, we examined changes in the CDKN2A gene locus in sequential epithelial dysplasias and oral carcinomas from 11 patients. Genomic DNA was extracted from laser-microdissected lesional tissue, and exons 1alpha, 1beta, and 2 were analyzed by duplex PCR. Immunohistochemistry was done to identify p16 and p14ARF protein expression. Two adjacent polymorphic microsatellite markers were used for allelotyping. Homozygous deletion of exon 1alpha was identified in 2 of 17 (12%) precancerous lesions. Loss of either exon 1alpha, exon 2, or both was seen in seven of nine (78%) carcinomas. In five of these carcinomas, there was loss of only exon 1alpha. No case showed deletion of exon 1beta. In 5 of 11 patients, microsatellite markers showed differing patterns of allelic imbalance in the precancerous lesions and the subsequent carcinoma, suggesting a complex genetic pattern of progression from dysplasia to carcinoma. We conclude that during oral carcinogenesis homozygous deletion of exon 1alpha of the CDKN2A gene is common but that deletion of exon 2 and 1beta is less frequent. Moreover, our results suggest that the progression from oral precancer to cancer, in some cases, is more complex genetically than predicted by linear models of carcinogenesis.

  11. Effects of tissue inhomogeneities on dose patterns in cylinders irradiated by negative pion beams

    International Nuclear Information System (INIS)

    Hamm, R.N.; Wright, H.A.; Turner, J.E.

    1975-10-01

    Effects of the presence of inhomogeneities in tissue irradiated by negative pion beams are investigated. Soft-tissue targets are considered with embedded regions of bone and cavities of air. The absorbed dose is calculated as a function of position in the targets for parallel and converging beams and for two parallel beams that enter the target from opposite sides. Isodose contours are calculated and displayed in each case. While these studies show expected trends, they indicate that specific calculations are needed for other beam parameters and target geometries. The contributions of neutrons to the dose contours can be seen from several calculations made both with and without neutrons

  12. Optic nerve histopathology in a case of Wolfram Syndrome: a mitochondrial pattern of axonal loss.

    Science.gov (United States)

    Ross-Cisneros, Fred N; Pan, Billy X; Silva, Ruwan A; Miller, Neil R; Albini, Thomas A; Tranebjaerg, Lisbeth; Rendtorff, Nanna D; Lodahl, Marianne; Moraes-Filho, Milton N; Moraes, Milton N; Salomao, Solange R; Berezovsky, Adriana; Belfort, Rubens; Carelli, Valerio; Sadun, Alfredo A

    2013-11-01

    Mitochondrial dysfunction in Wolfram Syndrome (WS) is controversial and optic neuropathy, a cardinal clinical manifestation, is poorly characterized. We here describe the histopathological features in postmortem retinas and optic nerves (ONs) from one patient with WS, testing the hypothesis that mitochondrial dysfunction underlies the pathology. Eyes and retrobulbar ONs were obtained at autopsy from a WS patient, and compared with those of a Leber hereditary optic neuropathy (LHON) patient and one healthy control. Retinas were stained with hematoxylin & eosin for general morphology and ONs were immunostained for myelin basic protein (MBP). Immunostained ONs were examined in four "quadrants": superior, inferior, nasal, and temporal. The WS retinas displayed a severe loss of retinal ganglion cells in the macular region similar to the LHON retina, but not in the control. The WS ONs, immunostained for MBP, revealed a zone of degeneration in the temporal and inferior quadrants. This pattern was similar to that seen in the LHON ONs but not in the control. Thus, the WS patient displayed a distinct pattern of optic atrophy observed bilaterally in the temporal and inferior quadrants of the ONs. This arrangement of axonal degeneration, involving primarily the papillomacular bundle, closely resembled LHON and other mitochondrial optic neuropathies, supporting that mitochondrial dysfunction underlies its pathogenesis. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. Moment method analysis of linearly tapered slot antennas: Low loss components for switched beam radiometers

    Science.gov (United States)

    Koeksal, Adnan; Trew, Robert J.; Kauffman, J. Frank

    1992-01-01

    A Moment Method Model for the radiation pattern characterization of single Linearly Tapered Slot Antennas (LTSA) in air or on a dielectric substrate is developed. This characterization consists of: (1) finding the radiated far-fields of the antenna; (2) determining the E-Plane and H-Plane beamwidths and sidelobe levels; and (3) determining the D-Plane beamwidth and cross polarization levels, as antenna parameters length, height, taper angle, substrate thickness, and the relative substrate permittivity vary. The LTSA geometry does not lend itself to analytical solution with the given parameter ranges. Therefore, a computer modeling scheme and a code are necessary to analyze the problem. This necessity imposes some further objectives or requirements on the solution method (modeling) and tool (computer code). These may be listed as follows: (1) a good approximation to the real antenna geometry; and (2) feasible computer storage and time requirements. According to these requirements, the work is concentrated on the development of efficient modeling schemes for these type of problems and on reducing the central processing unit (CPU) time required from the computer code. A Method of Moments (MoM) code is developed for the analysis of LTSA's within the parameter ranges given.

  14. Conoscopic patterns and quadrefringence of a singular beam in a uniaxial crystal

    Science.gov (United States)

    Fadeyeva, T.; Rubass, A.; Kotlyarov, K.; Volyar, A.; Swartzlander, G., Jr.

    2008-05-01

    The splitting of a fundamental vortex beam into four separate beams is theoretically and experimentally described for the propagation of light through a uniaxial crystal. This novel phenomenon opens new opportunities for higher order the entanglement of and correlation of photons.

  15. Direct periodic patterning of GaN-based light-emitting diodes by three-beam interference laser ablation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeomoh; Ji, Mi-Hee; Detchprohm, Theeradetch [Center for Compound Semiconductors and School of Electrical and Computer Engineering, Georgia Institute of Technology, 777 Atlantic Dr. NW, Atlanta, Georgia 30332-0250 (United States); Yuan, Dajun; Guo, Rui [Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0405 (United States); Liu, Jianping [Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, Suzhou, Jiangsu 215125 (China); Asadirad, Mojtaba [Materials Engineering Program, University of Houston, Houston, Texas 77204-4005 (United States); Kwon, Min-Ki [Department of Photonic Engineering, Chosun University, Seosuk-dong, Gwangju 501-759 (Korea, Republic of); Dupuis, Russell D. [Center for Compound Semiconductors and School of Electrical and Computer Engineering, Georgia Institute of Technology, 777 Atlantic Dr. NW, Atlanta, Georgia 30332-0250 (United States); School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0245 (United States); Das, Suman [Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0405 (United States); School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0245 (United States); Ryou, Jae-Hyun, E-mail: jryou@uh.edu [Materials Engineering Program, University of Houston, Houston, Texas 77204-4005 (United States); Department of Mechanical Engineering and Texas Center for Superconductivity at the University of Houston (TcSUH), University of Houston, Houston, Texas 77204-4006 (United States)

    2014-04-07

    We report on the direct patterning of two-dimensional periodic structures in GaN-based light-emitting diodes (LEDs) through laser interference ablation for the fast and reliable fabrication of periodic micro- and nano-structures aimed at enhancing light output. Holes arranged in a two-dimensional hexagonal lattice array having an opening size of 500 nm, depth of 50 nm, and a periodicity of 1 μm were directly formed by three-beam laser interference without photolithography or electron-beam lithography processes. The laser-patterned LEDs exhibit an enhancement in light output power of 20% compared to conventional LEDs having a flat top surface without degradation of electrical and optical properties of the top p-GaN layer and the active region, respectively.

  16. Gender differences in scalp hair growth rates are maintained but reduced in pattern hair loss compared to controls.

    Science.gov (United States)

    Van Neste, D J J; Rushton, D H

    2016-08-01

    Hair loss is related to follicular density, programmed regrowth and hair productivity. The dissatisfaction with hair growth in patients experiencing hair loss might be due to slower linear hair growth rate (LHGR). LHGR and hair diameter was evaluated in Caucasian controls and patients with patterned hair loss employing the validated non-invasive, contrast-enhanced-phototrichogram with exogen collection. We evaluated 59,765 anagen hairs (controls 24,609, patients 35,156) and found thinner hairs grew slower than thicker hairs. LHGR in normal women was generally higher than in normal men. LHGR correlates with hair diameter (P growth rates. Compared with hair of equal thickness in controls, subjects affected with patterned hair loss showed reduced hair growth rates, an observation found in both male and female patients. Males with pattern hair loss showed further reduction in growth rates as clinical severity worsened. However, sample size limitations prevented statistical evaluation of LHGR in severely affected females. Caucasian ethnicity. In pattern hair loss, LHGR significantly contributes to the apparent decrease in hair volume in affected areas. In early onset, LHRG might have a prognostic value in females but not in males. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. Three-dimensional evaluation of pharyngeal airway in individuals with varying growth patterns using cone beam computed tomography

    OpenAIRE

    Rohan Diwakar; Maninder Singh Sidhu; Mona Prabhakar; Seema Grover; Ritu Phogat

    2015-01-01

    Introduction: The purpose of this study was to evaluate the pharyngeal airway volume in individuals with different vertical growth patterns. Methods: Cone beam computed tomography scans were evaluated of 40 subjects with the age range from 14 to 25 years and were divided into three groups. Horizontal growers consisted of 13 subjects, normal growers consisted of 14 subjects, and the vertical growers consisted of 13 subjects. The pharyngeal airway volume was measured using In Vivo Dental 5.1 so...

  18. Persistent sexual dysfunction and depression in finasteride users for male pattern hair loss: a serious concern or red herring?

    Science.gov (United States)

    Singh, Meena K; Avram, Marc

    2014-12-01

    The use of finasteride for the treatment of male pattern hair loss has recently been the focus of media and internet attention for potential irreversible sexual dysfunction and severe depression. The purpose of this study was to perform a critical review of the recent studies reporting prolonged sexual dysfunction and depression with the use of finasteride for the treatment of male pattern hair loss. A literature search was performed using PubMed to review the literature pertaining to any potential adverse effects with the use of finasteride and its treatment of male pattern hair loss. The authors conclude that the reports of potential irreversible sexual dysfunction and severe depression do raise concerns about the safety of finasteride; however, these studies are wrought with significant bias. Therefore, larger, randomized, double blind, controlled trials are warranted to further ascertain the true potential risks or confirm long-term safety profile of finasteride use.

  19. Patterns and implications of gene gain and loss in the evolution of Prochlorococcus.

    Directory of Open Access Journals (Sweden)

    Gregory C Kettler

    2007-12-01

    Full Text Available Prochlorococcus is a marine cyanobacterium that numerically dominates the mid-latitude oceans and is the smallest known oxygenic phototroph. Numerous isolates from diverse areas of the world's oceans have been studied and shown to be physiologically and genetically distinct. All isolates described thus far can be assigned to either a tightly clustered high-light (HL-adapted clade, or a more divergent low-light (LL-adapted group. The 16S rRNA sequences of the entire Prochlorococcus group differ by at most 3%, and the four initially published genomes revealed patterns of genetic differentiation that help explain physiological differences among the isolates. Here we describe the genomes of eight newly sequenced isolates and combine them with the first four genomes for a comprehensive analysis of the core (shared by all isolates and flexible genes of the Prochlorococcus group, and the patterns of loss and gain of the flexible genes over the course of evolution. There are 1,273 genes that represent the core shared by all 12 genomes. They are apparently sufficient, according to metabolic reconstruction, to encode a functional cell. We describe a phylogeny for all 12 isolates by subjecting their complete proteomes to three different phylogenetic analyses. For each non-core gene, we used a maximum parsimony method to estimate which ancestor likely first acquired or lost each gene. Many of the genetic differences among isolates, especially for genes involved in outer membrane synthesis and nutrient transport, are found within the same clade. Nevertheless, we identified some genes defining HL and LL ecotypes, and clades within these broad ecotypes, helping to demonstrate the basis of HL and LL adaptations in Prochlorococcus. Furthermore, our estimates of gene gain events allow us to identify highly variable genomic islands that are not apparent through simple pairwise comparisons. These results emphasize the functional roles, especially those connected to

  20. Patterns and Implications of Gene Gain and Loss in the Evolution of Prochlorococcus

    Energy Technology Data Exchange (ETDEWEB)

    Lapidus, Alla; Kettler, Gregory C.; Martiny, Adam C.; Huang, Katherine; Zucker, Jeremy; Coleman, Maureen L.; Rodrigue, Sebastien; Chen, Feng; Lapidus, Alla; Ferriera, Steven; Johnson, Justin; Steglich, Claudia; Church, George M.; Richardson, Paul; Chisholm, Sallie W.

    2007-07-30

    Prochlorococcus is a marine cyanobacterium that numerically dominates the mid-latitude oceans and is the smallest known oxygenic phototroph. Numerous isolatesfrom diverse areas of the world's oceans have been studied and shown to be physiologically and genetically distinct. All isolates described thus far can be assigned to either a tightly clustered high-light (HL)-adapted clade, or a more divergent low-light (LL)-adapted group. The 16S rRNA sequences of the entire Prochlorococcus group differ by at most 3percent, and the four initially published genomes revealed patterns of genetic differentiation that help explain physiological differences among the isolates. Here we describe the genomes of eight newly sequenced isolates and combine them with the first four genomes for a comprehensive analysis of the core (shared by all isolates) and flexible genes of the Prochlorococcus group, and the patterns of loss and gain of the flexible genes over the course of evolution. There are 1,273 genes that represent the core shared by all 12 genomes. They are apparently sufficient, according to metabolic reconstruction, to encode a functional cell. We describe a phylogeny for all 12 isolates by subjecting their complete proteomes to three different phylogenetic analyses. For each non-core gene, we used a maximum parsimony method to estimate which ancestor likely first acquired or lost each gene. Many of the genetic differences among isolates, especially for genes involved in outer membrane synthesis and nutrient transport, are found within the same clade. Nevertheless, we identified some genes defining HL and LL ecotypes, and clades within these broad ecotypes, helping to demonstrate the basis of HL and LL adaptations in Prochlorococcus. Furthermore, our estimates of gene gain events allow us to identify highly variable genomic islands that are not apparent through simple pairwise comparisons. These results emphasize the functional roles, especially those connected to outer

  1. Weight Loss Associated With Different Patterns of Self-Monitoring Using the Mobile Phone App My Meal Mate

    OpenAIRE

    Carter, MC; Burley, VJ; Cade, JE

    2017-01-01

    Background Obesity is a major global public health issue due to its association with a number of serious chronic illnesses and its high economic burden to health care providers. Self-monitoring of diet has been consistently linked to weight loss. However, there is limited evidence about how frequently individuals need to monitor their diet for optimal weight loss. Objective The aim of this paper is to describe app usage frequency and pattern in the mobile phone arm of a previously conducted r...

  2. A beam source model for scanned proton beams.

    Science.gov (United States)

    Kimstrand, Peter; Traneus, Erik; Ahnesjö, Anders; Grusell, Erik; Glimelius, Bengt; Tilly, Nina

    2007-06-07

    A beam source model, i.e. a model for the initial phase space of the beam, for scanned proton beams has been developed. The beam source model is based on parameterized particle sources with characteristics found by fitting towards measured data per individual beam line. A specific aim for this beam source model is to make it applicable to the majority of the various proton beam systems currently available or under development, with the overall purpose to drive dose calculations in proton beam treatment planning. The proton beam phase space is characterized by an energy spectrum, radial and angular distributions and deflections for the non-modulated elementary pencil beam. The beam propagation through the scanning magnets is modelled by applying experimentally determined focal points for each scanning dimension. The radial and angular distribution parameters are deduced from measured two-dimensional fluence distributions of the elementary beam in air. The energy spectrum is extracted from a depth dose distribution for a fixed broad beam scan pattern measured in water. The impact of a multi-slab range shifter for energy modulation is calculated with an own Monte Carlo code taking multiple scattering, energy loss and straggling, non-elastic and elastic nuclear interactions in the slab assembly into account. Measurements for characterization and verification have been performed with the scanning proton beam system at The Svedberg Laboratory in Uppsala. Both in-air fluence patterns and dose points located in a water phantom were used. For verification, dose-in-water was calculated with the Monte Carlo code GEANT 3.21 instead of using a clinical dose engine with approximations of its own. For a set of four individual pencil beams, both with the full energy and range shifted, 96.5% (99.8%) of the tested dose points satisfied the 1%/1 mm (2%/2 mm) gamma criterion.

  3. Patterns of hybrid loss of imprinting reveal tissue- and cluster-specific regulation.

    Directory of Open Access Journals (Sweden)

    Christopher D Wiley

    Full Text Available Crosses between natural populations of two species of deer mice, Peromyscus maniculatus (BW, and P. polionotus (PO, produce parent-of-origin effects on growth and development. BW females mated to PO males (bwxpo produce growth-retarded but otherwise healthy offspring. In contrast, PO females mated to BW males (POxBW produce overgrown and severely defective offspring. The hybrid phenotypes are pronounced in the placenta and include POxBW conceptuses which lack embryonic structures. Evidence to date links variation in control of genomic imprinting with the hybrid defects, particularly in the POxBW offspring. Establishment of genomic imprinting is typically mediated by gametic DNA methylation at sites known as gDMRs. However, imprinted gene clusters vary in their regulation by gDMR sequences.Here we further assess imprinted gene expression and DNA methylation at different cluster types in order to discern patterns. These data reveal POxBW misexpression at the Kcnq1ot1 and Peg3 clusters, both of which lose ICR methylation in placental tissues. In contrast, some embryonic transcripts (Peg10, Kcnq1ot1 reactivated the silenced allele with little or no loss of DNA methylation. Hybrid brains also display different patterns of imprinting perturbations. Several cluster pairs thought to use analogous regulatory mechanisms are differentially affected in the hybrids.These data reinforce the hypothesis that placental and somatic gene regulation differs significantly, as does that between imprinted gene clusters and between species. That such epigenetic regulatory variation exists in recently diverged species suggests a role in reproductive isolation, and that this variation is likely to be adaptive.

  4. Adaptive Patterns of Mitogenome Evolution Are Associated with the Loss of Shell Scutes in Turtles.

    Science.gov (United States)

    Escalona, Tibisay; Weadick, Cameron J; Antunes, Agostinho

    2017-10-01

    The mitochondrial genome encodes several protein components of the oxidative phosphorylation (OXPHOS) pathway and is critical for aerobic respiration. These proteins have evolved adaptively in many taxa, but linking molecular-level patterns with higher-level attributes (e.g., morphology, physiology) remains a challenge. Turtles are a promising system for exploring mitochondrial genome evolution as different species face distinct respiratory challenges and employ multiple strategies for ensuring efficient respiration. One prominent adaptation to a highly aquatic lifestyle in turtles is the secondary loss of keratenized shell scutes (i.e., soft-shells), which is associated with enhanced swimming ability and, in some species, cutaneous respiration. We used codon models to examine patterns of selection on mitochondrial protein-coding genes along the three turtle lineages that independently evolved soft-shells. We found strong evidence for positive selection along the branches leading to the pig-nosed turtle (Carettochelys insculpta) and the softshells clade (Trionychidae), but only weak evidence for the leatherback (Dermochelys coriacea) branch. Positively selected sites were found to be particularly prevalent in OXPHOS Complex I proteins, especially subunit ND2, along both positively selected lineages, consistent with convergent adaptive evolution. Structural analysis showed that many of the identified sites are within key regions or near residues involved in proton transport, indicating that positive selection may have precipitated substantial changes in mitochondrial function. Overall, our study provides evidence that physiological challenges associated with adaptation to a highly aquatic lifestyle have shaped the evolution of the turtle mitochondrial genome in a lineage-specific manner. © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  5. Fabricating a regular hexagonal lattice structure by interference pattern of six femtosecond laser beams

    Science.gov (United States)

    Nakata, Yoshiki; Yoshida, Masataka; Osawa, Kazuhito; Miyanaga, Noriaki

    2017-09-01

    Interference of six countering femtosecond (fs) laser beams at a wavelength of 785 nm has been utilized to fabricate nanostructures in a regular hexagonal lattice. A diffractive-optical element for six-beam splitting was introduced to a beam correlation system. The lattice structure was in accordance with the simulated structure based on the principle of superposition of electric fields. The unit structures fabricated on gold thin films were nanobit, nanodrop, and metallic hole array. The height and diameter of a representative nanodrop were 450 and 210 nm, respectively. Molten structures such as nanodrops are believed to have been fabricated via a solid-liquid-solid (SLS) mechanism, as in the case of previous experiments using four beams. In addition, multi-shot processing is examined to fabricate through-holes at lower fluences.

  6. Male pattern hair loss: Taking one for the team: The selfless gene.

    Science.gov (United States)

    Uzoigwe, Chika Edward; Sanchez Franco, Luis Carlos; Gascon Conde, Ignacio; Sanchez Campoy, Adrian

    2018-05-01

    Male pattern hair loss (MPHL) is exceedingly common. It is characterised by onset in early adulthood and progression with age. It has a strong heritable component. The reason for its existence remains unexplained. Given that MPHL is progressive and has its earliest manifestations in young adults it may be a barometer of age. Here we suggest that MPHL may have atavistically allowed women in our species and ancestor species to select younger (but not necessarily the youngest) adult mates. Evidence suggests that conceptions by younger fathers are more likely to lead to live births and less likely to result in miscarriage. Further children fathered by younger men may have improved health and be less likely to suffer from a number of co-morbidities. This is collectively known as the "paternal age affect". Hence the selection of younger males mediated by the MPHL may improve the fitness of the population and of the species at the expense of the individual. Indeed MPHL may have been an evolutionary "nudge" directing women to favour younger partners. It is conceivable that for a species whose success is predicated upon co-operation, collaboration and altruism the gene cannot be exclusively selfish and must have a selfless allele. Copyright © 2018 Elsevier Ltd. All rights reserved.

  7. Service Delivery to Children With Mild Hearing Loss: Current Practice Patterns and Parent Perceptions.

    Science.gov (United States)

    Walker, Elizabeth A; Spratford, Meredith; Ambrose, Sophie E; Holte, Lenore; Oleson, Jacob

    2017-03-01

    This study investigates clinical practice patterns and parent perception of intervention for children with mild hearing loss (HL). Ages at and delays between service delivery steps (first diagnostic evaluation, confirmation of HL, hearing aid [HA] fitting, entry into early intervention) were investigated for 113 children with mild HL. Comparisons were made to children with moderate-to-severe HL. Parents of children with mild HL reported reasons for delays and their perceptions of intervention and amplification for their children. Seventy-four percent of children with mild HL were identified through the newborn hearing screen; 26% were identified later due to passing or not receiving a newborn hearing screen. Ninety-four percent of children with mild HL were fit with HAs, albeit at significantly later ages than children with moderate-to-severe HL. Most parents indicated that their children benefited from HA use, but some parents expressed ambivalence toward the amount of benefit. Audiologists appear to be moving toward regularly providing amplification for children with mild HL. However, delays in HA fittings indicate that further educating professionals and parents about the benefits of early amplification and intervention is warranted to encourage timely fitting and consistent use of HAs.

  8. The prognostic significance of Gleason pattern 5 in prostate cancer patients treated with Pd 103 plus beam radiation therapy.

    Science.gov (United States)

    Sherertz, Tracy; Wallner, Kent; Merrick, Gregory; Cavanagh, William; Butler, Wayne; Reed, Daniel; True, Lawrence

    2004-01-01

    There is little clinical information specifically regarding the clinical significance of Gleason pattern 5 in prostate biopsies. Accordingly, we have analyzed the effect of pattern 5 cancer on the prognosis of prostate cancer treated with Pd-103 brachytherapy. Intermediate-risk patients with a Gleason score of 7 or higher and/or a prostate-specific antigen level of 10-20 ng/mL and whose biopsy slides were available for review were treated on a randomized trial. The regimens consisted of implantation with Pd 103 (90 vs 115 Gy [National Institute of Standards and Technology; NIST-1999]), combined with 44 Gy versus 20 Gy of supplemental beam radiation, respectively. Beam radiation was delivered with a four-field arrangement, designed to cover the prostate and seminal vesicles with a 2-cm margin (reduced to 1.0 cm posteriorly). Isotope implantation was per formed by standard techniques, using a modified peripheral loading pattern. All prostate biopsy specimens were reviewed for Gleason score by one investigator (L. T.). Along with assignment of a Gleason score based on established criteria, the presence of any pattern 5 cancer was separately noted and photographed for future review. Freedom from biochemical failure was defined as a serum prostate-specific antigen level systemic failure, we are encouraged that high-dose, brachytherapy-based treatment seems to provide a high likelihood of biochemical cancer control, even in patients with the highest-grade cancer.

  9. Beam-loss induced pressure rise of Large Hadron Collider collimator materials irradiated with 158 GeV/u $In^{49+}$ ions at the CERN Super Proton Synchrotron

    CERN Document Server

    Mahner, Edgar; Hansen, Jan; Page, Eric; Vincke, H

    2004-01-01

    During heavy ion operation, large pressure rises, up to a few orders of magnitude, were observed at CERN, GSI, and BNL. The dynamic pressure rises were triggered by lost beam ions that impacted onto the vacuum chamber walls and desorbed about 10/sup 4/ to 10/sup 7/ molecules per ion. The deterioration of the dynamic vacuum conditions can enhance charge-exchange beam losses and can lead to beam instabilities or even to beam abortion triggered by vacuum interlocks. Consequently, a dedicated measurement of heavy-ion induced molecular desorption in the GeV/u energy range is important for Large Hadron Collider (LHC) ion operation. In 2003, a desorption experiment was installed at the super proton synchrotron to measure the beam-loss induced pressure rise of potential LHC collimator materials. Samples of bare graphite, sputter coated (Cu, TiZrV) graphite, and 316 LN (low carbon with nitrogen) stainless steel were irradiated under grazing angle with 158 GeV/u indium ions. After a description of the new experimental ...

  10. Technical Note: Validation of halo modeling for proton pencil beam spot scanning using a quality assurance test pattern

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Liyong, E-mail: linl@uphs.upenn.edu; Huang, Sheng; Kang, Minglei; Solberg, Timothy D.; McDonough, James E.; Ainsley, Christopher G. [Department of Radiation Oncology, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 (United States)

    2015-09-15

    Purpose: The purpose of this paper is to demonstrate the utility of a comprehensive test pattern in validating calculation models that include the halo component (low-dose tails) of proton pencil beam scanning (PBS) spots. Such a pattern has been used previously for quality assurance purposes to assess spot shape, position, and dose. Methods: In this study, a scintillation detector was used to measure the test pattern in air at isocenter for two proton beam energies (115 and 225 MeV) of two IBA universal nozzles (UN #1 and UN #2). Planar measurements were compared with calculated dose distributions based on the weighted superposition of location-independent (UN #1) or location-dependent (UN #2) spot profiles, previously measured using a pair-magnification method and between two nozzles. Results: Including the halo component below 1% of the central dose is shown to improve the gamma-map comparison between calculation and measurement from 94.9% to 98.4% using 2 mm/2% criteria for the 115 MeV proton beam of UN #1. In contrast, including the halo component below 1% of the central dose does not improve the gamma agreement for the 115 MeV proton beam of UN #2, due to the cutoff of the halo component at off-axis locations. When location-dependent spot profiles are used for calculation instead of spot profiles at central axis, the gamma agreement is improved from 98.0% to 99.5% using 2 mm/2% criteria. The two nozzles clearly have different characteristics, as a direct comparison of measured data shows a passing rate of 89.7% for the 115 MeV proton beam. At 225 MeV, the corresponding gamma comparisons agree better between measurement and calculation, and between measurements in the two nozzles. Conclusions: In addition to confirming the primary component of individual PBS spot profiles, a comprehensive test pattern is useful for the validation of the halo component at off-axis locations, especially for low energy protons.

  11. Study of pattern transition in nanopatterned Si(100) produced by impurity-assisted low-energy ion-beam erosion

    Science.gov (United States)

    Koyiloth Vayalil, Sarathlal; Gupta, Ajay; Roth, Stephan V.

    2017-04-01

    In this work, formation of self-organized Si nanostructures induced by pure Fe incorporation during normal incidence low-energy (1keV) Ar^+ ion bombardment is presented. It has been observed that the incorporation of Fe affects the evolution of the surface topography. The addition of Fe generates pronounced nanopatterns, such as dots, ripples and combinations of dots and ripples. The orientation of the ripple wave vector of the patterns formed is found to be in a direction normal to the Fe flow. The nanoripples with wavelength of the order of 39 nm produced is expected to be the lowest wavelength of the patterns reported on ion-beam-eroded structures under the incorporation of metallic impurities as per our knowledge. From the AFM and GISAXS analysis, it has been confirmed that the ripples formed are asymmetric in nature. The effect of the concentration of the Fe on morphological transition of the patterns has been studied using Rutherford backscattering measurements.

  12. E-beam patterning of CoFeB/MgO/CoFeB-based magnetic tunneljunctions

    Energy Technology Data Exchange (ETDEWEB)

    Leutenantsmeyer, Johannes Christian; Walter, Marvin; Zbarsky, Vladyslav; Muenzenberg, Markus [I. Physikalisches Institut, Georg-August-Universitaet Goettingen, 37077 Goettingen (Germany); Schuhmann, Henning; Seibt, Michael [IV. Physikalisches Institut, Georg-August-Universitaet Goettingen, 37077 Goettingen (Germany)

    2011-07-01

    The tunnel magnetoresistance (TMR) in magnetic tunnel junctions (MTJs) is suitable for various applications such as next generation RAM-Cells, the MRAM. Our MTJs are fabricated by magnetron sputtered CoFeB and Ta and further e-beam evaporated material such as the MgO-barrier. After patterning, the samples are characterized by R(H) measurements and optical hysteresis loop measurements. The samples show up to 200% TMR. Since spin-transfer torque requires smaller dimensions we investigate downscaling of the junction size. We expect this to improve the switching behavior and increase the TMR-ratio of our MTJs. Thus we present a study of e-beam lithography, which gives us the capability to produce MTJs below 1 {mu} m edge length. We also aquire the ability to produce different shaped structures, with the aim to investigate the MTJs' structural anisotropy to optimize magnetic switching. Research is supported by the DFG through SFB 602.

  13. Change in sympathetic nerve firing pattern associated with dietary weight loss in the metabolic syndrome

    Directory of Open Access Journals (Sweden)

    Elisabeth Annie Lambert

    2011-08-01

    Full Text Available Sympathetic activation in subjects with the metabolic syndrome (MS plays a role in the pathogenesis of cardiovascular disease development. Diet-induced weight loss decreases sympathetic outflow. However the mechanisms that account for sympathetic inhibition are not known. We sought to provide a detailed description of the sympathetic response to diet by analyzing the firing behavior of single-unit sympathetic nerve fibres. Fourteen subjects (57±2 years, 9 men, 5 females fulfilling ATP III criteria for the MS underwent a 3-month low calorie diet. Metabolic profile, hemodynamic parameters and multi-unit and single unit muscle sympathetic nerve activity (MSNA, microneurography were assessed prior to and at the end of the diet. Patients’ weight dropped from 96±4 to 88±3 kg (P<0.001. This was associated with a decrease in systolic and diastolic blood pressure (-12 ±3 and -5±2 mmHg, P<0.05, and in heart rate (-7±2 bpm, P<0.01 and an improvement in all metabolic parameters (fasting glucose: -0.302.1±0.118 mmol/l, total cholesterol: -0.564±0.164 mmol/l, triglycerides: -0.414±0.137 mmol/l, P<0.05. Multi-unit MSNA decreased from 68±4 to 59±5 bursts per 100 heartbeats (P<0.05. Single-unit MSNA indicated that the firing rate of individual vasoconstrictor fibres decreased from 59±10 to 32±4 spikes per 100 heart beats (P<0.05. The probability of firing decreased from 34±5 to 23±3 % of heartbeats (P<0.05, and the incidence of multiple firing decreased from 14±4 to 6±1 % of heartbeats (P<0.05. Cardiac and sympathetic baroreflex function were significantly improved (cardiac slope: 6.57±0.69 to 9.57±1.20 msec.mmHg-1; sympathetic slope: -3.86±0.34 to -5.05±0.47 bursts per 100 heartbeats.mmHg-1 P<0.05 for both. Hypocaloric diet decreased sympathetic activity and improved hemodynamic and metabolic parameters. The sympathoinhibition associated with weight loss involves marked changes, not only in the rate but also in the firing pattern of

  14. Spatial patterns of progressive brain volume loss after moderate-severe traumatic brain injury

    Science.gov (United States)

    Jolly, Amy; de Simoni, Sara; Bourke, Niall; Patel, Maneesh C; Scott, Gregory; Sharp, David J

    2018-01-01

    Abstract Traumatic brain injury leads to significant loss of brain volume, which continues into the chronic stage. This can be sensitively measured using volumetric analysis of MRI. Here we: (i) investigated longitudinal patterns of brain atrophy; (ii) tested whether atrophy is greatest in sulcal cortical regions; and (iii) showed how atrophy could be used to power intervention trials aimed at slowing neurodegeneration. In 61 patients with moderate-severe traumatic brain injury (mean age = 41.55 years ± 12.77) and 32 healthy controls (mean age = 34.22 years ± 10.29), cross-sectional and longitudinal (1-year follow-up) brain structure was assessed using voxel-based morphometry on T1-weighted scans. Longitudinal brain volume changes were characterized using a novel neuroimaging analysis pipeline that generates a Jacobian determinant metric, reflecting spatial warping between baseline and follow-up scans. Jacobian determinant values were summarized regionally and compared with clinical and neuropsychological measures. Patients with traumatic brain injury showed lower grey and white matter volume in multiple brain regions compared to controls at baseline. Atrophy over 1 year was pronounced following traumatic brain injury. Patients with traumatic brain injury lost a mean (± standard deviation) of 1.55% ± 2.19 of grey matter volume per year, 1.49% ± 2.20 of white matter volume or 1.51% ± 1.60 of whole brain volume. Healthy controls lost 0.55% ± 1.13 of grey matter volume and gained 0.26% ± 1.11 of white matter volume; equating to a 0.22% ± 0.83 reduction in whole brain volume. Atrophy was greatest in white matter, where the majority (84%) of regions were affected. This effect was independent of and substantially greater than that of ageing. Increased atrophy was also seen in cortical sulci compared to gyri. There was no relationship between atrophy and time since injury or age at baseline. Atrophy rates were related to memory performance at the end of the

  15. Developer molecular size dependence of pattern formation of polymer type electron beam resists with various molecular weights

    Science.gov (United States)

    Takayama, Tomohiro; Asada, Hironori; Kishimura, Yukiko; Ochiai, Shunsuke; Hoshino, Ryoichi; Kawata, Atsushi

    2016-05-01

    The sensitivity and the resolution are affected by not only the nature of the resist such as a chemical structure and a molecular weight but also the developing process such as a developer molecular size. Exposure characteristics of positive-tone polymer resists having various molecular weights (Mw's) ranging from 60 k to 500 k are investigated using different ester solvents as a developer. The line-and-space (L/S) patterns are exposed by the electron beam writing system with an acceleration voltage of 50 kV and the samples are developed by amyl acetate, hexyl acetate and heptyl acetate. The pattern shape becomes better and the surface of the resist also becomes smoother with increasing developer molecular size, though the exposure dose required for the formation of the L/S pattern increases. The dose margin of pattern formation is also wider in all the resists having the different molecular weights. The dissolution in the unexposed portions of the 60k-Mw resist for heptyl acetate is reduced significantly compared with those for amyl acetate and hexyl acetate. The improvement of the pattern shape and the increasing of dose margin are remarkable in the low molecular weight resist. The 3σ of line width roughness tends to be smaller in the higher molecular weight resist and with the larger molecular size developer. Exposure experiment of the 35 nm pitch pattern using the 500k-Mw resist developed at the room temperature is presented.

