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Sample records for bazo errante torcido

  1. Bazo errante torcido: Presentación de dos casos Twisted wandering spleen

    OpenAIRE

    Diego Maldonado M; Richard López C

    2006-01-01

    El bazo errante torcido es una causa poco frecuente de abdomen agudo en el niño. Se caracteriza por una ausencia o hiperlaxitud de los ligamentos esplénicos, con el riesgo de torsión de su pedículo y necrosis. El objetivo de la presente revisión es reportar dos casos de bazo errante torcido manejados en el Servicio de Cirugía Pediátrica del Hospital Clínico San Borja Arriarán y discutir las opciones de tratamiento. Ambos casos debutaron como abdomen agudo, fueron operados con diagnóstico de a...

  2. La medición del bazo en la Malaria

    Directory of Open Access Journals (Sweden)

    L. W. Hackett

    1943-12-01

    Full Text Available El análisis de los datos recogidos en el examen de bazos agrandados y parásitos de malaria en unas 40,000 personas en Italia y Albania durante un período de años, revela algunos hechos interesantes, en cuanto a la relativa importancia de los hallazgos del bazo y sangre, para juzgar una situación endémica. Más del 97 por, ciento de la malaria endémica, fue descubierto por el examen del bazo solamente. La importancia del examen del bazo es tal, tanto para avaluar los resultados de las medidas de control de año a año. como para comparar una área con otra en cuanto a la intensidad de la malaria, que la aceptación de un método patrón para examinar los bazos y anotar sus tamaños, marcaría un gran progreso en la investigación de la malaria y en nuestra capacidad para interpretar las observaciones de otros investigadores publicadas en todo el mundo. Se ha descrito un método simplificado, el cual ha resistido la prueba del tiempo y de los estadísticos en muchos países.

  3. Geological prospecting in La Primera area (Caballo Torcido) Fotoplano M-25 Mal Abrigo San Jose town

    International Nuclear Information System (INIS)

    This work describes the prospection results in La Primera (Caballo Torcido) area in San Jose town. In this zone has been extracted metallic minerals, sediments and multielement soil samples to detect geochemical anomalies.

  4. PREVALÊNCIA DE ENDOPARASITAS EM CÃES ERRANTES NA CIDADE DE MANAUS-AM

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    Geraldo PEREIRA JUNIOR

    2015-12-01

    Full Text Available Objetivou-se determinar a prevalência de endoparasitas em cães errantes na cidade de Manaus-AM. Foram coletadas amostras de fezes de 80 cães errantes nas feiras municipais das zonas: Norte, Leste, Sul e Centro, da cidade de Manaus-Am. Para o diagnóstico coproparasitológico as amostras foram utilizados os métodos de Willis-Mollay e centrífugo- flutuação em solução saturada de sacarose. Todas as amostras foram positivas para a presença de endoparasitas, sendo o Ancylostoma sp. o de maior prevalência (85%. O estudo demonstrou à elevada disseminação das parasitoses intestinais de cães errantes na cidade de Manaus.

  5. O andarilho e o romântico: o mito do Judeu Errante em Castro Alves

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    Kenia Maria de Almeida Pereira

    2014-11-01

    Full Text Available O poema “Ahasverus e o gênio”, de Castro Alves dá relevo à lenda do Judeu Errante. Este artigo analisará esse poema e outros textos que apresentem temas judaicos. Levaremos também em consideração alguns estudos anteriores que retomam as questões românticas relacionadas ao poeta gênio e vate de um povo.

  6. Errant polychaetes of the continental plattaform of Tamaulipas, México.

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    V. Hugo Delgado-Blas

    2014-06-01

    Full Text Available 24 species of errant polychaetes have been recorded for the eastern Mexican continental shelf: Two Phyllodocidae, one Pilargidae, two Syllicdae, four Nereididae, two Glyceridae, two Goniadidae, three Nephtyidae, two Onuphidae, five Lumbrineridae y one Dorvilleidae. Two of these were the first to be recorded in Mexico, two from Mexican waters in the Gulf of Mexico and 11 new ones recorded in Tamaulipas.

  7. Errant paths

    DEFF Research Database (Denmark)

    Pinder, David

    2011-01-01

    current realities, especially in the context of the regulated, fortified, and surveilled zones of London. Addressing the poetics and politics of his spatial practices, however, reveals the inadequacy of undifferentiated models of creative resistance, nomadism, and subversion beloved of much recent theory...

  8. Estudo observacional transversal de parasitas em cães errantes no concelho de Vila Franca de Xira, Portugal

    OpenAIRE

    Santos, João Pedro Gibert Alvarez Bettencourt dos

    2014-01-01

    Os animais errantes são uma população particularmente importante em medicina veterinária, permitindo a manutenção dos agentes no biótopo e a dispersão para áreas não endémicas. Esta população tem vindo a aumentar, por todo o mundo, sendo fácil o seu contacto, quer directo quer indirecto com o Homem. Este trabalho foi elaborado com a intenção de pesquisar parasitas de vários órgãos, sistemas e localizações, na população de cães errantes do concelho de Vila Franca de Xira, Portugal, utilizan...

  9. Pseudomonas aeruginosa outbreak in a pediatric oncology care unit caused by an errant water jet into contaminated siphons.

    Science.gov (United States)

    Schneider, Henriette; Geginat, Gernot; Hogardt, Michael; Kramer, Alexandra; Dürken, Matthias; Schroten, Horst; Tenenbaum, Tobias

    2012-06-01

    We analyzed an outbreak of invasive infections with an exotoxin U positive Pseudomonas aeruginosa strain within a pediatric oncology care unit. Environmental sampling and molecular characterization of the Pseudomonas aeruginosa strains led to identification of the outbreak source. An errant water jet into the sink within patient rooms was observed. Optimized outbreak management resulted in an abundance of further Pseudomonas aeruginosa infections within the pediatric oncology care unit. PMID:22333699

  10. Fail-safe ion chamber errant beam detector tailored for personnel protection

    International Nuclear Information System (INIS)

    This fail-safe ion chamber system is designed to be part of the personnel safety system (PSS) for the Los Alamos neutron Scattering Center (LANSCE) at the Los Alamos National Laboratory. Its job is to protect the occupants of the experimental areas from large radiation doses caused by errant beam conditions during beam transport from the Proton Storage Ring (PSR) to the LANSCE neutron spallation target. Due to limited shielding between the beam transport line and the experimental area only if the beam losses in the transport line are very low. The worst case beam spill scenario is calculated to result in a personnel exposure of about 0.01 Gys/s (1 rad/s). Although the preferred solution is to increase the bulk shielding between the beam line and the experimental area, the physical dimensions of the site do not permit an adequate amount of shielding to be added. The solution adopted is a layered system of three types of highly reliable detector systems: a current limiter system located in the beam line, a neutron detector system located in the experimental areas, and an ion chamber system located on the walls of the beam line tunnels. The ion chamber system is capable of shutting off the beam in less than 0.5 s, resulting in a worst case personnel exposure of 0.005 Gys (0.5 rad). 4 figs

  11. Fail-safe ion chamber errant beam detector tailored for personnel protection

    International Nuclear Information System (INIS)

    This fail-safe ion chamber system is designed to be part of the personnel safety system (PSS) for the Los Alamos Neutron Scattering Center (LANSCE) at the Los Alamos National Laboratory. Its job is to protect the occupants of the experimental areas from large radiation doses caused by errant beam conditions during beam transport from the Proton Storage Ring (PSR) to the LANSCE neutron spallation target. The worst case beam spill scenario is calculated to result in a personnel exposure of about 0.01 Gys/s (1 rad/s). Although the preferred solution is to increase the bulk shielding between the beam line and the experimental area, the physical dimensions of the site do not permit an adequate amount of shielding to be added. The solution adopted is a layered system of three types of highly reliable detector systems: a current limiter system located in the beam line, a neutron detector system located in the experimental areas, and an ion chamber system located on the walls of the beam line tunnels. The ion chamber system is capable of shutting off the beam in less than 0.5 s, resulting in a worst case personnel exposure of 0.005 Gys (0.5 rad). 4 figs

  12. Obstrucción intestinal secundaria a vólvulo espléndico en un paciente pediátrico

    Directory of Open Access Journals (Sweden)

    Juan Pablo Murillo-Ortiz

    2005-10-01

    Full Text Available La torsión de un bazo errante es rara. La forma de presentación varia desde dolor abdominal intermitente hasta un cuadro de abdomen agudo. Se presenta un caso clínico de un paciente pediátrico con obstrucción intestinal secundaria a la torsión de un bazo errante

  13. Exame parasitológico de fezes de gatos (Felis catus domesticus domiciliados e errantes da Região Metropolitana do Rio de Janeiro, Brasil

    Directory of Open Access Journals (Sweden)

    Serra Cathia Maria Barrientos

    2003-01-01

    Full Text Available Foram estudadas 131 amostras de fezes de gatos de comportamento domiciliado e errante da Região Metropolitana do Rio de Janeiro, obtendo-se uma positividade de 63,4% das amostras, com maior ocorrência no grupo de animais errantes. Foi observado predomínio de parasitismo por Ancylostoma sp (43,5%, Toxocara sp (19,1% e Cystoisospora sp (43,5% em ambos os grupos. Também foram encontrados ovos de Uncinaria sp (1,5%, Toxascaris leonina (7,6%, cistos de Giardia sp (6,1% e esporocistos de Sarcocystis sp (0,8%. A alta prevalência de enteroparasitas na amostra estudada ressalta a importância de um maior controle parasitológico nesses animais, para proteção da saúde animal e humana.

