WorldWideScience

Sample records for beacon-like response reporting

  1. 2010 responsible growth report

    International Nuclear Information System (INIS)

    2010-01-01

    The report addresses several development and growth perspectives for AREVA: its integrated business model, the synergy and complementarities between nuclear and renewable energies, the sustainable development dimension of its industrial development, its sales revenue result, the reduction of its environmental footprint, its development on all continents, its balanced governance, the simplification of its capital structure, and the actions performed by its Foundation. Then, it discusses ten challenges for the company: ensuring safety and performance throughout the reactor life cycle, making the EPR reactor a standard of safety, maintaining relations based on trust with our stake holders, staying in the lead, accelerating the development of renewable energies, being a trusted partner to growing economies, being a model in mine management, promoting sustainable, effective and safe recycling of used fuel, improving performance continuously, offering development prospects to all employees. It briefly presents ten successes achieved in 2010 and indicates ten sustainable development commitments. Document in French and in English

  2. Responsible Canadian energy progress report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    The Canadian Association of Petroleum Producers (CAPP) represents oil and gas companies throughout Canada; its members produce over 90% of Canada's natural gas and crude oil output. The aim of the Association is to improve the economics of the Canadian upstream petroleum sector in an environmentally and socially responsible way. The aim of this Responsible Canadian Energy report is to present the performance data of CAPP's members for the year 2009. Data, trends, and performance analyses are provided throughout the document. This analysis makes it possible to determine where progress has been made and where performance improvement is necessary. It also presents success stories and best practices so that other companies can learn from them how to improve their own performance. This paper provides useful information on the performance of the upstream petroleum industry in Canada and highlights where the focus should be for further improvement in its performance.

  3. Ombuds’ corner: responsibility and reporting

    CERN Multimedia

    Vincent Vuillemin

    2011-01-01

    In this series, the Bulletin aims to explain the role of the Ombuds at CERN by presenting practical examples of misunderstandings that could have been resolved by the Ombuds if he had been contacted earlier. Please note that, in all the situations we present, the names are fictitious and used only to improve clarity.   Jack* is a new staff member. He joined CERN after having worked successfully in industry, where he had been given considerable responsibility in projects as well as in human resources, despite the fact that he was still young. After a few months, given his expertise, he found himself in charge of part of a project, technically, and also responsible for a few collaborators. That did not present any difficulty for him given his past experience where he was used to handling business in quite an independent way. Also, a high level of respect and ethics had been encouraged by his past employer, which helped him in the interaction with his colleagues. For some tim...

  4. The Neuroscience of Responsibility"-Workshop Report

    NARCIS (Netherlands)

    Vincent, N.A.; Haselager, W.F.G.; Lokhorst, G.J.

    2011-01-01

    This is a report on the 3-day workshop "The Neuroscience of Responsibility" that was held in the Philosophy Department at Delft University of Technology in The Netherlands during February 11th-13th, 2010. The workshop had 25 participants from The Netherlands, Germany, Italy, UK, USA, Canada and

  5. Integrated Disease Surveillance and Response Reporting

    African Journals Online (AJOL)

    stage sampling technique was used to select a sample of 216 primary healthcare workers in. Mangu and Jos South Local ... The intervention group received the training throughout the study and the control at the end. ... Key Words: Training, Integrated Disease Surveillance Response Reporting. Correspondence: Dr Lar, LA ...

  6. Enbridge Inc. 2004 corporate social responsibility report

    International Nuclear Information System (INIS)

    2004-01-01

    This report disclosed information about Enbridge's social programs and initiatives, as well as information concerning environmental issues related to the company's pipeline operations and distribution systems. The report was compiled in response to requests by stakeholders for evidence of Enbridge's social responsibility. An outline of Enbridge's business operations was presented, as well as an overview of corporate governance concerning risk assessment, health and safety. Details of the board's Environmental, Health and Safety Committee were presented. It was noted that Enbridge is now considering broadening the committee's mandate to include responsibility for human rights, community investment, and stakeholder relations. Issues concerning regulatory compliance, review processes and inspections were presented. It was noted that Enbridge received 21 regulatory notifications from government agencies for environmental and safety issues. Details of fugitive emissions management strategies were presented, as well as outlines of internal efficiencies, demand-side management strategies, and renewable and alternative energy offset programs. Enbridge's contributions to climate change policies were discussed. A list of major air emissions released by Enbridge facilities was provided. Details of spills and releases were also provided, as well as water and waste management strategies and environmental outreach programs. Emergency planning procedures were reviewed, as well as details of employer relations, relations with indigenous peoples, human rights and policy development. 6 tabs, 7 figs

  7. Report on responsible growth. AREVA in 2008

    International Nuclear Information System (INIS)

    2009-01-01

    All over the world, AREVA supplies its customers with solutions for carbon-free power generation and electricity transmission and distribution. With its knowledge and expertise in these fields, the group has a leading role to play in meeting the world's energy needs. Ranked first in the global nuclear power industry, AREVA's unique integrated offering covers every stage of the fuel cycle, reactor design and construction, and related services. In addition, the group is expanding its operations in renewable energies. AREVA is also a world leader in electricity transmission and distribution and offers its customers a complete range of solutions for greater grid stability and energy efficiency. Sustainable development is a core component of the group's industrial strategy. Its 75,000 employees work every day to make AREVA a responsible industrial player that is helping to supply ever cleaner, safer and more economical energy to the greatest number of people. Sustainable development is a keystone of AREVA's industrial strategy for achieving growth that is profitable, socially responsible and respectful of the environment. To translate this choice into reality, AREVA integrates sustainable development into its management practices via a continuous improvement initiative revolving around ten commitments: customer satisfaction, financial performance, governance, community involvement, environmental protection, innovation, continuous improvement, commitment to employees, risk management and prevention, dialogue and consensus building. This document is Areva's 2008 report on responsible growth. After the Messages from the Chairman of the Supervisory Board and from the Chief Executive Officer, the report presents the Key data and Highlights of the period, the Corporate governance, the Organization of the group, the Share information and shareholder relations, the uranium reserves, the growing energy demand and the World's population demographic growth, Areva's actions to

  8. Reports, safety recommendations and responses availability

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-19

    A discussion on the U.S. National Transportation Safety Board safety reports covers recommendations to the U.S. Coast Guard, including increased monitoring of vessels carrying/transferring liquefied gases in or near the Port of New Orleans and review of the ''Voluntary Traffic Control Agreement of the Maritime Industry of the Sabine Waterways'' to prevent collisions similar to those involving the ''Inca Tupac Yupanqui'' and the butane barge Panama City in Good Hope, LA, on 8/30/79, the Sea Witch and Esso Brussels in New York Harbor on 6/2/73, and the Mobil Vigilant and Marine Duval, which were carrying 41,198 and 23,866 tons of crude oil and molten sulfur, respectively, near Beaumont, Texas, on 2/25/79; responses by the American Gas Association and the U.S. Department of Transporation on the adequacy of the orginal burial depths of pipelines (Abstract No. 27-51219) and on compliance with hazardous materials regulations, respectively; and other safety recommendations to, and responses by, railroad, aircraft, highway, and federal agencies.

  9. Detecting Careless Responses to Self-Reported Questionnaires

    Science.gov (United States)

    Kountur, Ronny

    2016-01-01

    Problem Statement: The use of self-report questionnaires may lead to biases such as careless responses that distort the research outcomes. Early detection of careless responses in self-report questionnaires may reduce error, but little guidance exists in the literature regarding techniques for detecting such careless or random responses in…

  10. Commercial Building Motor Protection Response Report

    Energy Technology Data Exchange (ETDEWEB)

    James, Daniel P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kueck, John [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-06-17

    When voltages recover, motors may immediately reenergize and reaccelerate, or delay for a few minutes, or stay stalled. The estimated motor response is given for both the voltage sag magnitude and voltage sag duration. These response estimates are based on experience and available test data. Good data is available for voltage sag response for many components such as relays and contactors, but little data is available for both voltage sag and recovery response. The tables in Appendix A include data from recent voltage sag and recovery tests performed by SCE and BPA on air conditioners and energy management systems. The response of the motor can vary greatly depending on the type of protection and control. The time duration for the voltage sag consists of those times that are of interest for bulk power system modelers.

  11. Corporate social responsibility report for 2008

    International Nuclear Information System (INIS)

    Kopriva, J.

    2009-01-01

    The bigger the company the greater its responsibility not only for the development of its housekeeping, but also for the environment, in which it operates. Therefore besides its business activity we are devoting our time to several activities closely related to the world of energy generation. Social responsibility and sustainable development are the priorities. Responsibility starts with individual staff members, as people are the most precious asset. They represent the culture, the direction and management of the company. Education and awareness are of eminent importance for us and this starts at home, behind the doorstep of the power plants. We are a good citizen of Slovakia and we are contributing all our energy into values, which are important, so that the following generations can pass them on. (author)

  12. Rapid Response Manufacturing (RRM). Final CRADA report

    Energy Technology Data Exchange (ETDEWEB)

    Cain, W.D. [Lockheed Martin Energy Systems, Inc., Oak Ridge, TN (United States); Waddell, W.L. [National Centers for Manufacturing Sciences, Ann Arbor, MI (United States)

    1997-08-28

    A major accomplishment of the Rapid Response Manufacturing (RRM) project was the development of a broad-based generic framework for automating and integrating the design-to-manufacturing activities associated with machined part products. Key components of the framework are a manufacturing model that integrates product and process data in a consistent, minimally redundant manner, an advanced computer-aided engineering working environment, knowledge-based software systems for design, process planning, and manufacturing and new production technologies for making products directly from design application software.

  13. The Pepper Commission Report and the response.

    Science.gov (United States)

    1990-01-01

    The recommendations of the "Pepper Commission" [the Bipartisan Commission on Comprehensive Health Care] on health care policy reform (see box on page 20) would cost an estimated $66 billion to implement. As a result, many in Congress already have declared the Pepper report to be politically nonviable. Nevertheless, Commission Chairman John D. Rockefeller IV intends to pursue legislative activity on the report. Recently, Rockefeller said that the Commission's majority recommendations likely will be offered in Congress as one large bill--with the option to break out some of its features for individual consideration. For example, Rockefeller said he will try this year to enact the Commission's recommendations to improve health care coverage for pregnant women and children--as well as suggestions for reform in the health insurance industry. The West Virginia senator said he believes these two proposals will cost about $3.5 billion in new federal funds. The basics of the plan, and the political obstacles facing its enactment, were discussed by several members of the Pepper Commission during the press conference at which the recommendations were unveiled. FAHS Review covered that press conference, and below we reprint excerpts from a tape transcription of the remarks of several Commission members.

  14. Rapid response manufacturing (RRM). Final CRADA report

    Energy Technology Data Exchange (ETDEWEB)

    Cain, W.D. [Lockheed Martin Energy Systems, Inc., Oak Ridge, TN (United States); Waddell, W.L. [National Centers for Manufacturing Sciences, Ann Arbor, MI (United States)

    1998-02-10

    US industry is fighting to maintain its competitive edge in the global market place. Markets fluctuate rapidly. Companies have to be able to respond quickly with improved, high quality, cost efficient products. Because companies and their suppliers are geographically distributed, rapid product realization is dependent on the development of a secure integrated concurrent engineering environment operating across multiple business entities. The way products are developed and brought to market can be improved and made more efficient through the proper incorporation of emerging technologies implemented in a secure environment. This documents the work done under this CRADA to develop capabilities, which permit the effective application, incorporation, and use of advanced technologies in a secure environment to facilitate the product realization process. Lockheed Martin Energy Systems (LMES), through a CRADA with the National Center for Manufacturing Sciences (NCMS), worked within a consortium of major industrial firms--Ford, General Motors, Texas Instruments, United Technologies, and Eastman Kodak--and several small suppliers of advanced manufacturing technology--MacNeal-Schwendler Corp., Teknowledge Corp., Cimplex Corp., Concentra, Spatial Technology, and Structural Dynamics Research Corp. (SDRC)--to create infrastructure to support the development and implementation of secure engineering environments for Rapid Response Manufacturing. The major accomplishment achieved under this CRADA was the demonstration of a prototypical implementation of a broad-based generic framework for automating and integrating the design-to-manufacturing activities associated with machined parts in a secure NWC compliant environment. Specifically, methods needed to permit the effective application, incorporation, and use of advanced technologies in a secure environment to facilitate the product realization process were developed and demonstrated. An important aspect of this demonstration was

  15. Plutonium Reclamation Facility incident response project progress report

    Energy Technology Data Exchange (ETDEWEB)

    Austin, B.A.

    1997-11-25

    This report provides status of Hanford activities in response to process deficiencies highlighted during and in response to the May 14, 1997, explosion at the Plutonium Reclamation Facility. This report provides specific response to the August 4, 1997, memorandum from the Secretary which requested a progress report, in 120 days, on activities associated with reassessing the known and evaluating new vulnerabilities (chemical and radiological) at facilities that have been shut down, are in standby, are being deactivated or have otherwise changed their conventional mode of operation in the last several years. In addition, this report is intended to provide status on emergency response corrective activities as requested in the memorandum from the Secretary on August 28, 1997. Status is also included for actions requested in the second August 28, 1997, memorandum from the Secretary, regarding timely notification of emergencies.

  16. The Responsibility to Protect: Report of the International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Responsibility to Protect: Report of the International Commission on Intervention and State Sovereignty. Book cover The Responsibility to Protect: Report of .... Prévenir l'obésité infantile et améliorer la nutrition au moyen de systèmes d'alimentation de la ferme à l'école en Amérique centrale. Ce projet, mis en oeuvre en ...

  17. Pivotal Response Training. What Works Clearinghouse Intervention Report

    Science.gov (United States)

    What Works Clearinghouse, 2016

    2016-01-01

    This intervention report presents findings from a systematic review of "pivotal response training" conducted using the What Works Clearinghouse Procedures and Standards Handbook (version 3.0) and the Children and Students with an Autism Spectrum Disorder review protocol (version 3.0). "Pivotal response training"…

  18. Quality of criminal responsibility reports submitted to the Hawaii judiciary.

    Science.gov (United States)

    Fuger, Kristen D; Acklin, Marvin W; Nguyen, Annie H; Ignacio, Lawrie A; Gowensmith, W Neil

    2014-01-01

    This paper is the third in a series of research reports on quality of forensic mental health evaluations submitted to the Hawaii judiciary. Previous studies examined quality of reports assessing competency to stand trial (CST) and post-acquittal conditional release, in felony defendants undergoing court-ordered examinations. Utilizing a 44-item quality coding instrument, this study examined quality of criminal responsibility reports in a sample of 150 forensic mental health evaluations conducted between 2006 and 2010 by court-appointed panels. Raters attained high levels of agreement in training and quality coding. Similar to the previous studies, overall quality of reports was mediocre, falling below the .80 quality criterion score for report elements, regardless of evaluator professional identification or employment status. Level of agreement between evaluators and judicial sanity determinations was "fair" using Cicchetti's (1994) standards for interpretation of intra-class correlations. Level of agreement was lower than previously published findings for CST reports and better than conditional release reports. Reasons for mediocre report quality and "fair" inter-rater agreement are discussed, including the fact that criminal responsibility evaluations are complex, retrospective in nature, and involve significant degrees of inference. In contrast to CST evaluations, assessment of criminal responsibility involves a mental state at the time of the offense evaluation. Threats to reliability in forensic reports are discussed. Suggestions for improvement of report quality are proffered, including standardization of procedures and report format and use of forensic assessment instruments. Copyright © 2013 Elsevier Ltd. All rights reserved.

  19. Board Independence and Corporate Social Responsibility (CSR Reporting in Malaysia

    Directory of Open Access Journals (Sweden)

    Nurulyasmin Binti Ju Ahmad

    2017-06-01

    Full Text Available This study aims to examine the influence of board independence on corporate social responsibility (CSR reporting by publicly listed companies in Malaysia. Content analysis was used to determine the extent of CSR reporting. A reporting index consisting of 51 items was developed based on six themes: General, Community, Environment, Human Resources, Marketplace and Other. An Ordinary Least Square (OLS regression was used to examine the relationship between board independence and firm CSR reporting. The results indicate that the association between board independence and company CSR reporting is industry specific. Overall, the empirical evidence partially supports agency theory.

  20. Board Independence and Corporate Social Responsibility (CSR) Reporting in Malaysia

    OpenAIRE

    Nurulyasmin Binti Ju Ahmad; Afzalur Rashid; Jeff Gow

    2017-01-01

    This study aims to examine the influence of board independence on corporate social responsibility (CSR) reporting by publicly listed companies in Malaysia. Content analysis was used to determine the extent of CSR reporting. A reporting index consisting of 51 items was developed based on six themes: General, Community, Environment, Human Resources, Marketplace and Other. An Ordinary Least Square (OLS) regression was used to examine the relationship between board independence and fi...

  1. Ipilimumab in advanced melanoma: reports of long-lasting responses.

    Science.gov (United States)

    Farolfi, Alberto; Ridolfi, Laura; Guidoboni, Massimo; Nicoletti, Stefania Vittoria Luisa; Piciucchi, Sara; Valmorri, Linda; Costantini, Matteo; Scarpi, Emanuela; Amadori, Dino; Ridolfi, Ruggero

    2012-06-01

    Patients with metastatic melanoma have a poor prognosis; the results of chemotherapy remain unsatisfactory. Ipilimumab, an anticytotoxic T lymphocyte-associated antigen-4 antibody, has shown promising results in several clinical trials. In this report, advanced melanoma patients receiving ipilimumab were scored according to novel immune-related response criteria (irRC) in an attempt to capture additional response patterns and to avoid premature treatment cessation. Thirty-six heavily pretreated metastatic melanoma patients recieved ipilimumab within five international clinical trials at our Institution from May 2006 to August 2008. Disease progression was defined as an increase in tumor burden by at least 25% compared with the nadir, irrespective of any initial increase in baseline lesions or the appearance of new lesions. We report unusually long-lasting responses in patients treated with ipilimumab 10 mg/kg. An overall response was observed in six out of 30 patients (20%), a complete response in three (10%), and disease control in 11 (37%), which seemed to be of a long duration (median of 16 months; complete response 36+, 34+, and 41+ months). All irRC patterns seemed to be strongly associated with an improvement in overall survival. Interestingly, we found a correlation between the presence of a grade 3/4 immune-related adverse event and responses, time to progression, and overall survival. Ipilimumab therapy resulted in clinically meaningful responses in advanced melanoma patients, supporting the need for further irRC validation.

  2. Responsible Development of AREVA's Mining Activities - Report 2012

    International Nuclear Information System (INIS)

    2013-09-01

    By defining AREVA's strategy and policies, this report aims to demonstrate the company's performance in the key areas of mining activity responsibility: ethics and governance, social report, the environment, occupational health and safety, community involvement, commitments to stakeholders. The data given cover the assets for which AREVA acts as operator in uranium mining activities: exploration, project development, production and rehabilitation. The consolidated data target activities in France, Canada, Niger, Kazakhstan, Mongolia, Gabon and Namibia. Activities in the Central African Republic and those linked to La Mancha no longer fall within the scope of this report (sale of assets in 2012). This report is the third edition of this annual exercise

  3. The social-financial responsible reporting – the key for integrated reporting

    Directory of Open Access Journals (Sweden)

    Iulia Jianu

    2012-08-01

    Full Text Available General purpose of financial statements is to satisfy the needs of users who are not in the position to require of the entity to prepare reports tailored to their particular information needs. Because the public is one of these users interested of social information and because the financial statement do not provide sufficient social information to satisfy these needs, the study demonstrate the need to integrate the responsible social reporting into financial reporting. In order to support this reason, taking into account the data supplied by the entities listed on the Global Reporting Initiative regarding the corporate social responsibility. The results of the study show that social indicators can be disclosed in a monetary form which reinforces the need for their integration into financial reporting and the need to define a new concept: the social – financial responsible reporting.

  4. CSR and CSR Reporting: Reporting as a way to create Socially Responsible Business

    Directory of Open Access Journals (Sweden)

    Fabio Andrés Bonilla Sanabria

    2011-12-01

    In this scenario the Reporting of Non-Financial Information is studied as a way to create socially responsible businesses. In addressing the reporting of non-financial information, the article provides a state of affairs regarding reporting and considers specific examples of disclosure of corporate information. The CSR battle has been transferred to the reporting of non-financial information but in this field there are many difficulties unresolved and challenges ahead.

  5. Self-Report and Psychophysiological Responses to Fear Appeals

    Science.gov (United States)

    Ordonana, Juan R.; Gonzalez-Javier, Francisca; Espin-Lopez, Laura; Gomez-Amor, Jesus

    2009-01-01

    This study was designed to assess the relationship between self-report and psychophysiological responses to fear appeals and behavioral changes elicited by these. Ninety-two subjects watched one of four messages that varied in level of threat (high vs. low) and efficacy (high vs. low). Concomitantly, psychophysiological measures (heart rate and…

  6. Report of the emergency preparedness and response task force

    International Nuclear Information System (INIS)

    Dynes, R.R.; Purcell, A.H.; Wenger, D.E.; Stern, P.S.; Stallings, R.A.; Johnson, Q.T.

    1979-10-01

    The accident at Three Mile Island (TMI) marked the first time in the US when traditional planning for emergencies was applied to a possible radiological emergency. This report examines the planning that existed in the counties surrounding the plant and at the state and federal levels. It also examines the responses of the various governmental units following the initial accident

  7. Report of the Emergency Preparedness and Response Task Force

    International Nuclear Information System (INIS)

    Dynes, R.R.; Purcell, A.H.; Wenger, D.E.; Stern, P.S.; Stallings, R.A.; Johnson, Q.T.

    1979-10-01

    The accident at Three Mile Island (TMI) marked the first time in the US when traditional planning for emergencies was applied to a possible radiological emergency. This report examines the planning that existed in the counties surrounding the plant and at the state and federal levels. It also examines the responses of the various governmental units following the initial accident

  8. Fraudulent Financial Reporting: Education's Response to a National Problem.

    Science.gov (United States)

    Bayes, Paul E.; And Others

    1993-01-01

    Responses from 35 of 79 accounting-accredited business schools, 63 of 148 accredited in business only by the American Association of Collegiate Schools of Business (AACSB), and 88 of 205 non-AACSB accredited schools indicated minimal coverage of fraudulent financial reporting in course content. Accounting-accredited schools had greatest breadth of…

  9. ANALYZING CORPORATE SOCIAL RESPONSIBILITY REPORTING IN THE EUROPEAN UNION

    Directory of Open Access Journals (Sweden)

    ANDREESCU Nicoleta Alina

    2016-05-01

    Full Text Available In the context of national and international developments, Corporate Social Responsibility is becoming an increasingly important element on national and transnational policy agendas. An ever more diverse range of businesses are adopting CSR strategies as a core part of their business model. Socially responsible business can contribute to restoring trust in the market in the post-crisis context. In last years European Commission encouraging international business development and in same time, CSR instruments development in all types of organizations for encourage responsible business conduct. In this paper our purpose was to analyse the current stage of CSR in the EU. For this, we divided our research in two parts: in first part we analyze the current stage of CSR reporting of the EU members and in the second part, we study the organizational sectors of company which fulfill their report of sustainability. Our results prove us that are a few factors that influence the current stage of reporting and in last years number of company that report their CSR activity is increasing in all sectors and in all countries. Given the fact that CSR activities are becoming more and more important in any successful business, and taking into account the legislative changes that took place in European Laws, we consider CSR reporting to be even more intense in the years to follow, in EU member states.

  10. Responses on the report 'Discovery of the transfermium elements'

    International Nuclear Information System (INIS)

    Ghiorso, A.; Seaborg, G.T.; Organessian, Yu.Ts.

    1993-01-01

    Responses to the concluding report of the Transfermium Working Group (TWG) of the International Union of Pure and Applied Physicists and the International union of Pure and Applied Chemists are presented. The responses emanate from the three laboratories of chief concern who were calculated by the TWG in the preparation of their work. Whilst commending the TWG and its report, two laboratories, the Joint Institute for Nuclear Research at Dubna, and the Gesellschaft fur Schwerionenforschung at Darmstadt, have comments to make about the naming of some of the elements in the group. The comments made by the Lawrence Berkeley Laboratory, California, are more critical and specific, particularly with respect to elements 101 to 106. Having made a detailed examination of these criticisms, the TWG do no find it necessary to change in any way the conclusions of their report, Parts II and III of which are published in this issue of this journal, and Part I in an earlier issue. (UK)

  11. Recurrent hypersomnia: Report of medication-responsive cases

    Science.gov (United States)

    Perin, Bruna V.; Rodrigues, Iorrana; Giasson, Franciele T.B.; Balen, Matheus; Posenato, Naiana; Forcelini, Cassiano M.

    2015-01-01

    Introduction Recurrent hypersomnia (RH) is a rare disorder without established treatment. Methods We report 2 RH medication-responsive cases with typical characteristics of Kleine–Levin syndrome (KLS). Case-reports A 10 y.o. girl and a 14 y.o. boy presented with sudden sleepiness for 3–9 days (every 2–3 weeks). Physical examination, brain images and blood tests were normal. Polysomnographic findings were heterogenous, including disrupted sleep architecture. MSLTs revealed 2–3 SOREMPs and short sleep latency. Carbamazepine rendered girl׳s sleep normalization, while risperidone normalized boy׳s sleep cycles. Conclusions Facing the absence of clinical trials in RH, reports of responsive cases are the available therapeutic evidence. PMID:26483951

  12. The Social-Financial Responsible Reporting – The Key for Integrated Reporting

    OpenAIRE

    Iulia Jianu

    2012-01-01

    General purpose of financial statements is to satisfy the needs of users who are not in the position to require of the entity to prepare reports tailored to their particular information needs. Because the public is one of these users interested of social information and because the financial statement do not provide sufficient social information to satisfy these needs, the study demonstrate the need to integrate the responsible social reporting into financial reporting. In order to support th...

  13. [Responsibility of health providers in domestic violence reporting].

    Science.gov (United States)

    Saliba, Orlando; Garbin, Cléa Adas Saliba; Garbin, Artênio José Isper; Dossi, Ana Paula

    2007-06-01

    Domestic violence reporting by health providers contributes to the epidemiological assessment of the magnitude of the problem, which allows the development of specific programs and actions. The aim of the study was to assess the level of responsibility of these providers towards reporting violence, especially domestic violence, and potential related legal and ethical implications. The Brazilian legislation and ethics code of Medicine, Dentistry, Nursing and Psychology were studied. Legal sanctions are found in the Criminal Law of Misdemeanor Offenses, the Child and Adolescent Statute, the Elderly Statute and in the law establishing mandatory reporting of violence against women. There are also penalties in all ethics codes reviewed. It is concluded that health providers have the legal duty of reporting known domestic violence cases and they can even be charged with omission.

  14. Bronchodilator responsiveness and reported respiratory symptoms in an adult population.

    Directory of Open Access Journals (Sweden)

    Wan C Tan

    Full Text Available BACKGROUND: The relationship between patient-reported symptoms and objective measures of lung function is poorly understood. AIM: To determine the association between responsiveness to bronchodilator and respiratory symptoms in random population samples. METHODS: 4669 people aged 40 years and older from 8 sites in Canada completed interviewer-administered respiratory questionnaires and performed spirometry before and after administration of 200 ug of inhaled salbutamol. The effect of anthropometric variables, smoking exposure and doctor-diagnosed asthma (DDA on bronchodilator responsiveness in forced expiratory volume in 1 second (FEV1 and in forced vital capacity (FVC were evaluated. Multiple logistic regression was used to test for association between quintiles of increasing changes in FEV1 and in FVC after bronchodilator and several respiratory symptoms. RESULTS: Determinants of bronchodilator change in FEV1 and FVC included age, DDA, smoking, respiratory drug use and female gender [p<0.005 to p<0.0001 ]. In subjects without doctor-diagnosed asthma or COPD, bronchodilator response in FEV1 was associated with wheezing [p for trend<0.0001], while bronchodilator response for FVC was associated with breathlessness. [p for trend <0.0001]. CONCLUSIONS: Bronchodilator responsiveness in FEV1 or FVC are associated with different respiratory symptoms in the community. Both flow and volume bronchodilator responses are useful parameters which together can be predictive of both wheezing and breathlessness in the general population.

  15. Do Cross-Listed Firms Report Better Social Responsibility Performance?

    Directory of Open Access Journals (Sweden)

    Liu Guangyou

    2017-01-01

    Full Text Available This paper investigates the corporate social responsibility (CSR disclosure of cross-listed companies in China, to bridge the gap between existent CSR literature and the literature on cross-listing. Mann- Whitney-U and Wilcoxon ranking tests document the traditional bonding effect regarding reported corporate financial performance. Furthermore, the test results and findings of this study extend the financial bonding effect to other dimensions of corporate responsibility. In addition to better economic returns to owners, the bonding effect marks better reported CSR performance for cross-listed companies in terms of pay raises for employees, creation of new jobs, desirable stock option plans for management, and increased input in environmental protection and energy-saving activities.

  16. Areva 2009 responsible growth report: more energy, less CO2

    International Nuclear Information System (INIS)

    2009-01-01

    This document is the 2009 annual responsible growth report of AREVA which presents itself as having consolidated its leadership position in its original business of nuclear power while expanding considerably in renewable energies (wind, solar, bio-energies and hydrogen/storage) to become a leading provider of solutions for carbon-free power generation. The main chapters of the report are: the group and its strategy, Areva's nuclear power solutions (is nuclear a sustainable energy source?, supply, technological excellence, safety, recycling and waste, acceptability, non-proliferation), Areva's renewable energy solutions (how much of the energy mix should be renewable?, rising demand, competitiveness and efficiency, responsible development), Areva's human resources (gender balance, health and safety, diversity and opportunity, hiring and training). Data and balanced scorecard for sustainable development are also given

  17. Corporate responsibility reporting according to Global Reporting Initiative: an international comparison

    Directory of Open Access Journals (Sweden)

    Ionela-Corina CHERSAN

    2016-04-01

    Full Text Available The Global Reporting Initiative (GRI is an organization that has managed to impose its reporting practices on corporate responsibility among large transnational companies. The model proposed by GRI is based on the supposed convergence between the economic, social and environmental dimensions of sustainable development. This convergence can be presumed at macroeconomic level, but at the level of enterprises, the three dimensions are often divergent. By analyzing the structure of reports included in the GRI database, our article aims to identify the factors that impact on company’s behavior in the corporate responsibility reporting process. In addition, our research invites to answer the following question: is it not possible that these reports attempt to exaggerate company environmental and social performance, rather than to cause a change in their conduct?

  18. Responsible Reporting: Neuroimaging News in the Age of Responsible Research and Innovation.

    Science.gov (United States)

    de Jong, Irja Marije; Kupper, Frank; Arentshorst, Marlous; Broerse, Jacqueline

    2016-08-01

    Besides offering opportunities in both clinical and non-clinical domains, the application of novel neuroimaging technologies raises pressing dilemmas. 'Responsible Research and Innovation' (RRI) aims to stimulate research and innovation activities that take ethical and social considerations into account from the outset. We previously identified that Dutch neuroscientists interpret "responsible innovation" as educating the public on neuroimaging technologies via the popular press. Their aim is to mitigate (neuro)hype, an aim shared with the wider emerging RRI community. Here, we present results of a media-analysis undertaken to establish whether the body of articles in the Dutch popular press presents balanced conversations on neuroimaging research to the public. We found that reporting was mostly positive and framed in terms of (healthcare) progress. There was rarely a balance between technology opportunities and limitations, and even fewer articles addressed societal or ethical aspects of neuroimaging research. Furthermore, neuroimaging metaphors seem to favour oversimplification. Current reporting is therefore more likely to enable hype than to mitigate it. How can neuroscientists, given their self-ascribed social responsibility, address this conundrum? We make a case for a collective and shared responsibility among neuroscientists, journalists and other stakeholders, including funders, committed to responsible reporting on neuroimaging research.

  19. Talisman Energy Inc : corporate social responsibility report 2001 : Sudan operations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    Talisman Energy Inc. is a large independent Canadian oil and gas producer with operations worldwide, including operations in Sudan, Malaysia, Trinidad and Colombia. This report includes a discussion on seismic exploration in the Acevedo block in Colombia, but most of the report focuses on operations in Sudan because that is the primary concern of many stakeholders, particularly the impact of the long-running civil war in that country and the way in which oil revenues will be used. The report describes Talisman Energy's compliance with the International Code of Ethics for Canadian Business which Talisman adopted in December 1999. The report evaluates Talisman's progress towards achieving objectives in the areas of human rights, community participation, employee rights, ethical business conduct, health, safety and the environment. Talisman will continue to advocate peace and the fair distribution of oil revenues. It was noted that the funding provided by the Sudan oil project consortium Greater Nile Petroleum Operating Company (GNPOC) for community development was increased for 2002. Talisman and GNPOC funding helps in community development initiatives such as the provision of water wells, health clinics and schools in Sudan. PricewaterhouseCoopers (PwC) was asked by Talisman to gather comments on the company's operations in Sudan from a range of stakeholder groups. This report presents audit statements by PwC regarding Talisman's social responsibility. The report also included an independent opinion regarding the challenge of facing ethical dilemmas in business. tabs., figs.

  20. Responsive copolymers for enhanced petroleum recovery. Annual report

    Energy Technology Data Exchange (ETDEWEB)

    McCormick, C.; Hester, R.

    1994-08-01

    A coordinated research program involving synthesis, characterization, and rheology has been undertaken to develop advanced polymer system which should be significantly more efficient than polymers presently used for mobility control and conformance. Unlike the relatively inefficient, traditional EOR polymers, these advanced polymer systems possess microstructural features responsive to temperature, electrolyte concentration, and shear conditions. Contents of this report include the following chapters. (1) First annual report responsive copolymers for enhanced oil recovery. (2) Copolymers of acrylamide and sodium 3-acrylamido-3-methylbutanoate. (3) Terpolymers of NaAMB, Am, and n-decylacrylamide. (4) Synthesis and characterization of electrolyte responsive terpolymers of acrylamide, N-(4-butyl)phenylacrylamide, and sodium acrylate, sodium-2-acrylamido-2-methylpropanesulphonate or sodium-3-acrylamido-3-methylbutanoate. (5) Synthesis and solution properties of associative acrylamido copolymers with pyrensulfonamide fluorescence labels. (6) Photophysical studies of the solution behavior of associative pyrenesulfonamide-labeled polyacrylamides. (7) Ampholytic copolymers of sodium 2-(acrylamido)-2-methylpropanesulfonate with [2-(acrylamido)-2-methypropyl]trimethylammonium chloride. (8) Ampholytic terpolymers of acrylamide with sodium 2-acrylamido-2-methylpropanesulphoante and 2-acrylamido-2-methylpropanetrimethyl-ammonium chloride and (9) Polymer solution extensional behavior in porous media.

  1. REPORTING CORPORATE SOCIAL RESPONSIBILITY ACCORDING TO GRI STANDARDS

    Directory of Open Access Journals (Sweden)

    Berinde Mihai

    2015-07-01

    Full Text Available Corporate social responsibility is no longer considered an optional activity by companies. The changes that take place worldwide have determined an increasing number of companies to elaborate instruments of implementing CSR principles into their business strategy. A CSR policy adapted to the specifics of the company’s field of activity and to the community in which it is present will bring advantages for both parties. The way through which a company makes their CSR activity results public is by writing a sustainability report which corresponds to international practices in the field. In recent years, an increasing number of companies publish their yearly CSR reports. This reporting originated in the USA, but in the last decade, the number of reports from Europe is increasing. In order to answer to the needs of reporting of the companies, a series of nongovernmental organisms have involved in trying to find the most accessible way that would correspond to the needs of the companies and of the stakeholders. Global Reporting Initiative is a platform that came to the aid of the companies by creating reporting standards which to guide companies through the process of creating the sustainability report. In this paper, we have analysed the evolution in the number of CSR reports worldwide, having then analysed their distribution on continents. We have given attention to the situation in Romania, which in the past ten years, due to multinational companies coming in the market. The presence of multinational companies has helped develop this concept. In the past five years, Romanian companies have submitted CSR reports according to GRI standards. Although the percent of companies of Romanian companies that submit reports according to the GRI standards is small (0.0017%, we believe that it will grow in following years, due to companies realizing the role they have in the society and because the European Commission’s 2014/95/EU Directive will enter into

  2. Sharing our energies. Corporate social responsibility report 2005

    International Nuclear Information System (INIS)

    2006-05-01

    Total is a multinational energy company, the fourth largest publicly-traded integrated oil and gas company in the world. Total worldwide operations are conducted through three business segments: Upstream includes oil and gas Exploration and Production, Gas and Power and other energy sources. Downstream covers Trading and Shipping,Refining and the Marketing of TOTAL and Elf brand petroleum products, automotive and other fuels, and specialties such as LPG, aviation fuel and lubricants, through both the retail network and other outlets worldwide. Chemicals comprises various activities including Base chemicals (Petrochemicals and Fertilizers) and Specialties for industry and the consumer market. This corporate social responsibility report presents the Group activity for the year 2005 in the following domains: the business principles, the environment safety and health, the social responsibility and the local development, the future of energy (fossil fuels, renewable energies and towards energy vectors). (A.L.B.)

  3. Responsible Development of Areva's Mining Activities. Report 2011

    International Nuclear Information System (INIS)

    2012-09-01

    After a presentation of the approach to responsibility adopted by AREVA to be a responsible mining stake holder (charter of values, implemented policies, risk prevention and management, best practices), this report gives an overview of mining activities (international presence, production in constant increase) with a focus on uranium mining which is the core business (the different phases are briefly presented: exploration, project development, mining, site decommissioning). It outlines personnel qualification and commitment, actions and policy in the field of personnel health and safety. It addresses the environmental policy: key levers, environmental management system, examples throughout the entire mining life cycle, changes in site consumptions and emissions, promotion of biodiversity. The next part concerns Areva's social commitment (dialogue, development aid in mining territories). Then, performance is expressed in terms of indicators for these different issues (teams, environmental policy, social involvement)

  4. Report of nuclear utility industry responses to Kemeny Commission recommendations

    International Nuclear Information System (INIS)

    1989-02-01

    The purpose of this paper is to provide a report of nuclear utility industry progress in responding to the recommendations of the President's Commission on the Accident at Three Mile Island (The Kemeny Commission). On April 11, 1979, in response to TMI, President Carter established a Commission to conduct '.... a comprehensive study and investigation of the recent accident involving the nuclear power facility on Three Mile Island in Pennsylvania'. The Commission was chaired by Dr. John G. Kemeny, then President of Dartmouth College. (A list of all members of The Kemeny Commission is provided in Attachment to the Appendix ). The report of the commission's findings and recommendations was transmitted to the President in October 1979. During this same period, the nuclear utility industry responded to TMI by creating the Institute of Nuclear Power Operations (INPO) with a mission to promote the highest levels of safety and reliability - to promote excellence - in the operation of nuclear electric generating plants. In addition, the Nuclear Safety Analysis Center (NSAC) was established at the Electric Power Research Institute (EPRI to evaluate the accident and assist in determining the best industry response. In a White House paper (and press release) of December 7 1979, the President announced that he agreed fully with the spirit and intent of al the Kemeny Commission recommendations and requested that the industry and The Nuclear Regulatory Commission (NRC) comply with the recommendations. The President also recognized the industry initiative in establishing INPO and called for several actions involving the Institute; the President directed the Department of Energy and other government agencies to provide assistance to INPO and the industry. An overall status of the nuclear utility industry responses to Kemeny Commission recommendations in the key areas directly related to nuclear plant operations is provided below. A more detailed status of industry responses to the

  5. [Legitimizing and responsibilities of public health reports: public health reports or social court reports?].

    Science.gov (United States)

    Borgers, D; Streich, W

    1996-11-01

    Since 1970 various initiatives have been taken to improve the information bases of health reporting. However, the efforts made up to now by the Länder, the Federal Government and its corporate bodies are characterised by a lack of experience and shortage of resources; moreover, they are viewed with a critical eye by the public and in the political area. In this contribution the authors describe various topics and delimitations of a health reporting system which go far beyond health statistics and health programmes altogether. The chances of a national health reporting system are based on the assumption that an objective judgement based on expert knowledge and science will be possible and that beyond all particularistic interests, expert knowledge can be organised in a democratic process. Public health reporting varies between two extremes: On the one hand, the current reporting in the media on health-related subjects which is characterised by disagreement among experts, particularistic interests and emotions, and on the other hand the national health reporting, which, on the platform of policy marketing and political image shaping, is suspected of degenerating to a kind of "royal court reporting". A health reporting system based on expert knowledge and characterised by topics with relevance to health policy, expert quality of its information and neutrality to particularistic interests, should go beyond these two extremes. Given the political conditions of budgeting and distribution conflicts, health reporting has to deal with two main aspects: effectiveness and efficiency of employed resources and with the problems of a fair distribution of these resources to provide equal chances in the health sector. What cannot be solved, by questions of procedure, however, is the problem of truth and objective knowledge as well as the problem of confidence. If the general public lacks confidence in national expert knowledge, a society discourse will not lead to political

  6. Containment atmosphere response (CAR) program. Second status report. [HTGR

    Energy Technology Data Exchange (ETDEWEB)

    Landoni, J.A.

    1980-03-01

    This report contains a summary of the work performed under the Containment Atmosphere Response (CAR) Program of the High-Temperature Gas-Cooled Reactor (HTGR) Safety Research Task since the publication of the previous status report (February 1978). The work concentrated on development of models describing containment phenomena during core heatup in support of probabilistic risk assessment studies. Models were completed for fission product iodine sorption on coated surfaces, diffusivity and retentivity of untreated concrete, iodine interaction with condensing steam on the containment atmosphere boundaries, and the cleanup filter system. These models were incorporated into a new computer program called CARCAS, a substantial extension of the CNTB computer program, and applied to Accident Initiation and Progression Analysis for Phase II core heatup sequences. Development was begun on models describing the postulated behavior of particulate fission products or aerosols within and leaking out of the containment.

  7. Containment atmosphere response (CAR) program. Second status report

    International Nuclear Information System (INIS)

    Landoni, J.A.

    1980-03-01

    This report contains a summary of the work performed under the Containment Atmosphere Response (CAR) Program of the High-Temperature Gas-Cooled Reactor (HTGR) Safety Research Task since the publication of the previous status report (February 1978). The work concentrated on development of models describing containment phenomena during core heatup in support of probabilistic risk assessment studies. Models were completed for fission product iodine sorption on coated surfaces, diffusivity and retentivity of untreated concrete, iodine interaction with condensing steam on the containment atmosphere boundaries, and the cleanup filter system. These models were incorporated into a new computer program called CARCAS, a substantial extension of the CNTB computer program, and applied to Accident Initiation and Progression Analysis for Phase II core heatup sequences. Development was begun on models describing the postulated behavior of particulate fission products or aerosols within and leaking out of the containment

  8. Large Granular Lymphocytic Leukemia: A Report of Response to Rituximab

    Directory of Open Access Journals (Sweden)

    Uroosa Ibrahim

    2017-01-01

    Full Text Available Large granular lymphocytic (LGL leukemia is a rare form of low grade leukemia characterized by large cytotoxic T cells or natural killer cells on morphological examination. Immunosuppressive therapy is employed as first-line therapy. Treatment options in refractory cases include the anti-CD52 antibody alemtuzumab and purine analogues. We report a rare case that responded to the anti-CD20 monoclonal antibody rituximab. A 77-year-old female presented with complaints of fatigue, fever, and chills of 3 months’ duration. A CBC showed that pancytopenia with an absolute neutrophil count (ANC was 0. Peripheral blood flow cytometry detected increased number of T cell large granular lymphocytes and T cell receptor rearrangement study detected a clonal T cell population. Bone marrow biopsy showed peripheral T cell lymphoma, most consistent with T-large granulocytic leukemia. The patient was treated with prednisone and oral cyclophosphamide for four months with no response. Thereafter, she received four weekly infusions of rituximab with improvement in her blood counts. A response to rituximab in refractory cases such as ours has been reported and may guide us towards exploring other immune-based therapeutics in this rare disease.

  9. The environmental commitment and responsibility program: Industry annual report 1998

    International Nuclear Information System (INIS)

    1999-01-01

    The Environmental Commitment and Responsibility Program is an industry-wide initiative of the corporate electric utility members of the Canadian Electrical Association. The Program is in its second year; it builds on individual initiatives of member utilities and provides a forum to address the industry's stated commitment to sustainable development and improved environmental performance. This annual report provides an account of progress and development during 1998. It is organized in terms of the four principles underlying the industry's commitment to environmental stewardship, namely: (1) greater efficiency in the use of resources, (2) reduction of adverse environmental impact of the industry, (3) accountability to constituents, and (4) fostering of environmental awareness through facilitating the acquisition of environmental knowledge and skills among employees. Besides reporting progress by most member utilities in all or most of these areas, the report also provides a glimpse into the future towards implementing environmental management systems, an independent verification process, development of new indicators of progress in the area of treated wood used in distribution and transmission poles, and in assessing the impact of hydroelectric facilities on fish habitat. A table of indicators and protocols established in 1997 and 1998 and progress on each to date is appended

  10. Zinc-responsive dermatosis in mixed breed dog - Case report

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Fonseca Alves

    2015-06-01

    Full Text Available ABSTRACT. Fonseca-Alves C.E., Vicente I.S.T., Parente L.M.L. & Conceição M. [Zinc-responsive dermatosis in mixed breed dog - Case report.] Dermatose responsiva a zinco em cão sem raça definida - Relato de caso. Revista Brasileira de Medicina Veterinária, 37(2:120-122, 2015. Programa de Pós-Graduação em Medicina Veterinária, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista “Julio de Mesquita Filho”-Unesp, Distrito de Rubião Jr s/n, Botucatu, SP 18618-970, Brasil. E-mail: carloseduardofa@hotmail.com Zinc is an essential mineral of the diet and it deficiency can happen in the dietary lack and in genetic abnormalities. Zinc deficiency is characterized for alterations in immune system, in growth and development, as well as lesions gastro-intestinal and in the skin. A male dog mixed breed, with eight years of age, was assisted at the Veterinary Hospital, presenting compatible clinical signs with that deficiency. The animal received supplementation with zinc with metionine, with total improvement of the process. The paper reports a case of zinc deficiency in a mixed breed dog.

  11. Report on the 2010 Chilean earthquake and tsunami response

    Science.gov (United States)

    ,

    2011-01-01

    disaster response strategies and operations of Chilean agencies, including perceived or actual failures in disaster preparation that impacted the medical disaster response; post-disaster health and medical interventions to save lives and limit suffering; and the lessons learned by public health and medical personnel as a result of their experiences. Despite devastating damage to the health care and civic infrastructure, the health care response to the Chilean earthquake appeared highly successful due to several factors. Like other first responders, the medical community had the ability and resourcefulness to respond without centralized control in the early response phase. The health care community maintained patient care under austere conditions, despite many obstacles that could have prevented such care. National and international resources were rapidly mobilized to support the medical response. The Emergency Services Team sought to collect information on all phases of emergency management (preparedness, mitigation, response, and recovery) and determine what worked well and what could be improved upon. The Chileans reported being surprised that they were not as ready for this event as they thought they were. The use of mass care sheltering was limited, given the scope of the disaster, because of the resiliency of the population. The impacts of the earthquake and the tsunami were quite different, as were the needs of urban and rural dwellers, necessitating different response activities. The Volunteer Services Team examined the challenges faced in mobilizing a large number of volunteers to assist in the aftermath of a disaster of this scale. One of the greatest challenges expressed was difficulty in communication; the need for redundancy in communication mechanisms was cited. The flexibility and ability to work autonomously by the frontline volunteers was a significant factor in effective response. It was also important for volunteer leadership to know the emergency plans

  12. CSR and CSR Reporting: Reporting as a way to create Socially Responsible Business

    Directory of Open Access Journals (Sweden)

    Fabio Andrés Bonilla Sanabria

    2011-12-01

    Full Text Available Admitting the theory of a company being a set of multiple interests, the first part of this article intends to give an overview of the Shareholder and Stockholders models in the Corporate Social Responsibility debate. The prevailing view in western Company Law (the cases of the UK and US are considered is that of the Shareholder Wealth Maximization model. For the author of the article, events such as the financial crisis showed that the financial conditions of companies giving its‘ extended effects should give way to calls for public accountability in company management. However there seems to be a deadlock given that the prevailing model favours shareholders.In this scenario the Reporting of Non-Financial Information is studied as a way to create socially responsible businesses. In addressing the reporting of non-financial information, the article provides a state of affairs regarding reporting and considers specific examples of disclosure of corporate information. The CSR battle has been transferred to the reporting of non-financial information but in this field there are many difficulties unresolved and challenges ahead.

  13. Media awards for responsible reporting of suicide: Experiences from Australia, Belgium and Denmark

    DEFF Research Database (Denmark)

    Dare, Andrew J; Andriessen, Karl Am; Nordentoft, Merete

    2011-01-01

    Media awards to encourage responsible reporting of suicide have been introduced in several countries, including Australia, Belgium and Denmark.......Media awards to encourage responsible reporting of suicide have been introduced in several countries, including Australia, Belgium and Denmark....

  14. Expected Risk Assessment—Annual Report versus Social Responsibility

    Directory of Open Access Journals (Sweden)

    Elvira Böcskei

    2015-07-01

    Full Text Available Global economic, social and environmental changes are inspiring companies to behave responsibly towards the environment, not only in the interest of others, but also in that of the future of their companies. It is crucial that companies are able to recognize any lack in their ability to grow values in a timely manner, because issues at companies require immediate intervention. A key factor in maintaining operations is the time interval required for companies to adjust to challenges. Are Annual Reports capable of indicating problems or possibly to inform decision-makers that a company is entering a period of decline? Such information can be gathered from the notes to the financial statement. Are annually prepared statements capable of indicating problems? Definitely, yes. Do yearly once due statements provide enough information? The answer must be no, as we are not living in a static economic environment. The more dynamic our economic environment is, the greater the role played by the question of time. Thanks to improvements in accounting and technology, we are able to create up-to-date analyses, based on accounting statements. However, in order to be effective, teamwork inside the company is essential and controllers should play a key role.

  15. Report on responsible growth. AREVA in 2008; Rapport de croissance responsable. AREVA en 2008

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    All over the world, AREVA supplies its customers with solutions for carbon-free power generation and electricity transmission and distribution. With its knowledge and expertise in these fields, the group has a leading role to play in meeting the world's energy needs. Ranked first in the global nuclear power industry, AREVA's unique integrated offering covers every stage of the fuel cycle, reactor design and construction, and related services. In addition, the group is expanding its operations in renewable energies. AREVA is also a world leader in electricity transmission and distribution and offers its customers a complete range of solutions for greater grid stability and energy efficiency. Sustainable development is a core component of the group's industrial strategy. Its 75,000 employees work every day to make AREVA a responsible industrial player that is helping to supply ever cleaner, safer and more economical energy to the greatest number of people. Sustainable development is a keystone of AREVA's industrial strategy for achieving growth that is profitable, socially responsible and respectful of the environment. To translate this choice into reality, AREVA integrates sustainable development into its management practices via a continuous improvement initiative revolving around ten commitments: customer satisfaction, financial performance, governance, community involvement, environmental protection, innovation, continuous improvement, commitment to employees, risk management and prevention, dialogue and consensus building. This document is Areva's 2008 report on responsible growth. After the Messages from the Chairman of the Supervisory Board and from the Chief Executive Officer, the report presents the Key data and Highlights of the period, the Corporate governance, the Organization of the group, the Share information and shareholder relations, the uranium reserves, the growing energy demand and the World's population demographic

  16. From the corporate social responsibility reporting to the integrated reporting: the case of Sabaf S.p.a

    OpenAIRE

    Renato Camodeca; Alex Almici

    2017-01-01

    In December 2013, the International Integrated Reporting Council (IIRC) published the International Integrated Reporting Framework. The aim of the Framework is to provide the guiding principles and the content elements of an integrated report. The integrated report constitutes an evolutionary step in the corporate’s financial and non-financial communication, moving from the social responsibility reporting to the integrated reporting. This practice is at the beginning in Europe and esp...

  17. Learner Response System: Evaluation Report and Executive Summary

    Science.gov (United States)

    Wiggins, Meg; Sawtell, Mary; Jerrim, John

    2017-01-01

    This Learner Response System (LRS) intervention involves the use of electronic handheld devices that allow teachers and pupils to provide immediate feedback during lessons. For example, pupils can respond to a question using the device and responses are immediately visible to the teacher, or they can work through problems on the device at their…

  18. Agency procedures for the NRC incident response plan. Final report

    International Nuclear Information System (INIS)

    1983-02-01

    The NRC Incident Response Plan, NUREG-0728/MC 0502 describes the functions of the NRC during an incident and the kinds of actions that comprise an NRC response. The NRC response plan will be activated in accordance with threshold criteria described in the plan for incidents occurring at nuclear reactors and fuel facilities involving materials licensees; during transportation of licensed material, and for threats against facilities or licensed material. In contrast to the general overview provided by the Plan, the purpose of these agency procedures is to delineate the manner in which each planned response function is performed; the criteria for making those response decisions which can be preplanned; and the information and other resources needed during a response. An inexperienced but qualified person should be able to perform functions assigned by the Plan and make necessary decisions, given the specified information, by becoming familiar with these procedures. This rule of thumb has been used to determine the amount of detail in which the agency procedures are described. These procedures form a foundation for the training of response personnel both in their normal working environment and during planned emergency exercises. These procedures also form a ready reference or reminder checklist for technical team members and managers during a response

  19. Second report on British nuclear weapons safety: a response to the Oxburgh report

    International Nuclear Information System (INIS)

    Plesch, D.; Ionno, S.J.; Brady, B.

    1992-01-01

    The Ministry of Defence's (MoD) report on nuclear weapons safety by Professor Sir Ronald Oxburgh fails to examine fundamental issues raised by the US Drell report concerning Trident, Chevaline and WE177. There has been a failure to make proper diagnosis, and where diagnosis has been made to offer appropriate treatment. Oxburgh states that he cannot give a definitive view on whether the Trident warhead meets the crucial ''one-point safety'' standard; that nuclear weapons are inherently hazardous; that they can produce accidental detonations and the release of plutonium; that contractorisation of Aldermaston may erode safety standards; that management must be improved; and that there is no complete record of nuclear accidents. This British American Security Information Council (BASIC) report asserts that the publicly available evidence indicates that all three British nuclear weapons could produce accidental nuclear detonations or the dispersal of plutonium as a result of fire or shock or both. Such accidents could occur, for example, during a road accident with a petrochemical truck, a submarine fire, a submarine loading accident or in an aircraft crash. Oxburgh states that WE177 and Chevaline are one-point safe, although it appears that the MoD have only used tests which Drell regarded as inferior and misleading. He also states that ''a major concern'' is the inability to be able to analyze the safety of the whole Trident system but no solution is offered. The Oxburgh report does not address the problem of fire when discussing the hazards associated with missiles and nuclear weapons. This was the central point of Drell's concerns about Trident. Oxburgh does not examine the problems and alternatives associated with the lack of safety features in the Trident warhead and its proximity to explosive fuel in the missile, nor did he examine the procedures for accident response even though these are of concern to many local authorities. (Author)

  20. Mandatory Corporate Social Responsibility Reporting in the EU

    DEFF Research Database (Denmark)

    Szabó, Dániel Gergely

    Although non-financial or CSR-reporting has attracted increasing attention in the last decades, it only recently entered the legal discourse. This book narrows the gap between CSR reporting and legal disclosure requirements. It analyses financial, management, and corporate governance reporting......, as well as other dedicated reporting types. The author investigates what legal framework underpins these disclosure types; to what extent these instruments mandate the disclosure of non-financial information; and if they have potential to expand their non-financial disclosure requirements. The findings...

  1. Corporate social responsibility report 2003. Sharing our energies

    International Nuclear Information System (INIS)

    2004-05-01

    This document assesses the results of the group Total initiatives in the domain of the corporate social responsibility, for the year 2003. It presents the society policy and actions concerning: the ethics as a foundation of broader corporate, the environment stewardship and the safety enhancement, the equity and diversity of the labor relations and human resources, the broader responsibility to society and communities, the financial performance and a group portrait. (A.L.B.)

  2. Sharing our energies. Corporate social responsibility report 2002

    International Nuclear Information System (INIS)

    2003-05-01

    This document assesses the results of the group Total initiatives in the domain of the corporate social responsibility, for the year 2002. It presents the society policy and actions concerning: the ethics as a foundation of broader corporate, the environment stewardship and the safety enhancement, the equity and diversity of the labor relations and human resources, the broader responsibility to society and communities, the financial performance and a group portrait. (A.L.B.)

  3. Immune response profiles after caterpillar exposure: a case report

    Directory of Open Access Journals (Sweden)

    Tamar A Smith-Norowitz

    2010-07-01

    Full Text Available Tamar A Smith-Norowitz1,3, Kevin B Norowitz1, Stephan Kohlhoff1,3, Kaushal Kalra1,3, Seto Chice2,3, Martin H Bluth41Departments of Pediatrics, 2Pathology, 3Center for Allergy and Asthma Research, SUNY Downstate Medical Center, NY, USA; 4Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USARationale: The role of the immune response to caterpillar exposure is not well described. This case study is the first to report a patient who presented with an allergic reaction after exposure to the larvae of the sycamore tussock moth, Halysidota harrisii Walsh, 1864.Methods: Blood was collected from an allergic asthmatic adult (m/42 y/o at 2 hrs – 2 wks after contact urticaria with associated dyspnea after exposure to the larvae of the sycamore tussock moth, Halysidota harrisii Walsh, 1864. Distributions of blood lymphocytes (CD4+, CD8+, CD8+CD60+, CD19+, CD23+, CD16/56+, CD25, CD45RA+, CD45RO+, monocytes (CD1d+, levels of serum immunoglobulins (IgM, IgG, IgA, IgE, and cytokines (IFN-γ, IL-4, TNF-a were studied (flow cytometry, nephelometry, UniCAP Total IgE Fluoroenzymeimmunoassay, cytokine ELISA, clinical toxicology.Results: Numbers of CD4+ T cells, CD25+ cells, CD19+ B cells, and CD1d+ monocytes decreased (22, 27, 33, 20%, respectively one week post reaction, CD45RA+ naïve T cells decreased at 36 hours (21%,while CD8+CD60+ T cells and CD23+ cells decreased 48 hrs (33, 74%, respectively post reaction. In contrast, numbers of CD16/56+ NK precursor cells increased (60% 12 hrs, then decreased (65% 48 hrs post reaction; other lymphocyte subsets were unaffected. Serum IgM, IgG and IgA were within normal range; however, serum IgE demonstrated a bimodal elevation at 2 hrs (15% and one week post reaction. Levels of IFN-γ, IL-4, and TNF-a were not detected in serum pre-exposure (<1.0–4.0 pg/mL. However, high levels of IFN-γ (187–319 pg/mL and TNF-a (549–749 pg/mL were detected in serum 24–36 hrs and 3.5–24 hrs post

  4. Responsive copolymers for enhanced petroleum recovery. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    This report describes the development of new synthetic polymers to be used in petroleum recovery. The solution behavior and rheology properties, as well as new techniques for measuring extensional flow behavior under controlled conditions in packed bed geometries is described.

  5. Corporate Social Responsibility Reporting: Differences among Selected EU Countries

    Directory of Open Access Journals (Sweden)

    Vukic Nikolina Markota

    2015-09-01

    Full Text Available Background: Greater transparency has become a relevant topic for companies around the world. Information and communication technologies revolution (ICT revolution has forced companies to become more transparent. With the intention of increasing companies’ transparency, the European Union (hereinafter: the EU has presented a new Accounting Directive 2013/34/EU which makes Corporate Social Reporting (hereinafter: CSR reporting mandatory for certain companies.

  6. Response to Intervention: Evaluation Report and Executive Summary

    Science.gov (United States)

    Gorard, Stephen; Siddiqui, Nadia; See, Beng Huat

    2014-01-01

    Response to Intervention (RTI) is a targeted programme that uses a tiered approach to identify the needs of low achieving pupils. The approach begins with whole class teaching (Tier 1), followed by small group tuition (Tier 2) for those who need more attention, and one to one tutoring (Tier 3) for those who do not respond to the small group…

  7. Peer Tutoring and Response Groups. What Works Clearinghouse Intervention Report

    Science.gov (United States)

    What Works Clearinghouse, 2007

    2007-01-01

    "Peer Tutoring and Response Groups" aims to improve the language and achievement of English language learners by pairing or grouping students to work on a task. The students may be grouped by age or ability (English-only, bilingual, or limited English proficient) or the groups may be mixed. Both peer tutoring pairs and peer response…

  8. Improved Estimation Procedures for Item Response Functions. Final Report on Project NR150-464. Research Report 84-2.

    Science.gov (United States)

    Tsutakawa, Robert K.

    This report describes new statistical procedures for item response analysis using estimation of item response curves used in mental testing with ability parameters treated as a random sample. Modern computer technology and the EM algorithm make this solution possible. The research focused on the theoretical formulation and solution of maximum…

  9. Responsible Development of Areva's Mining Activities. 2010 report

    International Nuclear Information System (INIS)

    2010-01-01

    After a map indicating the location of the main Areva's mining sites, this report provides several key figures and data and discusses the evolution of this activity which is part of the business core of the AREVA company. It gives a statement of values and principles, governance and commitments related to this activity. In order to report this activity, it addresses several topics: reduction of industrial risks, protection of workers and populations, rational consumption of water and energy resources, biodiversity preservation, management over time of waste rock and mining tailings, sustainable integration into territories, and contribution to social development. This document is proposed in French and in English

  10. REPORTING OF CORPORATE SOCIAL RESPONSIBILITY IN SMES SECTOR IN POLAND

    Directory of Open Access Journals (Sweden)

    B. Kotowska

    2016-04-01

    Full Text Available In Poland and worldwide, corporate social responsibility has a growing interest of managers, business institutions, investors and the government. Thus, it becomes progressively determinant of corporate governance and priority in building a comprehensive development strategy. CSR is used by large companies. However, this does not mean that SMEs sector companies operate less responsible than large one. Each enterprise, regardless of size, operates in a specific social surroundings and market environment, which are affected by different groups of stakeholders. They may affect enterprise reinforcing effect on - contribute to its success or failure. It is therefore important that the managers should be able to identify social groups in the enterprise and its environment and respect their claims, needs, rights and expectations. The aim of this paper is to show the application of CSR by micro, small and medium-sized enterprises in Poland and the manner of result presentation. This article lists tools of corporate social responsibility, examples of practices and research results in the SMEs sector in Poland.

  11. Survey of system responsibility in the Nordic countries. Final report

    International Nuclear Information System (INIS)

    2005-02-01

    In September 2004 the Nordic Council of Ministers asked Nordel to perform some tasks and present the results to the Council on 1 March 2005. One of the tasks is to survey how system responsibility is defined and executed in the different Nordic countries. According to the Nordic Council of Ministers, the survey shall illuminate similarities and differences between the countries and assess the reasons for the differences. Nordel is asked to present a joint view system responsibility in the Nordic countries. Among other things, the responsibility for the system operators and the participants in the market shall be defined. The definition shall also include the distribution of costs between costs for network business and costs for business in competition. This shall be done in a way that creates a common platform for the further harmonisation work and continuous positive development of the Nordic electricity market. It is also important to identify the need for changes in e.g. legislation and guidelines in the different countries as a consequence of an implementation of a common definition in the Nordic countries. Areas to be included in the task are among others, balance settlement, security of supply, congestion management and system services. (BA)

  12. PROMIS® Parent Proxy Report Scales: an item response theory analysis of the parent proxy report item banks.

    Science.gov (United States)

    Varni, James W; Thissen, David; Stucky, Brian D; Liu, Yang; Gorder, Hally; Irwin, Debra E; DeWitt, Esi Morgan; Lai, Jin-Shei; Amtmann, Dagmar; DeWalt, Darren A

    2012-09-01

    The objective of the present study is to describe the item response theory (IRT) analysis of the National Institutes of Health (NIH) Patient Reported Outcomes Measurement Information System (PROMIS(®)) pediatric parent proxy-report item banks and the measurement properties of the new PROMIS(®) Parent Proxy Report Scales for ages 8-17 years. Parent proxy-report items were written to parallel the pediatric self-report items. Test forms containing the items were completed by 1,548 parent-child pairs. CCFA and IRT analyses of scale dimensionality and item local dependence, and IRT analyses of differential item functioning were conducted. Parent proxy-report item banks were developed and IRT parameters are provided. The recommended unidimensional short forms for the PROMIS(®) Parent Proxy Report Scales are item sets that are subsets of the pediatric self-report short forms, setting aside items for which parent responses exhibit local dependence. Parent proxy-report demonstrated moderate to low agreement with pediatric self-report. The study provides initial calibrations of the PROMIS(®) parent proxy-report item banks and the creation of the PROMIS(®) Parent Proxy-Report Scales. It is anticipated that these new scales will have application for pediatric populations in which pediatric self-report is not feasible.

  13. 14 CFR 1274.933 - Summary of recipient reporting responsibilities.

    Science.gov (United States)

    2010-01-01

    ....913 Patent Rights—Retention by the Recipient (Small Business)(Paragraph (h)) Notice of Proposed... Reportable Items Every 12 months 1274.912 Patent Rights—Retention by the Recipient (Large Business)(Paragraph...—Retention by the Recipient (Large Business) (Paragraph (e)(3)(ii)) Disclosure of Subject Inventions Within 2...