  16. 5 mg/day finasteride treatment for normoandrogenic Asian women with female pattern hair loss.

    Science.gov (United States)

    Yeon, J H; Jung, J Y; Choi, J W; Kim, B J; Youn, S W; Park, K C; Huh, C H

    2011-02-01

    Various treatments have been attempted for female pattern hair loss (FPHL), including topical minoxidil, oral antiandrogen and finasteride. But, there is no consensus on the standard treatment options. Clinical efficacy of finasteride in treating FPHL is still in controversy, but there is a tendency to high dose finasteride, which is more effective than lower dose. The purpose of this study was to evaluate the clinical efficacy of high dose (5 mg/day) oral finasteride in normoandrogenic Asian women with FPHL. Total of 87 normoandrogenic, pre and post-menopausal women with FPHL were enrolled in this study. They were treated with oral finasteride (Proscar(®)), 5 mg daily for 12 months. Efficacy was evaluated with hair density and thickness changes assessed by phototrichogram and global photographs using 7-point scale. Eighty-six patients completed 12 months of finasteride treatment schedule. One patient (1.1%) withdrew due to headache. At initial visits, mean hair density was 90 ± 22/cm(2) and mean hair thickness was 64 ± 11 μm. After 12 months of finasteride treatment, hair density was significantly increased to 107 ± 23/cm(2) (Phair thickness was also significantly increased to 70 ± 9 μm (P=0.02). In global photographs, 70 (81.4%) of the 86 patients were improved (57 were slightly, 10 were moderately and four were greatly improved). Patients without any changes were 13 (15.1%) and 3 (3.5%) patients reported slightly aggravated. Four patients (4.6%) reported adverse events (headache, menstrual irregularity, dizziness and increased body hair growth). However, these adverse events were mild and disappeared soon.   Oral finasteride, 5 mg/day, may be an effective and safe treatment for normoandrogenic women with FPHL. © 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.

  17. High-resolution direct-write patterning using focused ion beams

    NARCIS (Netherlands)

    Ocola, L.E.; Rue, C.; Maas, D.J.

    2014-01-01

    Over the last few years, significant improvements in sources, columns, detectors, control software, and accessories have enabled a wealth of new focused ion beam applications. In addition, modeling has provided many insights into ion-sample interactions and the resultant effects on the sample. With

  18. Fabrication of phonon-based metamaterial structures using focused ion beam patterning

    Science.gov (United States)

    Bassim, Nabil D.; Giles, Alexander J.; Ocola, Leonidas E.; Caldwell, Joshua D.

    2018-02-01

    The focused ion beam (FIB) is a powerful tool for rapid prototyping and machining of functional nanodevices. It is employed regularly to fabricate test metamaterial structures but, to date, has been unsuccessful in fabricating metamaterial structures with features at the nanoscale that rely on surface phonons as opposed to surface plasmons because of the crystalline damage that occurs with the collision cascade associated with ion sputtering. In this study, we employ a simple technique of protecting the crystalline substrate in single-crystal 4H-SiC to design surface phonon polariton-based optical resonance structures. By coating the material surface with a thin film of chromium, we have placed a material of high sputter resistance on the surface, which essentially absorbs the energy in the beam tails. When the beam ultimately punches through the Cr film, the hard walls in the film have the effect of channeling the beam to create smooth sidewalls. This demonstration opens the possibility of further rapid-prototyping of metamaterials using FIB.

  19. Psychiatric Factors and Weight Loss Patterns Following Gastric Bypass Surgery in a Veteran Population

    OpenAIRE

    Rutledge, Thomas; Groesz, Lisa M.; Savu, Michelle

    2009-01-01

    Background Although pre-surgical psychological evaluations are commonly administered to patients considered for weight loss surgeries, the value of these evaluations for predicting weight loss success has been questioned. In this study, we addressed this issue by examining patient’s total number of psychiatric indicators rather than individual psychological factors as predictors of weight loss/weight regain. Methods Sixty adult veterans completed gastric bypass surgery or laparoscopic gastric...

  20. Comparative study between cold plasma and hot plasma with ion beam and loss-cone distribution function by particle aspect approach

    International Nuclear Information System (INIS)

    Patel, Soniya; Varma, P; Tiwari, M S

    2011-01-01

    The electromagnetic ion-cyclotron (EMIC) instabilities with isotropic ion beam and general loss-cone distribution of cold and hot core plasmas are discussed. The growth rate, parallel and perpendicular resonance energies of the electromagnetic ion-cyclotron waves in a low β (ratio of plasma pressure to magnetic pressure), homogeneous plasma have been obtained using the dispersion relation for cold and hot plasmas. The wave is assumed to propagate parallel to the static magnetic field. The whole plasma is considered to consist of resonant and non-resonant particles permeated by isotropic ion beam. It is assumed that resonant particles and ion beam participate in energy exchange with the wave whereas non-resonant particles support the oscillatory motion of the wave. We determined the variation in energies and growth rate in cold and hot plasmas by the energy conservation method with a general loss-cone distribution function. The thermal anisotropy of the core plasma acts as a source of free energy for EMIC wave and enhances the growth rate. It is noted that the EMIC wave emissions occur by extracting energy of perpendicularly heated ions in the presence of up flowing ion beam and steep loss-cone distribution in the anisotropic magnetosphere. The effect of the steep loss-cone distribution is to enhance the growth rate of the EMIC wave. The heating of ions perpendicular and parallel to the magnetic field is discussed along with EMIC wave emission in the auroral acceleration region. The results are interpreted for the space plasma parameters appropriate to the auroral acceleration region of the earth's magnetoplasma.

  1. Single-mirror beam steering system: analysis and synthesis of high-order conic-section scan patterns

    Science.gov (United States)

    Li, Yajun

    2008-01-01

    The vector approach introduced in an early paper for modeling mirror-scanning devices [Y. Li, Appl. Opt. 34, 6417 (1995)] provides the basis of a rigorous study of the scan field generated by a single-mirror beam steering system, in which a hinged movable mirror is able to turn about a fixed pivot point to steering a single laser beam. Because of fewer constraints on mirror angular motion, the system may behave like a true point source for both vector and raster scanning applications. After a summary of the expressions for scan fields generated under different conditions, some fundamental and advanced topics of the single-mirror system are addressed: (1) basic parameters of high-order conic-section scan patterns, (2) scanning spot kinematics, (3) effect of input offset and pixels distortions on two-dimensional images displayed on screens of different formats, (4) mapping and its inverse between the mirror vector space and the scan vector space, and (5) single-mirror beam steering system as a one-element reflective and continuous image zooming device.

  2. Beam loss caused by edge focusing of injection bump magnets and its mitigation in the 3-GeV rapid cycling synchrotron of the Japan Proton Accelerator Research Complex

    Directory of Open Access Journals (Sweden)

    H. Hotchi

    2016-01-01

    Full Text Available In the 3-GeV rapid cycling synchrotron of the Japan Proton Accelerator Research Complex, transverse injection painting is utilized not only to suppress space-charge induced beam loss in the low energy region but also to mitigate foil scattering beam loss during charge-exchange injection. The space-charge induced beam loss is well minimized by the combination of modest transverse painting and full longitudinal painting. But, for sufficiently mitigating the foil scattering part of beam loss, the transverse painting area has to be further expanded. However, such a wide-ranging transverse painting had not been realized until recently due to beta function beating caused by edge focusing of pulsed injection bump magnets during injection. This beta function beating additionally excites random betatron resonances through a distortion of the lattice superperiodicity, and its resultant deterioration of the betatron motion stability causes significant extra beam loss when expanding the transverse painting area. To solve this issue, we newly installed pulse-type quadrupole correctors to compensate the beta function beating. This paper presents recent experimental results on this correction scheme for suppressing the extra beam loss, while discussing the beam loss and its mitigation mechanisms with the corresponding numerical simulations.

  3. Causes and pattern of tooth loss in children and adolescents in a ...

    African Journals Online (AJOL)

    Information obtained included age, gender, missing and extracted teeth, and reasons for extraction/tooth loss. Exfoliated primary teeth and congenitally missing teeth were excluded. Data was analysed using Epi info 2007 statistical software. Chi-square test was used to compare proportions of tooth loss among age groups.

  4. The directed self-assembly for the surface patterning by electron beam II

    Science.gov (United States)

    Nakagawa, Sachiko T.

    2015-03-01

    When a low-energy electron beam (EB) or a low-energy ion beam (IB) irradiates a crystal of zincblende (ZnS)-type as crystalline Si (c-Si), a very similar {311} planar defect is often observed. Here, we used a molecular dynamics simulation for a c-Si that included uniformly distributed Frenkel-pairs, assuming a wide beam and sparse distribution of defects caused by each EB. We observed the formation of ? linear defects, which agglomerate to form planar defects labeled with the Miller index {311} as well as the case of IB irradiation. These were identified by a crystallographic analysis called pixel mapping (PM) method. The PM had suggested that self-interstitial atoms may be stabilized on a specific frame of a lattice made of invisible metastable sites in the ZnS-type crystal. This agglomeration appears as {311} planar defects. It was possible at a much higher temperature than room temperature,for example, at 1000 K. This implies that whatever disturbance may bring many SIAs in a ZnS-type crystal, elevated lattice vibration promotes self-organization of the SIAs to form {311} planar defects according to the frame of metastable lattice as is guided by a chart presented by crystallography.

  5. Pattern generation using axicon lens beam shaping in two-photon polymerisation

    Science.gov (United States)

    Bhuian, B.; Winfield, R. J.; O'Brien, S.; Crean, G. M.

    2007-12-01

    The fabrication of three-dimensional microstructures by two-photon polymerisation has been widely reported as a viable route to the development of photonic crystals, rotors, bridges and other complex artefacts requiring nanoscale resolution. Conventionally, single point serial writing is used to write the structures but recently multipoint beam delivery using beam division optics has been reported as a method of introducing parallel processing. In this paper we present an alternative and novel approach using an axicon lens to give profiled beam delivery. This enables complete three-dimensional annular structure fabrication without the use of scanning stages. In addition, the concept of axicon delivery is developed further to investigate three-dimensional structure as a function of axicon geometry. A Ti:sapphire laser, with wavelength 795 nm, 80 MHz repetition rate, 100 fs pulse duration and an average power of 700 mW, was used to initiate two-photon polymerisation. The axicon was used, in combination with a 100× microscope objective, to form representative three-dimensional structures based on the annular cell with varying diameter. The structures were written in a Zr-loaded resin prepared on a glass substrate using dip coating deposition of a Zr/PMMA hybrid prepared by the sol-gel method. Annuli with diameters up to 50 μm were characterised in terms of topography and surface roughness using SEM and Zygo interferometer. The writing technique was also extended to fabrication of stacked structures.

  6. Pattern generation using axicon lens beam shaping in two-photon polymerisation

    Energy Technology Data Exchange (ETDEWEB)

    Bhuian, B. [Tyndall National Institute, Lee Maltings, Prospect Row, Cork (Ireland); Department of Microelectronic Engineering, University College Cork, Cork (Ireland); Winfield, R.J. [Tyndall National Institute, Lee Maltings, Prospect Row, Cork (Ireland)], E-mail: richard.winfield@tyndall.ie; O' Brien, S. [Tyndall National Institute, Lee Maltings, Prospect Row, Cork (Ireland); Crean, G.M. [Tyndall National Institute, Lee Maltings, Prospect Row, Cork (Ireland); Department of Microelectronic Engineering, University College Cork, Cork (Ireland)

    2007-12-15

    The fabrication of three-dimensional microstructures by two-photon polymerisation has been widely reported as a viable route to the development of photonic crystals, rotors, bridges and other complex artefacts requiring nanoscale resolution. Conventionally, single point serial writing is used to write the structures but recently multipoint beam delivery using beam division optics has been reported as a method of introducing parallel processing. In this paper we present an alternative and novel approach using an axicon lens to give profiled beam delivery. This enables complete three-dimensional annular structure fabrication without the use of scanning stages. In addition, the concept of axicon delivery is developed further to investigate three-dimensional structure as a function of axicon geometry. A Ti:sapphire laser, with wavelength 795 nm, 80 MHz repetition rate, 100 fs pulse duration and an average power of 700 mW, was used to initiate two-photon polymerisation. The axicon was used, in combination with a 100x microscope objective, to form representative three-dimensional structures based on the annular cell with varying diameter. The structures were written in a Zr-loaded resin prepared on a glass substrate using dip coating deposition of a Zr/PMMA hybrid prepared by the sol-gel method. Annuli with diameters up to 50 {mu}m were characterised in terms of topography and surface roughness using SEM and Zygo interferometer. The writing technique was also extended to fabrication of stacked structures.

  7. Hybrid deburring process assisted by a large pulsed electron beam (LPEB) for laser-fabricated patterned metal masks

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jisoo; Park, Hyung Wook, E-mail: hwpark@unist.ac.kr

    2015-12-01

    Highlights: • Patterned metal masks made of AISI 304 stainless steel were fabricated by fiber-laser. • Abrasive deburring alone, large pulsed electron beam (LPEB) deburring alone, and hybrid deburring process assisted by LPEB were performed. • A numerical heat transfer model for LPEB irradiation approximately predicted the melting depths and experimental studies revealed the limitation on eliminating burr size of LPEB irradiation alone. • The size of remaining burrs after the hybrid deburring process was reduced to7.2 μm. • The surface roughness (Ra) following the hybrid deburring process was reduced from 640 nm to 121 nm indicating a relatively uniform surface texture. - Abstract: The quality of pixels on displays and semiconductors is directly related to the surface quality of the patterned metal mask used. Burrs generated on the patterned metal mask can degrade the quality of pixels on microelectronic devices during the deposition process. In this study, experimental observations of abrasive deburring along with large pulsed electron beam (LPEB) irradiation were performed to evaluate the deburring effects on patterned metal masks. Numerical modeling of LPEB irradiation approximately predicted melting depths and the experimental studies revealed limitations in the size of burrs removed by LPEB irradiation. Thus a LPEB-assisted hybrid deburring process was developed to eliminate burrs of metal masks regardless of their size. The size of burrs remaining after the LPEB-assisted hybrid deburring process was reduced to approximately 7.2 μm which was much less than the results of abrasive deburring alone (38.01 μm). The burr size distribution was reduced by 85% and surface roughness (Ra) was decreased from 640 nm to 121 nm, indicating a uniform surface texture.

  8. Simulation of AZ-PN100 resist pattern fluctuation in X-ray lithography, including synchrotron beam polarization

    International Nuclear Information System (INIS)

    Scheckler, E.W.; Ogawa, Taro; Tanaka, Toshihiko; Takeda, Eiji; Oizumi, Hiroaki.

    1993-01-01

    A new simulation model for nanometer-scale pattern fluctuation in X-ray lithography is presented and applied to a study of AZ-PN100 negative chemical amplification resist. The exposure simulation considers polarized photons from a synchrotron radiation (SR) source. Monte Carlo simulation of Auger and photoelectron generation is followed by electron scattering simulation to determine the deposited energy distribution at the nanometer scale, including beam polarization effects. An acid-catalyst random walk model simulates the post-exposure bake (PEB) step. Fourier transform infrared (FTIR) spectroscopy and developed resist thickness measurements are used to fit PEB and rate models for AZ-PN100. A polymer removal model for development simulation predicts the macroscopic resist shape and pattern roughness. The simulated 3σ linewidth variation is in excess of 24 nm. Simulation also shows a detrimental effect if the beam polarization is perpendicular to the line. Simulation assuming a theoretical ideal exposure yields a 50 nm minimum line for standard process conditions. (author)

  9. Velocity measurements and identification of the flow pattern of vertical air-water flows with light-beam detectors

    International Nuclear Information System (INIS)

    Luebbesmeyer, D.; Leoni, B.

    1980-07-01

    A new detector for measuring fluid velocities in two-phase flows by means of Noise-Analysis (especially Transient-Cross-Correlation-technique) has been developed. The detector utilizes a light-beam which is modulated by changes in the transparency of the two-phase flow. The results of nine measurements for different flow-regimes of vertical air/water-flows are shown. A main topic of these investigations was to answer the question if it is possible to identify the flow-pattern by looking at the shape of different 'Noise-Analytical-functions' (like APSD, CPSD, CCF etc.). The results prove that light-beam sensors are good detectors for fluid-velocity measurements in different flow regimes and in a wide range of fluid velocities starting with values of about 0.08 m/s up to values of 40 m/s. With respect to flow-pattern identification only the time-signals and the shape of the cross-power-density-function (CPSD) seem to be useful. (Auth.)

  10. Spatial pattern of mass loss processes across the Greenland Ice Sheet from the Little Ice Age to 2010

    DEFF Research Database (Denmark)

    Kjaer, K. H.; Korsgaard, N. J.; Kjeldsen, K. K.

    The Greenland Ice Sheet loses mass through surface meltwater runoff and discharge from marine terminating outlet glaciers. The spatial variability and magnitude of these processes have been studied and described in detail for the past decades. Here, we combine the mass loss between the LIA to 2010...... (ICESat) from 2003-2009, NASA's Land, Vegetation, and Ice Sensor (LVIS) from 2010, and ASTER (Silcast AST14DMO) co-registered to ICESat, to estimate mass loss throughout the 20th and early 21st Century. The mass balance estimates of the GrIS since retreat from maximum LIA is combined with a SMB model...... correspond to those that experienced considerable thinning throughout the 20th century. Consequently, comparing the 20th century thinning pattern to that of the last decade, and assuming a similar warming pattern, we argue that the present sensitivity distribution will hold also for future ice sheet mass...

  11. Habitat Loss, Not Fragmentation, Drives Occurrence Patterns of Canada Lynx at the Southern Range Periphery

    OpenAIRE

    Hornseth, Megan L.; Walpole, Aaron A.; Walton, Lyle R.; Bowman, Jeff; Ray, Justina C.; Fortin, Marie-Josée; Murray, Dennis L.

    2014-01-01

    Peripheral populations often experience more extreme environmental conditions than those in the centre of a species' range. Such extreme conditions include habitat loss, defined as a reduction in the amount of suitable habitat, as well as habitat fragmentation, which involves the breaking apart of habitat independent of habitat loss. The 'threshold hypothesis' predicts that organisms will be more affected by habitat fragmentation when the amount of habitat on the landscape is scarce (i.e., le...

  12. Epitaxial Ni films, e-beam nano-patterning and BMR

    Science.gov (United States)

    Lukaszew, R. Alejandra; Zhang, Zhengdong; Pearson, Dave; Zambano, Antonio

    2004-05-01

    We have attempted to clarify possible domain-wall processes present in the recently reported large ballistic magnetoresistance effects in nano-contacts. To that effect we have used e-beam lithography applied to epitaxial Ni films to fabricate nano-bridges in more controlled geometry than electrochemical deposition. Our preliminary results indicate that magnetic domains do play a role in the magneto-resistance of these nano-bridges but the order of magnitude of the observed effect is considerably smaller than the reported observations in electrochemically prepared nano-contacts.

  13. Epitaxial Ni films, e-beam nano-patterning and BMR

    International Nuclear Information System (INIS)

    Lukaszew, R.A.; Zhang Zhengdong; Pearson, Dave; Zambano, Antonio

    2004-01-01

    We have attempted to clarify possible domain-wall processes present in the recently reported large ballistic magnetoresistance effects in nano-contacts. To that effect we have used e-beam lithography applied to epitaxial Ni films to fabricate nano-bridges in more controlled geometry than electrochemical deposition. Our preliminary results indicate that magnetic domains do play a role in the magneto-resistance of these nano-bridges but the order of magnitude of the observed effect is considerably smaller than the reported observations in electrochemically prepared nano-contacts

  14. Efficacy and safety of 5% minoxidil topical foam in male pattern hair loss treatment and patient satisfaction.

    Science.gov (United States)

    Hasanzadeh, Hournaz; Nasrollahi, Saman Ahmad; Halavati, Nader; Saberi, Maryam; Firooz, Alireza

    2016-09-01

    Male pattern hair loss is widespread around the world. Its prevalence indicates the importance of finding the best treatment modalities. This study evaluates the efficacy and safety of minoxidil 5% topical foam in male pattern hair loss treatment and patient satisfaction. This study was a before-and-after trial on 17 male patients with male pattern hair loss. Subjects were instructed to apply one capful (1 ml) of minoxidil 5% topical foam on the scalp daily for 6 months. Efficacy was assessed through hair counts, subject assessment, and global photographic review. Seventeen male volunteers were recruited, and three volunteers were withdrawn; 14 participated in the trial for 16 weeks, and 12 continued up to 24 weeks. The average hair count with a camera at week 16 (181.87 ± 52.42) and week 24 (194.58 ± 62.82) and with an eye count at week 16 (62.57 ± 15.28) and week 24 (69.91 ± 15.61) increased significantly compared to the baseline after intervention. This study confirmed that minoxidil 5% topical foam is a safe and effective treatment for MPHL. The effect of it is evident after 24 weeks of use.

  15. Superresolution beams

    CSIR Research Space (South Africa)

    Ngcobo, S

    2012-07-01

    Full Text Available positions of p zeros of intensity distributions on the Gaussian beam, resulting to a generation of TEMp0 beams where there are minimum losses. The LGBs are well-known family of exact orthogonal solutions of free-space paraxial wave equation in cylindrical...

  16. Resolution Improvement and Pattern Generator Development for theMaskless Micro-Ion-Beam Reduction Lithography System

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Ximan [Univ. of California, Berkeley, CA (United States)

    2006-05-18

    strategies have been studied. The dependence of the throughput with the exposure field size and the speed of the mechanical stage has been investigated. In order to perform maskless lithography, different micro-fabricated pattern generators have been developed for the MMRL system. Ion beamlet switching has been successfully demonstrated on the MMRL system. A positive bias voltage around 10 volts is sufficient to switch off the ion current on the micro-fabricated pattern generators. Some unexpected problems, such as the high-energy secondary electron radiations, have been discovered during the experimental investigation. Thermal and structural analysis indicates that the aperture displacement error induced by thermal expansion can satisfy the 3δ CD requirement for lithography nodes down to 25 nm. The cross-talking effect near the surface and inside the apertures of the pattern generator has been simulated in a 3-D ray-tracing code. New pattern generator design has been proposed to reduce the cross-talking effect. In order to eliminate the surface charging effect caused by the secondary electrons, a new beam-switching scheme in which the switching electrodes are immersed in the plasma has been demonstrated on a mechanically fabricated pattern generator.

  17. Effect of Gamma Radiation and Electron Beam on Microbiological Quality and Protein Patterns of 4 Selected Beans

    International Nuclear Information System (INIS)

    Chookaew, S.; Eamsir, J.; Pewlong, W.; Sajjabut, S.

    2014-01-01

    The aim of the present study was to evaluate the effect of gamma ray and electron beam on microbiological quality and protein pattern of four selected beans: mung beans, soy beans, peanuts and black beans. All beans samples were exposed to irradiation at doses of 0, 0.5, 1, and 2 kGy before evaluated for their microbiological quality using AOAC method and protein analysis by gel electrophoresis. Results showed that the amount of bacteria, yeast and mold of irradiated mung beans and peanuts were reduced, whereas these microbiological quality values remained relatively the same for irradiated soy beans and black beans compared to non-irradiated samples. In terms of protein analysis, the protein patterns of the irradiated beans were of the same quality as the non-irradiated samples. To further tested the effect of irradiation on the bean's protein at higher doses, all four selected beans were exposed to gamma ray at 10, 50, 100, 150 and 200 kGy. We found that the protein patterns of mung beans, peanuts and black beans were altered at doses above 50 kGy.

  18. Focused-ion-beam overlay-patterning of three-dimensional diamond structures for advanced single-photon properties

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Qianqing; Liu, Dongqi; Liu, Gangqin; Chang, Yanchun; Li, Wuxia, E-mail: liwuxia@aphy.iphy.ac.cn, E-mail: czgu@aphy.iphy.ac.cn [Beijing National Laboratory of Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China); Pan, Xinyu; Gu, Changzhi, E-mail: liwuxia@aphy.iphy.ac.cn, E-mail: czgu@aphy.iphy.ac.cn [Beijing National Laboratory of Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China); Collaborative Innovation Center of Quantum Matter, Beijing 100190 (China)

    2014-07-28

    Sources of single photons are of fundamental importance in many applications as to provide quantum states for quantum communication and quantum information processing. Color centers in diamond are prominent candidates to generate and manipulate quantum states of light, even at room temperature. However, the efficiency of photon collection of the color centers in bulk diamond is greatly reduced by refraction at the diamond/air interface. To address this issue, diamond structuring has been investigated by various methods. Among them, focused-ion-beam (FIB) direct patterning has been recognized as the most favorable technique. But it has been noted that diamond tends to present significant challenges in FIB milling, e.g., the susceptibility of forming charging related artifacts and topographical features. In this work, periodically-positioned-rings and overlay patterning with stagger-superimposed-rings were proposed to alleviate some problems encountered in FIB milling of diamond, for improved surface morphology and shape control. Cross-scale network and uniform nanostructure arrays have been achieved in single crystalline diamond substrates. High quality diamond solid immersion lens and nanopillars were sculptured with a nitrogen-vacancy center buried at the desired position. Compared with the film counterpart, an enhancement of about ten folds in single photon collection efficiency was achieved with greatly improved signal to noise ratio. All these results indicate that FIB milling through over-lay patterning could be an effective approach to fabricate diamond structures, potentially for quantum information studies.

  19. Loss-of-Function Sodium Channel Mutations in Infancy A Pattern Unfolds

    NARCIS (Netherlands)

    Chockalingam, Priya; Wilde, Arthur A. M.

    2012-01-01

    The role of channelopathies in the pathogenesis of sudden cardiac death (SCD) in patients with structurally normal hearts is a rapidly evolving story.(1) Many ion channels are involved, including loss-of-function sodium channelopathies of which the phenotypic spectrum ranges from lethal arrhythmias

  20. In situ patterning of organic molecules in aqueous solutions using an inverted electron-beam lithography system

    Science.gov (United States)

    Miyazako, Hiroki; Ishihara, Kazuhiko; Mabuchi, Kunihiko; Hoshino, Takayuki

    2016-06-01

    A method for in situ controlling the detachment and deposition of organic molecules such as sugars and biocompatible polymers in aqueous solutions by electron-beam (EB) scan is proposed and evaluated. It was demonstrated that EB irradiation could detach 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers from a silicon nitride membrane. Moreover, organic molecules such as cationic polymers and sugars could be deposited on the membrane by EB irradiation. Spatial distributions of scattered electrons were numerically simulated, and acceleration voltage dependences of the detachment and deposition phenomena were experimentally measured. The simulations and experimental results suggest that the detachment of MPC polymers is mainly due to electrical effects of primary electrons, and that the deposition of organic molecules is mainly due to chemical reactions induced by primary electrons. In view of these findings, the proposed method can be applied to in situ and nanoscale patterning such as the fabrication of cell scaffolds.

  1. Electron-beam patterned self-assembled monolayers as templates for Cu electrodeposition and lift-off

    Directory of Open Access Journals (Sweden)

    Zhe She

    2012-02-01

    Full Text Available Self-assembled monolayers (SAMs of 4'-methylbiphenyl-4-thiol (MBP0 adsorbed on polycrystalline gold substrates served as templates to control electrochemical deposition of Cu structures from acidic solution, and enabled the subsequent lift-off of the metal structures by attachment to epoxy glue. By exploiting the negative-resist behaviour of MBP0, the SAM was patterned by means of electron-beam lithography. For high deposition contrast a two-step procedure was employed involving a nucleation phase around −0.7 V versus Cu2+/Cu and a growth phase at around −0.35 V versus Cu2+/Cu. Structures with features down to 100 nm were deposited and transferred with high fidelity. By using substrates with different surface morphologies, AFM measurements revealed that the roughness of the substrate is a crucial factor but not the only one determining the roughness of the copper surface that is exposed after lift-off.

  2. Memory resistive switching in CeO2-based film microstructures patterned by a focused ion beam

    DEFF Research Database (Denmark)

    Velichko, A.; Boriskov, P.; Grishin, A.

    2014-01-01

    ) with insulating properties and a semiconducting ormetallic lowresistance state (ON) with resistance ratios up to 104. The influence of micro-scaling and defects formed at the cell boundaries during etching on its electrical characteristics has been analyzed. The appearance of a switching channel at the moment......Heteroepitaxial CeO2 (80 nm)/La0.5Sr0.5CoO3 (500 nm) film structure has been pulsed laser deposited on a sapphire substrate. The Ag/CeO2 microjunctions patterned by a focused ion beam on a La0.5Sr0.5CoO3 film exhibit reproducible reversible switching between a high resistance state (OFF...... of the electrical forming, responsible for the memory effect, has been proved, along with a mechanism of a self-healing electrical breakdown. © 2014 Elsevier B.V. All rights reserved....

  3. Blanket Module Boil-Off Times during a Loss-of-Coolant Accident - Case 0: with Beam Shutdown only

    International Nuclear Information System (INIS)

    Hamm, L.L.

    1998-01-01

    This report is one of a series of reports that document LBLOCA analyses for the Accelerator Production of Tritium primary blanket Heat Removal system. This report documents the analysis results of a LBLOCA where the accelerator beam is shut off without primary pump trips and neither the RHR nor the cavity flood systems operation

  4. Can preferred atmospheric circulation patterns over the North-Atlantic-Eurasian region be associated with arctic sea ice loss?

    Science.gov (United States)

    Crasemann, Berit; Handorf, Dörthe; Jaiser, Ralf; Dethloff, Klaus; Nakamura, Tetsu; Ukita, Jinro; Yamazaki, Koji

    2017-12-01

    In the framework of atmospheric circulation regimes, we study whether the recent Arctic sea ice loss and Arctic Amplification are associated with changes in the frequency of occurrence of preferred atmospheric circulation patterns during the extended winter season from December to March. To determine regimes we applied a cluster analysis to sea-level pressure fields from reanalysis data and output from an atmospheric general circulation model. The specific set up of the two analyzed model simulations for low and high ice conditions allows for attributing differences between the simulations to the prescribed sea ice changes only. The reanalysis data revealed two circulation patterns that occur more frequently for low Arctic sea ice conditions: a Scandinavian blocking in December and January and a negative North Atlantic Oscillation pattern in February and March. An analysis of related patterns of synoptic-scale activity and 2 m temperatures provides a synoptic interpretation of the corresponding large-scale regimes. The regimes that occur more frequently for low sea ice conditions are resembled reasonably well by the model simulations. Based on those results we conclude that the detected changes in the frequency of occurrence of large-scale circulation patterns can be associated with changes in Arctic sea ice conditions.

  5. Controversy: Is there a role for adjuvants in the management of male pattern hair loss?

    Directory of Open Access Journals (Sweden)

    Rajendrasingh J Rajput

    2010-01-01

    Full Text Available Patients with hair loss are seeking treatment at a younger age and during earlier stages. Not all need hair transplants. Because of the lack of assured management and the fear of side-effects, patients are turning to ineffective alternative remedies from self-claimed experts. In this report, we discuss the available treatment options and how best they can be used in combination to produce satisfactory results. The traditional approach consists of administration of drugs such as minoxidil and finasteride. We propose a hypothesis that nutritional supplements, 2% ketoconazole shampoo and low-level laser therapy along with finasteride 1 mg used once in 3 days with 2% minoxidil used everyday, given in a cyclical medicine program may be useful to manage hair loss and achieve new hair growth. The scientific rationale for such an approach is explained. The need for further studies to establish the efficacy of the regime is stressed upon.

  6. Maxillofacial trauma patterns associated with external auditory canal fractures: Cone beam computed tomography analysis.

