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Sample records for beam breast x-ray

  1. Hard X-ray Microscopic Imaging Of Human Breast Tissues

    Science.gov (United States)

    Park, Sung H.; Kim, Hong T.; Kim, Jong K.; Jheon, Sang H.; Youn, Hwa S.

    2007-01-01

    X-ray microscopy with synchrotron radiation will be a useful tool for innovation of x-ray imaging in clinical and laboratory settings. It helps us observe detailed internal structure of material samples non-invasively in air. And, it also has the potential to solve some tough problems of conventional breast imaging if it could evaluate various conditions of breast tissue effectively. A new hard x-ray microscope with a spatial resolution better than 100 nm was installed at Pohang Light Source, a third generation synchrotron radiation facility in Pohang, Korea. The x-ray energy was set at 6.95 keV, and the x-ray beam was monochromatized by W/B4C monochromator. Condenser and objective zone plates were used as x-ray lenses. Zernike phase plate next to condenser zone plate was introduced for improved contrast imaging. The image of a sample was magnified 30 times by objective zone plate and 20 times by microscope objective, respectively. After additional 10 times digital magnification, the total magnifying power was up to 6000 times in the end. Phase contrast synchrotron images of 10-μm-thick female breast tissue of the normal, fibroadenoma, fibrocystic change and carcinoma cases were obtained. By phase contrast imaging, hard x-rays enable us to observe many structures of breast tissue without sample preparations such as staining or fixation.

  2. Experimental investigation for determination of optimal X-ray beam tube voltages in a newly developed digital breast tomosynthesis system

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hye-Suk, E-mail: radiosugar@yonsei.ac.kr [Department of Radiological Science and Research Institute of Health Science, Yonsei University, Wonju, Gangwon 220-710 (Korea, Republic of); Kim, Ye-Seul, E-mail: radiohesugar@gmail.com [Department of Radiological Science and Research Institute of Health Science, Yonsei University, Wonju, Gangwon 220-710 (Korea, Republic of); Choi, Young-Wook, E-mail: ywchoi@keri.re.kr [Korea Electrotechnology Research Institute (KERI), Ansan, Geongki 426-170 (Korea, Republic of); Choi, JaeGu, E-mail: jgchoi88@paran.com [Korea Electrotechnology Research Institute (KERI), Ansan, Geongki 426-170 (Korea, Republic of); Rhee, Yong-Chun, E-mail: ycrhee@yonsei.ac.kr [Department of Radiological Science and Research Institute of Health Science, Yonsei University, Wonju, Gangwon 220-710 (Korea, Republic of); Kim, Hee-Joung, E-mail: hjk1@yonsei.ac.kr [Department of Radiological Science and Research Institute of Health Science, Yonsei University, Wonju, Gangwon 220-710 (Korea, Republic of)

    2014-11-01

    Our purpose was to investigate optimal tube voltages (kVp) for a newly developed digital breast tomosynthesis (DBT) process and to determine tube current–exposure time products (mA s) for the average glandular dose (AGD), which is similar to that of the two views in conventional mammography (CM). In addition, the optimal acquisition parameters for this system were compared with those of CM. The analysis was based on the contrast-to-noise ratio (CNR) from the simulated micro-calcifications on homogeneous phantoms, and the figure of merit (FOM) was retrieved from the CNR and AGD at X-ray tube voltages ranging from 24 to 40 kVp at intervals of 2 kV. The optimal kVp increased more than 2 kV with increasing glandularity for thicker (≥50 mm) breast phantoms. The optimal kVp for DBT was found to be 4–7 kV higher than that calculated for CM with breast phantoms thicker than 50 mm. This is likely due to the greater effect of noise and dose reduction by kVp increment when using the lower dose per projection in DBT. It is important to determine optimum acquisition conditions for a maximally effective DBT system. The results of our study provide useful information to further improve DBT for high quality imaging.

  3. Towards standardization of x-ray beam filters in digital mammography and digital breast tomosynthesis: Monte Carlo simulations and analytical modelling

    Science.gov (United States)

    Shrestha, Suman; Vedantham, Srinivasan; Karellas, Andrew

    2017-03-01

    In digital breast tomosynthesis and digital mammography, the x-ray beam filter material and thickness vary between systems. Replacing K-edge filters with Al was investigated with the intent to reduce exposure duration and to simplify system design. Tungsten target x-ray spectra were simulated with K-edge filters (50 µm Rh; 50 µm Ag) and Al filters of varying thickness. Monte Carlo simulations were conducted to quantify the x-ray scatter from various filters alone, scatter-to-primary ratio (SPR) with compressed breasts, and to determine the radiation dose to the breast. These data were used to analytically compute the signal-difference-to-noise ratio (SDNR) at unit (1 mGy) mean glandular dose (MGD) for W/Rh and W/Ag spectra. At SDNR matched between K-edge and Al filtered spectra, the reductions in exposure duration and MGD were quantified for three strategies: (i) fixed Al thickness and matched tube potential in kilovolts (kV); (ii) fixed Al thickness and varying the kV to match the half-value layer (HVL) between Al and K-edge filtered spectra; and, (iii) matched kV and varying the Al thickness to match the HVL between Al and K-edge filtered spectra. Monte Carlo simulations indicate that the SPR with and without the breast were not different between Al and K-edge filters. Modelling for fixed Al thickness (700 µm) and kV matched to K-edge filtered spectra, identical SDNR was achieved with 37–57% reduction in exposure duration and with 2–20% reduction in MGD, depending on breast thickness. Modelling for fixed Al thickness (700 µm) and HVL matched by increasing the kV over (0,4) range, identical SDNR was achieved with 62–65% decrease in exposure duration and with 2–24% reduction in MGD, depending on breast thickness. For kV and HVL matched to K-edge filtered spectra by varying Al filter thickness over (700, 880) µm range, identical SDNR was achieved with 23–56% reduction in exposure duration and 2–20% reduction in MGD, depending on breast thickness

  4. Breast density mapping based upon system calibration, x-ray techniques, and FFDM images

    Science.gov (United States)

    Chen, Biao; Smith, Andrew P.; Jing, Zhenxue; Wu, Tao

    2007-03-01

    Clinical studies have correlated a high breast density to a women's risk of breast cancer. A breast density measurement that can quantitatively depict the volume distribution and percentage of dense tissues in breasts would be very useful for risk factor assessment of breast cancer, and might be more predictive of risks than the common but subjective and coarse 4-point BIRADS scale. This paper proposes to use a neural-network mapping to compute the breast density information based upon system calibration data, x-ray techniques, and Full Field Digital Mammography (FFDM) images. The mapping consists of four modules, namely, system calibration, generator of beam quality, generator of normalized absorption, and a multi-layer feed-forward neural network. As the core of breast density mapping, the network accepts x-ray target/filter combination, normalized x-ray absorption, pixel-wise breast thickness map, and x-ray beam quality during image acquisition as input elements, and exports a pixel-wise breast density distribution and a single breast density percentage for the imaged breast. Training and testing data sets for the design and verification of the network were formulated from calibrated x-ray beam quality, imaging data with a step wedge phantom under a variety x-ray imaging techniques, and nominal breast densities of tissue equivalent materials. The network was trained using a Levenberg-Marquardt algorithm based back-propagation learning method. Various thickness and glandular density phantom studies were performed with clinical x-ray techniques. Preliminary results showed that the neural network mapping is promising in accurately computing glandular density distribution and breast density percentage.

  5. Quantitative cone beam X-ray luminescence tomography/X-ray computed tomography imaging

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Dongmei; Zhu, Shouping, E-mail: zhusp2009@gmail.com; Chen, Xueli; Chao, Tiantian; Cao, Xu; Zhao, Fengjun; Huang, Liyu; Liang, Jimin [Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education and School of Life Science and Technology, Xidian University, Xi' an, Shaanxi 710071 (China)

    2014-11-10

    X-ray luminescence tomography (XLT) is an imaging technology based on X-ray-excitable materials. The main purpose of this paper is to obtain quantitative luminescence concentration using the structural information of the X-ray computed tomography (XCT) in the hybrid cone beam XLT/XCT system. A multi-wavelength luminescence cone beam XLT method with the structural a priori information is presented to relieve the severe ill-posedness problem in the cone beam XLT. The nanophosphors and phantom experiments were undertaken to access the linear relationship of the system response. Then, an in vivo mouse experiment was conducted. The in vivo experimental results show that the recovered concentration error as low as 6.67% with the location error of 0.85 mm can be achieved. The results demonstrate that the proposed method can accurately recover the nanophosphor inclusion and realize the quantitative imaging.

  6. Calibration of Cone Beam Rotational X-Ray Image Sequence

    Institute of Scientific and Technical Information of China (English)

    YUHengyong; MOUXuanqin; CAIYuanlong

    2004-01-01

    The real X-ray projection does not abide by Lambert-Beer Law, since the X-ray is polychromatic and the imaging chains are nonlinear. Based on the generating process of X-ray images, an equivalent nonlinear transform model is firstly proposed which considers all the nonlinear factors as one nonlinear transform. Then the 3D (three-dimensional) X-ray projection of cone beam is defined. The constraints of Radon transform, named H-L (Helgasson-ludwig) consistency conditions, are expanded to fan-beam. After that an algorithm is developed to calibrate Rotational X-ray image sequence (RXIS). The algorithm uses a set of exponential functions to approximate the nonlinear inverse transform. According to expanded H-L consistency conditions, finally a kind of nonlinear measure for RXIS is defined. Experimental results show that the proposed algorithm can decrease the nonlinear measure to below 0.01.

  7. Highly porous nanoberyllium for X-ray beam speckle suppression

    Energy Technology Data Exchange (ETDEWEB)

    Goikhman, Alexander, E-mail: agoikhman@ymail.com; Lyatun, Ivan; Ershov, Petr [Immanuel Kant Baltic Federal University, Nevskogo str. 14, Kaliningrad 236041 (Russian Federation); Snigireva, Irina [European Synchrotron Radiation Facility, BP 220, 38043 Grenoble (France); Wojda, Pawel [Immanuel Kant Baltic Federal University, Nevskogo str. 14, Kaliningrad 236041 (Russian Federation); Gdańsk University of Technology, 11/12 G. Narutowicza, Gdańsk 80-233 (Poland); Gorlevsky, Vladimir; Semenov, Alexander; Sheverdyaev, Maksim; Koletskiy, Viktor [A. A. Bochvar High-Technology Scientific Research Institute for Inorganic Materials, Rogova str. 5a, Moscow 123098 (Russian Federation); Snigirev, Anatoly [Immanuel Kant Baltic Federal University, Nevskogo str. 14, Kaliningrad 236041 (Russian Federation); European Synchrotron Radiation Facility, BP 220, 38043 Grenoble (France)

    2015-04-09

    A speckle suppression device containing highly porous nanoberyllium is proposed for manipulating the spatial coherence length and removing undesirable speckle structure during imaging experiments. This paper reports a special device called a ‘speckle suppressor’, which contains a highly porous nanoberyllium plate squeezed between two beryllium windows. The insertion of the speckle suppressor in an X-ray beam allows manipulation of the spatial coherence length, thus changing the effective source size and removing the undesirable speckle structure in X-ray imaging experiments almost without beam attenuation. The absorption of the nanoberyllium plate is below 1% for 1 mm thickness at 12 keV. The speckle suppressor was tested on the ID06 ESRF beamline with X-rays in the energy range from 9 to 15 keV. It was applied for the transformation of the phase–amplitude contrast to the pure amplitude contrast in full-field microscopy.

  8. Application of small-angle X-ray scattering for differentiation among breast tumors

    Directory of Open Access Journals (Sweden)

    Changizi V

    2008-01-01

    Full Text Available Small-angle X-ray scattering (SAXS is an X-ray diffraction-based technique where a narrow collimated beam of X-rays is focused onto a sample and the scattered X-rays recorded by a detector. The pattern of the scattered X-rays carries information on the molecular structure of the material. As breast cancer is the most widespread cancer in women and differentiation among its tumors is important, this project compared the results of coherent X-ray scattering measurements obtained from benign and malignant breast tissues. The energy-dispersive method with a setup including X-ray tube, primary collimator, sample holder, secondary collimator and high-purity germanium (HpGe detector was used. One hundred thirty-one breast-tissue samples, including normal, fibrocystic changes and carcinoma, were studied at the 6° scattering angle. Diffraction profiles (corrected scattered intensity versus momentum transfer of normal, fibrocystic changes and carcinoma were obtained. These profiles showed a few peak positions for adipose (1.15 ± 0.06 nm -1 , mixed normal (1.15 ± 0.06 nm -1 and 1.4 ± 0.04 nm -1 , fibrocystic changes (1.46 ± 0.05 nm -1 and 1.74 ± 0.04 nm -1 and carcinoma (1.55 ± 0.04 nm -1 , 1.73 ± 0.06 nm -1 , 1.85 ± 0.05 nm -1 . We were able to differentiate between normal, fibrocystic changes (benign and carcinoma (malignant breast tissues by SAXS. However, we were unable to differentiate between different types of carcinoma.

  9. X-ray cone beam CT system calibration

    Science.gov (United States)

    Sire, Pascal; Rizo, Philippe; Martin, M.

    1993-12-01

    Recently x-ray cone beam computed tomography (CT) has become of interest for nondestructive testing (NDT) of advanced materials. Such a technique takes advantage of the cone beam geometry, to reduce the acquisition time and increase the resolution. Performances of CT systems rely mainly on geometric precision and measurement quality. Inaccurate geometry or incorrect data produce artifacts and blurring which limit the spatial resolution. A precise geometric calibration procedure is required and some corrections must be applied to the raw attenuation data in order to obtain accurate measurements. An x-ray cone beam CT system has been developed at the LETI. This machine was designed to control small parts limited to a few centimeters, with a high spatial resolution close to 30 microns. This paper introduces the machine setup and describes the calibration computing resources involved in the system. Then, we discuss the performances on experimental data.

  10. Motorized Beam Alignment of a Commercial X-ray Diffractometer

    Science.gov (United States)

    Van Zandt, Noah R.; Myers, James F.; Rogers, Richard B

    2013-01-01

    X-ray diffraction (XRD) is a powerful analysis method that allows researchers to noninvasively probe the crystalline structure of a material. This includes the ability to determine the crystalline phases present, quantify surface residual stresses, and measure the distribution of crystallographic orientations. The Structures and Materials Division at the NASA Glenn Research Center (GRC) heavily uses the on-site XRD lab to characterize advanced metal alloys, ceramics, and polymers. One of the x-ray diffractometers in the XRD lab (Bruker D8 Discover) uses three different x-ray tubes (Cu, Cr, and Mn) for optimal performance over numerous material types and various experimental techniques. This requires that the tubes be switched out and aligned between experiments. This alignment maximizes the x-ray tube s output through an iterative process involving four set screws. However, the output of the x-ray tube cannot be monitored during the adjustment process due to standard radiation safety engineering controls that prevent exposure to the x-ray beam when the diffractometer doors are open. Therefore, the adjustment process is a very tedious series of blind adjustments, each followed by measurement of the output beam using a PIN diode after the enclosure doors are shut. This process can take up to 4 hr to perform. This technical memorandum documents an in-house project to motorize this alignment process. Unlike a human, motors are not harmed by x-ray radiation of the energy range used in this instrument. Therefore, using motors to adjust the set screws will allow the researcher to monitor the x-ray tube s output while making interactive adjustments from outside the diffractometer. The motorized alignment system consists of four motors, a motor controller, and a hand-held user interface module. Our goal was to reduce the alignment time to less than 30 min. The time available was the 10-week span of the Lewis' Educational and Research Collaborative Internship Project (LERCIP

  11. Superficial and orthovoltage x-ray beam dosimetry.

    Science.gov (United States)

    Podgorsak, E B; Gosselin, M; Evans, M D

    1998-07-01

    Output of superficial and orthovoltage x-ray units may be measured with cylindrical or end-window parallel-plate ionization chambers. The air-kerma calibration factors for these chambers are usually determined free in air, and the x-ray machine output is stated as the air-kerma rate free in air, which, when multiplied with the appropriate backscatter factor, gives the air-kerma rate on the surface of a phantom or patient. For end-window chambers, especially when they are used for measurements of small fields or low x-ray energies, the air-kerma calibration factors may also be determined with the chamber embedded in a tissue-equivalent phantom. This results in field size dependent air-kerma in-air calibration factors but obviates the requirement for knowledge of back-scatter factors when determining the air-kerma rate on the surface of a phantom. Since there still is considerable uncertainty in tabulated backscatter factors as a function of field size and x-ray beam energy, the output measurement technique which determines the air-kerma rate on phantom surface with a phantom-embedded end-window ionization chamber offers a clear advantage over the in-air calibration method.

  12. Dosimetry in x-ray-based breast imaging

    Science.gov (United States)

    Dance, David R.; Sechopoulos, Ioannis

    2016-10-01

    The estimation of the mean glandular dose to the breast (MGD) for x-ray based imaging modalities forms an essential part of quality control and is needed for risk estimation and for system design and optimisation. This review considers the development of methods for estimating the MGD for mammography, digital breast tomosynthesis (DBT) and dedicated breast CT (DBCT). Almost all of the methodology used employs Monte Carlo calculated conversion factors to relate the measurable quantity, generally the incident air kerma, to the MGD. After a review of the size and composition of the female breast, the various mathematical models used are discussed, with particular emphasis on models for mammography. These range from simple geometrical shapes, to the more recent complex models based on patient DBCT examinations. The possibility of patient-specific dose estimates is considered as well as special diagnostic views and the effect of breast implants. Calculations using the complex models show that the MGD for mammography is overestimated by about 30% when the simple models are used. The design and uses of breast-simulating test phantoms for measuring incident air kerma are outlined and comparisons made between patient and phantom-based dose estimates. The most widely used national and international dosimetry protocols for mammography are based on different simple geometrical models of the breast, and harmonisation of these protocols using more complex breast models is desirable.

  13. Wavefront aberrations of x-ray dynamical diffraction beams.

    Science.gov (United States)

    Liao, Keliang; Hong, Youli; Sheng, Weifan

    2014-10-01

    The effects of dynamical diffraction in x-ray diffractive optics with large numerical aperture render the wavefront aberrations difficult to describe using the aberration polynomials, yet knowledge of them plays an important role in a vast variety of scientific problems ranging from optical testing to adaptive optics. Although the diffraction theory of optical aberrations was established decades ago, its application in the area of x-ray dynamical diffraction theory (DDT) is still lacking. Here, we conduct a theoretical study on the aberration properties of x-ray dynamical diffraction beams. By treating the modulus of the complex envelope as the amplitude weight function in the orthogonalization procedure, we generalize the nonrecursive matrix method for the determination of orthonormal aberration polynomials, wherein Zernike DDT and Legendre DDT polynomials are proposed. As an example, we investigate the aberration evolution inside a tilted multilayer Laue lens. The corresponding Legendre DDT polynomials are obtained numerically, which represent balanced aberrations yielding minimum variance of the classical aberrations of an anamorphic optical system. The balancing of classical aberrations and their standard deviations are discussed. We also present the Strehl ratio of the primary and secondary balanced aberrations.

  14. X-ray emission as a diagnostic from pseudospark-sourced electron beams

    Energy Technology Data Exchange (ETDEWEB)

    Bowes, D., E-mail: david.bowes@strath.ac.uk [Department of Physics, SUPA, University of Strathclyde, Glasgow G4 0NG (United Kingdom); Yin, H.; He, W.; Zhang, L.; Cross, A.W.; Ronald, K.; Phelps, A.D.R. [Department of Physics, SUPA, University of Strathclyde, Glasgow G4 0NG (United Kingdom); Chen, D.; Zhang, P. [Computed Tomography Lab, School of Mathematical Sciences, Capital Normal University, Beijing 100048 (China); Chen, X.; Li, D. [Department of Electronic Engineering, Queen Mary University of London, London E1 4NS (United Kingdom)

    2014-09-15

    X-ray emission has been achieved using an electron beam generated by a pseudospark low-pressure discharge and utilised as a diagnostic for beam detection. A 300 A, 34 kV PS-sourced electron beam pulse of 3 mm diameter impacting on a 0.1 mm-thick molybdenum target generated X-rays which were detected via the use of a small, portable X-ray detector. Clear X-ray images of a micro-sized object were captured using an X-ray photodetector. This demonstrates the inducement of proton induced X-ray emission (PIXE) not only as an indicator of beam presence but also as a future X-ray source for small-spot X-ray imaging of materials.

  15. X-Ray Methods to Estimate Breast Density Content in Breast Tissue

    Science.gov (United States)

    Maraghechi, Borna

    This work focuses on analyzing x-ray methods to estimate the fat and fibroglandular contents in breast biopsies and in breasts. The knowledge of fat in the biopsies could aid in their wide-angle x-ray scatter analyses. A higher mammographic density (fibrous content) in breasts is an indicator of higher cancer risk. Simulations for 5 mm thick breast biopsies composed of fibrous, cancer, and fat and for 4.2 cm thick breast fat/fibrous phantoms were done. Data from experimental studies using plastic biopsies were analyzed. The 5 mm diameter 5 mm thick plastic samples consisted of layers of polycarbonate (lexan), polymethyl methacrylate (PMMA-lucite) and polyethylene (polyet). In terms of the total linear attenuation coefficients, lexan ≡ fibrous, lucite ≡ cancer and polyet ≡ fat. The detectors were of two types, photon counting (CdTe) and energy integrating (CCD). For biopsies, three photon counting methods were performed to estimate the fat (polyet) using simulation and experimental data, respectively. The two basis function method that assumed the biopsies were composed of two materials, fat and a 50:50 mixture of fibrous (lexan) and cancer (lucite) appears to be the most promising method. Discrepancies were observed between the results obtained via simulation and experiment. Potential causes are the spectrum and the attenuation coefficient values used for simulations. An energy integrating method was compared to the two basis function method using experimental and simulation data. A slight advantage was observed for photon counting whereas both detectors gave similar results for the 4.2 cm thick breast phantom simulations. The percentage of fibrous within a 9 cm diameter circular phantom of fibrous/fat tissue was estimated via a fan beam geometry simulation. Both methods yielded good results. Computed tomography (CT) images of the circular phantom were obtained using both detector types. The radon transforms were estimated via four energy integrating

  16. Measurement of X-ray beam emittance using crystal optics at an X-ray undulator beamline

    CERN Document Server

    Kohmura, Y; Awaji, M; Tanaka, T; Hara, T; Goto, S; Ishikawa, T

    2000-01-01

    We present a method of using crystal optics to measure the emittance of the X-ray source. Two perfect crystals set in (++) configuration work as a high-resolution collimator. The phase-space diagram (i.e. beam cross-section and angular distribution) could be determined without any assumptions on the light source. When the measurement is done at short wavelength radiation from undulator, the electron beam emittance is larger than the diffraction limit of the X-rays. Therefore, the electron beam emittance could be estimated. The measurement was done with the hard X-rays of 18.5 and 55 keV from an undulator beamline, BL 47XU, of SPring-8. The horizontal emittance of the X-ray beam was estimated to be about 7.6 nmrad, close to the designed electron beam emittance of the storage ring (7 nmrad). Some portions of the instrumental functions, such as the scattering by filters and windows along the beamline and the slight bent of the crystal planes of the monochromator, could not be precisely evaluated, but an upper li...

  17. Electron Beam Pattern Writer For X-Ray Masks

    Science.gov (United States)

    Viswanathan, R.; Wilson, A. D.; Lafuente, J.; Voelker, H.; Kern, A.

    1984-03-01

    This paper discusses the capabilities of a vector scan electron-beam system as an X-ray mask writer for pattern geometries at and below one-half micron. The noise level in the deflection system has been reduced to an RMS value of 150 A over a 0.5 mm deflection field, thus making our exposure system usable in the one-quarter micron regime. Pattern geometries below 2000 A have been fabricated on a thin membrane. Drift compensation techniques, implemented in software, have reduced placement errors over the entire mask to less than 700 A. Accomplishments in the areas of noise reduction, bandwidth error compensation, system resolution, and improvements in pattern placement accuracy are discussed.

  18. X-ray-ultraviolet beam splitters for the Michelson interferometer.

    Science.gov (United States)

    Delmotte, Franck; Ravet, Marie-Françoise; Bridou, Françoise; Varnière, Françoise; Zeitoun, Philippe; Hubert, Sébastien; Vanbostal, Laurent; Soullie, Gérard

    2002-10-01

    With the aim of realizing a Michelson interferometer working at 13.9 nm, we have developed a symmetrical beam splitter with multilayers deposited on the front and back sides of a silicon nitride membrane. On the basis of the experimental optical properties of the membrane, simulations have been performed to define the multilayer structure that provides the highest reflectivity-transmission product. Optimized Mo-Si multilayers have been successfully deposited on both sides of t he membrane by use of the ion-beam sputtering technique, with a thickness-period reproducibility of 0.1 nm. Measurements by means of synchrotron radiation at 13.9 nm and at an angle of 45 degrees provide a reflectivity of 14.2% and a transmission of 15.2% for a 60% s-polarized light, close to the simulated values. Such a beam splitter has been used for x-ray laser Michelson interferometry at 13.9 nm. The first interferogram is discussed.

  19. On the response of electronic personal dosimeters in constant potential and pulsed x- ray beams

    Science.gov (United States)

    Guimarães, M. C.; Silva, C. R. E.; Oliveira, P. M. C.; da Silva, T. A.

    2016-07-01

    Electronic personal dosimeters (EPDs) based on solid state detectors have widely been used but some deficiencies in their response in pulsed radiation beams have been reported. Nowadays, there is not an international standard for pulsed x-ray beams for calibration or type testing of dosimeters. Irradiation conditions for testing the response of EPDs in both the constant potential and pulsed x-ray beams were established in CDTN. Three different types of EPDs were tested in different conditions in similar ISO and IEC x-ray qualities. Results stressed the need of performing additional checks before using EPDs in constant potential or pulsed x-rays.

  20. On the response of electronic personal dosimeters in constant potential and pulsed X-ray beams

    Energy Technology Data Exchange (ETDEWEB)

    Guimaraes, Margarete C.; Silva, Teogenes; Silva, Claudete R.E., E-mail: margaretecristinag@gmail.com [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Oliveira, Paulo Marcio C. de [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Anatomia e Imagem

    2015-07-01

    Electronic personal dosimeters (EPDs) based on solid state detectors have widely been used but some deficiencies in their response in pulsed radiation beams have been reported. Nowadays, there is not an international standard for pulsed X-ray beams for calibration or type testing of dosimeters. Irradiation conditions for testing the response of EPDs in both the constant potential and pulsed X-ray beams were established in CDTN. Three different types of EPDs were tested in different conditions in similar ISO and IEC X-ray qualities. Results stressed the need of performing additional checks before using EPDs in constant potential or pulsed X-rays. (author)

  1. X-Ray Phase Imaging for Breast Cancer Detection

    Science.gov (United States)

    2011-09-01

    A. Yan, X. Wu, and H. Liu, Robustness of phase retrieval methods in x-ray phase contrast imaging: A comparison, Medical Physics 38: 5073-5080...2004. A new theory of phase-contrast x-ray imaging based on Wigner distributions. Medical Physics 31, 2378-2384. Wu X, Liu, H, Yan, A. 2005...Yan A., Wu X., Liu H. 2011. Robustness of phase retrieval methods in x-ray phase contrast imaging: A comparison, Medical Physics 38: 5073-5080

  2. X-ray scatter correction method for dedicated breast computed tomography: improvements and initial patient testing

    Science.gov (United States)

    Ramamurthy, Senthil; D'Orsi, Carl J.; Sechopoulos, Ioannis

    2016-02-01

    A previously proposed x-ray scatter correction method for dedicated breast computed tomography was further developed and implemented so as to allow for initial patient testing. The method involves the acquisition of a complete second set of breast CT projections covering 360° with a perforated tungsten plate in the path of the x-ray beam. To make patient testing feasible, a wirelessly controlled electronic positioner for the tungsten plate was designed and added to a breast CT system. Other improvements to the algorithm were implemented, including automated exclusion of non-valid primary estimate points and the use of a different approximation method to estimate the full scatter signal. To evaluate the effectiveness of the algorithm, evaluation of the resulting image quality was performed with a breast phantom and with nine patient images. The improvements in the algorithm resulted in the avoidance of introduction of artifacts, especially at the object borders, which was an issue in the previous implementation in some cases. Both contrast, in terms of signal difference and signal difference-to-noise ratio were improved with the proposed method, as opposed to with the correction algorithm incorporated in the system, which does not recover contrast. Patient image evaluation also showed enhanced contrast, better cupping correction, and more consistent voxel values for the different tissues. The algorithm also reduces artifacts present in reconstructions of non-regularly shaped breasts. With the implemented hardware and software improvements, the proposed method can be reliably used during patient breast CT imaging, resulting in improvement of image quality, no introduction of artifacts, and in some cases reduction of artifacts already present. The impact of the algorithm on actual clinical performance for detection, diagnosis and other clinical tasks in breast imaging remains to be evaluated.

  3. RF Phase Stability and Electron Beam Characterization for the PLEIADES Thomson X-Ray Source

    Energy Technology Data Exchange (ETDEWEB)

    Brown, W J; Hartemann, F V; Tremaine, A M; Springer, P T; Le Sage, G P; Barty, C P J; Rosenzweig, J B; Crane, J K; Cross, R R; Fittinghoff, D N; Gibson, D J; Slaughter, D R; Anderson, S

    2002-10-16

    We report on the performance of an S-band RF photocathode electron gun and accelerator for operation with the PLEIADES Thomson x-ray source at LLNL. To produce picosecond, high brightness x-ray pulses, picosecond timing, terahertz bandwidth diagnostics, and RF phase control are required. Planned optical, RF, x-ray and electron beam measurements to characterize the dependence of electron beam parameters and synchronization on RF phase stability are presented.

  4. X-ray topography using the forward transmitted beam under multiple-beam diffraction conditions.

    Science.gov (United States)

    Tsusaka, Y; Takeda, S; Takano, H; Yokoyama, K; Kagoshima, Y; Matsui, J

    2016-02-01

    X-ray topographs are taken for a sapphire wafer with the [0001] surface normal, as an example, by forward transmitted synchrotron x-ray beams combined with two-dimensional electronic arrays in the x-ray detector having a spatial resolution of 1 μm. They exhibit no shape deformation and no position shift of the dislocation lines on the topographs. Since the topography is performed under multiple-beam diffraction conditions, the topographic images of a single diffraction (two-wave approximation condition) or plural diffractions (six-wave approximation condition) can be recorded without large specimen position changes. As usual Lang topographs, it is possible to determine the Burgers vector of each dislocation line. Because of high parallelism of the incoming x-rays and linear sensitivity of the electronic arrays to the incident x-rays, the present technique can be used to visualize individual dislocations in single crystals of the dislocation density as high as 1 × 10(5) cm(-2).

  5. Structured x-ray beams from twisted electrons by inverse Compton scattering of laser light

    CERN Document Server

    Seipt, D; Fritzsche, S

    2014-01-01

    The inverse Compton scattering of laser light on high-energetic twisted electrons is investigated with the aim to construct spatially structured x-ray beams. In particular, we analyze how the properties of the twisted electrons, such as the topological charge and aperture angle of the electron Bessel beam, affects the energy and angular distribution of scattered x-rays. We show that with suitably chosen initial twisted electron states one can synthesize tailor-made x-ray beam profiles with a well-defined spatial structure, in a way not possible with ordinary plane-wave electron beams.

  6. X-Ray Scatter Correction on Soft Tissue Images for Portable Cone Beam CT

    OpenAIRE

    Sorapong Aootaphao; Saowapak S. Thongvigitmanee; Jartuwat Rajruangrabin; Chalinee Thanasupsombat; Tanapon Srivongsa; Pairash Thajchayapong

    2016-01-01

    Soft tissue images from portable cone beam computed tomography (CBCT) scanners can be used for diagnosis and detection of tumor, cancer, intracerebral hemorrhage, and so forth. Due to large field of view, X-ray scattering which is the main cause of artifacts degrades image quality, such as cupping artifacts, CT number inaccuracy, and low contrast, especially on soft tissue images. In this work, we propose the X-ray scatter correction method for improving soft tissue images. The X-ray scatter ...

  7. Generation of linearly polarized resonant transition radiation X-ray beam

    Energy Technology Data Exchange (ETDEWEB)

    Yajima, Kazuaki; Awata, Takaaki; Ikeda, Mitsuharu; Ikeda, Kenichi; Yogo, Akifumi; Itoh, Akio; Imanishi, Nobutsugu [Kyoto Univ. (Japan). Dept. of Nuclear Engineering

    2000-03-01

    We have proposed a method to generate almost linearly polarized resonant transition radiation X rays by using a rectangular slit placed on an electron beam axis. Our calculation predicted that the linearity is 93.5% for the resonant transition radiation X-ray beam extracted through a slit of 0.5 mrad long and 0.2 mrad wide in case of 1-GeV electron beam irradiating a 7.5-{mu}m thick Kapton foil stack. (author)

  8. Industrial X-ray tomography using an electron beam welding box

    CERN Document Server

    Hoppe, D; Koch, D; Zippe, C

    2002-01-01

    An existing electron beam welding box should be used with the least additional effort for X-ray tomography. Only a suitable anode, a simple device to turn the investigated object and one detector for X-rays are placed into the vacuum of the welding box. The information necessary to reconstruct tomograms should be derived only from the measurand of the detector.

  9. An investigation on some of the tumor treatment cases using x-rays and electron beams

    Science.gov (United States)

    Ucar, Burcu; Yigitoglu, Ibrahim; Arslan Kabalay, Ipek; Altiparmak, Duygu; Kilicaslan, Sinem

    2015-07-01

    In this work, we discussed some of the applications which X-rays and electron beam used in radiotherapy for tumor treatments. This study has been performed at Radiation Oncology Department, Medicine Faculty in Gaziosmanpasa University by using the VARIAN CLINICA DHX linear accelerator which is operated in the range of 6 MeV - 15 MeV. Processes for the treatments that X-rays used for pancreas, bladder and prostate tumors and the processes that the electron beam used for some of the derm tumors are studied. Effects of X-rays and electron beams to treatments process are examined and the obtained results are presented comparatively.

  10. Evaluation of the Beam Quality of Intraoral X-ray Equipment using Intraoral Standard Films

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Sub; Kwon, Hyok Rak; Sim, Woo Hyoun; Oh, Seung Hyoun; Lee, Ji Youn; Jeon, Kug Jin; Kim, Kee Deog; Park, Chang Seo [Dept. of Oral and Maxillofacial Radiology, College of Dentistry, Yensei University, Seoul (Korea, Republic of)

    2000-09-15

    This study was to evaluate the beam quality of intraoral X-ray equipment used at Yonsei University Dental Hospital (YUDH) using the half value layer (HVL) and the characteristic curve of intraoral standard X-ray film. The study was done using the intraoral X-ray equipment used at each clinical department at YUDH. Aluminum filter was used to determine the HVL. Intraoral standard film was used to get the characteristic curve of each intraoral X-ray equipment. Most of the HVLs of intraoral X-ray equipment were higher than the least recommended thickness, but the REX 601 model used at the operative dentistry department and the X-707 model used at the pediatric dentistry department had HVLs lower than the recommended thickness. The slopes of the characteristic curves of films taken using the PANPAS 601 model and REX 601 model at operative dentistry department, the X-70S model of prosthodontic dentistry department, and the REX 601 model at the student clinic were relatively low. HVL and the characteristic curve of X-ray film can be used to evaluate the beam quality of intraoral X-ray equipment. In order to get the best X-ray films with the least radiation exposure to patients and best diagnostic information in clinical dentistry, X-ray equipment should be managed in the planned and organized fashion.

  11. Development of a multi-lane X-ray mirror providing variable beam sizes.

    Science.gov (United States)

    Laundy, D; Sawhney, K; Nistea, I; Alcock, S G; Pape, I; Sutter, J; Alianelli, L; Evans, G

    2016-05-01

    Grazing incidence mirrors are used on most X-ray synchrotron beamlines to focus, collimate or suppress harmonics. Increasingly beamline users are demanding variable beam shapes and sizes at the sample position. We have now developed a new concept to rapidly vary the beam size and shape of a focused X-ray beam. The surface of an elliptically figured mirror is divided into a number of laterally separated lanes, each of which is given an additional longitudinal height profile calculated to shape the X-ray beam to a top-hat profile in the focal plane. We have now fabricated two prototype mirrors and present the results of metrology tests and measurements made with one of the mirrors focusing the X-rays on a synchrotron beamline. We envisage that such mirrors could be widely applied to rapid beam-size switching on many synchrotron beamlines.

  12. Visualization of X-ray Beam Using CdWO4 Crystal for Macromolecular Crystallography

    Directory of Open Access Journals (Sweden)

    Kazimierz J. Gofron

    2011-12-01

    Full Text Available In synchrotron diffraction experiments, it is typically assumed that the X-ray beam at the sample position is uniform, stable and has dimensions that are controlled by the focus and slits settings. As might be expected, this process is much more complex. We present here an investigation of the properties of a synchrotron X-ray beam at the sample position. The X-ray beam is visualized with a single crystal scintillator that converts X-ray photons into visible light photons, which can be imaged using Structure Biology Center (SBC on-axis and off-axis microscope optics. The X-ray penetration is dependent on the composition of the scintillator (especially the effective Z, and X-ray energy. Several scintillators have been used to visualize X-ray beams. Here we compare CdWO4, PbWO4, Bi4Ge3O12, Y3Al5O12:Ce (YAG:Ce, and Gd2O2S:Tb (phosphor. We determined that scintillator crystals made of CdWO4 and similar high-Z materials are best suited for the energy range (7–20 keV and are most suitable for beam visualization for macromolecular crystallography applications. These scintillators show excellent absorption, optical, and mechanical properties.

  13. TU-EF-207-03: Advances in Stationary Breast Tomosynthesis Using Distributed X-Ray Sources

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, O. [The University of North Carolina at Chapel Hill (United States)

    2015-06-15

    mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation.

  14. Coherent X-ray radiation excited by a diverging relativistic electron beam in a single crystal

    Energy Technology Data Exchange (ETDEWEB)

    Blazhevich, S. V., E-mail: noskovbupk@mail.ru; Noskov, A. V. [Belgorod State National Research University (Russian Federation)

    2015-05-15

    We develop a dynamic theory of coherent X-rays generated in a single-crystal wafer by a diverging relativistic electron beam. The dependence of the spectral-angular density of coherent X-ray radiation on the angle of divergence is analyzed for the case when the angular spread can be described by the 2D Gaussian distribution. The theory constructed here makes it possible to analyze coherent radiation for an arbitrary angular distribution of electrons in the beam as well.

  15. Versatile AFM setup combined with micro-focused X-ray beam

    CERN Document Server

    Slobodskyy, T; Tholapi, R; Liefeith, L; Fester, M; Sprung, M; Hansen, W

    2015-01-01

    Micro-focused X-ray beams produced by third generation synchrotron sources offer new perspective of studying strains and processes at nanoscale. Atomic force microscope setup combined with a micro-focused synchrotron beam allows precise positioning and nanomanipulation of nanostructures under illumination. In this paper, we report on integration of a portable commercial atomic force microscope setup into a hard X-ray synchrotron beamline. Details of design, sample alignment procedure and performance of the setup are presented.

  16. X-ray spectral determination by successive modifications of the beam intensity

    Energy Technology Data Exchange (ETDEWEB)

    Mainardi, R.T.; Barrea, R.A. (Universidad Nacional de Cordoba (Argentina). Facultad de Matematica, Astronomia y Fisica)

    1989-08-10

    A simple and practical indirect method to determine spectra from X-ray tubes has been developed on the basis of successive modifications of beam flux. The beam is either scattered at different angles or attenuated by metal foils and the intensity is measured by an ionization chamber. The data are analyzed by means of an interative program that solves a system of equations whose unknowns define a parametric fit of the X-ray spectrum. We have checked this method with simulated measurements of tabulated spectra, as well as with our own measurements on available X-ray apparatus and for several different applied voltages. (orig.).

  17. The application of a novel detector for X-ray diffraction study of breast cancer

    OpenAIRE

    Zheng, Y.

    2016-01-01

    Current imaging methods - mammography, digital breast tomosynthesis, ultrasound and magnetic resonance images (MRI), fail to provide an accurate breast tumour size measurement. X-ray diffraction (XRD) can provide better contrast than mammography and digital breast tomosynthesis, better spatial resolution than ultrasound and is more cost effective than MRI. However, its use is limited by high radiation dose. Previous breast XRD research often fails to investigate samples with a realistic thick...

  18. Non-invasive classification of breast microcalcifications using x-ray coherent scatter computed tomography

    Science.gov (United States)

    Ghammraoui, Bahaa; Popescu, Lucretiu M.

    2017-02-01

    We investigate the use of energy dispersive x-ray coherent scatter computed tomography (ED-CSCT) as a non-invasive diagnostic method to differentiate between type I and type II breast calcifications. This approach is sensitive to the differences of composition and internal crystal structure of different types of microcalcifications. The study is carried out by simulating a CSCT system with a scanning pencil beam, considering a polychromatic x-ray source and an energy-resolving photon counting detector. In a first step, the multidimensional angle and energy distributed CSCT data is reduced to the projection-space distributions of only a few components, corresponding to the expected target composition: adipose, glandular tissue, weddellite (calcium oxalate) for type I calcifications, and hydroxyapatite for type II calcifications. The maximum-likelihood estimation of scatter components algorithm used, operating in the projection space, takes into account the polychromatic source, the detector response function and the energy dependent attenuation. In the second step, component images are reconstructed from the corresponding estimated component projections using filtered backprojection. In a preliminary step the coherent scatter differential cross sections for hydroxyapatite and weddellite minerals were determined experimentally. The classification of type I or II calcifications is done using the relative contrasts of their components as the criterion. Simulation tests were carried out for different doses and energy resolutions for multiple realizations. The results were analyzed using relative/receiver operating characteristic methodology and show good discrimination ability at medium and higher doses. The noninvasive CSCT technique shows potential to further improve the breast diagnostic accuracy and reduce the number of breast biopsies.

  19. Using a tandem ionization chamber for quality control of X-ray beams

    Energy Technology Data Exchange (ETDEWEB)

    Yoshizumi, Maira T.; Caldas, Linda V.E., E-mail: mairaty@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    X-ray beam qualities are defined by both the mean energies and by the half-value layers (HVL). Many international protocols use the half-value layer and the beam voltage to characterize the X-ray beam quality. A quality control program for X-ray equipment includes the constancy check of beam qualities, i.e., the periodical verification of the half-value layer, which can be a time consumable procedure. A tandem ionization chamber, developed at Instituto de Pesquisas Energeticas e Nucleares, was used to determine the HVL and its constancy for five radiotherapy standard beam qualities. This ionization chamber is composed by two sensitive volumes with inner electrodes made of different materials: aluminum and graphite. The beam quality constancy check test was performed during two months and the maximum variation obtained was 1.24% for the radiation beam quality T-10. This result is very satisfactory according to national recommendations. (author)

  20. X-ray fluorescence and energy dispersive x-ray diffraction for the quantification of elemental concentrations in breast tissue.

    Science.gov (United States)

    Geraki, K; Farquharson, M J; Bradley, D A

    2004-01-07

    This paper presents improvements on a previously reported method for the measurement of elements in breast tissue specimens (Geraki et al 2002 Phys. Med. Biol. 47 2327-39). A synchrotron-based system was used for the detection of the x-ray fluorescence (XRF) emitted from iron, copper, zinc and potassium in breast tissue specimens, healthy and cancerous. Calibration models resulting from the irradiation of standard aqueous solutions were used for the quantification of the elements. The present developments concentrate on increasing the convergence between the tissue samples and the calibration models, therefore improving accuracy. For this purpose the composition of the samples in terms of adipose and fibrous tissue was evaluated, using an energy dispersive x-ray diffraction (EDXRD) system. The relationships between the attenuation and scatter properties of the two tissue components and water were determined through Monte Carlo simulations. The results from the simulations and the EDXRD measurements allowed the XRF data from each specimen to be corrected according to its composition. The statistical analysis of the elemental concentrations of the different groups of specimens reveals that all four elements are found in elevated levels in the tumour specimens. The increase is less pronounced for iron and copper and most for potassium and zinc. Other observed features include the substantial degree of inhomogeneity of elemental distributions within the volume of the specimens, varying between 4% and 36% of the mean, depending on the element and the type of the sample. The accuracy of the technique, based on the measurement of a standard reference material, proved to be between 3% and 22% depending on the element, which presents only a marginal improvement (1%-3%) compared to the accuracy of the previously reported results. The measurement precision was between 1% and 9% while the calculated uncertainties on the final elemental concentrations ranged between 10% and 16%.

  1. A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering

    Science.gov (United States)

    Round, A. R.; Wilkinson, S. J.; Hall, C. J.; Rogers, K. D.; Glatter, O.; Wess, T.; Ellis, I. O.

    2005-09-01

    Breast tissue collected from tumour samples and normal tissue from bi-lateral mastectomy procedures were examined using small angle x-ray scattering. Previous work has indicated that breast tissue disease diagnosis could be performed using small angle x-ray scattering (SAXS) from a synchrotron radiation source. The technique would be more useful to health services if it could be made to work using a conventional x-ray source. Consistent and reliable differences in x-ray scatter distributions were observed between samples from normal and tumour tissue samples using the laboratory based 'SAXSess' system. Albeit from a small number of samples, a sensitivity of 100% was obtained. This result encourages us to pursue the implementation of SAXS as a laboratory based diagnosis technique.

  2. A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering

    Energy Technology Data Exchange (ETDEWEB)

    Round, A R [Daresbury Laboratories, Warrington, WA4 4AD (United Kingdom); Wilkinson, S J [Daresbury Laboratories, Warrington, WA4 4AD (United Kingdom); Hall, C J [Daresbury Laboratories, Warrington, WA4 4AD (United Kingdom); Rogers, K D [Department of Materials and Medical Sciences, Cranfield University, Swindon, SN6 8LA (United Kingdom); Glatter, O [Department of Chemistry, University of Graz (Austria); Wess, T [School of Optometry and Vision Sciences, Cardiff University, Cardiff CF10 3NB, Wales (United Kingdom); Ellis, I O [Nottingham City Hospital, Nottingham (United Kingdom)

    2005-09-07

    Breast tissue collected from tumour samples and normal tissue from bi-lateral mastectomy procedures were examined using small angle x-ray scattering. Previous work has indicated that breast tissue disease diagnosis could be performed using small angle x-ray scattering (SAXS) from a synchrotron radiation source. The technique would be more useful to health services if it could be made to work using a conventional x-ray source. Consistent and reliable differences in x-ray scatter distributions were observed between samples from normal and tumour tissue samples using the laboratory based 'SAXSess' system. Albeit from a small number of samples, a sensitivity of 100% was obtained. This result encourages us to pursue the implementation of SAXS as a laboratory based diagnosis technique.

  3. First demonstration of X-ray mirrors using focused ion beam

    Science.gov (United States)

    Numazawa, Masaki; Ezoe, Yuichiro; Ishikawa, Kumi; Ogawa, Tomohiro; Sato, Mayu; Nakamura, Kasumi; Takeuchi, Kazuma; Terada, Masaru; Ohashi, Takaya; Mitsuda, Kazuhisa; Kelley, Ron; Murata, Kaoru

    2016-06-01

    We report on novel X-ray mirrors fabricated with a focused ion beam for future astronomical missions. We fabricated a test sample from a silicon wafer by forming six slits whose sidewalls were used as X-ray reflection surfaces. The six slits were designed with a size of 25 × 300 × 170 µm3 and with different inclination angles of 0 and ±1°. We examined X-ray reflection using three slits with different inclination angles at Al Kα 1.49 keV. Consequently, we demonstrated X-ray reflection from all the three slits. All the sidewalls have multiangular components with a microroughness of ˜1 nm rms. ˜30-45% of the total surface area is effective for X-ray reflection. We confirmed that the inclination angles are consistent with the designed values.

  4. An indirect method of X-ray spectra measurement by simultaneous attenuations of the scattered beam

    Energy Technology Data Exchange (ETDEWEB)

    Mainardi, Raul T. [Facultad de Matematica, Astronomia y Fisica (FaMAF), Universidad Nacional de Cordoba, Ciudad Universitaria, X5000HUA-Cordoba (Argentina)], E-mail: mainardi@famaf.unc.edu.ar; Bonzi, Edgardo V. [Facultad de Matematica, Astronomia y Fisica (FaMAF), Universidad Nacional de Cordoba, Ciudad Universitaria, X5000HUA-Cordoba (Argentina)

    2008-05-15

    Direct and indirect methods of X-ray spectra determination present obstacles to their practical use since they must position either the collimator-detector assembly or the attenuators-ionization chamber, respectively, along the X-ray beam direction. These arrangements require considerable space and in many instances the detectors promptly saturate. An indirect procedure, which overcomes the aforementioned problems, is developed. It consists of the scattering of the X-ray beam from a carbon disk, which is detected simultaneously by several detectors placed away from the beam. The X-ray flux reaching each of these detectors is attenuated in metal sheets of different thicknesses, thus obtaining simultaneously the attenuation curve values. A set of analytical equations are derived to calculate attenuation curves by taking into account all the absorption and elastic and inelastic scattering processes that a beam of photons undergoes when going from the X-ray tube to the detector. Users, even those who are not well acquainted with computer programming, can easily obtain the X-ray spectrum by a least square fitting of a measured attenuation curve to a previously derived analytical expression. A simulated Monte Carlo program of photon transport from the X-ray tube to the detector provided simulated attenuation curves data. Analytically calculated and simulated attenuation curves for the same input spectrum wholly overlap and furthermore, reconstructed spectra from both sets of curves for different kilovoltages are also in full agreement. Finally, in addition to the importance of having the detectors out of the beam direction, the proposed arrangement features other main advantages, namely, only one X-ray tube shot is needed to obtain the required data, the physical processes involved are very well known, analytical equations are easily interpreted, and the measuring apparatuses can be comparatively simple to assemble and operate.

  5. Surface profiling of X-ray mirrors for shaping focused beams.

    Science.gov (United States)

    Laundy, David; Alianelli, Lucia; Sutter, John; Evans, Gwyndaf; Sawhney, Kawal

    2015-01-26

    Grazing incidence mirrors are a standard optic for focusing X-rays. Active mirrors, whose surface profile can be finely adjusted, allow control of beam shape and size at the sample. However, progress towards their routine use for beam shaping has been hampered by the strong striations in reflected beams away from the focal plane. Re-entrant (partly concave and partly convex) surface modifications are proposed for shaping X-ray beams to a top-hat in the focal plane while reducing the striations caused by unavoidable polishing errors. A method for constructing such surfaces with continuous height and slope (but only piecewise continuous curvature) will be provided. Ray tracing and wave propagation calculations confirm its effectiveness. A mirror system is proposed allowing vertical beam sizes in the range 0.5 to 10μm. A prototype will be fabricated and is expected to have applications on many synchrotron X-ray beamlines.

  6. Characterization and control of femtosecond electron and X-ray beams at free-electron lasers

    Energy Technology Data Exchange (ETDEWEB)

    Behrens, Christopher

    2012-11-15

    X-ray free-electron lasers (FELs) open up new frontiers in photon science, and in order to take full advantage of these unique accelerator-based light sources, the characterization and control of the femtosecond electron and X-ray beams is essential. Within this cumulative thesis, recent results achieved within the active research field of femtosecond electron and X-ray beams at FELs are reported.The basic principles of X-ray FELs are described, and concepts of longitudinal electron beam diagnostics with femtosecond accuracy are covered. Experimental results obtained with a transverse deflecting structure (TDS) and spectroscopy of coherent terahertz radiation are presented, and the suppression of coherent optical radiation effects, required for diagnostics utilizing a TDS, is demonstrated. Control of the longitudinal phase space by using multiple radio frequencies for longitudinal electron beam tailoring is presented, and a new technique of reversible electron beam heating with two TDSs is described. For the characterization of femtosecond X-ray pulses, a novel method based on dedicated longitudinal phase space diagnostics for electron beams is introduced, and recent measurements with a streaking technique using external terahertz fields are presented.

  7. Method for beam hardening correction in quantitative computed X-ray tomography

    Science.gov (United States)

    Yan, Chye Hwang (Inventor); Whalen, Robert T. (Inventor); Napel, Sandy (Inventor)

    2001-01-01

    Each voxel is assumed to contain exactly two distinct materials, with the volume fraction of each material being iteratively calculated. According to the method, the spectrum of the X-ray beam must be known, and the attenuation spectra of the materials in the object must be known, and be monotonically decreasing with increasing X-ray photon energy. Then, a volume fraction is estimated for the voxel, and the spectrum is iteratively calculated.

  8. Scattering-compensated cone beam x-ray luminescence computed tomography

    Science.gov (United States)

    Gao, Peng; Rong, Junyan; Pu, Huangsheng; Liu, Wenlei; Liao, Qimei; Lu, Hongbing

    2016-04-01

    X-ray luminescence computed tomography (XLCT) opens new possibilities to perform molecular imaging with x-ray. It is a dual modality imaging technique based on the principle that some nanophosphors can emit near-infrared (NIR) light when excited by x-rays. The x-ray scattering effect is a great issue in both CT and XLCT reconstruction. It has been shown that if the scattering effect compensated, the reconstruction average relative error can be reduced from 40% to 12% in the in the pencil beam XLCT. However, the scattering effect in the cone beam XLCT has not been proved. To verify and reduce the scattering effect, we proposed scattering-compensated cone beam x-ray luminescence computed tomography using an added leading to prevent the spare x-ray outside the irradiated phantom in order to decrease the scattering effect. Phantom experiments of two tubes filled with Y2O3:Eu3+ indicated that the proposed method could reduce the scattering by a degree of 30% and can reduce the location error from 1.8mm to 1.2mm. Hence, the proposed method was feasible to the general case and actual experiments and it is easy to implement.

  9. Evaluation of x-ray diffraction enhanced imaging in the diagnosis of breast cancer.

    Science.gov (United States)

    Liu, Chenglin; Yan, Xiaohui; Zhang, Xinyi; Yang, Wentao; Peng, Weijun; Shi, Daren; Zhu, Peiping; Huang, Wanxia; Yuan, Qingxi

    2007-01-21

    The significance of the x-ray diffraction enhanced imaging (DEI) technique in the diagnosis of breast cancer and its feasibility in clinical medical imaging are evaluated. Different massive specimens including normal breast tissues, benign breast tumour tissues and malignant breast tumour tissues are imaged with the DEI method. The images are recorded respectively by CCD or x-ray film at different positions of the rocking curve and processed with a pixel-by-pixel algorithm. The characteristics of the DEI images about the normal and diseased tissues are compared. The rocking curves of a double-crystal diffractometer with various tissues are also studied. The differences in DEI images and their rocking curves are evaluated for early diagnosis of breast cancers.

  10. A multiple CCD X-ray detector and its first operation with synchrotron radiation X-ray beam

    CERN Document Server

    Suzuki, M; Kumasaka, T; Sato, K; Toyokawa, H; Aries, I F; Jerram, P A; Ueki, T

    1999-01-01

    A 4x4 array structure of 16 identical CCD X-ray detector modules, called the multiple CCD X-ray detector system (MCCDX), was submitted to its first synchrotron radiation experiment at the protein crystallography station of the RIKEN beamline (BL45XU) at the SPring-8 facility. An X-ray diffraction pattern of cholesterol powder was specifically taken in order to investigate the overall system performance.

  11. Beam hardening: Analytical considerations of the effective attenuation coefficient of x-ray tomography

    NARCIS (Netherlands)

    Alles, J.; Mudde, R.F.

    2007-01-01

    Polychromatic x-ray beams traveling though material are prone to beam hardening, i.e., the high energy part of the incident spectrum gets over represented when traveling farther into the material. This study discusses the concept of a mean attenuation coefficient in a formal way. The total energy fl

  12. Investigation of chemical vapour deposition diamond detectors by X- ray micro-beam induced current and X-ray micro-beam induced luminescence techniques

    CERN Document Server

    Olivero, P; Vittone, E; Fizzotti, F; Paolini, C; Lo Giudice, A; Barrett, R; Tucoulou, R

    2004-01-01

    Tracking detectors have become an important ingredient in high-energy physics experiments. In order to survive the harsh detection environment of the Large Hadron Collider (LHC), trackers need to have special properties. They must be radiation hard, provide fast collection of charge, be as thin as possible and remove heat from readout electronics. The unique properties of diamond allow it to fulfill these requirements. In this work we present an investigation of the charge transport and luminescence properties of "detector grade" artificial chemical vapour deposition (CVD) diamond devices developed within the CERN RD42 collaboration, performed by means of X-ray micro-beam induced current collection (XBICC) and X-ray micro- beam induced luminescence (XBIL) techniques. XBICC technique allows quantitative estimates of the transport parameters of the material to be evaluated and mapped with micrometric spatial resolution. In particular, the high resolution and sensitivity of the technique has allowed a quantitati...

  13. Non-invasive measurement of X-ray beam heating on a surrogate crystal sample.

    Science.gov (United States)

    Snell, Edward H; Bellamy, Henry D; Rosenbaum, Gerd; van der Woerd, Mark J

    2007-01-01

    Cryocooling is a technique routinely used to mitigate the effects of secondary radiation damage on macromolecules during X-ray data collection. Energy from the X-ray beam absorbed by the sample raises the temperature of the sample. How large is the temperature increase and does this reduce the effectiveness of cryocooling? Sample heating by the X-ray beam has been measured non-invasively for the first time by means of thermal imaging. Specifically, the temperature rise of 1 mm and 2 mm glass spheres (sample surrogates) exposed to an intense synchrotron X-ray beam and cooled in a laminar flow of nitrogen gas is experimentally measured. For the typical sample sizes, photon energies, fluxes, flux densities and exposure times used for macromolecular crystallographic data collection at third-generation synchrotron radiation sources and with the sample accurately centered in the cryostream, the heating by the X-ray beam is only a few degrees. This is not sufficient to raise the sample above the amorphous-ice/crystalline-ice transition temperature and, if the cryostream cools the sample to 100 K, not even enough to significantly enhance radiation damage from secondary effects.

  14. Time-delayed beam splitting with energy separation of x-ray channels

    Energy Technology Data Exchange (ETDEWEB)

    Stetsko, Yuri P.; Shvyd' ko, Yuri V.; Brian Stephenson, G. [Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439 (United States)

    2013-10-21

    We introduce a time-delayed beam splitting method based on the energy separation of x-ray photon beams. It is implemented and theoretically substantiated on an example of an x-ray optical scheme similar to that of the classical Michelson interferometer. The splitter/mixer uses Bragg-case diffraction from a thin diamond crystal. Another two diamond crystals are used as back-reflectors. Because of energy separation and a minimal number (three) of optical elements, the split-delay line has high efficiency and is simple to operate. Due to the high transparency of diamond crystal, the split-delay line can be used in a beam sharing mode at x-ray free-electron laser facilities.

  15. Time-delayed beam splitting with energy separation of x-ray channels

    CERN Document Server

    Stetsko, Yuri P; Stephenson, G Brian

    2013-01-01

    We introduce a time-delayed beam splitting method based on the energy separation of x-ray photon beams. It is implemented and theoretically substantiated on an example of an x-ray optical scheme similar to that of the classical Michelson interferometer. The splitter/mixer uses Bragg-case diffraction from a thin diamond crystal. Another two diamond crystals are used as back-reflectors. For energy separation the back-reflectors are set at slightly different temperatures and angular deviations from exact backscattering. Because of energy separation and a minimal number (three) of optical elements, the split-delay line has high efficiency and is simple to operate. Due to the high transparency of diamond crystal, the split-delay line can be used in a beam sharing mode at x-ray free-electron laser facilities. The delay line can be made more compact by adding a fourth crystal.

  16. Influence of the electron beam emittance on the polarization of a laser--electron X-ray generator

    CERN Document Server

    Artyukov, I A; Feshchenko, R M

    2016-01-01

    In this paper we analyze the polarization of the X-ray radiation coming from laser--electron X-ray generator (LEXG). We obtain general relations connecting the polarization state of outgoing X-ray radiation to the polarization state of laser beam as well as to the parameters of electron beam. We demonstrate that finite electron beam emittance causes a partial depolarization of initially fully polarized X-ray radiation even when the laser beam is fully polarized. We demonstrate with a number of numerical experiments that finite electron beam emittance can in some cases fundamentally alter the polarization state of X-ray radiation as compared to the polarization state of X-ray radiation scattered by electron beam with a zero emittance. Possible applications of polarized LEXG's radiation are discussed.

  17. Innovation and fusion of x-ray and optical tomography for mouse studies of breast cancer

    Science.gov (United States)

    Wang, Ge; Cong, Wenxiang; Yang, Qingsong; Pian, Qi; Zhu, Shouping; Liang, Jimin; Barroso, Margarida; Intes, Xavier

    2016-10-01

    For early detection and targeted therapy, receptor expression profiling is instrumental to classifying breast cancer into sub-groups. In particular, human epidermal growth factor receptor 2 (HER2) expression has been shown to have both prognostic and predictive values. Recently, an increasingly more complex view of HER2 in breast cancer has emerged from genome sequencing that highlights the role of inter- and intra-tumor heterogeneity in therapy resistance. Studies on such heterogeneity demand high-content, high-resolution functional and molecular imaging in vivo, which cannot be achieved using any single imaging tool. Clearly, there is a critical need to develop a multimodality approach for breast cancer imaging. Since 2006, grating-based x-ray imaging has been developed for much-improved x-ray images. In 2014, the demonstration of fluorescence molecular tomography (FMT) guided by x-ray grating-based micro-CT was reported with encouraging results and major drawbacks. In this paper, we propose to integrate grating-based x-ray tomography (GXT) and high-dimensional optical tomography (HOT) into the first-of-its-kind truly-fused GXT-HOT (pronounced as "Get Hot") system for imaging of breast tumor heterogeneity, HER2 expression and dimerization, and therapeutic response. The primary innovation lies in developing a brand-new high-content, high-throughput x-ray optical imager based on several contemporary techniques to have MRI-type soft tissue contrast, PET-like sensitivity and specificity, and micro-CT-equivalent resolution. This system consists of two orthogonal x-ray Talbot-Lau interferometric imaging chains and a hyperspectral time-resolved single-pixel optical imager. Both the system design and pilot results will be reported in this paper, along with relevant issues under further investigation.

  18. Optimization of propagation-based x-ray phase-contrast tomography for breast cancer imaging

    Science.gov (United States)

    Baran, P.; Pacile, S.; Nesterets, Y. I.; Mayo, S. C.; Dullin, C.; Dreossi, D.; Arfelli, F.; Thompson, D.; Lockie, D.; McCormack, M.; Taba, S. T.; Brun, F.; Pinamonti, M.; Nickson, C.; Hall, C.; Dimmock, M.; Zanconati, F.; Cholewa, M.; Quiney, H.; Brennan, P. C.; Tromba, G.; Gureyev, T. E.

    2017-03-01

    The aim of this study was to optimise the experimental protocol and data analysis for in-vivo breast cancer x-ray imaging. Results are presented of the experiment at the SYRMEP beamline of Elettra Synchrotron using the propagation-based phase-contrast mammographic tomography method, which incorporates not only absorption, but also x-ray phase information. In this study the images of breast tissue samples, of a size corresponding to a full human breast, with radiologically acceptable x-ray doses were obtained, and the degree of improvement of the image quality (from the diagnostic point of view) achievable using propagation-based phase-contrast image acquisition protocols with proper incorporation of x-ray phase retrieval into the reconstruction pipeline was investigated. Parameters such as the x-ray energy, sample-to-detector distance and data processing methods were tested, evaluated and optimized with respect to the estimated diagnostic value using a mastectomy sample with a malignant lesion. The results of quantitative evaluation of images were obtained by means of radiological assessment carried out by 13 experienced specialists. A comparative analysis was performed between the x-ray and the histological images of the specimen. The results of the analysis indicate that, within the investigated range of parameters, both the objective image quality characteristics and the subjective radiological scores of propagation-based phase-contrast images of breast tissues monotonically increase with the strength of phase contrast which in turn is directly proportional to the product of the radiation wavelength and the sample-to-detector distance. The outcomes of this study serve to define the practical imaging conditions and the CT reconstruction procedures appropriate for low-dose phase-contrast mammographic imaging of live patients at specially designed synchrotron beamlines.

  19. Maximum-likelihood estimation of scatter components algorithm for x-ray coherent scatter computed tomography of the breast

    Science.gov (United States)

    Ghammraoui, Bahaa; Badal, Andreu; Popescu, Lucretiu M.

    2016-04-01

    Coherent scatter computed tomography (CSCT) is a reconstructive x-ray imaging technique that yields the spatially resolved coherent-scatter cross section of the investigated object revealing structural information of tissue under investigation. In the original CSCT proposals the reconstruction of images from coherently scattered x-rays is done at each scattering angle separately using analytic reconstruction. In this work we develop a maximum likelihood estimation of scatter components algorithm (ML-ESCA) that iteratively reconstructs images using a few material component basis functions from coherent scatter projection data. The proposed algorithm combines the measured scatter data at different angles into one reconstruction equation with only a few component images. Also, it accounts for data acquisition statistics and physics, modeling effects such as polychromatic energy spectrum and detector response function. We test the algorithm with simulated projection data obtained with a pencil beam setup using a new version of MC-GPU code, a Graphical Processing Unit version of PENELOPE Monte Carlo particle transport simulation code, that incorporates an improved model of x-ray coherent scattering using experimentally measured molecular interference functions. The results obtained for breast imaging phantoms using adipose and glandular tissue cross sections show that the new algorithm can separate imaging data into basic adipose and water components at radiation doses comparable with Breast Computed Tomography. Simulation results also show the potential for imaging microcalcifications. Overall, the component images obtained with ML-ESCA algorithm have a less noisy appearance than the images obtained with the conventional filtered back projection algorithm for each individual scattering angle. An optimization study for x-ray energy range selection for breast CSCT is also presented.

  20. Maximum-likelihood estimation of scatter components algorithm for x-ray coherent scatter computed tomography of the breast.

    Science.gov (United States)

    Ghammraoui, Bahaa; Badal, Andreu; Popescu, Lucretiu M

    2016-04-21

    Coherent scatter computed tomography (CSCT) is a reconstructive x-ray imaging technique that yields the spatially resolved coherent-scatter cross section of the investigated object revealing structural information of tissue under investigation. In the original CSCT proposals the reconstruction of images from coherently scattered x-rays is done at each scattering angle separately using analytic reconstruction. In this work we develop a maximum likelihood estimation of scatter components algorithm (ML-ESCA) that iteratively reconstructs images using a few material component basis functions from coherent scatter projection data. The proposed algorithm combines the measured scatter data at different angles into one reconstruction equation with only a few component images. Also, it accounts for data acquisition statistics and physics, modeling effects such as polychromatic energy spectrum and detector response function. We test the algorithm with simulated projection data obtained with a pencil beam setup using a new version of MC-GPU code, a Graphical Processing Unit version of PENELOPE Monte Carlo particle transport simulation code, that incorporates an improved model of x-ray coherent scattering using experimentally measured molecular interference functions. The results obtained for breast imaging phantoms using adipose and glandular tissue cross sections show that the new algorithm can separate imaging data into basic adipose and water components at radiation doses comparable with Breast Computed Tomography. Simulation results also show the potential for imaging microcalcifications. Overall, the component images obtained with ML-ESCA algorithm have a less noisy appearance than the images obtained with the conventional filtered back projection algorithm for each individual scattering angle. An optimization study for x-ray energy range selection for breast CSCT is also presented.

  1. An upgraded experiment of X-ray photon-photon elastic scattering with a Laue-case beam collider

    CERN Document Server

    Yamaji, T; Yamazaki, T; Namba, T; Asai, S; Kobayashi, T; Tamasaku, K; Tanaka, Y; Inubushi, Y; Sawada, K; Yabashi, M; Ishikawa, T

    2016-01-01

    The new result of a photon-photon scattering experiment in the X-ray region is reported. An X-ray beam collider is used to divide and collide X-ray beams from an X-ray Free Electron Laser, SACLA. The sensitivity of the experiment is enhanced by an upgraded X-ray beam collider and improvement of the SACLA beam quality. The intensity of the colliding photon beams increased significantly, giving an integrated luminosity of (1.24 \\pm 0.08) \\times 10^{28} m^{-2}. No signal of scattered X rays was observed. The obtained 95% C.L. limit on the QED cross section is 1.9 \\times 10^{-27} m^2 at \\omega_{cms}=6.5 keV, which is more stringent by around three orders of magnitude than our previous result.

  2. Study on fundamental processes of laser welded metals observed with intense x-ray beams

    Science.gov (United States)

    Muramatsu, T.; Daido, H.; Shobu, T.; Takase, K.; Tsukimori, K.; Kureta, M.; Segawa, M.; Nishimura, A.; Suzuki, Y.; Kawachi, T.

    With use of photon techniques including visible light, soft and hard x-rays, precise fundamental laser welding processes in the repair and maintenance of nuclear plant engineering were reviewed mechanistically. We make discussions centered on the usefulness of an intense soft x-ray beams for evaluations of spatial residual strain distribution and welded metal convection behavior including the surface morphology. Numerical results obtained with a general purpose three-dimensional code SPLICE for the simulation of the welding and solidifying phenomena. Then it is concluded that the x-ray beam would be useful as one of the powerful tools for understanding the mechanisms of various complex phenomena with higher accuracy and higher resolution.

  3. Study on Compression Induced Contrast in X-ray Mammograms Using Breast Mimicking Phantoms

    Directory of Open Access Journals (Sweden)

    A. B. M. Aowlad Hossain

    2015-09-01

    Full Text Available X-ray mammography is commonly used to scan cancer or tumors in breast using low dose x-rays. But mammograms suffer from low contrast problem. The breast is compressed in mammography to reduce x-ray scattering effects. As tumors are stiffer than normal tissues, they undergo smaller deformation under compression. Therefore, image intensity at tumor region may change less than the background tissues. In this study, we try to find out compression induced contrast from multiple mammographic images of tumorous breast phantoms taken with different compressions. This is an extended work of our previous simulation study with experiment and more analysis. We have used FEM models for synthetic phantom and constructed a phantom using agar and n-propanol for simulation and experiment. The x-ray images of deformed phantoms have been obtained under three compression steps and a non-rigid registration technique has been applied to register these images. It is noticeably observed that the image intensity changes at tumor are less than those at surrounding which induce a detectable contrast. Addition of this compression induced contrast to the simulated and experimental images has improved their original contrast by a factor of about 1.4

  4. Femtosecond time-resolved X-ray absorption spectroscopy of liquid using a hard X-ray free electron laser in a dual-beam dispersive detection method.

    Science.gov (United States)

    Obara, Yuki; Katayama, Tetsuo; Ogi, Yoshihiro; Suzuki, Takayuki; Kurahashi, Naoya; Karashima, Shutaro; Chiba, Yuhei; Isokawa, Yusuke; Togashi, Tadashi; Inubushi, Yuichi; Yabashi, Makina; Suzuki, Toshinori; Misawa, Kazuhiko

    2014-01-13

    We present femtosecond time-resolved X-ray absorption spectroscopy of aqueous solution using a hard x-ray free electron laser (SACLA) and a synchronized Ti:sapphire laser. The instrumental response time is 200 fs, and the repetition rate of measurement is 10 Hz. A cylindrical liquid beam 100 μm in diameter of aqueous ammonium iron(III) oxalate solution is photoexcited at 400 nm, and the transient X-ray absorption spectra are measured in the K-edge region of iron, 7.10 - 7.26 keV, using a dual X-ray beam dispersive detection method. Each of the dual beams has the pulse energy of 1.4 μJ, and pump-induced absorbance change on the order of 10(-3) is successfully detected. The photoexcited iron complex exhibits a red shifted iron K-edge with the appearance time constant of 260 fs. The X-ray absorption difference spectra, with and without the pump pulses, are independent of time delay after 1.5 ps up to 100 ps, indicating that the photoexcited species is long-lived.

  5. A New Method to Measure the Divergence of X-Ray Beams from Capillaries

    Institute of Scientific and Technical Information of China (English)

    LIN Xiao-Yan; LI Yu-De; CHI Ji-Hong; LIU An-Dong; TAN Guo-Tai

    2006-01-01

    @@ A new method to measure the divergence of x-ray beams propagated out from several capillaries is introduced.This new method is based on Bragg's law and is proven efficiently by the experimental measurement with collimators and straight polycapillaries.

  6. Cone Beam X-ray Luminescence Computed Tomography Based on Bayesian Method.

    Science.gov (United States)

    Zhang, Guanglei; Liu, Fei; Liu, Jie; Luo, Jianwen; Xie, Yaoqin; Bai, Jing; Xing, Lei

    2017-01-01

    X-ray luminescence computed tomography (XLCT), which aims to achieve molecular and functional imaging by X-rays, has recently been proposed as a new imaging modality. Combining the principles of X-ray excitation of luminescence-based probes and optical signal detection, XLCT naturally fuses functional and anatomical images and provides complementary information for a wide range of applications in biomedical research. In order to improve the data acquisition efficiency of previously developed narrow-beam XLCT, a cone beam XLCT (CB-XLCT) mode is adopted here to take advantage of the useful geometric features of cone beam excitation. Practically, a major hurdle in using cone beam X-ray for XLCT is that the inverse problem here is seriously ill-conditioned, hindering us to achieve good image quality. In this paper, we propose a novel Bayesian method to tackle the bottleneck in CB-XLCT reconstruction. The method utilizes a local regularization strategy based on Gaussian Markov random field to mitigate the ill-conditioness of CB-XLCT. An alternating optimization scheme is then used to automatically calculate all the unknown hyperparameters while an iterative coordinate descent algorithm is adopted to reconstruct the image with a voxel-based closed-form solution. Results of numerical simulations and mouse experiments show that the self-adaptive Bayesian method significantly improves the CB-XLCT image quality as compared with conventional methods.

  7. Fourier domain image fusion for differential X-ray phase-contrast breast imaging.

    Science.gov (United States)

    Coello, Eduardo; Sperl, Jonathan I; Bequé, Dirk; Benz, Tobias; Scherer, Kai; Herzen, Julia; Sztrókay-Gaul, Anikó; Hellerhoff, Karin; Pfeiffer, Franz; Cozzini, Cristina; Grandl, Susanne

    2017-04-01

    X-Ray Phase-Contrast (XPC) imaging is a novel technology with a great potential for applications in clinical practice, with breast imaging being of special interest. This work introduces an intuitive methodology to combine and visualize relevant diagnostic features, present in the X-ray attenuation, phase shift and scattering information retrieved in XPC imaging, using a Fourier domain fusion algorithm. The method allows to present complementary information from the three acquired signals in one single image, minimizing the noise component and maintaining visual similarity to a conventional X-ray image, but with noticeable enhancement in diagnostic features, details and resolution. Radiologists experienced in mammography applied the image fusion method to XPC measurements of mastectomy samples and evaluated the feature content of each input and the fused image. This assessment validated that the combination of all the relevant diagnostic features, contained in the XPC images, was present in the fused image as well.