  14. Obstrucción intestinal secundaria a vólvulo espléndico en un paciente pediátrico

    OpenAIRE

    Juan Pablo Murillo-Ortiz; Marco V Vargas-Salas

    2005-01-01

    La torsión de un bazo errante es rara. La forma de presentación varia desde dolor abdominal intermitente hasta un cuadro de abdomen agudo. Se presenta un caso clínico de un paciente pediátrico con obstrucción intestinal secundaria a la torsión de un bazo erranteThe occurrence of a wandering spleen is unusual, and even more a tortioned wandering spleen. The patients may present with various syrnptoms ranging from mild intermittent abdominal pain to an acute abdomen. We present a patient with i...

  15. Errância e normalização social: um estudo sobre andarilhos de estrada Errantes y normalización social: un estudio sobre andariegos de carretera Wandering and social normalization: a study about highway wanderers

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    Eurípedes Costa do Nascimento

    2009-12-01

    Full Text Available O nomadismo contemporâneo associado à migração, pobreza, desemprego e desfiliação social é uma característica marcante de nosso tempo e se expressa com maior radicalidade no fenômeno da errância, compreendida por uma perambulação a pé do indivíduo pelas rodovias, sem rumo certo e destino definido. O presente artigo tem por objetivo analisar a relação entre a errância e a normalização social, tendo como foco de análise o caso dos andarilhos de estrada.El nomadismo contemporáneo articulado con la migración, pobreza, desempleo y desafiliación social es una característica común de nuestro tiempo y puede ser percibido radicalmente en el fenómeno de los errantes, sujetos que son conocidos por caminaren a pie por las carreteras, sin rumbo cierto y destino definido. Ese artículo procura analizar la relación entre los errantes y la normalización social eligiendo como foco de análisis el caso de los andariegos de carretera.The contemporary nomadic life related to migration, poverty, unemployment and social disaffiliation is a common characteristic of our time and it can be seen radically in the wandering phenomenon understood as a displacement on foot of the individual through the highways without certain course and no definite destination. The present paper aims to analyze the relation between the wandering and the social normalization being the highway wanderers the main analysis focus.

  16. Pseudoplaquetopenia em paciente submetida à esplenectomia de baço acessório: relato de caso Pseudoplaquetopenia en paciente sometida a la esplenectomía de bazo accesorio: relato de caso Pseudothrombocytopenia in a patient undergoing splenectomy of an accessory spleen: case report

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    Eduardo Jorge Yamada

    2008-10-01

    por milímetro cúbico. El objetivo de este relato fue presentar el caso de una paciente que presentaba un número de plaquetas extremadamente bajo cuando su muestra de sangre era analizada en un tubo con EDTA y un número normal cuando se analizaba con citrato, avisando sobre el riesgo de la administración equivocada de hemoderivados. RELATO DEL CASO: Paciente del sexo femenino, 40 años, ASA II. En 2001, presentó plaquetopenia en el hemograma y fue llevada al hematólogo en Manaus, estado brasileño de Amazonas, siendo realizada la esplenectomía en ese mismo año, con diagnóstico de púrpura trombocitopénica idiopática. Al continuar la plaquetopenía en los hemogramas se verificó en la ecografía de abdomen: imagen hipoecoica de ecotextura similar a la esplénica, midiendo 2,0 × 1,7 cm, forma esférica, contenido bien definido (bazo accesorio e indicada esplenectomía de bazo accesorio. Después de una hora de operación, se recogieron muestras para hemograma y bioquímica: Hb = 11,3 g.dL-1; Ht = 33,4%; Plaquetas = 35.000.µL-1; TAP = 15,2 (86,0% Actividad (RNI = 1,09. Debido al sangramiento mínimo en el campo quirúrgico, fue solicitado un nuevo examen con citrato para la dosificación de plaquetas (resultado: 138.000 plaquetas. CONCLUSIONES: El resultado anómalo en un examen aislado en correspondencia con la clínica del paciente, no debe ser el leitmotiv de la terapéutica. Todos los exámenes poseen un porcentaje definido de errores, y la búsqueda de esos errores técnicos impide que una terapéutica equivocada sea usada.BACKGROUND AND OBJECTIVES: Coagulation tests (CBC and prothrombin time were initially conceived as a mean of screening and following rare congenital coagulopathies; the CBC provides the number of platelets per cubic milliliter. The objective of this report was to present the case of a patient who presented with an extremely low number of platelets when her blood was analyzed in an EDTA-containing tube and its numbers were normal when

  17. Populações de aranhas errantes do gênero Ctenus em fragmentos florestais na Amazônia Central Populations of Ctenus wandering spiders in Amazonian forest fragments

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    Luiz Augusto Macedo Mestre

    2008-01-01

    Full Text Available Ctenus é um gênero de aranhas errantes abundante em florestas tropicais da América do Sul e da África e está se tornando um organismo modelo para compreensão da biologia de predadores na fauna de serapilheira. Avaliamos os efeitos da fragmentação florestal sobre quatro espécies de aranhas errantes do gênero Ctenus (C. amphora, C. crulsi, C. manauara e C. villasboasi, baseado nas variações das densidades e nos tamanhos de adultos em fragmentos de tamanhos diferentes, nas bordas destes e nas florestas secundárias próximas. Este estudo foi realizado de fevereiro a julho de 1999, em floresta tropical úmida de terra firme ao norte de Manaus - AM. As áreas incluíram três locais de mata secundária, quatro fragmentos de 1 ha, três de 10 ha, dois de 100 ha e quatro reservas em floresta contínua (maior que 10.000 ha. As aranhas foram capturadas manualmente, mensuradas e contadas em transectos de 250x5 m ou 500x5 m em áreas de platô, no interior e nas bordas dos fragmentos. Houve predomínio significativo de fêmeas em duas espécies (C. amphora- 74% e C. crulsi- 65%; dimorfismo sexual de tamanho em três espécies (C. amphora, C. crulsi e C. manauara e variação temporal da abundância significativa para as quatro espécies. Estes resultados corroboraram e complementaram tendências de estudos anteriores e permitem uma interpretação mais completa sobre a ecologia destas espécies. Não observamos diferenças de abundância das aranhas entre centro e bordas e entre reservas de diferentes tamanhos. O efeito de borda ou do tamanho do fragmento sobre o tamanho de aranhas Ctenus neste estudo foi bem menor que as variações anteriormente observadas entre habitats diferentes no interior da floresta. Comparações com um estudo posterior a este, mostram que efeito da fragmentação nesta escala sobre estas aranhas diminui com a regeneração da floresta ao redor dos fragmentos, indicando uma rápida resposta do grupo para estas modifica

  18. Human enterovirus infection in stray dogs. Some aspects of interest to public health Infecção por enterovirus humanos em cães errantes. Alguns aspectos de interesse em Saúde Pública