    Science.gov (United States)

    Ali, Ibrahim K; Sansare, Kaustubh; Karjodkar, Freny R; Salve, Prashant; Vanga, Kavita; Pawar, Ajinkya M

    2017-08-01

    There is a paucity of literature on external auditory canal (EAC) fractures secondary to maxillofacial trauma, with most of the literature on EAC fractures consisting of isolated case reports. To the authors' best knowledge, this is the first study to use cone beam computed tomography to evaluate the EAC region. The aim of this study was to assess the prevalence of external auditory canal (EAC) fracture following maxillofacial trauma and to evaluate the association between EAC fracture and other maxillofacial fractures and the region of trauma. One hundred patients were prospectively evaluated over 6 months from February to August 2016. The patients were referred for CBCT regarding temporomandibular joint or condylar fractures following maxillofacial trauma. Two observers (both experienced radiologists) assessed the EAC and associated fractures in the maxillofacial region. External auditory canal (EAC) fracture was confirmed in 32% of the patients. Of the EAC fractures, 68.75% and 31.25% were associated with mandibular fractures and non-mandibular fractures, respectively. Of the EAC fractures, 68.75% were single fractures and 31.25% of patients had multiple comminuted fractures. Significant association was observed on cross-tabulation of the fractured region and region of trauma with the presence of EAC fracture using chi-square test. External auditory canal (EAC) fracture is associated with maxillofacial fractures with increased incidence in mandibular fractures compared to non-mandibular fractures. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  7. Location, Timing, and Social Structure Patterns Related to Physical Activity Participation in Weight Loss Programs

    Science.gov (United States)

    Gay, Jennifer L.; Trevarthen, Grace

    2013-01-01

    Less than half of the adults in the United States meet national guidelines for physical activity. Physical activity programs can induce short-term improvements in physical activity. To develop effective interventions, researchers and practitioners should consider the timing, location, and social structure patterns of participants. Using a pretest,…

  8. Pattern of hearing loss in a rat model of cochlear implantation trauma.

    Science.gov (United States)

    Eshraghi, Adrien A; Polak, Marek; He, Jiao; Telischi, Fred F; Balkany, Thomas J; Van De Water, Thomas R

    2005-05-01

    Trauma caused by cochlear implant electrode insertion is attributable to the combination of direct physical trauma and the delayed cell death of oxidative stress-injured auditory sensory cells. Histologic evaluation of cochlear implant electrode trauma has demonstrated that the extent of sensory cell losses is proportional to the degree of injury. However, the impact of delayed oxidative stress within injured cochlear tissues and the progressive loss of injured hair cells by way of apoptosis are at present unknown. Laboratory rats were evaluated for hearing acuity before and after electrode insertion, before and after round window membrane incision only. Hearing was measured before trauma or incision and over the next 7 days. Objective measurements of hearing function were distortion products of otoacoustic emissions (DPOAEs) in the frequency range of 2 to 32 kHz and tone-burst (i.e., 4-32 kHz) evoked auditory brain stem responses (ABRs). For the experimental cochleae, there were progressive increases in ABR thresholds and decreases in ABR amplitudes. The amplitude of the DPOAEs in the experimental cochleae also showed progressive decreases. For the contralateral control and round window membrane surgical control ears, there were no significant changes in either DPOAE or ABR thresholds. These results document a progressive loss of hearing acuity postimplantation and strongly suggest that electrode insertion trauma generated oxidative stress within injured cochlear tissues.

  9. The zinc-loss effect and mobility enhancement of DUV-patterned sol–gel IGZO thin-film transistors

    Science.gov (United States)

    Wang, Kuan-Hsun; Zan, Hsiao-Wen; Soppera, Olivier

    2018-03-01

    We investigate the composition of the DUV-patterned sol–gel indium gallium zinc oxide (IGZO) thin-film transistors (TFTs) and observe a significant zinc loss effect during developing when the DUV exposure is insufficient. The zinc loss, however, is beneficial for increasing the mobility. Reducing zinc to indium composition ratio from 0.5 to 0.02 can effectively increase mobility from 0.27 to 7.30 cm2 V–1 s–1 when the gallium to indium ratio is fixed as 0.25 and the post annealing process is fixed as 300 °C for 2 h. On the other hand, an IGO TFT fails to deliver a uniform film and a reproducible TFT performance, revealing the critical role of zinc in forming homogeneous IGZO TFTs.

  10. External beam irradiation for retinoblastoma: patterns of failure and dose-response analysis

    International Nuclear Information System (INIS)

    Foote, R.L.; Garretson, B.R.; Schomberg, P.J.; Buskirk, S.J.; Robertson, D.M.; Earle, J.D.

    1989-01-01

    Eighteen children with retinoblastoma (25 eyes) were treated with external beam radiation at the Mayo Clinic between January 1977 and January 1987; 15 eyes were in groups I to III and 10 were in groups IV and V. The median number of tumors per eye was 3. Radiation therapy consisted of 4- or 6-MV photons. Doses varied from 39 to 51 Gy in 1.8- to 3.0-Gy fractions. Fourteen eyes were treated through lateral fields by anterior segment-sparing techniques, and 11 eyes were treated by an anterior approach with no attempt at anterior segment sparing. All patients survived (median follow-up, 31.5 months). Cataracts developed in five eyes at a median of 23 months, four in eyes treated with anterior segment-sparing techniques. Of the 15 group I to III eyes, 6 required additional treatment; 4 were salvaged with cryotherapy or photocoagulation and 2 were enucleated. Of the 10 group IV and V eyes, 8 required additional treatment; 4 were salvaged with cryotherapy or photocoagulation, 1 with persistent disease is being followed closely, and 3 were enucleated. Ten (71%) of the 14 eyes treated with anterior segment-sparing techniques required additional treatment. Four (36%) of the 11 eyes treated with an anterior approach required additional treatment. Ninety percent of the tumors 10 disc diameters or smaller (1 disc diameter = 1.6 mm) were controlled independently of dose and fractionation used when they were not in the low-dose area of the anterior retina of an eye treated with an anterior segment-sparing technique. We find that use of lateral, anterior segment-sparing techniques has a high risk of anterior retinal tumor development and cataract formation and should be abandoned in favor of techniques that treat the entire retina

  11. External beam irradiation for retinoblastoma: patterns of failure and dose-response analysis

    Energy Technology Data Exchange (ETDEWEB)

    Foote, R.L.; Garretson, B.R.; Schomberg, P.J.; Buskirk, S.J.; Robertson, D.M.; Earle, J.D.

    1989-03-01

    Eighteen children with retinoblastoma (25 eyes) were treated with external beam radiation at the Mayo Clinic between January 1977 and January 1987; 15 eyes were in groups I to III and 10 were in groups IV and V. The median number of tumors per eye was 3. Radiation therapy consisted of 4- or 6-MV photons. Doses varied from 39 to 51 Gy in 1.8- to 3.0-Gy fractions. Fourteen eyes were treated through lateral fields by anterior segment-sparing techniques, and 11 eyes were treated by an anterior approach with no attempt at anterior segment sparing. All patients survived (median follow-up, 31.5 months). Cataracts developed in five eyes at a median of 23 months, four in eyes treated with anterior segment-sparing techniques. Of the 15 group I to III eyes, 6 required additional treatment; 4 were salvaged with cryotherapy or photocoagulation and 2 were enucleated. Of the 10 group IV and V eyes, 8 required additional treatment; 4 were salvaged with cryotherapy or photocoagulation, 1 with persistent disease is being followed closely, and 3 were enucleated. Ten (71%) of the 14 eyes treated with anterior segment-sparing techniques required additional treatment. Four (36%) of the 11 eyes treated with an anterior approach required additional treatment. Ninety percent of the tumors 10 disc diameters or smaller (1 disc diameter = 1.6 mm) were controlled independently of dose and fractionation used when they were not in the low-dose area of the anterior retina of an eye treated with an anterior segment-sparing technique. We find that use of lateral, anterior segment-sparing techniques has a high risk of anterior retinal tumor development and cataract formation and should be abandoned in favor of techniques that treat the entire retina.

  12. Patterning, Characterization and Chemical Sensing Applications of Graphene Nanoribbon Arrays Down to 5 nm Using Helium Ion Beam Lithography

    Science.gov (United States)

    Abbas, Ahmad; Liu, Gang; Liu, Bilu; Zhang, Luyao; Liu, He; Ohlberg, Douglas; Wu, Wei; Zhou, Chongwu

    2014-03-01

    Bandgap engineering of graphene is an essential step towards employing graphene in electronic and sensing applications. Recently, graphene nanoribbons (GNRs) were used to create a bandgap in graphene and function as a semiconducting switch. Although GNRs with widths of problems like GNR alignment, width control, uniformity, high aspect ratios, and edge roughness must be resolved in order to introduce GNRs as a robust alternative technology. Here we report patterning, characterization and superior chemical sensing of ultra-narrow aligned GNR arrays down to 5 nm width using helium ion beam lithography (HIBL) for the first time. The patterned GNR arrays possess narrow and adjustable widths, high aspect ratios, and relatively high quality. Field-effect transistors were fabricated on such GNR arrays and temperature-dependent transport measurements show the thermally activated carrier transport in the GNR array structure. Furthermore, we have demonstrated exceptional NO2 gas sensitivity of the 5 nm GNR array devices down to ppb levels. The results show the potential of HIBL fabricated GNRs for the electronic and sensing applications. We would like to thank HP labs for the use of helium ion microscope. We thank Professor Kang L. Wang and Stephen B. Cronin for help with some of the experiments. We acknowledge the office of Naval Research for financial support.

  13. Monte Carlo studies of the radiation fields in the linac coherent light source undulators and of the corresponding signals in the Cerenkov beam loss monitors

    International Nuclear Information System (INIS)

    Santana Leitner, Mario; Fasso, Alberto; Fisher, Alan S.; Nuhn, Heinz D.; Dooling, Jeffrey C.; Berg, William; Yang, Bin. X.

    2010-01-01

    In 2009 the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Center started free electron laser (FEL) operation. In order to continue to produce the bright and short-pulsed x-ray laser demanded by FEL scientists, this pioneer hard x-ray FEL requires a perfectly tailored magnetic field at the undulators, so that the photons generated at the electron wiggling path interact at the right phase with the electron beam. In such a precise system, small (>0.01%) radiation-induced alterations of the magnetic field in the permanent magnets could affect FEL performance. This paper describes the simulation studies of radiation fields in permanent magnets and the expected signal in the detectors. The transport of particles from the radiation sources (i.e. diagnostic insert) to the undulator magnets and to the beam loss monitors (BLM) was simulated with the intra nuclear cascade codes FLUKA and MARS15. In order to accurately reproduce the optics of LCLS, lattice capabilities and magnetic fields were enabled in FLUKA and betatron oscillations were validated against reference data. All electron events entering the BLMs were printed in data files. The paper also introduces the Radioactive Ion Beam Optimizer (RIBO) Monte Carlo 3-D code, which was used to read from the event files, to compute Cerenkov production and then to simulate the optical coupling of the BLM detectors, accounting for the transmission of light through the quartz. (author)

  14. Weight Loss Associated With Different Patterns of Self-Monitoring Using the Mobile Phone App My Meal Mate.

    Science.gov (United States)

    Carter, Michelle C; Burley, Victoria J; Cade, Janet E

    2017-02-02

    Obesity is a major global public health issue due to its association with a number of serious chronic illnesses and its high economic burden to health care providers. Self-monitoring of diet has been consistently linked to weight loss. However, there is limited evidence about how frequently individuals need to monitor their diet for optimal weight loss. The aim of this paper is to describe app usage frequency and pattern in the mobile phone arm of a previously conducted randomized controlled trial. The relationship between frequency and pattern of electronic dietary self-monitoring and weight loss is also investigated. A randomized pilot trial comparing three methods of self-monitoring (mobile phone app, paper diary, Web-based) was previously conducted. Trial duration was 6 months. The mobile phone app My Meal Mate features an electronic food diary and encourages users to self-monitor their dietary intake. All food consumption data were automatically uploaded with a time and date stamp. Post hoc regression analysis of app usage patterns was undertaken in the My Meal Mate group (n=43; female: 77%, 33/43; white: 100%, 43/43; age: mean 41, SD 9 years; body mass index: mean 34, SD 4 kg/m 2 ) to explore the relationship between frequency and pattern of electronic dietary self-monitoring and weight loss. Baseline characteristics of participants were also investigated to identify any potential predictors of dietary self-monitoring. Regression analysis showed that those in the highest frequency-of-use category (recorded ≥129 days on the mobile phone app) had a -6.4 kg (95% CI -10.0 to -2.9) lower follow-up weight (adjusted for baseline weight) than those in the lowest frequency-of-use category (recorded ≤42 days; Pweight loss than other patterns of electronic self-monitoring (ie, monitoring over the short or moderate term and stopping and consistently monitoring over consecutive days). Participant characteristics such as age, baseline weight, sex, ethnicity

  15. Ion beam induced surface pattern formation and stable travelling wave solutions.

    Science.gov (United States)

    Numazawa, Satoshi; Smith, Roger

    2013-03-06

    The formation of ripple structures on ion bombarded semiconductor surfaces is examined theoretically. Previous models are discussed and a new nonlinear model is formulated, based on the infinitesimal local atomic relocation induced by elastic nuclear collisions in the early stages of collision cascades and an associated density change in the near surface region. Within this framework ripple structures are shown to form without the necessity to invoke surface diffusion or large sputtering as important mechanisms. The model can also be extended to the case where sputtering is important, and it is shown that in this case certain 'magic' angles can occur at which the ripple patterns are most clearly defined. The results are in very good agreement with experimental observations.

  16. An analysis of the inheritance pattern of an adult-onset hearing loss in Border Collie dogs.

    Science.gov (United States)

    Schmutz, Sheila M

    2014-01-01

    During routine diagnostic BAER testing of dogs of various breeds for private owners at the Western College of Veterinary Medicine in Saskatoon, it became evident that some individual dogs developed hearing loss as adults. Although inherited congenital deafness has been widely reported in dogs, this type of deafness had not. Special clinics were set up to screen working Border Collies at herding competitions. To determine the typical age that geriatric deafness might be expected, retired dogs were also recruited. Five of the 10 Border Collies 12 years of age or older had hearing loss (1 bilaterally deaf and 4 had reduced hearing). The adult onset deafness which exhibited in three families, did not usually occur until 5 years of age, too young to be geriatric deafness. This adult onset deafness fits an autosomal dominant pattern of inheritance. Several of these dogs had been BAER tested at younger ages with no sign of deafness. The deaf dogs were not associated with either gender. A survey was developed which was completed by the dog owners, that indicated that the hearing loss was gradual, not sudden. In addition, some family studies were conducted. Dogs at 5 years of age were often in the prime of their herding careers and then did not respond appropriately to distant commands. This type of deafness is important to dog owners but is also a potential medical model for some forms of hearing loss in humans. This report also suggests that geriatric hearing loss is common in dogs older than 12 years.

  17. Global patterns of extreme drought-induced loss in land primary production: Identifying ecological extremes from rain-use efficiency.

    Science.gov (United States)

    Du, Ling; Mikle, Nathaniel; Zou, Zhenhua; Huang, Yuanyuan; Shi, Zheng; Jiang, Lifen; McCarthy, Heather R; Liang, Junyi; Luo, Yiqi

    2018-02-14

    Quantifying the ecological patterns of loss of ecosystem function in extreme drought is important to understand the carbon exchange between the land and atmosphere. Rain-use efficiency [RUE; gross primary production (GPP)/precipitation] acts as a typical indicator of ecosystem function. In this study, a novel method based on maximum rain-use efficiency (RUE max ) was developed to detect losses of ecosystem function globally. Three global GPP datasets from the MODIS remote sensing data (MOD17), ground upscaling FLUXNET observations (MPI-BGC), and process-based model simulations (BESS), and a global gridded precipitation product (CRU) were used to develop annual global RUE datasets for 2001-2011. Large, well-known extreme drought events were detected, e.g. 2003 drought in Europe, 2002 and 2011 drought in the U.S., and 2010 drought in Russia. Our results show that extreme drought-induced loss of ecosystem function could impact 0.9% ± 0.1% of earth's vegetated land per year and was mainly distributed in semi-arid regions. The reduced carbon uptake caused by functional loss (0.14 ± 0.03 PgC/yr) could explain >70% of the interannual variation in GPP in drought-affected areas (p ≤ 0.001). Our results highlight the impact of ecosystem function loss in semi-arid regions with increasing precipitation variability and dry land expansion expected in the future. Copyright © 2018 Elsevier B.V. All rights reserved.

  18. Loss-pattern identification in near-real-time accounting systems

    International Nuclear Information System (INIS)

    Argentesi, F.; Hafer, J.F.; Markin, J.T.; Shipley, J.P.

    1982-01-01

    To maximize the benefits from an advanced safeguards technique such as near-real-time accounting (NRTA), sophisticated methods of analyzing sequential materials accounting data are necessary. The methods must be capable of controlling the overall false-alarm rate while assuring good power of detection against all possible diversion scenarios. A method drawn from the field of pattern recognition and related to the alarm-sequence chart appears to be promising. Power curves based on Monte Carlo calculations illustrate the improvements over more conventional methods. 3 figures, 2 tables

  19. Author Correction: Global patterns in mangrove soil carbon stocks and losses

    Science.gov (United States)

    Atwood, Trisha B.; Connolly, Rod M.; Almahasheer, Hanan; Carnell, Paul E.; Duarte, Carlos M.; Lewis, Carolyn J. Ewers; Irigoien, Xabier; Kelleway, Jeffrey J.; Lavery, Paul S.; Macreadie, Peter I.; Serrano, Oscar; Sanders, Christian J.; Santos, Isaac; Steven, Andrew D. L.; Lovelock, Catherine E.

    2017-11-01

    In the version of this Article originally published, the potential carbon loss from soils as a result of mangrove deforestation was incorrectly given as `2.0-75 Tg C yr-1'; this should have read `2-8 Tg C yr-1'. The corresponding emissions were incorrectly given as ` 7.3-275 Tg of CO2e'; this should have read ` 7-29 Tg of CO2e'. The corresponding percentage equivalent of these emissions compared with those from global terrestrial deforestation was incorrectly given as `0.2-6%'; this should have read `0.6-2.4%'. These errors have now been corrected in all versions of the Article.

  20. Cerebral blood flow studied by 133Xe inhalation technique in parkinsonism: loss of hyperfrontal pattern

    International Nuclear Information System (INIS)

    Bes, A.; Gueell, A.; Fabre, N.; Dupui, P.; Victor, G.; Geraud, G.

    1983-01-01

    Cerebral blood flow (grey matter flow) in parkinsonism requires further investigation. The noninvasive method of 133 Xe inhalation permits study of larger numbers of subjects than previously used invasive techniques such as the intracarotid 133 Xe injection method. Measurements were made in this laboratory in 30 subjects having Parkinson's disease. Mean hemispheric blood flow (F1) values were 70.4 +/- 9.3 ml/100 g/min, compared to 76.3 for a group of age-matched normal subjects, which is a decrease of -7.8%. The most striking difference was the loss of the hyperfrontal distribution in parkinsonism. The prefrontal F1 values were only 1.8% greater than the hemisphere grey matter flow, compared with 8.5% in controls of a similar age group

  1. Prevalence and pattern of misconceptions about semen loss and sexual prowess among male medical interns

    Directory of Open Access Journals (Sweden)

    Ajish G Mangot

    2017-01-01

    Full Text Available Introduction: Sexual misconceptions have been around in India for a very long time. Growing liberal attitudes toward sex and sexual permissiveness can be expected to occur in the context of improved sexual knowledge among people. However, sexual myths continue to remain rampant. Therefore, the present study was planned with the aim to assess the level of sexual misconceptions regarding semen loss prevalent among male medical interns. Participants and Methods: This was a cross-sectional study among unmarried male medical students doing an internship. Eighty-one interns were recruited after fulfilling predecided inclusion/exclusion criteria and were asked to complete a specially made questionnaire to assess their sexual beliefs anonymously in complete privacy. Responses were analyzed using frequency distribution. Results: Seventy-nine percent of the participants believed that loss of semen can lead to reduction in the size of the penis, while 44.44% (n = 36 believed that it leads to sexual weakness, 56.8% (n = 46 believed it can lead to physical weakness, and 56.8% (n = 46 believed that excess masturbation can decrease sexual prowess. Discussion: This study helps bring to light the prevalence of sexual misconceptions among medical interns in spite of reaching a stage where they are expected to have sound conceptual, theoretical, and practical knowledge about sexual health and wellbeing. There is a dearth of national and international studies exploring the sociocultural aspects of sexuality specifically among medical students. The findings from this study are expected to stimulate researchers and academicians into further exploring the aspect of sexuality among the young medical fraternity.

  2. Loss of pattern separation performance in schizophrenia suggests dentate gyrus dysfunction.

    Science.gov (United States)

    Das, Tanusree; Ivleva, Elena I; Wagner, Anthony D; Stark, Craig E L; Tamminga, Carol A

    2014-10-01

    Motivated by evidence that the dentate gyrus differentially mediates the pattern separation (PS) component of declarative memory function and that dentate gyrus harbors molecular and cellular pathologies in schizophrenia, we examined whether PS performance is altered in volunteers with schizophrenia (SZV) relative to healthy volunteers (HV). In groups of well-characterized SZV (n=14) and HV (n=15), we contrasted performance on the Behavioral Pattern Separation (BPS) Task, acquiring two outcome measures, a PS parameter and a Recognition Memory (RM) parameter, as well as specific recognition data by stimulus type. The SZVs showed a significant decrement in PS performance relative to HV (mean ± SEM, SZV: 3.1 ± 2.7%; HV: 17.1 ± 5.8%; p=0.039, d'=0.86); whereas SZV and HV did not significantly differ in RM performance (SZV: 50.1 ± 8.1%; HV: 59.3 ± 5.5%; p=0.350, d'=0.36). Moreover, the SZVs showed a selective defect in correctly identifying similar lure items (SZV: 24.0 ± 3.7%; HV: 41.2 ± 4.6%; pfeature that could contribute to declarative memory impairment in the disorder and possibly to psychosis, a conclusion consistent with the considerable molecular pathology in the dentate gyrus in schizophrenia. Copyright © 2014 Elsevier B.V. All rights reserved.

  3. The origin and loss of periodic patterning in the turtle shell.

    Science.gov (United States)

    Moustakas-Verho, Jacqueline E; Zimm, Roland; Cebra-Thomas, Judith; Lempiäinen, Netta K; Kallonen, Aki; Mitchell, Katherine L; Hämäläinen, Keijo; Salazar-Ciudad, Isaac; Jernvall, Jukka; Gilbert, Scott F

    2014-08-01

    The origin of the turtle shell over 200 million years ago greatly modified the amniote body plan, and the morphological plasticity of the shell has promoted the adaptive radiation of turtles. The shell, comprising a dorsal carapace and a ventral plastron, is a layered structure formed by basal endochondral axial skeletal elements (ribs, vertebrae) and plates of bone, which are overlain by keratinous ectodermal scutes. Studies of turtle development have mostly focused on the bones of the shell; however, the genetic regulation of the epidermal scutes has not been investigated. Here, we show that scutes develop from an array of patterned placodes and that these placodes are absent from a soft-shelled turtle in which scutes were lost secondarily. Experimentally inhibiting Shh, Bmp or Fgf signaling results in the disruption of the placodal pattern. Finally, a computational model is used to show how two coupled reaction-diffusion systems reproduce both natural and abnormal variation in turtle scutes. Taken together, these placodal signaling centers are likely to represent developmental modules that are responsible for the evolution of scutes in turtles, and the regulation of these centers has allowed for the diversification of the turtle shell. © 2014. Published by The Company of Biologists Ltd.

  4. Developing and setting up optical methods to study the speckle patterns created by optical beam smoothing

    International Nuclear Information System (INIS)

    Surville, J.

    2005-12-01

    We have developed three main optical methods to study the speckles generated by a smoothed laser source. The first method addresses the measurement of the temporal and spatial correlation functions of the source, with a modified Michelson interferometer. The second one is a pump-probe technique created to shoot a picture of a speckle pattern generated at a set time. And the third one is an evolution of the second method dedicated to time-frequency coding, thanks to a frequency chirped probe pulse. Thus, the speckles can be followed in time and their motion can be described. According to these three methods, the average size and duration of the speckles can be measured. It is also possible to measure the size and the duration of each of them and mostly their velocity in a given direction. All the results obtained have been confronted to the different existing theories. We show that the statistical distributions of the measured speckles'size and speckles'intensity agree satisfactorily with theoretical values

  5. Meal pattern alterations associated with intermittent fasting for weight loss are normalized after high-fat diet re-feeding.

    Science.gov (United States)

    Gotthardt, Juliet D; Bello, Nicholas T

    2017-05-15

    Alternate day, intermittent fasting (IMF) can be an effective weight loss strategy. However, the effects of IMF on eating behaviors are not well characterized. We investigated the acute and residual effects of IMF for weight loss on meal patterns in adult obese male C57BL/6 mice. After 8weeks of ad libitum high-fat diet to induce diet-induced obesity (DIO), mice were either continued on ad libitum high-fat diet (HFD) or placed on one of 5 diet strategies for weight loss: IMF of high-fat diet (IMF-HFD), pair-fed to IMF-HFD group (PF-HFD), ad libitum low-fat diet (LFD), IMF of low-fat diet (IMF-LFD), or pair-fed to IMF-LFD group (PF-LFD). After the 4-week diet period, all groups were refed the high-fat diet for 6weeks. By the end of the diet period, all 5 groups had lost weight compared with HFD group, but after 6weeks of HFD re-feeding all groups had similar body weights. On (Day 2) of the diet period, IMF-HFD had greater first meal size and faster eating rate compared with HFD. Also, first meal duration was greater in LFD and IMF-LFD compared with HFD. At the end of the diet period (Day 28), the intermittent fasting groups (IMF-HFD and IMF-LFD) had greater first meal sizes and faster first meal eating rate compared with their respective ad libitum fed groups on similar diets (HFD and LFD). Also, average meal duration was longer on Day 28 in the low-fat diet groups (LFD and IMF-LFD) compared with high-fat diet groups (HFD and IMF-HFD). After 6weeks of HFD re-feeding (Day 70), there were no differences in meal patterns in groups that had previously experienced intermittent fasting compared with ad libitum fed groups. These findings suggest that meal patterns are only transiently altered during alternate day intermittent fasting for weight loss in obese male mice. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Patterns of Co-occurring Gray Matter Concentration Loss Across the Huntington Disease Prodrome

    Directory of Open Access Journals (Sweden)

    Jennifer Ashley Ciarochi

    2016-09-01

    Full Text Available Huntington disease is caused by an abnormally expanded CAG trinucleotide repeat in the HTT gene. Age and CAG-expansion number are related to age at diagnosis, and can be used to index disease progression. However, observed onset-age variability suggests that other factors also modulate progression. Indexing prodromal (pre-diagnosis progression may highlight therapeutic targets by isolating the earliest-affected factors.We present the largest prodromal Huntington disease application of the univariate method Voxel-based Morphometry, and the first application of the multivariate method Source-based Morphometry, to respectively compare gray matter concentration and capture co-occurring gray matter concentration patterns in control and prodromal participants. Using structural MRI data from 1050 (831 prodromal, 219 control participants, we characterize control-prodromal, whole-brain gray matter concentration differences at various prodromal stages. Our results provide evidence for: (1 Regional co-occurrence and differential patterns of decline across the prodrome, with parietal and occipital differences commonly co-occurring, and frontal and temporal differences being relatively independent from one another, (2 Fronto-striatal circuits being among the earliest and most consistently affected in the prodrome (3 Delayed degradation in some movement-related regions, with increasing subcortical and occipital differences with later progression, (4 An overall superior-to-inferior gradient of gray matter concentration reduction in frontal, parietal, and temporal lobes, (5 The appropriateness of Source-based Morphometry for studying the prodromal Huntington disease population, and its enhanced sensitivity to early prodromal and regionally-concurrent differences.

  7. BNL alternating gradient synchrotron with four helical magnets to minimize the losses of the polarized proton beam

    Directory of Open Access Journals (Sweden)

    N. Tsoupas

    2013-04-01

    Full Text Available The principle of using multiple partial helical magnets to preserve the polarization of the proton beam during its acceleration was applied successfully to the alternating gradient synchrotron (AGS which currently operates with two partial helical magnets. In this paper we further explore this idea by using four partial helical magnets placed symmetrically in the AGS ring. This provides many advantages over the present setup of the AGS, which uses two partial helical magnets. First, the symmetric placement of the four helical magnets and their relatively lower field of operation allows for better control of the AGS optics with reduced values of the beta functions especially near beam injection and allows both the vertical and horizontal tunes to be placed within the “spin tune gap,” therefore eliminating the horizontal and vertical intrinsic spin resonances of the AGS during the acceleration cycle. Second, it provides a wider spin tune gap. Third, the vertical spin direction during beam injection and extraction is closer to vertical. Although the spin tune gap, which is created with four partial helices, can also be created with a single or two partial helices, the high field strength of a single helical magnet which is required to generate such a spin tune gap makes the use of the single helical magnet impractical, and that of the two helical magnets rather difficult. In this paper we will provide results on the spin tune and on the optics of the AGS with four partial helical magnets, and compare them with those from the present setup of the AGS that uses two partial helical magnets. Although in this paper we specifically discuss the effect of the four partial helices on the AGS, this method which can eliminate simultaneously the vertical and horizontal intrinsic spin resonances is a general method and can be applied to any medium energy synchrotron which operates in similar energy range like the AGS and provides the required space to

  8. Patterns of Carbon Storage and Greenhouse Gas Losses in Urban Residential Lawns

    Science.gov (United States)

    Contosta, A.; Varner, R.; Xiao, J.

    2017-12-01

    Population density and housing age are two factors believed to impact carbon (C) storage and greenhouse gas emissions in one of the most extensively managed landscapes in the U.S.: the urban lawn. Previous research focusing on either above- or below-ground C dynamics has also not explicitly considered how they interact to affect the net carbon balance in urban residential areas. We addressed this knowledge gap by quantifying both soil and vegetative C stocks and greenhouse gas fluxes across an urban gradient in Manchester, NH, USA that included 34 lawns comprising three population density categories, five housing age classes, and the interaction between them. Using a combination of both weekly, manual measurements and continuous, automated estimates, we also sampled emissions of CH4, CO2, and N2O within a subset of these lawns that represented a range of citywide population density and housing age characteristics and management practices. We found that neither above- nor below-ground C storage varied with population density, but both differed among housing age classes. Soil C storage increased with housing age and was highest in the oldest lawns sampled. By contrast, C stocks in aboveground, woody biomass was highest at intermediate ages and lowest in older and new parcels. Unlike C stocks, soil greenhouse gas emissions did not change among population density categories, housing age classes, or with irrigation and fertilization management, but instead followed temporal trends in soil moisture and temperature. Overall, our results suggest that drivers of C storage and greenhouse gas losses in urban residential areas may not be uniform and their accurate representation in Earth system models may require a variety of approaches.

  9. Three-dimensional evaluation of pharyngeal airway in individuals with varying growth patterns using cone beam computed tomography

    Directory of Open Access Journals (Sweden)

    Rohan Diwakar

    2015-01-01

    Full Text Available Introduction: The purpose of this study was to evaluate the pharyngeal airway volume in individuals with different vertical growth patterns. Methods: Cone beam computed tomography scans were evaluated of 40 subjects with the age range from 14 to 25 years and were divided into three groups. Horizontal growers consisted of 13 subjects, normal growers consisted of 14 subjects, and the vertical growers consisted of 13 subjects. The pharyngeal airway volume was measured using In Vivo Dental 5.1 software (Anatomage, Anatomy Imaging Software, San Jose, CA, USA. Results: The results obtained were analyzed statistically. The statistical test used for the analysis of the result was Student′s t-test. The independent t-test was done to compare the mean of the pharyngeal airway between the normal growers and horizontal growers and between the normal growers and the vertical growers. No statistically significant difference between the three groups was found in the volumetric measurements of the various sections of airway. Conclusions: Pharyngeal airway volume does not differ significantly in different vertical jaw relationships. It was possible to evaluate the pharyngeal airway volume three dimensionally.

  10. Distinct Patterns of Gene Gain and Loss: Diverse Evolutionary Modes of NBS-Encoding Genes in Three Solanaceae Crop Species.

    Science.gov (United States)

    Qian, Lan-Hua; Zhou, Guang-Can; Sun, Xiao-Qin; Lei, Zhao; Zhang, Yan-Mei; Xue, Jia-Yu; Hang, Yue-Yu

    2017-05-05

    Plant resistance conferred by nucleotide binding site (NBS)-encoding resistance genes plays a key role in the defense against various pathogens throughout the entire plant life cycle. However, comparative analyses for the systematic evaluation and determination of the evolutionary modes of NBS-encoding genes among Solanaceae species are rare. In this study, 447, 255, and 306 NBS-encoding genes were identified from the genomes of potato, tomato, and pepper, respectively. These genes usually clustered as tandem arrays on chromosomes; few existed as singletons. Phylogenetic analysis indicated that three subclasses [TNLs (TIR-NBS-LRR), CNLs (CC-NBS-LRR), and RNLs (RPW8-NBS-LRR)] each formed a monophyletic clade and were distinguished by unique exon/intron structures and amino acid motif sequences. By comparing phylogenetic and systematic relationships, we inferred that the NBS-encoding genes in the present genomes of potato, tomato, and pepper were derived from 150 CNL, 22 TNL, and 4 RNL ancestral genes, and underwent independent gene loss and duplication events after speciation. The NBS-encoding genes therefore exhibit diverse and dynamic evolutionary patterns in the three Solanaceae species, giving rise to the discrepant gene numbers observed today. Potato shows a "consistent expansion" pattern, tomato exhibits a pattern of "first expansion and then contraction," and pepper presents a "shrinking" pattern. The earlier expansion of CNLs in the common ancestor led to the dominance of this subclass in gene numbers. However, RNLs remained at low copy numbers due to their specific functions. Along the evolutionary process of NBS-encoding genes in Solanaceae, species-specific tandem duplications contributed the most to gene expansions. Copyright © 2017 Qian et al.