  8. Indirect-detection single-photon-counting x-ray detector for breast tomosynthesis

    Science.gov (United States)

    Jiang, Hao; Kaercher, Joerg; Durst, Roger

    2016-03-01

    X-ray mammography is a crucial screening tool for early identification of breast cancer. However, the overlap of anatomical features present in projection images often complicates the task of correctly identifying suspicious masses. As a result, there has been increasing interest in acquisition of volumetric information through digital breast tomosynthesis (DBT) which, compared to mammography, offers the advantage of depth information. Since DBT requires acquisition of many projection images, it is desirable that the noise in each projection image be dominated by the statistical noise of the incident x-ray quanta and not by the additive noise of the imaging system (referred to as quantum-limited imaging) and that the cumulative dose be as low as possible (e.g., no more than for a mammogram). Unfortunately, the electronic noise (~2000 electrons) present in current DBT systems based on active matrix, flat-panel imagers (AMFPIs) is still relatively high compared with modest x-ray gain of the a-Se and CsI:Tl x-ray converters often used. To overcome the modest signal-to-noise ratio (SNR) limitations of current DBT systems, we have developed a large-area x-ray imaging detector with the combination of an extremely low noise (~20 electrons) active-pixel CMOS and a specially designed high resolution scintillator. The high sensitivity and low noise of such system provides better SNR by at least an order of magnitude than current state-of-art AMFPI systems and enables x-ray indirect-detection single photon counting (SPC) at mammographic energies with the potential of dose reduction.

  9. Adjustable hollow-cone output x-ray beam from an ellipsoidal monocapillary with a pinhole and a beam stop.

    Science.gov (United States)

    Sun, Xue-Peng; Liu, Zhi-Gou; Yi, Long-Tao; Sun, Wei-Yun; Li, Fang-Zou; Jiang, Bo-Wen; Ma, Yong-Zhong; Sun, Tian-Xi

    2015-12-10

    A combined shading system (CSS) consisting of a beam stop and a pinhole is proposed to be used between an ellipsoidal monocapillary (EM) and a conventional laboratory x-ray source to obtain an adjustable hollow-cone output beam for different experiments with no need for changing the EM. The CSS can change the incident x-ray beam on the EM by adjusting the position of the beam stop and the pinhole, with the corresponding change of the output beam of the EM. In this study, the adjustable hollow-cone output x-ray beam of an 80-mm-long EM with a CSS was studied in detail with a laboratory Cu x-ray generator with a focal spot diameter of 50 μm. The adjustable range of the focal spot size of the EM was from 8.6 to 58.7 μm. The adjustable range of the gain of the focal spot of the EM was from 0 to 1350. The beam divergence of the hollow-cone output beam of the EM ranged from 6 to 16.75 mrad. The illumination angle of the hollow-cone output beam of the EM ranged from 0 to 5.95 mrad. In addition, the potential application of the proposed adjusting method in testing the performance of the EM is briefly discussed.

  10. Evaluation of mammographic X-ray beams using a phosphor plate

    Energy Technology Data Exchange (ETDEWEB)

    Bustos F, M.; Prata M, A., E-mail: mbustos@ufmg.br [Universidade Federal de Minas Gerais, Departamento de Engenharia Nuclear, Av. Pte. Antonio Carlos 6627, 31270-901 Pampulha, Belo Horizonte, Minas Gerais (Brazil)

    2016-10-15

    Currently, breast cancer is the second type of cancer more with higher overall incidence recorded in 2015, more than 57,000 new cases according to the National Cancer Institute of Brazil Mammography is now one of the imaging technique most widely used worldwide for the early diagnosis of breast cancer. The computed radiography (Cr) plates are used to obtain digital radiographs, and are widely used for digital mammogram production. This study aims to evaluate the variation response in the exposure of a Cr plate in mammography unit. For this study a mammography device model Graph A F Mammo, made by Vmi and a Cr plate, model Regius, were used for mammography. Experiments were made with two X-ray beams of 20 and 25 kV. Successive exposures of the Cr plate were made in a time range time from 0.5 to 2.5 s., to obtain unprocessed images .raw and subsequently make the measurement of time, air kerma and air kerma rate using a Ray Safe Xi meter. Five measurements for each exposure time were performed and the images were analyzed using the Image J software. A matrix of 21 x 21 pixels was selected in the central region of each image to obtain the intensity value, in grey scale, for each exposure time. From these data, a correlation of the degree of darkening was made with time and the air kerma. The behavior of the curves corresponding to the intensity average values of central pixels in relation to the exposure time and air kerma are similar for both voltages,showing an initially linear behavior and then a plate saturation region, whichever occurs first at the greatest value of the applied voltage. (Author)

  11. Development of high-resolution x-ray CT system using parallel beam geometry

    Energy Technology Data Exchange (ETDEWEB)

    Yoneyama, Akio, E-mail: akio.yoneyama.bu@hitachi.com; Baba, Rika [Central Research Laboratory, Hitachi Ltd., Hatoyama, Saitama (Japan); Hyodo, Kazuyuki [Institute of Materials Science, High Energy Accelerator Research Organization, Tsukuba, Ibaraki (Japan); Takeda, Tohoru [School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa (Japan); Nakano, Haruhisa; Maki, Koutaro [Department of Orthodontics, School of Dentistry Showa University, Ota-ku, Tokyo (Japan); Sumitani, Kazushi; Hirai, Yasuharu [Kyushu Synchrotron Light Research Center, Tosu, Saga (Japan)

    2016-01-28

    For fine three-dimensional observations of large biomedical and organic material samples, we developed a high-resolution X-ray CT system. The system consists of a sample positioner, a 5-μm scintillator, microscopy lenses, and a water-cooled sCMOS detector. Parallel beam geometry was adopted to attain a field of view of a few mm square. A fine three-dimensional image of birch branch was obtained using a 9-keV X-ray at BL16XU of SPring-8 in Japan. The spatial resolution estimated from the line profile of a sectional image was about 3 μm.

  12. Vagus nerve stimulator stability and interference on radiation oncology x-ray beams

    Science.gov (United States)

    Gossman, Michael S.; Ketkar, Amruta; Liu, Arthur K.; Olin, Bryan

    2012-10-01

    Five different models of Cyberonics, Inc. vagus nerve stimulation (VNS) therapy pulse generators were investigated for their stability under radiation and their ability to change the absorbed dose from incident radiation. X-ray beams of 6 MV and 18 MV were used to quantify these results up to clinical doses of 68-78 Gy delivered in a single fraction. In the first part, the effect on electronic stimulation signaling of each pulse generator was monitored during and immediately afterwards with computer interrogation. In the second part, the effects of having the pulse generators scatter or attenuate the x-ray beam was also characterized from dose calculations on a treatment planning system as well as from actual radiation measurements. Some device models were found to be susceptible to radiation interference when placed directly in the beam of high energy therapeutic x-ray radiation. While some models exhibited no effect at all, others showed an apparent loss of stimulation output immediately after radiation was experienced. Still, other models were observed to have a cumulative dose effect with a reduced output signal, followed by battery depletion above 49 Gy. Absorbed dose changes on computer underestimated attenuation by nearly half for both energies amongst all pulse generators, although the computer did depict the proper shape of the changed distribution of dose around the device. Measured attenuation ranged from 7.0% to 11.0% at 6 MV and 4.2% to 5.2% at 18 MV for x-rays. Processes of back-scatter and side-scatter were deemed negligible although recorded. Identical results from 6 MV and 18 MV x-ray beams conclude no neutron effect was induced for the 18 MV beam. As there were documented effects identified in this research regarding pulse generation, it emphasizes the importance of caution when considering radiation therapy on patients with implanted VNS devices with observed malfunctions consequential.

  13. Measurement of breast-tissue x-ray attenuation by spectral mammography: solid lesions

    Science.gov (United States)

    Fredenberg, Erik; Kilburn-Toppin, Fleur; Willsher, Paula; Moa, Elin; Danielsson, Mats; Dance, David R.; Young, Kenneth C.; Wallis, Matthew G.

    2016-04-01

    Knowledge of x-ray attenuation is essential for developing and evaluating x-ray imaging technologies. For instance, techniques to distinguish between cysts and solid tumours at mammography screening would be highly desirable to reduce recalls, but the development requires knowledge of the x-ray attenuation for cysts and tumours. We have previously measured the attenuation of cyst fluid using photon-counting spectral mammography. Data on x-ray attenuation for solid breast lesions are available in the literature, but cover a relatively wide range, likely caused by natural spread between samples, random measurement errors, and different experimental conditions. In this study, we have adapted a previously developed spectral method to measure the linear attenuation of solid breast lesions. A total of 56 malignant and 5 benign lesions were included in the study. The samples were placed in a holder that allowed for thickness measurement. Spectral (energy-resolved) images of the samples were acquired and the image signal was mapped to equivalent thicknesses of two known reference materials, which can be used to derive the x-ray attenuation as a function of energy. The spread in equivalent material thicknesses was relatively large between samples, which is likely to be caused mainly by natural variation and only to a minor extent by random measurement errors and sample inhomogeneity. No significant difference in attenuation was found between benign and malignant solid lesions. The separation between cyst-fluid and tumour attenuation was, however, significant, which suggests it may be possible to distinguish cystic from solid breast lesions, and the results lay the groundwork for a clinical trial. In addition, the study adds a relatively large sample set to the published data and may contribute to a reduction in the overall uncertainty in the literature.

  14. Generating Picosecond X-Ray Pulses with Beam Manipulation in Synchrotron Light Sources

    CERN Document Server

    Guo, Weiming; Harkay, Katherine C; Sajaev, Vadim; Yang Bing Xin

    2005-01-01

    The length of x-ray pulses generated by storage ring light sources is usually tens of picoseconds. For example, the value is 40 ps rms at the Advanced Photon Source (APS). Methods of x-ray pulse compression are of great interest at the APS. One possible method, per Zholents et al., is to tilt the electron bunch with deflecting rf cavities.* Alternately, we found that the electron bunch can develop a tilt after application of a vertical kick in the presence of nonzero chromaticity. After slicing, the x-ray pulse length is determined by the tilt angle and the vertical beam size. In principal, sub-picosecond pulses can be obtained at APS. To date we have observed 6 ps rms visible light pulses with a streak camera. Efforts are underway to attempt further compression of the x-ray pulse and to increase the brilliance. This method can be easily applied to any storage ring light sources to generate x-ray pulses up to two orders of magnitude shorter than the electron bunch length. In this paper, we will present the th...

  15. Electron beam-based sources of ultrashort x-ray pulses.

    Energy Technology Data Exchange (ETDEWEB)

    Zholents, A.; Accelerator Systems Division (APS)

    2010-09-30

    A review of various methods for generation of ultrashort x-ray pulses using relativistic electron beam from conventional accelerators is presented. Both spontaneous and coherent emission of electrons is considered. The importance of the time-resolved studies of matter at picosecond (ps), femtosecond (fs), and atttosecond (as) time scales using x-rays has been widely recognized including by award of a Nobel Prize in 1999 [Zewa]. Extensive reviews of scientific drivers can be found in [BES1, BES2, BES3, Lawr, Whit]. Several laser-based techniques have been used to generate ultrashort x-ray pulses including laser-driven plasmas [Murn, Alte, Risc, Rose, Zamp], high-order harmonic generation [Schn, Rund, Wang, Arpi], and laser-driven anode sources [Ande]. In addition, ultrafast streak-camera detectors have been applied at synchrotron sources to achieve temporal resolution on the picosecond time scale [Wulf, Lind1]. In this paper, we focus on a different group of techniques that are based on the use of the relativistic electron beam produced in conventional accelerators. In the first part we review several techniques that utilize spontaneous emission of electrons and show how solitary sub-ps x-ray pulses can be obtained at existing storage ring based synchrotron light sources and linacs. In the second part we consider coherent emission of electrons in the free-electron lasers (FELs) and review several techniques for a generation of solitary sub-fs x-ray pulses. Remarkably, the x-ray pulses that can be obtained with the FELs are not only significantly shorter than the ones considered in Part 1, but also carry more photons per pulse by many orders of magnitude.

  16. Measurements of fast electron beams and soft X-ray emission from plasma-focus experiments

    Directory of Open Access Journals (Sweden)

    Surała Władysław

    2016-06-01

    Full Text Available The paper reports results of the recent experimental studies of pulsed electron beams and soft X-rays in plasma-focus (PF experiments carried out within a modified PF-360U facility at the NCBJ, Poland. Particular attention was focused on time-resolved measurements of the fast electron beams by means of two different magnetic analyzers, which could record electrons of energy ranging from about 41 keV to about 715 keV in several (6 or 8 measuring channels. For discharges performed with the pure deuterium filling, many strong electron signals were recorded in all the measuring channels. Those signals were well correlated with the first hard X-ray pulse detected by an external scintillation neutron-counter. In some of the analyzer channels, electron spikes (lasting about dozens of nanoseconds and appearing in different instants after the current peculiarity (so-called current dip were also recorded. For several discharges, fast ion beams, which were emitted along the z-axis and recorded with nuclear track detectors, were also investigated. Those measurements confirmed a multibeam character of the ion emission. The time-integrated soft X-ray images, which were taken side-on by means of a pinhole camera and sensitive X-ray films, showed the appearance of some filamentary structures and so-called hot spots. The application of small amounts of admixtures of different heavy noble gases, i.e. of argon (4.8% volumetric, krypton (1.6% volumetric, or xenon (0.8% volumetric, decreased intensity of the recorded electron beams, but increased intensity of the soft X-ray emission and showed more distinct and numerous hot spots. The recorded electron spikes have been explained as signals produced by quasi-mono-energetic microbeams emitted from tiny sources (probably plasma diodes, which can be formed near the observed hot spots.

  17. Combined measurement of X-ray photon correlation spectroscopy and diffracted X-ray tracking using pink beam X-rays.

    Science.gov (United States)

    Shinohara, Yuya; Watanabe, Akira; Kishimoto, Hiroyuki; Amemiya, Yoshiyuki

    2013-09-01

    Combined X-ray photon correlation spectroscopy (XPCS) and diffracted X-ray tracking (DXT) measurements of carbon-black nanocrystals embedded in styrene-butadiene rubber were performed. From the intensity fluctuation of speckle patterns in a small-angle scattering region (XPCS), dynamical information relating to the translational motion can be obtained, and the rotational motion is observed through the changes in the positions of DXT diffraction spots. Graphitized carbon-black nanocrystals in unvulcanized styrene-butadiene rubber showed an apparent discrepancy between their translational and rotational motions; this result seems to support a stress-relaxation model for the origin of super-diffusive particle motion that is widely observed in nanocolloidal systems. Combined measurements using these two techniques will give new insights into nanoscopic dynamics, and will be useful as a microrheology technique.

  18. Enhancement of laser to X-ray conversion by counter-propagating laser beams irradiating thin gold targets

    Science.gov (United States)

    Zhao, Y.; Ge, Z. Y.; Ma, Y. Y.; Yang, X. H.; Xu, B. B.; Ramis, R.

    2017-03-01

    X-ray emission from laser irradiating solid target is an important X-ray source for various potential applications. Counter-propagating (C-P) laser beams configuration is proposed to enhance the laser to X-ray conversion efficiency (CE) from laser irradiating solid targets. One-dimensional radiation hydrodynamics simulations show that the total X-ray CE for the C-P lasers case is as high as 65%, which has a 13% improvement compared with the single laser case. The improvement is mainly caused by the enlarged radiation region, and the enhancement of X-ray emission is from soft X-ray. Detailed energy term distributions and influences of the foil thickness on the X-ray CEs for both cases are presented. It is found that the enhancement of radiation is attributed to lower thermal and kinetic energy of the C-P lasers scheme.

  19. 3D localization of electrophysiology catheters from a single x-ray cone-beam projection

    Energy Technology Data Exchange (ETDEWEB)

    Robert, Normand, E-mail: normand.robert@sri.utoronto.ca; Polack, George G.; Sethi, Benu; Rowlands, John A. [Physical Sciences, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5 (Canada); Crystal, Eugene [Division of Cardiology, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5 (Canada)

    2015-10-15

    Purpose: X-ray images allow the visualization of percutaneous devices such as catheters in real time but inherently lack depth information. The provision of 3D localization of these devices from cone beam x-ray projections would be advantageous for interventions such as electrophysiology (EP), whereby the operator needs to return a device to the same anatomical locations during the procedure. A method to achieve real-time 3D single view localization (SVL) of an object of known geometry from a single x-ray image is presented. SVL exploits the change in the magnification of an object as its distance from the x-ray source is varied. The x-ray projection of an object of interest is compared to a synthetic x-ray projection of a model of said object as its pose is varied. Methods: SVL was tested with a 3 mm spherical marker and an electrophysiology catheter. The effect of x-ray acquisition parameters on SVL was investigated. An independent reference localization method was developed to compare results when imaging a catheter translated via a computer controlled three-axes stage. SVL was also performed on clinical fluoroscopy image sequences. A commercial navigation system was used in some clinical image sequences for comparison. Results: SVL estimates exhibited little change as x-ray acquisition parameters were varied. The reproducibility of catheter position estimates in phantoms denoted by the standard deviations, (σ{sub x}, σ{sub y}, σ{sub z}) = (0.099 mm,  0.093 mm,  2.2 mm), where x and y are parallel to the detector plane and z is the distance from the x-ray source. Position estimates (x, y, z) exhibited a 4% systematic error (underestimation) when compared to the reference method. The authors demonstrated that EP catheters can be tracked in clinical fluoroscopic images. Conclusions: It has been shown that EP catheters can be localized in real time in phantoms and clinical images at fluoroscopic exposure rates. Further work is required to characterize

  20. Electron beam stability and beam peak to peak motion data for NSLS X-Ray storage ring

    Energy Technology Data Exchange (ETDEWEB)

    Singh, O.

    1993-07-01

    In the past two years, a significant reduction in electron beam motion has been achieved at the NSLS X-Ray storage ring. The implementation of global analog orbit feedbacks, based on a harmonics correction scheme, has reduced the beam motion globally. Implementation of six local analog feedback systems has reduced the beam motion even further at the corresponding beam line straight sections. This paper presents beam motion measurements, showing the improvement due to the feedback systems. Beam motion is measured using a spectrum analyzer and data is presented at various frequencies, where peaks were observed. Finally, some of the beam motion sources are discussed.

  1. In situ surface/interface x-ray diffractometer for oxide molecular beam epitaxy

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. H.; Freeland, J. W.; Hong, Hawoong, E-mail: hhong@aps.anl.gov [Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439 (United States); Tung, I. C. [Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439 (United States); Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208 (United States); Chang, S.-H.; Bhattacharya, A.; Fong, D. D. [Materials Science Division, Argonne National Laboratory, Argonne, Illinois 60439 (United States)

    2016-01-15

    In situ studies of oxide molecular beam epitaxy by synchrotron x-ray scattering has been made possible by upgrading an existing UHV/molecular beam epitaxy (MBE) six-circle diffractometer system. For oxide MBE growth, pure ozone delivery to the chamber has been made available, and several new deposition sources have been made available on a new 12 in. CF (ConFlat, a registered trademark of Varian, Inc.) flange. X-ray diffraction has been used as a major probe for film growth and structures for the system. In the original design, electron diffraction was intended for the secondary diagnostics available without the necessity of the x-ray and located at separate positions. Deposition of films was made possible at the two diagnostic positions. And, the aiming of the evaporation sources is fixed to the point between two locations. Ozone can be supplied through two separate nozzles for each location. Also two separate thickness monitors are installed. Additional features of the equipment are also presented together with the data taken during typical oxide film growth to illustrate the depth of information available via in situ x-ray techniques.

  2. In situ surface/interface x-ray diffractometer for oxide molecular beam epitaxy

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. H. [Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439, USA; Tung, I. C. [Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439, USA; Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA; Chang, S. -H. [Materials Science Division, Argonne National Laboratory, Argonne, Illinois 60439, USA; Bhattacharya, A. [Materials Science Division, Argonne National Laboratory, Argonne, Illinois 60439, USA; Fong, D. D. [Materials Science Division, Argonne National Laboratory, Argonne, Illinois 60439, USA; Freeland, J. W. [Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439, USA; Hong, Hawoong [Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439, USA

    2016-01-01

    In situ studies of oxide molecular beam epitaxy by synchrotron x-ray scattering has been made possible by upgrading an existing UHV/molecular beam epitaxy (MBE) six-circle diffractometer system. For oxide MBE growth, pure ozone delivery to the chamber has been made available, and several new deposition sources have been made available on a new 12 in. CF (ConFlat, a registered trademark of Varian, Inc.) flange. X-ray diffraction has been used as a major probe for film growth and structures for the system. In the original design, electron diffraction was intended for the secondary diagnostics available without the necessity of the x-ray and located at separate positions. Deposition of films was made possible at the two diagnostic positions. And, the aiming of the evaporation sources is fixed to the point between two locations. Ozone can be supplied through two separate nozzles for each location. Also two separate thickness monitors are installed. Additional features of the equipment are also presented together with the data taken during typical oxide film growth to illustrate the depth of information available via in situ x-ray techniques.

  3. LabVIEW control software for scanning micro-beam X-ray fluorescence spectrometer.

    Science.gov (United States)

    Wrobel, Pawel; Czyzycki, Mateusz; Furman, Leszek; Kolasinski, Krzysztof; Lankosz, Marek; Mrenca, Alina; Samek, Lucyna; Wegrzynek, Dariusz

    2012-05-15

    Confocal micro-beam X-ray fluorescence microscope was constructed. The system was assembled from commercially available components - a low power X-ray tube source, polycapillary X-ray optics and silicon drift detector - controlled by an in-house developed LabVIEW software. A video camera coupled to optical microscope was utilized to display the area excited by X-ray beam. The camera image calibration and scan area definition software were also based entirely on LabVIEW code. Presently, the main area of application of the newly constructed spectrometer is 2-dimensional mapping of element distribution in environmental, biological and geological samples with micrometer spatial resolution. The hardware and the developed software can already handle volumetric 3-D confocal scans. In this work, a front panel graphical user interface as well as communication protocols between hardware components were described. Two applications of the spectrometer, to homogeneity testing of titanium layers and to imaging of various types of grains in air particulate matter collected on membrane filters, were presented.

  4. In situ surface/interface x-ray diffractometer for oxide molecular beam epitaxy.

    Science.gov (United States)

    Lee, J H; Tung, I C; Chang, S-H; Bhattacharya, A; Fong, D D; Freeland, J W; Hong, Hawoong

    2016-01-01

    In situ studies of oxide molecular beam epitaxy by synchrotron x-ray scattering has been made possible by upgrading an existing UHV/molecular beam epitaxy (MBE) six-circle diffractometer system. For oxide MBE growth, pure ozone delivery to the chamber has been made available, and several new deposition sources have been made available on a new 12 in. CF (ConFlat, a registered trademark of Varian, Inc.) flange. X-ray diffraction has been used as a major probe for film growth and structures for the system. In the original design, electron diffraction was intended for the secondary diagnostics available without the necessity of the x-ray and located at separate positions. Deposition of films was made possible at the two diagnostic positions. And, the aiming of the evaporation sources is fixed to the point between two locations. Ozone can be supplied through two separate nozzles for each location. Also two separate thickness monitors are installed. Additional features of the equipment are also presented together with the data taken during typical oxide film growth to illustrate the depth of information available via in situ x-ray techniques.

  5. X-Ray Scatter Correction on Soft Tissue Images for Portable Cone Beam CT

    Directory of Open Access Journals (Sweden)

    Sorapong Aootaphao

    2016-01-01

    Full Text Available Soft tissue images from portable cone beam computed tomography (CBCT scanners can be used for diagnosis and detection of tumor, cancer, intracerebral hemorrhage, and so forth. Due to large field of view, X-ray scattering which is the main cause of artifacts degrades image quality, such as cupping artifacts, CT number inaccuracy, and low contrast, especially on soft tissue images. In this work, we propose the X-ray scatter correction method for improving soft tissue images. The X-ray scatter correction scheme to estimate X-ray scatter signals is based on the deconvolution technique using the maximum likelihood estimation maximization (MLEM method. The scatter kernels are obtained by simulating the PMMA sheet on the Monte Carlo simulation (MCS software. In the experiment, we used the QRM phantom to quantitatively compare with fan-beam CT (FBCT data in terms of CT number values, contrast to noise ratio, cupping artifacts, and low contrast detectability. Moreover, the PH3 angiography phantom was also used to mimic human soft tissues in the brain. The reconstructed images with our proposed scatter correction show significant improvement on image quality. Thus the proposed scatter correction technique has high potential to detect soft tissues in the brain.

  6. Thermoluminescence of zirconium oxide nanostructured to mammography X-ray beams

    Energy Technology Data Exchange (ETDEWEB)

    Palacios, L.L. [Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada-Legaria, IPN. Av. Legaria 694, 11500 Mexico D.F. (Mexico); Rivera, T., E-mail: trivera@ipn.mx [Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada-Legaria, IPN. Av. Legaria 694, 11500 Mexico D.F. (Mexico); Roman, J. [Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada-Legaria, IPN. Av. Legaria 694, 11500 Mexico D.F. (Mexico); Azorin, J. [Universidad Autonoma Metropolitana-Iztapalapa. Av. San Rafael Atlixco 187, 09340 Mexico D.F. (Mexico); Gaona, E. [Universidad Autonoma Metropolitana-Xochimilco. Calz. Del Hueso 1100, 04960 Mexico D.F. (Mexico)

    2012-07-15

    In the present work thermoluminescent (TL) response of zirconium oxide (ZrO{sub 2}) nanostructured induced by mammography X-ray radiation was investigated. Measurements were made of the response per unit air kerma of ZrO{sub 2} with mammography equipment parameters (semiautomatic exposure control, 24 kVp and 108 mAs). The calibration curves were obtained by simultaneously irradiating ZrO{sub 2} samples and ion chamber. Samples of ZrO{sub 2} showed a linear response as a function of entrance skin air kerma. The observed results in TL properties suggest that ZrO{sub 2} nanostructured could be considered as an effective material for X-ray beams dosimetry if appropriate calibration procedures are performed. - Highlights: Black-Right-Pointing-Pointer X-ray low energy thermoluminescent of ZrO{sub 2} dosimeter is developed. Black-Right-Pointing-Pointer Air kerma measurements were made by thermoluminescent dosimeter ZrO{sub 2} using mammography equipment parameters. Black-Right-Pointing-Pointer Entrance surface skin doses were made using thermoluminescent dosimeter of ZrO{sub 2} to X-ray beam quality control.

  7. X-ray beam monitor made by thin-film CVD single-crystal diamond.

    Science.gov (United States)

    Marinelli, Marco; Milani, E; Prestopino, G; Verona, C; Verona-Rinati, G; Angelone, M; Pillon, M; Kachkanov, V; Tartoni, N; Benetti, M; Cannatà, D; Di Pietrantonio, F

    2012-11-01

    A novel beam position monitor, operated at zero bias voltage, based on high-quality chemical-vapor-deposition single-crystal Schottky diamond for use under intense synchrotron X-ray beams was fabricated and tested. The total thickness of the diamond thin-film beam monitor is about 60 µm. The diamond beam monitor was inserted in the B16 beamline of the Diamond Light Source synchrotron in Harwell (UK). The device was characterized under monochromatic high-flux X-ray beams from 6 to 20 keV and a micro-focused 10 keV beam with a spot size of approximately 2 µm × 3 µm square. Time response, linearity and position sensitivity were investigated. Device response uniformity was measured by a raster scan of the diamond surface with the micro-focused beam. Transmissivity and spectral responsivity versus beam energy were also measured, showing excellent performance of the new thin-film single-crystal diamond beam monitor.

  8. The X-Ray Beam Imager for Transversal Profiling of Low-Emittance Electron Beam at the SPring-8

    CERN Document Server

    Takano, S; Ohkuma, H

    2005-01-01

    We have developed the X-ray beam imager (XBI) at the accelerator diagnostics beamline I of the SPring-8 to observe transverse profiles of small electron beam of a low-emittance synchrotron light source. The XBI is based on a single Fresnel zone plate (FZP) and an X-ray zooming tube (XZT). The electron beam moving in a bending magnet is imaged by the FZP. Monochromatic X-ray is selected by a double crystal monochromator to avoid the effect of chromatic aberration of the FZP. The X-ray images of the electron beam obtained are converted by the XZT to enlarged images in visible light. The XBI has achieved a superior 1 σ spatial resolution in the micron range, and a fast time resolution of 1 ms. It has also realized a vignetting-free field of view larger than 1.5 mm in diameter on the coordinates of the electron beam, which is not easily obtained by imaging optics using two FZPs. With the XBI, we have successfully measured the profiles of the small electron beam having low vertical emittance in the pm ra...

  9. Characterization of materials for optimal near-infrared and x-ray imaging of the breast.

    Science.gov (United States)

    Michaelsen, Kelly; Krishnaswamy, Venkataramanan; Pogue, Brian W; Brooks, Ken; Defreitas, Ken; Shaw, Ian; Poplack, Steven P; Paulsen, Keith D

    2012-09-01

    Development of a detector case for complete co-registration of images in a non-fiber-based combined near-infrared spectral tomography and digital breast tomosynthesis, required analysis to find materials that could support a breast under full mammographic compression without affecting the x-ray images or the quality of the near infrared measurements. Several possible solutions were considered, and many types of plastics were tested in the development of the detector case. Light channeling within the detector case changed the data obtained in resin and agarose phantoms, lowering recovered absorption values. Additional developments focusing on blocking stray light were successful and permitted a normal subject imaging exam.

  10. Intrinsic beam emittance of laser-accelerated electrons measured by x-ray spectroscopic imaging.

    Science.gov (United States)

    Golovin, G; Banerjee, S; Liu, C; Chen, S; Zhang, J; Zhao, B; Zhang, P; Veale, M; Wilson, M; Seller, P; Umstadter, D

    2016-04-19

    The recent combination of ultra-intense lasers and laser-accelerated electron beams is enabling the development of a new generation of compact x-ray light sources, the coherence of which depends directly on electron beam emittance. Although the emittance of accelerated electron beams can be low, it can grow due to the effects of space charge during free-space propagation. Direct experimental measurement of this important property is complicated by micron-scale beam sizes, and the presence of intense fields at the location where space charge acts. Reported here is a novel, non-destructive, single-shot method that overcame this problem. It employed an intense laser probe pulse, and spectroscopic imaging of the inverse-Compton scattered x-rays, allowing measurement of an ultra-low value for the normalized transverse emittance, 0.15 (±0.06) π mm mrad, as well as study of its subsequent growth upon exiting the accelerator. The technique and results are critical for designing multi-stage laser-wakefield accelerators, and generating high-brightness, spatially coherent x-rays.

  11. National Synchrotron Light Source users manual: Guide to the VUV and x-ray beam lines

    Energy Technology Data Exchange (ETDEWEB)

    Gmuer, N.F.; White-DePace, S.M. (eds.)

    1987-08-01

    The success of the National Synchrotron Light Source in the years to come will be based, in large part, on the size of the users community and the diversity of the scientific disciplines represented by these users. In order to promote this philosophy, this National Synchrotron Light Source (NSLS) Users Manual: Guide to the VUV and X-Ray Beam Lines, has been published. This manual serves a number of purposes. In an effort to attract new research, it will present to the scientific community-at-large the current and projected architecture and capabilities of the various VUV and x-ray beam lines and storage rings. We anticipate that this publication will be updated periodically in order to keep pace with the constant changes at the NSLS.

  12. A compact x-ray beam intensity monitor using gas amplified sample current measurement

    Science.gov (United States)

    Hayakawa, Shinjiro; Kobayashi, Kazuo; Gohshi, Yohichi

    2000-01-01

    Development of a compact beam intensity monitor using gas amplified sample current measurement is described. The monitor can be a powerful tool for x-ray spectroscopy and microscopy when the beam is defined by a small pinhole or slits and when the workspace around the sample is limited. The thickness of the monitor is as small as approximately 3 mm, and the dimension is 10 mm square. The photon flux is monitored by measuring x-ray excited current from an Al foil under atmospheric conditions. Emitted electrons from the Al foil can ionize surrounding air molecules, and the gas amplified current can be measured with the use of a biased grid that prevents created ion pairs from recombination.

  13. Matching X-ray beam and detector properties to protein crystals of different perfection

    Energy Technology Data Exchange (ETDEWEB)

    Nave, Colin, E-mail: colin.nave@diamond.ac.uk [Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0DE (United Kingdom)

    2014-03-18

    Expressions are given to match X-ray data collection facilities to the intrinsic diffraction properties of crystals with different degrees of perfection. An analysis is given of the effect of different beam and detector parameters on the sharpness of recorded diffraction features for macromolecular crystals of different quality. The crystal quality parameters include crystal strain, crystal or mosaic block size and mosaic block misorientation. Calculations are given for instrument parameters such as angular resolution of the detector, beam divergence and wavelength bandpass to be matched to the intrinsic diffraction properties from these crystals with the aim of obtaining the best possible data out of each crystal. Examples are given using typical crystal imperfections obtained from the literature for both room-temperature and cryo-cooled crystals. Possible implications for the choice of X-ray source, beamline design, detector specifications, instrument set-up and data processing are discussed, together with the limitations of the approach.

  14. X-ray scattering for the characterization of lyophilized breast tissue samples

    Science.gov (United States)

    Elshemey, Wael M.; Mohamed, Fayrouz S.; Khater, Ibrahim M.

    2013-09-01

    This work investigates the possibility of characterizing breast cancer by measuring the X-ray scattering profiles of lyophilized excised breast tissue samples. Since X-ray scattering from water-rich tissue is dominated by scattering from water, the removal of water by lyophilization would enhance the characterization process. In the present study, X-ray scattering profiles of 22 normal, 22 malignant and 10 benign breast tissue samples are measured. The cut-offs of scatter diagrams, sensitivity, specificity and diagnostic accuracy of three characterization parameters (full width at half maximum (FWHM) for the peak at 1.1 nm-1, area under curve (AUC), and ratio of 1st to 2nd scattering peak intensities (I1/I2%)) are calculated and compared to the data from non-lyophilized samples. Results show increased sensitivity (up to 100%) of the present data on lyophilized breast tissue samples compared to previously reported data for non-lyophilized samples while the specificity (up to 95.4%), diagnostic accuracy (up to 95.4%) and receiver operating characteristic (ROC) curve values (up to 0.9979) for both sets of data are comparable. The present study shows significant differences between normal samples and each of malignant and benign samples. Only subtle differences exist between malignant and benign lyophilized breast tissue samples where FWHM=0.7±0.1 and 0.8±0.3, AUC=1.3±0.2 and 1.4±0.2 and I1/I2%=44.9±11.0 and 52.4±7.6 for malignant and benign samples respectively.

  15. Experimental characterization of X-ray transverse coherence in the presence of beam transport optics

    DEFF Research Database (Denmark)

    Chubar, O.; Fluerasu, A.; Chu, Y.S.

    2013-01-01

    be significantly affected by the new shape of the focused beam phase-space. At the same time, optical element imperfections still have a negative impact on the transverse coherence. In such situations, which are frequently encountered in experiments at beamlines, the quantitative interpretation of a measured...... propagation based simulations show, in particular, that new generation 1D Beryllium Compound Refractive Lenses [3, 4] do not reduce the X-ray transverse coherence in any significant manner. © 2013 IOP Publishing Ltd....

  16. Functional characterization of planar sensors with active edges using laser and X-ray beam scans

    Energy Technology Data Exchange (ETDEWEB)

    Povoli, M., E-mail: povoli@disi.unitn.it [Dipartimento di Ingegneria e Scienza dell' Informazione, Università di Trento, Via Sommarive, 14, I-38123 Povo di Trento (Italy); INFN, Sezione di Padova (Gruppo Collegato di Trento),Via Sommarive, 14, I-38123 Povo di Trento (Italy); Bagolini, A.; Boscardin, M. [Fondazione Bruno Kessler, Centro per i Materiali e i Microsistemi (FBK-CMM), Via Sommarive, 18, I-38123 Povo di Trento (Italy); Dalla Betta, G.-F. [Dipartimento di Ingegneria e Scienza dell' Informazione, Università di Trento, Via Sommarive, 14, I-38123 Povo di Trento (Italy); INFN, Sezione di Padova (Gruppo Collegato di Trento),Via Sommarive, 14, I-38123 Povo di Trento (Italy); Giacomini, G. [Fondazione Bruno Kessler, Centro per i Materiali e i Microsistemi (FBK-CMM), Via Sommarive, 18, I-38123 Povo di Trento (Italy); Hasi, J. [SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025-7015 (United States); Oh, A. [The University of Manchester, Oxford Road, Manchester M13 9PL (United Kingdom); Zorzi, N. [Fondazione Bruno Kessler, Centro per i Materiali e i Microsistemi (FBK-CMM), Via Sommarive, 18, I-38123 Povo di Trento (Italy)

    2013-08-01

    We report on the functional characterization of planar sensors with active edges fabricated at Fondazione Bruno Kessler (FBK), Trento, Italy. The measurements here reported were performed by means of laser and X-ray beam scans mainly focusing on the signal efficiency of the edge region of the devices. Results are very encouraging and show very good sensitivity up to few microns away from the device physical edge.

  17. Impact of large x-ray beam collimation on image quality

    Science.gov (United States)

    Racine, Damien; Ba, Alexandre; Ott, Julien G.; Bochud, François O.; Verdun, Francis R.

    2016-03-01

    Large X-ray beam collimation in computed tomography (CT) opens the way to new image acquisition techniques and improves patient management for several clinical indications. The systems that offer large X-ray beam collimation enable, in particular, a whole region of interest to be investigated with an excellent temporal resolution. However, one of the potential drawbacks of this option might be a noticeable difference in image quality along the z-axis when compared with the standard helical acquisition mode using more restricted X-ray beam collimations. The aim of this project is to investigate the impact of the use of large X-ray beam collimation and new iterative reconstruction on noise properties, spatial resolution and low contrast detectability (LCD). An anthropomorphic phantom and a custom made phantom were scanned on a GE Revolution CT. The images were reconstructed respectively with ASIR-V at 0% and 50%. Noise power spectra, to evaluate the noise properties, and Target Transfer Functions, to evaluate the spatial resolution, were computed. Then, a Channelized Hotelling Observer with Gabor and Dense Difference of Gaussian channels was used to evaluate the LCD using the Percentage correct as a figure of merit. Noticeable differences of 3D noise power spectra and MTF have been recorded; however no significant difference appeared when dealing with the LCD criteria. As expected the use of iterative reconstruction, for a given CTDIvol level, allowed a significant gain in LCD in comparison to ASIR-V 0%. In addition, the outcomes of the NPS and TTF metrics led to results that would contradict the outcomes of CHO model observers if used for a NPWE model observer (Non- Prewhitening With Eye filter). The unit investigated provides major advantages for cardiac diagnosis without impairing the image quality level of standard chest or abdominal acquisitions.

  18. Structure in defocused beams of x-ray mirrors: causes and possible solutions

    Science.gov (United States)

    Sutter, John P.; Alcock, Simon G.; Rust, Fiona; Wang, Hongchang; Sawhney, Kawal

    2014-09-01

    Grazing incidence mirrors are now a standard optic for focusing X-ray beams. Both bimorph and mechanically bendable mirrors are widely used at Diamond Light Source because they permit a wide choice of focal lengths. They can also be deliberately set out of focus to enlarge the X-ray beam, and indeed many beamline teams now wish to generate uniform beam spots of variable size. However, progress has been slowed by the appearance of fine structure in these defocused beams. Measurements showing the relationship between the medium-frequency polishing error and this structure over a variety of beam sizes will be presented. A theoretical model for the simulations of defocused beams from general mirrors will then be developed. Not only the figure error and its first derivative the slope error, but also the second derivative, the curvature error, must be considered. In conclusion, possible ways to reduce the defocused beam structure by varying the actuators' configuration and settings will be discussed.

  19. In situ micro-focused X-ray beam characterization with a lensless camera using a hybrid pixel detector

    Energy Technology Data Exchange (ETDEWEB)

    Kachatkou, Anton, E-mail: anton.kachatkou@manchester.ac.uk [The University of Manchester, Sackville Street Building, Manchester M13 9PL (United Kingdom); Marchal, Julien [Diamond Light Source Ltd, Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom); Silfhout, Roelof van, E-mail: anton.kachatkou@manchester.ac.uk [The University of Manchester, Sackville Street Building, Manchester M13 9PL (United Kingdom)

    2014-02-04

    Position and size measurements of a micro-focused X-ray beam, using an X-ray beam imaging device based on a lensless camera that collects radiation scattered from a thin foil placed in the path of the beam at an oblique angle, are reported. Results of studies on micro-focused X-ray beam diagnostics using an X-ray beam imaging (XBI) instrument based on the idea of recording radiation scattered from a thin foil of a low-Z material with a lensless camera are reported. The XBI instrument captures magnified images of the scattering region within the foil as illuminated by the incident beam. These images contain information about beam size, beam position and beam intensity that is extracted during dedicated signal processing steps. In this work the use of the device with beams for which the beam size is significantly smaller than that of a single detector pixel is explored. The performance of the XBI device equipped with a state-of-the-art hybrid pixel X-ray imaging sensor is analysed. Compared with traditional methods such as slit edge or wire scanners, the XBI micro-focused beam characterization is significantly faster and does not interfere with on-going experiments. The challenges associated with measuring micrometre-sized beams are described and ways of optimizing the resolution of beam position and size measurements of the XBI instrument are discussed.

  20. Beryllium window and acoustic delay line design for x-ray lithography beam lines at the University of Wisconsin Center for X-ray Lithography

    Science.gov (United States)

    Brodsky, E. L.; Hamilton, W.; Wells, G.; Cerrina, F.; Corradini, M.

    1992-01-01

    X-ray lithography systems require sample chambers that can perform exposures in helium gas at atmospheric pressure. The interface between the experimental chamber and the beamline is critical for x-ray lithography and the storage ring. It must allow a high x-ray flux throughput while providing a vacuum barrier so that helium gas does not leak into the beam line and the storage ring. The beam line must also be designed to have protection in the case that a window does fail in order to minimize adverse effects to the ring and other systems. The details of the design for the vacuum system used on beam lines for the Center for X-ray Lithography at the University of Wisconsin Synchrotron Radiation Center 1-GeV electron storage ring are reported. Curved beryllium windows with a 1×5-cm2 aperture and 13 μm thick that have a leak rate less than 10-10 Torr l/s have been successfully used at the experimental chamber beam-line interface. This thin flat beryllium foil is mounted in a curved housing with a wire seal to minimize helium leakage. The window assembly is designed and has been tested to withstand substantial overpressure before failure. If the beryllium window does fail, the beamline has an acoustic delay line that is designed to delay the incoming shock wave of helium gas so that a fast valve at the end of the beam line will close and minimize leakage of helium into the storage ring. The acoustic delay line is designed with baffles to slow the shock front and a secondary thin window to protect against molecular diffusion into the storage ring. The acoustic delay line has been tested to determine the effect of baffle design on delay of the shock wave. A theoretical model that provides a good description of the acoustic delay has also been developed.

  1. Quantitative breast tissue characterization using grating-based x-ray phase-contrast imaging

    Science.gov (United States)

    Willner, M.; Herzen, J.; Grandl, S.; Auweter, S.; Mayr, D.; Hipp, A.; Chabior, M.; Sarapata, A.; Achterhold, K.; Zanette, I.; Weitkamp, T.; Sztrókay, A.; Hellerhoff, K.; Reiser, M.; Pfeiffer, F.

    2014-04-01

    X-ray phase-contrast imaging has received growing interest in recent years due to its high capability in visualizing soft tissue. Breast imaging became the focus of particular attention as it is considered the most promising candidate for a first clinical application of this contrast modality. In this study, we investigate quantitative breast tissue characterization using grating-based phase-contrast computed tomography (CT) at conventional polychromatic x-ray sources. Different breast specimens have been scanned at a laboratory phase-contrast imaging setup and were correlated to histopathology. Ascertained tumor types include phylloides tumor, fibroadenoma and infiltrating lobular carcinoma. Identified tissue types comprising adipose, fibroglandular and tumor tissue have been analyzed in terms of phase-contrast Hounsfield units and are compared to high-quality, high-resolution data obtained with monochromatic synchrotron radiation, as well as calculated values based on tabulated tissue properties. The results give a good impression of the method’s prospects and limitations for potential tumor detection and the associated demands on such a phase-contrast breast CT system. Furthermore, the evaluated quantitative tissue values serve as a reference for simulations and the design of dedicated phantoms for phase-contrast mammography.

  2. Effect of oblique X-ray incidence in flat-panel computed tomography of the breast.

    Science.gov (United States)

    Badano, Aldo; Kyprianou, Iacovos S; Freed, Melanie; Jennings, Robert J; Sempau, Josep

    2009-05-01

    We quantify the variation in resolution due to anisotropy caused by oblique X-ray incidence in indirect flat-panel detectors for computed tomography breast imaging systems. We consider a geometry and detector type utilized in breast computed tomography (CT) systems currently being developed. Our methods rely on mantis, a combined X-ray, electron, and optical Monte Carlo transport open source code. The physics models are the most accurate available in general-purpose Monte Carlo packages in the diagnostic energy range. We consider maximum-obliquity angles of 10 ( degrees ) and 13 ( degrees ) at the centers of the 30 and 40 cm detector edges, respectively, and 16 ( degrees ) at the corner of the detector. Our results indicate that blur is asymmetric and that the resolution properties vary significantly with the angle (or location) of incidence. Our results suggest that the asymmetry can be as high as a factor of 2.6 between orthogonal directions. Anisotropy maps predicted by mantis provide an understanding of the effect that such variations have on the imaging system and allow more accurate modeling and optimization of breast CT systems. These maps of anisotropy across the detector could lead to improved reconstruction and help motivate physics-based strategies for computer detection of breast lesions.

  3. Advanced simulations of x-ray beam propagation through CRL transfocators using ray-tracing and wavefront propagation methods

    DEFF Research Database (Denmark)

    Baltser, Jana; Bergbäck Knudsen, Erik; Vickery, Anette

    2011-01-01

    of X-ray beamline designs for particular user experiments. In this work we used the newly developed McXtrace ray-tracing package and the SRW wave-optics code to simulate the beam propagation of X-ray undulator radiation through such a "transfocator" as implemented at ID- 11 at ESRF. By applying two...

  4. X-rays diffraction on a new chromium oxide single-crystal thin film prepared by molecular beam epitaxy

    NARCIS (Netherlands)

    Du, X. S.; Hak, S.; Hibma, T.; Rogojanu, O. C.; Struth, B.

    2006-01-01

    Chromium oxide films were prepared on MgO substrates by molecular beam epitaxy. The crystalline structure of the films was characterized by X-ray diffraction (XRD) with conventional as well as synchrotron X-ray sources. The theta-2 theta spectra showed that the film was a new chromium oxide epitaxia

  5. Design and advancement status of the Beam Expander Testing X-ray facility (BEaTriX)

    CERN Document Server

    Spiga, D; Salmaso, B; Arcangeli, L; Bianucci, G; Ferrari, C; Ghigo, M; Pareschi, G; Rossi, M; Tagliaferri, G; Valsecchi, G; Vecchi, G; Zappettini, A

    2016-01-01

    The BEaTriX (Beam Expander Testing X-ray facility) project is an X-ray apparatus under construction at INAF/OAB to generate a broad (200 x 60 mm2), uniform and low-divergent X-ray beam within a small lab (6 x 15 m2). BEaTriX will consist of an X-ray source in the focus a grazing incidence paraboloidal mirror to obtain a parallel beam, followed by a crystal monochromation system and by an asymmetrically-cut diffracting crystal to perform the beam expansion to the desired size. Once completed, BEaTriX will be used to directly perform the quality control of focusing modules of large X-ray optics such as those for the ATHENA X-ray observatory, based on either Silicon Pore Optics (baseline) or Slumped Glass Optics (alternative), and will thereby enable a direct quality control of angular resolution and effective area on a number of mirror modules in a short time, in full X-ray illumination and without being affected by the finite distance of the X-ray source. However, since the individual mirror modules for ATHENA...

  6. Subacute neuropathological effects of microplanar beams of x-rays from a synchrotron wiggler.

    Science.gov (United States)

    Slatkin, D N; Spanne, P; Dilmanian, F A; Gebbers, J O; Laissue, J A

    1995-09-12

    Microplanar beam radiation therapy has been proposed to treat brain tumors by using a series of rapid exposures to an array of parallel x-ray beams, each beam having uniform microscopic thickness and macroscopic breadth (i.e., microplanar). Thirty-six rats were exposed head-on either to an upright 4-mm-high, 20- or 37-microns-wide beam or to a horizontal 7-mm-wide, 42-microns-high beam of mostly 32- to 126-keV, minimally divergent x-rays from the X17 wiggler at the National Synchrotron Light Source at Brookhaven National Laboratory. Parallel slices of the head, separated at either 75 or 200 microns on center, were exposed sequentially at 310-650 grays (Gy) per second until each skin-entrance absorbed dose reached 312, 625, 1250, 2500, 5000, or 10,000 Gy. The rats were euthanized 2 weeks or 1 month later. Two rats with 10,000-Gy-entrance slices developed brain tissue necrosis. All the other 10,000- and 5000-Gy-entrance slices and some of the 2500- and 1250-Gy-entrance slices showed loss of neuronal and astrocytic nuclei and their perikarya. No other kind of brain damage was evident histologically in any rat with entrance absorbed doses beam radiation therapy for brain tumors.

  7. High-resolution diffraction microscopy using the plane-wave field of a nearly diffraction limited focused x-ray beam

    OpenAIRE

    Takahashi, Yukio; Nishino, Yoshinori; Tsutsumi, Ryosuke; Kubo, Hideto; Furukawa, Hayato; Mimura, Hidekazu; MATSUYAMA, Satoshi; Zettsu, Nobuyuki; Matsubara, Eiichiro; Ishikawa, Tetsuya; Yamauchi, Kazuto

    2009-01-01

    X-ray waves in the center of the beam waist of nearly diffraction limited focused x-ray beams can be considered to have amplitude and phase that are both almost uniform, i.e., they are x-ray plane waves. Here we report the results of an experimental demonstration of high-resolution diffraction microscopy using the x-ray plane wave of the synchrotron x-ray beam focused using Kirkpatrik-Baez mirrors. A silver nanocube with an edge length of ∼100 nm is illuminated with the x-ray beam focused to ...

  8. Ray-tracing simulations of spherical Johann diffraction spectrometer for in-beam X-ray experiments

    Energy Technology Data Exchange (ETDEWEB)

    Jagodziński, P., E-mail: jagodzin@tu.kielce.pl [Department of Physics, Kielce University of Technology, Tysiaclecia PP 7, 25-314 Kielce (Poland); Pajek, M.; Banaś, D. [Institute of Physics, Jan Kochanowski University, Świȩtokrzyska 15, 25-406 Kielce (Poland); Beyer, H.F. [GSI Helmholtzzentrum für Schwerionenforschung, D-64291 Darmstadt (Germany); Trassinelli, M. [Institut des NanoSciences de Paris, Université Pierre et Marie Curie, 4 Place Jussieu, 75015 Paris (France); Stoehlker, Th. [GSI Helmholtzzentrum für Schwerionenforschung, D-64291 Darmstadt (Germany); Helmholtz-Insitut Jena, D-07743 Jena (Germany); Institut für Optic und Quantenelektronik, Friedrich-Schiller-Universität Jena, D-07743 Jena (Germany)

    2014-07-01

    The results of the Monte-Carlo ray-tracing simulations for a Johann-type Bragg spectrometer with spherically curved-crystal designed to detect the X-rays from a fast-moving source are reported. These calculations were performed to optimize the X-ray spectrometer to be used at the gas-target installed at ion storage ring for high-resolution X-ray experiments. In particular, the two-dimensional distributions of detected photons were studied using the Monte-Carlo method both for the stationary and moving X-ray sources, taking into account a detailed description of X-ray source and X-ray diffraction on the crystal as well as a role of the Doppler effect for in-beam experiments. The origin of the asymmetry of observed X-ray profiles was discussed in detail and the procedure to derive a precise (sub-eV) X-ray transition energy for such asymmetric profiles was proposed. The results are important for the investigations of 1s2p{sup 3}P{sub 2}→1s2s{sup 3}S{sub 1} intrashell transition in excited He-like uranium ions in in-beam X-ray experiments.

  9. Soft X-Ray Magnetic Imaging of Focused Ion Beam Lithographically Patterned Fe Thin Films

    Energy Technology Data Exchange (ETDEWEB)

    Cook, Paul J.; Shen, Tichan H.; Grundy, PhilJ.; Im, Mi Young; Fischer, Peter; Morton, Simon A.; Kilcoyne, Arthur D.L.

    2008-11-09

    We illustrate the potential of modifying the magnetic behavior and structural properties of ferromagnetic thin films using focused ion beam 'direct-write' lithography. Patterns inspired by the split-ring resonators often used as components in meta-materials were defined upon 15 nm Fe films using a 30 keV Ga{sup +} focused ion beam at a dose of 2 x 10{sup 16} ions cm{sup -2}. Structural, chemical and magnetic changes to the Fe were studied using transmission soft X-ray microscopy at the ALS, Berkeley CA. X-ray absorption spectra showed a 23% reduction in the thickness of the film in the Ga irradiated areas, but no change to the chemical environment of Fe was evident. X-ray images of the magnetic reversal process show domain wall pinning around the implanted areas, resulting in an overall increase in the coercivity of the film. Transmission electron microscopy showed significant grain growth in the implanted regions.

  10. Fast and thermal neutron profiles for a 25-MV x-ray beam.

    Science.gov (United States)

    Price, K W; Nath, R; Holeman, G R

    1978-01-01

    High-energy x-ray radiotherapy machines generate neutrons by photonuclear reactions in the target and the treatment head and expose the patient to a neutron flux. In order to evaluate the neutron exposure quantitatively, fast and thermal neutron profiles for 25-MV x-ray beams of the Sagittaire accelerator have been measured. An activation technique, using the reactions 31P(n, gamma)32P (thermal neutrons) and 31P(n, p)31Si (fast neutrons, E greater than 0.7 MeV), has been developed to measure fast- and thermal-neutron fluxes in an intense high-energy photon flux. The sensitivity of this activation detector to high-energy photons, which has plagued many previous neutron measurements, was carefully measured and found to be less than 4%. Neutron fluxes for various photon field sizes ranging from 5 X 5 cm to 30 X 30 cm have been measured. The fast-neutron profiles were observed to have rounded edges and the thermal fluxes were found to be relatively uniform. In the central part of the x-ray beam, the ratio of neutron dose equivalent to photon absorbed dose was found to be between 0.2% and 0.5%. Outside of the photon field, the ratio of neutron dose equivalent to the central-axis photon absorbed dose was 0.12%.

  11. Electron Beam Production and Characterization for the PLEIADES Thomson X-ray Source

    Energy Technology Data Exchange (ETDEWEB)

    Brown, W J; Hartemann, F V; Tremaine, A M; Springer, P T; Le Sage, G P; Barty, C P J; Rosenzweig, J B; Crane, J K; Cross, R R; Fittinghoff, D B; Gibson, D J; Slaughter, D R; Anderson, S

    2002-10-14

    We report on the performance of an S-band RF photocathode electron gun and accelerator for operation with the PLEIADES Thomson x-ray source at LLNL. Simulations of beam production, transport, and focus are presented. It is shown that a 1 ps, 500 pC electron bunch with a normalized emittance of less than 5 {pi}mm-mrad can be delivered to the interaction point. Initial electron measurements are presented. Calculations of expected x-ray flux are also performed, demonstrating an expected peak spectral brightness of 10{sup 20} photons/s/mm{sup 2}/mrad{sup 2}/0.1% bandwidth. Effects of RF phase jitter are also presented, and planned phase measurements and control methods are discussed.

  12. X-ray micro-beam characterization of a small pixel spectroscopic CdTe detector

    Science.gov (United States)

    Veale, M. C.; Bell, S. J.; Seller, P.; Wilson, M. D.; Kachkanov, V.

    2012-07-01

    A small pixel, spectroscopic, CdTe detector has been developed at the Rutherford Appleton Laboratory (RAL) for X-ray imaging applications. The detector consists of 80 × 80 pixels on a 250 μm pitch with 50 μm inter-pixel spacing. Measurements with an 241Am γ-source demonstrated that 96% of all pixels have a FWHM of better than 1 keV while the majority of the remaining pixels have FWHM of less than 4 keV. Using the Diamond Light Source synchrotron, a 10 μm collimated beam of monochromatic 20 keV X-rays has been used to map the spatial variation in the detector response and the effects of charge sharing corrections on detector efficiency and resolution. The mapping measurements revealed the presence of inclusions in the detector and quantified their effect on the spectroscopic resolution of pixels.

  13. Investigation of GEM-Micromegas Detector on X-ray Beam of Synchrotron Radiation

    CERN Document Server

    Zhang, YuLian; Hu, BiTao; Fan, ShengNan; Wang, Bo; Liu, Mei; Zhang, Jian; Liu, RongGuang; Chang, GuangCai; Liu, Peng; Ouyang, Qun; Chen, YuanBo; Yi, FuTing

    2013-01-01

    To solve the discharge of the standard Bulk Micromegas and GEM detector, the GEM-Micromegas detector was developed in Institute of High Energy Physics. Taking into account the advantages of the two detectors, one GEM foil was set as a preamplifier on the mesh of Micromegas in the structure and the GEM preamplification decreased the working voltage of Micromegas to reduce the effect of the discharge significantly. In the paper, the performance of detector in X-ray beam was studied at 1W2B laboratory of Beijing Synchrotron Radiation Facility. Finally, the result of the energy resolution under various X-ray energies was given in different working gases. It indicated that the GEM-Micromegas detector had the energy response capability in all the energy range and it could work better than the standard Bulk-Micromegas.

  14. BEaTriX, expanded X-ray beam facility for testing modular elements of telescope optics: an update

    CERN Document Server

    Pelliciari, Carlo; Bonnini, Elisa; Buffagni, Elisa; Ferrari, Claudio; Pareschi, Giovanni; Tagliaferri, Gianpiero

    2016-01-01

    We present in this paper an update on the design of BEaTriX (Beam Expander Testing X-ray facility), an X-ray apparatus to be realized at INAF/OAB and that will generate an expanded, uniform and parallel beam of soft X-rays. BEaTriX will be used to perform the functional tests of X-ray focusing modules of large X-ray optics such as those for the ATHENA X-ray observatory, using the Silicon Pore Optics (SPO) as a baseline technology, and Slumped Glass Optics (SGO) as a possible alternative. Performing the tests in X-rays provides the advantage of an in-situ, at-wavelength quality control of the optical modules produced in series by the industry, performing a selection of the modules with the best angular resolution, and, in the case of SPOs, there is also the interesting possibility to align the parabolic and the hyperbolic stacks directly under X-rays, to minimize the aberrations. However, a parallel beam with divergence below 2 arcsec is necessary in order to measure mirror elements that are expected to reach ...

  15. Design of x-ray diagnostic beam line for a synchrotron radiation source and measurement results

    Science.gov (United States)

    Garg, Akash Deep; Karnewar, A. K.; Ojha, A.; Shrivastava, B. B.; Holikatti, A. C.; Puntambekar, T. A.; Navathe, C. P.

    2014-08-01

    Indus-2 is a 2.5 GeV synchrotron radiation source (SRS) operational at the Raja Ramanna Centre for Advanced Technology (RRCAT) in India. We have designed, developed and commissioned x-ray diagnostic beam line (X-DBL) at the Indus-2. It is based on pinhole array imaging (8-18 keV). We have derived new equations for online measurements of source position and emission angle with pinhole array optics. Measured values are compared with the measurements at an independent x-ray beam position monitor (staggered pair blade monitor) installed in the X-DBL. The measured values are close to the theoretical expected values within ±12 μm (or ±1.5 μrad) for sufficiently wide range of the beam movements. So, beside the beam size and the beam emittance, online information for the vertical position and angle is also used in the orbit steering. In this paper, the various design considerations of the X-DBL and online measurement results are presented.

  16. Electron-Excited X-Ray Microanalysis at Low Beam Energy: Almost Always an Adventure!

    Science.gov (United States)

    Newbury, Dale E; Ritchie, Nicholas W M

    2016-08-01

    Scanning electron microscopy with energy-dispersive spectrometry has been applied to the analysis of various materials at low-incident beam energies, E 0≤5 keV, using peak fitting and following the measured standards/matrix corrections protocol embedded in the National Institute of Standards and Technology Desktop Spectrum Analyzer-II analytical software engine. Low beam energy analysis provides improved spatial resolution laterally and in-depth. The lower beam energy restricts the atomic shells that can be ionized, reducing the number of X-ray peak families available to the analyst. At E 0=5 keV, all elements of the periodic table except H and He can be measured. As the beam energy is reduced below 5 keV, elements become inaccessible due to lack of excitation of useful characteristic X-ray peaks. The shallow sampling depth of low beam energy microanalysis makes the technique more sensitive to surface compositional modification due to formation of oxides and other reaction layers. Accurate and precise analysis is possible with the use of appropriate standards and by accumulating high count spectra of unknowns and standards (>1 million counts integrated from 0.1 keV to E 0).

  17. Fluorescence-based knife-edge beam diameter measurement to characterize X-ray beam profiles in reflection geometry

    Science.gov (United States)

    Bassel, Léna; Tauzin, Xavier; Queffelec, Alain; Ferrier, Catherine; Lacanette, Delphine; Chapoulie, Rémy; Bousquet, Bruno

    2016-04-01

    The diameter of an X-ray beam was determined, using the knife-edge technique, widely applied for beam profiling, by taking advantage of the fluorescence emission generated by the X-ray beam. The knife-edge has to be appropriate to the configuration of the device, in our case a double-material target made of plastic and cardboard was scanned in a transversal plane compared to the beam propagation direction. Along the scanning axis, for each position, the intensity of the Kα line of chlorine was recorded. The first derivative of the intensity evolution as a function of the edge position, fitted by a Gaussian function, makes it possible to obtain the beam diameter along the scan direction. We measured a slightly elliptic diameter close to 3 mm. In this note we underline the significance of the knife-edge technique which represents a useful tool, easy to be set up, to control X-ray beam dimensions in portable devices often routinely used by non-specialists.

  18. Investigating the effect of characteristic x-rays in cadmium zinc telluride detectors under breast computerized tomography operating conditions.

    Science.gov (United States)

    Glick, Stephen J; Didier, Clay

    2013-10-14

    A number of research groups have been investigating the use of dedicated breast computerized tomography (CT). Preliminary results have been encouraging, suggesting an improved visualization of masses on breast CT as compared to conventional mammography. Nonetheless, there are many challenges to overcome before breast CT can become a routine clinical reality. One potential improvement over current breast CT prototypes would be the use of photon counting detectors with cadmium zinc telluride (CZT) (or CdTe) semiconductor material. These detectors can operate at room temperature and provide high detection efficiency and the capability of multi-energy imaging; however, one factor in particular that limits image quality is the emission of characteristic x-rays. In this study, the degradative effects of characteristic x-rays are examined when using a CZT detector under breast CT operating conditions. Monte Carlo simulation software was used to evaluate the effect of characteristic x-rays and the detector element size on spatial and spectral resolution for a CZT detector used under breast CT operating conditions. In particular, lower kVp spectra and thinner CZT thicknesses were studied than that typically used with CZT based conventional CT detectors. In addition, the effect of characteristic x-rays on the accuracy of material decomposition in spectral CT imaging was explored. It was observed that when imaging with 50-60 kVp spectra, the x-ray transmission through CZT was very low for all detector thicknesses studied (0.5-3.0 mm), thus retaining dose efficiency. As expected, characteristic x-ray escape from the detector element of x-ray interaction increased with decreasing detector element size, approaching a 50% escape fraction for a 100 μm size detector element. The detector point spread function was observed to have only minor degradation with detector element size greater than 200 μm and lower kV settings. Characteristic x-rays produced increasing distortion

  19. Coherence properties of focused X-ray beams at high brilliance synchrotron sources

    CERN Document Server

    Singer, A

    2013-01-01

    An analytical approach describing properties of focused partially coherent X-ray beams is presented. The method is based on the results of statistical optics and gives both the beam size and transverse coherence length at any distance behind an optical element. In particular, here we consider Gaussian Schell-model beams and thin optical elements. Limiting cases of incoherent and fully coherent illumination of the focusing element are discussed. The effect of the beam defining aperture, typically used in combination with focusing elements at synchrotron sources to improve transverse coherence, is also analyzed in detail. As an example the coherence properties in the focal region of compound refractive lenses at the PETRA III synchrotron source are analyzed.

  20. Radiological characterization and water equivalency of genipin gel for x-ray and electron beam dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Gorjiara, Tina; Hill, Robin; Kuncic, Zdenka; Bosi, Stephen; Davies, Justin B; Baldock, Clive, E-mail: clive.baldock@sydney.edu.au [Institute of Medical Physics, School of Physics, University of Sydney, NSW 2006 (Australia)

    2011-08-07

    The genipin radiochromic gel offers enormous potential as a three-dimensional dosimeter in advanced radiotherapy techniques. We have used several methods (including Monte Carlo simulation), to investigate the water equivalency of genipin gel by characterizing its radiological properties, including mass and electron densities, photon interaction cross sections, mass energy absorption coefficient, effective atomic number, collisional, radiative and total mass stopping powers and electron mass scattering power. Depth doses were also calculated for clinical kilovoltage and megavoltage x-ray beams as well as megavoltage electron beams. The mass density, electron density and effective atomic number of genipin were found to differ from water by less than 2%. For energies below 150 keV, photoelectric absorption cross sections are more than 3% higher than water due to the strong dependence on atomic number. Compton scattering and pair production interaction cross sections for genipin gel differ from water by less than 1%. The mass energy absorption coefficient is approximately 3% higher than water for energies <60 keV due to the dominance of photoelectric absorption in this energy range. The electron mass stopping power and mass scattering power differ from water by approximately 0.3%. X-ray depth dose curves for genipin gel agree to within 1% with those for water. Our results demonstrate that genipin gel can be considered water equivalent for kilovoltage and megavoltage x-ray beam dosimetry. For megavoltage electron beam dosimetry, however, our results suggest that a correction factor may be needed to convert measured dose in genipin gel to that of water, since differences in some radiological properties of up to 3% compared to water are observed. Our results indicate that genipin gel exhibits greater water equivalency than polymer gels and PRESAGE formulations.

  1. Beam hardening: analytical considerations of the effective attenuation coefficient of X-ray tomography.

    Science.gov (United States)

    Alles, J; Mudde, R F

    2007-07-01

    Polychromatic x-ray beams traveling though material are prone to beam hardening, i.e., the high energy part of the incident spectrum gets over represented when traveling farther into the material. This study discusses the concept of a mean attenuation coefficient in a formal way. The total energy fluence is one-to-one related to the traveled distance in case of a polychromatic beam moving through a given, inhomogeneous material. On the basis of this one-to-one relation, it is useful to define a mean attenuation coefficient and study its decrease with depth. Our results are based on a novel parametrization of the energy dependence of the attenuation coefficient that allows for closed form evaluation of certain spectral integrals. This approach underpins the ad hoc semianalytical expressions given in the literature. An analytical model for the average attenuation coefficient is proposed that uses a simple fit of the attenuation coefficient as a function of the photon energy as input. It is shown that a simple extension of this model gives a rather good description of beam hardening for x-rays traveling through water.

  2. Scattered hard X-ray and γ-ray generation from a chromatic electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, J. E. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Welch, D. R.; Miller, C. L. [Voss Scientific, Albuquerque, New Mexico 87108 (United States)

    2015-11-14

    An array of photon diagnostics has been deployed on a high power relativistic electron beam diode. Electrons are extracted through a 17.8 cm diode from the surface discharge of a carbon fiber velvet cathode with a nominal diode voltage of 3.8 MV. <10% of the 100 ns electron pulse is composed of off energy electrons (1–3 MeV) accelerated during the rise and fall of the pulse that impact the stainless steel beam pipe and generate a Bremsstrahlung spectrum of 0.1–3 MeV photons with a total count of 10{sup 11}. The principal objective of these experiments is to quantify the electron beam dynamics and spatial dynamics of the hard X-ray and γ-ray flux generated in the diode region. A qualitative comparison of experimental and calculated results are presented, including time and energy resolved electron beam propagation and scattered photon measurements with X-ray PIN diodes and a photomultiplier tube indicating a dose dependence on the diode voltage >V{sup 4} and detected photon counts of nearly 10{sup 6} at a radial distance of 1 m which corresponds to dose ∼40 μrad at 1 m.

  3. Thermometric- and Acoustic-Based Beam Power Monitor for Ultra-Bright X-Rays

    Energy Technology Data Exchange (ETDEWEB)

    Bentsen, Gregory; /Rochester U. /SLAC

    2010-08-25

    A design for an average beam power monitor for ultra-bright X-ray sources is proposed that makes simultaneous use of calorimetry and radiation acoustics. Radiation incident on a solid target will induce heating and ultrasonic vibrations, both of which may be measured to give a fairly precise value of the beam power. The monitor is intended for measuring ultra-bright Free-Electron Laser (FEL) X-ray beams, for which traditional monitoring technologies such as photo-diodes or scintillators are unsuitable. The monitor consists of a Boron Carbide (B{sub 4}C) target designed to absorb most of the incident beam's energy. Resistance temperature detectors (RTD) and piezoelectric actuators are mounted on the outward faces of the target to measure the temperature changes and ultrasonic vibrations induced by the incident beam. The design was tested using an optical pulsed beam (780 nm, 120 and 360 Hz) from a Ti:sapphire oscillator at several energies between 0.8 and 2.6 mJ. The RTDs measured an increase in temperature of about 10 K over a period of several minutes. The piezoelectric sensors recorded ringing acoustic oscillations at 580 {+-} 40 kHz. Most importantly, the amplitude of the acoustic signals was observed to scale linearly with beam power up to 2 mJ of pulse energy. Above this pulse energy, the vibrational signals became nonlinear. Several causes for this nonlinearity are discussed, including amplifier saturation and piezoelectric saturation. Despite this nonlinearity, these measurements demonstrate the feasibility of such a beam power measurement device. The advantage of two distinct measurements (acoustic and thermometric) provides a useful method of calibration that is unavailable to current LCLS diagnostics tools.

  4. Development of Kilovoltage X-ray Dosimetry Methods and Their Application to Cone Beam Computed Tomography

    Science.gov (United States)

    Lawless, Michael J.

    The increase in popularity of pre-treatment imaging procedures in radiation therapy, such as kilovoltage cone beam computed tomography (CBCT), has been accompanied by an increase in the dose delivered to the patient from these imaging procedures. The measurement of dose from CBCT scans is complicated, as currently available kilovoltage dosimetry protocols are based on air-kerma standards and radiation detectors exhibit large energy responses at the low photon energies used in the imaging procedures. This work aims to provide the tools and methodology needed to measure the dose from these scans more accurately and precisely. Through the use of a validated Monte Carlo (MC) model of the moderately filtered (M-series) x-ray beams at the University of Wisconsin Accredited Dosimetry Calibration Laboratory, dose-to-water rates were obtained in a water phantom for the M-series x-ray beams with tube potentials from 40-250 kVp. The resulting dose-to-water rates were consistent with previously established methods, but had significantly reduced uncertainties. While detectors are commonly used to measure dose in phantom, previous investigations of the energy response of common detectors in the kilovoltage energy range have been limited to in-air geometries. The newly determined dose-to-water rates were used to characterize the in-phantom energy and depth response of thermoluminescent dosimeters and ionization chambers. When compared to previous investigations of the in-air detector response, the impact of scatter and absorption of the photon beam by the water medium was found to have a significant impact on the response of certain detectors. The dose to water in the NIST-traceable M-series x-ray beams was transferred to clinical CBCT beams and the resulting doses agreed with other dose-to-water measurement techniques. The dose to water in the CBCT beams was used to characterize the energy and depth responses of a number of detectors. The energy response in the CBCT beams agreed

  5. 3D Medipix2 detector characterization with a micro-focused X-ray beam

    Science.gov (United States)

    Gimenez, E. N.; Maneuski, D.; Mac Raighne, A.; Parkes, C.; Bates, R.; O'Shea, V.; Fleta, C.; Pellegrini, G.; Lozano, M.; Alianelli, L.; Sawhney, K. J. S.; Marchal, J.; Tartoni, N.

    2011-05-01

    Three-dimensional (3D) photodiode detectors offer advantages over standard planar photodiodes in a wide range of applications. The main advantage of these sensors for X-ray imaging is their reduced charge sharing between adjacent pixels, which could improve spatial and spectral resolution. However, a drawback of 3D sensors structures is the loss of detection efficiency due to the presence in the pixel structure of heavily doped electrode columns which are insensitive to X-ray. In this work two types of 3D silicon detectors: n-type wafer with hole collecting readout-columns (N-TYPE) and p-type wafer with electron collecting readout-columns (P-TYPE), bump-bounded to a Medipix2 read-out chip were characterized with a 14.5 keV micro-focused X-ray beam from a synchrotron. Measurements of the detection efficiency and the charge sharing were performed at different bias voltages and Medipix2 energy thresholds and compared with those of a standard planar silicon sensor.

  6. Semi-empirical model for fluorescence lines evaluation in diagnostic x-ray beams.

    Science.gov (United States)

    Bontempi, Marco; Andreani, Lucia; Labanti, Claudio; Costa, Paulo Roberto; Rossi, Pier Luca; Baldazzi, Giuseppe

    2016-01-01

    Diagnostic x-ray beams are composed of bremsstrahlung and discrete fluorescence lines. The aim of this study is the development of an efficient model for the evaluation of the fluorescence lines. The most important electron ionization models are analyzed and implemented. The model results were compared with experimental data and with other independent spectra presented in the literature. The implemented peak models allow the discrimination between direct and indirect radiation emitted from tungsten anodes. The comparison with the independent literature spectra indicated a good agreement.

  7. A portable molecular beam epitaxy system for in situ x-ray investigations at synchrotron beamlines.

    Science.gov (United States)

    Slobodskyy, T; Schroth, P; Grigoriev, D; Minkevich, A A; Hu, D Z; Schaadt, D M; Baumbach, T

    2012-10-01

    A portable synchrotron molecular beam epitaxy (MBE) system is designed and applied for in situ investigations. The growth chamber is equipped with all the standard MBE components such as effusion cells with shutters, main shutter, cooling shroud, manipulator, reflection high energy electron diffraction setup, and pressure gauges. The characteristic feature of the system is the beryllium windows which are used for in situ x-ray measurements. An UHV sample transfer case allows in vacuo transfer of samples prepared elsewhere. We describe the system design and demonstrate its performance by investigating the annealing process of buried InGaAs self-organized quantum dots.