  14. 34 CFR 611.50 - What are a grantee's reporting responsibilities?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What are a grantee's reporting responsibilities? 611.50....50 What are a grantee's reporting responsibilities? (a) Within 30 days of the beginning of the teacher preparation program's academic term or within 30 days of the execution of any scholarship...

  15. Aviation System Analysis Capability Quick Response System Report

    Science.gov (United States)

    Roberts, Eileen; Villani, James A.; Ritter, Paul

    1998-01-01

    The purpose of this document is to present the additions and modifications made to the Aviation System Analysis Capability (ASAC) Quick Response System (QRS) in FY 1997 in support of the ASAC ORS development effort. This document contains an overview of the project background and scope and defines the QRS. The document also presents an overview of the Logistics Management Institute (LMI) facility that supports the QRS, and it includes a summary of the planned additions to the QRS in FY 1998. The document has five appendices.

  16. A new emergency response model for MACCS. Final report

    International Nuclear Information System (INIS)

    Chanin, D.I.

    1992-01-01

    Under DOE sponsorship, as directed by the Los Alamos National Laboratory (LANL), the MACCS code (version 1.5.11.1) [Ch92] was modified to implement a series of improvements in its modeling of emergency response actions. The purpose of this effort has been to aid the Westinghouse Savannah River Company (WSRC) in its performance of the Level III analysis for the Savannah River Site (SRS) probabilistic risk analysis (PRA) of K Reactor [Wo90]. To ensure its usefulness to WSRC, and facilitate the new model's eventual merger with other MACCS enhancements, close cooperation with WSRC and the MACCS development team at Sandia National Laboratories (SNL) was maintained throughout the project. These improvements are intended to allow a greater degree of flexibility in modeling the mitigative actions of evacuation and sheltering. The emergency response model in MACCS version 1.5.11.1 was developed to support NRC analyses of consequences from severe accidents at commercial nuclear power plants. The NRC code imposes unnecessary constraints on DOE safety analyses, particularly for consequences to onsite worker populations, and it has therefore been revamped. The changes to the code have been implemented in a manner that preserves previous modeling capabilities and therefore prior analyses can be repeated with the new code

  17. Responsible Reporting : Neuroimaging News in the Age of Responsible Research and Innovation

    NARCIS (Netherlands)

    de Jong, Irja Marije; Arentshorst, Marlous; Broerse, Jacqueline; Kupper, J.F.H.

    Besides offering opportunities in both clinical and non-clinical domains, the application of novel neuroimaging technologies raises pressing dilemmas. 'Responsible Research and Innovation' (RRI) aims to stimulate research and innovation activities that take ethical and social considerations into

  18. Restless legs syndrome responsive to rasagiline treatment: a case report.

    Science.gov (United States)

    Babacan-Yildiz, Gulsen; Gursoy, Esra; Kolukisa, Mehmet; Celebi, Arif

    2012-01-01

    We describe a patient with idiopathic restless legs syndrome (iRLS) who was responsive to rasagiline treatment. A 70-year-old woman presented with an 8-year history of iRLS symptoms and a 1-year history of resting tremor. The patient met the UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria (UK Parkinson Disease [PD] Brain Bank criteria) for the diagnosis of idiopathic PD and the criteria of the International Restless Legs Syndrome Study Group for the diagnosis of iRLS. One milligram of rasagiline once daily was started with the diagnosis of early PD as monotherapy. At week 8, the patient was almost iRLS symptoms free. Rasagiline has also been shown to mildly improve PD symptoms. Rasagiline was well tolerated during the follow-up. We suggest that rasagiline could represent a useful therapeutic option in the treatment of iRLS.

  19. Final Report: Proteomic study of brassinosteroid responses in Arabidopsis

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhiyong [Carnegie Inst. of Washington, Argonne, IL (United States); Burlingame, Alma [Univ. of California, San Francisco, CA (United States)

    2017-11-29

    The steroid hormone brassinosteroid (BR) is a major growth-promoting phytohormone. The specific aim of the current project is to identify BR-regulated proteins and characterize their functions in various aspects of plant growth, development, and adaptation. Our research has significantly advanced our understanding of how BR signal is transduced from the receptor at the cell surface to changes of nuclear gene expression and other cellular responses such as vesicle trafficking, as well as developmental transitions such as seed germination and flowering. We have also developed effective proteomic methods for quantitative analysis of protein phosphorylation and for identification of glycosylated proteins. Through this DOE funding, we have performed several proteomic experiments and made major discoveries.

  20. Report of the written responses on National Energy Policy

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-05-01

    A Public Notice appeared in the March 2, 1977 edition of The Federal Register inviting the American people to comment on and make recommendations for the President's National Energy Policy. The Notice, signed by James R. Schlesinger, sought comment on eight broad areas of policy; but it also encouraged citizens to address the issues that most concerned them and to do so in their own style. The eight broad areas of energy policy are: conservation, imported energy, supply development, environment, Federal regulation, intergovernmental relations, citizen participation, and hardships. By April 1, 27,898 letters, telegrams, packages, mailgrams, and position papers had been received, 18,721 of these from the general public. Every letter was carefully read and reviewed. The policy issues mentioned in the Public Notice are listed with tables and brief descriptions of the responses. The tables also indicate consensus or the lack of it. (ERA citation 04:036682)

  1. Talisman Energy Inc : corporate social responsibility report 2000 : Sudan operations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-04-01

    Talisman Energy Inc., the largest independent Canadian oil and gas producer with operations worldwide, owns a subsidiary Talisman (Greater Nile) B.V., which is in turn a 25 per cent owner in the Greater Nile Petroleum Operating Company (GNPOC) whose share of oil production accounted for 11 per cent of Talisman's worldwide production in 2000. GNPOC operates three exploration and two development blocks encompassing 12,200,000 acres of land in Sudan. Production began in 1999 and is currently at 200,000 barrels per day. This report describes Talisman Energy's operations in Sudan and measures compliance with the International Code of Ethics for Canadian Business that Talisman adopted in December 1999. The report evaluates Talisman's progress towards achieving objectives in the areas of human rights, community participation, employee rights, ethical business conduct, health, safety and the environment. In addition, Talisman will continue to advocate peace and the fair distribution of oil revenues. Talisman's community development initiatives include the provision of water wells, health clinics and schools in Sudan. tabs., figs.

  2. Drivers of corporate social responsibility reporting; Case studies from three reporting companies

    Directory of Open Access Journals (Sweden)

    Daniel Tschopp PhD, MBA, CPA

    2013-07-01

    Past research cited several reasons companies issued reports, but it does not tell the whole story. These three individual case studies demonstrate the importance of the primary determinant behind an organization’s decision to issue a CSR report. This finding can provide valuable information for further studies that deal with the promotion, diffusion, and harmonization of CSR reporting.

  3. N-Springs expedited response action performance evaluation report

    International Nuclear Information System (INIS)

    Mukherjee, B.B.

    1996-07-01

    Groundwater in the 100-NR-2 Operable Unit (OU) has been contaminated with various radionuclides, metals, and ionic constituents because of waste water disposal practices and spills associated with I 00-N Reactor operations. Of primary concern are the presence of high levels of strontium-90 in the groundwater and the discharge of 90 Sr contaminated groundwater to the nearby Columbia River through historic river bank seeps known as 'N-Springs'. In accordance with the requirements of the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement), remediation alternatives are currently being evaluated to address the hazardous substances and constituents in the soil and groundwater at the 100-NR-1/100-NR-2 OUs. Because of concern regarding the release of 90 Sr to the river, the Washington State Department of Ecology (Ecology) and the US Environmental Protection Agency (EPA) issued an action memorandum on September 23, 1994, to the U.S. Department of Energy (DOE), Richland Operations Office (RL), to take immediate actions consisting of a combination of a groundwater pump-and-treat system and a sheet pile barrier wall at N-Springs. By letter, dated March 23, 1995, Ecology and EPA agreed that a sheet pile construction test in December 1994 showed that the installation of the jointed hinge sheet pile wall could not be achieved in the manner specified. Ecology and EPA directed RL to proceed with the installation of the Expedited Response Action (ERA) pump-and-treat system and to (1) continue assessing accurately the flux of strontium to the river, (2) further characterize geologic and hydrologic conditions, and (3) assess design and installation alternatives related to modified barriers and expected performance

  4. Molecular events basic to cellular radiation response. Progress report

    International Nuclear Information System (INIS)

    Kolodny, G.M.

    1974-01-01

    Work during the past year has been focused on three areas related to the cellular effects of radiation. Radiation effects on RNA and the regulation of gene expression and amino acid-nucleic acid interactions were studied. Studies on the radiation response of RNA in growing and confluent cells were continued. We have derived radiation survival curves and demonstrated repair of potentially lethal damage in 3T3 cells. Studies of giant cell formation and turnover of ribosomal RNA in irradiated cells has demonstrated differences in growing and confluent cells. We have sought evidence consistent with our hypothesis for regulation of eukaryotic gene expression with segments of RNA reutilized to prime new RNA synthesis. Data derived from the turnover of ribosomal RNA and the methylation pattern of ribosomal RNA during turnover are consistent with the possibility that a segment of 18s ribosomal RNA is being conserved during new RNA synthesis. We were unable to show reutilization of the 5' trinucleotide of 18s and 28s ribosomal RNA but did find a ribonuclease resistant oligonucleotide in 18s RNA which appeared to be reutilized. In studies of amino acid nucleic-acid interactions using nuclear magnetic resonance spectroscopy we have been able to successfully synthesize an amidate and begin an examination of the intramolecular interactions. We have also studied intermolecular interactions betweentryptophan and nucleoside monophosphates and found upfield shifts which provide evidence for preferential stacking of the 6-membered ring of tryptophan with adenine and evidence for specific geometry of interactions of tryptophan with cytosine. (U.S.)

  5. Assessing the quality of corporate social responsibility reports: the case of reporting practices in selected European Union member states.

    Science.gov (United States)

    Hąbek, Patrycja; Wolniak, Radosław

    The organization may communicate its engagement in sustainability and may presents results achieved in this field by creating and publishing corporate social responsibility (CSR) reports. Today, we can observe a growing number of companies issuing such reports as a part of their annual reports or as stand-alone CSR reports. Despite the increase in the number of such reports their quality is different. CSR reports do not always provide complete data that readers desire, which in turn intensifies the problem with the evaluation and comparison of the organization's results achieved in this scope. Differences also occur between reporting models used in different EU countries caused by, inter alia, differently applied EU legislation on the disclosure of non-financial information in different Member States. This paper is one of the first attempts to perform a quantitative and qualitative analysis of corporate sustainability reporting practices in several European Union countries. The purpose of this article is to present the current state of CSR reporting practices in selected EU Member States and identify the differences in the quality and level of this kind of practices, taking into account the mandatory and voluntary model of disclosure. The study included separate CSR reports as well as annual reports with CSR sections and integrated reports published in 2012 in six selected EU Member States. The authors have used a specific evaluation tool in the examination of the individual reports. The assessment questionnaire consists of seventeen criteria grouped into two categories (relevance and credibility of information). In order to assess the quality of examined reports, the authors aggregated the indicators related with the reporting practices. The findings show that the quality level of the studied reports is generally low. Referring to its components, the relevance of the information provided in the assessed reports is at the higher level than its credibility. The

  6. Corporate Social Responsibility in Malaysian Apparel Manufacturing Industry: A Study on Corporate Social Responsibility Website Reporting

    OpenAIRE

    Ramakrishnan, Suresh; Hishan, Sanil S.; Kanjanapathy, Malini

    2016-01-01

    ABSTRACT:A well planned and implemented Corporate Social Responsibility (CSR) programs could give any company a competitive advantage over its competitors. However, the way it is communicated to its stakeholders will be one of the deciding factors. This study examines how the WRAP certified apparel manufacturers in Malaysia communicate their CSR programs on their company website. This study identifies the dimensions of CSR they focus while they communicate their CSR initiatives to their stake...

  7. Response to Environmental Policy Institute report on Savannah River Plant high-level waste management

    International Nuclear Information System (INIS)

    1986-01-01

    In a recently published report entitled ''Deadly Crop in the Tank Farm,'' the Environmental Policy Institute (EPI) presented its opinions on the hazards associated with waste management practices at SRP. The EPI's allegations were based on selected published Department of Energy and Du Pont reports and on raw data from the unpublished 200-Area Fault Tree Data Bank that it obtained in 1983. Professional staff at SRP have reviewed the report in detail and have provided responses in this document to all significant EPI statements and recommendations. The responses are grouped into five major categories: Waste Management Operations -- Past and Present, Accidents and Risks, Worker Exposure and Cancer Epidemiology, Groundwater Contamination, and Long-Term Waste Management. An overview of the responses is provided in the Summary, and the detailed responses are presented in the body of the report. 55 refs., 1 fig., 1 tab

  8. Shaping corporate social responsibility management and reporting through engagement : The role of advocacy organisations

    NARCIS (Netherlands)

    Clune, C.

    2017-01-01

    Advocacy organisations have traditionally played a prominent role in shaping corporate social responsibility (CSR) management and reporting practices through organisational-level and institutional-level engagement. Recent years have seen advocacy organisations expand the nature and content of their

  9. Report: Information Security Series: Security Practices Comprehensive Environmental Response, Compensation, and Liability Information System

    Science.gov (United States)

    Report #2006-P-00019, March 28, 2006. OSWER’s implemented practices to ensure production servers were being monitored for known vulnerabilities and personnel with significant security responsibility completed the Agency’s recommended security training.

  10. Practices of corporate social responsibility and sustainable systems work in Peruvian companies issuing sustainability reports

    OpenAIRE

    Prialé, María Angela; Fuchs, Rosa María; Sáenz, Manuel

    2014-01-01

    Through a literature review, this exploratory study seeks to determine whether the practices related to its colaborators, who report as part of its action responsible Peruvian companies issuing sustainability reports can be considered sustainable management practices of human resources. To this end, it was used the approach of sustainable work systems as a general approach. It was found that some of the practices of responsible management of human resources that implement the analyzed compani...

  11. Does response distortion statistically affect the relations between self-report psychopathy measures and external criteria?

    NARCIS (Netherlands)

    Watts, A.L.; Lilienfeld, S.O.; Edens, J.F.; Douglas, K.S.; Skeem, J.L.; Verschuere, B.; LoPilato, A.C.

    2016-01-01

    Given that psychopathy is associated with narcissism, lack of insight, and pathological lying, the assumption that the validity of self-report psychopathy measures is compromised by response distortion has been widespread. We examined the statistical effects (moderation, suppression) of response

  12. Radioactive waste: the Nuclear Industry's response to the Environment Committee's report

    International Nuclear Information System (INIS)

    1986-07-01

    This paper represents the nuclear industry's response to the Environmental Committee's report on the handling and disposal of radioactive wastes. Topics covered include the historical aspects of the management of radioactive wastes, technical problems, comparisons with overseas management methods, liquid effluents, reprocessing problems, and public attitudes and perceptions of radioactive waste. Responses to the Environmental Committee's recommendations form an appendix. (U.K.)

  13. Responsibility-based A/R reporting: how one health system drove performance with analytics.

    Science.gov (United States)

    Powell, Lisa; Hindman, Ashley; McMillan, Brett

    2009-09-01

    An automated accounts receivable (A/R) reporting package should provide managers with data-driven information to help them respond to emerging trends in the revenue cycle. Responsibility for clearly defined account portfolios should be assigned to managers, and targets should be established. This data-driven approach with its culture of responsibility can help healthcare organizations reach their A/R goals.

  14. Response sets in self-report data and their associations with personality traits

    NARCIS (Netherlands)

    de Jonge, P; Slaets, JPJ

    2005-01-01

    Objective: With a strong reliance on the use of self-report questionnaires in psychiatric research, appropriate attention should he given to the existence and correlates of response sets. We studied the presence of response tendencies by using an old research paradigm from psychology. Methods: We

  15. Gynephilic Men's Self-Reported and Genital Sexual Responses to Relationship Context Cues.

    Science.gov (United States)

    Timmers, Amanda D; Chivers, Meredith L

    2018-04-01

    The current study examined men's sexual responses to relationship context. Chivers and Timmers (2012) previously reported that heterosexual men's genital and self-reported sexual arousal varied by gender but not relationship context, suggesting that gender cues are more salient determinants of sexual response than relationship context cues for men. Those analyses were, however, significantly underpowered to detect relationship context effects (n = 9). The current study utilized the same paradigm as Chivers and Timmers' study, exposing a larger sample of heterosexual men (n = 26) to audio narratives describing sexual interactions that varied by partner gender (man, woman) and relationship context (stranger, friend, long-term relationship), and observing effects on genital and self-reported sexual response. Results indicated that men's genital response to relationship context cues mirrored those previously reported for heterosexual women (Chivers & Timmers, 2012); heterosexual men demonstrated less genital response to the friend than to the stranger or long-term relationship conditions. No significant effect of relationship context was found for men's self-reported sexual arousal. These data suggest that, in addition to gender cues, relationship cues may also be an important determinant of men's genital sexual responses.

  16. Information disclosure in corporate social responsibility reports. The case of Lithuanian companies

    Directory of Open Access Journals (Sweden)

    Sviesa Leitoniene

    2016-09-01

    Full Text Available Though the phenomenon of corporate social responsibility (CSR is closely scrutinized in studies of both Lithuanian and foreign scholars, the problem is the quality of social information disclosed in social re-sponsibility reports. The objective of this article is to analyse the quality of disclosed information in CRS reports of Lithuanian companies. The characteristics of quality of information were comparability, relia-bility, objectivity and sustainability. The research demonstrated that in Lithuania, CSR reports provide unreliable information, which is only partly comparable and objective, however, relatively sustainable.

  17. Aviation System Analysis Capability Quick Response System Report Server User's Guide

    Science.gov (United States)

    Roberts, Eileen R.; Villani, James A.; Wingrove, Earl R., III

    1996-01-01

    This report is a user's guide for the Aviation System Analysis Capability Quick Response System (ASAC QRS) Report Server. The ASAC QRS is an automated online capability to access selected ASAC models and data repositories. It supports analysis by the aviation community. This system was designed by the Logistics Management Institute for the NASA Ames Research Center. The ASAC QRS Report Server allows users to obtain information stored in the ASAC Data Repositories.

  18. HTGR accident initiation and progression analysis status report. Volume VIII. Responses to comments on AIPA status report

    Energy Technology Data Exchange (ETDEWEB)

    Raabe, P.H.

    1977-01-01

    The first seven volumes of the report series provide formal documentation of the status of the ERDA-sponsored Accident Initiation and Progression Analysis (AIPA) study as of the end of FY75. That portion of the report was given broad distribution to government agencies, industrial organizations, and academic institutions. Comments on the Status Report have been actively solicited from these and other organizations. The volume presented (the eighth in the AIPA Status Report) documents all of the formal written comments that have been received as of September 30, 1976, together with the responses to those comments. The comments as presented are direct quotations from the manuscripts as submitted by the reviewers; none have been paraphrased. The comments are presented in the same order as submitted by the reviewers and are generally addressed individually.

  19. Displaying Wages as an Indicator of the Social Responsibility of Business in Accounting and Reporting

    Directory of Open Access Journals (Sweden)

    Katkova Natalia V.

    2017-12-01

    Full Text Available The article is concerned with displaying wages in both accounting and reporting, in the context of social responsibility. The basic approaches to definition of social responsibility in the context of relations of employers and employees were considered. It was noted that an effective means of implementing the conception of social responsibility would be the preparation of integrated reporting, and for this purpose the elements of social responsibility of enterprises should be reflected in the accounting system. It is expedient to include in the indicators of social responsibility of the integrated reporting of enterprises the level of remuneration of the current character; the amount of compensation payments in connection with the completion of work and due to difficult working conditions, harmful industries; the amount of incentive payments as a result of developing the skill level and increasing labor efficiency; payments on the sectoral individual pensions and on social support programs, etc. The displaying of the proposed indicators in the reporting of enterprise would provide disclosure of information on the implementation of the principles of social responsibility and would inform the interested parties about the implementation of social programs and projects at the enterprise.

  20. Health complaints and wind turbines: The efficacy of explaining the nocebo response to reduce symptom reporting.

    Science.gov (United States)

    Crichton, Fiona; Petrie, Keith J

    2015-07-01

    A number of people are reporting an environmental sensitivity to sub-audible windfarm sound (infrasound), characterised by the experience of recurrent non-specific symptoms. A causal link between exposure and symptoms is not indicated by empirical evidence. Research indicates symptoms may be explained by the nocebo response, whereby health concerns and negative expectations, created from social discourse and media reports, trigger symptom reporting. The experimental aim was to test whether providing a nocebo explanation for symptoms, to individuals reporting symptomatic experiences during infrasound exposure, would ameliorate symptoms during further exposure. Sixty-six volunteers were randomly assigned to nocebo explanation or biological explanation groups. Participants were concurrently exposed to infrasound and audible windfarm sound, while reporting on current symptoms and mood, during two exposure sessions. Preceding session one, participants watched a presentation integrating media warnings about purported health risks posed by windfarm infrasound. Before session two, nocebo explanation participants viewed material outlining how nocebo responding could explain symptom reporting. Instead biological explanation participants watched material presenting pathophysiological theories for symptoms. During session one, participants reported increased symptoms and mood deterioration from baseline assessment. During session two symptom reporting and mood deterioration was maintained by biological explanation participants, while mood and symptoms reported by nocebo explanation participants returned to baseline levels. Results indicate that providing an explanation of the nocebo response, followed by exposure to infrasound, has the potential to operate as an intervention to reduce symptomatic experiences in people reporting symptoms attributed to windfarm generated infrasound. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. Prescriber response to unsolicited prescription drug monitoring program reports in Massachusetts.

    Science.gov (United States)

    Thomas, Cindy Parks; Kim, Meelee; Nikitin, Ruslan V; Kreiner, Peter; Clark, Thomas W; Carrow, Grant M

    2014-09-01

    To describe prescriber response to unsolicited patient reports from the Massachusetts prescription drug monitoring program (PDMP). Prescribers were surveyed upon receipt of unsolicited reports of their patients' prescription history and three months later. We assessed prescribers' awareness of other prescribers listed in the report, their clinical assessment of medical necessity of all prescribed medications, actions taken by prescribers after receiving the report, and usefulness of the report. Of the 333 respondents to the initial survey, only 28 (8.4%) were aware of most, all, or nearly all other prescribers. A total of 146 (43.8%) reported having sufficient knowledge to determine whether the prescriptions were medically necessary, of whom 102 (69.6%) felt the prescriptions were unwarranted. Of the 163 respondents to the follow-up survey, 31.3% added the report to the patient's file, 22.7% discussed the report with other prescribers on the report, 21.5% took no action, and 6% discussed the report with the patient (representing two-thirds of respondents who saw the patient after receiving the report). Most respondents felt that the report was useful for their practice and easy to understand. Unsolicited reporting of PDMP data has the potential to improve clinical practice by alerting providers about patients with multiple prescribers and potentially medically unnecessary prescriptions. Copyright © 2014 John Wiley & Sons, Ltd.

  2. Adult non-response bias from a child perspective. Using child reports to estimate father's non-response.

    Science.gov (United States)

    Bastaits, Kim; Pasteels, Inge; Ponnet, Koen; Mortelmans, Dimitri

    2015-01-01

    Most parenting research on paternal involvement uses data from a father perspective. Nevertheless, research on bias in father non-response is scarce. In this study, we examine the non-response bias of fathers, hypothesizing that fathers who engage in parenting studies might already be fathers who are more involved with their children than fathers who do not engage in these studies. Furthermore, we expect a double non-response bias by socio-demographic characteristics of the father, which impacts both paternal participation as well as paternal involvement. Using the multi-actor dataset from the "Divorce in Flanders"-project, which provides data from children whose fathers actually participated (N=461) as well as data from children whose fathers did not (N=137) with children reporting on paternal involvement, we are able to test our hypotheses. Results confirm our first hypothesis, indicating that non-participating fathers are significantly more uninvolved than participating fathers. Regarding our second hypothesis, an indirect effect of father's educational level and age on non-response was revealed for one out of three indicators of paternal involvement. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. IRSN - Institute of Radiation protection and Nuclear Safety. Report 2014. Corporate societal responsibility

    International Nuclear Information System (INIS)

    Repussard, Jacques; Dufer, Bruno

    2015-06-01

    After a discussion of the importance of the societal responsibility of the IRSN as a collective approach, and as an asset for nuclear safety, this report first addresses how to preserve the environment and to manage the risks (reduction of carbon print in the policy of trips and travels, improvement of energy efficiency of IRSN buildings). It describes how to maintain the social commitment at a high level, how to develop responsible purchases and sales, how to strengthen relationships between stakeholders

  4. Market efficiency of traditional stock market indices and social responsible indices: the role of sustainability reporting

    OpenAIRE

    Henry Mynhardt; Inna Makarenko; Alex Plastun

    2017-01-01

    Corporate social responsibility, disclosed in sustainability reporting, influences the financial performance of companies. As a result, traditional stock market indices (TI) are expanded with the social responsible stock market indices (SRI). The aim of this study was to establish whether there are any differences in the behavior of the TI and SRI. To do this, the authors analyzed their efficiency. They used R/S analysis to calculate the Hurst exponent as a measure of persistence (long-term m...

  5. Corporate social responsibility reporting by the National Forest Holding „State Forests”

    Directory of Open Access Journals (Sweden)

    Ewa Śnieżek

    2016-09-01

    Full Text Available Today, the company, in addition to meeting its economic goals, should be involved in the implementation of the concept of corporate social responsibility. State Forests is not an exception in this respect, on the contrary – its existence, by definition, has dictated inscribing in the mission, vision and strategy of this company a responsibility to society, both to present and future generations. To date, State Forests has not developed a uniform framework for reporting socially responsible activities. Despite the many scattered documents indicating their contribution in this regard, State Forests has not included in its report a set of information on these issues. The aim of the article is to point out that social responsibility in such an entity as State Forests National Forest Holding is an extremely important area having long-term conse-quences for the contemporary and future generations. The article demonstrates the need for corporate social responsibility accounting and proposes a general structure of a report on social responsibility of State Forests for the current and future stakeholders. As a primary method of research, in addition to literature studies, the deductive method was used, assisted with reasoning by analogy.

  6. Practices of corporate social responsibility and sustainable systems work in Peruvian companies issuing sustainability reports

    Directory of Open Access Journals (Sweden)

    María Angela Prialé

    2015-12-01

    Full Text Available Through a literature review, this exploratory study seeks to determine whether the practices related to its colaborators, who report as part of its action responsible Peruvian companies issuing sustainability reports can be considered sustainable management practices of human resources. To this end, it was used the approach of sustainable work systems as a general approach. It was found that some of the practices of responsible management of human resources that implement the analyzed companies address the human dimensions of sustainability, although not all dimensions are considered equally or similar depth.

  7. Relationship between Achievement Goals and Students' Self-Reported Personal and Social Responsibility Behaviors.

    Science.gov (United States)

    Agbuga, Bulent; Xiang, Ping; McBride, Ron E

    2015-04-21

    This study utilized the 2x2 achievement goal model (mastery-approach, mastery-avoidance, performance-approach, performance-avoidance goals) to explore the relationships between achievement goals and self-reported personal and social responsibility behaviors in high school physical education settings. Two hundred and twenty one Turkish students completed questionnaires assessing their achievement goals, personal and social responsibility behaviors. Results of the one-way repeated measures ANOVA revealed significant differences among the four achievement goals, F(3, 660) = 137.05, p social responsibility (r = .38, p responsibility behaviors, and b = .41, t(216) = 5.23, p social responsibility behaviors. These findings seem to provide convergent evidence that mastery-approach goals are positively related to positive educational outcomes.

  8. ANDRA - National Radioactive Waste Management Agency. 2014 Activity report - Responsibility in action. Financial report 2014

    International Nuclear Information System (INIS)

    2015-01-01

    Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity and financial report of the Andra for the year 2014

  9. Corporate Social Responsibility Reporting in the Enlarged European Union: An Eleven Country Study

    OpenAIRE

    Owens, Graham John

    2003-01-01

    The aim of this research project is to study corporate social responsibility (CSR) reporting from organisations whose base country is in one of eleven countries in the proposed enlarged European Union (EU). Five of the countries awaiting formal entry to the EU, namely the Czech Republic, Hungary, Lithuania, Poland and Slovenia, whilst the other six have been members for a number of years, the United Kingdom, France, Germany, Ireland, Spain and Portugal. The paper investigates the reporting of...

  10. A dramatic, objective antiandrogen withdrawal response: case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Litwin Alan

    2008-11-01

    Full Text Available Abstract Antiandrogen withdrawal response is an increasingly recognized entity in patients with metastatic prostate cancer. To our knowledge, there have been no reports describing a durable radiologic improvement along with prostate-specific antigen (PSA with discontinuation of the antiandrogen agent bicalutamide. We report a case in which a dramatic decline of serum PSA levels associated with a dramatic improvement in radiologic disease was achieved with bicalutamide discontinuation.

  11. The effect of mandatory regulation on corporate social responsibility reporting quality: evidence from China

    OpenAIRE

    Wang, Jianling; Tian, Gaoliang; Fan, Weiguo; Luo, Dan

    2017-01-01

    Corporate Social Responsibility (CSR) disclosure has attracted attention from regulatory bodies and academics over the past few decades. Due to the unreliability resulted from CSR voluntary disclosure, an increasing number of researchers are calling for more government regulation on CSR disclosure. Based on 1830 standalone CSR reports disclosed by the Chinese-listed firms during 2009-2012, we examine the effect of mandatory regulation on CSR\\ud reporting quality. We further hypothesize and te...

  12. Corporate Social Responsibility Reporting – a Stakeholder’s Perspective Approach

    Directory of Open Access Journals (Sweden)

    Litfin Thorsten

    2017-03-01

    Full Text Available Background: International financial reporting standards have constantly been facing fast-growing significant development. This has mainly been driven by the aim of better serving the needs of the investors. Awareness that corporate financial reporting provides short-sighted information and measures has been rising among politicians, in the society and on the financial markets. Therefore, Corporate Social Responsibility (CSR reporting as a form of non-financial reporting has made it to limelight. Various reporting types developed, but the type of reporting is hardly codified. Objective: The goal of this paper is to identify the superior CSR reporting type from a stakeholder’s perspective. After identifying and analyzing central guidelines on CSR reporting and presenting different approaches, the authors will apply a positive-empirical methodology. Methods/Approach: In this first innovative joint attempt, eye-tracking technology is combined with a questionnaire for approaching CSR quality. Results: This study demonstrates the validity of the used methodology for the analysis of search and information browsing behavior in various types of sustainability reports. Conclusions: Overall our findings indicate that the reporting type "reference sustainability report" may not be advisable from a stakeholder’s perspective.

  13. Work Scope for Developing Standards for Emergency Preparedness and Response: Fiscal Year 2004 Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Stenner, Robert D.

    2005-09-28

    Summarizes the fiscal year 2004 work completed on PNNL's Department of Homeland Security Emergency Preparedness and Response Standards Development Project. Also, the report includes key draft standards, in various stages of development and publication, that were associated with various tasks of the fiscal year 2004 scope of the project.

  14. Eosinophilic Panniculitis with Full Response to Dapsone Therapy: A Case Report

    Directory of Open Access Journals (Sweden)

    Ekrem Aktaş

    2010-12-01

    Full Text Available Eosinophilic panniculitis is characterized by a mixed type inflammatory cell infiltration, predominantly with eosinophils, in subcutaneous tissue. Gnathostomiasis (Larva migrans profondus, leucocytoclastic vasculitis and erythema nodosum are implicated as the most common etiologic causes. In this case report, we present an idiopathic eosinophilic panniculitis with full response to Dapsone therapy, which had not responded to corticosteroids, and literature data were reviewed.

  15. Discrepancy between echocardiographic and patient-reported health status response to cardiac resynchronization therapy

    DEFF Research Database (Denmark)

    Versteeg, Henneke; van 't Sant, Jetske; Cramer, Maarten J

    2014-01-01

    The current study examined the degree of agreement between echocardiographic and patient-reported health status response to CRT 6 months after implantation, and evaluated the differences in pre-implantation characteristics of patients with concordant and discordant echocardiographic and health st...

  16. Experience Report: Constraint-Based Modelling and Simulation of Railway Emergency Response Plans

    DEFF Research Database (Denmark)

    Debois, Søren; Hildebrandt, Thomas; Sandberg, Lene

    2016-01-01

    We report on experiences from a case study applying a constraint-based process-modelling and -simulation tool, dcrgraphs.net, to the modelling and rehearsal of railway emergency response plans with domain experts. The case study confirmed the approach as a viable means for domain experts to analyse...

  17. Ghana taking steps to reduce poverty in response to report on fuel ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-06-07

    Ghana taking steps to reduce poverty in response to report on fuel subsidies. June 07, 2016. Image. A Senegalese boy standing behind a car tire. Scott Wallace / The World Bank. John Cockburn. Can social protection through cash transfers help Ghana address the widening gap between rich and poor that its fuel subsidies ...

  18. TERRA-KLEEN RESPONSE GROUP, INC. SOLVENT EXTRACTION TECHNOLOGY: INNOVATIVE TECHNOLOGY EVALUATION REPORT

    Science.gov (United States)

    This report summarizes the results of a field demonstration conducted under the SITE program. The technology which was demonstrated was a solvent extraction technology developed by Terra-Kleen Response Group. Inc. to remove organic contaminants from soil. The technology employs...

  19. Information disclosure in corporate social responsibility reports. The case of Lithuanian companies

    Directory of Open Access Journals (Sweden)

    Sviesa Leitoniene

    2016-09-01

    Full Text Available Though the phenomenon of corporate social responsibility (CSR is closely scrutinized in studies of both Lithuanian and foreign scholars, the problem is the quality of social information disclosed in social re- sponsibility reports. The objective of this article is to analyse the quality of disclosed information in CRS reports of Lithuanian companies. The characteristics of quality of information were comparability, relia- bility, objectivity and sustainability. The research demonstrated that in Lithuania, CSR reports provide unreliable information, which is only partly comparable and objective, however, relatively sustainable.

  20. Extended Performance Reporting: Evaluating Corporate Social Responsibility And Intellectual Capital Management

    Directory of Open Access Journals (Sweden)

    James Guthrie

    2007-06-01

    Full Text Available Recent corporate scandals have resulted in heightened attention towards the shortcomings of traditional financial reporting frameworks. Concurrently, the rise of the corporate social responsibility imperative has led to criticisms that financial reports resent an incomplete account  of a firm‟s activities. In addition, growing acknowledgement of the importance of a firm‟s intangibles and intellectual capital has been associated with increased commentary about the need for extra disclosures if a more complete picture of the firm‟s value is to be provided to external stakeholders. This paper responds to these concerns by developing an extended performance reporting framework to the Australian Food and Beverage Industry, which is characterised by both corporate social responsibility and intellectual capital issues.  In relation to the latter, this framework presents a novel attempt to develop an industry-customised framework as called for by both industry bodies and researchers in the area.

  1. Is suicide reporting in Indian newspapers responsible? A study from Rajasthan.

    Science.gov (United States)

    Jain, Nikhil; Kumar, Sunil

    2016-12-01

    Media reporting has consistently been shown to influence suicidal behaviour. Irresponsible reporting by the media can lead to imitative suicidal behaviour. The WHO has delineated guidelines for responsible media reporting of suicide. The study aims to examine whether Indian newspapers adhere to the WHO guidelines and whether there are differences in style of reporting between local and national newspapers and between English and Hindi newspapers. The study was conducted on ten newspaper publications that were circulated in Jaipur, India from 1st October 2014 to 31st December 2014. All ten newspapers were screened daily for news items related to suicide. Each news item so obtained was studied in detail and then rated using a scale developed in India by psychiatrists and journalists. This scale is based on the WHO guidelines. On an average a newspaper publishes one news item related to suicide every other day. Suicide reporting in Indian newspapers has a strong inclination towards sensationalism. No effort was made to include any educative material the reports. On the positive side most newspapers did not publish the photograph of deceased, or glorify the victims. The newspapers did not try to portray suicide as understandable and were largely neutral in their reporting. The reporting patterns were similar across regional and national newspapers as also across Hindi and English language newspapers. Suicide reporting in India is largely irresponsible and efforts should be made to sensitise media personnel in this regard. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. Self-reported social functioning and prefrontal hemodynamic responses during a cognitive task in schizophrenia.

    Science.gov (United States)

    Pu, Shenghong; Nakagome, Kazuyuki; Itakura, Masashi; Yamanashi, Takehiko; Sugie, Takuya; Miura, Akehiko; Satake, Takahiro; Iwata, Masaaki; Nagata, Izumi; Kaneko, Koichi

    2015-10-30

    Impaired social functioning is a characteristic of schizophrenia that affects patients' quality of life. The aim of the study was to assess prefrontal hemodynamic responses during a cognitive task and establish its influence on psychiatric symptoms, cognitive function, global functioning, and self-reported social functioning in patients with schizophrenia. Thirty-three patients with schizophrenia and 30 age-and sex-matched healthy controls participated in the study. We measured hemodynamic responses in the prefrontal and superior temporal cortical surface areas with 52-channel near-infrared spectroscopy (NIRS) during a verbal fluency task (VFT). Self-reported social functioning was assessed using the Social Functioning Scale (SFS). Regional hemodynamic responses were significantly smaller in the prefrontal and temporal regions in subjects with schizophrenia than in the controls, and prefrontal hemodynamic responses during the VFT showed a strong correlation with SFS total scores. These results suggest an association between self-reported social functioning and prefrontal activation in subjects with schizophrenia. The present study provides evidence that NIRS imaging could be helpful in understanding the neural basis of social functioning. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  3. Responsible Development of Areva's Mining Activities - Report 2011

    International Nuclear Information System (INIS)

    2012-09-01

    The results consolidated at Mining Business Group level and presented in this document mainly relate to the uranium production sites for which Areva is the majority operator. For each stage of the mining life cycle (exploration, project development, operation, closure, redevelopment) much of the data is also reported on a national and international reporting level, and is presented in this document when deemed necessary for the understanding of Areva's activities. This document reports the extra-financial performance of Areva's mining activities for the period from 1 January to 31 December 2011. The extra-financial performance of mining activities presented in this report is underpinned by the Areva group reporting process called STAR (for Sustainability Tools Advanced Reporting). It is supplemented by information collected from in-house experts or from other reporting documents deemed to be valid sources of reference for the subjects discussed. Content: 1 - Approach to responsibility (Being a Responsible Mining Stakeholder, The Fundamentals of Areva's Approach); 2 - Activities (Activities Experiencing Strong Growth, Uranium as a Core Business); 3 - Teams (A Proactive Employment Policy, Employee Health and Safety, Focus: 'I am committed to maintaining safety' campaign yields exemplary results in Namibia); 4 - Environmental policy (Management of Challenges, The Environment Throughout the Entire Mining Lifecycle, Focus: hybrid electricity generation system for prospecting camps in Australia); 5 - Social commitment (Transparency and Openness to Dialogue, Community Involvement, Focus: working group with communities of the province of Saskatchewan in Canada); 6 - Performance (The Main Sustainable Development Indicators, Scope of this Report); 7 - Appendices (Glossary, Communications associated with this report)

  4. Prenatal reporting to child protection: Characteristics and service responses in one Australian jurisdiction.

    Science.gov (United States)

    Taplin, Stephanie

    2017-03-01

    Prenatal reporting to child protection services has been enacted into most jurisdictions across Australia and in other countries, its aims being to intervene early and provide supports which will either identify or prevent the need for a baby to be taken into care and protection once born. Despite indications that there are increasing numbers of prenatal reports, little is known about the characteristics of those reported, the timing and reasons for reports, service responses, and the impacts of being reported. This study is one of the first to use administrative data to examine the characteristics of two samples from one Australian jurisdiction: (i) data from casefiles of 38 cases reported in 2012-13, and (ii) administrative data from 117 cases reported prenatally in 2013. These data showed that women who were reported to child protection services in relation to their pregnancy were predominantly disadvantaged, and were likely to be reported relatively late in their pregnancy due to 'future risk concerns'. Approximately two-thirds of those reported were provided with some prenatal support, as recorded by the child protection system, generally of limited duration. Twelve percent of the babies born to the larger cohort of women were removed within 100days of their birth. It is likely that longer term supportive interventions are needed, to reduce the risk factors evident in women reported during pregnancy, and to improve their ability to safely care for their children. Information on the short and long-term impacts from rigorous evaluations and longer-term intervention trials are also vital to ensure that prenatal reporting and interventions are, in fact, improving outcomes for infants and families. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Occupational safety and health aspects of corporate social responsibility reporting in Japan from 2004 to 2012.

    Science.gov (United States)

    Nagata, Tomohisa; Nakata, Akinori; Mori, Koji; Maruyama, Takashi; Kawashita, Futoshi; Nagata, Masako

    2017-05-02

    A number of companies publish corporate social responsibility (CSR) reporting in booklets and other publicly available formats. The purpose of this paper is to clarify the nine-year (2004-2012) trend of occupational safety and health (OSH) activities as described in CSR reporting (by industry sector and company size). We investigated CSR reporting on the website in all Japanese companies listed on the first section of the Tokyo Stock Exchange. The data were extracted from CSR reporting of each company every year from 2004 to 2012. We counted the pages dedicated to information on OSH activities by industry sector and company size and calculated the rate of OSH divided by total CSR-related activities. The number of companies publishing CSR reports increased in all industry sectors, although the rate of inclusion of OSH activity within CSR reports increased only among sectors such as construction, manufacturing, transportation, and commerce. Among all company size, CSR reporting increased constantly throughout all observed years. The proportion of companies that had described OSH in CSR reporting increased from 2004 to 2012, and 76.5% companies had described OSH activities in 2012. The average number of pages of CSR-related report was 34.2 in 2004, increasing to 43.1 in 2012. The proportion of described pages of OSH activities in total CSR reporting increased gradually, and 2.7% in 2012. The focus of CSR reporting gradually shifted from 'environment' to 'social activity including OSH'. Majority of companies are putting more emphasis on OSH in CSR reporting in Japan.

  6. Seismic Safety Margins Research Program. Phase I final report - Subsystem response (Project V)

    International Nuclear Information System (INIS)

    Shieh, L.C.; Chuang, T.Y.; O'Connell, W.J.

    1981-10-01

    This document reports on (1) the computation of the responses of subsystems, given the input subsystem support motion for components and systems whose failure can lead to an accident sequence (radioactive release), and (2) the results of a sensitivity study undertaken to determine the contributions of the several links in the seismic methodology chain (SMC) - seismic input (SI), soil-structure interaction (SSI), structure response (STR), and subsystem response (SUB) - to the uncertainty in subsystem response. For the singly supported subsystems (e.g., pumps, turbines, electrical control panels, etc.), we used the spectral acceleration response of the structure at the point where the subsystem components were mounted. For the multiple supported subsystems, we developed 13 piping models of five safety-related systems, and then used the pseudostatic-mode method with multisupport input motion to compute the response parameters in terms of the parameters used in the fragility descriptions (i.e., peak resultant accelerations for valves and peak resultant moments for piping). Damping and frequency were varied to represent the sources of modeling and random uncertainty. Two codes were developed: a modified version of SAPIV which assembles the piping supports into groups depending on the support's location relative to the attached structure, and SAPPAC a stand-alone modular program from which the time-history analysis module is extracted. On the basis of our sensitivity study, we determined that the variability in the combined soil-structure interaction, structural response, and subsystem response areas contribute more to uncertainty in subsystem response than does the variability in the seismic input area, assuming an earthquake within the limited peak ground acceleration range, i.e., 0.15 to 0.30g. The seismic input variations were in terms of different earthquake time histories. (author)

  7. Systems for arctic spill response. Volume I. Final report, August 1977--March 1978

    Energy Technology Data Exchange (ETDEWEB)

    Schultz, L.A.; Deslauriers, P.C.; DeBord, F.W.; Voelker, R.P.

    1978-03-01

    This final report summarizes the work accomplished under the program entitled 'Study to Define Arctic Pollution Response Systems and Develop Arctic Oil Pollution Response Project Plans.' The objective of the program was to determine the most cost effective, environmentally compatible, and technically feasible Coast Guard arctic pollution response system that can be used in projected oil spill scenarios to recover and dispose of spilled oil. The optimum arctic pollution response system was determined by establishing the cost and effectiveness of response for sixteen oil spill response situations, and developing six alternative Coast Guard arctic pollution response systems based on these situations. These six systems were developed with a recognition of three distinctly different types of operational requirements, those for thick stable ice, dynamic hummocky ice, and open water or light ice conditions. The optimum system was then identified as the result of a cost effectiveness analysis. The six arctic oil spill scenarios consisted of a gathering pipeline rupture in the nearshore Beaufort Sea, an oil well blowout from a very large reservoir in the nearshore Chukchi Sea, crude oil tanker casualties in Norton Sound and in the Navarin Basin region of the Bering Sea, an oil well blowout from an average sized reservoir in Bristol Bay, and a fuel oil spill resulting from the collision of a fuel oil barge in Unimak Pass. The optimum system provides for a 25% response level for the Norton Sound, Navarin Basin, Bristol Bay, and Unimak Pass scenarios, and a 50% response level for the Beaufort Sea and Chukchi Sea scenarios.

  8. Systems for arctic spill response. Volume II. Appendices. Final report, August 1977--March 1978

    Energy Technology Data Exchange (ETDEWEB)

    Schultz, L.A.; Deslauriers, P.C.; DeBord, F.W.; Voelker, R.P.

    1978-03-01

    This final report summarizes the work accomplished under Phase I of the program entitled 'Study to Define Arctic Pollution Response Systems and Develop Arctic Oil Pollution Response Project Plans.' The objective of Phase I of the program was to determine the most cost effective, environmentally compatible, and technically feasible Coast Guard arctic pollution response system that can be used in projected oil spill scenarios to recover and dispose of spilled oil. The optimum arctic pollution response system was determined by establishing the cost and effectiveness of response for sixteen oil spill response situations, and developing six alternative Coast Guard arctic pollution response systems based on these situations. The optimum system was then identified as the result of a cost effectiveness analysis. The six arctic oil spill scenarios consisted of a gathering pipeline rupture in the nearshore Beaufort Sea, an oil well blowout from a very large reservoir in the nearshore Chukchi Sea, crude oil tanker casualties in Norton Sound and in the Navarin Basin region of the Bering Sea, an oil well blowout from an average sized reservoir in Bristol Bay, and a fuel oil spill resulting from the collision of a fuel oil barge in Unimak Pass. The optimum system provides for a 25% response level for the Norton Sound, Navarin Basin, Bristol Bay, and Unimak Pass scenarios, and a 50% response level for the Beaufort Sea and Chukchi Sea scenarios. Modifications in the optimum system required to extend its capability to subarctic applications in the Great Lakes, the northern rivers, and the northern coastal region were also identified.

  9. Environmental and social responsibility reporting. Do Macedonian companies disclose those information and how?

    Directory of Open Access Journals (Sweden)

    Mrsik Jadranka

    2015-12-01

    Full Text Available Incorporating environmental impact into financial reports is becoming standard practice in the 21st Century. Investors are aware of the need for environmentally correct operations since failures in this domain lower the price of shares. However, in terms of regulation, in most of the countries, environmental reporting remains voluntary. Institutions dealing with development and promotion of the modern accounting and financial reporting standards encourage companies to concurrently report for their environmental activities. The only question is how. Accounting may include information on the environmental impact only if it is quantitative and monetary. Since many nuances of the issues remain difficult to quantify, corporations opt to separately report on their environmental practices. The aim of this paper is to examine the accounting and stock market regulations and the practice of reporting for environmental impact of the operations of the leading Macedonian companies. We selected ten companies that make the Macedonian Stock Exchange Index and additional five companies with significant environmental impact. We reviewed their annual reports and interviewed their financial officers. The results show that the environmental and social responsibility reporting is left to the companies and their management and its perception of the need for keeping posted the major stakeholders and the most appropriate way to do it. As a consequence, many large Macedonian companies do not refer to these issues in their annual addressing to the stakeholders. The findings of this paper can motivate the regulatory body and the government to require more transparency and disclosure of the sustainability information.

  10. Brief report: Response inhibition and processing speed in children with motor difficulties and developmental coordination disorder.

    Science.gov (United States)

    Bernardi, Marialivia; Leonard, Hayley C; Hill, Elisabeth L; Henry, Lucy A

    2016-01-01

    A previous study reported that children with poor motor skills, classified as having motor difficulties (MD) or Developmental Coordination Disorder (DCD), produced more errors in a motor response inhibition task compared to typically developing (TD) children but did not differ in verbal inhibition errors. The present study investigated whether these groups differed in the length of time they took to respond in order to achieve these levels of accuracy, and whether any differences in response speed could be explained by generally slow information processing in children with poor motor skills. Timing data from the Verbal Inhibition Motor Inhibition test were analyzed to identify differences in performance between the groups on verbal and motor inhibition, as well as on processing speed measures from standardized batteries. Although children with MD and DCD produced more errors in the motor inhibition task than TD children, the current analyses found that they did not take longer to complete the task. Children with DCD were slower at inhibiting verbal responses than TD children, while the MD group seemed to perform at an intermediate level between the other groups in terms of verbal inhibition speed. Slow processing speed did not account for these group differences. Results extended previous research into response inhibition in children with poor motor skills by explicitly comparing motor and verbal responses, and suggesting that slow performance, even when accurate, may be attributable to an inefficient way of inhibiting responses, rather than slow information processing speed per se.

  11. REPORTING CORPORATE SOCIAL RESPONSIBILITY: AT THE PURSUIT OF LEGITIMACY - A LITERATURE REVIEW

    Directory of Open Access Journals (Sweden)

    Rim Lahbil

    2017-09-01

    Full Text Available Since one of today’s business buzzwords is “Sustainability”, an increasingly large number of companies aim to generate a lasting competitive advantage by balancing the value creating process with the social and environmental challenges. Therefore, Corporate Social Responsibility (CSR appears as the assertive voice in which corporate governance is expressed in terms of sustainable development. The widespread adoption of sustainability reporting (SR confirms companies' growing awareness of their social responsibilities. The researches previously conducted present mainly two drivers for sustainability reporting. Firstly, it is seen as a communication technique. Secondly, it is a legal obligation, driven by national and international laws. Thus, the credibility of sustainability reporting seems to be relevant to question. The literature review reveals that scholars and practitioners have largely focused on the determinants of this form of communication, used media, content and recipients. Although the reliability of the information has often been questioned, it is the least studied empirically. By adopting internal control mechanisms and privileging external audits, an arsenal of arrangements is used in order to improve the credibility and the transparency of social and environmental information. Through a theoretical and empirical synthesis of the literature exploring the SR research field, this paper answers two major questions: what value for the sustainability reporting and how can their legitimacy be assured? The findings imply that, subjected to various institutional and regulatory pressures, companies tend to adopt societal reporting practices. It is mainly intended to guarantee trust and reliability in the information transmitted to the public.

  12. Media awards for responsible reporting of suicide: Experiences from Australia, Belgium and Denmark.

    Science.gov (United States)

    Dare, Andrew J; Andriessen, Karl Am; Nordentoft, Merete; Meier, Michella; Huisman, Annemiek; Pirkis, Jane E

    2011-06-03

    Media awards to encourage responsible reporting of suicide have been introduced in several countries, including Australia, Belgium and Denmark. This study aimed to examine the experiences of Australian, Belgian and Danish award recipients in preparing stories on suicide, and consider the impacts of the awards for these recipients and for media professionals more broadly. We conducted semi-structured telephone interviews with the majority (14 out of 15) of past recipients of the awards in the three countries of interest. Media awards appear to show promise as a method of reinforcing national and international media guidelines on reporting suicide. The recipients of awards were proud to have had their achievements recognized in this way, and had developed a heightened awareness of the issues inherent in reporting suicide. Although relatively few had prepared subsequent stories on suicide, a number had been given opportunities to provide advice to other media professionals about how best to approach this sensitive topic. Recipients viewed the awards as an important means by which good quality reporting can be rewarded, and a springboard for raising community awareness about suicide. The experience from Australia, Belgium and Denmark suggests that media awards which recognize responsible reporting of suicide are extremely worthwhile.

  13. Evidence Report: Risk of Crew Adverse Health Event Due to Altered Immune Response

    Science.gov (United States)

    Crucian, Brian; Sams, Clarence F.

    2013-01-01

    The Risk of Crew Adverse Health Event Due to Altered Immune Response is identified by the National Aeronautics and Space Administration (NASA) Human Research Program (HRP) as a recognized risk to human health and performance in space. The HRP Program Requirements Document (PRD) defines these risks. This Evidence Report provides a summary of the evidence that has been used to identify and characterize this risk. It is known that human immune function is altered in- and post-flight, but it is unclear at present if such alterations lead to increased susceptibility to disease. Reactivation of latent viruses has been documented in crewmembers, although this reactivation has not been directly correlated with immune changes or with observed diseases. As described in this report, further research is required to better characterize the relationships between altered immune response and susceptibility to disease during and after spaceflight. This is particularly important for future deep-space exploration missions.

  14. Validated Models for Radiation Response and Signal Generation in Scintillators: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Kerisit, Sebastien N.; Gao, Fei; Xie, YuLong; Campbell, Luke W.; Van Ginhoven, Renee M.; Wang, Zhiguo; Prange, Micah P.; Wu, Dangxin

    2014-12-01

    This Final Report presents work carried out at Pacific Northwest National Laboratory (PNNL) under the project entitled “Validated Models for Radiation Response and Signal Generation in Scintillators” (Project number: PL10-Scin-theor-PD2Jf) and led by Drs. Fei Gao and Sebastien N. Kerisit. This project was divided into four tasks: 1) Electronic response functions (ab initio data model) 2) Electron-hole yield, variance, and spatial distribution 3) Ab initio calculations of information carrier properties 4) Transport of electron-hole pairs and scintillation efficiency Detailed information on the results obtained in each of the four tasks is provided in this Final Report. Furthermore, published peer-reviewed articles based on the work carried under this project are included in Appendix. This work was supported by the National Nuclear Security Administration, Office of Nuclear Nonproliferation Research and Development (DNN R&D/NA-22), of the U.S. Department of Energy (DOE).

  15. Socially Responsible Investment and Fiduciary Duty: Putting the Freshfields Report into Perspective

    OpenAIRE

    Sandberg, Joakim

    2010-01-01

    A critical issue for the future growth and impact of socially responsible investment (SRI) is whether institutional investors are legally permitted to engage in it – in particular whether it is compatible with the fiduciary duties of trustees. An ambitious report from the United Nations Environment Programme’s Finance Initiative (UNEP FI), commonly referred to as the ‘Freshfields report’, has recently given rise to considerable optimism on this issue among proponents of SRI. The present paper...

  16. The Social Construction of the Responsible Corporate Citizen: Sustainability Reports of the Global Automotive Firms

    OpenAIRE

    Shinkle, George; Spencer, J. William

    2008-01-01

    The constitutive meanings of responsible corporate environmental citizenship are to be found in global discourses. We use Gubrium and Holstein‘s framework on interpretive practice to study the Corporate Sustainability Reports of multinational automotive companies regarding global warming. We observe three common themes – recognizing the issue of greenhouse gases, acknowledging stakeholders, and being role models for society. However, these themes take on unique meanings vis-à-vis each corpora...

  17. REPORTING CORPORATE SOCIAL RESPONSIBILITY: AT THE PURSUIT OF LEGITIMACY - A LITERATURE REVIEW

    OpenAIRE

    Rim Lahbil; Rachid Wahabi

    2017-01-01

    Since one of today’s business buzzwords is “Sustainability”, an increasingly large number of companies aim to generate a lasting competitive advantage by balancing the value creating process with the social and environmental challenges. Therefore, Corporate Social Responsibility (CSR) appears as the assertive voice in which corporate governance is expressed in terms of sustainable development. The widespread adoption of sustainability reporting (SR) confirms companies' growing ...

  18. Financial Reporting for Environmental and Social responsibility: A Normative Strategic Concept

    OpenAIRE

    Jean Raar

    2004-01-01

    Corporate responsibility demands that firms address environmental and social values in their firm’s policy and key performance indicators. These are integrated through strategic planning and require firms to merge the longer term environmental and social values with short term economic objectives and performance measures. Each firm’s strategy will differ. This paper provides a normative reporting concept to connect the financial implications associated with longer term planning for environmen...

  19. THE RESPONSIBILITY OF PHYSICIAN TO PREPARE A FORENSIC AND MEDICAL REPORT

    Directory of Open Access Journals (Sweden)

    Mehmet TOYGAR

    2006-12-01

    Full Text Available Physicians have responsibilities to prepare forensic and expertise reports besides their role in treatment, diagnosis and preventive medicine. A physician who engaged in treatment should have sufficient knowledge and experience to prepare the requested forensic or medical expertise reports. These expertise reports are usually requested either by criminal law or civil law courts, besides, calculation of the physical disabilities should be demanded at the basis of Armed Forces Pension Fund (OYAK Law and monetary compensation. New Turkish Penal Code highlights the new implementations about severity of injuries caused by trauma. According to the interpretation of Military Supreme Court, the severity of injuries caused by trauma in Military Penal Code is evaluated under the light of Turkish Penal Code. Determination of the rate of disabilities in general body functions and loss of daily activity have been often requested for reports concerning the civil law. Different legislations have been used for reports at the basis of monetary compensation. The purpose of this study is to scrutinize the problems encountered while preparing forensic and medical expertise reports and implementing the relevant and appropriate legal procedure and to emphasize the important points to be considered during the preparation of these expertise reports. [TAF Prev Med Bull 2006; 5(6.000: 466-475

  20. Demand response pilot event conducted August 2,2011 : summary report.

    Energy Technology Data Exchange (ETDEWEB)

    Lincoln, Donald; Evans, Christoper

    2012-01-01

    Energy management in a commercial facility can be segregated into two areas: energy efficiency and demand response (DR). Energy efficiency focuses on steady-state load minimization. Demand response reduces load for event driven periods during the peak load. Demand-response-driven changes in electricity use are designed to be short-term in nature, centered on critical hours during the day when demand is high or when the electricity supplier's reserve margins are low. Due to the recent Federal Energy Regulatory Commission (FERC) Order 745, Demand Response Compensation in Organized Wholesale Energy Markets the potential annual compensation to Sandia National Laboratories (SNL) from performing DR ranges from $300K to $2,400K. While the current energy supply contract does not offer any compensation for participating in DR, there is benefit in understanding the issues and potential value in performing a DR event. This Report will be helpful in upcoming energy supply contract negotiations to quantify the energy savings and power reduction potential from DR at SNL. On August 25, 2011 the Facilities Management and Operations Center (FMOC) performed the first DR pilot event at SNL/NM. This report describes the details and results of this DR event.

  1. Long lasting clinical response to chemotherapy for advanced uterine leiomyosarcoma: a case report.

    Science.gov (United States)

    Ridolfi, Claudio; Pasini, Giuseppe; Drudi, Fabrizio; Barzotti, Eleonora; Santelmo, Carlotta; Polselli, Antonio; Ravaioli, Alberto

    2013-01-24

    Uterine leiomyosarcoma is one of the most frequent uterine sarcomas. In the metastatic setting it is sensitive to doxorubicin, ifosfamide, gemcitabine, docetaxel and a few other drugs, but time to progression is generally short. For this reason prognosis is often poor and there are few reports in the literature of long responders. We report a case of a 40-year-old Caucasian woman with metastatic uterine leiomyosarcoma who began treatment six years before the presentation of this case report and for the following six years underwent ten lines of chemotherapy, achieving excellent results and a good quality of life. Among the treatments administered we observed a long response to temolozomide, an unconventional drug for this kind of disease. Although there are few chemotherapeutic options for the management of metastatic uterine leiomyosarcoma, a small number of patients have an unexpected long lasting response to treatment. For this reason further research is needed to identify new therapeutic agents and the predictive factors for the achievement of response.

  2. Long lasting clinical response to chemotherapy for advanced uterine leiomyosarcoma: a case report

    Directory of Open Access Journals (Sweden)

    Ridolfi Claudio

    2013-01-01

    Full Text Available Abstract Introduction Uterine leiomyosarcoma is one of the most frequent uterine sarcomas. In the metastatic setting it is sensitive to doxorubicin, ifosfamide, gemcitabine, docetaxel and a few other drugs, but time to progression is generally short. For this reason prognosis is often poor and there are few reports in the literature of long responders. Case presentation We report a case of a 40-year-old Caucasian woman with metastatic uterine leiomyosarcoma who began treatment six years before the presentation of this case report and for the following six years underwent ten lines of chemotherapy, achieving excellent results and a good quality of life. Among the treatments administered we observed a long response to temolozomide, an unconventional drug for this kind of disease. Conclusion Although there are few chemotherapeutic options for the management of metastatic uterine leiomyosarcoma, a small number of patients have an unexpected long lasting response to treatment. For this reason further research is needed to identify new therapeutic agents and the predictive factors for the achievement of response.

  3. Smokers' self-reported responses to the introduction of reduced ignition propensity (RIP) cigarettes.

    Science.gov (United States)

    Seidenberg, Andrew B; Rees, Vaughan W; Alpert, Hillel R; O'Connor, Richard J; Giovino, Gary A; Hyland, Andrew; Connolly, Gregory N

    2012-05-01

    Changes in cigarette design to meet mandated fire safety standards may have unintended effects on smoker responses by diminishing the consumer's perceptions of product acceptability, smoking and increasing fire-risk behaviours. To address these concerns, population-level data are needed from a jurisdiction where reduced ignition propensity (RIP) cigarettes have been introduced. A cohort of adult smokers was recruited in Massachusetts, U.S.A. using a random-digit-dialed telephone survey. The cohort was contacted prior to, and 8 months following, the state-mandated introduction of RIP cigarettes on 1 January 2008. Changes in self-reported subjective cigarette characteristics, smoking topography, fire-risk behaviours, fire events and quitting intentions were assessed. A total of 620 Massachusetts smokers completed the baseline survey conducted prior to implementation of the law, and 353 (57%) completed the follow-up survey conducted after implementation. No significant changes were found in self-reported fire-risk behaviour or quitting intentions. In addition, smokers were less likely to report smoking greater than 20 cigarettes per day and inhaling deeply into the chest after the law. The introduction of RIP cigarettes in Massachusetts yielded little change, and no adverse effect, on self-reported smoker response, among a sample of mostly Caucasian smokers.

  4. Unresectable Recurrent Multiple Meningioma: A Case Report with Radiological Response to Somatostatin Analogues

    Directory of Open Access Journals (Sweden)

    Ana Ortolá Buigues

    2016-08-01

    Full Text Available Medical treatment of meningiomas is reserved for cases in which surgery and radiotherapy have failed. Given that a high percentage of meningiomas express somatostatin receptors, treatment with somatostatin analogues has been proposed. In addition, these medications have been shown to have an antiproliferative and antiangiogenic effect in vitro. To date, very few cases with clinical response and none with radiological response have been described. The case described here is the first to report a radiological response. A 76-year-old Caucasian male was first diagnosed with unresectable meningioma at age 47. The patient experienced multiple recurrences and underwent three surgeries and radiotherapy over the years from the initial diagnosis. Despite treatment, the disease continued its progression. Based on an Octreoscan positive for tumour uptake, therapy with extended-release somatostatin analogues was started. Although no clinical neurological improvement was observed, magnetic resonance imaging scans revealed a discreet but continuous radiological response over time. After >2 years of continuous administration of lanreotide, the patient remains progression free. In highly selected cases, somatostatin analogue treatment for meningioma may be beneficial. Based on our findings, treatment with somatostatin analogues should be maintained longer than previously described before evaluating treatment response.

  5. Visually-evoked pattern and photomyoclonic responses in video game and television epilepsy: case reports.

    Science.gov (United States)

    Anyanwu, E; Watson, N A

    1996-01-01

    This research paper reports a case study of two male photosensitive epileptic patients, aged 14 and 16 years old respectively, whose epileptic seizures were often triggered by the flickers from television and video games respectively. The 14-year old patient had no family history of epilepsy, while the 16 year old had a family history of epilepsy. A comprehensive electroencephalogram (EEG), including hyperventilation, intermittent photic stimulation (IPS) and pattern stimulation were carried out on them and EEG abnormalities including photoparoxysmal responses (PPR) and generalized myoclonic responses were evoked. A thorough analysis of the EEG morphology of the myclonic responses and the clinical manifestations showed evidence of two separate entitles of seizures namely: visually evoked pattern-myoclonic responses (PTMR) and visually evoked photomyoclonic responses (PMR). PTMR was independent of flash rate and occurred before a PPR and at the same time as the flash rate, while PMR occurred after the PPR and was dependent on flash rate. These findings suggest that "Video Game" epilepsy is probably a pattern sensitive epilepsy, electronic screen being the source of the triggering patterns; hence, the morphology and the family histories and the myoclonic phenomena differ from those of pure photosensitive epilepsy.

  6. PAT-1 safety analysis report addendum author responses to request for additional information.

    Energy Technology Data Exchange (ETDEWEB)

    Weiner, Ruth F.; Schmale, David T.; Kalan, Robert J.; Akin, Lili A.; Miller, David Russell; Knorovsky, Gerald Albert; Yoshimura, Richard Hiroyuki; Lopez, Carlos; Harding, David Cameron; Jones, Perry L.; Morrow, Charles W.