  11. Beam diagnostics

    CERN Document Server

    Raich, U

    2008-01-01

    Most beam measurements are based on the electro-magnetic interaction of fields induced by the beam with their environment. Beam current transformers as well as beam position monitors are based on this principle. The signals induced in the sensors must be amplified and shaped before they are converted into numerical values. These values are further treated numerically in order to extract meaningful machine parameter measurements. The lecture introduces the architecture of an instrument and shows where in the treatment chain digital signal analysis can be introduced. Then the use of digital signal processing is presented using tune measurements, orbit and trajectory measurements as well as beam loss detection and longitudinal phase space tomography as examples. The hardware as well as the treatment algorithms and their implementation on Digital Signal Processors (DSPs) or in Field Programmable Gate Arrays (FPGAs) are presented.

  12. Merged-beams energy-loss technique for electron-ion excitation: Absolute total cross sections for O5+(2s→2p)

    International Nuclear Information System (INIS)

    Bell, E.W.; Guo, X.Q.; Forand, J.L.; Rinn, K.; Swenson, D.R.; Thompson, J.S.; Dunn, G.H.; Bannister, M.E.; Gregory, D.C.; Phaneuf, R.A.; Smith, A.C.H.; Mueller, A.; Timmer, C.A.; Wahlin, E.K.; DePaola, B.D.; Belic, D.S.

    1994-01-01

    A merged-beams electron-energy-loss technique is described, by which absolute cross sections can be measured for near-threshold electron-impact excitation of multipy charged ions. Results are reported here for absolute total electron-impact excitation cross sections for the O 5+ (2s→2p) transition from below threshold to 1.6 eV above threshold. The experimental data are in good agremeent with a seven-state close-coupling calculation throughout the energy range of the experiment. Results agree with calculations showing that more than 90% of the electrons causing excitation are ejected in the backward direction in the center-of-mass frame. This backscattering is shown in both quantum-mechanical and semiclassical calculations. Evidence is observed for high-lying metastable autoionizing states with a lifetime of approximately 0.9 μs which are made to ionize by electron impact

  13. Exploring proximity effects and large depth of field in helium ion beam lithography: large-area dense patterns and tilted surface exposure.

    Science.gov (United States)

    Flatabø, Ranveig; Agarwal, Akshay; Hobbs, Richard; Greve, Martin Møeller; Holst, Bodil; Berggren, Karl K

    2018-04-13

    Helium ion beam lithography (HIL) is an emerging nanofabrication technique. It benefits from a reduced interaction volume compared to that of an electron beam of similar energy, and hence reduced long-range scattering (proximity effect), higher resist sensitivity and potentially higher resolution. Furthermore, the small angular spread of the helium ion beam gives rise to a large depth of field. This should enable patterning on tilted and curved surfaces without the need of any additional adjustments, such as laser-auto focus. So far, most work on helium ion beam lithography has been focused on exploiting the reduced proximity effect to reach single-digit nanometer resolution, and has thus been concentrated on single-pixel exposures over small areas. Here we explore two new areas of application. Firstly, we investigate the proximity effect in large area exposures and demonstrate HIL's capabilities in fabricating precise high-density gratings on large planar surfaces (100 µm × 100 µm, with pitch down to 35 nm). Secondly, we exploit the large depth of field by making the first HIL patterns on tilted surfaces (sample stage tilted 45◦). We demonstrate a depth of field greater than 100 µm for a resolution of about 20 nm. © 2018 IOP Publishing Ltd.

  14. Beam-beam effects in the Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Shiltsev, V.; Alexahin, Y.; Lebedev, V.; Lebrun, P.; Moore, R.S.; Sen, T.; Tollestrup, A.; Valishev, A.; Zhang, X.L.; /Fermilab

    2005-01-01

    The Tevatron in Collider Run II (2001-present) is operating with 6 times more bunches, many times higher beam intensities and luminosities than in Run I (1992-1995). Electromagnetic long-range and head-on interactions of high intensity proton and antiproton beams have been significant sources of beam loss and lifetime limitations. We present observations of the beam-beam phenomena in the Tevatron and results of relevant beam studies. We analyze the data and various methods employed in operations, predict the performance for planned luminosity upgrades, and discuss ways to improve it.

  15. Characterizing the propagation evolution of wave patterns and vortex structures in astigmatic transformations of Hermite–Gaussian beams

    Science.gov (United States)

    Chen, Y. F.; Chang, C. C.; Lee, C. Y.; Tung, J. C.; Liang, H. C.; Huang, K. F.

    2018-01-01

    Theoretical wave functions are analytically derived to characterize the propagation evolution of the Hermite–Gaussian (HG) beams transformed by a single-lens astigmatic mode converter with arbitrary angle. The derived wave functions are related to the combination of the rotation transform and the antisymmetric fractional Fourier transform. The derived formula is systematically validated by using an off-axis diode-pumped solid-state laser to generate various high-order HG beams for mode conversions. In addition to validation, the creation and evolution of vortex structures in the transformed HG beams are numerically manifested. The present theoretical analyses can be used not only to characterize the evolution of the transformed beams but to design the optical vortex beams with various forms.

  16. Tropical Cyclone Track Convergence Patterns, Arctic Sea-Ice Loss, and Superstorm Sandy: Is There a Connection?

    Science.gov (United States)

    Barnes, C. C.; Francis, J. A.; Byrne, J. M.; Graham, J. R.; McDaniel, S. A.

    2013-12-01

    The potential for disruption to populations and food production due to global climate change will be catastrophic in some regions. Among the most vulnerable regions are those impacted by intensifying or changing tropical cyclones (TC). The objective of this research is to identify historical trends in TC tracks and regional circulation patterns that may forecast increasing risks due to TC intensification under global climate warming. We carry out spatial and temporal analysis of the 1979 - 2011 International Best Track Archive for Climate Stewardship (IBTrACS) historical hurricane database. The data were divided into several subsets to allow analysis of trend in: (i) early (JJAS) and late (OND) seasonal trends; and (ii) multi-year intervals (1979-95 and 1996-2011) to differentiate possible long term trends, if any. Geographical Information Systems (GIS) overlay analysis of the IBTrACS 64 knot hurricane wind radii data identified varying levels of historical tropical cyclone track convergence in the North Atlantic (NA) basin. Results of the track convergence analysis provide a first order analysis regarding changing potential population vulnerabilities due to changing seasonal or long-term tropical cyclone activity. During the summer of 2012, the amount of sea ice on the Arctic Ocean was diminished to about half of its normal extent and 25% of its normal volume relative to the nearly steady conditions that existed before the 1980s. This record loss continues an inexorable decline observed during recent decades. The dramatic increase in open water allows much more solar energy absorption at high latitude. Most of this extra heat returns to the atmosphere in autumn, contributing to the Arctic's rate of warming; exceeding that of mid-latitudes by a factor of two to three, a phenomenon called Arctic Amplification (AA). During October 2012, prior to the arrival of Superstorm Sandy along the eastern seaboard, AA was particularly strong, resulting in a substantial

  17. Presbycusis: a human temporal bone study of individuals with downward sloping audiometric patterns of hearing loss and review of the literature.

    Science.gov (United States)

    Nelson, Erik G; Hinojosa, Raul

    2006-09-01

    The purpose of this retrospective case review was to identify patterns of cochlear element degeneration in individuals with presbycusis exhibiting downward sloping audiometric patterns of hearing loss and to correlate these findings with those reported in the literature to clarify conflicting concepts regarding the association between hearing loss and morphologic abnormalities. Archival human temporal bones from individuals with presbycusis were selected on the basis of strict audiometric criteria for downward-sloping audiometric thresholds. Twenty-one temporal bones that met these criteria were identified and compared with 10 temporal bones from individuals with normal hearing. The stria vascularis volumes, spiral ganglion cell populations, inner hair cells, and outer hair cells were quantitatively evaluated. The relationship between the severity of hearing loss and the degeneration of cochlear elements was analyzed using univariate linear regression models. Outer hair cell loss and ganglion cell loss was observed in all individuals with presbycusis. Inner hair cell loss was observed in 18 of the 21 individuals with presbycusis and stria vascularis loss was observed in 10 of the 21 individuals with presbycusis. The extent of degeneration of all four of the cochlear elements evaluated was highly associated with the severity of hearing loss based on audiometric thresholds at 8,000 Hz and the pure-tone average at 500, 1,000, and 2,000 Hz. The extent of ganglion cell degeneration was associated with the slope of the audiogram. Individuals with downward-sloping audiometric patterns of presbycusis exhibit degeneration of the stria vascularis, spiral ganglion cells, inner hair cells, and outer hair cells that is associated with the severity of hearing loss. This association has not been previously reported in studies that did not use quantitative methodologies for evaluating the cochlear elements and strict audiometric criteria for selecting cases.

  18. Minoxidil dose response study in female pattern hair loss patients determined to be non-responders to 5% topical minoxidil.

    Science.gov (United States)

    McCoy, J; Goren, A; Kovacevic, M; Shapiro, J

    2016-01-01

    Topical minoxidil is the only US FDA approved drug for the treatment of female pattern hair loss (FPHL). 5% minoxidil foam is only effective at re-growing hair in a minority of women (approximately 40%). Thus, the majority of FPHL patients remain untreated. Previously, we demonstrated that nonresponders to 5% minoxidil have low metabolism of minoxidil in hair follicles. As such, we hypothesized that increasing the dosage of topical minoxidil to low metabolizers would increase the number of responders without increasing the incidence of adverse events. In this study, we recruited FPHL subjects that were identified as non-responders to 5% topical minoxidil utilizing the previously validated assay for minoxidil response. Subjects were treated for 12 weeks with a novel 15% topical minoxidil solution. At 12 weeks, 60% of subjects achieved a clinically significant response based on target area hair counts (>13.7% from baseline), as well as significant improvement in global photographic assessment. None of the subjects experienced significant hemodynamic changes or any other adverse events. To the best of our knowledge, this is the first study to demonstrate the potentially beneficial effect of a higher dosage of minoxidil in FPHL subjects who fail to respond to 5% minoxidil.

  19. Monitoring Dosimetric Impact of Weight Loss With Kilovoltage (KV) Cone Beam CT (CBCT) During Parotid-Sparing IMRT and Concurrent Chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Ho, Kean Fatt, E-mail: hokeanfatt@hotmail.com [Academic Radiation Oncology, The Christie NHS Foundation Trust, Manchester (United Kingdom); Marchant, Tom; Moore, Chris; Webster, Gareth; Rowbottom, Carl [North Western Medical Physics, The Christie NHS Foundation Trust, Manchester (United Kingdom); Penington, Hazel [Wade Radiotherapy Research Centre, The Christie NHS Foundation Trust, Manchester (United Kingdom); Lee, Lip; Yap, Beng; Sykes, Andrew; Slevin, Nick [Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester (United Kingdom)

    2012-03-01

    Purpose: Parotid-sparing head-and-neck intensity-modulated radiotherapy (IMRT) can reduce long-term xerostomia. However, patients frequently experience weight loss and tumor shrinkage during treatment. We evaluate the use of kilovoltage (kV) cone beam computed tomography (CBCT) for dose monitoring and examine if the dosimetric impact of such changes on the parotid and critical neural structures warrants replanning during treatment. Methods and materials: Ten patients with locally advanced oropharyngeal cancer were treated with contralateral parotid-sparing IMRT concurrently with platinum-based chemotherapy. Mean doses of 65 Gy and 54 Gy were delivered to clinical target volume (CTV)1 and CTV2, respectively, in 30 daily fractions. CBCT was prospectively acquired weekly. Each CBCT was coregistered with the planned isocenter. The spinal cord, brainstem, parotids, larynx, and oral cavity were outlined on each CBCT. Dose distributions were recalculated on the CBCT after correcting the gray scale to provide accurate Hounsfield calibration, using the original IMRT plan configuration. Results: Planned contralateral parotid mean doses were not significantly different to those delivered during treatment (p > 0.1). Ipsilateral and contralateral parotids showed a mean reduction in volume of 29.7% and 28.4%, respectively. There was no significant difference between planned and delivered maximum dose to the brainstem (p = 0.6) or spinal cord (p = 0.2), mean dose to larynx (p = 0.5) and oral cavity (p = 0.8). End-of-treatment mean weight loss was 7.5 kg (8.8% of baseline weight). Despite a {>=}10% weight loss in 5 patients, there was no significant dosimetric change affecting the contralateral parotid and neural structures. Conclusions: Although patient weight loss and parotid volume shrinkage was observed, overall, there was no significant excess dose to the organs at risk. No replanning was felt necessary for this patient cohort, but a larger patient sample will be investigated

  20. Presbycusis: a human temporal bone study of individuals with flat audiometric patterns of hearing loss using a new method to quantify stria vascularis volume.

    Science.gov (United States)

    Nelson, Erik G; Hinojosa, Raul

    2003-10-01

    The purpose of this study was to determine the prevalence of stria vascularis atrophy in individuals with presbycusis and flat audiometric patterns of hearing loss. Individuals with presbycusis have historically been categorized by the shape of their audiograms, and flat audiometric thresholds have been reported to be associated with atrophy of the stria vascularis. Stria vascularis volume was not measured in these studies. Retrospective case review. Archival human temporal bones from individuals with presbycusis were selected on the basis of strict audiometric criteria for flat audiometric thresholds. Six temporal bones that met these criteria were identified and compared with 10 temporal bones in individuals with normal hearing. A unique quantitative method was developed to measure the stria vascularis volume in these temporal bones. The hair cell and spiral ganglion cell populations also were quantitatively evaluated. Only one of the six individuals with presbycusis and flat audiometric thresholds had significant atrophy of the stria vascularis. This individual with stria vascularis atrophy also had reduced inner hair cell, outer hair cell, and ganglion cell populations. Three of the individuals with presbycusis had spiral ganglion cell loss, three individuals had inner hair cell loss, and all six individuals had outer hair cell loss. The results of this investigation suggest that individuals with presbycusis and flat audiometric patterns of hearing loss infrequently have stria vascularis atrophy. Outer hair cell loss alone or in combination with inner hair cell or ganglion cell loss may be the cause of flat audiometric thresholds in individuals with presbycusis.

  1. High-resolution, high-throughput, positive-tone patterning of poly(ethylene glycol by helium beam exposure through stencil masks.

    Directory of Open Access Journals (Sweden)

    Eliedonna E Cacao

    Full Text Available In this work, a collimated helium beam was used to activate a thiol-poly(ethylene glycol (SH-PEG monolayer on gold to selectively capture proteins in the exposed regions. Protein patterns were formed at high throughput by exposing a stencil mask placed in proximity to the PEG-coated surface to a broad beam of helium particles, followed by incubation in a protein solution. Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR spectra showed that SH-PEG molecules remain attached to gold after exposure to beam doses of 1.5-60 µC/cm(2 and incubation in PBS buffer for one hour, as evidenced by the presence of characteristic ether and methoxy peaks at 1120 cm(-1 and 2870 cm(-1, respectively. X-ray Photoelectron Spectroscopy (XPS spectra showed that increasing beam doses destroy ether (C-O bonds in PEG molecules as evidenced by the decrease in carbon C1s peak at 286.6 eV and increased alkyl (C-C signal at 284.6 eV. XPS spectra also demonstrated protein capture on beam-exposed PEG regions through the appearance of a nitrogen N1s peak at 400 eV and carbon C1s peak at 288 eV binding energies, while the unexposed PEG areas remained protein-free. The characteristic activities of avidin and horseradish peroxidase were preserved after attachment on beam-exposed regions. Protein patterns created using a 35 µm mesh mask were visualized by localized formation of insoluble diformazan precipitates by alkaline phosphatase conversion of its substrate bromochloroindoyl phosphate-nitroblue tetrazolium (BCIP-NBT and by avidin binding of biotinylated antibodies conjugated on 100 nm gold nanoparticles (AuNP. Patterns created using a mask with smaller 300 nm openings were detected by specific binding of 40 nm AuNP probes and by localized HRP-mediated deposition of silver nanoparticles. Corresponding BSA-passivated negative controls showed very few bound AuNP probes and little to no enzymatic formation of diformazan precipitates or silver

  2. RELAP5/MOD2. 5 analysis of the HFBR (High Flux Beam Reactor) for a loss of power and coolant accident

    Energy Technology Data Exchange (ETDEWEB)

    Slovik, G.C.; Rohatgi, U.S.; Jo, Jae.

    1990-05-01

    A set of postulated accidents were evaluated for the High Flux Beam Reactor (HFBR) at Brookhaven National Laboratory. A loss of power accident (LOPA) and a loss of coolant accident (LOCA) were analyzed. This work was performed in response to a DOE review that wanted to update the understanding of the thermal hydraulic behavior of the HFBR during these transients. These calculations were used to determine the margins to fuel damage at the 60 MW power level. The LOPA assumes all the backup power systems fail (although this event is highly unlikely). The reactor scrams, the depressurization valve opens, and the pumps coast down. The HFBR has down flow through the core during normal operation. To avoid fuel damage, the core normally goes through an extended period of forced down flow after a scram before natural circulation is allowed. During a LOPA, the core will go into flow reversal once the buoyancy forces are larger than the friction forces produced during the pump coast down. The flow will stagnate, reverse direction, and establish a buoyancy driven (natural circulation) flow around the core. Fuel damage would probably occur if the critical heat flux (CHF) limit is reached during the flow reversal event. The RELAP5/MOD2.5 code, with an option for heavy water, was used to model the HFBR and perform the LOPA calculation. The code was used to predict the time when the buoyancy forces overcome the friction forces and produce upward directed flow in the core. The Monde CHF correlation and experimental data taken for the HFBR during the design verification phase in 1963 were used to determine the fuel damage margin. 20 refs., 40 figs., 11 tabs.

  3. RELAP5/MOD2.5 analysis of the HFBR [High Flux Beam Reactor] for a loss of power and coolant accident

    International Nuclear Information System (INIS)

    Slovik, G.C.; Rohatgi, U.S.; Jo, Jae.

    1990-05-01

    A set of postulated accidents were evaluated for the High Flux Beam Reactor (HFBR) at Brookhaven National Laboratory. A loss of power accident (LOPA) and a loss of coolant accident (LOCA) were analyzed. This work was performed in response to a DOE review that wanted to update the understanding of the thermal hydraulic behavior of the HFBR during these transients. These calculations were used to determine the margins to fuel damage at the 60 MW power level. The LOPA assumes all the backup power systems fail (although this event is highly unlikely). The reactor scrams, the depressurization valve opens, and the pumps coast down. The HFBR has down flow through the core during normal operation. To avoid fuel damage, the core normally goes through an extended period of forced down flow after a scram before natural circulation is allowed. During a LOPA, the core will go into flow reversal once the buoyancy forces are larger than the friction forces produced during the pump coast down. The flow will stagnate, reverse direction, and establish a buoyancy driven (natural circulation) flow around the core. Fuel damage would probably occur if the critical heat flux (CHF) limit is reached during the flow reversal event. The RELAP5/MOD2.5 code, with an option for heavy water, was used to model the HFBR and perform the LOPA calculation. The code was used to predict the time when the buoyancy forces overcome the friction forces and produce upward directed flow in the core. The Monde CHF correlation and experimental data taken for the HFBR during the design verification phase in 1963 were used to determine the fuel damage margin. 20 refs., 40 figs., 11 tabs

  4. Evaluation of diagnostic accuracy of conventional and digital periapical radiography, panoramic radiography, and cone-beam computed tomography in the assessment of alveolar bone loss.

    Science.gov (United States)

    Takeshita, Wilton Mitsunari; Vessoni Iwaki, Lilian Cristina; Da Silva, Mariliani Chicarelli; Tonin, Renata Hernandes

    2014-07-01

    To evaluate the diagnostic accuracy of different radiographic methods in the assessment of proximal alveolar bone loss (ABL). ABL, the distance between cement-enamel junction and alveolar bone crest, was measured in 70 mandibular human teeth - directly on the mandibles (control), using conventional periapical radiography with film holders (Rinn XCP and Han-Shin), digital periapical radiography with complementary metal-oxide semiconductor sensor, conventional panoramic, and cone-beam computed tomography (CBCT). Three programs were used to measure ABL on the images: Image tool 3.0 (University of Texas Health Sciences Center, San Antonio, Texas, USA), Kodak Imaging 6.1 (Kodak Dental Imaging 6.1, Carestream Health(®), Rochester, NY, USA), and i-CAT vision 1.6.20. Statistical analysis used ANOVA and Tukey's test at 5% significance level. The tomographic images showed the highest means, whereas the lowest were found for periapical with Han-Shin. Controls differed from periapical with Han-Shin (P periapical with Rinn XCP (P = 0.0066), periapical with Han-Shin (P periapical (P = 0.0027). Conventional periapicals with film holders differed from each other (P = 0.0007). Digital periapical differed from conventional periapical with Han-Shin (P = 0.0004). Conventional periapical with Han-Shin film holder was the only method that differed from the controls. CBCT had the closest means to the controls.

  5. Longitudinal assessment of daily activity patterns on weight change after involuntary job loss: the ADAPT study protocol

    Directory of Open Access Journals (Sweden)

    Patricia L. Haynes

    2017-10-01

    Full Text Available Abstract Background The World Health Organization has identified obesity as one of the most visible and neglected public health problems worldwide. Meta-analytic studies suggest that insufficient sleep increases the risk of developing obesity and related serious medical conditions. Unfortunately, the nationwide average sleep duration has steadily declined over the last two decades with 25% of U.S. adults reporting insufficient sleep. Stress is also an important indirect factor in obesity, and chronic stress and laboratory-induced stress negatively impact sleep. Despite what we know from basic sciences about (a stress and sleep and (b sleep and obesity, we know very little about how these factors actually manifest in a natural environment. The Assessing Daily Activity Patterns Through Occupational Transitions (ADAPT study tests whether sleep disruption plays a key role in the development of obesity for individuals exposed to involuntary job loss, a life event that is often stressful and disrupting to an individual’s daily routine. Methods This is an 18-month closed, cohort research design examining social rhythms, sleep, dietary intake, energy expenditure, waist circumference, and weight gain over 18 months in individuals who have sustained involuntary job loss. Approximately 332 participants who lost their job within the last 3 months are recruited from flyers within the Arizona Department of Economic Security (AZDES Unemployment Insurance Administration application packets and other related postings. Multivariate growth curve modeling will be used to investigate the temporal precedence of changes in social rhythms, sleep, and weight gain. Discussion It is hypothesized that: (1 unemployed individuals with less consistent social rhythms and worse sleep will have steeper weight gain trajectories over 18 months than unemployed individuals with stable social rhythms and better sleep; (2 disrupted sleep will mediate the relationship between

  6. A cross-sectional analysis of age and sex patterns in grip strength, tooth loss, near vision and hearing levels in Chinese aged 50-74 years

    DEFF Research Database (Denmark)

    Wu, Yili; Pang, Zengchang; Zhang, Dongfeng

    2012-01-01

    By focusing on four health variables, handgrip strength, near visual acuity, tooth loss and hearing level, this study examined the different patterns of age-related changes in these variables in Chinese aged from 50 to 74 years, as well as explored the relationship among the variables in a cross-...

  7. Beam-loss induced pressure rise of Large Hadron Collider collimator materials irradiated with 158  GeV/u In^{49+} ions at the CERN Super Proton Synchrotron

    Directory of Open Access Journals (Sweden)

    E. Mahner

    2004-10-01

    Full Text Available During heavy ion operation, large pressure rises, up to a few orders of magnitude, were observed at CERN, GSI, and BNL. The dynamic pressure rises were triggered by lost beam ions that impacted onto the vacuum chamber walls and desorbed about 10^{4} to 10^{7} molecules per ion. The deterioration of the dynamic vacuum conditions can enhance charge-exchange beam losses and can lead to beam instabilities or even to beam abortion triggered by vacuum interlocks. Consequently, a dedicated measurement of heavy-ion induced molecular desorption in the GeV/u energy range is important for Large Hadron Collider (LHC ion operation. In 2003, a desorption experiment was installed at the Super Proton Synchrotron to measure the beam-loss induced pressure rise of potential LHC collimator materials. Samples of bare graphite, sputter coated (Cu, TiZrV graphite, and 316 LN (low carbon with nitrogen stainless steel were irradiated under grazing angle with 158  GeV/u indium ions. After a description of the new experimental setup, the results of the pressure rise measurements are presented, and the derived desorption yields are compared with data from other experiments.

  8. Changing Patterns of Emerging Zoonotic Diseases in Wildlife, Domestic Animals, and Humans Linked to Biodiversity Loss and Globalization.

    Science.gov (United States)

    Aguirre, A Alonso

    2017-12-15

    The fundamental human threats to biodiversity including habitat destruction, globalization, and species loss have led to ecosystem disruptions altering infectious disease transmission patterns, the accumulation of toxic pollutants, and the invasion of alien species and pathogens. To top it all, the profound role of climate change on many ecological processes has affected the inability of many species to adapt to these relatively rapid changes. This special issue, "Zoonotic Disease Ecology: Effects on Humans, Domestic Animals and Wildlife," explores the complex interactions of emerging infectious diseases across taxa linked to many of these anthropogenic and environmental drivers. Selected emerging zoonoses including RNA viruses, Rift Valley fever, trypanosomiasis, Hanta virus infection, and other vector-borne diseases are discussed in detail. Also, coprophagous beetles are proposed as important vectors in the transmission and maintenance of infectious pathogens. An overview of the impacts of climate change in emerging disease ecology within the context of Brazil as a case study is provided. Animal Care and Use Committee requirements were investigated, concluding that ecology journals have low rates of explicit statements regarding the welfare and wellbing of wildlife during experimental studies. Most of the solutions to protect biodiversity and predicting and preventing the next epidemic in humans originating from wildlife are oriented towards the developed world and are less useful for biodiverse, low-income economies. We need the development of regional policies to address these issues at the local level. © The Author(s) 2017. Published by Oxford University Press on behalf of the National Academy of Sciences. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  9. Parietal scalp is another affected area in female pattern hair loss: an analysis of hair density and hair diameter

    Directory of Open Access Journals (Sweden)

    Rojhirunsakool S

    2017-12-01

    Full Text Available Salinee Rojhirunsakool, Poonkiat Suchonwanit Department of Medicine, Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Purpose: Female pattern hair loss (FPHL is a common hair disease. However, studies of the quantitative measurement of FPHL are still limited. The aim of this study was to investigate the characteristics of hair density and hair diameter in normal women and FPHL patients, and further correlate the quantitative measurement with the clinical presentation of FPHL.Patients and methods: An evaluation of 471 FPHL patients and 236 normal women was carried out according to the Ludwig classification, and analysis was performed by using a computerized handheld USB camera with computer-assisted software. Various areas of the scalp, including frontal, parietal, midscalp, and occipital, were analyzed for hair density, non-vellus hair diameter, and percentage of miniaturized hair.Results: The hair density in normal women was the highest and the lowest in the midscalp and parietal areas, respectively. The FPHL group revealed the lowest hair density in the parietal area. Significant differences in hair density, non-vellus hair diameter, and percentage of miniaturized hair between the normal and FPHL groups were observed, especially in the midscalp and parietal areas.Conclusion: The parietal area is another important affected area in FPHL in addition to the midscalp area. This finding provides novel important information of FPHL and will be useful for hair transplant surgeons choosing the optimal donor sites for hair transplantation in women. Keywords: androgenetic alopecia, alopecia, phototrichogram, miniaturization

  10. IMPACT simulation and the SNS linac beam

    International Nuclear Information System (INIS)

    Zhang, Y.; Qiang, J.

    2008-01-01

    Multi-particle tracking simulations for the SNS linac beam dynamics studies are performed with the IMPACT code. Beam measurement results are compared with the computer simulations, including beam longitudinal halo and beam losses in the superconducting linac, transverse beam Courant-Snyder parameters and the longitudinal beam emittance in the linac. In most cases, the simulations show good agreement with the measured results

  11. Beam halo in high-intensity beams

    International Nuclear Information System (INIS)

    Wangler, T.P.

    1993-01-01

    In space-charge dominated beams the nonlinear space-charge forces produce a filamentation pattern, which in projection to the 2-D phase spaces results in a 2-component beam consisting of an inner core and a diffuse outer halo. The beam-halo is of concern for a next generation of cw, high-power proton linacs that could be applied to intense neutron generators for nuclear materials processing. The author describes what has been learned about beam halo and the evolution of space-charge dominated beams using numerical simulations of initial laminar beams in uniform linear focusing channels. Initial results are presented from a study of beam entropy for an intense space-charge dominated beam

  12. Diffuse nitrogen loss simulation and impact assessment of stereoscopic agriculture pattern by integrated water system model and consideration of multiple existence forms

    Science.gov (United States)

    Zhang, Yongyong; Gao, Yang; Yu, Qiang

    2017-09-01

    Agricultural nitrogen loss becomes an increasingly important source of water quality deterioration and eutrophication, even threatens water safety for humanity. Nitrogen dynamic mechanism is still too complicated to be well captured at watershed scale due to its multiple existence forms and instability, disturbance of agricultural management practices. Stereoscopic agriculture is a novel agricultural planting pattern to efficiently use local natural resources (e.g., water, land, sunshine, heat and fertilizer). It is widely promoted as a high yield system and can obtain considerable economic benefits, particularly in China. However, its environmental quality implication is not clear. In our study, Qianyanzhou station is famous for its stereoscopic agriculture pattern of Southern China, and an experimental watershed was selected as our study area. Regional characteristics of runoff and nitrogen losses were simulated by an integrated water system model (HEQM) with multi-objective calibration, and multiple agriculture practices were assessed to find the effective approach for the reduction of diffuse nitrogen losses. Results showed that daily variations of runoff and nitrogen forms were well reproduced throughout watershed, i.e., satisfactory performances for ammonium and nitrate nitrogen (NH4-N and NO3-N) loads, good performances for runoff and organic nitrogen (ON) load, and very good performance for total nitrogen (TN) load. The average loss coefficient was 62.74 kg/ha for NH4-N, 0.98 kg/ha for NO3-N, 0.0004 kg/ha for ON and 63.80 kg/ha for TN. The dominating form of nitrogen losses was NH4-N due to the applied fertilizers, and the most dramatic zones aggregated in the middle and downstream regions covered by paddy and orange orchard. In order to control diffuse nitrogen losses, the most effective practices for Qianyanzhou stereoscopic agriculture pattern were to reduce farmland planting scale in the valley by afforestation, particularly for orchard in the

  13. Evaluation of diagnostic accuracy of conventional and digital periapical radiography, panoramic radiography, and cone-beam computed tomography in the assessment of alveolar bone loss

    Directory of Open Access Journals (Sweden)

    Wilton Mitsunari Takeshita

    2014-01-01

    Full Text Available Background: To evaluate the diagnostic accuracy of different radiographic methods in the assessment of proximal alveolar bone loss (ABL. Materials and Methods: ABL, the distance between cement-enamel junction and alveolar bone crest, was measured in 70 mandibular human teeth - directly on the mandibles (control, using conventional periapical radiography with film holders (Rinn XCP and Han-Shin, digital periapical radiography with complementary metal-oxide semiconductor sensor, conventional panoramic, and cone-beam computed tomography (CBCT. Three programs were used to measure ABL on the images: Image tool 3.0 (University of Texas Health Sciences Center, San Antonio, Texas, USA, Kodak Imaging 6.1 (Kodak Dental Imaging 6.1, Carestream Health ® , Rochester, NY, USA, and i-CAT vision 1.6.20. Statistical analysis used ANOVA and Tukey′s test at 5% significance level. Results: The tomographic images showed the highest means, whereas the lowest were found for periapical with Han-Shin. Controls differed from periapical with Han-Shin (P < 0.0001. CBCT differed from panoramic (P = 0.0130, periapical with Rinn XCP (P = 0.0066, periapical with Han-Shin (P < 0.0001, and digital periapical (P = 0.0027. Conventional periapicals with film holders differed from each other (P = 0.0007. Digital periapical differed from conventional periapical with Han-Shin (P = 0.0004. Conclusions: Conventional periapical with Han-Shin film holder was the only method that differed from the controls. CBCT had the closest means to the controls.

  14. Studies of the beam extraction system of the GTS-LHC electron cyclotron resonance ion source at CERN.

    Science.gov (United States)

    Toivanen, V; Küchler, D

    2016-02-01

    The 14.5 GHz GTS-LHC Electron Cyclotron Resonance Ion Source (ECRIS) provides multiply charged heavy ion beams for the CERN experimental program. The GTS-LHC beam formation has been studied extensively with lead, argon, and xenon beams with varied beam extraction conditions using the ion optical code IBSimu. The simulation model predicts self-consistently the formation of triangular and hollow beam structures which are often associated with ECRIS ion beams, as well as beam loss patterns which match the observed beam induced markings in the extraction region. These studies provide a better understanding of the properties of the extracted beams and a way to diagnose the extraction system performance and limitations, which is otherwise challenging due to the lack of direct diagnostics in this region and the limited availability of the ion source for development work.

  15. Does stress influence sleep patterns, food intake, weight gain, abdominal obesity and weight loss interventions and vice versa?