  8. Attempt at Visualizing Breast Cancer with X-ray Dark Field Imaging

    Science.gov (United States)

    Ando, Masami; Yamasaki, Katsuhito; Toyofuku, Fukai; Sugiyama, Hiroshi; Ohbayashi, Chiho; Li, Gang; Pan, Lin; Jiang, Xiaoming; Pattanasiriwisawa, Wanwisa; Shimao, Daisuke; Hashimoto, Eiko; Kimura, Tatsuro; Tsuneyoshi, Masazumi; Ueno, Ei; Tokumori, Kenji; Maksimenko, Anton; Higashida, Yoshiharu; Hirano, Masatsugu

    2005-04-01

    X-ray dark-field imaging (DFI) can clearly visualize breast cancer phantoms and cancer cell nests, stroma, fat tissue, ductus lactiferi, muscle, collagen fibers at stroma and calcification in a 2.8-mm-thick breast cancer pathological specimen. The system comprises a Bragg asymmetric-cut monochro-collimator and a 2.124-mm-thick Si 440 Laue diffraction analyzer at 35 keV. Both optical elements are Floating Zone made silicon crystals. The view size of 33 mm (H) × 19.5 mm (V) and the spatial resolution of 10 μm or better are obtainable at the vertical wiggler beamline BL14B at the Photon Factory.

  9. X-ray interferometry with transmissive beam combiners for ultra-high angular resolution astronomy

    CERN Document Server

    Skinner, G K; 10.1007/s10686-009-9175-4

    2009-01-01

    Interferometry provides one of the possible routes to ultra-high angular resolution for X-ray and gamma-ray astronomy. Sub-micro-arc-second angular resolution, necessary to achieve objectives such as imaging the regions around the event horizon of a super-massive black hole at the center of an active galaxy, can be achieved if beams from parts of the incoming wavefront separated by 100s of meters can be stably and accurately brought together at small angles. One way of achieving this is by using grazing incidence mirrors. We here investigate an alternative approach in which the beams are recombined by optical elements working in transmission. It is shown that the use of diffractive elements is a particularly attractive option. We report experimental results from a simple 2-beam interferometer using a low-cost commercially available profiled film as the diffractive elements. A rotationally symmetric filled (or mostly filled) aperture variant of such an interferometer, equivalent to an X-ray axicon, is shown to...

  10. Pulse-periodic generation of supershort avalanche electron beams and X-ray emission

    Science.gov (United States)

    Baksht, E. Kh.; Burachenko, A. G.; Erofeev, M. V.; Tarasenko, V. F.

    2014-05-01

    Pulse-periodic generation of supershort avalanche electron beams (SAEBs) and X-ray emission in nitrogen, as well as the transition from a single-pulse mode to a pulse-periodic mode with a high repetition frequency, was studied experimentally. It is shown that, in the pulse-periodic mode, the full width at halfmaximum of the SAEB is larger and the decrease rate of the gap voltage is lower than those in the single-pulse mode. It is found that, when the front duration of the voltage pulse at a nitrogen pressure of 90 Torr decreases from 2.5 to 0.3 ns, the X-ray exposure dose in the pulse-periodic mode increases by more than one order of magnitude and the number of SAEB electrons also increases. It is shown that, in the pulse-periodic mode of a diffuse discharge, gas heating in the discharge gap results in a severalfold increase in the SAEB amplitude (the number of electrons in the beam). At a generator voltage of 25 kV, nitrogen pressure of 90 Torr, and pulse repetition frequency of 3.5 kHz, a runaway electron beam was detected behind the anode foil.

  11. X-ray Interferometry with Transmissive Beam Combiners for Ultra-High Angular Resolution Astronomy

    Science.gov (United States)

    Skinner, G. K.; Krismanic, John F.

    2009-01-01

    Abstract Interferometry provides one of the possible routes to ultra-high angular resolution for X-ray and gamma-ray astronomy. Sub-micro-arc-second angular resolution, necessary to achieve objectives such as imaging the regions around the event horizon of a super-massive black hole at the center of an active galaxy, can be achieved if beams from parts of the incoming wavefront separated by 100s of meters can be stably and accurately brought together at small angles. One way of achieving this is by using grazing incidence mirrors. We here investigate an alternative approach in which the beams are recombined by optical elements working in transmission. It is shown that the use of diffractive elements is a particularly attractive option. We report experimental results from a simple 2-beam interferometer using a low-cost commercially available profiled film as the diffractive elements. A rotationally symmetric filled (or mostly filled) aperture variant of such an interferometer, equivalent to an X-ray axicon, is shown to offer a much wider bandpass than either a Phase Fresnel Lens (PFL) or a PFL with a refractive lens in an achromatic pair. Simulations of an example system are presented.

  12. Thermoluminescent response of CaSO{sub 4}:Dy+PTFE induced by X-ray beams

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez, L. [Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada-Legaria, IPN. Av. Legaria 694 C.P. 11500 Mexico D.F. (Mexico); Rivera, T., E-mail: trivera@ipn.mx [Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada-Legaria, IPN. Av. Legaria 694 C.P. 11500 Mexico D.F. (Mexico); Jimenez, Y.; Alvarez, R.; Zeferino, J.; Vazquez, A. [Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada-Legaria, IPN. Av. Legaria 694 C.P. 11500 Mexico D.F. (Mexico); Azorin, J. [Universidad Autonoma Metropolitana-Iztapalapa. Av. San Rafael Atlixco 186, C.P. 09340 Mexico D.F. (Mexico)

    2012-07-15

    The aim of the present work was to evaluate the feasibility of the utilization of CaSO{sub 4}:Dy pellets for X-ray measurements in a general radiology department. Thermoluminescence (TL) response of CaSO{sub 4}:Dy+PTFE was compared to the TL response of commercial LiF:Mg,Ti (TLD-100) samples. TL pellets were exposed to X-ray beam from X-ray machine CMR for clinical diagnosis purpose. The calibration curve of CaSO{sub 4}:Dy+PTFE was obtained and it showed a linear response as a function of absorbed dose in air at the studied dose interval. Despite this fact, this material can be used for X-ray beams measurements if appropriate calibration procedures are performed. - Highlights: Black-Right-Pointing-Pointer Developing of CaSO{sub 4}:Dy to quasimono-energetic X-ray low energy dosimetry. Black-Right-Pointing-Pointer Thermoluminescent response of caSO{sub 4}:Dy to X-ray low dose. Black-Right-Pointing-Pointer TL characteristics of CaSO{sub 4}:Dy for X-ray beam quality control.

  13. Supershort avalanche electron beams and x-ray in high-pressure nanosecond discharges

    Science.gov (United States)

    Tarasenko, V. F.; Baksht, E. H.; Kostyrya, I. D.; Lomaev, M. I.; Rybka, D. V.

    2008-10-01

    The properties of a supershort avalanche electron beam (S AEB) and X-ray radiation produced using a nanosecond volume discharge are examined. An electron beam of the runaway electrons with amplitude of ~ 50 A has been obtained in air atmospheric pressure. It is reported that S AEB is formed in the angle above 2π sr. Three groups of the runaway electrons are formed in a gas diode under atmospheric air pressure, when nanosecond voltage pulses with amplitude of hundreds of kilovolts are applied. The electron beam has been generated behind a 45 μm thick AlBe foil in SF6 and Xe under the pressure of 2 arm, and in He under the pressure of about 12 atm. The paper gives the analysis of a generation mechanism of SAEB.

  14. Advanced in situ metrology for x-ray beam shaping with super precision.

    Science.gov (United States)

    Wang, Hongchang; Sutter, John; Sawhney, Kawal

    2015-01-26

    We report a novel method for in situ metrology of an X-ray bimorph mirror by using the speckle scanning technique. Both the focusing beam and the "tophat" defocussed beam have been generated by optimizing the bimorph mirror in a single iteration. Importantly, we have demonstrated that the angular sensitivity for measuring the slope error of an optical surface can reach accuracy in the range of two nanoradians. When compared with conventional ex-situ metrology techniques, the method enables a substantial increase of around two orders of magnitude in the angular sensitivity and opens the way to a previously inaccessible region of slope error measurement. Such a super precision metrology technique will be beneficial for both the manufacture of polished mirrors and the optimization of beam shaping.

  15. A one-dimensional ion beam figuring system for x-ray mirror fabrication.

    Science.gov (United States)

    Idir, Mourad; Huang, Lei; Bouet, Nathalie; Kaznatcheev, Konstantine; Vescovi, Matthew; Lauer, Ken; Conley, Ray; Rennie, Kent; Kahn, Jim; Nethery, Richard; Zhou, Lin

    2015-10-01

    We report on the development of a one-dimensional Ion Beam Figuring (IBF) system for x-ray mirror polishing. Ion beam figuring provides a highly deterministic method for the final precision figuring of optical components with advantages over conventional methods. The system is based on a state of the art sputtering deposition system outfitted with a gridded radio frequency inductive coupled plasma ion beam source equipped with ion optics and dedicated slit developed specifically for this application. The production of an IBF system able to produce an elongated removal function rather than circular is presented in this paper, where we describe in detail the technical aspect and present the first obtained results.

  16. A one-dimensional ion beam figuring system for x-ray mirror fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Idir, Mourad; Huang, Lei; Bouet, Nathalie; Kaznatcheev, Konstantine; Vescovi, Matthew; Lauer, Ken; Conley, Ray; Rennie, Kent; Kahn, Jim; Nethery, Richard; Zhou, Lin

    2015-10-01

    We report on the development of a one-dimensional Ion Beam Figuring (IBF) system for x-ray mirror polishing. Ion beam figuring provides a highly deterministic method for the final precision figuring of optical components with advantages over conventional methods. The system is based on a state of the art sputtering deposition system outfitted with a gridded radio frequency inductive coupled plasma ion beam source equipped with ion optics and dedicated slit developed specifically for this application. The production of an IBF system able to produce an elongated removal function rather than circular is presented in this paper, where we describe in detail the technical aspect and present the first obtained results. (C) 2015 AIP Publishing LLC.

  17. A one-dimensional ion beam figuring system for x-ray mirror fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Idir, Mourad, E-mail: midir@bnl.gov; Huang, Lei; Bouet, Nathalie; Kaznatcheev, Konstantine; Vescovi, Matthew; Lauer, Ken [NSLS-II, Brookhaven National Laboratory, P.O. Box 5000, Upton, New York 11973 (United States); Conley, Ray [Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439 (United States); Rennie, Kent; Kahn, Jim; Nethery, Richard [Kaufman & Robinson, Inc., 1330 Blue Spruce Drive, Fort Collins, Colorado 80524 (United States); Zhou, Lin [College of Mechatronics and Automation, National University of Defense Technology, 109 Deya Road, Changsha, Hunan 410073 (China); Hu’nan Key Laboratory of Ultra-precision Machining Technology, Changsha, Hunan 410073 (China)

    2015-10-15

    We report on the development of a one-dimensional Ion Beam Figuring (IBF) system for x-ray mirror polishing. Ion beam figuring provides a highly deterministic method for the final precision figuring of optical components with advantages over conventional methods. The system is based on a state of the art sputtering deposition system outfitted with a gridded radio frequency inductive coupled plasma ion beam source equipped with ion optics and dedicated slit developed specifically for this application. The production of an IBF system able to produce an elongated removal function rather than circular is presented in this paper, where we describe in detail the technical aspect and present the first obtained results.

  18. The VANILLA sensor as a beam monitoring device for X-ray radiation therapy.

    Science.gov (United States)

    Velthuis, J J; Hugtenburg, R P; Cussans, D; Perry, M; Hall, C; Stevens, P; Lawrence, H; McKenzie, A

    2014-01-01

    Cancer treatments such as intensity-modulated radiotherapy (IMRT) require increasingly complex methods to verify the accuracy and precision of the treatment delivery. In vivo dosimetry based on measurements made in an electronic portal imaging device (EPID) has been demonstrated. The distorting effect of the patient anatomy on the beam intensity means it is difficult to separate changes in patient anatomy from changes in the beam intensity profile. Alternatively, upstream detectors scatter and attenuate the beam, changing the energy spectrum of the beam, and generate contaminant radiation such as electrons. We used the VANILLA device, a Monolithic Active Pixel Sensor (MAPS), to measure the 2D beam profile of a 6 MV X-ray beam at Bristol Hospital in real-time in an upstream position to the patient without clinically significant disturbance of the beam (0.1% attenuation). MAPSs can be made very thin (~20 μm) with still a very good signal-to-noise performance. The VANILLA can reconstruct the collimated beam edge with approximately 64 μm precision.

  19. A reconstruction method for cone-beam differential x-ray phase-contrast computed tomography.

    Science.gov (United States)

    Fu, Jian; Velroyen, Astrid; Tan, Renbo; Zhang, Junwei; Chen, Liyuan; Tapfer, Arne; Bech, Martin; Pfeiffer, Franz

    2012-09-10

    Most existing differential phase-contrast computed tomography (DPC-CT) approaches are based on three kinds of scanning geometries, described by parallel-beam, fan-beam and cone-beam. Due to the potential of compact imaging systems with magnified spatial resolution, cone-beam DPC-CT has attracted significant interest. In this paper, we report a reconstruction method based on a back-projection filtration (BPF) algorithm for cone-beam DPC-CT. Due to the differential nature of phase contrast projections, the algorithm restrains from differentiation of the projection data prior to back-projection, unlike BPF algorithms commonly used for absorption-based CT data. This work comprises a numerical study of the algorithm and its experimental verification using a dataset measured with a three-grating interferometer and a micro-focus x-ray tube source. Moreover, the numerical simulation and experimental results demonstrate that the proposed method can deal with several classes of truncated cone-beam datasets. We believe that this feature is of particular interest for future medical cone-beam phase-contrast CT imaging applications.

  20. Controlling backstreaming ions from X-ray converter targets with time varying final focusing solenoidal lens and beam energy variation

    Energy Technology Data Exchange (ETDEWEB)

    Caporaso, G J; Chen, Yu-Jiuan; Paul, A

    1998-08-20

    Backstreaming ions emitted from an x-ray converter hit by a tightly focused intense electron beam can form an ion focusing channel and over-focus the electron beam. As the ions move upstream in time, the net focusing strength increases. The final beam spot size on the target would then change in time and typically be larger than intended. We have developed a model to estimate the backstreaming ions' neutralization factor in a potential sheath near the target surface and away from the sheath. Performance of high resolution x-ray radiography facilities requires high current electron beams to be focused to a millimeter spot size on an x-ray converter through out the entire current pulse. We have studied the possibility of maintaining a constant final spot size for the entire pulse by using either a time varying final focusing solenoid field or beam energy variation to compensate the time varying ion focusing effects

  1. X-ray phase contrast imaging of the breast: Analysis of tissue simulating materials

    Energy Technology Data Exchange (ETDEWEB)

    Vedantham, Srinivasan; Karellas, Andrew [Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655 (United States)

    2013-04-15

    Purpose: Phase contrast imaging, particularly of the breast, is being actively investigated. The purpose of this work is to investigate the x-ray phase contrast properties of breast tissues and commonly used breast tissue substitutes or phantom materials with an aim of determining the phantom materials best representative of breast tissues. Methods: Elemental compositions of breast tissues including adipose, fibroglandular, and skin were used to determine the refractive index, n= 1 -{delta}+i {beta}. The real part of the refractive index, specifically the refractive index decrement ({delta}), over the energy range of 5-50 keV were determined using XOP software (version 2.3, European Synchrotron Radiation Facility, France). Calcium oxalate and calcium hydroxyapatite were considered to represent the material compositions of microcalcifications in vivo. Nineteen tissue substitutes were considered as possible candidates to represent adipose tissue, fibroglandular tissue and skin, and four phantom materials were considered as possible candidates to represent microcalcifications. For each material, either the molecular formula, if available, or the elemental composition based on weight fraction, was used to determine {delta}. At each x-ray photon energy, the absolute percent difference in {delta} between the breast tissue and the substitute material was determined, from which three candidates were selected. From these candidate tissue substitutes, the material that minimized the absolute percent difference in linear attenuation coefficient {mu}, and hence {beta}, was considered to be best representative of that breast tissue. Results: Over the energy range of 5-50 keV, while the {delta} of CB3 and fibroglandular tissue-equivalent material were within 1% of that of fibroglandular tissue, the {mu} of fibroglandular tissue-equivalent material better approximated the fibroglandular tissue. While the {delta} of BR10 and adipose tissue-equivalent material were within 1% of

  2. Simulating systematic errors in X-ray absorption spectroscopy experiments: Sample and beam effects

    Energy Technology Data Exchange (ETDEWEB)

    Curis, Emmanuel [Laboratoire de Biomathematiques, Faculte de Pharmacie, Universite Rene, Descartes (Paris V)-4, Avenue de l' Observatoire, 75006 Paris (France)]. E-mail: emmanuel.curis@univ-paris5.fr; Osan, Janos [KFKI Atomic Energy Research Institute (AEKI)-P.O. Box 49, H-1525 Budapest (Hungary); Falkenberg, Gerald [Hamburger Synchrotronstrahlungslabor (HASYLAB), Deutsches Elektronen-Synchrotron (DESY)-Notkestrasse 85, 22607 Hamburg (Germany); Benazeth, Simone [Laboratoire de Biomathematiques, Faculte de Pharmacie, Universite Rene, Descartes (Paris V)-4, Avenue de l' Observatoire, 75006 Paris (France); Laboratoire d' Utilisation du Rayonnement Electromagnetique (LURE)-Ba-hat timent 209D, Campus d' Orsay, 91406 Orsay (France); Toeroek, Szabina [KFKI Atomic Energy Research Institute (AEKI)-P.O. Box 49, H-1525 Budapest (Hungary)

    2005-07-15

    The article presents an analytical model to simulate experimental imperfections in the realization of an X-ray absorption spectroscopy experiment, performed in transmission or fluorescence mode. Distinction is made between sources of systematic errors on a time-scale basis, to select the more appropriate model for their handling. For short time-scale, statistical models are the most suited. For large time-scale, the model is developed for sample and beam imperfections: mainly sample inhomogeneity, sample self-absorption, beam achromaticity. The ability of this model to reproduce the effects of these imperfections is exemplified, and the model is validated on real samples. Various potential application fields of the model are then presented.

  3. An inexpensive spectroscopic beam monitor for hard X-ray synchrotron applications

    CERN Document Server

    Owens, A; Den Hartog, R; Quarati, F; Webb, A; Welter, E; HASYLAB at DESY, Hamburg, Germany

    2007-01-01

    We describe an inexpensive beam monitor for hard X-ray synchrotron applications which has good spectroscopic abilities and can operate without cooling. The device is centred on an inexpensive, commercial off-the-shelf, large area (1.2 × 1.2 mm2) Si photodiode operated in single counting mode. Measurements carried out at the HASYLAB synchrotron research facility have shown that it is fully spectroscopic across the energy range 8 keV to 100 keV with a measured energy resolution of ~ 1.2 keV FWHM at room temperature. The measured resolutions were found to be the same under pencil-beam and full-area illumination, indicating uniform crystallinity and stoichiometry of the bulk. The low cost, simplicity and performance of the detector make it suitable for a wider range of applications, e.g., in undergraduate laboratory experiments.

  4. Improved Scatter Correction in X-Ray Cone Beam CT with Moving Beam Stop Array Using Johns' Equation

    CERN Document Server

    Yan, Hao; Tang, Shaojie; Xu, Qiong

    2014-01-01

    In this paper, an improved scatter correction with moving beam stop array (BSA) for x-ray cone beam (CB) CT is proposed. Firstly, correlation between neighboring CB views is deduced based on John's Equation. Then, correlation-based algorithm is presented to complement the incomplete views by using the redundancy (over-determined information) in CB projections. Finally, combining the algorithm with scatter correction method using moving BSA, where part of primary radiation is blocked and incomplete projections are acquired, an improved correction method is proposed. Effectiveness and robustness is validated by Monte Carlo (MC) simulation with EGSnrc on humanoid phantom.

  5. Creating flat-top X-ray beams by applying surface profiles of alternating curvature to deformable piezo bimorph mirrors.

    Science.gov (United States)

    Sutter, John P; Alcock, Simon G; Kashyap, Yogesh; Nistea, Ioana; Wang, Hongchang; Sawhney, Kawal

    2016-11-01

    Beam shaping is becoming increasingly important for synchrotron X-ray applications. Although routine for visible light lasers, this is challenging for X-rays due to the limited source coherence and extreme optical tolerances required for the shaping mirrors. In deliberate defocusing, even surface errors piezo bimorph mirrors permit a continuous range of X-ray beam sizes and shapes. A new theory is developed for applying non-periodic modifications of alternating curvature to optical surfaces. The position and length of the segments may be freely chosen. For the first time, surface modifications of alternating curvature are applied to bimorph mirrors to generate non-Gaussian X-ray beam profiles of specified width. The new theory's freedom is exploited to choose the segments to match the polishing errors of medium wavelength (>10 mm) and the piezos' influence on the mirror's figure. Five- and seven-segment modifications of alternating curvature are calculated and verified by visible light and X-ray metrology. The latter yields beam profiles with less striation than those made by defocusing. Remaining beam striations are explained by applying geometrical optics to the deviations from the ideal surface modifications of alternating curvature.

  6. The beam-based calibration of an X-ray pinhole camera at SSRF

    Institute of Scientific and Technical Information of China (English)

    LENG Yong-Bin; HUANG Guo-Qing; ZHANG Man-Zhou; CHEN Zhi-Chu; CHEN Jie; YE Kai-Rong

    2012-01-01

    A pinhole camera for imaging X-ray synchrotron radiation from a dipole magnet is now in operation at the Shanghai Synchrotron Radiation Facility (SSRF) storage ring.The electron beam size is derived by unfolding the radiation image and the point spread function (PSF) with deconvolution techniques.The performance of the pinhole is determined by the accuracy of the PSF measurement.This article will focus on a beam-based calibration scheme to measure the PSF system by varying the beam images with different quadrupole settings and fitting them with the corresponding theoretical beam sizes.Applying this method at SSRF,the PSF value of the pinhole is revised from 37 to 44 μm.The deviation in beam size between the theoretical value and the measured value is minimized to 4% after calibration.This optimization allows us to observe the horizontal disturbance due to injection down to as small as 0.5 μm.

  7. Human breast cancer in vitro: matching histo-pathology with small-angle x-ray scattering and diffraction enhanced x-ray imaging

    Science.gov (United States)

    Fernández, Manuel; Keyriläinen, Jani; Serimaa, Ritva; Torkkeli, Mika; Karjalainen-Lindsberg, Marja-Liisa; Leidenius, Marjut; von Smitten, Karl; Tenhunen, Mikko; Fiedler, Stefan; Bravin, Alberto; Weiss, Thomas M.; Suortti, Pekka

    2005-07-01

    Twenty-eight human breast tumour specimens were studied with small-angle x-ray scattering (SAXS), and 10 of those were imaged by the diffraction enhanced x-ray imaging (DEI) technique. The sample diameter was 20 mm and the thickness 1 mm. Two examples of ductal carcinoma are illustrated by histology images, DEI, and maps of the collagen d-spacing and scattered intensity in the Porod regime, which characterize the SAXS patterns from collagen-rich regions of the samples. Histo-pathology reveals the cancer-invaded regions, and the maps of the SAXS parameters show that in these regions the scattering signal differs significantly from scattering by the surrounding tissue, indicating a degradation of the collagen structure in the invaded regions. The DEI images show the borders between collagen and adipose tissue and provide a co-ordinate system for tissue mapping by SAXS. In addition, degradation of the collagen structure in an invaded region is revealed by fading contrast of the DEI refraction image. The 28 samples include fresh, defrosted tissue and formalin-fixed tissue. The d-values with their standard deviations are given. In the fresh samples there is a systematic 0.76% increase of the d-value in the invaded regions, averaged over 11 samples. Only intra-sample comparisons are made for the formalin-fixed samples, and with a long fixation time, the difference in the d-value stabilizes at about 0.7%. The correspondence between the DEI images, the SAXS maps and the histo-pathology suggests that definitive information on tumour growth and malignancy is obtained by combining these x-ray methods.

  8. Automated marker tracking using noisy X-ray images degraded by the treatment beam

    Energy Technology Data Exchange (ETDEWEB)

    Wisotzky, E. [Fraunhofer Institute for Production Systems and Design Technology (IPK), Berlin (Germany); German Cancer Research Center (DKFZ), Heidelberg (Germany); Fast, M.F.; Nill, S. [The Royal Marsden NHS Foundation Trust, London (United Kingdom). Joint Dept. of Physics; Oelfke, U. [The Royal Marsden NHS Foundation Trust, London (United Kingdom). Joint Dept. of Physics; German Cancer Research Center (DKFZ), Heidelberg (Germany)

    2015-09-01

    This study demonstrates the feasibility of automated marker tracking for the real-time detection of intrafractional target motion using noisy kilovoltage (kV) X-ray images degraded by the megavoltage (MV) treatment beam. The authors previously introduced the in-line imaging geometry, in which the flat-panel detector (FPD) is mounted directly underneath the treatment head of the linear accelerator. They found that the 121 kVp image quality was severely compromised by the 6 MV beam passing through the FPD at the same time. Specific MV-induced artefacts present a considerable challenge for automated marker detection algorithms. For this study, the authors developed a new imaging geometry by re-positioning the FPD and the X-ray tube. This improved the contrast-to-noise-ratio between 40% and 72% at the 1.2 mAs/image exposure setting. The increase in image quality clearly facilitates the quick and stable detection of motion with the aid of a template matching algorithm. The setup was tested with an anthropomorphic lung phantom (including an artificial lung tumour). In the tumour one or three Calypso {sup registered} beacons were embedded to achieve better contrast during MV radiation. For a single beacon, image acquisition and automated marker detection typically took around 76±6 ms. The success rate was found to be highly dependent on imaging dose and gantry angle. To eliminate possible false detections, the authors implemented a training phase prior to treatment beam irradiation and also introduced speed limits for motion between subsequent images.

  9. Influence of Polarization of the Incident Beam on Integrated Intensities in X-Ray Energy-Dispersive Diffractometry

    DEFF Research Database (Denmark)

    Olsen, J. Staun; Buras, B.; Jensen, T.

    1978-01-01

    Polarization measurements of the primary X-ray beam produced by thick copper and tungsten anodes are reported and formulas derived for integrated intensities of Bragg reflections in energy-dispersive diffractometry with the polarization of the primary beam taken into account. It was found...

  10. Nanoscale radiation transport and clinical beam modeling for gold nanoparticle dose enhanced radiotherapy (GNPT) using X-rays.

    Science.gov (United States)

    Zygmanski, Piotr; Sajo, Erno

    2016-01-01

    We review radiation transport and clinical beam modelling for gold nanoparticle dose-enhanced radiotherapy using X-rays. We focus on the nanoscale radiation transport and its relation to macroscopic dosimetry for monoenergetic and clinical beams. Among other aspects, we discuss Monte Carlo and deterministic methods and their applications to predicting dose enhancement using various metrics.

  11. X-ray diffraction from bone employing annular and semi-annular beams.

    Science.gov (United States)

    Dicken, A J; Evans, J P O; Rogers, K D; Stone, N; Greenwood, C; Godber, S X; Prokopiou, D; Clement, J G; Lyburn, I D; Martin, R M; Zioupos, P

    2015-08-07

    There is a compelling need for accurate, low cost diagnostics to identify osteo-tissues that are associated with a high risk of fracture within an individual. To satisfy this requirement the quantification of bone characteristics such as 'bone quality' need to exceed that provided currently by densitometry. Bone mineral chemistry and microstructure can be determined from coherent x-ray scatter signatures of bone specimens. Therefore, if these signatures can be measured, in vivo, to an appropriate accuracy it should be possible by extending terms within a fracture risk model to improve fracture risk prediction.In this preliminary study we present an examination of a new x-ray diffraction technique that employs hollow annular and semi-annular beams to measure aspects of 'bone quality'. We present diffractograms obtained with our approach from ex vivo bone specimens at Mo Kα and W Kα energies. Primary data is parameterized to provide estimates of bone characteristics and to indicate the precision with which these can be determined.

  12. Investigation of GEM-Micromegas detector on X-ray beam of synchrotron radiation

    Science.gov (United States)

    Zhang, Yu-Lian; Qi, Hui-Rong; Hu, Bi-Tao; Fan, Sheng-Nan; Wang, Bo; Liu, Mei; Zhang, Jian; Liu, Rong-Guang; Chang, Guang-Cai; Liu, Peng; Ouyang, Qun; Chen, Yuan-Bo; Yi, Fu-Ting

    2014-04-01

    To reduce the discharge of the standard bulk Micromegas and GEM detectors, a GEM-Micromegas detector was developed at the Institute of High Energy Physics. Taking into account the advantages of the two detectors, one GEM foil was set as a preamplifier on the mesh of Micromegas in the structure and the GEM preamplification decreased the working voltage of Micromegas to significantly reduce the effect of the discharge. At the same gain, the spark probability of the GEM-Micromegas detector can be reduced to a factor 0.01 compared to the standard Micromegas detector, and an even higher gain could be obtained. This paper describes the performance of the X-ray beam detector that was studied at 1W2B Laboratory of Beijing Synchrotron Radiation Facility. Finally, the result of the energy resolution under various X-ray energies was given in different working gases. This indicates that the GEM-Micromegas detector has an energy response capability in an energy range from 6 keV to 20 keV and it could work better than the standard bulk-Micromegas.

  13. The evaluation of breast tissues removed during reductive mammaplasty with dual energy X-ray absorptiometry

    Energy Technology Data Exchange (ETDEWEB)

    De Lorenzo, Antonino [Division of Human Nutrition, University of Tor Vergata in Rome (Italy); Gravante, Gianpiero [Division of Human Nutrition, University of Tor Vergata in Rome (Italy); Department of Surgery, Whipps Cross University Hospital, London (United Kingdom)], E-mail: ggravante@hotmail.com; Sorge, Roberto [Laboratory of Biometry, University of Tor Vergata in Rome (Italy); Nicoli, Fabio; Caruso, Riccardo; Araco, Antonino [Department of Plastic Surgery, University of Tor Vergata in Rome (Italy); Servidio, Michele [Division of Human Nutrition, University of Tor Vergata in Rome (Italy); Orlandi, Augusto [Department of Biopathology, Anatomic Pathology Institute, University of Tor Vergata in Rome (Italy); Cervelli, Valerio [Department of Plastic Surgery, University of Tor Vergata in Rome (Italy)

    2009-06-15

    Purpose: We conducted a case-control study in which patients were evaluated with dual energy X-ray absorptiometry (DEXA) before and after breast reduction surgery, and results were correlated with the histological examination. Our goal was to confirm the DEXA as a precise technique for the measurement of breast composition, in order to propose it for the preoperative evaluation of plastic surgery patients. Materials and methods: We prospectively recruited all women that underwent reduction mammaplasty and excluded patients with contraindications to the operation or those that previously underwent bariatric surgery to reduce their weight. Patients were evaluated with DEXA 1 week before and after surgery. Results: From February to October 2006 we recruited 25 patients. The statistical analysis found a significant reduction of weight, BMI, regional fat free mass and fat mass after the operation. The comparison between DEXA and the histological analysis produced a correlation r = 0.989 (r{sup 2} = 0.978), with a predictivity of 98% and a percentage of error 8.3% (95% confidence intervals -252.6, 273.7; 95% limits of agreements of Bland and Altman -436.0, 457.1). Similar results were obtained with the analysis of fat. Conclusions: Our study demonstrated that conventional segmental DEXA is a very precise technique to measure the amount of tissue removed in breast reductions and could open future application in the preoperative assessment of patients undergoing such operations.

  14. X-ray beam hardening correction for measuring density in linear accelerator industrial computed tomography

    Institute of Scientific and Technical Information of China (English)

    ZHOU Ri-Feng; WANG Jue; CHEN Wei-Min

    2009-01-01

    Due to X-ray attenuation being approximately proportional to material density, it is possible to measure the inner density through Industrial Computed Tomography (ICT) images accurately. In practice, however, a number of factors including the non-linear effects of beam hardening and diffuse scattered radia-tion complicate the quantitative measurement of density variations in materials. This paper is based on the linearization method of beam hardening correction, and uses polynomial fitting coefficient which is obtained by the curvature of iron polychromatic beam data to fit other materials. Through theoretical deduction, the paper proves that the density measure error is less than 2% if using pre-filters to make the spectrum of linear accelerator range mainly 0.3 MeV to 3 MeV. Experiment had been set up at an ICT system with a 9 MeV electron linear accelerator. The result is satisfactory. This technique makes the beam hardening correction easy and simple, and it is valuable for measuring the ICT density and making use of the CT images to recognize materials.

  15. Computer simulations of X-ray six-beam diffraction in a perfect silicon crystal. I.

    Science.gov (United States)

    Kohn, V G; Khikhlukha, D R

    2016-05-01

    This paper reports computer simulations of the transmitted-beam intensity distribution for the case of six-beam (000, 220, 242, 044, -224, -202) diffraction of X-rays in a perfect silicon crystal of thickness 1 mm. Both the plane-wave angular dependence and the six-beam section topographs, which are usually obtained in experiments with a restricted beam (two-dimensional slit), are calculated. The angular dependence is calculated in accordance with Ewald's theory. The section topographs are calculated from the angular dependence by means of the fast Fourier transformation procedure. This approach allows one to consider, for the first time, the transformation of the topograph's structure due to the two-dimensional slit sizes and the distance between the slit and the detector. The results are in good agreement with the results of other works and with the experimental data. This method of calculation does not require a supercomputer and it was performed on a standard laptop. A detailed explanation of the main features of the diffraction patterns at different distances between the slit and the detector is presented.

  16. Comparison of SOFC Cathode Microstructure Quantified using X-ray Nanotomography and Focused Ion Beam - Scanning Electron Microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, George J. [Univ. of Connecticut, Storrs, CT (United States); Harris, William H. [Univ. of Connecticut, Storrs, CT (United States); Lombardo, Jeffrey J. [Univ. of Connecticut, Storrs, CT (United States); Izzo, Jr., John R. [Univ. of Connecticut, Storrs, CT (United States); Chiu, W. K. S. [Univ. of Connecticut, Storrs, CT (United States); Tanasini, Pietro [Ecole Ploytechnique Federale de Lausanne (Switzerland); Cantoni, Marco [Ecole Ploytechnique Federale de Lausanne (Switzerland); Van herle, Jan [Ecole Ploytechnique Federale de Lausanne (Switzerland); Comninellis, Christos [Ecole Ploytechnique Federale de Lausanne (Switzerland); Andrews, Joy C. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Liu, Yijin [SLAC National Accelerator Lab., Menlo Park, CA (United States); Pianetta, Piero [SLAC National Accelerator Lab., Menlo Park, CA (United States); Chu, Yong [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2011-03-24

    X-ray nanotomography and focused ion beam scanning electron microscopy (FIB-SEM) have been applied to investigate the complex 3D microstructure of solid oxide fuel cell (SOFC) electrodes at spatial resolutions of 45 nm and below. The application of near edge differential absorption for x-ray nanotomography and energy selected backscatter detection for FIB–SEM enable elemental mapping within the microstructure. Using these methods, non-destructive 3D x-ray imaging and FIB–SEM serial sectioning have been applied to compare three-dimensional elemental mapping of the LSM, YSZ, and pore phases in the SOFC cathode microstructure. The microstructural characterization of an SOFC cathode is reported based on these measurements. The results presented demonstrate the viability of x-ray nanotomography as a quantitative characterization technique and provide key insights into the SOFC cathode microstructure.

  17. A split-beam probe-pump-probe scheme for femtosecond time resolved protein X-ray crystallography

    Directory of Open Access Journals (Sweden)

    Jasper J. van Thor

    2015-01-01

    Full Text Available In order to exploit the femtosecond pulse duration of X-ray Free-Electron Lasers (XFEL operating in the hard X-ray regime for ultrafast time-resolved protein crystallography experiments, critical parameters that determine the crystallographic signal-to-noise (I/σI must be addressed. For single-crystal studies under low absorbed dose conditions, it has been shown that the intrinsic pulse intensity stability as well as mode structure and jitter of this structure, significantly affect the crystallographic signal-to-noise. Here, geometrical parameters are theoretically explored for a three-beam scheme: X-ray probe, optical pump, X-ray probe (or “probe-pump-probe” which will allow experimental determination of the photo-induced structure factor amplitude differences, ΔF, in a ratiometric manner, thereby internally referencing the intensity noise of the XFEL source. In addition to a non-collinear split-beam geometry which separates un-pumped and pumped diffraction patterns on an area detector, applying an additional convergence angle to both beams by focusing leads to integration over mosaic blocks in the case of well-ordered stationary protein crystals. Ray-tracing X-ray diffraction simulations are performed for an example using photoactive yellow protein crystals in order to explore the geometrical design parameters which would be needed. The specifications for an X-ray split and delay instrument that implements both an offset angle and focused beams are discussed, for implementation of a probe-pump-probe scheme at the European XFEL. We discuss possible extension of single crystal studies to serial femtosecond crystallography, particularly in view of the expected X-ray damage and ablation due to the first probe pulse.

  18. Single-shot radiography using X-rays from Compton-backscattering with laser-wakefield accelerated electron beams

    CERN Document Server

    Döpp, A; Thaury, C; Gautier, J; Andriyash, I; Lifschitz, A; Goddet, J-P; Tafzi, A; Malka, V; Rousse, A; Phuoc, K Ta

    2015-01-01

    We present results from the production of high energy femtosecond X-rays by Compton-backscattering of an intense femtosecond laser pulse with quasi-monoenergetic laser-accelerated electron beams using a plasma mirror. In our parameter regime electrons of $\\sim$ 150 MeV peak energy emit a high energy radiation beam with a broad spectrum extending up to $\\sim$ 500 keV. The photon yield from the source is sufficiently high to illuminate a centimeter-size sample placed 90 centimeters behind the source and record a single-shot radiograph. The small diameter of the laser-accelerated electron beams translates into a micrometer X-ray source size, making it a promising candidate for advanced X-ray imaging techniques as e.g. propagation-based phase contrast imaging.

  19. Simulations of x-ray speckle-based dark-field and phase-contrast imaging with a polychromatic beam

    Energy Technology Data Exchange (ETDEWEB)

    Zdora, Marie-Christine, E-mail: marie-christine.zdora@diamond.ac.uk [Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, 85748 Garching (Germany); Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom); Department of Physics & Astronomy, University College London, London WC1E 6BT (United Kingdom); Thibault, Pierre [Department of Physics & Astronomy, University College London, London WC1E 6BT (United Kingdom); Pfeiffer, Franz [Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, 85748 Garching (Germany); Zanette, Irene [Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, 85748 Garching (Germany); Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom)

    2015-09-21

    Following the first experimental demonstration of x-ray speckle-based multimodal imaging using a polychromatic beam [I. Zanette et al., Phys. Rev. Lett. 112(25), 253903 (2014)], we present a simulation study on the effects of a polychromatic x-ray spectrum on the performance of this technique. We observe that the contrast of the near-field speckles is only mildly influenced by the bandwidth of the energy spectrum. Moreover, using a homogeneous object with simple geometry, we characterize the beam hardening artifacts in the reconstructed transmission and refraction angle images, and we describe how the beam hardening also affects the dark-field signal provided by speckle tracking. This study is particularly important for further implementations and developments of coherent speckle-based techniques at laboratory x-ray sources.

  20. Characterization of the 46.9-nm soft X-ray laser beam from a capillary discharge

    Science.gov (United States)

    Barnwal, S.; Prasad, Y. B. S. R.; Nigam, S.; Aneesh, K.; Sharma, M. L.; Kushwaha, R. P.; Tripathi, P. K.; Naik, P. A.; Chakera, J. A.; Navathe, C. P.; Gupta, P. D.

    2014-10-01

    Intense lasing had been obtained from argon plasma in the soft X-ray region from a capillary discharge plasma system. Different diagnostics have been used to characterize the lasing properties by recording the temporal, spatial, and spectral profiles of the emission. The divergence measurement indicates that the soft X-ray laser beam has good directionality with a divergence of 3.5 mrad. The spectrum of the laser beam measured using a transmission grating showed intense lasing line at 46.9 nm. Diffraction orders as high as 10th orders were observed. The temporal profile recorded with a vacuum diode showed a distinct laser peak with a pulse width ~1.2 ns (FWHM). In addition, the coherence of the X-ray laser beam was also confirmed from the high-contrast interference fringes (visibility ~85 %) recorded using double slits.

  1. Studies on high-quality electron beams and tunable x-ray sources produced by laser wakefield accelerators

    Science.gov (United States)

    Zeng, Ming; Luo, Ji; Chen, Min; Sheng, Zheng-Ming

    2016-11-01

    The applications of laser wake field accelerators (LWFA) rely heavily on the quality of produced high energy electron beams and X-ray sources. We present our recent progress on this issue. Firstly we propose a bichromatic laser ionization injection scheme for obtaining high quality electron beams. With the laser pulse combinations of 800 nm and 267 nm, or 2400 nm and 800 nm in wavelengths, electron beams with energy spread of 1% or lower can be produced. Secondly we propose polarization tunable X-ray sources based on LWFA. By shooting a laser pulse into a preformed plasma channel with a skew angle referring to the channel axis, the plasma channel can act as a helical undulator for elliptically polarized X-rays.

  2. Solar Hard X-ray Source Sizes in a Beam-Heated and Ionised Chromosphere

    CERN Document Server

    O'Flannagain, A; Gallagher, P T

    2014-01-01

    Solar flare hard X-rays (HXRs) are produced as bremsstrahlung when an accelerated population of electrons interacts with the dense chromospheric plasma. HXR observations presented by using the Ramaty High-Energy Solar Spectroscopic Imager (RHESSI) have shown that HXR source sizes are 3-6 times more extended in height than those predicted by the standard collisional thick target model (CTTM). Several possible explanations have been put forward including the multi-threaded nature of flare loops, pitch-angle scattering, and magnetic mirroring. However, the nonuniform ionisation (NUI) structure along the path of the electron beam has not been fully explored as a solution to this problem. Ionised plasma is known to be less effective at producing nonthermal bremsstrahlung HXRs when compared to neutral plasma. If the peak HXR emission was produced in a locally ionised region within the chromosphere, the intensity of emission will be preferentially reduced around this peak, resulting in a more extended source. Due to...

  3. Evaluation of a tissue equivalent ionization chamber in X-ray beams

    Energy Technology Data Exchange (ETDEWEB)

    Perini, Ana Paula; Neves, Lucio Pereira; Santos, William de Souza; Caldas, Linda V.E., E-mail: aperini@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Frimaio, Audrew [Seal Technology Ind. Com. Ltda, Sao Paulo, SP (Brazil); Costa, Paulo R. [Universidade de Sao Paulo (USP/IF), Sao Paulo, SP (Brazil). Inst. de Fisica

    2014-07-01

    Tissue equivalent materials present a variety of uses, including routine quality assurance and quality control programs in both diagnostic and therapeutic physics. They are frequently used in research facilities to measure doses delivered to patients undergoing various clinical procedures. This work presents the development and evaluation of a tissue equivalent ionization chamber, with a sensitive volume of 2.3 cm{sup 3}, for routine use in X-rays beams. This ionization chamber was developed at the Calibration Laboratory/IPEN. The new tissue equivalent material was developed at the Physics Institute of the University of Sao Paulo. In order to evaluate the dosimetric performance of the new ionization chamber, several tests described by international standards were undertaken, and all results were within the recommended limits. (author)

  4. The influence of an extrapolation chamber over the low energy X-ray beam radiation field

    Energy Technology Data Exchange (ETDEWEB)

    Tanuri de F, M. T.; Da Silva, T. A., E-mail: mttf@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear / CNEN, Av. Pte. Antonio Carlos 6627, 31270-901 Pampulha, Belo Horizonte, Minas Gerais (Brazil)

    2016-10-15

    The extrapolation chambers are detectors whose sensitive volume can be modified by changing the distance between the electrodes and has been widely used for beta particles primary measurement system. In this work, was performed a PTW 23392 extrapolation chamber Monte Carlo simulation, by mean the MCNPX code. Although the sensitive volume of an extrapolation chamber can be reduced to very small size, their packaging is large enough to modify the radiation field and change the absorbed dose measurements values. Experiments were performed to calculate correction factors for this purpose. The validation of the Monte Carlo model was done by comparing the spectra obtained with a CdTe detector according to the ISO 4037 criteria. Agreements smaller than 5% for half value layers, 10% for spectral resolution and 1% for mean energy, were found. It was verified that the correction factors are dependent of the X-ray beam quality. (Author)

  5. Dosimetry of x-ray beams: The measure of the problem

    Energy Technology Data Exchange (ETDEWEB)

    de Castro, T.M.

    1986-08-01

    This document contains the text of an oral presentation on dosimetry of analytical x-ray equipment presented at the Denver X-Ray Conference. Included are discussions of sources of background radiation, exposure limits from occupational sources, and the relationship of these sources to the high dose source of x-rays found in analytical machines. The mathematical basis of x-ray dosimetry is reviewed in preparation for more detailed notes on personnel dosimetry and the selection of the most appropriate dosimeter for a specific application. The presentation concludes with a discussion common to previous x-ray equipment accidents. 2 refs. (TEM)

  6. An evaluation of Genipin gel as a water equivalent dosimeter for megavoltage electron beams and kilovoltage x-ray beams

    Energy Technology Data Exchange (ETDEWEB)

    Gorjiara, Tina; Hill, Robin; Kuncic, Zdenka; Bosi, Stephen; Baldock, Clive, E-mail: clive.baldock@sydney.edu.a

    2010-11-01

    Genipin gel is a radiochromic gel with the potential to be used as a three dimensional (3D) dosimeter. An ideal dosimeter should present radiologically water equivalent properties. In this work, we have evaluated the water equivalency of genipin gel by calculating its radiological properties, such as mass and electron density, effective atomic number, fractional interaction probabilities, mass energy absorption coefficient and mass stopping powers as well as depth doses for kilovoltage x-ray and megavoltage electron beams. Based on the results of this study, we conclude that genipin gel is a water equivalent dosimeter.

  7. A compact micro-beam system using a tapered glass capillary for proton-induced X-ray radiography

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Jun [Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550 (Japan)], E-mail: jhasegaw@nr.titech.ac.jp; Shiba, Shigeki; Fukuda, Hitoshi; Oguri, Yoshiyuki [Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550 (Japan)

    2008-05-15

    A compact micro-beam system, containing a tapered glass capillary tube with a tip diameter on the order of 10 {mu}m, was constructed to examine the applicability of capillary-generated micro-beams to high-contrast radiography based on proton-induced quasi-monochromatic X-rays. The transport efficiency of swift protons (2-3 MeV) through the capillary was examined as a function of the capillary tilt angle and the capillary tip diameter. We obtained transport efficiencies of approximately three times larger than would be expected from the geometrical shape of the capillary. This enhancement indicates that a focusing effect occurred in the capillary. A metallic thin foil was irradiated with the micro-beam and quasi-monochromatic X-rays were produced. By calculating the X-ray yields induced by proton bombardment in the foil and comparing them with the X-ray counts observed at the detector, the throughput efficiency of the X-ray imaging system was evaluated. We demonstrated magnification radiography of a small object to show that a spatial resolution on the order of 10 {mu}m was achievable in our system.

  8. Breast tissue classification using x-ray scattering measurements and multivariate data analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ryan, Elaine A; Farquharson, Michael J [School of Allied Health Sciences, City University, Charterhouse Square, London EC1M 6PA (United Kingdom)

    2007-11-21

    This study utilized two radiation scatter interactions in order to differentiate malignant from non-malignant breast tissue. These two interactions were Compton scatter, used to measure the electron density of the tissues, and coherent scatter to obtain a measure of structure. Measurements of these parameters were made using a laboratory experimental set-up comprising an x-ray tube and HPGe detector. The breast tissue samples investigated comprise five different tissue classifications: adipose, malignancy, fibroadenoma, normal fibrous tissue and tissue that had undergone fibrocystic change. The coherent scatter spectra were analysed using a peak fitting routine, and a technique involving multivariate analysis was used to combine the peak fitted scatter profile spectra and the electron density values into a tissue classification model. The number of variables used in the model was refined by finding the sensitivity and specificity of each model and concentrating on differentiating between two tissues at a time. The best model that was formulated had a sensitivity of 54% and a specificity of 100%.

  9. Breast tissue classification using x-ray scattering measurements and multivariate data analysis

    Science.gov (United States)

    Ryan, Elaine A.; Farquharson, Michael J.

    2007-11-01

    This study utilized two radiation scatter interactions in order to differentiate malignant from non-malignant breast tissue. These two interactions were Compton scatter, used to measure the electron density of the tissues, and coherent scatter to obtain a measure of structure. Measurements of these parameters were made using a laboratory experimental set-up comprising an x-ray tube and HPGe detector. The breast tissue samples investigated comprise five different tissue classifications: adipose, malignancy, fibroadenoma, normal fibrous tissue and tissue that had undergone fibrocystic change. The coherent scatter spectra were analysed using a peak fitting routine, and a technique involving multivariate analysis was used to combine the peak fitted scatter profile spectra and the electron density values into a tissue classification model. The number of variables used in the model was refined by finding the sensitivity and specificity of each model and concentrating on differentiating between two tissues at a time. The best model that was formulated had a sensitivity of 54% and a specificity of 100%.

  10. X-ray study of a test quadrant of the SODART telescopes using the expanded beam x-ray optics facility at the Daresbury synchrotron

    DEFF Research Database (Denmark)

    Christensen, Finn Erland; Hornstrup, Allan; Frederiksen, P.;

    1994-01-01

    The imaging properties of a test model of the SODART telescopes have been studied using an expanded beam X-ray facility at the Daresbury synchrotron. The encircled power and the point spread function at three energies 6.627 keV, 8.837 keV and 11.046 keV have been measured using 1D and 2D position......V the HPD is 2.5 - 3.0 arcmin for all detectors whereas it is somewhat larger at 11.046 keV for HEPC and LEPC but essentially unchanged for SIXA. Finally, the data are used to point to improvements that can be introduced during the manufacture of the flight telescopes....

  11. X-ray study of a SODART flight telescope using the expanded beam x-ray optics beamline at the Daresbury synchrotron

    DEFF Research Database (Denmark)

    Christensen, Finn Erland; Hornstrup, Allan; Frederiksen, P. K.;

    1995-01-01

    The on- and off-axis imaging properties of the first of two SODART flight telescopes have been studied using the expanded beam x-ray facility at the Daresbury synchrotron. From on- axis measurements the encircled power distribution and the point spread function at three energies 6.627 keV, 8.837 ke......V, and 11.046 keV have been measured using a one dimensional position sensitive detector. The data have been used to calculate the half power diameter (HPD) for three different SODART focal plane detectors, the high energy proportional counter (HEPC), the low energy proportional counter (LEPC) and the 19...... element solid state array detector (SIXA). We found that the HPD decreases with increasing energy due to poorer figure error of the outermost mirrors. The HPD falls in the range from 2.3 to 3 arcmin for all detectors. Residual misalignment of the individual quadrants of the telescope was found...

  12. Investigation of tomosynthetic perfusion measurements using the scanning-beam digital x-ray (SBDX) system

    Science.gov (United States)

    Nett, Brian E.; Chen, Guang-Hong; Van Lysel, Michael S.; Betts, Timothy; Speidel, Michael; Rowley, Howard A.; Aagaard Kienitz, Beverly D.; Mistretta, Charles A.

    2004-10-01

    The feasibility of making regional perfusion measurements using a tomosynthetic digital subtraction angiography (TDSA) acquisition has been demonstrated. The study of tomosynthetic perfusion measurements was motivated by the clinical desire for perfusion measurements in an interventional angiography suite. These pilot studies were performed using the scanning-beam digital x-ray (SBDX) system which is an inverse-geometry imaging device which utilizes an electromagnetically-scanned x-ray source, and a small CdTe direct conversion photon counting detector. The scanning electron source was used to acquire planar-tomographic images of a 12.5 x 12.5 cm field of view at a frame rate of 15 frames/sec during dynamic contrast injection. A beagle animal model was used to evaluate the tomosynthetic perfusion measurements. A manual bolus injection of iodinated contrast solution was used in order to resolve the parameters of the contrast pass curve. The acquired planar tomosynthetic dataset was reconstructed with a simple back-projection algorithm. Digital subtraction techniques were used to visualize the change in contrast agent intensity in each reconstructed plane. Given the TDSA images, region of interest based analysis was used in the selection of the image pixels corresponding to the artery and tissue bed. The mean transit time (MTT), regional cerebral blood volume (rCBV) and regional cerebral blood flow (rCBF) were extracted from the tomosynthetic data for selected regions in each of the desired reconstructed planes. For the purpose of this study, the arterial contrast enhancement curve was fit with a combination of gamma variate terms, and the MTT was calculated using a deconvolution based on the singular value decomposition (SVD). The results of the contrast pass curves derived with TDSA were consistent with the results from perfusion measurements as implemented with CT acquisition.

  13. Characterization of a Test for Invasive Breast Cancer Using X-ray Diffraction of Hair - Results of a Clinical Trial

    Directory of Open Access Journals (Sweden)

    Gary L. Corino

    2009-11-01

    Full Text Available Objective: To assess the performance of a test for breast cancer utilizing synchrotron x-ray diffraction analysis of scalp hair from women undergoing diagnostic radiology assessment. Design and Setting: A double-blinded clinical trial of women who attended diagnostic radiology clinics in Australia. Patients: 1796 women referred for diagnostic radiology, with no previous history of cancer. Main Outcome Measures: Sensitivity, specificity and accuracy of the hair test analysis compared to the gold standard of imaging followed by biopsy where indicated. Results: The hair-based assay had an overall accuracy of >77% and a negative predictive value of 99%. For all women, the sensitivity of both mammography and x-ray diffraction alone was 64%, but when used together the sensitivity rose to 86%. The sensitivity of the hair test for women under the age of 70 was 74%. Conclusion: In this large population trial the association between the presence of breast cancer and an altered hair fibre X-ray diffraction pattern previously reported has been confirmed. It appears that mammography and X-ray diffraction of hair detect different populations of breast cancers, and are synergistic when used together.

  14. X-ray phase-contrast tomosynthesis for improved breast tissue discrimination

    Energy Technology Data Exchange (ETDEWEB)

    Schleede, Simone, E-mail: Schleede@tum.de [Department of Physics and Institute of Medical Engineering, Technische Universität München, James-Franck-Strasse 1, 85748 Garching (Germany); Bech, Martin, E-mail: martin.bech@tum.de [Department of Physics and Institute of Medical Engineering, Technische Universität München, James-Franck-Strasse 1, 85748 Garching (Germany); Medical Radiation Physics, Lund University, 22185 Lund (Sweden); Grandl, Susanne, E-mail: Susanne.Grandl@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistr. 15, 81377 München (Germany); Sztrókay, Aniko, E-mail: Aniko.Sztrokay@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistr. 15, 81377 München (Germany); Herzen, Julia, E-mail: julia.herzen@hzg.de [Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Strasse 1, 21502 Geesthacht (Germany); Mayr, Doris, E-mail: doris.mayr@med.uni-muenchen.de [Institute of Pathology, Ludwig-Maximilians-Universität München, Thalkirchner Str. 36, 80337 Munich (Germany); Stockmar, Marco, E-mail: marco.stockmar@ph.tum.de [Department of Physics and Institute of Medical Engineering, Technische Universität München, James-Franck-Strasse 1, 85748 Garching (Germany); Potdevin, Guillaume, E-mail: potdevinguillaume@gmail.com [Department of Physics and Institute of Medical Engineering, Technische Universität München, James-Franck-Strasse 1, 85748 Garching (Germany); and others

    2014-03-15

    Purpose: Attenuation-based tomosynthesis has proven to successfully resolve the glandular tissue overlap present in mammography. However, the ability of tomosynthesis to differentiate tumorous and glandular tissue remains limited, due to the small differences in X-ray attenuation in breast tissue. One possibility to overcome this limitation and to further increase the diagnostic value of tomosynthesis exams, is the application of recently developed grating-based phase-contrast methods, which provide complementary information on the phase shift and the local scattering power of the sample. In this study, we report on first phase-contrast breast tomosynthesis results of a mastectomy sample slice with an invasive ductal carcinoma. Material and methods: A slice of a mastectomy sample with histologically proven invasive ductal cancer was imaged at the synchrotron radiation source ESRF (Grenoble, France). We used a two-grating interferometer setup at the ninth fractional Talbot distance and with an X-ray energy of 23 keV. In grating interferometry absorption, differential phase, and scattering images are recorded simultaneously. The tomosynthesis scan comprises 61 projections. Multimodal tomosynthesis results were reconstructed using a standard filtered back-projection approach. Our findings are supported by a comparison of tomographic views to histopathology. Results: Phase-contrast tomosynthesis combines the advantage of improved soft-tissue discrimination in phase-contrast imaging with the ability of tomosynthesis to provide a third dimension so that improved feature visibility is not hampered by superposition artifacts. Our results indicate superior diagnostic value due to the depth resolution supplied in tomosynthesis imaging; a region of necrotic tissue that is obscured in a projection image can clearly be depicted in one single tomosynthesis slice. Compared to absorption tomosynthesis alone, soft tissue contrast is significantly enhanced in phase

  15. Correlation of electron beams and hard x-ray emissions in ISTTOK Tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Jakubowski, L.; Malinowski, K.; Sadowski, M.J.; Zebrowski, J.; Rabinski, M.; Jakubowski, M.J. [National Centre for Nuclear Research (NCBJ), Otwock (Poland); Plyusnin, V.V.; Fernandes, H.; Silva, C.; Duarte, P. [Association Euratom/IST, Instituto de Plasmas e Fusao Nuclear, Instituto Superior Tecnico, Lisboa (Portugal)

    2013-11-15

    The paper reports on experimental studies of electron beams in the ISTTOK tokamak, those were performed by means of an improved four-channel detector. The Cherenkov-type detector measuring head was equipped with four radiators made of two types of alumina-nitrate (AlN) poly-crystals: machinable and translucent ones, both of 10 mm in diameter and 2.5 mm in thickness. The movable support that enabled the whole detectors to be placed inside the tokamak vacuum chamber, at chosen positions along the ISTTOK minor radius. Since the electron energy distribution is one of the most important characteristics of tokamak plasmas, the main aim of the study was to perform estimations of an energy spectrum of the recorded electrons. For this purpose the radiators were coated with molybdenum (Mo) layers of different thickness. The technique based on the use of Cherenkov-type detectors enabled the detection of fast electrons (of energy above 66 keV) and determination of their spatial and temporal characteristics in the ISTTOK experiment. Measurements of hard X-rays (HXR), which were emitted during ISTTOK discharges, have also been performed. Particular attention was paid to the correlation measurements of HXR pulses with run-away electron beams. (copyright 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  16. Transverse coherence properties of X-ray beams in third-generation synchrotron radiation sources

    CERN Document Server

    Geloni, Gianluca; Schneidmiller, Evgeni; Yurkov, Mikhail

    2008-01-01

    This article describes a complete theory of spatial coherence for undulator radiation sources. Current estimations of coherence properties often assume that undulator sources are quasi-homogeneous, like thermal sources, and rely on the application of the van Cittert-Zernike theorem for calculating the degree of transverse coherence. Such assumption is not adequate when treating third generation light sources, because the vertical(geometrical) emittance of the electron beam is comparable or even much smaller than the radiation wavelength in a very wide spectral interval that spans over four orders of magnitude (from 0.1 Angstrom up to 10^3 Angstrom). Sometimes, the so-called Gaussian-Schell model, that is widely used in statistical optics in the description of partially-coherent sources, is applied as an alternative to the quasi-homogeneous model. However, as we will demonstrate, this model fails to properly describe coherent properties of X-ray beams from non-homogeneous undulator sources. As a result, a more...

  17. Carbon-ion beam irradiation kills X-ray-resistant p53-null cancer cells by inducing mitotic catastrophe.

    Directory of Open Access Journals (Sweden)

    Napapat Amornwichet

    Full Text Available BACKGROUND AND PURPOSE: To understand the mechanisms involved in the strong killing effect of carbon-ion beam irradiation on cancer cells with TP53 tumor suppressor gene deficiencies. MATERIALS AND METHODS: DNA damage responses after carbon-ion beam or X-ray irradiation in isogenic HCT116 colorectal cancer cell lines with and without TP53 (p53+/+ and p53-/-, respectively were analyzed as follows: cell survival by clonogenic assay, cell death modes by morphologic observation of DAPI-stained nuclei, DNA double-strand breaks (DSBs by immunostaining of phosphorylated H2AX (γH2AX, and cell cycle by flow cytometry and immunostaining of Ser10-phosphorylated histone H3. RESULTS: The p53-/- cells were more resistant than the p53+/+ cells to X-ray irradiation, while the sensitivities of the p53+/+ and p53-/- cells to carbon-ion beam irradiation were comparable. X-ray and carbon-ion beam irradiations predominantly induced apoptosis of the p53+/+ cells but not the p53-/- cells. In the p53-/- cells, carbon-ion beam irradiation, but not X-ray irradiation, markedly induced mitotic catastrophe that was associated with premature mitotic entry with harboring long-retained DSBs at 24 h post-irradiation. CONCLUSIONS: Efficient induction of mitotic catastrophe in apoptosis-resistant p53-deficient cells implies a strong cancer cell-killing effect of carbon-ion beam irradiation that is independent of the p53 status, suggesting its biological advantage over X-ray treatment.

  18. A diffracted-beam monochromator for long linear detectors in X-ray diffractometers with Bragg-Brentano parafocusing geometry

    NARCIS (Netherlands)

    Van der Pers, N.M.; Hendrikx, R.W.A.; Delhez, R.; Böttger, A.J.

    2013-01-01

    A new diffracted-beam monochromator has been developed for Bragg-Brentano X-ray diffractometers equipped with a linear detector. The monochromator consists of a cone-shaped graphite highly oriented pyrolytic graphite crystal oriented out of the equatorial plane such that the parafocusing geometry is

  19. A simulation-based study on the influence of beam hardening in X-ray computed tomography for dimensional metrology.

    Science.gov (United States)

    Lifton, Joseph J; Malcolm, Andrew A; McBride, John W

    2015-01-01

    X-ray computed tomography (CT) is a radiographic scanning technique for visualising cross-sectional images of an object non-destructively. From these cross-sectional images it is possible to evaluate internal dimensional features of a workpiece which may otherwise be inaccessible to tactile and optical instruments. Beam hardening is a physical process that degrades the quality of CT images and has previously been suggested to influence dimensional measurements. Using a validated simulation tool, the influence of spectrum pre-filtration and beam hardening correction are evaluated for internal and external dimensional measurements. Beam hardening is shown to influence internal and external dimensions in opposition, and to have a greater influence on outer dimensions compared to inner dimensions. The results suggest the combination of spectrum pre-filtration and a local gradient-based surface determination method are able to greatly reduce the influence of beam hardening in X-ray CT for dimensional metrology.

  20. Design and performance of coded aperture optical elements for the CESR-TA x-ray beam size monitor

    Science.gov (United States)

    Alexander, J. P.; Chatterjee, A.; Conolly, C.; Edwards, E.; Ehrlichman, M. P.; Flanagan, J. W.; Fontes, E.; Heltsley, B. K.; Lyndaker, A.; Peterson, D. P.; Rider, N. T.; Rubin, D. L.; Seeley, R.; Shanks, J.

    2014-12-01

    We describe the design and performance of optical elements for an x-ray beam size monitor (xBSM), a device measuring e+ and e- beam sizes in the CESR-TA storage ring. The device can measure vertical beam sizes of 10 - 100 μm on a turn-by-turn, bunch-by-bunch basis at e± beam energies of ~ 2 - 5 GeV. x-rays produced by a hard-bend magnet pass through a single- or multiple-slit (coded aperture) optical element onto a detector. The coded aperture slit pattern and thickness of masking material forming that pattern can both be tuned for optimal resolving power. We describe several such optical elements and show how well predictions of simple models track measured performances.

  1. Design and performance of coded aperture optical elements for the CESR-TA x-ray beam size monitor

    CERN Document Server

    Alexander, J P; Conolly, C; Edwards, E; Ehrlichman, M P; Flanagan, J W; Fontes, E; Heltsley, B K; Lyndaker, A; Peterson, D P; Rider, N T; Rubin, D L; Seeley, R; Shanks, J

    2014-01-01

    We describe the design and performance of optical elements for an x-ray beam size monitor (xBSM), a device measuring $e^+$ and $e^-$ beam sizes in the CESR-TA storage ring. The device can measure vertical beam sizes of $10-100~\\mu$m on a turn-by-turn, bunch-by-bunch basis at $e^\\pm$ beam energies of $\\sim2-5~$GeV. X-rays produced by a hard-bend magnet pass through a single- or multiple-slit (coded aperture) optical element onto a detector. The coded aperture slit pattern and thickness of masking material forming that pattern can both be tuned for optimal resolving power. We describe several such optical elements and show how well predictions of simple models track measured performances.

  2. Application of Small Angle X-ray Scattering (SAXS for Differentiation between Normal and Cancerous Breast Tissue

    Directory of Open Access Journals (Sweden)

    2005-07-01

    Full Text Available Introduction: Small angle, between 3° and 10°, X ray scattering is predominantly coherent giving rise to diffraction effects that can be observed as constructive and destructive interferences. These interferences carry information about the molecular structure of the tissue and hence can be used to identify changes that occur due to cancer. Method: In this study an energy dispersive X-ray diffraction method was used. The optimum scattering angle, determined from a series of measurements on adipose breast tissue at several angles from 4 to 7.3 degrees, was found to be 6.5°. Once optimized the system was used to measure the diffraction profiles (corrected scattered intensity versus momentum transfer of a total of 99 breast tissue samples. The samples were both normal and tumour samples. Results: Adipose tissue showed a sharp, high intensity peak at low momentum transfer values of approximately 1.1nm-1. Adipose tissue, mixed tissue (adipose & fibroglandular and tumor have peaks at different values of momentum transfer that can be used to identify the tissue. Benign and malignant breast tissues can also be differentiated by both peak positions and peak heights. It was also observed that the results were reproducible even after the tissue had been preserved at liquid nitrogen temperatures. Conclusion: We were able to differentiate between normal, benign and malignant breast tissues by using energy dispersive small angle x-ray scattering.

  3. Thermal management and prototype testing of Compton scattering X-ray beam position monitor for the Advanced Photon Source Upgrade

    Science.gov (United States)

    Lee, S. H.; Yang, B. X.; Collins, J. T.; Ramanathan, M.

    2017-02-01

    Accurate and stable x-ray beam position monitors (XBPMs) are key elements in obtaining the desired user beam stability in the Advanced Photon Source Upgrade. In the next-generation XBPMs for the canted-undulator front ends, where two undulator beams are separated by 1.0 mrad, the lower beam power (cost solutions based on Compton scattering from a diamond placed edge-on to the x-ray beam. Because of the high peak power density of the x-ray beams, this diamond experiences high temperatures and has to be clamped to a water-cooled heat spreader using thermal interface materials (TIMs), which play a key role in reducing the temperature of the diamond. To evaluate temperature changes through the interface via thermal simulations, the thermal contact resistance (TCR) of TIMs at an interface between two solid materials under even contact pressure must be known. This paper addresses the TCR measurements of several TIMs, including gold, silver, pyrolytic graphite sheet, and 3D graphene foam. In addition, a prototype of a Compton-scattering XBPM with diamond blades was installed at APS Beamline 24-ID-A in May 2015 and has been tested. This paper presents the design of the Compton-scattering XBPM, and compares thermal simulation results obtained for the diamond blade of this XBPM by the finite element method with in situ empirical measurements obtained by using reliable infrared technology.

  4. Experimental assessment of the influence of beam hardening filters on image quality and patient dose in volumetric 64-slice X-ray CT scanners

    NARCIS (Netherlands)

    Ay, Mohammad Reza; Mehranian, Abolfazi; Maleki, Asghar; Ghadiri, Hossien; Ghafarian, Pardis; Zaidi, Habib

    2013-01-01

    Beam hardening filters have long been employed in X-ray Computed Tomography (CT) to preferentially absorb soft and low-energy X-rays having no or little contribution to image formation, thus allowing the reduction of patient dose and beam hardening artefacts. In this work, we studied the influence o

  5. Soft x-ray generation in gases by means of a pulsed electron beam produced in a high-voltage barier discharge

    NARCIS (Netherlands)

    Azarov, A.V.; Peters, P.J.M.; Boller, K.-J.

    2007-01-01

    A large area pulsed electron beam is produced by a high-voltage barrier discharge. We compare the properties of the x-rays generated by stopping this beam of electrons in a thin metal foil with those generated by stopping the electrons directly in various gases. The generation of x-rays was investig

  6. Characterizing X-ray detectors for prototype digital breast tomosynthesis systems

    Science.gov (United States)

    Kim, Y.-s.; Park, H.-s.; Park, S.-J.; Choi, S.; Lee, H.; Lee, D.; Choi, Y.-W.; Kim, H.-J.

    2016-03-01

    The digital breast tomosynthesis (DBT) system is a newly developed 3-D imaging technique that overcomes the tissue superposition problems of conventional mammography. Therefore, it produces fewer false positives. In DBT system, several parameters are involved in image acquisition, including geometric components. A series of projections should be acquired at low exposure. This makes the system strongly dependent on the detector's characteristic performance. This study compares two types of x-ray detectors developed by the Korea Electrotechnology Research Institute (KERI). The first prototype DBT system has a CsI (Tl) scintillator/CMOS based flat panel digital detector (2923 MAM, Dexela Ltd.), with a pixel size of 0.0748 mm. The second uses a-Se based direct conversion full field detector (AXS 2430, analogic) with a pixel size of 0.085 mm. The geometry of both systems is same, with a focal spot 665.8 mm from the detector, and a center of rotation 33 mm above the detector surface. The systems were compared with regard to modulation transfer function (MTF), normalized noise power spectrum (NNPS), detective quantum efficiency (DQE) and a new metric, the relative object detectability (ROD). The ROD quantifies the relative performance of each detector at detecting specified objects. The system response function demonstrated excellent linearity (R2>0.99). The CMOS-based detector had a high sensitivity, while the Anrad detector had a large dynamic range. The higher MTF and noise power spectrum (NPS) values were measured using an Anrad detector. The maximum DQE value of the Dexela detector was higher than that of the Anrad detector with a low exposure level, considering one projection exposure for tomosynthesis. Overall, the Dexela detector performed better than did the Anrad detector with regard to the simulated Al wires, spheres, test objects of ROD with low exposure level. In this study, we compared the newly developed prototype DBT system with two different types of x-ray

  7. All-diamond optical assemblies for a beam-multiplexing X-ray monochromator at the Linac Coherent Light Source

    CERN Document Server

    Stoupin, S; Blank, V D; Shvyd'ko, Yu V; Goetze, K; Assoufid, L; Polyakov, S N; Kuznetsov, M S; Kornilov, N V; Katsoudas, J; Alonso-Mori, R; Chollet, M; Feng, Y; Glownia, J M; Lemke, H; Robert, A; Song, S; Sikorski, M; Zhu, D

    2014-01-01

    A double-crystal diamond (111) monochromator recently implemented at the Linac Coherent Light Source (LCLS) enables splitting of the primary X-ray beam into a pink (transmitted) and a monochromatic (reflected) branch. The first monochromator crystal with a thickness of 100 um provides sufficient X-ray transmittance to enable simultaneous operation of two beamlines. Here we report on the design, fabrication, and X-ray characterization of the first and second (300-um-thick) crystals utilized in the monochromator and the optical assemblies holding these crystals. Each crystal plate has a region of about 5 X 2 mm2 with low defect concentration, sufficient for use in X-ray optics at the LCLS. The optical assemblies holding the crystals were designed to provide mounting on a rigid substrate and to minimize mounting-induced crystal strain. The induced strain was evaluated using double-crystal X-ray topography and was found to be small over the 5 X 2 mm2 working regions of the crystals.

  8. Applications of pixellated GaAs X-ray detectors in a synchrotron radiation beam

    CERN Document Server

    Watt, J; Campbell, M; Mathieson, K; Mikulec, B; O'Shea, V; Passmore, M S; Schwarz, C; Smith, K M; Whitehill, C

    2001-01-01

    Hybrid semiconductor pixel detectors are being investigated as imaging devices for radiography and synchrotron radiation beam applications. Based on previous work in the CERN RD19 and the UK IMPACT collaborations, a photon counting GaAs pixel detector (PCD) has been used in an X-ray powder diffraction experiment. The device consists of a 200 mu m thick SI-LEC GaAs detector patterned in a 64*64 array of 170 mu m pitch square pixels, bump-bonded to readout electronics operating in single photon counting mode. Intensity peaks in the powder diffraction pattern of KNbO/sub 3/ have been resolved and compared with results using the standard scintillator, and a PCD predecessor (the Omega 3). The PCD shows improved speed, dynamic range, 2-D information and comparable spatial resolution to the standard scintillator based systems. It also overcomes the severe dead time limitations of the Omega 3 by using a shutter based acquisition mode. A brief demonstration of the possibilities of the system for dental radiography and...

  9. Applications of pixellated GaAs X-ray detectors in a synchrotron radiation beam

    Energy Technology Data Exchange (ETDEWEB)

    Watt, J. E-mail: j.watt@physics.gla.ac.uk; Bates, R.; Campbell, M.; Mathieson, K.; Mikulec, B.; O' Shea, V.; Passmore, M-S.; Schwarz, C.; Smith, K.M.; Whitehill, C

    2001-03-11

    Hybrid semiconductor pixel detectors are being investigated as imaging devices for radiography and synchrotron radiation beam applications. Based on previous work in the CERN RD19 and the UK IMPACT collaborations, a photon counting GaAs pixel detector (PCD) has been used in an X-ray powder diffraction experiment. The device consists of a 200 {mu}m thick SI-LEC GaAs detector patterned in a 64x64 array of 170 {mu}m pitch square pixels, bump-bonded to readout electronics operating in single photon counting mode. Intensity peaks in the powder diffraction pattern of KNbO{sub 3} have been resolved and compared with results using the standard scintillator, and a PCD predecessor (the {omega}3). The PCD shows improved speed, dynamic range, 2-D information and comparable spatial resolution to the standard scintillator based systems. It also overcomes the severe dead time limitations of the {omega}3 by using a shutter based acquisition mode. A brief demonstration of the possibilities of the system for dental radiography and image processing are given, showing a marked reduction in patient dose and dead time compared with film.

  10. Characterization of coplanar grid CZT detectors with highly collimated x-ray beam

    Science.gov (United States)

    Carini, Gabriella A.; Bolotnikov, Aleksey E.; Camarda, Giuseppe S.; Wright, Gomez W.; De Geronimo, Gianluigi; Siddons, D. P.; James, Ralph B.