    2010-09-01

    The Plutonium Air Transportable Package, Model PAT-1, is certified under Title 10, Code of Federal Regulations Part 71 by the U.S. Nuclear Regulatory Commission (NRC) per Certificate of Compliance (CoC) USA/0361B(U)F-96 (currently Revision 9). The National Nuclear Security Administration (NNSA) submitted SAND Report SAND2009-5822 to NRC that documented the incorporation of plutonium (Pu) metal as a new payload for the PAT-1 package. NRC responded with a Request for Additional Information (RAI), identifying information needed in connection with its review of the application. The purpose of this SAND report is to provide the authors responses to each RAI. SAND Report SAND2010-6106 containing the proposed changes to the Addendum is provided separately.

  7. Corporate Social Responsibility Reporting and Earnings Management: The Role of Political Costs

    Directory of Open Access Journals (Sweden)

    Erica Yip

    2011-09-01

    Full Text Available Recently, Francis, Nanda and Olsson (2008 proposed that earnings quality influence firms’ disclosure decisions. We examine whether Corporate Social Responsibility (CSR disclosure is related to earnings management and if the relationship is mitigated by political cost considerations or by the firm’s ethical predisposition. We argue that the relationship between CSR reporting and earnings management is context-specific and we consider one particular context, the political environment. We test our hypotheses by regressing earnings management on CSR disclosure while controlling for other factors that may affect the level of earnings management. We find a significant relationship between CSR reporting and earnings management, and more specifically, we find evidence of a negative (complementary relationship in the oil and gas industry while we find evidence of a positive (substitutive relationship in the food industry. The evidence supports the view that the relationship between CSR reporting and earnings management is affected by the political environment and not by ethical considerations.

  8. Predictors of men's sexual response to erotic film stimuli: the role of affect and self-reported thoughts.

    Science.gov (United States)

    Oliveira, Cátia; Laja, Pedro; Carvalho, Joana; Quinta Gomes, Ana; Vilarinho, Sandra; Janssen, Erick; Nobre, Pedro J

    2014-11-01

    Both emotions and cognitions seem to play a role in determining sexual arousal. However, no studies to date have tested the effects of self-reported thoughts on subjective sexual arousal and genital response using psychophysiological methods. The aim of the present study was to evaluate the role of self-reported thoughts and affect during exposure to erotic material in predicting subjective and genital responses in sexually healthy men. Twenty-seven men were presented with two explicit films, and genital responses, subjective sexual arousal, self-reported thoughts, and positive and negative affect were assessed. Men's genital responses, subjective sexual arousal, affective responses, and self-reported thoughts during exposure to sexual stimulus were measured. Regression analyses revealed that genital responses were predicted by self-reported thoughts (explaining 20% of the variance) but not by affect during exposure to erotic films. On the other hand, subjective sexual arousal was significantly predicted by both positive and negative affect (explaining 18% of the variance) and self-reported thoughts (explaining 37% of the variance). Follow-up analyses using the single predictors showed that "sexual arousal thoughts" were the only significant predictor of subjective response (β = 0.64; P thoughts" were the best predictor of genital response (β = -0.51; P thoughts play an important role in men's subjective sexual response, whereas genital response seems to be better predicted by distracting thoughts. © 2014 International Society for Sexual Medicine.

  9. Responsible Development On Areva's Mining Activities - Report 2013-2014

    International Nuclear Information System (INIS)

    2014-01-01

    Mining activities are the first link in the nuclear fuel cycle and in the integrated model of the Areva Group. Areva was one of the top producers worldwide in 2013, producing 9,330 metric tons of uranium (Areva's financially consolidated share). The group works to maintain resources and weighted reserves equivalent to 20 years of production at all times. Thanks to a presence spanning five continents, they ensure the long-term supply to customers of uranium for electricity production while maintaining a responsible attitude towards people and the environment. It has a diverse portfolio of both active mines (Canada, Kazakhstan and Niger) and mines under development (Africa). This document is Areva's Mining Activities responsible Development report for 2013 and 2014. Content: profile (Overview, Keys events, Worldwide presence, Governance and Organization, Uranium market); CSR approach (Message from the Senior Executive Vice President, Fundamentals, Responsible Commitments Plan, Materiality); Commitments (Health and radiation protection, Occupational safety, Environment and Biodiversity, Community involvement, Commitment to employees, Relationships with stakeholders, Innovation); Performance (Main Key indicators, 2013-2016 Objectives, Reporting parameters); Annexes (Cases studies, Focus post-mining, Audit and GRI certifications)

  10. Dual stimuli responsive self-reporting material for chemical reservoir coating

    Science.gov (United States)

    Lee, Tae Hee; Song, Young Kyu; Park, Sun Hee; Park, Young Il; Noh, Seung Man; Kim, Jin Chul

    2018-03-01

    In this study, we introduce a novel dual stimuli responsive self-reporting thiol-epoxy thermoset (DSRTET) coatings which can detect both crack occurrence and pH variation. For crack detection, microcapsule containing tetraphenylethylene (TPE) which exhibits aggregation induced emission (AIE) effect was prepared via multi-step emulsion polymerization and dispersed in DSRTET coatings. For pH variation detection, commercial thymol blue as a pH indicator was added into the polymer matrix. The effect of microcapsule contents in DSRTET on their curing behavior, material properties, and crack sensitivity was characterized using an oscillatory rheology, rigid body pendulum test (RPT), nano-indentation test (NST), universal test machine (UTM) and scratch tester. It was revealed that crack sensitivity of DSRTET coatings was greatly influenced by material properties as well as microcapsule content. The color transition of DSRTET coatings in response to acid or base solution were quantitatively investigated using a multi-angle spectrophotometer after simple acid and base solution drop tests. The color of DSRTET coatings changed from a pale green to red for acidic solution and to blue for basic solution. Finally, The DSRTET used in this study was applied to laboratory scale chemical reservoirs in order to verify the potential as a dual stimuli response self-reporting coating which can detect both crack in coating material and chemical spill caused by the leakage or breakage of the reservoir part.

  11. Responsible Development On Areva's Mining Activities - Report 2016

    International Nuclear Information System (INIS)

    2017-01-01

    Constituting the first link in the nuclear fuel cycle, New Areva's mining activities cover research, production and commercialization of uranium throughout the world. New Areva counts among the world's leading producers of uranium enjoying competitive production costs and with mines in operation in Canada, Kazakhstan and Niger. Committed to its role as a responsible mining company, New Areva conducts its mining activities in a manner that fully respects people and the environment, and contributes to the economic development of local regions and their populations. Thanks to a presence spanning five continents, they ensure the long-term supply to customers of uranium for electricity production while maintaining a responsible attitude towards people and the environment. It has a diverse portfolio of both active mines (Canada, Kazakhstan and Niger) and mines under development (Africa). This document is Areva's Mining Activities responsible Development report for 2016. Content: profile (Overview, Keys events, Worldwide presence, Governance and Organization, Uranium market); CSR approach (Top management statement, Risk management, Ethics and human rights, Voluntary initiatives, Materiality); Commitments (Health, occupational safety and radiation protection, Environment and Biodiversity, Social involvement, Commitment to employees, Mining closure, R and D and Innovation); Performance (CSR objectives, Key indicators, Reporting parameters); Case Studies; Annexes (GRI Index)

  12. Responsible Development On Areva's Mining Activities - Report 2014

    International Nuclear Information System (INIS)

    2015-01-01

    Mining activities are the first link in the nuclear fuel cycle and in the integrated model of the Areva Group. Areva was one of the top producers worldwide in 2014, producing 8,959 metric tons of uranium. The group works to maintain resources and weighted reserves equivalent to 20 years of production at all times. Thanks to a presence spanning five continents, they ensure the long-term supply to customers of uranium for electricity production while maintaining a responsible attitude towards people and the environment. It has a diverse portfolio of both active mines (Canada, Kazakhstan and Niger) and mines under development (Africa). This document is Areva's Mining Activities responsible Development report for 2014. Content: profile (Overview, Keys events, Worldwide presence, Governance and Organization, Uranium market); CSR approach (Statement from the senior executive vice president, Risk management, Ethics and human rights, Voluntary initiatives, Materiality); Commitments (Health and radiation protection, Occupational safety, Environment and Biodiversity, Community involvement, Commitment to employees, After-mines, Innovation); Performance (Key indicators, Objectives of responsibility, Reporting parameters); Case Studies; Annexes (GRI Index)

  13. The Role Of Grenelle II In Corporate Social Responsibility Integrated Reporting

    Directory of Open Access Journals (Sweden)

    Radoslaw Wolniak

    2013-12-01

    Full Text Available There is in the paper, the analysis of the Grenelle II act from Corporate Social Responsibility reporting point of view. France has long been an important global champion of corporate sustainability reporting. While this trend has advanced the integration of CSR into business practices, the increasing number of regulations has also made it more complicated and costly for international companies to create reports that fulfill the differing requirements of each foreign law. The Grenelle 2 law adopted in July 2010, implements the Grenelle 1 goals. It sets specific objectives, strategic, incentives and regulations. This Act aims at forcing companies to progress in reporting their environmental and social information: there is no sanction (such as fines, requirements are on a “comply or explain” basis and the implementation is progressive. The main advantage of such an Grenelle II Act is a beginning and will have to be rewritten and improved, taking into account the international movement – is to shift minds regarding CSR. CSR and extra-financial information has nothing to do with communication anymore: it is clearly a strategic and management process, facilitated by the reporting process.

  14. Status limbo: analysis of nurse faculty member reports of administrator response to workplace bullying complaints.

    Science.gov (United States)

    Dzurec, Laura Cox

    2013-01-01

    Increasing concern about bullying among adults in workplaces is notable internationally. Unlike blatant physical bullying, workplace bullying often involves bullies' dismissive, demeaning, and typically surreptitious, one-on-one communications with their intended victims. These communications challenge recognition when they are examined beyond the interpersonal margins of the bully-victim dyad. Thus, they tend to elude formal, administrative reproach, despite the negative, long-term outcomes they herald for workplace employees--those immediately involved as victims and those who are bystanders--and for employing organizations and the consumers they serve. This article offers a hermeneutic analysis of workplace bullying victims' narrative reports of administrator responses to their complaints of having been bullied at work. Analysis demonstrated respondent perceptions of the variability and unevenness of administrative responses to their reports and, more broadly, respondents' collective sense of administrative abandonment. That sense is characterized in this report as status limbo, a term employed by Facebook users to represent a state of perceived neglect and oblivion. © 2013 Elsevier Inc. All rights reserved.

  15. Self-reported racial/ethnic discrimination and bronchodilator response in African American youth with asthma

    Science.gov (United States)

    Carlson, Sonia; Borrell, Luisa N.; Eng, Celeste; Nguyen, Myngoc; Thyne, Shannon; LeNoir, Michael A.; Burke-Harris, Nadine

    2017-01-01

    Importance Asthma is a multifactorial disease composed of endotypes with varying risk profiles and outcomes. African Americans experience a high burden of asthma and of psychosocial stress, including racial discrimination. It is unknown which endotypes of asthma are vulnerable to racial/ethnic discrimination. Objective We examined the association between self-reported racial/ethnic discrimination and bronchodilator response (BDR) among African American youth with asthma ages 8 to 21 years (n = 576) and whether this association varies with tumor necrosis factor alpha (TNF-α) level. Materials and methods Self-reported racial/ethnic discrimination was assessed by a modified Experiences of Discrimination questionnaire as none or any. Using spirometry, BDR was specified as the mean percentage change in forced expiratory volume in one second before and after albuterol administration. TNF-α was specified as high/low levels based on our study population mean. Linear regression was used to examine the association between self-reported racial/ethnic discrimination and BDR adjusted for selected characteristics. An interaction term between TNF-α levels and self-reported racial/ethnic discrimination was tested in the final model. Results Almost half of participants (48.8%) reported racial/ethnic discrimination. The mean percent BDR was higher among participants reporting racial/ethnic discrimination than among those who did not (10.8 versus 8.9, p = 0.006). After adjustment, participants reporting racial/ethnic discrimination had a 1.7 (95% CI: 0.36–3.03) higher BDR mean than those not reporting racial/ethnic discrimination. However, we found heterogeneity of this association according to TNF-α levels (p-interaction = 0.040): Among individuals with TNF-α high level only, we observed a 2.78 higher BDR mean among those reporting racial/ethnic discrimination compared with those not reporting racial/ethnic discrimination (95%CI: 0.79–4.77). Conclusions We found BDR to be

  16. Interstitial brachytherapy for liver metastases and assessment of response by positron emission tomography: a case report

    Directory of Open Access Journals (Sweden)

    Goura Kishor Rath

    2010-10-01

    Full Text Available For liver metastases (LM, image guided percutaneous ablative procedures such as radiofrequency ablation (RFA, laser induced thermal therapy (LITT and trans-arterial chemo-embolisation (TACE are increasingly being used because they are relatively safer, less invasive and equally effective. CT scan guided interstitial brachytherapy (IBT with a single large dose of radiation by high dose rate (HDR brachytherapy is a novel technique of treating LM and has shown good results. Positron emission tomography (PET scan may provide better information for assessing the response toIBT procedures. We hereby report a case of LM that was treated by HDR IBT and PET scan was done in addition to CT scan for assessing the response.

  17. Seismic safety margins research program. Phase I final report - Major structure response (Project IV)

    International Nuclear Information System (INIS)

    Benda, B.J.; Johnson, J.J.; Lo, T.Y.

    1981-08-01

    The primary task of the Major Structure Response Project within the Seismic Safety Margins Research Program (SSMRP) was to develop detailed finite element models of the Zion Nuclear Power Plant's containment building and auxiliary-fuel-turbine (AFT) complex. The resulting models served as input to the seismic methodology analysis chain. The containment shell was modeled as a series of beam elements with the shear and bending characteristics of a circular cylindrical shell. Masses and rotary inertias were lumped at nodal points; thirteen modes were included in the analysis. The internal structure was modeled with three-dimensional finite elements, with masses again lumped at selected nodes; sixty modes were included in the analysis. The model of the AFT complex employed thin plate and shell elements to represent the concrete shear walls and floor diaphragms, and beam and truss elements to model the braced frames. Because of the size and complexity of the model, and the potentially large number of degrees of freedom, masses were lumped at a limited number of node points. These points were selected so as to minimize the effect of the discrete mass distribution on structural response. One hundred and thirteen modes were extracted. A second objective of Project IV was to investigate the effects of uncertainty and variability on structural response. To this end, four side studies were conducted. Three of them, briefly summarized in this volume, addressed themselves respectively to an investigation of sources of random variability in the dynamic response of nuclear power plant structures; formulation of a methodology for modeling and evaluating the effects of structural uncertainty on predicted modal characteristics of major nuclear power plant structures and substructures; and a preliminary evaluation of nonlinear responses in shear-wall structures. A fourth side study, reported in detail in this volume, quantified variations in dynamic characteristics and seismic

  18. Human response to nuclear and advanced technology weapons effects. Final report, January-December 1995

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, J.L.

    1996-05-01

    The purpose of this study is to help the system survivability analyst estimate hardness requirements for systems exposed to nuclear weapons and advanced technology weapons (ATWs). The system survivability analyst is often asked to make quick, order-of-magnitude estimates on the hardness requirements for existing or proposed systems based upon human responses to the effects of nuclear weapons and ATWs. The intent of this report is to identity the general range of human survivability to nuclear weapons and ATWs and to provide simple example calcuiations and scenarios that can give the reader rough estimates of the effects of these weapons. While high-powered microwave (HPM) and laser weapons are considered in this report, the main emphasis is on nuclear weapons and their ionizing radiation effects.

  19. Giant cell tumor of the uterus: case report and response to chemotherapy

    International Nuclear Information System (INIS)

    Skubitz, Keith M; Manivel, J Carlos

    2007-01-01

    Giant cell tumor (GCT) is usually a benign but locally aggressive primary bone neoplasm in which monocytic macrophage/osteoclast precursor cells and multinucleated osteoclast-like giant cells infiltrate the tumor. The etiology of GCT is unknown, however the tumor cells of GCT have been reported to produce chemoattractants that can attract osteoclasts and osteoclast precursors. Rarely, GCT can originate at extraosseous sites. More rarely, GCT may exhibit a much more aggressive phenotype. The role of chemotherapy in metastatic GCT is not well defined. We report a case of an aggressive GCT of the uterus with rapidly growing lung metastases, and its response to chemotherapy with pegylated-liposomal doxorubicin, ifosfamide, and bevacizumab, along with a review of the literature. Aggressive metastasizing GCT may arise in the uterus, and may respond to combination chemotherapy

  20. U.S. response to a report of infectious salmon anemia virus in Western North America

    Science.gov (United States)

    Amos, Kevin H; Gustafson, Lori; Warg, Janet; Whaley, Janet; Purcell, Maureen K.; Rolland, Jill B.; Winton, James R.; Snekvik, Kevin; Meyers, Theodore; Stewart, Bruce; Kerwin, John; Blair, Marilyn; Bader, Joel; Evered, Joy

    2014-01-01

    Federal, state, and tribal fishery managers, as well as the general public and their elected representatives in the United States, were concerned when infectious salmon anemia virus (ISAV) was suspected for the first time in free-ranging Pacific Salmon collected from the coastal areas of British Columbia, Canada. This article documents how national and regional fishery managers and fish health specialists of the U.S. worked together and planned and implemented actions in response to the reported finding of ISAV in British Columbia. To date, the reports by Simon Fraser University remain unconfirmed and preliminary results from collaborative U.S. surveillance indicate that there is no evidence of ISAV in U.S. populations of free-ranging or marine-farmed salmonids on the west coast of North America.

  1. [The social responsibility report drafting in healthcare facilities. Experiences in Fatebenefratelli's Hospitals].

    Science.gov (United States)

    Roberti, Giovanni; Franco, Claudia; Pimpinella, Giovanni; Piscioneri, Patrizia; Primavera, Angela; Bonannini, Barbara; Calvo, Manlio; Pavese, Ida; Di Palma, Mario; Fiore, Rosalia

    2013-01-01

    Medical facilities have the duty to report, in a transparent, comprehensive and integrated manner, their performance, not only in relation to the services provided directly but also in relation to the interest of the various stakeholders and the economic and social benefits for the community. The Social Report is not only a communication tool related to corporate social responsibility but also the initial basis for acquiring social legitimacy, and serves the role of "social accounting" of the activities of an organization, with respect to its mission and institutional role. In healthcare, it can contribute to achieving the fundamental objectives of the healthcare system, in the financial area (fair financing), and also in the medical (outcomes) and ethical-social areas.

  2. Response to state comments on the draft regional characterization reports for the Crystalline Repository Project

    International Nuclear Information System (INIS)

    1984-11-01

    In May, 1983, the US Department of Energy (DOE) Crystalline Repository Project Office (CPO) issued six draft Regional Characterization Reports (RCRs) for review and comment to the 17 Crystalline States comprising the Northeastern, Southeastern, and North Central crystalline regions. Comment letters were received from 13 of the 17 states. The more than 2000 comments generally focused on the quality and content of the characterization reports and on their intended use in region-to-area screening. These comments were paraphrased and grouped into 23 subjects within the following four topical areas: (1) General and Programmatic; (2) Geologic; (3) Environmental and Socioeconomic; and (4) Editorial. This document provides responses to the comments submitted by the states

  3. THE TRANSPARENCY IN THE REPORTING OF INTELLECTUAL CAPITAL: BETWEEN THE MANAGEMENT RESPONSIBILITY AND THE STAKEHOLDERS' REQUIREMENTS

    Directory of Open Access Journals (Sweden)

    Dicu Roxana-Manuela

    2011-07-01

    Full Text Available The increasingly ample orientation of the companies towards the intellectual capital is based on the rediscovery of this resource with (almost unlimited potential, generating economic benefits for a company. Given its importance, the information needs of stakeholders on this line have increased. Thus, in this context, it was put the issue of reporting information related to intellectual capital and the transparency of information published by companies, given that its reporting is not currently regulated. The objective of this paper is to establish an answer to a question: Up to what limit should be made public information related to this capital, given that stakeholders want as much information, and managers only publish information that favors the company's image? In addressing this issue, the point of departure is the intellectual capital structure, most commonly found in the literature, namely human capital, structural capital and relational capital. With this structure, the paper establishes, as a first step, a series of relevant indicators relating to the three components from three different perspectives: resources, management achievements and future expectations. At first observation, the indicators are divided into two categories: financial and non-financial, the first ones targeting the company's performance in relation to the components of intellectual capital, and the latter ones having a pronounced social touch. Based on these indicators, the paper analyses whether a company is willing to publish information, particularly those with social influence, especially in the current conditions of intensely requested social responsibility. In addition to documentary research, we also consider the most important findings based on existing reporting arrangements of the companies, especially from the reports published by them, depending on different criteria, such as social engagement, financial and accounting criteria etc. Given the lack of

  4. HSP70-Inducible hNIS-IRES-eGFP Reporter Imaging: Response to Heat Shock

    Directory of Open Access Journals (Sweden)

    Jiantu Che

    2007-11-01

    Full Text Available A retroviral vector pQHSP70/hNIS-IRES-eGFP (pQHNIG70 was constructed containing the hNIS-IRES-eGFP dual-reporter genes under the control of an inducible human heat shock protein (HSP70 promoter and RG2-pQHSP70/hNIS-IRES-eGFP (RG2-pQHNIG70 transduced cells were generated. Heat-induced expression of both reporter genes in RG2-pQHNIG70 cells was validated by enhanced green fluorescent protein (eGFP fluorescence-activated cell sorter, in vitro radiotracer assays, and immunoblot and immunocytochemistry. A 2.2- to 6.1-fold (131I−, a 6.1- to 14.4-fold (99mTcO4−, and a 5.1- to 39-fold (fluorescence increase above baseline was observed in response to graded hyperthermia (39–43°C. Increases in eGFP fluorescence and radiotracer uptake were first noted at 6 hours, reached a maximum at 24 hours, and fell toward baseline at 72 hours. A stable ratio of radiotracer uptake to eGFP fluorescence and to heat shock protein (HSP70 protein was demonstrated over a wide range of expression levels, induced by different levels of heating. We also demonstrate that the local application of heat on RG2-pQHNIG70 xenografts can effectively induce hNIS and eGFP gene expression in vivo and that this expression can be efficiently visualized by fluorescence, scintigraphic, and micro–positron emission tomography imaging. Endogenous HSP70 protein and reporter expression was confirmed by postmortem tissue evaluations (immunoblot and immunohistochemistry. The pQHNIG70 reporter system can be used to study stress and drug responses in transduced cells and tissues.

  5. Improving linear accelerator service response with a real- time electronic event reporting system.

    Science.gov (United States)

    Hoisak, Jeremy D P; Pawlicki, Todd; Kim, Gwe-Ya; Fletcher, Richard; Moore, Kevin L

    2014-09-08

    To track linear accelerator performance issues, an online event recording system was developed in-house for use by therapists and physicists to log the details of technical problems arising on our institution's four linear accelerators. In use since October 2010, the system was designed so that all clinical physicists would receive email notification when an event was logged. Starting in October 2012, we initiated a pilot project in collaboration with our linear accelerator vendor to explore a new model of service and support, in which event notifications were also sent electronically directly to dedicated engineers at the vendor's technical help desk, who then initiated a response to technical issues. Previously, technical issues were reported by telephone to the vendor's call center, which then disseminated information and coordinated a response with the Technical Support help desk and local service engineers. The purpose of this work was to investigate the improvements to clinical operations resulting from this new service model. The new and old service models were quantitatively compared by reviewing event logs and the oncology information system database in the nine months prior to and after initiation of the project. Here, we focus on events that resulted in an inoperative linear accelerator ("down" machine). Machine downtime, vendor response time, treatment cancellations, and event resolution were evaluated and compared over two equivalent time periods. In 389 clinical days, there were 119 machine-down events: 59 events before and 60 after introduction of the new model. In the new model, median time to service response decreased from 45 to 8 min, service engineer dispatch time decreased 44%, downtime per event decreased from 45 to 20 min, and treatment cancellations decreased 68%. The decreased vendor response time and reduced number of on-site visits by a service engineer resulted in decreased downtime and decreased patient treatment cancellations.

  6. Validity, reliability, and responsiveness of a self-reported foot and ankle score (SEFAS)

    Science.gov (United States)

    2012-01-01

    Background and purpose A questionnaire was introduced by the New Zealand Arthroplasty Registry for use when evaluating the outcome of total ankle replacement surgery. We evaluated the reliability, validity, and responsiveness of the modified Swedish version of the questionnaire (SEFAS) in patients with osteoarthritis or inflammatory arthritis before and/or after their ankle was replaced or fused. Patients and methods The questionnaire was translated into Swedish and cross-culturally adapted according to a standardized procedure. It was sent to 135 patients with ankle arthritis who were scheduled for or had undergone surgery, together with the foot and ankle outcome score (FAOS), the short form 36 (SF-36) score, and the EuroQol (EQ-5D) score. Construct validity was evaluated with Spearman’s correlation coefficient when comparing SEFAS with FAOS, SF-36, and EQ-5D, content validity by calculating floor and ceiling effects, test-retest reliability with intraclass correlation coefficient (ICC), internal consistency with Cronbach’s alpha (n = 62), agreement by Bland-Altman plot, and responsiveness by effect size and standardized response mean (n = 37). Results For construct validity, we correlated SEFAS with the other scores and 70% or more of our predefined hypotheses concerning correlations could be confirmed. There were no floor or ceiling effects. ICC was 0.92 (CI 95%: 0.88–0.95), Cronbach’s alpha 0.96, effect size was 1.44, and the standardized response mean was 1.00. Interpretation SEFAS is a self-reported foot and ankle score with good validity, reliability and responsiveness, indicating that the score can be used to evaluate patients with osteoarthritis or inflammatory arthritis of the ankle and outcome of surgery. PMID:22313352

  7. Report to Congress on status of emergency response planning for nuclear power plants

    International Nuclear Information System (INIS)

    1981-03-01

    This report responds to a request (Public Law 96-295, Section 109) for the Nuclear Regulatory Commission (NRC) to report to Congress on the status of emergency response planning in support of nuclear power reactors. The report includes information on the status of this planning as well as on the Commission actions relating to emergency preparedness. These actions include a summary of the new regulatory requirements and the preliminary results of two comprehensive Evacuation Time Estimate studies; one requested by the NRC including 50 nuclear power plant sites and one conducted by the Federal Emergency Management Agency (FEMA) for 12 high population density sites. FEMA provided the information in this report on the status of State and local planning, including projected schedules for joint State/county/licensee emergency preparedness exercises. Included as Appendicies are the NRC Emergency Planning Final Regulations, 10 CFR Part 50 (45 FR 55402), the FEMA Proposed Rule, 'Review and Approval of State and Local Radiological Emergency Plans and Preparedness', 44 CFR Part 350 (45 FR 42341) and the NRC/FEMA Memorandums of Understanding

  8. Responsible Development of Areva's Mining Activities - 2010 Report

    International Nuclear Information System (INIS)

    2011-07-01

    Areva's mining activities place it among the world leaders in uranium production. The main objective of Areva's mining activities is ensuring uranium supply over the long term to produce nuclear power while emitting less CO 2 , reducing risks to people and the environment and contributing to the development of areas where mining activities take place. Areva's mining activities span five continents. This diversified portfolio allows the group to carry out exploration, project development and production activities in various geopolitical and technological contexts with the support of its staff's multi-cultural backgrounds. This document is the first Responsible Development report of Areva's Mining Activities. Content: 1 - All about Areva's Mining Activities (Interview with Sebastien de Montessus, General Director of Areva's Mining Activities, Ongoing Progress, The Core of Areva's Mining Activities Work); 2 - The Foundation of Areva's Mining Activities Approach (Values and Principles, Governance, Commitments); 3 - Reporting on Areva's Mining Activities (Scope, Relevance of Indicators, Outlook); 4 - Being a Responsible Mining Stakeholder (Actions, Reducing Industrial Risks, Ensuring the Protection of Workers and Populations, Consuming Water and Energy Resources in a Rational Way, Preserving Biodiversity, Managing Waste Rock and Mine Tailings over Time, Sustainable Presence, Contribution to Social Development); 5 - Glossary

  9. Enhanced response inhibition during intensive meditation training predicts improvements in self-reported adaptive socioemotional functioning.

    Science.gov (United States)

    Sahdra, Baljinder K; MacLean, Katherine A; Ferrer, Emilio; Shaver, Phillip R; Rosenberg, Erika L; Jacobs, Tonya L; Zanesco, Anthony P; King, Brandon G; Aichele, Stephen R; Bridwell, David A; Mangun, George R; Lavy, Shiri; Wallace, B Alan; Saron, Clifford D

    2011-04-01

    We examined the impact of training-induced improvements in self-regulation, operationalized in terms of response inhibition, on longitudinal changes in self-reported adaptive socioemotional functioning. Data were collected from participants undergoing 3 months of intensive meditation training in an isolated retreat setting (Retreat 1) and a wait-list control group that later underwent identical training (Retreat 2). A 32-min response inhibition task (RIT) was designed to assess sustained self-regulatory control. Adaptive functioning (AF) was operationalized as a single latent factor underlying self-report measures of anxious and avoidant attachment, mindfulness, ego resilience, empathy, the five major personality traits (extroversion, agreeableness, conscientiousness, neuroticism, and openness to experience), difficulties in emotion regulation, depression, anxiety, and psychological well-being. Participants in Retreat 1 improved in RIT performance and AF over time whereas the controls did not. The control participants later also improved on both dimensions during their own retreat (Retreat 2). These improved levels of RIT performance and AF were sustained in follow-up assessments conducted approximately 5 months after the training. Longitudinal dynamic models with combined data from both retreats showed that improvement in RIT performance during training influenced the change in AF over time, which is consistent with a key claim in the Buddhist literature that enhanced capacity for self-regulation is an important precursor of changes in emotional well-being. PsycINFO Database Record (c) 2011 APA, all rights reserved.

  10. Responsible Development On Areva's Mining Activities. Report 2015

    International Nuclear Information System (INIS)

    2016-01-01

    Mining activities are the first link in the nuclear fuel cycle and in the integrated model of the Areva Group. Areva was one of the top producers worldwide in 2015, producing 11,002 metric tons of uranium. The group works to maintain resources and weighted reserves equivalent to 20 years of production at all times. Thanks to a presence spanning five continents, they ensure the long-term supply to customers of uranium for electricity production while maintaining a responsible attitude towards people and the environment. It has a diverse portfolio of both active mines (Canada, Kazakhstan and Niger) and mines under development (Africa). This document is Areva's Mining Activities responsible Development report for 2015. Content: profile (Overview, Keys events, Worldwide presence, Governance and Organization, Uranium market); CSR approach (Statement from the senior executive vice president, Risk management, Ethics and human rights, Voluntary initiatives, Materiality); Commitments (Health and radiation protection, Occupational safety, Environment and Biodiversity, Social involvement, Commitment to employees, Mining closure, Innovation); Performance (CSR objectives, Key indicators, Reporting parameters); Case Studies; Annexes (GRI Index)

  11. Responsible Development of Areva's Mining Activities. Report 2012

    International Nuclear Information System (INIS)

    2013-09-01

    This annual report, prepared by the Corporate Social Responsibility Department of Areva Mines, is the result of the mobilization of all our teams present at Areva's mining sites as well as those in Areva corporate support functions (compliance, sustainable development, etc). The data given cover the assets for which Areva acts as operator in uranium mining activities: exploration, project development, production and rehabilitation. The consolidated data target activities in France, Canada, Niger, Kazakhstan, Mongolia, Gabon and Namibia. Activities in the Central African Republic and those linked to La Mancha no longer fall within the scope of this report (sale of assets in 2012). By defining Areva's strategy and policies, this report aims to demonstrate Areva's performance in the key areas of mining activity responsibility: ethics and governance, social report, the environment, occupational health and safety, community involvement, commitments to stakeholders. This report is the third edition of this annual exercise. The results for Areva's main performance indicators are shown for the last three years (2010 to 2012). Some important information relates to the first half of 2013. Areva is a member of the International Council on Mining and Metals (ICMM). In this context, Areva's policies and commitments in terms of social responsibility are based on the ten sustainable development principles defined by the ICMM, as well as the associated 'position statement' documents. To this end, Areva's specialists are involved in the different working groups that bring together ICMM members to discuss the various sustainable development issues encountered in the extractive sector. Members of our top-level management form part of the Council of this organization. More generally, Areva has made a large number of commitments and works with professional organizations and international institutions. A file listing these various commitments is

  12. Bias in child maltreatment self-reports using interactive voice response (IVR).

    Science.gov (United States)

    Kepple, Nancy J; Freisthler, Bridget; Johnson-Motoyama, Michelle

    2014-10-01

    Few methods estimate the prevalence of child maltreatment in the general population due to concerns about socially desirable responding and mandated reporting laws. Innovative methods, such as interactive voice response (IVR), may obtain better estimates that address these concerns. This study examined the utility of interactive voice response (IVR) for child maltreatment behaviors by assessing differences between respondents who completed and did not complete a survey using IVR technology. A mixed-mode telephone survey was conducted in English and Spanish in 50 cities in California during 2009. Caregivers (n=3,023) self-reported abusive and neglectful parenting behaviors for a focal child under the age of 13 using computer-assisted telephone interviewing and IVR. We used hierarchical generalized linear models to compare survey completion by caregivers nested within cities for the full sample and age-specific ranges. For demographic characteristics, caregivers born in the United States were more likely to complete the survey when controlling for covariates. Parenting stress, provision of physical needs, and provision of supervisory needs were not associated with survey completion in the full multivariate model. For caregivers of children 0-4 years (n=838), those reporting they could often or always hear their child from another room had a higher likelihood of survey completion. The findings suggest IVR could prove to be useful for future surveys that aim to estimate abusive and/or neglectful parenting behaviors given the limited bias observed for demographic characteristics and problematic parenting behaviors. Further research should expand upon its utility to advance estimation rates. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. Steroid responsive encephalopathy associated with autoimmune thyroiditis following ipilimumab therapy: a case report.

    Science.gov (United States)

    Carl, David; Grüllich, Carsten; Hering, Steffen; Schabet, Martin

    2015-07-26

    Ipilimumab is a cytotoxic T-lymphocyte-associated protein 4 receptor antibody used for immunotherapy in cancer. Several immune-related adverse events are known. Steroid responsive encephalopathy associated with autoimmune thyroiditis is an autoimmune encephalopathy associated with Hashimoto's Disease and elevated serum levels of the related antibodies (anti-thyroid-peroxidase antibody or anti-thyroglobulin antibody). Our case implies that steroid responsive encephalopathy associated with autoimmune thyroiditis may be another previously unreported side effect of ipilimumab therapy. We report the case of a 64 years old caucasian patient with prostatic cancer who received ipilimumab therapy in a clinical trial. He presented with aphasia, tremor and ataxia, myocloni, hallucinations, anxiety and agitation in turns with somnolence. Cranial nerves, deep tendon reflexes, motor and sensory functions were normal. Electroencephalography showed background slowing but no epileptic discharges. Brain magnetic resonance imaging was normal and showed no signs of hypophysitis. Cerebrospinal fluid findings ruled out infection and neoplastic meningitis. Anti-thyroid antibodies (anti-thyroid-peroxidase antibody and anti-thyroglobulin antibody) were heavily increased. Assuming steroid responsive encephalopathy associated with autoimmune thyroiditis the patient was treated with 1,000 mg methylprednisolone i.v. for 3 days and continued with 1 mg/kg orally. On the 3rd day of treatment the patient's condition started to improve. Within the next few days he gradually returned to his previous state, and electroencephalography eventually showed only slight slowing. Seven months later the patient's condition was stable, and anti-thyroid antibodies were no more detectable. Steroid responsive encephalopathy associated with autoimmune thyroiditis may be a hitherto unrecognized complication of ipililumab treatment and should be taken into consideration in patients developing central nervous

  14. Physiological responses to multiple speed treadmill walking for Syme vs. transtibial amputation--a case report.

    Science.gov (United States)

    Lin-Chan, S; Nielsen, D H; Shurr, D G; Saltzman, C L

    2003-12-02

    To date, there have been no longitudinal studies comparing walking at different levels of amputation. The objective of this study was to compare the self-selected walking velocity (SSWV) and selected physiologic variables during walking between a Syme and a later transtibial level of amputation for a single subject. Additional comparison was made between the SACH foot prosthesis and a dynamic response foot prosthesis. A 35-year-old male with a traumatic Syme amputation later underwent elective transtibial amputation. SSWV and multiple speed treadmill walking tests (53.64, 67.05, 80.46, 93.87 and 107.28 m/min) were evaluated under three conditions (Syme prosthesis with SACH foot, transtibial prosthesis with SACH foot, and transtibial prosthesis with Flex-Foot). Walking with transtibial prosthesis showed minimal differences in oxygen consumption (0 - 5% reduction), heart rate response (0 - 1% reduction), or gait efficiency (0 - 5% improvement) across all speeds when compared with Syme prosthesis (both with SACH foot). However, the SSWV was 6 - 8% faster for the transtibial SACH foot. Walking with transtibial Flex-Foot required less cardiovascular demand than with transtibial SACH foot at higher speeds. In this case report, it seemed that transtibial amputation did not have adverse effects on selected physiological responses at a variety of walking speeds when compared to Syme amputation, and that the use of a dynamic response foot enhanced his gait performance. Further experimental studies involving more subjects with traumatic Syme and transtibial amputations are required to better understand the effect of these two levels of amputation on energy cost of walking.

  15. Understanding the Response of Photosynthetic Metabolism in Tropical Forests to Seasonal Climate Variations. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Dye, Dennis [U.S. Geological Survey, Menlo Park, CA (United States); Ivanov, Valeriy [Univ. of Michigan, Ann Arbor, MI (United States); Saleska, Scott [Univ. of Arizona, Tucson, AZ (United States); Huete, Alfredo [Univ. of Arizona, Tucson, AZ (United States); Univ. of Technology, Sydney NSW (Australia)

    2017-03-31

    This U.S-Brazil collaboration for GOAmazon has investigated a deceptively simple question: what controls the response of photosynthesis in Amazon tropical forests to seasonal variations in climate? In the past this question has been difficult to answer with modern earth system process models. We hypothesized that observed dry season increases in photosynthetic capacity are controlled by the phenology of leaf flush and litter fall, from which the seasonal pattern of LAI emerges. Our results confirm this hypothesis (Wu et al., 2016). Synthesis of data collected throughout the 3-year project period continues through December 31, 2017 under no-cost extensions granted to the project teams at University of Michigan and University of Arizona (Award 2). The USGS component (Award 1) ceased on the final date of the project performance period, December 31, 2016. This report summarizes the overall activities and achievements of the project, and constitutes the final project report for the USGS component. The University of Michigan will submit a separate final report that includes additional results and deliverables achieved during the period of their and the University of Arizona’s no-cost extension, which will end on December 31, 2017.

  16. Dentist attitudes and responsibilities concerning child sexual abuse. A review and a case report.

    Science.gov (United States)

    Garrocho-Rangel, Arturo; Márquez-Preciado, Raúl; Olguín-Vivar, Ana-Isabel; Ruiz-Rodríguez, Socorro; Pozos-Guillén, Amaury

    2015-07-01

    According to the World Health Organization, child abuse and neglect is "every kind of physical, sexual, emotional abuse, neglect or negligent treatment, commercial or other exploitation resulting in actual or potential harm to the child's health, survival, development or dignity in the context of a relationship of responsibility, trust or power". The aim of the present report is to inform about the most relevant aspects of child abuse and the characteristics of injuries to the head, neck, and orofacial regions, in addition to the suggested role of, and management by, the dentist for the evaluation of this condition, and also for reporting a case of a physically and sexually abused girl aged 5 years 8 months. Throughout the appointments, some type of abuse in this patient was suspected by the treating dentists at the clinic, mainly due to the initial behavior exhibited by the patient in the dental chair. Based on the clinical diagnostic an intensive preventive plan and restorative treatment was realized. The timely detection of the signs and symptoms of sexual abuse, often present in the orofacial region, place the pediatric dentist in a strategic situation, with the capacity to recognize, register, and later report those cases considered as suspect, including the dental treatment delivered and the intensive behavioral-psychological management, in order to achieve acceptation by the otherwise very anxious patient of the indicated restorative and preventive dental procedures. Key words:Child abuse, dentistry, behavior management.

  17. Watershed evaluation and habitat response to recent storms; annual report for 1999

    International Nuclear Information System (INIS)

    Rhodes, Jonathan J.; Huntington, Charles W.

    2000-01-01

    Large and powerful storm systems moved through the Pacific Northwest during the wet season of 1995--96, triggering flooding, mass erosion, and, alteration of salmon habitats in affected watersheds. This project study was initiated to assess whether watershed conditions are causing damage, triggered by storm events, to salmon habitat on public lands in the Snake River basin. The storms and flooding in 1995--96 provide a prime opportunity to examine whether habitat conditions are improving, because the effects of land management activities on streams and salmon habitat are often not fully expressed until triggered by storms and floods. To address these issues, they are studying the recent storm responses of watersheds and salmon habitat in systematically selected subbasins and watersheds within the Snake River system. The study watersheds include several in the Wenaha and Tucannon subbasins in Washington and Oregon, and the watersheds of Squaw Creek (roaded) and Weir Creek (unroaded) in the Lochsa River subbasin, Idaho. The study was designed to examine possible differences in the effects of the storms in broadly comparable watersheds with differing magnitudes or types of disturbance. Watershed response is examined by comparing storm response mechanisms, such as rates of mass failure, among watersheds with similar attributes, but different levels of land management. The response of salmon habitat conditions is being examined by comparing habitat conditions before and after the storms in a stream and among streams in watersheds with similar attributes but different levels of land management. If appropriate to the results, the study will identify priority measures for reducing the severity of storm responses in watersheds within the Snake River Basin with habitat for at-risk salmon. This annual report describes the attributes of the study watersheds and the criteria and methods used to select them. The report also describes the watershed and fish habitat attributes

  18. Watershed Evaluation and Habitat Response to Recent Storms : Annual Report for 1999.

    Energy Technology Data Exchange (ETDEWEB)

    Rhodes, Jonathan J.; Huntington, Charles W.

    2000-02-01

    Large and powerful storm systems moved through the Pacific Northwest during the wet season of 1995--96, triggering flooding, mass erosion, and, alteration of salmon habitats in affected watersheds. This project study was initiated to assess whether watershed conditions are causing damage, triggered by storm events, to salmon habitat on public lands in the Snake River basin. The storms and flooding in 1995--96 provide a prime opportunity to examine whether habitat conditions are improving, because the effects of land management activities on streams and salmon habitat are often not fully expressed until triggered by storms and floods. To address these issues, they are studying the recent storm responses of watersheds and salmon habitat in systematically selected subbasins and watersheds within the Snake River system. The study watersheds include several in the Wenaha and Tucannon subbasins in Washington and Oregon, and the watersheds of Squaw Creek (roaded) and Weir Creek (unroaded) in the Lochsa River subbasin, Idaho. The study was designed to examine possible differences in the effects of the storms in broadly comparable watersheds with differing magnitudes or types of disturbance. Watershed response is examined by comparing storm response mechanisms, such as rates of mass failure, among watersheds with similar attributes, but different levels of land management. The response of salmon habitat conditions is being examined by comparing habitat conditions before and after the storms in a stream and among streams in watersheds with similar attributes but different levels of land management. If appropriate to the results, the study will identify priority measures for reducing the severity of storm responses in watersheds within the Snake River Basin with habitat for at-risk salmon. This annual report describes the attributes of the study watersheds and the criteria and methods used to select them. The report also describes the watershed and fish habitat attributes

  19. The effect of a workflow-based response system on hospital-wide voluntary incident reporting rates.

    Science.gov (United States)

    Wang, Szu-Chang; Li, Ying-Chun; Huang, Hung-Chi

    2013-02-01

    Hospital incident reporting systems are usually evaluated on their theoretical benefit to the hospital or increase in reporting rates alone. To evaluate a workflow-based response system on staff incident reporting rates. A prospective cohort study of incident reports made by staff members before (2006-2007) and after (2008-2009) the system was implemented on 1 January 2008 at a medical center in southern Taiwan. Pre-system and post-system data were based on 713 129 and 730 176 inpatient days and 160 692 and 168 850 emergency department visits. The addition of a workflow-based response system to a reporting system processing incident reports and intra-hospital responses. Voluntary incident reporting rates and distribution of incident severities. Inpatient reports [9.9 vs. 28.8 per 10 000 patient days; rate ratio (RR): 2.9, 95% confidence interval (CI): 2.7-3.2, P reports (5.9 vs. 19.2 per 10 000 visits, RR: 3.3, 95% CI: 2.6-4.1, P system reported incidents were more evenly distributed over five severity levels than pre-sytem incidents, moving more toward the very severe level (RR: 17.6, 95% CI: 8.4-37.0, P system to the hospital incident reporting system significantly increased hospital-wide voluntary incident report rates at all incident injury levels.

  20. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A lymphocytic reactive response of the central nervous system? A case report.

    Science.gov (United States)

    Wang, Xiaolin; Huang, Dehui; Huang, Xusheng; Zhang, Jiatang; Ran, Ye; Lou, Xin; Gui, Qiuping; Yu, Shengyuan

    2017-04-15

    Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroid (CLIPPERS) was first described in 2010. The characteristic clinical picture, radiological distribution and steroid response have been well-described in previous reports. However, the underlying pathogenesis and nosological position of CLIPPERS in the CNS require further investigation for the primary CNS lymphoma have been identified by autopsy subsequently. Here, we report a 51-year-old woman who was diagnosed with CLIPPERS but progressed to primary CNS lymphomatoid granulomatosis, which supports that CLIPPERS is not just an inflammatory CNS disorder. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Emancipatory accounting in China:does alternative social reporting of non-governmental organisations address corporate social responsibility problems?

    OpenAIRE

    Shen, Dan

    2014-01-01

    With the increasing number of corporate scandals such as Enron, Corporate Social Responsibility (CSR) movement has become a global phenomenon and attracted ever more attention nowadays. Although a large number of corporations have begun to choose corporate social reporting to provide social and environmental information for proclaiming their social responsibilities, corporate social reporting is widely regarded as a public relation opportunity to respond to social pressures. Treating corporat...

  2. Traces of unconscious mental processes in introspective reports and physiological responses.

    Directory of Open Access Journals (Sweden)

    Leonid Ivonin

    Full Text Available Unconscious mental processes have recently started gaining attention in a number of scientific disciplines. One of the theoretical frameworks for describing unconscious processes was introduced by Jung as a part of his model of the psyche. This framework uses the concept of archetypes that represent prototypical experiences associated with objects, people, and situations. Although the validity of Jungian model remains an open question, this framework is convenient from the practical point of view. Moreover, archetypes found numerous applications in the areas of psychology and marketing. Therefore, observation of both conscious and unconscious traces related to archetypal experiences seems to be an interesting research endeavor. In a study with 36 subjects, we examined the effects of experiencing conglomerations of unconscious emotions associated with various archetypes on the participants' introspective reports and patterns of physiological activations. Our hypothesis for this experiment was that physiological data may predict archetypes more precisely than introspective reports due to the implicit nature of archetypal experiences. Introspective reports were collected using the Self-Assessment Manikin (SAM technique. Physiological measures included cardiovascular, electrodermal, respiratory responses and skin temperature of the subjects. The subjects were stimulated to feel four archetypal experiences and four explicit emotions by means of film clips. The data related to the explicit emotions served as a reference in analysis of archetypal experiences. Our findings indicated that while prediction models trained on the collected physiological data could recognize the archetypal experiences with accuracy of 55 percent, similar models built based on the SAM data demonstrated performance of only 33 percent. Statistical tests enabled us to confirm that physiological observations are better suited for observation of implicit psychological constructs

  3. Traces of Unconscious Mental Processes in Introspective Reports and Physiological Responses

    Science.gov (United States)

    Ivonin, Leonid; Chang, Huang-Ming; Diaz, Marta; Catala, Andreu; Chen, Wei; Rauterberg, Matthias

    2015-01-01

    Unconscious mental processes have recently started gaining attention in a number of scientific disciplines. One of the theoretical frameworks for describing unconscious processes was introduced by Jung as a part of his model of the psyche. This framework uses the concept of archetypes that represent prototypical experiences associated with objects, people, and situations. Although the validity of Jungian model remains an open question, this framework is convenient from the practical point of view. Moreover, archetypes found numerous applications in the areas of psychology and marketing. Therefore, observation of both conscious and unconscious traces related to archetypal experiences seems to be an interesting research endeavor. In a study with 36 subjects, we examined the effects of experiencing conglomerations of unconscious emotions associated with various archetypes on the participants’ introspective reports and patterns of physiological activations. Our hypothesis for this experiment was that physiological data may predict archetypes more precisely than introspective reports due to the implicit nature of archetypal experiences. Introspective reports were collected using the Self-Assessment Manikin (SAM) technique. Physiological measures included cardiovascular, electrodermal, respiratory responses and skin temperature of the subjects. The subjects were stimulated to feel four archetypal experiences and four explicit emotions by means of film clips. The data related to the explicit emotions served as a reference in analysis of archetypal experiences. Our findings indicated that while prediction models trained on the collected physiological data could recognize the archetypal experiences with accuracy of 55 percent, similar models built based on the SAM data demonstrated performance of only 33 percent. Statistical tests enabled us to confirm that physiological observations are better suited for observation of implicit psychological constructs like archetypes

  4. Traces of unconscious mental processes in introspective reports and physiological responses.

    Science.gov (United States)

    Ivonin, Leonid; Chang, Huang-Ming; Diaz, Marta; Catala, Andreu; Chen, Wei; Rauterberg, Matthias

    2015-01-01

    Unconscious mental processes have recently started gaining attention in a number of scientific disciplines. One of the theoretical frameworks for describing unconscious processes was introduced by Jung as a part of his model of the psyche. This framework uses the concept of archetypes that represent prototypical experiences associated with objects, people, and situations. Although the validity of Jungian model remains an open question, this framework is convenient from the practical point of view. Moreover, archetypes found numerous applications in the areas of psychology and marketing. Therefore, observation of both conscious and unconscious traces related to archetypal experiences seems to be an interesting research endeavor. In a study with 36 subjects, we examined the effects of experiencing conglomerations of unconscious emotions associated with various archetypes on the participants' introspective reports and patterns of physiological activations. Our hypothesis for this experiment was that physiological data may predict archetypes more precisely than introspective reports due to the implicit nature of archetypal experiences. Introspective reports were collected using the Self-Assessment Manikin (SAM) technique. Physiological measures included cardiovascular, electrodermal, respiratory responses and skin temperature of the subjects. The subjects were stimulated to feel four archetypal experiences and four explicit emotions by means of film clips. The data related to the explicit emotions served as a reference in analysis of archetypal experiences. Our findings indicated that while prediction models trained on the collected physiological data could recognize the archetypal experiences with accuracy of 55 percent, similar models built based on the SAM data demonstrated performance of only 33 percent. Statistical tests enabled us to confirm that physiological observations are better suited for observation of implicit psychological constructs like archetypes than

  5. Management by Trajectory Trade Study of Roles and Responsibilities Between Participants and Automation Report

    Science.gov (United States)

    Fernandes, Alicia D.; Kaler, Curt; Leiden, Kenneth; Atkins, Stephen; Bell, Alan; Kilbourne, Todd; Evans, Mark

    2017-01-01

    This report describes a trade study of roles and responsibilities associated with the Management by Trajectory (MBT) concept. The MBT concept describes roles, responsibilities, and information and automation requirements for providing air traffic controllers and managers the ability to quickly generate, evaluate and implement changes to an aircraft's trajectory. In addition, the MBT concept describes mechanisms for imposing constraints on flight operator preferred trajectories only to the extent necessary to maintain safe and efficient traffic flows, and the concept provides a method for the exchange of trajectory information between ground automation systems and the aircraft that allows for trajectory synchronization and trajectory negotiation. The participant roles considered in this trade study include: airline dispatcher, flight crew, radar controller, traffic manager, and Air Traffic Control System Command Center (ATCSCC) traffic management specialists. The proposed allocation of roles and responsibilities was based on analysis of several use cases that were developed for this purpose as well as for walking through concept elements. The resulting allocation of roles and responsibilities reflects both increased automation capability to support many aviation functions, as well as increased flexibility to assign responsibilities to different participants - in many cases afforded by the increased automation capabilities. Note that the selection of participants to consider for allocation of each function is necessarily rooted in the current environment, in that MBT is envisioned as an evolution of the National Airspace System (NAS), and not a revolution. A key feature of the MBT allocations is a vision for the traffic management specialist to take on a greater role. This is facilitated by the vision that separation management functions, in addition to traffic management functions, will be carried out as trajectory management functions. This creates an opportunity

  6. Applications of Multidimensional Item Response Theory Models with Covariates to Longitudinal Test Data. Research Report. ETS RR-16-21

    Science.gov (United States)

    Fu, Jianbin

    2016-01-01

    The multidimensional item response theory (MIRT) models with covariates proposed by Haberman and implemented in the "mirt" program provide a flexible way to analyze data based on item response theory. In this report, we discuss applications of the MIRT models with covariates to longitudinal test data to measure skill differences at the…

  7. Responsive copolymers for enhanced petroleum recovery. Quarterly technical progress report, September 11, 1994--December 22, 1994

    Energy Technology Data Exchange (ETDEWEB)

    McCormick, C.; Hester, R.

    1994-01-01

    Advanced polymer systems that possess microstructural features that are responsive to temperature, electrolyte concentration, and shear conditions are being synthesized which will be superior to polymers presently used for mobility control in enhanced oil recovery. Improved polymer performance is accomplished by controlling hydrophobic or ampholytic interations between individual polymer chains in solution. The advanced polymers will circumbent major problems inherent in conventional EOR polymers in which molecular weight is usually compromised to allow sufficient solution viscosity and uniform reservoir permeation without plugging the porous media. Accomplishments are reported for the following tasks: quaternary ammonium cyclopolymer synthesis; characterization of molecular structure and solution behavior; {sup 23}Na NMR studies of non-binding to anionic polyelectrolytes and solution rheology.

  8. [Myasthenia gravis with the electrographic response of a myasthenic syndrome. Report of a case].

    Science.gov (United States)

    Werneck, L C; Bittencourt, P C; Nóvak, E M

    1985-06-01

    It is reported a case of a 61 years-old man with progressive asthenia, disfagia, disphonia and diplopia, of variable intensity during the day, who had a very good response to anticolinesterasic drugs and corticosteroids. The repetitive stimulation tests at low frequency, resulted in large increment (maximum 275%) of the basal voltage after exercise. At high frequency he also had a large increment. Radiological and laboratory investigation three times in a seven-year period was normal, without evidence of any neoplasia. Muscle biopsy showed a type II muscle fiber atrophy. The repetitive stimulation tests repeated three times, was typical of myasthenia gravis in one occasion and in the other two, typical of myasthenic syndrome (increment of 418%). A discussion about other cases with similar findings is made after a review of the literature.

  9. Fast Response, Load-Matching Hybrid Fuel Cell: Final Technical Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Key, T. S.; Sitzlar, H. E.; Geist, T. D.

    2003-06-01

    Hybrid DER technologies interconnected with the grid can provide improved performance capabilities compared to a single power source, and, add value, when matched to appropriate applications. For example, in a typical residence, the interconnected hybrid system could provide power during a utility outage, and also could compensate for voltage sags in the utility service. Such a hybrid system would then function as a premium power provider and eliminate the potential need for an uninterruptible power supply. In this research project, a proton exchange membrane (PEM) fuel cell is combined with an asymmetrical ultracapacitor to provide robust power response to changes in system loading. This project also considers the potential of hybrid DER technologies to improve overall power system compatibility and performance. This report includes base year accomplishments of a proposed 3-year-option project.

  10. Internal control and auditing – a necessity for responsible reporting and managerial usefulness of accounting information

    Directory of Open Access Journals (Sweden)

    Alina-Teodora CIUHUREANU

    2016-12-01

    Full Text Available It is well known that not only in Romania, internal control and auditing are subject to legal regulations. Often, the two forms of ensuring the quality of accounting information are particularly perceived as mandatory requirement instead of as a necessity for certifying the information travelling between producer and user. The paper addresses issues which aim to highlight the need to organize the internal control and auditing of the accounting information from the perspective of the need to certify the accounting information for a responsible reporting. Moreover, through a study conducted on a sample of 301 companies in the Central Region of Romania, we also captured the managers’/directors’ opinion regarding the internal control and audit in terms of confidence, ensuring opportunities to valorise the accounting information and its usefulness for management.

  11. Red Lake Band of Chippewa Indians response to the draft area recommendation report

    International Nuclear Information System (INIS)

    1986-01-01

    The statement of Little Rock, a Chief of the Red Lake Band of Chippewa Indians, provides the genesis of the Red Lake Band of Chippewa Indian's response to the Department of Energy's efforts to establish a nuclear waste repository on lands ceded under the Treaty of 1863. Of paramount interest to the Red Lake Band of Chippewa Indians are the unresolved issues of hunting and fishing rights, promised in the Treaty negotiations of 1863 and still unresolved to the satisfaction of Tribal members. Comments pertaining to the draft Area Recommendation Report will address the potential impact of a high-level nuclear repository on the human and natural resources of the Red Lake Band of Chippewa Indians. Socio-cultural factors of economics and family displacement and traditional beliefs, combined with potential hazards to natural habitats of wildlife, will be analyzed and synthesized for applicable conclusions. 18 refs., 4 tabs

  12. Bayesian Analysis of Item Response Curves. Research Report 84-1. Mathematical Sciences Technical Report No. 132.

    Science.gov (United States)

    Tsutakawa, Robert K.; Lin, Hsin Ying

    Item response curves for a set of binary responses are studied from a Bayesian viewpoint of estimating the item parameters. For the two-parameter logistic model with normally distributed ability, restricted bivariate beta priors are used to illustrate the computation of the posterior mode via the EM algorithm. The procedure is illustrated by data…

  13. The Cortisol Response to Anticipated Intergroup Interactions Predicts Self-Reported Prejudice

    Science.gov (United States)

    Bijleveld, Erik; Scheepers, Daan; Ellemers, Naomi

    2012-01-01

    Objectives While prejudice has often been shown to be rooted in experiences of threat, the biological underpinnings of this threat–prejudice association have received less research attention. The present experiment aims to test whether activations of the hypothalamus-pituitary-adrenal (HPA) axis, due to anticipated interactions with out-group members, predict self-reported prejudice. Moreover, we explore potential moderators of this relationship (i.e., interpersonal similarity; subtle vs. blatant prejudice). Methodology/Principal findings Participants anticipated an interaction with an out-group member who was similar or dissimilar to the self. To index HPA activation, cortisol responses to this event were measured. Then, subtle and blatant prejudices were measured via questionnaires. Findings indicated that only when people anticipated an interaction with an out-group member who was dissimilar to the self, their cortisol response to this event significantly predicted subtle (r = .50) and blatant (r = .53) prejudice. Conclusions These findings indicate that prejudicial attitudes are linked to HPA-axis activity. Furthermore, when intergroup interactions are interpreted to be about individuals (and not so much about groups), experienced threat (or its biological substrate) is less likely to relate to prejudice. This conclusion is discussed in terms of recent insights from social neuroscience. PMID:22442709

  14. The cortisol response to anticipated intergroup interactions predicts self-reported prejudice.

    Directory of Open Access Journals (Sweden)

    Erik Bijleveld

    Full Text Available OBJECTIVES: While prejudice has often been shown to be rooted in experiences of threat, the biological underpinnings of this threat-prejudice association have received less research attention. The present experiment aims to test whether activations of the hypothalamus-pituitary-adrenal (HPA axis, due to anticipated interactions with out-group members, predict self-reported prejudice. Moreover, we explore potential moderators of this relationship (i.e., interpersonal similarity; subtle vs. blatant prejudice. METHODOLOGY/PRINCIPAL FINDINGS: Participants anticipated an interaction with an out-group member who was similar or dissimilar to the self. To index HPA activation, cortisol responses to this event were measured. Then, subtle and blatant prejudices were measured via questionnaires. Findings indicated that only when people anticipated an interaction with an out-group member who was dissimilar to the self, their cortisol response to this event significantly predicted subtle (r = .50 and blatant (r = .53 prejudice. CONCLUSIONS: These findings indicate that prejudicial attitudes are linked to HPA-axis activity. Furthermore, when intergroup interactions are interpreted to be about individuals (and not so much about groups, experienced threat (or its biological substrate is less likely to relate to prejudice. This conclusion is discussed in terms of recent insights from social neuroscience.

  15. The cortisol response to anticipated intergroup interactions predicts self-reported prejudice.

    Science.gov (United States)

    Bijleveld, Erik; Scheepers, Daan; Ellemers, Naomi

    2012-01-01

    While prejudice has often been shown to be rooted in experiences of threat, the biological underpinnings of this threat-prejudice association have received less research attention. The present experiment aims to test whether activations of the hypothalamus-pituitary-adrenal (HPA) axis, due to anticipated interactions with out-group members, predict self-reported prejudice. Moreover, we explore potential moderators of this relationship (i.e., interpersonal similarity; subtle vs. blatant prejudice). Participants anticipated an interaction with an out-group member who was similar or dissimilar to the self. To index HPA activation, cortisol responses to this event were measured. Then, subtle and blatant prejudices were measured via questionnaires. Findings indicated that only when people anticipated an interaction with an out-group member who was dissimilar to the self, their cortisol response to this event significantly predicted subtle (r = .50) and blatant (r = .53) prejudice. These findings indicate that prejudicial attitudes are linked to HPA-axis activity. Furthermore, when intergroup interactions are interpreted to be about individuals (and not so much about groups), experienced threat (or its biological substrate) is less likely to relate to prejudice. This conclusion is discussed in terms of recent insights from social neuroscience.

  16. Response Bias and the Personality Inventory for DSM-5: Contrasting Self- and Informant-Report.

    Science.gov (United States)

    Quilty, Lena C; Cosentino, Nicole; Bagby, R Michael

    2017-04-03

    Previous research has raised concerns that scores derived from the Personality Inventory for DSM-5 (PID-5; American Psychiatric Association, 2013; Krueger, Derringer, Markon, Watson, & Skodol, 2012) may be compromised by response styles such as underreporting or overreporting. The informant-report form of the PID-5 (PID-5-IRF; Markon, Quilty, Bagby, & Krueger, 2013) has been recommended for use when response bias is an assessment concern. The purpose of the current investigation was to evaluate PID-5 and PID-5-IRF scale score elevations across participants exhibiting signs of overreporting or underreporting. A total of 245 adults completed the PID-5 and the Revised NEO Personality Inventory (NEO PI-R; Costa & McCrae, 1992). A family member or friend of at least 1 year's acquaintance completed the PID-5-IRF for 216 of these. A total of 211 target-informant pairs were available for analysis. Participants were categorized as overreporting and underreporting according to NEO PI-R validity scale cutoffs. The majority of PID-5 scale scores were elevated in those identified as overreporting; more than half of the PID-5-IRF scale scores were similarly elevated. The majority of PID-5 scale scores were lower in those scoring above underreporting cut-offs; however, PID-5-IRF scales were not as consistently or strongly impacted. PID-5 scales were strongly impacted by response bias, whereas PID-5-IRF scores were less strongly impacted overall, and more so by overreporting bias. Caution when using these instruments in the assessment of personality disorders prone to over- or underreporting may be warranted. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  17. Metastatic colorectal cancer responsive to regorafenib for 2 years: a case report.

    Science.gov (United States)

    Yoshino, Kenji; Manaka, Dai; Kudo, Ryo; Kanai, Shunpei; Mitsuoka, Eisei; Kanto, Satoshi; Hamasu, Shinya; Konishi, Sayuri; Nishitai, Ryuta

    2017-08-18

    Regorafenib is an oral multikinase inhibitor that has been demonstrated as clinically effective in patients with metastatic colorectal cancer in phase III studies. Although disease control was achieved in 40% of the pretreated patients with metastatic colorectal cancer in the pivotal studies, radiological response has rarely been reported. Severe adverse events associated with regorafenib are known to occur during the first and second courses of treatment. We present a case of a 62-year-old Japanese patient whose metastatic colorectal cancer has been responding to treatment with regorafenib for 2 years. A 54-year-old Japanese man visited our institute exhibiting general malaise, and he was diagnosed with ascending colon cancer in April 2006. He underwent right hemicolectomy, and the final staging was T3N0M0, stage II. After 19 months, pulmonary metastasis and anastomotic recurrences were detected, and a series of operations were performed to resect both metastatic lesions. After that, liver metastasis, a duodenal metastasis with right renal invasion, right adrenal metastasis, and para-aortic lymph node metastases were observed during follow-up, and chemotherapy and resection were performed. The patient had metastatic para-aortic lymph nodes after the fifth tumor resection and underwent multiple lines of chemotherapy in April 2014. Regorafenib monotherapy was started at 80 mg/day. Then, regorafenib was increased to 120 mg/day in the second cycle. Regorafenib monotherapy led to 60% tumor shrinkage within the initial 2 months, and the tumor further decreased in size over 4 months until it became unrecognizable on imaging studies. The clinical effects of regorafenib monotherapy have shown a partial response according to Response Evaluation Criteria in Solid Tumors criteria. No severe adverse events were observed, except for mild fatigue and hand-foot syndrome. The patient has received 24 courses of regorafenib over 2 years without exhibiting tumor progression. To the

  18. Bupropion for the treatment of fluoxetine non-responsive trichotillomania: a case report

    Directory of Open Access Journals (Sweden)

    Bipeta Rajshekhar

    2011-11-01

    Full Text Available Abstract Introduction Trichotillomania, classified as an impulse control disorder in the Diagnostic and Statistical Manual of Mental Disorders, is characterized by the recurrent pulling out of one's hair, resulting in noticeable hair loss. The condition has a varied etiology. Specific serotonin reuptake inhibitors are considered the treatment of choice; however some patients fail to respond to this class of drugs. A few older reports suggest possible benefit from treatment with bupropion. Case presentation A 23-year-old Asian woman with fluoxetine non- responsive trichotillomania was treated with sustained release bupropion (up to 450 mg/day and cognitive behavior therapy. She demonstrated clinically significant improvement on the Clinical Global Impression - Improvement scale by week 13. The improvement persisted throughout the 12-month follow-up period. Conclusions The present case report may be of interest to psychiatrists and dermatologists. Apart from the serotonergic pathway, others, such as the mesolimbic pathway, also appear to be involved in the causation of trichotillomania. Bupropion may be considered as an alternative pharmacological treatment for patients who do not respond to specific serotonin reuptake inhibitors. However, this initial finding needs to be confirmed by well designed double-blind placebo controlled trials.