    DEFF Research Database (Denmark)

    Geiker, Nina Rica Wium; Astrup, Arne; Hjorth, Mads Fiil

    2018-01-01

    subjects. This review summarizes the scientific evidence on the role mental stress (either in or not in association with impaired sleep) may play in poor sleep, enhanced appetite, cravings and decreased motivation for physical activity. All these factors contribute to weight gain and obesity, possibly via...... decreasing the efficacy of weight loss interventions. We also review evidence for the role that lifestyle and stress management may play in achieving weight loss in stress-vulnerable individuals with overweight....

  16. Impaired spatial pattern separation performance in temporal lobe epilepsy is associated with visuospatial memory deficits and hippocampal volume loss.

    Science.gov (United States)

    Reyes, Anny; Holden, Heather M; Chang, Yu-Hsuan A; Uttarwar, Vedang S; Sheppard, David P; DeFord, Nicole E; DeJesus, Shannon Yandall; Kansal, Leena; Gilbert, Paul E; McDonald, Carrie R

    2018-03-01

    Individuals with chronic temporal lobe epilepsy (TLE) experience episodic memory deficits that may be progressive in nature. These memory decrements have been shown to increase with the extent of hippocampal damage, a hallmark feature of TLE. Pattern separation, a neural computational mechanism thought to play a role in episodic memory formation, has been shown to be negatively affected by aging and in individuals with known hippocampal dysfunction. Despite the link between poor pattern separation performance and episodic memory deficits, behavioral pattern separation has not been examined in patients with TLE. We examined pattern separation performance in a group of 22 patients with medically-refractory TLE and 20 healthy adults, using a task hypothesized to measure spatial pattern separation with graded levels of spatial interference. We found that individuals with TLE showed less efficient spatial pattern separation performance relative to healthy adults. Poorer spatial pattern separation performance in TLE was associated with poorer visuospatial memory, but only under high interference conditions. In addition, left hippocampal atrophy was associated with poor performance in the high interference condition in TLE. These data suggest that episodic memory impairments in patients with chronic, refractory TLE may be partially due to less efficient pattern separation, which likely reflects their underlying hippocampal dysfunction. Copyright © 2018 Elsevier Ltd. All rights reserved.

  17. The SPS Beam quality monitor, from design to operation

    CERN Document Server

    Papotti, G; Follin, F; Shaposhnikova, E

    2011-01-01

    The SPS Beam Quality Monitor is a system that monitors longitudinal beam parameters on a cycle-by-cycle basis and prevents extraction to the LHC in case the specifications are not met. This avoids losses, unnecessary stress of machine protection components and luminosity degradation, additionally helping efficiency during the filling process. The system has been operational since the 2009 LHC run, checking the beam pattern, its correct position with respect to the LHC references, individual bunch lengths and stability. In this paper the algorithms used, the hardware implementation and the operational aspects are presented.

  18. Measurement of Beam Lifetime and Applications for SPEAR3

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Xiaobiao; Corbett, Jeff; /SLAC

    2011-04-05

    Beam lifetime studies for the SPEAR3 storage ring are presented. The three lifetime components are separated with lifetime measurements under various combinations of beam currents and fill patterns and vertical scraper scans. Touschek lifetime is studied with rf voltage scans and with the horizontal or vertical scrapers inserted. The measurements are explained with calculations based on the calibrated lattice model. Quantum lifetime measurements are performed with reduced longitudinal and horizontal apertures, respectively, from which we deduce the radiation energy loss down to a few keV per revolution and the horizontal beam size.

  19. Comparison of interradicular distances and cortical bone thickness in Thai patients with class I and class II skeletal patterns using cone-beam computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Khumsarn, Nattida [Dental Division of Lamphun Hospital, Lamphun (Thailand); Patanaporn, Virush; Janhom, Apirum; Jotikasthira, Dhirawat [Faculty of Dentistry, Chiang Mai University, Chiang Mai (Thailand)

    2016-06-15

    This study evaluated and compared interradicular distances and cortical bone thickness in Thai patients with Class I and Class II skeletal patterns, using cone-beam computed tomography (CBCT). Pretreatment CBCT images of 24 Thai orthodontic patients with Class I and Class II skeletal patterns were included in the study. Three measurements were chosen for investigation: the mesiodistal distance between the roots, the width of the buccolingual alveolar process, and buccal cortical bone thickness. All distances were recorded at five different levels from the cementoenamel junction (CEJ). Descriptive statistical analysis and t-tests were performed, with the significance level for all tests set at p<0.05. Patients with a Class II skeletal pattern showed significantly greater maxillary mesiodistal distances (between the first and second premolars) and widths of the buccolingual alveolar process (between the first and second molars) than Class I skeletal pattern patients at 10 mm above the CEJ. The maxillary buccal cortical bone thicknesses between the second premolar and first molar at 8 mm above the CEJ in Class II patients were likewise significantly greater than in Class I patients. Patients with a Class I skeletal pattern showed significantly wider mandibular buccolingual alveolar processes than did Class II patients (between the first and second molars) at 4, 6, and 8 mm below the CEJ. In both the maxilla and mandible, the mesiodistal distances, the width of the buccolingual alveolar process, and buccal cortical bone thickness tended to increase from the CEJ to the apex in both Class I and Class II skeletal patterns.

  20. Ion Accelerator Merges Several Beams

    Science.gov (United States)

    Aston, G.

    1984-01-01

    Intense ion beam formed by merging multiple ion beamlets into one concentrated beam. Beamlet holes in graphite screen and focusing grids arranged in hexagonal pattern. Merged beam passes through single hole in each of aluminum accelerator and decelerator grids. Ion extraction efficiency, beam intensity, and focusing improved.

  1. Patterns and Drivers of Scattered Tree Loss in Agricultural Landscapes: Orchard Meadows in Germany (1968-2009)

    Science.gov (United States)

    Plieninger, Tobias; Levers, Christian; Mantel, Martin; Costa, Augusta; Schaich, Harald; Kuemmerle, Tobias

    2015-01-01

    Scattered trees support high levels of farmland biodiversity and ecosystem services in agricultural landscapes, but they are threatened by agricultural intensification, urbanization, and land abandonment. This study aimed to map and quantify the decline of orchard meadows (scattered fruit trees of high nature conservation value) for a region in Southwestern Germany for the 1968 2009 period and to identify the driving forces of this decline. We derived orchard meadow loss from 1968 and 2009 aerial images and used a boosted regression trees modelling framework to assess the relative importance of 18 environmental, demographic, and socio-economic variables to test five alternative hypothesis explaining orchard meadow loss. We found that orchard meadow loss occurred in flatter areas, in areas where smaller plot sizes and fragmented orchard meadows prevailed, and in areas near settlements and infrastructure. The analysis did not confirm that orchard meadow loss was higher in areas where agricultural intensification was stronger and in areas of lower implementation levels of conservation policies. Our results demonstrated that the influential drivers of orchard meadow loss were those that reduce economic profitability and increase opportunity costs for orchards, providing incentives for converting orchard meadows to other, more profitable land uses. These insights could be taken up by local- and regional-level conservation policies to identify the sites of persistent orchard meadows in agricultural landscapes that would be prioritized in conservation efforts. PMID:25932914

  2. Height loss with advancing age in a hospitalized population of Polish men and women: magnitude, pattern and associations with mortality

    Directory of Open Access Journals (Sweden)

    Chmielewski Piotr

    2015-06-01

    Full Text Available The connection between the rate of height loss in older people and their general health status has been well documented in the medical literature. Our study was aimed at furthering the characterization of this interrelationship in the context of health indices and mortality in a hospitalized population of Polish adults. Data were collated from a literature review and from a longitudinal study of aging carried out in the Polish population which followed 142 physically healthy inmates, including 68 men and 74 women, for at least 25 years from the age of 45 onwards. Moreover, cross-sectional data were available from 225 inmates, including 113 men and 112 women. These subjects were confined at the same hospital. ANOVA, t-test, and regression analysis were employed. The results indicate that the onset of height loss emerges in the fourth and five decade of life and there is a gradual acceleration of reduction of height at later stages of ontogeny in both sexes. Postmenopausal women experience a more rapid loss of height compared with men. The individuals who had higher rate of loss of height (≥3 cm/decade tend to be at greater risk of cardiovascular events and all-cause mortality. In conclusion, our findings suggest that a systematic assessment of the rate of loss of height can be useful for clinicians caring for elderly people because of its prognostic value in terms of morbidity and mortality.

  3. Habitual physical activity and plasma metabolomic patterns distinguish individuals with low vs. high weight loss during controlled energy restriction.

    Science.gov (United States)

    Piccolo, Brian D; Keim, Nancy L; Fiehn, Oliver; Adams, Sean H; Van Loan, Marta D; Newman, John W

    2015-04-01

    Total weight loss induced by energy restriction is highly variable even under tightly controlled conditions. Identifying weight-loss discriminants would provide a valuable weight management tool and insights into body weight regulation. This study characterized responsiveness to energy restriction in adults from variables including the plasma metabolome, endocrine and inflammatory markers, clinical indices, body composition, diet, and physical activity. Data were derived from a controlled feeding trial investigating the effect of 3-4 dairy product servings in an energy-restricted diet (2092 kJ/d reduction) over 12 wk. Partial least squares regression was used to identify weight-loss discriminants in 67 overweight and obese adults. Linear mixed models were developed to identify discriminant variable differences in high- vs. low-weight-loss responders. Both pre- and postintervention variables (n = 127) were identified as weight-loss discriminants (root mean squared error of prediction = 1.85 kg; Q(2) = 0.43). Compared with low-responders (LR), high-responders (HR) had greater decreases in body weight (LR: 2.7 ± 1.6 kg; HR: 9.4 ± 1.8 kg, P physical activity (LR: 127 ± 52 min; HR: 167 ± 68 min, P = 0.02), sedentary activity (LR: 1090 ± 99 min; HR: 1017 ± 110 min, P = 0.02), and plasma stearate [LR: 102,000 ± 21,000 quantifier ion peak height (QIPH); HR: 116,000 ± 24,000 QIPH, P = 0.01]. Overweight and obese individuals highly responsive to energy restriction had accelerated reductions in adiposity, likely supported in part by higher lipid mobilization and combustion. A novel observation was that person-to-person differences in habitual physical activity and magnitude of weight loss were accompanied by unique blood metabolite signatures. This trial was registered at clinicaltrials.gov as NCT00858312. © 2015 American Society for Nutrition.

  4. Impact of childhood trauma and cognitive emotion regulation strategies on risk-aversive and loss-aversive patterns of decision-making in patients with depression.

    Science.gov (United States)

    Huh, Hyu Jung; Baek, Kwangyeol; Kwon, Jae-Hyung; Jeong, Jaeseung; Chae, Jeong-Ho

    2016-11-01

    Although poor decision-making ultimately impairs quality of life in depression, few studies describe the clinical characteristics of patients suffering from dysfunctional decision-making. This study aims to delineate the effect of childhood trauma and other personality factors on risk-aversive and loss-aversive patterns of decision-making in patients with depression. A total of 50 depressive patients completed surveys for the measurement of sociodemographic factors, trauma loads and other clinical characteristics, including depression, anxiety, and strategies for emotion regulation. Risk aversion and loss aversion were quantified using probability discounting task and a 50:50 gamble on monetary decision-making task under specified risks. Stepwise multiple regression analysis was performed to determine the factors, predicting risk aversion or loss aversion in depression. Childhood trauma was the most prominent factor predicting loss aversion in patients with depressive disorders. Overall maladaptive emotion regulation strategies were associated with risk aversion. Childhood trauma and specific strategies of emotion regulation contribute to risk or loss aversion in patients with depression. These findings may provide useful insight into elaborative evaluation and interventions to improve decision-making and quality of life in patients with depression.

  5. Fabrication of Molds with 25-nm Dot-Pitch Pattern by Focused Ion Beam and Reactive Ion Etching for Nanoimprint Using Metallic Glass

    Science.gov (United States)

    Fukuda, Yasuyuki; Saotome, Yasunori; Nishiyama, Nobuyuki; Saidoh, Noriko; Makabe, Eiichi; Inoue, Akihisa

    2012-08-01

    Here we attempted to fabricate molds (dies) of nanodot arrays with a 25-nm pitch and to nanoimprint metallic glass for developing bit-patterned media with an ultrahigh recording density of 1 Tbit/in.2. The mold-fabricating process consisted of mask patterning by focused ion beam assisted chemical vapor deposition (FIB-CVD) and reactive ion etching (RIE). We investigated the feasibility of a Pt-deposited metal etching mask on SiO2 on Si and diamond like carbon (DLC) on Al2O3 substrates, and achieved isolated convex nanodot arrays with a 25-nm pitch and an aspect ratio of 1.8 by RIE with O2 plasma on a DLC/Al2O3 substrate. Subsequently, we nanoimprinted Pt-based metallic glass by using the fabricated molds and successfully replicated fine concave nanohole arrays. The results suggest that the FIB-CVD/RIE process is a promising technique for fabricating ultrafine nanopatterned molds, and metallic glasses are ideal nanoimprintable materials for mass producing nanodevices such as bit-patterned media.

  6. Story Retelling Pattern among Children with and without Hearing Loss: Effects of Repeated Practice and Parent-Child Attunement

    Science.gov (United States)

    Robertson, Lyn; Dow, Gina Annunziato; Hainzinger, Sarah Lynn

    2006-01-01

    In two analyses, transcripts from 21 children (ages 3-6) reading and retelling stories with a parent over a six-week period were studied. Ten children with moderate-to-profound hearing loss used assistive technology and the Auditory-Verbal approach for language learning; 11 had typical hearing. In Analysis 1, no significant difference between…

  7. Thermally induced diffraction losses for a Gaussian pump beam and optimization of the mode-to-pump ratio in an end-pumped Nd:GdVO4 laser

    International Nuclear Information System (INIS)

    Wang, Y T; Li, W J; Pan, L L; Yu, J T; Zhang, R H

    2013-01-01

    The analytical model of thermally induced diffraction losses for a Gaussian pump beam are derived as functions of the mode-to-pump ratio and pump power in end-pumped Nd-doped lasers considering the energy transfer upconversion effects. The mode-to-pump ratio is optimized based on it. The results show that the optimum mode-to-pump ratio with the thermally induced diffraction losses is less than 0.65, and it is less than the results in which the thermally induced diffraction losses are neglected. The theoretical model is applied to a diode-end-pumped Nd:GdVO 4 laser operating at 1342 nm, and the theoretical calculations are in good agreement with the experimental results. (paper)

  8. Ion irradiation effects on a magnetic Si/Ni/Si trilayer and lateral magnetic-nonmagnetic multistrip patterning by focused ion beam

    Science.gov (United States)

    Dev, B. N.; Banu, Nasrin; Fassbender, J.; Grenzer, J.; Schell, N.; Bischoff, L.; Groetzschel, R.; McCord, J.

    2017-10-01

    Fabrication of a multistrip magnetic/nonmagnetic structure in a thin sandwiched Ni layer [Si(5 nm)/Ni(15 nm)/Si] by a focused ion beam (FIB) irradiation has been attempted. A control experiment was initially performed by irradiation with a standard 30 keV Ga ion beam at various fluences. Analyses were carried out by Rutherford backscattering spectrometry, X-ray reflectivity, magnetooptical Kerr effect (MOKE) measurements and MOKE microscopy. With increasing ion fluence, the coercivity as well as Kerr rotation decreases. A threshold ion fluence has been identified, where ferromagnetism of the Ni layer is lost at room temperature and due to Si incorporation into the Ni layer, a Ni0.68Si0.32 alloy layer is formed. This fluence was used in FIB irradiation of parallel 50 nm wide stripes, leaving 1 µm wide unirradiated stripes in between. MOKE microscopy on this FIB-patterned sample has revealed interacting magnetic domains across several stripes. Considering shape anisotropy effects, which would favour an alignment of magnetization parallel to the stripe axis, the opposite behaviour is observed. Magneto-elastic effects introducing a stress-induced anisotropy component oriented perpendicular to the stripe axis are the most plausible explanation for the observed behaviour.

  9. Surface Modification of Silicone Rubber for Adhesion Patterning of Mesenchymal Stem Cells by Water Cluster Ion Beam

    Science.gov (United States)

    Sommani, Piyanuch; Ichihashi, Gaku; Ryuto, Hiromichi; Tsuji, Hiroshi; Gotoh, Yasuhito; Takaoka, Gikan H.

    2011-01-01

    Biocompatibility of silicone rubber sheet (SR) was improved by the water cluster ion irradiation for adhesion patterning of mesenchymal stem cells (MSCs). The water cluster ions were irradiated at acceleration voltage of 6 kV and doses of 1014-1016 ions/cm2. The effect of ion dose on changes in wettability and surface atomic bonding state was observed. Compared to the unirradiated SR, about four-time smoother surface on the irradiated one was observed. Water contact angle decreased with an increase in the ion dose up to 1×1015 ions/cm2. With an increase in ion dose, XPS showed decrease of atomic carbon due to lateral sputtering effect and increase of atomic oxygen due to surface oxidation. After 7 days in vitro culture, the complete adhesion pattern of the rat MSCs was obtained on the irradiated SR at dose of 1×1015 ions/cm2, corresponding to the low contact angle of 87°. At low dose, the partial pattern on the irradiated region was observed instead.

  10. Analysis of the pattern of urine loss in women with incontinence as measured by weighing perineal pads.

    Science.gov (United States)

    Sutherst, J R; Brown, M C; Richmond, D

    1986-06-01

    Three hundred and thirty-five women with urinary incontinence underwent a pad-weighing test for quantifying urine loss. Each one wore a series of pre-weighed sanitary towels for a total of 1 h. The pads were weighed again after use. The test results gave information about the severity of the incontinence which was not easy to obtain either from patient interview or from clinical examination. The type of activity was the main factor determining urine loss, although patients with detrusor instability lost more on average than the others. Voiding during the test period did not appear to influence the overall test results. Reproducibility of the test has been studied in 50 patients.

  11. Patterns of copper loss--a comparison of the multiload Cu250, TCu-220C and Cu7 IUDs.

    Science.gov (United States)

    Goh, T H; Tong, S L

    1986-04-01

    The rate of copper loss from 329 IUDs (Multiload Cu250, TCu-220C and Cu7) which had been terminated for various reasons after 0.5-46 months in-utero were determined. All 3 IUDs showed a wide scatter of release rates with no significant differences between the ML Cu250 and the Cu7. The TCu-220C showed the highest rates and in contrast to the ML Cu250 and Cu7, the decrease with time was not significant. Its rate of copper loss was significantly higher than the ML Cu250 in the 1st year, but comparable after that. The TCu-220C had a similar rate to the Cu7 in the 1st year and significantly higher rates subsequently. The relevance of these findings to observed pregnancy rates and area of copper on the IUDs is discussed.

  12. A qualitative analysis of the role of emotions in different patterns of long-term weight loss.

    Science.gov (United States)

    Ingels, John Spencer; Zizzi, Sam

    2018-04-04

    To explore participant perspectives of the impact emotions have on weight loss. A qualitative design gathered data through semi-structured interviews with participants in a weight management programme. The interview addresses the following research questions: (1) how do individuals working to lose weight perceive the impact emotions have on their long-term success, and (2) what strategies do more or less successful participants use to regulate their emotions? Researchers conducted and transcribed the interviews then completed content analysis to create and organise themes. Two broad themes emerged through the interviews with 21 participants: emotional impact and emotional regulation. Further subthemes captured emotions blocking action toward goals, strategies for regulating emotions (e.g. exercise, food) and the need for new strategies to regulate emotions. Themes were also split in to three groups based on weight outcomes: regainer, moderate success (3-6% loss) and large success (>7% loss). More successful participants, compared to regainers, shared being aware of the impact of their emotions and made efforts to develop healthy regulation strategies. Emotional awareness and regulation play an important role in participant's weight management experience. Taking time to build emotional awareness and strategies to manage emotions is important to participants in weight management.

  13. Detection of various anatomic patterns of root canals in mandibular incisors using digital periapical radiography, 3 cone-beam computed tomographic scanners, and micro-computed tomographic imaging.

    Science.gov (United States)

    Paes da Silva Ramos Fernandes, Luciana Maria; Rice, Dwight; Ordinola-Zapata, Ronald; Alvares Capelozza, Ana Lucia; Bramante, Clovis Monteiro; Jaramillo, David; Christensen, Heidi

    2014-01-01

    The purpose of this study was to compare the accuracy of digital periapical (PA) radiography and 3 cone-beam computed tomographic (CBCT) scanners in the identification of various internal anatomic patterns in mandibular incisors. Forty mandibular incisors were scanned using micro-computed tomographic imaging as the gold standard to establish the internal anatomic pattern. The number of root canals and internal patterns were classified into type I (single canal, n = 12), type Ia (single oval canal, n = 12), and type III (2 canals, n = 16). The teeth were placed in a human mandible, and digital PA radiography and 3 CBCT scans (Kodak 9000 3D [Carestream Health, Rochester, NY], Veraviewepocs 3De [J Morita MFG Corp, Kyoto, Japan], NewTom 5G [QR Srl, Verona, Italy]) were performed. Two blinded examiners classified each tooth's anatomic pattern, which were then compared with the micro-computed tomographic determinations. Considering type I and type Ia, which both presented with 1 root canal, there was a high degree of accuracy for all methods used (P > .05). The same result was found for type III. When identifying the shape of single canals (type I), CBCT imaging was more accurate compared with PA radiography. Concerning oval canals (type Ia), there was a significant difference between PA radiography and NewTom CBCT (PA radiography = 44%, NewTom = 88%). However, there were no significant differences between the 3 CBCT units. Double-exposure digital PA radiography for mandibular incisors is sufficient for the identification of the number of root canals. All CBCT devices showed improved accuracy in the identification of single root canal anatomy when a narrow canal was present. However, the identification of oval canals was improved only with the NewTom CBCT device. Copyright © 2014 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  14. A Formal Approach to the Selection by Minimum Error and Pattern Method for Sensor Data Loss Reduction in Unstable Wireless Sensor Network Communications.

    Science.gov (United States)

    Kim, Changhwa; Shin, DongHyun

    2017-05-12

    There are wireless networks in which typically communications are unsafe. Most terrestrial wireless sensor networks belong to this category of networks. Another example of an unsafe communication network is an underwater acoustic sensor network (UWASN). In UWASNs in particular, communication failures occur frequently and the failure durations can range from seconds up to a few hours, days, or even weeks. These communication failures can cause data losses significant enough to seriously damage human life or property, depending on their application areas. In this paper, we propose a framework to reduce sensor data loss during communication failures and we present a formal approach to the Selection by Minimum Error and Pattern (SMEP) method that plays the most important role for the reduction in sensor data loss under the proposed framework. The SMEP method is compared with other methods to validate its effectiveness through experiments using real-field sensor data sets. Moreover, based on our experimental results and performance comparisons, the SMEP method has been validated to be better than others in terms of the average sensor data value error rate caused by sensor data loss.

  15. [Two cases of stroke associated with the use of finasteride, an approved drug for male-pattern hair loss in Japan].

    Science.gov (United States)

    Tsuji, Yukio; Nakayama, Takahiro; Bono, Keiko; Kitamura, Mizuki; Imafuku, Ichiro

    2014-01-01

    We report two cases of stroke associated with the use of finasteride at 1 mg/day, which is approved in Japan for the treatment of male-pattern hair loss. The first case involved a 35-year-old male taking 1 mg of finasteride daily for 6 months to prevent male-pattern hair loss. He was taken to a hospital and later admitted to our hospital owing to headache and seizures. Brain computed tomography (CT) images showed a low-density area in the right frontal lobe. CT venography (CTV) revealed sinus thrombosis and he was treated with an anticoagulant. As the headache gradually subsided, medications were tapered and terminated 10 months later when venous flow to the sagittal sinus and left transverse sinus was confirmed to be recanalized. The second case involved a 41-year-old male taking 1 mg of finasteride and 6 mg of minoxidil daily for 1 year for male-pattern hair loss. He started having headaches and was admitted to our hospital when diffusion-weighted images of brain magnetic resonance imaging (MRI) showed a high-intensity area in the left parietotemporal lobe. He was treated with antiplatelet and anticoagulation medicines. The Japan Pharmaceutical and Medical Devices Agency (PMDA) has reported 14 cases of thrombosis in patients taking finasteride in Japan; 4 cases of stroke (our 2 cases and 2 reported by PMDA), 6 cases of myocardial infarction, and 4 cases of other thrombotic diseases. Increases in estrone and estradiol levels in prostate cancer patients and controls receiving 5 mg of finasteride have been reported. Gynecomastia has also been reported as one of the adverse effects of finasteride at 1 mg or 5 mg daily. Taken together, we assume that the increases in estrone and estradiol levels induced by finasteride lead to thrombosis development.

  16. Specific diurnal EMG activity pattern observed in occlusal collapse patients: relationship between diurnal bruxism and tooth loss progression.

    Directory of Open Access Journals (Sweden)

    Shigehisa Kawakami

    Full Text Available AIM: The role of parafunctional masticatory muscle activity in tooth loss has not been fully clarified. This study aimed to reveal the characteristic activity of masseter muscles in bite collapse patients while awake and asleep. MATERIALS AND METHODS: Six progressive bite collapse patients (PBC group, six age- and gender-matched control subjects (MC group, and six young control subjects (YC group were enrolled. Electromyograms (EMG of the masseter muscles were continuously recorded with an ambulatory EMG recorder while patients were awake and asleep. Diurnal and nocturnal parafunctional EMG activity was classified as phasic, tonic, or mixed using an EMG threshold of 20% maximal voluntary clenching. RESULTS: Highly extended diurnal phasic activity was observed only in the PBC group. The three groups had significantly different mean diurnal phasic episodes per hour, with 13.29±7.18 per hour in the PBC group, 0.95±0.97 per hour in the MC group, and 0.87±0.98 per hour in the YC group (p<0.01. ROC curve analysis suggested that the number of diurnal phasic episodes might be used to predict bite collapsing tooth loss. CONCLUSION: Extensive bite loss might be related to diurnal masticatory muscle parafunction but not to parafunction during sleep. CLINICAL RELEVANCE SCIENTIFIC RATIONALE FOR STUDY: Although mandibular parafunction has been implicated in stomatognathic system breakdown, a causal relationship has not been established because scientific modalities to evaluate parafunctional activity have been lacking. PRINCIPAL FINDINGS: This study used a newly developed EMG recording system that evaluates masseter muscle activity throughout the day. Our results challenge the stereotypical idea of nocturnal bruxism as a strong destructive force. We found that diurnal phasic masticatory muscle activity was most characteristic in patients with progressive bite collapse. PRACTICAL IMPLICATIONS: The incidence of diurnal phasic contractions could be used for

  17. Assessing electron beam sensitivity for SrTiO{sub 3} and La{sub 0.7}Sr{sub 0.3}MnO{sub 3} using electron energy loss spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Nord, Magnus, E-mail: magnunor@gmail.com [Department of Physics, NTNU, Trondheim (Norway); Vullum, Per Erik [Department of Physics, NTNU, Trondheim (Norway); Materials and Chemistry, SINTEF, Trondheim (Norway); Hallsteinsen, Ingrid; Tybell, Thomas [Department of Electronics and Telecommunications, NTNU, Trondheim (Norway); Holmestad, Randi [Department of Physics, NTNU, Trondheim (Norway)

    2016-10-15

    Thresholds for beam damage have been assessed for La{sub 0.7}Sr{sub 0.3}MnO{sub 3} and SrTiO{sub 3} as a function of electron probe current and exposure time at 80 and 200 kV acceleration voltage. The materials were exposed to an intense electron probe by aberration corrected scanning transmission electron microscopy (STEM) with simultaneous acquisition of electron energy loss spectroscopy (EELS) data. Electron beam damage was identified by changes of the core loss fine structure after quantification by a refined and improved model based approach. At 200 kV acceleration voltage, damage in SrTiO{sub 3} was identified by changes both in the EEL fine structure and by contrast changes in the STEM images. However, the changes in the STEM image contrast as introduced by minor damage can be difficult to detect under several common experimental conditions. No damage was observed in SrTiO{sub 3} at 80 kV acceleration voltage, independent of probe current and exposure time. In La{sub 0.7}Sr{sub 0.3}MnO{sub 3}, beam damage was observed at both 80 and 200 kV acceleration voltages. This damage was observed by large changes in the EEL fine structure, but not by any detectable changes in the STEM images. The typical method to validate if damage has been introduced during acquisitions is to compare STEM images prior to and after spectroscopy. Quantifications in this work show that this method possibly can result in misinterpretation of beam damage as changes of material properties. - Highlights: • We studied the effects of a TEM electron beam on a perovskite heterostructure. • Using an improved ELNES quantification method, subtle changes could be observed. • On LSMO changes were observed in the ELNES, but none in the STEM-HAADF. • For STO changes were observed in both ELNES and STEM-HAADF. • This shows beam damage can be misinterpreted as material properties.

  18. Terascale Beam-Beam Simulations for Tevatron, RHIC and LHC

    Energy Technology Data Exchange (ETDEWEB)

    Qiang, J.

    2005-05-16

    In this paper, we report on recent advances in terascale simulations of the beam-beam interaction in Tevatron, RHIC and LHC.Computational methods for self consistent calculation of beam-beam forces are reviewed. New method for solving the two-dimensional Poisson equation with open boundary conditions is proposed and tested. This new spectral-finite difference method is a factor of four faster than the widely used FFT based Green function method for beam-beam interaction on axis. We also present applications to the study of antiproton losses during the injection stage at Tevatron, to the study of multiple bunch coherent beam-beam modes at RHIC, and to the study of beam-beam driven emittance growth at LHC.

  19. Terascale Beam-Beam Simulations for Tevatron, RHIC and LHC

    International Nuclear Information System (INIS)

    Qiang, J.

    2005-01-01

    In this paper, we report on recent advances in terascale simulations of the beam-beam interaction in Tevatron, RHIC and LHC.Computational methods for self consistent calculation of beam-beam forces are reviewed. New method for solving the two-dimensional Poisson equation with open boundary conditions is proposed and tested. This new spectral-finite difference method is a factor of four faster than the widely used FFT based Green function method for beam-beam interaction on axis. We also present applications to the study of antiproton losses during the injection stage at Tevatron, to the study of multiple bunch coherent beam-beam modes at RHIC, and to the study of beam-beam driven emittance growth at LHC

  20. Beam diagnostics for low energy beams

    Directory of Open Access Journals (Sweden)

    J. Harasimowicz

    2012-12-01

    Full Text Available Low-energetic ion and antimatter beams are very attractive for a number of fundamental studies. The diagnostics of such beams, however, is a challenge due to low currents down to only a few thousands of particles per second and significant fraction of energy loss in matter at keV beam energies. A modular set of particle detectors has been developed to suit the particular beam diagnostic needs of the ultralow-energy storage ring (USR at the future facility for low-energy antiproton and ion research, accommodating very low beam intensities at energies down to 20 keV. The detectors include beam-profile monitors based on scintillating screens and secondary electron emission, sensitive Faraday cups for absolute intensity measurements, and capacitive pickups for beam position monitoring. In this paper, the design of all detectors is presented in detail and results from beam measurements are shown. The resolution limits of all detectors are described and options for further improvement summarized. Whilst initially developed for the USR, the instrumentation described in this paper is also well suited for use in other low-intensity, low-energy accelerators, storage rings, and beam lines.

  1. Electron Beam Lithography

    Science.gov (United States)

    Harriott, Lloyd R.

    1997-04-01

    Electron beams have played a significant role in semiconductor technology for more than twenty years. Early electron beam machines used a raster scanned beam spot to write patterns in electron-sensitive polymer resist materials. The main application of electron beam lithography has been in mask making. Despite the inherently high spatial resolution and wide process margins of electron beam lithography, the writing rate for semiconductor wafers has been too slow to be economically viable on a large scale. In the late 1970's, variable shape electron beam writing was developed, projecting a rectangular beam whose size can be varied for each "shot" exposure of a particular pattern, allowing some integrated circuits to be made economically where a variety of "customized" patterns are desired. In the cell or block projection electron beam exposure technique, a unit cell of a repetitive pattern is projected repeatedly to increase the level of parallelism. This can work well for highly repetitive patterns such as memory chips but is not well suited to complex varying patterns such as microprocessors. The rapid progress in the performance of integrated circuits has been largely driven by progress in optical lithography, through improvements in lens design and fabrication as well as the use of shorter wavelengths for the exposure radiation. Due to limitations from the opacity of lens and mask materials, it is unlikely that conventional optical printing methods can be used at wavelengths below 193 nm or feature sizes much below 180 nm. One candidate technology for a post-optical era is the Scattering with Angular Limitation Projection Electron-beam Lithography (SCALPEL) approach, which combines the high resolution and wide process latitude inherent in electron beam lithography with the throughput of a parallel projection system. A mask consisting of a low atomic number membrane and a high atomic number pattern layer is uniformly illuminated with high energy (100 ke

  2. Exposure parameters in proton beam writing for hydrogen silsesquioxane

    International Nuclear Information System (INIS)

    Kan, J.A. van; Zhang, F.; Zhang, C.; Bettiol, A.A.; Watt, F.