    2004-10-01

    CdZnTe detectors demonstrated great potentials for detection of gamma radiation. However, energy resolution of CdZnTe detectors is significantly affected by uncollected holes which have low mobility and short lifetime. To overcome this deleterious effects upon energy resolution special detector designs have to be implemented. The most practical of them are the small pixel effect device, the co-planar grid device, and the virtual Frisch-grid device. We routinely use a highly collimated high-intensity X-ray beams provided by National Synchrotron Light Source (NSLS) facility at Brookhaven National Laboratory to study of CdZnTe material and performances of the different types of devices on the micron-scale. This powerful tool allows us to evaluate electronic properties of the material, device performance, uniformity of the detector responses, effects related to the device's contact pattern and electric field distribution, etc. In particular, in this paper we present new results obtained from the performance studies of 15 x 15 x 7.5 mm3 coplanar-grid devices coupled to readout ASIC. We observed the effect of the strip contacts comprising the grids on the energy resolution of the coplanar-grid device.

  11. X-ray attenuation of adipose breast tissue: in-vitro and in-vivo measurements using spectral imaging

    Science.gov (United States)

    Fredenberg, Erik; Erhard, Klaus; Berggren, Karl; Dance, David R.; Young, Kenneth C.; Cederström, Björn; Johansson, Henrik; Lundqvist, Mats; Moa, Elin; Homan, Hanno; Willsher, Paula; Kilburn-Toppin, Fleur; Wallis, Matthew

    2015-03-01

    The development of new x-ray imaging techniques often requires prior knowledge of tissue attenuation, but the sources of such information are sparse. We have measured the attenuation of adipose breast tissue using spectral imaging, in vitro and in vivo. For the in-vitro measurement, fixed samples of adipose breast tissue were imaged on a spectral mammography system, and the energy-dependent x-ray attenuation was measured in terms of equivalent thicknesses of aluminum and poly-methyl methacrylate (PMMA). For the in-vivo measurement, a similar procedure was applied on a number of spectral screening mammograms. The results of the two measurements agreed well and were consistent with published attenuation data and with measurements on tissue-equivalent material.

  12. High-Flux Femtosecond X-Ray Emission from Controlled Generation of Annular Electron Beams in a Laser Wakefield Accelerator.

    Science.gov (United States)

    Zhao, T Z; Behm, K; Dong, C F; Davoine, X; Kalmykov, S Y; Petrov, V; Chvykov, V; Cummings, P; Hou, B; Maksimchuk, A; Nees, J A; Yanovsky, V; Thomas, A G R; Krushelnick, K

    2016-08-26

    Annular quasimonoenergetic electron beams with a mean energy in the range 200-400 MeV and charge on the order of several picocoulombs were generated in a laser wakefield accelerator and subsequently accelerated using a plasma afterburner in a two-stage gas cell. Generation of these beams is associated with injection occurring on the density down ramp between the stages. This well-localized injection produces a bunch of electrons performing coherent betatron oscillations in the wakefield, resulting in a significant increase in the x-ray yield. Annular electron distributions are detected in 40% of shots under optimal conditions. Simultaneous control of the pulse duration and frequency chirp enables optimization of both the energy and the energy spread of the annular beam and boosts the radiant energy per unit charge by almost an order of magnitude. These well-defined annular distributions of electrons are a promising source of high-brightness laser plasma-based x rays.

  13. Nano-modulated electron beams via electron diffraction and emittance exchange for coherent x-ray generation

    CERN Document Server

    Nanni, Emilio A; Moncton, David E

    2015-01-01

    A new method for generation of relativistic electron beams with current modulations at nanometer scale and below is presented. The current modulation is produced by diffracting relativistic electrons in perfect crystal Si, accelerating the diffracted beam and imaging the crystal structure, then transferring the image into the temporal dimension via emittance exchange. The modulation period can be tuned by adjusting electron optics after diffraction. This tunable longitudinal modulation can have a period as short as a few angstroms, enabling production of coherent hard x-rays from a device based on inverse Compton scattering with total length of a few meters. Electron beam simulations from cathode emission through diffraction, acceleration and image formation with variable magnification are presented along with estimates of the coherent x-ray output properties.

  14. X-ray tube-based diffraction enhanced imaging prototype images of full-thickness breast specimens: reader study evaluation

    Science.gov (United States)

    Faulconer, L. S.; Parham, C.; Connor, D. J.; Koomen, M.; Kuzmiak, C.; Pavic, D.; Livasy, C. A.; Kim, E.; Zeng, D.; Cole, E. B.; Zhong, Z.; Pisano, E. D.

    2009-02-01

    Conventional mammographic image contrast is derived from x-ray absorption, resulting in breast structure visualization due to density gradients that attenuate radiation without distinction between transmitted and scattered or refracted x-rays. This leads to image blurring and contrast reduction, hindering the early detection of small or otherwise occult cancers. Diffraction enhanced imaging (DEI) allows for dramatically increased contrast with decreased radiation dose compared to conventional mammographic imaging due to monochromatic x-rays, its unique refraction-based contrast mechanism and excellent scatter rejection. However, a lingering drawback to the clinical translation of DEI has been the requirement for synchrotron radiation. Our laboratory developed a DEI prototype (DEI-PR) utilizing a readily available Tungsten xray tube source and traditional DEI crystal optics, providing soft tissue images at 60keV. To demonstrate the clinical utility of our DEI-PR, we acquired images of full-thickness human breast tissue specimens on synchrotron-based DEI, DEI-PR and digital mammography systems. A reader study was designed to allow unbiased assessment of system performance when analyzing three systems with dissimilar imaging parameters and requiring analysis of images unfamiliar to radiologists. A panel of expert radiologists evaluated lesion feature visibility and histopathology correlation after receiving training on the interpretation of refraction contrast mammographic images. Preliminary data analysis suggests that our DEI system performed roughly equivalently with the traditional DEI system, demonstrating a significant step toward clinical translation of this modality for breast cancer applications.

  15. X-ray Diagnosis of Breast Cancer%乳腺癌的X线诊断分析

    Institute of Scientific and Technical Information of China (English)

    王涛

    2015-01-01

    Objective To investigate the X-ray diagnosis of breast cancer patients analyzed. Methods A retrospective analysis of X-ray ifndings of our hospital in 2012 and 2014 were treated 22 cases of breastcancer patients. Results The performance of breast lumps shadow, tumor calcification, nipple retraction, skin thickening, thickening of the vein. Conclusion X-ray examination is the main diagnostic tool in breast cancer.%目的 探讨乳腺癌患者的X线诊断分析.方法回顾性分析我院2012年~2014年收治的22例乳腺癌患者的X线表现.结果 乳腺癌的表现为肿块阴影、肿瘤钙化、乳头凹陷、皮肤增厚、静脉增粗.结论 X线平片是检查乳腺癌主要诊断手段.

  16. Imaging crystal spectrometer for high-resolution x-ray measurements on electron beam ion traps and tokamaks

    Science.gov (United States)

    Beiersdorfer, P.; Magee, E. W.; Hell, N.; Brown, G. V.

    2016-11-01

    We describe a crystal spectrometer implemented on the Livermore electron beam ion traps that employ two spherically bent quartz crystals and a cryogenically cooled back-illuminated charge-coupled device detector to measure x rays with a nominal resolving power of λ/Δλ ≥ 10 000. Its focusing properties allow us to record x rays either with the plane of dispersion perpendicular or parallel to the electron beam and, thus, to preferentially select one of the two linear x-ray polarization components. Moreover, by choice of dispersion plane and focussing conditions, we use the instrument either to image the distribution of the ions within the 2 cm long trap region, or to concentrate x rays of a given energy to a point on the detector, which optimizes the signal-to-noise ratio. We demonstrate the operation and utility of the new instrument by presenting spectra of Mo34+, which prepares the instrument for use as a core impurity diagnostic on the NSTX-U spherical torus and other magnetic fusion devices that employ molybdenum as plasma facing components.

  17. Instrumentation developments for production and characterisation of Inverse Compton Scattering X-rays and first results with a 17 MeV electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Chauchat, A.S., E-mail: anne-sophie.chauchat@cea.f [CEA, DAM, DIF, F-91297 Arpajon (France); Le Flanchec, V.; Negre, J.P.; Binet, A.; Balleyguier, P. [CEA, DAM, DIF, F-91297 Arpajon (France); Brasile, J.P. [THALES Communication, 160 Bd de Valmy, F-92700 Colombes (France); Ortega, J.M. [CLIO/LCP, Batiment 201, Universite Paris-Sud, F-91405 Orsay (France)

    2010-10-01

    An X-ray Compton source is under development at the ELSA facility. The electron beam coming from the ELSA linear accelerator interacts with a laser beam to generate an X-ray flux in the direction of the electron beam. With a 17 MeV electron beam and a 532 nm laser, the resulting X-ray maximal energy is around 11 keV. The beams visualization at the interaction point is achieved via an aluminum retractable bevel-edge with an OTR surface on one side and a slightly roughened surface on the other. Thanks to an optical beamsplitter, beam images are both transmitted to a CCD camera and to a streak camera to manage the spatial and temporal overlap of the bunches. Careful beam management and electron background noise minimization were both required to observe the first Inverse Compton Scattering X-ray profile of this source on radio-luminescent imaging plates.

  18. Quality indexes based on water measurements for low and medium energy x-ray beams: A theoretical study with PENELOPE

    Energy Technology Data Exchange (ETDEWEB)

    Chica, U. [Departamento de Física Atómica, Molecular y Nuclear, Universidad de Granada, E-18071 Granada, Spain and FISRAD S.A.S Carrera 64 a No 22-41, Bogotá D.C. (Colombia); Anguiano, M.; Lallena, A. M., E-mail: lallena@ugr.es [Departamento de Física Atómica, Molecular y Nuclear, Universidad de Granada, E-18071 Granada (Spain); Vilches, M. [Servicio de Radiofísica, Hospital Universitario “San Cecilio”, Avda. Dr. Olóriz, 16, E-18012 Granada (Spain)

    2014-01-15

    Purpose : To study the use of quality indexes based on ratios of absorbed doses in water at two different depths to characterize x-ray beams of low and medium energies. Methods : A total of 55 x-ray beam spectra were generated with the codes XCOMP5R and SPEKCALC and used as input of a series of Monte Carlo simulations performed with PENELOPE, in which the percentage depth doses in water and thek{sub Q,Q{sub 0}} factors, defined in the TRS-398 protocol, were determined for each beam. Some of these calculations were performed by simulating the ionization chamber PTW 30010. Results : The authors found that the relation betweenk{sub Q,Q{sub 0}} and the ratios of absorbed doses at two depths is almost linear. A set of ratios statistically compatible with that showing the best fit has been determined. Conclusions : The results of this study point out which of these ratios of absorbed doses in water could be used to better characterize x-ray beams of low and medium energies.

  19. Measurement of breast-tissue x-ray attenuation by spectral mammography: first results on cyst fluid

    Science.gov (United States)

    Fredenberg, Erik; Dance, David R.; Willsher, Paula; Moa, Elin; von Tiedemann, Miriam; Young, Kenneth C.; Wallis, Matthew G.

    2013-12-01

    Knowledge of x-ray attenuation is essential for developing and evaluating x-ray imaging technologies. For instance, techniques to better characterize cysts at mammography screening would be highly desirable to reduce recalls, but the development is hampered by the lack of attenuation data for cysts. We have developed a method to measure x-ray attenuation of tissue samples using a prototype photon-counting spectral mammography unit. The method was applied to measure the attenuation of 50 samples of breast cyst fluid and 50 samples of water. Spectral (energy-resolved) images of the samples were acquired and the image signal was mapped to equivalent thicknesses of two known reference materials, which can be used to derive the x-ray attenuation as a function of energy. The attenuation of cyst fluid was found to be significantly different from water. There was a relatively large natural spread between different samples of cyst fluid, whereas the homogeneity of each individual sample was found to be good; the variation within samples did not reach above the quantum noise floor. The spectral method proved stable between several measurements on the same sample. Further, chemical analysis and elemental attenuation calculation were used to validate the spectral measurement on a subset of the samples. The two methods agreed within the precision of the elemental attenuation calculation over the mammographic energy range.

  20. Three-dimensional manipulation of electron beam phase space for seeding soft x-ray free-electron lasers

    CERN Document Server

    Feng, Chao; Deng, Haixiao; Zhao, Zhentang

    2014-01-01

    In this letter, a simple technique is proposed to induce strong density modulation into the electron beam with small energy modulation. By using the combination of a transversely dispersed electron beam and a wave-front tilted seed laser, three-dimensional manipulation of the electron beam phase space can be utilized to significantly enhance the micro-bunching of seeded free-electron laser schemes, which will improve the performance and extend the short-wavelength range of a single-stage seeded free-electron laser. Theoretical analysis and numerical simulations demonstrate the capability of the proposed technique in a soft x-ray free-electron laser.

  1. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... patient. top of page How does the procedure work? X-rays are a form of radiation like ... very controlled x-ray beams and dose control methods to minimize stray (scatter) radiation. This ensures that ...

  2. 3D algebraic iterative reconstruction for cone-beam x-ray differential phase-contrast computed tomography.

    Science.gov (United States)

    Fu, Jian; Hu, Xinhua; Velroyen, Astrid; Bech, Martin; Jiang, Ming; Pfeiffer, Franz

    2015-01-01

    Due to the potential of compact imaging systems with magnified spatial resolution and contrast, cone-beam x-ray differential phase-contrast computed tomography (DPC-CT) has attracted significant interest. The current proposed FDK reconstruction algorithm with the Hilbert imaginary filter will induce severe cone-beam artifacts when the cone-beam angle becomes large. In this paper, we propose an algebraic iterative reconstruction (AIR) method for cone-beam DPC-CT and report its experiment results. This approach considers the reconstruction process as the optimization of a discrete representation of the object function to satisfy a system of equations that describes the cone-beam DPC-CT imaging modality. Unlike the conventional iterative algorithms for absorption-based CT, it involves the derivative operation to the forward projections of the reconstructed intermediate image to take into account the differential nature of the DPC projections. This method is based on the algebraic reconstruction technique, reconstructs the image ray by ray, and is expected to provide better derivative estimates in iterations. This work comprises a numerical study of the algorithm and its experimental verification using a dataset measured with a three-grating interferometer and a mini-focus x-ray tube source. It is shown that the proposed method can reduce the cone-beam artifacts and performs better than FDK under large cone-beam angles. This algorithm is of interest for future cone-beam DPC-CT applications.

  3. Novel correction method for X-ray beam energy fluctuation of high energy DR system with a linear detector

    Institute of Scientific and Technical Information of China (English)

    YANG Min; CHEN Hao; MENG Fan-Yong; WEI Dong-Bo

    2011-01-01

    A high energy digital radiography (DR) testing system has generated diverse scientific and technological interest in the field of industrial non-destructive testing.However,due to the limitations of manufacturing technology for accelerators,an energy fluctuation of the X-ray beam exists and leads to bright and dark streak artifacts in the DR image.Here we report the utilization of a new software-based method to correct the fluctuation artifacts.The correction method is performed using a high pass filtering operation to extract the high frequency information that reflects the X-ray beam energy fluctuation,and then subtracting it from the original image.Our experimental results show that this method is able to rule out the artifacts effectively and is readily implemented on a practical scanning system.

  4. Evaluation of some selected vaccines and other biological products irradiated by gamma rays, electron beams and X-rays

    Science.gov (United States)

    May, J. C.; Rey, L.; Lee, Chi-Jen

    2002-03-01

    Molecular sizing potency results are presented for irradiated samples of one lot of Haemophilus b conjugate vaccine, pneumococcal polysaccharide type 6B and typhoid vi polysaccharide vaccine. The samples were irradiated (25 kGy) by gamma rays, electron beams and X-rays. IgG and IgM antibody response in mice test results (ELISA) are given for the Hib conjugate vaccine irradiated at 0°C or frozen in liquid nitrogen.

  5. Evaluation of some selected vaccines and other biological products irradiated by gamma rays, electron beams and X-rays

    Energy Technology Data Exchange (ETDEWEB)

    May, J.C. E-mail: may@cber.fda.gov; Rey, L.; Lee, C.-J

    2002-03-01

    Molecular sizing potency results are presented for irradiated samples of one lot of Haemophilus b conjugate vaccine, pneumococcal polysaccharide type 6B and typhoid vi polysaccharide vaccine. The samples were irradiated (25 kGy) by gamma rays, electron beams and X-rays. IgG and IgM antibody response in mice test results (ELISA) are given for the Hib conjugate vaccine irradiated at 0 deg. C or frozen in liquid nitrogen.

  6. An experiment of X-ray photon–photon elastic scattering with a Laue-case beam collider

    Directory of Open Access Journals (Sweden)

    T. Yamaji

    2016-12-01

    Full Text Available We report a search for photon–photon elastic scattering in vacuum in the X-ray region at an energy in the center of mass system of ωcms=6.5keV for which the QED cross section is σQED=2.5×10−47m2. An X-ray beam provided by the SACLA X-ray Free Electron Laser is split and the two beamlets are made to collide at right angle, with a total integrated luminosity of (1.24±0.08×1028m−2. No signal X rays from the elastic scattering that satisfy the correlation between energy and scattering angle were detected. We obtain a 95% C.L. upper limit for the scattering cross section of 1.9×10−27m2 at ωcms=6.5keV. The upper limit is the lowest upper limit obtained so far by keV experiments.

  7. X-ray Radiation Mechanisms and the Beaming Effect of Hot Spots and Knots in AGN Jets

    Indian Academy of Sciences (India)

    Jin Zhang; Jin-Ming Bai; Liang Chen; Enwei Liang

    2011-03-01

    The observed broadband spectral energy distributions (SEDs) of 22 hot spots and 45 knots are modelled with single-zone lepton models. Considering the sources at rest, the X-rays of some hot spots can be explained by the SSC model with magnetic field being consistent with the equipartition magnetic field in magnitude of order 1, but at the same time an unreasonably low magnetic field is required to model the X-rays for all knots. When considering the relativistic bulk motion of the sources, the IC/CMB model well explains the X-ray emission for most of them under the equipartition condition. We show that the ratio of observational luminosity is tentatively correlated with the co-moving equipartition magnetic field 'eq and the beaming factor . These facts suggest that the observational differences of the X-rays from the knots and hot spots may be mainly due to the differences in the Doppler boosting effect and the co-moving magnetic field of the two kinds of source.

  8. X-ray diffraction imaging with the Multiple Inverse Fan Beam topology: principles, performance and potential for security screening.

    Science.gov (United States)

    Harding, G; Fleckenstein, H; Kosciesza, D; Olesinski, S; Strecker, H; Theedt, T; Zienert, G

    2012-07-01

    The steadily increasing number of explosive threat classes, including home-made explosives (HMEs), liquids, amorphous and gels (LAGs), is forcing up the false-alarm rates of security screening equipment. This development can best be countered by increasing the number of features available for classification. X-ray diffraction intrinsically offers multiple features for both solid and LAGs explosive detection, and is thus becoming increasingly important for false-alarm and cost reduction in both carry-on and checked baggage security screening. Following a brief introduction to X-ray diffraction imaging (XDI), which synthesizes in a single modality the image-forming and material-analysis capabilities of X-rays, the Multiple Inverse Fan Beam (MIFB) XDI topology is described. Physical relationships obtaining in such MIFB XDI components as the radiation source, collimators and room-temperature detectors are presented with experimental performances that have been achieved. Representative X-ray diffraction profiles of threat substances measured with a laboratory MIFB XDI system are displayed. The performance of Next-Generation (MIFB) XDI relative to that of the 2nd Generation XRD 3500TM screener (Morpho Detection Germany GmbH) is assessed. The potential of MIFB XDI, both for reducing the exorbitant cost of false alarms in hold baggage screening (HBS), as well as for combining "in situ" liquid and solid explosive detection in carry-on luggage screening is outlined.

  9. Comparison of Quality of Bologna Sausage Manufactured by Electron Beam or X-Ray Irradiated Ground Pork.

    Science.gov (United States)

    Shin, Mee-Hye; Lee, Ju-Woon; Yoon, Young-Min; Kim, Jong Heon; Moon, Byeong-Geum; Kim, Jae-Hun; Song, Beom-Suk

    2014-01-01

    Ground lean pork was irradiated by an electron beam or X-rays to compare the effects of two types of radiation generated by a linear accelerator on the quality of Bologna sausage as a model meat product. Raw ground lean pork was vacuum packaged at a thickness of 1.5 cm and irradiated at doses of 2, 4, 6, 8, or 10 kGy by an electron beam (2.5 MeV) or X-rays (5 MeV). Solubility of myofibrillar proteins, bacterial counts, and thiobarbituric acid reactive substance (TBARS) values were determined for raw meat samples. Bologna sausage was manufactured using the irradiated lean pork, and total bacterial counts, TBARS values, and quality properties (color differences, cooking yield, texture, and palatability) were determined. Irradiation increased the solubility of myofibrillar proteins in a dose-dependent manner (p<0.05). Bacterial contamination of the raw meat was reduced as the absorbed dose increased, and the reduction was the same for both radiation types. Differences were observed only between irradiated and non-irradiated samples (p<0.05). X-ray irradiation may serve as an alternative to gamma irradiation and electron beam irradiation.

  10. Multi-concentric-ring open-air ionization chamber for high-intensity X-ray beams

    Science.gov (United States)

    Nariyama, Nobuteru

    2014-11-01

    An ionization chamber with four concentric ring electrodes was used to measure doses of white, 10, 15 and 20 keV synchrotron X-ray beams. The ring-shaped electrodes, which had diameters less than 11.8 mm, collected charges independently only around the beam, excluding strong in-beam charges when the beams passed through a small hole in the electrode centers. As a result, under low saturation voltages, the measured dose rates were confirmed to correlate with the beam intensity when conversion factors calculated with a Monte Carlo code were employed. The influence of the assumed beam sizes and incident positions on the current was almost negligible, with the exception of the incident position dependence at 10 keV.

  11. X-ray beam source from a Self-modulated laser wakefield accelerator

    Science.gov (United States)

    Lemos, Nuno; Albert, Felicie; Marsh, K. A.; Shaw, J. L.; King, P.; Patankar, S.; Ralph, J.; Pollock, B. B.; Martins, J. L.; Amorim, L. D.; Tsung, F. S.; Goyon, C.; Pak, A.; Moody, J. D.; Schumaker, W.; Fiuza, F.; Glenzer, S. H.; Hegelichand, B. M.; Saunders, A.; Flacone, R. W.; Joshi, C.

    2016-10-01

    To diagnose material properties under extreme conditions of temperature and pressure the development of a directional, small-divergence, small source size and short pulse duration x-ray source has become essential. In this work we explore through experiments and PIC simulations the betatron radiation generated in self-modulated laser-wakefield accelerators. The experiment was preformed at the Jupiter Laser Facility, LLNL where electrons with energies up to 200 MeV and Betatron x-rays with critical energies >10 keV were observed. OSIRIS 2D PIC simulations indicate that the x-ray critical energy directly scales with the a0 of the laser and can easily be increased to critical energies exceeding 50 keV using a laser with a0 of 3.

  12. X-ray monitoring optical elements

    Energy Technology Data Exchange (ETDEWEB)

    Stoupin, Stanislav; Shvydko, Yury; Katsoudas, John; Blank, Vladimir D.; Terentyev, Sergey A.

    2016-12-27

    An X-ray article and method for analyzing hard X-rays which have interacted with a test system. The X-ray article is operative to diffract or otherwise process X-rays from an input X-ray beam which have interacted with the test system and at the same time provide an electrical circuit adapted to collect photoelectrons emitted from an X-ray optical element of the X-ray article to analyze features of the test system.

  13. Heavy Ion Beams Induce Survivin Expression in Human Hepatoma SMMC-7721 Cells More Effectively than X-rays

    Institute of Scientific and Technical Information of China (English)

    Li GONG; Xiaodong JIN; Qiang LI; Jiangtao LIU; Lizhe AN

    2007-01-01

    High linear energy transfer (LET) heavy ion radiation is more effective in inducing biological damage than low-LET X-rays or γ-rays. Heavy ion beam provides good dose localization (Bragg peak) in critical cancer tissue and gives higher relative biological effectiveness in cell killing across the dose peak, so high-LET heavy ion beam is superior to low-LET radiation in cancer treatment. Survivin, as a member of the inhibitor of apoptosis protein family, might help cancerous cells to overcome the G2/M apoptotic checkpoint and favor the aberrant progression of transformed cells through mitosis. Survivin expression in the human hepatoma SMMC-7721 cell line after exposure to low-LET X-ray and high-LET carbon ion irradiation was investigated in this study. Compared with X-ray irradiation, the carbon ion beam clearly caused G2/M arrest and promoted the expression of the survivin gene in a dose-dependent manner. Clonogenic survival assay showed that SMMC-7721 cells were more radiosensitive to the high-LET carbon ions than to the X-rays, and the radiosensitivity was promoted after treatment with specific survivin short interfering RNA. Differential survivin expression at both transcriptional and translational levels was found for SMMC-7721 cells following low- and high-LET irradiation. The overexpression of survivin in SMMC-7721 cells is probably an important reason why the cancerous cells have radioresistance to strong stimulus such as dense ionizing high-LET radiation. However, the direct killing effect on cancerous cells by high-LET radiation might be more significant than the apoptosis inhibition through the overexpression of survivin following heavy ion irradiation.

  14. Soft X-Ray (1-7 nm) Solar Spectrometer based on novel Nanowriter Electron-Beam Nanofabrication Technology

    Science.gov (United States)

    Didkovsky, L. V.; Wieman, S. R.; Chao, W.

    2015-12-01

    A new soft X-ray (SXR) spectrometer combines proven detector technology demonstrated on the SOHO Solar EUV Monitor (SOHO/SEM) and SDO EUV SpectroPhotometer (SDO/EVE/ESP) instruments with novel technology for X-ray optics nanofabrication developed at the Lawrence Berkeley National Laboratory. The new spectrometer will provide solar SXR measurements of absolute irradiance in the 1.0 to 7.0 nm range spectrally resolved into bands narrower than 1 nm - measurements that are not available from existing solar-observing instruments but are important for studying and modeling coronal dynamics and the Sun-Earth's connection, e.g. the Earth's Ionosphere. For the proposed SXR spectrometer we will introduce a transmission grating based on novel Nanowriter Electron-Beam Nanofabrication technology developed at the Center for X-ray Optics (CXRO) at the Lawrence Berkeley National Laboratory. The CXRO technology has been used in the fabrication of X-ray zone plates with feature sizes as small as 25 nm in optical elements with overall sizes on the order of 1 cm. The CXRO technology has significant flexibility in terms of pattern geometry, and is thus capable of producing linear transmission gratings with aperture sizes similar to SEM and ESP but with four times the dispersion. With such dispersion, reasonable spectral resolution (< 1nm) can be obtained using commercial off-the shelf (COTS) X-ray sensitive AXUV type silicon photodiodes from the Optodiode Corp. in an instrument with overall size and mass similar to that of SEM or ESP.

  15. Focused ion beam patterned Fe thin films A study by selective area Stokes polarimetry and soft x-Ray microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Cook, P. J.; Shen, T. H.; Grundy, P. J.; Im, M.-Y.; Fischer, P.; Morton, S. A.; Kilcoyne, A. L. D.

    2010-11-14

    We demonstrate the potential to modify the magnetic behavior and structural properties of ferromagnetic thin films using focused ion beam 'direct-write' lithography. Patterns inspired by the split-ring resonators often used as components in meta-materials were defined upon 15 nm Fe films using a 30 keV Ga{sup +} focused ion beam at a dose of 2 x 10{sup 16} ions cm{sup -2}. Structural, chemical and magnetic changes to the Fe were studied using transmission soft X-ray microscopy at the ALS, Berkeley CA. X-ray absorption spectra showed a 23% reduction in the thickness of the film in the Ga irradiated areas, but no chemical change to the Fe was evident. X-ray images of the magnetic reversal process show domain wall pinning around the implanted areas, resulting in an overall increase in the coercivity of the film. Transmission electron microscopy showed significant grain growth in the implanted regions.

  16. High-speed, two-dimensional synchrotron white-beam x-ray radiography of spray breakup and atomization.

    Science.gov (United States)

    Halls, Benjamin R; Radke, Christopher D; Reuter, Benjamin J; Kastengren, Alan L; Gord, James R; Meyer, Terrence R

    2017-01-23

    High-speed, two-dimensional synchrotron x-ray radiography and phase-contrast imaging are demonstrated in propulsion sprays. Measurements are performed at the 7-BM beamline at the Advanced Photon Source user facility at Argonne National Laboratory using a recently developed broadband x-ray white beam. This novel enhancement allows for high speed, high fidelity x-ray imaging for the community at large. Quantitative path-integrated liquid distributions and spatio-temporal dynamics of the sprays were imaged with a LuAG:Ce scintillator optically coupled to a high-speed CMOS camera. Images are collected with a microscope objective at frame rates of 20 kHz and with a macro lens at 120 kHz, achieving spatial resolutions of 12 μm and 65 μm, respectively. Imaging with and without potassium iodide (KI) as a contrast-enhancing agent is compared, and the effects of broadband attenuation and spatial beam characteristics are determined through modeling and experimental calibration. In addition, phase contrast is used to differentiate liquid streams with varying concentrations of KI. The experimental approach is applied to different spray conditions, including quantitative measurements of mass distribution during primary atomization and qualitative visualization of turbulent binary fluid mixing.

  17. X-ray micro-beam techniques and phase contrast tomography applied to biomaterials

    Energy Technology Data Exchange (ETDEWEB)

    Fratini, Michela, E-mail: michela.fratini@gmail.com [Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, 00184 Roma (Italy); Dipartimento di Scienze, Università di Roma Tre, 00144 Roma (Italy); Campi, Gaetano [Institute of Crystallography, CNR, 00015 Monterotondo, Roma (Italy); Bukreeva, Inna [CNR NANOTEC-Institute of Nanotechnology, 00195 Roma (Italy); P.N. Lebedev Physical Institute RAS, 119991 Moscow (Russian Federation); Pelliccia, Daniele [School of Physics, Monash University, Victoria 3800 (Australia); Burghammer, Manfred [ESRF-The European Synchrotron, 3800 Grenoble (France); Tromba, Giuliana [Sincrotrone Trieste SCpA, 34149 Basovizza, Trieste (Italy); Cancedda, Ranieri; Mastrogiacomo, Maddalena [Dipartimento di Medicina Sperimentale dell’Università di Genova & AUO San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova (Italy); Cedola, Alessia [CNR NANOTEC-Institute of Nanotechnology, 00195 Roma (Italy)

    2015-12-01

    A deeper comprehension of the biomineralization (BM) process is at the basis of tissue engineering and regenerative medicine developments. Several in-vivo and in-vitro studies were dedicated to this purpose via the application of 2D and 3D diagnostic techniques. Here, we develop a new methodology, based on different complementary experimental techniques (X-ray phase contrast tomography, micro-X-ray diffraction and micro-X-ray fluorescence scanning technique) coupled to new analytical tools. A qualitative and quantitative structural investigation, from the atomic to the micrometric length scale, is obtained for engineered bone tissues. The high spatial resolution achieved by X-ray scanning techniques allows us to monitor the bone formation at the first-formed mineral deposit at the organic–mineral interface within a porous scaffold. This work aims at providing a full comprehension of the morphology and functionality of the biomineralization process, which is of key importance for developing new drugs for preventing and healing bone diseases and for the development of bio-inspired materials.

  18. X-ray micro-beam techniques and phase contrast tomography applied to biomaterials

    Science.gov (United States)

    Fratini, Michela; Campi, Gaetano; Bukreeva, Inna; Pelliccia, Daniele; Burghammer, Manfred; Tromba, Giuliana; Cancedda, Ranieri; Mastrogiacomo, Maddalena; Cedola, Alessia

    2015-12-01

    A deeper comprehension of the biomineralization (BM) process is at the basis of tissue engineering and regenerative medicine developments. Several in-vivo and in-vitro studies were dedicated to this purpose via the application of 2D and 3D diagnostic techniques. Here, we develop a new methodology, based on different complementary experimental techniques (X-ray phase contrast tomography, micro-X-ray diffraction and micro-X-ray fluorescence scanning technique) coupled to new analytical tools. A qualitative and quantitative structural investigation, from the atomic to the micrometric length scale, is obtained for engineered bone tissues. The high spatial resolution achieved by X-ray scanning techniques allows us to monitor the bone formation at the first-formed mineral deposit at the organic-mineral interface within a porous scaffold. This work aims at providing a full comprehension of the morphology and functionality of the biomineralization process, which is of key importance for developing new drugs for preventing and healing bone diseases and for the development of bio-inspired materials.

  19. Strain mapping in an InGaN/GaN nanowire using a nano-focused x-ray beam

    Energy Technology Data Exchange (ETDEWEB)

    Stankevič, Tomaš, E-mail: Tomas.Stankevic@nbi.dk; Feidenhans' l, Robert [Niels Bohr Institute, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen (Denmark); Dzhigaev, Dmitry; Vartanyants, Ivan A. [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, D-22607 Hamburg (Germany); National Research Nuclear University, MEPhI (Moscow Engineering Physics Institute), Kashirskoe shosse 31, 115409 Moscow (Russian Federation); Bi, Zhaoxia; Mikkelsen, Anders; Samuelson, Lars [NanoLund, Department of Physics, Lund University, P.O. Box 118, 22 100 Lund (Sweden); Rose, Max; Shabalin, Anatoly; Reinhardt, Juliane; Falkenberg, Gerald [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, D-22607 Hamburg (Germany)

    2015-09-07

    Strained InGaN/GaN core-shell nanowires (NWs) are promising candidates for solid state lighting applications due to their superior properties compared to planar films. NW based devices consist of multiple functional layers, which sum up to many hundred nanometers in thickness, that can uniquely be accessed in a non-destructive fashion by hard X-rays. Here, we present a detailed nanoscale strain mapping performed on a single, 400 nm thick and 2 μm long core-shell InGaN/GaN nanowire with an x-ray beam focused down to 100 nm. We observe an inhomogeneous strain distribution caused by the asymmetric strain relaxation in the shell. One side of the InGaN shell was fully strained, whereas the other side and the top part were relaxed. Additionally, tilt and strain gradients were determined at the interface with the substrate.

  20. Combined total body X-ray irradiation and total skin electron beam radiotherapy with an improved technique for mycosis fungoides

    Energy Technology Data Exchange (ETDEWEB)

    Halberg, F.E.; Fu, K.K.; Weaver, K.A.; Zackheim, H.S.; Epstein, E.H. Jr.; Wintroub, B.U.

    1989-08-01

    Twelve consecutive patients with advanced stage mycosis fungoides (MF) were treated with combined total body X ray irradiation (TBI) and total skin electron beam radiotherapy (EBRT). Six had generalized plaque disease and dermatopathic nodes, three had tumor stage disease and node biopsy positive for mycosis fungoides, and three had erythroderma/Sezary syndrome. The treatment regimen consisted of split course total body X ray irradiation, given in twice weekly 15 cGy fractions to 75 cGy, then total skin electron beam radiation therapy given in once weekly 400 cGy fractions to a total dose of 2400 cGy. Underdosed areas and areas of greatest initial involvement were boosted 400 cGy twice weekly for an additional 1200 cGy. This was followed by a second course of total body X ray irradiation, to a total dose of 150 cGy. The total skin electron beam radiotherapy technique is a modification of an established six position EBRT technique for mycosis fungoides. Measurements to characterize the beam with and without a lexan scattering plate, demonstrated that the combination of no-plate beams produced better dose uniformity with a much higher dose rate. This improved technique is particularly advantageous for elderly and/or frail patients. Nine (75%) of the 12 patients achieved complete response (CR). The other three had significant improvement with greater than 80% clearing of their disease and resolution of symptoms. All six patients with generalized plaque disease achieved complete response and remained free of disease from 2 to 16 months. Two of three node positive patients also achieved complete response; one, with massive biopsy-documented mycosis fungoides nodal disease and deep open tumors, remained relapse-free over 2 years. Only one of the three patients with erythroderma/Sezary syndrome achieved a complete response, which was short lived.

  1. Feasibility study of silicon PN photodiodes as X-ray intensity monitors for high flux X-ray beam with synchrotron radiation

    CERN Document Server

    Sato, K

    1999-01-01

    The basic properties of silicon PN photodiodes as X-ray detectors with synchrotron radiation and their application to XAFS measurements have been investigated. The effects of diffraction peaks due to the crystalline structure of the photodiodes have been eliminated by mounting the scintillators on the photodiodes; (1) CsI(Tl) crystal as a X-ray total absorption detection medium and (2) plastic scintillator as a non-crystalline solid state X-ray detection medium. An accurate comparison between XAFS signals detected by ionization chambers and silicon PN photodiodes is presented. It is shown that good quality XAFS measurements with silicon PN photodiodes are possible by eliminating the diffraction effects with scintillator photodiode configurations.

  2. Algorithm for X-ray scatter, beam-hardening, and beam profile correction in diagnostic (kilovoltage) and treatment (megavoltage) cone beam CT.

    Science.gov (United States)

    Maltz, Jonathan S; Gangadharan, Bijumon; Bose, Supratik; Hristov, Dimitre H; Faddegon, Bruce A; Paidi, Ajay; Bani-Hashemi, Ali R

    2008-12-01

    Quantitative reconstruction of cone beam X-ray computed tomography (CT) datasets requires accurate modeling of scatter, beam-hardening, beam profile, and detector response. Typically, commercial imaging systems use fast empirical corrections that are designed to reduce visible artifacts due to incomplete modeling of the image formation process. In contrast, Monte Carlo (MC) methods are much more accurate but are relatively slow. Scatter kernel superposition (SKS) methods offer a balance between accuracy and computational practicality. We show how a single SKS algorithm can be employed to correct both kilovoltage (kV) energy (diagnostic) and megavoltage (MV) energy (treatment) X-ray images. Using MC models of kV and MV imaging systems, we map intensities recorded on an amorphous silicon flat panel detector to water-equivalent thicknesses (WETs). Scattergrams are derived from acquired projection images using scatter kernels indexed by the local WET values and are then iteratively refined using a scatter magnitude bounding scheme that allows the algorithm to accommodate the very high scatter-to-primary ratios encountered in kV imaging. The algorithm recovers radiological thicknesses to within 9% of the true value at both kV and megavolt energies. Nonuniformity in CT reconstructions of homogeneous phantoms is reduced by an average of 76% over a wide range of beam energies and phantom geometries.

  3. Methods for assisting recovery of damaged brain and spinal cord using arrays of X-Ray microplanar beams

    Science.gov (United States)

    Dilmanian, F. Avraham; McDonald, III, John W.

    2007-12-04

    A method of assisting recovery of an injury site of brain or spinal cord injury includes providing a therapeutic dose of X-ray radiation to the injury site through an array of parallel microplanar beams. The dose at least temporarily removes regeneration inhibitors from the irradiated regions. Substantially unirradiated cells surviving between the microplanar beams migrate to the in-beam irradiated portion and assist in recovery. The dose may be administered in dose fractions over several sessions, separated in time, using angle-variable intersecting microbeam arrays (AVIMA). Additional doses may be administered by varying the orientation of the microplanar beams. The method may be enhanced by injecting stem cells into the injury site.

  4. New x-ray pink-beam profile monitor system for the SPring-8 beamline front-end

    Science.gov (United States)

    Takahashi, Sunao; Kudo, Togo; Sano, Mutsumi; Watanabe, Atsuo; Tajiri, Hiroo

    2016-08-01

    A new beam profile monitoring system for the small X-ray beam exiting from the SPring-8 front-end was developed and tested at BL13XU. This system is intended as a screen monitor and also as a position monitor even at beam currents of 100 mA by using photoluminescence of a chemical vapor deposition-grown diamond film. To cope with the challenge that the spatial distribution of the photoluminescence in the vertical direction is too flat to detect the beam centroid within a limited narrow aperture, a filter was installed that absorbs the fundamental harmonic concentrated in the beam center, which resulted in "de-flattening" of the vertical distribution. For the measurement, the filter crossed the photon beam vertically at high speed to withstand the intense heat flux of the undulator pink-beam. A transient thermal analysis, which can simulate the movement of the irradiation position with time, was conducted to determine the appropriate configuration and the required moving speed of the filter to avoid accidental melting. In a demonstration experiment, the vertically separated beam profile could be successfully observed for a 0.8 × 0.8 mm2 beam shaped by an XY slit and with a fundamental energy of 18.48 keV. The vertical beam centroid could be detected with a resolution of less than 0.1 mm.

  5. Large area CMOS active pixel sensor x-ray imager for digital breast tomosynthesis: Analysis, modeling, and characterization

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Chumin; Kanicki, Jerzy, E-mail: kanicki@eecs.umich.edu [Solid-State Electronics Laboratory, Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan 48109 (United States); Konstantinidis, Anastasios C. [Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, United Kingdom and Diagnostic Radiology and Radiation Protection, Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester M20 4BX (United Kingdom); Patel, Tushita [Department of Physics, University of Virginia, Charlottesville, Virginia 22908 (United States)

    2015-11-15

    Purpose: Large area x-ray imagers based on complementary metal-oxide-semiconductor (CMOS) active pixel sensor (APS) technology have been proposed for various medical imaging applications including digital breast tomosynthesis (DBT). The low electronic noise (50–300 e{sup −}) of CMOS APS x-ray imagers provides a possible route to shrink the pixel pitch to smaller than 75 μm for microcalcification detection and possible reduction of the DBT mean glandular dose (MGD). Methods: In this study, imaging performance of a large area (29 × 23 cm{sup 2}) CMOS APS x-ray imager [Dexela 2923 MAM (PerkinElmer, London)] with a pixel pitch of 75 μm was characterized and modeled. The authors developed a cascaded system model for CMOS APS x-ray imagers using both a broadband x-ray radiation and monochromatic synchrotron radiation. The experimental data including modulation transfer function, noise power spectrum, and detective quantum efficiency (DQE) were theoretically described using the proposed cascaded system model with satisfactory consistency to experimental results. Both high full well and low full well (LFW) modes of the Dexela 2923 MAM CMOS APS x-ray imager were characterized and modeled. The cascaded system analysis results were further used to extract the contrast-to-noise ratio (CNR) for microcalcifications with sizes of 165–400 μm at various MGDs. The impact of electronic noise on CNR was also evaluated. Results: The LFW mode shows better DQE at low air kerma (K{sub a} < 10 μGy) and should be used for DBT. At current DBT applications, air kerma (K{sub a} ∼ 10 μGy, broadband radiation of 28 kVp), DQE of more than 0.7 and ∼0.3 was achieved using the LFW mode at spatial frequency of 0.5 line pairs per millimeter (lp/mm) and Nyquist frequency ∼6.7 lp/mm, respectively. It is shown that microcalcifications of 165–400 μm in size can be resolved using a MGD range of 0.3–1 mGy, respectively. In comparison to a General Electric GEN2 prototype DBT system (at

  6. Design and fabrication of soft x-ray photolithography experimental beam line at Beijing National Synchrotron Radiation Laboratory

    Science.gov (United States)

    Zhou, Changxin

    1991-08-01

    The synchrotron radiation (SR) soft x-ray photolithography experimental beam line (3B1 beam line) at Beijing National Synchrotron Radiation Laboratory, was completed and tested in June 1990. A soft x-ray photolithography experiment was successfully completed, and the width of linear etch on a silicon chip by the device with a 3B1 beam line is up to 0.5 micrometers . This SR soft x-ray photolithography experiment was done successfully for the first time in China. This paper describes the design of the beam line and the fabrication of the most important optical element--the cylindrical scanning mirror in the beam line. The 3B1 beam line consists of the shielding light plate with water-cooling, laser simulation light source system, 3-D adjustable scanning mirror, high pass-band filer (beryllium window), acoustic sensor, helium gas chamber, and vacuum system. The main specifications of the 3B1 beam line are as follows: spectral range 0.4-2 nm; horizontal acceptance angle 7.5 mrad; vertical acceptance angle 0.4 mrad; grazing incidence angle 1.5 deg; light spot size 35 nm X 12 nm; vacuum degree of the mirror box 5 X 10-10 torr (static). The cylindrical scanning mirror in grazing incidence is used in the beam line for photolithography to obtain uniform distributed intensity of illumination of the SR source in the vertical direction (Gaussian distribution) and sufficiently concentrated energy. It is made of aluminum alloy LD2 with a supersmooth optical surface. The curvature radius of the cylindrical surface is 527.5 mm; surface figure error is less than (lambda) /10; surface roughness is better than 1 nm RMS, and fold coating on the surface of the mirror under UHV of 109 torr. The laser simulation light source system is used for adjusting the optical system in the beam line instead of the SR source. The cylindrical mirror was polished supersmoothly using Al2O3 ultra micropower grinding material made in TOMAS in Japan on modified traditional machine tools, and surface

  7. A versatile facility for the calibration of X-ray polarimeters with polarized and unpolarized controlled beams

    CERN Document Server

    Muleri, Fabio; Bellazzini, Ronaldo; Brez, Alessandro; Costa, Enrico; Frutti, Massimo; Mastropietro, Marcello; Morelli, Ennio; Pinchera, Michele; Rubini, Alda; Spandre, Gloria

    2008-01-01

    We devised and built a versatile facility for the calibration of the next generation X-ray polarimeters with unpolarized and polarized radiation. The former is produced at 5.9 keV by means of a Fe55 radioactive source or by X-ray tubes, while the latter is obtained by Bragg diffraction at nearly 45 degrees. Crystals tuned with the emission lines of X-ray tubes with molybdenum, rhodium, calcium and titanium anodes are employed for the efficient production of highly polarized photons at 2.29, 2.69, 3.69 and 4.51 keV respectively. Moreover the continuum emission is exploited for the production of polarized photons at 1.65 keV and 2.04 keV and at energies corresponding to the higher orders of diffraction. The photons are collimated by means of interchangeable capillary plates and diaphragms, allowing a trade-off between collimation and high fluxes. The direction of the beam is accurately arranged by means of high precision motorized stages, controlled via computer so that long and automatic measurements can be do...

  8. An expanded X-ray beam facility (BEaTriX) to test the modular elements of the ATHENA optics

    CERN Document Server

    Spiga, D; Bonnini, E; Buffagni, E; Ferrari, C; Pareschi, G; Tagliaferri, G

    2015-01-01

    Future large X-ray observatories like ATHENA will be equipped with very large optics, obtained by assembling modular optical elements, named X-ray Optical Units (XOU) based on the technology of either Silicon Pore Optics or Slumped Glass Optics. In both cases, the final quality of the modular optic (a 5 arcsec HEW requirement for ATHENA) is determined by the accuracy alignment of the XOUs within the assembly, but also by the angular resolution of the individual XOU. This is affected by the mirror shape accuracy, its surface roughness, and the mutual alignment of the mirrors within the XOU itself. Because of the large number of XOUs to be produced, quality tests need to be routinely done to select the most performing stacked blocks, to be integrated into the final optic. In addition to the usual metrology based on profile and roughness measurements, a direct measurement with a broad, parallel, collimated and uniform X- ray beam would be the most reliable test, without the need of a focal spot reconstruction as...

  9. Twin robotic x-ray system for 2D radiographic and 3D cone-beam CT imaging

    Science.gov (United States)

    Fieselmann, Andreas; Steinbrener, Jan; Jerebko, Anna K.; Voigt, Johannes M.; Scholz, Rosemarie; Ritschl, Ludwig; Mertelmeier, Thomas

    2016-03-01

    In this work, we provide an initial characterization of a novel twin robotic X-ray system. This system is equipped with two motor-driven telescopic arms carrying X-ray tube and flat-panel detector, respectively. 2D radiographs and fluoroscopic image sequences can be obtained from different viewing angles. Projection data for 3D cone-beam CT reconstruction can be acquired during simultaneous movement of the arms along dedicated scanning trajectories. We provide an initial evaluation of the 3D image quality based on phantom scans and clinical images. Furthermore, initial evaluation of patient dose is conducted. The results show that the system delivers high image quality for a range of medical applications. In particular, high spatial resolution enables adequate visualization of bone structures. This system allows 3D X-ray scanning of patients in standing and weight-bearing position. It could enable new 2D/3D imaging workflows in musculoskeletal imaging and improve diagnosis of musculoskeletal disorders.

  10. Patient dose simulations for scanning-beam digital x-ray tomosynthesis of the lungs

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, Geoff; Fahrig, Rebecca [Department of Radiology, Stanford University, Stanford, California 94305 (United States); Yoon, Sungwon [Varian Medical Systems, Palo Alto, California 94304 (United States); Krishna, Ganesh [Palo Alto Medical Foundation, Mountain View, California 94040 (United States); Wilfley, Brian [Triple Ring Technologies, Inc., Newark, California 94560 (United States)

    2013-11-15

    location. When tumor SNR is held constant (i.e., x-ray fluence is scaled appropriately), SBDX gives 2–10 times less dose than fluoroscopy for the same conditions within the typical range of patient locations. The relative position of the patient (as a percent of SDD) has a much more significant impact on dose than either SDD or patient position. The patient position providing the minimum dose for a given tumor SNR and SDD is approximately the same as the position of maximum tomographic angle.Conclusions: SBDX offers a significant dose advantage over currently used C-arm fluoroscopy. The patient location with lowest dose coincides with the location of maximum tomographic angle. In order to provide adequate space for the patient and for the pulmonologists’ equipment, a SDD of 100 cm is recommended.

  11. Complex aberrations in lymphocytes exposed to mixed beams of (241)Am alpha particles and X-rays.

    Science.gov (United States)

    Staaf, Elina; Deperas-Kaminska, Marta; Brehwens, Karl; Haghdoost, Siamak; Czub, Joanna; Wojcik, Andrzej

    2013-08-30

    Modern radiotherapy treatment modalities are associated with undesired out-of-field exposure to complex mixed beams of high and low energy transfer (LET) radiation that can give rise to secondary cancers. The biological effectiveness of mixed beams is not known. The aim of the investigation was the analysis of chromosomal damage in human peripheral blood lymphocytes (PBL) exposed to a mixed beam of X-rays and alpha particles. Using a dedicated exposure facility PBL were exposed to increasing doses of alpha particles (from (241)Am), X-rays and a mixture of both. Chromosomal aberrations were analysed in chromosomes 2, 8 and 14 using fluorescence in situ hybridisation. The found and expected frequencies of simple and complex aberrations were compared. Simple aberrations showed linear dose-response relationships with doses. A higher than expected frequency of simple aberrations was only observed after the highest mixed beam dose. A linear-quadratic dose response curve for complex aberrations was observed after mixed-beam exposure. Higher than expected frequencies of complex aberrations were observed for the two highest doses. Both the linear-quadratic dose-response relationship and the calculation of expected frequencies show that exposure of PBL to mixed beams of high and low LET radiation leads to a higher than expected frequency of complex-type aberrations. Because chromosomal changes are associated with cancer induction this result may imply that the cancer risk of exposure to mixed beams in radiation oncology may be higher than expected based on the additive action of the individual dose components.

  12. Imaging Molecular Signatures of Breast Cancer with X-ray-Activated Nanophosphors

    Science.gov (United States)

    2014-01-01

    the high X-ray noise from the incident irradiation, and the dark counts from thermal noise on the CCD. After connecting the chiller and installing...below a manufacturer-recommended value; this optimal value was chosen to remove low- intensity pixels which corresponded to thermal and read noise on the...distinguish between the different sized objects in the optical dimension, although again, there is a tendency for dilation in the optically-resolved

  13. Ensuring convergence in total-variation-based reconstruction for accurate microcalcification imaging in breast X-ray CT

    CERN Document Server

    Jørgensen, Jakob H; Pan, Xiaochuan

    2011-01-01

    Breast X-ray CT imaging is being considered in screening as an extension to mammography. As a large fraction of the population will be exposed to radiation, low-dose imaging is essential. Iterative image reconstruction based on solving an optimization problem, such as Total-Variation minimization, shows potential for reconstruction from sparse-view data. For iterative methods it is important to ensure convergence to an accurate solution, since important image features, such as presence of microcalcifications indicating breast cancer, may not be visible in a non-converged reconstruction, and this can have clinical significance. To prevent excessively long computational times, which is a practical concern for the large image arrays in CT, it is desirable to keep the number of iterations low, while still ensuring a sufficiently accurate reconstruction for the specific imaging task. This motivates the study of accurate convergence criteria for iterative image reconstruction. In simulation studies with a realistic...

  14. Image performance of a new amorphous selenium flat panel x-ray detector designed for digital breast tomosynthesis

    Science.gov (United States)

    Cheung, L. K.; Jing, Z.; Bogdanovich, S.; Golden, K.; Robinson, S.; Beliaevskaia, E.; Parikh, S.

    2005-04-01

    The purpose of this work is to report the performance of an amorphous selenium (a-Se) based flat-panel x-ray imager under development for application in digital breast tomosynthesis. This detector is designed to perform both in the conventional Full Field Digital Mammography (FFDM) mode and the tomosynthesis mode. The large area 24 x 29 cm detector achieves rapid image acquisition rates of up to 4 frames per second with minimal trapped charge induced effects such as ghost or lag images of previously acquired objects. In this work, a new a-Se/TFT detector layer structure is evaluated. The design uses a top conductive layer in direct contact with the a-Se x-ray detection layer. The simple structure has few layers and minimal hole and electron trapping effects. Prototype detectors were built to investigate the basic image performance of this new a-Se/TFT detector. Image signal generation, image ghosting, image lag, and detector DQE were studied. For digital mammography applications, the residual image ghosting was less than 1% at 30 seconds elapsed time. DQE, measured at a field of 5.15 V/um, showed significantly higher values over previously reported data, especially at low exposure levels. For digital breast tomosynthesis, the image lag at dynamic readout rate was < 0.6 % at 0.5-second elapsed time. A prototype tomosynthesis system is being developed utilizing this new a-Se/TFT detector.

  15. Oxidation of nanostructured Ti films produced by low energy cluster beam deposition: An X-ray Photoelectron Spectroscopy characterization

    Energy Technology Data Exchange (ETDEWEB)

    Simone, Monica de, E-mail: desimone@tasc.infm.it [CNR-IOM Laboratorio TASC, Area Science Park Basovizza, 34149 Trieste (Italy); Snidero, Elena [CNR-IOM Laboratorio TASC, Area Science Park Basovizza, 34149 Trieste (Italy); Coreno, Marcello [CNR-IMIP, c/o Laboratorio TASC Area Science Park Basovizza, 34149 Trieste (Italy); Sincrotrone Trieste ScpA, Area Science Park Basovizza, 34149 Trieste (Italy); Bongiorno, Gero [Fondazione Filarete, v.le Ortles 22/4, 20139 Milano (Italy); Giorgetti, Luca [Istituto Europeo di Oncologia, Dip. di Oncologia Sperimentale, Via Adamello 16, 20139, Milano (Italy); Amati, Matteo [Sincrotrone Trieste ScpA, Area Science Park Basovizza, 34149 Trieste (Italy); Cepek, Cinzia [CNR-IOM Laboratorio TASC, Area Science Park Basovizza, 34149 Trieste (Italy)

    2012-05-01

    We used in-situ X-ray Photoelectron Spectroscopy (XPS) to study the oxidation process of a cluster-assembled metallic titanium film exposed to molecular oxygen at room temperature. The nanostructured film has been grown on a Si(111) substrate, in ultra high vacuum conditions, by coupling a supersonic cluster beam deposition system with an XPS experimental chamber. Our results show that upon in-situ oxygen exposure Ti{sup 3+} is the first oxidation state observed, followed by Ti{sup 4+}, whereas Ti{sup 2+} is practically absent during the whole process. Our results compare well with the existing literature on Ti films produced using other techniques.

  16. A diffracted-beam monochromator for long linear detectors in X-ray diffractometers with Bragg-Brentano parafocusing geometry.

    Science.gov (United States)

    van der Pers, N M; Hendrikx, R W A; Delhez, R; Böttger, A J

    2013-04-01

    A new diffracted-beam monochromator has been developed for Bragg-Brentano X-ray diffractometers equipped with a linear detector. The monochromator consists of a cone-shaped graphite highly oriented pyrolytic graphite crystal oriented out of the equatorial plane such that the parafocusing geometry is preserved over the whole opening angle of the linear detector. In our standard setup a maximum wavelength discrimination of 3% is achieved with an overall efficiency of 20% and a small decrease in angular resolution of only 0.02 °2θ. In principle, an energy resolution as low as 1.5% can be achieved.

  17. Analysis on Residual Stress in Electron Beam-Physical Vapor Deposited Thermal Barrier Coating using Hard Synchrotron X-Rays

    OpenAIRE

    鈴木, 賢治; 松本, 一秀; 久保, 貴博; 町屋, 修太郎; 田中, 啓介; 秋庭, 義明; SUZUKI, Kenji; MATSUMOTO, Kazuhide; Kubo, Takahiro; Machiya, Syutaro; Tanaka, Keisuke; Akiniwa, Yoshiaki

    2005-01-01

    The distribution of the residual stress in the thermal barrier coating, which was made by an electron beam-physical vapor deposition (EB-PVD) method, was determined using X-ray stress measurements. As the bond coating, NiCoCrAlY was low-pressure plasma sprayed on the substrate of austenitic stainless steel. The 8 mass% Y_2O_3-ZrO_2 was coated on the bond coating using the EB-PVD method as the top coating. The top coating had the preferred orientation with the axis direction perpendicular to ...

  18. X-ray and ultrasound semiotics of mucinous carcinoma of the breast

    Directory of Open Access Journals (Sweden)

    K. A. Lesko

    2013-01-01

    Full Text Available The article describes the main epidemiological, clinical and morphological diagnostic features of one of the rare breast cancer form – mucinous carcinoma of the breast. Current scientific data are followed by the results of own research the 9-year period of research.Authors draw attention to the very complex radiology peculiarities of the mucinous carcinoma of the breast.

  19. Trace elements as tumor biomarkers and prognostic factors in breast cancer: a study through energy dispersive x-ray fluorescence

    Directory of Open Access Journals (Sweden)

    Silva Marina P

    2012-07-01

    Full Text Available Abstract Background The application and better understanding of traditional and new breast tumor biomarkers and prognostic factors are increasing due to the fact that they are able to identify individuals at high risk of breast cancer, who may benefit from preventive interventions. Also, biomarkers can make possible for physicians to design an individualized treatment for each patient. Previous studies showed that trace elements (TEs determined by X-Ray Fluorescence (XRF techniques are found in significantly higher concentrations in neoplastic breast tissues (malignant and benign when compared with normal tissues. The aim of this work was to evaluate the potential of TEs, determined by the use of the Energy Dispersive X-Ray Fluorescence (EDXRF technique, as biomarkers and prognostic factors in breast cancer. Methods By using EDXRF, we determined Ca, Fe, Cu, and Zn trace elements concentrations in 106 samples of normal and breast cancer tissues. Cut-off values for each TE were determined through Receiver Operating Characteristic (ROC analysis from the TEs distributions. These values were used to set the positive or negative expression. This expression was subsequently correlated with clinical prognostic factors through Fisher’s exact test and chi-square test. Kaplan Meier survival curves were also evaluated to assess the effect of the expression of TEs in the overall patient survival. Results Concentrations of TEs are higher in neoplastic tissues (malignant and benign when compared with normal tissues. Results from ROC analysis showed that TEs can be considered a tumor biomarker because, after establishing a cut-off value, it was possible to classify different tissues as normal or neoplastic, as well as different types of cancer. The expression of TEs was found statistically correlated with age and menstrual status. The survival curves estimated by the Kaplan-Meier method showed that patients with positive expression for Cu presented a poor

  20. Cone beam x-ray luminescence computed tomography reconstruction with a priori anatomical information

    Science.gov (United States)

    Lo, Pei-An; Lin, Meng-Lung; Jin, Shih-Chun; Chen, Jyh-Cheng; Lin, Syue-Liang; Chang, C. Allen; Chiang, Huihua Kenny

    2014-09-01

    X-ray luminescence computed tomography (XLCT) is a novel molecular imaging modality that reconstructs the optical distribution of x-ray-excited phosphor particles with prior informational of anatomical CT image. The prior information improves the accuracy of image reconstruction. The system can also present anatomical CT image. The optical system based on a high sensitive charge coupled device (CCD) is perpendicular with a CT system. In the XLCT system, the xray was adopted to excite the phosphor of the sample and CCD camera was utilized to acquire luminescence emitted from the sample in 360 degrees projection free-space. In this study, the fluorescence diffuse optical tomography (FDOT)-like algorithm was used for image reconstruction, the structural prior information was incorporated in the reconstruction by adding a penalty term to the minimization function. The phosphor used in this study is Gd2O2S:Tb. For the simulation and experiments, the data was collected from 16 projections. The cylinder phantom was 40 mm in diameter and contains 8 mm diameter inclusion; the phosphor in the in vivo study was 5 mm in diameter at a depth of 3 mm. Both the errors were no more than 5%. Based on the results from these simulation and experimental studies, the novel XLCT method has demonstrated the feasibility for in vivo animal model studies.

  1. X-ray beam-shaping via deformable mirrors: analytical computation of the required mirror profile

    CERN Document Server

    Spiga, Daniele; Svetina, Cristian; Zangrando, Marco; 10.1016/j.nima.2012.10.117

    2013-01-01

    X-ray mirrors with high focusing performances are in use in both mirror mod- ules for X-ray telescopes and in synchrotron and FEL (Free Electron Laser) beamlines. A degradation of the focus sharpness arises in general from geo- metrical deformations and surface roughness, the former usually described by geometrical optics and the latter by physical optics. In general, technological developments are aimed at a very tight focusing, which requires the mirror profile to comply with the nominal shape as much as possible and to keep the roughness at a negligible level. However, a deliberate deformation of the mirror can be made to endow the focus with a desired size and distribution, via piezo actuators as done at the EIS-TIMEX beamline of FERMI@Elettra. The resulting profile can be characterized with a Long Trace Profilometer and correlated with the expected optical quality via a wavefront propagation code. However, if the roughness contribution can be neglected, the com- putation can be performed via a ray-tracin...

  2. Imaging Molecular Signatures of Breast Cancer With X-ray Activated Nano-Phosphors

    Science.gov (United States)

    2011-09-01

    shot-noise limited detection" was assumed to be too low to detect. To calculate the molar concentration, we assumed a spherical 10 nm diameter...Kandarakis et al. !a" Minimum weight concentration !in mg/ml" vs dose !Gy". !b" Minimum molar concentration !in M" vs dose !Gy". a b c d FIG. 5. Agar imaging...Contrast agents: X-ray contrast agents and molecular imaging—A contradiction ?,” Handb Exp Pharmacol 185, 167–175 񓟸#. 3R. Weissleder and M. J. Pittet

  3. Design and Development of Ionization Chamber for Detection of X-Ray Beam AT INDUS-2 RRCAT

    Directory of Open Access Journals (Sweden)

    Nawaz Ali Sayed

    2013-02-01

    Full Text Available The goal of this paper was to design and develop a Microcontroller based data acquisition unit for detection of X-ray flux through Ionization chamber that will remotely control and monitor the ultra-low current signal detection analog module precisely. This application will be useful to measure the intensity of x-ray flux through the ionization chamber in a beam line of synchrotron radiation source which is mounted in INDUS-2. The beam line area is highly restricted because of hazardous radiation, so through this application remote interfacing provides for the ultra-low current signal detection card that can be controlled by personal computer. To design a perfect embedded system there are many issues like designing a proper PCB, to achieve the specified resolution of the ADC used in chip, code developed using any compiler should be within the limit of the memory of the microcontroller system and integrity of the devices used in the circuit. Initially explore and gain the knowledge of embedded systems by doing a small project and writing the code for the same, and gain a knowledge how the system works. Programming has done in assembly language 8051, for schematic design PCB design tool ORCAD (VERSION 9.0 use

  4. Analysis of axial spatial resolution in a variable resolution x-ray cone beam CT (VRX-CBCT) system

    Science.gov (United States)

    Dahi, Bahram; Keyes, Gary S.; Rendon, David A.; DiBianca, Frank A.

    2008-03-01

    The Variable Resolution X-ray (VRX) technique has been successfully used in a Cone-Beam CT (CBCT) system to increase the spatial resolution of CT images in the transverse plane. This was achieved by tilting the Flat Panel Detector (FPD) to smaller vrx y angles in a VRX Cone Beam CT (VRX-CBCT) system. In this paper, the effect on the axial spatial resolution of CT images created by the VRX-CBCT system is examined at different vrx x angles, where vrx x is the tilting angle of the FPD about its x-axis. An amorphous silicon FPD with a CsI scintillator is coupled with a micro-focus x-ray tube to form a CBCT. The FPD is installed on a rotating frame that allows rotation of up to 90° about x and y axes of the FPD. There is no rotation about the z-axis (i.e. normal to the imaging surface). Tilting the FPD about its x-axis (i.e. decreasing the vrx x angle) reduces both the width of the line-spread function and the sampling distance by a factor of sin vrx x, thereby increasing the theoretical detector pre-sampling spatial resolution proportionately. This results in thinner CT slices that in turn help increase the axial spatial resolution of the CT images. An in-house phantom is used to measure the MTF of the reconstructed CT images at different vrx x angles.

  5. Improved Diagnostics by Assessing the Micromorphology of Breast Calcifications via X-Ray Dark-Field Radiography

    Science.gov (United States)

    Scherer, Kai; Braig, Eva; Ehn, Sebastian; Schock, Jonathan; Wolf, Johannes; Birnbacher, Lorenz; Chabior, Michael; Herzen, Julia; Mayr, Doris; Grandl, Susanne; Sztrókay-Gaul, Anikó; Hellerhoff, Karin; Pfeiffer, Franz

    2016-11-01

    Breast microcalcifications play an essential role in the detection and evaluation of early breast cancer in clinical diagnostics. However, in digital mammography, microcalcifications are merely graded with respect to their global appearance within the mammogram, while their interior microstructure remains spatially unresolved and therefore not considered in cancer risk stratification. In this article, we exploit the sub-pixel resolution sensitivity of X-ray dark-field contrast for clinical microcalcification assessment. We demonstrate that the micromorphology, rather than chemical composition of microcalcification clusters (as hypothesised by recent literature), determines their absorption and small-angle scattering characteristics. We show that a quantitative classification of the inherent microstructure as ultra-fine, fine, pleomorphic and coarse textured is possible. Insights underlying the micromorphological nature of breast calcifications are verified by comprehensive high-resolution micro-CT measurements. We test the determined microtexture of microcalcifications as an indicator for malignancy and demonstrate its potential to improve breast cancer diagnosis, by providing a non-invasive tool for sub-resolution microcalcification assessment. Our results indicate that dark-field imaging of microcalcifications may enhance the diagnostic validity of current microcalcification analysis and reduce the number of invasive procedures.

  6. Impulsive solar X-ray bursts. III - Polarization, directivity, and spectrum of the reflected and total bremsstrahlung radiation from a beam of electrons directed toward the photosphere

    Science.gov (United States)

    Langer, S. H.; Petrosian, V.

    1977-01-01

    The paper presents the spectrum, directivity, and state of polarization of the bremsstrahlung radiation expected from a beam of high-energy electrons spiraling along radial magnetic field lines toward the photosphere. A Monte Carlo method is then described for evaluation of the spectrum, directivity, and polarization of X-rays diffusely reflected from stellar photospheres. The accuracy of the technique is evaluated through comparison with analytic results. The calculated characteristics of the incident X-rays are used to evaluate the spectrum, directivity, and polarization of the reflected and total X-ray fluxes. The results are compared with observations.

  7. Soft-X-ray spectra of highly charged Os, Bi, Th, and U ions in an electron beam ion trap

    Energy Technology Data Exchange (ETDEWEB)

    Trabert, E; Beiersdorfer, P; Fournier, K B; Chen, M H

    2004-12-03

    Systematic variation of the electron-beam energy in an electron-beam ion trap has been employed to produce soft-X-ray spectra of Os, Bi, Th, and U with highest charge states ranging up to Ni-like ions. Guided by relativistic atomic structure calculations, the strongest lines have been identified with {Delta}n = 0 (n = 4 to n' = 4) transitions in Rb- to Cu-like ions. The rather weak 4p-4d transitions are much less affected by QED contributions than the dominant 4s-4p transitions. Our wavelength measurements consequently provide benchmarks with and (almost) without QED. Because the radiative corrections are not very sensitive to the number of electrons in the valence shell, our data, moreover, provide benchmarks for the evaluation of electron-electron interactions.

  8. Simulating Cometary and Stellar X-ray Emission in the Laboratory Using Microcalorimeters and an Electron Beam Ion Trap

    Science.gov (United States)

    Brown, G. V.; Beiersdorfer, P.; Chen, H.; Graf, A.; May, M.; Terracol, S.; Thorn, D.; Boyce, K. R.; Cottam, J.; Gendreau, K. C.; Kahn, S. M.; Kelley, R. L.; Kilbourne, C. A.; Porter, F. S.; Szymkowiak, A. E.

    2004-10-01

    The mixing of atomic and macroscopic processes taking place in non-terrestrial objects creates complex, dynamic, and intriguing environments. High resolution x-ray spectra from these sources measured by satellites such as Chandra, XMM-Newton, and the Solar Maximum Mission provide a means for understanding the physics governing these sources. Laboratory measurements of the atomic processes have proved crucial to the interpretation of these spectra. For example using the LLNL electron beam ion traps EBIT-I & EBIT-II a detailed study of the x-ray spectrum of Fe XVII has been conducted addressing the large ratio predicted by theory compared to observations of considerably smaller values of the relative intensity of the 2p-3d 1P1 resonant to the 3D1 intercombination line. The difference was often attributed to opacity effects. However, laboratory measurements in the optically thin limit agree with observations demonstrating that the prediction is too large and opacity need not be invoked. The laboratory results thus provide a benchmark in the optically thin limit for accurate estimates of opacity effects . To uncover the source of the discrepancy between theory and observation, we have performed a series of experiments that successively uncovered more details about the Fe XVII lines produced in coronal plasmas. Most recently, we used a 32 channel array microcalorimeter from the Astro-E x-ray satellite program to measure the excitation cross section of various Fe XVII lines in the laboratory. These measurements resolve long-standing issues thought to be associated with non-equilibrium processes. We have also used the Astro-E microcalorimeter, and more recently its upgrade from the Astro-E2 project, and the magnetic trapping mode of EBIT-I to accurately measure x-ray emission from charge exchange recombination and to simulate the x-ray line production process in comets. Using only the laboratory measurements, we fit the moderate resolution x-ray spectrum from the comet C

  9. The X-ray emission of solar flares generated by anisotropic electron beams

    Science.gov (United States)

    Bogovalov, S. V.; Kelner, S. R.; Kotov, Y. D.

    1987-12-01

    For three types of the initial angle distribution of fast electrons, energy spectra, directivity, and polarization of the bremsstrahlung have been computed with an account for multiple scattering and energy losses. The influence of Compton scattering and of photoabsorption on the observed hard X-ray emission of solar flares has been investigated. It is obtained that the photon spectrum index depends not only on the spectrum of electrons but also on the registered energy range and on the angle of view of the flare. In the 10 - 40 keV range the spectrum is softer at the limb than in the solar disc centre; in the 60 - 360 keV the situation is reverse, the spectrum being softer in the solar disc centre.

  10. Devices for high precision x-ray beam intensity monitoring on BSRF

    CERN Document Server

    Hua-Peng, LI; Zhao, Yi-Dong; Zheng, Lei; Liu, Shu-Hu; Zhao, Xiao-Liang; Zhao, Ya-Shuai

    2016-01-01

    Synchrotron radiation with the characteristic of high brilliance, high level of polarization, high collimation, low emittance and wide tunability in energy has been used as a standard source in metrology(1, 2). For a decade, lots of calibration work have been done on 4B7A in Beijing Synchrotron Radiation Facility (BSRF) (3, 4). For the calibration process, a high-precision online monitor is indispensable. To control the uncertainty under 0.1%, we studied different sizes parallel ion chambers with rare-gas and used different collecting methods to monitor the x-ray intensity of the beamline. Two methods to collect the signal of the ion chambers: reading the current directly with electrometer or signal amplification to collect the counts were compared.

  11. Observer-model optimization of X-ray system in photon-counting breast imaging

    Science.gov (United States)

    Cederström, Björn; Fredenberg, Erik; Lundqvist, Mats; Ericson, Tove; Åslund, Magnus

    2011-08-01

    An ideal-observer model is applied to optimize the design of an X-ray tube intended for use in a multi-slit scanning photon-counting mammography system. The design is such that the anode and the heel effect are reversed and the projected focal spot is smallest at the chest wall. Using linear systems theory, detectability and dose efficiency for a 0.1-mm disk are calculated for different focal spot sizes and anode angles. It is shown that the image acquisition time can be reduced by about 25% with spatial resolution and dose efficiency improved near the chest wall and worsened further away. The image quality is significantly more homogeneous than for the conventional anode orientation, both with respect to noise and detectability of a small object. With the tube rotated 90∘, dose efficiency can be improved by 20% for a fixed image acquisition time.

  12. X-ray Fluorescence Sectioning

    CERN Document Server

    Cong, Wenxiang

    2012-01-01

    In this paper, we propose an x-ray fluorescence imaging system for elemental analysis. The key idea is what we call "x-ray fluorescence sectioning". Specifically, a slit collimator in front of an x-ray tube is used to shape x-rays into a fan-beam to illuminate a planar section of an object. Then, relevant elements such as gold nanoparticles on the fan-beam plane are excited to generate x-ray fluorescence signals. One or more 2D spectral detectors are placed to face the fan-beam plane and directly measure x-ray fluorescence data. Detector elements are so collimated that each element only sees a unique area element on the fan-beam plane and records the x-ray fluorescence signal accordingly. The measured 2D x-ray fluorescence data can be refined in reference to the attenuation characteristics of the object and the divergence of the beam for accurate elemental mapping. This x-ray fluorescence sectioning system promises fast fluorescence tomographic imaging without a complex inverse procedure. The design can be ad...

  13. Study of electron beams within ISTTOK tokamak by means of a multi-channel Cherenkov detector; their correlation with hard X-rays

    Energy Technology Data Exchange (ETDEWEB)

    Jakubowski, L., E-mail: Lech.Jakubowski@ipj.gov.p [Andrzej Soltan Institute for Nuclear Studies, 05-400 Otwock-Swierk (Poland); Malinowski, K.; Sadowski, M.J.; Zebrowski, J. [Andrzej Soltan Institute for Nuclear Studies, 05-400 Otwock-Swierk (Poland); Plyusnin, V.V. [Association Euratom/IST, Instituto de Plasmas e Fusao Nuclear, Instituto Superior Tecnico, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Rabinski, M. [Andrzej Soltan Institute for Nuclear Studies, 05-400 Otwock-Swierk (Poland); Fernandes, H.; Silva, C.; Duarte, P. [Association Euratom/IST, Instituto de Plasmas e Fusao Nuclear, Instituto Superior Tecnico, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Jakubowski, M.J. [Andrzej Soltan Institute for Nuclear Studies, 05-400 Otwock-Swierk (Poland)

    2010-11-11

    The paper describes experimental studies of electron beams emitted from a plasma torus within the ISTTOK tokamak, which were performed by means of a new four-channel detector of the Cherenkov type. A range of electron energy was estimated. There were also measured hard X-rays, and their correlation with the fast run-away electron beams was investigated experimentally.