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    Eliseu Alves Waldman

    1996-04-01

    Full Text Available To investigate the possible role of domestic animals as reservoirs of human enteroviruses, we studied 212 stray dogs captured in different areas of the municipality of São Paulo. The captured animals were divided into 19 groups of 10 to 20 dogs each; faeces of 126 of the 212 dogs were processed for enterovirus isolation. The following viruses were isolated from 12 dogs: poliovirus type 1 (2 dogs, poliovirus type 3 (1 dog, echovirus type 7 (8 dogs and echovirus type 15 (1 dog. Of the 12 infected animals, four had specific homotypic neutralizing antibody titres > 16. All 212 animals were tested for the presence of neutralizing antibodies to human enteroviruses. The frequency of neutralizing antibodies present in titres of > 16 was 10.3%, 3,8% and 4.3% for vaccinal prototypes of polioviruses 1, 2 and 3 respectively; 1,9%, 1.4% and 1.5% for wild prototypes of the same viruses, 11.3% for echovirus 7, and 2.4% for echovirus 15. The proportion of dogs with neutralizing antibodies varied with the virus studied. Some indication of the susceptibility of dogs to infection with human enteroviruses was demonstrated, and the importance of this fact for the Plan for Global Eradication of the Wild Poliovirus is discussed.Foram estudados 212 cães errantes, capturados em áreas periféricas do município de São Paulo, com o objetivo de investigar o possível papel desses animais como reservatórios de enterovírus humanos. Os animais capturados foram divididos em 19 grupos compostos por 10 a 20 animais cada um. Foram efetuadas tentativas de isolamento em amostras de fezes em 126/212 cães, obtendo-se resultados positivos em 12 deles, assim distribuídos: poliovirus tipo 1 (dois cães, poliovírus tipo 3 (um cão, echovirus tipo 7 (oito cães e echovirus tipo 15 (um cão. Dos 12 animais infectados, quatro apresentaram anticorpos neutralizantes homotípicos com títulos > 16. Todos os 212 cães foram submetidos a pesquisa de anticorpos neutralizantes contra

  19. Prevalência de Echinococcus granulosus (Batsch, 1786) em cães urbanos errantes do município de Dom Pedrito (RS), Brasil Prevalence of Echinococcus granulosus (Batsch, 1786) in urban stray dogs from Dom Pedrito in the State of Rio Grande do Sul, Brazil

    OpenAIRE

    Adriane Nunes Hoffmann; Ramiro Malgor; Mário Luiz de la Rue

    2001-01-01

    Echinococcus granulosus é um dos parasitas mais importantes envolvidos em zoonoses de municípios próximos a fronteira do Rio grande do Sul com a Argentina e Uruguai. Amostras de 65 cães urbanos errantes do município de Dom Pedrito foram analisadas por meio de três técnicas: purgação pelo bromidrato de arecolina para visualização da presença do parasito; ensaio de imunoadsorção enzimática (ELISA), para detecção de coproantígenos, imunofluorescência indireta (IFI), para detecção de anticorpos s...

  20. Prevalência de Echinococcus granulosus (Batsch, 1786 em cães urbanos errantes do município de Dom Pedrito (RS, Brasil Prevalence of Echinococcus granulosus (Batsch, 1786 in urban stray dogs from Dom Pedrito in the State of Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Adriane Nunes Hoffmann

    2001-10-01

    Full Text Available Echinococcus granulosus é um dos parasitas mais importantes envolvidos em zoonoses de municípios próximos a fronteira do Rio grande do Sul com a Argentina e Uruguai. Amostras de 65 cães urbanos errantes do município de Dom Pedrito foram analisadas por meio de três técnicas: purgação pelo bromidrato de arecolina para visualização da presença do parasito; ensaio de imunoadsorção enzimática (ELISA, para detecção de coproantígenos, imunofluorescência indireta (IFI, para detecção de anticorpos séricos contra E. granulosus. Destes cães, 7,7% (5/65 apresentaram o parasita nas fezes, 10,8 (7/65 coproantígenos e 13,8% (9/65 anticorpos séricos contra o cestódeo. Conclui-se que a equinococose canina, no meio urbano, pode representar um sério problema à saúde pública, devido ao risco de hidatidose humana.Echinococcus granulosus is the one of the most important parasites involved in zoonosis in the State of Rio Grande do Sul, in cities near the Argentinian and Uruguayian border. Sixty-five samples of urban stray dogs from Dom Pedrito county were analyzed by three techniques: purgation by arecoline hydrobromide, to verify the presence of the parasite; enzyme-linked immunosorbent assay test (ELISA, to detect the coproantigen and indirect immunofluorescence antibody test (IFA to identify serum antibodies against E. granulosus. From the analyzed dogs 7.7% (5/65 have presented the parasite in feces, 10.8% (7/65 had coproantigens and 13.8% (9/65 serum antibodies against this cestode. It was concluded that canine echinococcosis in the urban zone may represent a serious problem to public health, due to hidatidosis risk for humans.

  1. Thomas C. Schelling: la paradoja de un economista errante

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    Boris Salazar

    2007-12-01

    Full Text Available Este artículo explica dos enigmas asociados a la carrera científica de Thomas C. Schelling, premio Nobel de Economía 2005: ¿cómo explicar su capacidad para producir nuevas ideas?, y ¿por qué sus ideas precursoras han tenido más impacto en otras ciencias sociales y no en la economía? A los que responde con tres hipótesis: la poca influencia del conocimiento heredado en su trabajo teórico, una heurística que privilegió siempre la relación entre hechos inéditos y ángulos inusuales, y la creación de una red de conocimiento espontánea que entrelazó diversas disciplinas dedicadas al estudio de la interacción social.

  2. Falsification, Annual Targets, and Errant Leadership: Media Portrayal of the Atlanta Test-Cheating Scandal

    Science.gov (United States)

    Freeman, Eric

    2015-01-01

    This analysis of the Atlanta test-cheating scandal differs markedly from the version reported in the press. Using discourse analysis, I examined over 50 articles published in the "Atlanta Journal-Constitution" ("AJC"), the hometown newspaper at the center of the investigation. Because newspapers are a primary source of…

  3. Paul Ludwing Landsberg, a Knight Errant of the Spirit in Barcelona

    OpenAIRE

    Escribano, Xavier

    2015-01-01

    Paul Ludwig Landsberg (Bonn, 1901-Oranienburg, 1944) was a prominent student of the German philosopher Max Scheler. Born into a Jewish family, Landsberg was a professor at the University of Bonn until 1933, when he left his country at the time of Hitler’s rise to power. In spring 1934, Joaquim Xirau, dean of the Faculty of Philosophy and Letters of the University of Barcelona, invited him to give lectures and teach classes in the Seminar on Education. During the academic years 1934-35 and 193...

  4. El ropero torcido del extraño Augusto d’Halmar: Escritura y homoerotismo en Chile a comienzos del siglo XX

    Directory of Open Access Journals (Sweden)

    Victor Rocha Monsalve

    2013-08-01

    Full Text Available La irrupción del deseo homoerótico y su posibilidad de inscripción en una subjetividad en la sociedad chilena se encuentra vinculada a dos procesos que definirían la experiencia histórica durante la primera mitad del siglo XX. Por un lado, la llamada “cuestión social” con sus discursos de crisis del proyecto estatal ilustrado y, de otro, las nuevas sensibilidades literarias, se constituyeron paradójicamente en el soporte de las fantasías y ansiedades creadas por la modernización. Soportes sociales y materiales discursivos que a su vez coincidieron con la problematización de las fronteras genérico-sexuales y las identidades deseables que debían integrar la comunidad imaginada de la nación, en tanto, asociación limitada y soberana, siguiendo la propuesta de Benedict Anderson, vinculada por medio de lazos fraternales homosociales que daban cuenta de su carácter hegemónico como excluyente frente a lo considerado diverso como lo hibrido.

  5. Navegaciones errantes. De músicas, jóvenes y redes: de Facebook a Youtube y viceversa

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    Rossana Reguillo

    2012-01-01

    Full Text Available Este artículo analiza --desde una perspectiva sociocultural--, la relación entre música y culturas juveniles a partir de la mediación de las redes sociales digitales y la tecnología. Fundamentado en una investigación exploratoria en línea, el artículo es más un ensayo en torno a posibles líneas de indagación y la generación de nuevas preguntas, que un reporte. Se exploran algunas de las transformaciones en las culturas musicales juveniles en sus vínculos con la tecnología.

  6. Metodología para la implementación de un sistema de gestión de los costos de calidad en la industria del tabaco torcido

    OpenAIRE

    Julio César Gámez Ricardo

    2011-01-01

    Se planteó que en Cuba, la búsqueda de mayores resultados económicos y sociales es fundamental en el sector empresarial, insertada en un entorno complejo y dinámico, donde la calidad debe jugar un papel estratégico. Se dieron pasos importantes en la implementación de sistemas de gestión de la calidad y con ello fue necesario tener claro el aspecto financiero o económico de la calidad, por lo cual se diseñó una metodología para la implementación de un sistema de gestión de los costos de la cal...