    2008-01-01

    In proton beam writing (PBW) a focused MeV proton beam is scanned in a predetermined pattern over a resist (e.g. PMMA, SU-8 or HSQ), which is subsequently chemically developed. In e-beam writing as well as p-beam writing the energy loss of the primary beam is dominated by energy transfer to substrate electrons. Unlike the high energy secondary electrons generated during e-beam writing the secondary electrons induced by the primary proton beam have low energy and therefore a limited range, resulting in minimal proximity effects. The low proximity effects exhibited by p-beam writing coupled with the straight trajectory and high penetration of the proton beam enables the production of high aspect ratio, high density 3D micro and nanostructures with well defined smooth side walls to be directly written into resist materials. This property together with the stability and focusing power of the end station ensures even exposures with nm smoothness and allows fabrication of details down to the 20 nm level. In this paper, we present results like contrast and sensitivity for PBW using, hydrogen silsesquioxane (HSQ) and XR-1541, both are non-C based resists. Unlike PMMA and SU-8 resist HSQ shows aging effects, requiring optimized processing parameters in PBW

  3. Resistance of virus to extinction on bottleneck passages: Study of a decaying and fluctuating pattern of fitness loss

    Science.gov (United States)

    Lázaro, Ester; Escarmís, Cristina; Pérez-Mercader, Juan; Manrubia, Susanna C.; Domingo, Esteban

    2003-01-01

    RNA viruses display high mutation rates and their populations replicate as dynamic and complex mutant distributions, termed viral quasispecies. Repeated genetic bottlenecks, which experimentally are carried out through serial plaque-to-plaque transfers of the virus, lead to fitness decrease (measured here as diminished capacity to produce infectious progeny). Here we report an analysis of fitness evolution of several low fitness foot-and-mouth disease virus clones subjected to 50 plaque-to-plaque transfers. Unexpectedly, fitness decrease, rather than being continuous and monotonic, displayed a fluctuating pattern, which was influenced by both the virus and the state of the host cell as shown by effects of recent cell passage history. The amplitude of the fluctuations increased as fitness decreased, resulting in a remarkable resistance of virus to extinction. Whereas the frequency distribution of fitness in control (independent) experiments follows a log-normal distribution, the probability of fitness values in the evolving bottlenecked populations fitted a Weibull distribution. We suggest that multiple functions of viral genomic RNA and its encoded proteins, subjected to high mutational pressure, interact with cellular components to produce this nontrivial, fluctuating pattern. PMID:12960384

  4. Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a

    Directory of Open Access Journals (Sweden)

    Lisette Lange

    2017-06-01

    Full Text Available The mouse t haplotype, a variant 20 cM genomic region on Chromosome 17, harbors 16 embryonic control genes identified by recessive lethal mutations isolated from wild mouse populations. Due to technical constraints so far only one of these, the tw5 lethal, has been cloned and molecularly characterized. Here we report the molecular isolation of the tw18 lethal. Embryos carrying the tw18 lethal die from major gastrulation defects commencing with primitive streak formation at E6.5. We have used transcriptome and marker gene analyses to describe the molecular etiology of the tw18 phenotype. We show that both WNT and Nodal signal transduction are impaired in the mutant epiblast, causing embryonic patterning defects and failure of primitive streak and mesoderm formation. By using a candidate gene approach, gene knockout by homologous recombination and genetic rescue, we have identified the gene causing the tw18 phenotype as Ppp2r1a, encoding the PP2A scaffolding subunit PR65alpha. Our work highlights the importance of phosphatase 2A in embryonic patterning, primitive streak formation, gastrulation, and mesoderm formation downstream of WNT and Nodal signaling.

  5. Up-to-date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss.

    Science.gov (United States)

    Shin, Hyoseung; Won, Chong Hyun; Chung, Woon-Kyung; Park, Byung-Soon

    2017-01-01

    The primary roles of mesenchymal stem cells (MSCs) are to maintain the stem cell niche, facilitate recovery after injury, and ensure healthy aging and the homeostasis of organ and tissues. MSCs have recently emerged as a new therapeutic option for hair loss. Since adipose-derived stem cells (ADSCs) are the most accessible sources of MSCs, ADSCbased hair regeneration is investigated. Besides replacing degenerated cells in affected organs, ADSCs exhibit their beneficial effects through the paracrine actions of various cytokines and growth factors. Several laboratory experiments and animal studies have shown that ADSC-related proteins can stimulate hair growth. In addition, we introduce our clinical pilot studies using conditioned media of ADSCs for pattern hair loss in men and women. We believe that conditioned media of ADSCs represents a promising alternative therapeutic strategy for hair loss. We also discuss practical therapeutic challenges and the direction of future research. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  6. Specific diurnal EMG activity pattern observed in occlusal collapse patients: relationship between diurnal bruxism and tooth loss progression.

    Science.gov (United States)

    Kawakami, Shigehisa; Kumazaki, Yohei; Manda, Yosuke; Oki, Kazuhiro; Minagi, Shogo

    2014-01-01

    The role of parafunctional masticatory muscle activity in tooth loss has not been fully clarified. This study aimed to reveal the characteristic activity of masseter muscles in bite collapse patients while awake and asleep. Six progressive bite collapse patients (PBC group), six age- and gender-matched control subjects (MC group), and six young control subjects (YC group) were enrolled. Electromyograms (EMG) of the masseter muscles were continuously recorded with an ambulatory EMG recorder while patients were awake and asleep. Diurnal and nocturnal parafunctional EMG activity was classified as phasic, tonic, or mixed using an EMG threshold of 20% maximal voluntary clenching. Highly extended diurnal phasic activity was observed only in the PBC group. The three groups had significantly different mean diurnal phasic episodes per hour, with 13.29±7.18 per hour in the PBC group, 0.95±0.97 per hour in the MC group, and 0.87±0.98 per hour in the YC group (pstability.

  7. A scaling aneurysm model-based approach to assessing the role of flow pattern and energy loss in aneurysm rupture prediction.

    Science.gov (United States)

    Long, Yunling; Zhong, Jingru; Yu, Hongyu; Yan, Huagang; Zhuo, Zhizheng; Meng, Qianqian; Yang, Xinjian; Li, Haiyun

    2015-09-22

    Energy loss (EL) was regarded to be one of the key parameters in predicting the rupture risk of IA. In this paper, we took varied aspect ratio (AR) as a scaling law to create a series of longitudinal models to investigate the longitudinal changes of flow pattern and EL as the AR varies, in order to explore the relationship between the longitudinal characteristic EL parameters with aneurysm rupture risk. Seven original intracranial aneurysms (IA) models with similar locations were reconstructed from patient 3D rotational angiography (3DRA) images. Based on these models, a series of scaling aneurysm models with different ARs were created with our proposed scaling algorithms. Fluid-solid interaction (FSI) simulations were performed on every model to obtain hemodynamics flow pattern and EL. With AR increasing, flow pattern became more complex, with vortices appearing gradually in the aneurysms (AR > 1.5). Furthermore, the velocity significantly decreased in aneurysms with high ARs (>1.5). Meanwhile, the aneurysm EL increased with increasing AR. Once AR exceeded 1.5, EL changed drastically. EL was a potential parameter predicting future rupture of unruptured aneurysms. If the EL during the growth of the unruptured aneurysms increased sharply, we strongly recommend an intervention.

  8. Coherent instabilities of a relativistic bunched beam

    International Nuclear Information System (INIS)

    Chao, A.W.

    1982-06-01

    A charge-particle beam contained in an accelerator vacuum chamber interacts electromagnetically with its environment to create a wake field. This field than acts back on the beam, perturbing the particle motion. If the beam intensity is high enough, this beam-environment interaction may lead to an instability and to subsequent beam loss. The beam and its environment form a dynamical system, and it is this system that will be studied. 84 references

  9. Coherent instabilities of a relativistic bunched beam

    Energy Technology Data Exchange (ETDEWEB)

    Chao, A.W.

    1982-06-01

    A charge-particle beam contained in an accelerator vacuum chamber interacts electromagnetically with its environment to create a wake field. This field than acts back on the beam, perturbing the particle motion. If the beam intensity is high enough, this beam-environment interaction may lead to an instability and to subsequent beam loss. The beam and its environment form a dynamical system, and it is this system that will be studied. 84 references.

  10. Dual-beam CRT

    International Nuclear Information System (INIS)

    1975-01-01

    A dual-beam cathode-ray tube having a pair of electron guns and associated deflection means disposed side-by-side on each side of a central axis is described. The electron guns are parallel and the deflection means includes beam centering plates and angled horizontal deflection plates to direct the electron beams toward the central axis, precluding the need for a large-diameter tube neck in which the entire gun structures are angled. Bowing control plates are disposed adjacent to the beam centering plates to minimize trace bowing, and an intergun shield is disposed between the horizontal deflection plates to control and correct display pattern geometry distortion

  11. Myopic loss aversion revisited

    OpenAIRE

    Blavatskyy, Pavlo; Pogrebna, Ganna

    2009-01-01

    In this paper we reexamine several experimental papers on myopic loss aversion by analyzing individual rather than aggregate choice patterns. We find that the behavior of the majority of subjects is inconsistent with the hypothesis of myopic loss aversion.

  12. Beam-beam observations in the Relativistic Heavy Ion Collider

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Y. [Brookhaven National Laboratory (BNL), Upton, NY (United States); Fischer, W. [Brookhaven National Laboratory (BNL), Upton, NY (United States); White, S. [Brookhaven National Laboratory (BNL), Upton, NY (United States)

    2015-06-24

    The Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory has been operating since 2000. Over the past decade, thanks to the continuously increased bunch intensity and reduced β*s at the interaction points, the maximum peak luminosity in the polarized proton operation has been increased by more than two orders of magnitude. In this article, we first present the beam-beam observations in the previous RHIC polarized proton runs. Then we analyze the mechanisms for the beam loss and emittance growth in the presence of beam-beam interaction. The operational challenges and limitations imposed by beam-beam interaction and their remedies are also presented. In the end, we briefly introduce head-on beam-beam compensation with electron lenses in RHIC.

  13. BEAM HALO FORMATION IN HIGH-INTENSITY BEAMS.

    Energy Technology Data Exchange (ETDEWEB)

    FEDOTOV, A.V.

    2005-03-18

    Studies of beam halo became unavoidable feature of high-intensity machines where uncontrolled beam loss should be kept to extremely small level. For a well controlled stable beam such a loss is typically associated with the low density halo surrounding beam core. In order to minimize uncontrolled beam loss or improve performance of an accelerator, it is very important to understand what are the sources of halo formation in a specific machine of interest. The dominant mechanisms are, in fact, different in linear accelerators, circular machines or Energy Recovering Linacs (ERL). In this paper, we summarize basic mechanisms of halo formation in high-intensity beams and discuss their application to various types of accelerators of interest, such as linacs, rings and ERL.

  14. Comparison of Threshold Saccadic Vector Optokinetic Perimetry (SVOP) and Standard Automated Perimetry (SAP) in Glaucoma. Part II: Patterns of Visual Field Loss and Acceptability.

    Science.gov (United States)

    McTrusty, Alice D; Cameron, Lorraine A; Perperidis, Antonios; Brash, Harry M; Tatham, Andrew J; Agarwal, Pankaj K; Murray, Ian C; Fleck, Brian W; Minns, Robert A

    2017-09-01

    We compared patterns of visual field loss detected by standard automated perimetry (SAP) to saccadic vector optokinetic perimetry (SVOP) and examined patient perceptions of each test. A cross-sectional study was done of 58 healthy subjects and 103 with glaucoma who were tested using SAP and two versions of SVOP (v1 and v2). Visual fields from both devices were categorized by masked graders as: 0, normal; 1, paracentral defect; 2, nasal step; 3, arcuate defect; 4, altitudinal; 5, biarcuate; and 6, end-stage field loss. SVOP and SAP classifications were cross-tabulated. Subjects completed a questionnaire on their opinions of each test. We analyzed 142 (v1) and 111 (v2) SVOP and SAP test pairs. SVOP v2 had a sensitivity of 97.7% and specificity of 77.9% for identifying normal versus abnormal visual fields. SAP and SVOP v2 classifications showed complete agreement in 54% of glaucoma patients, with a further 23% disagreeing by one category. On repeat testing, 86% of SVOP v2 classifications agreed with the previous test, compared to 91% of SAP classifications; 71% of subjects preferred SVOP compared to 20% who preferred SAP. Eye-tracking perimetry can be used to obtain threshold visual field sensitivity values in patients with glaucoma and produce maps of visual field defects, with patterns exhibiting close agreement to SAP. Patients preferred eye-tracking perimetry compared to SAP. This first report of threshold eye tracking perimetry shows good agreement with conventional automated perimetry and provides a benchmark for future iterations.

  15. Femtosecond laser-assisted keratoplasty: full and partial-thickness cut wound strength and endothelial cell loss across a variety of wound patterns.

    Science.gov (United States)

    Kopani, Kamden R; Page, Michael A; Holiman, Jeff; Parodi, Armando; Iliakis, Bernie; Chamberlain, Winston

    2014-07-01

    To evaluate wound strength for patient safety during transport and endothelial viability when partial and complete femtosecond laser-assisted keratoplasty (FLAK) incisions are made in cadaveric corneas. 19 human corneoscleral rims were divided into six groups, mounted on an anterior chamber maintainer and cut with a femtosecond laser programmed to the following patterns: 'zigzag' (A), 'mushroom' (B) and 'top hat' (C) in both full (1) and partial (2) thicknesses. The pressure required to produce leakage from the corneal incision was then measured. Eight additional corneas were cut with the 'zigzag' pattern: four full and four partial thickness, prepared and transported per standard eye bank protocol, and analysed for endothelial cell loss with trypan blue staining and digital image analysis. Mean leakage pressure in mm Hg for group A1 was 110 (SD 94); group A2, 1180 (SD 468); group B1, 978 (SD 445); group B2, 987 (SD 576); group C1, 710 (SD 474); group C2, 1290 (SD 231). There was a significant difference in leakage pressure between groups A1 and A2 (p=0.05), groups A1 and B1 (p=0.05), and groups A1 and C1 (p=0.05). Mean percentage endothelial damage after full-thickness cuts was 8.40 (SD 2.34) and 5.30 (SD 1.33) in partial-thickness cuts (p=0.11). Partial thickness zigzag, top hat and mushroom-style partial FLAK incisions left an intact tissue wall with high resistance to rupture, whereas full-thickness cuts were more variable. Laser trephination and eye bank handling protocol for donor FLAK buttons leads to moderate peripheral endothelial cell loss in tissue with both complete and partial cuts.

  16. Evolution of plastid gene rps2 in a lineage of hemiparasitic and holoparasitic plants: Many losses of photosynthesis and complex patterns of rate variation

    Science.gov (United States)

    dePamphilis, Claude W.; Young, Nelson D.; Wolfe, Andrea D.

    1997-01-01

    The plastid genomes of some nonphotosynthetic parasitic plants have experienced an extreme reduction in gene content and an increase in evolutionary rate of remaining genes. Nothing is known of the dynamics of these events or whether either is a direct outcome of the loss of photosynthesis. The parasitic Scrophulariaceae and Orobanchaceae, representing a continuum of heterotrophic ability ranging from photosynthetic hemiparasites to nonphotosynthetic holoparasites, are used to investigate these issues. We present a phylogenetic hypothesis for parasitic Scrophulariaceae and Orobanchaceae based on sequences of the plastid gene rps2, encoding the S2 subunit of the plastid ribosome. Parasitic Scrophulariaceae and Orobanchaceae form a monophyletic group in which parasitism can be inferred to have evolved once. Holoparasitism has evolved independently at least five times, with certain holoparasitic lineages representing single species, genera, and collections of nonphotosynthetic genera. Evolutionary loss of the photosynthetic gene rbcL is limited to a subset of holoparasitic lineages, with several holoparasites retaining a full length rbcL sequence. In contrast, the translational gene rps2 is retained in all plants investigated but has experienced rate accelerations in several hemi- as well as holoparasitic lineages, suggesting that there may be substantial molecular evolutionary changes to the plastid genome of parasites before the loss of photosynthesis. Independent patterns of synonymous and nonsynonymous rate acceleration in rps2 point to distinct mechanisms underlying rate variation in different lineages. Parasitic Scrophulariaceae (including the traditional Orobanchaceae) provide a rich platform for the investigation of molecular evolutionary process, gene function, and the evolution of parasitism. PMID:9207097

  17. Cross sections of electron loss and capture for beams of O+ in water vapor from the energy range of 0,2 to 1,2 MeV

    International Nuclear Information System (INIS)

    Oliveira, Vitor Jesus de

    2015-01-01

    The study of the interactions between atoms and molecules is important for the knowledge of the cross sections of the processes that contribute to the deposition of energy by charged particle beams used in radiotherapy planning and transport particle simulation codes. Heavy ions, such as oxygen, induce many cellular and molecular damages in human cells.as a result of interaction between the projectile and atoms and molecules. The use of proton and carbon as the projectile interacting with water molecules is well characterized, however there are few studies with oxygen ions. In this work we are interested in the study of electron loss (projectile ionization) and electron capture with charge state 1+. The Pelletron accelerator of 1.7 MeV from the Federal University of Rio de Janeiro housed in the Atomic and Molecular collisions Laboratory (LACAM) has been used, which can accelerate atomic and molecular ions up to speeds of the order of hundredths of light speed, and consists of the source of negative ions, the Wien filter, the accelerator itself and the magnet load selector. The detection device used to evaluate the processes of interaction (capture and loss) between the beam of the O + and the water molecule is a Microchannel Plate (MCP) at the position sensitive anode. The collisions of O + beans are being studied in the range of 0.2 to 1.2 MeV with water vapor (Z = 10). Were obtained the respective absolute cross sections for electron loss and electron capture and compared with the cross sections of the molecule methane (CH4 → Z = 10), the isoelectronic water molecule. The experimental results show an agreement between the measurements with water and methane. Comparisons were made with results of theoretical models for electron loss using the 'Free Collision Model' and for capture the Bohr and Lindhard model. The theoretical results for electron loss show an agreement of experimental data with the model used. The model of Bohr and Lindhard describes

  18. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication

    Directory of Open Access Journals (Sweden)

    Sato Yukuto

    2009-06-01

    Full Text Available Abstract Background Recent genomic studies have revealed a teleost-specific third-round whole genome duplication (3R-WGD event occurred in a common ancestor of teleost fishes. However, it is unclear how the genes duplicated in this event were lost or persisted during the diversification of teleosts, and therefore, how many of the duplicated genes contribute to the genetic differences among teleosts. This subject is also important for understanding the process of vertebrate evolution through WGD events. We applied a comparative evolutionary approach to this question by focusing on the genes involved in long-term potentiation, taste and olfactory transduction, and the tricarboxylic acid cycle, based on the whole genome sequences of four teleosts; zebrafish, medaka, stickleback, and green spotted puffer fish. Results We applied a state-of-the-art method of maximum-likelihood phylogenetic inference and conserved synteny analyses to each of 130 genes involved in the above biological systems of human. These analyses identified 116 orthologous gene groups between teleosts and tetrapods, and 45 pairs of 3R-WGD-derived duplicate genes among them. This suggests that more than half [(45×2/(116+45] = 56.5% of the loci, probably more than ten thousand genes, present in a common ancestor of the four teleosts were still duplicated after the 3R-WGD. The estimated temporal pattern of gene loss suggested that, after the 3R-WGD, many (71/116 of the duplicated genes were rapidly lost during the initial 75 million years (MY, whereas on average more than half (27.3/45 of the duplicated genes remaining in the ancestor of the four teleosts (45/116 have persisted for about 275 MY. The 3R-WGD-derived duplicates that have persisted for a long evolutionary periods of time had significantly larger number of interacting partners and longer length of protein coding sequence, implying that they tend to be more multifunctional than the singletons after the 3R-WGD. Conclusion

  19. Spatial and temporal patterns of spontaneous grass cover as a control measure of soil loss: a study case in an olive orchard microcatchment

    Science.gov (United States)

    Taguas, Encarnación; Vanderlinden, Karl; Pedrera-Parrilla, Aura; Giráldez, Juan V.; Gómez, Jose A.

    2016-04-01

    Spatial and temporal patterns of vegetal communities control local biogeophysical processes.. The use of cover crops and spontaneous grass cover as a soil erosion control measure is quite common, particularly in hilly agricultural areas. Spontaneous covers show usually irregular spatial and temporal patterns, resulting in a questionable efficiency and and unresolved management requirements. However, due to its zero cost, it is a helpful alternative for soil erosion control in marginal farms (Taguas et al., 2015). The main aim of this work was to characterize the spatial and temporal patterns of spontaneous grass cover in an olive orchard microcatchment to interpret its dependences on other physical features as well as its influence on soil loss control. The specific objectives were: i) to evaluate the relationships between the mean cover and the variables: accumulated precipitation, accumulated evapotranspiration and average minimum temperature for the preceding 5, 15, 30 and 60 days to the sampling date; ii) study the spatial aggregation degree of the cover, its temporal stability and its correlation with different topographical properties, the richness of species and the apparent electrical conductivity as a measure of soil variability; and iii) describe the influence of the cover on runoff and soil loss in the catchments. Cover percentage corresponding to spontaneous grass was evaluated on a seaonsal basis during 3 years (2011-2013), resulting in 12 surveys. A permanent and regular grid of 36 points covering the entire catchment (5-6 samples/ha) was used in each survey. At each location cover percentage was determined through image analyses. In order to explore the relations between cover percentage and meteorological variables, multiple linear regression was applied whereas the SADIE approach (Spatial analysis by distance indices; Perry, 1998) was used to describe possible spatial aggregation patterns and the correlation with features such as aspect, slope

  20. Evaluation of diagnostic accuracy of conventional and digital periapical radiography, panoramic radiography, and cone-beam computed tomography in the assessment of alveolar bone loss

    OpenAIRE

    Wilton Mitsunari Takeshita; Lilian Cristina Vessoni Iwaki; Mariliani Chicarelli Da Silva; Renata Hernandes Tonin

    2014-01-01

    Background: To evaluate the diagnostic accuracy of different radiographic methods in the assessment of proximal alveolar bone loss (ABL). Materials and Methods: ABL, the distance between cement-enamel junction and alveolar bone crest, was measured in 70 mandibular human teeth - directly on the mandibles (control), using conventional periapical radiography with film holders (Rinn XCP and Han-Shin), digital periapical radiography with complementary metal-oxide semiconductor sensor, conventional...

  1. Time dependent formulation of the energy loss by an accelerated intense electron beam just emitted by the cathode of RF-FEL photoinjector

    Energy Technology Data Exchange (ETDEWEB)

    Salah, Wa' el [Physics Department, Hashemite University, Zarqa 13115 (Jordan)]. E-mail: wael_salahh@hotmail.com; Coacolo, J.-L. [Institut de Physique Nucleaire d' Orsay, 91406 Orsay Cedex (France); Hallak, A.B. [Physics Department, Hashemite University, Zarqa 13115 (Jordan); Al-Obaid, M. [Physics Department, Hashemite University, Zarqa 13115 (Jordan)

    2006-08-01

    The energy loss by an accelerated electron bunch of a conical shape propagating in the laser-driven RF-photoinjector is expressed in terms of an expansion of the vector and scalar potentials into a series of eigenfunctions of the empty unit 'pill-box' cavity. A versatile and simple analytical formula which can be easily applied to a bunch of any shape is obtained.

  2. Cyclotrons for high-intensity beams

    CERN Document Server

    Seidel, Mike

    2013-01-01

    This paper reviews the important physical and technological aspects of cyclotrons for the acceleration of high-intensity beams. Special emphasis is given to the discussion of beam loss mechanisms and extraction schemes.

  3. Characteristics of microdomains and microdomain patterns recorded by electron beam irradiation on Y-cut LiNbO3 crystals

    Science.gov (United States)

    Kokhanchik, L. S.; Gainutdinov, R. V.; Lavrov, S. D.; Volk, T. R.

    2015-08-01

    We present the results of investigations of planar domain patterns (isolated domains and domain gratings) fabricated by irradiation of the nonpolar Y-surface of LiNbO3 crystals by an electron beam (EB) incident normally onto the surface. The EB recorded domains were investigated using atomic force microscopy, confocal second harmonic generation microscopy, and chemical etching as an auxiliary method. The dependence of the domain characteristics on irradiation conditions (acceleration voltage U, EB current I, and irradiation time tirr) were determined. The length Ld of both isolated domains and domain gratings along the polar axis Z grows linearly with tirr (at U, I = const) with no tending to saturation. The plots Ld(tirr) obtained for U = 10 and 15 kV are practically identical, whereas the values of Ld for U = 5 kV are essentially lower. The domain thickness Td along the Y-direction, i.e., the depth of the switched layer grows with acceleration voltage U. These results are discussed in terms of space-charge fields formation arising under EB irradiation of insulators. The linearity of Ld(tirr) is accounted for by the frontal domain growth via the viscous friction law. The experimental dependence of Td on U supports the suggestion that the domain thickness is determined by the penetration depth Re of primary electrons, which in turn is governed by U. The difference in Ld(tirr) plots for different U is accounted for by different electron emission σ. Indirect evidences of a defect structure modification in a thin surface layer with respect to the crystal bulk are obtained.

  4. Study of beam-beam long range compensation with octupoles

    CERN Document Server

    AUTHOR|(CDS)2068329; Pieloni, Tatiana; Buffat, Xavier; Tambasco, Claudia

    2017-01-01

    Long range beam-beam effects are responsible for particle losses and define fundamental operational parameters of colliders (i.e. crossing angles, intensities, emittances, ${\\beta}$${^∗}$). In this study we propose octuple magnets as a possible scheme to efficiently compensate long-range beam-beam interactions with a global correction scheme. The impact and improvements on the dynamic aperture of colliding beams together with estimates of the luminosity potentials are dis- cussed for the HL-LHC upgrade and extrapolations made for the FCC project.

  5. Limitations due to strong head-on beam-beam interactions (MD 1434)

    CERN Document Server

    Buffat, Xavier; Iadarola, Giovanni; Papadopoulou, Parthena Stefania; Papaphilippou, Yannis; Pellegrini, Dario; Pojer, Mirko; Crockford, Guy; Salvachua Ferrando, Belen Maria; Trad, Georges; Barranco Garcia, Javier; Pieloni, Tatiana; Tambasco, Claudia; CERN. Geneva. ATS Department

    2017-01-01

    The results of an experiment aiming at probing the limitations due to strong head on beam-beam interactions are reported. It is shown that the loss rates significantly increase when moving the working point up and down the diagonal, possibly due to effects of the 10th and/or 14th order resonances. Those limitations are tighter for bunches with larger beam-beam parameters, a maximum total beam-beam tune shift just below 0.02 could be reached.

  6. Coherent beam-beam effects

    International Nuclear Information System (INIS)

    Chao, A.W.

    1992-01-01

    There are two physical pictures that describe the beam-beam interaction in a storage ring collider: The weak-strong and the strong-strong pictures. Both pictures play a role in determining the beam-beam behavior. This review addresses only the strong-strong picture. The corresponding beam dynamical effects are referred to as the coherent beam-beam effects. Some basic knowledge of the weak-strong picture is assumed. To be specific, two beams of opposite charges are considered. (orig.)

  7. Electron beams in radiation therapy

    International Nuclear Information System (INIS)

    Bruinvis, I.A.D.

    1987-01-01

    Clinical electron beams in interaction with beam flattening and collimating devices are studied, in order to obtain the means for adequate electron therapy. A treatment planning method for arbitrary field shapes is developed that takes the properties of the collimated electron beams into account. An electron multiple-scattering model is extended to incorporate a model for the loss of electrons with depth, in order to improve electron beam dose planning. A study of ionisation measurements in two different phantom materials yields correction factors for electron beam dosimetry. (Auth.)

  8. Superresolution beams

    CSIR Research Space (South Africa)

    Ngcobo, S

    2011-11-01

    Full Text Available zones capable of introducing a phase shift of zero or p on the alternately out of phase rings of the TEMp0 beams into a unified phase and then focusing the rectified beam to generate a high resolution beam which has a Gaussian beam intensity distribution...

  9. WORKSHOP: Crystalline beams

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    Following pioneer work by specialists at the Soviet Novosibirsk Laboratory some ten years ago, interest developed in the possibility of 'freezing' ion beams in storage rings by pushing cooling (to smooth out beam behaviour) to its limits, the final goal being to lock the ions into a neat crystal pattern. After advances by groups working on laser cooled ions in traps, and with several cooling rings now in operation, a workshop on crystalline ion beams was organized recently by the GSI (Darmstadt) Laboratory and held at Wertheim in Germany

  10. Clinical efficacy of oral administration of finasteride at a dose of 2.5 mg/day in women with female pattern hair loss.

    Science.gov (United States)

    Won, Yong-Yon; Lew, Bark-Lynn; Sim, Woo-Young

    2018-03-01

    Female pattern hair loss (FPHL) presents with diffuse thinning over the mid-frontal scalp, for which various treatment modalities have been tried. Although currently, oral 5 α-reductase inhibitors such as finasteride are being used, their clinical efficacy remains controversial. We retrospectively investigated 544 premenopausal or postmenopausal patients with FPHL who were prescribed finasteride at a dose of 2.5 mg/day. Our study excluded patients with a follow-up period of < 3 months and patients who were prescribed other FPHL treatment modalities including topical minoxidil. Finally, 112 patients were evaluated based on their medical records and clinical photographs. Based on assessment using the Ludwig scale at the time of their initial visit, among 112 patients studied, 59 patients were classified as belonging to grade I, 47 were grade II, and 6 were grade III. Using global photographs, we found that 33 (29.5%) of the 112 patients studied showed slight improvement, 73 (65.2%) showed significant improvement, whereas no change was recorded in 6 (5.4%). We could demonstrate efficacy of administration of finasteride at a dose of 2.5 mg/day for patients with FPHL and also found that finasteride has a better effect on hair growth when patients had a lower Ludwig score and an older age at onset. © 2018 Wiley Periodicals, Inc.

  11. Structure and evolution of the drainage system of a Himalayan debris-covered glacier, and its relationship with patterns of mass loss

    Science.gov (United States)

    Benn, Douglas I.; Thompson, Sarah; Gulley, Jason; Mertes, Jordan; Luckman, Adrian; Nicholson, Lindsey

    2017-09-01

    We provide the first synoptic view of the drainage system of a Himalayan debris-covered glacier and its evolution through time, based on speleological exploration and satellite image analysis of Ngozumpa Glacier, Nepal. The drainage system has several linked components: (1) a seasonal subglacial drainage system below the upper ablation zone; (2) supraglacial channels, allowing efficient meltwater transport across parts of the upper ablation zone; (3) sub-marginal channels, allowing long-distance transport of meltwater; (4) perched ponds, which intermittently store meltwater prior to evacuation via the englacial drainage system; (5) englacial cut-and-closure conduits, which may undergo repeated cycles of abandonment and reactivation; and (6) a "base-level" lake system (Spillway Lake) dammed behind the terminal moraine. The distribution and relative importance of these elements has evolved through time, in response to sustained negative mass balance. The area occupied by perched ponds has expanded upglacier at the expense of supraglacial channels, and Spillway Lake has grown as more of the glacier surface ablates to base level. Subsurface processes play a governing role in creating, maintaining, and shutting down exposures of ice at the glacier surface, with a major impact on spatial patterns and rates of surface mass loss. Comparison of our results with observations on other glaciers indicate that englacial drainage systems play a key role in the response of debris-covered glaciers to sustained periods of negative mass balance.

  12. Efficacy and Safety of Minoxidil 2% Solution in Combination With a Botanical Hair Solution in Women With Female Pattern Hair Loss/Androgenic Alopecia.

    Science.gov (United States)

    McMichael, Amy; Pham, Hanh; von Grote, Erika; Meckfessel, Matthew H

    2016-04-01

    Female pattern hair loss (FPHL), also known as female androgenic alopecia, affects over 21 million women in the United States with devastating effects on self-esteem and psychosocial functioning. Topical minoxidil 2% and 5% formulations are the only US Food and Drug Administration-approved treatments for FPHL. The length of time it typically takes to observe the benefits is a challenge for many patients, and may affect adherence to treatment. Herbal extracts, which are also believed to promote healthier-looking hair, have a long history of use in hair care formulations. The safety and efficacy of a twice-daily regimen of 2% minoxidil solution used in combination with the botanical hair solution for 12 weeks in 54 subjects was evaluated in a multicenter, single-arm, open-label study. Assessments included investigator and subject ratings of improvement and subject satisfaction. Investigator ratings indicated significant improvement in hair growth and overall treatment benefits in as early as 6 weeks (Pminoxidil treatment adherence.

  13. Citation patterns of a controversial and high-impact paper: Worm et al. (2006) "Impacts of biodiversity loss on ocean ecosystem services".

    Science.gov (United States)

    Branch, Trevor A

    2013-01-01

    Citation patterns were examined for Worm et al. 2006 (Science 314:787-790), a high-impact paper that focused on relationships between marine biodiversity and ecosystem services. This paper sparked much controversy through its projection, highlighted in the press release, that all marine fisheries would be collapsed by 2048. Analysis of 664 citing papers revealed that only a small percentage (11%) referred to the 2048 projection, while 39% referred to fisheries collapse in general, and 40% to biodiversity and ecosystem services. The 2048 projection was mentioned more often in papers published soon after the original paper, in low-impact journals, and in journals outside of fields that would be expected to focus on biodiversity. Citing papers also mentioned the 2048 projection more often if they had few authors (28% of single-author papers vs. 2% of papers with 10 or more authors). These factors suggest that the more knowledgeable the authors of citing papers were about the controversy over the 2048 projection, the less likely they were to refer to it. A noteworthy finding was that if the original authors were also involved in the citing papers, they rarely (1 of 55 papers, 2%) mentioned the 2048 projection. Thus the original authors have emphasized the broader concerns about biodiversity loss, rather than the 2048 projection, as the key result of their study.

  14. Citation patterns of a controversial and high-impact paper: Worm et al. (2006 "Impacts of biodiversity loss on ocean ecosystem services".