  14. Measurement of L X-ray production cross sections by impact of proton beams on Hf, Ir, and Tl

    Energy Technology Data Exchange (ETDEWEB)

    Miranda, J., E-mail: miranda@fisica.unam.mx [Departamento de Aceleradores, Instituto Nacional de Investigaciones Nucleares, Carr. México-Toluca S/N, Ocoyoacac, Edo. Méx. 52750 (Mexico); Instituto de Física, Universidad Nacional Autónoma de México, A.P. 20-364, México D.F. 01000 (Mexico); Murillo, G.; Méndez, B.; López-Monroy, J.; Aspiazu, J.; Villaseñor, P. [Departamento de Aceleradores, Instituto Nacional de Investigaciones Nucleares, Carr. México-Toluca S/N, Ocoyoacac, Edo. Méx. 52750 (Mexico); Pineda, J.C.; Reyes-Herrera, J. [Instituto de Física, Universidad Nacional Autónoma de México, A.P. 20-364, México D.F. 01000 (Mexico)

    2013-12-01

    Highlights: • A new data set of L X-ray production cross sections by proton impact is given. • The incident energy range for elements {sub 72}Hf, {sub 77}Ir, and {sub 81}Tl extends up to 4.75 MeV. • The ECPSSR theory is used, with United Atom and Multiple Ionization corrections. • Intra-shell coupling is also considered. • Definite conclusions about theories are complicated by experimental uncertainties. -- Abstract: In spite of the existence of a large quantity of experimental results for X-ray production cross sections by proton beam impact, recent publications emphasize the need for more measurements in several targets and energy ranges. Following these recommendations, this work presents results with some heavy elements ({sub 72}Hf, {sub 77}Ir, and {sub 81}Tl) irradiated with protons in the energy interval 0.45 MeV–4.75 MeV. The results are compared with experimental data from previous publications, empirical tables, as well as with predictions of the ECPSSR theory with the United Atom modification, intra-shell coupling corrections, and Multiple Ionization effects. Although there is good coincidence with previous experiments, the agreement among the theories with the experimental data does not allow a definitive conclusion about the best predictions for the measured cross sections.

  15. X-ray absorption microtomography (microCT) and small beam diffraction mapping of sea urchin teeth.

    Science.gov (United States)

    Stock, S R; Barss, J; Dahl, T; Veis, A; Almer, J D

    2002-07-01

    Two noninvasive X-ray techniques, laboratory X-ray absorption microtomography (microCT) and X-ray diffraction mapping, were used to study teeth of the sea urchin Lytechinus variegatus. MicroCT revealed low attenuation regions at near the tooth's stone part and along the carinar process-central prism boundary; this latter observation appears to be novel. The expected variation of Mg fraction x in the mineral phase (calcite, Ca(1-x)Mg(x)CO(3)) cannot account for all of the linear attenuation coefficient decrease in the two zones: this suggested that soft tissue is localized there. Transmission diffraction mapping (synchrotron X-radiation, 80.8 keV, 0.1 x 0.1mm(2) beam area, 0.1mm translation grid, image plate area detector) simultaneously probed variations in 3-D and showed that the crystal elements of the "T"-shaped tooth were very highly aligned. Diffraction patterns from the keel (adaxial web) and from the abaxial flange (containing primary plates and the stone part) differed markedly. The flange contained two populations of identically oriented crystal elements with lattice parameters corresponding to x=0.13 and x=0.32. The keel produced one set of diffraction spots corresponding to the lower x. The compositions were more or less equivalent to those determined by others for camarodont teeth, and the high Mg phase is expected to be disks of secondary mineral epitaxially related to the underlying primary mineral element. Lattice parameter gradients were not noted in the keel or flange. Taken together, the microCT and diffraction results indicated that there was a band of relatively high protein content, of up to approximately 0.25 volume fraction, in the central part of the flange and paralleling its adaxial and abaxial faces. X-ray microCT and microdiffraction data used in conjunction with protein distribution data will be crucial for understanding the properties of various biocomposites and their mechanical functions.

  16. EXACTRAC x-ray and beam isocenters--What's the difference?

    Energy Technology Data Exchange (ETDEWEB)

    Tideman Arp, Dennis; Carl, Jesper [Department of Medical Physics, Oncology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, DK-9100 Aalborg (Denmark)

    2012-03-15

    Purpose: To evaluate the geometric accuracy of the isocenter of an image-guidance system, as implemented in the exactrac system from brainlab, relative to the linear accelerator radiation isocenter. Subsequently to correct the x-ray isocenter of the exactrac system for any geometric discrepancies between the two isocenters. Methods: Five Varian linear accelerators all equipped with electronic imaging devices and exactrac with robotics from brainlab were evaluated. A commercially available Winston-Lutz phantom and an in-house made adjustable base were used in the setup. The electronic portal imaging device of the linear accelerators was used to acquire MV-images at various gantry angles. Stereoscopic pairs of x-ray images were acquired using the exactrac system. The deviation between the position of the external laser isocenter and the exactrac isocenter was evaluated using the commercial software of the exactrac system. In-house produced software was used to analyze the MV-images and evaluate the deviation between the external laser isocenter and the radiation isocenter of the linear accelerator. Subsequently, the deviation between the radiation isocenter and the isocenter of the exactrac system was calculated. A new method of calibrating the isocenter of the exactrac system was applied to reduce the deviations between the radiation isocenter and the exactrac isocenter. Results: To evaluate the geometric accuracy a 3D deviation vector was calculated for each relative isocenter position. The 3D deviation between the external laser isocenter and the isocenter of the exactrac system varied from 0.21 to 0.42 mm. The 3D deviation between the external laser isocenter and the linac radiation isocenter ranged from 0.37 to 0.83 mm. The 3D deviation between the radiation isocenter and the isocenter of the exactrac system ranged from 0.31 to 1.07 mm. Using the new method of calibrating the exactrac isocenter the 3D deviation of one linac was reduced from 0.90 to 0.23 mm. The

  17. Electron contamination in 4 MV and 10 MV radiotherapy x-ray beams.

    Science.gov (United States)

    Harper, N R; Metcalfe, P E; Hoban, P W; Round, W H

    1991-09-01

    A thin window parallel-plate ionization chamber was constructed for dose measurement in the build-up region of high energy radiotherapy photon beams. The chamber is an integral part of a perspex block. The entrance window is 12 microns Melinex foil with a thin aluminium surface. Cavity thickness is 1.45 mm. Surface doses for varying field sizes were found to increase almost linearly with the side length of a square field. The surface dose for a 10x10 cm 4 MV photon beam is 12.1% for an open field and this increases to 14.1% with a polycarbonate block tray in the beam. Similarly for a 10 MV photon beam the surface dose is 10.6% for an open field and this increases to 12.4% with a polycarbonate block tray. The difference between the dose for an open field and a field with a polycarbonate block tray inserted becomes more significant for larger field sizes. Electron contamination depth dose curves are determined for a 4 MV and 10 MV photon beam. This is achieved by subtracting a pure photon beam build-up curve generated by an EGS4 Monte Carlo simulation from the experimental build-up curve. The EGS4 curve is a theoretical, electron contamination free curve. The electron contamination curve (of the 10 MV photon beam) has depth dose characteristics similar to that of a broad low energy electron beam.

  18. Accelerating statistical image reconstruction algorithms for fan-beam x-ray CT using cloud computing

    Science.gov (United States)

    Srivastava, Somesh; Rao, A. Ravishankar; Sheinin, Vadim

    2011-03-01

    Statistical image reconstruction algorithms potentially offer many advantages to x-ray computed tomography (CT), e.g. lower radiation dose. But, their adoption in practical CT scanners requires extra computation power, which is traditionally provided by incorporating additional computing hardware (e.g. CPU-clusters, GPUs, FPGAs etc.) into a scanner. An alternative solution is to access the required computation power over the internet from a cloud computing service, which is orders-of-magnitude more cost-effective. This is because users only pay a small pay-as-you-go fee for the computation resources used (i.e. CPU time, storage etc.), and completely avoid purchase, maintenance and upgrade costs. In this paper, we investigate the benefits and shortcomings of using cloud computing for statistical image reconstruction. We parallelized the most time-consuming parts of our application, the forward and back projectors, using MapReduce, the standard parallelization library on clouds. From preliminary investigations, we found that a large speedup is possible at a very low cost. But, communication overheads inside MapReduce can limit the maximum speedup, and a better MapReduce implementation might become necessary in the future. All the experiments for this paper, including development and testing, were completed on the Amazon Elastic Compute Cloud (EC2) for less than $20.

  19. Area X-ray or UV camera system for high-intensity beams

    Science.gov (United States)

    Chapman, Henry N.; Bajt, Sasa; Spiller, Eberhard A.; Hau-Riege, Stefan , Marchesini, Stefano

    2010-03-02

    A system in one embodiment includes a source for directing a beam of radiation at a sample; a multilayer mirror having a face oriented at an angle of less than 90 degrees from an axis of the beam from the source, the mirror reflecting at least a portion of the radiation after the beam encounters a sample; and a pixellated detector for detecting radiation reflected by the mirror. A method in a further embodiment includes directing a beam of radiation at a sample; reflecting at least some of the radiation diffracted by the sample; not reflecting at least a majority of the radiation that is not diffracted by the sample; and detecting at least some of the reflected radiation. A method in yet another embodiment includes directing a beam of radiation at a sample; reflecting at least some of the radiation diffracted by the sample using a multilayer mirror; and detecting at least some of the reflected radiation.

  20. Physical dose distribution due to multi-sliced kV X-ray beam in labeled tissue-like media: An experimental approach

    Energy Technology Data Exchange (ETDEWEB)

    Ghasemi, M., E-mail: mghasemi@nrcam.or [Agricultural Medical and Industrial Research School, NSTRI, P.O. Box 31485-498, Karaj (Iran, Islamic Republic of); Kakuee, O.R.; Fathollahi, V. [Van de Graaff Laboratory, Nuclear Science Research School, NSTRI, P.O. Box 14395-836, Tehran (Iran, Islamic Republic of); Shahvar, A.; Mohati, M.; Ghafoori, M. [Agricultural Medical and Industrial Research School, NSTRI, P.O. Box 31485-498, Karaj (Iran, Islamic Republic of)

    2011-02-15

    Radiotherapy remains a major modality of cancer therapy. Thanks to high flux and high brilliance of synchrotron-generated X-ray, laboratory research with planar microscopically thin X-ray beam promise exciting new opportunities for treatment of cancer. High tolerance of normal tissues at doses up to several hundred Gy in a single dose fraction and preferential damage of tumors at very high doses have been uniquely observed in animal models exposed to microbeams. The fact that beams as thick as 0.68 mm could retain a part of these effects, opens the possibility that the required beam can be produced by high power X-ray tubes besides a dedicated synchrotron. Fortunately, dose distribution due to kilovolt X-rays could be enhanced by the introduction of high-Z contrast agents to tissue-like media. In this work, dose deposition in a phantom-partially loaded with Au and I as contrast agents-irradiated by multi-sliced kV X-ray beam was experimentally investigated in the peak and valley regions both on the surface and in the depth of phantom. The results of experimental dosimetry using Gaf-chromic films were compared with corresponding Monte-Carlo simulation. Relative reduction in the deposited dose in the peak regions downstream the area containing contrast agents in comparison with the adjacent areas was experimentally observed.

  1. Physical dose distribution due to multi-sliced kV X-ray beam in labeled tissue-like media: an experimental approach.

    Science.gov (United States)

    Ghasemi, M; Kakuee, O R; Fathollahi, V; Shahvar, A; Mohati, M; Ghafoori, M

    2011-02-01

    Radiotherapy remains a major modality of cancer therapy. Thanks to high flux and high brilliance of synchrotron-generated X-ray, laboratory research with planar microscopically thin X-ray beam promise exciting new opportunities for treatment of cancer. High tolerance of normal tissues at doses up to several hundred Gy in a single dose fraction and preferential damage of tumors at very high doses have been uniquely observed in animal models exposed to microbeams. The fact that beams as thick as 0.68 mm could retain a part of these effects, opens the possibility that the required beam can be produced by high power X-ray tubes besides a dedicated synchrotron. Fortunately, dose distribution due to kilovolt X-rays could be enhanced by the introduction of high-Z contrast agents to tissue-like media. In this work, dose deposition in a phantom--partially loaded with Au and I as contrast agents--irradiated by multi-sliced kV X-ray beam was experimentally investigated in the peak and valley regions both on the surface and in the depth of phantom. The results of experimental dosimetry using Gaf-chromic films were compared with corresponding Monte-Carlo simulation. Relative reduction in the deposited dose in the peak regions downstream the area containing contrast agents in comparison with the adjacent areas was experimentally observed.

  2. Research and Design of a Sample Heater for Beam Line 6-2c Transmission X-ray Microscope

    Energy Technology Data Exchange (ETDEWEB)

    Policht, Veronica; /Loyola U., Chicago /SLAC

    2012-08-27

    There exists a need for environmental control of samples to be imaged by the Transmission X-Ray Microscope (TXM) at the SSRLs Beam Line 6-2c. In order to observe heat-driven chemical or morphological changes that normally occur in situ, microscopes require an additional component that effectively heats a given sample without heating any of the microscope elements. The confinement of the heat and other concerns about the heaters integrity limit which type of heater is appropriate for the TXM. The bulk of this research project entails researching different heating methods used previously in microscopes, but also in other industrial applications, with the goal of determining the best-fitting method, and finally in designing a preliminary sample heater.

  3. X-Ray Diffraction Apparatus

    Science.gov (United States)

    Blake, David F. (Inventor); Bryson, Charles (Inventor); Freund, Friedmann (Inventor)

    1996-01-01

    An x-ray diffraction apparatus for use in analyzing the x-ray diffraction pattern of a sample is introduced. The apparatus includes a beam source for generating a collimated x-ray beam having one or more discrete x-ray energies, a holder for holding the sample to be analyzed in the path of the beam, and a charge-coupled device having an array of pixels for detecting, in one or more selected photon energy ranges, x-ray diffraction photons produced by irradiating such a sample with said beam. The CCD is coupled to an output unit which receives input information relating to the energies of photons striking each pixel in the CCD, and constructs the diffraction pattern of photons within a selected energy range striking the CCD.

  4. Three-dimensional cascaded system analysis of a 50 µm pixel pitch wafer-scale CMOS active pixel sensor x-ray detector for digital breast tomosynthesis

    Science.gov (United States)

    Zhao, C.; Vassiljev, N.; Konstantinidis, A. C.; Speller, R. D.; Kanicki, J.

    2017-03-01

    High-resolution, low-noise x-ray detectors based on the complementary metal-oxide-semiconductor (CMOS) active pixel sensor (APS) technology have been developed and proposed for digital breast tomosynthesis (DBT). In this study, we evaluated the three-dimensional (3D) imaging performance of a 50 µm pixel pitch CMOS APS x-ray detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). The two-dimensional (2D) angle-dependent modulation transfer function (MTF), normalized noise power spectrum (NNPS), and detective quantum efficiency (DQE) were experimentally characterized and modeled using the cascaded system analysis at oblique incident angles up to 30°. The cascaded system model was extended to the 3D spatial frequency space in combination with the filtered back-projection (FBP) reconstruction method to calculate the 3D and in-plane MTF, NNPS and DQE parameters. The results demonstrate that the beam obliquity blurs the 2D MTF and DQE in the high spatial frequency range. However, this effect can be eliminated after FBP image reconstruction. In addition, impacts of the image acquisition geometry and detector parameters were evaluated using the 3D cascaded system analysis for DBT. The result shows that a wider projection angle range (e.g.  ±30°) improves the low spatial frequency (below 5 mm‑1) performance of the CMOS APS detector. In addition, to maintain a high spatial resolution for DBT, a focal spot size of smaller than 0.3 mm should be used. Theoretical analysis suggests that a pixelated scintillator in combination with the 50 µm pixel pitch CMOS APS detector could further improve the 3D image resolution. Finally, the 3D imaging performance of the CMOS APS and an indirect amorphous silicon (a-Si:H) thin-film transistor (TFT) passive pixel sensor (PPS) detector was simulated and compared.

  5. Three-dimensional cascaded system analysis of a 50 µm pixel pitch wafer-scale CMOS active pixel sensor x-ray detector for digital breast tomosynthesis.

    Science.gov (United States)

    Zhao, C; Vassiljev, N; Konstantinidis, A C; Speller, R D; Kanicki, J

    2017-03-07

    High-resolution, low-noise x-ray detectors based on the complementary metal-oxide-semiconductor (CMOS) active pixel sensor (APS) technology have been developed and proposed for digital breast tomosynthesis (DBT). In this study, we evaluated the three-dimensional (3D) imaging performance of a 50 µm pixel pitch CMOS APS x-ray detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). The two-dimensional (2D) angle-dependent modulation transfer function (MTF), normalized noise power spectrum (NNPS), and detective quantum efficiency (DQE) were experimentally characterized and modeled using the cascaded system analysis at oblique incident angles up to 30°. The cascaded system model was extended to the 3D spatial frequency space in combination with the filtered back-projection (FBP) reconstruction method to calculate the 3D and in-plane MTF, NNPS and DQE parameters. The results demonstrate that the beam obliquity blurs the 2D MTF and DQE in the high spatial frequency range. However, this effect can be eliminated after FBP image reconstruction. In addition, impacts of the image acquisition geometry and detector parameters were evaluated using the 3D cascaded system analysis for DBT. The result shows that a wider projection angle range (e.g.  ±30°) improves the low spatial frequency (below 5 mm(-1)) performance of the CMOS APS detector. In addition, to maintain a high spatial resolution for DBT, a focal spot size of smaller than 0.3 mm should be used. Theoretical analysis suggests that a pixelated scintillator in combination with the 50 µm pixel pitch CMOS APS detector could further improve the 3D image resolution. Finally, the 3D imaging performance of the CMOS APS and an indirect amorphous silicon (a-Si:H) thin-film transistor (TFT) passive pixel sensor (PPS) detector was simulated and compared.

  6. Using submicron-resolution LiF crystal and film x-ray detectors for the near and far fields in-situ characterization of soft x-ray laser beams

    Science.gov (United States)

    Pikuz, Tatiana A.; Faenov, Anatoly Y.; Fukuda, Yuji; Kato, Yoshiaki; Kawachi, Tetsuya; Kando, Masaki

    2012-01-01

    Review of results, obtained by using recently proposed new imaging detector, based on formation of color centers in LiF crystal and LiF film, for in situ high performance measurements of near-field and far-field properties of soft X-ray lasers (SXRL) beams is presented. Experiments have been carried out with laser-driven transient-collision plasma SXRL and free electron SXRL beams. It was demonstrated that due to favorable combination of high spatial resolution, high dynamic range and wide field of view this technique allows measuring not only intensity distribution across the full beam and in local areas, but also permits to evaluate coherence and spectral distribution of radiation across the beam. Experimental diffraction patterns in the images of periodical structures are analyzed by comparison with the modeled ones in the last case. The estimated accuracy of measurements is between 10-20%.

  7. X-ray FEL based on harmonics generation and electron beam outcoupling

    Energy Technology Data Exchange (ETDEWEB)

    Litvinenko, V.N.; Burnham, B. [Duke Univ., Durham, NC (United States)

    1995-12-31

    Electron beam outcoupling was suggested by N. A. Vinokurov as a method of optics independent outcoupling for high power FELs. The bunching of the electron beam is provided in a master oscillator. The prebunched electron beam then radiates coherently into an additional wiggler called the radiator. The electron beam is turned by an achromatic bend into this wiggler and its radiation propagates with a small angle with respect to the OK-4 optical axis. Thus, the radiation will pass around the mirror of the master oscillator optical cavity and can then be utilized. This scheme is perfectly suited for harmonic generation if the radiator wiggler is tuned on one of the master oscillator wavelength harmonics. This system is reminiscent of a klystron operating on a harmonic of the reference frequency. In this paper we present the theory of this device, its spectral and spatial characteristics of radiation, the optimization of the master oscillator, the achromatic bend and bunching for harmonic generation, and influence of beam parameters (energy spread, emittance, etc.) on generated power. Examples of possible storage ring and linac driven systems are discussed.

  8. Measurement of photoneutron doses in and out of high-energy X-ray beam of a SATURNE-20 medical linear accelerator by ECE polycarbonate detectors

    CERN Document Server

    Sohrabi, M

    1999-01-01

    Photoneutron contaminations in and out of high energy X-ray beams of the medical linear accelerator SATURNE 20 (CGR) of the Radiotherapy Department of Omeed Hospital in Isfahan, Iran, have been determined using 250 mu m polycarbonate (PC) dosimeters, in strips or in sheets, processed by electrochemical etching (ECE) using specially designed ECE chambers to etch larger sheets. A two dimensional or topographical distribution of neutron contamination was also determined in a full size beam. The neutron dose equivalents (Hn) in the beam of 18 MV X-rays at 80 cm FSD were determined to be linear functions of X-ray dose equivalents (Hx) up to 1400 cSv. The distribution of the Hn at different X-ray doses showed bell-shape profiles with maxima at the isocenter. The ratios of dose equivalents of neutrons to those of X-rays increased as the field size increased having values of 0.22%, 0.28%, 0.31% and 0.37% for field sizes of 10x10, 20x20, 30x30, and 40x40 cm sup 2 respectively. Although such neutron dose equivalents ca...

  9. Hadron Cancer Therapy - relative merits of X-ray, proton and carbon beams

    Science.gov (United States)

    Jakel, Oliver

    2014-03-01

    -Heidelberg University has a long experience in radiotherapy with carbon ions, starting with a pilot project at GSI in 1997. This project was jointly run by the Dep. for Radiation Oncology of Heidelberg University, GSI and the German Cancer Research Center (DKFZ). A hospital based heavy ion center at Heidelberg University, the Heidelberg Ion Beam Therapy Center (HIT) was proposed by the same group in 1998 and started clinical operation in late 2009. Since then nearly 2000 patients were treated with beams of carbon ions and protons. Just recently the operation of the world's first and only gantry for heavy ions also started at HIT. Patient treatments are performed in three rooms. Besides that, a lot of research projects are run in the field of Medical Physics and Radiobiology using a dedicated experimental area and the possibility to use beams of protons, carbon, helium and oxygen ions being delivered with the raster scanning technique.

  10. Proton- and x-ray beams generated by ultra-fast CO(2) lasers for medical applications

    Energy Technology Data Exchange (ETDEWEB)

    Pogorelsky, I.; Polyanskiy, M.; Yakimenko, V.; Ben-Zvi, I.; Shkolnikov, P. Najmudin, Z.; Palmer, C.A.J.; Dover, N.P.; Oliva, P; Carpinelli, M.

    2011-07-01

    Recent progress in using picosecond CO{sub 2} lasers for Thomson scattering and ion-acceleration experiments underlines their potentials for enabling secondary radiation- and particle-sources. These experiments capitalize on certain advantages of long-wavelength CO{sub 2} lasers, such as higher number of photons per energy unit, and favorable scaling of the electrons ponderomotive energy and critical plasma density. The high-flux x-ray bursts produced by Thomson scattering of the CO{sub 2} laser off a counter-propagating electron beam enabled high-contrast, time-resolved imaging of biological objects in the picosecond time frame. In different experiments, the laser, focused on a hydrogen jet, generated monoenergetic proton beams via the radiation-pressure mechanism. The strong power-scaling of this regime promises realization of proton beams suitable for laser-driven proton cancer therapy after upgrading the CO{sub 2} laser to sub-PW peak power. This planned improvement includes optimizing the 10-{mu}m ultra-short pulse generation, assuring higher amplification in the CO{sub 2} gas under combined isotopic- and power-broadening effects, and shortening the postamplification pulse to a few laser cycles (150-200 fs) via chirping and compression. These developments will move us closer to practical applications of ultra-fast CO{sub 2} lasers in medicine and other areas.

  11. Phase-preserving beam expander for biomedical X-ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Martinson, Mercedes, E-mail: mercedes.m@usask.ca [University of Saskatchewan, 116 Science Place, Rm 163, Saskatoon, Saskatchewan (Canada); Samadi, Nazanin [University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan (Canada); Bassey, Bassey [University of Saskatchewan, 116 Science Place, Rm 163, Saskatoon, Saskatchewan (Canada); Gomez, Ariel [Canadian Light Source, 44 Innovation Boulevard, Saskatoon, Saskatchewan (Canada); Chapman, Dean [University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan (Canada); University of Saskatchewan, 116 Science Place, Rm 163, Saskatoon, Saskatchewan (Canada)

    2015-04-15

    Building on previous work, a phase-preserving bent Laue beam-expanding monochromator was developed with the capability of performing live animal phase contrast dynamic imaging at the Biomedical Imaging and Therapy beamline at the Canadian Light Source. The BioMedical Imaging and Therapy beamlines at the Canadian Light Source are used by many researchers to capture phase-based imaging data. These experiments have so far been limited by the small vertical beam size, requiring vertical scanning of biological samples in order to image their full vertical extent. Previous work has been carried out to develop a bent Laue beam-expanding monochromator for use at these beamlines. However, the first attempts exhibited significant distortion in the diffraction plane, increasing the beam divergence and eliminating the usefulness of the monochromator for phase-related imaging techniques. Recent work has been carried out to more carefully match the polychromatic and geometric focal lengths in a so-called ‘magic condition’ that preserves the divergence of the beam and enables full-field phase-based imaging techniques. The new experimental parameters, namely asymmetry and Bragg angles, were evaluated by analysing knife-edge and in-line phase images to determine the effect on beam divergence in both vertical and horizontal directions, using the flat Bragg double-crystal monochromator at the beamline as a baseline. The results show that by using the magic condition, the difference between the two monochromator types is less than 10% in the diffraction plane. Phase fringes visible in test images of a biological sample demonstrate that this difference is small enough to enable in-line phase imaging, despite operating at a sub-optimal energy for the wafer and asymmetry angle that was used.

  12. Complete blood counts, liver function tests, and chest x-rays as routine screening in early-stage breast cancer: value added or just cost?

    Science.gov (United States)

    Louie, Raphael J; Tonneson, Jennifer E; Gowarty, Minda; Goodney, Philip P; Barth, Richard J; Rosenkranz, Kari M

    2015-11-01

    Current National Comprehensive Cancer Network guidelines for breast cancer staging include pre-treatment complete blood count (CBC) and liver function tests (LFT) to screen for occult metastatic disease. To date, the relevance of these tests in detecting metastatic disease in asymptomatic women with early-stage breast cancer (Stage I/II) has not been demonstrated. Although chest x-rays are no longer recommended in the NCCN guidelines, many centers continue to include this imaging as part of their screening process. We aim to determine the clinical and financial impact of these labs and x-rays in the evaluation of early-stage breast cancer patients. A single institution IRB-approved retrospective chart review was conducted of patients with biopsy-proven invasive breast cancer treated from January 1, 2005–December 31, 2009. We collected patient demographics, clinical and pathologic staging, chest x-ray, CBC, and LFT results at the time of referral. Patients were stratified according to radiographic stage at the time of diagnosis. We obtained Medicare reimbursement fees for cost analysis. From 2005 to 2009, 1609 patients with biopsy-proven invasive breast cancer were treated at our institution. Of the 1082 patients with radiographic stage I/II disease, 27.3 % of patients had abnormal CBCs. No additional testing was performed to evaluate these abnormalities. In the early-stage population, 24.7 % of patients had elevated LFTs, resulting in 84 additional imaging studies. No metastatic disease was detected. The cost of CBC, LFTs and chest x-rays was $110.20 per patient, totaling $106,410.99. Additional tests prompted by abnormal results cost $58,143.30 over the five-year period. We found that pre-treatment CBCs, LFTs, and chest x-rays did not improve detection of occult metastatic disease but resulted in additional financial costs. Avoiding routine ordering of these tests would save the US healthcare system $25.7 million annually.

  13. Possibility of Ion Beam Pulse Compression by X-Ray Conversion

    Science.gov (United States)

    Yabe, Takashi

    1985-02-01

    A previously proposed scheme for ion beam pulse compression is reexamined from a different viewpoint. It is shown that the criticisms made by Unterseer and Meyer-ter-Vehn are not reasonable in a real target configuration. In addition, the spherically converging effect is shown to offer further advantages.

  14. Synchrotron X-ray studies of the keel of the short-spined sea urchin Lytechinus variegatus: absorption microtomography (microCT) and small beam diffraction mapping.

    Science.gov (United States)

    Stock, S R; Barss, J; Dahl, T; Veis, A; Almer, J D; Carlo, F

    2003-05-01

    In sea urchin teeth, the keel plays an important structural role, and this paper reports results of microstructural characterization of the keel of Lytechinus variegatus using two noninvasive synchrotron x-ray techniques: x-ray absorption microtomography (microCT) and x-ray diffraction mapping. MicroCT with 14 keV x-rays mapped the spatial distribution of mineral at the 1.3 microm level in a millimeter-sized fragment of a mature portion of the keel. Two rows of low absorption channels (i.e., primary channels) slightly less than 10 microm in diameter were found running linearly from the flange to the base of the keel and parallel to its sides. The primary channels paralleled the oral edge of the keel, and the microCT slices revealed a planar secondary channel leading from each primary channel to the side of the keel. The primary and secondary channels were more or less coplanar and may correspond to the soft tissue between plates of the carinar process. Transmission x-ray diffraction with 80.8 keV x-rays and a 0.1 mm beam mapped the distribution of calcite crystal orientations and the composition Ca(1-x)Mg(x)CO(3) of the calcite. Unlike the variable Mg concentration and highly curved prisms found in the keel of Paracentrotus lividus, a constant Mg content (x = 0.13) and relatively little prism curvature was found in the keel of Lytechinus variegatus.

  15. SU-E-T-298: Dosimetric Assessment of Using Brass Mesh Bolus with High Energy X-Ray Beams

    Energy Technology Data Exchange (ETDEWEB)

    Manger, R; Yock, A; Soultan, D; Harry, T; Cervino, L [University of California, San Diego, La Jolla, CA (United States)

    2015-06-15

    Purpose: Brass mesh bolus has been shown to be an acceptable substitute for tissue equivalent bolus to increase superficial dose for 6 MV chest wall tangent plans. It may be advantageous to deliver a portion of the treatment using higher energy beams to decrease dose heterogeneity. The purpose of this study is to investigate the photoneutron production and activation of brass mesh bolus by high energy x-ray beams. Methods: MCNPX was used to determine brass mesh photoneutron energy spectrum and PDDs for 15 MV and 24 MV beams. PDD and photoneutron spectra were determined with and without photoneutron production to assess the contribution of photoneutrons to CAX dose. Brass mesh was placed on a solid water slab phantom and irradiated with 500 MU of 15 MV photons at 100cm SSD. A Geiger-Mueller counter was used to record counts in 10-second intervals for 30 minutes. A survey meter was used to estimate dose on contact immediately following irradiation. Results: The thickness of brass mesh bolus for MCNPX simulation was 0.4 mm. The PDDs with and without photoneutron production were statistically equivalent (i.e. the increase in neutron dose at the central axis is insignificant). Using ICRP 103 dose conversion coefficients, the increase in effective dose from en-face delivery of 300 MU was 0.047 mSv for 15 MV and 0.525 mSV for 24 MV. The dose rate on contact after the 500 MU irradiation was 0.4 mrem/hr. The effective half-life was estimated to approximately 6 minutes. Conclusion: The use of brass mesh bolus with high energy beams does not significantly affect central axis PDD. The use of a 24 MV beam with brass bolus results in nearly 10 times the increase in effective dose as with 15 MV. The activation products produced by brass bolus have an effective half-life of approximately 6 minutes.

  16. Measurements of Hard X-Ray Emission Suggest Absorption Along the Path of the Inner Beams in High Foot Implosion Experiments on the NIF

    Science.gov (United States)

    Ralph, Joseph; Pak, Arthur; Otto, Landen; Kritcher, Andrea; Ma, Tammy; Charles, Jarrott; Callahan, Debra; Hinkel, Denise; Berzak Hopkins, Laura; Moody, John; Khan, Shahab; Doeppner, Tilo; Rygg, Ryan; Hurricane, Omar

    2016-10-01

    The current high foot hohlraum design fielded on the National Ignition Facility is aimed at providing uniform x-ray drive to provide a spherical implosion by lowering the gas fill from 1.6 to 0.6 mg/cc and increasing the hohlraum width from 5.75 to 6.72 mm while maintaining the same 1.8 mm capsule diameter from previous designs. These changes are intended to improve beam propagation without the need for crossed beam energy transfer. Analysis of the measurements of hard x-ray emission from the gated x-ray detector (GXD) and the static x-ray imager (SXI) looking through the laser entrance hole indicate a significant fraction of the inner beam incident energy is absorbed in the high z blow-off region (either uranium or gold) before reaching the inner wall near the equator. Comparison of inner beam absorption in this region and its effect on the implosion symmetry measurements will be presented. Additionally, the sensitivity of this absorption feature and therefore the implosion symmetry to the pulse shape, hohlraum fill pressure and fraction of energy in beams depositing energy at the hohlraum equator will be discussed. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  17. X-ray fluorescence and ion beam analysis of iridescent Art Nouveau glass - authenticity and technology

    Science.gov (United States)

    Jembrih-Simbürger, D.; Neelmeijer, C.; Mäder, M.; Schreiner, M.

    2004-11-01

    EDXRF analysis with subsequent multivariate data analysis proves useful for the determination of the authenticity of iridescent glass artifacts. Thus, clusters of the glass groups investigated were formed which can be associated with the glass manufacturers. By means of ion beam analysis with the external proton beam the producing technology of iridescent glass objects of the Art Nouveau glass manufacturer Loetz/Austria with so-called Papillon pattern was characterised in a non-destructive way. Due to the simultaneous application of PIXE and RBS the glass structure including a sequence of glass layers covered with a SnO 2-layer of approximately 50 nm thickness on the surface could be described.

  18. X-ray fluorescence and ion beam analysis of iridescent Art Nouveau glass - authenticity and technology

    Energy Technology Data Exchange (ETDEWEB)

    Jembrih-Simbuerger, D. E-mail: d.jembrih@akbild.ac.at; Neelmeijer, C.; Maeder, M.; Schreiner, M

    2004-11-01

    EDXRF analysis with subsequent multivariate data analysis proves useful for the determination of the authenticity of iridescent glass artifacts. Thus, clusters of the glass groups investigated were formed which can be associated with the glass manufacturers. By means of ion beam analysis with the external proton beam the producing technology of iridescent glass objects of the Art Nouveau glass manufacturer Loetz/Austria with so-called Papillon pattern was characterised in a non-destructive way. Due to the simultaneous application of PIXE and RBS the glass structure including a sequence of glass layers covered with a SnO{sub 2}-layer of approximately 50 nm thickness on the surface could be described.

  19. Patient dose simulations for scanning-beam digital x-ray tomosynthesis of the lungs

    OpenAIRE

    Nelson, Geoff; Yoon, Sungwon; Krishna, Ganesh; Wilfley, Brian; Fahrig, Rebecca

    2013-01-01

    Purpose: An improved method of image guidance for lung tumor biopsies could help reduce the high rate of false negatives. The aim of this work is to optimize the geometry of the scanning-beam digital tomography system (SBDX) for providing real-time 3D tomographic reconstructions for target verification. The unique geometry of the system requires trade-offs between patient dose, imaging field of view (FOV), and tomographic angle.

  20. Application of wide-angle scattering techniques using microfocus X-ray beam to investigate structural variation in polymer laminates

    Energy Technology Data Exchange (ETDEWEB)

    Bhagat, R

    1999-09-01

    Experiments have been conducted at the European Synchrotron Radiation Facility (ESRF) at Grenoble (France). The Synchrotron Radiation used provides a monochromatic X-ray beam with brilliance and flux density far greater than is attainable with a rotating anode laboratory source. In addition the glass capillary optics used, increases the flux density at the capillary exit as well as providing a sub-micron beam which coupled with the XYZ stage allows data to be collected at high spatial resolution. A Photonics Science CCD detector coupled to a frame grabber has permitted data to be collected at high temporal resolution (40ms) as well as displaying the data in real-time mode. Software used during analysis was used to reduce the amount of spurious signals due to background scatter as well as enable results to be calculated with a high degree of confidence. The aim of this research was to investigate the effect of industrial processing parameters in production of PET laminates and PEN films. Wide Angle X-ray Scattering (WAXS) patterns have been collected, using a beam size of 2.3 {mu}m at intervals of 1 {mu}m through the sample. Crystallite sizeand orientation analyses on patterns collected have been used as an indication of changes in the structural morphology through the thickness of the films. Data analyses of PET films show that biaxial stretching of films is very complex and depending on the parameters at each stage of the process, the final film has very different characteristics. It has been shown that the effects of draw ratio and draw temperature in the forward direction results in a range of crystallite sizes that lead to either crystal fracture or reorientation of the crystallites as the dominant process in the transverse draw. The effects of annealing can also lead to crystal welding or melting and re-crystallisation depending on the amount of time spent in the lamination process. Data analyses of PEN films show that the choice of parameters in biaxial

  1. Photo neutron dose equivalent rate in 15 MV X-ray beam from a Siemens Primus Linac.

    Science.gov (United States)

    Ghasemi, A; Pourfallah, T Allahverdi; Akbari, M R; Babapour, H; Shahidi, M

    2015-01-01

    Fast and thermal neutron fluence rates from a 15 MV X-ray beams of a Siemens Primus Linac were measured using bare and moderated BF3 proportional counter inside the treatment room at different locations. Fluence rate values were converted to dose equivalent rate (DER) utilizing conversion factors of American Association of Physicist in Medicine's (AAPM) report number 19. For thermal neutrons, maximum and minimum DERs were 3.46 × 10(-6) (3 m from isocenter in +Y direction, 0 × 0 field size) and 8.36 × 10(-8) Sv/min (in maze, 40 × 40 field size), respectively. For fast neutrons, maximum DERs using 9" and 3" moderators were 1.6 × 10(-5) and 1.74 × 10(-5) Sv/min (2 m from isocenter in +Y direction, 0 × 0 field size), respectively. By changing the field size, the variation in thermal neutron DER was more than the fast neutron DER and the changes in fast neutron DER were not significant in the bunker except inside the radiation field. This study showed that at all points and distances, by decreasing field size of the beam, thermal and fast neutron DER increases and the number of thermal neutrons is more than fast neutrons.

  2. Photo neutron dose equivalent rate in 15 MV X-ray beam from a Siemens Primus Linac

    Directory of Open Access Journals (Sweden)

    A Ghasemi

    2015-01-01

    Full Text Available Fast and thermal neutron fluence rates from a 15 MV X-ray beams of a Siemens Primus Linac were measured using bare and moderated BF 3 proportional counter inside the treatment room at different locations. Fluence rate values were converted to dose equivalent rate (DER utilizing conversion factors of American Association of Physicist in Medicine′s (AAPM report number 19. For thermal neutrons, maximum and minimum DERs were 3.46 × 10 -6 (3 m from isocenter in +Y direction, 0 × 0 field size and 8.36 × 10 -8 Sv/min (in maze, 40 × 40 field size, respectively. For fast neutrons, maximum DERs using 9" and 3" moderators were 1.6 × 10 -5 and 1.74 × 10 -5 Sv/min (2 m from isocenter in +Y direction, 0 × 0 field size, respectively. By changing the field size, the variation in thermal neutron DER was more than the fast neutron DER and the changes in fast neutron DER were not significant in the bunker except inside the radiation field. This study showed that at all points and distances, by decreasing field size of the beam, thermal and fast neutron DER increases and the number of thermal neutrons is more than fast neutrons.

  3. Mean Glandular dose coefficients (DgN) for x-ray spectra used in contemporary breast imaging systems

    Science.gov (United States)

    Nosratieh, Anita; Hernandez, Andrew; Shen, Sam Z.; Yaffe, Martin J.; Seibert, J. Anthony; Boone, John M.

    2015-01-01

    Purpose To develop tables of normalized glandular dose coefficients DgN for a range of anode–filter combinations and tube voltages used in contemporary breast imaging systems. Methods Previously published mono-energetic DgN values were used with various spectra to mathematically compute DgN coefficients. The tungsten anode spectra from TASMICS were used; Molybdenum and Rhodium anode-spectra were generated using MCNPx Monte Carlo code. The spectra were filtered with various thicknesses of Al, Rh, Mo or Cu. An initial HVL calculation was made using the anode and filter material. A range of the HVL values was produced with the addition of small thicknesses of polymethyl methacrylate (PMMA) as a surrogate for the breast compression paddle, to produce a range of HVL values at each tube voltage. Using a spectral weighting method, DgN coefficients for the generated spectra were calculated for breast glandular densities of 0%, 12.5%, 25%, 37.5%, 50% and 100% for a range of compressed breast thicknesses from 3 to 8 cm. Results Eleven tables of normalized glandular dose (DgN) coefficients were produced for the following anode/filter combinations: W + 50 μm Ag, W + 500 μm Al, W + 700 μm Al, W + 200 μm Cu, W + 300 μm Cu, W + 50 μm Rh, Mo + 400 μm Cu, Mo + 30 μm Mo, Mo + 25 μm Rh, Rh + 400 μm Cu and Rh + 25 μm Rh. Where possible, these results were compared to previously published DgN values and were found to be on average less than 2% different than previously reported values. Conclusion Over 200-pages of DgN coefficients were computed for modeled x-ray system spectra that are used in a number of new breast imaging applications. The reported values were found to be in excellent agreement when compared to published values. PMID:26348995

  4. Mean glandular dose coefficients (D(g)N) for x-ray spectra used in contemporary breast imaging systems.

    Science.gov (United States)

    Nosratieh, Anita; Hernandez, Andrew; Shen, Sam Z; Yaffe, Martin J; Seibert, J Anthony; Boone, John M

    2015-09-21

    To develop tables of normalized glandular dose coefficients D(g)N for a range of anode-filter combinations and tube voltages used in contemporary breast imaging systems. Previously published mono-energetic D(g)N values were used with various spectra to mathematically compute D(g)N coefficients. The tungsten anode spectra from TASMICS were used; molybdenum and rhodium anode-spectra were generated using MCNPX Monte Carlo code. The spectra were filtered with various thicknesses of Al, Rh, Mo or Cu. An initial half value layer (HVL) calculation was made using the anode and filter material. A range of the HVL values was produced with the addition of small thicknesses of polymethyl methacrylate (PMMA) as a surrogate for the breast compression paddle, to produce a range of HVL values at each tube voltage. Using a spectral weighting method, D(g)N coefficients for the generated spectra were calculated for breast glandular densities of 0%, 12.5%, 25%, 37.5%, 50% and 100% for a range of compressed breast thicknesses from 3 to 8 cm. Eleven tables of normalized glandular dose (D(g)N) coefficients were produced for the following anode/filter combinations: W + 50 μm Ag, W + 500 μm Al, W + 700 μm Al, W + 200 μm Cu, W + 300 μm Cu, W + 50 μm Rh, Mo + 400 μm Cu, Mo + 30 μm Mo, Mo + 25 μm Rh, Rh + 400 μm Cu and Rh + 25 μm Rh. Where possible, these results were compared to previously published D(g)N values and were found to be on average less than 2% different than previously reported values.Over 200 pages of D(g)N coefficients were computed for modeled x-ray system spectra that are used in a number of new breast imaging applications. The reported values were found to be in excellent agreement when compared to published values.

  5. EFFECTS OF X-RAY BEAM ANGLE AND GEOMETRIC DISTORTION ON WIDTH OF EQUINE THORACOLUMBAR INTERSPINOUS SPACES USING RADIOGRAPHY AND COMPUTED TOMOGRAPHY

    DEFF Research Database (Denmark)

    Djernaes, Julie D.; Nielsen, Jon V.; Berg, Lise C.

    2017-01-01

    study was to determine whether X-ray beam angle has an effect on apparent widths of interspinous spaces. Thoracolumbar spine specimens were collected from six equine cadavers and left-right lateral radiographs and sagittal and dorsal reconstructed computed tomographic (CT) images were acquired...

  6. 工业CT锥束X射线能谱及强度的分布模拟%The Simulation of Cone Beam X-ray Spectrum and Intensity Distribution of X-ray in Industrial CT System

    Institute of Scientific and Technical Information of China (English)

    王玮; 李公平; 潘小东; 王云波

    2014-01-01

    In this paper,the physical process of producing X-rays in the X-ray source used in cone-beam industrial CT system was simulated by Monte Carlo method.The X-ray spectrums with and with no 2 mm iron as filter layers were obtained,respectively.In addition,the angular distribution of the outgoing X-ray flux under different target angles was calculated.Then,the intensity distribution of the X-rays which passed through the obj ect under test was simulated.We obtain the distribution of SPR value and the distribution of X-ray intensity in different positions of the detector plane in different conditions,which are in the same distance between the ray source and the detector and passing through the object of the same diameter.Besides,we also obtain the flux spectrum distribution in the centre of detector and the spatial distribution of the X-ray intensity in some special position.The simulation results in this paper can provide some help and basis for the scatter correction and beam hardening correction in the process of image reconstruction and help to determine the minimum sensitivity of the detector,and provide a reference for the shielding system design.%利用蒙特卡罗方法模拟了锥束工业CT系统中X射线的产生过程,分别得到了未加过滤层和加2 mm铁片作为过滤层情况下的X射线能谱;计算了不同靶面倾角下出射X射线相对强度的角分布。随后模拟了X射线通过被测物体后射线强度的分布,分别得到了射线源与探测器间距离相同时,穿过不同直径被测物体以及经过相同的被测物体,但射线源与探测器间距离不同的两种情况下的系统SPR值的分布以及探测器平面不同位置下射线强度的分布。此外还模拟得到了有无被测物体情况下的探测器中心位置的通量能谱分布及一些特殊位置下射线强度的空间分布。模拟结果可以为CT系统图像重建时的散射校正和射束硬化校正提供数据依据,有助于

  7. Characterization of Scattered X-Ray Photons in Dental Cone-Beam Computed Tomography.

    Directory of Open Access Journals (Sweden)

    Ching-Ching Yang

    Full Text Available Scatter is a very important artifact causing factor in dental cone-beam CT (CBCT, which has a major influence on the detectability of details within images. This work aimed to improve the image quality of dental CBCT through scatter correction.Scatter was estimated in the projection domain from the low frequency component of the difference between the raw CBCT projection and the projection obtained by extrapolating the model fitted to the raw projections acquired with 2 different sizes of axial field-of-view (FOV. The function for curve fitting was optimized by using Monte Carlo simulation. To validate the proposed method, an anthropomorphic phantom and a water-filled cylindrical phantom with rod inserts simulating different tissue materials were scanned using 120 kVp, 5 mA and 9-second scanning time covering an axial FOV of 4 cm and 13 cm. The detectability of the CT image was evaluated by calculating the contrast-to-noise ratio (CNR.Beam hardening and cupping artifacts were observed in CBCT images without scatter correction, especially in those acquired with 13 cm FOV. These artifacts were reduced in CBCT images corrected by the proposed method, demonstrating its efficacy on scatter correction. After scatter correction, the image quality of CBCT was improved in terms of target detectability which was quantified as the CNR for rod inserts in the cylindrical phantom.Hopefully the calculations performed in this work can provide a route to reach a high level of diagnostic image quality for CBCT imaging used in oral and maxillofacial structures whilst ensuring patient dose as low as reasonably achievable, which may ultimately make CBCT scan a reliable and safe tool in clinical practice.

  8. Hard alpha-keratin degradation inside a tissue under high flux X-ray synchrotron micro-beam: a multi-scale time-resolved study.

    Science.gov (United States)

    Leccia, Emilie; Gourrier, Aurélien; Doucet, Jean; Briki, Fatma

    2010-04-01

    X-rays interact strongly with biological organisms. Synchrotron radiation sources deliver very intense X-ray photon fluxes within micro- or submicro cross-section beams, resulting in doses larger than the MGy. The relevance of synchrotron radiation analyses of biological materials is therefore questionable since such doses, million times higher than the ones used in radiotherapy, can cause huge damages in tissues, with regard to not only DNA, but also proteic and lipid organizations. Very few data concerning the effect of very high X-ray doses in tissues are available in the literature. We present here an analysis of the structural phenomena which occur when the model tissue of human hair is irradiated by a synchrotron X-ray micro-beam. The choice of hair is supported by its hierarchical and partially ordered keratin structure which can be analysed inside the tissue by X-ray diffraction. To assess the damages caused by hard X-ray micro-beams (1 microm(2) cross-section), short exposure time scattering SAXS/WAXS patterns have been recorded at beamline ID13 (ESRF) after various irradiation times. Various modifications of the scattering patterns are observed, they provide fine insight of the radiation damages at various hierarchical levels and also unexpectedly provide information about the stability of the various hierarchical structural levels. It appears that the molecular level, i.e. the alpha helices which are stabilized by hydrogen bonds and the alpha-helical coiled coils which are stabilized by hydrophobic interactions, is more sensitive to radiation than the supramolecular architecture of the keratin filament and the filament packing within the keratin associated proteins matrix, which is stabilized by disulphide bonds.

  9. Development of an x-ray Talbot-Lau moire deflectometer for fast density profile measurements of dense plasmas generated by beam-target interactions

    Energy Technology Data Exchange (ETDEWEB)

    Clayton, Dan [National Security Technol., LLC, Los Alamos, NM (United States); Berninger, M; Meidinger, A; Stutman, Dan; Valdivia, Maria Pia

    2015-05-01

    For the first time an x-ray Talbot-Lau moire deflectometer is being developed that will use a flash tube source and fast detector for dynamic density gradient measurements. In Talbot-Lau moire deflectometry, an x-ray grating makes an image of itself on a second grating (the Talbot effect) to produce a moire pattern on a detector. The test object is placed between these gratings, with variations in index of refraction changing the pattern. A third grating in front of an incoherent x-ray source produces an array of coherent sources. With a 150 kV x-ray flash tube as the source, the gratings are placed in a glancing angle setup for performance at ~60 keV. The detector is a gated CCD with a fast scintillator for x-ray conversion. This diagnostic, designed for the Dual-Axis Radiographic Hydrodynamic Test facility (DARHT) at Los Alamos National Laboratory, measures the density profile of dense plasma plumes ejected from beam-target interactions. DARHT has two high-current, pulsed, inductive linear electron accelerators with bremsstrahlung targets at the end of each beam line to create 2-D radiographic images of hydrodynamic tests. One multi-pulse accelerator has up to four beam pulses striking the same target within 2 μs. Computer simulations that model target evolution and ejected material between pulses are used to design these targets for optimal radiographic performance; the x-ray deflectometer will directly measure density gradients in the ejected plumes and provide the first experimental constraints to these models. During the first year, currently underway, the diagnostic systems are being designed. In year two, the flash tube and fast detector will be deployed at DARHT for radiographic imaging while the deflectometer is built and tested on the bench with a continuous source. Finally, in year three, the fast deflectometer will be installed on DARHT and density measurements will be performed.

  10. Skull x-ray

    Science.gov (United States)

    X-ray - head; X-ray - skull; Skull radiography; Head x-ray ... There is low radiation exposure. X-rays are monitored and regulated to provide the minimum amount of radiation exposure needed to produce the image. Most ...

  11. Neck x-ray

    Science.gov (United States)

    X-ray - neck; Cervical spine x-ray; Lateral neck x-ray ... There is low radiation exposure. X-rays are monitored so that the lowest amount of radiation is used to produce the image. Pregnant women and ...

  12. 50 μm pixel pitch wafer-scale CMOS active pixel sensor x-ray detector for digital breast tomosynthesis.

    Science.gov (United States)

    Zhao, C; Konstantinidis, A C; Zheng, Y; Anaxagoras, T; Speller, R D; Kanicki, J

    2015-12-07

    Wafer-scale CMOS active pixel sensors (APSs) have been developed recently for x-ray imaging applications. The small pixel pitch and low noise are very promising properties for medical imaging applications such as digital breast tomosynthesis (DBT). In this work, we evaluated experimentally and through modeling the imaging properties of a 50 μm pixel pitch CMOS APS x-ray detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). A modified cascaded system model was developed for CMOS APS x-ray detectors by taking into account the device nonlinear signal and noise properties. The imaging properties such as modulation transfer function (MTF), noise power spectrum (NPS), and detective quantum efficiency (DQE) were extracted from both measurements and the nonlinear cascaded system analysis. The results show that the DynAMITe x-ray detector achieves a high spatial resolution of 10 mm(-1) and a DQE of around 0.5 at spatial frequencies  CMOS APS x-ray detector, image aquisition geometry and image reconstruction techniques should be considered.

  13. Compensating the Electron Beam Energy Spread by the Natural Transverse Gradient of Laser Undulator in All-Optical X-ray Sources

    CERN Document Server

    Zhang, Tong; Deng, Haixiao; Wang, Dong; Dai, Zhimin; Zhao, Zhentang

    2013-01-01

    All-optical schemes provide a potential to dramatically cut off the size and cost of x-ray light sources to the university-laboratory scale, with the combination of the laser-plasma accelerator and the laser undulator. However, the large longitudinal energy spread of the electron beam from laser-plasma accelerator may hinder the way to high brightness of these all-optical light sources. In this letter, the beam energy spread effect is proposed to be significantly compensated by the natural transverse gradient of a laser undulator when properly dispersing the electron beam transversely. Theoretical analysis and numerical simulations on conventional laser-Compton scattering sources and high-gain all-optical x-ray free-electron lasers with the electron beams from laser-plasma accelerators are presented.

  14. Observation of strong virtual scattering under three-beam (220, 371) X-ray diffraction in TeO{sub 2} single crystal

    Energy Technology Data Exchange (ETDEWEB)

    Blagov, A. E.; Kovalchuk, M. V. [Russian Academy of Sciences, Shubnikov Institute of Crystallography (Russian Federation); Kohn, V. G. [Kurchatov Institute, Russian Research Centre (Russian Federation); Pisarevskii, Yu. V.; Prosekov, P. A., E-mail: aopt@ns.crys.ras.ru [Russian Academy of Sciences, Shubnikov Institute of Crystallography (Russian Federation)

    2010-01-15

    A strong effect of virtual scattering has been experimentally observed when studying the nearly coplanar three-beam (220, 371) X-ray diffraction in a paratellurite single crystal under high-resolution double-crystal X-ray diffraction using MoK{sub {alpha}1} radiation. One characteristic feature of this effect is that the angular dependence of the first (strong) reflection intensity and its shape barely change in the three-beam range of parameters, whereas very strong changes are observed for the second (weak) reflection not only in the three-beam range but also far beyond it, which is related to the variation in the two-beam diffraction parameter due to virtual scattering. The changes observed are asymmetric and make it possible to determine the triplet combination of structure-factor phases.

  15. Determination of the ReA Electron Beam Ion Trap electron beam radius and current density with an X-ray pinhole camera

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Thomas M., E-mail: baumannt@nscl.msu.edu; Lapierre, Alain, E-mail: lapierre@nscl.msu.edu; Kittimanapun, Kritsada; Schwarz, Stefan; Leitner, Daniela; Bollen, Georg [National Superconducting Cyclotron Laboratory (NSCL), Michigan State University (MSU), 640 S. Shaw Lane, East Lansing, Michigan, 48824 (United States)

    2014-07-15

    The Electron Beam Ion Trap (EBIT) of the National Superconducting Cyclotron Laboratory at Michigan State University is used as a charge booster and injector for the currently commissioned rare isotope re-accelerator facility ReA. This EBIT charge breeder is equipped with a unique superconducting magnet configuration, a combination of a solenoid and a pair of Helmholtz coils, allowing for a direct observation of the ion cloud while maintaining the advantages of a long ion trapping region. The current density of its electron beam is a key factor for efficient capture and fast charge breeding of continuously injected, short-lived isotope beams. It depends on the radius of the magnetically compressed electron beam. This radius is measured by imaging the highly charged ion cloud trapped within the electron beam with a pinhole camera, which is sensitive to X-rays emitted by the ions with photon energies between 2 keV and 10 keV. The 80%-radius of a cylindrical 800 mA electron beam with an energy of 15 keV is determined to be r{sub 80%}=(212±19)μm in a 4 T magnetic field. From this, a current density of j = (454 ± 83)A/cm{sup 2} is derived. These results are in good agreement with electron beam trajectory simulations performed with TriComp and serve as a test for future electron gun design developments.

  16. Diagnosis of fibroadenoma and breast cancer: ultrasonography vs. X-ray mammography

    Energy Technology Data Exchange (ETDEWEB)

    Song, Jong Gi; Im, Jung gi; Choi, Byung Ihn; Kim, Choo Wan [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1993-12-15

    To evaluate the clinical value of ultrasonography in the diagnosis of fibroadenoma and carcinoma as compared with mammography, we performed a blind retrospective analysis of 85 sonograms and 40 mammograms of 85 breasts that were proved pathologically to have diseases. The lesions included 30 ductal carcinomas, 29 fibroadenomas, 14mammary dysplasias, 2 medullary carcinomas, 1 intraductal papillary carcinoma, and 9 cases of other pathology. The sonograms were reviewed in regards to the border, shape and internal echo pattern of the lesion and the shadows from the margin of the lesion. The mammograms were reviewed in regards to the parenchymal pattern, shape, margin,and calcification of the lesion. The accuracy, sensitivity, and specificity of mammography and ultrasonography in the diagnosis of fibroadenoma were 77%/92%, 40%/93%, and 100%/92%, respectively. The accuracy, sensitivity, and specificity of mammography and ultrasonography in the diagnosis of carcinoma were 85%/85%, 76%/82%, and 91%/86%,respectively. Ultrasonography is more accurate and more sensitive than mammography in the diagnosis offibroadenoma, but not in the diagnosis of carcinoma

  17. The effect of characteristic x-rays on the spatial and spectral resolution of a CZT-based detector for breast CT

    Science.gov (United States)

    Glick, Stephen J.; Didier, Clay S.

    2011-03-01

    In an effort to improve the early stage detection and diagnosis of breast cancer, a number of research groups have been investigating the use of x-ray computerized tomography (CT) systems dedicated for use in imaging the breast. Preliminary results suggest that dedicated breast CT systems can provide improved visualization of 3D breast tissue as compared to conventional mammography. However, current breast CT prototypes that are being investigated have limitations resulting in less than desirable spatial resolution, lesion contrast, and signal-to-noise (SNR) ratio. Another option is a CT breast imaging system that uses a cadmium zinc telluride (CZT) based detector operating in a photon counting mode. This paper uses a Monte Carlo simulation to evaluate the effect of characteristic x-rays on spatial and spectral resolution for a CZT detector used for breast CT. It is concluded that using CZT of 500-750 μm would not cause significant differences in spatial or spectral resolution, nor in stopping power as compared to using CZT with thickness 2-3 mm.

  18. A feasibility study of dynamic stress analysis inside a running internal combustion engine using synchrotron X-ray beams.

    Science.gov (United States)

    Baimpas, Nikolaos; Drakopoulos, Michael; Connolley, Thomas; Song, Xu; Pandazaras, Costas; Korsunsky, Alexander M

    2013-03-01

    The present investigation establishes the feasibility of using synchrotron-generated X-ray beams for time-resolved in situ imaging and diffraction of the interior components of an internal combustion engine during its operation. The demonstration experiment was carried out on beamline I12 (JEEP) at Diamond Light Source, UK. The external hutch of the JEEP instrument is a large-scale engineering test bed for complex in situ processing and simulation experiments. The hutch incorporates a large capacity translation and rotation table and a selection of detectors for monochromatic and white-beam diffraction and imaging. These capabilities were used to record X-ray movies of a motorcycle internal combustion engine running at 1850 r.p.m. and to measure strain inside the connecting rod via stroboscopic X-ray diffraction measurement. The high penetrating ability and high flux of the X-ray beam at JEEP allowed the observation of inlet and outlet valve motion, as well as that of the piston, connecting rod and the timing chain within the engine. Finally, the dynamic internal strain within the moving connecting rod was evaluated with an accuracy of ~50 × 10(-6).

  19. Characterisation of edgeless technologies for pixellated and strip silicon detectors with a micro-focused X-ray beam

    Science.gov (United States)

    Bates, R.; Blue, A.; Christophersen, M.; Eklund, L.; Ely, S.; Fadeyev, V.; Gimenez, E.; Kachkanov, V.; Kalliopuska, J.; Macchiolo, A.; Maneuski, D.; Phlips, B. F.; Sadrozinski, H. F.-W.; Stewart, G.; Tartoni, N.; Zain, R. M.

    2013-01-01

    Reduced edge or ``edgeless'' detector design offers seamless tileability of sensors for a wide range of applications from particle physics to synchrotron and free election laser (FEL) facilities and medical imaging. Combined with through-silicon-via (TSV) technology, this would allow reduced material trackers for particle physics and an increase in the active area for synchrotron and FEL pixel detector systems. In order to quantify the performance of different edgeless fabrication methods, 2 edgeless detectors were characterized at the Diamond Light Source using an 11 μm FWHM 15 keV micro-focused X-ray beam. The devices under test were: a 150 μm thick silicon active edge pixel sensor fabricated at VTT and bump-bonded to a Medipix2 ROIC; and a 300 μm thick silicon strip sensor fabricated at CIS with edge reduction performed by SCIPP and the NRL and wire bonded to an ALiBaVa readout system. Sub-pixel resolution of the 55 μm active edge pixels was achieved. Further scans showed no drop in charge collection recorded between the centre and edge pixels, with a maximum deviation of 5% in charge collection between scanned edge pixels. Scans across the cleaved and standard guard ring edges of the strip detector also show no reduction in charge collection. These results indicate techniques such as the scribe, cleave and passivate (SCP) and active edge processes offer real potential for reduced edge, tiled sensors for imaging detection applications.

  20. Identification of human breast pathologies by X-ray elastic scattering; Identificacao de patologias mamarias atraves do espalhamento elastico de raios X

    Energy Technology Data Exchange (ETDEWEB)

    Conceicao, Andre L.C.; Antoniassi, Marcelo; Poletti, Martin E., E-mail: andre_conceicao@yahoo.com.b [Universidade de Sao Paulo (FFCLRP/USP), Ribeirao Preto, SP (Brazil). Faculdade de Filosofia, Ciencias e Letras. Dept. de Fisica e Matematica

    2011-07-01

    In this paper we determine the scattering profiles of normal, benign and malignant human breast samples in a momentum transfer range of 0.07nm{sup -1} {<=}q{<=}70.55nm{sup -1}, resulted from combining WAXS (wide angle x-ray scattering) and SAXS (small angle x-ray scattering) data. The results showed considerable differences between the scattering profiles of each tissue type. Based on this fact, some parameters, representing structural features, were extracted from these scattering profiles and submitted to a discriminant analysis. From statistical analysis, the ratio between the peak intensities at q=19.8nm{sup -1} and q=13.9nm{sup -1} and the intensity of third order axial collagen peak arose as two potentials breast tissue classifiers and, from combining them it was possible differentiate among normal, benign and malignant lesions. (author)

  1. Molecular-beam epitaxy growth and structural characterization of semiconductor-ferromagnet heterostructures by grazing incidence X-ray diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Satapathy, D.K.

    2005-12-19

    The present work is devoted to the growth of the ferromagnetic metal MnAs on the semiconductor GaAs by molecular-beam epitaxy (MBE). The MnAs thin films are deposited on GaAs by molecular-beam epitaxy (MBE). Grazing incidence diffraction (GID) and reflection high-energy electron diffraction (RHEED) are used in situ to investigate the nucleation, evolution of strain, morphology and interfacial structure during the MBE growth. Four stages of the nucleation process during growth of MnAs on GaAs(001) are revealed by RHEED azimuthal scans. GID shows that further growth of MnAs films proceed via the formation of relaxed islands at a nominal thickness of 2.5 ML which increase in size and finally coalesce to form a continuous film. Early on, an ordered array of misfit dislocations forms at the interface releasing the misfit strain even before complete coalescence occurs. The fascinating complex nucleation process of MnAs on GaAs(0 0 1) contains elements of both Volmer-Weber and Stranski-Krastanov growth. A nonuniform strain amounting to 0.66%, along the [1 -1 0] direction and 0.54%, along the [1 1 0] direction is demonstrated from x-ray line profile analysis. A high correlation between the defects is found along the GaAs[1 1 0] direction. An extremely periodic array of misfit dislocations with a period of 4.95{+-}0.05 nm is formed at the interface along the [1 1 0] direction which releases the 7.5% of misfit. The inhomogeneous strain due to the periodic dislocations is confined at the interface within a layer of 1.6 nm thickness. The misfit along the [1 -1 0] direction is released by the formation of a coincidence site lattice. (orig.)

  2. Comparative study on X- ray mammography and MRI in diagnosing breast cancer%乳腺癌X线与MRI诊断价值比较分析

    Institute of Scientific and Technical Information of China (English)

    渠红; 鲍春生; 邢丽

    2011-01-01

    目的:比较X线及MRI两种影像学检查方法对于乳腺癌的诊断价值.方法:回顾分析48例经手术病理证实的乳腺癌患者的MRI及X线检查资料,进行对比分析.结果:MRI对于乳腺癌病灶的检出高于X线摄影,但存在假阳性,对于判断病变范围及淋巴结转移等方面MRI具有较大价值.结论:X线摄影与MRI联合应用有助于提高乳腺癌的诊断准确率.%Objective:To compare the capabilities of MRI and X - ray mammography in diagnosing breast cancer. Methods ; A retrospective study of 48 breast cancer proved by pathology was performed, the diagnosing results of MRI and X - ray mammography were compared with that of histopathology.Results : MRI imaging was superior to mammography , but it exist false - positive ; MRI imaging was much valuable for lymph nodes metastases and assesament of lesion extent.Conclusion : X - ray mammography in combination with MRI is helpful in the diagnasis of breast cancer ,the sensitivity and specificity was enhanced when compared to that of single.

  3. Tissue Visualization Using X-Ray Dark-Field Imaging towards Pathological Goal

    Science.gov (United States)

    Ando, Masami; Chikaura, Yoshinori; Endo, Tokiko; Gupta, Rajiv; Huo, Qingkai; Hyodo, Kazuyuki; Ichihara, Shu; Mori, Kensaku; Nakao, Yuki; Ohura, Norihiko; Sunaguchi, Naoki; Sugiyama, Hiroshi; Suzuki, Yoshifumi; Wu, Yanlin; Yuasa, Tetsuya; Xiaowei, Zhang

    2013-03-01

    In XDFI (x-ray dark-field imaging) LAA (Laue-case angle analyzer) simultaneously provides two x-ray images; one corresponds to a FD forward diffracted beam and a separate D diffracted beam. When this is applied to biomedical specimens x-ray images are very high contrast and very high spatial resolution. We constructed XDFI system at the vertical wiggler beamline BL-14C in KEK Photon Factory and performed imaging experiment of breast tissues and an excised human femoral artery. In this paper, we discuss a tissue visualization and pathological goal using 2D, 3D-CT and 2.5D image (tomosynthesis) with XDFI.

  4. High Energy Laboratory Astrophysics using an X-Ray Microcalorimeter with an Electron Beam Ion Trap Project

    Data.gov (United States)

    National Aeronautics and Space Administration — "Since the summer of 2000 we have successfully deployed a high resolution x-ray microcalorimeter spectrometer, based on the spaceflight XRS instrument, at the...

  5. Efficient focusing of 8 keV X-rays with multilayer Fresnel zone plates fabricated by atomic layer deposition and focused ion beam milling.

    Science.gov (United States)

    Mayer, Marcel; Keskinbora, Kahraman; Grévent, Corinne; Szeghalmi, Adriana; Knez, Mato; Weigand, Markus; Snigirev, Anatoly; Snigireva, Irina; Schütz, Gisela

    2013-05-01

    Fresnel zone plates (FZPs) recently showed significant improvement by focusing soft X-rays down to ~10 nm. In contrast to soft X-rays, generally a very high aspect ratio FZP is needed for efficient focusing of hard X-rays. Therefore, FZPs had limited success in the hard X-ray range owing to difficulties of manufacturing high-aspect-ratio zone plates using conventional techniques. Here, employing a method of fabrication based on atomic layer deposition (ALD) and focused ion beam (FIB) milling, FZPs with very high aspect ratios were prepared. Such multilayer FZPs with outermost zone widths of 10 and 35 nm and aspect ratios of up to 243 were tested for their focusing properties at 8 keV and shown to focus hard X-rays efficiently. This success was enabled by the outstanding layer quality thanks to ALD. Via the use of FIB for slicing the multilayer structures, desired aspect ratios could be obtained by precisely controlling the thickness. Experimental diffraction efficiencies of multilayer FZPs fabricated via this combination reached up to 15.58% at 8 keV. In addition, scanning transmission X-ray microscopy experiments at 1.5 keV were carried out using one of the multilayer FZPs and resolved a 60 nm feature size. Finally, the prospective of different material combinations with various outermost zone widths at 8 and 17 keV is discussed in the light of the coupled wave theory and the thin-grating approximation. Al2O3/Ir is outlined as a promising future material candidate for extremely high resolution with a theoretical efficiency of more than 20% for as small an outermost zone width as 10 nm at 17 keV.

  6. X-ray production cross-sections measurements for high-energy alpha particle beams: New dedicated set-up and first results with aluminum

    Science.gov (United States)

    Dupuis, T.; Chêne, G.; Mathis, F.; Marchal, A.; Garnir, H.-P.; Strivay, D.

    2011-12-01

    The "IPNAS" laboratory, in collaboration with the "Centre Européen d'Archéométrie" is partly focused on material analysis by means of IBA techniques: PIXE, PIGE and RBS. A new transport beam line has been developed at our CGR-520 MeV cyclotron to analyze Cultural Heritage objects using these techniques. This facility allows us to produce proton and alpha particle beams with energies up to 20 MeV. A vacuum chamber dedicated to X-ray production and Non-Rutherford cross-section measurements has been recently constructed. After determination of the chamber's geometry for X-ray detection using thin foils of several elements (11 ⩽ Z ⩽ 82) and 3 MeV proton beams, the measurement of the X-ray production cross-sections in the 6-12 MeV energy range has started using alpha particle beams on light element targets. These experiments contribute to the filling a serious lack of experimental values for alpha particles of this particular energy range in databases. The recent decision to focus our work on the alpha particle interaction with light elements was taken because of the high interest of the low Z elements in the field of archaeometry.

  7. Nondestructive mapping of chemical composition and structural qualities of group III-nitride nanowires using submicron beam synchrotron-based X-ray diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Bonanno, P.L., E-mail: plb2@njit.edu [Georgia Institute of Technology/GTL, UMI 2958 Georgia Tech-CNRS, 57070 Metz (France); Gautier, S. [LMOPS + UMI: Laboratoire Matériaux Optiques, Photonique et micro-nano Systèmes, UMR CNRS 7132, Université de Metz et SUPELEC, 2 rue E. Belin, 57070 Metz, France, UMI 2958 Georgia Tech-CNRS, 57070 Metz (France); Gmili, Y.El.; Moudakir, T. [UMI 2958 Georgia Tech-CNRS, 57070 Metz (France); Sirenko, A.A. [Department of Physics, New Jersey Institute of Technology, Newark, NJ 07102 (United States); Kazimirov, A. [Cornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, NY 14853 (United States); Cai, Z.-H. [Advanced Photon Source, 9700 S. Cass Avenue, Argonne, IL 60439 (United States); Martin, J. [LMOPS + UMI: Laboratoire Matériaux Optiques, Photonique et micro-nano Systèmes, UMR CNRS 7132, Université de Metz et SUPELEC, 2 rue E. Belin, 57070 Metz, France, UMI 2958 Georgia Tech-CNRS, 57070 Metz (France); Goh, W.H. [Georgia Institute of Technology/GTL, UMI 2958 Georgia Tech-CNRS, 57070 Metz (France); Martinez, A.; Ramdane, A.; Le Gratiet, L. [Laboratoire de Photonique et de Nanostructures, UPR CNRS 20, Route de Nozay, 91460 Marcoussis (France); Maloufi, N. [Laboratoire d' Etude des Textures et Application aux Matériaux UMR CNRS 7078 Ile du Saulcy 57045 METZ cedex 1 (France); Assouar, M.B. [Laboratoire de Physique des Milieux Ionisés et Applications, Nancy University, CNRS, BP 239, F-54506 Vandoeuvre-lès-Nancy Cédex (France); Ougazzaden, A. [Georgia Institute of Technology/GTL, UMI 2958 Georgia Tech-CNRS, 57070 Metz (France)

    2013-08-31

    Submicron beam synchrotron-based X-ray diffraction (XRD) techniques have been developed and used to accurately and nondestructively map chemical composition and material quality of selectively grown group III-nitride nanowires. GaN, AlGaN, and InGaN multi-quantum-well nanowires have been selectively grown on lattice matched and mismatched substrates, and the challenges associated with obtaining and interpreting submicron beam XRD results are addressed and solved. Nanoscale cathodoluminescence is used to examine exciton behavior, and energy-dispersive X-ray spectroscopy is used to verify chemical composition. Scanning transmission electron microscopy is later used to paint a more complete picture. The advantages of submicron beam XRD over other techniques are discussed in the context of this challenging material system. - Highlights: ► We used nano selective area growth to create nanowires of GaN, AlGaN and InGaN/GaN. ► We characterized them by synchrotron-based submicron beam X-ray diffraction (XRD). ► This technique accurately determined chemical and crystallographic properties. ► Challenges of XRD are addressed in the context of this challenging material system. ► Advantages of XRD over other characterization methods are discussed.