  7. Metodología para la implementación de un sistema de gestión de los costos de calidad en la industria del tabaco torcido

    Directory of Open Access Journals (Sweden)

    Julio César Gámez Ricardo

    2011-01-01

    Full Text Available Se planteó que en Cuba, la búsqueda de mayores resultados económicos y sociales es fundamental en el sector empresarial, insertada en un entorno complejo y dinámico, donde la calidad debe jugar un papel estratégico. Se dieron pasos importantes en la implementación de sistemas de gestión de la calidad y con ello fue necesario tener claro el aspecto financiero o económico de la calidad, por lo cual se diseñó una metodología para la implementación de un sistema de gestión de los costos de la calidad, con el objetivo de contribuir a optimizar los mismos y para la mejora continua en las organizaciones.

  8. Mundos Torcidos: diferenças entre crioulos e africanos na dinâmica da construção de comunidades de grandes propriedades no Sudeste brasileiro do século XIX.

    OpenAIRE

    Carlos Engemann

    2015-01-01

    Este trabalho tem como objetivo identificar e analisar elementos constitutivos das relações entre grupos de escravos oriundos da diáspora africana e seus pares nascidos no Brasil, em busca de um padrão cultural e de fundamentos morais que organizariam as diferenças instauradas no cativeiro, buscando compreender um pouco mais a dinâmica do manuseio de patrimônios imateriais, quer trazidos na travessia do Atlântico, quer produzidos nas senzalas brasileiras. Para tanto, foram selecionados, por s...

  9. Linfoma marginal del bazo asociado a acidosis láctica tipo B: Caso clínico Type B lactic acidosis associated with marginal lymphoma of the spleen: Report of one case

    OpenAIRE

    Jorge Vega; María de los Ángeles Rodríguez; Armando Peña; Alejadro Vásquez

    2012-01-01

    Lactic acidosis in the absence of hypoxia or tissue hypoperfusion (type B) is very rare and is associated with the use of some drugs or malignancy. We report a 79-year-old woman, with a marginal non-Hodgkin's lymphoma of the spleen that was subjected to a splenectomy one year ago. She presented with unexplained tachypnea associated with pancytopenia and elevation of IgM to 10 times over the higher normal limit. Laboratory tests showed the presence of metabolic acidosis and high lactic acid le...

  10. Linfoma marginal del bazo asociado a acidosis láctica tipo B: Caso clínico Type B lactic acidosis associated with marginal lymphoma of the spleen: Report of one case

    Directory of Open Access Journals (Sweden)

    Jorge Vega

    2012-02-01

    Full Text Available Lactic acidosis in the absence of hypoxia or tissue hypoperfusion (type B is very rare and is associated with the use of some drugs or malignancy. We report a 79-year-old woman, with a marginal non-Hodgkin's lymphoma of the spleen that was subjected to a splenectomy one year ago. She presented with unexplained tachypnea associated with pancytopenia and elevation of IgM to 10 times over the higher normal limit. Laboratory tests showed the presence of metabolic acidosis and high lactic acid levels in the absence of infection, tissue hypoxia or hypoperfusion. She was treated with sodium bicarbonate and steroids without obtaining a reduction in lactate levels. Twelve days after admission, a single dose of Rituximab quickly normalized lactate concentrations and platelet count. After the fourth dose of Rituximab, pancytopenia disappeared and IgM fell to 25% of its baseline concentration.

  11. Rastreio virológico de carnívoros errantes e caracterização genética viral

    OpenAIRE

    Rosado, Ricardo Constante

    2009-01-01

    Dissertação de Mestrado Integrado em Medicina Veterinária ABSTRACT - Virological survey in stray carnivores and viral genetic characterisation - Free-roaming stray or feral dogs and cats living in urban areas can be responsible for the spread and maintenance of several infectious diseases. To investigate the presence of viral agents and the genomic diversity of canine and feline coronavirus (CCoV, FCoV) in Lisbon’s Municipal kennel, a virological survey was conducted which include...

  12. Ocorrência de protozoários e helmintos em amostras de fezes de cães errantes da Cidade de Itapema, Santa Catarina

    OpenAIRE

    Blazius Renê Darela; Emerick Sheila; Prophiro Josiane Somariva; Romão Pedro Roosevelt Torres; Silva Onilda Santos da

    2005-01-01

    Foram estudadas amostras fecais de cães apreendidos em logradouros públicos, pela vigilância sanitária de Itapema, SC. De 158 amostras examinadas, 121 (76,6%) foram positivas, com uma prevalência maior para Ancylostoma spp (70,9%), seguida por Toxocara canis (14,5%), Trichuris vulpis (13,9%), Isospora spp. (6,3%) e Dipylidium caninum (1,9%).

  13. Expression of the Lhx genes apterous and lim1 in an errant polychaete: implications for bilaterian appendage evolution, neural development, and muscle diversification

    Directory of Open Access Journals (Sweden)

    Winchell Christopher J

    2013-02-01

    Full Text Available Abstract Background Arthropod and vertebrate appendages appear to have evolved via parallel co-option of a plesiomorphic gene regulatory network. Our previous work implies that annelids evolved unrelated appendage-forming mechanisms; we therefore found no support for homology of parapodia and arthropodia at the level of the whole appendage. We expand on that study here by asking whether expression of the LIM homeobox (Lhx genes apterous and lim1 in the annelid Neanthes arenaceodentata supports homology of the dorsal branches as well as the proximodistal axes of parapodia and arthropodia. In addition, we explore whether the neural expression of apterous and lim1 in Neanthes supports the putative ancestral function of the Lhx gene family in regulating the differentiation and maintenance of neuronal subtypes. Results Both genes exhibit continuous expression in specific portions of the developing central nervous system, from hatching to at least the 13-chaetiger stage. For example, nerve cord expression occurs in segmentally iterated patterns consisting of diffuse sets of many lim1-positive cells and comparatively fewer, clustered pairs of apterous-positive cells. Additionally, continuous apterous expression is observed in presumed neurosecretory ganglia of the posterior brain, while lim1 is continuously expressed in stomatogastric ganglia of the anterior brain. apterous is also expressed in the jaw sacs, dorsal parapodial muscles, and a presumed pair of cephalic sensory organs, whereas lim1 is expressed in multiple pharyngeal ganglia, the segmental peripheral nervous system, neuropodial chaetal sac muscles, and parapodial ligules. Conclusions The early and persistent nervous system expression of apterous and lim1 in Neanthes juveniles supports conservation of Lhx function in bilaterian neural differentiation and maintenance. Our results also suggest that diversification of parapodial muscle precursors involves a complementary LIM code similar to those generating distinct neuronal identities in fly and mouse nerve cords. Expression of apterous and lim1 in discrete components of developing parapodia is intriguing but does not map to comparable expression of these genes in developing arthropod appendages. Thus, annelid and arthropod appendage development apparently evolved, in part, via distinct co-option of the neuronal regulatory architecture. These divergent patterns of apterous and lim1 activity seemingly reflect de novo origins of parapodia and arthropodia, although we discuss alternative hypotheses.

  14. Pseudoplaquetopenia em paciente submetida à esplenectomia de baço acessório: relato de caso Pseudoplaquetopenia en paciente sometida a la esplenectomía de bazo accesorio: relato de caso Pseudothrombocytopenia in a patient undergoing splenectomy of an accessory spleen: case report

    OpenAIRE

    Eduardo Jorge Yamada; Anne Francy Pereira Souto; Ellen da Encarnação Onety de Souza; Cid Amorim Nunes; Cremilda Pinheiro Dias

    2008-01-01

    JUSTIFICATIVA E OBJETIVOS: Os testes de coagulação (hemograma e tempo de protrombina) foram inicialmente concebidos como uma forma de rastrear e acompanhar coagulopatias congênitas raras e o hemograma é o que fornece o número de plaquetas por milímetro cúbico. O objetivo deste relato foi apresentar o caso de uma paciente que apresentava um número de plaquetas extremamente baixo quando sua amostra de sangue era analisada em tubo com EDTA e um número normal quando analisada com citrato, alertan...