  19. Exposure to wind turbine noise: Perceptual responses and reported health effects.

    Science.gov (United States)

    Michaud, David S; Feder, Katya; Keith, Stephen E; Voicescu, Sonia A; Marro, Leonora; Than, John; Guay, Mireille; Denning, Allison; McGuire, D'Arcy; Bower, Tara; Lavigne, Eric; Murray, Brian J; Weiss, Shelly K; van den Berg, Frits

    2016-03-01

    Health Canada, in collaboration with Statistics Canada, and other external experts, conducted the Community Noise and Health Study to better understand the impacts of wind turbine noise (WTN) on health and well-being. A cross-sectional epidemiological study was carried out between May and September 2013 in southwestern Ontario and Prince Edward Island on 1238 randomly selected participants (606 males, 632 females) aged 18-79 years, living between 0.25 and 11.22 km from operational wind turbines. Calculated outdoor WTN levels at the dwelling reached 46 dBA. Response rate was 78.9% and did not significantly differ across sample strata. Self-reported health effects (e.g., migraines, tinnitus, dizziness, etc.), sleep disturbance, sleep disorders, quality of life, and perceived stress were not related to WTN levels. Visual and auditory perception of wind turbines as reported by respondents increased significantly with increasing WTN levels as did high annoyance toward several wind turbine features, including the following: noise, blinking lights, shadow flicker, visual impacts, and vibrations. Concern for physical safety and closing bedroom windows to reduce WTN during sleep also increased with increasing WTN levels. Other sample characteristics are discussed in relation to WTN levels. Beyond annoyance, results do not support an association between exposure to WTN up to 46 dBA and the evaluated health-related endpoints.

  20. Adolescents with psychopathic traits report reductions in physiological responses to fear.

    Science.gov (United States)

    Marsh, Abigail A; Finger, Elizabeth C; Schechter, Julia C; Jurkowitz, Ilana T N; Reid, Marguerite E; Blair, R J R

    2011-08-01

    Psychopathy is characterized by profound affective deficits, including shallow affect and reduced empathy. Recent research suggests that these deficits may apply particularly to negative emotions, or to certain negative emotions such as fear. Despite increased focus on the cognitive and neural underpinnings of psychopathy, little is known about how psychopathy is associated with emotional deficits across a range of emotions. In addition, the relationship between psychopathy and the subjective experience of emotion has not yet been assessed.   Eighteen 10-17-year-olds with psychopathic traits and 24 comparison children and adolescents reported on their subjective experiences of emotion during five recent emotionally evocative life events, following a paradigm developed by Scherer and colleagues (Scherer & Wallbott, 1994). Group comparisons were then performed to assess variations in subjective experiences across emotions. As predicted, psychopathy was associated with reductions in the subjective experience of fear relative to other emotions. Children and adolescents with psychopathic traits reported fewer symptoms associated with sympathetic nervous system arousal during fear-evoking experiences. Rather than being related to uniformly impoverished emotional experience, psychopathic traits appear to be associated with greater deficits in subjective experiences of fear. This pattern of responding supports and extends previous observations that psychopathy engenders deficits in fear learning, physiological responses to threats, and the recognition of fear in others. © 2010 The Authors. Journal of Child Psychology and Psychiatry © 2010 Association for Child and Adolescent Mental Health.

  1. Responsiveness of observational and self-report methods for assessing disability in mobility in patients with osteoarthritis.

    NARCIS (Netherlands)

    Steultjens, M.P.M.; Roorda, L.D.; Dekker, J.; Bijlsma, J.W.J.

    2001-01-01

    Objective: To establish the responsiveness of observational and self-report methods for the assessment of disability in mobility in patients with osteoarthritis (OA). Methods: Data from 186 patients with hip OA of knee OA were used. Data from 1 observational method and 4 self-report methods for the

  2. 34 CFR 611.46 - What are a scholarship recipient's reporting responsibilities upon graduation from the teacher...

    Science.gov (United States)

    2010-07-01

    ..., and other identifying information about the recipient; (ii) That he or she is teaching in a high-need... 34 Education 3 2010-07-01 2010-07-01 false What are a scholarship recipient's reporting... scholarship recipient's reporting responsibilities upon graduation from the teacher preparation program? (a...

  3. Non-Linear Dose Response Relationships in Biology, Toxicology, and Medicine (June 8-10, 2004). Final Report

    International Nuclear Information System (INIS)

    Calabrese, Edward J.

    2004-01-01

    The conference attracts approximately 500 scientists researching in the area of non-linear low dose effects. These scientists represent a wide range of biological/medical fields and technical disciplines. Observations that biphasic dose responses are frequently reported in each of these areas but that the recognition of similar dose response relationships across disciplines is very rarely appreciated and exploited. By bringing scientist of such diverse backgrounds together who are working on the common area of non-linear dose response relationships this will enhance our understanding of the occurrence, origin, mechanism, significance and practical applications of such dose response relationships

  4. Comment response document for the Secretary of Energy's ''Report to Congress on Reassessment of the Civilian Radioactive Waste Management Program''

    International Nuclear Information System (INIS)

    1990-11-01

    On November 29, 1989, the Secretary of Energy published his ''Report to Congress on the Reassessment of the Civilian Radioactive Waste Management Program'' (Report), and sent copies to numerous interested parties for their review and comment. This document summarizes comments received on the Report and presents the DOE's current responses to those comments as a basis for further discussions. Included as appendixes are a list of commenters, a crosswalk showing where each comment is addressed, the comment letters themselves with specific comments delineated, and the DOE's response to those letters. Twenty-five individuals or organizations submitted comments on the Report. The DOE identified 130 individual comments and classified them into the following seven categories: Management, Institutional, Regulatory, Transportation, Monitored Retrievable Storage, Scheduling, and Yucca Mountain. For the responses, comments were than grouped into more specific topics under each of the major headings. The DOE attempted to respond to all comments

  5. Is patient responsibility for managing musculoskeletal disorders related to self-reported better outcome of physiotherapy treatment?

    Science.gov (United States)

    Larsson, Maria E H; Kreuter, Margareta; Nordholm, Lena

    2010-07-01

    Musculoskeletal disorders are prevalent and a major burden on individuals and society. Information on relationships of patient involvement and responsibility to outcome is limited. This study aimed to explore relationships between self-reported outcome of physiotherapy treatment and attitudes toward responsibility for musculoskeletal disorders. A cross-sectional postal survey design was used. Patients (n=615) from an outpatient physiotherapy clinic, who had finished their physiotherapy treatment within the last 6 months were sent a questionnaire that included the Attitudes regarding Responsibility for Musculoskeletal disorders instrument (ARM), self-reported outcome of treatment and sociodemographic data. A total of 279 (45%) completed forms were returned. Multiple logistic regression analysis was used. The patients' scores on the four dimensions of ARM ("responsibility self active," "responsibility out of my hands," "responsibility employer," and "responsibility medical professionals"), controlled for age, sex, education, and physical activity as well as for number of treatments, main treatment, and physiotherapist, were associated with the patients' self-reported treatment outcome. Patients who attributed responsibility more to themselves were more likely (OR 2.37 and over) to report considerable improvement as the outcome of physiotherapy treatment. Because this study was conducted at only one physiotherapy outpatient clinic and had a cross-sectional design, the results should be replicated in other settings. Because patients' attitudes regarding responsibility for musculoskeletal disorders can possibly affect the outcome of physiotherapy treatment, it might be useful to decide whether to systematically try to influence the person's attitude toward responsibility for the management of the disorder or to match treatment to attitude.

  6. Report to Congress in response to Public Law 99-240: 1990 Annual report on low-level radioactive waste management progress

    International Nuclear Information System (INIS)

    1991-09-01

    This report summarizes the progress during 1990 of states and compact regions in establishing new low-level radioactive waste disposal facilities. It also provides summary information on the volume of low-level radioactive waste received for disposal in 1990 by commercially operated low-level radioactive waste disposal facilities. This report is in response to section 7 (b) of the Low-Level Radioactive Waste Policy Act, as amended by Public Law 99-240

  7. 1987 annual report on low-level radioactive waste management progress: Report to Congress in response to Public Law 99-240

    International Nuclear Information System (INIS)

    1988-08-01

    In response to Section 7(b) of the Low-Level Radioactive Waste Policy Amendments Act of 1985 (Public Law 99-240), this report summarizes the progress of states and low-level radioactive waste compacts in 1987 in establishing new low-level waste disposal facilities. It also reports the volume of low-level waste received for disposal in 1987 by commercially operated low-level waste disposal facilities

  8. Visions for a sustainable world: A conference on science, technology and social responsibility. Conference report

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    This report summarizes the organization, activities, and outcomes of Student Pugwash USA`s 1992 International Conference, Visions for a Sustainable World: A Conference on Science, Technology and Social Responsibility. The conference was held June 14--20, 1992 at Emory University, and brought together 94 students and over 65 experts from industry, academe, and government. The conference addressed issues ranging from global environmental cooperation to the social impacts of the Human Genome Project to minority concerns in the sciences. It provided a valuable forum for talented students and professionals to engage in critical dialogue on many interdisciplinary issues at the juncture of science, technology and society. The conference challenged students -- the world`s future scientists, engineers, and political leaders -- to think broadly about global problems and to devise policy options that are viable and innovative. The success of the conference in stimulating interest, understanding, and enthusiasm about interdisciplinary global issues is clearly evident from both the participants` feedback and their continued involvement in Student Pugwash USA programs. Six working groups met each morning. The working group themes included: environmental challenges for developing countries; energy options: their social and environmental impact; health care in developing countries; changing dynamics of peace and global security; educating for the socially responsible use of technology; ethics and the use of genetic information. The conference was specifically designed to include mechanisms for ensuring its long-term impact. Participants were encouraged to focus on their individual role in helping resolve global issues. This was achieved through each participant`s development of a Personal Plan of Action, a plan which mapped out activities the student could undertake after the conference to continue the dialogue and work towards the resolution of global and local problems.

  9. 2015 California Demand Response Potential Study - Charting California’s Demand Response Future. Interim Report on Phase 1 Results

    Energy Technology Data Exchange (ETDEWEB)

    Alstone, Peter; Potter, Jennifer; Piette, Mary Ann; Schwartz, Peter; Berger, Michael A.; Dunn, Laurel N.; Smith, Sarah J.; Sohn, Michael D.; Aghajanzadeh, Arian; Stensson, Sofia; Szinai, Julia

    2016-04-01

    Demand response (DR) is an important resource for keeping the electricity grid stable and efficient; deferring upgrades to generation, transmission, and distribution systems; and providing other customer economic benefits. This study estimates the potential size and cost of the available DR resource for California’s three investor-owned utilities (IOUs), as the California Public Utilities Commission (CPUC) evaluates how to enhance the role of DR in meeting California’s resource planning needs and operational requirements. As the state forges a clean energy future, the contributions of wind and solar electricity from centralized and distributed generation will fundamentally change the power grid’s operational dynamics. This transition requires careful planning to ensure sufficient capacity is available with the right characteristics – flexibility and fast response – to meet reliability needs. Illustrated is a snapshot of how net load (the difference between demand and intermittent renewables) is expected to shift. Increasing contributions from renewable generation introduces steeper ramps and a shift, into the evening, of the hours that drive capacity needs. These hours of peak capacity need are indicated by the black dots on the plots. Ultimately this study quantifies the ability and the cost of using DR resources to help meet the capacity need at these forecasted critical hours in the state.

  10. Long-Lasting Response to Trabectedin in a Patient with Metastatic Uterine Leiomyosarcoma: A Case Report

    Directory of Open Access Journals (Sweden)

    Viktoria-Anna Nteli

    2018-02-01

    Full Text Available Background: Uterine leiomyosarcoma (uLMS is a rare tumor that accounts for 1% of all uterine malignancies. In spite of adequate surgical resection of uLMS, even in the early stage, patients remain at high risk for local and distant recurrence. Therefore, the treatment of advanced uLMS represents a considerable challenge. Methods: We report the case of a 47-year-old woman who presented with uLMS with abnormal vaginal bleeding. Results: The patient underwent a total hysterectomy and bilateral adnexectomy, which was followed by 1 year progression-free survival without adjuvant therapy. Thereafter, new lung metastases and local progression at the vaginal stump were observed. Chemotherapy with ifosfamide and doxorubicin was administered. However, after 4 cycles, a CT scan revealed disease progression in the lung metastases. Subsequently, the patient was treated with trabectedin at a dose of 1.5 mg/m2 for 6 cycles resulting in complete remission of the lung metastases as well as partial remission of the mass in the vaginal stump after 9 cycles of trabectedin. The patient is currently on maintenance therapy with trabectedin and has no recurrence. Conclusion: Trabectedin seems to be an efficient option for patients with uLMS as demonstrated by a long-lasting response in a pretreated patient with an acceptable safety profile with no signs of cumulative toxicity.

  11. Power Transfer Potential to the Southeast in Response to a Renewable Portfolio Standard: Interim Report 1

    Energy Technology Data Exchange (ETDEWEB)

    Hadley, Stanton W [ORNL; Key, Thomas S [Electric Power Research Institute (EPRI)

    2009-03-01

    The power transfer potential for bringing renewable energy into the Southeast in response to a renewable portfolio standard (RPS) will depend not only on available transmission capacity but also on electricity supply and demand factors. This interim report examines how the commonly used EIA NEMS and EPRI NESSIE energy equilibrium models are considering such power transfers. Using regional estimates of capacity expansion and demand, a base case for 2008, 2020 and 2030 are compared relative to generation mix, renewable deployments, planned power transfers, and meeting RPS goals. The needed amounts of regional renewable energy to comply with possible RPS levels are compared to inter-regional transmission capacities to establish a baseline available for import into the Southeast and other regions. Gaps in the renewable generation available to meet RPS requirements are calculated. The initial finding is that the physical capability for transferring renewable energy into the SE is only about 10% of what would be required to meet a 20% RPS. Issues that need to be addressed in future tasks with respect to modeling are the current limitations for expanding renewable capacity and generation in one region to meet the demand in another and the details on transmission corridors required to deliver the power.

  12. Sexual Harassment in Academic Medicine: Persistence, Non-Reporting, and Institutional Response.

    Science.gov (United States)

    Wear, Delese; Aultman, Julie

    2005-12-01

    Sexual harassment occurs with regularity during medical training, and it remains largely unreported. This study is one institution's attempt to understand how third and fourth-year medical students perceive and experience sexual harassment, what they believe about reporting sexual harassment, and how they believe it might be eradicated from the educational environment. We used a qualitative research method for our investigation, which would generate more specific language to use in a larger empirical study involving larger numbers of our students. We conducted five focus groups with 24 students, which yielded five categories of response obtained through a close, line-byline reading of transcribed audiotapes. In addition, we offer four recommendations to medical education researchers, deans of medical schools, and medical school accrediting bodies that may reduce the incidence of sexual harassment of medical students. While we do not make the case that the observations, explanations, and recommendations of these 24 students reflect the opinions of all medical students here or elsewhere, we do propose that they are a snapshot of one medical school's gender climate and offer a valuable foundation for further inquiry.

  13. Management response plan for the Chemical Safety Vulnerability Working Group report. Volume 1

    International Nuclear Information System (INIS)

    1994-09-01

    The Chemical Safety Vulnerability (CSV) Working Group was established to identify adverse conditions involving hazardous chemicals at DOE facilities that might result in fires or explosions, release of hazardous chemicals to the environment, or exposure of workers or the public to chemicals. A CSV Review was conducted in 146 facilities at 29 sites. Eight generic vulnerabilities were documented related to: abandoned chemicals and chemical residuals; past chemical spills and ground releases; characterization of legacy chemicals and wastes; disposition of legacy chemicals; storage facilities and conditions; condition of facilities and support systems; unanalyzed and unaddressed hazards; and inventory control and tracking. Weaknesses in five programmatic areas were also identified related to: management commitment and planning; chemical safety management programs; aging facilities that continue to operate; nonoperating facilities awaiting deactivation; and resource allocations. Volume 1 contains a discussion of the chemical safety improvements planned or already underway at DOE sites to correct facility or site-specific vulnerabilities. The main part of the report is a discussion of each of the programmatic deficiencies; a description of the tasks to be accomplished; the specific actions to be taken; and the organizational responsibilities for implementation

  14. FINAL PROJECT REPORT - EVALUATION AND TESTING OF HTGR REACTOR BUILDING RESPONSE TO DEPRESSURIZATION ACCIDENTS

    Energy Technology Data Exchange (ETDEWEB)

    ALLIANCE LIMITED, NGNP INDUSTRY

    2017-07-25

    This report provides a description of the project, summarizes each phase of the project, and ends with project conclusions. In addition, the report contains a descriptive index of the technical reports generated during the course of the project.

  15. Physiological Response and Habituation of Endangered Species to Military Training Activities: SERDP 2006 Annual Report

    National Research Council Canada - National Science Library

    Hayden, Timothy J; Bisson, Isabelle; Wikelski, Martin; Butler, Luke; Romero, L. M

    2008-01-01

    .... During the 2006 breeding season on Fort Hood, Texas, evaluations of two major physiological response systems determined response in passerine species to disturbances characteristic of military training activities: a hormonal (adrenocortical...

  16. Parental Catastrophizing Partially Mediates the Association between Parent-Reported Child Pain Behavior and Parental Protective Responses

    OpenAIRE

    Langer, Shelby L.; Romano, Joan M.; Mancl, Lloyd; Levy, Rona L.

    2014-01-01

    This study sought to model and test the role of parental catastrophizing in relationship to parent-reported child pain behavior and parental protective (solicitous) responses to child pain in a sample of children with Inflammatory Bowel Disease and their parents (n = 184 dyads). Parents completed measures designed to assess cognitions about and responses to their child's abdominal pain. They also rated their child's pain behavior. Mediation analyses were performed using regression-based techn...

  17. Middle components of the auditory evoked response in bilateral temporal lobe lesions. Report on a patient with auditory agnosia

    DEFF Research Database (Denmark)

    Parving, A; Salomon, G; Elberling, Claus

    1980-01-01

    An investigation of the middle components of the auditory evoked response (10--50 msec post-stimulus) in a patient with auditory agnosia is reported. Bilateral temporal lobe infarctions were proved by means of brain scintigraphy, CAT scanning, and regional cerebral blood flow measurements...... that the middle components cannot be generated exclusively, if at all, in the primary auditory cortex, located in the temporal lobe. Furthermore, the responses are found to be of neurogenic origin according to the methodological procedure applied....

  18. Telephone Flat Geothermal Development Project Environmental Impact Statement Environmental Impact Report. Final: Comments and Responses to Comments

    Energy Technology Data Exchange (ETDEWEB)

    None

    1999-02-01

    This document is the Comments and Responses to Comments volume of the Final Environmental Impact Statement and Environmental Impact Report prepared for the proposed Telephone Flat Geothermal Development Project (Final EIS/EIR). This volume of the Final EIS/EIR provides copies of the written comments received on the Draft EIS/EIR and the leady agency responses to those comments in conformance with the requirements of the National Environmental Policy Act (NEPA) and the California Environmental Quality Act (CEQA).

  19. Brief Report: Parent Verbal Responsiveness and Language Development in Toddlers on the Autism Spectrum

    Science.gov (United States)

    Haebig, Eileen; McDuffie, Andrea; Ellis Weismer, Susan

    2013-01-01

    This study examined the longitudinal associations between parent verbal responsiveness and language 3 years later in 34 toddlers with a diagnosis of an autism spectrum disorder. Parent-child play samples were coded for child engagement and communication acts and for parent verbal responsiveness. Measures of responsive verbal behaviors were used to…

  20. Preliminary report on operational guidelines developed for use in emergency preparedness and response to a radiological dispersal device incident.

    Energy Technology Data Exchange (ETDEWEB)

    Yu, C.; Cheng, J.-J.; Kamboj, S.; Domotor, S.; Wallo, A.; Environmental Science Division; DOE

    2006-12-15

    This report presents preliminary operational guidelines and supporting work products developed through the interagency Operational Guidelines Task Group (OGT). The report consolidates preliminary operational guidelines, all ancillary work products, and a companion software tool that facilitates their implementation into one reference source document. The report is intended for interim use and comment and provides the foundation for fostering future reviews of the operational guidelines and their implementation within emergency preparedness and response initiatives in the event of a radiological dispersal device (RDD) incident. The report principally focuses on the technical derivation and presentation of the operational guidelines. End-user guidance providing more details on how to apply these operational guidelines within planning and response settings is being considered and developed elsewhere. The preliminary operational guidelines are categorized into seven groups on the basis of their intended application within early, intermediate, and long-term recovery phases of emergency response. We anticipate that these operational guidelines will be updated and refined by interested government agencies in response to comments and lessons learned from their review, consideration, and trial application. This review, comment, and trial application process will facilitate the selection of a final set of operational guidelines that may be more or less inclusive of the preliminary operational guidelines presented in this report. These and updated versions of the operational guidelines will be made available through the OGT public Web site (http://ogcms.energy.gov) as they become finalized for public distribution and comment.

  1. 2025 California Demand Response Potential Study - Charting California’s Demand Response Future. Final Report on Phase 2 Results

    Energy Technology Data Exchange (ETDEWEB)

    Alstone, Peter [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Potter, Jennifer [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Piette, Mary Ann [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Schwartz, Peter [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Berger, Michael A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Dunn, Laurel N. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Smith, Sarah J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sohn, Michael D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Aghajanzadeh, Aruab [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Stensson, Sofia [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Szinai, Julie [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Walter, Travis [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); McKenzie, Lucy [Energy and Environmental Economics, Inc. (E3), San Francisco, CA (United States); Lavin, Luke [Energy and Environmental Economics, Inc. (E3), San Francisco, CA (United States); Schneiderman, Brendan [Energy and Environmental Economics, Inc. (E3), San Francisco, CA (United States); Mileva, Ana [Energy and Environmental Economics, Inc. (E3), San Francisco, CA (United States); Cutter, Eric [Energy and Environmental Economics, Inc. (E3), San Francisco, CA (United States); Olson, Arne [Energy and Environmental Economics, Inc. (E3), San Francisco, CA (United States); Bode, Josh [Nexant, Inc., Nashville, TN (United States); Ciccone, Adriana [Nexant, Inc., Nashville, TN (United States); Jain, Ankit [Nexant, Inc., Nashville, TN (United States)

    2017-03-01

    California’s legislative and regulatory goals for renewable energy are changing the power grid’s dynamics. Increased variable generation resource penetration connected to the bulk power system, as well as, distributed energy resources (DERs) connected to the distribution system affect the grid’s reliable operation over many different time scales (e.g., days to hours to minutes to seconds). As the state continues this transition, it will require careful planning to ensure resources with the right characteristics are available to meet changing grid management needs. Demand response (DR) has the potential to provide important resources for keeping the electricity grid stable and efficient, to defer upgrades to generation, transmission and distribution systems, and to deliver customer economic benefits. This study estimates the potential size and cost of future DR resources for California’s three investor-owned utilities (IOUs): Pacific Gas and Electric Company (PG&E), Southern California Edison Company (SCE), and San Diego Gas & Electric Company (SDG&E). Our goal is to provide data-driven insights as the California Public Utilities Commission (CPUC) evaluates how to enhance DR’s role in meeting California’s resource planning needs and operational requirements. We address two fundamental questions: 1. What cost-competitive DR service types will meet California’s future grid needs as it moves towards clean energy and advanced infrastructure? 2. What is the size and cost of the expected resource base for the DR service types?

  2. Balancing Work Responsibilities and Family Needs: The Federal Civil Service Response. A Report Concerning Significant Actions of the U.S. Office of Personnel Management. A Report to the President and the Congress of the United States.

    Science.gov (United States)

    Merit Systems Protection Board, Washington, DC.

    This report examines actions of the U.S. Office of Personnel Management in providing leadership to several of the government's human resource management programs in the work and family benefits area. It reviews employee benefit programs that help civilian federal workers balance their work responsibilities and personal needs. Programs reviewed are…

  3. Making the Supply Chain visible Reporting of corporate social responsibility in the supply chain; An investigation into UK clothing retailers

    OpenAIRE

    Warren, Hayely Joanne

    2010-01-01

    Purpose – This paper offers a preliminary exploration of the corporate social responsibility (CSR) issues being addressed by UK owned clothing retailers. The study focuses on what retailers disclose and report with regards to the social activities in their supply chain, and discusses whether the information provides a ‘visible’ account of the activities in the social supply chain. Design/methodology/approach – The paper draws its empirical information from the CSR reports and information ...

  4. Structures and shear response of lipid monolayers. Progress report, August 1, 1993--January 31, 1996

    International Nuclear Information System (INIS)

    Dutta, P.; Ketterson, J.B.

    1995-08-01

    Of the many systems now classified as open-quotes soft condensed matterclose quotes, lipids are some of the best known and most studied. Lipids occur most commonly in membranes, but the artificially created lipid systems known as Langmuir films (on water) and Langmuir-Blodgett films (on solid substrates) are in some ways better-defined and more easily controlled systems with which to address many of the same questions. Studies of these systems have a long and distinguished history, but in the past decade there has been an explosion of activity in this area, driven by the availability of a or more powerful experimental probes but also in part by the hope of producing new structured molecular materials and devices. Today the focus of device-oriented research is shifting to self-assembled (chemisorbed) films, because it is recognized that these films are somewhat more stable under application conditions. This trend has resulted in a generally more appropriate view of Langmuir and Langmuir Blodgett films as model systems with which to study the properties of organized molecular assemblies. These films are part of a larger class that includes membranes, lamellar paraffins and liquid crystals as well as self-assembled films, but with certain experimental and conceptual advantages (such as the ease with which the density may be varied, and the tethering to a flat plane). This report describes the continued studies of the phase diagrams of Langmuir monolayers, and efforts to understand the variables that affect the structures formed. It also describes studies of the structure of a transferred monolayer, and how this evolves as further layers are added. Finally, the authors describe their studies of the mechanical response of Langmuir-Blodgett films using a small-strain torsion balance at the center of a circular trough

  5. Brief Report: Parent Verbal Responsiveness and Language Development in Toddlers on the Autism Spectrum

    OpenAIRE

    Haebig, Eileen; McDuffie, Andrea; Weismer, Susan Ellis

    2013-01-01

    This study examined the longitudinal associations between parent verbal responsiveness and language three years later in 34 toddlers with a diagnosis of an autism spectrum disorder (ASD). Parent-child play samples were coded for child engagement and communication acts and for parent verbal responsiveness. Measures of responsive verbal behaviors were used to predict language gain scores three years later. Parent directives for language that followed into the child’s focus of attention were pre...

  6. Interpretation of response categories in patient-reported rating scales: a controlled study among people with Parkinson's disease

    Directory of Open Access Journals (Sweden)

    Knutsson Ida

    2010-06-01

    Full Text Available Abstract Background Unambiguous interpretation of ordered rating scale response categories requires distinct meanings of category labels. Also, summation of item responses into total scores assumes equal intervals between categories. While studies have identified problems with rating scale response category functioning there is a paucity of empirical studies regarding how respondents interpret response categories. We investigated the interpretation of commonly used rating scale response categories and attempted to identify distinct and roughly equally spaced response categories for patient-reported rating scales in Parkinson's disease (PD and age-matched control subjects. Methods Twenty-one rating scale response categories representing frequency, intensity and level of agreement were presented in random order to 51 people with PD (36 men; mean age, 66 years and 36 age-matched controls (14 men; mean age, 66. Respondents indicated their interpretation of each category on 100-mm visual analog scales (VAS anchored by Never - Always, Not at all - Extremely, and Totally disagree - Completely agree. VAS values were compared between groups, and response categories with mean values and non-overlapping 95% CIs corresponding to equally spaced locations on the VAS line were sought to identify the best options for three-, four-, five-, and six-category scales. Results VAS values did not differ between the PD and control samples (P = 0.286 or according to educational level (P = 0.220, age (P = 0.220, self-reported physical functioning (P = 0.501 and mental health (P = 0.238, or (for the PD sample PD duration (P = 0.213 or presence of dyskinesias (P = 0.212. Attempts to identify roughly equally spaced response categories for three-, four-, five-, and six-category scales were unsuccessful, as the 95% CIs of one or several of the identified response categories failed to include the criterion values for equal distances. Conclusions This study offers an evidence

  7. Remarkable response to photodynamic therapy in residual T4N0M0 nasopharyngeal carcinoma: a case report

    NARCIS (Netherlands)

    Indrasari, S. R.; Timmermans, A. J.; Wildeman, M. A.; Karakullukcu, M. B.; Herdini, C.; Hariwiyanto, B.; Tan, I. B.

    2012-01-01

    Local treatment of residual or recurrent nasopharyngeal carcinoma (NPC) is a challenge. Photodynamic therapy (PDT) is an established treatment modality for incurable head and neck carcinoma. Several studies reported induction of an immune response after PDT. We present a patient with residual T4N0M0

  8. Responsiveness to Self-Report Questions about Loneliness: A Comparison of Mainstream and Intellectual Disability-Specific Instruments

    Science.gov (United States)

    Stancliffe, R. J.; Wilson, N. J.; Bigby, C.; Balandin, S.; Craig, D.

    2014-01-01

    Background: We compared responsiveness to two self-report assessments of loneliness: the "UCLA Loneliness Scale" (UCLALS) designed for the general community, and the "Modified Worker Loneliness Questionnaire" (MWLQ) designed for people with intellectual disability (ID). Methods: Participants were 56 older adults with…

  9. 18 CFR 1309.12 - What are a recipient's responsibilities on compliance reports and access to information?

    Science.gov (United States)

    2010-04-01

    ... to enable the primary recipient to carry out its obligations under this part. (b) Access to sources... books, records, accounts and other sources of information, and its facilities as may be pertinent to... responsibilities on compliance reports and access to information? 1309.12 Section 1309.12 Conservation of Power and...

  10. 34 CFR 611.48 - What are a scholarship recipient's reporting responsibilities upon failure to graduate or...

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What are a scholarship recipient's reporting responsibilities upon failure to graduate or withdrawal of scholarship support? 611.48 Section 611.48 Education..., DEPARTMENT OF EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Scholarships § 611.48 What are a...

  11. Associations among Children's Social Goals, Responses to Peer Conflict, and Teacher-Reported Behavioral and Academic Adjustment at School

    Science.gov (United States)

    Ojanen, Tiina; Smith-Schrandt, Heather L.; Gesten, Ellis

    2013-01-01

    This study examined associations among children's agentic (social influence, status, power) and communal (relationship, affiliation) goals for peer interaction, cognitive and affective responses to hypothetical peer conflict, and teacher-reported achievement and behavior at school ("N" = 367; "M" age = 9.9 years). Agentic goals…

  12. Response to state comments on the revised draft Southeastern Regional Characterization Reports for the Crystalline Repository Project

    International Nuclear Information System (INIS)

    1985-08-01

    The purpose of this document is to respond to the comments received from the states of the Southeastern Region on the revised draft Southeastern Regional Characterization Reports (RCRs). The responses in this document indicate the manner in which the suggestions or comments received have been considered in modifying the revised draft Southeastern RCRs. Both general comments related to the overall Crystalline Repository Project (CRP) and comments on specific sections of the RCRs are addressed. This document responds to Southeastern State comments on both the revised draft Southeastern Regional Geologic Characterization Report (RGCR) and the revised draft Southeastern Regional Environmental Characterization Report (RECR)

  13. Thiamine responsive megaloblastic anemia syndrome associated with patent ductus arteriosus: First case report from Kashmir Valley of the Indian subcontinent

    Directory of Open Access Journals (Sweden)

    Mohd Ashraf Ganie

    2012-01-01

    Full Text Available Thiamine responsive megaloblastic anemia syndrome, an autosomal recessive inherited disorder characterized by a triad of anemia, diabetes mellitus and sensorineural deafness is caused by a deficiency of a thiamine transporter protein. The disorder is rare and has not been reported from our community which has high background of consanguinity. We report a six years old girl who presented with diabetes mellitus which remitted after thiamine replacement. The girl in addition had sensorineural deafness, reinopathy, atrial septal defect and megaloblastic anemia which responded to high doses of thymine. This is the first case reported from Kashmir valley and third from India. The presentation and management in such cases is discussed.

  14. Response to state comments on the revised draft North Central Regional characterization reports for the Crystalline Repository Project

    International Nuclear Information System (INIS)

    1985-08-01

    The purpose of this document is to respond to the comments received from the states of the North Central Region on the revised draft North Central Regional Characterization Reports (RCRs). The responses in this document indicate the manner in which the suggestions or comments received have been considered in modifying the revised draft North Central RCRs. Both general comments related to the overall Crystalline Repository Project (CRP) and comments on specific sections of the RCRs are addressed. This document responds to North Central State comments on both the revised draft North Central Regional Geologic Characterization Report (RGCR) and the revised draft North Central Regional Environmental Characterization Report (RECR)

  15. Response to state comments on the revised draft northeastern regional characterization reports for the Crystalline Repository Project

    International Nuclear Information System (INIS)

    1985-08-01

    The purpose of this document is to respond to the comments received from the States of the Northeastern Region on the revised draft Northeastern Regional Characterization Reports (RCRs). The responses in this document indicate the manner in which the suggestions or comments received have been considered in modifying the revised draft Northeastern RCRs. Both general comments related to the overall Crystalline Repository Project (CRP) and comments on specific sections of the RCRs are addressed. This document responds to Northeastern State comments on both the revised draft Northeastern Regional Geologic Characterization Report (RGCR) and the revised draft Northeastern Regional Environmental Characterization Report (RECR)

  16. Self-reported responsiveness to direct-to-consumer drug advertising and medication use: results of a national survey

    Directory of Open Access Journals (Sweden)

    Somes Grant W

    2011-09-01

    Full Text Available Abstract Background Direct-to-consumer (DTC marketing of pharmaceuticals is controversial, yet effective. Little is known relating patterns of medication use to patient responsiveness to DTC. Methods We conducted a secondary analysis of data collected in national telephone survey on knowledge of and attitudes toward DTC advertisements. The survey of 1081 U.S. adults (response rate = 65% was conducted by the Food and Drug Administration (FDA. Responsiveness to DTC was defined as an affirmative response to the item: "Has an advertisement for a prescription drug ever caused you to ask a doctor about a medical condition or illness of your own that you had not talked to a doctor about before?" Patients reported number of prescription and over-the-counter (OTC medicines taken as well as demographic and personal health information. Results Of 771 respondents who met study criteria, 195 (25% were responsive to DTC. Only 7% respondents taking no prescription were responsive, whereas 45% of respondents taking 5 or more prescription medications were responsive. This trend remained significant (p trend .0009 even when controlling for age, gender, race, educational attainment, income, self-reported health status, and whether respondents "liked" DTC advertising. There was no relationship between the number of OTC medications taken and the propensity to discuss health-related problems in response to DTC advertisements (p = .4. Conclusion There is a strong cross-sectional relationship between the number of prescription, but not OTC, drugs used and responsiveness to DTC advertising. Although this relationship could be explained by physician compliance with patient requests for medications, it is also plausible that DTC advertisements have a particular appeal to patients prone to taking multiple medications. Outpatients motivated to discuss medical conditions based on their exposure to DTC advertising may require a careful medication history to evaluate for

  17. Evaluating the Emotion Ontology through use in the self-reporting of emotional responses at an academic conference.

    Science.gov (United States)

    Hastings, Janna; Brass, Andy; Caine, Colin; Jay, Caroline; Stevens, Robert

    2014-01-01

    We evaluate the application of the Emotion Ontology (EM) to the task of self-reporting of emotional experience in the context of audience response to academic presentations at the International Conference on Biomedical Ontology (ICBO). Ontology evaluation is regarded as a difficult task. Types of ontology evaluation range from gauging adherence to some philosophical principles, following some engineering method, to assessing fitness for purpose. The Emotion Ontology (EM) represents emotions and all related affective phenomena, and should enable self-reporting or articulation of emotional states and responses; how do we know if this is the case? Here we use the EM 'in the wild' in order to evaluate the EM's ability to capture people's self-reported emotional responses to a situation through use of the vocabulary provided by the EM. To achieve this evaluation we developed a tool, EmOntoTag, in which audience members were able to capture their self-reported emotional responses to scientific presentations using the vocabulary offered by the EM. We furthermore asked participants using the tool to rate the appropriateness of an EM vocabulary term for capturing their self-assessed emotional response. Participants were also able to suggest improvements to the EM using a free-text feedback facility. Here, we present the data captured and analyse the EM's fitness for purpose in reporting emotional responses to conference talks. Based on our analysis of this data set, our primary finding is that the audience are able to articulate their emotional response to a talk via the EM, and reporting via the EM ontology is able to draw distinctions between the audience's response to a speaker and between the speakers (or talks) themselves. Thus we can conclude that the vocabulary provided at the leaves of the EM are fit for purpose in this setting. We additionally obtained interesting observations from the experiment as a whole, such as that the majority of emotions captured had

  18. Opportunities for Energy Efficiency and Open Automated Demand Response in Wastewater Treatment Facilities in California -- Phase I Report

    Energy Technology Data Exchange (ETDEWEB)

    Lekov, Alex; Thompson, Lisa; McKane, Aimee; Song, Katherine; Piette, Mary Ann

    2009-04-01

    This report summarizes the Lawrence Berkeley National Laboratory?s research to date in characterizing energy efficiency and automated demand response opportunities for wastewater treatment facilities in California. The report describes the characteristics of wastewater treatment facilities, the nature of the wastewater stream, energy use and demand, as well as details of the wastewater treatment process. It also discusses control systems and energy efficiency and automated demand response opportunities. In addition, several energy efficiency and load management case studies are provided for wastewater treatment facilities.This study shows that wastewater treatment facilities can be excellent candidates for open automated demand response and that facilities which have implemented energy efficiency measures and have centralized control systems are well-suited to shift or shed electrical loads in response to financial incentives, utility bill savings, and/or opportunities to enhance reliability of service. Control technologies installed for energy efficiency and load management purposes can often be adapted for automated demand response at little additional cost. These improved controls may prepare facilities to be more receptive to open automated demand response due to both increased confidence in the opportunities for controlling energy cost/use and access to the real-time data.

  19. Stochastic Approximation Methods for Latent Regression Item Response Models. Research Report. ETS RR-09-09

    Science.gov (United States)

    von Davier, Matthias; Sinharay, Sandip

    2009-01-01

    This paper presents an application of a stochastic approximation EM-algorithm using a Metropolis-Hastings sampler to estimate the parameters of an item response latent regression model. Latent regression models are extensions of item response theory (IRT) to a 2-level latent variable model in which covariates serve as predictors of the…

  20. IRTPRO 2.1 for Windows (Item Response Theory for Patient-Reported Outcomes)

    Science.gov (United States)

    Paek, Insu; Han, Kyung T.

    2013-01-01

    This article reviews a new item response theory (IRT) model estimation program, IRTPRO 2.1, for Windows that is capable of unidimensional and multidimensional IRT model estimation for existing and user-specified constrained IRT models for dichotomously and polytomously scored item response data. (Contains 1 figure and 2 notes.)

  1. Brief Report: Empathic Responsiveness of High Functioning Children with Autism to Expressed and Anticipated Distress

    Science.gov (United States)

    Newbigin, Amanda; Uljarevic, Mirko; Vivanti, Giacomo; Dissanayake, Cheryl

    2016-01-01

    The majority of studies that have investigated empathic responsiveness of individuals with Autism spectrum disorder (ASD) have used heterogeneous groups in terms of age, cognitive level and gender which significantly impact the results. Our aim in this study was to explore responsiveness of a more homogenous sample of 21 children with ASD and 17…

  2. Chemotherapy induced pathologic complete response in malignant pleural mesothelioma: a review and case report

    DEFF Research Database (Denmark)

    Bech, Cecilia; Sørensen, Jens Benn

    2010-01-01

    Malignant pleural mesothelioma is a rare aggressive disease with a poor prognosis and usually modest responses to chemotherapy. Complete responses (CRs) to chemotherapy are rare. Evaluation is usually based on radiology, and CR is therefore clinical CR (cCR) and whether this indicates absence...

  3. Conceptual design report, Hazardous Materials Management and Emergency Response (HAMMER) Training Center

    International Nuclear Information System (INIS)

    Kelly, K.E.

    1994-01-01

    For the next 30 years, the main activities at the US Department of Energy (DOE) Hanford Site will involve the management, handling, and cleanup of toxic substances. If the DOE is to meet its high standards of safety, the thousands of workers involved in these activities will need systematic training appropriate to their tasks and the risks associated with these tasks. Furthermore, emergency response for DOE shipments is the primary responsibility of state, tribal, and local governments. A collaborative training initiative with the DOE will strengthen emergency response at the Hanford Site and within the regional communities. Local and international labor has joined the Hazardous Materials Management and Emergency Response (HAMMER) partnership, and will share in the HAMMER Training Center core programs and facilities using their own specialized trainers and training programs. The HAMMER Training Center will provide a centralized regional site dedicated to the training of hazardous material, emergency response, and fire fighting personnel

  4. Conceptual design report, Hazardous Materials Management and Emergency Response (HAMMER) Training Center

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, K.E. [Westinghouse Hanford Co., Richland, WA (United States)

    1994-11-09

    For the next 30 years, the main activities at the US Department of Energy (DOE) Hanford Site will involve the management, handling, and cleanup of toxic substances. If the DOE is to meet its high standards of safety, the thousands of workers involved in these activities will need systematic training appropriate to their tasks and the risks associated with these tasks. Furthermore, emergency response for DOE shipments is the primary responsibility of state, tribal, and local governments. A collaborative training initiative with the DOE will strengthen emergency response at the Hanford Site and within the regional communities. Local and international labor has joined the Hazardous Materials Management and Emergency Response (HAMMER) partnership, and will share in the HAMMER Training Center core programs and facilities using their own specialized trainers and training programs. The HAMMER Training Center will provide a centralized regional site dedicated to the training of hazardous material, emergency response, and fire fighting personnel.

  5. Intravascular pulmonary lymphoma with good response to treatment. A case report

    Directory of Open Access Journals (Sweden)

    M. Felizardo

    2008-11-01

    Full Text Available Intravascular lymphoma is a very rare form of large B cell non-Hodgkin's lymphoma, characterised by the presence of lymphoma cells in the lumina of small vessels only, particulary in the capillaries. We report a 54 year-old female non-smoker, admitted to hospital for further examination of a four month long clinical condition involving high fever, night sweats, unqualified weight loss and progressive dyspnea. Patient's temperature was 38.5 °C, pulse 100/min and respiratory 22 cycles/min.Patient's haemoglobin was 9.4 g/dL, she had leukocytosis, elevated LDH and arterial blood gas analysis with moderate hypoxaemia (FiO2 1l/m: PaO2-63.6 mm Hg. Chest X-ray revealed diffuse interstitial changes. All the possible causes of unknown origin fever were excluded.Diagnosis was made through lung biopsy and treatment with combined chemotherapy and rituximab was prescribed leading to a 48 hours clinical remission. We present this case to show how difficult this diagnosis can be and how a good response to therapy is possible. Resumo: O linfoma intravascular é uma forma muito rara de linfoma não Hodgkin de células grandes B. Caracteriza-se pela proliferação celular tumoral de linfócitos limitada aos pequenos vasos, particularmente nos capilares. Apresentamos o caso de uma doente de 54 anos, não fumadora, que foi admitida no nosso hospital para investigação de um quadro com quatro meses de evolução de febre, sudorese nocturna, ema-grecimento não quantificado e dispneia progressiva. Ao exame objectivo apresentava-se febril, taquicárdica e polipneica. Analiticamente, destacava-se anemia, leucocitose e LDH elevada. Gasometria arterial - FiO2 1 l/m: PaO2-63,6 mm Hg. A telerradiografia de tórax revelava infiltado intersticial difuso. Foram excluídas todas as causas de febre de origem indeterminada. O diagnóstico foi realizado por biópsia pulmonar cirúrgica e foi prescrita terapêutica citostática combinada e rituximab com boa resposta cl

  6. Seismic site coefficients and acceleration design response spectra based on conditions in South Carolina : final report.

    Science.gov (United States)

    2014-11-15

    The simplified procedure in design codes for determining earthquake response spectra involves : estimating site coefficients to adjust available rock accelerations to site accelerations. Several : investigators have noted concerns with the site coeff...

  7. How One Award-Winning Newspaper Reports the Big Story Responsibly.

    Science.gov (United States)

    Ferentinos, Nick

    1986-01-01

    Discusses the school newspaper of Westlake High School in Austin, Texas, which regularly features "hard" news stories and how, as a result, the students have learned the responsibility and honesty involved in ethical journalism. (SRT)

  8. Responses of women and men to traffic safety messages : a qualitative report

    Science.gov (United States)

    1994-02-01

    More information about receptivity to traffic safety communications is needed to develop effective media campaigns for women. This project sought to obtain such information through (1) a review of literature on gender differences in response to traff...

  9. An analysis of survey reporting in the imaging professions: Is the issue of non-response bias being adequately addressed?

    International Nuclear Information System (INIS)

    Lewis, Emily F.; Hardy, Maryann; Snaith, Beverly

    2013-01-01

    Background: Surveys are a common method of data collection within health service research. An essential aspect of reporting survey research is ensuring that sufficient information is provided to enable readers to determine the validity and representativeness of research findings. Method: This study reports a secondary analysis of survey research published in Radiography and Clinical Radiology between 2001 and 2010. The purpose of the study was to evaluate trends in response rates and establish how non-response bias was being addressed. Results: Analysis of non-response bias was undertaken in 9.4% (n = 9/96) of studies. Where analysis was performed, strong reliance on demographic characteristics to determine sample representativeness was noted (n = 8/9; 88.9%). Conclusion: The findings of this study suggest that non-response bias is not being adequately addressed within published imaging related survey research and more needs to be done to encourage a rigorous approach to the analysis and reporting of survey results

  10. 2002 ECR annual report : the annual report of the Environmental Commitment and Responsibility Program of the Canadian Electricity Association : Canadian electricity and the environment

    International Nuclear Information System (INIS)

    2003-10-01

    This annual report provides a comprehensive review of the Canadian electricity industry's environmental performance in 2002. The Canadian Electricity Association launched the Environmental Commitment and Responsibility (ECR) Program in 1997 as part of an industry-wide strategy to report on environmental performance. The initiatives of individual member utilities are reported in an effort to demonstrate the industry's commitment to sustainable development and better environmental performance. This annual report focuses on air quality issues for the electricity industry with emphasis on energy efficiency. It presents 4 principle initiatives: (1) efficiency in terms of resources requires measures such as improved energy conservation and efficiency of fossil fuel generating stations, and internal energy efficiency regarding power generation, power transmission, and power distribution. It also includes efforts by member utilities to reuse insulating oil and use solid combustion by-products, (2) reduce environmental impacts of power generation in terms of atmospheric emissions of carbon dioxide, sulphur dioxide, and nitrogen oxides. These initiatives include spill and PCB management, (3) accountability to constituents in terms of public reporting on environmental performance, and (4) ensure that employees understand the environmental implications of their actions. The report also discusses the use of treated wood poles and species at risk. tabs., figs

  11. Report of the Defense Science Board Task Force on University Responsiveness to National Security Requirements.

    Science.gov (United States)

    1982-01-01

    R.ugustine Chairman iv OFFICE OF THE SECRETARY OF DEFENSE WASHINGTON, D.C. 20301 27 January 1982 DEFENSE SCIENCIE BOARD Mr. Norman R. Augustine Chai rman...critical needs for special attention. Responsible Office: DUSD(R&AT) 3. The USDRE direct the Defense Acquisition Regulations Committee to revise current...Responsible Office: DUSD(R&AT) 4. The USORE direct Services to provide funding to the universities for a sustained period, over and above 6.1 Research

  12. Evaluation of the reporting completeness and timeliness of the integrated disease surveillance and response system in northern Ghana.

    Science.gov (United States)

    Adokiya, Martin Nyaaba; Awoonor-Williams, J Koku; Beiersmann, Claudia; Müller, Olaf

    2016-03-01

    The integrated disease surveillance and response (IDSR) and district health information management system II (DHIMS2) strategies were implemented in 2002 and 2012 respectively to improve surveillance data reporting and quality. The objective of this study was to evaluate the reporting completeness and timeliness of the IDSR system at the sub-national level in northern Ghana. This was an observational study in Upper East Region (UER). Weekly and monthly disease surveillance reports on completeness and timeliness were downloaded and analysed for 2012 and 2013 from the DHIMS2 in UER, the two Kassena-Nankana districts and their nine health facilities representing public, private and mission providers. Comparison of paper-based and DHIMS2 reporting from the periphery health facilities were assessed. IDSR monthly reporting completeness and timeliness in UER increased by 9% and 37% respectively in 2013 compared to 2012 and weekly completeness and timeliness improved by 79% and 24% respectively in 2013. Similar reporting increases were seen in the districts and health facilities over the same period, except the Kassena-Nankana Municipal which showed decrease of 2% in monthly completeness for 2013. At the health facilities, the paper-based reporting completeness was 96% and timeliness 45% while DHIMS2 completeness was 83% and timeliness 18% in 2012. However, DHIMS2 reporting completeness and timeliness improved in 2013 reaching 100% and 61% respectively. Disease surveillance reporting through DHIMS2 became more complete over time, but there remain problems with timeliness. Surveillance data need to be timely to enable rapid responses to disease outbreaks.

  13. 12 CFR 630.4 - Responsibilities for preparing the report to investors.

    Science.gov (United States)

    2010-01-01

    ... the Funding Corporation for preparation of the report. The financial information provided by the... information, and related analysis as are required by this part to make the reports meaningful and not... information needed for preparation of the Systemwide combined financial statements and disclosures required to...

  14. Australian Undergraduate Primary School Student-Teachers' Responses to Child Sexual Abuse and Its Mandatory Reporting

    Science.gov (United States)

    Goldman, Juliette D. G.

    2010-01-01

    This study aims to understand how primary school teachers, as mandatory reporters of child sexual abuse, are responding to child sexual abuse and its mandatory reporting, even though many teachers do not receive a compulsory course in Child Protection and its legal requirements in their pre-service university training. A cohort of 81 Australian…

  15. Self-Reported Learning Gains: A Theory and Test of College Student Survey Response

    Science.gov (United States)

    Porter, Stephen R.

    2013-01-01

    Recent studies have asserted that self-reported learning gains (SRLG) are valid measures of learning, because gains in specific content areas vary across academic disciplines as theoretically predicted. In contrast, other studies find no relationship between actual and self-reported gains in learning, calling into question the validity of SRLG. I…

  16. Development of an extended framework for emergency response criteria. Interim report for comments

    International Nuclear Information System (INIS)

    2005-01-01

    Experience from response to recent nuclear and radiological emergencies has clearly demonstrated the importance of an efficient response system that includes, among other components, emergency plans, procedures, and internally consistent operational criteria. An analysis of lessons identified from recent responses has shown that a lack of crucial components in the emergency response system could result in major radiological and nonradiological consequences at the national level. One of the reasons for the overwhelming psychological consequences of the Chernobyl and Goiania emergencies was public mistrust of decision-makers, who lost their credibility by frequently changing the criteria for taking action. Moreover, national response arrangements that are incompatible among countries can result in major mistrust by the public. It is considered important to have internationally agreed criteria and guidance for emergency response established in advance of an emergency. Currently there are several IAEA safety standards that contain recommendations for response to radiation emergencies, addressing principles and response criteria. Mindful of the lessons identified from recent emergencies, the IAEA convened in November 2001 a technical committee meeting (TCM) to develop aspects of the technical basis for emergency response to radiation emergencies. At this meeting, the lessons from response to the Chernobyl, Goiania and other emergencies over the past years were examined to identify where revisions were needed to the existing international guidance for response. In particular, the existing international criteria and guidance for taking protective and other actions were examined in the light of these lessons. The objectives of this document are: (1) to propose an extension of existing criteria for undertaking protective and other actions during or following a nuclear or radiological emergency that: addresses the lessons from past emergencies, addresses the recently

  17. Seismic shear wall ISP NUPEC's seismic ultimate dynamic response test. Comparison report

    International Nuclear Information System (INIS)

    1996-01-01

    In the seismic design of a nuclear power plant, evaluation of the ultimate strength of the nuclear reactor building is an important subject for assessment of seismic reliability of the plant. In order to carry out the evaluation, the response characteristics of reinforced concrete seismic shear walls up to their ultimate state have to be understood. For this purpose, there is a need to develop reliable non-linear response analysis methods which enables the reliable ultimate strength evaluation of nuclear reactor buildings. Along with this need, many computer codes have been developed. These computer codes are compared. (K.A.)

  18. An uncommon response to metronomic therapy in a heavily pretreated patient with metastatic carcinosarcoma: a case report.

    Science.gov (United States)

    Gagliato, Debora de Melo; Linck, Rudinei Diogo Marques; Bezerra, Regis Otaviano Franca; Souto, Mirela; Lopes, Gabriel Lima; Baiocchi, Glauco; Mano, Max Senna

    2016-03-14

    Uterine carcinosarcoma is well known for its aggressive behavior. There is little evidence regarding the gold standard combination chemotherapy in metastatic or locally advanced carcinosarcoma, due to poor survival outcomes obtained with conventional scheduled chemotherapy. This case report represents the first-ever reported objective response to a metronomic chemotherapy regimen and adds to the current literature. We describe a case of a Caucasian woman diagnosed with metastatic carcinosarcoma that had already been treated with multiple lines of conventional chemotherapy, with progressive disease. This patient had a surprising clinical and imaging response when treated with oral metronomic cyclophosphamide. We reviewed the mechanism of action implicated in metronomic chemotherapy, and correlated it with the biology of disease in carcinosarcoma. This information may add to the current literature, providing important insights to future clinical trials in this patient population.

  19. Wyoming Department of Transportation (WYDOT) road condition reporting application for weather responsive traffic management.

    Science.gov (United States)

    2016-01-01

    FHWAs Road Weather Management Program partnered : with WYDOT to develop a new software application to : improve the way maintenance personnel report road and : weather conditions to their statewide Transportation : Management Center (TMC), recomme...

  20. Department of the Navy Family Advocacy Program: Service Need and Service Response. Phase II Report: Assessment

    Science.gov (United States)

    1983-08-01

    cases where physical injuries are minimal, or in sexual assualt and rape cases when victims reports the incident days after the attack. In the latter case...Military Family Advocacy; Child Abuse; Spouse Abuse; Sexual Assault; Rape 20. ABSTRACT (Contnue on reverse If neeoery and Identify by block number...child abuse, spouse abuse, and sexual assault or rape. The report also identifies program needs and recommendations for program inmrovement. Findings

  1. Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen Report.

    Directory of Open Access Journals (Sweden)

    Mirko Manchia

    Full Text Available The assessment of response to lithium maintenance treatment in bipolar disorder (BD is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the "Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder" scale currently used in the Consortium on Lithium Genetics (ConLiGen study.Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa (κ] and reliability [intra-class correlation coefficient (ICC] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment response scores available for 1,308 patients using mixture modeling.Substantial and moderate agreement was shown across sites in the first and second sets of vignettes (κ = 0.66 and κ = 0.54, respectively, without significant improvement from training. However, definition of response using the A score as a quantitative trait and selecting cases with B criteria of 4 or less showed an improvement between the two stages (ICC1 = 0.71 and ICC2 = 0.75, respectively. Mixture modeling of score distribution indicated three subpopulations (full responders, partial responders, non responders.We identified two definitions of lithium response, one dichotomous and the other continuous, with moderate to substantial inter-rater agreement and reliability. Accurate phenotypic measurement of lithium response is crucial for the ongoing ConLiGen pharmacogenomic study.

  2. The response of the Government of Ontario to the final report of the Royal Commission on Electric Power Planning

    International Nuclear Information System (INIS)

    1981-05-01

    In March 1980, after nearly five years of hearings and research, the Ontario Royal Commission on Electric Power Planning submitted the first volume of its final report. The remaining eight volumes were submitted in April 1980. The Commission made 88 recommendations on technical, operational, and policy issues. The present document sets out the Ontario government's response to the recommendations. The government accepts and is implementing 77 recommendations. Four recommendations require further study, and six have been rejected

  3. Reasoning and Negotiation about Child Responsibility in Urban Chinese Families: Reports from Mothers, Fathers and Children

    Science.gov (United States)

    Bowes, Jennifer M.; San, Li Qing; Chen, May-Jane; Yuan, Li

    2004-01-01

    The study investigates everyday parental practices involved in the transmission of cultural values and extends current literature on parenting in Chinese families. Children aged 6, 8, and 10 years from 240 Beijing families, and both their parents, were asked about ways in which expectations of child responsibility are transmitted through routine…

  4. Progress report for project modeling Arctic barrier island-lagoon system response to projected Arctic warming

    Science.gov (United States)

    Erikson, Li H.; Gibbs, Ann E.; Richmond, Bruce M.; Storlazzi, Curt; B.M. Jones,

    2012-01-01

    Changes in Arctic coastal ecosystems in response to global warming may be some of the most severe on the planet. A better understanding and analysis of the rates at which these changes are expected to occur over the coming decades is crucial in order to delineate high-priority areas that are likely to be affected by climate changes. In this study we investigate the likelihood of changes to habitat-supporting barrier island – lagoon systems in response to projected changes in atmospheric and oceanographic forcing associated with Arctic warming. To better understand the relative importance of processes responsible for the current and future coastal landscape, key parameters related to increasing arctic temperatures are investigated and used to establish boundary conditions for models that simulate barrier island migration and inundation of deltaic deposits and low-lying tundra. The modeling effort investigates the dominance and relative importance of physical processes shaping the modern Arctic coastline as well as decadal responses due to projected conditions out to the year 2100.

  5. A Bayesian Approach to Person Fit Analysis in Item Response Theory Models. Research Report.

    Science.gov (United States)

    Glas, Cees A. W.; Meijer, Rob R.

    A Bayesian approach to the evaluation of person fit in item response theory (IRT) models is presented. In a posterior predictive check, the observed value on a discrepancy variable is positioned in its posterior distribution. In a Bayesian framework, a Markov Chain Monte Carlo procedure can be used to generate samples of the posterior distribution…

  6. Estimating Multidimensional Item Response Models with Mixed Structure. Research Report. ETS RR-05-04

    Science.gov (United States)

    Zhang, Jinming

    2005-01-01

    This study derived an expectation-maximization (EM) algorithm for estimating the parameters of multidimensional item response models. A genetic algorithm (GA) was developed to be used in the maximization step in each EM cycle. The focus of the EM-GA algorithm developed in this paper was on multidimensional items with "mixed structure."…

  7. Measurement Error in Nonparametric Item Response Curve Estimation. Research Report. ETS RR-11-28

    Science.gov (United States)

    Guo, Hongwen; Sinharay, Sandip

    2011-01-01

    Nonparametric, or kernel, estimation of item response curve (IRC) is a concern theoretically and operationally. Accuracy of this estimation, often used in item analysis in testing programs, is biased when the observed scores are used as the regressor because the observed scores are contaminated by measurement error. In this study, we investigate…

  8. Stimulus-Response Theory of Finite Automata, Technical Report No. 133.

    Science.gov (United States)

    Suppes, Patrick

    The central aim of this paper and its projected successors is to prove in detail that stimulus-response theory, or at least a mathematically precise version, can give an account of the learning of many phrase-structure grammars. Section 2 is concerned with standard notions of finite and probabilistic automata. An automaton is defined as a device…

  9. Reported goals of instructors of responsible conduct of research for teaching of skills.

    Science.gov (United States)

    Plemmons, Dena K; Kalichman, Michael W

    2013-04-01

    The National Institutes of Health (NIH) training grant requirement to provide training in the responsible conduct of research (RCR) is now more than 20 years old. Implicit in the requirement is that this training will have an impact not only on what trainees know, but on what they know how to do. There is, however, a range of responses about what skills are seen to be necessary for the ethical practice of science. As part of a larger, earlier study examining RCR instructors' overall goals in teaching RCR, we asked 50 RCR instructors from 37 different institutions what their goals were for teaching skills in their RCR courses. The responses about what constituted necessary skills were wide ranging, from a focus on teaching the skill of ethical decision making to the perceived importance of ensuring that trainees understand the importance of the community in some research relationships. This diversity in responses about what skills should be taught in RCR courses is not especially surprising, given the variation in instructors, formats, instruction, goals, and outcome measures for RCR courses, but it does reinforce the necessity of giving more thought to what goals are to be achieved. This is true not only of skills to be learned, but of any other objectives one might have for research ethics teaching and learning.

  10. Scalable Emergency Response System for Oceangoing Assets Report on Defining Proposed Program

    Science.gov (United States)

    2008-10-17

    purpose, two genotypic approaches for pathogen detection , namely polymerase chain reaction ( PCR ) based pathogen identification and microarrays, were...Waterborne Pathogenic E. coli Gastroenteritis Water- foodborne Yersinia enterocolitica Gastroenteritis Waterborne Campylobacter jejuni Gastroenteritis... detection and decontamination of a single piece of equipment before it is loaded on a vessel, to the response, rescue, containment and rehabilitation of a

  11. Terra-Kleen Response Group, Inc. Solvent Extraction Technology Rapid Commercialization Initiative Report

    Science.gov (United States)

    Terra-Kleen Response Group Inc. (Terra-Kleen), has commercialized a solvent extraction technology that uses a proprietary extraction solvent to transfer organic constituents from soil to a liquid phase in a batch process at ambient temperatures. The proprietary solvent has a rel...

  12. The Cortisol Awakening Response Mediates the Relationship Between Acculturative Stress and Self-Reported Health in Mexican Americans.

    Science.gov (United States)

    Garcia, Antonio F; Wilborn, Kristin; Mangold, Deborah L

    2017-12-01

    The assessment of acculturative stress as synonymous with acculturation level overlooks the dynamic, interactive, and developmental nature of the acculturation process. An individual's unique perception and response to a range of stressors at each stage of the dynamic process of acculturation may be associated with stress-induced alterations in important biological response systems that mediate health outcomes. Evidence suggests the cortisol awakening response (CAR) is a promising pre-clinical biomarker of stress exposure that may link acculturative stress to self-reported health in Mexican Americans. The aim of the current study was to examine whether alterations in the CAR mediate the relationship between acculturative stress and self-reported health in Mexican Americans. Salivary cortisol samples were collected at awakening, 30, 45, and 60 min thereafter, on two consecutive weekdays from a sample of adult Mexican Americans. Acculturative stress and self-reported health were assessed. Data were aggregated and analyzed (n = 89) using a mixed effects regression model and path analysis. Poorer self-reported health was associated with attenuated CAR profiles (primarily due to a diminished post-awakening rise in cortisol) predicted by both moderate and high levels of exposure to acculturative stress. Stress-induced alterations in the CAR mediated the relationship between exposure to acculturative stressors and self-reported health. Findings demonstrate that different levels of acculturative stress are associated with distinct CAR profiles and suggest the CAR is one possible biological pathway through which exposure to culturally unique stressors may be linked to health disparities.

  13. Thiamine-responsive megaloblastic anemia syndrome with Ebstein anomaly: a case report.

    Science.gov (United States)

    Akbari, Mohammad Taghi; Zare Karizi, Shohreh; Mirfakhraie, Reza; Keikhaei, Bijan

    2014-12-01

    Thiamine-responsive megaloblastic anemia (TRMA) or Roger syndrome is a rare autosomal recessive disorder characterized by the occurrence of multiple clinical manifestations including megaloblastic anemia, diabetes mellitus, and sensorineural deafness. A few patients have been also described with congenital cardiac malformations. The patients usually respond to treatment with pharmacological doses of thiamine. Mutations in the SLC19A2 gene, located at chromosome 1q24.2, are responsible for this syndrome. Here, we present two new Iranian TRMA patients who were homozygous for c.697C > T mutation in the SLC19A2 gene. On follow-up, one of the patients showed Ebstein anomaly. The present study confirms the variability of the clinical manifestations caused by the same mutation within patients with TRMA syndrome. Therefore, follow-up of the affected children should be considered.