  8. X-ray production cross-sections measurements for high-energy alpha particle beams: New dedicated set-up and first results with aluminum

    Energy Technology Data Exchange (ETDEWEB)

    Dupuis, T., E-mail: T.Dupuis@ulg.ac.be [Centre Europeen d' Archeometrie, Atomique et Spectroscopie, Universite de Liege, Sart Tilman B15, B-4000 Liege (Belgium); Institut de Physique Nucleaire, Atomique et Spectroscopie, Universite de Liege, Sart Tilman B15, B-4000 Liege (Belgium); Chene, G., E-mail: Gregoire.Chene@ulg.ac.be [Centre Europeen d' Archeometrie, Atomique et Spectroscopie, Universite de Liege, Sart Tilman B15, B-4000 Liege (Belgium); Institut de Physique Nucleaire, Atomique et Spectroscopie, Universite de Liege, Sart Tilman B15, B-4000 Liege (Belgium); Mathis, F., E-mail: Francois.Mathis@ulg.ac.be [Centre Europeen d' Archeometrie, Atomique et Spectroscopie, Universite de Liege, Sart Tilman B15, B-4000 Liege (Belgium); Institut de Physique Nucleaire, Atomique et Spectroscopie, Universite de Liege, Sart Tilman B15, B-4000 Liege (Belgium); and others

    2011-12-15

    The 'IPNAS' laboratory, in collaboration with the 'Centre Europeen d'Archeometrie' is partly focused on material analysis by means of IBA techniques: PIXE, PIGE and RBS. A new transport beam line has been developed at our CGR-520 MeV cyclotron to analyze Cultural Heritage objects using these techniques. This facility allows us to produce proton and alpha particle beams with energies up to 20 MeV. A vacuum chamber dedicated to X-ray production and Non-Rutherford cross-section measurements has been recently constructed. After determination of the chamber's geometry for X-ray detection using thin foils of several elements (11 Less-Than-Or-Slanted-Equal-To Z Less-Than-Or-Slanted-Equal-To 82) and 3 MeV proton beams, the measurement of the X-ray production cross-sections in the 6-12 MeV energy range has started using alpha particle beams on light element targets. These experiments contribute to the filling a serious lack of experimental values for alpha particles of this particular energy range in databases. The recent decision to focus our work on the alpha particle interaction with light elements was taken because of the high interest of the low Z elements in the field of archaeometry.

  9. Dose-response curve of EBT, EBT2, and EBT3 radiochromic films to synchrotron-produced monochromatic x-ray beams

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Thomas A. D.; Hogstrom, Kenneth R.; Alvarez, Diane; Matthews, Kenneth L. II; Ham, Kyungmin; Dugas, Joseph P. [Mary Bird Perkins Cancer Center, 4950 Essen Lane, Baton Rouge, Louisiana 70809 and Department of Physics and Astronomy, Louisiana State University and A and M College, 202 Nicholson Hall, Baton Rouge, Louisiana 70803 (United States); Department of Physics and Astronomy, Louisiana State University and A and M College, 202 Nicholson Hall, Baton Rouge, Louisiana 70803 (United States); Center for Advanced Microstructures and Devices, Louisiana State University and A and M College, 6980 Jefferson Highway, Baton Rouge, Louisiana 70806 (United States); Mary Bird Perkins Cancer Center, 4950 Essen Lane, Baton Rouge, Louisiana 70809 and Department of Physics and Astronomy, Louisiana State University and A and M College, 202 Nicholson Hall, Baton Rouge, Louisiana 70803 (United States)

    2012-12-15

    Purpose: This work investigates the dose-response curves of GAFCHROMIC{sup Registered-Sign} EBT, EBT2, and EBT3 radiochromic films using synchrotron-produced monochromatic x-ray beams. EBT2 film is being utilized for dose verification in photoactivated Auger electron therapy at the Louisiana State University Center for Advanced Microstructures and Devices (CAMD) synchrotron facility. Methods: Monochromatic beams of 25, 30, and 35 keV were generated on the tomography beamline at CAMD. Ion chamber depth-dose measurements were used to determine the dose delivered to films irradiated at depths from 0.7 to 8.5 cm in a 10 Multiplication-Sign 10 Multiplication-Sign 10-cm{sup 3} polymethylmethacrylate phantom. AAPM TG-61 protocol was applied to convert measured ionization into dose. Films were digitized using an Epson 1680 Professional flatbed scanner and analyzed using the net optical density (NOD) derived from the red channel. A dose-response curve was obtained at 35 keV for EBT film, and at 25, 30, and 35 keV for EBT2 and EBT3 films. Calibrations of films for 4 MV x-rays were obtained for comparison using a radiotherapy accelerator at Mary Bird Perkins Cancer Center. Results: The sensitivity (NOD per unit dose) of EBT film at 35 keV relative to that for 4-MV x-rays was 0.73 and 0.76 for doses 50 and 100 cGy, respectively. The sensitivity of EBT2 film at 25, 30, and 35 keV relative to that for 4-MV x-rays varied from 1.09-1.07, 1.23-1.17, and 1.27-1.19 for doses 50-200 cGy, respectively. For EBT3 film the relative sensitivity was within 3% of unity for all three monochromatic x-ray beams. Conclusions: EBT and EBT2 film sensitivity showed strong energy dependence over an energy range of 25 keV-4 MV, although this dependence becomes weaker for larger doses. EBT3 film shows weak energy dependence, indicating that it would be a better dosimeter for kV x-ray beams where beam hardening effects can result in large changes in the effective energy.

  10. Optical cone beam tomography of Cherenkov-mediated signals for fast 3D dosimetry of x-ray photon beams in water

    Energy Technology Data Exchange (ETDEWEB)

    Glaser, Adam K., E-mail: Adam.K.Glaser@dartmouth.edu, E-mail: Brian.W.Pogue@dartmouth.edu; Andreozzi, Jacqueline M. [Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755 (United States); Zhang, Rongxiao [Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755 (United States); Pogue, Brian W., E-mail: Adam.K.Glaser@dartmouth.edu, E-mail: Brian.W.Pogue@dartmouth.edu [Thayer School of Engineering and Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755 (United States); Gladstone, David J. [Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03766 (United States)

    2015-07-15

    Purpose: To test the use of a three-dimensional (3D) optical cone beam computed tomography reconstruction algorithm, for estimation of the imparted 3D dose distribution from megavoltage photon beams in a water tank for quality assurance, by imaging the induced Cherenkov-excited fluorescence (CEF). Methods: An intensified charge-coupled device coupled to a standard nontelecentric camera lens was used to tomographically acquire two-dimensional (2D) projection images of CEF from a complex multileaf collimator (MLC) shaped 6 MV linear accelerator x-ray photon beam operating at a dose rate of 600 MU/min. The resulting projections were used to reconstruct the 3D CEF light distribution, a potential surrogate of imparted dose, using a Feldkamp–Davis–Kress cone beam back reconstruction algorithm. Finally, the reconstructed light distributions were compared to the expected dose values from one-dimensional diode scans, 2D film measurements, and the 3D distribution generated from the clinical Varian ECLIPSE treatment planning system using a gamma index analysis. A Monte Carlo derived correction was applied to the Cherenkov reconstructions to account for beam hardening artifacts. Results: 3D light volumes were successfully reconstructed over a 400 × 400 × 350 mm{sup 3} volume at a resolution of 1 mm. The Cherenkov reconstructions showed agreement with all comparative methods and were also able to recover both inter- and intra-MLC leaf leakage. Based upon a 3%/3 mm criterion, the experimental Cherenkov light measurements showed an 83%–99% pass fraction depending on the chosen threshold dose. Conclusions: The results from this study demonstrate the use of optical cone beam computed tomography using CEF for the profiling of the imparted dose distribution from large area megavoltage photon beams in water.

  11. Watching adsorption and electron beam induced decomposition on the model system Mo(CO){sub 6}/Cu(1 1 1) by X-ray absorption and photoemission spectroscopies

    Energy Technology Data Exchange (ETDEWEB)

    Paufert, Pierre, E-mail: pierre.paufert@u-bourgogne.fr [ICB, UMR 6303 CNRS-Université de Bourgogne, BP 47870, 21078 Dijon cedex (France); Fonda, Emiliano [Synchrotron SOLEIL, BP48, St Aubin, 91192 Gif sur Yvette cedex (France); Li, Zheshen [ISA, University of Aarhus, Ny Munkegade, DK-8000 Aarhus C (Denmark); Domenichini, Bruno, E-mail: bruno.domenichini@u-bourgogne.fr [ICB, UMR 6303 CNRS-Université de Bourgogne, BP 47870, 21078 Dijon cedex (France); Bourgeois, Sylvie [ICB, UMR 6303 CNRS-Université de Bourgogne, BP 47870, 21078 Dijon cedex (France)

    2013-11-01

    An in-depth study of the first steps of electron beam assisted growth of Mo from molybdenum hexacarbonyl on Cu(1 1 1) has been carried out exploiting the complementarity of X-ray photoemission and X-ray absorption spectroscopies. Frank van der Merwe (2D) growth mode has been observed for the completion of the two first monolayers of adsorbed molecules through a simple physisorption process. Irradiation of the Mo(CO){sub 6} deposit by 1 keV electron beam induces a modification of molybdenum coordination, the average number of C-neighbors decreasing from 6 to 3. Decomposed molecules remain on the surface after annealing at 520 K and organize themselves, the molybdenum atoms moving in Cu(1 1 1) surface fcc hollow sites. After annealing at 670 K, metallic molybdenum growth begins, if the total amount of adsorbed Mo atoms exceeds 1.2 monolayers.

  12. Watching adsorption and electron beam induced decomposition on the model system Mo(CO)6/Cu(1 1 1) by X-ray absorption and photoemission spectroscopies

    Science.gov (United States)

    Paufert, Pierre; Fonda, Emiliano; Li, Zheshen; Domenichini, Bruno; Bourgeois, Sylvie

    2013-11-01

    An in-depth study of the first steps of electron beam assisted growth of Mo from molybdenum hexacarbonyl on Cu(1 1 1) has been carried out exploiting the complementarity of X-ray photoemission and X-ray absorption spectroscopies. Frank van der Merwe (2D) growth mode has been observed for the completion of the two first monolayers of adsorbed molecules through a simple physisorption process. Irradiation of the Mo(CO)6 deposit by 1 keV electron beam induces a modification of molybdenum coordination, the average number of C-neighbors decreasing from 6 to 3. Decomposed molecules remain on the surface after annealing at 520 K and organize themselves, the molybdenum atoms moving in Cu(1 1 1) surface fcc hollow sites. After annealing at 670 K, metallic molybdenum growth begins, if the total amount of adsorbed Mo atoms exceeds 1.2 monolayers.

  13. TAILORING X-RAY BEAM ENERGY SPECTRUM TO ENHANCE IMAGE QUALITY OF NEW RADIOGRAPHY CONTRAST AGENTS BASED ON GD OR OTHER LANTHANIDES.

    Energy Technology Data Exchange (ETDEWEB)

    DILMANIAN,F.A.; WEINMANN,H.J.; ZHONG,Z.; BACARIAN,T.; RIGON,L.; BUTTON,T.M.; REN,B.; WU,X.Y.; ZHONG,N.; ATKINS,H.L.

    2001-02-17

    Gadovist, a 1.0-molar Gd contrast agent from Schering AG, Berlin Germany, in use in clinical MPI in Europe, was evaluated as a radiography contrast agent. In a collaboration with Brookhaven National Laboratory (BNL), Schering AG is developing several such lanthanide-based contrast agents, while BNL evaluates them using different x-my beam energy spectra. These energy spectra include a ''truly'' monochromatic beam (0.2 keV energy bandwidth) from the National Synchrotron Light Source (NSLS), BNL, tuned above the Gd K-edge, and x-ray-tube beams from different kVp settings and beam filtrations. Radiographs of rabbits' kidneys were obtained with Gadovist at the NSLS. Furthermore, a clinical radiography system was used for imaging rabbits' kidneys comparing Gadovist and Conray, an iodinated contrast agent. The study, using 74 kVp and standard Al beam filter for Conray and 66 kVp and an additional 1.5 mm Cu beam filter for Gadovist, produced comparable images for Gadovist and Conray; the injection volumes were the same, while the radiation absorbed dose for Gadovist was slightly smaller. A bent-crystal silicon monochromator operating in the Laue diffraction mode was developed and tested with a conventional x-ray tube beam; it narrows the energy spectrum to about 4 keV around the anode tungsten's Ku line. Preliminary beam-flux results indicate that the method could be implemented in clinical CT if x-ray tubes with {approximately} twice higher output become available.

  14. 乳腺高频钼靶X线联合乳管镜筛查乳腺癌%Ductoscopy combined X-ray mammography for breast cancer screening

    Institute of Scientific and Technical Information of China (English)

    冯立文; 黄茂伦; 廖女珠; 李誉

    2013-01-01

    Objective Understand shunde Uistrict Foshan City,Guangdong Province in the incidence of breast cancer in women.Methods The joint selectivity ductoscopy examination of the clinical breast examination screening,breast X-ray radiography examination from March 2011 to January 2013,Shunde District,FoShan City,Guangdong Provice,3 600 bladder than 40 years old woman with breast cancer screening.Results Three thousand six hundred women were found in 10 cases of breast cancer,the detection rate of 278/100 000 (10/3 600).Breast clinical examination found 1 313 cases of breast abnormalities,142 cases of breast lumps,nipple discharge line fiberoptic ductoscopy to cheek the 100 cases,X-ray radiography examination of four and more than 72 cases,accounted for a total of 45.19% of the screening population (1 627/3 600).Conclusions Joint ductoscopy X-ray radiography examination of breast cancer screening in the normal population can help to detect early breast cancer,and to provide the basis for early clinical treatment.%目的 了解广东省佛山市顺德区城市妇女乳腺高频钼靶X线联合乳管镜筛查乳腺癌的情况.方法 2011年3月-2013年1月采用临床乳腺检查初筛,以及乳腺高频钼靶X线检查联合选择性乳管镜检查,对广东省佛山市顺德区3 600例40岁以上妇女进行了乳腺癌筛查.结果 3 600例妇女共检出乳腺癌10例,检出率为278/10万(10/3600).乳腺临床检查中发现乳腺异常1 313例、乳腺肿块142例、乳头溢液行乳管镜检查100例;乳腺高频钼靶X线检查4级及以上者72例,总共占筛查人群的45.19%(1 627/3 600).结论 通过乳管镜联合乳腺高频钼靶X线片在正常人群中进行乳腺癌筛查,有助于发现早期乳腺癌,为临床早期治疗提供依据.

  15. Comparative study of two flat-panel x-ray detectors applied to small-animal imaging cone-beam micro-CT

    OpenAIRE

    2008-01-01

    Proceeding of: 2008 IEEE Nuclear Science Symposium Conference Record (NSS '08), Dresden, Germany, 19-25 Oct. 2008 This work compares two different X-ray flat-panel detectors for its use in high-speed, cone-beam CT applied to small-animal imaging. The main differences between these two devices are the scintillators and the achievable frame rate. Both devices have been tested in terms of system linearity, sensitivity, resolution, stability and noise properties, taking into account the dif...

  16. Free-electron laser generation of VUV and x-ray radiation using a conditioned beam and ion-channel focusing

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Li-Hua (Brookhaven National Lab., Upton, NY (United States)); Sessler, A.; Whittum, D.H. (Lawrence Berkeley Lab., CA (United States))

    1991-08-30

    The use of ion-focusing and a conditioned beam greatly enhances FEL gain in the VUV and Soft X-Ray range. The equations governing FEL amplification are derived and results of a linear analysis are noted. Numerical results, including 3D effects and having an order of magnitude improvement in gain, are presented for a 30 {Angstrom} example. 3 refs., 2 figs., 1 tab.

  17. Vertical beam size measurement in the CESR-TA $e^+e^-$ storage ring using x-rays from synchrotron radiation

    CERN Document Server

    Alexander, J P; Conolly, C; Edwards, E; Ehrlichman, M P; Fontes, E; Heltsley, B K; Hopkins, W; Lyndaker, A; Peterson, D P; Rider, N T; Rubin, D L; Savino, J; Seeley, R; Shanks, J; Flanagan, J W

    2013-01-01

    We describe the construction and operation of an x-ray beam size monitor (xBSM), a device measuring $e^+$ and $e^-$ beam sizes in the CESR-TA storage ring using synchrotron radiation. The device can measure vertical beam sizes of $10-100~\\mu$m on a turn-by-turn, bunch-by-bunch basis at $e^\\pm$ beam energies of $\\sim2~$GeV. At such beam energies the xBSM images x-rays of $\\epsilon\\approx$1-10$~$keV ($\\lambda\\approx 0.1-1$ nm) that emerge from a hard-bend magnet through a single- or multiple-slit (coded aperture) optical element onto an array of 32 InGaAs photodiodes with 50$~\\mu$m pitch. Beamlines and detectors are entirely in-vacuum, enabling single-shot beam size measurement down to below 0.1$~$mA ($2.5\\times10^9$ particles) per bunch and inter-bunch spacing of as little as 4$~$ns. At $E_{\\rm b}=2.1 $GeV, systematic precision of $\\sim 1~\\mu$m is achieved for a beam size of $\\sim12~\\mu$m; this is expected to scale as $\\propto 1/\\sigma_{\\rm b}$ and $\\propto 1/E_{\\rm b}$. Achieving this precision requires compr...

  18. Differential phase contrast X-ray imaging system and components

    Science.gov (United States)

    Stutman, Daniel; Finkenthal, Michael

    2014-07-01

    A differential phase contrast X-ray imaging system includes an X-ray illumination system, a beam splitter arranged in an optical path of the X-ray illumination system, and a detection system arranged in an optical path to detect X-rays after passing through the beam splitter.

  19. Differential phase contrast X-ray imaging system and components

    Energy Technology Data Exchange (ETDEWEB)

    Stutman, Daniel; Finkenthal, Michael

    2017-01-31

    A differential phase contrast X-ray imaging system includes an X-ray illumination system, a beam splitter arranged in an optical path of the X-ray illumination system, and a detection system arranged in an optical path to detect X-rays after passing through the beam splitter.

  20. Chest X Ray?

    Science.gov (United States)

    ... this page from the NHLBI on Twitter. Chest X Ray A chest x ray is a fast and painless imaging test ... tissue scarring, called fibrosis. Doctors may use chest x rays to see how well certain treatments are ...

  1. X-Rays

    Science.gov (United States)

    X-rays are a type of radiation called electromagnetic waves. X-ray imaging creates pictures of the inside of ... different amounts of radiation. Calcium in bones absorbs x-rays the most, so bones look white. Fat ...

  2. Medical X-Rays

    Science.gov (United States)

    ... Benefits The discovery of X-rays and the invention of CT represented major advances in medicine. X- ... in X-ray and CT Examinations — X-ray definition, dose measurement, safety precautions, risk, and consideration with ...

  3. Accelerator x-ray sources

    CERN Document Server

    Talman, Richard

    2007-01-01

    This first book to cover in-depth the generation of x-rays in particle accelerators focuses on electron beams produced by means of the novel Energy Recovery Linac (ERL) technology. The resulting highly brilliant x-rays are at the centre of this monograph, which continues where other books on the market stop. Written primarily for general, high energy and radiation physicists, the systematic treatment adopted by the work makes it equally suitable as an advanced textbook for young researchers.

  4. Note: significant increase to the temporal resolution of 2D X-ray detectors using a novel beam chopper system.

    Science.gov (United States)

    Küchemann, Stefan; Mahn, Carsten; Samwer, Konrad

    2014-01-01

    The investigation of short time dynamics using X-ray scattering techniques is commonly limited either by the read out frequency of the detector or by a low intensity. In this paper, we present a chopper system, which can increase the temporal resolution of 2D X-ray detectors by a factor of 13. This technique only applies to amorphous or polycrystalline samples due to their circular diffraction patterns. Using the chopper, we successfully increased the temporal resolution up to 5.1 ms during synchrotron experiments. For the construction, we provide a mathematical formalism, which, in principle, allows an even higher increase of the temporal resolution.

  5. New achievements in X-ray optics——the X-ray lens and its applications

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    An X-ray lens consists of a large number of X-ray capillaries. It can collect divergent X-rays emitted from an X-ray source and form a focused or parallel beam of high intensity. So it is an effective tool for adjusting and controlling wide bandwidth X-ray beams. In this paper, the X-ray lens made by the X-ray Optics Laboratory of Institute of Low Energy Nuclear Physics at Beijing Normal University and its applications in the field of X-ray analysis are presented.

  6. Particle induced X-ray emission and ion dose distribution in a biological micro-beam: Geant4 Monte Carlo simulations

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, Syed Bilal, E-mail: ahmadsb@mcmaster.ca [TAB-104D, Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada L8S 4K1 (Canada); Thompson, Jeroen E., E-mail: Jeroen.thompson@gmail.com [Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada L8S 4K1 (Canada); McNeill, Fiona E., E-mail: fmcneill@mcmaster.ca [Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada L8S 4K1 (Canada); Byun, Soo Hyun, E-mail: soohyun@mcmaster.ca [Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada L8S 4K1 (Canada); Prestwich, William V., E-mail: prestwic@mcmaster.ca [Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada L8S 4K1 (Canada)

    2013-01-15

    The goal of a microbeam is to deliver a highly localized and small dose to the biological medium. This can be achieved by using a set of collimators that confine the charged particle beam to a very small spatial area of the order of microns in diameter. By using a system that combines an appropriate beam detection method that signals to a beam shut-down mechanism, a predetermined and counted number of energetic particles can be delivered to targeted biological cells. Since the shutter and the collimators block a significant proportion of the beam, there is a probability of the production of low energy X-rays and secondary electrons through interactions with the beam. There is little information in the biological microbeam literature on potential X-ray production. We therefore used Monte Carlo simulations to investigate the potential production of particle-induced X-rays and secondary electrons in the collimation system (which is predominantly made of tungsten) and the subsequent possible effects on the total absorbed dose delivered to the biological medium. We found, through the simulation, no evidence of the escape of X-rays or secondary electrons from the collimation system for proton energies up to 3 MeV as we found that the thickness of the collimators is sufficient to reabsorb all of the generated low energy X-rays and secondary electrons. However, if the proton energy exceeds 3 MeV our simulations suggest that 10 keV X-rays can escape the collimator and expose the overlying layer of cells and medium. If the proton energy is further increased to 4.5 MeV or beyond, the collimator can become a significant source of 10 keV and 59 keV X-rays. These additional radiation fields could have effects on cells and these results should be verified through experimental measurement. We suggest that researchers using biological microbeams at higher energies need to be aware that cells may be exposed to a mixed LET radiation field and be careful in their interpretation of

  7. Radioluminescence characterization of in situ x-ray nanodosimeters: Potential real-time monitors and modulators of external beam radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Souris, Jeffrey S.; La Riviere, Patrick; Chen, Chin-Tu [Department of Radiology, The University of Chicago, Chicago, Illinois 60637 (United States); Cheng, Shih-Hsun; Chen, Nai-Tzu; Lo, Leu-Wei, E-mail: lwlo@nhri.org.tw [Department of Radiology, The University of Chicago, Chicago, Illinois 60637 (United States); Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan, Mioli 35053, Taiwan (China); Pelizzari, Charles [Deaprtment of Radiation and Cellular Oncology, The University of Chicago, Chicago, Illinois 60637 (United States)

    2014-11-17

    Europium-doped yttrium oxide (Y{sub 2}O{sub 3}:Eu) has garnered considerable interest recently for its use as a highly efficient, red phosphor in a variety of lighting applications that include fluorescent lamps, plasma, and field emission display panels, light emitting diodes (LEDs), and lasers. In the present work, we describe the development of Y{sub 2}O{sub 3}:Eu nanoparticles for a very different application: in situ, in vivo x-ray dosimetry. Spectroscopic analyses of these nanoparticles during x-ray irradiation reveal surprisingly bright and stable radioluminescence at near-infrared wavelengths, with markedly linear response to changes in x-ray flux and energy. Monte Carlo modeling of incident flux and broadband, wide-field imaging of mouse phantoms bearing both Y{sub 2}O{sub 3}:Eu nanoparticles and calibrated LEDs of similar spectral emission demonstrated significant transmission of radioluminescence, in agreement with spectroscopic studies; with approximately 15 visible photons being generated for every x-ray photon incident. Unlike the dosimeters currently employed in clinical practice, these nanodosimeters can sample both dose and dose rate rapidly enough as to provide real-time feedback for x-ray based external beam radiotherapy (EBRT). The technique's use of remote sensing and absence of supporting structures enable perturbation-free dosing of the targeted region and complete sampling from any direction. With the conjugation of pathology-targeting ligands onto their surfaces, these nanodosimeters offer a potential paradigm shift in the real-time monitoring and modulation of delivered dose in the EBRT of cancer in situ.

  8. Luminescence of yttrium niobium-tantalate doubly activated by europium and/or terbium under X-ray and electron beam excitation

    Energy Technology Data Exchange (ETDEWEB)

    Arellano, I.D., E-mail: arellano@utp.edu.co [Department of Physics, Technological University of Pereira, Vereda La Julita, Pereira (Colombia); Nazarov, M.V. [Institute of Applied Physics, Academy of Sciences of Moldova, Republic of Moldova (Moldova, Republic of); School of Materials and Mineral Resources Engineering Universiti Sains Malaysia, 14300 Nibong Tebal, Penang (Malaysia); Cortes, J.A. [Department of Physics, Technological University of Pereira, Vereda La Julita, Pereira (Colombia); Ahmad Fauzi, M.N [School of Materials and Mineral Resources Engineering Universiti Sains Malaysia, 14300 Nibong Tebal, Penang (Malaysia)

    2012-09-15

    This paper reports the luminescence emission spectra of Y(Ta,Nb)O{sub 4} activated by rare earth ions such as Eu{sup 3+} and Tb{sup 3+}. The influence of these rare earth ions on the luminescence of yttrium niobium-tantalate phosphors was investigated. The luminescent properties were studied under X-ray and electron beam excitations. Under these excitations, the emission centers of the rare earth activators (Eu{sup 3+},Tb{sup 3+}) were found to contribute efficiently to the overall luminescence. Changing the mol concentration of the incorporated activators resulted in a broad variation of visible photoluminescence. Color cathodoluminescence images showed clearly the dependence of chromaticity on the different activators. With their various luminescence chromaticities, these rare earth activated phosphors are promising materials for solid-state lighting applications as well as for X-ray intensifying screens in medical diagnosis, providing a broad variation of visible photoluminescence from blue to red. - Highlights: Black-Right-Pointing-Pointer The Y(Ta,Nb)O{sub 4} phosphors were activated by rare earth ions such as Eu{sup 3+} and Tb{sup 3+}. Black-Right-Pointing-Pointer The phosphors were studied under X-ray and electron beam excitations. Black-Right-Pointing-Pointer The emission centers contribute efficiently to the overall luminescence. Black-Right-Pointing-Pointer Changing the concentration of the activators resulted in a broad luminescence.

  9. Material-specific imaging system using energy-dispersive X-ray diffraction and spatially resolved CdZnTe detectors with potential application in breast imaging

    Science.gov (United States)

    Barbes, Damien; Tabary, Joachim; Paulus, Caroline; Hazemann, Jean-Louis; Verger, Loïck

    2017-03-01

    This paper presents a coherent X-ray-scattering imaging technique using a multipixel energy-dispersive system. Without any translation, the technique produces specific 1D image from data recorded by a single CdZnTe detector pixel using subpixelation techniques. The method is described in detail, illustrated by a simulation and then experimentally validated. As the main considered application of our study is breast imaging, this validation involves 2D imaging of a phantom made of plastics mimicking breast tissues. The results obtained show that our system can specifically image the phantom using a single detector pixel. For the moment, in vivo breast imaging applications remain difficult, as the dose delivered by the system is too high, but some adjustments are considered for further work.

  10. Cross-calibration of pencil-beam (DPX-NT) and fan-beam (QDR-4500C) dual-energy X-ray absorptiometry for sarcopenia.

    Science.gov (United States)

    Ito, Kenyu; Tsushita, Kazuyo; Muramoto, Akiko; Kanzaki, Hiroki; Nohara, Takashi; Shimizu, Hitomi; Nakazawa, Tomoko; Harada, Atsushi

    2015-11-01

    Sarcopenia, defined as the loss of muscle mass accompanied by weakness, is an important factor leading to frailty and is a growing concern in the aging Japanese society. Muscle mass can be calculated by dual-energy X-ray absorptiometry (DXA), but results differ between devices produced by different manufactures. Thus, cross-calibration is needed to compare body composition results in multicenter trials or when scanners are replaced. The purpose of this study was to perform an in vivo calibration of total body scans between pencil-beam (DPX-NT, GE Healthcare) and fan-beam (QDR-4500C, Hologic Inc.) DXA units. A total 30 subjects (15 women, 15 men, mean age = 35 years, range 22-49 years) were recruited. The lumbar bone mineral density (BMD), femoral neck BMD, appendicular fat and lean body mass, and the appendicular skeletal muscle mass index (ASMI) were highly correlated (r = 0.979-0.993, r(2) = 0.889-0.977). The conversion formulas were as follows: lumbar BMD, Y = -0.08 + 1.16X (X = QDR-4500C, Y = DPX-NT), femoral neck BMD, Y = -0.015 + 1.11X, and ASMI Y = 0.92 + 0.90X. There is excellent comparability between the DPX-NT and the QDR-4500C DXA units. However, cross-calibration equations are required to assess muscle volume, fat, and ASMI in multicenter studies investigating sarcopenia.

  11. QED-based Optical Bloch Equations without electric dipole approximation: A model for a two-level atom interacting with a monochromatic X-ray laser beam

    CERN Document Server

    Zhang, Wen-Zhuo

    2012-01-01

    We derive a set of optical Bloch equations (OBEs) directly from the minimal-coupling Hamiltonian density of the bound-state quantum electrodynamics (bound-state QED). Such optical Bloch equations are beyond the former widely-used ones due to that there is no electric dipole approximation (EDA) on the minimal-coupling Hamiltonian density of the bound-state QED. Then our optical Bloch equations can describe a two-level atom interacting with a monochromatic light of arbitrary wavelength, which are suitable to study the spectroscopy and the Rabi oscillations of two-level atoms in X-ray laser beams since that the wavelength of X-ray is close to an atom to make the electric dipole approximation (EDA) invalid.

  12. Interfacial structure of molecular beam epitaxial grown cubic-GaN films on GaAs(001) probed by x-ray gazing-angle specular reflection

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    We report on a study of interfacial structure of GaN films grown on GaAs(001) substrates by plasma-assisted molecular beam epitaxy using x-ray grazing-angle specular reflection.We show that interfacial layers with electron densities differing from those of GaN and GaAs were formed upon deposition of GaN.It is also found that the interfacial structure of our systems depends strongly on the course of the initial layer deposition.The phase purity of the GaN films was examined by x-ray reciprocal space mapping.A simple kinetic growth model suggested by our results has been presented.

  13. X-ray Examination of the Breast Quality Control Explore%乳腺X线检查的质量控制探究

    Institute of Scientific and Technical Information of China (English)

    张学勤; 汪秀玲; 刘洪

    2014-01-01

    Objective To evaluate the quality control of X-ray examination of the breast. Methods Summed up the work of the breast X-ray examination of the process, position, quality control. Result The photographic work of preparation, position selection, patient notes and post-image processing and other mat ers is essential to the quality of management control. Conclusion Establishing quality assurance standards, diagnosis and treatment of breast disease is the basic guarantee.%目的:探讨乳腺X线检查的质量控制。方法总结了作者工作中的乳腺X线检查的流程,体位,注意事项等质控事项。结果工作中的摄影准备,体位选择,患者注意事项及图像后处理等事项对乳腺X线的质量管理控制至关重要。结论建立乳腺质量保证标准,是乳腺疾病的诊治工作基本保证。

  14. 乳腺X线检查的质量控制探究%Quality Control of Breast X-ray Examination

    Institute of Scientific and Technical Information of China (English)

    张学勤; 汪秀玲; 刘洪

    2014-01-01

    Objective To evaluate the quality control of X-ray examination of the breast. Methods Summed up the work of the breast X-ray examination of the process, position, quality control.Results The photographic work of preparation, position selection, patient notes and post-image processing and other mat ers is essential to the quality of management control.Conclusion Establishing quality assurance standards, diagnosis and treatment of breast disease is the basic guarantee.%目的探讨乳腺X线检查的质量控制。方法总结了作者工作中的乳腺X线检查的流程,体位,注意事项等质控事项。结果工作中的摄影准备,体位选择,病人注意事项及图像后处理等事项对乳腺X线的质量管理控制至关重要。结论建立乳腺质量保证标准,是乳腺疾病的诊治工作基本保证。

  15. Performance analysis of a CsI-based flat panel detector in a cone beam variable resolution x-ray system

    Science.gov (United States)

    Dahi, Bahram; Keyes, Gary S.; Rendon, David A.; DiBianca, Frank A.

    2007-03-01

    A new Cone-Beam CT (CBCT) system is introduced that uses the concept of Variable Resolution X-ray (VRX) detection, which has previously been demonstrated to significantly increase spatial resolution for small objects. An amorphous silicon Flat Panel Detector (FPD) with a CsI scintillator (PaxScan 2020, Varian, Salt Lake City, UT) is coupled with a micro-focus x-ray tube (35 - 80 kVp, 10 - 250 μA) to form a CBCT. The FPD is installed on a rotating arm that can be adjusted to any angle θ, called the VRX angle, between 90° and 0° with respect to the x-ray direction. A VRX angle of 90° for the detector corresponds to a conventional CBCT whereas a VRX angle of 30° means that the detector is tilted 90° - 30° = 60° from its perpendicular position. Tilting the FPD in this manner reduces both the line-spread function width and the sampling distance by a factor of sin(θ), thereby increasing detector spatial resolution proportionately. An in-house phantom is used to measure the MTF of the reconstructed CT images using different VRX angles. An increase by a factor of 1.67 +/- 0.007 is observed in the MTF cutoff frequency at 30° compared to 90° in images acquired at 75 kVp. Expected theoretical value for this case is 2.0. The new Cone-Beam Variable Resolution X-ray (CB-VRX) CT system is expected to significantly improve the images acquired from small objects - such as small animals - while exploiting the opportunities offered by a conventional CBCT.

  16. Simulation of dark-field imaging of micro-calcifications in human breast tissue with X-ray Talbot-Lau interferometry

    Science.gov (United States)

    Ritter, A.; Anton, G.; Bayer, F.; Gödel, K.; Pelzer, G.; Rieger, J.; Weber, T.; Zang, A.; Michel, T.

    2014-05-01

    A simulation of dark-field imaging of sub-resolution structures with X-ray Talbot-Lau interferometry is presented. Data obtained from the simulation shows good agreement to a signal found in the dark-field image of a surgically removed sample of human breast tissue containing micro calcifications. A measure for the type of micro calcifications is introduced which can be calculated from dark-field signals. In a further analysis of the simulated data, it can be shown that the measure can be used to discriminate between different calcifications types.

  17. X-ray induced formation of γ-H2AX foci after full-field digital mammography and digital breast-tomosynthesis.

    Directory of Open Access Journals (Sweden)

    Siegfried A Schwab

    Full Text Available PURPOSE: To determine in-vivo formation of x-ray induced γ-H2AX foci in systemic blood lymphocytes of patients undergoing full-field digital mammography (FFDM and to estimate foci after FFDM and digital breast-tomosynthesis (DBT using a biological phantom model. MATERIALS AND METHODS: The study complies with the Declaration of Helsinki and was performed following approval by the ethic committee of the University of Erlangen-Nuremberg. Written informed consent was obtained from every patient. For in-vivo tests, systemic blood lymphocytes were obtained from 20 patients before and after FFDM. In order to compare in-vivo post-exposure with pre-exposure foci levels, the Wilcoxon matched pairs test was used. For in-vitro experiments, isolated blood lymphocytes from healthy volunteers were irradiated at skin and glandular level of a porcine breast using FFDM and DBT. Cells were stained against the phosphorylated histone variant γ-H2AX, and foci representing distinct DNA damages were quantified. RESULTS: Median in-vivo foci level/cell was 0.086 (range 0.067-0.116 before and 0.094 (0.076-0.126 after FFDM (p = 0.0004. In the in-vitro model, the median x-ray induced foci level/cell after FFDM was 0.120 (range 0.086-0.140 at skin level and 0.035 (range 0.030-0.050 at glandular level. After DBT, the median x-ray induced foci level/cell was 0.061 (range 0.040-0.081 at skin level and 0.015 (range 0.006-0.020 at glandular level. CONCLUSION: In patients, mammography induces a slight but significant increase of γ-H2AX foci in systemic blood lymphocytes. The introduced biological phantom model is suitable for the estimation of x-ray induced DNA damages in breast tissue in different breast imaging techniques.

  18. On amplitude beam splitting of tender X-rays (2-8 keV photon energy) using conical diffraction from reflection gratings with laminar profile.

    Science.gov (United States)

    Jark, Werner; Eichert, Diane

    2016-01-01

    Conical diffraction is obtained when a radiation beam impinges onto a periodically ruled surface structure parallel or almost parallel to the ruling. In this condition the incident intensity is diffracted through an arc, away from the plane of incidence. The diffracted intensity thus lies on a cone, which leads to the name `conical diffraction'. In this configuration almost no part of the ruled structure will produce any shadowing effect for the incident or the diffracted beam. Then, compared with a grating in the classical orientation, relatively higher diffraction efficiencies will be observed for fewer diffraction orders. When the incident beam is perfectly parallel to the grooves of a rectangular grating profile, the symmetry of the setup causes diffraction of the intensity symmetrically around the plane of incidence. This situation was previously tested experimentally in the VUV spectral range for the amplitude beam splitting of a radiation beam with a photon energy of 25 eV. In this case the ideally expected beam splitting efficiency of about 80% for the diffraction into the two first orders was confirmed for the optimum combination of groove depth and angle of grazing incidence. The feasibility of the amplitude beam splitting for hard X-rays with 12 keV photon energy by use of the same concept was theoretically confirmed. However, no related experimental data are presented yet, not even for lower energy soft X-rays. The present study reports the first experimental data for the conical diffraction from a rectangular grating profile in the tender X-ray range for photon energies of 4 keV and 6 keV. The expected symmetries are observed. The maximum absolute efficiency for beam splitting was measured to be only about 30%. As the reflectivity of the grating coating at the corresponding angle of grazing incidence was found to be only of the order of 50%, the relative beam splitting efficiency was thus 60%. This is to be compared also here with an ideally

  19. Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams

    Energy Technology Data Exchange (ETDEWEB)

    Dilmanian, F. Avraham (Yaphank, NY); Anchel, David J. (Rocky Point, NY); Gaudette, Glenn (Holden, MA); Romanelli, Pantaleo (Monteroduni, IT); Hainfeld, James (Shoreham, NY)

    2010-06-29

    A method of assisting recovery of an injury site of the central nervous system (CNS) or treating a disease includes providing a therapeutic dose of X-ray radiation to a target volume through an array of parallel microplanar beams. The dose to treat CNS injury temporarily removes regeneration inhibitors from the irradiated site. Substantially unirradiated cells surviving between beams migrate to the in-beam portion and assist recovery. The dose may be staggered in fractions over sessions using angle-variable intersecting microbeam arrays (AVIMA). Additional doses are administered by varying the orientation of the beams. The method is enhanced by injecting stem cells into the injury site. One array or the AVIMA method is applied to ablate selected cells in a target volume associated with disease for palliative or curative effect. Atrial fibrillation is treated by irradiating the atrial wall to destroy myocardial cells while continuously rotating the subject.

  20. Search for novel contrast materials in dual-energy x-ray breast imaging using theoretical modeling of contrast-to-noise ratio.

    Science.gov (United States)

    Karunamuni, R; Maidment, A D A

    2014-08-01

    Contrast-enhanced (CE) dual-energy (DE) x-ray breast imaging uses a low- and high-energy x-ray spectral pair to eliminate soft-tissue signal variation and thereby increase the detectability of exogenous imaging agents. Currently, CEDE breast imaging is performed with iodinated contrast agents. These compounds are limited by several deficiencies, including rapid clearance and poor tumor targeting ability. The purpose of this work is to identify novel contrast materials whose contrast-to-noise ratio (CNR) is comparable or superior to that of iodine in the mammographic energy range. A monoenergetic DE subtraction framework was developed to calculate the DE signal intensity resulting from the logarithmic subtraction of the low- and high-energy signal intensities. A weighting factor is calculated to remove the dependence of the DE signal on the glandularity of the breast tissue. Using the DE signal intensity and weighting factor, the CNR for materials with atomic numbers (Z) ranging from 1 to 79 are computed for energy pairs between 10 and 50 keV. A group of materials with atomic numbers ranging from 42 to 63 were identified to exhibit the highest levels of CNR in the mammographic energy range. Several of these materials have been formulated as nanoparticles for various applications but none, apart from iodine, have been investigated as CEDE breast imaging agents. Within this group of materials, the necessary dose fraction to the LE image decreases as the atomic number increases. By reducing the dose to the LE image, the DE subtraction technique will not provide an anatomical image of sufficient quality to accompany the contrast information. Therefore, materials with Z from 42 to 52 provide nearly optimal values of CNR with energy pairs and dose fractions that provide good anatomical images. This work is intended to inspire further research into new materials for optimized CEDE breast functional imaging.

  1. Synchrotron radiation induced x-ray micro analysis: A realistic alternative for electron- and ion beam microscopy?

    Energy Technology Data Exchange (ETDEWEB)

    Janssens, K.; Adams, F. [Universitaire Instelling Antwerpen, Antwerp (Belgium). Dept. of Chemistry; Rivers, M.L.; Jones, K.W. [Brookhaven National Lab., Upton, NY (United States)

    1992-10-01

    Synchrotron Radiation induced X-ray micro Fluorescence analysis ({mu}-SRXRF) is compared with more conventional microanalytical techniques such as Secondary Ion Microscopy (SIMS) and Electron Probe X-ray Microanalysis (EPXMA) for two typical microanalytical applications. SRXRF and EPXMA are employed for the analysis of individual particles, showing the complementary character of both techniques. By means of element mapping of trace constituents in a heterogeneous feldspar, the strong and weak points of SRXRF in comparison to EPXMA and SIMS are illustrated. The most striking difference between SRXRF and the other two microanalytical methods is the ability of SRXRF to probe deep into the investigated Material, whereas SIMS and EPXMA only investigate the upper surface of the material. The possibilities of SRXRF at third generation synchrotron rings is also briefly discussed.

  2. Synchrotron radiation induced x-ray micro analysis: A realistic alternative for electron- and ion beam microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Janssens, K.; Adams, F. (Universitaire Instelling Antwerpen, Antwerp (Belgium). Dept. of Chemistry); Rivers, M.L.; Jones, K.W. (Brookhaven National Lab., Upton, NY (United States))

    1992-01-01

    Synchrotron Radiation induced X-ray micro Fluorescence analysis ([mu]-SRXRF) is compared with more conventional microanalytical techniques such as Secondary Ion Microscopy (SIMS) and Electron Probe X-ray Microanalysis (EPXMA) for two typical microanalytical applications. SRXRF and EPXMA are employed for the analysis of individual particles, showing the complementary character of both techniques. By means of element mapping of trace constituents in a heterogeneous feldspar, the strong and weak points of SRXRF in comparison to EPXMA and SIMS are illustrated. The most striking difference between SRXRF and the other two microanalytical methods is the ability of SRXRF to probe deep into the investigated Material, whereas SIMS and EPXMA only investigate the upper surface of the material. The possibilities of SRXRF at third generation synchrotron rings is also briefly discussed.

  3. Influence of different types of breast X-ray on diagnosis of breast cancer%乳腺 X线不同分型对乳腺癌诊断的影响

    Institute of Scientific and Technical Information of China (English)

    于书奎; 孙男男

    2014-01-01

    目的:分析乳腺X线不同分型对乳腺癌诊断的影像,提高诊断准确性。方法收集本院2010年6月~2013年6月乳腺癌患者共计160例,行模拟乳腺X线摄影系统+CR图像处理,并经手术病理证实为乳腺癌,对不同X线分型与漏诊的情况进行分析。结果乳腺不同X线分型对乳腺癌诊断有影响,检查160例中漏诊9例,3例为致密型,6例为腺纤维型。结论在X线诊断过程中,仔细阅片,注意方法,加强责任心,规范操作,可减少钼靶X线检查的漏诊。%Objective To analyze effect of different types of breast X-ray for breast cancer diagnosis to improve the diagnostic accuracy .Methods Collected 160 cases of breast cancer patients from June 2010 to June 2013 in our hospital to perform line simulation breast X-ray photography system +CR image processing , and diagnosis of breast cancer confirmed by surgery pathology , the situation of different classification and diag-nosis by X-ray analysis .Results different breast X-ray classification had influence on the breast cancer diag-nosis, out of 160 cases, 9 cases of misdiagnosis , 3 cases of dense type , 6 cases of gland fiber type .Conclusion In the process of X-ray diagnosis , reading carefully and paying attention to methods , strengthening the sense of responsibility , standardizing operation can reduce the molybdenum target X-ray in diagnosis .

  4. Conception and realization of a parallel-plate free-air ionization chamber for the absolute dosimetry of an ultrasoft X-ray beam.

    Science.gov (United States)

    Groetz, J-E; Ounoughi, N; Mavon, C; Belafrites, A; Fromm, M

    2014-08-01

    We report the design of a millimeter-sized parallel plate free-air ionization chamber (IC) aimed at determining the absolute air kerma rate of an ultra-soft X-ray beam (E = 1.5 keV). The size of the IC was determined so that the measurement volume satisfies the condition of charged-particle equilibrium. The correction factors necessary to properly measure the absolute kerma using the IC have been established. Particular attention was given to the determination of the effective mean energy for the 1.5 keV photons using the PENELOPE code. Other correction factors were determined by means of computer simulation (COMSOL™ and FLUKA). Measurements of air kerma rates under specific operating parameters of the lab-bench X-ray source have been performed at various distances from that source and compared to Monte Carlo calculations. We show that the developed ionization chamber makes it possible to determine accurate photon fluence rates in routine work and will constitute substantial time-savings for future radiobiological experiments based on the use of ultra-soft X-rays.

  5. Conception and realization of a parallel-plate free-air ionization chamber for the absolute dosimetry of an ultrasoft X-ray beam

    Energy Technology Data Exchange (ETDEWEB)

    Groetz, J.-E., E-mail: jegroetz@univ-fcomte.fr; Mavon, C.; Fromm, M. [Laboratoire Chrono-Environnement, UMR CNRS 6249, Université de Franche-Comté, 16 route de Gray, 25030 Besançon Cedex (France); Ounoughi, N. [Laboratoire Chrono-Environnement, UMR CNRS 6249, Université de Franche-Comté, 16 route de Gray, 25030 Besançon Cedex (France); Laboratoire de Physique des Rayonnements et Applications, Université de Jijel, B.P. 98 Ouled Aissa, Jijel 18000 (Algeria); Belafrites, A. [Laboratoire de Physique des Rayonnements et Applications, Université de Jijel, B.P. 98 Ouled Aissa, Jijel 18000 (Algeria)

    2014-08-15

    We report the design of a millimeter-sized parallel plate free-air ionization chamber (IC) aimed at determining the absolute air kerma rate of an ultra-soft X-ray beam (E = 1.5 keV). The size of the IC was determined so that the measurement volume satisfies the condition of charged-particle equilibrium. The correction factors necessary to properly measure the absolute kerma using the IC have been established. Particular attention was given to the determination of the effective mean energy for the 1.5 keV photons using the PENELOPE code. Other correction factors were determined by means of computer simulation (COMSOL™and FLUKA). Measurements of air kerma rates under specific operating parameters of the lab-bench X-ray source have been performed at various distances from that source and compared to Monte Carlo calculations. We show that the developed ionization chamber makes it possible to determine accurate photon fluence rates in routine work and will constitute substantial time-savings for future radiobiological experiments based on the use of ultra-soft X-rays.

  6. Conception and realization of a parallel-plate free-air ionization chamber for the absolute dosimetry of an ultrasoft X-ray beam

    Science.gov (United States)

    Groetz, J.-E.; Ounoughi, N.; Mavon, C.; Belafrites, A.; Fromm, M.

    2014-08-01

    We report the design of a millimeter-sized parallel plate free-air ionization chamber (IC) aimed at determining the absolute air kerma rate of an ultra-soft X-ray beam (E = 1.5 keV). The size of the IC was determined so that the measurement volume satisfies the condition of charged-particle equilibrium. The correction factors necessary to properly measure the absolute kerma using the IC have been established. Particular attention was given to the determination of the effective mean energy for the 1.5 keV photons using the PENELOPE code. Other correction factors were determined by means of computer simulation (COMSOL™and FLUKA). Measurements of air kerma rates under specific operating parameters of the lab-bench X-ray source have been performed at various distances from that source and compared to Monte Carlo calculations. We show that the developed ionization chamber makes it possible to determine accurate photon fluence rates in routine work and will constitute substantial time-savings for future radiobiological experiments based on the use of ultra-soft X-rays.

  7. SU-E-J-247: A Simulation of X-Ray Emission with Gold Nanoparticle Irradiated by Energetic Proton Beam

    Energy Technology Data Exchange (ETDEWEB)

    Newpower, M; Ahmad, S; Chen, Y [University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States)

    2014-06-01

    Purpose: To investigate the proton induced X-ray emissions in gold-water mixture materials. Methods: In this study a Monte Carlo simulation was created using the GEANT4 toolkit (version 4.9.6). The geometry in this setup includes a 2 cm × 2 cm × 2 cm target, a scoring sphere (radius = 10 cm) and a 65 MeV planar proton source (2 cm × 2 cm). Four concentrations of a gold-water solution were irradiated with 5×10{sup 5} incident protons at a distance of 0.5 cm perpendicular to the surface of the target. The solutions of gold-water mixture had 10%, 5%, 1% and 0.5% of gold by mass, respectively. The number of photon emitting for the target was counted in the scoring sphere for the energy range of 0-86.0 keV in 0.1 keV bins. For this study the reference physics list PhysListEmStandard was used together with the x-ray fluorescence, Auger electron and PIXE (particle induced xray emission) options enabled. The range cuts for photons and electrons were set at 0.5 mm and 1.0 mm, respectively. Results: In the energy spectra of emitting X-ray fluorescence, peaks from gold K shell characteristic x-rays (68.8 and 66.9 keV) were observed. The number of counts under the peaks of Ka1 and Ka2 was found to increase with the increasing of the gold concentrations in the mixture materials. The X-ray yields (for both Ka1 and Ka2) when fitted with least-square method as a function of gold concentration demonstrate a linear dependency with R{sup 2} > 0.96. The Ka1yield per incident proton was found to be 0.0016 for 10% gold-water mixture solutions. Conclusion: This preliminary study with PIXE technique with gold nanoparticle has demonstrated potentials for its utilization in the development of range and dose verification methodology that is currently of great interest in the field of proton radiation therapy.

  8. Establishing an Initial Electron Beam Model with Monte Carlo Simulation for a Single 6 MV X-ray Medical Linac Based on Particle Dynamics Characteristics

    Institute of Scientific and Technical Information of China (English)

    ZHAO Hong-bin; KONG Xiao-xiao; LI Quan-feng; LIN Xiao-qi; BAO Shang-lian

    2009-01-01

    Objective:In this study,we try to establish an initial electron beam model by combining Monte Carlo simulation method with particle dynamic calculation (TRSV) for the single 6 MV X-ray accelerating waveguide of BJ- 6 medical linac. Methods and Materials:1. We adapted the treatment head configuration of BJ- 6 medical linac made by Beijing Medical Equipment Institute (BMEI) as the radiation system for this study. 2. Use particle dynamics calculation code called TRSV to drive out the initial electron beam parameters of the energy spectrum, the spatial intensity distribution, and the beam incidence angle. 3. Analyze the 6 MV X-ray beam characteristics of PDDc, OARc in a water phantom by using Monte Carlo simulation (BEAMnrc,DOSXYZnrc) for a preset of the initial electron beam parameters which have been determined by TRSV, do the comparisons of the measured results of PDDm, OARm in a real water phantom, and then use the deviations of calculated and measured results to slightly modify the initial electron beam model back and forth until the deviations meet the error less than 2%. Results:The deviations between the Monte Carlo simulation results of percentage depth doses at PDDc and off-axis ratios OARc and the measured results of PDDm and OARm in a water phantom were within 2%. Conclusion:When doing the Monte Carlo simulation to determine the parameters of an initial electron beam for a particular medical linac like BJ- 6, modifying some parameters based on the particle dynamics calculation code would give some more reasonable and more acceptable results.

  9. Sci—Thur AM: YIS - 09: Validation of a General Empirically-Based Beam Model for kV X-ray Sources

    Energy Technology Data Exchange (ETDEWEB)

    Poirier, Y. [CancerCare Manitoba (Canada); University of Calgary (Canada); Sommerville, M.; Johnstone, C.D. [San Diego State University (United States); Gräfe, J.; Nygren, I.; Jacso, F. [Tom Baker Cancer Centre (Canada); Khan, R.; Villareal-Barajas, J.E. [University of Calgary (Canada); Tom Baker Cancer Centre (Canada); Tambasco, M. [University of Calgary (Canada); San Diego State University (United States)

    2014-08-15

    Purpose: To present an empirically-based beam model for computing dose deposited by kilovoltage (kV) x-rays and validate it for radiographic, CT, CBCT, superficial, and orthovoltage kV sources. Method and Materials: We modeled a wide variety of imaging (radiographic, CT, CBCT) and therapeutic (superficial, orthovoltage) kV x-ray sources. The model characterizes spatial variations of the fluence and spectrum independently. The spectrum is derived by matching measured values of the half value layer (HVL) and nominal peak potential (kVp) to computationally-derived spectra while the fluence is derived from in-air relative dose measurements. This model relies only on empirical values and requires no knowledge of proprietary source specifications or other theoretical aspects of the kV x-ray source. To validate the model, we compared measured doses to values computed using our previously validated in-house kV dose computation software, kVDoseCalc. The dose was measured in homogeneous and anthropomorphic phantoms using ionization chambers and LiF thermoluminescent detectors (TLDs), respectively. Results: The maximum difference between measured and computed dose measurements was within 2.6%, 3.6%, 2.0%, 4.8%, and 4.0% for the modeled radiographic, CT, CBCT, superficial, and the orthovoltage sources, respectively. In the anthropomorphic phantom, the computed CBCT dose generally agreed with TLD measurements, with an average difference and standard deviation ranging from 2.4 ± 6.0% to 5.7 ± 10.3% depending on the imaging technique. Most (42/62) measured TLD doses were within 10% of computed values. Conclusions: The proposed model can be used to accurately characterize a wide variety of kV x-ray sources using only empirical values.

  10. Stress evaluation in thin films: Micro-focus synchrotron X-ray diffraction combined with focused ion beam patterning for d{sub o} evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Baimpas, Nikolaos, E-mail: nikolaos.baimpas@eng.ox.ac.uk [University of Oxford, Dept. of Engineering Science (United Kingdom); Le Bourhis, Eric [University of Poitiers, Institut P' , Laboratoire de Physique des Matériaux, Poitiers (France); Eve, Sophie [ENSICAEN, CRISMAT, Caen (France); Thiaudière, Dominique [Synchrotron SOLEIL, L' Orme des Merisiers Saint-Aubin, Paris (France); Hardie, Christopher [University of Oxford, Materials Department (United Kingdom); Korsunsky, Alexander M. [University of Oxford, Dept. of Engineering Science (United Kingdom)

    2013-12-31

    Nanocrystalline metallic coatings of sub-micron thickness are widely used in modern microelectronic applications. In X-ray diffraction experiments to determine both the residual and applied stresses in nanocrystalline coatings, one difficult challenge that comes up invariably is the determination of the strain-free lattice spacing d{sub o}. The present study addresses this challenge by using the focused ion beam (FIB) to generate a built-in strain-free reference by patterning (milling) a 50 × 50 μm{sup 2} region of the coating to produce an array of small stress-relieved “islands” ∼ 0.8 × 0.8 μm{sup 2} each. Transmission X-ray diffraction setup was used for data collection at DIFFABS beamline (Synchrotron SOLEIL, France). A 150 nm-thick multi-layered W–Cu nano-composite thin film on polyimide (Kapton®) substrate was studied. The samples were loaded incrementally using a compact uniaxial loading device, and micro-beam diffraction data were collected on and away from the reference array. It was shown experimentally that the “island” array remained approximately strain free throughout the experiment, providing an on-board d{sub o} lattice spacing reference. The changing lattice spacing d in the coating was also monitored away from the array, to deduce the elastic strain evolution during deformation. The results and their implications are presented and discussed. - Highlights: • In situ deformation study of laminate polycrystalline W–Cu thin films • Focused ion beam (FIB) patterning of an array of “islands” on thin films surface • X-ray diffraction on island-patterned region • Constant strain on “islands” independently of the deformation of the substrate.

  11. X-ray flat-panel imager (FPI)-based cone-beam volume CT (CBVCT) under a circle-plus-two-arc data acquisition orbit

    Science.gov (United States)

    Tang, Xiangyang; Ning, Ruola; Yu, Rongfeng; Conover, David L.

    2001-06-01

    The potential of cone beam volume CT (CBVCT) to improve the data acquisition efficiency for volume tomographic imaging is well recognized. A novel x-ray FPI based CBVCT prototype and its preliminary performance evaluation are presented in this paper. To meet the data sufficiency condition, the CBVCT prototype employs a circle-plus-two-arc orbit accomplished by a tiltable circular gantry. A cone beam filtered back-projection (CB-FBP) algorithm is derived for this data acquisition orbit, which employs a window function in the Radon domain to exclude the redundancy between the Radon information obtained from the circular cone beam (CB) data and that from the arc CB data. The number of projection images along the circular sub-orbit and each arc sub-orbit is 512 and 43, respectively. The reconstruction exactness of the prototype x-ray FPI based CBVCT system is evaluated using a disc phantom in which seven acrylic discs are stacked at fixed intervals. Images reconstructed with this algorithm show that both the contrast and geometric distortion existing in the disc phantom images reconstructed by the Feldkamp algorithm are substantially reduced. Meanwhile, the imaging performance of the prototype, such as modulation transfer function (MTF) and low contrast resolution, are quantitatively evaluated in detail through corresponding phantom studies. Furthermore, the capability of the prototype to reconstruct an ROI within a longitudinally unbounded object is verified. The results obtained from this preliminary performance evaluation encourage an expectation of medical applications of the x-ray FPI based CBVCT under the circle-plus-two-arc data acquisition, particularly the application in image-guided interventional procedures and radiotherapy where the movement of a patient table is to be avoided.

  12. Detection of metastases in breast cancer patients. Comparison of FDG PET with chest X-ray, bone scintigraphy and ultrasound of the abdomen

    Energy Technology Data Exchange (ETDEWEB)

    Dose-Schwarz, J.; Mahner, S.; Schirrmacher, S.; Mueller, V. [Klinik und Poliklinik fuer Gynaekologie, Universitaetsklinikum Hamburg-Eppendorf (Germany); Jenicke, L.; Brenner, W. [Klinik fuer Nuklearmedizin, Universitaetsklinikum Hamburg-Eppendorf (Germany); Habermann, C.R. [Klinik fuer Diagnostische und Interventionelle Radiologie, Universitaetsklinikum Hamburg-Eppendorf (Germany)

    2008-07-01

    Distant metastases at primary diagnosis are a prognostic key factor in breast cancer patients and play a central role in therapeutic decisions. To detect them, chest X-ray, abdominal ultrasound, and bone scintigraphy are performed as standard of care in Germany and many centers worldwide. Although FDG PET detects metastatic disease with high accuracy, its diagnostic value in breast cancer still needs to be defined. The aim of this study was to compare the diagnostic performance of FDG PET with conventional imaging. Patients, methods: a retrospective analysis of 119 breast cancer patients who presented for staging was performed. Whole-body FDG-PET (n = 119) was compared with chest X-ray (n = 106) and bone scintigraphy (n = 95). Each imaging modality was independently assessed and classified for metastasis (negative, equivocal and positive). The results of abdominal ultrasound (n = 100) were classified as negative and positive according to written reports. Imaging results were compared with clinical follow-up including follow-up imaging procedures and histopathology. Results: FDG-PET detected distant metastases with a sensitivity of 87.3% and a specificity of 83.3%. In contrast, the sensitivity and specificity of combined conventional imaging procedures was 43.1% and 98.5%, respectively. Regarding so-called equivocal and positive results as positive, the sensitivity and specificity of FDG-PET was 93.1% and 76.6%, respectively, compared to 61.2% and 86.6% for conventional imaging. Regarding different locations of metastases the sensitivity of FDG PET was superior in the detection of pulmonary metastases and lymph node metastases of the mediastinum in comparison to chest X-ray, whereas the sensitivity of FDG PET in the detection of bone and liver metastases was comparable with bone scintigraphy and ultrasound of the abdomen. Conclusions: FDG-PET is more sensitive than conventional imaging procedures for detection of distant breast cancer metastases and should be

  13. X-ray microfluorescence as a tool to analyze elemental changes in femur head induced by chemotherapy drugs for the treatment of breast cancer

    Science.gov (United States)

    Pickler, A.; Mota, C. L.; Mantuano, A.; Salata, C.; Nogueira, L. P.; Almeida, A. P.; Alessio, R.; Sena, G.; Braz, D.; de Almeida, C. E. V.; Barroso, R. C.

    2015-11-01

    Recently some developments in a large number of investigative techniques have been made with the objective to obtain a micrometer spatial resolution imaging of elemental concentrations. The X-ray microfluorescence analysis (μXRF) is one of those techniques which is based on the localized excitation of a small area on the surface of sample, providing information of all elements contained in the material under study. Breast cancer is the most common malignancy in Brazilian women. The main treatment strategies for the breast cancer are surgery and chemotherapy. As bone loss is one of the possible chemotherapy side effects, in this work was used μXRF technique on femoral head samples of female Wistar rats to evaluate Ca, Fe and Zn concentrations in order to investigate possible elemental changes in bone caused by the chemotherapy. Fifteen female rats were divided randomly in groups (five rats each). G1 group received doses of doxorubicin/cyclophosphamide drugs and G2 group was treated with docetaxel/cyclophosphamide drugs. μXRF measurements were carried out at the X-ray XRF beamline in the Brazilian Synchrotron Light Laboratory. The results showed significant decrease especially in Ca concentrations when comparing the treated groups with the control group.

  14. Measuring one-dimensional and two-dimensional impurity density profiles on TEXTOR using combined charge exchange-beam emission spectroscopy and ultrasoft x-ray tomography

    Science.gov (United States)

    De Bock, M.; Jakubowska, K.; Hellermann, M. von; Jaspers, R.; Donné, A. J. H.; Shmaenok, L.

    2004-10-01

    Two techniques are presented that allow us to measure impurity density profiles in the TEXTOR tokamak plasma. The one-dimensional profiles are gathered by charge exchange recombination spectroscopy (CXRS) in combination with beam emission spectroscopy (BES). Combining CXRS and BES eliminate the need for absolute calibration. For two-dimensional profiles an ultrasoft x-ray tomography system has been developed. The system is spectrally resolved and produces local emissivity profiles of several ionization stages of impurities. Both systems are presently being commissioned. They are complementary and give an insight into the impurity distribution and transport in plasmas.

  15. Precision scans of the Pixel cell response of double sided 3D Pixel detectors to pion and X-ray beams

    CERN Document Server

    Mac Raighne, A; Crossley, M; Alianelli, L; Lozano, M; Dumps, R; Fleta, C; Collins, P; Rodrigues, E; Sawhney, K J S; Tlustos, L; Pennicard, D; Buytaert, J; Stewart, G; Parkes, C; Eklund, L; Campbell, M; Marchal, J; Akiba, K; Pellegrini, G; Llopart, X; Plackett, R; Maneuski, D; Gligorov, V V; Tartoni, N; Nicol, M; Bates, R; Gallas, A; Gimenez, E N; van Beuzekom, M; John, M

    2011-01-01

    Three-dimensional (3D) silicon sensors offer potential advantages over standard planar sensors for radiation hardness in future high energy physics experiments and reduced charge-sharing for X-ray applications, but may introduce inefficiencies due to the columnar electrodes. These inefficiencies are probed by studying variations in response across a unit pixel cell in a 55 m m pitch double-sided 3D pixel sensor bump bonded to TimePix and Medipix2 readout ASICs. Two complementary characterisation techniques are discussed: the first uses a custom built telescope and a 120GeV pion beam from the Super Proton Synchrotron (SPS) at CERN; the second employs a novel technique to illuminate the sensor with a micro-focused synchrotron X-ray beam at the Diamond Light Source, UK. For a pion beam incident perpendicular to the sensor plane an overall pixel efficiency of 93.0 +/- 0.5\\% is measured. After a 10 degrees rotation of the device the effect of the columnar region becomes negligible and the overall efficiency rises ...

  16. Experimental demonstration of benchtop x-ray fluorescence computed tomography (XFCT) of gold nanoparticle-loaded objects using lead- and tin-filtered polychromatic cone-beams.

    Science.gov (United States)

    Jones, Bernard L; Manohar, Nivedh; Reynoso, Francisco; Karellas, Andrew; Cho, Sang Hyun

    2012-12-07

    This report presents the first experimental demonstration, to our knowledge, of benchtop polychromatic cone-beam x-ray fluorescence computed tomography (XFCT) for a simultaneous determination of the spatial distribution and amount of gold nanoparticles (GNPs) within small-animal-sized objects. The current benchtop experimental setup successfully produced XFCT images accurately showing the regions containing small amount of GNPs (on the order of 0.1 mg) within a 3 cm diameter plastic phantom. In particular, the performance of the current XFCT setup was improved remarkably (e.g., at least a factor of 3 reduction in XFCT scan time) using a tin-filtered polychromatic beam in comparison with a lead-filtered beam. The results of this study strongly suggest that the current benchtop XFCT configuration can be made practical with a few modifications such as the deployment of array detectors, while meeting realistic constraints on x-ray dose, scan time and image resolution for routine pre-clinical in vivo imaging with GNPs.

  17. A comparative study of high resolution cone beam X-ray tomography and synchrotron tomography applied to Fe- and Al-alloys.

    Science.gov (United States)

    Kastner, Johann; Harrer, Bernhard; Requena, Guillermo; Brunke, Oliver

    2010-10-01

    X-ray computed tomography (XCT) has become a very important method for non-destructive 3D-characterization and evaluation of materials. Due to measurement speed and quality, XCT systems with cone beam geometry and matrix detectors have gained general acceptance. Continuous improvements in the quality and performance of X-ray tubes and XCT devices have led to cone beam CT systems that can now achieve spatial resolutions down to 1 μm and even below. However, the polychromatic nature of the source, limited photon flux and cone beam artefacts mean that there are limits to the quality of the CT-data achievable; these limits are particularly pronounced with materials of higher density like metals. Synchrotron radiation offers significant advantages by its monochromatic and parallel beam of high brilliance. These advantages usually cause fewer artefacts, improved contrast and resolution.Tomography data of a steel sample and of two multi-phase Al-samples (AlSi12Ni1, AlMg5Si7) are recorded by advanced cone beam XCT-systems with a μ-focus (μXCT) and a sub-μm (nano-focus, sub-μXCT) X-ray source with voxel dimensions between 0.4 and 3.5 μm and are compared with synchrotron computed tomography (sXCT) with 0.3 μm/voxel. CT data features like beam hardening and ring artefacts, detection of details, sharpness, contrast, signal-to-noise ratio and the grey value histogram are systematically compared. In all cases μXCT displayed the lowest performance. Sub-μXCT gives excellent results in the detection of details, spatial and contrast resolution, which are comparable to synchrotron-XCT recordings. The signal-to-noise ratio is usually significantly lower for sub-μXCT compared with the two other methods. With regard to measurement costs "for industrial users", scanning volume, accessibility and user-friendliness sub-μXCT has significant advantages in comparison to synchrotron-XCT.

  18. Abdominal x-ray

    Science.gov (United States)

    ... are, or may be, pregnant. Alternative Names Abdominal film; X-ray - abdomen; Flat plate; KUB x-ray ... Assistant Studies, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington, Seattle, WA. Also ...

  19. Extremity x-ray

    Science.gov (United States)

    ... degenerative) Bone tumor Broken bone (fracture) Dislocated bone Osteomyelitis (infection) Arthritis Other conditions for which the test ... Bone tumor Bone x-ray Broken bone Clubfoot Osteomyelitis X-ray Review Date 7/3/2016 Updated ...

  20. Enhancement of breast calcification visualization and detection using a modified PG method in Cone Beam Breast CT.

    Science.gov (United States)

    Liu, Jiangkun; Ning, Ruola; Cai, Weixing; Benitez, Ricardo Betancourt

    2012-01-01

    Cone Beam Breast CT is a promising diagnostic modality in breast imaging. Its isotropic 3D spatial resolution enhances the characterization of micro-calcifications in breasts that might not be easily distinguishable in mammography. However, due to dose level considerations, it is beneficial to further enhance the visualization of calcifications in Cone Beam Breast CT images that might be masked by noise. In this work, the Papoulis-Gerchberg method was modified and implemented in Cone Beam Breast CT images to improve the visualization and detectability of calcifications. First, the PG method was modified and applied to the projections acquired during the scanning process; its effects on the reconstructed images were analyzed by measuring the Modulation Transfer Function and the Noise Power Spectrum. Second, Cone Beam Breast CT images acquired at different dose levels were pre-processed using this technique to enhance the visualization of calcification. Finally, a computer-aided diagnostic algorithm was utilized to evaluate the efficacy of this method to improve calcification detectability. The results demonstrated that this technique can effectively improve image quality by improving the Modulation Transfer Function with a minor increase in noise level. Consequently, the visualization and detectability of calcifications were improved in Cone Beam Breast CT images. This technique was also proved to be useful in reducing the x-ray dose without degrading visualization and detectability of calcifications.

  1. Comparison of fan- and cone-beam imaging capabilities on a portable x-ray imaging system

    Science.gov (United States)

    White, Timothy A.; Roney, Tim J.; Pink, Robert J.; Noo, Frederic; Clackdoyle, Rolf; Smith, Mike; Jones, Warren F.

    1999-09-01

    Portable systems for x-ray imaging of objects up to 20-cm in diameter have been developed for field inspection of industrial objects. These systems can be configured with either a linear diode array (45-cm long, 1024-elements, 12- bits/element) or a large-area amorphous-silicon (a-Si) detector (30 X 40-cm2, 2304 X 3200-elements, 12- bits/element). Each detector utilizes gadolinium oxysulfide as the scintillation element. X-rays are emitted from an 80 to 300-kVp constant-potential source with a spot size of approximately 1.6-mm. The object can be rotated and the source and detector translated vertically for collection of 'spiral' fanbeam or 'helical' conebeam computed-tomography (CT) data. For low-density objects, the reconstructed spatial resolution of CT data collected with either detector is about the same and the choice of detector is determined by detector parameters such as dynamic range and integration/readout time. For higher-density objects, which need to be imaged at higher energies and for which there is a higher probability of Compton scatter, the linear diode array produces better contrast images of small voids in a scattering medium. A series of experiments designed to test the performance of each detector with and without a scattering medium will be presented.

  2. The Clinical Value of Molybdenum X-ray in Breast Cancer Diagnosis%钼钯X线在乳腺癌中的临床应用价值

    Institute of Scientific and Technical Information of China (English)

    吴焱

    2014-01-01

    目的:探讨钼钯x线对乳腺癌的诊断价值。方法:收集我院2010年1月至2013年2月间病例资料完整28例乳腺癌病例,所有病例均经手术病理证实,回顾性分析其x线表现,包括直接征象、间接征象。结果:28例乳腺癌中,左乳15例,右乳13例,部位以外上象限最多见,有17例;浸润性导管癌25例,混合癌1例,富于糖原透明细胞癌1例,原位癌1例;x线表现:肿块23例,微小钙化14例,局限性密度增高4例,结构紊乱2例,钙化伴星芒征2例,腺体结构紊乱伴异常血管影2例,乳头回缩、漏斗征2例,局部皮肤凹陷2例;局限性皮肤增厚2例;血管增粗1例,乳腺内淋巴结或腋前淋巴结肿大5例,结论:钼钯x线在乳腺癌的临床诊断与鉴别诊断中具有重要的价值,是诊断乳腺癌的首选影像学方法。%This paper aims at investigating the value of molybdenum X-ray in the diagnosis of breast cancer. The author col ected 28 breast cancer cases from January 2010 to February 2013, al of which have been confirmed both by surgery and pathology, and conducted retrospective analysis of the X-ray expression of these cases, including the direct and indirect signs. The result shows that, among the 28 breast cancer cases, there are 15 cases of breast cancer and 13 cases of right breast cancer. The parts of most of the patients are in upper quadrant and the parts of 17 cases are there; 25 cases of infiltrative ductal carcinoma,1case of mixed type carcinoma, 1 case of glycogen-rich, clear cellcarcinoma,1 case of carcinoma in situ; The X-ray findings include: mass(n=23),micro calcification(n=14), and limited density increase(n=4),2 cases of structural disorder, 2 cases of calcification with asterism,2 cases of gland disorder with abnormal blood vessel film, inverted nipple and hopper symptom (n=2), 2 cases of local skin pitting; limited pachyderma symptom(n=2), vascular increase(n=1), 5 cases of mammary

  3. Dose-response curve of EBT, EBT2, and EBT3 radiochromic films to synchrotron-produced monochromatic x-ray beams

    CERN Document Server

    Brown, Thomas A D; Alvarez, Diane; Matthews, Kenneth L; Ham, Kyungmin; Dugas, Joseph P; 10.1118/1.4767770

    2012-01-01

    This work investigates the dose-response curves of GAFCHROMIC EBT, EBT2, and EBT3 radiochromic films using synchrotron-produced monochromatic x-ray beams. EBT2 film is being utilized for dose verification in photoactivated Auger electron therapy at the Louisiana State University CAMD synchrotron facility. Monochromatic beams of 25, 30, and 35 keV were generated on the tomography beamline at CAMD. Ion chamber depth-dose measurements were used to determine the dose delivered to films irradiated at depths from 0.7 to 8.5 cm in a 10x10x10-cm3 PMMA phantom. AAPM TG-61 protocol was applied to convert measured ionization into dose. Films were digitized using an Epson 1680 Professional flatbed scanner and analyzed using the net optical density (NOD) derived from the red channel. A dose-response curve was obtained at 35 keV for EBT film, and at 25, 30, and 35 keV for EBT2 and EBT3 films. Calibrations of films for 4 MV x-rays were obtained for comparison using a radiotherapy accelerator at Mary Bird Perkins Cancer Cent...

  4. Lepton contamination and photon scatter produced by open field 18 MV X-ray beams in the build-up region

    Energy Technology Data Exchange (ETDEWEB)

    Butson, M.J. E-mail: mbutson@guessmail.com; Cheung Tsang; Yu, P.K.N

    2002-04-01

    18 MV X-ray beams used in radiotherapy have skin sparing properties as they produce a dose build-up effect whereby a smaller dose is delivered to the skin compared to dose at depth. Experimental results have shown that variations in the build-up dose significantly contribute to lepton contamination produced outside of the patient or the phantom in question. Monte Carlo simulations of 18 MV X-ray beams show that the surface dose contribution from in-phantom scatter alone is approximately 6% of the maximum dose. The contribution to dose from lepton contamination is found by comparison of Monte Carlo phantom photon scatter dose only and experimental data. Results show that the percentage contributions to dose from lepton contamination are approximately, 65%, 90% of dose at 0.05 mm (basal cell layer), 52%, 79% at 1 mm depth (dermal layer) and 15%, 26% at 10 mm depth (subcutaneous tissue) for 10 cmx10 cm{sup 2} and 40 cmx40 cm{sup 2} fields, respectively.