  15. Osmanlı Ordusunda Venezuelalı Bir Gezgin Şövalye: Rafael de Nogales Méndez A Venezuelian Knight Errant In The Ottoman Army: Rafael de Nogales Méndez

    Directory of Open Access Journals (Sweden)

    Hüseyin Güngör ŞAHİN

    2013-09-01

    Full Text Available Rafael de Nogales Méndez, a citizen of Venezuela, served as asoldier of fortune in the World War I. Being a mysterious figure of hislifetime period, Nogales spent almost fifty years of his lifespan outside ofhomeland by going around the world away because of opposition to thedictatorial regimes. Nogales, passionate for military service andadventure, waged war in Cuba in 1898; he worked for dictator PorfirioDiaz as a mounted guard in the Mexican-American border; after a while,he had become a Mexican revolutionist by joining up the rebelliousforces against Diaz; a secret agent in the Far East, an assassin teammember in Guatemala; a rebel for years and a government officialduring the last period of his lifetime in his homeland. Nogales hadexpressed that his motto was; "When you see a good war, join up to it towaged war!" He was considering himself as "a soldier of fortune and thecitizen of the world". He was a military enthusiast, fighter, traveler,adventurer and also a writer. If I may say so, he was the Don Quixote ofthe 20th century.In this study, based on the memoirs quoted in the books ofNogales, his life history has been examined and the narratives of theauthor related the historical events in that period have been researchedcomparatively with the original sources. To this end, various officialsources, records and memoirs have been reviewed and made archivalresearch. On the other hand, earning new information and documentsto the literature in this field are among the objectives of the study. Venezuela vatandaşı Rafael de Nogales Méndez, I. Dünya Savaşı'nda Osmanlı Ordusu'nda gönüllü subay olarak görev yapmıştır. Yaşadığı dönemin gizemli figürlerinden biri olan Nogales, altmış yıllık ömrünün elli yılını muhalif olduğu dikta rejimleri nedeniyle ülkesinden uzakta, dünyayı dolaşarak geçirmiştir. Askerlik ve macera tutkunu Venezuelalı, 1898 yılında Küba'da savaşmış, Meksika-Amerika sınırında diktatör Porfirio Diaz'ın emrinde görevli bir atlı sınır muhafızıyken, yıllar sonra Diaz karşıtı isyancı kuvvetlere katılan bir devrimci, Uzakdoğu'da gizli ajan, Guatemala’da suikast timi üyesi, ülkesinde yıllarca bir asi, yaşamının son döneminde ise bir devlet görevlisi olmuştur. Şiarının "iyi bir savaş görürsen, savaşmak için ona gönüllü yazıl,"1 olduğunu belirten Nogales, bir asker, savaşçı, gezgin, maceraperest ve yazardı. Kendisini "bir dünya vatandaşı ve bir gezgin şövalye"2 olarak tanımlıyordu. Tabiri caizse, o, 20. yüzyılın Don Kişot'u idi.Bu çalışmada, Nogales'in anılarını aktardığı kitaplarında yer alan bilgilerden hareketle yaşam öyküsü irdelenirken, yazarın dönemin tarihi olaylarına dair anlatıları özgün kaynaklarla mukayeseli olarak incelenmiştir. Bu amaçla çok sayıda resmi kaynak ve hatırat gözden geçirilmiş, arşiv araştırması yapılmıştır. Öte yandan bu alanda literatüre yeni bilgi ve belge kazandırmak, çalışmanın amaçları arasında yer almaktadır.

  16. Estudo epidemiológico do vírus da imunodeficiência felina e do vírus da leucemia felina em gatos errantes e assilvestrados da ilha de São Miguel, Açores

    OpenAIRE

    Botelho, Sílvia Maria Almeida

    2014-01-01

    O vírus da Leucemia Felina (FeLV) e o vírus da Imunodeficiência Felina (FIV) pertencem à família Retroviridae. São responsáveis por duas viroses que ameaçam a vida e o bem-estar do gato doméstico, e a conservação de felinos silvestres como o lince da Península Ibérica. O principal objetivo deste estudo epidemiológico foi detetar a presença do FIV e do FeLV em gatos residentes na ilha de São Miguel, Açores. A amostra foi constituída por 90 gatos selecionados em grupos de risco elevado ou...

  17. Contribuição para o estudo da prevalência da infecção por Leishmania infantum em gatos domésticos e errantes nos distritos de Lisboa e Viseu

    OpenAIRE

    Garrido, Joana Margarida da Cruz Baptista Galvão

    2012-01-01

    A Leishmaniose visceral zoonótica causada por Leishmania infantum é considerada uma doença endémica no nosso País. Sabe-se que o cão é o principal hospedeiro reservatório, no entanto, o papel do gato (Felis catus) na epidemiologia da doença têm vindo adquirir um interesse crescente. A presente dissertação baseia-se em um rastreio epidemiológico da infecção por Leishmania infantum em gatos dos distritos de Lisboa e Viseu. A amostra total foi de 80 gatos correspondendo 40 animais a cada área ge...

  18. SPLETNA APLIKACIJA ZA IZDELAVO LETALSKIH TOVORNIH LISTOV

    OpenAIRE

    Toman, Jaka

    2010-01-01

    V nalogi je prikazana spletna aplikacija, ki podpira celoten proces izdelave letalskih tovornih listov. Aplikacija tako omogoča izpolnjevanje in tiskanje tovornih listov, generiranje številk letalskih tovornih listov, dodajanje strank v bazo podatkov, izdelavo in tiskanje poročil. Spletna aplikacija je izdelana s pomočjo Microsoftovih orodij Visual Studio 2005, pri katerem smo uporabili programski jezik Visual Basic.NET in izvajalno okolje ASP.NET. Bazo podatkov smo izdelali v programu Micros...

  19. Detecção de Ehrlichia spp./Anaplasma spp., Rickettsia spp., Mycoplasma haemofelis e Leishmania infantum em felinos errantes e sua relação com a presença de retrovírus e com a sintomatologia manifestada

    OpenAIRE

    Martins, Telma Simone Oliveira

    2012-01-01

    ABSTRACT - Detection of Ehrlichia spp./Anaplasma spp., Rickettsia spp., Mycoplasma haemofelis and Leishmania infantum in stray cats, and its relation to the presence of retroviruses and the symptoms manifested - The prevalence of infectious diseases on cats is related with the density and the size of the population indwells. The objective of this work was to determinate the prevalence of the feline immunodeficiency virus (FIV), feline leukemia virus (FeLV), Ehrlichia spp./Anaplasma s...

  20. Anti-Brucella abortus antibodies in free-ranging equids from Mossoró, Rio Grande do Norte, BrazilAnticorpos anti-Brucella abortus em equídeos errantes do município de Mossoró, Rio Grande do Norte

    Directory of Open Access Journals (Sweden)

    Elaine Maria Seles Dorneles

    2013-06-01

    Full Text Available The aims of the present study were (i to determine the occurrence and (ii to evaluate possible factors associated with infection by Brucella abortus in free-ranging equids from Mossoró, Rio Grande do Norte, Brazil. Sera from 227 free-ranging equids (178 donkeys, 43 horses and 6 mules, captured by the highway police and the prefecture agents, were screened by the rose bengal test (RBT and confirmed for B. abortus-antibodies by the standard tube agglutination (STAT and the 2-mercaptoethanol (2ME tests. Of the 227 equids tested, four (1.76% were positive for B. abortus antibodies. All were horses, which resulted in an observed frequency of infection for this species of 9.30% (4/43. No association was found among seropositivity for B. abortus and the age and sex. Thus, data from the present study showed that infection by B. abortus is present among horses in Mossoró, Rio Grande do Norte, Brazil. Os objetivos deste trabalho foram (i determinar a ocorrência da infecção por Brucella abortus em equídeos de vida livre no município de Mossoró, Rio Grande do Norte e (ii avaliar possíveis fatores associados a esta infecção. Soros de 227 equídeos (178 asininos, 43 equinos e 6 muares, capturados pela polícia rodoviária e funcionários da prefeitura, foram coletados por punção venosa. A pesquisa de anticorpos anti-Brucella abortus foi realizada empregando-se, como triagem, o teste do antígeno acidificado tamponado (AAT e como confirmatório o teste de redução pelo 2-Mercaptoetanol (2ME. Dos animais testados, quatro (1,76% foram positivos para anticorpos anti- B. abortus. Todos os positivos eram equinos (9,30%, 4/43. A análise das variáveis levantadas (sexo e idade como possíveis fatores associados à infecção por B. abortus não revelou a existência de associação entre estas e a soropositividade. Assim, o presente estudo permite concluir que a infecção por B. abortus está presente em equinos do município de Mossoró, Rio Grande do Norte.

  1. The Demonstration of "Big Fantasy" with Civilization Built on Alternate History:-Takjng the Singularly Varied and Knight-errant Literature of Yan Leisheng as the Example%文明架空历史的"大幻想"展示: 以燕垒生奇幻武侠文学为例

    Institute of Scientific and Technical Information of China (English)

    韩云波

    2009-01-01

    在当下文明架空历史背景的奇幻武侠文学中,燕垒生是一个典型的例子,他通过时空压缩表现了从蛮荒经历帝制最后到共和的文明进程,同时也通过地缘的拓展表现了全球化时代的伦理超越,他还思考了在观赏性基础上对"写文化"和"写人性"二者的价值体验,这些都对当下奇幻武侠文学创作的发展提供了有益的启示.