    Directory of Open Access Journals (Sweden)

    Trevor A Branch

    Full Text Available Citation patterns were examined for Worm et al. 2006 (Science 314:787-790, a high-impact paper that focused on relationships between marine biodiversity and ecosystem services. This paper sparked much controversy through its projection, highlighted in the press release, that all marine fisheries would be collapsed by 2048. Analysis of 664 citing papers revealed that only a small percentage (11% referred to the 2048 projection, while 39% referred to fisheries collapse in general, and 40% to biodiversity and ecosystem services. The 2048 projection was mentioned more often in papers published soon after the original paper, in low-impact journals, and in journals outside of fields that would be expected to focus on biodiversity. Citing papers also mentioned the 2048 projection more often if they had few authors (28% of single-author papers vs. 2% of papers with 10 or more authors. These factors suggest that the more knowledgeable the authors of citing papers were about the controversy over the 2048 projection, the less likely they were to refer to it. A noteworthy finding was that if the original authors were also involved in the citing papers, they rarely (1 of 55 papers, 2% mentioned the 2048 projection. Thus the original authors have emphasized the broader concerns about biodiversity loss, rather than the 2048 projection, as the key result of their study.

  15. BATMAN beam properties characterization by the beam emission spectroscopy diagnostic

    Energy Technology Data Exchange (ETDEWEB)

    Bonomo, F., E-mail: federica.bonomo@igi.cnr.it [Consorzio RFX (CNR, ENEA, INFN, Università di Padova, Acciaierie Venete SpA), Corso Stati Uniti 4, 35127 Padova (Italy); Istituto Gas Ionizzati - CNR, Corso Stati Uniti 4, 35127 Padova (Italy); Ruf, B.; Schiesko, L.; Fantz, U.; Franzen, P.; Riedl, R.; Wünderlich, D. [Max-Planck-Institut für Plasmaphysik, Boltzmannstr. 2, 85748 Garching (Germany); Barbisan, M.; Pasqualotto, R.; Serianni, G. [Consorzio RFX (CNR, ENEA, INFN, Università di Padova, Acciaierie Venete SpA), Corso Stati Uniti 4, 35127 Padova (Italy); Cristofaro, S. [Universitá degli Studi di Padova, Via 8 Febbraio 2, 35122 Padova (Italy)

    2015-04-08

    The ITER neutral beam heating systems are based on the production and acceleration of negative ions (H/D) up to 1 MV. The requirements for the beam properties are strict: a low core beam divergence (< 0.4 °) together with a low source pressure (≤ 0.3 Pa) would permit to reduce the ion losses along the beamline, keeping the stripping particle losses below 30%. However, the attainment of such beam properties is not straightforward. At IPP, the negative ion source testbed BATMAN (BAvarian Test MAchine for Negative ions) allows for deepening the knowledge of the determination of the beam properties. One of the diagnostics routinely used to this purpose is the Beam Emission Spectroscopy (BES): the H{sub α} light emitted in the beam is detected and the corresponding spectra are evaluated to estimate the beam divergence and the stripping losses. The BES number of lines of sight in BATMAN has been recently increased: five horizontal lines of sight providing a vertical profile of the beam permit to characterize the negative ion beam properties in relation to the source parameters. Different methods of H{sub α} spectra analysis are here taken into account and compared for the estimation of the beam divergence and the amount of stripping. In particular, to thoroughly study the effect of the space charge compensation on the beam divergence, an additional hydrogen injection line has been added in the tank, which allows for setting different background pressure values (one order of magnitude, from about 0.04 Pa up to the source pressure) in the beam drift region.

  16. Beam-beam and impedance

    CERN Document Server

    White, S.

    2014-07-17

    As two counter-rotating beams interact they can give rise to coherent dipole modes. Under the influence of impedance these coherent beam-beam modes can couple to higher order head-tail modes and lead to strong instabilities. A fully self-consistent approach including beam-beam and impedance was used to characterize this new coupled mode instability and study possible cures such as a transverse damper and high chromaticity.

  17. Coherent Beam-Beam Effects in the LHC

    CERN Document Server

    Alexahin, Yu I; Herr, Werner; Zorzano-Mier, M P

    2001-01-01

    In the Large Hadron Collider (LHC) two proton beams of similar intensities collide in several interaction points. It is well known that the head-on collision of two beams of equal strength can excite coherent modes whose frequencies are separated from the incoherent spectrum of oscillations of individual particles. This can lead to the loss of Landau damping and possibly to unstable motion. The beam-beam effect in the LHC is further complicated by a large number of bunches (2808 per beam), a finite crossing angle and gaps in the bunch train. The coherent beam-beam effects under various conditions and operational scenarios are studied analytically and with multiparticle simulations. We give an overview of the main results and present proposals to overcome these difficulties together with possible side effects.

  18. Durnin-Whitney beams

    Science.gov (United States)

    de Jesús Cabrera-Rosas, Omar; Espíndola-Ramos, Ernesto; Alejandro Juárez-Reyes, Salvador; Julián-Macías, Israel; Ortega-Vidals, Paula; Rickenstorff-Parrao, Carolina; Silva-Ortigoza, Gilberto; Silva-Ortigoza, Ramón; Sosa-Sánchez, Citlalli Teresa

    2017-05-01

    The aim of the present work is to define a Durnin-Whitney beam as a nondiffracting beam such that its associated caustic locally only has singularities of the fold and cusp types. Since the caustic is structurally stable then the intensity pattern of this beam is also stable and this property is what makes its definition and its theoretical and experimental study worthwhile. These properties are important in applications such as uniform optical drilling in waveguides and communications through weak turbulent atmosphere. We find that in accordance with Whitney's theorem on the stability of maps from a two-dimensional manifold to a two-dimensional manifold the phase g({{Φ }}), of the complex function A({{Φ }}) characterizing the beam, locally is given by g({{Φ }})=a{{Φ }} for a fold and g({{Φ }})=b{{{Φ }}}2 for a cusp. This result implies that the Bessel beam of order zero is not stable and that any other Bessel beam is stable because locally it has a caustic of fold type. Finally, we present an example of a Durnin-Whitney beam given by g({{Φ }})=m{{Φ }}+b{{{Φ }}}2, which is a natural generalization of the Bessel beam of order m with a singularity of cusp ridge type.

  19. BATMAN beam properties characterization by the beam emission spectroscopy diagnostic

    Science.gov (United States)

    Bonomo, F.; Ruf, B.; Barbisan, M.; Cristofaro, S.; Schiesko, L.; Fantz, U.; Franzen, P.; Pasqualotto, R.; Riedl, R.; Serianni, G.; Wünderlich, D.

    2015-04-01

    The ITER neutral beam heating systems are based on the production and acceleration of negative ions (H/D) up to 1 MV. The requirements for the beam properties are strict: a low core beam divergence (BATMAN (BAvarian Test MAchine for Negative ions) allows for deepening the knowledge of the determination of the beam properties. One of the diagnostics routinely used to this purpose is the Beam Emission Spectroscopy (BES): the Hα light emitted in the beam is detected and the corresponding spectra are evaluated to estimate the beam divergence and the stripping losses. The BES number of lines of sight in BATMAN has been recently increased: five horizontal lines of sight providing a vertical profile of the beam permit to characterize the negative ion beam properties in relation to the source parameters. Different methods of Hα spectra analysis are here taken into account and compared for the estimation of the beam divergence and the amount of stripping. In particular, to thoroughly study the effect of the space charge compensation on the beam divergence, an additional hydrogen injection line has been added in the tank, which allows for setting different background pressure values (one order of magnitude, from about 0.04 Pa up to the source pressure) in the beam drift region.

  20. Beam dancer fusion device

    International Nuclear Information System (INIS)

    Maier, H.B.

    1984-01-01

    To accomplish fusion of two or more fusion fuel elements numerous minute spots of energy or laser light are directed to a micro target area, there to be moved or danced about by a precision mechanical controlling apparatus at the source of the laser light or electromagnetic energy beams, so that merging and coinciding patterns of light or energy beams can occur around the area of the fuel atoms or ions. The projecting of these merging patterns may be considered as target searching techniques to locate responsive clusters of fuel elements and to compress such elements into a condition in which fusion may occur. Computerized programming may be used

  1. Beam Interlocks for LHC and SPS

    CERN Document Server

    Dinius, A; Gimeno-Vicente, J; Nouchi, P; Puccio, B; Schmidt, R; Wenninger, J

    2003-01-01

    The Large Hadron Collider at CERN (LHC) will operate at 7 TeV/c with a luminosity of 10 cms. This requires two beams with about 3^10 protons/beam, corresponding to a stored energy of about 350 MJ, sufficient to heat and melt 500 kg of copper. Protection of equipment from damage in case of uncontrolled beam losses is challenging. Injection of the beam from the SPS to the LHC could already damage equipment and is only permitted when all LHC systems are correctly prepared. In case of an uncontrolled loss of the circulating LHC beams, it is required to extract the beams into a specially designed target as soon as possible. Beam loss monitors and equipment for hardware surveillance are distributed around the 26 km long accelerator. In case of failures or beam losses, the beam interlock system is informed and sends a dump request to the beam dumping system. The beam interlock system also inhibits injection when the LHC is not ready for beam. In this paper the requirements for the beam interlock system are discussed...

  2. Beam cooling

    OpenAIRE

    Danared, H

    2006-01-01

    Beam cooling is the technique of reducing the momentum spread and increasing the phase-space density of stored particle beams. This paper gives an introduction to beam cooling and Liouville’s theorem, and then it describes the three methods of active beam cooling that have been proven to work so far, namely electron cooling, stochastic cooling, and laser cooling. Ionization cooling is also mentioned briefly.

  3. Molecular beams

    International Nuclear Information System (INIS)

    Pendelbury, J.M.; Smith, K.F.

    1987-01-01

    Studies with directed collision-free beams of particles continue to play an important role in the development of modern physics and chemistry. The deflections suffered by such beams as they pass through electric and magnetic fields or laser radiation provide some of the most direct information about the individual constituents of the beam; the scattering observed when two beams intersect yields important data about the intermolecular forces responsible for the scattering. (author)

  4. Beam Diagnostics for the J-PARC Main Ring Synchrotron

    CERN Document Server

    Toyama, Takeshi; Hashimoto, Yoshinori; Hayashi, Naoki; Kishiro, Junichi; Lee, Seishu; Miura, Takako; Muto, Suguru; Toyokawa, Ryoji

    2005-01-01

    Beam diagnostics: beam intensity monitors (DCCT, SCT, FCT, WCM), beam position monitors (ESM), beam loss monitors (proportional chamber, air ion chamber), beam profile monitors (secondary electron emission, gas-sheet) have been designed, tested, and will be installed for the Main Ring synchrotron of J-PARC (Japan Proton Accelerator Research Complex). This paper describes the basic design principle and specification of each monitor, with a stress on how to cope with high power beam (average circulation current of ~12 A) and low beam loss operation (less than 1 W/m except a collimator region). Some results of preliminary performance test using present beams and a radiation source will be reported.

  5. ADT fast losses MD

    CERN Document Server

    Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

    2013-01-01

    The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

  6. Biomimetic sulfated polyethylene glycol hydrogel inhibits proteoglycan loss and tumor necrosis factor-α-induced expression pattern in an osteoarthritis in vitro model.

    Science.gov (United States)

    Hemmati-Sadeghi, Shabnam; Dey, Pradip; Ringe, Jochen; Haag, Rainer; Sittinger, Michael; Dehne, Tilo

    2018-04-16

    This study aimed to evaluate the potential of an anti-inflammatory polyethylene glycol (PEG) hydrogel for osteoarthritis (OA) management in an OA in vitro model. Freshly isolated porcine chondrocytes were maintained in high-density cultures to form cartilage-like three-dimensional micromasses. Recombinant porcine tumor necrosis factor-alpha (TNF-α) was used to induce OA-like changes. Normal and OA-like micromasses were treated with dendritic polyglycerol sulfate-based PEG hydrogel. Live/dead staining showed that all micromasses remained vital and presented similar morphological characteristics. Safranin-O staining demonstrated a typical depletion of glycosaminoglycans in TNF-α-treated micromasses but not in the presence of the hydrogel. There was no distinct difference in immunohistochemical detection of type II collagen. Microarray data showed that rheumatoid arthritis and TNF signaling pathways were down regulated in hydrogel-treated OA-like micromasses compared to nontreated OA-like micromasses. The hydrogel alone did not affect genes related to OA such as ANPEP, COMP, CXCL12, PTGS2, and TNFSF10, but it prevented their regulation caused by TNF-α. This study provides valuable insights toward a fully synthetic hydrogel for the intra-articular treatment of OA. The findings proved the potential of this hydrogel to prevent the development of TNF-α-induced OA with regard to proteoglycan loss and TNF-α-induced expression pattern without additional signs of differentiation and inflammation. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. © 2018 Wiley Periodicals, Inc.

  7. Beam-beam collisions and crossing angles in RHIC

    International Nuclear Information System (INIS)

    Peggs, S.

    1999-01-01

    This paper evaluates the strength of head on and parasitic beam-beam collisions in RHIC when the crossing angle is zero. A non-zero crossing angle is not required in normal operation with 120 bunches, thanks to the early separation of the two beams. The RHIC lattice is shown to easily accommodate even conservatively large crossing angles, for example in beam dynamics studies, or in future operational upgrades to as many as 360 bunches per ring. A modest loss in luminosity is incurred when gold ions collide at an angle after 10 hours of storage

  8. Low emittance growth in a low energy beam transport line with un-neutralized section

    Science.gov (United States)

    Prost, L.; Carneiro, J.-P.; Shemyakin, A.

    2018-02-01

    In a low energy beam transport line (LEBT), the emittance growth due to the beam's space charge is typically suppressed by way of neutralization from either electrons or ions, which originate from ionization of the background gas. In cases where the beam is chopped, the neutralization pattern usually changes throughout the beginning of the pulse, causing the Twiss parameters to differ significantly from their steady state values, which, in turn, may result in beam losses downstream. For a modest beam perveance, there is an alternative solution, in which the beam is kept un-neutralized in the portion of the LEBT that contains the chopper. The emittance can be nearly preserved if the transition to the un-neutralized section occurs where the beam exhibits low transverse tails. This report introduces the rationale for the proposed scheme and formulates the physical arguments for it as well as its limitations. An experimental realization of the scheme was carried out at Fermilab's PIP2IT where low beam emittance dilution was demonstrated for a 5 mA, 30 keV H- beam.

  9. Phenotypic plasticity of gas exchange pattern and water loss in Scarabaeus spretus (Coleoptera: Scarabaeidae): deconstructing the basis for metabolic rate variation.

    Science.gov (United States)

    Terblanche, John S; Clusella-Trullas, Susana; Chown, Steven L

    2010-09-01

    Investigation of gas exchange patterns and modulation of metabolism provide insight into metabolic control systems and evolution in diverse terrestrial environments. Variation in metabolic rate in response to environmental conditions has been explained largely in the context of two contrasting hypotheses, namely metabolic depression in response to stressful or resource-(e.g. water) limited conditions, or elevation of metabolism at low temperatures to sustain life in extreme conditions. To deconstruct the basis for metabolic rate changes in response to temperature variation, here we undertake a full factorial study investigating the longer- and short-term effects of temperature exposure on gas exchange patterns. We examined responses of traits of gas exchange [standard metabolic rate (SMR); discontinuous gas exchange (DGE) cycle frequency; cuticular, respiratory and total water loss rate (WLR)] to elucidate the magnitude and form of plastic responses in the dung beetle, Scarabaeus spretus. Results showed that short- and longer-term temperature variation generally have significant effects on SMR and WLR. Overall, acclimation to increased temperature led to a decline in SMR (from 0.071+/-0.004 ml CO(2) h(-1) in 15 degrees C-acclimated beetles to 0.039+/-0.004 ml CO(2) h(-1) in 25 degrees C-acclimated beetles measured at 20 degrees C) modulated by reduced DGE frequency (15 degrees C acclimation: 0.554+/-0.027 mHz, 20 degrees C acclimation: 0.257+/-0.030 mHz, 25 degrees C acclimation: 0.208+/-0.027 mHz recorded at 20 degrees C), reduced cuticular WLRs (from 1.058+/-0.537 mg h(-1) in 15 degrees C-acclimated beetles to 0.900+/-0.400 mg h(-1) in 25 degrees C-acclimated beetles measured at 20 degrees C) and reduced total WLR (from 4.2+/-0.5 mg h(-1) in 15 degrees C-acclimated beetles to 3.1+/-0.5 mg h(-1) in 25 degrees C-acclimated beetles measured at 25 degrees C). Respiratory WLR was reduced from 2.25+/-0.40 mg h(-1) in 15 degrees C-acclimated beetles to 1.60+/-0.40 mg h

  10. Beam dynamics issues for linear colliders

    International Nuclear Information System (INIS)

    Ruth, R.D.

    1987-09-01

    In this paper we discuss various beam dynamics issues for linear colliders. The emphasis is to explore beam dynamics effects which lead to an effective dilution of the emittance of the beam and thus to a loss of luminosity. These considerations lead to various tolerances which are evaluated for a particular parameter set

  11. Novel electron beam recording media

    International Nuclear Information System (INIS)

    1974-01-01

    Electron beam recording media comprise a film of an olefin-SO 2 copolymer on a support. Certain of these copolymers give direct print-out relief patterns after exposure to electron beams. The chemical composition and preparation of these layered films is described

  12. Beam diagnostics

    International Nuclear Information System (INIS)

    Bogaty, J.; Clifft, B.E.; Zinkann, G.P.; Pardo, R.C.

    1995-01-01

    The ECR-PII injector beam line is operated at a fixed ion velocity. The platform high voltage is chosen so that all ions have a velocity of 0.0085c at the PII entrance. If a previous tune configuration for the linac is to be used, the beam arrival time must be matched to the previous tune as well. A nondestructive beam-phase pickup detector was developed and installed at the entrance to the PII linac. This device provides continuous phase and beam current information and allows quick optimization of the beam injected into PII. Bunches traverse a short tubular electrode thereby inducing displacement currents. These currents are brought outside the vacuum interface where a lumped inductance resonates electrode capacitance at one of the bunching harmonic frequencies. This configuration yields a basic sensitivity of a few hundred millivolts signal per microampere of beam current. Beam-induced radiofrequency signals are summed against an offset frequency generated by our master oscillator. The resulting kilohertz difference frequency conveys beam intensity and bunch phase information which is sent to separate processing channels. One channel utilizes a phase locked loop which stabilizes phase readings if beam is unstable. The other channel uses a linear full wave active rectifier circuit which converts kilohertz sine wave signal amplitude to a D.C. voltage representing beam current. A prototype set of electronics is now in use with the detector and we began to use the system in operation to set the arrival beam phase. A permanent version of the electronics system for the phase detector is now under construction. Additional nondestructive beam intensity and phase monitors at the open-quotes Boosterclose quotes and open-quotes ATLASclose quotes linac sections are planned as well as on some of the high-energy beam lines. Such a monitor will be particularly useful for FMA experiments where the primary beam hits one of the electric deflector plates

  13. Hearing loss

    Science.gov (United States)

    Decreased hearing; Deafness; Loss of hearing; Conductive hearing loss; Sensorineural hearing loss; Presbycusis ... Conductive hearing loss (CHL) occurs because of a mechanical problem in the outer or middle ear. This may be ...

  14. LHC Beam Instrumentation: Beam Profile Measurements (2/3)

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    The LHC is equipped with a full suite of sophisticated beam instrumentation which has been essential for rapid commissioning, the safe increase in total stored beam power and the understanding of machine optics and accelerator physics phenomena. These lectures will introduce these systems and comment on their contributions to the various stages of beam operation. They will include details on: the beam position system and its use for real-time global orbit feedback; the beam loss system and its role in machine protection; total and bunch by bunch intensity measurements; tune measurement and feedback; diagnostics for transverse beam size measurements, abort gap monitoring and longitudinal density measurements. Issues and problems encountered along the way will also be discussed together with the prospect for future upgrades.

  15. Accelerator physics studies on the effects from an asynchronous beam dump onto the LHC experimental region collimators

    CERN Document Server

    Lari, L; Boccone, V; Bruce, R; Cerutti, F; Rossi, A; Vlachoudis, V; Mereghetti, A; Faus-Golfe, A

    2012-01-01

    Asynchronous beam aborts at the LHC are estimated to occur on average once per year. Accelerator physics studies of asynchronous dumps have been performed at different beam energies and beta-stars. The loss patterns are analyzed in order to identify the losses in particular on the Phase 1 Tertiary Collimators (TCT), since their tungsten-based active jaw insert has a lower damage threshold than the carbon-based other LHC collimators. Settings of the tilt angle of the TCTs are discussed with the aim of reducing the thermal loads on the TCT themselves.

  16. A Phase III, Multicenter, Parallel-Design Clinical Trial to Compare the Efficacy and Safety of 5% Minoxidil Foam Versus Vehicle in Women With Female Pattern Hair Loss.

    Science.gov (United States)

    Bergfeld, Wilma; Washenik, Ken; Callender, Valerie; Zhang, Paul; Quiza, Carlos; Doshi, Uday; Blume-Peytavi, Ulrike

    2016-07-01

    BACKGROUND Female pattern hair loss (FPHL) is a common hair disorder that affects millions of women. A new 5% minoxidil topical foam (MTF) formulation, which does not contain propylene glycol, has been developed. To compare the efficacy and safety of once-daily 5% MTF with vehicle foam for the treatment of FPHL. This was a Phase III, randomized, double-blind, vehicle-controlled, parallel-group, international multicenter trial (17 sites) in women aged at least 18 years with FPHL (grade D3 to D6 on the Savin Density Scale), treated once daily with 5% MTF or vehicle foam for 24 weeks. The co-primary efficacy endpoints were the change from baseline at week 24 in target area hair count (TAHC) and subject assessment of scalp coverage. Also evaluated were TAHC at week 12, expert panel review of hair regrowth at week 24, and change from baseline in total unit area density (TUAD, sum of hair diameters/cm2) at weeks 12 and 24. A total of 404 women were enrolled. At 12 and 24 weeks, 5% MTF treatment resulted in regrowth of 10.9 hairs/cm2 and 9.1 hairs/cm2 more than vehicle foam, respectively (both P<.0001). Improved scalp coverage at week 24 was observed by both subject self-assessment (0.69-point improvement over vehicle foam; P<.0001) and expert panel review (0.36-point improvement over the vehicle foam; P<.0001). TUAD increased by 658 μm/cm2 and 644 μm/cm2 more with 5% MTF than with vehicle foam at weeks 12 and 24, respectively (both P<.0001). MTF was well tolerated. A low incidence of scalp irritation and facial hypertrichosis was observed, with no clinically significant differences between groups. Five percent MTF once daily for 24 weeks was well tolerated and promoted hair regrowth in women with FPHL, resulting in improved scalp coverage and increased hair density compared with vehicle foam. ClinicalTrials.gov identifier: nCT01226459J Drugs Dermatol. 2016;15(7):874-881.

  17. Polarized proton beams

    International Nuclear Information System (INIS)

    Roser, T.

    1995-01-01

    The acceleration of polarized proton beams in circular accelerators is complicated by the presence of numerous depolarizing spin resonances. Careful and tedious minimization of polarization loss at each of these resonances allowed acceleration of polarized proton beams up to 22 GeV. It has been the hope that Siberian Snakes, which are local spin rotators inserted into ring accelerators, would eliminate these resonances and allow acceleration of polarized beams with the same ease and efficiency that is now routine for unpolarized beams. First tests at IUCF with a full Siberian Snake showed that the spin dynamics with a Snake can be understood in detail. The author now has results of the first tests of a partial Siberian Snake at the AGS, accelerating polarized protons to an energy of about 25 GeV. These successful tests of storage and acceleration of polarized proton beams open up new possibilities such as stored polarized beams for internal target experiments and high energy polarized proton colliders

  18. Low-dose patterning of platinum nanoclusters on carbon nanotubes by focused-electron-beam-induced deposition as studied by TEM

    Directory of Open Access Journals (Sweden)

    Xiaoxing Ke

    2013-02-01

    Full Text Available Focused-electron-beam-induced deposition (FEBID is used as a direct-write approach to decorate ultrasmall Pt nanoclusters on carbon nanotubes at selected sites in a straightforward maskless manner. The as-deposited nanostructures are studied by transmission electron microscopy (TEM in 2D and 3D, demonstrating that the Pt nanoclusters are well-dispersed, covering the selected areas of the CNT surface completely. The ability of FEBID to graft nanoclusters on multiple sides, through an electron-transparent target within one step, is unique as a physical deposition method. Using high-resolution TEM we have shown that the CNT structure can be well preserved thanks to the low dose used in FEBID. By tuning the electron-beam parameters, the density and distribution of the nanoclusters can be controlled. The purity of as-deposited nanoclusters can be improved by low-energy electron irradiation at room temperature.

  19. Low-dose patterning of platinum nanoclusters on carbon nanotubes by focused-electron-beam-induced deposition as studied by TEM

    Science.gov (United States)

    Bittencourt, Carla; Bals, Sara; Van Tendeloo, Gustaaf

    2013-01-01

    Summary Focused-electron-beam-induced deposition (FEBID) is used as a direct-write approach to decorate ultrasmall Pt nanoclusters on carbon nanotubes at selected sites in a straightforward maskless manner. The as-deposited nanostructures are studied by transmission electron microscopy (TEM) in 2D and 3D, demonstrating that the Pt nanoclusters are well-dispersed, covering the selected areas of the CNT surface completely. The ability of FEBID to graft nanoclusters on multiple sides, through an electron-transparent target within one step, is unique as a physical deposition method. Using high-resolution TEM we have shown that the CNT structure can be well preserved thanks to the low dose used in FEBID. By tuning the electron-beam parameters, the density and distribution of the nanoclusters can be controlled. The purity of as-deposited nanoclusters can be improved by low-energy electron irradiation at room temperature. PMID:23399584

  20. Three-dimensional fabrication and characterisation of core-shell nano-columns using electron beam patterning of Ge-doped SiO2

    DEFF Research Database (Denmark)

    Gontard, Lionel C.; Jinschek, Joerg R.; Ou, Haiyan

    2012-01-01

    A focused electron beam in a scanning transmission electron microscope (STEM) is used to create arrays of core-shell structures in a specimen of amorphous SiO2 doped with Ge. The same electron microscope is then used to measure the changes that occurred in the specimen in three dimensions using e...... Institute of Physics. [http://dx.doi.org/10.1063/1.4731765]...

  1. Elliptical beams.

    Science.gov (United States)

    Bandres, Miguel A; Gutiérrez-Vega, Julio C

    2008-12-08

    A very general beam solution of the paraxial wave equation in elliptic cylindrical coordinates is presented. We call such a field an elliptic beam (EB). The complex amplitude of the EB is described by either the generalized Ince functions or the Whittaker-Hill functions and is characterized by four parameters that are complex in the most general situation. The propagation through complex ABCD optical systems and the conditions for square integrability are studied in detail. Special cases of the EB are the standard, elegant, and generalized Ince-Gauss beams, Mathieu-Gauss beams, among others.

  2. Ion beams in materials processing and analysis

    CERN Document Server

    Schmidt, Bernd

    2012-01-01

    This book covers ion beam application in modern materials research, offering the basics of ion beam physics and technology and a detailed account of the physics of ion-solid interactions for ion implantation, ion beam synthesis, sputtering and nano-patterning.

  3. Hereditary Hearing Loss.

    Science.gov (United States)

    Tran, LenhAnh P.; Grundfast, Kenneth M.

    1997-01-01

    This article discusses inheritance patterns in hearing loss, epidemiology, clues to genetic causes, locating genes that cause hereditary disorders, genes related to hearing loss disorders in individuals with Usher syndrome, Waardenburg syndrome, Treacher-Collins syndrome, Branchio-oto-renal and Pendred syndromes, and the significance of finding…

  4. Simulation of filter strips influence on runoff and soil and nutrient losses under different rainfall patterns in a small vineyard catchment

    Science.gov (United States)

    Ramos, Maria C.; Benito, Carolina

    2014-05-01

    This work presents the analysis of the influence of filter strips on soil and water losses in a small catchment, whose main land use is grape vines. The watershed was located in the municipality of Piera (Barcelona, Spain). Other crops like olive trees, winter barley and alfalfa were also found, as well as some residential areas. Soil and water losses were simulated using the Soil and Water Assessment Tool (SWAT). The model was calibrated and validated using soil water and runoff data collected in the field during the period May 2010- May 2012. Then, the model was run for the period 2000-2011, which included years with different rainfall amounts and characteristics. Soil losses with and without that soil conservation measure was compared. The annual rainfall recorded during the analysed years ranged from 329.8 to 785 mm with different rainfall distributions within the year. Runoff rates ranged from 17 to 141 mm, which represented respectively 4.7 and 21% of total precipitation. Both extreme situations were recorded in the driest years of the series, with precipitation below the average. Soil losses ranged between 0.31 Mg/ha in the driest year and 13.9 Mg/ha, in the wettest. The simulation of soil losses with the introduction of filter strips 3m width in the vineyards resulted in a reduction of soil losses up to 68% in relation to the situation without that soil conservation measure. This soil loss decrease represented an additional nutrient loss reduction (up to 66% for N_organic, up to 64% of P_organic and between 6.5 and 40% of N_nitrate, depending on rainfall characteristics).

  5. Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study.

    Science.gov (United States)

    Moleres, Adriana; Campión, Javier; Milagro, Fermín I; Marcos, Ascensión; Campoy, Cristina; Garagorri, Jesús M; Gómez-Martínez, Sonia; Martínez, J Alfredo; Azcona-Sanjulián, M Cristina; Martí, Amelia

    2013-06-01

    In recent years, epigenetic markers emerged as a new tool to understand the influence of lifestyle factors on obesity phenotypes. Adolescence is considered an important epigenetic window over a human's lifetime. The objective of this work was to explore baseline changes in DNA methylation that could be associated with a better weight loss response after a multidisciplinary intervention program in Spanish obese or overweight adolescents. Overweight or obese adolescents (n=107) undergoing 10 wk of a multidisciplinary intervention for weight loss were assigned as high or low responders to the treatment. A methylation microarray was performed to search for baseline epigenetic differences between the 2 groups (12 subjects/group), and MALDI-TOF mass spectrometry was used to validate (n=107) relevant CpG sites and surrounding regions. After validation, 5 regions located in or near AQP9, DUSP22, HIPK3, TNNT1, and TNNI3 genes showed differential methylation levels between high and low responders to the multidisciplinary weight loss intervention. Moreover, a calculated methylation score was significantly associated with changes in weight, BMI-SDS, and body fat mass loss after the treatment. In summary, we have identified 5 DNA regions that are differentially methylated depending on weight loss response. These methylation changes may help to better understand the weight loss response in obese adolescents.

  6. Efficacy and Safety of Once-Daily Minoxidil Foam 5% Versus Twice-Daily Minoxidil Solution 2% in Female Pattern Hair Loss: A Phase III, Randomized, Investigator-Blinded Study.

    Science.gov (United States)

    Blume-Peytavi, Ulrike; Shapiro, Jerry; Messenger, Andrew G; Hordinsky, Maria K; Zhang, Paul; Quiza, Carlos; Doshi, Uday; Olsen, Elise A

    2016-07-01

    A once-daily minoxidil topical foam (MTF) has been developed to treat female pattern hair loss. Determine noninferiority of once-daily 5% MTF versus twice-daily 2% minoxidil topical solution (MTS) based on the change from baseline in target area hair count (TAHC) at 24 weeks. In a randomized, phase III trial, women with female pattern hair loss received once-daily 5% MTF (n=161) or twice-daily 2% MTS (n=161) for 52 weeks. Primary endpoint was change from baseline in TAHC at 24 weeks. Secondary endpoint was change from baseline in TAHC at 12 weeks. Exploratory endpoints included change in total unit area density and change in overall scalp coverage. Once-daily 5% MTF increased TAHC from baseline (adjusted mean ± standard error) by 23.9 ± 2.1 hairs/cm2 at week 24. Twice-daily 2% MTS increased TAHC 24.2 ± 2.1 hairs/cm2 at week 24. The treatment difference was -0.3 hairs/cm2 (95% CI = -6.0, 5.4). Since the lower bound of the 95% CI was less than -5.0, the prespecified noninferiority goal was not met. Both treatments were well tolerated. Once-daily 5% MTF and twice-daily 2% MTS induced hair regrowth in female pattern hair loss, but prespecified noninferiority criteria were not met. ClinicalTrials.gov identifier: NCT01145625 J Drugs Dermatol. 2016;15(7):883-889.

  7. Nanodot and nanocrystal pattern formation and luminescent properties of BiB{sub 3}O{sub 6} glasses after moderate energy ion beam sputtering

    Energy Technology Data Exchange (ETDEWEB)

    Plaza, J.L., E-mail: joseluis.plaza@uam.es [Laboratorio de Crecimiento de Cristales, Dpto. de Fisica de Materiales, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid (Spain); Martinez, O., E-mail: oscar@fmc.uva.es [GdS-Optronlab, Dpto. Fisica Materia Condensada, Universidad de Valladolid, Edificio I-D, Paseo de Belen 1, 47011 Valladolid (Spain); Hortelano, V., E-mail: vhorsan@gmail.com [GdS-Optronlab, Dpto. Fisica Materia Condensada, Universidad de Valladolid, Edificio I-D, Paseo de Belen 1, 47011 Valladolid (Spain); Bensalah, H., E-mail: bensalahhakima@yahoo.fr [Laboratorio de Crecimiento de Cristales, Dpto. de Fisica de Materiales, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid (Spain); Dieguez, E., E-mail: ernesto.dieguez@uam.es [Laboratorio de Crecimiento de Cristales, Dpto. de Fisica de Materiales, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid (Spain)

    2012-02-01

    In this work we study the nanopatterning effect on the surface of BIBO glasses by means of Ion Beam Sputtering (IBS), using moderate energy (<5 kV) Ar ions. The analysis, changing the energy of the Ar ions, has demonstrated the formation of nanodots, nanorripples, and nanopyramids. We have also analysed the dependence of the nanopatterns on the sample thickness for the same experimental conditions. The sizes of the nanodots have been analysed by AFM, while their optical properties studied by means of {mu}-Raman/{mu}-photoluminescence techniques.