  5. Potential applications of a dual-sweep streak camera system for characterizing particle and photon beams of VUV, XUV, and x-ray FELS

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, A. [Argonne National Lab., IL (United States)

    1995-12-31

    The success of time-resolved imaging techniques in the Characterization of particle beams and photon beams of the recent generation of L-band linac-driven or storage ring FELs in the infrared, visible, and ultraviolet wavelength regions can be extended to the VUV, XUV, and x-ray FELs. Tests and initial data have been obtained with the Hamamatsu C5680 dual-sweep streak camera system which includes a demountable photocathode (thin Au) assembly and a flange that allows windowless operation with the transport vacuum system. This system can be employed at wavelengths shorter than 100 nm and down to 1 {Angstrom}. First tests on such a system at 248-nm wavelengths have been performed oil the Argonne Wakefield Accelerator (AWA) drive laser source. A quartz window was used at the tube entrance aperture. A preliminary test using a Be window mounted on a different front flange of the streak tube to look at an x-ray bremsstrahlung source at the AWA was limited by photon statistics. This system`s limiting resolution of {sigma}{approximately}1.1 ps observed at 248 nm would increase with higher incoming photon energies to the photocathode. This effect is related to the fundamental spread in energies of the photoelectrons released from the photocathodes. Possible uses of the synchrotron radiation sources at the Advanced Photon Source and emerging short wavelength FELs to test the system will be presented.

  6. Amorphous In–Ga–Zn–O thin-film transistor active pixel sensor x-ray imager for digital breast tomosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Chumin; Kanicki, Jerzy, E-mail: kanicki@eecs.umich.edu [Solid-State Electronic Laboratory, Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan 48109 (United States)

    2014-09-15

    Purpose: The breast cancer detection rate for digital breast tomosynthesis (DBT) is limited by the x-ray image quality. The limiting Nyquist frequency for current DBT systems is around 5 lp/mm, while the fine image details contained in the high spatial frequency region (>5 lp/mm) are lost. Also today the tomosynthesis patient dose is high (0.67–3.52 mGy). To address current issues, in this paper, for the first time, a high-resolution low-dose organic photodetector/amorphous In–Ga–Zn–O thin-film transistor (a-IGZO TFT) active pixel sensor (APS) x-ray imager is proposed for next generation DBT systems. Methods: The indirect x-ray detector is based on a combination of a novel low-cost organic photodiode (OPD) and a cesium iodide-based (CsI:Tl) scintillator. The proposed APS x-ray imager overcomes the difficulty of weak signal detection, when small pixel size and low exposure conditions are used, by an on-pixel signal amplification with a significant charge gain. The electrical performance of a-IGZO TFT APS pixel circuit is investigated by SPICE simulation using modified Rensselaer Polytechnic Institute amorphous silicon (a-Si:H) TFT model. Finally, the noise, detective quantum efficiency (DQE), and resolvability of the complete system are modeled using the cascaded system formalism. Results: The result demonstrates that a large charge gain of 31–122 is achieved for the proposed high-mobility (5–20 cm{sup 2}/V s) amorphous metal-oxide TFT APS. The charge gain is sufficient to eliminate the TFT thermal noise, flicker noise as well as the external readout circuit noise. Moreover, the low TFT (<10{sup −13} A) and OPD (<10{sup −8} A/cm{sup 2}) leakage currents can further reduce the APS noise. Cascaded system analysis shows that the proposed APS imager with a 75 μm pixel pitch can effectively resolve the Nyquist frequency of 6.67 lp/mm, which can be further improved to ∼10 lp/mm if the pixel pitch is reduced to 50 μm. Moreover, the

  7. Instrument and method for X-ray diffraction, fluorescence, and crystal texture analysis without sample preparation

    Science.gov (United States)

    Gendreau, Keith (Inventor); Martins, Jose Vanderlei (Inventor); Arzoumanian, Zaven (Inventor)

    2010-01-01

    An X-ray diffraction and X-ray fluorescence instrument for analyzing samples having no sample preparation includes a X-ray source configured to output a collimated X-ray beam comprising a continuum spectrum of X-rays to a predetermined coordinate and a photon-counting X-ray imaging spectrometer disposed to receive X-rays output from an unprepared sample disposed at the predetermined coordinate upon exposure of the unprepared sample to the collimated X-ray beam. The X-ray source and the photon-counting X-ray imaging spectrometer are arranged in a reflection geometry relative to the predetermined coordinate.

  8. Mapping the structural order of laser-induced periodic surface structures in thin polymer films by microfocus beam grazing incidence small-angle X-ray scattering.

    Science.gov (United States)

    Martín-Fabiani, Ignacio; Rebollar, Esther; García-Gutiérrez, Mari Cruz; Rueda, Daniel R; Castillejo, Marta; Ezquerra, Tiberio A

    2015-02-11

    In this work we present an accurate mapping of the structural order of laser-induced periodic surface structures (LIPSS) in spin-coated thin polymer films, via a microfocus beam grazing incidence small-angle X-ray scattering (μGISAXS) scan, GISAXS modeling, and atomic force microscopy imaging all along the scanned area. This combined study has allowed the evaluation of the effects on LIPSS formation due to nonhomogeneous spatial distribution of the laser pulse energy, mapping with micrometric resolution the evolution of the period and degree of structural order of LIPSS across the laser beam diameter in a direction perpendicular to the polarization vector. The experiments presented go one step further toward controlling nanostructure formation in LIPSS through a deep understanding of the parameters that influence this process.

  9. Analysis of the variation of the attenuation curve in function of the radiation field size for k Vp X-ray beams using the MCNP-5C code

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, Marco A.R., E-mail: marco@cetea.com.b, E-mail: marfernandes@fmb.unesp.b [Universidade Estadual Paulista Julio de Mesquita Filho (FMB/UNESP), Botucatu, SP (Brazil). Fac. de Medicina; Ribeiro, Victor A.B. [Universidade Estadual Paulista Julio de Mesquita Filho (IBB/UNESP), Botucatu, SP (Brazil). Inst. de Biociencias; Viana, Rodrigo S.S.; Coelho, Talita S. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    The paper illustrates the use of the Monte Carlo method, MCNP-5C code, to analyze the attenuation curve behavior of the 50 kVp radiation beam from superficial radiotherapy equipment as Dermopan2 model. The simulations seek to verify the MCNP-5C code performance to study the variation of the attenuation curve - percentage depth dose (PDD) curve - in function of the radiation field dimension used at radiotherapy of skin tumors with 50 kVp X-ray beams. The PDD curve was calculated for six different radiation field sizes with circular geometry of 1.0, 2.0, 3.0, 4.0, 5.0 and 6.0 cm in diameter. The radiation source was modeled considering a tungsten target with inclination 30 deg, focal point of 6.5 mm in diameter and energy beam of 50 kVp; the X-ray spectrum was calculated with the MCNP-5C code adopting total filtration (beryllium window of 1 mm and aluminum additional filter of 1 mm). The PDD showed decreasing behavior with the attenuation depth similar what is presented on the literature. There was not significant variation at the PDD values for the radiation field between 1.0 and 4.0 cm in diameter. The differences increased for fields of 5.0 and 6.0 cm and at attenuation depth higher than 1.0 cm. When it is compared the PDD values for fields of 3.0 and 6.0 cm in diameter, it verifies the greater difference (12.6 %) at depth of 5.7 cm, proving the scattered radiation effect. The MCNP-5C code showed as an appropriate procedure to analyze the attenuation curves of the superficial radiotherapy beams. (author)

  10. The feasibility of polychromatic cone-beam x-ray fluorescence computed tomography (XFCT) imaging of gold nanoparticle-loaded objects: a Monte Carlo study

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Bernard L; Cho, Sang Hyun, E-mail: scho@gatech.edu [Nuclear/Radiological Engineering and Medical Physics Programs, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0405 (United States)

    2011-06-21

    A recent study investigated the feasibility to develop a bench-top x-ray fluorescence computed tomography (XFCT) system capable of determining the spatial distribution and concentration of gold nanoparticles (GNPs) in vivo using a diagnostic energy range polychromatic (i.e. 110 kVp) pencil-beam source. In this follow-up study, we examined the feasibility of a polychromatic cone-beam implementation of XFCT by Monte Carlo (MC) simulations using the MCNP5 code. In the current MC model, cylindrical columns with various sizes (5-10 mm in diameter) containing water loaded with GNPs (0.1-2% gold by weight) were inserted into a 5 cm diameter cylindrical polymethyl methacrylate phantom. The phantom was then irradiated by a lead-filtered 110 kVp x-ray source, and the resulting gold fluorescence and Compton-scattered photons were collected by a series of energy-sensitive tallies after passing through lead parallel-hole collimators. A maximum-likelihood iterative reconstruction algorithm was implemented to reconstruct the image of GNP-loaded objects within the phantom. The effects of attenuation of both the primary beam through the phantom and the gold fluorescence photons en route to the detector were corrected during the image reconstruction. Accurate images of the GNP-containing phantom were successfully reconstructed for three different phantom configurations, with both spatial distribution and relative concentration of GNPs well identified. The pixel intensity of regions containing GNPs was linearly proportional to the gold concentration. The current MC study strongly suggests the possibility of developing a bench-top, polychromatic, cone-beam XFCT system for in vivo imaging.

  11. The feasibility of polychromatic cone-beam x-ray fluorescence computed tomography (XFCT) imaging of gold nanoparticle-loaded objects: a Monte Carlo study

    Science.gov (United States)

    Jones, Bernard L.; Cho, Sang Hyun

    2011-06-01

    A recent study investigated the feasibility to develop a bench-top x-ray fluorescence computed tomography (XFCT) system capable of determining the spatial distribution and concentration of gold nanoparticles (GNPs) in vivo using a diagnostic energy range polychromatic (i.e. 110 kVp) pencil-beam source. In this follow-up study, we examined the feasibility of a polychromatic cone-beam implementation of XFCT by Monte Carlo (MC) simulations using the MCNP5 code. In the current MC model, cylindrical columns with various sizes (5-10 mm in diameter) containing water loaded with GNPs (0.1-2% gold by weight) were inserted into a 5 cm diameter cylindrical polymethyl methacrylate phantom. The phantom was then irradiated by a lead-filtered 110 kVp x-ray source, and the resulting gold fluorescence and Compton-scattered photons were collected by a series of energy-sensitive tallies after passing through lead parallel-hole collimators. A maximum-likelihood iterative reconstruction algorithm was implemented to reconstruct the image of GNP-loaded objects within the phantom. The effects of attenuation of both the primary beam through the phantom and the gold fluorescence photons en route to the detector were corrected during the image reconstruction. Accurate images of the GNP-containing phantom were successfully reconstructed for three different phantom configurations, with both spatial distribution and relative concentration of GNPs well identified. The pixel intensity of regions containing GNPs was linearly proportional to the gold concentration. The current MC study strongly suggests the possibility of developing a bench-top, polychromatic, cone-beam XFCT system for in vivo imaging.

  12. Experimental validation of a Monte Carlo-based kV x-ray projection model for the Varian linac-mounted cone-beam CT imaging system

    Science.gov (United States)

    Lazos, Dimitrios; Pokhrel, Damodar; Su, Zhong; Lu, Jun; Williamson, Jeffrey F.

    2008-03-01

    Fast and accurate modeling of cone-beam CT (CBCT) x-ray projection data can improve CBCT image quality either by linearizing projection data for each patient prior to image reconstruction (thereby mitigating detector blur/lag, spectral hardening, and scatter artifacts) or indirectly by supporting rigorous comparative simulation studies of competing image reconstruction and processing algorithms. In this study, we compare Monte Carlo-computed x-ray projections with projections experimentally acquired from our Varian Trilogy CBCT imaging system for phantoms of known design. Our recently developed Monte Carlo photon-transport code, PTRAN, was used to compute primary and scatter projections for cylindrical phantom of known diameter (NA model 76-410) with and without bow-tie filter and antiscatter grid for both full- and half-fan geometries. These simulations were based upon measured 120 kVp spectra, beam profiles, and flat-panel detector (4030CB) point-spread function. Compound Poisson- process noise was simulated based upon measured beam output. Computed projections were compared to flat- and dark-field corrected 4030CB images where scatter profiles were estimated by subtracting narrow axial-from full axial width 4030CB profiles. In agreement with the literature, the difference between simulated and measured projection data is of the order of 6-8%. The measurement of the scatter profiles is affected by the long tails of the detector PSF. Higher accuracy can be achieved mainly by improving the beam modeling and correcting the non linearities induced by the detector PSF.

  13. X-Ray Supernovae

    CERN Document Server

    Immler, S; Immler, Stefan; Lewin, Walter H.G.

    2002-01-01

    We present a review of X-ray observations of supernovae (SNe). By observing the (~0.1--100 keV) X-ray emission from young SNe, physical key parameters such as the circumstellar matter (CSM) density, mass-loss rate of the progenitor and temperature of the outgoing and reverse shock can be derived as a function of time. Despite intensive search over the last ~25 years, only 15 SNe have been detected in X-rays. We review the individual X-ray observations of these SNe and discuss their implications as to our understanding of the physical processes giving rise to the X-ray emission.

  14. A graphite calorimeter for absolute measurements of absorbed dose to water: application in medium-energy x-ray filtered beams

    Science.gov (United States)

    Pinto, M.; Pimpinella, M.; Quini, M.; D'Arienzo, M.; Astefanoaei, I.; Loreti, S.; Guerra, A. S.

    2016-02-01

    The Italian National Institute of Ionizing Radiation Metrology (ENEA-INMRI) has designed and built a graphite calorimeter that, in a water phantom, has allowed the determination of the absorbed dose to water in medium-energy x-rays with generating voltages from 180 to 250 kV. The new standard is a miniaturized three-bodies calorimeter, with a disc-shaped core of 21 mm diameter and 2 mm thickness weighing 1.134 g, sealed in a PMMA waterproof envelope with air-evacuated gaps. The measured absorbed dose to graphite is converted into absorbed dose to water by means of an energy-dependent conversion factor obtained from Monte Carlo simulations. Heat-transfer correction factors were determined by FEM calculations. At a source-to-detector distance of 100 cm, a depth in water of 2 g cm-2, and at a dose rate of about 0.15 Gy min-1, results of calorimetric measurements of absorbed dose to water, D w, were compared to experimental determinations, D wK, obtained via an ionization chamber calibrated in terms of air kerma, according to established dosimetry protocols. The combined standard uncertainty of D w and D wK were estimated as 1.9% and 1.7%, respectively. The two absorbed dose to water determinations were in agreement within 1%, well below the stated measurement uncertainties. Advancements are in progress to extend the measurement capability of the new in-water-phantom graphite calorimeter to other filtered medium-energy x-ray qualities and to reduce the D w uncertainty to around 1%. The new calorimeter represents the first implementation of in-water-phantom graphite calorimetry in the kilovoltage range and, allowing independent determinations of D w, it will contribute to establish a robust system of absorbed dose to water primary standards for medium-energy x-ray beams.

  15. A Study on Stereoscopic X-ray Imaging Data Set on the Accuracy of Real-Time Tumor Tracking in External Beam Radiotherapy.

    Science.gov (United States)

    Esmaili Torshabi, Ahmad; Ghorbanzadeh, Leila

    2017-04-01

    At external beam radiotherapy, stereoscopic X-ray imaging system is responsible as tumor motion information provider. This system takes X-ray images intermittently from tumor position (1) at pretreatment step to provide training data set for model construction and (2) during treatment to control the accuracy of correlation model performance. In this work, we investigated the effect of imaging data points provided by this system on treatment quality. Because some information is still lacking about (1) the number of imaging data points, (2) shooting time for capturing each data point, and also (3) additional imaging dose delivered by this system. These 3 issues were comprehensively assessed at (1) pretreatment step while training data set is gathered for prediction model construction and (2) during treatment while model is tested and reconstructed using new arrival data points. A group of real patients treated with CyberKnife Synchrony module was chosen in this work, and an adaptive neuro-fuzzy inference system was considered as consistent correlation model. Results show that a proper model can be constructed while the number of imaging data points is highly enough to represent a good pattern of breathing cycles. Moreover, a trade-off between the number of imaging data points and additional imaging dose is considered in this study. Since breathing phenomena are highly variable at different patients, the time for taking some of imaging data points is very important, while their absence at that critical time may yield wrong tumor tracking. In contrast, the sensitivity of another category of imaging data points is not high, while breathing is normal and in the control range. Therefore, an adaptive supervision on the implementation of stereoscopic X-ray imaging is proposed to intelligently accomplish shooting process, based on breathing motion variations.

  16. X-ray Echo Spectroscopy.

    Science.gov (United States)

    Shvyd'ko, Yuri

    2016-02-26

    X-ray echo spectroscopy, a counterpart of neutron spin echo, is being introduced here to overcome limitations in spectral resolution and weak signals of the traditional inelastic x-ray scattering (IXS) probes. An image of a pointlike x-ray source is defocused by a dispersing system comprised of asymmetrically cut specially arranged Bragg diffracting crystals. The defocused image is refocused into a point (echo) in a time-reversal dispersing system. If the defocused beam is inelastically scattered from a sample, the echo signal acquires a spatial distribution, which is a map of the inelastic scattering spectrum. The spectral resolution of the echo spectroscopy does not rely on the monochromaticity of the x rays, ensuring strong signals along with a very high spectral resolution. Particular schemes of x-ray echo spectrometers for 0.1-0.02 meV ultrahigh-resolution IXS applications (resolving power >10^{8}) with broadband ≃5-13  meV dispersing systems are introduced featuring more than 10^{3} signal enhancement. The technique is general, applicable in different photon frequency domains.

  17. X-ray Echo Spectroscopy

    Science.gov (United States)

    Shvyd'ko, Yuri

    2016-02-01

    X-ray echo spectroscopy, a counterpart of neutron spin echo, is being introduced here to overcome limitations in spectral resolution and weak signals of the traditional inelastic x-ray scattering (IXS) probes. An image of a pointlike x-ray source is defocused by a dispersing system comprised of asymmetrically cut specially arranged Bragg diffracting crystals. The defocused image is refocused into a point (echo) in a time-reversal dispersing system. If the defocused beam is inelastically scattered from a sample, the echo signal acquires a spatial distribution, which is a map of the inelastic scattering spectrum. The spectral resolution of the echo spectroscopy does not rely on the monochromaticity of the x rays, ensuring strong signals along with a very high spectral resolution. Particular schemes of x-ray echo spectrometers for 0.1-0.02 meV ultrahigh-resolution IXS applications (resolving power >108 ) with broadband ≃5 - 13 meV dispersing systems are introduced featuring more than 103 signal enhancement. The technique is general, applicable in different photon frequency domains.

  18. X-ray echo spectroscopy

    CERN Document Server

    Shvyd'ko, Yuri

    2015-01-01

    X-ray echo spectroscopy, a counterpart of neutron spin-echo, is being introduced here to overcome limitations in spectral resolution and weak signals of the traditional inelastic x-ray scattering (IXS) probes. An image of a point-like x-ray source is defocused by a dispersing system comprised of asymmetrically cut specially arranged Bragg diffracting crystals. The defocused image is refocused into a point (echo) in a time-reversal dispersing system. If the defocused beam is inelastically scattered from a sample, the echo signal acquires a spatial distribution, which is a map of the inelastic scattering spectrum. The spectral resolution of the echo spectroscopy does not rely on the monochromaticity of the x-rays, ensuring strong signals along with a very high spectral resolution. Particular schemes of x-ray echo spectrometers for 0.1--0.02-meV ultra-high-resolution IXS applications (resolving power $> 10^8$) with broadband $\\simeq$~5--13~meV dispersing systems are introduced featuring more than $10^3$ signal e...

  19. TU-EF-207-05: Dedicated Cone-beam Breast CT

    Energy Technology Data Exchange (ETDEWEB)

    Vedantham, S. [Univ. of Massachusetts Medical School (United States)

    2015-06-15

    mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation.

  20. Study on trace elements behaviour in cancerous and healthy tissues of colon, breast and stomach: Total reflection X-ray fluorescence applications

    Science.gov (United States)

    Magalhães, T.; Carvalho, M. L.; Von Bohlen, A.; Becker, M.

    2010-06-01

    In this work Total-reflection X-ray fluorescence (TXRF) was used to analyse healthy and cancerous tissues of the same individual along several contiguous thin sections of each tissue. Thirty two samples (16 pairs) of breast tissue, 30 samples (15 pairs) of intestine tissue and 10 samples (5 pairs) of stomach tissue were analysed. The samples were obtained in Civil Hospitals of Germany (Dortmund) and Portugal (Lisbon). The elemental distribution of P, S, Cl, K, Ca, Cr, Mn, Fe, Ni, Cu, Zn, Se, Br, Rb, Sr and Pb in these samples was studied. Descriptive statistics based on bar graphics and hypotheses tests and also an automatic classification based on hierarchical grouping analysis was used for the several analysed tissues. It was shown that the behaviour of the elements is tissue dependent. Some elements, like P and K exhibit the same behaviour in all the analysed tissue types. They have increased concentrations in all cancerous tissues. Unlike, other elements like Br show completely different behaviour depending on the tissue: similar concentration in healthy and cancerous stomach, decreased levels in colon cancerous tissues and enhanced concentrations in breast was observed. Moreover cancer tissues present decreased Se concentrations on colon and increased on breast.

  1. Investigation of the Distribution of Elements in Snail Shell With the use of Synchrotron-Based, Micro-Beam X-ray Fluorescence Spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Rao, D.; Swapna, M; Cesareo, R; Brunetti, A; Akatsuka, T; Yuasa, T; Takeda, T; Tromba, G; Gigante, G

    2009-01-01

    In this study, synchrotron-based micro-beam was utilized for elemental mapping of a small animal shell. A thin X-ray spot of the order of {approx}10 em was focused on the sample. With this spatial resolution and high flux throughput, the X-ray fluorescent intensities for Ca, Mn, Fe, Ni, Zn, Cr and Cu were measured using a liquid-nitrogen-cooled 13-element energy-dispersive HpGe detector. The sample is scanned in a estep-and-repeat' mode for fast elemental mapping and generated elemental maps at 8, 10 and 12 keV. All images are of 10 em resolution and the measurement time was 1 s per point. The accumulation of trace elements was investigated from the soft-tissue in small areas. Analysis of the small areas will be better suited to establish the physiology of metals in specific structures like small animal shell and the distribution of other trace elements.

  2. Impulsive solar X-ray bursts. 4: Polarization, directivity and spectrum of the reflected and total bremsstrahlung radiation from a beam of electrons directed toward the photosphere

    Science.gov (United States)

    Langer, S. H.; Petrosian, V.

    1976-01-01

    A Monte Carlo method is described for evaluation of the spectrum, directivity and polarization of X-rays diffusely reflected from stellar photospheres. the accuracy of the technique is evaluated through comparison with analytic results. Using the characteristics of the incident X-rays of the model for solar X-ray flares, the spectrum, directivity and polarization of the reflected and the total X-ray fluxes are evaluated. The results are compared with observations.

  3. X-ray and TeV Gamma-Ray Emission from Parallel Electron-Positron or Electron-Proton Beams in BL Lac Objects

    CERN Document Server

    Krawczynski, H

    2006-01-01

    In this paper we discuss models of the X-rays and TeV gamma-ray emission from BL Lac objects based on parallel electron-positron or electron-proton beams that form close to the central black hole owing to the strong electric fields generated by the accretion disk and possibly also by the black hole itself. Fitting the energy spectrum of the BL Lac object Mrk 501, we obtain tight constrains on the beam properties. Launching a sufficiently energetic beam requires rather strong magnetic fields close to the black hole 100-1000 G. However, the model fits imply that the magnetic field in the emission region is only 0.02 G. Thus, the particles are accelerated close to the black hole and propagate a considerable distance before instabilities trigger the dissipation of energy through synchrotron and self-Compton emission. We discuss various approaches to generate enough power to drive the jet and, at the same time, to accelerate particles to 20 TeV energies. Although the parallel beam model has its own problems, it ex...

  4. X-Ray and TeV Gamma-Ray Emission from Parallel Electron-Positron or Electron-Proton Beams in BL Lacertae Objects

    Science.gov (United States)

    Krawczynski, H.

    2007-04-01

    In this paper we discuss models of the X-ray and TeV γ-ray emission from BL Lac objects based on parallel electron-positron or electron-proton beams that form close to the central black hole, due to the strong electric fields generated by the accretion disk and possibly also by the black hole itself. Fitting the energy spectrum of the BL Lac object Mrk 501, we obtain tight constraints on the beam properties. Launching a sufficiently energetic beam requires rather strong magnetic fields close to the black hole (~100-1000 G). However, the model fits imply that the magnetic field in the emission region is only ~0.02 G. Thus, the particles are accelerated close to the black hole and propagate a considerable distance before instabilities trigger the dissipation of energy through synchrotron and self-Compton emission. We discuss various approaches to generate enough power to drive the jet and, at the same time, to accelerate particles to ~20 TeV energies. Although the parallel beam model has its own problems, it explains some of the long-standing problems that plague models based on Fermi-type particle acceleration, such as the presence of a very high minimum Lorentz factor of accelerated particles. We conclude with a brief discussion of the implications of the model for the difference between the processes of jet formation in BL Lac-type objects and those in quasars.

  5. X-ray and TeV Gamma-Ray Emission from Parallel Electron-Positron or Electron-Proton Beams in BL Lac Objects

    Science.gov (United States)

    Krawczynski, Henric

    2007-04-01

    In this contribution we discuss models of the X-rays and TeV gamma-ray emission from BL Lac objects based on parallel electron-positron or electron-proton beams that form close to the central black hole owing to the strong electric fields generated by the accretion disk and possibly also by the black hole itself. Fitting the energy spectrum of the BL Lac object Mrk 501, we obtain tight constrains on the beam properties. Launching a sufficiently energetic beam requires rather strong magnetic fields close to the black hole 100-1000 G. However, the model fits imply that the magnetic field in the emission region is only 0.02 G. Thus, the particles are accelerated close to the black hole and propagate a considerable distance before instabilities trigger the dissipation of energy through synchrotron and self-Compton emission. We discuss various approaches to generate enough power to drive the jet and, at the same time, to accelerate particles to 20 TeV energies. Although the parallel beam model has its own problems, it explains some of the long-standing problems that plague models based on Fermi type particle acceleration, like the presence of a very high minimum Lorentz factor of accelerated particles. We conclude with a brief discussion of the implications of the model for the difference between the processes of jet formation in BL Lac type objects and in quasars.

  6. X-Ray Polarimetry

    CERN Document Server

    Kaaret, Philip

    2014-01-01

    We review the basic principles of X-ray polarimetry and current detector technologies based on the photoelectric effect, Bragg reflection, and Compton scattering. Recent technological advances in high-spatial-resolution gas-filled X-ray detectors have enabled efficient polarimeters exploiting the photoelectric effect that hold great scientific promise for X-ray polarimetry in the 2-10 keV band. Advances in the fabrication of multilayer optics have made feasible the construction of broad-band soft X-ray polarimeters based on Bragg reflection. Developments in scintillator and solid-state hard X-ray detectors facilitate construction of both modular, large area Compton scattering polarimeters and compact devices suitable for use with focusing X-ray telescopes.

  7. Development of a bent Laue beam-expanding double-crystal monochromator for biomedical X-ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Martinson, Mercedes, E-mail: mercedes.m@usask.ca [University of Saskatchewan, 116 Science Place, Room 163, Saskatoon, Saskatchewan (Canada); Samadi, Nazanin [University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan (Canada); Belev, George [Canadian Light Source, 44 Innovation Boulevard, Saskatoon, Saskatchewan (Canada); Bassey, Bassey [University of Saskatchewan, 116 Science Place, Room 163, Saskatoon, Saskatchewan (Canada); Lewis, Rob [University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan (Canada); Monash University, Clayton, Victoria 3800 (Australia); Aulakh, Gurpreet [University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan (Canada); Chapman, Dean [University of Saskatchewan, 116 Science Place, Room 163, Saskatoon, Saskatchewan (Canada); University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan (Canada)

    2014-03-13

    A bent Laue beam-expanding double-crystal monochromator was developed and tested at the Biomedical Imaging and Therapy beamline at the Canadian Light Source. The expander will reduce scanning time for micro-computed tomography and allow dynamic imaging that has not previously been possible at this beamline. The Biomedical Imaging and Therapy (BMIT) beamline at the Canadian Light Source has produced some excellent biological imaging data. However, the disadvantage of a small vertical beam limits its usability in some applications. Micro-computed tomography (micro-CT) imaging requires multiple scans to produce a full projection, and certain dynamic imaging experiments are not possible. A larger vertical beam is desirable. It was cost-prohibitive to build a longer beamline that would have produced a large vertical beam. Instead, it was proposed to develop a beam expander that would create a beam appearing to originate at a source much farther away. This was accomplished using a bent Laue double-crystal monochromator in a non-dispersive divergent geometry. The design and implementation of this beam expander is presented along with results from the micro-CT and dynamic imaging tests conducted with this beam. Flux (photons per unit area per unit time) has been measured and found to be comparable with the existing flat Bragg double-crystal monochromator in use at BMIT. This increase in overall photon count is due to the enhanced bandwidth of the bent Laue configuration. Whilst the expanded beam quality is suitable for dynamic imaging and micro-CT, further work is required to improve its phase and coherence properties.

  8. Study of X-Ray and $\\gamma$-Ray Spectra from Antiprotonic Atoms at the Slowly Extracted Antiproton Beam of LEAR

    CERN Multimedia

    2002-01-01

    This experiment will study the X-ray spectra of antiprotonic atoms and the $\\gamma$ spectra of residual nuclei after the antiproton absorption. We intend to begin with measurements on selected isotopically pure targets. Strong interaction effects, the antiproton absorption and the atomic cascade are analysed through the measurement of energies, lineshapes, relative and absolute intensities of all observable lines. The experiments are continued to determine st in resolved fine structure levels and in different isotopes of the same element. Coincidence techniques may be applied. All components of the experimental set-up are already existing from previous experiments and we could begin the measurements with any slowly extracted beam of low energy at LEAR.

  9. X-ray photoelectron spectroscopic study of the oxide removal mechanism of GaAs /100/ molecular beam epitaxial substrates in in situ heating

    Science.gov (United States)

    Vasquez, R. P.; Lewis, B. F.; Grunthaner, F. J.

    1983-01-01

    A standard cleaning procedure for GaAs (100) molecular beam epitaxial (MBE) substrates is a chemical treatment with a solution of H2SO4/H2O2/H2O, followed by in situ heating prior to MBE growth. X-ray photoelectron spectroscopic (XPS) studies of the surface following the chemical treatment show that the oxidized As is primarily As(+ 5). Upon heating to low temperatures (less than (350 C) the As(+ 5) oxidizes the substrate to form Ga2O3 and elemental As, and the As(+ 5) is reduced to As(+ 3) in the process. At higher temperatures (500 C), the As(+ 3) and elemental As desorb, while the Ga(+ 3) begins desorbing at about 600 C.

  10. Achieving high-resolution soft-tissue imaging with cone-beam CT: a two-pronged approach for modulation of x-ray fluence and detector gain

    Science.gov (United States)

    Graham, S. A.; Siewerdsen, J. H.; Moseley, D. J.; Keller, H.; Shkumat, N. A.; Jaffray, D. A.

    2005-04-01

    Cone-beam computed tomography (CBCT) presents a highly promising and challenging advanced application of flat-panel detectors (FPDs). The great advantage of this adaptable technology is in the potential for sub-mm 3D spatial resolution in combination with soft-tissue detectability. While the former is achieved naturally by CBCT systems incorporating modern FPD designs (e.g., 200 - 400 um pixel pitch), the latter presents a significant challenge due to limitations in FPD dynamic range, large field of view, and elevated levels of x-ray scatter in typical CBCT configurations. We are investigating a two-pronged strategy to maximizing soft-tissue detectability in CBCT: 1) front-end solutions, including novel beam modulation designs (viz., spatially varying compensators) that alleviate detector dynamic range requirements, reduce x-ray scatter, and better distribute imaging dose in a manner suited to soft-tissue visualization throughout the field of view; and 2) back-end solutions, including implementation of an advanced FPD design (Varian PaxScan 4030CB) that features dual-gain and dynamic gain switching that effectively extends detector dynamic range to 18 bits. These strategies are explored quantitatively on CBCT imaging platforms developed in our laboratory, including a dedicated CBCT bench and a mobile isocentric C-arm (Siemens PowerMobil). Pre-clinical evaluation of improved soft-tissue visibility was carried out in phantom and patient imaging with the C-arm device. Incorporation of these strategies begin to reveal the full potential of CBCT for soft-tissue visualization, an essential step in realizing broad utility of this adaptable technology for diagnostic and image-guided procedures.

  11. SU-E-T-143: Effect of X-Ray and Cone Beam CT Reconstruction Parameters On Estimation of Bone Volume of Mice Used in Aging Research

    Energy Technology Data Exchange (ETDEWEB)

    Russ, M; Pang, M; Troen, B; Rudin, S; Ionita, C [University at Buffalo, Buffalo, NY (United States)

    2014-06-01

    Purpose: To investigate the variations in bone volume calculations in mice involved in aging research when changing cone beam micro-CT x-ray and reconstruction parameters. Methods: Mouse spines were placed on an indexed turn table that rotated 0.5° per projection and imaged by a self-built micro CT machine containing a CCD-based high-resolution x-ray detector. After the full 360° rotation data set of object images was obtained, a standard filtered back-projection cone beam reconstruction was performed. Four different kVp's between 40–70 kVp in 10kVp increments were selected. For each kVp two mAs settings were used. Each acquisition was reconstructed using two voxel sizes (12 and 25μm) and two step angles, 0.5° and 1°, respectively. A LabView program was written to determine the total bone volume contained in the mouse's total spine volume (bone plus gaps) as a measure of spine health. First, the user selected the desired 512×512 reconstruction to view the whole spine volume which was then used to select a gray-level threshold that allowed for viewing of the bone structure, then another threshold to include gaps. The program returned bone volume, bone × gap volume, and their ratio, BVF. Results: The calculated bone volume fractions were compared as a function of tube potential. Cases with 25μm slice thickness showed trials with lower kVp's had greater image contrast, which resulted in higher calculated bone volume fractions. Cases with 12μm reconstructed slice thickness were significantly noisier, and showed no clear maximum BVF. Conclusion: Using the projection images and reconstructions acquired from the micro CT, it can be shown that the micro-CT x-ray and reconstruction parameters significantly affect the total bone volume calculations. When comparing mice cohorts treated with different therapies researchers need to be aware of such details and use volumes which were acquired and processed in identical conditions.

  12. ITAR: A modified TAR method to determine depth dose distribution for an ophthalmic device that performs kilovoltage x-ray pencil-beam stereotaxy

    Energy Technology Data Exchange (ETDEWEB)

    Hanlon, Justin, E-mail: jhanlon@orayainc.com; Chell, Erik; Firpo, Michael; Koruga, Igor [Oraya Therapeutics, Inc., Newark, California 94560 (United States)

    2014-02-15

    Purpose: New technology has been developed to treat age-related macular degeneration (AMD) using 100 kVp pencil-beams that enter the patient through the radio-resistant sclera with a depth of interest between 1.6 and 2.6 cm. Measurement of reference and relative dose in a kilovoltage x-ray beam with a 0.42 cm diameter field size and a 15 cm source to axis distance (SAD) is a challenge that is not fully addressed in current guidelines to medical physicists. AAPM's TG-61 gives dosimetry recommendations for low and medium energy x-rays, but not all of them are feasible to follow for this modality. Methods: An investigation was conducted to select appropriate equipment for the application. PTW's Type 34013 Soft X-Ray Chamber (Freiburg, Germany) and CIRS's Plastic Water LR (Norfolk, VA) were found to be the best available options. Attenuation curves were measured with minimal scatter contribution and thus called Low Scatter Tissue Air Ratio (LSTAR). A scatter conversion coefficient (C{sub scat}) was derived through Monte Carlo radiation transport simulation using MCNPX (LANL, Los Alamos, NM) to quantify the difference between a traditional TAR curve and the LSTAR curve. A material conversion coefficient (C{sub mat}) was determined through experimentation to evaluate the difference in attenuation properties between water and Plastic Water LR. Validity of performing direct dosimetry measurements with a source to detector distance other than the treatment distance, and therefore a different field size due to a fixed collimator, was explored. A method—Integrated Tissue Air Ratio (ITAR)—has been developed that isolates each of the three main radiological effects (distance from source, attenuation, and scatter) during measurement, and integrates them to determine the dose rate to the macula during treatment. Results: LSTAR curves were determined to be field size independent within the range explored, indicating that direct dosimetry measurements may be

  13. Experimental x-ray ghost imaging

    CERN Document Server

    Pelliccia, Daniele; Scheel, Mario; Cantelli, Valentina; Paganin, David M

    2016-01-01

    We report an experimental proof of principle for ghost imaging in the hard x-ray energy range. We used a synchrotron x-ray beam that was split using a thin crystal in Laue diffraction geometry. With an ultra-fast imaging camera, we were able to image x-rays generated by isolated electron bunches. At this time scale, the shot noise of the synchrotron emission process is measurable as speckles, leading to speckle correlation between the two beams. The integrated transmitted intensity from a sample located in the first beam was correlated with the spatially resolved intensity measured on the second, empty, beam to retrieve the shadow of the sample. The demonstration of ghost imaging with hard x-rays may open the way to protocols to reduce radiation damage in medical imaging and in non-destructive structural characterization using Free Electron Lasers.

  14. Experimental X-Ray Ghost Imaging

    Science.gov (United States)

    Pelliccia, Daniele; Rack, Alexander; Scheel, Mario; Cantelli, Valentina; Paganin, David M.

    2016-09-01

    We report an experimental proof of principle for ghost imaging in the hard-x-ray energy range. We use a synchrotron x-ray beam that is split using a thin crystal in Laue diffraction geometry. With an ultrafast imaging camera, we are able to image x rays generated by isolated electron bunches. At this time scale, the shot noise of the synchrotron emission process is measurable as speckles, leading to speckle correlation between the two beams. The integrated transmitted intensity from a sample located in the first beam is correlated with the spatially resolved intensity measured in the second, empty, beam to retrieve the shadow of the sample. The demonstration of ghost imaging with hard x rays may open the way to protocols to reduce radiation damage in medical imaging and in nondestructive structural characterization using free electron lasers.

  15. Ultrashort X-ray pulse science

    Energy Technology Data Exchange (ETDEWEB)

    Chin, Alan Hap [Univ. of California, Berkeley, CA (US). Dept. of Physics; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    1998-05-01

    A variety of phenomena involves atomic motion on the femtosecond time-scale. These phenomena have been studied using ultrashort optical pulses, which indirectly probe atomic positions through changes in optical properties. Because x-rays can more directly probe atomic positions, ultrashort x-ray pulses are better suited for the study of ultrafast structural dynamics. One approach towards generating ultrashort x-ray pulses is by 90{sup o} Thomson scattering between terawatt laser pulses and relativistic electrons. Using this technique, the author generated {approx} 300 fs, 30 keV (0.4 {angstrom}) x-ray pulses. These x-ray pulses are absolutely synchronized with ultrashort laser pulses, allowing femtosecond optical pump/x-ray probe experiments to be performed. Using the right-angle Thomson scattering x-ray source, the author performed time-resolved x-ray diffraction studies of laser-perturbated InSb. These experiments revealed a delayed onset of lattice expansion. This delay is due to the energy relaxation from a dense electron-hole plasma to the lattice. The dense electron-hole plasma first undergoes Auger recombination, which reduces the carrier concentration while maintaining energy content. Longitudinal-optic (LO) phonon emission then couples energy to the lattice. LO phonon decay into acoustic phonons, and acoustic phonon propagation then causes the growth of a thermally expanded layer. Source characterization is instrumental in utilizing ultrashort x-ray pulses in time-resolved x-ray spectroscopies. By measurement of the electron beam diameter at the generation point, the pulse duration of the Thomson scattered x-rays is determined. Analysis of the Thomson scattered x-ray beam properties also provides a novel means of electron bunch characterization. Although the pulse duration is inferred for the Thomson scattering x-ray source, direct measurement is required for other x-ray pulse sources. A method based on the laser-assisted photoelectric effect (LAPE) has

  16. Characteristic parameters analysis on diagnostic X-ray beams for dosemeter calibration; Analise de parametros caracteristicos de feixes de raios-X diagnostico para calibracao de dosimetros

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Paulo Marcio Campos de

    2008-07-01

    Ionizing radiation metrology is the base to achieve reliable dose measurements in ali areas; it is also part of the framework that is established to assure radiation protection procedures in order to avoid or minimize the harmful biological effect that may be caused by ionizing radiation. A well done metrology means the use of reliable instruments that comply with standard performance requirements worldwide accepted. Those instruments are expected to be calibrated by Metrology Laboratories under well defined conditions. The International Electrotechnical Commission (IEC) in Standard 61267 established the reference radiations for medical diagnostic x-ray equipment that are recommended to be used for calibrating dosimetric systems for diagnostic dosimetry. In this work, X-ray beam qualities were established in a Calibration Laboratory and their characteristics were analyzed through the measurement of beam parameters like inherent tube filtration, beam uniformity and field size, energy spectra and peak voltage for additional filtration with 94.425 por cent and 99.999 por cent purity filters. Also, the first half-value layer and the homogeneity coefficient were measured for the three RQR 2, RQR 6 and RQR 10 IEC beam qualities and they were analyzed according to the IEC standard. Air-kerma measurements were carried out with an ionization chamber that had its reliability confirmed through repetition and reproducibility reading tests. In 50 sets of measurements the maximum standard deviation found of 10 successive readings was 0.19 %; the maximum shift of the reading mean value at a fixed geometry condition was 0.80 % with an overall standard deviation of 0.23 %. Results showed that the use of different purity filters did not cause a relevant influence on the beam energy spectra. An ionization chamber was also calibrated against a standard dosimeter in ali implemented reference radiations and the relevant sources of uncertainties were estimated. Calibration could be done

  17. SU-D-BRF-01: Applications of Photonuclear Activation of Biological Tissues in Clinical High-Energy X-Ray Beams

    Energy Technology Data Exchange (ETDEWEB)

    Veltchev, I; Fourkal, E; Ma, C [Fox Chase Cancer Center, Philadelphia, PA (United States)

    2014-06-01

    Purpose: The commercial availability of high-energy accelerators opens new therapeutic opportunities for X-rays with energies in excess of 15MV. Three clinical beams (Varian 18MV, Elekta SL25, and Top Grade LA45) were compared by the production of photo-activated positron emitters in five types of biological tissues. Methods: The activation studies were performed using FLUKA2011 Monte Carlo suite with beam models designed for the three accelerators. Absolute activity density (Bq/ml) distribution in space was obtained from this study. Additionally, the temporal evolution of all activated species was monitored for cooling times up to 30 minutes. Results: The relative activation contrast of tissue pairs was evaluated for 2Gy of dose at 10cm depth for five tissues (normal, hypoxic, adipose, bone, and lung). In bone the sort-lived isotopes O-15 and P-30 dominated the activity at the early cooling stages. In all tissues 15 minutes post-irradiation the C-11 activity became dominant. Tissues with higher carbon-to-oxygen ratio in their elemental composition became clearly visible in a PET scan at longer cooling times. Radiation treatment of a lung tumor with a hypoxic core was simulated in an anthropomorphic phantom using the LA45 beam model. Increase in the PET counts by more than 50% was measured in the hypoxic volume 15 minutes post-irradiation, demonstrating the benefits of the relative activation contrast concept. Conclusion: LA45 beam is found to produce measurable activation distribution for 2Gy of dose, suitable for tissue type discrimination studies. Maximum activation contrast of 1.7 between hypoxic and normal tissues was measured in a simulated treatment. The absolute activity density values obtained from these Monte Carlo studies suggest that the window of opportunity for a PET scan exists up to 60 minutes after 2Gy of dose is deposited by 45MV X-ray beam. Lung-to-tissue activation contrast can be explored for treatment QA purposes as well.

  18. Parametric X-rays at FAST

    Energy Technology Data Exchange (ETDEWEB)

    Sen, Tanaji [Fermilab

    2016-06-01

    We discuss the generation of parametric X-rays (PXR) in the photoinjector at the new FAST facility at Fermilab. Detailed calculations of the intensity spectrum, energy and angular widths and spectral brilliance with a diamond crystal are presented. We also report on expected results with PXR generated while the beam is channeling. The low emittance electron beam makes this facility a promising source for creating brilliant X-rays.

  19. Study of x-rays produced from debris-free sources with Ar, Kr and Kr/Ar mixture linear gas jets irradiated by UNR Leopard laser beam with fs and ns pulse duration

    Science.gov (United States)

    Kantsyrev, V. L.; Schultz, K. A.; Shlyaptseva, V. V.; Safronova, A. S.; Shrestha, I. K.; Petrov, G. M.; Moschella, J. J.; Petkov, E. E.; Stafford, A.; Cooper, M. C.; Weller, M. E.; Cline, W.; Wiewior, P.; Chalyy, O.

    2016-06-01

    Experiments of x-ray emission from Ar, Kr, and Ar/Kr gas jet mixture were performed at the UNR Leopard Laser Facility operated with 350 fs pulses at laser intensity of 2 × 1019 W/cm2 and 0.8 ns pulses at an intensity of 1016 W/cm2. Debris free x-ray source with supersonic linear nozzle generated clusters/monomer jet with an average density of ≥1019 cm-3 was compared to cylindrical tube subsonic nozzle, which produced only monomer jet with average density 1.5-2 times higher. The linear (elongated) cluster/gas jet provides the capability to study x-ray yield anisotropy and laser beam self-focusing with plasma channel formation that are interconnecting with efficient x-ray generation. Diagnostics include x-ray diodes, pinhole cameras and spectrometers. It was observed that the emission in the 1-9 keV spectral region was strongly anisotropic depending on the directions of laser beam polarization for sub-ps laser pulse and supersonic linear jet. The energy yield in the 1-3 keV region produced by a linear nozzle was an order of magnitude higher than from a tube nozzle. Non-LTE models and 3D molecular dynamic simulations of Ar and Kr clusters irradiated by sub-ps laser pulses have been implemented to analyze obtained data. A potential evidence of electron beam generation in jets' plasma was discussed. Note that the described debris-free gas-puff x-ray source can generate x-ray pulses in a high repetition regime. This is a great advantage compared to solid laser targets.

  20. X-ray source for mammography

    Science.gov (United States)

    Logan, Clinton M.

    1994-01-01

    An x-ray source utilizing anode material which shifts the output spectrum to higher energy and thereby obtains higher penetrating ability for screening mammography application, than the currently utilized anode material. The currently used anode material (molybdenum) produces an energy x-ray spectrum of 17.5/19.6 keV, which using the anode material of this invention (e.g. silver, rhodium, and tungsten) the x-ray spectrum would be in the 20-35 keV region. Thus, the anode material of this invention provides for imaging of breasts with higher than average x-ray opacity without increase of the radiation dose, and thus reduces the risk of induced breast cancer due to the radiation dose administered for mammograms.

  1. Verification of TG-61 dose for synchrotron-produced monochromatic x-ray beams using fluence-normalized MCNP5 calculations

    CERN Document Server

    Brown, Thomas A D; Alvarez, Diane; Matthews, Kenneth L; Ham, Kyungmin; 10.1118/1.4761870

    2012-01-01

    Ion chamber dosimetry is being used to calibrate dose for cell irradiations designed to investigate photoactivated Auger electron therapy at the Louisiana State University CAMD synchrotron facility. This study performed a dosimetry intercomparison for synchrotron-produced monochromatic x-ray beams at 25 and 35 keV. Ion chamber depth-dose measurements in a PMMA phantom were compared with the product of MCNP5 Monte Carlo calculations of dose per fluence and measured incident fluence. Monochromatic beams of 25 and 35 keV were generated on the tomography beamline at CAMD. A cylindrical, air-equivalent ion chamber was used to measure the ionization created in a 10x10x10-cm3 PMMA phantom for depths from 0.6 to 7.7 cm. The American Association of Physicists in Medicine TG-61 protocol was applied to convert measured ionization into dose. Photon fluence was determined using a NaI detector to make scattering measurements of the beam from a thin polyethylene target at angles 30 degrees to 60 degrees. Differential Compto...

  2. Some specific features of ionization chamber calibrations in linac x-ray beams at the LNE-LNHB.

    Science.gov (United States)

    Delaunay, F; Ostrowsky, A

    2007-05-07

    The purpose of this note is to give some details about the modus operandi employed today to calibrate ionization chambers in radiotherapy linac photon beams at the Laboratoire National Henri Becquerel (LNE-LNHB). Some specific features are described: first the equipment (including the external monitoring ionization chambers), second the calculations of the profile or radial non-uniformity correction factors (up to 0.5% effect for commonly used ionization chambers) and finally the calculations to get the calibration coefficients for customer beam qualities.

  3. Ensuring convergence in total-variation-based reconstruction for accurate microcalcification imaging in breast X-ray CT

    DEFF Research Database (Denmark)

    Jørgensen, Jakob Heide; Sidky, Emil Y.; Pan, Xiaochuan

    2011-01-01

    , shows potential for reconstruction from sparse-view data. For iterative methods it is important to ensure convergence to an accurate solution, since important diagnostic image features, such as presence of microcalcifications indicating breast cancer, may not be visible in a non-converged reconstruction......, and this can have clinical significance. To prevent excessively long computational times, which is a practical concern for the large image arrays in CT, it is desirable to keep the number of iterations low, while still ensuring a sufficiently accurate reconstruction for the specific imaging task....... This motivates the study of accurate convergence criteria for iterative image reconstruction. In simulation studies with a realistic breast phantom with microcalcifications we investigate the issue of ensuring sufficiently converged solution for reliable reconstruction. Our results show that it can...

  4. Dental x-rays

    Science.gov (United States)

    ... X-rays are a form of high energy electromagnetic radiation. The x-rays penetrate the body to form ... for detecting cavities, unless the decay is very advanced and deep. Many ... The amount of radiation given off during the procedure is less than ...

  5. The clinical value of the mammography X-ray, ultrasound and MRI for the qualitative diagnosis of breast cancer%钼靶X射线、超声及MRI对乳腺癌诊断的应用价值

    Institute of Scientific and Technical Information of China (English)

    赵军

    2014-01-01

    Objective:To evaluate the diagnostic value of the mammography X-ray, ultrasound and MRI for breast cancer, expected to provide a reference for the clinical diagnosis of these diseases. Methods:117 cases patients with suspected breast cancer were the objects of the study, compared the results of the detection with mammography X-ray, ultrasound and MRI between the results of pathological examination, to investigate the diagnostic ability of different image means for all types of breast disease.Results:The sensitivity, accuracy of MRI for breast cancer were better than X-ray mammography and ultrasound, but the speciifcity was similar with X-ray mammography. Compared ultrasound, the specificity, positive predictive value of X-ray mammography was much higher, but had no advantage in the other parameters related with diagnostic capabilities.Conclusions:Mammography X-ray, ultrasound and MRI have their own advantages and disadvantages for the diagnosis of breast diseases, but the mammography X-ray can be as the preferred means for the ifrst diagnosis of breast cancer, and multiple imaging means could be joint based on the needs of clinical diagnosis.%目的:探讨钼靶X射线、超声及MRI对乳腺癌的临床诊断价值。方法:以117例疑似乳腺癌患者为研究对象,将钼靶X射线、超声及MRI检查结果与病理诊断结果对比,考察不同影像手段对各类乳腺疾病的诊断能力。结果:MRI对乳腺癌的敏感性、准确度等均优于钼靶X射线和超声,但特异性与钼靶X射线相当。与超声相比,钼靶X射线的特异性、阳性预测值较高,但在其他诊断能力相关的参数方面则无优势。结论:钼靶X射线、超声及MRI在诊断乳腺疾病方面各有优劣,但钼靶X射线可作为乳腺癌临床初诊的首选手段,临床确诊时可联用多种影像手段。

  6. Stellar X-Ray Polarimetry

    Science.gov (United States)

    Swank, J.

    2011-01-01

    Most of the stellar end-state black holes, pulsars, and white dwarfs that are X-ray sources should have polarized X-ray fluxes. The degree will depend on the relative contributions of the unresolved structures. Fluxes from accretion disks and accretion disk corona may be polarized by scattering. Beams and jets may have contributions of polarized emission in strong magnetic fields. The Gravity and Extreme Magnetism Small Explorer (GEMS) will study the effects on polarization of strong gravity of black holes and strong magnetism of neutron stars. Some part of the flux from compact stars accreting from companion stars has been reflected from the companion, its wind, or accretion streams. Polarization of this component is a potential tool for studying the structure of the gas in these binary systems. Polarization due to scattering can also be present in X-ray emission from white dwarf binaries and binary normal stars such as RS CVn stars and colliding wind sources like Eta Car. Normal late type stars may have polarized flux from coronal flares. But X-ray polarization sensitivity is not at the level needed for single early type stars.

  7. X-Ray Surveys

    CERN Document Server

    Giommi, P; Perri, M

    1998-01-01

    A review of recent developments in the field of X-ray surveys, especially in the hard (2-10 and 5-10 keV) bands, is given. A new detailed comparison between the measurements in the hard band and extrapolations from ROSAT counts, that takes into proper account the observed distribution of spectral slopes, is presented. Direct comparisons between deep ROSAT and BeppoSAX images show that most hard X-ray sources are also detected at soft X-ray energies. This may indicate that heavily cutoff sources, that should not be detectable in the ROSAT band but are expected in large numbers from unified AGN schemes, are in fact detected because of the emerging of either non-nuclear components, or of reflected, or partially transmitted nuclear X-rays. These soft components may complicate the estimation of the soft X-ray luminosity function and cosmological evolution of AGN.

  8. A graphite calorimeter for absolute measurements of absorbed dose to water: application in medium-energy x-ray filtered beams.

    Science.gov (United States)

    Pinto, M; Pimpinella, M; Quini, M; D'Arienzo, M; Astefanoaei, I; Loreti, S; Guerra, A S

    2016-02-21

    The Italian National Institute of Ionizing Radiation Metrology (ENEA-INMRI) has designed and built a graphite calorimeter that, in a water phantom, has allowed the determination of the absorbed dose to water in medium-energy x-rays with generating voltages from 180 to 250 kV. The new standard is a miniaturized three-bodies calorimeter, with a disc-shaped core of 21 mm diameter and 2 mm thickness weighing 1.134 g, sealed in a PMMA waterproof envelope with air-evacuated gaps. The measured absorbed dose to graphite is converted into absorbed dose to water by means of an energy-dependent conversion factor obtained from Monte Carlo simulations. Heat-transfer correction factors were determined by FEM calculations. At a source-to-detector distance of 100 cm, a depth in water of 2 g cm(-2), and at a dose rate of about 0.15 Gy min(-1), results of calorimetric measurements of absorbed dose to water, D(w), were compared to experimental determinations, D wK, obtained via an ionization chamber calibrated in terms of air kerma, according to established dosimetry protocols. The combined standard uncertainty of D(w) and D(wK) were estimated as 1.9% and 1.7%, respectively. The two absorbed dose to water determinations were in agreement within 1%, well below the stated measurement uncertainties. Advancements are in progress to extend the measurement capability of the new in-water-phantom graphite calorimeter to other filtered medium-energy x-ray qualities and to reduce the D(w) uncertainty to around 1%. The new calorimeter represents the first implementation of in-water-phantom graphite calorimetry in the kilovoltage range and, allowing independent determinations of D(w), it will contribute to establish a robust system of absorbed dose to water primary standards for medium-energy x-ray beams.

  9. SU-E-T-537: Comparison of Intra-Operative Soft X-Rays to Low Energy Electron Beams for Treatment of Superficial Lesions

    Energy Technology Data Exchange (ETDEWEB)

    Chinsky, B; Diak, A; Gros, S; Sethi [Loyola UniversityMedical Center, Maywood, IL (United States)

    2014-06-01

    Purpose: Superficial soft x-ray applicators have recently been designed for use with existing intra-operative radiotherapy systems. These applicators may be used in treating superficial lesions which are conventionally treated with electron beams. The purpose of this abstract is to compare dose distributions of an intra-operative 50kV x-ray unit with low energy electrons for the treatment of superficial lesions. Methods: Dosimetric parameters for 1 and 3-cm diameter Intrabeam superficial x-ray applicators were measured with EBT3 Gafchromic film in a solid water phantom. Depth dose distributions and profiles (d=2, 5, 10 and 15mm) were obtained by prescribing a dose of 400cGy at 5mm depth below the phantom surface. Corresponding dose profiles for 6-MeV electrons were acquired from a Varian Clinac 21EX at 100 SSD. H and D calibration curves were generated for each modality for 0-800cGy. Results: Dose coverage, penumbra, dose uniformity, surface dose, and dose fall-off were examined. Compared to electrons, Intrabeam lateral dose coverage at 5mm depth was 70% larger with a much sharper (1/4) penumbra. Electron isodose levels bulged with depth, whereas Intrabeam isodose levels exhibited a convex cone shape. The Intrabeam dose profiles demonstrated horns in the dose distribution up to a 5mm depth and an exponential dose fall-off. Relative surface dose was higher for the Intrabeam applicators. Treatment times were comparable for both modalities. Conclusions: The very small penumbra of Intrabeam at shallow depths could be useful in treating superficial lesions adjacent to critical structures. The exponential dose fall-off of Intrabeam makes it appealing in the sparing of structures beyond the lesion. However, for lesions past a depth of 5mm, electrons would be desirable as they penetrate farther and provide skin sparing. Intrabeam may be preferable for sites that are difficult to treat with electrons due to mechanical and physical limitations.

  10. Molecular beam epitaxy of GeTe-Sb{sub 2}Te{sub 3} phase change materials studied by X-ray diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Shayduk, Roman

    2010-05-20

    The integration of phase change materials into semiconductor heterostructures may lead to the development of a new generation of high density non-volatile phase change memories. Epitaxial phase change materials allow to study the detailed structural changes during the phase transition and to determine the scaling limits of the memory. This work is dedicated to the epitaxial growth of Ge-Sb-Te phase change alloys on GaSb(001). We deposit Ge-Sb-Te (GST) films on GaSb(001) substrates by means of molecular beam epitaxy (MBE). The film orientation and lattice constant evolution is determined in real time during growth using grazing incidence X-ray diffraction (GID). The nucleation stage of the growth is studied in situ using reflection high energy electron diffraction (RHEED). Four growth regimes of GST on GaSb(001) were observed: amorphous, polycrystalline, incubated epitaxial and direct epitaxial. Amorphous film grows for substrate temperatures below 100 C. For substrate temperatures in the range 100-160 C, the film grows in polycrystalline form. Incubated epitaxial growth is observed at temperatures from 180 to 210 C. This growth regime is characterized by an initial 0.6nm thick amorphous layer formation, which crystallizes epitaxially as the film thickness increases. The determined lattice constant of the films is 6.01 A, very close to that of the metastable GST phase. The films predominantly possess an epitaxial cube-on-cube relationship. At higher temperatures the films grow epitaxially, however the growth rate is rapidly decreasing with temperature. At temperatures above 270 C the growth rate is zero. The composition of the grown films is close to 2:2:5 for Ge, Sb and Te, respectively. The determined crystal structure of the films is face centered cubic (FCC) with a rhombohedral distortion. The analysis of X-ray peak widths gives a value for the rhombohedral angle of 89.56 . We observe two types of reflections in reciprocal space indicating two FCC sublattices in

  11. Observation of femtosecond X-ray interactions with matter using an X-ray-X-ray pump-probe scheme.

    Science.gov (United States)

    Inoue, Ichiro; Inubushi, Yuichi; Sato, Takahiro; Tono, Kensuke; Katayama, Tetsuo; Kameshima, Takashi; Ogawa, Kanade; Togashi, Tadashi; Owada, Shigeki; Amemiya, Yoshiyuki; Tanaka, Takashi; Hara, Toru; Yabashi, Makina

    2016-02-01

    Resolution in the X-ray structure determination of noncrystalline samples has been limited to several tens of nanometers, because deep X-ray irradiation required for enhanced resolution causes radiation damage to samples. However, theoretical studies predict that the femtosecond (fs) durations of X-ray free-electron laser (XFEL) pulses make it possible to record scattering signals before the initiation of X-ray damage processes; thus, an ultraintense X-ray beam can be used beyond the conventional limit of radiation dose. Here, we verify this scenario by directly observing femtosecond X-ray damage processes in diamond irradiated with extraordinarily intense (∼10(19) W/cm(2)) XFEL pulses. An X-ray pump-probe diffraction scheme was developed in this study; tightly focused double-5-fs XFEL pulses with time separations ranging from sub-fs to 80 fs were used to excite (i.e., pump) the diamond and characterize (i.e., probe) the temporal changes of the crystalline structures through Bragg reflection. It was found that the pump and probe diffraction intensities remain almost constant for shorter time separations of the double pulse, whereas the probe diffraction intensities decreased after 20 fs following pump pulse irradiation due to the X-ray-induced atomic displacement. This result indicates that sub-10-fs XFEL pulses enable conductions of damageless structural determinations and supports the validity of the theoretical predictions of ultraintense X-ray-matter interactions. The X-ray pump-probe scheme demonstrated here would be effective for understanding ultraintense X-ray-matter interactions, which will greatly stimulate advanced XFEL applications, such as atomic structure determination of a single molecule and generation of exotic matters with high energy densities.

  12. Assessment of flatness and symmetry of megavoltage x-ray beam with an electronic portal imaging device

    CERN Document Server

    Liu, G; Bezak, E

    2002-01-01

    The input/output characteristics of the Wellhofer BIS 710 electronic portal imaging device (EPID) have been investigated to establish its efficacy for periodic quality assurance (QA) applications. Calibration curves have been determined for the energy fluence incident on the detector versus the pixel values. The effect of the charge coupled device (CCD) camera sampling time and beam parameters (such as beam field size, dose rate, photon energy) on the calibration have been investigated for a region of interest (ROI) around the central beam axis. The results demonstrate that the pixel output is a linear function of the incident exposure, as expected for a video-based electronic portal imaging system. The field size effects of the BIS 710 are similar to that of an ion chamber for smaller field sizes up to 10 x 10 cm sup 2. However, for larger field sizes the pixel value increases more rapidly. Furthermore, the system is slightly sensitive to dose rate and is also energy dependent. The BIS 710 has been used in t...

  13. X-ray diffraction: instrumentation and applications.

    Science.gov (United States)

    Bunaciu, Andrei A; Udriştioiu, Elena Gabriela; Aboul-Enein, Hassan Y

    2015-01-01

    X-ray diffraction (XRD) is a powerful nondestructive technique for characterizing crystalline materials. It provides information on structures, phases, preferred crystal orientations (texture), and other structural parameters, such as average grain size, crystallinity, strain, and crystal defects. X-ray diffraction peaks are produced by constructive interference of a monochromatic beam of X-rays scattered at specific angles from each set of lattice planes in a sample. The peak intensities are determined by the distribution of atoms within the lattice. Consequently, the X-ray diffraction pattern is the fingerprint of periodic atomic arrangements in a given material. This review summarizes the scientific trends associated with the rapid development of the technique of X-ray diffraction over the past five years pertaining to the fields of pharmaceuticals, forensic science, geological applications, microelectronics, and glass manufacturing, as well as in corrosion analysis.

  14. High-energy transmission Laue micro-beam X-ray diffraction: a probe for intra-granular lattice orientation and elastic strain in thicker samples.

    Science.gov (United States)

    Hofmann, Felix; Song, Xu; Abbey, Brian; Jun, Tea-Sung; Korsunsky, Alexander M

    2012-05-01

    An understanding of the mechanical response of modern engineering alloys to complex loading conditions is essential for the design of load-bearing components in high-performance safety-critical aerospace applications. A detailed knowledge of how material behaviour is modified by fatigue and the ability to predict failure reliably are vital for enhanced component performance. Unlike macroscopic bulk properties (e.g. stiffness, yield stress, etc.) that depend on the average behaviour of many grains, material failure is governed by `weakest link'-type mechanisms. It is strongly dependent on the anisotropic single-crystal elastic-plastic behaviour, local morphology and microstructure, and grain-to-grain interactions. For the development and validation of models that capture these complex phenomena, the ability to probe deformation behaviour at the micro-scale is key. The diffraction of highly penetrating synchrotron X-rays is well suited to this purpose and micro-beam Laue diffraction is a particularly powerful tool that has emerged in recent years. Typically it uses photon energies of 5-25 keV, limiting penetration into the material, so that only thin samples or near-surface regions can be studied. In this paper the development of high-energy transmission Laue (HETL) micro-beam X-ray diffraction is described, extending the micro-beam Laue technique to significantly higher photon energies (50-150 keV). It allows the probing of thicker sample sections, with the potential for grain-level characterization of real engineering components. The new HETL technique is used to study the deformation behaviour of individual grains in a large-grained polycrystalline nickel sample during in situ tensile loading. Refinement of the Laue diffraction patterns yields lattice orientations and qualitative information about elastic strains. After deformation, bands of high lattice misorientation can be identified in the sample. Orientation spread within individual scattering volumes is

  15. Classification of breast tissue using a laboratory system for small-angle x-ray scattering (SAXS)

    Science.gov (United States)

    Sidhu, S.; Falzon, G.; Hart, S. A.; Fox, J. G.; Lewis, R. A.; Siu, K. K. W.

    2011-11-01

    Structural changes in breast tissue at the nanometre scale have been shown to differentiate between tissue types using synchrotron SAXS techniques. Classification of breast tissues using information acquired from a laboratory SAXS camera source could possibly provide a means of adopting SAXS as a viable diagnostic procedure. Tissue samples were obtained from surgical waste from 66 patients and structural components of the tissues were examined between q = 0.25 and 2.3 nm-1. Principal component analysis showed that the amplitude of the fifth-order axial Bragg peak, the magnitude of the integrated intensity and the full-width at half-maximum of the fat peak were significantly different between tissue types. A discriminant analysis showed that excellent classification can be achieved; however, only 30% of the tissue samples provided the 16 variables required for classification. This suggests that the presence of disease is represented by a combination of factors, rather than one specific trait. A closer examination of the amorphous scattering intensity showed not only a trend of increased scattering intensity with disease severity, but also a corresponding decrease in the size of the scatterers contributing to this intensity.

  16. X-ray crystallography

    Science.gov (United States)

    2001-01-01

    X-rays diffracted from a well-ordered protein crystal create sharp patterns of scattered light on film. A computer can use these patterns to generate a model of a protein molecule. To analyze the selected crystal, an X-ray crystallographer shines X-rays through the crystal. Unlike a single dental X-ray, which produces a shadow image of a tooth, these X-rays have to be taken many times from different angles to produce a pattern from the scattered light, a map of the intensity of the X-rays after they diffract through the crystal. The X-rays bounce off the electron clouds that form the outer structure of each atom. A flawed crystal will yield a blurry pattern; a well-ordered protein crystal yields a series of sharp diffraction patterns. From these patterns, researchers build an electron density map. With powerful computers and a lot of calculations, scientists can use the electron density patterns to determine the structure of the protein and make a computer-generated model of the structure. The models let researchers improve their understanding of how the protein functions. They also allow scientists to look for receptor sites and active areas that control a protein's function and role in the progress of diseases. From there, pharmaceutical researchers can design molecules that fit the active site, much like a key and lock, so that the protein is locked without affecting the rest of the body. This is called structure-based drug design.

  17. Molybdenum Target X Ray Film and MRI in the Diagnosis of Breast Diseases%钼靶X线片与MRI在诊断乳腺疾病上的对比观察

    Institute of Scientific and Technical Information of China (English)

    兰勇军; 毕力克孜; 陈琼

    2015-01-01

    目的:比较钼靶X线片与MRI在诊断乳腺疾病中的价值。方法本文通过分别分析钼靶X线检查与MRI检查在诊断乳腺疾病上的意义,比较钼靶X线片与MRI的优劣势。结果钼靶X线片检查是诊断乳腺疾病的金标准,MRI检查乳腺疾病具有较高的诊断率及敏感度。结论可将这两种检查方式结合使用,取长补短,提高乳腺疾病的诊断率,从而给予患者早期治疗干预,降低乳腺癌的发生,提高患者的生存质量。%Objective To comparare the values of X-ray mammography and MRI in the diagnosis of breast disease.Methods This text comparares the advantages and disadvantages of X-ray mammography and MRI by separately analyzing significances of X-ray mammography and MRI in the diagnosis of breast disease.ResultesMammography X-ray examination is the gold standard for the diagnosis of breast disease,while MRI has higher diagnosis rates and sensitivity in the examination of breast disease.Conclusion These two checks can be combined through drawing on each others' strength to improve the diagnosis rates of breast disease,giving patients early therapeutic intervention to reduce the occurrence of breast cancer and improve the quality of patients' life.

  18. Hard and soft x-ray study of the correlation between substrate quality and multilayer performance for Co/C coating produced by electron beam evaporation using ion polishing

    DEFF Research Database (Denmark)

    Abdali, S.; Christensen, Finn Erland; Spiller, E.;

    1995-01-01

    Polished silicon crystals, lacquered aluminum foil, and float glass substrates with respect to surface roughness. Co/C multilayers were then deposited by electron-beam evaporation with in situ monitoring x-ray signal and ion polishing (Kr+) for the metal layer. The specular as well...

  19. X-ray lasers

    CERN Document Server

    Elton, Raymond C

    2012-01-01

    The first in its field, this book is both an introduction to x-ray lasers and a how-to guide for specialists. It provides new entrants and others interested in the field with a comprehensive overview and describes useful examples of analysis and experiments as background and guidance for researchers undertaking new laser designs. In one succinct volume, X-Ray Lasers collects the knowledge and experience gained in two decades of x-ray laser development and conveys the exciting challenges and possibilities still to come._Add on for longer version of blurb_M>The reader is first introduced

  20. X-Ray Diffraction.

    Science.gov (United States)

    Smith, D. K.; Smith, K. L.

    1980-01-01

    Reviews applications in research and analytical characterization of compounds and materials in the field of X-ray diffraction, emphasizing new developments in applications and instrumentation in both single crystal and powder diffraction. Cites 414 references. (CS)

  1. Pelvis x-ray

    Science.gov (United States)

    X-ray - pelvis ... Tumors Degenerative conditions of bones in the hips, pelvis, and upper legs ... hip joint Tumors of the bones of the pelvis Sacroiliitis (inflammation of the area where the sacrum ...

  2. X-ray - skeleton

    Science.gov (United States)

    ... x-ray particles pass through the body. A computer or special film records the images. Structures that ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  3. Bone x-ray

    Science.gov (United States)

    ... or broken bone Bone tumors Degenerative bone conditions Osteomyelitis (inflammation of the bone caused by an infection) ... Multiple myeloma Osgood-Schlatter disease Osteogenesis imperfecta Osteomalacia Osteomyelitis Paget disease of the bone Rickets X-ray ...

  4. Hand x-ray

    Science.gov (United States)

    ... include fractures, bone tumors , degenerative bone conditions, and osteomyelitis (inflammation of the bone caused by an infection). ... chap 46. Read More Bone tumor Broken bone Osteomyelitis X-ray Review Date 9/8/2014 Updated ...

  5. Chest X-Ray

    Medline Plus

    Full Text Available ... breath, persistent cough, fever, chest pain or injury. It may also be useful to help diagnose and ... have some concerns about chest x-rays. However, it’s important to consider the likelihood of benefit to ...

  6. X-ray diffraction imaging of material microstructures

    KAUST Repository

    Varga, Laszlo

    2016-10-20

    Various examples are provided for x-ray imaging of the microstructure of materials. In one example, a system for non-destructive material testing includes an x-ray source configured to generate a beam spot on a test item; a grid detector configured to receive x- rays diffracted from the test object; and a computing device configured to determine a microstructure image based at least in part upon a diffraction pattern of the x-rays diffracted from the test object. In another example, a method for determining a microstructure of a material includes illuminating a beam spot on the material with a beam of incident x-rays; detecting, with a grid detector, x-rays diffracted from the material; and determining, by a computing device, a microstructure image based at least in part upon a diffraction pattern of the x-rays diffracted from the material.

  7. Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-wiggler-generated X rays.

    Science.gov (United States)

    Laissue, J A; Geiser, G; Spanne, P O; Dilmanian, F A; Gebbers, J O; Geiser, M; Wu, X Y; Makar, M S; Micca, P L; Nawrocky, M M; Joel, D D; Slatkin, D N

    1998-11-23

    Adult-rat-brain tissues display an unusually high resistance to necrosis when serially irradiated with parallel, thin slices of a microplanar (i.e., microscopically thin and macroscopically broad) beam of synchrotron-wiggler-generated, approx. 35-120 keV (median approx. 50 keV) Gd-filtered X rays at skin-entrance absorbed doses of 312 to 5000 Gy per slice. Such microplanar beams were used to irradiate young adult rats bearing right frontocerebral 9L gliosarcomas (approx. 4 mm diameter), through a volume of tissue containing the tumor and contiguous brain tissue, either in a single array or in 2 orthogonally crossed arrays of tissue slices. Each array included 101 parallel microplanar slices, 100 microm center-to-center distance, each slice being approx. 25 microm wide and 12 mm high, with skin-entrance absorbed doses of 312.5 Gy or 625 Gy per slice. Compared with unirradiated controls with a median survival time of 20 days after tumor initiation, the median survival time was extended in irradiated rats by 139 days (625 Gy, crossed arrays), 96 days (312 Gy, crossed arrays) or 24 days (625 Gy, single array). The tumors disappeared in 22 of the 36 irradiated rats, 4/11 even after unidirectional microbeam irradiation. The extent and severity of radiation damage to the normal brain in rats with or without tumor was graded histopathologically. Correlation of those grades with radiation doses shows that loss of tissue structure was confined to beam-crossing regions and that only minor damage was done to zones of the brain irradiated unidirectionally.

  8. The Analysis of Molybdenum X-ray Mammography in the Diagnosis of 33 Cases of Breast Cancer%乳腺癌的钼靶诊断33例分析

    Institute of Scientific and Technical Information of China (English)

    刘燕飞; 王国华; 罗庆华

    2013-01-01

      目的:总结本院乳腺钼靶摄片对诊断乳腺癌的经验,探讨钼靶X线检查及其影像表现对乳腺癌的诊断价值。方法:回顾性分析本院乳腺钼靶X线检查诊断怀疑为乳腺癌并有病理结果的33例患者的X线影像表现。结果:33例患者中,经手术病理确诊为乳腺癌的有23例(69.7%)。良性病例10例(30.3%),其中1例不典型增生,1例乳头状瘤伴不典型增生。结论:钼靶X线检查对乳腺癌的诊断有价值,也是目前能够及时发现并确诊乳腺癌的比较简单方便而又经济的方法。%Objective:To summarize the experience of the diagnosis of breast cancer with molybdenum X-ray mammography,to explore the diagnostic value of the molybdenum X-ray mammography and its imaging finding for the breast cancer.Method:Retrospective analysis of the breast molybdenum target X-ray diagnosis of X-ray images of 33 patients with suspected breast cancer and pathological results of performance.Result:In the 33 suspected breast cancer cases,23 cases by surgery pathology diagnosed with breast cancer(69.7%),other 10 cases of benign cases(30.3%),atypical hyperplasia 2 cases(6.1%).Conclusion:Molybdenum X-ray mammography is valuable in the diagnosis of breast cancer,and it is simple and economic method to timely discover and accurate diagnose the breast cancer at the moment.