  14. Comment and response document for the UMTRA Project vitro processing site completion report Salt Lake City, Utah. Revision 1

    International Nuclear Information System (INIS)

    1995-03-01

    This Comment and Response Document is a series of UMTRA document review forms regarding the UMTRA Project Vitro Processing Site Completion Report for Salt Lake City, Utah in March, 1995. The completion report provides evidence that the final Salt Lake City, Utah, processing site property conditions are in accordance with the approved design and that all U.S. Environmental Protection Agency (EPA) standards have been satisfied. Included as appendices to support the stated conclusions are the record drawings; a summary of grid test results; contract specifications and construction drawings, the EPA standards (40 CFR Part 192); the audit, inspection, and surveillance summary; the permit information; and project photographs. The principal objective of the remedial action at Salt Lake City is to remove the tailings from the processing site, render the site free of contamination to EPA standards, and restore the site to the final design grade elevations. Each section is evaluated in detail to check all aspects of above report, especially the inclusion of adequate verification data. Each review form contains a section entitled State of Utah Response and Action, which is an explanation or correction of DOE criticisms of the report

  15. Final Report [Function of the Arabidopsis TIR1 gene in auxin response

    Energy Technology Data Exchange (ETDEWEB)

    Estelle, Mark

    2000-12-18

    During this grant period substantial progress was made in the characterization of the TIR1 gene in Arabidopsis. Studies showed that the TIR1 protein is part of a protein complex that includes AtCUL1, ASK1 and RBX1. This complex, called SCF-TIR1, functions in the ubiquitin-mediated protein degradation pathway. Our work is the first report of an SCF complex in a plant system. The results of our studies are described in more detail in the report together with a publication resulting from this study.

  16. Reporter gene assay for the quantification of the activity and neutralizing antibody response to TNFα antagonists

    DEFF Research Database (Denmark)

    Lallemand, Christophe; Kavrochorianou, Nadia; Steenholdt, Casper

    2011-01-01

    A cell-based assay has been developed for the quantification of the activity of TNFα antagonists based on human erythroleukemic K562 cells transfected with a NFκB regulated firefly luciferase reporter-gene construct. Both drug activity and anti-drug neutralizing antibodies can be quantified...... with a high degree of precision within 2h, and without interference from cytokines and other factors known to activate NFκB. The assay cells also contain the Renilla luciferase reporter gene under the control of a constitutive promoter that allows TNFα-induced firefly luciferase activity to be normalized...

  17. Preadolescents' Emotional and Prosocial Responses to Negative TV News: Investigating the Beneficial Effects of Constructive Reporting and Peer Discussion.

    Science.gov (United States)

    Kleemans, Mariska; Schlindwein, Luise F; Dohmen, Roos

    2017-09-01

    Watching news is important for preadolescents, but it may also harm their well-being. This study examined whether applying insights from positive psychology to news production can reduce this potential harm, by reducing negative emotional responses and enhancing positive emotional responses to negative news, and by encouraging prosocial intentions. Moreover, we explored whether peer discussion strengthened these effects. Preadolescents (n = 336; 9-13 years old; 48.5% female) were exposed to either constructive (solution-based news including positive emotions) or nonconstructive news. Subsequently, half of the children assigned to the constructive and the nonconstructive condition participated in a peer discussion. The findings showed that exposure to constructive news resulted in more positive emotional responses and less negative emotional responses as compared to nonconstructive news. Moreover, discussing the news with peers led to more positive and less negative emotional responses among preadolescents who watched the nonconstructive newscast, and to more prosocial intentions among preadolescents who watched constructive news. In all, constructive news reporting and peer discussion could function as tools to make negative news less harmful for preadolescents.

  18. Site-dependent bone mineral density response to oral pamidronate and calcium in postmenopausal osteoporosis: a preliminary report.

    Science.gov (United States)

    Barreira, J C; Messina, O D; Maldonado-Cocco, J A; Roldan, E J

    1997-06-01

    Radiologically diagnosed postmenopausal osteoporotic patients with at least one nontraumatic vertebral flattening were treated for one year with either oral pamidronate (APD), 300 mg/day plus calcium 1 g/day (n=39) or with calcium alone (n=21). Bone mineral density (BMD) was assessed in lumbar spine, femoral neck, trochanter and Ward's triangle by dual X-ray absorptiometry in order to determine the number of responders at each site. As no densitometric inclusion criteria were stipulated, wide inter- and intra-individual variations in both regional basal BMD and response to therapy were found. However, the APD-treated group showed significant mean BMD increases in spine (+3.1%; p cases, 9 (24%) on APD and 6 (32%) on calcium alone responded in all 4 areas evaluated, while a single case on the latter treatment failed to show BMD response at any site. Overall, the mean number of responsive sites was 2.7. Odds ratios were calculated considering treatment modality and high or low basal BMD as parameters, but no significant differences were found in the number of responders. It may be concluded that APD induces moderate lumbar and femoral neck bone mass gain in severe postmenopausal osteoporosis, whereas calcium alone leads to non significant variations, both findings being in agreement with reported data. Therefore, evaluated APD doses enhance mineralization in responsive sites alone, but fail to increase the total number of responders. Interestingly, responsive sites seem to be those relitively spared by the course of the disease.

  19. Oral Ezatiostat HCl (TLK199) and Myelodysplastic syndrome: a case report of sustained hematologic response following an abbreviated exposure.

    Science.gov (United States)

    Quddus, Fahd; Clima, Jessica; Seedham, Helen; Sajjad, Ghulam; Galili, Naomi; Raza, Azra

    2010-04-23

    Treatment options for patients with lower risk non-del(5q) myelodysplastic syndromes (MDS) who fail erythroid stimulating agents are restricted to one of the hypomethylating drugs with an expected response rate of approximately 50%. Ezatiostat HCl, an agent with the potential for producing multi-lineage responses in this population is currently in clinical investigation phase. This case report describes a 77 year old male who received less than two cycles of therapy with ezatiostat HCl which had to be aborted due to intolerable side effects, but which produced a sustained normalization of all three blood counts. This trilineage response has now lasted for more than a year. Interestingly, the patient began with a del(5q) abnormality and responded briefly to lenalidomide. Upon relapse of the anemia, a bone marrow showed the disappearance of the del(5q) but the appearance of a new clonal abnormality t(2;3). Given that the patient had a complete cytogenetic response to a truncated exposure to lenalidomide followed by a trilineage response to an even briefer course of ezatiostat HCl suggests a potential role for ezatiostat HCl in del(5q) patients who relapse following lenalidomide.

  20. Patient-Reported Outcome Measures for Hand and Wrist Trauma: Is There Sufficient Evidence of Reliability, Validity, and Responsiveness?

    Science.gov (United States)

    Dacombe, Peter Jonathan; Amirfeyz, Rouin; Davis, Tim

    2016-03-01

    Patient-reported outcome measures (PROMs) are important tools for assessing outcomes following injuries to the hand and wrist. Many commonly used PROMs have no evidence of reliability, validity, and responsiveness in a hand and wrist trauma population. This systematic review examines the PROMs used in the assessment of hand and wrist trauma patients, and the evidence for reliability, validity, and responsiveness of each measure in this population. A systematic review of Pubmed, Medline, and CINAHL searching for randomized controlled trials of patients with traumatic injuries to the hand and wrist was carried out to identify the PROMs. For each identified PROM, evidence of reliability, validity, and responsiveness was identified using a further systematic review of the Pubmed, Medline, CINAHL, and reverse citation trail audit procedure. The PROM used most often was the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire; the Patient-Rated Wrist Evaluation (PRWE), Gartland and Werley score, Michigan Hand Outcomes score, Mayo Wrist Score, and Short Form 36 were also commonly used. Only the DASH and PRWE have evidence of reliability, validity, and responsiveness in patients with traumatic injuries to the hand and wrist; other measures either have incomplete evidence or evidence gathered in a nontraumatic population. The DASH and PRWE both have evidence of reliability, validity, and responsiveness in a hand and wrist trauma population. Other PROMs used to assess hand and wrist trauma patients do not. This should be considered when selecting a PROM for patients with traumatic hand and wrist pathology.

  1. Value relevance and corporate responsibility reporting in the South African context: An alternate view post King-III

    Directory of Open Access Journals (Sweden)

    Adrian Marcia

    2015-11-01

    Full Text Available This study tests for the value relevance of corporate responsibility reporting (CRR based on a sample of companies listed on the Johannesburg Stock Exchange (JSE. It also provides evidence of the statistical significance of the potential contribution of CRR to share price values in the South African context at a particular point. On the basis of a sample of 82 companies on the JSE, hierarchical regression analysis was used to test the contribution of levels of corporate social responsibility disclosures to company share prices, over and above the contribution of the size of a firm’s equity and net income. In contrast with other findings which predict a positive relationship between company share price and levels of corporate social responsibility disclosures, the latter are found to have no significant association with company share price over and above the associations of the size of a firm’s equity and net income. Bivariate associations, however, indicate a significant association between share price and levels of corporate social responsibility disclosures. On the basis of these findings, it is argued that disclosures increase for firms with larger endowments of equity, yet corporate social responsibility disclosures do not necessarily add value to company share price.

  2. 2015 QuickCompass of Sexual Assault Prevention and Response-Related Responders (QSAPR). Overview Report

    Science.gov (United States)

    2016-03-01

    education so SARCs and VAs can maximize the tools they have for supporting male survivors of sexual assault. Familiarity with SAPRO Resources...an area where ongoing education about the value of the SVC/VLC program may ultimately bolster support options for survivors of sexual assault...Lower Response SARCs Demonstrate awareness of the impact of sexual assault on survivors 85 83 87 81 91 Facilitate education and training 82 81 77

  3. STRUCTURAL FLUCTUATIONS, ELECTRICAL RESPONSE AND THE RELIABILITY OF NANOSTRUCTURES (FINAL REPORT)

    Energy Technology Data Exchange (ETDEWEB)

    Philip J. Rous; Ellen D. Williams; Michael S. Fuhrer

    2006-07-31

    The goal of the research supported by DOE-FG02-01ER45939 was to synthesize a number of experimental and theoretical approaches to understand the relationship between morphological fluctuations, the electrical response and the reliability (failure) of metallic nanostructures. The primary focus of our work was the study of metallic nanowires which we regard as prototypical of nanoscale interconnects. Our research plan has been to link together these materials properties and behaviors by understanding the phenomenon of, and the effects of electromigration at nanometer length scales. The thrust of our research has been founded on the concept that, for nanostructures where the surface-to-volume ratio is necessarily high, surface diffusion is the dominant mass transport mechanism that governs the fluctuations, electrical properties and failure modes of nanostructures. Our approach has been to develop experimental methods that permit the direct imaging of the electromagnetic distributions within nanostructures, their structural fluctuations and their electrical response. This experimental research is complemented by a parallel theoretical and computational program that describes the temporal evolution of nanostructures in response to current flow.

  4. Visualization of resistance responses in Phaseolus vulgaris using reporter tagged clones of Bean common mosaic virus

    DEFF Research Database (Denmark)

    Naderpour, Masoud; Johansen, Ida Elisabeth

    2011-01-01

    Reporter tagged virus clones can provide detailed information on virus–host interactions. In Phaseolus vulgaris (bean), four recessive and one dominant gene are known to control infection by strains of the potyvirus species Bean common mosaic virus (BCMV). To study the interactions between BCMV...

  5. Post eclipse thermal response of Uranian satellites with SINFONI: a status report .

    NARCIS (Netherlands)

    Maris, M.; Hestroffer, D.; Delbo, M.; Mueller, M.; Grundy, W.; Stansberry, J.; Tozzi, G. P.; Tanga, P.; Thuillot, W.

    2008-01-01

    We report on the status of a project to measure eclipse-induced changes in surface temperature on the major Uranian satellites. Such measurements enable a uniquely direct determination of the thermal inertia, a measure of the resistance to changes in surface temperature. Thermal inertia is a very

  6. Community Response to Homelessness: Evaluation of the HACAP Transitional Housing Program. Final Report.

    Science.gov (United States)

    Richardson, Brad B.; Landsman, Miriam J.

    The causes and consequences of homelessness have been the subject of considerable social science research. This report details recovery from homelessness, or "exits from homelessness," through analysis of descriptive demographic data and correlation of success rates with participant behavior and intervention context. The 2-year…

  7. Ghana taking steps to reduce poverty in response to report on fuel ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    31 janv. 2014 ... A recent study on fuel subsidies in Ghana has confirmed that government aid has disproportionately benefited the country's wealthiest group. The report from the Partnership for Economic Policy (PEP) and UNICEF-Ghana highlights how 80% of fuel subsidies goes to the country's wealthiest, while Ghana's ...

  8. Reporter gene assay for the quantification of the activity and neutralizing antibody response to TNFα antagonists

    DEFF Research Database (Denmark)

    Lallemand, Christophe; Kavrochorianou, Nadia; Steenholdt, Casper

    2011-01-01

    A cell-based assay has been developed for the quantification of the activity of TNFa antagonists based on human erythroleukemic K562 cells transfected with a NF¿B regulated firefly luciferase reporter-gene construct. Both drug activity and anti-drug neutralizing antibodies can be quantified...

  9. Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy.

    Science.gov (United States)

    Press, Craig A; Knupp, Kelly G; Chapman, Kevin E

    2015-04-01

    Oral cannabis extracts (OCEs) have been used in the treatment of epilepsy; however, no studies demonstrate clear efficacy. We report on a cohort of pediatric patients with epilepsy who were given OCE and followed in a single tertiary epilepsy center. A retrospective chart review of children and adolescents who were given OCE for treatment of their epilepsy was performed. Seventy-five patients were identified of which 57% reported any improvement in seizure control and 33% reported a >50% reduction in seizures (responders). If the family had moved to CO for OCE treatment, the responder rate was 47% vs. 22% for children who already were in CO. The responder rate varied based on epilepsy syndrome: Dravet 23%, Doose 0%, and Lennox-Gastaut syndrome (LGS) 88.9%. The background EEG of the 8 responders where EEG data were available was not improved. Additional benefits reported included: improved behavior/alertness (33%), improved language (10%), and improved motor skills (10%). Adverse events (AEs) occurred in 44% of patients including increased seizures (13%) and somnolence/fatigue (12%). Rare adverse events included developmental regression, abnormal movements, status epilepticus requiring intubation, and death. Our retrospective study of OCE use in pediatric patients with epilepsy demonstrates that some families reported patient improvement with treatment; however, we also found a variety of challenges and possible confounding factors in studying OCE retrospectively in an open-labeled fashion. We strongly support the need for controlled, blinded studies to evaluate the efficacy and safety of OCE for treatment of pediatric epilepsies using accurate seizure counts, formal neurocognitive assessments, as well as EEG as a biomarker. This study provides Class III evidence that OCE is well tolerated by children and adolescents with epilepsy. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Review and Response to the Final Report of the National Black Health Providers Task Force on High Blood Pressure Education and Control.

    Science.gov (United States)

    Public Health Service (DHHS), Rockville, MD.

    This report presents the National Heart, Lung, and Blood Institute's (NHLBI) review of and response to the final report of the National Black Health Providers Task Force on High Blood Pressure Education and Control. The response includes a statement of NHLBI's involvement in health research, and descriptions of what steps can be taken to solve the…

  11. Autoimmune hemolytic anemia after nivolumab treatment in Hodgkin lymphoma responsive to immunosuppressive treatment. A case report.

    Science.gov (United States)

    Tardy, Magalie P; Gastaud, Lauris; Boscagli, Annick; Peyrade, Frederic; Gallamini, Andrea; Thyss, Antoine

    2017-12-01

    The patients with refractory Hodgkin lymphoma have a poor prognosis. The nivolumab, an IgG4 monoclonal antibody inhibiting the program death 1 pathway has recently demonstrated its efficacy and its safety in patients with heavily pretreated refractory Hodgkin lymphoma. The side effects of this immunotherapy include autoimmune-like syndromes. A 75-year-old woman with no significant comorbidities was treated by nivolumab (3 mg/kg every 2 wk) as a third-line treatment for refractory Hodgkin lymphoma. A clinical response was observed with the first injection of nivolumab, with a reduction in superficial lymph nodes. After the second injection, the patient presented an authentic autoimmune hemolytic anemia with a profound anemia at 64 g/L and biologic characteristics of hemolysis (elevated unconjugated bilirubin, lactate dehydrogenase, and reticulocytes). The direct antiglobulin test was strongly positive for IgG antibodies, and the indirect antiglobulin test became positive with a very high level of autoantibodies. After 2 injections of nivolumab, the patient underwent a fluodeoxyglucose F 18 positron emission tomography-computed tomography, showing a partial response according to modified Cheson criteria. A treatment with prednisone (2 mg/kg), initiated after transfusion of 2 units of red blood cells, permitted the complete resolution of this autoimmune reaction after 3 months of corticotherapy. The fluodeoxyglucose F 18 positron emission tomography-computed tomography performed at the end of the corticotherapy showed a clear disease progression. Considering the very good response achieved after only 2 injections of nivolumab, the limited therapeutic resources for this old woman, and the complete resolution of the autoimmune hemolytic anemia, nivolumab was reintroduced at the same dose, with close clinical and biological monitoring. She received 6 more injections of nivolumab without recurrence of hemolysis. Copyright © 2016 John Wiley & Sons, Ltd.

  12. Inter-Individual Variability in Human Response to Low-Dose Ionizing Radiation, Final Report

    International Nuclear Information System (INIS)

    Rocke, David

    2016-01-01

    In order to investigate inter-individual variability in response to low-dose ionizing radiation, we are working with three models, 1) in-vivo irradiated human skin, for which we have a realistic model, but with few subjects, all from a previous project, 2) ex-vivo irradiated human skin, for which we also have a realistic model, though with the limitations involved in keeping skin pieces alive in media, and 3) MatTek EpiDermFT skin plugs, which provides a more realistic model than cell lines, which is more controllable than human samples.

  13. Inter-Individual Variability in Human Response to Low-Dose Ionizing Radiation, Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Rocke, David [Univ. of California, Davis, CA (United States)

    2016-08-01

    In order to investigate inter-individual variability in response to low-dose ionizing radiation, we are working with three models, 1) in-vivo irradiated human skin, for which we have a realistic model, but with few subjects, all from a previous project, 2) ex-vivo irradiated human skin, for which we also have a realistic model, though with the limitations involved in keeping skin pieces alive in media, and 3) MatTek EpiDermFT skin plugs, which provides a more realistic model than cell lines, which is more controllable than human samples.

  14. A case of "refractory" lupus erythematosus profundus responsive to rituximab [case report].

    LENUS (Irish Health Repository)

    McArdle, Adrian

    2012-02-01

    Lupus erythematosus profundus is a rare complication of systemic lupus erythematosus characterized by the presence of deep, tender subcutaneous nodules. A 22-year-old African-American female with extensive lupus profundus resistant to conventional therapies was treated with two infusions of the anti-CD20 monoclonal antibody, rituximab, at a dosage of 1,000 mg each. The patient demonstrated a remarkable clinical response as indicated by the disappearance of the nodules. B-cell depletion therapy with rituximab used alone or in combination with other therapies may be a viable option in patients with lupus profundus refractory to current therapies.

  15. Molecular events basic to cellular radiation response. Progress report, July 1, 1976--September 30, 1977

    Energy Technology Data Exchange (ETDEWEB)

    Kolodny, G.M.

    1977-01-01

    Progress is reported on studies of the effects of x irradiation at the cellular level that lead ultimately to either malignant transformation or cell death. Experimental results consistent with the primer hypothesis for the regulation of gene expression in eukaryotes are reported. It was found that oligonucleotides can be inserted en bloc into newly synthesized RNA. Studies on amino acid-nucleic acid interactions were continued by successfully synthesizing an amidate and beginning NMR studies on the interactions between its nucleic acid and amino acid moieties. In studies on radiation induced giant cells in 3T3 cells growing in culture, it was demonstrated that conditions which potentiate potential lethal damage repair and those which prevent radiation induced giant cell formation exist. In an examination of the in vitro effects of vasopressin, no direct effect was found of vasopressin on radiation sensitivity and significant effects of radiation on lysosomal enzyme activity in cultured cells were found.

  16. The Cortisol Response to Anticipated Intergroup Interactions Predicts Self-Reported Prejudice

    OpenAIRE

    Bijleveld, E.H.; Scheepers, D.; Ellemers, N.

    2012-01-01

    OBJECTIVES: While prejudice has often been shown to be rooted in experiences of threat, the biological underpinnings of this threat-prejudice association have received less research attention. The present experiment aims to test whether activations of the hypothalamus-pituitary-adrenal (HPA) axis, due to anticipated interactions with out-group members, predict self-reported prejudice. Moreover, we explore potential moderators of this relationship (i.e., interpersonal similarity; subtle vs. bl...

  17. Sexual Harassment in Academic Medicine: Persistence, Non-Reporting, and Institutional Response

    OpenAIRE

    Wear, Delese; Aultman, Julie

    2009-01-01

    Sexual harassment occurs with regularity during medical training, and it remains largely unreported. This study is one institution’s attempt to understand how third and fourth-year medical students perceive and experience sexual harassment, what they believe about reporting sexual harassment, and how they believe it might be eradicated from the educational environment. We used a qualitative research method for our investigation, which would generate more specific language to use in a larger e...

  18. A Summary Case Report on the Health Impacts and Response to the Pakistan Floods of 2010

    Science.gov (United States)

    Shabir, Omar

    2013-01-01

    In July 2010, Pakistan suffered nationwide floods after unprecedented monsoon rains overwhelmed the Indus basin. The ensuing floods claimed 1985 lives, injured 2946 people and affected over 20.2 million people. Seventy-eight out of 121 districts were affected and at one stage one-fifth of the country’s land was inundated with water. Indiscriminate damage was caused to housing, educational and health facilities, communication networks, power plants and grids, irrigation channels, agricultural land and livestock. Over 37 million medical consultations were reported within one year of the floods with acute respiratory infection, skin diseases, acute diarrhoea and suspected malaria forming the most common presentations. Rescue and relief operations were organised through the National Disaster Management Authority and a UN Cluster Approach was adopted for providing humanitarian assistance. The Office for the Coordination of Humanitarian Affairs (OCHA) played a pivotal role in coordinating relief efforts between cluster groups and providing communication platforms for identifying gaps and sharing information. This paper attempts to collate information available in the public domain into a summary report based on key principles described by Kulling et al. (2010) on health crisis reporting. PMID:23591385

  19. Catholic Church Responses to Clergy-Child Sexual Abuse and Mandatory Reporting Exemptions in Victoria, Australia: A Discursive Critique

    Directory of Open Access Journals (Sweden)

    Michael Andre Guerzoni

    2015-12-01

    Full Text Available This article presents empirical findings from a critical discourse analysis of institutional responses by the Catholic Church to clergy-child sexual abuse in Victoria, Australia. A sample of 28 documents, comprising 1,394 pages, is analysed in the context of the 2012-2013 Victorian Inquiry into the Handling of Child Abuse by Religious and Other Organisations. Sykes and Matza’s (1957 and Cohen’s (1993 techniques of, respectively, neutralisation and denial are used to reveal the Catholic Church’s Janus-faced responses to clergy-child sexual abuse and mandatory reporting requirements. Paradoxical tensions are observed between Catholic Canonical law and clerical practices, and the extent of compliance with secular law and referral of allegations to authorities. Concerns centre on Church secrecy, clerical defences of the confessional in justification of inaction, and the Melbourne Response compensation scheme. Our research findings underscore the need for greater Church transparency and accountability; we advocate for mandatory reporting law reform and institutional reform, including adjustments to the confessional ritual.

  20. Observed infant food cue responsivity: Associations with maternal report of infant eating behavior, breastfeeding, and infant weight gain.

    Science.gov (United States)

    Buvinger, Elizabeth; Rosenblum, Katherine; Miller, Alison L; Kaciroti, Niko A; Lumeng, Julie C

    2017-05-01

    Infant obesity and the rate of weight gain during infancy are significant public health concerns, but few studies have examined eating behaviors in infancy. Food cue responsivity has been described as a key contributor to obesity risk in school age children and adults, but has been rarely examined during infancy. The purpose of the current study was to test among 30 infants aged 6-12 months the hypotheses that infants would show greater interest in food versus non-food stimuli, and that greater birth weight, greater rate of weight gain during infancy, greater mother-reported food responsiveness, being formula versus breastmilk fed, and higher maternal body mass index, would each be associated with greater interest in the food versus non-food stimulus. Results showed that overall infants showed a preference for the food versus non-food stimulus. Preference for the food versus non-food stimulus was predicted by greater infant rate of weight gain since birth, greater maternal-reported infant food responsiveness, and having been exclusively formula-fed, but not by any other factor tested. Results are discussed with regard to theoretical implications for the study of infant obesity and applied prevention implications. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Grassland/atmosphere response to changing climate: Coupling regional and local scales. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Coughenour, M.B.; Kittel, T.G.F.; Pielke, R.A.; Eastman, J.

    1993-10-01

    The objectives of the study were: to evaluate the response of grassland ecosystems to atmospheric change at regional and site scales, and to develop multiscaled modeling systems to relate ecological and atmospheric models with different spatial and temporal resolutions. A menu-driven shell was developed to facilitate use of models at different temporal scales and to facilitate exchange information between models at different temporal scales. A detailed ecosystem model predicted that C{sub 3} temperate grasslands wig respond more strongly to elevated CO{sub 2} than temperate C{sub 4} grasslands in the short-term while a large positive N-PP response was predicted for a C{sub 4} Kenyan grassland. Long-term climate change scenarios produced either decreases or increases in Colorado plant productivity (NPP) depending on rainfall, but uniform increases in N-PP were predicted in Kenya. Elevated CO{sub 2} is likely to have little effect on ecosystem carbon storage in Colorado while it will increase carbon storage in Kenya. A synoptic climate classification processor (SCP) was developed to evaluate results of GCM climate sensitivity experiments. Roughly 80% agreement was achieved with manual classifications. Comparison of lx and 2xCO{sub 2} GCM Simulations revealed relatively small differences.

  2. Effects of vitamin nutrition on the immune response of hatchery-reared salmonids. Annual report, 1984

    International Nuclear Information System (INIS)

    Leith, D.; Holmes, J.; Kaattari, S.; Yui, M.; Jones, T.

    1985-09-01

    Results demonstrate that immunological assays. Lymphocytes from both of the major lymphoid organs (spleen and anterior kidney) produce significant in vitro antibody responses to the antigen, trinitrophenyl-lipopolysaccharide. These cells also demonstrate significant mitogenic stimulation (proliferation) in response to bacterial lipopolysaccharide, phytohemagglutinin, and to a novel mitogen, Vibrio anguillarum extract. As an assessment of cell-mediated immunity, we have found that lymphocytes are capable of responding in a mixed lymphocyte reaction as demonstrated by increased incorporation of tritiated thymidine. Results also indicate that phagocytosis can be quantified by the uptake of radioiodinated Renibacterium salmoninarum and that production of migration inhibition factor (MIF)-like activity can be induced in immunized animals. Polyclonal activation of chinook lymphocytes was elicited by both Vibrio anguillarum extract and E. coli lipopolysaccharide. Groups of spring chinook salmon were fed a formula diet containing five dietary levels of pyridoxine (15, 30, 60, 120, and 1500 mg/kg diet). Data collected on growth and feed efficiency in the first eighteen weeks show no significant difference between these formulations. 46 refs., 20 figs., 7 tabs

  3. Bridging the Divide: Linking Genomics to Ecosystem Responses to Climate Change: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Melinda D.

    2014-03-15

    Over the project period, we have addressed the following objectives: 1) assess the effects of altered precipitation patterns (i.e., increased variability in growing season precipitation) on genetic diversity of the dominant C4 grass species, Andropogon gerardii, and 2) experimentally assess the impacts of extreme climatic events (heat wave, drought) on responses of the dominant C4 grasses, A. gerardii and Sorghastrum nutans, and the consequences of these response for community and ecosystem structure and function. Below is a summary of how we have addressed these objectives. Objective 1 After ten years of altered precipitation, we found the number of genotypes of A. gerardii was significantly reduced compared to the ambient precipitation treatments (Avolio et al., 2013a). Although genotype number was reduced, the remaining genotypes were less related to one another indicating that the altered precipitation treatment was selecting for increasingly dissimilar genomes (based on mean pairwise Dice distance among individuals). For the four key genotypes that displayed differential abundances depending on the precipitation treatment (G1, G4, and G11 in the altered plots and G2 in the ambient plots), we identified phenotypic differences in the field that could account for ecological sorting (Avolio & Smith, 2013a). The three altered rainfall genotypes also have very different phenotypic traits in the greenhouse in response to different soil moisture availabilities (Avolio and Smith, 2013c). Two of the genotypes that increased in abundance in the altered precipitation plots had greater allocation to root biomass (G4 and G11), while G1 allocated more biomass aboveground. These phenotypic differences among genotypes suggests that changes in genotypic structure between the altered and the ambient treatments has likely occurred via niche differentiation, driven by changes in soil moisture dynamics (reduced mean, increased variability and changes in the depth distribution of

  4. Emotionality in response to aircraft noise: A report of development work

    Science.gov (United States)

    Klaus, P. A.

    1975-01-01

    A literature search and pilot study conducted to investigate the topic of emotional response to aircraft noise are described. A Tell-A-Story Technique was developed for use in the pilot study which required respondents to make up stories for a series of aircraft-related and non-aircraft-related pictures. A content analysis of these stories was made. The major finding was that response patterns varied among three groups of respondents - those currently living near airports, those who had lived near airports in the past, and those who had never lived near airports. Negative emotional feelings toward aircraft were greatest among respondents who had lived near airports in the past but no longer did. A possible explanation offered for this finding was that people currently living near airports might adapt to the situation by denying some of their negative feelings, which they might feel more free to express after they had moved away from the situation. Other techniques used in the pilot study are also described, including group interviews and a word association task.

  5. A report on upgraded seismic monitoring stations in Myanmar: Station performance and site response

    Science.gov (United States)

    Thiam, Hrin Nei; Min Htwe, Yin Myo; Kyaw, Tun Lin; Tun, Pa Pa; Min, Zaw; Htwe, Sun Hninn; Aung, Tin Myo; Lin, Kyaw Kyaw; Aung, Myat Min; De Cristofaro, Jason; Franke, Mathias; Radman, Stefan; Lepiten, Elouie; Wolin, Emily; Hough, Susan E.

    2017-01-01

    Myanmar is in a tectonically complex region between the eastern edge of the Himalayan collision zone and the northern end of the Sunda megathrust. Until recently, earthquake monitoring and research efforts have been hampered by a lack of modern instrumentation and communication infrastructure. In January 2016, a major upgrade of the Myanmar National Seismic Network (MNSN; network code MM) was undertaken to improve earthquake monitoring capability. We installed five permanent broadband and strong‐motion seismic stations and real‐time data telemetry using newly improved cellular networks. Data are telemetered to the MNSN hub in Nay Pyi Taw and archived at the Incorporated Research Institutions for Seismology Data Management Center. We analyzed station noise characteristics and site response using noise and events recorded over the first six months of station operation. Background noise characteristics vary across the array, but indicate that the new stations are performing well. MM stations recorded more than 20 earthquakes of M≥4.5 within Myanmar and its immediate surroundings, including an M 6.8 earthquake located northwest of Mandalay on 13 April 2016 and the Mw 6.8 Chauk event on 24 August 2016. We use this new dataset to calculate horizontal‐to‐vertical spectral ratios, which provide a preliminary characterization of site response of the upgraded MM stations.

  6. Site-specific earthquake response analysis for Paducah Gaseous Diffusion Plant, Paducah, Kentucky. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Sykora, D.W.; Davis, J.J.

    1993-08-01

    The Paducah Gaseous Diffusion Plant (PGDP), owned by the US Department of Energy (DOE) and operated under contract by Martin Marietta Energy systems, Inc., is located southwest of Paducah, Kentucky. An aerial photograph and an oblique sketch of the plant are shown in Figures 1 and 2, respectively. The fenced portion of the plant consists of 748 acres. This plant was constructed in the 1950`s and is one of only two gaseous diffusion plants in operation in the United States; the other is located near Portsmouth, Ohio. The facilities at PGDP are currently being evaluated for safety in response to natural seismic hazards. Design and evaluation guidelines to evaluate the effects of earthquakes and other natural hazards on DOE facilities follow probabilistic hazard models that have been outlined by Kennedy et al. (1990). Criteria also established by Kennedy et al. (1990) classify diffusion plants as ``moderate hazard`` facilities. The US Army Engineer Waterways Experiment Station (WES) was tasked to calculate the site response using site-specific design earthquake records developed by others and the results of previous geotechnical investigations. In all, six earthquake records at three hazard levels and four individual and one average soil columns were used.

  7. Final Scientific Technical Report: INTEGRATED PREDICTIVE DEMAND RESPONSE CONTROLLER FOR COMMERCIAL BUILDINGS

    Energy Technology Data Exchange (ETDEWEB)

    Wenzel, Mike

    2013-10-14

    This project provides algorithms to perform demand response using the thermal mass of a building. Using the thermal mass of the building is an attractive method for performing demand response because there is no need for capital expenditure. The algorithms rely on the thermal capacitance inherent in the building?s construction materials. A near-optimal ?day ahead? predictive approach is developed that is meant to keep the building?s electrical demand constant during the high cost periods. This type of approach is appropriate for both time-of-use and critical peak pricing utility rate structures. The approach uses the past days data in order to determine the best temperature setpoints for the building during the high price periods on the next day. A second ?model predictive approach? (MPC) uses a thermal model of the building to determine the best temperature for the next sample period. The approach uses constant feedback from the building and is capable of appropriately handling real time pricing. Both approaches are capable of using weather forecasts to improve performance.

  8. Clinical responsiveness of self-report functional assessment measures for children with juvenile idiopathic arthritis undergoing intraarticular corticosteroid injections.

    Science.gov (United States)

    Brown, G Ted; Wright, F Virginia; Lang, Bianca A; Birdi, Nina; Oen, Kim; Stephens, Derek; McComas, Joan; Feldman, Brian M

    2005-12-15

    The Childhood Health Assessment Questionnaire (CHAQ), Juvenile Arthritis Functional Assessment Report (JAFAR), and Juvenile Arthritis Functional Status Index (JASI) are widely used functional measures for juvenile idiopathic arthritis (JIA) that differ in content, format, and completion time. We compared the responsiveness and child-parent agreement of the JAFAR, CHAQ, and JASI in a prospective, multicenter study. Children and adolescents from 5 rheumatology centers were enrolled. Subjects were about to undergo therapy (intraarticular corticosteroid injections [IAS] and methotrexate or hip surgery (MTX/hip]) expected to produce a functional improvement. All subjects were studied before the intervention and at 6 weeks and 6 months posttreatment. At each study visit, the 3 measures were administered in randomized, balanced order to both parents and children. A total of 92 subjects (mean age 12.8 years) were enrolled in the study, 74 of which were in the IAS group. The responsiveness of all 3 measures was moderate to strong. The standardized response mean at 6 weeks for the IAS group on the JAFAR, CHAQ, and JASI was 0.41 (95% confidence interval [95% CI] 0.18, 0.64), 0.70 (95% CI 0.47, 0.93), and 0.36 (95% CI 0.13, 0.59), respectively. The CHAQ was somewhat more responsive to change at 6 weeks (IAS group: relative efficiency 0.34 [JAFAR], 0.27 [JASI]), but less responsive at 6 months (MTX/hip group: relative efficiency 5.1 [JAFAR], 3.9 [JASI]). All 3 questionnaires showed acceptable parent-child agreement, and overall, there were few differences between the 3 questionnaires. The functional outcome measures currently used for JIA are all adequately responsive for use in trials or in the clinic setting. The choice of which measure to use should therefore be based on the time available for completion, the intended clinical/research use, and the depth of content required.

  9. Are self-report scales as effective as clinician rating scales in measuring treatment response in routine clinical practice?

    Science.gov (United States)

    Zimmerman, Mark; Walsh, Emily; Friedman, Michael; Boerescu, Daniela A; Attiullah, Naureen

    2018-01-01

    Recent treatment guidelines have suggested that outcome should be measured in routine clinical practice. In the present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project, we compared three self-report scales of depressive symptoms and the two most widely used clinician administered scales in treatment studies in their sensitivity to change and evaluation of treatment response in depressed patients treated in routine practice. At baseline and 4-month follow-up 153 depressed outpatients with DSM-IV MDD completed the Clinically Useful Depression Outcome Scale (CUDOS), Quick Inventory of Depressive Symptomatology-Self-report version (QIDS-SR), and Patient Health Questionnaire (PHQ-9). The patients were rated on the 17-item Hamilton Depression Rating Scale (HAMD) and the Montgomery-Asberg Depression Rating Scale (MADRS). On each scale treatment response was defined as a 50% or greater reduction in scores from baseline. While there were some differences in the percentage of patients considered to be responders on the different scales, a large effect size was found for each scale, with little variability amongst the scales. The level of agreement between the three self-report scales and the clinician rating scales was approximately the same LIMITATIONS: The present study was conducted in a single clinical practice in which the majority of the patients were white, female, and had health insurance. When measuring outcome in clinical practice the magnitude of change in depressive symptoms is as great on self-report scales as on clinician rating scales. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Self-reported impulsivity, but not behavioral choice or response impulsivity, partially mediates the effect of stress on drinking behavior.

    Science.gov (United States)

    Hamilton, Kristen R; Ansell, Emily B; Reynolds, Brady; Potenza, Marc N; Sinha, Rajita

    2013-01-01

    Stress and impulsivity contribute to alcohol use, and stress may also act via impulsivity to increase drinking behavior. Impulsivity represents a multi-faceted construct and self-report and behavioral assessments may effectively capture distinct clinically relevant factors. The present research investigated whether aspects of impulsivity mediate the effect of stress on alcohol use. A community-based sample of 192 men and women was assessed on measures of cumulative stress, alcohol use, self-reported impulsivity, and behavioral choice and response impulsivity. Data were analyzed using regression and bootstrapping techniques to estimate indirect effects of stress on drinking via impulsivity. Cumulative adversity exhibited both direct effects and indirect effects (via self-reported impulsivity) on drinking behavior. Additional models examining specific types of stress indicated direct and indirect effects of trauma and recent life events, and indirect effects of major life events and chronic stressors on drinking behavior. Overall, cumulative stress was associated with increased drinking behavior, and this effect was partially mediated by self-reported impulsivity. Self-reported impulsivity also mediated the effects of different types of stress on drinking behavior. These findings highlight the value of mediation models to examine the pathways through which different types of stress increase drinking behavior. Treatment and prevention strategies should focus on enhancing stress management and self-control.

  11. Proton pump inhibitor-responsive chronic cough without acid reflux: a case report

    Directory of Open Access Journals (Sweden)

    Nobata Kouichi

    2007-08-01

    Full Text Available Abstract Background Because 24-h esophageal pH monitoring is quite invasive, the diagnosis of gastroesophageal reflux disease (GERD-associated cough has usually been made based merely on the clinical efficacy of treatment with proton pump inhibitor (PPI. Case presentation We recently encountered two patients with PPI-responsive chronic non-productive cough for whom switching from bronchodilators and glucocorticosteroids to PPI resulted in improvement of cough. The cough returned nearly to pre-administration level a few weeks after discontinuation of PPI. Though GERD-associated cough was suspected, 24-h esophageal pH monitoring revealed that the cough rarely involved gastric acid reflux. Following re-initiation of PPI, the cough disappeared again. Conclusion PPI may improve cough unrelated to gastric acid reflux.

  12. Enhancing Police Responses to Domestic Violence Incidents: Reports From Client Advocates in New South Wales.

    Science.gov (United States)

    Goodman-Delahunty, Jane; Crehan, Anna Corbo

    2016-07-01

    In an online survey about experiences with the police complaint system, 239 client advocates described a recent incident in which a client with grounds to lodge a complaint declined to do so. Almost one third of those incidents involved domestic violence. Thematic analysis of case descriptions revealed that many police did not take domestic violence reports seriously. A typology of problematic police conduct was developed. Many officers failed to observe current procedures and appeared to lack knowledge of relevant laws. Citizens feared retaliatory victimization by police and/or perceived that complaining was futile. Implications of these findings are reviewed in light of procedural justice theory. © The Author(s) 2015.

  13. Power Transfer Potential to the Southeast in Response to a Renewable Portfolio Standard: Interim Report 2

    Energy Technology Data Exchange (ETDEWEB)

    Hadley, Stanton W [ORNL; Key, Thomas S [Electric Power Research Institute (EPRI); Deb, Rajat [LCG Consulting

    2009-05-01

    Electricity consumption in the Southeastern US, not including Florida, is approximately 24% of the total US. The availability of renewable resources for electricity production is relatively small compared to the high consumption. Therefore meeting a national renewable portfolio standard (RPS) is particularly challenging in this region. Neighboring regions, particularly to the west, have significant wind resources and given sufficient long distant transmission these resources could serve energy markets in the SE. This report looks at renewable resource supply relative to demands and the potential for power transfer into the SE. It shows that development of wind resources will depend not only on available transmission capacity but also on electricity supply and demand factors.

  14. Treatment with Ipilimumab: A Case Report of Complete Response in a Metastatic Malignant Melanoma Patient

    Directory of Open Access Journals (Sweden)

    Alfredo Addeo

    2013-05-01

    Full Text Available Introduction: Over the past year, 3 agents have been approved for the treatment of melanoma by the Food and Drug Administration. These include pegylated interferon α-2b for stage III melanoma, vemurafenib for unresectable or metastatic melanoma with BRAF V600E mutation, and ipilimumab for unresectable or metastatic melanoma. Case Presentation: We present here the case of a 65-year-old Caucasian male diagnosed with advanced melanoma in April 2011 and treated with ipilimumab (Yervoy®, a monoclonal antibody targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4, as second-line treatment after progression with dacarbazine, for (wild-type BRAF metastatic melanoma. The patient was referred to us for several painful lumps on his right arm. A biopsy of one of them revealed melanoma. CT and PET scans did not show any other lesions or a primary site. The patient was started on first-line chemotherapy with dacarbazine 850 mg/m2 on day 1, every 3 weeks. After 3 cycles, the patient showed disease progression with an increase in size of the skin metastasis. Second-line treatment was started with ipilimumab 3 mg/kg on day 1, every 3 weeks. At the end of the treatment, after 4 cycles, we documented a complete clinical response with total resolution of the skin metastasis. At the time of writing this paper, our patient had finished his treatment more than 9 months earlier and is still in complete remission. Conclusion: This is a paradigmatic case where, despite extensive metastatic disease, treatment with ipilimumab has confirmed its efficacy. It is still an open question why only a minority of patients have such a remarkable response, and further trials are warranted to address this important question.

  15. Creating a web-enhanced interactive preclinic technique manual: case report and student response.

    Science.gov (United States)

    Boberick, Kenneth G

    2004-12-01

    This article describes the development, use, and student response to an online manual developed with off-the-shelf software and made available using a web-based course management system (Blackboard) that was used to transform a freshman restorative preclinical technique course from a lecture-only course into an interactive web-enhanced course. The goals of the project were to develop and implement a web-enhanced interactive learning experience in a preclinical restorative technique course and shift preclinical education from a teacher-centered experience to a student-driven experience. The project was evaluated using an anonymous post-course survey (95 percent response rate) of 123 freshman students that assessed enabling (technical support and access to the technology), process (the actual experience and usability), and outcome criteria (acquisition and successful use of the knowledge gained and skills learned) of the online manual. Students responded favorably to sections called "slide galleries" where ideal and non-ideal examples of projects could be viewed. Causes, solutions, and preventive measures were provided for the errors shown. Sections called "slide series" provided cookbook directions allowing for self-paced and student-directed learning. Virtually all of the students, 99 percent, found the quality of the streaming videos adequate to excellent. Regarding Internet connections and video viewing, 65 percent of students successfully viewed the videos from a remote site; cable connections were the most reliable, dial-up connections were inadequate, and DSL connections were variable. Seventy-three percent of the students felt the videos were an effective substitute for in-class demonstrations. Students preferred video with sound over video with subtitles and preferred short video clips embedded in the text over compilation videos. The results showed it is possible to develop and implement web-enhanced and interactive dental education in a preclinical

  16. Sharing our energies. Corporate social responsibility report 2005; Notre energie en partage. Rapport societal et environnemental 2005

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-05-15

    Total is a multinational energy company, the fourth largest publicly-traded integrated oil and gas company in the world. Total worldwide operations are conducted through three business segments: Upstream includes oil and gas Exploration and Production, Gas and Power and other energy sources. Downstream covers Trading and Shipping,Refining and the Marketing of TOTAL and Elf brand petroleum products, automotive and other fuels, and specialties such as LPG, aviation fuel and lubricants, through both the retail network and other outlets worldwide. Chemicals comprises various activities including Base chemicals (Petrochemicals and Fertilizers) and Specialties for industry and the consumer market. This corporate social responsibility report presents the Group activity for the year 2005 in the following domains: the business principles, the environment safety and health, the social responsibility and the local development, the future of energy (fossil fuels, renewable energies and towards energy vectors). (A.L.B.)

  17. Modified Exposure and Response Prevention to Treat the Repetitive Behaviors of a Child with Autism: A Case Report

    Directory of Open Access Journals (Sweden)

    Brian A. Boyd

    2011-01-01

    Full Text Available We report the case study of a school-aged child with autism whose repetitive behaviors were treated with a modified version of a technique routinely used in cognitive behavior therapy (i.e., exposure response prevention to treat obsessive-compulsive disorder. A trained behavioral therapist administered the modified ERP treatment over the course of an intensive two-week treatment period with two therapy sessions occurring daily. The treatment was successful at decreasing the amount of child distress and cooccurring problem behavior displayed; however, the child's interest in the repetitive behavior eliciting stimulus (i.e., puzzles remained. The case study demonstrates specific ways that exposure response prevention strategies can be adapted to the unique kinds of repetitive behaviors that present clinically in autism. A larger clinical trial is needed to substantiate these findings.

  18. Do we need social reports? New challenge for corporate social responsibility

    Directory of Open Access Journals (Sweden)

    Jarosławska-Sobór Sylwia

    2017-12-01

    Full Text Available Directive 2014/95/EU of the European Parliament and the Council entered into force on 1 January 2017, regards disclosure of non-financial and diversity information by certain large undertakings and groups. Its aim is to enhance the consistency and comparability of non-financial information disclosed throughout the Union. Large public-interest entities will be obligated to prepare a non-financial statement containing information relating to at least environmental matters, social and employee-related matters, respect for human rights, anti-corruption and bribery matters. What it means in practice ? Whether we need a social reports ? In this paper different aspects of new directives, it’s theoretical basement and functional range has been discussed. Opportunities and vulnerabilities, which directives sets on the path forward on CSR will be provided. On the case of designated Integrated Annual Report will be pointed elements, which can provides stakeholders with market information and infulence on an image of the company.

  19. Medically unexplained symptom reports are associated with a decreased response to the rubber hand illusion.

    Science.gov (United States)

    Miles, Eleanor; Poliakoff, Ellen; Brown, Richard J

    2011-10-01

    Medically unexplained symptoms (MUS) have been hypothesized to result from a distortion in perception, whereby top-down factors influence the process of body representation. Perceptual illusions provide a novel method of investigating this hypothesis. This study aimed to investigate whether self-reported unexplained symptoms are associated with altered experience of the rubber hand illusion (RHI). A non-clinical MUS group with high scores on the Somatoform Dissociation Questionnaire (SDQ), and a control group with low scores on this scale, were exposed to the RHI. Illusion experience was measured by self-reports and by proprioceptive alteration. After controlling for somatosensory amplification and trait anxiety, the low-SDQ group responded significantly more strongly to the RHI on both questionnaire and proprioceptive measures of the illusion. In contrast, the high-SDQ group scored significantly higher on the Perceptual Aberrations Scale, a measure of bodily distortions in daily life. These findings support the proposed link between MUS and disturbances in body representation, and suggest that a decreased reliance on current sensory inputs may contribute to symptom experience in susceptible individuals. Copyright © 2011 Elsevier Inc. All rights reserved.

  20. Joint research and development and exchange of technology on toxic material emergency response between LLNL and ENEA. 1985 progress report

    International Nuclear Information System (INIS)

    Dickerson, M.H.; Caracciolo, R.

    1986-01-01

    For the past six years, the US Department of Energy, LLNL, and the ENEA, Rome, Italy, have participated in cooperative studies for improving a systems approach to an emergency response following nuclear accidents. Technology exchange between LLNL and the ENEA was initially confined to the development, application, and evaluation of atmospheric transport and diffusion models. With the emergence of compatible hardware configurations between LLNL and ENEA, exchanges of technology and ideas for improving the development and implementation of systems are beginning to emerge. This report describes cooperative work that has occurred during the past three years, the present state of each system, and recommendations for future exchanges of technology

  1. Work-related injuries and illnesses reported by World Trade Center response workers and volunteers.

    Science.gov (United States)

    Perritt, Kara R; Herbert, Robin; Levin, Stephen M; Moline, Jacqueline

    2011-12-01

    In 2002, the Mount Sinai Center for Occupational and Environmental Medicine, with support from the National Institute for Occupational Safety and Health (NIOSH), began coordinating the World Trade Center (WTC) Worker and Volunteer Medical Screening Program (MSP) to monitor the health of qualified WTC responders. Enrolled participants were offered a clinical examination; interviewed to collect medical, mental health, and exposure information; and requested to complete a self-administered medical questionnaire. The objective of this study was to better understand work-related injuries and illnesses sustained on-site by WTC responders. A descriptive analysis of select data from the MSP self-administered medical questionnaire was conducted. Data collected July 2002 through April 2004 from MSP participants enrolled at the Mount Sinai clinic were reviewed using univariate statistical techniques. Records from 7,810 participants were analyzed, with most participants associated with either the construction industry (n = 2,623, 34%) or law enforcement (n = 2,036, 26%). Approximately a third of the participants (n = 2,486, 32%) reported at least one injury or illness requiring medical treatment that was sustained during WTC work/volunteer activities. Of the total 4,768 injuries/illnesses reported by these participants, respiratory complaints were most common (n = 1,350, 28%), followed by traumatic injuries excluding eye injuries (n = 961, 20%), eye injuries/ailments (n = 709, 15%), chest pain (n = 375, 8%), headaches (n = 359, 8%), skin conditions (n = 178, 4%), and digestive system conditions (n = 163, 3%). Participants reported that 36% of injuries/illnesses were treated off-site and 29% were treated on-site, with the remaining not specifying treatment location. Off-site treatment was prevalent for respiratory complaints, psychological stress, and chest pain. On-site treatment was predominate for eye injuries/ailments and traumatic injuries excluding eye injuries. Study

  2. Aromatic Amino Acid Decarboxylase Deficiency Not Responding to Pyridoxine and Bromocriptine Therapy: Case Report and Review of Response to Treatment

    Directory of Open Access Journals (Sweden)

    Majid Alfadhel

    2014-01-01

    Full Text Available Aromatic L-amino acid decarboxylase (AADC deficiency (MIM #608643 is an autosomal recessive inborn error of monoamines. It is caused by a mutation in the DDC gene that leads to a deficiency in the AADC enzyme. The clinical features of this condition include a combination of dopamine, noradrenaline, and serotonin deficiencies, and a patient may present with hypotonia, oculogyric crises, sweating, hypersalivation, autonomic dysfunction, and progressive encephalopathy with severe developmental delay. We report the case of an 8-month-old boy who presented with the abovementioned symptoms and who was diagnosed with AADC deficiency based on clinical, biochemical, and molecular investigations. Treatment with bromocriptine and pyridoxine showed no improvement. These data support the findings observed among previously reported cohorts that showed poor response of this disease to current regimens. Alternative therapies are needed to ameliorate the clinical complications associated with this disorder.

  3. [Effects of musical emotionality upon GSR and respiration rate: the relationship between verbal reports and physiological responses].

    Science.gov (United States)

    Nakamura, H

    1984-04-01

    The purpose of this study was to determine the relationship between verbally reported emotional meanings of music and physiological responses to them. Subjects were 16 female, junior college students in each of GSR and respiration experiments. They listened to 16 musical excerpts and rated each on 11 scales, which consisted of eight adjectives representing for four factors identified by factor analysis and each for familiarity, preference and tempo, while their GSRs or respiration rates were recorded. The respiration rates and their percentages of increase significantly correlated positively with ratings of "cheerful", "gay" and "powerful", and negatively with "calm", "melancholy" and "dismal". The numbers of GSRs (frequencies of marked GSRs) and the percentages of decrease in skin resistance significantly correlated negatively with "calm", and positively with "powerful". The physiological variables employed in this study correlated with the verbal reports of meanings of music.

  4. A review of sex differences in sexual jealousy, including self-report data, psychophysiological responses, interpersonal violence, and morbid jealousy.

    Science.gov (United States)

    Harris, Christine R

    2003-01-01

    The specific innate modular theory of jealousy hypothesizes that natural selection shaped sexual jealousy as a mechanism to prevent cuckoldry, and emotional jealousy as a mechanism to prevent resource loss. Therefore, men should be primarily jealous over a mate's sexual infidelity and women over a mate's emotional infidelity. Five lines of evidence have been offered as support: self-report responses, psychophysiological data, domestic violence (including spousal abuse and homicide), and morbid jealousy cases. This article reviews each line of evidence and finds only one hypothetical measure consistent with the hypothesis. This, however, is contradicted by a variety of other measures (including reported reactions to real infidelity). A meta-analysis of jealousy-inspired homicides, taking into account base rates for murder, found no evidence that jealousy disproportionately motivates men to kill. The findings are discussed from a social-cognitive theoretical perspective.

  5. Professional regulation. Part 7b: CHRE report and the NMC response.

    Science.gov (United States)

    Fullbrook, Suzanne

    The previous article in the series explored political and procedural mechanisms that have a direct bearing on the ability of the Nursing and Midwifery Council (NMC) to undertake its statutory functions. The issue of a recent debate in the House of Commons was mentioned, with a view to discussing the nature of that enquiry in this article. This article reviews a recent report by the Centre for Healthcare Regulatory Excellence into the internal affairs of the NMC, to identify the reasons why the personal behaviours of a small group of individuals the council members of the NMC and the staff of the organization should impact on the way in which the Government and the public view all nurses.

  6. Durable response using regorafenib in an elderly patient with metastatic colorectal cancer: case report

    Directory of Open Access Journals (Sweden)

    Tang R

    2015-11-01

    Full Text Available Ronald Tang,1 Tatiana Kain,2 June Herman,2 Tara Seery1 1Division of Hematology-Oncology, 2Division of Nuclear Medicine and Molecular Imaging, University of California, Irvine, Orange, CA, USA Abstract: Regorafenib, an oral multikinase inhibitor, was approved in September 2012 by the US Food and Drug Administration for the treatment of patients with metastatic colorectal cancer. Since this time, however, few case reports outlining real-world usage have been published in the literature. Here, we detail the clinical history of an elderly woman with KRAS wild-type colon cancer who received regorafenib after prior treatment with other agents. We show that by employing dose modification strategies to address adverse events, this patient was able to remain on therapy for 11 months and achieve stable disease. Keywords: regorafenib, metastatic colorectal cancer, oral multikinase inhibitor

  7. Power Transfer Potential to the Southeast in Response to a Renewable Portfolio Standard: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Key, Thomas S [Electric Power Research Institute (EPRI); Hadley, Stanton W [ORNL; Deb, Rajat [LCG Consulting

    2010-02-01

    Electricity consumption in the Southeastern US, including Florida, is approximately 32% of the total US. The availability of renewable resources for electricity production is relatively small compared to the high consumption. Therefore meeting a national renewable portfolio standard (RPS) is particularly challenging in this region. Neighboring regions, particularly to the west, have significant wind resources and given sufficient transmission these resources could serve energy markets in the SE. This report looks at renewable resource supply relative to demands and the potential for power transfer into the SE. We found that significant wind energy transfers, at the level of 30-60 GW, are expected to be economic in case of federal RPC or CO2 policy. Development of wind resources will depend not only on the available transmission capacity and required balancing resources, but also on electricity supply and demand factors.

  8. Is Earth recognized as a finite system in corporate responsibility reporting?

    DEFF Research Database (Denmark)

    Bjørn, Anders; Bey, Niki; Georg, Susse

    2017-01-01

    as to why some companies abandoned planned changes altogether.Our findings provide novel insights into the current use of the ecological limits concept by companies and may be useful for actors trying to motivate companies to align their activities with the finite nature of Earth's natural systems....... limits were related to climate change and references to "2°C" were by far the most frequent. The vast majority of companies referring to ecological limits did so without specific references to ongoing or planned changes in their activities as a consequence of recognizing these limits. Only a small...... dealt explicitly with the issue of allocating resource and emission rights within ecological limits amongst companies and other actors. A longitudinal study of three companies showed that these did not directly report progress towards planned changes based on ecological limits and offered explanations...

  9. Evaluating Cumulative Ecosystem Response to Restoration Projects in the Columbia River Estuary, Annual Report 2005

    Energy Technology Data Exchange (ETDEWEB)

    Diefenderfer, Heida L.; Thom, Ronald M.; Borde, Amy B.; Roegner, G. C.; Whiting, Allan H.; Johnson, Gary E.; Dawley, Earl; Skalski, John R.; Vavrinec, John; Ebberts, Blaine D.

    2006-12-20

    This report is the second annual report of a six-year project to evaluate the cumulative effects of habitat restoration projects in the Columbia River Estuary, conducted by Pacific Northwest National Laboratory's Marine Sciences Laboratory, NOAA's National Marine Fisheries Service Pt. Adams Biological Field Station, and the Columbia River Estuary Study Taskforce for the US Army Corps of Engineers. In 2005, baseline data were collected on two restoration sites and two associated reference sites in the Columbia River estuary. The sites represent two habitat types of the estuary--brackish marsh and freshwater swamp--that have sustained substantial losses in area and that may play important roles for salmonids. Baseline data collected included vegetation and elevation surveys, above and below-ground biomass, water depth and temperature, nutrient flux, fish species composition, and channel geometry. Following baseline data collection, three kinds of restoration actions for hydrological reconnection were implemented in several locations on the sites: tidegate replacements (2) at Vera Slough, near the city of Astoria in Oregon State, and culvert replacements (2) and dike breaches (3) at Kandoll Farm in the Grays River watershed in Washington State. Limited post-restoration data were collected: photo points, nutrient flux, water depth and temperature, and channel cross-sections. In subsequent work, this and additional post-restoration data will be used in conjunction with data from other sites to estimate net effects of hydrological reconnection restoration projects throughout the estuary. This project is establishing methods for evaluating the effectiveness of individual projects and a framework for assessing estuary-wide cumulative effects including a protocol manual for monitoring restoration and reference sites.

  10. Measurement equivalence of the KINDL questionnaire across child self-reports and parent proxy-reports: a comparison between item response theory and ordinal logistic regression.

    Science.gov (United States)

    Jafari, Peyman; Sharafi, Zahra; Bagheri, Zahra; Shalileh, Sara

    2014-06-01

    Measurement equivalence is a necessary assumption for meaningful comparison of pediatric quality of life rated by children and parents. In this study, differential item functioning (DIF) analysis is used to examine whether children and their parents respond consistently to the items in the KINDer Lebensqualitätsfragebogen (KINDL; in German, Children Quality of Life Questionnaire). Two DIF detection methods, graded response model (GRM) and ordinal logistic regression (OLR), were applied for comparability. The KINDL was completed by 1,086 school children and 1,061 of their parents. While the GRM revealed that 12 out of the 24 items were flagged with DIF, the OLR identified 14 out of the 24 items with DIF. Seven items with DIF and five items without DIF were common across the two methods, yielding a total agreement rate of 50 %. This study revealed that parent proxy-reports cannot be used as a substitute for a child's ratings in the KINDL.

  11. Response report from US Department of Energy hearings on proposed salt site nominations

    International Nuclear Information System (INIS)

    1983-11-01

    As required by the Nuclear Waste Policy Act (US Congress, 1983, Pub. L. 97-425, Section 112(b)(2)), the US Department of Energy (DOE) conducted a series of nine formal public hearings during April and May 1983, in Louisiana, Mississippi, Texas, and Utah and in the state capitals of Mississippi, Texas, and Utah. The hearings were held in local communities in the vicinity of sites identified as potentially suitable for further study in the program to select a site for the nation's first repository for high-level nuclear waste. The public hearings for potential sites in salt focused on the proposed nomination of the Vacherie salt dome site in Louisiana; the Richton and Cypress Creek salt dome sites in Mississippi; the Deaf Smith County and Swisher County bedded salt sites in Texas; and the Davis and Lavender Canyon bedded salt sites in Utah. The oral and written comments made during the course of the nine formal public hearings were analyzed, paraphrased into almost 1100 comments, and grouped into 62 issues or subjects within the following nine major topical areas: National Waste Terminal Storage program Planning Process, Consultation and Cooperation, Engineering/Repository Design, Geology, Hydrology, Transportation, Public Health and Safety, Environmental Quality, and Socioeconomics. This document provides general responses to each of the 62 major issues raised during the hearings

  12. Response report from US Department of Energy Hearings on proposed salt site nominations

    International Nuclear Information System (INIS)

    1983-11-01

    As required by the Nuclear Waste Policy Act (US Congress, 1983, Pub. L. 97-425, Section 112(b) (2)), the US Department of Energy (DOE) conducted a series of nine formal public hearings during April and May 1983, in Louisiana, Mississippi, Texas, and Utah and in the state capitals of Mississippi, Texas, and Utah. The hearings were held in local communities in the vicinity of sites identified as potentially suitable for further study in the program to select a site for the nation's first repository for high-level nuclear waste. The public hearings for potential sites in salt focused on the proposed nomination of the Vacherie salt dome site in Louisiana; the Richton and Cypress Creek salt dome sites in Mississippi; the Deaf Smith County and Swisher County bedded salt sites in Texas; and the Davis and Lavender Canyon bedded salt sites in Utah. The oral and written comments made during the course of the nine formal public hearings were analyzed, paraphrased into almost 1100 comments, and grouped into 62 issues or subjects within the following nine major topical areas: National Waste Terminal Storage Program Planning Process, Consultation and Cooperation, Engineering/Repository Design, Geology, Hydrology, Transportation, Public Health and Safety, Environmental Quality, and Socioeconomics. This document provides general responses to each of the 62 major issues raised during the hearings. 137 references, 7 figures, 12 tables

  13. Corporate Social Responsibility Reporting of two Note-issuing Banks in Hong Kong

    Directory of Open Access Journals (Sweden)

    Freda Hui

    2008-12-01

    Full Text Available The environmental performance and management disclosure of organisations came underincreased scrutiny over the past decade due to several factors, particularly the impactorganisations have on the world’s environment and the rapid change in the world’s climate.These concerns prompted organisations, including financial institutions, to review the level oftheir environmental performance and management disclosures to demonstrate, amongst otherobjectives, their level of social responsibility. Due to the nature of their business, financialinstitutions are not generally seen to contribute directly to the degradation of the environment;however, they do provide the funds for many organisations’ projects which directly affect theenvironment.This paper reviews the environmental performance and management disclosuredevelopments in China specifically by two note-issuing banks in Hong Kong: the Hongkongand Shanghai Banking Corporation (HSBC and the Bank of China (Hong Kong Limited(BOCHK from 2003 to 2006. The review is conducted with reference to the EquatorPrinciples, a voluntary environmental performance framework developed specifically forfinancial institutions. The paper also contributes to the literature on legitimation theory, usinga social constructionalist perspective of legitimation.

  14. Staff supplement to the draft report on human engineering guide to control room evaluation: response to comments, sample checklist, draft systems review guidelines, and evaluation procedures

    International Nuclear Information System (INIS)

    1981-03-01

    This staff supplement to Draft Report NUREG/CR-1580, Human Engineering Guide to Control Room Evaluation, provides staff responses to comments on the draft report and supplemental material not provided in the draft report. The supplemental material includes new draft guidelines for the systems review of nuclear power plant control rooms and sample checklists and corresponding human engineering guidelines

  15. Responsiveness in rheumatoid arthritis. a report from the OMERACT 11 ultrasound workshop.

    Science.gov (United States)

    Iagnocco, Annamaria; Naredo, Esperanza; Wakefield, Richard; Bruyn, George A W; Collado, Paz; Jousse-Joulin, Sandrine; Finzel, Stephanie; Ohrndorf, Sarah; Delle Sedie, Andrea; Backhaus, Marina; Berner-Hammer, Hilde; Gandjbakhch, Frederique; Kaeley, Gurjit; Loeuille, Damien; Moller, Ingrid; Terslev, Lene; Aegerter, Philippe; Aydin, Sibel; Balint, Peter V; Filippucci, Emilio; Mandl, Peter; Pineda, Carlos; Roth, Johannes; Magni-Manzoni, Silvia; Tzaribachev, Niolay; Schmidt, Wolfgang A; Conaghan, Philip G; D'Agostino, Maria-Antonietta

    2014-02-01

    To summarize the work performed by the Outcome Measures in Rheumatology (OMERACT) Ultrasound (US) Task Force on the validity of different US measures in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) presented during the OMERACT 11 Workshop. The Task Force is an international group aiming to iteratively improve the role of US in arthritis clinical trials. Recently a major focus of the group has been the assessment of responsiveness of a person-level US synovitis score in RA: the US Global Synovitis Score (US-GLOSS) combines synovial hypertrophy and power Doppler signal in a composite score detected at joint level. Work has also commenced examining assessment of tenosynovitis in RA and the role of US in JIA. The US-GLOSS was tested in a large RA cohort treated with biologic therapy. It showed early signs of improvement in synovitis starting at Day 7 and increasing to Month 6, and demonstrated sensitivity to change of the proposed grading. Subsequent voting questions concerning the application of the US-GLOSS were endorsed by > 80% of OMERACT delegates. A standardized US scoring system for detecting and grading severity of RA tenosynovitis and tendon damage has been developed, and acceptable reliability data were presented from a series of exercises. A preliminary consensus definition of US synovitis in pediatric arthritis has been developed and requires further testing. At OMERACT 11, consensus was achieved on the application of the US-GLOSS for evaluating synovitis in RA; and work continues on development of RA tenosynovitis scales as well as in JIA synovitis.