  2. Ocorrência de protozoários e helmintos em amostras de fezes de cães errantes da Cidade de Itapema, Santa Catarina Occurrence of protozoa and helminthes in faecal samples of stray dogs from Itapema City, Santa Catarina

    OpenAIRE

    Renê Darela Blazius; Sheila Emerick; Josiane Somariva Prophiro; Pedro Roosevelt Torres Romão; Onilda Santos da Silva

    2005-01-01

    Foram estudadas amostras fecais de cães apreendidos em logradouros públicos, pela vigilância sanitária de Itapema, SC. De 158 amostras examinadas, 121 (76,6%) foram positivas, com uma prevalência maior para Ancylostoma spp (70,9%), seguida por Toxocara canis (14,5%), Trichuris vulpis (13,9%), Isospora spp. (6,3%) e Dipylidium caninum (1,9%).Samples of feces from dogs seized by the health surveillance program of Itapema city, SC, were studied. From 158 samples examined 121 (76.6%) were positiv...

  3. Ocorrência de protozoários e helmintos em amostras de fezes de cães errantes da Cidade de Itapema, Santa Catarina Occurrence of protozoa and helminthes in faecal samples of stray dogs from Itapema City, Santa Catarina

    Directory of Open Access Journals (Sweden)

    Renê Darela Blazius

    2005-02-01

    Full Text Available Foram estudadas amostras fecais de cães apreendidos em logradouros públicos, pela vigilância sanitária de Itapema, SC. De 158 amostras examinadas, 121 (76,6% foram positivas, com uma prevalência maior para Ancylostoma spp (70,9%, seguida por Toxocara canis (14,5%, Trichuris vulpis (13,9%, Isospora spp. (6,3% e Dipylidium caninum (1,9%.Samples of feces from dogs seized by the health surveillance program of Itapema city, SC, were studied. From 158 samples examined 121 (76.6% were positive, with a prevalence of Ancylostoma spp (70.9%, followed by Toxocara canis (14.5%, Trichuris vulpis (13.9%, Isospora spp (6.3% and Dipylidium caninum (1.9%.

  4. Automated Flight Safety Inference Engine (AFSIE) System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop an innovative Autonomous Flight Safety Inference Engine (AFSIE) system to autonomously and reliably terminate the flight of an errant launch...

  5. Anemia esplénica hemolítica de origen palúdico: consideraciones sobre esplenomegalia e indicaciones de la esplenectomía

    OpenAIRE

    Sarmiento, Pedro Jose

    2012-01-01

    Falta demostrar de una manera científica cuales son las causas que han producido las alteraciones de la función normal hemolítica del bazo. Hay algunos factores que permiten pensar en la hipótesis que tiene bastantes probabilidades en su favor de que sean las toxinas de los hematozoarios de Laveran las responsables. Así, se encuentra en todos estos enfermos las reinfecciones palúdicas, en su pasado patológico; se sabe que el órgano más afectado en esta enfermedad es el bazo, se sabe que exist...

  6. Spleen and Lymphatic System

    Science.gov (United States)

    ... Help a Friend Who Cuts? Spleen and Lymphatic System KidsHealth > For Teens > Spleen and Lymphatic System Print A A A Text Size What's in ... en español Bazo y sistema linfático The lymphatic system is an extensive drainage network that helps keep ...

  7. Nódulo solitario esplénico en paciente con leucemia mieloblástica aguda

    OpenAIRE

    Eva García Alberdi; Fidel Fernández Fernández

    2012-01-01

    Historia clínica: Varón de 65 años, diagnosticado de leucemia mieloblástica aguda en tratamiento con quimioterapia. En el bazo se observa un nódulo único, bien circunscrito, de unos dos centímetros de diámetro

  8. Prevalência de vírus da imunodeficiência felina, vírus da leucemia felina, calicivírus felino, herpesvírus felino tipo 1 e candida spp. em felinos errantes e possível associação a gengivo-estomatite crónica felina e a doença respiratória felina

    OpenAIRE

    Rodrigues, Cláudia Vanessa de Barros

    2012-01-01

    ABSTRACT - Detection of Feline Immunodeficiency Virus, Feline Leukemia Virus, Feline Calicivirus, Feline Herpesvirus-1 and Candida spp. in stray cats and possible association with Feline Gingivostomatitis and Feline Respiratory Disease - The aim of this study was to analyze the viral and mycological microbiota of cats’ mouth and its relationship with the clinical symptoms, especially with Feline Gingivo-Stomatitis (FGS) and Feline Respiratory Disease (FRD), and infection with Feline ...

  9. Estudo de validação comparativo entre as técnicas Elisa e RIFI para diagnosticar Leishmania sp em cães errantes apreendidos no município de Campos dos Goytacazes, Estado do Rio de Janeiro Comparative validation study between the ELISA and RIFI techniques for diagnosing Leishmania sp in stray dogs caught in the municipality of Campos de Goytacazes, State of Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Mariane Pinto Fernandes Távora

    2007-08-01

    Full Text Available Foi realizada uma pesquisa objetivando-se verificar a eficácia do teste ELISA, para detecção de anticorpos contra Leishmania sp em cães, comparando-o com o RIFI, padrão em humanos, e investigar a situação sorológica desta zoonose na microrregião. Os testes tiveram uma concordância de 97,6%, classificada como forte.A survey was carried out aiming to verify the ELISA test effectiveness for detecting antibodies against Leishmania sp in dogs, comparing with RIFI human pattern and for investigating sorological zoonosis situation in the microregion. An accordance about 97.6% considered strong was reported.

  10. Knight-Errantry. Code Word and Punch Line in Edmund Gayton's "Festivous Notes on Don Quixote" (1654 and 1768

    Directory of Open Access Journals (Sweden)

    Clark Colahan

    2013-12-01

    Full Text Available Gayton viewed Cervantes's famous protagonist as the representative of an outdated and anomalous code of conduct, as well as a hypocrite who fails to live up to the high standards demanded by that code. Gayton ridicules the protagonist's profession by employing the English expressions knight-errant and knight errantry, which the first translation of the novel uses to render caballero andante and caballería andante. He thus played on the secondary meaning of errant as mistaken, as well as on the implied homonym arrant, an intensifying adverb carrying highly negative connotations (an arrant coward. Gayton then coined related satirical neologisms for groups such as that of the ladies-errant, thereby suggesting their reprehensible behaviour.

  11. SPLETNI INFORMACIJSKI SISTEM ZA ZOBOZDRAVSTVENE ORDINACIJE

    OpenAIRE

    Fajertag, Denis

    2010-01-01

    V diplomski nalogi smo predstavili zahteve za vodenje in delovanje zobozdravstvenih ordinacij. Pri izdelavi diplomske naloge smo uporabili označevalni jezik XHTML v povezavi s stilskimi predlogami CSS, programski jezik PHP, skriptni jezik JavaScript, knjižnico jQuery, tehnologijo AJAX in podatkovno bazo MySQL. Vse te tehnologije smo tudi predstavili in ponazorili s konkretnimi primeri. Po predstavitvi uporabljenih tehnologij smo predstavili še avtorizacijo uporabnikov v spletnem sistemu ter v...

  12. SPLETNA REŠITEV DOKUMENTIRANJA ZDRAVSTVENE NEGE

    OpenAIRE

    Roblek, Anže

    2014-01-01

    V magistrski nalogi je predstavljen razvoj spletne rešitve dokumentiranja zdravstvene nege, ki je bila razvita za Zdravstveno fakulteto Univerze v Ljubljani. Naloga opisuje izdelavo spletne rešitve, izdelane v jezikih HTML, PHP in JavaScript, ki za svoje delovanje uporablja bazo podatkov MySQL. Rešitev je bila izdelana z namenom prenove procesa izpolnjevanja dokumentacije zdravstvene nege s pomočjo informacijske podpore. V primerjavi s starim, informacijsko nepodprtim procesom, prenovljen pro...

  13. Archimate kot modelirni jezik za razvoj mobilne aplikacije

    OpenAIRE

    Fajfar, Bojan

    2016-01-01

    V diplomskem delu smo predstavili standard in modelirni jezik Archimate ter njegovo praktično uporabo. V prvem delu smo predstavili osnove jezika, njegove značilnosti, strukturo in različne poglede, v drugem pa poslovno informacijsko tehnologijo za mobilno banko. Analizirali in predstavili smo programsko opremo kot storitev ter praktično uporabo jezika Archimate in njegovih vidikov. Predstavili smo podatkovno bazo in entitetni podatkovni model v Martinovi notaciji za aplikacijo mobilne banke ...