  8. Beam halo studies in LEHIPA DTL

    Science.gov (United States)

    Roy, S.; Pande, R.; Rao, S. V. L. S.; Krishnagopal, S.; Singh, P.

    2015-11-01

    The Low Energy High Intensity Proton Accelerator (LEHIPA) project at Bhabha Atomic Research Centre (BARC) consists of a 20 MeV, 30 mA proton linac. The accelerator comprises of a 3 MeV Radio Frequency Quadrupole (RFQ) and a 20 MeV Drift Tube Linac (DTL). In such high intensity accelerators, beam halos are of concern as they not only cause an increase in emittance, but also lead to beam loss and radio activation. We have studied the effect of beam mismatch at the DTL input on halo formation and propagation. The particle core model is used to excite the three envelope eigen modes; the quadrupole mode, the fast mode and the slow mode by giving input beam mismatch. These modes get damped as the beam progresses through the DTL. The damping mechanism is clearly Landau damping and leads to increase in rms emittance of the beam. The evolution of these modes and the corresponding increase in beam emittance and maximum beam extent, as the beam propagates through the DTL, has been studied for different space charge tunes. The halo parameter based on the definition of Allen and Wangler has been calculated. It is seen that beam halos are very important for LEHIPA DTL, even at 20 MeV and leads to emittance and beam size increase and also to beam loss in some cases. The longitudinal halo is present even without mismatch and transverse halos arise in the presence of beam mismatch.

  9. Stationary nonlinear Airy beams

    International Nuclear Information System (INIS)

    Lotti, A.; Faccio, D.; Couairon, A.; Papazoglou, D. G.; Panagiotopoulos, P.; Tzortzakis, S.; Abdollahpour, D.

    2011-01-01

    We demonstrate the existence of an additional class of stationary accelerating Airy wave forms that exist in the presence of third-order (Kerr) nonlinearity and nonlinear losses. Numerical simulations and experiments, in agreement with the analytical model, highlight how these stationary solutions sustain the nonlinear evolution of Airy beams. The generic nature of the Airy solution allows extension of these results to other settings, and a variety of applications are suggested.

  10. Sharp transition from ripple patterns to a flat surface for ion beam erosion of Si with simultaneous co-deposition of iron

    Directory of Open Access Journals (Sweden)

    K. Zhang

    2012-09-01

    Full Text Available We investigate pattern formation on Si by sputter erosion under simultaneous co-deposition of Fe atoms, both at off-normal incidence, as function of the Fe surface coverage. The patterns obtained for 5 keV Xe ion irradiation at 30° incidence angle are analyzed with atomic force microscopy. Rutherford backscattering spectroscopy of the local steady state Fe content of the Fe-Si surface layer allows a quantitative correlation between pattern type and Fe coverage. With increasing Fe coverage the patterns change, starting from a flat surface at low coverage (1.8×1016 Fe/cm2. Our results confirm the observations by Macko et al. for 2 keV Kr ion irradiation of Si with Fe co-deposition. In particular, we also find a sharp transition from pronounced ripple patterns with large amplitude (rms roughness ∼ 18 nm to a rather flat surface (rms roughness ∼ 0.5 nm. Within this transition regime, we also observe the formation of pill bug structures, i.e. individual small hillocks with a rippled structure on an otherwise rather flat surface. The transition occurs within a very narrow regime of the steady state Fe surface coverage between 1.7 and 1.8×1016 Fe/cm2, where the composition of the mixed Fe-Si surface layer of about 10 nm thickness reaches the stoichiometry of FeSi2. Phase separation towards amorphous iron silicide is assumed as the major contribution for the pattern formation at lower Fe coverage and the sharp transition from ripple patterns to a flat surface.

  11. Use of beam deflection to control an electron beam wire deposition process

    Science.gov (United States)

    Taminger, Karen M. (Inventor); Hofmeister, William H. (Inventor); Hafley, Robert A. (Inventor)

    2013-01-01

    A method for controlling an electron beam process wherein a wire is melted and deposited on a substrate as a molten pool comprises generating the electron beam with a complex raster pattern, and directing the beam onto an outer surface of the wire to thereby control a location of the wire with respect to the molten pool. Directing the beam selectively heats the outer surface of the wire and maintains the position of the wire with respect to the molten pool. An apparatus for controlling an electron beam process includes a beam gun adapted for generating the electron beam, and a controller adapted for providing the electron beam with a complex raster pattern and for directing the electron beam onto an outer surface of the wire to control a location of the wire with respect to the molten pool.

  12. Tuning the beam: a physics perspective on beam diagnostic instrumentation

    Energy Technology Data Exchange (ETDEWEB)

    Gulley, Mark S [Los Alamos National Laboratory

    2010-01-01

    In a nutshell, the role of a beam diagnostic measurement is to provide information needed to get a particle beam from Point A (injection point) to Point B (a target) in a useable condition, with 'useable' meaning the right energy and size and with acceptable losses. Specifications and performance requirements of diagnostics are based on the physics of the particle beam to be measured, with typical customers of beam parameter measurements being the accelerator operators and accelerator physicists. This tutorial will be a physics-oriented discussion of the interplay between tuning evolutions and the beam diagnostics systems that support the machine tune. This will include the differences between developing a tune and maintaining a tune, among other things. Practical longitudinal and transverse tuning issues and techniques from a variety of proton and electron machines will also be discussed.

  13. Beam loading effects for two-beam ring

    International Nuclear Information System (INIS)

    Wang Lanfa; Lin Yuzheng; Tong Dechun

    1999-01-01

    An analytic treatment of multi-bunch potential well distortion for a two-beam storage ring is presented. The longitudinal wake effects are separated into: the mode loss, the synchrotron tune shift (both due to potential well distortion) and the coherent multi-bunch coupling. Here, only the first two effects are studied. Resulting simple analytic formulas describe the mode loss and the synchrotron tune shift experienced by a given bunch within the two-beam, as a function of the high order mode's parameters. One can get immediately a simple quantitative answer in term of the mode loss and the synchrotron tune shift experienced by each bunch from these formulas, so the authors can know how to modify the existing configuration of parasitic cavity resonance (via frequency tuning) so that the resulting potential well distortion effects are minimized. When the RF cavities are symmetrically distributed about the interaction points, the two beams will have same beam loading effects, so the authors can compensate the phase shift of the two beam using the same method as in one beam case

  14. Nanoparticle Photoresists: Ligand Exchange as a New, Sensitive EUV Patterning Mechanism

    KAUST Repository

    Kryask, Marie

    2013-01-01

    Hybrid nanoparticle photoresists and their patterning using DUV, EUV, 193 nm lithography and e-beam lithography has been investigated and reported earlier. The nanoparticles have demonstrated very high EUV sensitivity and significant etch resistance compared to other standard photoresists. The current study aims at investigating and establishing the underlying mechanism for dual tone patterning of these nanoparticle photoresist systems. Infrared spectroscopy and UV absorbance studies supported by mass loss and dissolution studies support the current model. © 2013SPST.

  15. Oxide nanoparticle EUV resists: toward understanding the mechanism of positive and negative tone patterning

    KAUST Repository

    Chakrabarty, Souvik

    2013-04-01

    DUV, EUV and e-beam patterning of hybrid nanoparticle photoresists have been reported previously by Ober and coworkers. The present work explores the underlying mechanism that is responsible for the dual tone patterning capability of these photoresist materials. Spectroscopic results correlated with mass loss and dissolution studies suggest a ligand exchange mechanism responsible for altering the solubility between the exposed and unexposed regions. © 2013 SPIE.

  16. SU-E-T-175: A Study on Design and Fabrication of 25 * 25 cm2 Beam Monitor for Scanning Carbon Beam.

    Science.gov (United States)

    Lee, H; Yang, T; Kim, C; Jang, H; Hong, S; Kim, H; Kim, J; Park, D; Kim, C

    2012-06-01

    The KHIMA is developing a superconducting cyclotron of 430 MeV/u for carbon therapy. In order to verify the irradiated beam dose and position, detectors have been developed. The detector has a considered in the active area of 25*25cm 2 to cover the entire beam scanning area. To minimize the loss of data during beam irradiation, a fast data acquisition system was required. A PPIC type was adopted. To measure the beam position and profile, the electrode of PPIC was designed to have a strip pattern. The PCB technique was applied to large area with thin FR-4 plate of electrodes. The chamber has a strip interval of 1.7mm. He was used as the filling gas in order to reduce the ion collection time. Output signal from the detector connected to the two charge integrators was transferred every 10us. The signal can be stored temporarily in memory of FPGA through one of 2 integrators. The fabricated large electrode plates did not show any deformation on their shape. Depending on the beam position, the amount of dose from the ion chamber will be measured. For fast data acquisition, the DAQ board was fabricated by using 2 charge integrators and the FPGA. The obtained data from the ion chamber was displaced on the PC screen every 10us. The fluence map of a single layer will be shown on the PC screen at the end of beam irradiation on the layer. The output data from the profile monitor will be compared with Gafchromic Film results. PCB method for active area of thin electrodes was used in the strip pattern. To reduce the loss of data during irradiation, 2 charge integrators are used alternately. The response of the readout data was set 1 0us. The beam tests will be performed with the MC-50 Cyclotron. © 2012 American Association of Physicists in Medicine.

  17. Dynamic array generation and pattern formation for optical tweezers

    DEFF Research Database (Denmark)

    Mogensen, P.C.; Glückstad, J.

    2000-01-01

    The generalised phase contrast approach is used for the generation of optical arrays of arbitrary beam shape, suitable for applications in optical tweezers for the manipulation of biological specimens. This approach offers numerous advantages over current techniques involving the use of computer-......-generated holograms or diffractive optical elements. We demonstrate a low-loss system for generating intensity patterns suitable for the trapping and manipulation of small particles or specimens....

  18. Applications of electron lenses: scraping of high-power beams, beam-beam compensation, and nonlinear optics

    Energy Technology Data Exchange (ETDEWEB)

    Stancari, Giulio

    2014-09-11

    Electron lenses are pulsed, magnetically confined electron beams whose current-density profile is shaped to obtain the desired effect on the circulating beam. Electron lenses were used in the Fermilab Tevatron collider for bunch-by-bunch compensation of long-range beam-beam tune shifts, for removal of uncaptured particles in the abort gap, for preliminary experiments on head-on beam-beam compensation, and for the demonstration of halo scraping with hollow electron beams. Electron lenses for beam-beam compensation are being commissioned in the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory (BNL). Hollow electron beam collimation and halo control were studied as an option to complement the collimation system for the upgrades of the Large Hadron Collider (LHC) at CERN; a conceptual design was recently completed. Because of their electric charge and the absence of materials close to the proton beam, electron lenses may also provide an alternative to wires for long-range beam-beam compensation in LHC luminosity upgrade scenarios with small crossing angles. At Fermilab, we are planning to install an electron lens in the Integrable Optics Test Accelerator (IOTA, a 40-m ring for 150-MeV electrons) as one of the proof-of-principle implementations of nonlinear integrable optics to achieve large tune spreads and more stable beams without loss of dynamic aperture.

  19. Intra-beam Scattering Theory and RHIC Experiments

    International Nuclear Information System (INIS)

    Wei, J.; Fedotov, A.; Fischer, W.; Malitsky, N.; Parzen, G.; Qiang, J.

    2005-01-01

    Intra-beam scattering is the leading mechanism limiting the luminosity in heavy-ion storage rings like the Relativistic Heavy Ion Collider (RHIC). The multiple Coulomb scattering among the charged particles causes transverse emittance growth and longitudinal beam de-bunching and beam loss, compromising machine performance during collision. Theoretically, the original theories developed by Piwinski, Bjorken, and Mtingwa only describe the rms beam size growth of an unbounded Gaussian distribution. Equations based on the Fokker-Planck approach are developed to further describe the beam density profile evolution and beam loss. During the 2004 RHIC heavy-ion operation, dedicated IBS experiments were performed to bench-mark the rms beam size growth, beam loss, and profile evolution both for a Gaussian-like and a longitudinal hollow beam. This paper summarizes the IBS theory and discusses the experimental bench-marking results

  20. Differences in patterns of allelic loss between two common types of adult cancer, breast and colon carcinoma, and Wilms' tumor of childhood

    NARCIS (Netherlands)

    Devilee, P.; van den Broek, M.; Mannens, M.; Slater, R.; Cornelisse, C. J.; Westerveld, A.; Khan, P. M.

    1991-01-01

    Several chromosomal regions exhibit loss of heterozygosity (LOH) in different types of human tumor, and on this basis are presumed to carry-suppressor genes. We studied 7 of such chromosome regions, including 3p, 5q, 11p, 13q, 17p, 18q and 22q, using a selected set of DNA markers in 44 Wilms'

  1. Different pattern of allelic loss in Epstein-Barr virus-positive gastric cancer with emphasis on the p53 tumor suppressor pathway

    NARCIS (Netherlands)

    van Rees, Bastiaan P.; Caspers, Eric; zur Hausen, Axel; van den Brule, Adriaan; Drillenburg, Paul; Weterman, Marian A. J.; Offerhaus, G. Johan A.

    2002-01-01

    Both Helicobacter pylori (HP) and Epstein-Barr virus (EBV) have been implicated in carcinogenesis of the stomach. Fifty-seven gastric carcinomas were tested for microsatellite instability and allelic loss at several tumor suppressor loci using 21 polymorphic microsatellite markers. Furthermore,

  2. The corrosion pattern of reinforcement and its influence on serviceability of reinforced concrete members in chloride environment

    International Nuclear Information System (INIS)

    Zhang Ruijin; Castel, Arnaud; Francois, Raoul

    2009-01-01

    This paper deals with two corroded reinforcement concrete beams, which have been stored under sustained load in a chloride environment for 14 and 23 years respectively. The evolution of corrosion pattern of reinforcement and its influence on serviceability are studied. In chloride-induced corrosion process, corrosion cracking affects significantly the corrosion pattern. During the corrosion cracking initiation period, only local pitting corrosion occurs. At early stage of cracking propagation, localized pitting corrosion is still predominant as cracks widths are very small and cracks are not interconnected, but a general corrosion slowly develops as the cracks widen. At late cracking stage, interconnected cracking with wide width develops along large parts of the beam leading to a general corrosion pattern. Macrocells and microcells concepts are used for the interpretation of the results. Mechanical experiments and corrosion simulation tests are performed to clarify the influence of this corrosion pattern evolution on the serviceability of the beams (deflection increase). Experimental results show that, when the corrosion is localized (early cracking stage), the steel-concrete bond loss is the main factor affecting the beams serviceability. The local cross-section loss resulting from pitting attack does not significantly influence the deflection of the beam. When corrosion is generalized (late cracking stage), as the steel-concrete bond is already lost, the generalized steel cross-section reduction becomes the main factor affecting the beams serviceability. But, at this stage, the deflection increase is slower due to the low general corrosion rate.

  3. Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial.

    Science.gov (United States)

    Gardner, Christopher D; Trepanowski, John F; Del Gobbo, Liana C; Hauser, Michelle E; Rigdon, Joseph; Ioannidis, John P A; Desai, Manisha; King, Abby C

    2018-02-20

    Dietary modification remains key to successful weight loss. Yet, no one dietary strategy is consistently superior to others for the general population. Previous research suggests genotype or insulin-glucose dynamics may modify the effects of diets. To determine the effect of a healthy low-fat (HLF) diet vs a healthy low-carbohydrate (HLC) diet on weight change and if genotype pattern or insulin secretion are related to the dietary effects on weight loss. The Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) randomized clinical trial included 609 adults aged 18 to 50 years without diabetes with a body mass index between 28 and 40. The trial enrollment was from January 29, 2013, through April 14, 2015; the date of final follow-up was May 16, 2016. Participants were randomized to the 12-month HLF or HLC diet. The study also tested whether 3 single-nucleotide polymorphism multilocus genotype responsiveness patterns or insulin secretion (INS-30; blood concentration of insulin 30 minutes after a glucose challenge) were associated with weight loss. Health educators delivered the behavior modification intervention to HLF (n = 305) and HLC (n = 304) participants via 22 diet-specific small group sessions administered over 12 months. The sessions focused on ways to achieve the lowest fat or carbohydrate intake that could be maintained long-term and emphasized diet quality. Primary outcome was 12-month weight change and determination of whether there were significant interactions among diet type and genotype pattern, diet and insulin secretion, and diet and weight loss. Among 609 participants randomized (mean age, 40 [SD, 7] years; 57% women; mean body mass index, 33 [SD, 3]; 244 [40%] had a low-fat genotype; 180 [30%] had a low-carbohydrate genotype; mean baseline INS-30, 93 μIU/mL), 481 (79%) completed the trial. In the HLF vs HLC diets, respectively, the mean 12-month macronutrient distributions were 48% vs 30% for carbohydrates

  4. Molecular beams

    International Nuclear Information System (INIS)

    Ramsey, N.F.

    1985-01-01

    This book is a timeless and rather complete theoretical and experimental treatment of electric and magnetic resonance molecular-beam experiments for studying the radio frequency spectra of atoms and molecules. The theory of interactions of the nucleus with atomic and molecular fields is extensively presented. Measurements of atomic and nuclear magnetic moments, electric multipole moments, and atomic fine and hyperfine structure are detailed. Useful but somewhat outdated chapters on gas kinetics, molecular beam design, and experimental techniques are also included

  5. Beam lifetime measurement and analysis in Indus-2 electron ...

    Indian Academy of Sciences (India)

    In this paper, the beam lifetime measurement and its theoretical analysis are presented using measured vacuum pressure and applied radio frequency (RF) cavity voltage in Indus-2 electron storage ring at 2 GeV beam energy. Experimental studies of the effect of RF cavity voltage and bunched beam filling pattern on beam ...

  6. End-of-Fill Diffusion and Halo Population Measurements with Physics Beams at 6.5 TeV

    CERN Document Server

    Valentino, Gianluca; Gorzawski, Arkadiusz; Redaelli, Stefano; Trad, Georges; Wagner, Joschka; Xu, Chen; CERN. Geneva. ATS Department

    2017-01-01

    Beam halo measurements at 6.5 TeV in the LHC were conducted with a full physics beam via collimator scrapings in end-of-fill MDs carried out in May and July 2016. From the time evolution of the beam losses in a collimator scan, it is possible to extract information on the halo diffusion and population. In the first MD, six scans were performed with two collimators in the vertical and horizontal planes in B1 and B2 respectively. The scans were done with squeezed colliding beams, with and without a gentle continuous transverse blow-up with the ADT (transverse damper) on a non-colliding bunch train. In the second MD, four scans were performed with the same collimators with squeezed colliding beams. The beam losses observed with the standard ionization chamber BLMs are compared to the diamond BLMs, and parametric fits of the diffusion model are applied to temporal loss patterns from colliding and non-colliding bunch trains. The results presented in this note also include the particle escape times and frequency an...

  7. Beam transport

    International Nuclear Information System (INIS)

    1988-01-01

    Considerable experience has now been gained with the various beam transport lines, and a number of minor changes have been made to improve the ease of operation. These include: replacement of certain little-used slits by profile monitors (harps or scanners); relocation of steering magnets, closer to diagnostic harps or profile scanners; installation of a scanner inside the isocentric neutron therapy system; and conversion of a 2-doublet quadrupole telescope (on the neutron therapy beamline) to a 2-triplet telescope. The beam-swinger project has been delayed by very late delivery of the magnet iron to the manufacturer, but is now progressing smoothly. The K=600 spectrometer magnets have now been delivered and are being assembled for field mapping. The x,y-table with its associated mapping equipment is complete, together with the driver software. One of the experimental areas has been dedicated to the production of collimated neutron beams and has been equipped with a bending magnet and beam dump, together with steel collimators fixed at 4 degrees intervals from 0 degrees to 16 degrees. Changes to the target cooling and shielding system for isotope production have led to a request for much smaller beam spot sizes on target, and preparations have been made for rearrangement of the isotope beamline to permit installation of quadrupole triplets on the three beamlines after the switching magnet. A practical system of quadrupoles for matching beam properties to the spectrometer has been designed. 6 figs

  8. Beam Dynamics Challenges for Future Circular Colliders

    CERN Multimedia

    Zimmermann, Frank

    2004-01-01

    The luminosity of hadron colliders rises with the beam intensity, until some limit is encountered, mostly due to head-on and long-range beam-beam interaction, due to electron cloud, or due to conventional impedance sources. Also beam losses caused by various mechanisms may affect the performance. The limitations can be alleviated, if not overcome, by a proper choice of beam parameters and by dedicated compensation schemes. Examples include alternating crossing at several interaction points, electromagnetic wires, super-bunches, electron lenses, clearing electrodes, and nonlinear collimation. I discuss such mitigating measures and related research efforts, with special emphasis on the LHC and its upgrade.

  9. Why care about linear hair growth rates (LHGR)? a study using in vivo imaging and computer assisted image analysis after manual processing (CAIAMP) in unaffected male controls and men with male pattern hair loss (MPHL).

    Science.gov (United States)

    Van Neste, Dominique

    2014-01-01

    The words "hair growth" frequently encompass many aspects other than just growth. Report on a validation method for precise non-invasive measurement of thickness together with linear hair growth rates of individual hair fibres. To verify the possible correlation between thickness and linear growth rate of scalp hair in male pattern hair loss as compared with healthy male controls. To document the process of validation of hair growth measurement from in vivo image capturing and manual processing, followed by computer assisted image analysis. We analysed 179 paired images obtained with the contrast-enhanced-phototrichogram method with exogen collection (CE-PTG-EC) in 13 healthy male controls and in 87 men with male pattern hair loss (MPHL). There was a global positive correlation between thickness and growth rate (ANOVA; pgrowth rate in MPHL as compared with equally thick hairs from controls. Finally, the growth rate recorded in the more severe patterns was significantly (ANOVA; P ≤ 0.001) reduced compared with equally thick hair from less severely affected MPHL or controls subjects. Reduced growth rate, together with thinning and shortening of the anagen phase duration in MPHL might contribute together to the global impression of decreased hair volume on the top of the head. Amongst other structural and functional parameters characterizing hair follicle regression, linear hair growth rate warrants further investigation, as it may be relevant in terms of self-perception of hair coverage, quantitative diagnosis and prognostic factor of the therapeutic response.

  10. LHC Report: Freshly squeezed beams!

    CERN Multimedia

    Mike Lamont for the LHC Team

    2011-01-01

    After careful validation of  new machine settings, the LHC was ready for higher luminosity operation. New luminosity records have been set, but the operations team continues to wrestle with machine availability issues.   The commissioning of the squeeze to a ß* of 1 m in ATLAS and CMS described in the last Bulletin took until Wednesday, 7 September to complete. In order to validate the new set-up, beam losses were provoked in a controlled way with low intensity beams. The distribution of beam loss around the machine in these tests is known as a loss map. The loss maps showed that the collimation system is catching the large majority of beam losses as it should, and that the machine was ready for us to ramp the number of bunches back up and go to physics production. The ramp-up of the number of bunches went smoothly with fills at 264, 480, and 912 bunches on the way back to the machine’s previous record of 1380 bunches (first fill on Friday, 9 Se...

  11. Male pattern baldness

    Science.gov (United States)

    ... baldness. Medicines that treat male pattern baldness include: Minoxidil (Rogaine), a solution that is applied directly to ... slows hair loss. It works slightly better than minoxidil. Hair loss returns when you stop using this ...

  12. Intensive Ion Beam In Storage Rings With Electron Cooling

    CERN Document Server

    Korotaev, Yu V; Kamerdjiev, V; Maier, R; Meshkov, I; Noda, K; Prasuhn, D; Sibuya, S; Sidorin, A; Stein, H J; Stockhorst, H; Syresin, E M; Uesugi, T

    2004-01-01

    Results of experimental studies of the electron cooling of a proton beam at COSY (Juelich, Germany) and an ion beam at HIMAC (Chiba, Japan) are presented. Intensity of the ion beam is limited by two general effects: particle loss directly after the injection and development of instability in a deep cooled ion beam. Methods of the instability suppression, which allow increasing the cooled beam intensity, are described.

  13. Collider and detector protection at beam accidents

    International Nuclear Information System (INIS)

    Rakhno, I.L.; Mokhov, N.V.; Drozhdin, A.I.

    2003-01-01

    Dealing with beam loss due to abort kicker prefire is considered for hadron colliders. The prefires occurred at Tevatron (Fermilab) during Run I and Run II are analyzed and a protection system implemented is described. The effect of accidental beam loss in the Large Hadron Collider (LHC) at CERN on machine and detector components is studied via realistic Monte Carlo calculations. The simulations show that beam loss at an unsynchronized beam abort would result in severe heating of conventional and superconducting magnets and possible damage to the collider detector elements. A proposed set of collimators would reduce energy deposition effects to acceptable levels. Special attention is paid to reducing peak temperature rise within the septum magnet and minimizing quench region length downstream of the LHC beam abort straight section

  14. Collider and Detector Protection at Beam Accidents

    International Nuclear Information System (INIS)

    Rakhno, I.L.; Mokhov, N.V.; Drozhdin, A.I.

    2003-01-01

    Dealing with beam loss due to abort kicker prefire is considered for hadron colliders. The prefires occurred at Tevatron (Fermilab) during Run I and Run II are analyzed and a protection system implemented is described. The effect of accidental beam loss in the Large Hadron Collider (LHC) at CERN on machine and detector components is studied via realistic Monte Carlo calculations. The simulations show that beam loss at an unsynchronized beam abort would result in severe heating of conventional and superconducting magnets and possible damage to the collider detector elements. A proposed set of collimators would reduce energy deposition effects to acceptable levels. Special attention is paid to reducing peak temperature rise within the septum magnet and minimizing quench region length downstream of the LHC beam abort straight section

  15. Quantum beams

    International Nuclear Information System (INIS)

    Uesaka, Mitsuru

    2003-01-01

    Present state and future prospect are described on quantum beams for medical use. Efforts for compactness of linac for advanced cancer therapy have brought about the production of machines like Accuray's CyberKnife and TOMOTHERAPY (Tomo Therapy Inc.) where the acceleration frequency of X-band (9-11 GHz) is used. For cervical vein angiography by the X-band linac, a compact hard X-ray source is developed which is based on the (reverse) Compton scattering through laser-electron collision. More intense beam and laser are necessary at present. A compact machine generating the particle beam of 10 MeV-1 GeV (laser-plasma accelerator) for cancer therapy is also developed using the recent compression technique (chirped-pulse amplification) to generate laser of >10 TW. Tokyo University is studying for the electron beam with energy of GeV order, for the laser-based synchrotron X-ray, and for imaging by the short pulse ion beam. Development of advanced compact accelerators is globally attempted. In Japan, a virtual laboratory by National Institute of Radiological Sciences (NIRS), a working group of universities and research facilities through the Ministry of Education, Culture, Sports, Science and Technology, started in 2001 for practical manufacturing of the above-mentioned machines for cancer therapy and for angiography. Virtual Factory (Inc.), a business venture, is to be stood in future. (N.I.)

  16. Optimization of Land Use Pattern Reduces Surface Runoff and Sediment Loss in a Hilly-Gully Watershed at the Loess Plateau, China

    Directory of Open Access Journals (Sweden)

    Han Yini

    2016-04-01

    Full Text Available Aim of study: The aim is to find a way increasing gain yield and lessen area of farmland, and then increasing vegetation cover, improving environment and alleviating soil erosion.Area of study: The Hilly-Gully region at the loess plateau of China.Material and methods: In this study, an adjusted and optimized land use pattern was developed in Luoyugou watershed in the Yellow River valley based on the gradient distribution of land use types, and its effect on water and sediment transport was simulated using the SWAT model and GIS, with remote sensing images, land use maps and hydrologic data.Main results: The results indicate: average simulated runoff and sediment for the period 1986-2000 under conditions of the three land use pattern (2011, 2008 and optimized land use reduced by 0.002-0.013 m3/s (2.7-17.6% and 0.66 million tons, respectively. The runoff and sediment data obtained were compared with observed data from 2008, which showed that runoff and sediment production would be reduced by 467625 m3 and 22754 tons, respectively.Research highlights: The adjustment of the land use pattern in comprehensive consideration of vegetation and geography have a positive effect on water and sediment transport which will be important for decision making and water resources management, and provides a reference for future environmental management and ecological construction in the loess plateau Hilly-Gully region. 

  17. Optimization of Land Use Pattern Reduces Surface Runoff and Sediment Loss in a Hilly-Gully Watershed at the Loess Plateau, China

    Energy Technology Data Exchange (ETDEWEB)

    Yini, H.; Jianzhi, N.; Zhongbao, X.; Wei, Z.; Tielin, Z.; Xilin, W.; Yousong, Z.

    2016-07-01

    Aim of study: The aim is to find a way increasing gain yield and lessen area of farmland, and then increasing vegetation cover, improving environment and alleviating soil erosion. Area of study: The Hilly-Gully region at the loess plateau of China. Material and methods: In this study, an adjusted and optimized land use pattern was developed in Luoyugou watershed in the Yellow River valley based on the gradient distribution of land use types, and its effect on water and sediment transport was simulated using the SWAT model and GIS, with remote sensing images, land use maps and hydrologic data. Main results: The results indicate: average simulated runoff and sediment for the period 1986-2000 under conditions of the three land use pattern (2011, 2008 and optimized land use) reduced by 0.002-0.013 m3/s (2.7-17.6%) and 0.66 million tons, respectively. The runoff and sediment data obtained were compared with observed data from 2008, which showed that runoff and sediment production would be reduced by 467625 m3 and 22754 tons, respectively. Research highlights: The adjustment of the land use pattern in comprehensive consideration of vegetation and geography have a positive effect on water and sediment transport which will be important for decision making and water resources management, and provides a reference for future environmental management and ecological construction in the loess plateau Hilly-Gully region. (Author)

  18. Epigenetic Changes in the Methylation Patterns of KCNQ1 and WT1 after a Weight Loss Intervention Program in Obese Stroke Patients.

    Science.gov (United States)

    Abete, Itziar; Gómez-Úriz, Ana M; Mansego, María L; De Arce, Ana; Goyenechea, Estíbaliz; Blázquez, Vanessa; Martínez-Zabaleta, Maria T; González-Muniesa, Pedro; López De Munain, Adolfo; Martínez, J Alfredo; Campión, Javier; Milagro, Fermin I

    2015-01-01

    Ischemic stroke patients often show high concentrations of circulating inflammatory markers that are associated with increased risk of recurrence. Epigenetic mechanisms could be involved in obesity, inflammation and stroke. The objective of this research was to investigate, in obese patients suffering a previous stroke, the effects of a nutritional program on anthropometric and biochemical variables, and on the methylation patterns of two stroke-related genes (KCNQ1: potassium channel, voltage gated KQT-like subfamily Q, member 1; and WT1: Wilms tumor 1). Twenty-two ischemic stroke patients were compared with a control group composed of eighteen obese subjects with similar age and body mass index ranges. Both groups followed a 20-week nutritional program based on an energy-restricted balanced diet with high adherence to the Mediterranean dietary pattern. The intervention significantly improved anthropometric and metabolic variables, such as the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and C-reactive protein concentration, in ischemic stroke patients, and was accompanied by changes in the methylation patterns of both stroke-related genes, which correlated with anthropometric and biochemical variables.

  19. Specialized beam diagnostic measurements for an ADTT accelerator funnel

    International Nuclear Information System (INIS)

    Gilpatrick, John Douglas

    1995-01-01

    Los Alamos National Laboratory has proposed several CW-proton-beam facilities for accelerator-driven transmutation technologies (ADTT) with beam-current densities greater than 5 mA/mm 2 . The primary beam-diagnostics-instrumentation requirement for these facilities is to provide sufficient beam information to understand and minimize beam-loss. To accomplish this task, the beam diagnostics instrumentation must measure beam parameters such as the projected centroids and profiles, total integrated current, and particle loss. Because of the high specific energy loss in materials at beam energies less than 20 MeV, interceptive measurements such as wire scanners or fluors cannot be used to determine beam profiles or centroids. Therefore, noninterceptive techniques must be used for on-line diagnosis of high-intensity CW beam at low energies. The beam funnel area of these proposed accelerator facilities provide a particular interesting beam measurement challenge. In this area of the accelerator, beam measurements must also sense how well the two funnel input-beams are matched to each other in phase space. This paper will discuss some of the measurement requirements for these proposed accelerator facilities and the various noninterceptive techniques to measure dual-beam funnel operation

  20. Specialized beam diagnostic measurements for an ADTT accelerator funnel

    International Nuclear Information System (INIS)

    Gilpatrick, J.D.

    1995-01-01

    Los Alamos National Laboratory has proposed several CW-proton-beam facilities for accelerator-driven transmutation technologies (ADTT) with beam-current densities greater than 5 mA/mm 2 . The primary beam-diagnostics-instrumentation requirement for these facilities is to provide sufficient beam information to understand and minimize beam-loss. To accomplish this task, the beam diagnostics instrumentation must measure beam parameters such as the projected centroids and profiles, total integrated current, and particle loss. Because of the high specific energy loss in materials at beam energies less than 20 MeV, interceptive measurements such as wire scanners or fluors cannot be used to determine beam profiles or centroids. Therefore, noninterceptive techniques must be used for on-line diagnosis of high-intensity CW beam at low energies. The beam funnel area of these proposed accelerator facilities provide a particular interesting beam measurement challenge. In this area of the accelerator, beam measurements must also sense how well the two funnel-input-beams are matched to each other in phase space. This paper will discuss some of the measurement requirements for these proposed accelerator facilities and the various noninterceptive techniques to measure dual-beam funnel operation