  16. Molecular events basic to cellular radiation response. Progress report, October 1, 1978-September 30, 1979

    International Nuclear Information System (INIS)

    Kolodny, G.M.

    1980-01-01

    Research during the past year has been directed at induction of specific protein synthesis in differentiated mammalian cells. The Primer Hypothesis for the regulation of eukaryotic gene expression suggests that RNA transcription is primed by small molecular weight RNA. It predicts that albumin mRNA transcription in a 3T3 fibroblast, which ordinarily does not produce albumin, can be initiated by RNA primer present in liver cells. In experiments this past year, mouse fibroblasts were incubated with mouse liver RNA. These cells did indeed produce albumin which was detected by counterimmunoelectrophoresis. Confluent 3T3 cell cultures were incubated with mouse liver RNA and polylysine in serum free media. Counterimmunoelectrophoresis (CIEP) of the dialyzed and lyophilized media against mouse albumin antisera gave a single precipitin line indicating albumin snthesis by the fibroblasts. The synthesis of this protein immunologicaly similar to albumin required new albumin mRNA transcription since it was not synthesized in the presence of actinomycin, could be found in media which had been incubated with RNA significantly smaller in size than albumin mRNA, and was synthesized in the absence of added poly A containing RNA. These results represent the first reported demonstration that RNA can be taken up from the media by cells in culture, and can induce in those cells the production of a differentiated cell product not ordinarily synthesized by those cells, i.e, a change in the normal transcription pattern in those cells

  17. Molecular events basic to cellular radiation response. Progress report, October 1, 1978-September 30, 1979

    Energy Technology Data Exchange (ETDEWEB)

    Kolodny, G M

    1980-01-01

    Research during the past year has been directed at induction of specific protein synthesis in differentiated mammalian cells. The Primer Hypothesis for the regulation of eukaryotic gene expression suggests that RNA transcription is primed by small molecular weight RNA. It predicts that albumin mRNA transcription in a 3T3 fibroblast, which ordinarily does not produce albumin, can be initiated by RNA primer present in liver cells. In experiments this past year, mouse fibroblasts were incubated with mouse liver RNA. These cells did indeed produce albumin which was detected by counterimmunoelectrophoresis. Confluent 3T3 cell cultures were incubated with mouse liver RNA and polylysine in serum free media. Counterimmunoelectrophoresis (CIEP) of the dialyzed and lyophilized media against mouse albumin antisera gave a single precipitin line indicating albumin snthesis by the fibroblasts. The synthesis of this protein immunologicaly similar to albumin required new albumin mRNA transcription since it was not synthesized in the presence of actinomycin, could be found in media which had been incubated with RNA significantly smaller in size than albumin mRNA, and was synthesized in the absence of added poly A containing RNA. These results represent the first reported demonstration that RNA can be taken up from the media by cells in culture, and can induce in those cells the production of a differentiated cell product not ordinarily synthesized by those cells, i.e, a change in the normal transcription pattern in those cells.

  18. Cluster headache with ptosis responsive to intranasal lidocaine application: a case report

    Directory of Open Access Journals (Sweden)

    Bakbak Berker

    2012-02-01

    Full Text Available Abstract Introduction The application of lidocaine to the nasal mucosal area corresponding to the sphenopalatine fossa has been shown to be effective at extinguishing pain attacks in patients with a cluster headache. In this report, the effectiveness of local administration of lidocaine on cluster headache attacks as a symptomatic treatment of this disorder is discussed. Cases presentation A 22-year-old Turkish man presented with a five-year history of severe, repeated, unilateral periorbital pain and headache, diagnosed as a typical cluster headache. He suffered from rhinorrhea, lacrimation and ptosis during headaches. He had tried several unsuccessful daily medications. We applied a cotton tip with lidocaine hydrochloride into his left nostril for 10 minutes. The ptosis responded to the treatment and the intensity of his headache decreased. Conclusion Intranasal lidocaine is a useful treatment for the acute management of a cluster headache. Intranasal lidocaine blocks the neural transmission of the sphenopalatine ganglion, which contributes to the trigeminal nerve as well as containing both parasympathetic and sympathetic fibers.

  19. 1999 progress report on environment, health and safety, and social responsibility

    International Nuclear Information System (INIS)

    1999-10-01

    Suncor Energy is a growing Canada-based integrated energy company, which in 1998 had total assets of C$4.1 billion, produced an average of 135,800 barrels of oil equivalent per day, and had refined product sales of 87,000 barrels per day. The company, which has over 2,600 employees, has been conducting business in Canada for more than 75 years. Since the last report in 1997 the company has marked a number of achievements. The company clarified and more sharply focused its vision of long term sustainability and adopted that vision as the foundation of its business planning processes; implemented a comprehensive climate change action plan that includes managing its own emissions, developing alternative and renewable energy, using greenhouse gas offset mechanisms and helping to educate and engage the public and its employees; achieved improved efficiencies in the use of energy and helped to pioneer the use of new environmental tools. Suncor management also explored innovative ways to put industrial byproducts to new use; tested and adopted a methodology for conducting full life cycle assessments of the impacts of its projects and business activities; contributed to the development of public policy on climate change and other environmental issues; enhanced its EHS management systems to be consistent with the International Organization for Standardization's 14001 standard. It took steps to increase diversity in the workplace; established the Suncor Energy Foundation to enhance community investment efforts and became an active member of the World Business Council for Sustainable Development

  20. Clinical report: A patient with a late diagnosis of cerebrotendinous xanthomatosis and a response to treatment.

    Science.gov (United States)

    Alhariri, Ahmad; Hamilton, Katherine; Oza, Vikash; Cordoro, Kelly; Sobreira, Nara L; Malloy, Mary; Slavotinek, Anne

    2017-08-01

    Cerebrotendinous xanthomatosis (CTX) is a rare, autosomal recessive, inborn error of bile acid metabolism characterized by diarrhea in infancy, juvenile cataracts in childhood, tendon xanthomas developing in the second to third decades of life, and progressive neurologic dysfunction in adulthood. The condition is caused by mutations in the CYP27A1 gene that result in decreased production of chenodeoxycholic acid (CDCA) and elevated levels of cholestanol and bile alcohols. We present a 36-year-old male of Han ethnicity who developed xanthomas of his Achilles tendons and suffered neurocognitive declines and gait deterioration in his second decade. The diagnosis of CTX was confirmed by marked elevation of the serum cholestanol level. Sequencing of CYP27A1 showed a paternally inherited splice mutation, c.446 + 1G>T, and a maternally inherited nonsense mutation, c.808C>T, predicting p.(Arg270*). Despite the advanced disease in this patient, treatment with CDCA reduced the xanthoma size and improved his cognition and strength, and the patient made significant gains in his ambulation and coordination. We report this case to illustrate the potential benefits of therapy in patients with CTX who have advanced disease at the time of diagnosis. © 2017 Wiley Periodicals, Inc.

  1. Response to imatinib rechallenge in a patient with a recurrent gastrointestinal stromal tumor after adjuvant therapy: a case report

    Directory of Open Access Journals (Sweden)

    Kang Yoon-Koo

    2011-10-01

    Full Text Available Abstract Introduction Adjuvant imatinib improves recurrence-free survival of patients following resection of primary KIT-positive gastrointestinal stromal tumors. However, it is unknown whether patients who previously received adjuvant imatinib therapy will respond to imatinib rechallenge as treatment for recurrent disease. Here we present the first report documenting the benefits of imatinib rechallenge in a patient previously exposed to imatinib during adjuvant treatment. Case presentation A 51-year-old Asian woman with a wedge-resected primary gastric gastrointestinal stromal tumor at high risk of relapse underwent two years of adjuvant treatment with imatinib. Only 10 months after the completion of adjuvant imatinib treatment, a computed tomography scan revealed gastrointestinal stromal tumor recurrence in this patient, with multiple peritoneal nodules in the upper abdomen being detected. Our patient was rechallenged with imatinib 400 mg/day and had a partial response after one month of treatment. Imatinib rechallenge was well tolerated by our patient; the only adverse events she experienced were grade 1 edema, anemia and fatigue. Our patient maintained a partial response two years and six months after the imatinib rechallenge. However, computed tomography scans three months later showed that our patient had disease progression. Conclusions This case report demonstrates that a patient with a gastrointestinal stromal tumor who had previously received adjuvant imatinib therapy responded to imatinib rechallenge as treatment for her recurrent disease. These results indicate that imatinib sensitivity can be maintained in a patient with previous exposure to adjuvant imatinib therapy.

  2. Final Report Systems Level Analysis of the Function and Adaptive Responses of Methanogenic Consortia

    Energy Technology Data Exchange (ETDEWEB)

    Lovley, Derek R. [Univ. of Massachusetts, Amherst, MA (United States)

    2015-03-09

    performance of DIET may be strongly influenced by environmental factors. These studies have significantly modified conceptual models for carbon and electron flow in methane-producing environments and have developed a computational framework for predictive modeling the influence of environmental perturbations on methane-producing microbial communities. The results have important implications for modeling the response of methane-producing microbial communities to climate change as well as for the bioenergy strategy of converting wastes and biomass to methane.

  3. RPE in perfusion tissue culture and its response to laser application. Preliminary report.

    Science.gov (United States)

    Framme, Carsten; Kobuch, Karin; Eckert, Elfriede; Monzer, Jan; Roider, Johann

    2002-01-01

    To study the effects of conventional laser application on the retinal pigment epithelium (RPE) in a perfusion tissue culture model of porcine retinal pigment epithelium without overlying neurosensory retina. RPE with underlying choroid was prepared from enucleated porcine eyes and fixed in a holding ring (Minusheet). Specimens were then placed in two-compartment tissue culture containers (MinuCell & Minutissue, Bad Abbach, Germany) and were cultured during continuous perfusion with culture medium at both sides of the entire specimen, the upper RPE and the lower choroid (12 specimens out of 6 eyes). Cultures were kept for 1, 3, 7 and 14 days and were examined histologically. Laser treatment was performed on each tissue ring by application of 3 x 3 laser burns one day after culture began (argon ion laser, wavelength: 514 nm, pulse duration: 100 ms; spot size: 200 microm) using different energy levels (400-1,000 mW); (16 specimens out of 8 eyes). During laser treatment a marked lightening of the RPE with centrifugal spreading was observed. Using higher levels of energy, a contraction of the RPE towards the center of the laser spot was noticed. One day after laser photocoagulation histology revealed destruction of RPE; within 3-7 days of culture, migration and proliferation of neighboring cells was observed in several lesions. After 7 days the initial defect of the irradiated area was covered with dome shaped RPE cells and after 14 days multilayered RPE cells were showing ongoing proliferation. However, there were also cases without proliferation after laser treatment. The non-treated, continuously perfused RPE showed regular appearance in histological sections: during the first 7 days of culture, light microscopy revealed a normal matrix with a well-differentiated RPE monolayer. Subsequently proliferation even without treatment was observed and after 14 days the RPE became multilayered. It was possible to study the early healing response to the effect of laser

  4. Quantification of the antibody response to Propionibacterium acnes in a patient with prosthetic valve endocarditis: - a case report.

    Science.gov (United States)

    Herren, T; Middendorp, M A; Zbinden, R

    2016-04-29

    The isolation of Propionibacterium acnes in blood cultures is often considered a contaminant. On rare occasions, P. acnes can cause severe infections, including endocarditis and intravascular prosthesis-associated infections. To evaluate the discrimination between a contaminant and a clinically relevant infection we used an Ouchterlony test system to quantify the antibody response to P. acnes in a patient with a proven P. acnes endocarditis. We report on a 64-year-old Caucasian man who developed P. acnes endocarditis four years following a composite valve-graft conduit replacement of the aortic root. Bacterial growth in blood cultures was detected after an incubation period of 6 days. However, the antibody titer to P. acnes was 1:8 at the time of diagnosis and declined slowly thereafter over 2½ years. The patient's response to the antibiotic treatment was excellent, and no surgical re-intervention was necessary. The working hypothesis of infective endocarditis can be substantiated by serologic testing, which, if positive, provides one additional minor criterion. Moreover, quantification of the antibody response to P. acnes, though not specific, may assist in the differentiation between contaminants and an infection. This quantification may have implications for the patient management, e.g. indication for and choice of the antibiotic therapy.

  5. Response time scores on a reflexive attention task predict a child's inattention score from a parent report.

    Science.gov (United States)

    Lundwall, Rebecca A; Sgro, Jordan F; Fanger, Julia

    2018-01-01

    Compared to sustained attention, only a small proportion of studies examine reflexive attention as a component of everyday attention. Understanding the significance of reflexive attention to everyday attention may inform better treatments for attentional disorders. Children from a general population (recruited when they were from 9-16 years old) completed an exogenously-cued task measuring the extent to which attention is captured by peripheral cue-target conditions. Parents completed a questionnaire reporting their child's day-to-day attention. A general linear model indicated that parent-rated inattention predicted the increase in response time over baseline when a bright cue preceded the target (whether it was valid or invalid) but not when a dim cue preceded the target. More attentive children had more pronounced response time increases from baseline. Our findings suggest a link between a basic measure of cognition (response time difference scores) and parent observations. The findings have implications for increased understanding of the role of reflexive attention in the everyday attention of children.

  6. Atypical blood glucose response to continuous and interval exercise in a person with type 1 diabetes: a case report.

    Science.gov (United States)

    Moser, Othmar; Tschakert, Gerhard; Mueller, Alexander; Groeschl, Werner; Pieber, Thomas R; Koehler, Gerd; Eckstein, Max L; Bracken, Richard M; Hofmann, Peter

    2017-06-30

    Therapy must be adapted for people with type 1 diabetes to avoid exercise-induced hypoglycemia caused by increased exercise-related glucose uptake into muscles. Therefore, to avoid hypoglycemia, the preexercise short-acting insulin dose must be reduced for safety reasons. We report a case of a man with long-lasting type 1 diabetes in whom no blood glucose decrease during different types of exercise with varying exercise intensities and modes was found, despite physiological hormone responses. A Caucasian man diagnosed with type 1 diabetes for 24 years performed three different continuous high-intensity interval cycle ergometer exercises as part of a clinical trial (ClinicalTrials.gov identifier NCT02075567). Intensities for both modes of exercises were set at 5% below and 5% above the first lactate turn point and 5% below the second lactate turn point. Short-acting insulin doses were reduced by 25%, 50%, and 75%, respectively. Measurements taken included blood glucose, blood lactate, gas exchange, heart rate, adrenaline, noradrenaline, cortisol, glucagon, and insulin-like growth factor-1. Unexpectedly, no significant blood glucose decreases were observed during all exercise sessions (start versus end, 12.97 ± 2.12 versus 12.61 ± 2.66 mmol L -1 , p = 0.259). All hormones showed the expected response, dependent on the different intensities and modes of exercises. People with type 1 diabetes typically experience a decrease in blood glucose levels, particularly during low- and moderate-intensity exercises. In our patient, we clearly found no decline in blood glucose, despite a normal hormone response and no history of any insulin insensitivity. This report indicates that there might be patients for whom the recommended preexercise therapy adaptation to avoid exercise-induced hypoglycemia needs to be questioned because this could increase the risk of severe hyperglycemia and ketosis.

  7. Validity, reliability, and responsiveness of the Self-reported Foot and Ankle Score (SEFAS) in forefoot, hindfoot, and ankle disorders

    Science.gov (United States)

    2014-01-01

    Background and purpose The self-reported foot and ankle score (SEFAS) is a questionnaire designed to evaluate disorders of the foot and ankle, but it is only validated for arthritis in the ankle. We validated SEFAS in patients with forefoot, midfoot, hindfoot, and ankle disorders. Patients and methods 118 patients with forefoot disorders and 106 patients with hindfoot or ankle disorders completed the SEFAS, the foot and ankle outcome score (FAOS), SF-36, and EQ-5D before surgery. We evaluated construct validity for SEFAS versus FAOS, SF-36, and EQ-5D; floor and ceiling effects; test-retest reliability (ICC); internal consistency; and agreement. Responsiveness was evaluated by effect size (ES) and standardized response mean (SRM) 6 months after surgery. The analyses were done separately in patients with forefoot disorders and hindfoot/ankle disorders. Results Comparing SEFAS to the other scores, convergent validity (when correlating foot-specific questions) and divergent validity (when correlating foot-specific and general questions) were confirmed. SEFAS had no floor and ceiling effects. In patients with forefoot disorders, ICC was 0.92 (CI: 0.85–0.96), Cronbach's α was 0.84, ES was 1.29, and SRM was 1.27. In patients with hindfoot or ankle disorders, ICC was 0.93 (CI: 0.88-0.96), Cronbach's α was 0.86, ES was 1.05, and SRM was 0.99. Interpretation SEFAS has acceptable validity, reliability, and responsiveness in patients with various forefoot, hindfoot, and ankle disorders. SEFAS is therefore an appropriate patient- reported outcome measure (PROM) for these patients, even in national registries. PMID:24564747

  8. Evaluating Cumulative Ecosystem Response to Restoration Projects in the Columbia River Estuary, Annual Report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Diefenderfer, Heida L.; Roegner, Curtis; Thom, Ronald M.; Dawley, Earl M.; Whiting, Allan H.; Johnson, Gary E.; Sobocinski, Kathryn L.; Anderson, Michael G.; Ebberts, Blaine

    2005-12-15

    The restoration of wetland salmon habitat in the tidal portion of the Columbia River is occurring at an accelerating pace and is anticipated to improve habitat quality and effect hydrological reconnection between existing and restored habitats. Currently multiple groups are applying a variety of restoration strategies in an attempt to emulate historic estuarine processes. However, the region lacks both a standardized means of evaluating the effectiveness of individual projects as well as methods for determining the cumulative effects of all restoration projects on a regional scale. This project is working to establish a framework to evaluate individual and cumulative ecosystem responses to restoration activities in order to validate the effectiveness of habitat restoration activities designed to benefit salmon through improvements to habitat quality and habitat opportunity (i.e. access) in the Columbia River from Bonneville Dam to the ocean. The review and synthesis of approaches to measure the cumulative effects of multiple restoration projects focused on defining methods and metrics of relevance to the CRE, and, in particular, juvenile salmon use of this system. An extensive literature review found no previous study assessing the cumulative effects of multiple restoration projects on the fundamental processes and functions of a large estuarine system, although studies are underway in other large land-margin ecosystems including the Florida Everglades and the Louisiana coastal wetlands. Literature from a variety of scientific disciplines was consulted to identify the ways that effects can accumulate (e.g., delayed effects, cross-boundary effects, compounding effects, indirect effects, triggers and thresholds) as well as standard and innovative tools and methods utilized in cumulative effects analyses: conceptual models, matrices, checklists, modeling, trends analysis, geographic information systems, carrying capacity analysis, and ecosystem analysis. Potential

  9. Final Report: Optimal Model Complexity in Geological Carbon Sequestration: A Response Surface Uncertainty Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Ye [Univ. of Wyoming, Laramie, WY (United States)

    2018-01-17

    The critical component of a risk assessment study in evaluating GCS is an analysis of uncertainty in CO2 modeling. In such analyses, direct numerical simulation of CO2 flow and leakage requires many time-consuming model runs. Alternatively, analytical methods have been developed which allow fast and efficient estimation of CO2 storage and leakage, although restrictive assumptions on formation rock and fluid properties are employed. In this study, an intermediate approach is proposed based on the Design of Experiment and Response Surface methodology, which consists of using a limited number of numerical simulations to estimate a prediction outcome as a combination of the most influential uncertain site properties. The methodology can be implemented within a Monte Carlo framework to efficiently assess parameter and prediction uncertainty while honoring the accuracy of numerical simulations. The choice of the uncertain properties is flexible and can include geologic parameters that influence reservoir heterogeneity, engineering parameters that influence gas trapping and migration, and reactive parameters that influence the extent of fluid/rock reactions. The method was tested and verified on modeling long-term CO2 flow, non-isothermal heat transport, and CO2 dissolution storage by coupling two-phase flow with explicit miscibility calculation using an accurate equation of state that gives rise to convective mixing of formation brine variably saturated with CO2. All simulations were performed using three-dimensional high-resolution models including a target deep saline aquifer, overlying caprock, and a shallow aquifer. To evaluate the uncertainty in representing reservoir permeability, sediment hierarchy of a heterogeneous digital stratigraphy was mapped to create multiple irregularly shape stratigraphic models of decreasing geologic resolutions: heterogeneous (reference), lithofacies, depositional environment, and a (homogeneous) geologic formation. To ensure model

  10. Response to benzodiazepines and the clinical course in malignant catatonia associated with schizophrenia: A case report.

    Science.gov (United States)

    Ohi, Kazutaka; Kuwata, Aki; Shimada, Takamitsu; Yasuyama, Toshiki; Nitta, Yusuke; Uehara, Takashi; Kawasaki, Yasuhiro

    2017-04-01

    Malignant catatonia (MC) is a disorder consisting of catatonic symptoms, hyperthermia, autonomic instability, and altered mental status. Neuroleptic malignant syndrome (NMS) caused by antipsychotics is considered a variant of MC. Benzodiazepine (BZD) medications are safe and effective treatments providing rapid relief from MC. This case study reports a detailed clinical course of a case of MC associated with schizophrenia initially diagnosed as NMS that responded successfully to BZDs but not to dantrolene. A 53-year-old man with schizophrenia was admitted to the psychiatric hospital because of excitement, monologue, muscle rigidity, and insomnia. In the 3 days before admission, the patient had discontinued his medications after his family member's death. He presented with hyperthermia, tachycardia, hypertension, excessive sweating, and an elevated serum creatine phosphokinase (CPK) level. On the basis of these features, he was suspected to have NMS. The patient was treated with dantrolene for 7 days without improvement despite having a normalized serum CPK level. The patient was transferred to our university hospital for an in-depth examination and treatment of his physical status. Infection and pulmonary embolism were excluded as possible causes. To treat his excitement and auditory hallucination, an intravenous drip (IVD) of haloperidol was initiated, but this treatment increased the patient's catatonic and psychotic symptoms, although his serum CPK level had remained within a normal range. As a result, the treatment was changed to diazepam. After an IVD of diazepam, the patient's symptoms rapidly improved, and the IVD was subsequently replaced with oral administration of lorazepam. Eventually, the patient was diagnosed with MC associated with schizophrenia. BZD therapy was dramatically effective. Catatonia, MNS, and MC may be due to a common brain pathophysiology and these conditions may be in a spectrum, although uncertainty in the boundaries among conditions

  11. The CEGB/SSEB response to Recommendation 17 in the Environment Committee's Report on Radioactive Waste. V.1

    International Nuclear Information System (INIS)

    1986-11-01

    The first report from the Environment Committee concerning radioactive waste was published on 12th March 1986. Recommendation 17 of the Committee's report asked the CEGB and SSEB (the Home Boards) to carry out and publish an analysis of the costs of backfitting dry stores to Magnox stations and compare this with the costs of reprocessing, vitrification and subsequent storage of vitrified HLW. In addition the Committee asked that the Home Boards should examine the feasibility of drying Magnox spent fuel once it had been wet in the cooling ponds. This report represents the Home Boards' response to Recommendation 17. In addition, in order to provide a comprehensive economic comparison, consideration has also been given to the likely range of costs for treatment and final disposal of Magnox spent fuel. In carrying out this study the Home Boards have assessed the technical feasibility, costs and likely timescales associated with establishing new all-dry discharge routes on each of the individual Magnox stations and constructing dry storage facilities suitable for storing Magnox fuel for up to 100 years. (author)

  12. Clinical diagnosis and treatment of a patient with low back pain using the patient response model: A case report.

    Science.gov (United States)

    Robinson, Michael

    2016-05-01

    The medical management of low back pain (LBP) can be approached in a multitude of ways. Classification via subgrouping is increasingly common in orthopedic literature. Clinical diagnosis and treatment of LBP using the patient response model (PRM) can assist clinicians in hypothesizing the origin of pain and providing beneficial interventions unlike the widely used pathoanatomical model. This case report involved a 52-year-old female with sudden onset of right-sided LBP that radiated to the foot. These symptoms were accompanied by occasional paresthesias in bilateral lower extremities. Magnetic resonance imaging (MRI) confirmed disc bulges at levels T11-T12 and T12-L1. On the first of seven visits, she reported 9/10 on the Numeric Pain Rating Scale (NPRS), scored a 24/50 on the modified Oswestry disability index (mODI), and demonstrated lumbar flexion range of motion (ROM) of 10°. Using the PRM, the patient was classified as an extension responder and was instructed to perform 10 repetitions of standing lumbar extension every 2 waking hours. After 4 weeks of therapy, the patient reported a 1/10 pain localized to the low back, scored 20/50 on the mODI, and improved flexion ROM to 45°. Classification using the PRM yielded positive outcomes with this patient's symptoms and daily function.

  13. Exploring Corporate Social Responsibility in Foreign Bank Branches from Romania: An Empirical Analysis of Public Disclosure of Financial Statements and Banking Audit Reports

    Directory of Open Access Journals (Sweden)

    Attila TAMAS-SZORA

    2015-09-01

    Full Text Available The purpose of this study is to investigate the Corporate Social Responsibility CSR/the Social Responsibility Disclosure SRD reporting practices referring to the published banking financial statements and the published auditors' reports. The study was conducted on the foreign bank branches from Romania and is based on their Romanian language web-sites, that constitute the data for the analysis. The results show that voluntary CSR/SRD concepts to disclose the financial statements and the auditors' reports on the Romanian web-sites were applied only by two from nine foreign bank branches. We plead for a social responsibility of the banks, even if they are foreign bank branches that conduct their activities according to the law from their origin countries. Disclosing the economic outputs via web-site could contribute to a high level of banks' transparency and makes part from the responsibility to society into the Corporate Social Responsibility CSR concept.

  14. Report: EPA’s Information Systems and Data Are at Risk Due to Insufficient Training of Personnel With Significant Information Security Responsibilities

    Science.gov (United States)

    Report #14-P-0142, March 21, 2014. The EPA places its information systems and data at risk due to an organizational structure that has not specified required duties and responsibilities to ensure personnel are trained on key information security roles.

  15. ECR 2000 : the annual report of the Environmental Commitment and Responsibility Program of the Canadian Electricity Association

    International Nuclear Information System (INIS)

    2001-09-01

    The Environmental Commitment and Responsibility (ECR) Program is an industry-wide initiative of the Canadian Electricity Association. The program, launched in 1997, builds on individual initiatives of member utilities and provides a forum to address the industry's commitment to sustainable development and better environmental performance. This annual report focuses on air quality issues for the electricity industry with emphasis on the challenge of airborne mercury and climate change. It also includes a report card from the public advisory panel. In their Letter to the Industry, the panel members expressed their support for the ECR initiative and commended the program participants. This report also presented a series of actions that may be taken to address all of the Panel's recommendations. Some member utilities have put principles into action by developing and deploying alternative energy technologies, such as wind, solar and small run of river hydro electric power. These sources are becoming more cost competitive and have potentially less impact on the environment. The industry is also enhancing the many different fuel types available throughout Canada. Environmental performance highlights and trends for the year 2000 were also presented. While no new trends emerged in 2000, indicators show a continuing and steady improvement in environmental performance in all areas, even with the significant increase in fossil fuel power generation. It was emphasized that in order to meet the rising demand for energy, other measures must be taken, including new capacity and infrastructure, and energy management programs. The increased capital investment for these initiatives will require adequate market prices that reflect the long term value of electrical energy. This report demonstrates the industry's commitment to conduct their business with respect for the natural environment and social expectations. tabs., figs

  16. Delayed Treatment Response in a Neonate with Multisystem Langerhans Cell Histiocytosis: Case report and review of literature

    Directory of Open Access Journals (Sweden)

    Amitabh Singh

    2017-06-01

    Full Text Available Langerhans cell histiocytosis (LCH is a rare proliferative disorder of the Langerhans cells, which are part of the mononuclear phagocytic system. The disorder varies in terms of the extent of the disease, its natural course and patient outcomes. While skin rashes are a common presentation of neonatal LCH, other systems or organs may also be involved. Delays in the diagnosis of neonatal LCH may occur due to its non-specific presentation and a lack of awareness of the condition among doctors. We report a two-month-old male neonate who presented to the Chacha Nehru Bal Chikitsalya hospital, New Delhi, India, in 2016 after the onset of pulmonary symptoms. He had been noted to have a generalised rash which had progressively worsened from 15 days of age. Following a skin biopsy and chest imaging, he was diagnosed with multisystem LCH with risk organ involvement. There was a delayed response to combined chemotherapy with no major side-effects.

  17. Need to Belong, Not Rejection Sensitivity, Moderates Cortisol Response, Self-Reported Stress, and Negative Affect Following Social Exclusion.

    Science.gov (United States)

    Beekman, Janine B; Stock, Michelle L; Marcus, Tara

    2016-01-01

    The present study examined if the traits need to belong (NTB) and rejection sensitivity (RS) differentially moderate the impact of experimentally manipulated social exclusion on stress and affect. Participants (N = 132) completed a survey measuring NTB and RS, and then were randomly assigned to be included or excluded during a game of Cyberball. A second survey then assessed perceived stress and negative affect, and a cortisol sample was taken. Controlling for gender and baseline cortisol levels, excluded participants high (vs. low) in NTB had significantly higher postexclusion cortisol levels, and reported greater perceived stress and negative affect. The moderating effect for RS was not found, however, and NTB and RS were not correlated. Findings suggest that the NTB moderates psychological and physiological responses to exclusion.

  18. Validity, Reliability And Responsiveness Of Patient-Reported Outcome Questionnaires When Assessing Hip And Groin Disability: A Systematic Review

    DEFF Research Database (Denmark)

    Thorborg, Kristian; Roos, Ewa; Bartels, Else Marie

    2010-01-01

    Background Novel treatment interventions are advancing rapidly in the management of hip and groin disability in the physically active young to middle-aged population. Objective To recommend the most suitable patient-reported outcome (PRO) questionnaires for the assessment of hip and groin...... disability based on a systematic review of evidence of validity, reliability and responsiveness of these instruments. Methods MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, PsycINFO, SportsDiscus and Web of Science were all searched up to January 2009. Two reviewers independently...... osteoarthritis (OA) or total hip replacement (THR). Hip Outcome Score (HOS) is the best available questionnaire for evaluating hip arthroscopy, but the Inguinal Pain Questionnaire, the only identified questionnaire evaluating groin disability, does not contain adequate measurement qualities. Conclusions HOOS...

  19. Food-cue affected motor response inhibition and self-reported dieting success: a pictorial affective shifting task

    Directory of Open Access Journals (Sweden)

    Adrian eMeule

    2014-03-01

    Full Text Available Behavioral inhibition is one of the basic facets of executive functioning and is closely related to self-regulation. Impulsive reactions, i.e. low inhibitory control, have been associated with higher body-mass-index (BMI, binge eating, and other problem behaviors (e.g. substance abuse, pathological gambling, etc.. Nevertheless, studies which investigated the direct influence of food-cues on behavioral inhibition have been fairly inconsistent. In the current studies, we investigated food-cue affected behavioral inhibition in young women. For this purpose, we used a go/no-go task with pictorial food and neutral stimuli in which stimulus-response mapping is reversed after every other block (affective shifting task. In study 1, hungry participants showed faster reaction times to and omitted fewer food than neutral targets. Low dieting success and higher BMI were associated with behavioral disinhibition in food relative to neutral blocks. In study 2, both hungry and satiated individuals were investigated. Satiation did not influence overall task performance, but modulated associations of task performance with dieting success and self-reported impulsivity. When satiated, increased food craving during the task was associated with low dieting success, possibly indicating a preload-disinhibition effect following food intake. Food-cues elicited automatic action and approach tendencies regardless of dieting success, self-reported impulsivity, or current hunger levels. Yet, associations between dieting success, impulsivity, and behavioral food-cue responses were modulated by hunger and satiation. Future research investigating clinical samples and including other salient non-food stimuli as control category is warranted.

  20. Report on workshop to incorporate basin response in the design of tall buildings in the Puget Sound region, Washington

    Science.gov (United States)

    Chang, Susan; Frankel, Arthur D.; Weaver, Craig S.

    2014-01-01

    On March 4, 2013, the City of Seattle and the U.S. Geological Survey (USGS) convened a workshop of 25 engineers and seismologists to provide recommendations to the City for the incorporation of amplification of earthquake ground shaking by the Seattle sedimentary basin in the design of tall buildings in Seattle. The workshop was initiated and organized by Susan Chang, a geotechnical engineer with the City of Seattle Department of Planning and Development, along with Art Frankel and Craig Weaver of the USGS. C.B. Crouse of URS Corporation, Seattle made key suggestions for the agenda. The USGS provided travel support for most of the out-of-town participants. The agenda and invited attendees are given in the appendix. The attendees included geotechnical and structural engineers working in Seattle, engineers with experience utilizing basin response factors in other regions, and seismologists who have studied basin response in a variety of locations. In this report, we summarize the technical presentations and the recommendations from the workshop.

  1. Development of electrochemical reporter assay using HeLa cells transfected with vector plasmids encoding various responsive elements

    Energy Technology Data Exchange (ETDEWEB)

    Shiku, Hitoshi, E-mail: shiku@bioinfo.che.tohoku.ac.jp [Graduate School of Environmental Studies, Tohoku University, 6-6-11-604 Aramaki-Aoba, Sendai 980-8579 (Japan); Takeda, Michiaki; Murata, Tatsuya [Graduate School of Environmental Studies, Tohoku University, 6-6-11-604 Aramaki-Aoba, Sendai 980-8579 (Japan); Akiba, Uichi; Hamada, Fumio [Graduate School of Engineering and Resource Science, Akita University, 1-1 Tegata gakuen-machi, Akita 010-8502 (Japan); Matsue, Tomokazu, E-mail: matsue@bioinfo.che.tohoku.ac.jp [Graduate School of Environmental Studies, Tohoku University, 6-6-11-604 Aramaki-Aoba, Sendai 980-8579 (Japan)

    2009-04-27

    Electrochemical assay using HeLa cell lines transfected with various plasmid vectors encoding SEAP (secreted alkaline phosphatase) as the reporter has been performed by using SECM (scanning electrochemical microscopy). The plasmid vector contains different responsive elements that include GRE (glucocorticoid response elements), CRE (cAMP responsive elements), or {kappa}B (binding site for NF{kappa}B (nuclear factor kappa B)) upstream of the SEAP sequence. The transfected HeLa cells were patterned on a culture dish in a 4 x 4 array of circles of diameter 300 {mu}m by using the PDMS (poly(dimethylsiloxane)) stencil technique. The cellular array was first exposed to 100 ng mL{sup -1} dexamethasone, 10 ng mL{sup -1} forskolin, or 100 ng mL{sup -1} TNF-{alpha} (tumor necrosis factor {alpha}) after which it was further cultured in an RPMI culture medium for 6 h. After incubation, the cellular array was soaked in a measuring solution containing 4.7 mM PAPP (p-aminophenylphosphate) at pH 9.5, following which electrochemical measurements were performed immediately within 40 min. The SECM method allows parallel evaluation of different cell lines transfected with pGRE-SEAP, pCRE-SEAP, and pNF{kappa}B-SEAP patterned on the same solid support for detection of the oxidation current of PAP (p-aminophenol) flux produced from only 300 HeLa cells in each stencil pattern. The results of the SECM method were highly sensitive as compared to those obtained from the conventional CL (chemiluminescence) protocol with at least 5 x 10{sup 4} cells per well.

  2. Monitoring the athlete training response: subjective self-reported measures trump commonly used objective measures: a systematic review.

    Science.gov (United States)

    Saw, Anna E; Main, Luana C; Gastin, Paul B

    2016-03-01

    Monitoring athlete well-being is essential to guide training and to detect any progression towards negative health outcomes and associated poor performance. Objective (performance, physiological, biochemical) and subjective measures are all options for athlete monitoring. We systematically reviewed objective and subjective measures of athlete well-being. Objective measures, including those taken at rest (eg, blood markers, heart rate) and during exercise (eg, oxygen consumption, heart rate response), were compared against subjective measures (eg, mood, perceived stress). All measures were also evaluated for their response to acute and chronic training load. The databases Academic search complete, MEDLINE, PsycINFO, SPORTDiscus and PubMed were searched in May 2014. Fifty-six original studies reported concurrent subjective and objective measures of athlete well-being. The quality and strength of findings of each study were evaluated to determine overall levels of evidence. Subjective and objective measures of athlete well-being generally did not correlate. Subjective measures reflected acute and chronic training loads with superior sensitivity and consistency than objective measures. Subjective well-being was typically impaired with an acute increase in training load, and also with chronic training, while an acute decrease in training load improved subjective well-being. This review provides further support for practitioners to use subjective measures to monitor changes in athlete well-being in response to training. Subjective measures may stand alone, or be incorporated into a mixed methods approach to athlete monitoring, as is current practice in many sport settings. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  3. Impaired Physical Performance and Clinical Responses after a Recreational Bodybuilder's Self-Administration of Steroids: A Case Report

    Science.gov (United States)

    Veras, Katherine; Silva-Junior, Fernando Lopes; Lima-Silva, Adriano Eduardo; De-Oliveira, Fernando Roberto

    2015-01-01

    We reported clinical and physical responses to 7 weeks of anabolic-androgenic steroid (AAS) self-administration in a male recreational bodybuilder. He was self-administrating a total of 3,250 mg of testosterone when his previous and current clinical and physical trials records were revisited. Body shape, performance, and biochemistry results were clustered into three phases labeled PRE (before the self-use), POST I (immediately at the cessation of the 7-week administration), and POST II (12 weeks after the cessation). Elevated testosterone and estradiol levels were observed in the POST I phase, while hepatic and renal functions remained altered in the POST II phase. Body mass and body fat percentages increased throughout the three phases. When adjusted according to body mass, drops in aerobic and anaerobic power and capacity (2.1% to 12.9%) were observed across the phases. This case report shows that overall performance decreased when a bodybuilding practitioner self-administered AAS. PMID:26770942

  4. Federal response to the environmental assessment report of the NRCB-CEAA joint review panel on the Little Bow project/Highwood diversion plan

    International Nuclear Information System (INIS)

    1999-01-01

    In June 1998, a joint review panel released a report on a dam and diversion project proposed by Alberta Public Works, Supply and Services. This document is the response to that report addressing its recommendations to the federal government and other recommendations or statements pertinent to federal areas of jurisdiction and interest. It begins with background on the proposed project, then presents the report's recommendations or statements along with the federal responses with regard to the following issue areas: Regulatory approval; navigable waters and the public right of navigation; fish and fish habitat; wetlands and wildlife; and Aboriginal concerns

  5. Comment response document for the Secretary of Energy`s ``Report to Congress on Reassessment of the Civilian Radioactive Waste Management Program``

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-11-01

    On November 29, 1989, the Secretary of Energy published his ``Report to Congress on the Reassessment of the Civilian Radioactive Waste Management Program`` (Report), and sent copies to numerous interested parties for their review and comment. This document summarizes comments received on the Report and presents the DOE`s current responses to those comments as a basis for further discussions. Included as appendixes are a list of commenters, a crosswalk showing where each comment is addressed, the comment letters themselves with specific comments delineated, and the DOE`s response to those letters. Twenty-five individuals or organizations submitted comments on the Report. The DOE identified 130 individual comments and classified them into the following seven categories: Management, Institutional, Regulatory, Transportation, Monitored Retrievable Storage, Scheduling, and Yucca Mountain. For the responses, comments were than grouped into more specific topics under each of the major headings. The DOE attempted to respond to all comments.

  6. Policy responses to hepatitis C in the Nordic countries: Gaps and discrepant reporting in the Hep-Nordic study.

    Directory of Open Access Journals (Sweden)

    Kelly Safreed-Harmon

    Full Text Available In the Nordic countries (Denmark, Finland, Iceland, Norway, Sweden, the prevalence of chronic hepatitis C virus (HCV infection is relatively low in the general population, but is much higher among people who inject drugs (PWID. We conducted an exploratory study to investigate the extent to which these countries have policies supporting key elements of the public health response that is necessary to achieve the global goal of eliminating HCV as a public health threat.Fourteen stakeholders representing government agencies, medical societies, and civil society organisations (CSOs in the Nordic countries completed a cross-sectional online survey that included 21 policy questions related to national coordination, prevention, testing, linkage to care, and treatment. We summarised the findings in a descriptive analysis, and noted discrepant responses from stakeholders within the same country.Stakeholders reported that three of the five study countries have national viral hepatitis strategies, while only Iceland has a national HCV elimination goal. The availability of harm reduction services varies, with opioid substitution therapy provided for the general population throughout all countries, but not needle and syringe programmes. No country has access to anonymous HCV testing in all parts of the country. National HCV treatment guidelines are available in all countries except Finland, and all countries provide publicly funded direct-acting antiviral treatment. Disagreement regarding policies was observed across countries, and CSOs were the stakeholder group that most frequently answered survey questions incorrectly.The Nordic region as a whole has not consistently expressed its commitment to tackling HCV, despite the existence of large HCV epidemics among PWID in these countries. Stakeholder alignment and an established elimination goal with an accompanying strategy and implementation plan should be recognised as the basis for coordinated national

  7. Proposal of early retreatment with iloprost in partially responsive patients with bone marrow edema syndrome: a case report

    Directory of Open Access Journals (Sweden)

    Simone Meini

    2012-12-01

    Full Text Available Background Avascular Necrosis (AVN is defined as the cellular death of bone components due to an alteration of the blood supply, resulting in Edema of the Bone Marrow (BME, structural collapse and bone destruction. In advanced stages, AVN requires surgery. One emerging medical treatment for supporting osseous perfusion is the administration of iloprost.Materials and methods A 38-year-old woman presented with severe BME of the left hip (primary, persisting for 6 weeks. She was treated with iloprost iv at 2 ng/kg/min for 6 hours/day for 5 days, and after 4 weeks, the treatment was repeated at 1.5 ng/kg/min for 6 hours for 5 days because she exhibited only a partial response to the first treatment. Complete remission was obtained, documented clinically and on Magnetic Resonance Imaging (MRI. Her Harris Hip Score (HHS increased from 29.90 to 97. No significant adverse events related to iloprost were registered. No surgical procedures were necessary.Conclusions In most cases, iloprost is administered in a single cycle of treatment over 5 days at 1-2 ng/kg/min for 6 hours/day, but no research has investigated the effectiveness of early retreatment after the first cycle results in only a partially response. Only a few studies examining small numbers of patients have evaluated iloprost in AVN/BME, preferring, in most cases, the dose of 1 ng/kg/min and obtaining clinical improvement both in BME and in AVN in times comparable to surgical core decompression. This case report demonstrates the safety and effectiveness of early repetition of the maximal dose of iloprost before BME evolves into AVN, as well as in cases initially appearing serious and requiring surgical procedures.

  8. Urinary bladder dose-response relationships for patient-reported genitourinary morbidity domains following prostate cancer radiotherapy.

    Science.gov (United States)

    Thor, Maria; Olsson, Caroline; Oh, Jung Hun; Petersen, Stine Elleberg; Alsadius, David; Bentzen, Lise; Pettersson, Niclas; Muren, Ludvig Paul; Høyer, Morten; Steineck, Gunnar; Deasy, Joseph O

    2016-04-01

    Radiotherapy (RT) induced genitourinary (GU) morbidity is typically assessed by physicians as single symptoms or aggregated scores including symptoms from various domains. Here we apply a method to group patient-reported GU symptoms after RT for localized prostate cancer based on their interplay, and study how these relate to urinary bladder dose. Data were taken from two Scandinavian studies (N=207/276) including men treated with external-beam RT (EBRT) to 78/70Gy (2Gy/fraction; median time-to-follow-up: 3.6-6.4y). Within and across cohorts, bladder dose-volume parameters were tested as predictors for GU symptom domains identified from two study-specific questionnaires (35 questions on frequency, incontinence, obstruction, pain, urgency, and sensory symptoms) using univariate and multivariate logistic regression analysis (MVA) with 10-fold cross-validation. Performance was evaluated using Area Under the Receiver Operating Characteristic Curve (Az). For the identified Incontinence (2-5 symptoms), Obstruction (3-5 symptoms), and Urgency (2-7 symptoms) domains, MVA demonstrated that bladder doses close to the prescription doses were the strongest predictors for Obstruction (Az: 0.53-0.57) and Urgency (Az: 0.60). For Obstruction, performance increased for the across cohort analysis (Az: 0.61-0.64). Our identified patient-reported GU symptom domains suggest that high urinary bladder doses, and increased focus on both obstruction and urgency is likely to further add to the understanding of GU tract RT responses. Published by Elsevier Ireland Ltd.

  9. Daily diary reports of social connection, objective sleep, and the cortisol awakening response during adolescents' first year of college.

    Science.gov (United States)

    Sladek, Michael R; Doane, Leah D

    2015-02-01

    Poor sleep and alterations in the stress-sensitive hypothalamic-pituitary-adrenal (HPA) axis may be mechanisms through which loneliness impacts adolescents' well-being. Few researchers have explored whether daily variation in experiences of social connection predict day-to-day variation in sleep and HPA axis activity among adolescents navigating the college context. Using daily diary reports of social connection, objective measures of sleep (actigraphy), and naturalistic salivary assessment, the present study examined within-person associations between first-year college students' social connection during the day and sleep that night, as well as diurnal cortisol activity the following day. The present study also explored trait-level loneliness as a moderator of these associations after adjusting for baseline loneliness assessed in high school. Seventy-one first-year college students (23% male; M age = 18.85; 52% non-Hispanic White) completed daily diary reports, wore a wrist-based accelerometer (actigraph watch), and provided saliva samples five times daily across three consecutive weekdays. The results from hierarchical linear models indicated that within-person increases in daily social connection were significantly associated with longer time spent in bed and more actual time asleep that night only for adolescents high on loneliness. Within-person increases in daily social connection were associated with a greater cortisol awakening response (CAR) the next day, regardless of trait loneliness. These findings illustrate that more daily social connection with others than usual may predict improved sleep quantity for lonely adolescents and a physiological index of anticipating upcoming daily demands (CAR) in general. Future intervention programs might consider including strategies focused on enhancing daily social interactions among adolescents starting college, particularly for lonely adolescents.

  10. Plant response to FBC waste-coal slurry solid mixtures. Technical report, 1 March--31 May 1994

    Energy Technology Data Exchange (ETDEWEB)

    Darmody, R.G.; Dunker, R.E. [Univ. of Illinois, Urbana, IL (United States); Dreher, G.B.; Roy, W.R.; Steel, J.D. [Illinois State Geological Survey, Champaign, IL (United States)

    1994-09-01

    The goal of this project is to test the feasibility of stabilizing coal slurry solids (CSS) wastes by directly seeding plants into the waste. This is not done conventionally because the waste can generate toxic amounts of sulfuric acid. The approach is to neutralize the potential acidity by mixing fluidized bed combustion (FBC) waste into the slurry. If successful, this approach would both help dispose of FBC wastes while providing a more economical slurry stabilization technique. The project involves growing forage plants in CSS-FBC mixtures in the greenhouse. In the first two quarters the authors designed the experiment, secured greenhouse space, purchased the seeds, collected, dried, analyzed the FBC and CSS samples. The samples represent a typical range of properties. They retrieved two FBC and two CSS samples. One CSS sample had a relatively high CaCO{sub 3} content relative to the pyrite content and required no FBC to neutralize the potential acidity. The other CSS sample required from 4.2 to 2.7% FBC material to neutralize its potential acidity. This report covers the third quarter of the project. The authors produced the CSS-FBC mixtures, analyzed the soil fertility parameters of the mixtures,, planted the crops, and monitored their growth. All mixtures support at least some plant growth, although some plants did better than others. It is too early to analyze the results statistically. Next quarter the plants will be harvested, yields calculated, mineral uptake evaluated, and a final report will be written on plant response to CSS-FBC mixtures.

  11. Analisis Pengungkapan Corporate Social Responsibility Berdasarkan Global Reporting Initiatives (GRI:Studi Kasus Perusahaan Tambang Batubara Bukit Asam (Persero Tbk dan Timah (Persero Tbk.

    Directory of Open Access Journals (Sweden)

    Nuraini Sari

    2014-11-01

    Full Text Available This study aims to provide an overview of the disclosure of Corporate Social Responsibility (CSR in the mining company's corporate sustainability report. It is also to analyze the disclosure of Corporate Social Responsibility (CSR in corporate sustainability report with standard Global Reporting Initiatives (GRI 3.1. Research was conducted in Batubara Bukit Asam (Persero Tbk. and Timah (Persero Tbk. on their corporatesustainability report for the year of 2012. The analysis was conducted on the presentation of economic performance indicator, environmental performance indicator, performance indicators of employment and workplace practices, human rights performance indicator, public performance indicator and performance indicator reported products liability provisions established in the GRI 3.1. The result is the two companies havedisclosed CSR in accordance with GRI3.1. Batubara Bukit Asam (Persero Tbk and Timah (Persero Tbk have disclosed their performance indicators; and the average has exceeded 75%. However, the disclosure of each indicator and its aspects are not comprehensive.

  12. Social Desirability Response Bias and Other Factors That May Influence Self-Reports of Substance Use and HIV Risk Behaviors: A Qualitative Study of Drug Users in Vietnam.

    Science.gov (United States)

    Latkin, Carl A; Mai, Nguyen Vu Tuyet; Ha, Tran Viet; Sripaipan, Teerada; Zelaya, Carla; Le Minh, Nguyen; Morales, Giuliana; Go, Vivian F

    2016-10-01

    The accuracy of self-report data may be marred by a range of cognitive and motivational biases, including social desirability response bias. The current study used qualitative interviews to examine self-report response biases among participants in a large randomized clinical trial in Vietnam. A sample of study participants was reinterviewed. The vast majority reported being truthful and emphasized the importance of rapport with the study staff for achieving veridical data. However, some stated that rapport may lead to under reporting of risk behaviors in order not to disappoint study staff. Other factors that appeared to influence accuracy of self-reports include fear that the information may be divulged, desire to enroll in the study, length of the survey, and memory. There are several methods that can be employed to reduce response biases, and future studies should systematically address response bias and include methods to assess whether approaches and survey items are effective in improving accuracy of self-report data.

  13. Social Desirability and Self-Reports: Testing a Content and Response-Style Model of Socially Desirable Responding

    Directory of Open Access Journals (Sweden)

    Arta Dodaj

    2012-11-01

    Full Text Available Personality assessment as a pre-employment screening procedure receives great interest from both researchers and practitioners. One key concern for selection specialists is represented by the response distortion among job applicants completing personality inventories. There are different operationalizations of socially desirable responding. One of the most accepted operationalizations was provided by Paulhus who distinguished between two social desirability factors (the egoistic and moralistic bias as well as their conscious and unconscious aspects (management and enhancement. The aim of the study reported here is to test the basic assumption of the Paulhus model of socially desirable responding. A convenience sample of 200 students (N = 21.61; SD = 1.46 completed the Comprehensive Inventory of Desirable Responding (Paulhus, 2006 and the International Personality Item Pool Questionnaire (Goldberg, 1999; by Goldberg et al., 2006. Questionnaires were applied in three conditions: honest responding, responding as an ideal manager job applicant, and as an ideal teacher applicant. Results give partial support to the existence of egoistic and moralistic bias. However, conscious and unconscious aspects of distortion were not found. In conclusion it could be said that Paulhus’ model doesn’t provide a full answer to the problem of the nature of socially desirable responding.

  14. Confirmatory Factor Analysis of the Patient Reported Outcomes Measurement Information System (PROMIS) Adult Domain Framework Using Item Response Theory Scores.

    Science.gov (United States)

    Carle, Adam C; Riley, William; Hays, Ron D; Cella, David

    2015-10-01

    To guide measure development, National Institutes of Health-supported Patient reported Outcomes Measurement Information System (PROMIS) investigators developed a hierarchical domain framework. The framework specifies health domains at multiple levels. The initial PROMIS domain framework specified that physical function and symptoms such as Pain and Fatigue indicate Physical Health (PH); Depression, Anxiety, and Anger indicate Mental Health (MH); and Social Role Performance and Social Satisfaction indicate Social Health (SH). We used confirmatory factor analyses to evaluate the fit of the hypothesized framework to data collected from a large sample. We used data (n=14,098) from PROMIS's wave 1 field test and estimated domain scores using the PROMIS item response theory parameters. We then used confirmatory factor analyses to test whether the domains corresponded to the PROMIS domain framework as expected. A model corresponding to the domain framework did not provide ideal fit [root mean square error of approximation (RMSEA)=0.13; comparative fit index (CFI)=0.92; Tucker Lewis Index (TLI)=0.88; standardized root mean square residual (SRMR)=0.09]. On the basis of modification indices and exploratory factor analyses, we allowed Fatigue to load on both PH and MH. This model fit the data acceptably (RMSEA=0.08; CFI=0.97; TLI=0.96; SRMR=0.03). Our findings generally support the PROMIS domain framework. Allowing Fatigue to load on both PH and MH improved fit considerably.

  15. Report

    Directory of Open Access Journals (Sweden)

    Akin Aydogan

    2012-01-01

    Full Text Available Introduction. Gossypiboma (GP is a term used to express the mass resulting from forgotten cotton sponge in operations. Rarely, a transmural migration may occur into the gastrointestinal lumen without creating any defect by GP. Laparotomy or endoscopic removal may be required, by the way it can be taken out of the body itself by intestinal ways. In this study, we reported a case of mechanical intestinal obstruction causing GP. Case. The fifty-one-year-old female patient admitted to the emergency department with the complaints of mechanical intestinal obstruction and had a history of open cholecystectomy 20 years ago. There were the findings of intestinal obstruction in abdominal plain radiography and computerized tomography. The sponge that obstructed the lumen completely 40 cm proximal to the ileocecal valve was identified in the laparotomy with the diagnosis of brid ileus. The small intestine was closed over double-fold after removal of sponge. Transmural migration of abdominal-remained sponge was thought to be occurred without creating a defect after cholecystectomy. Postoperatively, the patient was discharged without having any problems at 4th day of hospitalization. Conclusion. Although it is a rare situation in routine clinical practice, GP should be considered as a differential diagnosis in the patients who had a diagnosis of mechanical intestinal obstruction, and laparotomy was applied before. As GP may lead to situations which cause mortality, all precautions should be taken to prevent it.

  16. Mass-casualty terrorist bombings in Istanbul, Turkey, November 2003: report of the events and the prehospital emergency response.

    Science.gov (United States)

    Rodoplu, Ulkümen; Arnold, Jeffrey L; Tokyay, Rifat; Ersoy, Gurkan; Cetiner, Serkan; Yücel, Tayfun

    2004-01-01

    This paper describes the two mass-casualty, terrorist attacks that occurred in Istanbul, Turkey in November 2003, and the resulting pre-hospital emergency response. A complex, retrospective, descriptive study was performed, using open source reports, interviews, direct measurements of street distances, and hospital records from the American Hospital (AH) and Taksim Education and Research State Hospital (TERSH) in Istanbul. On 15 November, improvised explosive devices (IEDs) in trucks were detonated outside the Neve Shalom and Beth Israel Synagogues, killing 30 persons and injuring an estimated additional 300. Victims were maldistributed to 16 medical facilities. For example, AH, a private hospital located six km from both synagogues, received 69 injured survivors, of which 86% had secondary blast injuries and 13% were admitted to the hospital. The TERSH, a government hospital located 1 km from both synagogues, received 48 injured survivors. On 20 November, IEDs in trucks were detonated outside the Hong Kong Shanghai Banking Corporation (HSBC) headquarters and the British Consulate (BC), killing 33 and injuring an estimated additional 450. Victims were maldistributed to 16 medical facilities. For example, TERSH, located 18 km from the HSBC site and 2 km from the the BC received 184 injured survivors, of which 93% had secondary blast injuries and 15% were hospitalized. The AH, located 9 km from the HSBC site and 6 km from the BC, received 16 victims. The twin suicide truck bombings on 15 and 20 November 2003 were the two largest terrorist attacks in modern Turkish history, collectively killing 63 persons and injuring an estimated 750 others. The vast majority of victims had secondary blast injuries, which did not require hospitalization. Factors associated with the maldistribution of casualties to medical facilities appeared to include the distance from each bombing site, the type of medical facility, and the personal preference of injured survivors.

  17. The Effects of Television Advertising on Children. Report No. 6: Survey of Pre-Adolescent's Responses to Television Commercials. Final Report.

    Science.gov (United States)

    Atkin, Charles K.

    This report, the last in a series of six reports on television advertising and children, describes patterns of advertising exposure and evaluation in the naturalistic setting and examines the role of commercials in late childhood socialization. An omnibus questionnaire was administered to 775 fourth through seventh grade students in urban,…

  18. Young drivers' responses to anti-speeding advertisements: Comparison of self-report and objective measures of persuasive processing and outcomes.

    Science.gov (United States)

    Kaye, Sherrie-Anne; Lewis, Ioni; Algie, Jennifer; White, Melanie J

    2016-05-18

    Self-report measures are typically used to assess the effectiveness of road safety advertisements. However, psychophysiological measures of persuasive processing (i.e., skin conductance response [SCR]) and objective driving measures of persuasive outcomes (i.e., in-vehicle Global Positioning System [GPS] devices) may provide further insights into the effectiveness of these advertisements. This study aimed to explore the persuasive processing and outcomes of 2 anti-speeding advertisements by incorporating both self-report and objective measures of speeding behavior. In addition, this study aimed to compare the findings derived from these different measurement approaches. Young drivers (N = 20, M age = 21.01 years) viewed either a positive or negative emotion-based anti-speeding television advertisement. While viewing the advertisement, SCR activity was measured to assess ad-evoked arousal responses. The RoadScout GPS device was then installed in participants' vehicles for 1 week to measure on-road speed-related driving behavior. Self-report measures assessed persuasive processing (emotional and arousal responses) and actual driving behavior. There was general correspondence between the self-report measures of arousal and the SCR and between the self-report measure of actual driving behavior and the objective driving data (as assessed via the GPS devices). This study provides insights into how psychophysiological and GPS devices could be used as objective measures in conjunction with self-report measures to further understand the persuasive processes and outcomes of emotion-based anti-speeding advertisements.

  19. Newly constructed stable reporter cell lines for mechanistic studies on electrophile-responsive element-mediated gene expression reveal a role for flavonoid planarity

    NARCIS (Netherlands)

    Boerboom, A.M.J.F.; Vermeulen, M.; Woude, H. van der; Bremer, B.I.; Lee-Hilz, Y.Y.; Kampman, E.; Bladeren, P.J. van; Rietjens, I.M.C.M.; Aarts, J.M.M.J.G.

    2006-01-01

    The electrophile-responsive element (EpRE) is a transcriptional enhancer involved in cancer-chemoprotective gene expression modulation by certain food components. Two stably transfected luciferase reporter cell lines were developed, EpRE(hNQO1)-LUX and EpRE(mGST-Ya)-LUX, based on EpRE sequences from

  20. The Role of Occupational Therapists and Physical Therapists in Elementary School System Early Intervening Services and Response to Intervention: A Case Report

    Science.gov (United States)

    Reeder, Deborah L.; Arnold, Sandra H.; Jeffries, Lynn M.; McEwen, Irene R.

    2011-01-01

    The Individuals with Disabilities Improvement Act and No Child Left Behind Act broadened the roles of occupational therapists (OTs) and physical therapists (PTs) to include therapist participation in early intervening services including response to intervention (RTI). This case report describes one school district's inclusion of OT and PT in the…

  1. The Identification and Evaluation of Flight Test Categories of Responsiveness in Reporting Weapon System Test Program Information by the 4950TH Test Wing.

    Science.gov (United States)

    1989-09-01

    Test must establish the responsibilities and data flow between the qPO and the RTO. This is not an easy task, and history would indicate it is one...what const[tutes effective tst progress reporting. This list is found in the Test Director’S fuide . 4950 TESTP 80-1, Appcndix H. The second conclusion

  2. Retention indices, relative response factors, and mass spectra of trifluoroacetate esters of phenolic compounds determined by capillary GC/MS: Topical report

    Energy Technology Data Exchange (ETDEWEB)

    Yu, S. K.-T.; Vrana, R. P.; Green, J. B.

    1989-04-01

    GC retention indices on methylsilicone and mass spectra of trifluoroacetyl esters of 118 hydroxyaromatic compounds are reported along with total ion current response factors relative to 4-fluorophenyl trifluoroacetate. Experimental procedures for data acquisition and preparation of trifluoroacetyl esters are provided. This volume represents the most comprehensive tabulation of mass spectra available for this compound type. 8 refs., 8 figs., 5 tabs.

  3. Newly constructed stable reporter cell lines for mechanistic studies on electrophile-responsive element-mediated gene expression reveal a role for flavonoid planarity.

    NARCIS (Netherlands)

    Boerboom, A.M.A.; Vermeulen, M.; Woude, H. van der; Bremer, B.I.; Lee-Hilz, Y.Y.; Kampman, E.; Bladeren, P.J. van; Rietjens, I.M.C.M.; Aarts, J.

    2006-01-01

    The electrophile-responsive element (EpRE) is a transcriptional enhancer involved in cancer-chemoprotective gene expression modulation by certain food components. Two stably transfected luciferase reporter cell lines were developed, EpRE(hNQO1)-LUX and EpRE(mGST-Ya)-LUX, based on EpRE sequences from

  4. Report on the emergency evacuation review team on emergency response plans for the Perry and Davis-Besse nuclear power plants

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    This book is a report by Ohio's Emergency Evacuation Review Team, at the request of Governor Richard Celeste. The Team concludes that the current emergency response plan for Ohio's reactors is inadequate to protect the public and recommends changes in the current emergency plant requirements. The report also includes a summary of the litigation that has occurred since Celeste withdrew his support for the plans, a list of experts consulted, and sources used to prepare the report. An important document, and a study which every state should undertake

  5. Homelessness: The New Hampshire Response. The Final Report and Recommendations of the New Hampshire Task Force on Homelessness.

    Science.gov (United States)

    New Hampshire State Div. of Mental Health and Developmental Services, Concord.

    This report presents results and recommendations of a two-year study and information-gathering effort by the New Hampshire Task Force on Homelessness, in compliance with the charge of the State legislature. The report is comprised of five sections. Section 1, "Introduction," presents an overview of the Task Force and a report on the…

  6. A non-linear association between self-reported negative emotional response to stress and subsequent allostatic load

    DEFF Research Database (Denmark)

    Dich, Nadya; Doan, Stacey N; Kivimäki, Mika

    2014-01-01

    cardiovascular, metabolic and immune function biomarkers at three clinical follow-up examinations. A non-linear association between negative emotional response and allostatic load was observed: being at either extreme end of the distribution of negative emotional response increased the risk of physiological...

  7. Dimensionality of the posttraumatic stress response among police officers and fire fighters: an evaluation of two self-report scales

    NARCIS (Netherlands)

    Witteveen, Anke B.; van der Ploeg, Eleonore; Bramsen, Inge; Huizink, Anja C.; Slottje, Pauline; Smid, Tjabe; van der Ploeg, Henk M.

    2006-01-01

    Confirmatory factor analyses were done to assess the dimensionality of the stress response in a sample of police officers and fire fighters (n = 1,168) involved in the 1992 air disaster in Amsterdam. The confirmatory factor analyses were applied to the responses on two psychometrically different

  8. Practice guideline: Idiopathic normal pressure hydrocephalus: Response to shunting and predictors of response: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.

    Science.gov (United States)

    Halperin, John J; Kurlan, Roger; Schwalb, Jason M; Cusimano, Michael D; Gronseth, Gary; Gloss, David

    2015-12-08

    We evaluated evidence for utility of shunting in idiopathic normal pressure hydrocephalus (iNPH) and for predictors of shunting effectiveness. We identified and classified relevant published studies according to 2004 and 2011 American Academy of Neurology methodology. Of 21 articles, we identified 3 Class I articles. Shunting is possibly effective in iNPH (96% chance subjective improvement, 83% chance improvement on timed walk test at 6 months) (3 Class III). Serious adverse event risk was 11% (1 Class III). Predictors of success included elevated Ro (1 Class I, multiple Class II), impaired cerebral blood flow reactivity to acetazolamide (by SPECT) (1 Class I), and positive response to either external lumbar drainage (1 Class III) or repeated lumbar punctures. Age may not be a prognostic factor (1 Class II). Data are insufficient to judge efficacy of radionuclide cisternography or aqueductal flow measurement by MRI. Clinicians may choose to offer shunting for subjective iNPH symptoms and gait (Level C). Because of significant adverse event risk, risks and benefits should be carefully weighed (Level B). Clinicians should inform patients with iNPH with elevated Ro and their families that they have an increased chance of responding to shunting compared with those without such elevation (Level B). Clinicians may counsel patients with iNPH and their families that (1) positive response to external lumbar drainage or to repeated lumbar punctures increases the chance of response to shunting, and (2) increasing age does not decrease the chance of shunting being successful (both Level C). © 2015 American Academy of Neurology.

  9. Vancouver AIDS conference: special report. The global business response to AIDS: what is a "business-like" response, and is business responding enough?