  14. Razvoj spletne aplikacije s pomočjo Codelgniter

    OpenAIRE

    Gerdej, Nejc

    2015-01-01

    V prvem delu diplomske naloge bom predstavil spletni programski jezik PHP, delo s podatkovno bazo MySql, ogrodje CodeIgniter in arhitekturni vzorec MVC programiranja. Teoretične razlage primerov bodo služile kot osnova za nadaljnje razumevanje tehnične zasnove razvoja lastne spletne aplikacije, ki jo bom predstavil v drugem delu diplomske naloge. Opisal bom pomembnejše dele spletne aplikacije za preprosto vodenje delovnih opravil – zahtevkov. Aplikacija sledi arhitekturnemu vzorcu MVC.

  15. L'astronomie dans le monde

    Science.gov (United States)

    Manfroid, J.

    2010-01-01

    Galaxie cannibale; Archéologie cosmique; Trumpler 14; Etoile vampire; Trou noir errant; Micro-quasar gamma; Métaux intergalactiques; V838 Mon; Supernova particulière; Titan; Mars; Vie martienne; Variations des étoiles semblables au Soleil; GJ758B

  16. Students' Mental Model Development during Historically Contextualized Inquiry: How the "Tectonic Plate" Metaphor Impeded the Process

    Science.gov (United States)

    Dolphin, Glenn; Benoit, Wendy

    2016-01-01

    At present, quality earth science education in grade school is rare, increasing the importance of post-secondary courses. Observations of post-secondary geoscience indicate students often maintain errant ideas about the earth, even after direct instruction. This qualitative case study documents model-building activities of students as they…

  17. Compelling Untruths: Content Borrowing and Vivid False Memories

    Science.gov (United States)

    Lampinen, James Michael; Meier, Christopher R.; Arnal, Jack D.; Leding, Juliana K.

    2005-01-01

    False memories are sometimes accompanied by surprisingly vivid experiential detail that makes them difficult to distinguish from actual memories. Such strikingly real false memories may be produced by a process called content borrowing in which details from presented items are errantly borrowed to corroborate the occurrence of the false memory…

  18. Poor Auditory Task Scores in Children with Specific Reading and Language Difficulties: Some Poor Scores Are More Equal than Others

    Science.gov (United States)

    McArthur, Genevieve M.; Hogben, John H.

    2012-01-01

    Children with specific reading disability (SRD) or specific language impairment (SLI), who scored poorly on an auditory discrimination task, did up to 140 runs on the failed task. Forty-one percent of the children produced widely fluctuating scores that did not improve across runs (untrainable errant performance), 23% produced widely fluctuating…

  19. Les mémoires de la dynastie Tang

    Science.gov (United States)

    Bonnet-Bidaud, J. M.

    1996-07-01

    Dans la nuit des temps, les astronomes chinois ont ete d'incomparables observateurs de cometes. Ces savants, dont les notations raffinees ponctuaient l'histoire officielle des empereurs, relevaient chaque passage d'astre errant avec une precision inestimable. Un veritable tresor ou puise encore la science contemporaine.

  20. Factores psicológicos y salud asociados con un nuevo perfil de jubilados

    OpenAIRE

    Izarne Lizaso; Manuel Sánchez de Miguel; Luixa Reizábal

    2008-01-01

    Conforme a los cambios sociales y económicos, la tipología y definición del jubilado va siendo modificada en las últimas décadas. Hoy por hoy no existe un amplio consenso para definir a la persona jubilada como hasta ahora tradicionalmente se había hecho. Así, en diferentes estudios aparecen nuevos términos: nuevo perfil de jubilados (Canes y García, 1989), nueva vejez (Bazo, 1992; 1996; 2000) y nuevos jubilados (De Zayas, 1996). El objetivo principal de esta investigación ha sido analizar el...

  1. Trauma esplénico

    OpenAIRE

    Cortés Díaz, Fabio F.; Buitrago Mejía, Francisco; Ulloa Guerrero, Luis Heber

    2010-01-01

    El bazo es el órgano que con mayor frecuencia se lesiona durante el trauma cerrado y es la causa más común de muerte previsible en los pacientes con heridas abdominales. En la actualidad las complicaciones del trauma esplénico se relacionan con su severidad, presencia de heridas asociadas, fallas diagnósticas o tratamientos inadecuados. Las lesiones que se diagnostican en forma temprana son manejadas rápida y satisfactoriamente, pero las heridas olvidadas o los diagnósticos y tratamientos tar...

  2. RAZVOJ SPLETNIH APLIKACIJ NA OSNOVI OGRODIJ ANGULARJS IN EXPRESS

    OpenAIRE

    Rebernak, Rok

    2016-01-01

    Poznavanje sodobnih tehnologij je ključnega pomena za hiter in učinkovit razvoj modernih spletnih aplikacij, zato smo v diplomskem delu preučili nekatere perspektivne odprtokodne JavaScript rešitve. Podrobno smo preučili ogrodje AngularJS, ki se izvaja na strani odjemalca, in ogrodje Express, ki je najbolj priljubljeno ogrodje za strežniško platformo Node.js. Prav tako smo preučili objektno orientirano podatkovno bazo MongoDB in paket za modeliranje v Node.js - Mongoose. Znanje, ki smo ga pri...

  3. Glucogenosis tipo I: reporte de dos casos en dos hermanos de Cartagena de Indias-Colombia

    OpenAIRE

    Alvear-Sedán Ciro; Barboza-Ubarnes, Miryam; Bonillas-Fierro Miguel [q.e.p.d

    2011-01-01

    CASO CLÍNICO: # 1. Producto del primer embarazo de padres no consanguíneos, con lactancia hasta los dos años. A los 18 meses deedad presentó distensión abdominal, hepatomegalia difusa no dolorosa, diarrea de mes y medio, debilidad generalizada, edemaprogresivo en cara y pies, anasarca y anemia. Vesícula, bazo y riñones normales y examen neurológico sin alteraciones. Nopresentó hipoglucemia, ácido láctico normal. Pruebas hepáticas alteradas; colesterol, triglicéridos y ácido úrico en el límite...

  4. Sinusoid-lining cells are novel myeloid-endothelial innate cells that form splenic niches for marginal zone B cell activation and plasma cell survival

    OpenAIRE

    Barra Quaglia, Carolina M., 1982-

    2014-01-01

    Los sinusoides del bazo humano promueven la lenta percolaci??n de lasangre, favoreciendo la captura de ant??geno por los fagocitos ylinfocitos del sistema inmune local. Estrat??gicamente posicionadasdelimitando los vasos, e hist??ricamente conocidas como c??lulasret??culo-endoteliales, las c??lulas que delinean los sinusoides (SLCs),tienen una biolog??a enigm??tica y podr??an ser vistas como uncomponente desconocido del sistema inmunol??gico. En esta tesishemos observado que las SLCs pose??an...

  5. PRESOJA VAROVANJA PODATKOV IN INFORMACIJ V RAČUNOVODSKEM SERVISU

    OpenAIRE

    Podjaveršek, Nataša

    2011-01-01

    Večja varnost podatkov in informacij v računovodskem servisu zmanjša tveganje poslovanja, poveča zaupanje strank v računovodski servis in njihovo delo, zmanjša tveganje pred vdorom v bazo podatkov, zmanjša tveganje pred razkritjem podatkov. Za zagotavljanje varnosti podjetja je potrebno upoštevati veljavno zakonodajo, predvsem Zakon o varovanju osebnih podatkov, Zakon o elektronskem poslovanju in druge zakonske predpise. Informacijska varnost v računovodskem servisu pomeni varstvo podatk...

  6. Računalniški vid za pametno knjižnico

    OpenAIRE

    Trček, Matej

    2016-01-01

    S prostoročnimi vmesniki lahko tehnologijo na udoben način vključimo v vsakdanje dejavnosti. Diplomsko delo opisuje izdelavo aplikacije za prepoznavanje knjižnih platnic z barvno-globinsko kamero za rabo v pametni knjižnici. Aplikacija v globinski sliki zazna ravnino, v njej najde štirikotnik in ga naravna v ravnino kamere. V naslednjem koraku s tehnikami računalniškega vida primerja najdeno sliko s pripravljeno podatkovno bazo posnetkov knjižnih platnic in najde najboljše ujemanje. Globinska...