  9. Modeling and characterization of X-ray yield in a polychromatic, lab-scale, X-ray computed tomography system

    Energy Technology Data Exchange (ETDEWEB)

    Mertens, J.C.E.; Chawla, Nikhilesh, E-mail: nchawla@asu.edu

    2015-05-21

    A modular X-ray computed micro-tomography (µXCT) system is characterized in terms of X-ray yield resulting both from the generated X-ray spectrum and from X-ray detection with an energy-sensitive detector. The X-ray computed tomography system is composed of a commercially available cone-beam microfocus X-ray source and a modular optically-coupled-CCD-scintillator X-ray detector. The X-ray yield is measured and reported in units independent from exposure time, X-ray tube beam target current, and cone-beam-to-detector geometry. The polychromatic X-ray source is modeled as a broad Bremsstrahlung X-ray spectrum in order to understand the effect of the controllable parameters, that is, X-ray tube accelerating voltage and X-ray beam filtering. An approach is adopted which expresses the absolute number of emitted X-rays. The response of the energy-sensitive detector to the modeled spectrum is modeled as a function of scintillator composition and thickness. The detection efficiency model for the polychromatic X-ray detector considers the response of the light collection system and the electronic imaging array in order to predict absolute count yield under the studied conditions. The modeling approach is applied to the specific hardware implemented in the current µXCT system. The model's predictions for absolute detection rate are in reasonable agreement with measured values under a range of conditions applied to the system for X-ray microtomography imaging, particularly for the LuAG:Ce scintillator material.

  10. X-ray diffraction contrast tomography (DCT) system, and an X-ray diffraction contrast tomography (DCT) method

    DEFF Research Database (Denmark)

    2012-01-01

    Source: US2012008736A An X-ray diffraction contrast tomography system (DCT) comprising a laboratory X-ray source (2), a staging device (5) rotating a polycrystalline material sample in the direct path of the X-ray beam, a first X-ray detector (6) detecting the direct X-ray beam being transmitted ...... in the polycrystalline sample is determined based on the two-dimensional position of extinction spots and the associated angular position of the sample for a set of extinction spots pertaining to the individual grain....

  11. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... that might interfere with the x-ray images. Women should always inform their physician and x-ray ... Safety page for more information about radiation dose. Women should always inform their physician or x-ray ...

  12. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... drawer under the table holds the x-ray film or image recording plate . Sometimes the x-ray ... extended over the patient while an x-ray film holder or image recording plate is placed beneath ...

  13. Iodine contrast cone beam CT imaging of breast cancer

    Science.gov (United States)

    Partain, Larry; Prionas, Stavros; Seppi, Edward; Virshup, Gary; Roos, Gerhard; Sutherland, Robert; Boone, John

    2007-03-01

    An iodine contrast agent, in conjunction with an X-ray cone beam CT imaging system, was used to clearly image three, biopsy verified, cancer lesions in two patients. The lesions were approximately in the 10 mm to 6 mm diameter range. Additional regions were also enhanced with approximate dimensions down to 1 mm or less in diameter. A flat panel detector, with 194 μm pixels in 2 x 2 binning mode, was used to obtain 500 projection images at 30 fps with an 80 kVp X-ray system operating at 112 mAs, for an 8-9 mGy dose - equivalent to two view mammography for these women. The patients were positioned prone, while the gantry rotated in the horizontal plane around the uncompressed, pendant breasts. This gantry rotated 360 degrees during the patient's 16.6 sec breath hold. A volume of 100 cc of 320 mg/ml iodine-contrast was power injected at 4 cc/sec, via catheter into the arm vein of the patient. The resulting 512 x 512 x 300 cone beam CT data set of Feldkamp reconstructed ~(0.3 mm) 3 voxels were analyzed. An interval of voxel contrast values, characteristic of the regions with iodine contrast enhancement, were used with surface rendering to clearly identify up to a total of 13 highlighted volumes. This included the three largest lesions, that were previously biopsied and confirmed to be malignant. The other ten highlighted regions, of smaller diameters, are likely areas of increased contrast trapping unrelated to cancer angiogenesis. However the technique itself is capable of resolving lesions that small.

  14. Dislocation generation related to micro-cracks in Si wafers: High temperature in situ study with white beam X-ray topography

    Energy Technology Data Exchange (ETDEWEB)

    Danilewsky, A., E-mail: a.danilewsky@krist.uni-freiburg.d [Kristallographie, Institut fuer Geowissenschaften, Universitaet, Freiburg (Germany); Wittge, J.; Hess, A.; Croell, A. [Kristallographie, Institut fuer Geowissenschaften, Universitaet, Freiburg (Germany); Allen, D.; McNally, P. [Research Institute for Networks and Communications Engineering, Dublin City University, Dublin (Ireland); Vagovic, P. [Institut fuer Synchrotronstrahlung, Research Centre Karlsruhe/KIT, Karlsruhe (Germany); Institute of Electrical Engineering, Slovak Academy Sciences, Bratislava (Slovakia); Cecilia, A. [Institut fuer Synchrotronstrahlung, Research Centre Karlsruhe/KIT, Karlsruhe (Germany); Li, Z. [Kristallographie, Institut fuer Geowissenschaften, Universitaet, Freiburg (Germany); Institut fuer Synchrotronstrahlung, Research Centre Karlsruhe/KIT, Karlsruhe (Germany); Baumbach, T. [Institut fuer Synchrotronstrahlung, Research Centre Karlsruhe/KIT, Karlsruhe (Germany); Gorostegui-Colinas, E.; Elizalde, M.R. [Centro de Estudios e Investigaciones Tecnicas de Gipuzkoa, CEIT and Tecnun (University of Navarra), San Sebastian (Spain)

    2010-02-15

    The generation and propagation of dislocations in Si at high temperature is observed in situ with white beam X-ray topography. For the heating experiments a double ellipsoidal mirror furnace was installed at the Topo-Tomo beamline of the ANKA synchrotron light source, Research Centre Karlsruhe, Germany. Details of the experimental set-up and the first results on the occurrence of dislocations are presented. Artificial damage was generated in commercial (1 0 0) Si wafers using a nanoindenter with various loads. The applied forces for each set of indents were varied from 100 to 500 mN, respectively. After heating to approx. 790 deg. C large area transmission topographs were taken every 30 min which were then compared to room temperature topographs before and after heating. At the outset straight 60 deg.-dislocations with b = a/2<1 1 0> originate from the 500 mN indents into the direction of the strongest temperature gradient. After 60 min at constant temperature an increase in the length and number of the dislocations in other directions is also observed. As a result of the continual thermal stressing dislocations develop from the 100 mN indents too.

  15. Design of an ultrahigh vacuum transfer mechanism to interconnect an oxide molecular beam epitaxy growth chamber and an x-ray photoemission spectroscopy analysis system.

    Science.gov (United States)

    Rutkowski, M M; McNicholas, K M; Zeng, Zhaoquan; Brillson, L J

    2013-06-01

    We designed a mechanism and the accompanying sample holders to transfer between a VEECO 930 oxide molecular beam epitaxy (MBE) and a PHI Versa Probe X-ray photoemission spectroscopy (XPS) chamber within a multiple station growth, processing, and analysis system through ultrahigh vacuum (UHV). The mechanism consists of four parts: (1) a platen compatible with the MBE growth stage, (2) a platen compatible with the XPS analysis stage, (3) a sample coupon that is transferred between the two platens, and (4) the accompanying UHV transfer line. The mechanism offers a robust design that enables transfer back and forth between the growth chamber and the analysis chamber, and yet is flexible enough to allow transfer between standard sample holders for thin film growth and masked sample holders for making electrical contacts and Schottky junctions, all without breaking vacuum. We used this mechanism to transfer a barium strontium titanate thin film into the XPS analysis chamber and performed XPS measurements before and after exposing the sample to the air. After air exposure, a thin overlayer of carbon was found to form and a significant shift (~1 eV) in the core level binding energies was observed.

  16. The performance of a NERO 8000 non-invasive x-ray beam analyser when measuring tube voltage under fluoroscopic conditions.

    Science.gov (United States)

    Burrage, J W

    2001-09-01

    A NERO 8000 non-invasive x-ray beam analyser was examined under fluoroscopic conditions with respect to the measurement of tube voltage. An invasive measurement of tube voltage was performed concurrently to test the accuracy of the NERO device over a range of tube voltages and currents. The data indicated that for the NERO 8000 the accuracy of kVp average measurement is dependent on input doserate. With the tube current set to 1 mA the doserates ranged from 2.1 to 6.5 mGy/min over the range of tube voltages measured. The associated kVp average measurement errors ranged from 6 to 28%. At 5 mA the doserates ranged from 20.4 to 66.0 mGy/min and the associated errors ranged from 0 to 3%. A possible explanation for the drop in accuracy of kVp measurements at low doserates is a decreased signal to noise ratio. The kV waveforms from inaccurate measurements appeared noisier than waveforms from more accurate measurements. NERO may be interpreting noise spikes as voltage readings and including them in the kVp average calculations, causing an erroneously high kVp average reading. The data from this experiment suggest that when performing non-invasive measurements of tube voltage accuracy in fluoroscopy mode, the doserate must be taken into consideration.

  17. Design of an ultrahigh vacuum transfer mechanism to interconnect an oxide molecular beam epitaxy growth chamber and an x-ray photoemission spectroscopy analysis system

    Science.gov (United States)

    Rutkowski, M. M.; McNicholas, K. M.; Zeng, Zhaoquan; Brillson, L. J.

    2013-06-01

    We designed a mechanism and the accompanying sample holders to transfer between a VEECO 930 oxide molecular beam epitaxy (MBE) and a PHI Versa Probe X-ray photoemission spectroscopy (XPS) chamber within a multiple station growth, processing, and analysis system through ultrahigh vacuum (UHV). The mechanism consists of four parts: (1) a platen compatible with the MBE growth stage, (2) a platen compatible with the XPS analysis stage, (3) a sample coupon that is transferred between the two platens, and (4) the accompanying UHV transfer line. The mechanism offers a robust design that enables transfer back and forth between the growth chamber and the analysis chamber, and yet is flexible enough to allow transfer between standard sample holders for thin film growth and masked sample holders for making electrical contacts and Schottky junctions, all without breaking vacuum. We used this mechanism to transfer a barium strontium titanate thin film into the XPS analysis chamber and performed XPS measurements before and after exposing the sample to the air. After air exposure, a thin overlayer of carbon was found to form and a significant shift (˜1 eV) in the core level binding energies was observed.

  18. Method based on artificial excitation of characteristic radiation by an electron beam for remote X-ray spectral elemental analysis of surface rocks on atmosphereless celestial bodies

    Science.gov (United States)

    Kolesnikov, E. K.

    2016-11-01

    This article, like our previous one [1], is devoted to advanced space technology concepts. It evaluates the potential for developing active systems to conduct a remote elemental analysis of surface rocks on an atmosphereless celestial body. The analysis is based on the spectrometry of characteristic X-rays (CXR) artificially excited in the surface soil layer. It has been proposed to use an electron beam injected from aboard a spacecraft orbiting the celestial body (or moving in a flyby trajectory) to excite the CXR elements contained in surface rocks. The focus is on specifying technical requirements to the parameters of payloads for a global mapping of the composition of lunar rocks from aboard of a low-orbiting lunar satellite. This article uses the results obtained in [2], our first study that shows the potential to develop an active system for a remote elemental analysis of lunar surface rocks using the above method. Although there has been interest in our research on the part of leading national academic institutions and space technology developers in the Soviet Union, the studies were discontinued because of the termination of the Soviet lunar program and the completion of the American Apollo program.

  19. Design of an ultrahigh vacuum transfer mechanism to interconnect an oxide molecular beam epitaxy growth chamber and an x-ray photoemission spectroscopy analysis system

    Energy Technology Data Exchange (ETDEWEB)

    Rutkowski, M. M.; Zeng Zhaoquan [Department of Physics, Ohio State University, Columbus, Ohio 43210 (United States); McNicholas, K. M. [Department of Electrical and Computer Engineering, Ohio State University, Columbus, Ohio 43210 (United States); Brillson, L. J. [Department of Physics, Ohio State University, Columbus, Ohio 43210 (United States); Department of Electrical and Computer Engineering, Ohio State University, Columbus, Ohio 43210 (United States)

    2013-06-15

    We designed a mechanism and the accompanying sample holders to transfer between a VEECO 930 oxide molecular beam epitaxy (MBE) and a PHI Versa Probe X-ray photoemission spectroscopy (XPS) chamber within a multiple station growth, processing, and analysis system through ultrahigh vacuum (UHV). The mechanism consists of four parts: (1) a platen compatible with the MBE growth stage, (2) a platen compatible with the XPS analysis stage, (3) a sample coupon that is transferred between the two platens, and (4) the accompanying UHV transfer line. The mechanism offers a robust design that enables transfer back and forth between the growth chamber and the analysis chamber, and yet is flexible enough to allow transfer between standard sample holders for thin film growth and masked sample holders for making electrical contacts and Schottky junctions, all without breaking vacuum. We used this mechanism to transfer a barium strontium titanate thin film into the XPS analysis chamber and performed XPS measurements before and after exposing the sample to the air. After air exposure, a thin overlayer of carbon was found to form and a significant shift ({approx}1 eV) in the core level binding energies was observed.

  20. Particle-In-Cell Simulations of the Electron Beam Source for X-Ray Radiography Generated by the Rod-Pinch Diode in the Cygnus Experiment

    Science.gov (United States)

    Yin, Lin; Kwan, Thomas; Devolder, Barbara; Berninger, Mike; Bowers, Kevin; Smith, John

    2003-10-01

    The Cygnus experiment [Smith et al., AIP Conference Proceedings, 650, 135, 2002] is in operation at Los Alamos National Laboratory to support the Sub-Critical Experiments Program at the Nevada Test Site. In the Cygnus design, a rod-pinch diode is used to produce a low-energy (up to ˜ 2.25 MeV) radiographic electron source at the tip of a needle anode rod that extends through an annular cathode. As the electrons deposit their energies on the high-Z anode tip, bremsstrahlung photons are produced and are used to generate radiographs of an object. In this work we use the two-dimensional particle-in-cell code MERLIN to examine the diode physics and the dynamics of the rod-pinch electron source which is used in integrated X-ray radiographic chain model calculations [Kwan et al., Comp. Phys. Comm., 142, 263, 2001]. TEM waves are launched at one simulation boundary to set up the voltage required for the electron emission. Electron and ion trajectories are followed self-consistently in the electromagnetic fields as the electron beam impinges at the tip of the anode rod. The MERLIN simulation results of the electron endpoint energy and the diode voltage/current are consistent with the peak values obtained from Cygnus shots. The diode impedance response to the experimental parameters currently used in the Cygnus shots will be discussed.

  1. There ain't nothing like a Dame: a commentary on Lonsdale (1947) 'Divergent beam X-ray photography of crystals'.

    Science.gov (United States)

    Glazer, A M

    2015-04-13

    Prof. Dame Kathleen Lonsdale was one of the two first female Fellows of the Royal Society, having originally been a student of that great British scientist and Nobel Laureate William Henry Bragg. She came to fame initially for her solution of the crystal structure of hexamethyl benzene, thus demonstrating that the benzene ring was flat, of considerable importance to organic chemistry, where it had been proposed before but without proof. This was at a time when the solution of crystal structures was in its infancy, and in its day this work was considered a triumph. As a rare example then of a female physicist, Lonsdale became interested in various aspects of the diffraction of X-rays, and in particular published an important paper on a form of diffraction in which a strongly divergent source was used rather than the usual highly collimated beam. The photographs thus obtained showed a series of arcs and circles, whose positions were so sensitive that they could be used to determine the quality of crystals such as diamond, and even to calculate their lattice dimensions, and hence carbon-carbon bond lengths, to hitherto extraordinary precision. Lonsdale also became known not just as a scientist but as a peace activist and an active member of the Society of Friends. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.

  2. Characterisation of strip silicon detectors for the ATLAS Phase-II Upgrade with a micro-focused X-ray beam

    CERN Document Server

    INSPIRE-00407830; Blue, Andrew; Bates, Richard; Bloch, Ingo; Diez, Sergio; Fernandez-Tejero, Javier; Fleta, Celeste; Gallop, Bruce; Greenall, Ashley; Gregor, Ingrid-Maria; Hara, Kazuhiko; Ikegami, Yoichi; Lacasta, Carlos; Lohwasser, Kristin; Maneuski, Dzmitry; Nagorski, Sebastian; Pape, Ian; Phillips, Peter W.; Sperlich, Dennis; Sawhney, Kawal; Soldevila, Urmila; Ullan, Miguel; Unno, Yoshinobu; Warren, Matt

    2016-01-01

    The planned HL-LHC (High Luminosity LHC) in 2025 is being designed to maximise the physics potential through a sizable increase in the luminosity, totalling 1x10^35 cm^-2 s^-1 after 10 years of operation. A consequence of this increased luminosity is the expected radiation damage at 3000 fb^-1, requiring the tracking detectors to withstand hadron equivalences to over 1x10^16 1 MeV neutrons per cm^2. With the addition of increased readout rates, a complete re-design of the current ATLAS Inner Detector (ID) is being developed as the Inner Tracker (ITk). Two proposed detectors for the ATLAS strip tracker region of the ITk were characterized at the Diamond Light Source with a 3 micron FWHM 15 keV micro focused X-ray beam. The devices under test were a 320 micron thick silicon stereo (Barrel) ATLAS12 strip mini sensor wire bonded to a 130 nm CMOS binary readout chip (ABC130) and a 320 micron thick full size radial (Endcap) strip sensor - utilizing bi-metal readout layers - wire bonded to 250 nm CMOS binary readout...

  3. The measurement of stress and phase fraction distributions in pre and post-transition Zircaloy oxides using nano-beam synchrotron X-ray diffraction

    Science.gov (United States)

    Swan, H.; Blackmur, M. S.; Hyde, J. M.; Laferrere, A.; Ortner, S. R.; Styman, P. D.; Staines, C.; Gass, M.; Hulme, H.; Cole-Baker, A.; Frankel, P.

    2016-10-01

    Zircaloy-4 oxide stress profiles and tetragonal:monoclinic oxide phase fraction distributions were studied using nano-beam transmission X-ray diffraction. Continuous stress relief and phase transformation during the first cycle of oxide growth was observed. The in-plane monoclinic stress was shown to relax strongly up to each transition, whereas in-plane tetragonal stress-relief (near the metal-oxide interface) was only observed post transition. The research demonstrates that plasticity in the metal and the development of a band of in-plane cracking both relax the monoclinic in-plane stress. The observations are consistent with a model of transition in which in-plane cracking becomes interlinked prior to transition. These cracks, combined with the development of cracks with a through-thickness component (driven primarily by plasticity in the metal) and/or a porous network of fine cracks (associated with phase transformation), form a percolation path through the oxide layer. The oxidising species can then percolate from the oxide surface to the metal/oxide interface, at which stage transition then ensues.

  4. Direct observation of strain in InAs quantum dots and cap layer during molecular beam epitaxial growth using in situ X-ray diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Shimomura, Kenichi; Ohshita, Yoshio; Kamiya, Itaru, E-mail: kamiya@toyota-ti.ac.jp [Toyota Technological Institute, 2-12-1 Hisakata, Tempaku, Nagoya 468-8511 (Japan); Suzuki, Hidetoshi [Faculty of Engineering, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192 (Japan); Sasaki, Takuo; Takahasi, Masamitu [Quantum Beam Science Center, Japan Atomic Energy Agency, Koto 1-1-1, Sayo-cho, Hyogo 679-5148 (Japan)

    2015-11-14

    Direct measurements on the growth of InAs quantum dots (QDs) and various cap layers during molecular beam epitaxy are performed by in situ X-ray diffraction (XRD). The evolution of strain induced both in the QDs and cap layers during capping is discussed based on the XRD intensity transients obtained at various lattice constants. Transients with different features are observed from those obtained during InGaAs and GaAs capping. The difference observed is attributed to In-Ga intermixing between the QDs and the cap layer under limited supply of In. Photoluminescence (PL) wavelength can be tuned by controlling the intermixing, which affects both the strain induced in the QDs and the barrier heights. The PL wavelength also varies with the cap layer thickness. A large redshift occurs by reducing the cap thickness. The in situ XRD observation reveals that this is a result of reduced strain. We demonstrate how such information about strain can be applied for designing and preparing novel device structures.

  5. Modeling shift-variant X-ray focal spot blur for high-resolution flat-panel cone-beam CT

    CERN Document Server

    Tilley, Steven; Siewerdsen, Jeffrey H; Stayman, J Webster

    2016-01-01

    Flat-panel cone-beam CT (CBCT) has been applied clinically in a number of high-resolution applications. Increasing geometric magnification can potentially improve resolution, but also increases blur due to an extended x-ray focal-spot. We present a shift-variant focal-spot blur model and incorporate it into a model-based iterative-reconstruction algorithm. We apply this algorithm to simulation and CBCT test-bench data. In a trabecular bone simulation study, we find traditional reconstruction approaches without a blur model exhibit shift-variant resolution properties that depend greatly on the acquisition protocol (e.g. short vs. full scans) and the anode angles of the rays used to reconstruct a particular region. For physical CBCT experiments focal spot blur was characterized and a spatial resolution phantom was scanned and reconstructed. In both experiments image quality using the shift-variant model was significantly improved over approaches that modeled no blur or only a shift-invariant blur, suggesting a ...

  6. Elliptical X-Ray Spot Measurement

    CERN Document Server

    Richardson, R A; Weir, J T; Richardson, Roger A.; Sampayan, Stephen; Weir, John T.

    2000-01-01

    The so-called roll bar measurement uses a heavy metal material, optically thick to x-rays, to form a shadow of the x-ray origination spot. This spot is where an energetic electron beam interacts with a high Z target. The material (the "roll bar") is slightly curved to avoid alignment problems. The roll bar is constructed and positioned so that the x-rays are shadowed in the horizontal and vertical directions, so information is obtained in two dimensions. If a beam profile is assumed (or measured by other means), the equivalent x-ray spot size can be calculated from the x-ray shadow cast by the roll bar. Thus the ellipticity of the beam can be calculated, assuming the ellipse of the x-ray spot is aligned with the roll bar. The data is recorded using a scintillator and gated camera. Data will be presented from measurements using the ETA II induction LINAC. The accuracy of the measurement is checked using small elliptical targets.

  7. 上海光源光束线前端区 XBPM 探测器%The X-ray Beam Position Monitor Used in the Front end of SSRF

    Institute of Scientific and Technical Information of China (English)

    龚培荣; 徐慧超; 周剑英; 何迎花; 张永立; 朱周侠; 蒋建国

    2015-01-01

    XBPM探测器是同步辐射装置中测量X光位置的关键设备,主要用于测量光源点产生的X光的位置和光斑形状等。本文着重阐述了用于上海光源光束线前端区的刀片式X光位置探测器的构成及其分析,荧光靶探测器的结构,以及如何使用两种探测器在Canted光束线上进行初次调光;同时,就这两种探测器的当前现状和今后的发展做了简要的说明,并给出了上海光源一期光束线前端区XBPM探测器升级改造的初步结果。%The XBPM ( X ray Beam Position Monitor) detector is the key device of the beamline for measuring x ray beam position or observing x ray spot shape.Each synchrotron light source must manufacture and own itself XBPM detector.In order to measure x ray beam position accurately and display it for users, and to give a feed-back signal for stabilizing output x ray beam.The blade XBPM detector ( BBPM) and Fluorescence screen de-tector ( FS) were usually adopted at front end of the beamline.The FS is very useful to adjust light path roughly during commissioning and the BBPM signal can lead to adjustment finely.The structure and the constituent a-nalysis of the BBPM and the FS were introduced at first, and main talk was about how to use these two types of XBPM to adjust x ray beam path in the first debugging for the Canted beamline commissioning.Meanwhile, the currently status and future development about these two types of XBPM were mentioned, and a brief description of the upgrading outcome about the BBPM used in the front end of the beamline of SSRF were given.Now the white x-ray measurement resolution of the XBPM detector was 1 micron in vertical direction and 2 microns in horizontal direction at SSRF.

  8. X线钼靶摄影与超声诊断乳腺微钙化灶的对比研究%Comparative Study of X-ray Mammography Photography and Ultrasound Diagnostic in Breast Microcalcifications

    Institute of Scientific and Technical Information of China (English)

    张敏丽; 刘东顺; 贾七英; 魏志强

    2015-01-01

    Objective:To explore the effect of X-ray mammography photography and ultrasonic diagnosis in breast microcalcifications. Method:120 cases with breast microcalcifications from February 2012 to February 2015 were selected,they were given X-ray mammography photography and ultrasonic diagnosis.The two methods of sensitivity, specificity and accuracy were compared.Result:X-ray mammography photographic and ultrasound combined use of the accuracy,specificity and sensitivity were higher than X-ray mammography and ultrasound diagnosis of photography, the difference was significant(P<0.05).The sensitivity of X-ray mammography photographic was significantly higher than that of ultrasound diagnosis,and the specificity of ultrasonic diagnostic was higher than X-ray mammography photography,the difference was significant(P<0.05).Conclusion:X-ray mammography photography has high sensitivity for the diagnosis of breast microcalcifications,and the ultrasonic diagnosis has high specificity,a combination of both can significantly improve the diagnostic accuracy rate,is worthy of clinical promotion.%目的:探究采用X线钼靶摄影和超声诊断乳腺微钙化灶的诊断效果.方法:选择笔者所在医院2012年2月-2015年2月收治的120例乳腺微钙化灶患者,均给予患者X线钼靶摄影和超声诊断.对比两种方法敏感性、特异性和准确性情况.结果:X线钼靶摄影和超声联合应用的准确性、特异性和敏感性均高于X线钼靶摄影和超声诊断,差异有统计学意义(P<0.05).X线钼靶摄影的敏感性显著高于超声诊断,而超声诊断的特异性高于X线钼靶摄影,差异有统计学意义(P<0.05).结论:对于乳腺钙化灶的诊断采用X线钼靶摄影具有较高的敏感性,而采用超声诊断具有较高的特异性,两者联合使用能够显著提高诊断准确率,值得临床推广.

  9. Breast tomosynthesis with monochromatic beams: a feasibility study using Monte Carlo simulations

    Science.gov (United States)

    Malliori, A.; Bliznakova, K.; Sechopoulos, I.; Kamarianakis, Z.; Fei, B.; Pallikarakis, N.

    2014-08-01

    The aim of this study is to investigate the impact on image quality of using monochromatic beams for lower dose breast tomosynthesis (BT). For this purpose, modeling and simulation of BT and mammography imaging processes have been performed using two x-ray beams: one at 28 kVp and a monochromatic one at 19 keV at different entrance surface air kerma ranging between 0.16 and 5.5 mGy. Two 4 cm thick computational breast models, in a compressed state, were used: one simple homogeneous and one heterogeneous based on CT breast images, with compositions of 50% glandular-50% adipose and 40% glandular-60% adipose tissues by weight, respectively. Modeled lesions, representing masses and calcifications, were inserted within these breast phantoms. X-ray transport in the breast models was simulated with previously developed and validated Monte Carlo application. Results showed that, for the same incident photon fluence, the use of the monochromatic beam in BT resulted in higher image quality compared to the one using polychromatic acquisition, especially in terms of contrast. For the homogenous phantom, the improvement ranged between 15% and 22% for calcifications and masses, respectively, while for the heterogeneous one this improvement was in the order of 33% for the masses and 17% for the calcifications. For different exposures, comparable image quality in terms of signal-difference-to-noise ratio and higher contrast for all features was obtained when using a monochromatic 19 keV beam at a lower mean glandular dose, compared to the polychromatic one. Monochromatic images also provide better detail and, in combination with BT, can lead to substantial improvement in visualization of features, and particularly better edge detection of low-contrast masses.

  10. X-ray Pulsars

    CERN Document Server

    Walter, Roland

    2016-01-01

    X-ray pulsars shine thanks to the conversion of the gravitational energy of accreted material to X-ray radiation. The accretion rate is modulated by geometrical and hydrodynamical effects in the stellar wind of the pulsar companions and/or by instabilities in accretion discs. Wind driven flows are highly unstable close to neutron stars and responsible for X-ray variability by factors $10^3$ on time scale of hours. Disk driven flows feature slower state transitions and quasi periodic oscillations related to orbital motion and precession or resonance. On shorter time scales, and closer to the surface of the neutron star, X-ray variability is dominated by the interactions of the accreting flow with the spinning magnetosphere. When the pulsar magnetic field is large, the flow is confined in a relatively narrow accretion column, whose geometrical properties drive the observed X-ray emission. In low magnetized systems, an increasing accretion rate allows the ignition of powerful explosive thermonuclear burning at t...

  11. X线、MRI对乳腺癌的综合诊断价值%Clinical Application Value of X-ray and MRI in the Diagnosis of Breast Carcinoma

    Institute of Scientific and Technical Information of China (English)

    郭永榜

    2015-01-01

    目的:探讨X线、MRI对乳腺癌的综合诊断价值。方法回顾性分析本院36例经病理证实的乳腺癌患者X线和MRI表现,从病灶形态学、钙化、淋巴结、皮肤及胸壁受累情况及信号特点、强化模式等方面进行分析诊断,比较两种方法在检出率、诊断准确率、病灶范围等方面的价值。结果X线检出病灶30个,检出率为83.3%,诊断确诊率为80.6%,MRI检出病灶36个,检出率为100.0%,诊断准确率为91.7%。结论乳腺X线摄影检查直观、有效,是诊断乳腺癌的首选检查方法,结合MRI可提高诊断的灵敏度和特异度。%Objective To explore the comprehensive value of X-ray mammography and MRI in diagnosing the breast cancer.Methods 36 cases of patients with breast cancer were enrol ed,both mammography and MRI scan were performed,including tumor morphology,calcification,signal characteristics, enhanced mode and Si-time curve,the values of X-ray and MRl were evaluated.Results 30 masses were found by X-ray mammogram,detection rate was 83.3%and accuracy rate of X-ray was 80.6%,36 masses were detected by MRI,detection rate was 100.0%and accuracy rate of MRl was 91.7%.Conclusion A direct and effective means to breast cancer should be based on X-ray,the molybdenum X-ray mammography is helpful in the diagnosis of breast cancer,the sensitivity and specificity combined with MRI are enhanced when compared to that of single modality.

  12. The Value of X-ray Mammography in Differential Diagnosis of Breast Phyllodes Tumors and Fibroadenoma%钼靶X线在乳腺叶状肿瘤和纤维腺瘤鉴别诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    杨礼睿; 陈霞

    2014-01-01

    目的:分析乳腺叶状肿瘤和纤维腺瘤的钼靶X线摄影的表现,归纳总结其钼靶X线影像特征,提高乳腺叶状肿瘤的诊断准确率。方法回顾性分析经病理证实的27例叶状肿瘤钼靶X线影像表现,并以病理证实的28例纤维腺瘤为对照。结果钼靶X线表现肿块周边有"晕"征,在叶状肿瘤与纤维腺瘤中比较差异有统计学意义(P<0.05)。结论肿块周边有"晕"征在乳腺叶状肿瘤和纤维腺瘤鉴别诊断中有诊断意义。%Objectives: To analyze the X-ray mammography breast phyl ode tumor and breast fibroadenoma of the performance,to sum up the molybdenum target X-ray imaging features,to improve the accuracy of diagnosis of phyl odes tumors of the breast. Methods A retrospective analysis was made of 27 cases of phyl odes tumor of molybdenum target X-ray manifestations and pathology,and 28 cases of fibroadenoma confirmed by pathology were. Results The mammographic features in addition to mass surrounding a "halo" syndrome in phyl odes tumor and breast fibroadenoma,the dif erence was statistical y significant (P<0.05). Conclusion Mass surrounding a "halo"sign is of diagnostic significance in dif erential diagnosis of breast phyl ode tumor and breast fibroadenoma.

  13. Measure of the attenuation curve of a beam of X-rays with TLD-100 dosimeters of LiF; Medicion de la curva de atenuacion de un haz de rayos X con dosimetros TLD-100 de LiF

    Energy Technology Data Exchange (ETDEWEB)

    Bonzi, E. V.; Mainardi, R. T. [Universidad Nacional de Cordoba, Facultad de Matematica, Astronomia y Fisica, Av. Haya de la Torre y Av. Medina Allende s/n, Ciudad Universitaria, Cordoba (Argentina); Germanier, A. [Ministerio de Ciencia y Tecnologia, Ceprocor, Unidad de Estudios Fisicos, Alvarez de Arenas 230, X5004AAP Barrio Juniors, Cordoba (Argentina); Delgado, V. [Universidad Complutense de Madrid, Departamento de Fisica Medica, Ciudad Universitaria, 28040 Madrid (Spain)

    2011-10-15

    The attenuation curve of a beam of X-rays represents the beam intensity in function of the attenuator thickness interposed between the source and the detector. To know with the major possible precision the attenuation curve is indispensable in procedures of spectral reconstruction. Their periodic measuring also offers valuable information on the correct operation of a tube of X-rays, diagnostic or therapy, when not have a specific detector for that activity. In this work was measured the attenuation curve of a tube of X-rays operated to 50 kV and 0.5 ma, using existent elements in any diagnostic or therapy laboratory with radiations. In the measures commercial aluminum foil was used, bent until 24 times and thermoluminescent dosimeters TLD 100 - LiF. Also, for comparison, was measured this attenuation curve with an ionization chamber brand Capintec model 192. Was determined by X-rays fluorescence the composition of the aluminium foil, since the present elements in the alloy can to affect the form of the attenuation curve. It is interesting to observe that these elements are in very low proportion (ppm) that they do not alter the attenuation capacity of the pure aluminium. Finally in a precision balance we weigh a big piece (30 cm x 100 cm) of aluminium foil and we obtained the thickness in g/c m2. It is possible to obtain attenuation curves of a beam of X-rays, with a high precision procedure and reproducibility. The use of TLD-100 dosimeters of LiF or similar makes that this activity was also quick and simple. (Author)

  14. X-Ray Protection

    Science.gov (United States)

    1955-01-01

    15,000. • When developed In Kodak liquid X-ray developer for 5 min at a temperature of 200 C. b Film sensitivities vary with photon energy by the...for example temporomandibular -joint exposures where a skin dose of 25 r or more may be obtained during a single exposure with 65 kvp, 1.5 mm aluminum...communication. W. J. Updegrave, Temporomandibular articulation-X-ray examina- tion, Dental Radiography and Photography 26, No. 3, 41 (1953). H. 0. Wyckoff, R. J

  15. On the Use of Wide-Angle Energy-Sensitive Detectors in White-Beam X-Ray Single-Crystal Diffraction

    DEFF Research Database (Denmark)

    Buras, B.; Staun Olsen, J.; Gerward, Leif

    1980-01-01

    The possible applications of multiple-element or large-area semiconductor detectors in single-crystal X-ray diffraction are discussed on the basis of experimental results using Bremsstrahlung as well as synchrotron radiation.......The possible applications of multiple-element or large-area semiconductor detectors in single-crystal X-ray diffraction are discussed on the basis of experimental results using Bremsstrahlung as well as synchrotron radiation....

  16. A Monte Carlo study of x-ray fluorescence in x-ray detectors.

    Science.gov (United States)

    Boone, J M; Seibert, J A; Sabol, J M; Tecotzky, M

    1999-06-01

    Advances in digital x-ray detector systems have led to a renewed interest in the performance of x-ray phosphors and other detector materials. Indirect flat panel x-ray detector and charged coupled device (CCD) systems require a more technologically challenging geometry, whereby the x-ray beam is incident on the front side of the scintillator, and the light produced must diffuse to the back surface of the screen to reach the photoreceptor. Direct detector systems based on selenium have also enjoyed a growing interest, both commercially and academically. Monte Carlo simulation techniques were used to study the x-ray scattering (Rayleigh and Compton) and the more prevalent x-ray fluorescence properties of seven different x-ray detector materials, Gd2O2S, CsI, Se, BaFBr, YTaO4, CaWO4, and ThO2. The redistribution of x-ray energy, back towards the x-ray source, in a forward direction through the detector, and lateral reabsorption in the detector was computed under monoenergetic conditions (1 keV to 130 keV by 1 keV intervals) with five detector thicknesses, 30, 60, 90, 120, and 150 mg/cm2 (Se was studied from 30 to 1000 mg/cm2). The radial distribution (related to the point spread function) of reabsorbed x-ray energy was also determined. Representative results are as follows: At 55 keV, more (31.3%) of the incident x-ray energy escaped from a 90 mg/cm2Gd2O2S detector than was absorbed (27.9%). Approximately 1% of the total absorbed energy was reabsorbed greater than 0.5 mm from the primary interaction, for 90 mg/cm2 CsI exposed at 100 kVp. The ratio of reabsorbed secondary (fluorescence + scatter) radiation to the primary radiation absorbed in the detectors (90 mg/cm2) (S/P) was determined as 10%, 16%, 2%, 12%, 3%, 3%, and 0.3% for a 100 kVp tungsten anode x-ray spectrum, for the Gd2O2S, CsI, Se, BaFBr, YTaO4, CaWO4, and ThO2 detectors, respectively. The results indicate significant x-ray fluorescent escape and reabsorption in common x-ray detectors. These findings

  17. Microfabrication of hard x-ray lenses

    DEFF Research Database (Denmark)

    Stöhr, Frederik

    in the vertical and horizontal directions was addressed. A functioning prototype of a 2D silicon objective for use in a bright-field hard-XRM was demonstrated. The results are promising; showing acceptably low aberration and performance close to theoretical expectations. A resolution of 300 nm with 17 keV x......This thesis deals with the development of silicon compound refractive lenses (Si-CRLs) for shaping hard x-ray beams. The CRLs are to be fabricated using state of the art microfabrication techniques. The primary goal of the thesis work is to produce Si-CRLs with considerably increased structure...... intense and wider line beams with narrower waists. The thesis starts with a review of alternative x-ray lenses. Si-CRLs are identified as valuable optical components that allow shaping hard x-rays efficiently and creating beam waists that are clearly in the nanometer range. They stand out...

  18. High spectral and spatial resolution X-ray transmission radiography and tomography using a Color X-ray Camera

    OpenAIRE

    Boone, Matthieu; Garrevoet, Jan; Tack, Pieter; Scharf, Oliver; Cormode, David P.; Van Loo, Denis; Pauwels, Elin; Dierick, Manuel; Vincze, Laszlo; Van Hoorebeke, Luc

    2013-01-01

    High resolution X-ray radiography and computed tomography are excellent techniques for non-destructive characterization of an object under investigation at a spatial resolution in the micrometer range. However, as the image contrast depends on both chemical composition and material density, no chemical information is obtained from this data. Furthermore, lab-based measurements are affected by the polychromatic X-ray beam, which results in beam hardening effects. New types of X-ray detectors w...

  19. 数字钼靶X线摄影结合触诊在乳腺病变诊断中的价值%Diagnostic value of digital mammography X-ray and palpation in breast lesions

    Institute of Scientific and Technical Information of China (English)

    彭晓澜; 郑青霞

    2011-01-01

    Objective To discuss the diagnostic value of mammography X-ray and palpation in benign and malignant lesions of breast. Methods One hundred and twelve breast lesions comfirmed by operations and pathological diagnosis during June 2008 to 2010 were collected, and the mammography X-ray performance in benign and malignant lesions of breast were retropectly analyed. Results The mammography X-ray performance could be taken as a reference to the qualitative diagnosis of benign and malignant lesions. Palpation was simple and had more intuitive and comprehensive understanding for patients. Conclusion Mammography X-ray performance and palpating in benign and malignant lesions qualitative diagnosis plays a complementary roles.%目的 探讨数字钼靶X线摄影结合触诊在乳腺病变的定性诊断价值.方法 收集2008-2010-06经手术和病理证实的112个乳腺病变资料,对钼靶X线诊断及触诊检查的良恶性病变进行回顾性分析.结果 钼靶X线表现可作为乳腺病变良恶性定性诊断的有效的检查手段,触诊检查简单易行,对患者有一个更直观和全面的认识.结论 钼靶X线表现及触诊在良恶性病变的定性诊断中起着互补的作用.

  20. Evaluating the Effect of Processing Parameters on Porosity in Electron Beam Melted Ti-6Al-4V via Synchrotron X-ray Microtomography

    Science.gov (United States)

    Cunningham, Ross; Narra, Sneha P.; Ozturk, Tugce; Beuth, Jack; Rollett, A. D.

    2016-03-01

    Electron beam melting (EBM) is one of the subsets of direct metal additive manufacturing (AM), an emerging manufacturing method that fabricates metallic parts directly from a three-dimensional (3D) computer model by the successive melting of powder layers. This family of technologies has seen significant growth in recent years due to its potential to manufacture complex components with shorter lead times, reduced material waste and minimal post-processing as a "near-net-shape" process, making it of particular interest to the biomedical and aerospace industries. The popular titanium alloy Ti-6Al-4V has been the focus of multiple studies due to its importance to these two industries, which can be attributed to its high strength to weight ratio and corrosion resistance. While previous research has found that most tensile properties of EBM Ti-6Al-4V meet or exceed conventional manufacturing standards, fatigue properties have been consistently inferior due to a significant presence of porosity. Studies have shown that adjusting processing parameters can reduce overall porosity; however, they frequently utilize methods that give insufficient information to properly characterize the porosity (e.g., Archimedes' method). A more detailed examination of the result of process parameter adjustments on the size and spatial distribution of gas porosity was performed utilizing synchrotron-based x-ray microtomography with a minimum feature resolution of 1.5 µm. Cross-sectional melt pool area was varied systematically via process mapping. Increasing melt pool area through the speed function variable was observed to significantly reduce porosity in the part.

  1. Characterisation of strip silicon detectors for the ATLAS Phase-II Upgrade with a micro-focused X-ray beam

    Science.gov (United States)

    Poley, L.; Blue, A.; Bates, R.; Bloch, I.; Díez, S.; Fernandez-Tejero, J.; Fleta, C.; Gallop, B.; Greenall, A.; Gregor, I.-M.; Hara, K.; Ikegami, Y.; Lacasta, C.; Lohwasser, K.; Maneuski, D.; Nagorski, S.; Pape, I.; Phillips, P. W.; Sperlich, D.; Sawhney, K.; Soldevila, U.; Ullan, M.; Unno, Y.; Warren, M.

    2016-07-01

    The planned HL-LHC (High Luminosity LHC) in 2025 is being designed to maximise the physics potential through a sizable increase in the luminosity up to 6·1034 cm-2s-1. A consequence of this increased luminosity is the expected radiation damage at 3000 fb-1 after ten years of operation, requiring the tracking detectors to withstand fluences to over 1·1016 1 MeV neq/cm2. In order to cope with the consequent increased readout rates, a complete re-design of the current ATLAS Inner Detector (ID) is being developed as the Inner Tracker (ITk). Two proposed detectors for the ATLAS strip tracker region of the ITk were characterized at the Diamond Light Source with a 3 μm FWHM 15 keV micro focused X-ray beam. The devices under test were a 320 μm thick silicon stereo (Barrel) ATLAS12 strip mini sensor wire bonded to a 130 nm CMOS binary readout chip (ABC130) and a 320 μm thick full size radial (end-cap) strip sensor - utilizing bi-metal readout layers - wire bonded to 250 nm CMOS binary readout chips (ABCN-25). A resolution better than the inter strip pitch of the 74.5 μm strips was achieved for both detectors. The effect of the p-stop diffusion layers between strips was investigated in detail for the wire bond pad regions. Inter strip charge collection measurements indicate that the effective width of the strip on the silicon sensors is determined by p-stop regions between the strips rather than the strip pitch.

  2. Characterisation of silicon microstrip detectors for the ATLAS Phase-II Upgrade with a micro-focused X-ray beam

    Energy Technology Data Exchange (ETDEWEB)

    Poley, Luise [DESY, Hamburg (Germany); Blue, Andrew; Bates, Richard [Glasgow Univ. (United Kingdom). SUPA School of Physics and Astronomy; and others

    2016-03-15

    The planned HL-LHC (High Luminosity LHC) in 2025 is being designed to maximise the physics potential through a sizable increase in the luminosity, totalling 1 x 10{sup 35} cm{sup -2}s{sup -1} after 10 years of operation. A consequence of this increased luminosity is the expected radiation damage at 3000 fb{sup -1}, requiring the tracking detectors to withstand hadron equivalences to over 1 x 10{sup 16} 1 MeV neutrons per cm{sup 2}. With the addition of increased readout rates, a complete re-design of the current ATLAS Inner Detector (ID) is being developed as the Inner Tracker (ITk). Two proposed detectors for the ATLAS strip tracker region of the ITk were characterized at the Diamond Light Source with a 3 μm FWHM 15 keV micro focused X-ray beam. The devices under test were a 320 μm thick silicon stereo (Barrel) ATLAS12 strip mini sensor wire bonded to a 130 nm CMOS binary readout chip (ABC130) and a 320 μm thick full size radial (Endcap) strip sensor - utilizing bi-metal readout layers - wire bonded to 250 nm CMOS binary readout chips (ABCN-25). Sub-strip resolution of the 74.5 μm strips was achieved for both detectors. Investigation of the p-stop diffusion layers between strips is shown in detail for the wire bond pad regions. Inter strip charge collection measurements indicate that the effective width of the strip on the silicon sensors is determined by p-stops regions between the strips rather than the strip pitch. The collected signal allowed for the identification of operating thresholds for both devices, making it possible to compare signal response between different versions of silicon strip detector modules.

  3. Scanning X-ray nanodiffraction: from the experimental approach towards spatially resolved scattering simulations

    OpenAIRE

    Dubslaff, Martin; Hanke, Michael; Patommel, Jens; Hoppe, Robert; Schroer, Christian G.; Schöder, Sebastian; Burghammer, Manfred

    2012-01-01

    An enhancement on the method of X-ray diffraction simulations for applications using nanofocused hard X-ray beams is presented. We combine finite element method, kinematical scattering calculations, and a spot profile of the X-ray beam to simulate the diffraction of definite parts of semiconductor nanostructures. The spot profile could be acquired experimentally by X-ray ptychography. Simulation results are discussed and compared with corresponding X-ray nanodiffraction experiments on single ...

  4. Simulations of X-ray spectrum and HVL for mammographic equipment using MCNP5 code

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Rafael Toledo F. de; Alvarez, Matheus; Velo, Alexandre F.; Oliveira, Marcela de; Miranda, Jose Ricardo A. [Universidade Estadual Paulista Julio de mesquita Filho (UNESP), Botucatu, SP (Brazil). Inst. de Biociencias de Botucatu. Dept. de Fisica e Biofisica; Pina, Diana R. [Universidade Estadual Paulista Julio de mesquita Filho (UNESP), Botucatu, SP (Brazil). Fac. de Medicina. Dept. de Doencas Tropicais e Diagnostico por Imagem

    2012-07-01

    Full text: The main goal of mammography is early detection of breast cancer. Thus, the mammograph should be designed so that the X-ray photons are emitted within an appropriate energy range, to distinguish the normal breast tissue and cancerous tissue. The distribution of the photons amount of X-ray beam, with their respective energies, is called the spectrum. From the spectrum it is possible to estimate the quality of the X-ray beam from the Half Value Layer (HVL). Objectives: This study aims to simulate the Senographe 600T mammography unit, manufactured by General Electric (GE), using the MCNP5 Monte Carlo code, to obtain its spectrum and HVL, and compare the HVL of the simulated model with experimental data. Method: the mammography unit was simulated using a simplified model which a beam of 2x10{sup 8} electrons focuses on a Mo target angled 12 degrees, within a capsule filled with vacuum. The incident electrons were converted into photons. The capsule has a beryllium window, allowing the passage of the X-ray beam. The beam is detected by an air cylinder with 1 cm thickness placed 60 cm from the target. On the path of X-ray beam, is inserted a 0.03 mm Mo filter located 1.6 cm after the beryllium window. The space between the capsule and the detector cylinder was filled with air. The quality of X-ray beam was verified from the HVL using the MCNP5 code and the experimental method for the voltage range typically used in clinical routine (26-31 kVp). Results and discussion: the X-ray spectrum of the mammography device is satisfactorily simulated by MCNP5, showing the characteristic radiation peaks of molybdenum at 17.479 keV and 19.602 keV, the filtered spectrum generated by Bremsstrahlung, and reducing the total number of photons with the decrease in applied tension (kVp). The HVL obtained by MCNP5 and experimental measurements show a maximum difference of 5.31% (for 31 kVp). The result of both methods are within acceptable limits established by national

  5. Application of digital mammography X-ray photography in clinical diagnosis of breast tumor%数字化钼靶 X线摄影在乳腺肿瘤临床诊断中的应用

    Institute of Scientific and Technical Information of China (English)

    徐艳红

    2014-01-01

    目前乳腺癌已居我国女性恶性肿瘤首位,早期发现、早期诊断和早期治疗是改善乳腺癌患者预后的重要手段,而数字化钼靶X线摄影被公认为是乳腺癌影像检查的首选方法。该文旨在通过研究乳腺癌的发病趋势及早期诊断的重要性,进而讨论数字化乳腺钼靶X线摄影在乳腺癌诊断中的优势、X线影像表现、临床应用效果、钼靶X线诊断的仪器与检查方法、分类及研究进展,以提高其在乳腺肿瘤临床早期诊断中的价值。%Breast cancer has become the leading female malignancy in China; therefore , early detection , diagnosis and treatment are important means to improve the prognosis of breast cancer .Digital mammography X-ray photography is considered as the preferred method for imaging inspection of breast cancer .The paper aims to discuss the trend of breast cancer incidence and importance of early diagnosis of the disease , and improve the value of digital mammography X-ray in early clinical diagnosis of breast cancer by exploring the superiority of the technique , X-ray imaging manifestations , imaging findings , clinical application results , molybdenum target apparatus and inspection methods , classification and research progress .

  6. An analysis of mammography X-ray signs in patients with breast fibroadenomas%乳腺纤维腺瘤乳腺钼靶X射线征象分析

    Institute of Scientific and Technical Information of China (English)

    邵婉仪; 葛宇曦; 邵琳; 李晓红; 王子; 陆黎; 延根

    2016-01-01

    Objective To analyze the characteristics of mammography X-ray signs in the patients with breast fibroadenomas.Methods Mammography X-ray images of 200 patients with breast fibroadenomas were retrosepctively analyzed with imaging reporting and data system.Results Breast fibroadenomas occured in 152 cases(76 %) with compacted type and large glandular type of the breast.Breast fibroadenomas located in the upper outer quadrant in 116 cases (58%).Breast fibroadenomas displayed as lump or lump with calcification in 148 cases (74%),pure calcification in 17 cases,asymmetrical dense glandular in 26 cases,and no abnormal findings in 9 cases on mammography X-ray images.Conclusion In the analysis of mammography X-ray signs in the patients with breast fibroadenomas,attention should be paid to evaluating the calcification and asymmetrical dense glandular signs.%目的 分析乳腺纤维腺瘤乳腺钼靶X射线征象特征.方法 回顾性分析200例乳腺纤维腺瘤患者的乳腺钼靶X射线图,采用乳腺影像报告和数据系统4级分析X射线征象.结果 乳腺纤维腺瘤发生于致密型和多量腺体型乳腺者152例(76%);发病部位位于外上象限者116例(58%).以肿块或肿块合并钙化出现者148例(74%),单纯钙化17例,不对称致密腺体26例,9例未见乳腺钼靶X射线异常表现.结论 分析乳腺纤维腺瘤钼靶X射线征象时,也应重视单纯钙化和不对称致密腺体的X射线征象.

  7. Application value of molybdenum target X-ray examination in diagnosis of breast cancer%钼靶X线检查在乳腺癌诊断中的应用价值

    Institute of Scientific and Technical Information of China (English)

    王悦

    2015-01-01

    目的:探讨乳腺癌诊断中应用钼靶X线检查的价值,提高乳腺癌的早期诊断率。方法回顾性分析经手术病理确诊的66例乳腺癌患者的临床及钼靶X线检查影像资料。结果66例乳腺癌患者钼靶X线片大部分有较敏感的显影及直接征象和间接征象,均行乳腺癌根治术或改良根治术,钼靶诊断与术后病理诊断符合率为100%。结论钼靶X线检查可以大大提高乳腺癌的诊断准确率,对乳腺癌的早期明确诊断具有重要的意义,可作为早期乳腺癌诊断的首选方法。%Objective To explore the application value of molybdenum target X-ray examination in diagnosis of breast cancer, so as to improve the early diagnosis rate of breast cancer.Methods The clinical and molybdenum target X-ray examination imaging data of 66 breast cancer patients were retrospectively analyzed. Results There were sensitive and direct and indirect signs in most of the molybdenum target X-ray imaging in 66 breast cancer cases. All the cases received radical mastectomy or improved mastectomy. The coincidence rate of molybdenum target diagnosis and postoperative pathological diagnosis was 100%.Conclusion Molybdenum target X-ray examination can remarkably improve the accuracy rate of breast cancer diagnosis, and it has important value for early diagnosis of breast cancer. This method can be use as the primary method in early diagnosis of breast cancer.

  8. Tenth value layers for 60Co gamma rays and for 4, 6, 10, 15, and 18 MV x rays in concrete for beams of cone angles between 0 degrees and 14 degrees calculated by Monte Carlo simulation.

    Science.gov (United States)

    Jaradat, Adnan K; Biggs, Peter J

    2007-05-01

    The calculation of shielding barrier thicknesses for radiation therapy facilities according to the NCRP formalism is based on the use of broad beams (that is, the maximum possible field sizes). However, in practice, treatment fields used in radiation therapy are, on average, less than half the maximum size. Indeed, many contemporary treatment techniques call for reduced field sizes to reduce co-morbidity and the risk of second cancers. Therefore, published tenth value layers (TVLs) for shielding materials do not apply to these very small fields. There is, hence, a need to determine the TVLs for various beam modalities as a function of field size. The attenuation of (60)Co gamma rays and photons of 4, 6, 10, 15, and 18 MV bremsstrahlung x ray beams by concrete has been studied using the Monte Carlo technique (MCNP version 4C2) for beams of half-opening angles of 0 degrees , 3 degrees , 6 degrees , 9 degrees , 12 degrees , and 14 degrees . The distance between the x-ray source and the distal surface of the shielding wall was fixed at 600 cm, a distance that is typical for modern radiation therapy rooms. The maximum concrete thickness varied between 76.5 cm and 151.5 cm for (60)Co and 18 MV x rays, respectively. Detectors were placed at 630 cm, 700 cm, and 800 cm from the source. TVLs have been determined down to the third TVL. Energy spectra for 4, 6, 10, 15, and 18 MV x rays for 10 x 10 cm(2) and 40 x 40 cm(2) field sizes were used to generate depth dose curves in water that were compared with experimentally measured values.

  9. In situ investigation of the surface silvering of late Roman coins by combined use of high energy broad-beam and low energy micro-beam X-ray fluorescence techniques

    Energy Technology Data Exchange (ETDEWEB)

    Romano, F.P., E-mail: romanop@lns.infn.it [IBAM, CNR, Via Biblioteca 4, 95124 Catania (Italy); LNS, INFN, Via S. Sofia 62, 95123 Catania (Italy); Garraffo, S. [ITABC, CNR, Via Salaria km 29.300, 00016 Monterotondo, Roma (Italy); Pappalardo, L. [IBAM, CNR, Via Biblioteca 4, 95124 Catania (Italy); LNS, INFN, Via S. Sofia 62, 95123 Catania (Italy); Rizzo, F. [LNS, INFN, Via S. Sofia 62, 95123 Catania (Italy); Dipartimento di Fisica e Astronomia, Universita di Catania, Via S. Sofia 64, 95123 Catania (Italy)

    2012-07-15

    The compositional analysis of archeological metals performed with the X-ray Fluorescence technique (XRF) provides information on the ancient technology. One of the most interesting case-study concerns the techniques used by Romans for silvering the surface of coins. Different metallurgical processes have been suggested in previous studies. Recently the investigation has been addressed to the mercury-silvering and to its possible use in the mass-production of coins minted during the late period (after 294 AD). In the present paper the non-destructive investigation of the silvering process used for manufacturing the Roman nummi - the important typology of coin introduced by Diocletian in his monetary reform - is approached by the combined use of the standard X-Ray Fluorescence (XRF) and the low energy micro-X-Ray Fluorescence (LE-{mu}XRF) portable methods. The research was focused on the systematic determination of the mercury presence in a large number of samples and on its correlation with silver in the surface of the coins. 1041 Roman nummi belonging to the Misurata Treasure were analyzed in situ, at the Leptis Magna Museum (Al Khums, Libya). The treasure, composed of about 108 thousand silvered coins, gives the unique opportunity to study the Roman coinage in a wide interval of time (about 40 years in the period 294-333 AD) and in almost all the imperial mints operating in the Roman world. - Highlights: Black-Right-Pointing-Pointer Custom-building of a high energy broad-beam and a low energy micro-beam XRF Black-Right-Pointing-Pointer In situ analysis of the silvering methods in late Roman nummi with plated surfaces Black-Right-Pointing-Pointer The broad-beam XRF was applied for the detection of mercury traces in the coin alloy. Black-Right-Pointing-Pointer The low energy micro-XRF was used to scan the surface patina of the coins. Black-Right-Pointing-Pointer The correlation between mercury and silver at the coin surface was evidenced.

  10. Cone beam breast CT with multiplanar and three dimensional visualization in differentiating breast masses compared with mammography

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Binghui [Department of Radiology, Shanghai Tenth People' s Hospital, Tongji University, Shanghai 200072 (China); Zhang, Xiaohua [Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY 14627 (United States); Cai, Weixing [Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY 14642 (United States); Conover, David [Koning Corporation, West Henrietta, NY 14586 (United States); Ning, Ruola, E-mail: ruola_ning@urmc.rochester.edu [Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY 14642 (United States)

    2015-01-15

    Objective: This pilot study was to evaluate cone beam breast computed tomography (CBBCT) with multiplanar and three dimensional (3D) visualization in differentiating breast masses in comparison with two-view mammograms. Methods: Sixty-five consecutive female patients (67 breasts) were scanned by CBBCT after conventional two-view mammography (Hologic, Motarget, compression factor 0.8). For CBBCT imaging, three hundred (1024 × 768 × 16 b) two-dimensional (2D) projection images were acquired by rotating the x-ray tube and a flat panel detector (FPD) 360 degree around one breast. Three-dimensional CBBCT images were reconstructed from the 2D projections. Visage CS 3.0 and Amira 5.2.2 were used to visualize reconstructed CBBCT images. Results: Eighty-five breast masses in this study were evaluated and categorized under the breast imaging reporting and data system (BI-RADS) according to plain CBBCT images and two-view mammograms, respectively, prior to biopsy. BI-RADS category of each breast was compared with biopsy histopathology. The results showed that CBBCT with multiplanar and 3D visualization would be helpful to identify the margin and characteristics of breast masses. The category variance ratios for CBBCT under the BI-RADS were 23.5% for malignant tumors (MTs) and 27.3% for benign lesions in comparison with pathology, which were evidently closer to the histopathology results than those of two-view mammograms, p value <0.01. With the receiver operating characteristic (ROC) curve analysis, the area under the curve (AUC) of CBBCT was 0.911, larger than that (AUC 0.827) of two-view mammograms, p value <0.01. Conclusion: CBBCT will be a distinctive noninvasive technology in differentiating and categorizing breast masses under BI-RADS. CBBCT may be considerably more effective to identify breast masses, especially some small, uncertain or multifocal masses than conventional two-view mammography.

  11. 彩色多普勒超声与钼靶X线诊断乳腺癌的对比分析%A comparative analysis of color Doppler ultrasound and mammography x-ray in diagnosis of breast cancer

    Institute of Scientific and Technical Information of China (English)

    刘欣娉; 时伟; 武林松

    2015-01-01

    Objective To discuss the advantages and value of color Doppler ultrasound and X-ray mammography in the diagnosis of breast cancer. Methods Thirty-eight cases of breast cancer pathologically confirmed in our hospital were retrospectively analyzed,and the diagnostic results of ultrasound and molybdenum target X-ray were compared. Results 34 cases were detected in breast ultrasound group, and 4 cases missed;32 cases were detected in mammography X-ray group of breast cancer,and 6 cases missed. Ultrasound group showed a higher rate of mass than mammography X-ray group,and there was no significant difference between the two groups(P>0. 05). There was no significant difference in tumor size and the detection rate of edge levy burr between the two groups(P>0. 05). The blood vessels and lymph node detection rate in ultrasound group was significantly higher than that of mammography X-ray group,microcalcifications detection rate in mammography X-ray group was significantly higher than that in ultrasound group,and the difference was statistically significant(P<0. 05). Conclusion Ultrasound and mammography X-ray play an important role in the diagnosis of breast cancer,and both have their own advanta-ges. If organically combined,they will significantly improve the accuracy of the diagnosis of breast cancer.%目的:探讨彩色多普勒超声及乳腺钼靶X线在乳腺癌诊断中的优势和价值。方法对经术后病理证实的38例乳腺癌患者进行回顾性分析,比较彩超和钼靶X线的诊断结果。结果彩超组检出乳腺癌34例,漏诊4例;钼靶X线组检出乳腺癌32例,漏诊6例,彩超组对肿块的显示率高于钼靶X线组,两组比较差异无统计学意义(P>0.05);对肿块大小、边缘毛刺征的检出率比较,两组比较差异无统计学意义(P>0.05);彩超组对血管和淋巴结的检出率明显高于钼靶X线组,钼靶X线组对微钙化的检出率明显高于彩超组,差

  12. ~(99m)Tc-奥曲肽显像和X线钼靶诊断乳腺癌%~(99m)Tc-octreotide scintigraphy and planar X-ray mammography diagnosis of breast cancer

    Institute of Scientific and Technical Information of China (English)

    何小江; 黄劲雄; 陈贵兵; 俞浩; 吴华

    2009-01-01

    目的 比较~(99m)Tc-奥曲肽显像和X线钼靶诊断乳腺癌的临床应用价值. 方法 32例临床怀疑乳腺癌的女性患者,均进行~(99m)Tc-奥曲肽显像和X线钼靶摄影,以手术病理结果为标准,比较二者对乳腺癌的诊断效能. 结果 ~(99m)Tc-奥曲肽显像和X线钼靶摄影诊断乳腺癌的灵敏度分别为91.67%、66.67%(χ~2=4.54,P<0.05),特异性分别为100%、37.50%(χ~2=4.65,P<0.05),准确性分别为93.75%、59.38%(χ~2=10.54,P<0.05),阳性预测值分别为100%、76.19%(χ~2=5.93,P<0.05),阴性预测值分别为80.00%、27.27%(χ~2=3.92,P<0.05).联合两种方法诊断的灵敏度、特异性、准确性、阳性预测值和阴性预测值分别为95.83%、100%、96.88%、82.14%和47.06%. 结论 ~(99m)Tc-奥曲肽显像对乳腺癌的诊断效能高于X线钼靶摄影,两者联合可进一步提高诊断效能.%Objective To compare the value of (~99m) Tc-octreotide scintigraphy and planar X-ray mammography in the diagnosis of breast cancer. Methods A total of 32 patients with suspected breast cancer were enrolled into this study. All patients underwent (~99m) Tc-octreotide scintigraphy and planar X-ray mammography. The diagnostic efficiency of (~99m) Tc-octreotide scintigraphy and planar X-ray mammography were compared based on the post-surgery pathology. Results The sensitivity of (~99m) Tc-octreotide scintigraphy and planar X-ray mammography in the diagnosis of breast cancer was 91.67% and 66.67%, the specificity was 100% and 37.50%, the accuracy was 93.75% and 59.38%, respectively. Combining (~99m) Tc-octreotide scintigraphy with planar X-ray mammography, the sensitivity, specificity, accuracy, positive predicting values and negative predicting values for breast cancer was 95.83%, 100%, 96.88%, 82.14% and 47.06%, respectively. Conclusion The diagnostic efficiency of (~99m) Tc-octreotide scintigraphy for breast cancer is superior to planar X-ray mammography. (~99m) Tc-octreotide scintigraphy combined with planar X-ray

  13. Optics for coherent X-ray applications

    Energy Technology Data Exchange (ETDEWEB)

    Yabashi, Makina, E-mail: yabashi@spring8.or.jp [RIKEN SPring-8 Center, Kouto 1-1-1, Sayo, Hyogo 679-5148 (Japan); Tono, Kensuke [Japan Synchrotron Radiation Research Institute (JASRI), Kouto 1-1-1, Sayo, Hyogo 679-5198 (Japan); Mimura, Hidekazu [The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan); Matsuyama, Satoshi; Yamauchi, Kazuto [Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871 (Japan); Tanaka, Takashi; Tanaka, Hitoshi; Tamasaku, Kenji [RIKEN SPring-8 Center, Kouto 1-1-1, Sayo, Hyogo 679-5148 (Japan); Ohashi, Haruhiko; Goto, Shunji [Japan Synchrotron Radiation Research Institute (JASRI), Kouto 1-1-1, Sayo, Hyogo 679-5198 (Japan); Ishikawa, Tetsuya [RIKEN SPring-8 Center, Kouto 1-1-1, Sayo, Hyogo 679-5148 (Japan)

    2014-08-27

    Developments of optics for coherent X-ray applications and their role in diffraction-limited storage rings are described. Developments of X-ray optics for full utilization of diffraction-limited storage rings (DLSRs) are presented. The expected performance of DLSRs is introduced using the design parameters of SPring-8 II. To develop optical elements applicable to manipulation of coherent X-rays, advanced technologies on precise processing and metrology were invented. With propagation-based coherent X-rays at the 1 km beamline of SPring-8, a beryllium window fabricated with the physical-vapour-deposition method was found to have ideal speckle-free properties. The elastic emission machining method was utilized for developing reflective mirrors without distortion of the wavefronts. The method was further applied to production of diffraction-limited focusing mirrors generating the smallest spot size in the sub-10 nm regime. To enable production of ultra-intense nanobeams at DLSRs, a low-vibration cooling system for a high-heat-load monochromator and advanced diagnostic systems to characterize X-ray beam properties precisely were developed. Finally, new experimental schemes for combinative nano-analysis and spectroscopy realised with novel X-ray optics are discussed.

  14. Characterization of a triboelectric x-ray spectrum

    Energy Technology Data Exchange (ETDEWEB)

    Moya-Sanchez, E. Ulises; Romo-Espejel, J. A.; Aceves-Aldrete, F. J. [Departamento de Fisica, CUCEI, Universidad de Guadalajara (Mexico)

    2012-10-23

    Low-energy X-ray imaging system has been useful in medical diagnostic in order to obtain high contrast in soft tissue. Recently, Camara et al. and most recently Hird et al. have produced low-energy X-rays using a triboelectric effect. The main aim of this work is to characterize the penetration (beam quality) of a triboelectric X-ray source in terms of the computed Half Value Layer (HVL). Additionally, the computed HVL of the triboelectric X-ray source has been compared with the HVL of X-ray tube Mo-anode (Apogee 5000). According to our computations the triboelectric X-ray source has a similar penetration such as a X-ray tube source.

  15. Calculation of x-ray scattering patterns from nanocrystals at high x-ray intensity

    CERN Document Server

    Abdullah, Malik Muhammad; Son, Sang-Kil; Santra, Robin

    2016-01-01

    We present a generalized method to describe the x-ray scattering intensity of the Bragg spots in a diffraction pattern from nanocrystals exposed to intense x-ray pulses. Our method involves the subdivision of a crystal into smaller units. In order to calculate the dynamics within every unit we employ a Monte-Carlo (MC)-molecular dynamics (MD)-ab-initio hybrid framework using real space periodic boundary conditions. By combining all the units we simulate the diffraction pattern of a crystal larger than the transverse x-ray beam profile, a situation commonly encountered in femtosecond nanocrystallography experiments with focused x-ray free-electron laser radiation. Radiation damage is not spatially uniform and depends on the fluence associated with each specific region inside the crystal. To investigate the effects of uniform and non-uniform fluence distribution we have used two different spatial beam profiles, gaussian and flattop.

  16. Comparison of bactericidal efficiency of 7.5 MeV X-rays, gamma-rays, and 10 MeV e-beams

    Science.gov (United States)

    Song, Beom-Seok; Lee, Yunjong; Moon, Byeong-Geum; Go, Seon-Min; Park, Jong-Heum; Kim, Jae-Kyung; Jung, Koo; Kim, Dong-Ho; Ryu, Sang-Ryeol

    2016-08-01

    This study was performed to verify the feasibility of 7.5 MeV X-rays for food pasteurization through a comparison of the bactericidal efficiency with those of other sources for selected bacterial pathogens. No significant differences were observed between the overall bactericidal efficiency for beef-inoculated pathogens based on the uncertainty of the absorbed dose and variations in bacterial counts. This result supported that all three irradiation sources were effective for inactivation of food-borne bacteria and that 7.5 MeV X-rays may be used for food pasteurization.

  17. X-Ray Astronomy

    Science.gov (United States)

    Wu, S. T.

    2000-01-01

    Dr. S. N. Zhang has lead a seven member group (Dr. Yuxin Feng, Mr. XuejunSun, Mr. Yongzhong Chen, Mr. Jun Lin, Mr. Yangsen Yao, and Ms. Xiaoling Zhang). This group has carried out the following activities: continued data analysis from space astrophysical missions CGRO, RXTE, ASCA and Chandra. Significant scientific results have been produced as results of their work. They discovered the three-layered accretion disk structure around black holes in X-ray binaries; their paper on this discovery is to appear in the prestigious Science magazine. They have also developed a new method for energy spectral analysis of black hole X-ray binaries; four papers on this topics were presented at the most recent Atlanta AAS meeting. They have also carried Monte-Carlo simulations of X-ray detectors, in support to the hardware development efforts at Marshall Space Flight Center (MSFC). These computation-intensive simulations have been carried out entirely on the computers at UAH. They have also carried out extensive simulations for astrophysical applications, taking advantage of the Monte-Carlo simulation codes developed previously at MSFC and further improved at UAH for detector simulations. One refereed paper and one contribution to conference proceedings have been resulted from this effort.

  18. SU-E-P-54: Evaluation of the Accuracy and Precision of IGPS-O X-Ray Image-Guided Positioning System by Comparison with On-Board Imager Cone-Beam Computed Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, D; Wang, W; Jiang, B; Fu, D [Tianjin Medical University Cancer Institute and Hospital, Tianjin, Tianjin (China)

    2015-06-15

    Purpose: The purpose of this study is to assess the positioning accuracy and precision of IGPS-O system which is a novel radiographic kilo-voltage x-ray image-guided positioning system developed for clinical IGRT applications. Methods: IGPS-O x-ray image-guided positioning system consists of two oblique sets of radiographic kilo-voltage x-ray projecting and imaging devices which were equiped on the ground and ceiling of treatment room. This system can determine the positioning error in the form of three translations and three rotations according to the registration of two X-ray images acquired online and the planning CT image. An anthropomorphic head phantom and an anthropomorphic thorax phantom were used for this study. The phantom was set up on the treatment table with correct position and various “planned” setup errors. Both IGPS-O x-ray image-guided positioning system and the commercial On-board Imager Cone-beam Computed Tomography (OBI CBCT) were used to obtain the setup errors of the phantom. Difference of the Result between the two image-guided positioning systems were computed and analyzed. Results: The setup errors measured by IGPS-O x-ray image-guided positioning system and the OBI CBCT system showed a general agreement, the means and standard errors of the discrepancies between the two systems in the left-right, anterior-posterior, superior-inferior directions were −0.13±0.09mm, 0.03±0.25mm, 0.04±0.31mm, respectively. The maximum difference was only 0.51mm in all the directions and the angular discrepancy was 0.3±0.5° between the two systems. Conclusion: The spatial and angular discrepancies between IGPS-O system and OBI CBCT for setup error correction was minimal. There is a general agreement between the two positioning system. IGPS-O x-ray image-guided positioning system can achieve as good accuracy as CBCT and can be used in the clinical IGRT applications.

  19. Precision Survey of X-Rays from $\\overline{p}p (\\overline{p}d)$ Atoms Using the Initial LEAR Beam

    CERN Multimedia

    2002-01-01

    The experiment searches for the K and L X-ray series from @*p~(@*d) atoms, then measures their shift and width relative to QED predictions, and investigates their yields as a function of gas density. \\\\ \\\\ The @* are stopped in 1 atmosphere of H2 (D2) gas in a large aluminium flask whose 1 mm wall thickness eliminates externally produced low energy X-rays. The gas is cooled from a remote helium refrigerator and its temperature varied between 30|0K and 300|0K, giving a density range of 10 and large changes in relative line intensities. With 300~mm|2 area and 250~eV resolution FWHM at 5.9~keV, the Si(Li) X-ray detector penetrates the vacuum to come very close to a large beryllium window. Withstanding the large, charged particle flux from @*p annihilations has required special development of the Si(Li) detector. High purity metals are used for flask, window and detector end-housing to reduce background X-ray lines. A NaI ring suppresses the continuum background that comes principally from Compton scattering in t...

  20. Induction of DNA DSB and its rejoining in clamped and non-clamped tumours after exposure to carbon ion beams in comparison to X rays.

    Science.gov (United States)

    Hirayama, R; Uzawa, A; Matsumoto, Y; Noguchi, M; Kase, Y; Takase, N; Ito, A; Koike, S; Ando, K; Okayasu, R; Furusawa, Y

    2011-02-01

    We studied double-strand breaks (DSB) induction and rejoining in clamped and non-clamped transplanted tumours in mice leg after exposure to 80 keV µm(-1) carbon ions and X rays. The yields of DSB in the tumours were analysed by a static-field gel electrophoresis. The OER of DSB after X rays was 1.68±0.31, and this value was not changed after 1 h rejoining time (1.40±0.26). These damages in oxygenated conditions were rejoined 60-70% within 1 h in situ. No difference was found between the exposure to X rays and carbon ions for the induction and rejoining of DSB. Thus, the values of OER and rejoined fraction after exposure to carbon ions were similar to those after X rays, and the calculated relative biological effectivenesses of carbon ion were around 1 under both oxygen conditions. The yields of DSB in vivo depend on exposure doses, oxygen conditions and rejoining time, but not on the types of radiation quality.

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    Science.gov (United States)

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    Medline Plus

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