    Science.gov (United States)

    Whiteside, A

    1996-01-01

    Approximately 40 businesses were represented at a 2-day meeting held immediately before the main Vancouver conference on the Global Business Response to AIDS. Only three companies were from the developing world, with the overwhelming majority being from Canada and the US. Companies in countries where many people are infected with HIV and where the number of AIDS cases is rapidly growing must be concerned about HIV/AIDS. However, in countries of low-level HIV prevalence and infection incidence, businesses may have less concern about HIV/AIDS unless their own employees are infected. Even then, the priority a company gives to coping with the HIV/AIDS pandemic will be determined largely by the importance of the positions of the infected employees. Businesses discussed whether HIV/AIDS merits special attention, the undesirability of screening prospective employees for HIV infection, company size and the ability to respond to the needs of sick employees, the roles of business in society, the general failure of businesses to incorporate HIV/AIDS issues into the mainstream of company operations, how businesses are coping with the HIV/AIDS epidemic, and the need for governments to form a regulatory framework in which businesses can work. Conference participants discussed which steps should be taken next and prepared a declaration for conference organizers, including a mission statement for the global business response to AIDS.

  10. Evaluation of the Validity and Response Burden of Patient Self-Report Measures of the Pain Assessment Screening Tool and Outcomes Registry (PASTOR).

    Science.gov (United States)

    Cook, Karon F; Kallen, Michael A; Buckenmaier, Chester; Flynn, Diane M; Hanling, Steven R; Collins, Teresa S; Joltes, Kristin; Kwon, Kyung; Medina-Torne, Sheila; Nahavandi, Parisa; Suen, Joshua; Gershon, Richard

    2017-07-01

    In 2009, the Army Pain Management Task Force was chartered. On the basis of their findings, the Department of Defense recommended a comprehensive pain management strategy that included development of a standardized pain assessment system that would collect patient-reported outcomes data to inform the patient-provider clinical encounter. The result was the Pain Assessment Screening Tool and Outcomes Registry (PASTOR). The purpose of this study was to assess the validity and response burden of the patient-reported outcome measures in PASTOR. Data for analyses were collected from 681 individuals who completed PASTOR at baseline and follow-up as part of their routine clinical care. The survey tool included self-report measures of pain severity and pain interference (measured using the National Institutes of Health Patient-Reported Outcome Measurement Information System [PROMIS] and the Defense and Veterans Pain Rating scale). PROMIS measures of pain correlates also were administered. Validation analyses included estimation of score associations among measures, comparison of scores of known groups, responsiveness, ceiling and floor effects, and response burden. Results of psychometric testing provided substantial evidence for the validity of PASTOR self-report measures in this population. Expected associations among scores largely supported the concurrent validity of the measures. Scores effectively distinguished among respondents on the basis of their self-reported impressions of general health. PROMIS measures were administered using computer adaptive testing and each, on average, required less than 1 minute to administer. Statistical and graphical analyses demonstrated the responsiveness of PASTOR measures over time. Reprint & Copyright © 2017 Association of Military Surgeons of the U.S.

  11. WAYS OF REPORTING CORPORATE SOCIAL RESPONSABILITY CASE STUDY: THE STATE OF REPORTING OF COMPANIES OPERATING IN THE FIELD OF TEXTILES AND APPAREL

    Directory of Open Access Journals (Sweden)

    ANDREESCU Nicoleta Alina

    2015-05-01

    Full Text Available In this paper we have analysed the current state of reporting CSR activity of companies activating in the textiles and apparel industry. Noticing that the number of companies that invest in CSR programs is increasing on a world-wide level and in the last years even in Romania, we wanted to analyse the situation of the companies from a field of activity less involved in CSR programs. The importance of CSR programs has increased more and more in recent times, from a reputation point of view but mostly of reasons of a stronger involvement of companies in the communities where they are present, but also in educating their own employees which become more motivated if they can participate in various actions undertaken through CSR programs. The implementation of such programs adds value to the businesses developed by the company, taking into account that more segments of consumers have expressed their availability to buy products made by companies that promote such programs. The visibility of CSR projects is made by presenting the programs that the company promotes in sustainability reports, by using means and indicators defined under the Global Reporting Initiative. Following the study we have made, we found out that although world-wide the number of companies that have CSR programs and make sustainability reports is increasing, the number of companies in the textiles and apparel industry that make such reports is very small.

  12. First-year response to rhGH therapy in children with CKD: a National Cooperative Growth Study Report.

    Science.gov (United States)

    Mahan, John D; Warady, Bradley A; Frane, James; Rosenfeld, Ron G; Swinford, Rita D; Lippe, Barbara; Davis, D Aaron

    2010-06-01

    A clear definition of the appropriate growth response during recombinant human growth hormone (rhGH) treatment has never been established in the pediatric chronic kidney disease (CKD) population. We present here data from Genentech's National Cooperative Growth Study (NCGS) on the first-year growth response in prepubertal children with CKD. Using NCGS data, we constructed response curves for the first year of rhGH therapy in 270 (186 males, 84 females) naïve-to-treatment, prepubertal children with CKD prior to transplant or dialysis. Data from both genders were combined because gender was not significantly related to height velocity (p = 0.51). Response to rhGH was expressed as height velocity (HV) in cm/year. Mean, mean + or - 1SD, and mean - 2SD for HV during the first year of rhGH treatment as well as pretreatment HV were plotted versus age. Age-specific HV plots for rhGH-treated children with CKD are presented. At all ages, the first-year mean HV was greater than the mean pretreatment HV. The mean - 2SD for HV in children on rhGH treatment was similar to the mean pretreatment HV. These growth plots will be useful to clinicians for assessing a patient's first-year growth response. We propose that a HV below the mean - 1SD is an inadequate response. These curves may help identify patients with a suboptimal growth response due to confounding medical factors and/or non-compliance.

  13. Effects of Handling and Crowding on the Stress Response and Viability of Chinook Salmon Parr and Smolts, 1984 Completion Report.

    Energy Technology Data Exchange (ETDEWEB)

    Congleton, James L.

    1985-02-01

    Transportation of migrating chinook salmon smolts from Snake River dams to the Columbia River estuary has not reversed a downward trend in Idaho stocks of this species that first became apparent in the late 1960s. Poor survival of transported smolts may be a consequence of physiological responses to stressful events during collection and transportation. This study was undertaken to evaluate the intensity of stress responses in transported smolts, to determine if stress responses decrease the viability of transported smolts, and to investigate ways of avoiding or mitigating stressful events during transportation. 34 refs., 58 figs., 13 tabs.

  14. Complete biochemical (prostate-specific antigen) response to sipuleucel-T with enzalutamide in castration-resistant prostate cancer: a case report with implications for future research.

    Science.gov (United States)

    Graff, Julie N; Drake, Charles G; Beer, Tomasz M

    2013-02-01

    To describe the case of a patient with castration-resistant, metastatic prostate cancer who achieved a complete and durable biochemical response after treatment with sipuleucel-T while continuing with enzalutamide and to explore the immunologic basis for such a response. We obtained serial prostate-specific antigen (PSA) measurements and bone scans to assess the patient's response to enzalutamide followed by the addition of sipuleucel-T. Using preclinical and clinical data, we describe his response through known immunobiologic mechanisms. This patient's PSA level became undetectable during treatment with enzalutamide and began to increase again after 14 months. He opted for treatment with sipuleucel-T, while continuing with the enzalutamide. This resulted in another complete PSA response 6 months after exposure to sipuleucel-T. Sipuleucel-T typically does not produce significant PSA reductions, and, to the best of our knowledge, only 1 previous report of a durable complete PSA response in a patient with metastatic disease has been published. The timing of this response supports an immune mechanism. The biologic rationale for the combination, coupled with the clinical result observed in our patient, provides a basis for studies of the combination of sipuleucel-T and enzalutamide. Published by Elsevier Inc.

  15. Communicating the Corporate Social Responsibility Activities of the UK Division of an International Brewing Company through Sustainability Reporting

    OpenAIRE

    Olayinka, Ogunrinade

    2009-01-01

    Sustainability reporting has risen to prominence in recent years, and has been particularly identified as having the potential to make significant positive contributions to organisational reputation. This project aims to answer the question of how Molson Coors Brewing Company (UK) (MCBC) can best develop its own sustainability reporting in order to enhance the company’s standing both within the alcohol industry and the wider society. In pursuing this aim I draw upon a peer group reporting c...

  16. Role of Cell Cycle Regulation and MLH1, A Key DNA Mismatch Repair Protein, In Adaptive Survival Responses. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    David A. Boothman

    1999-08-11

    Due to several interesting findings on both adaptive survival responses (ASRs) and DNA mismatch repair (MMR), this grant was separated into two discrete Specific Aim sets (each with their own discrete hypotheses). The described experiments were simultaneously performed.

  17. Improving hydrologic disaster forecasting and response for transportation by assimilating and fusing NASA and other data sets : final report.

    Science.gov (United States)

    2017-04-15

    In this 3-year project, the research team developed the Hydrologic Disaster Forecast and Response (HDFR) system, a set of integrated software tools for end users that streamlines hydrologic prediction workflows involving automated retrieval of hetero...

  18. Report to the Nuclear energy Research Advisory Committee (NERAC) Subcommittee on "Long-Term Isotope Research and Productions Plan" - Responses to Questions

    Energy Technology Data Exchange (ETDEWEB)

    Ammoniums

    1999-07-01

    This report presents responses to two series of questions that were raised by a subcommittee of the Nuclear Energy Research Advisory Committee (NERAC) that has been charged with producing a ''Long-Term Isotope Research and Production Plan.'' The NERAC subcommittee is chaired by Dr. Richard Reba, and the Hanford Site Visit team, which comprises a subset of the subcommittee members, is chaired by Dr. Thomas Ruth. The first set of questions raised by the subcommittee on isotope production at the Hanford Site was received from Dr. Ruth on May 10, 1999, and the second set was received from him on July 5, 1999. Responses to the first set of questions were prepared as part of a June 1999 report entitled ''Isotope Production at the Hanford Site in Richland, Washington'' (PNNL 1999a). The responses to these questions are summarized in this document, with frequent references to the June 1999 report for additional details. Responses to the second set of questions from the NERAC subcommittee are presented in this document for the first time.

  19. Corporate social responsibility report 2003. Sharing our energies; Notre energie en partage. TOTAL rapport societal and environnemental 2003

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-05-15

    This document assesses the results of the group Total initiatives in the domain of the corporate social responsibility, for the year 2003. It presents the society policy and actions concerning: the ethics as a foundation of broader corporate, the environment stewardship and the safety enhancement, the equity and diversity of the labor relations and human resources, the broader responsibility to society and communities, the financial performance and a group portrait. (A.L.B.)

  20. Collecting Sensitive Self-Report Data with Laptop Computers: Impact on the Response Tendencies of Adolescents in a Home Interview.

    Science.gov (United States)

    Supple, Andrew J.; Aquilino, William S.; Wright, Debra L.

    1999-01-01

    Explored effects of computerized, self-administered data collection techniques in research on adolescents' self-reported substance use and psychological well-being. Adolescents completing sensitive questions on only laptop computers reported higher levels of substance use and indicated higher levels of depression and irritability; they perceived…

  1. Second response to the recommendations by the Monopolies and Mergers Commission in their report ''United Kingdom Atomic Energy Authority: a Report on the Service Provided by the Authority''

    International Nuclear Information System (INIS)

    1993-06-01

    The Monopolies and Mergers Commission made a series of recommendation about the way AEA Technology should operate. These recommendations are made about the structure and organisation of AEA, its corporate policy, the financial aspects, management, use of assets, industrial relations, pay and employment policies, the efficient use of manpower, investment, pricing, marketing, project management, safety and the quality of goods and services. The response of AEA to each recommendation is given in parallel with the recommendation. Many have already been implemented or are in the process of implementation. (UK)

  2. Evaluation of therapeutic response with 18-FDG PET-CT for non-small cell lung cancer: case report and literature review

    International Nuclear Information System (INIS)

    Bitencourt, Almir G.V.; Lima, Eduardo N.P.; Chojniak, Rubens; Haddad, Fabio J.; Dettino, Aldo L.A.; Cavicchioli, Marcelo; Torres, Ivone C.G.

    2010-01-01

    Positron Emission Tomography / Computed Tomography (PET-CT) is increasingly being used as to complement conventional imaging methods and improve the management of patients with non-small cells lung cancer (NSCLC). The objective of this work is to report on a case in which PET-CT was used as a complementary method to evaluate the therapeutic response in a patient with NSCLC, and to carry out a literature review of the theme. Female patient, 65 years-old, with NSCLC, stage IIIA (T2N2M0), was submitted to exclusive neoadjuvant chemotherapy and presented good response to the treatment, classified by the morphological criteria of the RECIST (Response Evaluation Criteria in Solid Tumors) as a partial response (reduction equal to or greater than 30% in the sum of the widest diameter of all the target lesions in the computed tomography). The metabolic evaluation by PET-CT showed a complete response (reduction equal to or higher than 80% at maximum SUV of the lesions), which was confirmed in the histopathological analysis of the surgical samples. In the case presented, and through the literature review, we show that the evaluation of response with metabolic criteria, associated with morphological criteria, may be more accurate than the use of morphological criteria alone. (author)

  3. Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: A progress report

    International Nuclear Information System (INIS)

    Clewell, Harvey J.; Thomas, Russell S.; Gentry, P. Robinan; Crump, Kenny S.; Kenyon, Elaina M.; El-Masri, Hisham A.; Yager, Janice W.

    2007-01-01

    Cancer risk assessments for inorganic arsenic have been based on human epidemiological data, assuming a linear dose response below the range of observation of tumors. Part of the reason for the continued use of the linear approach in arsenic risk assessments is the lack of an adequate biologically based dose response (BBDR) model that could provide a quantitative basis for an alternative nonlinear approach. This paper describes elements of an ongoing collaborative research effort between the CIIT Centers for Health Research, the U.S. Environmental Protection Agency, ENVIRON International, and EPRI to develop BBDR modeling approaches that could be used to inform a nonlinear cancer dose response assessment for inorganic arsenic. These efforts are focused on: (1) the refinement of physiologically based pharmacokinetic (PBPK) models of the kinetics of inorganic arsenic and its metabolites in the mouse and human; (2) the investigation of mathematical solutions for multi-stage cancer models involving multiple pathways of cell transformation; (3) the review and evaluation of the literature on the dose response for the genomic effects of arsenic; and (4) the collection of data on the dose response for genomic changes in the urinary bladder (a human target tissue for arsenic carcinogenesis) associated with in vivo drinking water exposures in the mouse as well as in vitro exposures of both mouse and human cells. An approach is proposed for conducting a biologically based margin of exposure risk assessment for inorganic arsenic using the in vitro dose response for the expression of genes associated with the obligatory precursor events for arsenic tumorigenesis

  4. Development of an accessibility formulation to measure customers' evaluations of demand-responsive transit (DRT) systems : final report.

    Science.gov (United States)

    2017-03-01

    This report discusses the application of the paratransit microsimulation patron accessibility analysis tool : developed by the University of Texas researchers. The research team worked on updating the DRT Accessibility : Tool developed by the Texas D...

  5. Respuesta del ligamento periodontal a la avulsión dental. Reporte de caso / Periodontal Ligament Response to Dental Avulsion. Case Report

    OpenAIRE

    Solórzano Santos, Raúl; Universidad de Cartagena. Cartagena, Colombia; Díaz-Caballero, Antonio José; Universidad de Cartagena. Cartagena, Colombia; Covo Morales, Eduardo; Universidad de Cartagena, Cartagena, Colombia

    2017-01-01

    RESUMEN. Antecedentes: La avulsión es un tipo de lesión traumática poco frecuente en la dentición permanente. La reabsorción radicular externa es un evento común posterior al reimplante de un diente avulsionado. Objetivo: Reportar un caso de trauma de dos dientes reimplantados, en el que se obtuvieron resultados satisfactorios con 26 semanas de seguimiento. Reporte del caso: Manejo clínico de paciente de sexo masculino de 8 años de edad que se presenta a la clínica del Postgrado de Endodoncia...

  6. Combat-related posttraumatic stress disorder and criminal responsibility determinations in the post-iraq era: a review and case report.

    Science.gov (United States)

    Frierson, Richard L

    2013-01-01

    Since 2002, hundreds of thousands of United States troops have returned from the Iraq and Afghanistan theaters, many after multiple deployments. The high suicide rate and high prevalence of mood disorders, substance use disorders, and posttraumatic stress disorder (PTSD) in this population have been widely reported. Many returning soldiers have had difficulty adjusting to civilian life, and some have incurred legal charges. In this article, I review the prevalence and legal implications of combat-related PTSD in this population, including how symptoms of PTSD may be relevant in criminal responsibility determinations in jurisdictions that use a M'Naughten standard or American Law Institute (ALI) Model Penal Code test for criminal responsibility. Finally, an actual case in which a criminal defendant was found to lack criminal responsibility in a M'Naughten jurisdiction because of PTSD symptoms at the time of the alleged offense will be presented.

  7. Impaired response inhibition is associated with self-reported symptoms of depression, anxiety, and ADHD in female FMR1 premutation carriers.

    Science.gov (United States)

    Kraan, Claudine M; Hocking, Darren R; Georgiou-Karistianis, Nellie; Metcalfe, Sylvia A; Archibald, Alison D; Fielding, Joanne; Trollor, Julian; Bradshaw, John L; Cohen, Jonathan; Cornish, Kim M

    2014-01-01

    Fragile X Mental Retardation 1 (FMR1) premutation carriers (PM-carriers) have a defective trinucleotide expansion on the FMR1 gene that is associated with continuum of neuropsychological and mental disorders. Currently, little is known about the distinct subcomponents of executive function potentially impaired in female PM-carriers, and there have been no investigations into associations between executive function and incidences of mental disorders. A total of 35 female PM-carriers confirmed by Asuragen triple primed PCR DNA testing and 35 age- and intelligence-matched controls completed tests of executive function (i.e., response inhibition and working memory) and self-reported on social anxiety, depression, and ADHD predominantly inattentive (ADHD-PI) symptoms. Compared to controls, PM-carriers were significantly elevated on self-reported social anxiety and ADHD-PI symptoms. Irrespective of mental symptoms, female PM-carries performed significantly worse than controls on a response inhibition test, and further investigations revealed significant correlations between executive function performance and self-reported symptoms of anxiety, depression and ADHD-PI. Critically, among PM-carriers with good executive function performance, no women exceeded threshold markers for probable caseness of mental disorder. However, rates of probable caseness were elevated in those with average performance (response inhibition: social anxiety: 41.7%; depression: 20%; ADHD: 44.4%; working memory: social anxiety: 27.3%; depression: 9.1%; ADHD: 18.2%) and highly elevated for those with poor executive function performance (response inhibition: social anxiety: 58.3%; depression: 80%; ADHD: 55.6%; working memory: social anxiety: 100%; depression: 50%; ADHD: 83.3%). These data suggest that subtle executive dysfunction may be a useful neuropsychological indicator for a range of mental disorders previously reported in female PM-carriers. © 2013 Wiley Periodicals, Inc.

  8. Piracetam-induced changes on the brainstem auditory response in anesthetized juvenile rhesus monkeys (Macaca mulatta). Report of two clinical cases.

    Science.gov (United States)

    Durand-Rivera, A; Gonzalez-Pina, R; Hernandez-Godinez, B; Ibanez-Contreras, A; Bueno-Nava, A; Alfaro-Rodriguez, A

    2012-10-01

    We describe two clinical cases and examine the effects of piracetam on the brainstem auditory response in infantile female rhesus monkeys (Macaca mulatta). We found that the interwave intervals show a greater reduction in a 3-year-old rhesus monkey compared to a 1-year-old rhesus monkey. In this report, we discuss the significance of these observations. © 2012 John Wiley & Sons A/S.

  9. European Academy of Allergy and Clinical Immunology task force report on 'dose-response relationship in allergen-specific immunotherapy'

    DEFF Research Database (Denmark)

    Calderón, M A; Larenas, D; Kleine-Tebbe, J

    2011-01-01

    For a century, allergen-specific immunotherapy (SIT) has proven to be an effective treatment for allergic rhinitis, asthma, and insect sting allergy. However, as allergen doses are frequently adapted to the individual patient, there are few data on dose-response relationship in SIT. Allergen prod...

  10. Academic Advising for Student Success: A System of Shared Responsibility. ASHE-ERIC Higher Education Report No. 3, 1991.

    Science.gov (United States)

    Frost, Susan H.

    This monograph examines student advising in the higher education setting by focusing on shared responsibility strategies that enhance student motivation and persistence in a diverse student population. In the first two sections, a new concept of advising called developmental advising is described in which the relationship between advisor and…

  11. Differential predictive power of self report and implicit measures on behavioural and physiological fear responses to spiders

    NARCIS (Netherlands)

    van Bockstaele, B.; Verschuere, B.; Koster, E.H.W.; Tibboel, H.; de Houwer, J.; Crombez, G.

    2011-01-01

    In this study, we investigated to what extent indirect measures predict behavioural and physiological fear responses towards spiders. Implicit attitudes towards spiders were assessed using an implicit association test and attentional bias towards spiders was assessed using a dot probe task and a

  12. Dimensionality of the posttraumatic stress response among police officers and fire fighters: an evaluation of two self-report scales.

    Science.gov (United States)

    Witteveen, Anke B; Van der Ploeg, Eleonore; Bramsen, Inge; Huizink, Anja C; Slottje, Pauline; Smid, Tjabe; Van der Ploeg, Henk M

    2006-02-28

    Confirmatory factor analyses were done to assess the dimensionality of the stress response in a sample of police officers and fire fighters (n = 1,168) involved in the 1992 air disaster in Amsterdam. The confirmatory factor analyses were applied to the responses on two psychometrically different instruments, i.e., the Self-Rating Inventory for Posttraumatic Stress Disorder (SRIP) and the Impact of Event Scale (IES). The previously found distinction between (active) avoidance and numbing in samples highly affected by posttraumatic stress disorder appears to be applicable to the stress response of a less affected sample. For the SRIP, a five-factor structure (i.e., intrusion, avoidance, hyperarousal, emotional numbing and sleep disturbance) appeared to fit slightly better than the four-factor structures from previous findings. For the IES, our results replicated findings of a four-dimensional structure (i.e., intrusion, avoidance, numbing and sleep disturbance) underlying the posttraumatic stress response. The factors of the best-fitting structure of both instruments proved reliable. Due to the psychometric properties of the two instruments, the relationship between similar factors in both instruments was only low to moderate. Compared with the IES, factors of the SRIP were, however, less discriminative from other symptoms of psychopathology. Replication in different traumatized or community samples is recommended.

  13. The relation between continuous and discrete emotional responses to food odors with facial expressions and non-verbal reports

    NARCIS (Netherlands)

    He, W.; Boesveldt, S.; Graaf, de C.; Wijk, de R.A.

    2016-01-01

    Traditional sensory and hedonic tests are often limited to predict market performance. Investigating emotional responses to food stimuli may contribute to a better understanding of consumers’ eating behavior. In the present study, 26 female participants were exposed to an orange (pleasant) and a

  14. The Relationship of Student Involvement in Political Organizations to Self-Reported Capacities for Socially Responsible Leadership

    Science.gov (United States)

    Hogendorp, Melanie Beth

    2012-01-01

    This research investigated the relationship between college students' political involvement and their capacities for socially responsible leadership, including which student characteristics, precollege experiences, and collegiate experiences contributed to these capacities. Political involvement was defined as participation in co-curricular,…

  15. Constructed-Response DIF Evaluations for Mixed-Format Tests. Research Report. ETS RR-13-33

    Science.gov (United States)

    Moses, Tim; Liu, Jinghua; Tan, Adele; Deng, Weiling; Dorans, Neil J.

    2013-01-01

    In this study, differential item functioning (DIF) methods utilizing 14 different matching variables were applied to assess DIF in the constructed-response (CR) items from 6 forms of 3 mixed-format tests. Results suggested that the methods might produce distinct patterns of DIF results for different tests and testing programs, in that the DIF…

  16. Privileged Communication--Rights and Responsibilities of College Counselors Under Wisconsin Law. Volume 4, Number 6. Counseling Center Reports.

    Science.gov (United States)

    Nolting, Earl; Leege, William

    Selected legal responsibilities of counselors under the present laws of the State of Wisconsin are reviewed. Specifically, statutes concerning privileged communication and confidentiality, drug abuse and abortion are printed in full or in part, and major questions and basic legal principles relevant to them are examined as they pertain to the…

  17. Increased intracranial pressure and cardiac arrest after heart transplantation. What about the Cushing response in a denervated heart? Case report.

    Science.gov (United States)

    Moskopp, D; Kehl, G; Horch, C; Puskás, Z; Wassmann, H; Schuierer, G; Fingerhut, D

    1994-01-01

    A 13-year-old boy suffered cerebrovascular complications after heart transplantation (ischemic mass effect in the posterior cranial fossa). He had to be resuscitated from cardiac arrest with coma. After a modified cerebellar hemispherectomy the course was favorable.--The most conclusive explanation for the acute event is that a Cushing response was preserved even in the presumably denervated heart.

  18. Measuring fatigue in patients with multiple sclerosis: reproducibility, responsiveness and concurrent validity of three Dutch self-report questionnaires

    NARCIS (Netherlands)

    Rietberg, M.B.; van Wegen, E.E.H.; Kwakkel, G.

    2010-01-01

    Purpose.To determine the reproducibility, responsiveness and concurrent validity of Dutch versions of the Fatigue Severity Scale (FSS), Modified Fatigue Impact Scale (MFIS), and Checklist Individual Strength (CIS20R) in patients with multiple sclerosis (MS). Method.Forthy-three ambulatory patients

  19. Opportunities for Open Automated Demand Response in Wastewater Treatment Facilities in California - Phase II Report. San Luis Rey Wastewater Treatment Plant Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Lisa; Lekov, Alex; McKane, Aimee; Piette, Mary Ann

    2010-08-20

    This case study enhances the understanding of open automated demand response opportunities in municipal wastewater treatment facilities. The report summarizes the findings of a 100 day submetering project at the San Luis Rey Wastewater Treatment Plant, a municipal wastewater treatment facility in Oceanside, California. The report reveals that key energy-intensive equipment such as pumps and centrifuges can be targeted for large load reductions. Demand response tests on the effluent pumps resulted a 300 kW load reduction and tests on centrifuges resulted in a 40 kW load reduction. Although tests on the facility?s blowers resulted in peak period load reductions of 78 kW sharp, short-lived increases in the turbidity of the wastewater effluent were experienced within 24 hours of the test. The results of these tests, which were conducted on blowers without variable speed drive capability, would not be acceptable and warrant further study. This study finds that wastewater treatment facilities have significant open automated demand response potential. However, limiting factors to implementing demand response are the reaction of effluent turbidity to reduced aeration load, along with the cogeneration capabilities of municipal facilities, including existing power purchase agreements and utility receptiveness to purchasing electricity from cogeneration facilities.

  20. Production of Short-Rotation Woody Crops Grown with a Range of Nutrient and Water Availability: Establishment Report and First-Year Responses

    Energy Technology Data Exchange (ETDEWEB)

    D.R. Coyle; J. Blake; K. Britton; M.; R.G. Campbell; J. Cox; B. Cregg; D. Daniels; M. Jacobson; K. Johnsen; T. McDonald; K. McLeod; E.; D. Robison; R. Rummer; F. Sanchez; J.; B. Stokes; C. Trettin; J. Tuskan; L. Wright; S. Wullschleger

    2003-12-31

    Coleman, M.D., et. al. 2003. Production of Short-Rotation Woody Crops Grown with a Range of Nutrient and Water Availability: Establishment Report and First-Year Responses. Report. USDA Forest Service, Savannah River, Aiken, SC. 26 pp. Abstract: Many researchers have studied the productivity potential of intensively managed forest plantations. However, we need to learn more about the effects of fundamental growth processes on forest productivity; especially the influence of aboveground and belowground resource acquisition and allocation. This report presents installation, establishment, and first-year results of four tree species (two cottonwood clones, sycamore, sweetgum, and loblolly pine) grown with fertilizer and irrigation treatments. At this early stage of development, irrigation and fertilization were additive only in cottonwood clone ST66 and sweetgum. Leaf area development was directly related to stem growth, but root production was not always consistent with shoot responses, suggesting that allocation of resources varies among treatments. We will evaluate the consequences of these early responses on resource availability in subsequent growing seasons. This information will be used to: (1) optimize fiber and bioenergy production; (2) understand carbon sequestration; and (3) develop innovative applications such as phytoremediation; municipal, industrial, and agricultural wastes management; and protection of soil, air, and water resources.

  1. Self-Reported Mindful Attention and Awareness, Go/No-Go Response-Time Variability, and Attention-Deficit Hyperactivity Disorder.

    Science.gov (United States)

    Keith, Julian R; Blackwood, Mallory E; Mathew, Rano T; Lecci, Len B

    2017-06-01

    The abilities to stabilize the focus of attention, notice attention lapses, and return attention to an intended object following lapses are precursors for mindfulness. Individuals diagnosed with attention-deficit hyperactivity disorder (ADHD) are deficient in the attentional and self-control skills that characterize mindfulness. The present study assessed the relationship between mindfulness and ADHD in young adults using the Mindful Attention and Awareness Scale (MAAS), a computerized Go/No-Go task (the Test of Variables of Attention (TOVA)), the World Health Organization Adult Self-Report Scale (ASRS), a tool used as an adult ADHD screen, the Beck Anxiety Inventory (BAI), and the Beck Depression Inventory-II (BDI-II). We recruited 151 adult volunteers (ages 18 to 40); 100 with confirmed ADHD diagnoses and 51 control participants. Overall, participants with prior diagnoses of ADHD scored lower on the MAAS than controls and ASRS scores were strongly negatively correlated MAAS scores. Attention performance index, response time, and response-time variability subscales of the TOVA were positively correlated with MAAS scores and negatively correlated with ASRS scores. Intrasubject response-time variability on the TOVA, a parameter associated with attention lapses, was also strongly negatively correlated with MAAS scores. Overall, participants' self-reported mindfulness, as measured by the MAAS, was strongly related to self-reports on a clinical measure of attention disorders, anxiety, depression, and multiple indices of concentration and mind wandering on a standardized Go/No-Go task, the TOVA.

  2. Risk reporting in the Chinese news media in response to radiation threat from the Fukushima nuclear reactor crisis

    International Nuclear Information System (INIS)

    Wen Wang

    2013-01-01

    On March 11, 2011, the northeastern coast of Japan was struck by 9.0-magnitude earthquake that triggered a devastating tsunami. Aside from the huge toll in people's lives and severe damages to property, the tremor sent the Fukushima Daiichi Nuclear Power Plant on a tailspin, causing hydrogen explosions in three reactors, and sending radioactive materials into the air and bodies of water. Declared the largest nuclear disaster since Chernobyl, the crisis threatened neighboring countries, including China (International Business Times, 2011). On March 28, low levels of iodine-131, cesium-137 and strontium, believed to have drifted from Japan, were detected in the air over Heilongjiang province in the northeast part of China and in seawater samples collected in the eastern coastal areas (Qianjiang Eve News, 2011). Because these chemicals can enter the food chain and adversely affect human health (Ifeng.com, 2011), people became understandably anxious and the government had to avert panic. This study asks: How did the Chinese media report the risks attendant to this event? A content analysis of 45 straight news reports published by the Chinese press from March 16, 2011 to April 25, 2011 was conducted. The analysis focused on how the media explained the risk, portrayed potential harm, reported on government actions to safeguard public health, and provided suggestions to reduce public fear. The sources of information cited in the reports were also identified. The articles examined were collected from People.com, a comprehensive online archive of news reports, using 'Fukushima' and 'nuclear radiation' as search terms. The results indicated journalistic practices that left much to be desired in terms of risk reporting. First, the articles explained little about the technical aspects of the radiation leaks and failed to give audiences a general indication of levels of risk. Second, the media over-emphasized the government's position that the

  3. Risk reporting in the Chinese news media in response to radiation threat from the Fukushima nuclear reactor crisis

    Energy Technology Data Exchange (ETDEWEB)

    Wen Wang [Greenlee School of Journalism and Communication, Iowa State University, Ames, Iowa (United States)

    2013-07-01

    On March 11, 2011, the northeastern coast of Japan was struck by 9.0-magnitude earthquake that triggered a devastating tsunami. Aside from the huge toll in people's lives and severe damages to property, the tremor sent the Fukushima Daiichi Nuclear Power Plant on a tailspin, causing hydrogen explosions in three reactors, and sending radioactive materials into the air and bodies of water. Declared the largest nuclear disaster since Chernobyl, the crisis threatened neighboring countries, including China (International Business Times, 2011). On March 28, low levels of iodine-131, cesium-137 and strontium, believed to have drifted from Japan, were detected in the air over Heilongjiang province in the northeast part of China and in seawater samples collected in the eastern coastal areas (Qianjiang Eve News, 2011). Because these chemicals can enter the food chain and adversely affect human health (Ifeng.com, 2011), people became understandably anxious and the government had to avert panic. This study asks: How did the Chinese media report the risks attendant to this event? A content analysis of 45 straight news reports published by the Chinese press from March 16, 2011 to April 25, 2011 was conducted. The analysis focused on how the media explained the risk, portrayed potential harm, reported on government actions to safeguard public health, and provided suggestions to reduce public fear. The sources of information cited in the reports were also identified. The articles examined were collected from People.com, a comprehensive online archive of news reports, using 'Fukushima' and 'nuclear radiation' as search terms. The results indicated journalistic practices that left much to be desired in terms of risk reporting. First, the articles explained little about the technical aspects of the radiation leaks and failed to give audiences a general indication of levels of risk. Second, the media over-emphasized the government's position that the

  4. Special issue on"social responsibility accounting and reporting in times of ‘sustainability Downturn/crisis

    Directory of Open Access Journals (Sweden)

    Carmen Correa-ruiz

    2011-08-01

    Full Text Available At a time when sustainability performance does not seem to match the expectations raised by the sustainable development concept and, moreover, when the economic downturn and crisis could be further eroding social and environmental concerns and values, the notion of sustainability crisis provides an interesting starting point to reflect on the role of Social and Environmental Accounting Research. Lack of humanity and values, short term economic approach, institutional capture and misunderstanding and misuse of democracy, have all served as catalysts of sustainability downturn and crisis. Thus, this editorial attempts to advance public interest accounting by discussing the controversy around Sustainability and Corporate Social Responsibility, expecting that the constitutive effects of researchers’ words in this special issue and in future research agendas, will result in more transformative power relations able to enhance a healthy democracy inspired by the capacity to do things and to transform individuals’ attitudes and behaviours, as well as the institutional response to the sustainability crisis.

  5. Criteria for preparation and evaluation of radiological emergency response plans and preparedness in support of nuclear power plants. Interim report

    International Nuclear Information System (INIS)

    1980-01-01

    The purpose of this document is to provide a common reference and interim guidance source for: state and local governments and nuclear facility operators in the development of radiological emergency response plans and preparedness in support of nuclear power plants; and Nuclear Regulatory Commission (NRC), Federal Emergency Management Agency (FEMA) and other Federal agency personnel engaged in the review of state, local government, and licensee plans and preparedness

  6. Repair and cell cycle response in cells exposed to environmental biohazards. Final report, January 1, 1973-December 31, 1984

    International Nuclear Information System (INIS)

    Hadden, C.T.; Billen, D.

    1986-01-01

    These studies have focussed on agents which cause damage to DNA leading to inhibition of DNA synthesis or faulty DNA replication or repair. The overall goal of this project has been to understand how environmental agents interact with the DNA of cells and how cells cope with any resulting damage. In particular we have been concerned with the nature of the repair systems involved in restoration of damaged DNA and the cellular responses to radiation or chemical damage

  7. Advanced Epithelioid Malignant Peripheral Nerve Sheath Tumor Showing Complete Response to Combined Surgery and Chemotherapy: A Case Report

    Directory of Open Access Journals (Sweden)

    Tomohiro Minagawa

    2011-01-01

    We describe a case of a 62-year-old male with an epithelioid MPNST of the left foot. Multiple lung metastases developed after radical surgery on the primary lesion. The response to adjuvant chemotherapy including doxorubicin and ifosfamide was favorable, and thoracoscopic resection was subsequently performed on the remaining three metastases. No evidence of recurrence or metastasis was observed at the 12-month followup after the first operation. Further followup and chemotherapy may be required.

  8. The Impact of Two Different Transfusion Strategies on Patient Immune Response during Major Abdominal Surgery: A Preliminary Report

    OpenAIRE

    Theodoraki, Kassiani; Markatou, Maria; Rizos, Demetrios; Fassoulaki, Argyro

    2014-01-01

    Blood transfusion is associated with well-known risks. We investigated the difference between a restrictive versus a liberal transfusion strategy on the immune response, as expressed by the production of inflammatory mediators, in patients subjected to major abdominal surgery procedures. Fifty-eight patients undergoing major abdominal surgery were randomized preoperatively to either a restrictive transfusion protocol or a liberal transfusion protocol (with transfusion if hemoglobin dropped be...

  9. Behavioral Responses Of Fish To A Current-Based Hydrokinetic Turbine Under Mutlipe Operational Conditions: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Grippo, Mark A. [Argonne National Lab. (ANL), Argonne, IL (United States); Shen, Haixue [Univ. of Maine, Orono, ME (United States); Zydlewski, Gayle [Univ. of Maine, Orono, ME (United States); Rao, Shivanesh [Univ. of Maine, Orono, ME (United States); Goodwin, Andy [United States Army Engineer R & D Center, Vicksburg, MI (United States)

    2017-02-01

    There is significant interest in the interaction of aquatic organisms with current-based marine and hydrokinetic (MHK) technologies. Determining the potential impacts of MHK devices on fish behavior is critical to addressing the environmental concerns that could act as barriers to the permitting and deployment of MHK devices. To address these concerns, we use field monitoring and fish behavior models to characterize the behavioral responses of fish to MHK turbines and infer potential stimuli that may have elicited the observed behavioral changes.

  10. Final technical report. Can microbial functional traits predict the response and resilience of decomposition to global change?

    Energy Technology Data Exchange (ETDEWEB)

    Allison, Steven D. [Univ. of California, Irvine, CA (United States)

    2015-09-24

    The role of specific micro-organisms in the carbon cycle, and their responses to environmental change, are unknown in most ecosystems. This knowledge gap limits scientists’ ability to predict how important ecosystem processes, like soil carbon storage and loss, will change with climate and other environmental factors. The investigators addressed this knowledge gap by transplanting microbial communities from different environments into new environments and measuring the response of community composition and carbon cycling over time. Using state-of-the-art sequencing techniques, computational tools, and nanotechnology, the investigators showed that microbial communities on decomposing plant material shift dramatically with natural and experimentally-imposed drought. Microbial communities also shifted in response to added nitrogen, but the effects were smaller. These changes had implications for carbon cycling, with lower rates of carbon loss under drought conditions, and changes in the efficiency of decomposition with nitrogen addition. Even when transplanted into the same conditions, microbial communities from different environments remained distinct in composition and functioning for up to one year. Changes in functioning were related to differences in enzyme gene content across different microbial groups. Computational approaches developed for this project allowed the conclusions to be tested more broadly in other ecosystems, and new computer models will facilitate the prediction of microbial traits and functioning across environments. The data and models resulting from this project benefit the public by improving the ability to predict how microbial communities and carbon cycling functions respond to climate change, nutrient enrichment, and other large-scale environmental changes.

  11. Repair and cell cycle response in cells exposed to environmental biohazards. Progress report, February 1, 1976--May 31, 1977

    International Nuclear Information System (INIS)

    Billen, D.

    1977-01-01

    Progress is reported on the following research projects: DNA polymerase III dependent repair of x-ray damage in Escherichia coli; regulation of reinsertation of nucleotides by DNA ligase; DNA synthesis in permeabilized CHO cells; measurement of damage to DNA in Bacillus subtilis; repair defect in rec A cells; inactivation of transforming DNA; and mutagenesis of transforming DNA

  12. 34 CFR 611.47 - What are a scholarship recipient's reporting responsibilities upon the close of the LEA's...

    Science.gov (United States)

    2010-07-01

    ... may require, that confirms that the recipient has taught during this period in a high-need school... 34 Education 3 2010-07-01 2010-07-01 false What are a scholarship recipient's reporting... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Scholarships § 611.47 What are a scholarship recipient...

  13. Preliminary Investigation of Self-Reported Emotional Responses to Approaching and Receding Footstep Sounds in a Virtual Reality Context

    DEFF Research Database (Denmark)

    Sikström, Erik; Nilsson, Niels Christian; Nordahl, Rolf

    2013-01-01

    virtual reality using a head-mounted display, 24-channel surround audio and a novel walking-in-place device utilizing acoustic detection of the user's input. Based on self-reports using the Self-Assessment Manikin, the subjects gave post-experiment evaluations of 7 seconds long footstep sequence...

  14. Repair and cell cycle response in cells exposed to environmental biohazards. Progress report, June 1, 1979-May 31, 1980

    International Nuclear Information System (INIS)

    Billen, D.; Hadden, C.T.

    1980-01-01

    Progress is reported in the following research areas: (1) DNA repair in Bacillus subtilis; (2) postreplication repair in Rec - mutants of B. subtilis; (3) photobiology of halogenated DNA; (4) effects of caffeine on pyrimidine dimer excision and postreplication repair in B. subtilis; and (5) DNA repair in toluene-treated Escherichia coli

  15. Associations between a history of binge drinking during adolescence and self-reported responses to alcohol in young adult Native and Mexican Americans.

    Science.gov (United States)

    Ehlers, Cindy L; Stouffer, Gina M; Gilder, David A

    2014-07-01

    Binge drinking during adolescence is common and may predict increased drinking in young adulthood and enhanced risk of alcohol dependence. Variation in level of response to the hedonic and adverse effects of alcohol is in part an inherited factor that may also influence its use, abuse, and dependence. This study investigated, in young adults, whether an association could be demonstrated between variation in self-reported responses to alcohol and a history of binge drinking during adolescence. Young adult (18 to 30 years, n = 790) Native Americans and Mexican Americans were recruited from the community and completed a structured diagnostic interview. Response to alcohol was indexed using the expectation version of the Subjective High Assessment Scale (SHAS-E). An adolescent history of regular binge drinking was defined as drinking 5 or more drinks for boys and 4 or more drinks for girls per drinking occasion at least once a month during their highest drinking period prior to the age of 18. An adolescent history of regular binge drinking was found to be associated with a lower level of self-reported responses to the negative aspects of alcohol intoxication (feeling terrible) as well as to the overall level of intoxication, but not to the positive impressions of intoxication (feeling great) on the SHAS-E. A history of regular adolescent binge drinking was also correlated with less feelings of the "terrible" and "total" effects of alcohol, as indexed by the SHAS-E, in a linear regression model that included several diagnostic and demographic variables such as a history of conduct disorder and current levels of drinking. These data suggest that a history of adolescent binge drinking is associated with a reduction in the self-reported level of intoxication in young adulthood, a factor that could theoretically lead to increased risk of alcohol dependence. Copyright © 2014 by the Research Society on Alcoholism.

  16. Comparison of Self-Reported Telephone Interviewing and Web-Based Survey Responses: Findings From the Second Australian Young and Well National Survey.

    Science.gov (United States)

    Milton, Alyssa C; Ellis, Louise A; Davenport, Tracey A; Burns, Jane M; Hickie, Ian B

    2017-09-26

    Web-based self-report surveying has increased in popularity, as it can rapidly yield large samples at a low cost. Despite this increase in popularity, in the area of youth mental health, there is a distinct lack of research comparing the results of Web-based self-report surveys with the more traditional and widely accepted computer-assisted telephone interviewing (CATI). The Second Australian Young and Well National Survey 2014 sought to compare differences in respondent response patterns using matched items on CATI versus a Web-based self-report survey. The aim of this study was to examine whether responses varied as a result of item sensitivity, that is, the item's susceptibility to exaggeration on underreporting and to assess whether certain subgroups demonstrated this effect to a greater extent. A subsample of young people aged 16 to 25 years (N=101), recruited through the Second Australian Young and Well National Survey 2014, completed the identical items on two occasions: via CATI and via Web-based self-report survey. Respondents also rated perceived item sensitivity. When comparing CATI with the Web-based self-report survey, a Wilcoxon signed-rank analysis showed that respondents answered 14 of the 42 matched items in a significantly different way. Significant variation in responses (CATI vs Web-based) was more frequent if the item was also rated by the respondents as highly sensitive in nature. Specifically, 63% (5/8) of the high sensitivity items, 43% (3/7) of the neutral sensitivity items, and 0% (0/4) of the low sensitivity items were answered in a significantly different manner by respondents when comparing their matched CATI and Web-based question responses. The items that were perceived as highly sensitive by respondents and demonstrated response variability included the following: sexting activities, body image concerns, experience of diagnosis, and suicidal ideation. For high sensitivity items, a regression analysis showed respondents who were male

  17. Recommendations for the standardization of bone marrow disease assessment and reporting in children with neuroblastoma on behalf of the International Neuroblastoma Response Criteria Bone Marrow Working Group.

    Science.gov (United States)

    Burchill, Susan A; Beiske, Klaus; Shimada, Hiroyuki; Ambros, Peter F; Seeger, Robert; Tytgat, Godelieve A M; Brock, Penelope R; Haber, Michelle; Park, Julie R; Berthold, Frank

    2017-04-01

    The current study was conducted to expedite international standardized reporting of bone marrow disease in children with neuroblastoma and to improve equivalence of care. A multidisciplinary International Neuroblastoma Response Criteria Bone Marrow Working Group was convened by the US National Cancer Institute in January 2012 with representation from Europe, North America, and Australia. Practical transferable recommendations to standardize the reporting of bone marrow disease were developed. To the authors' knowledge, the current study is the first to comprehensively present consensus criteria for the collection, analysis, and reporting of the percentage area of bone marrow parenchyma occupied by tumor cells in trephine-biopsies. The quantitative analysis of neuroblastoma content in bone marrow aspirates by immunocytology and reverse transcriptase-quantitative polymerase chain reaction are revised. The inclusion of paired-like homeobox 2b (PHOX2B) for immunohistochemistry and reverse transcriptase-quantitative polymerase chain reaction is recommended. Recommendations for recording bone marrow response are provided. The authors endorse the quantitative assessment of neuroblastoma cell content in bilateral core needle biopsies-trephines and aspirates in all children with neuroblastoma, with the exception of infants, in whom the evaluation of aspirates alone is advised. It is interesting to note that 5% disease is accepted as an internationally achievable level for disease assessment. The quantitative assessment of neuroblastoma cells is recommended to provide data from which evidence-based numerical criteria for the reporting of bone marrow response can be realized. This is particularly important in the minimal disease setting and when neuroblastoma detection in bone marrow is intermittent, where clinical impact has yet to be validated. The wide adoption of these harmonized criteria will enhance the ability to compare outcomes from different trials and facilitate

  18. Phase II investigation of the response of columns to short duration loadings: scaling report. Mark I Program, Task 3.2.1. Teledyne report TR-2488(e)

    International Nuclear Information System (INIS)

    1978-03-01

    Phase II of a two-phase column testing program which will determine short-term load capacities for the Mark I containment columns is now under way. The scaling report is submitted to outline the scaling procedures and also to present the scaled quantities such as geometry, load eccentricity, and load time duration. Dimensional analysis and similarity techniques were applied to the experimental models to obtain a set of twelve scaling laws. These scaling laws provide a rational basis for modeling the columns. The scaling laws give nondimensional relationships which are common to both the model and prototype. Parameters which are known to be important in column buckling and which were found to be important during Phase I testing were used as the independent variables in the scaling laws. Column specimens for Phase II testing have been designed to be representative of the prototype columns. Combined bending and compression are characteristic of the Mark I columns with the maximum moment applied at the column-ring girder junction. The experimental columns reflect these characteristics, even though special fixtures and equipment will be required to perform the tests. The column specimens include the scaled rotational stiffness of the ring girder as well as the boundary condition of the pinned or sliding end. To properly incorporate the effects of residual stress, the models will be constructed from ''off-the-shelf', carbon steel pipe and rolled sections, and built-up sections will be fabricated from standard plate. The column geometries scale almost exactly, even though ''replica'' modeling was not used

  19. Comparability of Structured Interview of Reported Symptoms (SIRS) and Structured Interview of Reported Symptoms-Second Edition (SIRS-2) Classifications With External Response Bias Criteria.

    Science.gov (United States)

    Tylicki, Jessica L; Wygant, Dustin B; Tarescavage, Anthony M; Frederick, Richard I; Tyner, Elizabeth A; Granacher, Robert P; Sellbom, Martin

    2018-02-01

    Rogers, Sewell, and Gillard (2010) released a revised version of the Structured Interview of Reported Symptoms (SIRS; Rogers, Bagby, & Dickens, 1992), the SIRS-2, which introduced several new scales, indices, and a new classification model with the overall goal of improving its classification of genuine versus feigned presentations. Since the release of the SIRS-2, several concerns have been raised regarding the quality of the SIRS-2 development and validation samples and the method used to calculate classification accuracy estimates. To further explore issues related to the clinical utility of the SIRS-2, the current study examined associations of the SIRS and SIRS-2 with the Minnesota Multiphasic Personality Inventory-2-Restructured Form (Ben-Porath & Tellegen, 2008/2011) validity scales in separate samples of disability claimants and criminal defendants. Results indicate that the SIRS-2 reduced the number of feigning classifications. Additional analyses suggest that the Modified Total Index and Supplementary Scale Index do not assess the test-taking strategy that Rogers and colleagues (2010) intended the indices to capture. External data indicates that evaluees reclassified on the SIRS-2 in nonfeigning categories exhibited feigned symptoms of psychopathology. Indeed, we found that SIRS-identified feigners showed significant evidence of overreporting on the Minnesota Multiphasic Personality Inventory-2-Restructured Form validity scales, regardless of their SIRS-2 classification. The current study highlights the overall weakness in clinical utility of the SIRS-2. Implications of these results for both clinical and forensic settings are discussed. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  20. Hyperfractionated Radiotherapy and Concurrent Chemotherapy for Stage III Unascertainable Non Small Cell Lung Cancer : Preliminary Report for Response and Toxicity

    International Nuclear Information System (INIS)

    Choi, Eun Kyung; Kim, Jong Hoon; Chang, Hye Sook

    1995-01-01

    Lung cancer study group at Asan Medical Center has conducted the second prospective study to determine the efficacy and feasibility of MVP chemotherapy with concurrent hyperfractionated radiotherapy for patients with stage III unresectable non-small cell lung cancer(NSCLC). All eligible patients with stage III unresectable NSCLC were treated with hyperfractionated radiotherapy( 120 cGy/fx BID, 6480 cGY/54fx) and concurrent 2 cycles of MVP(Motomycin C 6 mg/m 2 , d2 and d29, Vinblastin 6 mg/m 2 , d2 and d29, Cisplatin 6 mg/m 2 , d1 and d28) chemotherapy. Between Aug. 1993 and Nov. 1994, 62 patients entered this study ; 6(10%) had advanced stage IIIa and 56(90%) had IIIb disease including 1 with pleural effusion and 10 with supraclavicular metastases. Among 62 Patients, 48(77%) completed planned therapy. Fourteen patients refused further treatment during chemoradiotherapy. Of 46 patients evaluable for response, 34(74%) showed major response including 10(22%) with complete and 24(52%) with partial responses. Of 48 patients evaluable for toxicity, 13(27%) showed grade IV hematologic toxicity but treatment delay did not exceed 5 days. Two patients died of sepsis during chemoradiotherapy. Server weight(more than 10%) occurred in 9 patients(19%) during treatment. Nine patients(19%) developed radiation pneumonitis. Six of these patients had grad I(mild) pneumonitis with radiographic changes within the treatment fields. Three other patients had grade II pneumonitis, but none of theses patients had continuous symptoms after steroid treatment. Concurrent chemoradiotherapy for patients with advanced NSCLC was well tolerated with acceptable toxicity and achieved higher response rates than the first study, but rather low compliance rate(7%) in this study is worrisome. We need to improve nutritional support during treatment and to use G-CSF to improve leukopenia and if necessary, supportive care will given as in patients. Longer follow-up and larger sample size is needed to

  1. Neovascularity in patellar tendinopathy and the response to eccentric training: a case report using Power Doppler ultrasound.

    Science.gov (United States)

    McCreesh, Karen M; Riley, Sara J; Crotty, James M

    2013-12-01

    This report describes the case of an amateur soccer player with chronic patellar tendinopathy who underwent ultrasound imaging before and after engaging in an 8-week programme of eccentric exercise. On initial assessment, greyscale ultrasound imaging demonstrated tendon thickening and reduced echogenicity, while Power Doppler imaging demonstrated a large amount of neovascularity. After 8 weeks of an eccentric loading programme, the patient reported significantly improved symptoms and functional scores, while follow-up imaging demonstrated improvement in the echo appearance of the tendon and complete resolution of the neovascularity. The association between neovascularity and symptoms in tendinopathy research is conflicting, with a paucity of research in the area of patellar tendinopathy. While further research is needed to clarify the significance of greyscale and Power Doppler ultrasound changes in relation to symptoms in patellar tendinopathy, ultrasound imaging was shown to be a useful adjunct to diagnosis and outcome assessment in this case. Copyright © 2012 Elsevier Ltd. All rights reserved.

  2. A review of Alberta's environmental and emergency response capacity : learning the lessons and building change[Report of the Alberta Environmental Protection Commission

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-12-15

    Alberta's Environmental Commission was established in August 2005 following a train derailment and spill of Bunker C oil and pole treating oil into Lake Wabamun. Its role was to review and make recommendations on Alberta's ability to respond to environmental incidents. The Commission found that the problems and solutions to environmental protection go beyond the mandate of Alberta Environment. They lie within decisive and proactive emergency management and response systems. In light of growing industrial activity, as well as a growing population and economic base, the comprehensive response approach to an emergency must be world-class in order to minimize impacts on land, air, water, wildlife and people. The conclusions presented in this report refer to the overall system and the 5 frameworks that support it, including prevention and mitigation; preparedness; response; recovery; and research and knowledge. The Commission examined response systems in other provinces and jurisdiction and reviewed the current model in Alberta to assess its strength and weaknesses. Focus was on the following 6 objectives: recommend any changes needed to the Alberta government's capacity to respond to environmental incidents where industry cannot; review Alberta Environment's emergency response system in order to make recommendations to prevent, mitigate and respond to these incidents; review the provision of information needed in a report to Alberta Environment and the associated reporting process regarding the substances involved in spills; review potential high-risk situations affecting Alberta's lake and rivers as part of an overall risk management strategy; review best practices for preventing, mitigating and responding to incidents that can have a significant impact on the environment; and provide advice to the Ministries on safety and rail transportation issues to help them collaborate with the appropriate jurisdictions. It was concluded that action is

  3. DOD Major Automated Information Systems: Improvements Can Be Made in Reporting Critical Changes and Clarifying Leadership Responsibility

    Science.gov (United States)

    2016-03-01

    program has experienced, among other things, a schedule delay of 1 year or more, a full life-cycle cost increase of 25 percent or more over the original...on the quality of reporting of DOD MAIS programs. We conducted this performance audit from April 2015 to March 2016 in accordance with generally...accepted government auditing standards. Those standards require that we plan and perform the audit to obtain sufficient, appropriate evidence to provide

  4. Canada's Response to the Recommendations in the Tenth Biennial Report on Great Lakes Water Quality of the International Joint Commission

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The Government of Canada and Ontario are currently renegotiating the Canada-Ontario Agreement Respecting the Great Lakes Basin Ecosystem (COA). They are committed to restoring and maintaining the basin's chemical, physical and biological integrity and ensuring that it has a healthy, sustainable future. The COA has established a strategic framework for coordinated federal-provincial responsibilities regarding the Great Lakes basin ecosystem. This document presents responses to the recommendations of the International Joint Commission's (IJC) Tenth Biennial Report on how to improve the performance and effectiveness of government programs such as the Great Lakes Water Quality Agreement. According to the IJC, there are many challenges ahead, including: cleanup of Canadian Areas of Concern; controlling and preventing the further introduction of exotic species; mitigating the impact of rapid urban growth on environmental conditions throughout the basin; and reducing contaminants transported in the atmosphere over long distances to the Great Lakes. This document presented the government's responses to each of the following IJC recommendations regarding remedial action plans, threats to human health with respect to consumption of fish, contaminated sediment, airborne toxic substances, Great Lakes binational toxics strategy, land use, alien invasive species, and information and data management. IJC also recommended that indicators should be reported regarding whether the Great Lakes surface waters are suitable for drinking, swimming and whether fish are edible.

  5. Field studies of sweet potatoes and cowpeas in response to elevated carbon dioxide. Progress report. [Ipomoea batatas; Vigna unguiculata

    Energy Technology Data Exchange (ETDEWEB)

    Biswas, P.K.

    1985-01-01

    The physiological and biochemical effects of enriched CO/sub 2/ on sweet potatoes and cowpeas were studied in open top chambers. The main task was to assemble equipment to generate test atmospheres of CO/sub 2/ in the field, using open top chambers as the basic exposure unit for studying the response of sweet potatoes and cowpeas to enriched CO/sub 2/. Plant responses to CO/sub 2/ in open top chambers have been demonstrated by several investigators in a variety of crops. This study focused on growth and development of both sweet potatoes and cowpeas at levels of CO/sub 2/ ranging from the ambient level of 354 ppM to 659 ppM. The effects of CO/sub 2/ on leaf and stem weights, stem length, leaf area, and stomatal number and conductance were studied on both species. Additional studies on sweet potatoes included the effects of CO/sub 2/ on the weight, chemical content and quality of tubers. Additional studies on cowpeas included the effects of CO/sub 2/ on the weight of seeds and rate of nitrogen fixation. 27 figs., 35 tabs. (ACR)

  6. Aberrant endocrinology and ovarian response to clomiphene citrate during the course of an undiagnosed early intrauterine pregnancy: a case report.

    Science.gov (United States)

    Kallen, Amanda N; Luk, Janelle; Pal, Lubna

    2013-01-01

    This is an unusual case of embryonic exposure to clomiphene citrate (CC) in the setting of an undiagnosed early pregnancy with successful follicular response to CC and progression of pregnancy despite markedly attenuated serum progesterone and estradiol levels and a thin endometrium. A review of literature on the potential of CC for teratogenicity is presented. A 36-year-old woman underwent 2 ovulation inductions (OIs) with CC. Successful pregnancy followed the second OI cycle. Fetal measurements on transvaginal ultrasound identified the pregnancy to be chronologically advanced and consistent with the first OI treatment cycle. The follicular response to CC during the second OI cycle in the setting of ongoing early pregnancy, and pregnancy progression despite markedly attenuated endometrium, low serum levels of serum progesterone, and estradiol and embryonic exposure to CC, are notable. The possibility of inadvertent embryonic exposure to fertility drugs in the event of undiagnosed early pregnancy must be considered in infertile patients pursuing repeat treatment cycles. Serum beta-hCG testing should be considered before repeat treatments.

  7. Response to a selective serotonin reuptake inhibitor (citalopram) in major depressive disorder with melancholic features: a STAR*D report.

    Science.gov (United States)

    McGrath, Patrick J; Khan, Ahsan Y; Trivedi, Madhukar H; Stewart, Jonathan W; Morris, David W; Wisniewski, Stephen R; Miyahara, Sachiko; Nierenberg, Andrew A; Fava, Maurizio; Rush, A John

    2008-12-01

    This study examined demographic and clinical correlates of DSM-IV major depressive disorder with melancholic features and assessed whether melancholic features were predictive of response to a selective serotonin reuptake inhibitor antidepressant. Participants with major depressive disorder (N = 2875) at primary and specialty care sites who received the first step treatment with citalopram in the Sequenced Treatment Alternatives to Relieve Depression study were included. Patients were enrolled between July 2001 and April 2004. Melancholic features were ascribed by previously developed algorithms of telephone interview ratings prior to treatment. Demographics, clinical features, and treatment response were compared between those with and without melancholic features. The 23.5% of participants with melancholic features were characterized by higher severity scores, greater rates of previous suicide attempts and ratings of current suicidal risk, and more concurrent psychiatric comorbidity. Unadjusted remission rates for those with melancholic features were statistically significantly reduced in absolute terms by up to 8.4% compared to those without melancholic features, which is a 24.1% decrease in relative chance of remission (p rates were no longer different. Melancholic features are associated with a significantly reduced remission rate with an SSRI. This effect appears to be accounted for by demographic and clinical features associated with melancholic features. clinicaltrials.gov Identifier: NCT0021528. Copyright 2008 Physicians Postgraduate Press, Inc.

  8. The United Nations Global Compact Progress Reports as Management Control Instruments for Social Responsibility at Spanish Universities

    Directory of Open Access Journals (Sweden)

    Amber Wigmore-Álvarez

    2014-04-01

    Full Text Available Sustainability and social responsibility (SR have emerged as a new way of managing all types of organizations. It is necessary that the resulting policy be integrated transversely in the control processes. The environment is especially demanding of higher education institutions (HEIs and universities when it comes to behaving in a socially responsible manner due to their great influence in society. Many universities have adhered to the United Nations Global Compact (UNGC principles to prove their commitment and gain legitimacy. The Communication on Progress (COP is a management tool that helps to understand the level of implementation of the principles. Furthermore, COP analysis aids in establishing a process of continuous improvement in the management of the impacts that institutions have on their stakeholders. The aim of this study was to analyze the Spanish universities that have joined the Global Compact. Through a descriptive methodology, we identified the aspects that reflect this commitment and how this is integrated into their operational and educational processes. The results have shown that it is necessary to promote the integration of different international initiatives to guide the SR of universities. There are deficiencies in their SR management systems that prevent them from being more transparent, and it was found that in some cases, they are not aware of the implications the commitment can have in developed countries.

  9. A Longitudinal Study of the Effects of Child-Reported Maternal Warmth on Cortisol Stress Response 15 Years After Parental Divorce.

    Science.gov (United States)

    Luecken, Linda J; Hagan, Melissa J; Wolchik, Sharlene A; Sandler, Irwin N; Tein, Jenn-Yun

    2016-01-01

    The experience of parental divorce during childhood is associated with an increased risk of behavioral and physical health problems. Alterations in adrenocortical activity may be a mechanism in this relation. Parent-child relationships have been linked to cortisol regulation in children exposed to adversity, but prospective research is lacking. We examined maternal warmth in adolescence as a predictor of young adults' cortisol stress response 15 years after parental divorce. Participants included 240 youth from recently divorced families. Mother and child reports of maternal warmth were assessed at 6 time points across childhood, adolescence, and young adulthood. Offspring salivary cortisol was measured in young adulthood before and after a social stress task. Structural equation modeling was used to predict cortisol response from maternal warmth across early and late adolescence. Higher child-reported maternal warmth in early adolescence predicted higher child-reported maternal warmth in late adolescence (standardized regression = 0.45, standard error = 0.065, p child relationship after divorce and across development, as perceived by the child, may promote efficient biological regulation later in life. ClinicalTrials.gov Identifier: NCT01407120.

  10. Effects of Scale, Question Location, Order of Response Alternatives, and Season on Self-Reported Noise Annoyance Using ICBEN Scales: A Field Experiment.

    Science.gov (United States)

    Brink, Mark; Schreckenberg, Dirk; Vienneau, Danielle; Cajochen, Christian; Wunderli, Jean-Marc; Probst-Hensch, Nicole; Röösli, Martin

    2016-11-23

    The type of noise annoyance scale and aspects of its presentation such as response format or location within a questionnaire and other contextual factors may affect self-reported noise annoyance. By means of a balanced experimental design, the effect of type of annoyance question and corresponding scale (5-point verbal vs. 11-point numerical ICBEN (International Commission on Biological Effects of Noise) scale), presentation order of scale points (ascending vs. descending), question location (early vs. late within the questionnaire), and survey season (autumn vs. spring) on reported road traffic noise annoyance was investigated in a postal survey with a stratified random sample of 2386 Swiss residents. Our results showed that early appearance of annoyance questions was significantly associated with higher annoyance scores. Questionnaires filled out in autumn were associated with a significantly higher annoyance rating than in the springtime. No effect was found for the order of response alternatives. Standardized average annoyance scores were slightly higher using the 11-point numerical scale whereas the percentage of highly annoyed respondents was higher based on the 5-point scale, using common cutoff points. In conclusion, placement and presentation of annoyance questions within a questionnaire, as well as the time of the year a survey is carried out, have small but demonstrable effects on the degree of self-reported noise annoyance.

  11. Reliability, validity and responsiveness of the German self-reported foot and ankle score (SEFAS) in patients with foot or ankle surgery.

    Science.gov (United States)

    Arbab, Dariusch; Kuhlmann, Katharina; Schnurr, Christoph; Bouillon, Bertil; Lüring, Christian; König, Dietmar

    2017-10-10

    Patient-reported outcome measures are a critical tool in evaluating the efficacy of orthopedic procedures and are increasingly used in clinical trials to assess outcomes of health care. The intention of this study was to develop and culturally adapt a German version of the Self-reported Foot and Ankle Score (SEFAS) and to evaluate reliability, validity and responsiveness. According to Cross Cultural Adaptation of Self-Reported Measure guidelines forward and backward translation has been performed. The German SEFAS was investigated in 177 consecutive patients. 177 Patients completed the German SEFAS, Foot and Ankle Outcome Score (FAOS), Short-Form 36 and numeric scales for pain and disability (NRS) before and 118 patients 6 months after foot or ankle surgery. Test-Retest reliability, internal consistency, floor and ceiling effects, construct validity and minimal important change were analyzed. The German SEFAS demonstrated excellent test-retest reliability with ICC values of 0.97. Cronbach's alpha (α) value of 0.89 demonstrated strong internal consistency. No floor or ceiling effects were observed for the German version of the SEFAS. As hypothesized SEFAS correlated strongly with FAOS and SF-36 domains. It showed moderate (ES/SRM > 0.5) responsiveness between preoperative assessment and postoperative follow-up. The German version of the SEFAS demonstrated good psychometric properties. It proofed to be a valid and reliable instrument for use in foot and ankle patients. DRKS00007585.

  12. Confronting chemobrain: an in-depth look at survivors' reports of impact on work, social networks, and health care response.

    Science.gov (United States)

    Boykoff, Nelli; Moieni, Mona; Subramanian, Saskia Karen

    2009-12-01

    Mild cognitive impairment following chemotherapy is one of the most commonly reported post treatment symptoms by breast cancer survivors. This deterioration in cognitive function, commonly referred to as "chemobrain" or "chemofog," was largely unacknowledged by the medical community until recent years. Although chemobrain has now become the subject of more vigorous exploration, little is known about this specific phenomenon's psychosocial impact on breast cancer survivors. This research documents in-depth the effects that cognitive impairment has on women's personal and professional lives, and our data suggest that greater attention needs to be focused on this arena of survivorship. The results are based on an in-depth qualitative study of 74 white and African American breast cancer survivors in California who experience post-treatment side effects. The data reported herein were obtained through the use of focus groups and in-depth interviews. Our data indicate that cognitive impairment can be problematic for survivors, with many asserting that it is their most troublesome post treatment symptom. Survivors report diminished quality of life and daily functioning as a result of chemobrain. Respondents detail a range of coping strategies that they are forced to employ in order to manage their social and professional lives. Chemobrain significantly impairs a proportion of cancer survivors, at great cost to them economically, emotionally, and interpersonally. This suggests that more research needs to be conducted on the psychosocial ramifications of post treatment symptoms in order to inform the efforts of the medical and mental health communities as well as the support networks of survivors. A better and broader understanding of the effects of cognitive impairment both in the medical community and among lay people could pave the way for improved social and psychological services for this population.

  13. Fundamental Principles of Raising an Antitumour Immune Response in Vivo: A Complex Model, a Case Report, and a Perspective

    Directory of Open Access Journals (Sweden)

    Suzy M. Scholl

    2014-11-01

    Full Text Available In preclinical model systems, the fundamental principles underlying a successful and durable anti-tumour immune response are well demonstrated. In clinical practice, significant successes in Phase III trials have been few over the last decades, but the field has gained tremendous interest following recent advances showing the activity of checkpoint blockade inhibitors. Still, at this time we do not fully understand why some people respond while others do not; nor do we completely understand which clinical and immunological monitoring tools we need to put in place to make immunotherapy a more controlled medical science. Reviewing recent evidence suggests that for a successful and controlled immunotherapy, we may need to juggle with several conditions at the same time; there is a need for the endogenous or exogenous addition of tumour antigens for a favourable tumour microenvironment, and for an immune system which remains actionable towards T cell (effector activity by checkpoint blockade inhibitors.

  14. Response of a forest ecotone to ionizing radiation. Summary report, 15 October 1972--14 July 1975

    International Nuclear Information System (INIS)

    Murphy, P.G.

    1975-01-01

    Compositional and structural characteristics of three forest types, including aspen dominated, maple-birch dominated, and an intervening ecotone, were studied before and after chronic γ irradiation in northern Wisconsin. Irradiation occurred during the summer of 1972. By the summer of 1973, the density of viable tree seedlings at 10 m from the radiation source was substantially reduced in all three areas relative to the preirradiation densities of 1971. Re-establishment of tree seedlings has thus far been prevented by the vigorous development of ground vegetation at 10 m. At 20 m, the density of seedlings in the three areas increased during the period between 1971 and 1973 in response to the partially opened canopy. Leaf litter production was reduced by up to 94 percent at 10 m and 64 percent at 20 m during the period between 1971 and 1973 in the irradiated areas. (U.S.)

  15. Nuclear Safety: Our Overriding Priority. EDF Group Report 2015 in response to FTSE4Good Nuclear Criteria

    International Nuclear Information System (INIS)

    Maillart, H.

    2015-01-01

    EDF is the world's leading nuclear operator with 74.8 GW of installed capacity in France, the United Kingdom and the United States, an EPR under construction in France, and 2 EPRs under construction in China through TNPJVC (EDF 30%), a joint venture with CGNPC. As such, EDF acts at all stages in the life of its power plants (design, construction, operation, decommissioning) to: - ensure rigorous operation of facilities; - prevent all incidents and accidents; - reduce the impact of any incidents or accidents that might nevertheless occur. The main safety measures were published in a single document in 2015 setting out the Group's nuclear safety policy. Each nuclear operating company inside the Group acts in compliance with the legal obligations and regulations specific to its host country. Each company works to ensure and continuously improve its safety performance with its own methods, skills and values. The EDF Group respects national differences. At the same time it frames common principles to deliver the highest level of incident prevention and protection of the public, workers and the environment. This policy applies to new projects (overall architecture, design and construction) and all existing plants (operation, maintenance, waste management, decommissioning and engineering). The Group works closely with its industrial partners to deliver these objectives. Each company is responsible for the proper operation of its nuclear activities, and delegates responsibilities appropriately to each level of management or operation. The Group guarantees the allocation of resources needed to ensure nuclear safety. An in-house independent nuclear safety function is in place at power plant level, company level and Group level. Each has a duty to alert senior management of inappropriate or inadequate line management response. Nuclear safety is the absolute priority for the EDF Group at every stage of the plant life-cycle. Each company is responsible for ensuring

  16. Final Technical Report: Response of Mediterranean-Type Ecosystems to Elevated Atmospheric CO2 and Associated Climate Change

    Energy Technology Data Exchange (ETDEWEB)

    Oechel, Walter C

    2002-08-15

    This research incorporated an integrated hierarchical approach in space, time, and levels of biological/ecological organization to help understand and predict ecosystem response to elevated CO{sub 2} and concomitant environmental change. The research utilized a number of different approaches, and collaboration of both PER and non-PER investigators to arrive at a comprehensive, integrative understanding. Central to the work were the CO{sub 2}-controlled, ambient Lit, Temperature controlled (CO{sub 2}LT) null-balance chambers originally developed in the arctic tundra, which were re-engineered for the chaparral with treatment CO{sub 2} concentrations of from 250 to 750 ppm CO{sub 2} in 100 ppm increments, replicated twice to allow for a regression analysis. Each chamber was 2 meters on a side and 2 meters tall, which were installed over an individual shrub reprouting after a fire. This manipulation allowed study of the response of native chaparral to varying levels of CO{sub 2}, while regenerating from an experimental burn. Results from these highly-controlled manipulations were compared against Free Air CO{sub 2} Enrichment (FACE) manipulations, in an area adjacent to the CO{sub 2}LT null balance greenhouses. These relatively short-term results (5-7 years) were compared to long-term results from Mediterranean-type ecosystems (MTEs) surrounding natural CO{sub 2} springs in northern Italy, near Laiatico, Italy. The springs lack the controlled experimental rigor of our CO{sub 2}LT and FACE manipulation, but provide invaluable validation of our long-term predictions.

  17. A case report of a patient with metastatic ocular melanoma who experienced a response to treatment with the BRAF inhibitor vemurafenib.

    Science.gov (United States)

    Maleka, A; Åström, G; Byström, P; Ullenhag, G J

    2016-08-12

    Conjunctival malignant melanoma (CMM) is a rare malignancy and in the advanced setting there is no effective treatment. In contrast, half of cutaneous melanomas have BRAF mutations and treatment with BRAF inhibitors is established for patients with disseminated disease. The most common form of ocular melanoma, uveal melanoma, lacks these mutations, however, their presence has been reported for CMM. We used the BRAF inhibitor vemurafenib to treat a 53 year-old female suffering from a BRAF(V600E) mutated metastatic CMM. The patient benefited from the treatment, a response was evident within a week and she experienced a progression free survival of four months. To our knowledge, this is the first described case of response to vemurafenib treatment in a patient with ocular melanoma.

  18. The six year report: Acidification of surface water in Europe and North America. Dose/response relationships and long-term trends

    Energy Technology Data Exchange (ETDEWEB)

    Skjelkvaale, B.L.; Newell, A.D.; Raddum, G.; Johannessen, M.; Hovind, H.; Tjomsland, T.; Wathne, B.M.

    1994-12-31

    This report discusses The International Cooperative Programme on Assessment and Monitoring of Acidification of Rivers and Lakes, which is designed to (1) establish degree and extent of acidification of surface waters, (2) evaluate dose/response relationships and (3) define long-term trends and variations in aquatic chemistry and biota attributable to atmospheric pollution. Data from 200 sites in 14 countries of Europe and North America are available. Dose/response relationships show that the fauna is adapted to different water qualities in different regions, and that critical limits for the fauna must be calculated according to data for the specific region. Long-term trends of water chemistry show decreases in SO{sub 4}{sup 2-} and Ca{sup 2+} at many sites. Nitrate shows no consistent trends. 66 refs., 26 figs., 16 tabs.

  19. The Spanish version of the Self-Determination Inventory Student Report: application of item response theory to self-determination measurement.

    Science.gov (United States)

    Mumbardó-Adam, C; Guàrdia-Olmos, J; Giné, C; Raley, S K; Shogren, K A

    2018-04-01

    A new measure of self-determination, the Self-Determination Inventory: Student Report (Spanish version), has recently been adapted and empirically validated in Spanish language. As it is the first instrument intended to measure self-determination in youth with and without disabilities, there is a need to further explore and strengthen its psychometric analysis based on item response patterns. Through item response theory approach, this study examined item observed distributions across the essential characteristics of self-determination. The results demonstrated satisfactory to excellent item functioning patterns across characteristics, particularly within agentic action domains. Increased variability across items was also found within action-control beliefs dimensions, specifically within the self-realisation subdomain. These findings further support the instrument's psychometric properties and outline future research directions. © 2017 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.

  20. Four weeks of paritaprevir/ritonavir/ombitasvir plus dasabuvir encountering dengue fever resulted in sustained virological response in an HCV patient: A case report.

    Science.gov (United States)

    Huang, Chung-Feng; Jang, Tyng-Yuan; Lu, Po-Liang; Yu, Ming-Lung

    2016-11-01

    Direct antiviral agent (DAA) has been the standard of care for patients with hepatitis C virus (HCV) infection. Twelve weeks of paritaprevir/ritonavir/ombitasvir plus dasabuvir (PROD) with or without ribavirin has shown to have a sustained virological response at post-treatment 12 weeks (SVR12) rate of >90% in HCV genotype 1 (HCV-1) patients. We report a HCV-1b patient who received only 25 days of PROD treatment. The patient early terminated treatment due to dengue fever but eventually achieved SVR12. It may attribute to low baseline viral loads and extraordinarily rapid suppression of HCV after treatment day1. The finding may shed light for possible response-guided-therapy for so-called ultra-super-responders in the DAA era. Whether the dengue virus, the Flaviviridae family as with HCV, enhanced the HCV clearance remains unclear and needs further exploration.

  1. American cutaneous leishmaniasis caused by Leishmania (Viannia braziliensis resistant to meglumine antimoniate, but with good response to pentamidine: a case report

    Directory of Open Access Journals (Sweden)

    Maria Inês Fernandes Pimentel

    2011-04-01

    Full Text Available This is a case report of a Brazilian soldier with cutaneous leishmaniasis. The lesion relapsed following two systemic treatments with meglumine antimoniate. The patient was treated with amphotericin B, which was interrupted due to poor tolerance. Following isolation of Leishmania sp., six intralesional infiltrations of meglumine antimoniate resulted in no response. Leishmania sp promastigotes were again isolated. The patient was submitted to intramuscular 4mg/kg pentamidine. Parasites from the first and second biopsies were identified as Leishmania (Viannia braziliensis; those isolated from the first biopsy were more sensitive to meglumine antimoniate in vitro than those isolated from the second biopsy. No relapse was observed.

  2. PSA Response to Lenalidomide Therapy in a Pre-Treated Patient with Metastatic Prostate Cancer Refractory to Hormones and Chemotherapy: A Case Report

    Directory of Open Access Journals (Sweden)

    Joan Manel Gasent Blesa

    2012-04-01

    Full Text Available Hormone-resistant prostate cancer (HRPC occurs when prostate cancer is no longer responsive to hormone therapy. Treatment options are limited, and there is a clear necessity for therapies that improve outcome. Preclinical and clinical evidence supports the role of the immunomodulatory agent lenalidomide in HRPC. In this paper, we report that lenalidomide showed antitumoral activity in a patient with HRPC and bone metastases pre-treated with chemotherapy, decreased the PSA level and improved the patient’s health status for the first 5 months. It is important to emphasize that it was not associated with hematologic toxicity.

  3. Sustainability reporting

    NARCIS (Netherlands)

    Kolk, A.

    2005-01-01

    This article gives an overview of developments in sustainability (also sometimes labelled corporate social responsibility) reporting. The article will first briefly indicate how accountability on social and environmental issues started, already in the 1970s when social reports were published.

  4. Improved National Response to Climate Change: Aligning USGCRP reports and the U.S. Climate Resilience Toolkit

    Science.gov (United States)

    Lipschultz, F.; Dahlman, L. E.; Herring, D.; Fox, J. F.

    2017-12-01

    As part of an effort to coordinate production and distribution of scientific climate information across the U.S. Government, and to spur adaptation actions across the nation, the U.S. Global Change Research Program (USGCRP) has worked to better integrate the U.S. Climate Resilience Toolkit (CRT) and its Climate Explorer (CE) tool into USGCRP activities and products. Much of the initial CRT content was based on the Third National Climate Assessment (NCA3). The opportunity to integrate current development of NCA4—scheduled for release in late 2018—with CRT and CE can enhance all three projects and result in a useable and "living" NCA that is part of USGCRP's approach to sustained climate assessment. To coordinate this work, a USGCRP-led science team worked with CRT staff and CE developers to update the set of climate projections displayed in the CE tool. In concert with the USGCRP scenarios effort, the combined team selected the Localized Constructed Analogs (LOCA) dataset for the updated version of CE, based on its capabilities for capturing climate extremes and local climate variations. The team identified 28 variables from the LOCA dataset for display in the CE; many of these variables will also be used in USGCRP reports. In CRT engagements, communities with vulnerable assets have expressed a high value for the ability to integrate climate data available through the CE with data related to non-climate stressors in their locations. Moving forward, the teams intend to serve climate information needs at additional spatial scales by making NCA4 content available via CE's capability for dynamic interaction with climate-relevant datasets. This will permit users to customize the extent of data they access for decision-making, starting with the static NCA4 report. Additionally, NCA4 case studies and other content can be linked to more in-depth content within the CRT site. This capability will enable more frequent content updates than can be managed with quadrennial

  5. Special Issue on "Social Responsibility Accounting and Reporting in Times of ‘Sustainability Downturn/Crisis’

    Directory of Open Access Journals (Sweden)

    Carmen Correa-Ruiz

    2011-12-01

    Full Text Available At a time when sustainability performance does not seem to match the expectations raised by the sustainable development concept and, moreover, when the economic downturn and crisis could be further eroding social and environmental concerns and values, the notion of sustainability crisis provides an interesting starting point to reflect on the role of Social and Environmental Accounting Research. Lack of humanity and values, short term economic approach, institutional capture and misunderstanding and misuse of democracy, have all served as catalysts of sustainability downturn and crisis. Thus, this editorial attempts to advance public interest accounting by discussing the controversy around Sustainability and Corporate Social Responsibility, expecting that the constitutive effects of researchers’ words in this special issue and in future research agendas, will result in more transformative power relations able to enhance a healthy democracy inspired by the capacity to do things and to transform individuals’ attitudes and behaviours, as well as the institutional response to the sustainability crisis.En una época en la que el desempeño en materia de sostenibilidad parece no cumplir las expectativas creadas por el concepto de desarrollo sostenible y, en la que además, la recesión y la crisis económica podría estar erosionando aún más los valores y preocupaciones sociales y medioambientales, la noción de crisis de sostenibilidad proporciona un interesante punto de partida para reflexionar sobre el papel de la investigación en Contabilidad Social y Medioambiental. La falta de humanidad y la ausencia de valores, el enfoque económico cortoplacista, la captura institucional y la democracia mal entendida y su uso incorrecto, han servido como catalizadores de la crisis y la recesión de la sostenibilidad. Así, el presente editorial pretende avanzar en la contabilidad como interés general, debatiendo sobre la controversia existente

  6. Sustained Complete Response to Metronomic Chemotherapy in a Child with Refractory Atypical Teratoid Rhabdoid Tumor: A Case Report

    Directory of Open Access Journals (Sweden)

    Mahe Berland

    2017-11-01

    Full Text Available Atypical teratoid rhabdoid tumor (ATRT is a rare and highly aggressive embryonal tumor of the central nervous system with a dismal prognosis and no definitive guidelines for treatment, especially at relapse or in case of refractory disease. Metronomic chemotherapy (MC has emerged as a new treatment option in solid malignancies, with lower toxicity and is frequently combined with drug repositioning. We report a case of ATRT in an 8-year-old boy who progressed during multimodal therapy including surgical resection, chemotherapy and radiotherapy. He was treated with MC involving continuous oral celecoxib with alternating metronomic etoposide and cyclophosphamide, in combination with biweekly bevacizumab and monthly intrathecal liposomal cytarabine. To date, he remains clinically and symptomatically disease-free with a follow-up of 10 months. The treatment was well-tolerated. Metronomics represent a possible alternative regimen for children with recurrent or progressive ATRT.

  7. Modeling the response of plants and ecosystems to global change. Progress report, September 1, 1989--August 31, 1990

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, J.F.; Harley, P.; Hilbert, D.W.; Kemp, P.R.; Cornelius, J.M.; Tenhunen, J.D.

    1990-05-03

    An initiated close collaboration with experimentalists at Kansas State University that will provide data necessary to models of response to global change. This collaboration also includes co-operative experimental work carried out by staff at SERG that expands the range of ecosystem level processes measured in the open top chambers at Manhatan, Kansas. Several factors suggest that close co-operation between our two groups will be especially advantageous for the realization of the broad goals of the DOE CO{sub 2} consortium: (1) The experimental effort is very extensive, chambers and smaller closed chambers are experiments will provide information at levels. (2) We have been in close contact with the Kansas State group for some time and are beginning a major addition to the open chamber studies this summer. Consequently, we will be present at the field site for much of the summer, working directly with the group. (3) Several members of our group have extensive experience working in grasslands and our ecosystem model is currently well structured to handle grassland simulations.

  8. Transgenic mouse model harboring the transcriptional fusion ccl20-luciferase as a novel reporter of pro-inflammatory response.

    Directory of Open Access Journals (Sweden)

    Martina Crispo

    Full Text Available The chemokine CCL20, the unique ligand of CCR6 functions as an attractant of immune cells. Expression of CCL20 is induced by Toll-like Receptor (TLR signaling or proinflammatory cytokine stimulation. However CCL20 is also constitutively produced at specific epithelial sites of mucosa. This expression profile is achieved by transcriptional regulation. In the present work we characterized regulatory features of mouse Ccl20 gene. Transcriptional fusions between the mouse Ccl20 promoter and the firefly luciferase (luc encoding gene were constructed and assessed in in vitro and in vivo assays. We found that liver CCL20 expression and luciferase activity were upregulated by systemic administration of the TLR5 agonist flagellin. Using shRNA and dominant negative form specific for mouse TLR5, we showed that this expression was controlled by TLR5. To address in situ the regulation of gene activity, a transgenic mouse line harboring a functional Ccl20-luc fusion was generated. The luciferase expression was highly concordant with Ccl20 expression in different tissues. Our data indicate that the transgenic mouse model can be used to monitor activation of innate response in vivo.

  9. Response of a forest ecotone to ionizing radiation. Progress report, 15 October 1974--14 October 1975

    International Nuclear Information System (INIS)

    Murphy, P.G.

    1975-01-01

    Compositional and structural characteristics of three forest types, including aspen dominated, maple-birch dominated and an intervening ecotone, were studied before and after chronic γ irradiation in northern Wisconsin. Irradiation occurred during the summer of 1972. By the summer of 1973 the density of viable tree seedlings at 10 m from the radiation source was substantially reduced in all three areas relative to the preirradiation densities of 1971. Re-establishment of tree seedlings has, as of June 1975, been prevented by the vigorous development of ground vegetation. At 20 m, the density of seedlings in the three areas increased during the period between 1971 and 1973 in response to the partially opened canopy. The overall density of seedlings of Populus tremuloides and Acer rubrum increased markedly in the three areas and P. tremuloides invaded some areas in which it had not been found prior to irradiation. By 1974 many of the seedlings at 20 m had reached the sapling size-class. Viable trees greater than 2.5 cm, dbh were eliminated at 10 m in all three areas by June 1974 and were reduced in density of 20 m. Leaf litter production was reduced by up to 94 percent at 10 m and 64 percent at 20 m during the period between 1971 and 1973 in the irradiated areas. (U.S.)

  10. Differential response to hypomethylating agents based on sex: a report on behalf of the MDS Clinical Research Consortium (MDS CRC).

    Science.gov (United States)

    DeZern, Amy E; Zeidan, Amer M; Barnard, John; Hand, Wesley; Al Ali, Najla; Brown, Francis; Zimmerman, Cassie; Roboz, Gail J; Garcia-Manero, Guillermo; Steensma, David P; Komrokji, Rami S; Sekeres, Mikkael A

    2017-06-01

    First-line therapy for higher-risk myelodysplastic syndromes (MDS) includes decitabine (DAC) or azacitidine (AZA). Variables have not identified differential response rates between these. We assessed the influence of patient sex on outcomes including overall survival (OS) in 642 patients with higher-risk MDS treated with AZA or DAC. DAC-treated patients (35% of females, 31% of males) had marginally better OS than AZA-treated patients (p = .043), (median OS of 18.7 months versus 16.4 months), but the difference varied strongly by sex. Female patients treated with DAC had a longer median OS (21.1 months, 95% CI: 16.0-28.0) than female patients treated with AZA (13.2 months, 95% CI: 11.0-15.9; p = .0014), while for males there was no significant difference between HMAs (median OS 18.3 months with DAC versus 17.9 months for AZA, p = .59). The biological reason for this variability is unclear, but may be a consequence of differences in cytidine deaminase activity between men and women.

  11. Report on the observed response of Javan lutungs (Trachypithecus auratus mauritius) upon encountering a reticulated python (Python reticulatus).

    Science.gov (United States)

    Tsuji, Yamato; Prayitno, Bambang; Suryobroto, Bambang

    2016-04-01

    We observed an encounter between a reticulated python (Python reticulatus) and a group of wild Javan lutungs (Trachypithecus auratus mauritius) at the Pangandaran Nature Reserve, West Java, Indonesia. A python (about 2 m in length) moved toward a group of lutungs in the trees. Upon seeing the python, an adult male and several adult female lutungs began to emit alarm calls. As the python approached, two adult and one sub-adult female jumped onto a branch near the python and began mobbing the python by shaking the branch. During the mobbing, other individuals in the group (including an adult lutung male) remained nearby but did not participate. The python then rolled into a ball-like shape and stopped moving, at which point the lutungs moved away. The total duration of the encounter was about 40 min, during which time the lutungs stopped feeding and grooming. Group cohesiveness during and after the encounter was greater than that before the encounter, indicating that lutungs adjust their daily activity in response to potential predation risk.

  12. Parent and Child Independent Report of Emotional Responses to Asthma-Specific Vignettes: The Relationship Between Emotional States, Self-Management Behaviors, and Symptoms.

    Science.gov (United States)

    Conn, Kelly M; Fisher, Susan G; Rhee, Hyekyun

    2016-01-01

    Little is known about the emotional intelligence (EI) of parents and their children with asthma. Objectives of this study were to assess: 1) parent's and children's report of emotions in response to an asthma vignette (proxy for EI) and 2) the relationship between emotions, self-management behaviors, and symptoms. We conducted a descriptive, mixed methods study of children 7-12 years old with asthma. Parent-Child dyads (n=104) responded to an asthma vignette to gain insight into emotions, symptoms, and self-management behaviors. Additional questions assessed confidence and worry using a 5-point Likert scale. Thematic analyses and descriptive statistics were used to assess qualitative and quantitative outcomes. Children were predominantly male (58%), 7-9 (58%), and White (46%). The most common negative emotions reported by children were scared and sad. Children who sought help from an adult were less likely to report using medications compared to children who did not seek help (39.5% vs. 62.3%, p=.029). Children with low worry and high confidence had fewer symptoms compared to children reporting high worry and low confidence (symptoms: days 3.24 vs. 6.77, p=.012, nights 2.71 vs. 5.36, p=.004). Children provided appropriate emotional responses to the asthma vignette; emotions were related to self-management behaviors and symptoms. More studies are needed to specifically assess EI in this population. Parents and children with greater EI may be better able to understand their needs, engage in self-management behaviors, and communicate with their nurses, to improve their support network and ability to access services. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. An investigation of outcome expectancies as a predictor of treatment response for combat veterans with PTSD: comparison of clinician, self-report, and biological measures.

    Science.gov (United States)

    Price, Matthew; Maples, Jessica L; Jovanovic, Tanja; Norrholm, Seth D; Heekin, Mary; Rothbaum, Barbara O

    2015-06-01

    Outcome expectancy, or the degree to which a client believes that therapy will result in improvement, is related to improved treatment outcomes for multiple disorders. There is a paucity of research investigating this relation in regards to posttraumatic stress disorder (PTSD). Additionally, the bulk of the research on outcome expectancy and treatment outcomes has relied mostly on self-report outcome measures. The relation between outcome expectancy on self-report measures, clinician-rated measures, and two biological indices (fear-potentiated startle and cortisol reactivity) of PTSD symptoms was explored. The sample included combat veterans (N = 116) treated with virtual reality exposure therapy for PTSD. Results supported a negative association between outcome expectancy and both self-report and clinician-rated symptoms at the conclusion of treatment, but outcome expectancy was related to the magnitude of change during treatment for self-report measures only. Outcome expectancy was unrelated to biological measures of treatment response. These findings suggest that outcome expectancy may be related to patient and clinician perceptions of outcomes, but not biological indices of outcome for PTSD. © 2015 Wiley Periodicals, Inc.

  14. Changes in water content in response to an acute bout of eccentric loading in a patellar tendon with a history of tendinopathy: A case report.

    Science.gov (United States)

    Ho, Kai-Yu; Kulig, Kornelia

    2016-10-01

    This case-based report assessed resting water content and exercise-driven water exchange within a tendon with a history of tendinopathy and compared the response to that of a healthy uninvolved tendon. Case Report. University imaging center. The participant was a 27-year-old female basketball player 39 months following knee trauma. Patellar tendinopathy developed 12 months after the injury episode and was treated with eccentric exercises. Eighteen months from the beginning of the first eccentric training bout, the participant reported full resolution of symptoms and returned to her pre-injury sport participation without symptoms. Eccentric decline squat exercise. Tendon water content obtained from magnetic resonance imaging (MRI). MRI acquired 39 months post-injury demonstrated increased resting water content of the involved tendon (involved: 91.1% vs. uninvolved: 84.6%). Immediately after the eccentric squat maneuver, water content decreased on both involved and uninvolved tendons (involved: 89.5% vs. uninvolved: 83.3%). Elevated resting water content of the involved tendon found in this report may be indicative of reduced tendon stiffness. A similar amount of water content reduction was observed on both sides following mechanical loading, suggesting that the involved tendon may respond to the eccentric exercise similarly to the uninvolved tendon. Future investigations are needed to study the relationships among tendon water exchanges, mechanical properties, patient symptoms, and tissue injuries.

  15. Report on the emergency response training and equipment activities through fiscal year 1992 for the transportation of transuranic waste to the Waste Isolation Pilot Plant

    International Nuclear Information System (INIS)

    1992-11-01

    The Waste Isolation Pilot Plant (WIPP) is a research and development facility with the mission of demonstrating the safe shipment, emplacement, and retrieval of radioactive transuranic (TRU) wastes resulting from the defense activities and programs of the United States. It is the only long-term storage facility constructed for TRU waste. This report provides the status on the Department of Energy (DOE) efforts as of September 30, 1992, regarding emergency response training provided to local, state, and tribal governments for waste shipments to the WIPP, as required by section 16(c)(1)(A) of the Waste Isolation Pilot Plant Land Withdrawal Act (Public Law 102-579). This is an update to the April 1992 report (DOE/WIPP 92003) which provided status through 1991. This report will be updated and issued annually. Because of a growing public awareness of transportation-activities involving nuclear materials, this report was prepared to provide a status of the DOE's activities in this regard, as well as the cooperative efforts between the DOE and state and tribal governments

  16. The Impact of Two Different Transfusion Strategies on Patient Immune Response during Major Abdominal Surgery: A Preliminary Report

    Directory of Open Access Journals (Sweden)

    Kassiani Theodoraki

    2014-01-01

    Full Text Available Blood transfusion is associated with well-known risks. We investigated the difference between a restrictive versus a liberal transfusion strategy on the immune response, as expressed by the production of inflammatory mediators, in patients subjected to major abdominal surgery procedures. Fifty-eight patients undergoing major abdominal surgery were randomized preoperatively to either a restrictive transfusion protocol or a liberal transfusion protocol (with transfusion if hemoglobin dropped below 7.7 g dL−1 or 9.9 g dL−1, respectively. In a subgroup of 20 patients randomly selected from the original allocation groups, blood was sampled for measurement of IL-6, IL-10, and TNFα. Postoperative levels of IL-10 were higher in the liberal transfusion group on the first postoperative day (49.82±29.07 vs. 15.83±13.22 pg mL−1, P<0.05. Peak postoperative IL-10 levels correlated with the units of blood transfused as well as the mean duration of storage and the storage time of the oldest unit transfused (r2=0.38, P=0.032, r2=0.52, P=0.007, and r2=0.68, P<0.001, respectively. IL-10 levels were elevated in patients with a more liberal red blood cell transfusion strategy. The strength of the association between anti-inflammatory IL-10 and transfusion variables indicates that IL-10 may be an important factor in transfusion-associated immunomodulation. This trial is registered under ClinicalTrials.gov Identifier: NCT02020525.

  17. Interactions of CO{sub 2} with temperature and other climate variables: response of vegetation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Knipling, E.B.

    1995-02-28

    The overall objectives of this project were: (1) to examine experimentally, for major crop species, the interacting effects of CO{sub 2} concentration, temperature, and water availability on plant growth and development, (2) to model these interactions, and (3) to continue developing physiologically-based mechanistic models for predicting crop response to increased CO{sub 2} concentration and future global climate change. To meet these objectives, controlled-environment studies were conducted on cotton, lemon, rice, and soybean and a long-term open-top chamber study was continued on orange. Much progress was made on development of plant growth models for cotton, wheat, rice, and soybean. In addition, there were two special modeling efforts which have the potential for contributing to all of the crop models. These efforts are concerned with modeling root growth and physical and chemical processes in soil and with modeling the effect of stomatal aperture on photosynthesis and transpiration rates as a function of CO{sub 2} concentration, temperature, and vapor pressure deficit. The root growth and soil process modeling is important because it enables us to estimate the water available to the plant. The modeling of effects of stomatal aperture on photosynthesis and transpiration rates enables them to estimate dry weight gain and water use by the plant. These are both important components of the interaction of CO{sub 2} concentration with temperature and water availability. The work on stomatal aperture, photosynthesis, and transpiration has the added benefit of allowing us to improve predictions of energy partitioning by the terrestrial biosphere. The lack of realistic energy partitioning is a serious deficiency of the present general circulation models which are used to predict how climate will change. An additional important aspect of the rice experiments is a study of methane emissions of paddy-grown (i.e., flooded) rice grown under two levels of CO{sub 2} and three

  18. A whole blood monokine-based reporter assay provides a sensitive and robust measurement of the antigen-specific T cell response

    Directory of Open Access Journals (Sweden)

    Bennett Sophia C

    2011-08-01

    Full Text Available Abstract Background The ability to measure T-cell responses to antigens is proving critical in the field of vaccine development and for understanding immunity to pathogens, allergens and self-antigens. Although a variety of technologies exist for this purpose IFNγ-ELISpot assays are widely used because of their sensitivity and simplicity. However, ELISpot assays cannot be performed on whole blood, and require relatively large volumes of blood to yield sufficient numbers of peripheral blood mononuclear cells. To address these deficiencies, we describe an assay that measures antigen-specific T cell responses through changes in monokine gene transcription. The biological amplification of the IFNγ signal generated by this assay provides sensitivity comparable to ELISpot, but with the advantage that responses can be quantified using small volumes of whole blood. Methods Whole blood or peripheral blood mononuclear cells (PBMCs from healthy controls and immunosuppressed recipients of solid organ transplants were incubated with peptide pools covering viral and control antigens or mitogen for 20 hours. Total RNA was extracted and reverse transcribed before amplification in a TaqMan qPCR reaction using primers and probes specific for MIG (CXCL9, IP-10 (CXCL10 and HPRT. The induction of MIG and IP-10 in response to stimuli was analysed and the results were compared with those obtained by ELISpot. Results Antigen-specific T cell responses can be measured through the induction of MIG or IP-10 gene expression in PBMCs or whole blood with results comparable to those achieved in ELISpot assays. The biological amplification generated by IFNγ-R signaling allows responses to be detected in as little as 25 μL of whole blood and enables the assay to retain sensitivity despite storage of samples for up to 48 hours prior to processing. Conclusions A monokine-based reporter assay provides a sensitive measure of antigen-specific T cell activation. Assays can be

  19. Double-standards in reporting of risk and responsibility for sexual health: a qualitative content analysis of negatively toned UK newsprint articles.

    Science.gov (United States)

    Martin, Susan P; McDaid, Lisa M; Hilton, Shona

    2014-08-04

    The need to challenge messages that reinforce harmful negative discourses around sexual risk and responsibility is a priority in improving sexual health. The mass media are an important source of information regularly alerting, updating and influencing public opinions and the way in which sexual health issues are framed may play a crucial role in shaping expectations of who is responsible for sexual health risks and healthy sexual practices. We conducted an in-depth, qualitative analysis of 85 negatively toned newspaper articles reporting on sexual health topics to examine how risk and responsibility have been framed within these in relation to gender. Articles published in 2010 in seven UK and three Scottish national newspapers were included. A latent content analysis approach was taken, focusing on interpreting the underlying meaning of text. A key theme in the articles was men being framed as a risk to women's sexual health, whilst it was part of a women's role to "resist" men's advances. Such discourses tended to portray a power imbalance in sexual relationships between women and men. A number of articles argued that it was women who needed to take more responsibility for sexual health. Articles repeatedly suggested that women and teenage girls in particular, lacked the skills and confidence to negotiate safer sex and sex education programmes were often presented as having failed. Men were frequently portrayed as being more promiscuous and engaging in more risky sexual health behaviours than women, yet just one article drew attention to the lack of focus on male responsibility for sexual health. Gay men were used as a bench mark against which rates were measured and framed as being a risk and at risk. The framing of men as a risk to women, whilst women are presented at the same time as responsible for patrolling sexual encounters, organising contraception and preventing sexual ill health reinforces gender stereotypes and undermines efforts to promote a

  20. Pembrolizumab for metastatic melanoma in a renal allograft recipient with subsequent graft rejection and treatment response failure: a case report.

    Science.gov (United States)

    Kwatra, Vineet; Karanth, Narayan V; Priyadarshana, Kelum; Charakidis, Michail

    2017-03-19

    Transplant patients were excluded from the pivotal phase III trials of checkpoint inhibitors in metastatic melanoma. The efficacy and toxicity profiles of checkpoint inhibitors in this cohort of patients are not well described. To the best of our knowledge, this is the first case report of a renal transplant patient with stage IV melanoma treated with a programmed cell death protein 1 checkpoint inhibitor that led to both treatment failure and renal graft rejection. We present a case of a 58-year-old white man with a long-standing cadaveric renal transplant who was diagnosed with a B-Raf Proto-Oncogene, Serine/Threonine Kinase wild-type metastatic melanoma. He was treated with first-line pembrolizumab but experienced subsequent graft failure and rapid disease progression. This case highlights the risks associated with the administration of checkpoint inhibitors in patients with a renal transplant and on immunosuppressive therapy. More specifically, it adds to the literature indicating that, compared with the cytotoxic T-lymphocyte-associated protein 4 inhibitor ipilimumab, anti-programmed cell death protein 1 agents are more likely to lead to renal graft failure. Additionally, these novel immunotherapeutics may be ineffective in transplant patients; therefore, clinicians should be very aware of those risks and carefully consider selection of agents and full disclosure of the risks to their patients.

  1. Clinical and Laboratory Responses of Cross-Country Skiing for a 24-H World Record: Case Report

    Directory of Open Access Journals (Sweden)

    Markus Niemelä, Jukka Juvonen, Päivikki Kangastupa, Onni Niemelä, Tatu Juvonen

    2015-12-01

    Full Text Available The physiological consequences of ultra-endurance cross-country skiing in cold conditions are poorly known. We report here clinical, echocardiographic and laboratory findings from a 41-y old male elite skier in a world record trial for 24-h skiing. The athlete completed a total of 406.8 km outdoors with the temperature ranging between -24°C and –5°C during the 24-h period. Post exercise, notable increases from baseline values were observed in myoglobin (50-fold, creatinine kinase (30-fold and proBNP (6-fold, whereas troponin T or troponin I levels remained unchanged. At baseline, echocardiographic findings showed cardiac hypertrophy and after skiing, a 5% reduction of left-ventricular end-diastolic dimension. Increases in markers of kidney (creatinine and liver function (alanine aminotransferase, serum uric acid, C-reactive protein and white blood cell counts were also noted. In addition, electrolyte disturbances including hyponatremia, hypophosphatemia and hypocalcaemia were noted during the follow-up. The data indicates that a prolonged period of high-intensity skiing leads to muscle, heart and kidney affection and activation of inflammation even in an experienced elite skier. The observed health effects underscore the need for strict medical surveillance of participants in extreme sports with long duration.

  2. Radiation recall gastritis secondary to combination of gemcitabine and erlotinib in pancreatic cancer and response to PPI - a case report.

    Science.gov (United States)

    Choi, Seong Ji; Kim, Hyo Jung; Kim, Jae Seon; Bak, Young-Tae; Kim, Jun Suk

    2016-08-02

    Radiation recall gastritis is rare but can be induced after concurrent chemoradiation for pancreatic cancer. We report a patient with pancreatic cancer who developed radiation-recall gastritis related to a combination of gemcitabine and erlotinib. A 54-year-old female with unresectable pancreatic cancer received gemcitabine in combination with radiation therapy followed by chemotherapy with gemcitabine and erlotinib. After completing 2 cycles of chemotherapy, the patient had epigastric pain, nausea, and vomiting. Abdominal computed tomography (CT) scan revealed diffuse wall thickening of the stomach, and esophagogastroduodenoscopy (EGD) showed multiple gastric ulcers. The patient was treated with proton pump inhibitors (PPI) and was continued on maintenance chemotherapy. Two months later, the patient presented with the similar symptoms and persistent gastric ulcers were observed during subsequent EGD. Nevertheless, the patient's symptom had resolved with PPI therapy. Thus, the patient underwent maintenance chemotherapy with gemcitabine and erlotinib for additional 4 cycles. Eventually, follow-up abdominal CT Scan and EGD at 6 months demonstrated resolution of the gastric ulcers. Physicians should be aware of the possibility of radiation recall gastritis associated with a combination of gemcitabine and erlotinib. Administration of PPIs may mitigate the adverse effects of gemcitabine and erlotinib in the presence of radiation recall gastritis; however further studies are warranted.

  3. Radiation recall gastritis secondary to combination of gemcitabine and erlotinib in pancreatic cancer and response to PPI - a case report

    International Nuclear Information System (INIS)

    Choi, Seong Ji; Kim, Hyo Jung; Kim, Jae Seon; Bak, Young-Tae; Kim, Jun Suk

    2016-01-01

    Radiation recall gastritis is rare but can be induced after concurrent chemoradiation for pancreatic cancer. We report a patient with pancreatic cancer who developed radiation-recall gastritis related to a combination of gemcitabine and erlotinib. A 54-year-old female with unresectable pancreatic cancer received gemcitabine in combination with radiation therapy followed by chemotherapy with gemcitabine and erlotinib. After completing 2 cycles of chemotherapy, the patient had epigastric pain, nausea, and vomiting. Abdominal computed tomography (CT) scan revealed diffuse wall thickening of the stomach, and esophagogastroduodenoscopy (EGD) showed multiple gastric ulcers. The patient was treated with proton pump inhibitors (PPI) and was continued on maintenance chemotherapy. Two months later, the patient presented with the similar symptoms and persistent gastric ulcers were observed during subsequent EGD. Nevertheless, the patient’s symptom had resolved with PPI therapy. Thus, the patient underwent maintenance chemotherapy with gemcitabine and erlotinib for additional 4 cycles. Eventually, follow-up abdominal CT Scan and EGD at 6 months demonstrated resolution of the gastric ulcers. Physicians should be aware of the possibility of radiation recall gastritis associated with a combination of gemcitabine and erlotinib. Administration of PPIs may mitigate the adverse effects of gemcitabine and erlotinib in the presence of radiation recall gastritis; however further studies are warranted

  4. A new reportable disease is born: Taiwan Centers for Disease Control's response to emerging Zika virus infection.

    Science.gov (United States)

    Huang, Angela Song-En; Shu, Pei-Yun; Yang, Chin-Hui

    2016-04-01

    Zika virus infection, usually a mild disease transmitted through the bite of Aedes mosquitos, has been reported to be possibly associated with microcephaly and neurologic complications. Taiwan's first imported case of Zika virus infection was found through fever screening at airport entry in January 2016. No virus was isolated from patient's blood taken during acute illness; however, PCR products showed that the virus was of Asian lineage closely related to virus from Cambodia. To prevent Zika virus from spreading in Taiwan, the Taiwan Centers for Disease Control has strengthened efforts in quarantine and surveillance, increased Zika virus infection diagnostic capacity, implemented healthcare system preparedness plans, and enhanced vector control program through community mobilization and education. Besides the first imported case, no additional cases of Zika virus infection have been identified. Furthermore, no significant increase in the number of microcephaly or Guillain- Barré Syndrome has been observed in Taiwan. To date, there have been no autochthonous transmissions of Zika virus infection. Copyright © 2016. Published by Elsevier B.V.

  5. Disposal of high-level radioactive wastes in the unsaturated zone: technical considerations and response to comments. Final report

    International Nuclear Information System (INIS)

    Hackbarth, C.J.; Nicholson, T.J.; Evans, D.D.

    1985-10-01

    On July 22, 1985, the US Nuclear Regulatory Commission (NRC) promulgated amendments to 10 CFR Part 60 concerning disposal of high-level radioactive waste (HLW) in geologic repositories in the unsaturated zone (50 FR 29641). This report contains a discussion of the principal technical issues considered by the NRC staff during the development of these amendments. It expands or revises certain technical discussions originally presented in draft NUREG-1046 (February 1984) based on public comment letters and an increasing understanding of the physical, geochemical, and hydrogeologic processes operative in unsaturated geologic media. The following issues related to disposal of HLW within the unsaturated zone are discussed: hydrogeologic properties and conditions, heat dissipation and temperature, geochemisty, retrievability, potential for exhumation of the radioactive waste by natural causes and by human intrusion, the effects of future climatic changes on the level of the regional water table, and transport of radionuclides in the gaseous state. The changes to 10 CFR Part 60 in definitions, siting criteria, and design criteria for the geologic repository operations area are discussed. Other criteria examined by the NRC staff but which were not changed in rule are the minimum 300-meter depth for waste emplacement, limitations on exploratory boreholes, backfill requirements, waste package design criteria, and provisions for ventilation

  6. Complete response in a patient with gynecological hidradenocarcinoma treated with exclusive external beam radiotherapy and brachytherapy: a case report.

    Science.gov (United States)

    Giannelli, Flavio; Chiola, Ilaria; Belgioia, Liliana; Garelli, Stefania; Pastorino, Alice; Marcenaro, Michela; Mammoliti, Serafina; Costantini, Sergio; Bizzarri, Nicolò; Vellone, Valerio; Barra, Salvina; Corvò, Renzo

    2017-12-01

    Hidradenocarcinoma (HC) is a very rare disease. This case report illustrates a successful treatment of a 60-year-old woman with vulvo-vaginal localization of hidradenocarcinoma treated with external beam radiotherapy delivered by helical tomotherapy with a simultaneous integrated boost (SIB), followed by brachytherapy. External beam radiotherapy dose prescription was 50.4 Gy in 28 fractions, five fractions per week to whole pelvis (planning target volume 1 - PTV1), 60.2 Gy in 28 fractions to SIB1 (fundus of uterus and right inguinal node), and 58.8 Gy in 28 fractions to SIB2 (lower/middle third of vagina, paraurethral region and right inguinal lymph nodes). Brachytherapy dose prescription was 28 Gy in 4 fractions for cervix, fundus of uterus and upper third of vagina (HR-CTV1), and 22 Gy in 4 fractions to middle third of vagina and paraurethral region (HR-CTV2). D 90 for whole treatment was 91.9 Gy and 86.0 Gy for HR-CTV1 and HR-CTV2, respectively. Patient remained 12-months disease-free without treatment related side effects.

  7. Complete response in a patient with gynecological hidradenocarcinoma treated with exclusive external beam radiotherapy and brachytherapy: a case report

    Directory of Open Access Journals (Sweden)

    Flavio Giannelli

    2017-12-01

    Full Text Available Hidradenocarcinoma (HC is a very rare disease. This case report illustrates a successful treatment of a 60-year-old woman with vulvo-vaginal localization of hidradenocarcinoma treated with external beam radiotherapy delivered by helical tomotherapy with a simultaneous integrated boost (SIB, followed by brachytherapy. External beam radiotherapy dose prescription was 50.4 Gy in 28 fractions, five fractions per week to whole pelvis (planning target volume 1 – PTV1, 60.2 Gy in 28 fractions to SIB1 (fundus of uterus and right inguinal node, and 58.8 Gy in 28 fractions to SIB2 (lower/middle third of vagina, paraurethral region and right inguinal lymph nodes. Brachytherapy dose prescription was 28 Gy in 4 fractions for cervix, fundus of uterus and upper third of vagina (HR-CTV1, and 22 Gy in 4 fractions to middle third of vagina and paraurethral region (HR-CTV2. D90 for whole treatment was 91.9 Gy and 86.0 Gy for HR-CTV1 and HR-CTV2, respectively. Patient remained 12-months disease-free without treatment related side effects.

  8. Fiscal year 1996 progress in implementing Section 120 of the Comprehensive Environmental Response, Compensation, and Liability Act. Tenth annual report to Congress

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-01

    Congress passed the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) (Public Law 96-510), commonly known as Superfund, in 1980. The Superfund Amendments and Reauthorization Act (SARA) (Public Law 99-499), which amended CERCLA in 1986, added Section 120 regarding the cleanup of contaminated sites at Federal facilities. Under Section 120(e)(5) of CERCLA, each department, agency, or instrumentality of the Federal government responsible for compliance with Section 120 must submit an annual report to Congress concerning its progress in implementing the requirements of Section 120. The report must include information on the progress in reaching Interagency Agreements (IAGs), conducting remedial investigation and feasibility studies (RI/FSs), and performing remedial actions. Federal agencies that own or operate facilities on the National Priorities List (NPL) are required to begin an RI/FS for these facilities within 6 months after being placed on the NPL. Remediation of these facilities is addressed in an IAG between the Federal agency, the US Environmental Protection Agency (EPA), and in some instances the state within which the facility is located.

  9. Diatom diversity and response in metal-polluted river environment: preliminary reports from Gromolo Torrent (Liguria, Italy)

    Science.gov (United States)

    Capello, Marco; Tolotti, Raffaella; Bernabè, Dimitri; Carbone, Cristina; Consani, Sirio; Vagge, Greta; Cutroneo, Laura

    2016-04-01

    Mineral content and physico-chemical properties of the freshwaters are the main factors affecting both algal assemblages and distributions, while presence of dissolved silicon, low water conductivity, and rocky-mountain habitats host benthic diatom assemblages of high species richness. It is shown that diatoms are sensible to the freshwater acidification (used as pH indicators in acid waters), environmental and climate changes, river organic load, and heavy metal water pollution. For this characteristic, diatoms are among the major biological markers for a variety of environmental and stratigraphic applications. In particular, qualitative and quantitative analyses (assemblage analyses) together with biotic indices as well as morphological and ultrastructure parameterisation provide tools for detailed environmental control and paleo-environmental reconstructions. Severe environmental problems are typically caused by "abandoned mine" and are consequences of the cessation of the mining activity with a lack in infrastructure maintenance. The mine waters which flow into the Gromolo Torrent are almost acidic (pH varying from 2.4 to 5) and enriched in heavy metals and SO42-. This pollution is caused by Acid Mine Drainage (AMD) processes that interest the Libiola mining area, known as a typical example of active AMD processes. The aim of this work is: 1) to characterise the local benthic diatom assemblages along the acidic mine effluents that discharge from Libiola mine, the entire Gromolo torrent course, and in the marine area off the torrent mouth; 2) to identify the main diatom biomarker taxa; 3) to highlight striking situations of equilibrium-disequilibrium in the algal communities, and 4) to point out types and frequency of some teratologies affecting specific diatom taxa as a response to environmental stressors (such as metal-metalloid enrichment). A total of 17 diatom samples was collected and examined, including some marine samples. Diatoms were collected in the

  10. Responses to comments received on the draft final report of the Secretary of Energy Advisory Board Task Force on Radioactive Waste Management

    Energy Technology Data Exchange (ETDEWEB)

    1994-10-01

    The Task Force solicited comments on its Draft Final Report from a variety of sources. Letters were sent to over 400 individuals who had expressed interest in the interest in the Department`s radioactive waste, management programs, a notice was placed in the Federal Register, the morning session of the January 1993 meeting of the full Secretary of Energy Advisory Board was given over to discussion of the draft, and Task Force members and staff presented the effort at several professional meetings. Altogether 32 written comments were received. They are reproduced here, followed in each case by the Task Force`s response to specific suggestions made to improve the draft. (The panel did not respond to comments that simply reflected policy preferences or that praised the group`s effort.) With one exception, those specific suggestions are highlighted and given a letter designation from {open_quotes}A{close_quotes} to {open_quotes}Z{close_quotes}. The Task Force`s responses, written in the Fall 1993, are labeled in a like manner. For the one exception, a comments submitted by Judy Treichel, the Task Force`s response is printed on copies of her annotated pages.

  11. Responses to comments received on the draft final report of the Secretary of Energy Advisory Board Task Force on Radioactive Waste Management

    International Nuclear Information System (INIS)

    1994-01-01

    The Task Force solicited comments on its Draft Final Report from a variety of sources. Letters were sent to over 400 individuals who had expressed interest in the interest in the Department's radioactive waste, management programs, a notice was placed in the Federal Register, the morning session of the January 1993 meeting of the full Secretary of Energy Advisory Board was given over to discussion of the draft, and Task Force members and staff presented the effort at several professional meetings. Altogether 32 written comments were received. They are reproduced here, followed in each case by the Task Force's response to specific suggestions made to improve the draft. (The panel did not respond to comments that simply reflected policy preferences or that praised the group's effort.) With one exception, those specific suggestions are highlighted and given a letter designation from open-quotes Aclose quotes to open-quotes Zclose quotes. The Task Force's responses, written in the Fall 1993, are labeled in a like manner. For the one exception, a comments submitted by Judy Treichel, the Task Force's response is printed on copies of her annotated pages

  12. Understanding the response of commercial and institutional organizations to the California energy crisis. A report to the California Energy Commission - Sylvia Bender, Project Manager

    Energy Technology Data Exchange (ETDEWEB)

    Lutzenhiser, Loren; Janda, Kathryn; Kunkle, Rick; Payne, Christopher

    2002-07-24

    Beginning in the summer of 2000, California experienced serious energy supply problems, sharp increases in wholesale (and retail) electricity and natural gas prices, and isolated blackouts. In response to the rapidly worsening electricity situation in California in late 2000, the state set, as an initial goal, the reduction of the state's peak demand for the summer of 2001 by 5,000 megawatts. To meet this goal, the governor and legislature took a variety of steps to enhance supply, encourage rapid voluntary reductions in demand, and provide incentives for actions that would result in load reductions. Three bills-Assembly Bill 970, Senate Bill X1 5 and Assembly Bill X1 29-allocated roughly $950 million for consumption and demand reduction programs. The governor also enacted a variety of additional measures, including the ''Flex Your Power'' (media awareness and direct business involvement) campaign, requirements for retail sector outdoor lighting reductions, and toughening of energy efficiency building codes. There were, in fact, significant reductions in electricity demand in California during the summer of 2001 and the large number of expected supply disruptions was avoided. To understand the nature of these demand reductions and the motivations for consumer response, Washington State University (WSU) undertook a study for the California Energy Commission (CEC) focusing on conservation behavior in the residential, commercial, and agricultural sectors. The research presented in this report represents an exploration of the response of commercial and institutional organizations to the California energy situation and the unique set of influences that existed during this time. These influences included informational messages and media attention, program interventions, price changes, and external triggering events (e.g., blackouts). To better understand the effects of these influences on organizational response to the energy situation, we

  13. Making sense of children's sexual behavior in child care: An analysis of adult responses in special investigation reports.

    Science.gov (United States)

    Martin, Karin A

    2014-10-01

    This paper investigates how adults respond to sexual behavior among children in child care. Culturally, childhood sexuality is variously understood as natural curiosity, a sign of sexual abuse, or a symptom of a sex-offender in the making. Given these competing cultural meanings, how are sexual-like behaviors by children managed by the adults who care for them? An analysis of qualitative data from Special Investigation Reports by childcare licensing consultants in the state of Michigan is used to examine how parents, child care providers, and child care licensing consultants manage and respond to sexual behavior between children in the context of child care. How sexual behavior is responded to depends primarily on who is doing the responding - parent, childcare provider, or state licensing consultant - rather than what type of behavior is being responded to. Parents respond to a wide range of behaviors between children as if they are incidents of sexual abuse. Childcare providers respond to many of those same incidents as misbehavior. Licensing consultants understand these incidents as violation of rules of supervision, but they were also the only group to ever ask if children's sexual behavior was potentially a sign of a child having been sexually abused in another setting. Providers and parents need more education about what kinds of sexual behavior to be concerned about and what kind to understand as common. More education that sexuality that is "rare" and persistent could be a sign of sexual abuse is needed by all parties. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Audit Report "Department of Energy Efforts to Manage Information Technology Resources in an Energy-Efficient and Environmentally Responsible Manner"

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-05-01

    The American Recovery and Reinvestment Act of 2009 emphasizes energy efficiency and conservation as critical to the Nation's economic vitality; its goal of reducing dependence on foreign energy sources; and, related efforts to improve the environment. The Act highlights the significant use of various forms of energy in the Federal sector and promotes efforts to improve the energy efficiency of Federal operations. One specific area of interest is the increasing demand for Federal sector computing resources and the corresponding increase in energy use, with both cost and environmental implications. The U.S. Environmental Protection Agency reported that, without aggressive conservation measures, data center energy consumption alone is expected to double over the next five years. In our report on Management of the Department's Data Centers at Contractor Sites (DOE/IG-0803, October 2008) we concluded that the Department of Energy had not always improved the efficiency of its contractor data centers even when such modifications were possible and practical. Despite its recognized energy conservation leadership role, the Department had not always taken advantage of opportunities to reduce energy consumption associated with its information technology resources. Nor, had it ensured that resources were managed in a way that minimized impact on the environment. In particular: (1) The seven Federal and contractor sites included in our review had not fully reduced energy consumption through implementation of power management settings on their desktop and laptop computers; and, as a consequence, spent $1.6 million more on energy costs than necessary in Fiscal Year 2008; (2) None of the sites reviewed had taken advantage of opportunities to reduce energy consumption, enhance cyber security, and reduce costs available through the use of techniques, such as 'thin-client computing' in their unclassified environments; and, (3) Sites had not always taken the

  15. Efficacy of sorafenib in BRAF-mutated non-small-cell lung cancer (NSCLC) and no response in synchronous BRAF wild type-hepatocellular carcinoma: a case report

    International Nuclear Information System (INIS)

    Casadei Gardini, Andrea; Chiadini, Elisa; Faloppi, Luca; Marisi, Giorgia; Delmonte, Angelo; Scartozzi, Mario; Loretelli, Cristian; Lucchesi, Alessandro; Oboldi, Devil; Dubini, Alessandra; Frassineti, Giovanni Luca; Ulivi, Paola

    2016-01-01

    Sorafenib is a multi-targeted kinase inhibitor with a demonstrated activity in renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC), and it is currently used for the treatment of these pathologies. Ongoing clinical trials are studying its activity in other malignancies, such as non-small-cell lung cancer (NSCLC). However, no biological marker is known to define either the sensitivity or resistance to the drug. Here we report a case of a patient with two synchronous tumors, HCC and NSCLC, with metastases in the contralateral lung and bone. The patient was treated with gemcitabine as first line, with a resulting progressive disease after two months, and then with sorafenib at standard dosage in the second line setting. After 6 months of treatment CT scan showed a partial response in the primary lesion of the lung, complete response of the metastasis in the contralateral lung, and stability of HCC. The patient had progression in the lung, liver and bone after 13 months of therapy. A molecular characterization of NSCLC and HCC lesions was performed, revealing a BRAF exon 11 mutation (G469V) only in NSCLC. We hypothesize that the response observed in NSCLC lesions could be due to the presence of BRAF mutation, and that this alteration could be responsible in determining sorafenib sensitivity. Results observed in this case encourage further research on the activity of sorafenib in both HCC and NSCLC, based on the presence of BRAF mutation. This could lead to a selection of HCC patients to be treated with this drug, and could help identify a novel treatment strategy for BRAF-mutated NSCLC patients

  16. Self-reported health and cortisol awakening response in parents of people with asperger syndrome: the role of trait anger and anxiety, coping and burden.

    Science.gov (United States)

    Ruiz-Robledillo, N; Moya-Albiol, L

    2013-11-01

    Caring for offspring with autism spectrum disorders entails high levels of stress for a long period of time and is associated with several types of health complaints. Few studies have focused on specific effects of particular disorders in the spectrum. This study was carried out with the aim of evaluating the global health of parents of people with Asperger syndrome (N = 53) compared to those of typically developing children (N = 54) through self-reported measures (medication consumption and somatic symptoms) and biological markers (cortisol awakening response [CAR]). Additionally, we analysed various psychological variables as potential predictors of caregiver health. We found that caregivers take more medication and have worse self-reported health than controls, but there were no significant differences in CAR between the groups. However, after controlling for negative affect, differences between groups in CAR reached significance. With regards to predictor variables, anxiety trait, cognitive-coping style, burden and anger temperament were significantly associated with caregiver's self-reported health. These findings underline the need to develop interventions that foster improvements in the health of caregivers, reduce their burden and enhance their quality of life.

  17. Interactions of CO{sub 2} with temperature and other climate variables: Response of vegetation. Final report, September 1, 1988--August 31, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Acock, B.; Kimball, B.A.

    1995-02-01

    The current project was initiated in 1991, and full details of the scope of the project are contained in the original proposal. that original proposal was reviewed and approved for three years funding. Progress made in 1991-92 and 1992-93 was described in annual Progress Reports and Statements of Work. This document summarizes progress made over the duration of the project, but with an emphasis on the final year`s (1993-94) results. Several of the important experiments are ongoing, to the extent that alternative funding could be arranged, and analyses of data from several of the earlier completed experiments is continuing. Therefore, this Final Report is also intermediary in nature, and additional results from this project will be reported in the open literature in the future. The overall objectives of the project were: (1) to examine experimentally, for major crop species, the interacting effects of CO{sub 2} concentration, temperature, and water availability on plant growth and development, (2) to model these interactions, and (3) to continue developing physiologically-based mechanistic models for predicting crop response to increased CO{sub 2} concentration and future global climate change.

  18. Evaluating the correlation and responsiveness of patient-reported pain with function and quality-of-life outcomes after spine surgery.

    Science.gov (United States)

    DeVine, John; Norvell, Daniel C; Ecker, Erika; Fourney, Daryl R; Vaccaro, Alex; Wang, Jeff; Andersson, Gunnar

    2011-10-01

    Systematic review. To determine the correlation of patient-reported pain with physical function and health-related quality of life (HRQoL) after spine surgery and to determine the responsiveness of pain, physical function, and HRQoL after spine surgery. Several validated outcome instruments are available to assess the success of treatment for chronic low back pain. These patient-centered tools include measurements for pain based on numeric scales, validated condition-specific functional outcomes measures, and HRQoL outcomes measures. It is unclear whether these three types of patient-reported outcomes are measuring different constructs and whether all three should be measured after spine surgery. In addition, it is unclear which of these outcomes measures is most sensitive to change after spine surgery for low back pain. A systematic search was conducted in MEDLINE, EMBASE, and the Cochrane Collaboration Library for literature published through December 2010. The correlation between pain (visual analog scale, VAS), physical function (Oswestry Disability Index, ODI), and HRQoL (36-Item Short Form Health Survey [SF-36] and European Quality of Life [EQ-5D]) change scores was performed using the Spearman rank correlation coefficients. To compare the responsiveness of pain, function, and HRQoL scores after spine surgery, we calculated effect sizes by dividing change scores by the SD of the baseline scores. This standardized method allowed us to compare the responsiveness of each outcome measure directly and reported an effect size of 0.2 to 0.3 as a "small" effect, around 0.5 a "medium" effect and 0.8 to infinity, a "large" effect. To determine whether the differences in effect sizes measuring responsiveness were significantly different, we conducted a Wilcoxon signed-rank test between each of the three measurements of pain, function, and HRQoL scores when there was enough data to perform the test. None of the correlations exceeded 0.70 using the Spearman rank

  19. Use of transgenic GFP reporter strains of the nematode Caenorhabditis elegans to investigate the patterns of stress responses induced by pesticides and by organic extracts from agricultural soils.

    Science.gov (United States)

    Anbalagan, Charumathi; Lafayette, Ivan; Antoniou-Kourounioti, Melissa; Gutierrez, Carmen; Martin, Jose Rodriguez; Chowdhuri, Debapratim K; De Pomerai, David I

    2013-01-01

    As a free-living nematode, C. elegans is exposed to various pesticides used in agriculture, as well as to persistent organic residues which may contaminate the soil for long periods. Following on from our previous study of metal effects on 24 GFP-reporter strains representing four different stress-response pathways in C. elegans (Anbalagan et al. Ecotoxicology 21:439-455, 2012), we now present parallel data on the responses of these same strains to several commonly used pesticides. Some of these, like dichlorvos, induced multiple stress genes in a concentration-dependent manner. Unusually, endosulfan induced only one gene (cyp-34A9) to very high levels (8-10-fold) even at the lowest test concentration, with a clear plateau at higher doses. Other pesticides, like diuron, did not alter reporter gene expression detectably even at the highest test concentration attainable, while others (such as glyphosate) did so only at very high concentrations. We have also used five responsive GFP reporters to investigate the toxicity of soil pore water from two agricultural sites in south-east Spain, designated P74 (used for cauliflower production, but significantly metal contaminated) and P73 (used for growing lettuce, but with only background levels of metals). Both soil pore water samples induced all five test genes to varying extents, yet artificial mixtures containing all major metals present had essentially no effect on these same transgenes. Soluble organic contaminants present in the pore water were extracted with acetone and dichloromethane, then after evaporation of the solvents, the organic residues were redissolved in ultrapure water to reconstitute the soluble organic components of the original soil pore water. These organic extracts induced transgene expression at similar or higher levels than the original pore water. Addition of the corresponding metal mixtures had either no effect, or reduced transgene expression towards the levels seen with soil pore water only. We

  20. Attendance Patterns and Links to Non-Response on Child Report of Internalizing among Mexican-Americans Randomized to a Universal Preventive Intervention.

    Science.gov (United States)

    Mauricio, Anne M; Tein, Jenn-Yun; Gonzales, Nancy A; Millsap, Roger E; Dumka, Larry E

    2018-02-01

    We examined attendance trajectory profiles among 335 Mexican-American families participating in an 11-week universal intervention to explore if heterogeneity in attendance and thus dosage was associated with intervention response, defined as pre-to-2-year post (T2) reductions in child report of internalizing symptoms. We estimated trajectories accounting for the influence of baseline covariates, selected based on the Health Belief Model (HBM) and Latino family research, to understand covariate associations with trajectories. Results supported six attendance trajectory groups: non-attenders (NA), early dropouts-low internalizing (EDO-LI), early dropouts-high internalizing (EDO-HI), mid-program dropouts (MPDO), sustained attenders-low internalizing (SA-LI), and sustained attenders-high internalizing (SA-HI). All groups except EDO-HI showed significant pre-to-post change on child report of internalizing; however, trajectory groups reflecting more attendance did not have greater pre-to-post change. Nonetheless, child report of internalizing differentiated two subgroups of sustained attenders and two subgroups of early dropouts. These results suggest heterogeneity among families with similar patterns of attendance and highlight the importance of modeling this heterogeneity. Although life stress was a barrier to participation, there was minimal support for the HBM. Cultural influences, acculturation, and familism, played a more prominent role in distinguishing trajectories. As expected, the EDO-HI group was less acculturated than both sustained attender groups and reported weaker familism values than the SA-HI group. However, unexpectedly, the SA-LI group had lower familism than the EDO-LI group. The results suggest that the influence of culture on participation is nuanced and may depend on child symptomatology.