  7. SPLETNA REŠITEV ZA NADZOR PROIZVODNJE

    OpenAIRE

    Šubelj, Matevž

    2013-01-01

    V magistrski nalogi smo razvili spletno rešitev za dostop do podatkov proizvodnih prostorov podjetja. Rešitev je napisana v programskem jeziku VB.NET ter je osnovana na ASP.NET in .NET ogrodju. Kot bazo je uporabljen MSSQL. Del podatkov je črpan tudi iz baze MySQL. Uporabljen je tudi industrijski krmilnik Cybro. Rešitev prikazuje trenutno stanje obratovanja strojev, zgodovino za nazaj, vlago, temperaturo, točko rosišča in ima vmesnik za vnos prašnih delcev. Spletni del rešitve teče na strežni...

  8. Papel de las células mesenquimales expandidas in vitro para mejorar el injerto en el contexto del trasplante hematopoyético

    OpenAIRE

    Carrancio Antón, Soraya

    2010-01-01

    [ES] El trasplante de progenitores hematopoyéticos (TPH) es un procedimiento terapéutico destinado a reconstituir el tejido hematopoyético del paciente, que generalmente presenta una insuficiencia medular o sufre una enfermedad neoplásica. Ya a finales del S.XIX, Brown-Sequard planteó la posibilidad de reconstituir la producción de células sanguíneas en casos de anemia con la administración de bazo de animales, crudo o cocido. Pero no fue hasta los años 50 cuando se consiguió r...

  9. SPLETNA APLIKACIJA ZA SPREMLJANJE PODATKOV O FILMIH

    OpenAIRE

    Cedula, Simon

    2013-01-01

    V diplomskem delu opisujemo izbiro ogrodja za izdelavo spletne aplikacije, načine pridobivanja podatkov, izgled in funkcionalnost aplikacije ter načine optimizacije. Rezultat diplomskega dela je spletna aplikacija, ki je napisana v programskem jeziku PHP s pomočjo tehnologij HTML, JavaScript, CSS in SVG. Aplikacija omogoča spremljanje uporabnikovih podatkov o serijah in filmih ter dodajanje novih vnosov v podatkovno bazo naslovov. Kot dopolnilo spletne aplikacije je bila izdelana še namizna a...

  10. SPLETNA STRAN ZA IZMENJAVO ŠTUDIJSKIH GRADIV

    OpenAIRE

    Bitenc, Marko

    2014-01-01

    Diplomska naloga predstavlja izgradnjo dinamične spletne strani, ki bo delovala na osnovi programskega jezika PHP. Spletna stran je namenjena izmenjavi študijskih gradiv med študenti Fakultete za organizacijske vede v Kranju in omogoča bodočim študentom pomoč pri študiju. Spletna stran omogoča prikaz vsebine glede na izbiro uporabnika. V ta namen smo uporabili bazo podatkov, ki nam omogoča izpis izbranih podatkov. Uporabnik lahko vanjo tudi sam dodaja predmete in zapiske. Uvodni del n...

  11. LOKALIZACIJA PAKETA ORANGE HRM

    OpenAIRE

    Berčič, Sergej

    2014-01-01

    Diplomsko delo obravnava izdelavo slovenskega jezikovnega paketa za odprtokodno programsko rešitev za upravljanje s človeškimi viri OrangeHRM. Kratko je opisano odprtokodno razvojno okolje, ki ga vključuje paket XAMPP: spletni strežnik Apache, sistem za upravljanje z bazo podatkov MySQL, PHP in Perl. Za prevajanje je bil uporabljen urejevalnik Notepad++. Prikazan je postopek namestitve paketa OrangeHRM, nato pa so opisane funkcije posameznih modulov: administrator, osebni podatki, odsotnosti,...

  12. SPLETNA REŠITEV ZA EVIDENTIRANJE DARIL IN NAGRAD

    OpenAIRE

    Batistič, Matej

    2011-01-01

    Diplomsko delo prikazuje aplikacijo za centralno zbiranje podatkov o dodeljenih nagradah komitentom banke z namenom pravočasne zagotovitve podatkov za poročanje DURS. Na začetku diplome je predstavljeno problemsko stanje v podjetju in opis metode, na osnovi katere je bila spletna aplikacija razvita. Aplikacijo smo razvili s pomočjo programskega jezika C# in razvojnega orodja Visual Studio 2005 v .Net okolju v kombinaciji z Oracle 10g podatkovno bazo podatkov. V osrednjem delu je opisan proces...

  13. RAZVOJ MOBILNE SPLETNE APLIKACIJE ZA GOSTINSTVO

    OpenAIRE

    Močnik, Tomaž

    2012-01-01

    V diplomski nalogi bomo obravnavali področje razvoja mobilnih spletnih aplikacij, natančneje razvoj mobilne spletne aplikacije za pomoč v gostinstvu. Spoznali se bomo z rešitvami, katere so trenutno prosto dostopne ter jih uporabili v procesu izdelave. Podrobneje si bomo ogledali HTML5, jQuery Mobile, strežniški skriptni jezik PHP ter MySQL podatkovno bazo. Aplikacija bo tako omogočala hitrejše naročanje, napreden pregled nad prometom ter vodenje podjetja od doma in tako povečanje efektivnost...

  14. Linfomatosis Bovina. Morfopatología en dos casos de campo

    OpenAIRE

    Joa, R.; Ancizar, J.; Betancourt, A.; Babaahmadi,

    2005-01-01

    La Linfomatosis ocurre exclusivamente en el tejido linfoide, de tal forma, que no está restringida en su origen a los ganglios linfáticos y el bazo, sino que surge también en los nódulos linfoides. En su diseminación puede afectar no solo al tejido linforreticular, sino a cualquier otro también (Ferrer, 1980). Se describe el cuadro lesional observado en dos hembras bovinas adultas, con edades de cinco y siete años, pertenecientes a una Unidad de Producción Lechera, las cuales fueron enviadas ...

  15. Efectos de la contaminación atmosférica en poblaciones de pequeños roedores silvestres ("Microtus mexicanus", "Peromyscus melanotis" y "Peromyscus difficilis") en México, D. F.

    OpenAIRE

    Gómez Ugalde, Rosa María

    2003-01-01

    [spa] El objetivo del presente trabajo es evaluar la influencia de la contaminación atmosférica de la Zona Metropolitana de la Ciudad de México sobre las poblaciones de Microtus mexicanus, Peromyscus melanosis y P. difficilis en los Parques Nacionales: Desiertode los Leones (Desierto) y el Ajusco (Ajusco) para lo cual se analizó la estructura y ultraestructura del epitelio traqueal; el análisis histopatológico de: pulmón, hígado, bazo y riñón y la acumulación de metales (As, Al, Cd, Cr, Cu, M...

  16. Vestigio clínico inusual asociado a abdomen agudo traumático

    OpenAIRE

    Carlos Baeza-Herrera; José Luis Atzin-Fuentes; Mirna Edith Ramírez-Meneses; Tomás González-Mateos; Javier López-Castellanos

    2008-01-01

    Introducción: El uso de la bicicleta es muy popular en niños; 80 a 90 % de los infantes en edad escolar tiene su propia bicicleta. Desafortunadamente, los percances debido al empleo de estos vehículos resulta en aproximadamente 600 decesos cada año en países como Estados Unidos. Adicionalmente, el impacto directo sobre los manubrios lesiona frecuentemente hígado, bazo, páncreas, riñones, intestino, uretra y grandes vasos. El objetivo de esta comunicación es describir el mecanismo mediante el ...

  17. Understanding, Assessing, and Resolving Light-Pollution Problems on Sea Turtle Nesting Beaches

    OpenAIRE

    Witherington, Blair E.; Martin, R. Erik

    2000-01-01

    Making the public aware of light-pollution problems on sea turtle nesting beaches is a fundamental step towards darkening beaches for sea turtles. Many of those responsible for errant lighting are unaware of its detrimental effects and are generally willing to correct the problem voluntarily once they become aware. Nonetheless, legislation requiring light management is often needed, and on many nesting beaches, it may be the only means to completely resolve light-pollu...

  18. Challenging the paradigms of gut architecture and feeding biomechanics in shallow water polychaetes

    OpenAIRE

    Dinley, J

    2012-01-01

    For well over a century a great deal of effort has been expended into investigation of how polychaetes capture their food but there has been a relative lack of attention paid to the processing of ingested material in the various forms and functioning of the anterior gut in errant polychaetes. The principal focus of this study was the examination of the functional anatomy of the anterior digestive tracts from three families of polychaetes; the Arenicolidae; sedentary detritivores, the Nereidae...

  19. "A Financial Crisis Manual Causes, Consequences, and Lessons of the Financial Crisis"

    OpenAIRE

    Ben Beachy

    2012-01-01

    On the fifth anniversary of the beginning of the Great Recession, there is still no consensus on the lessons to be gleaned from the lingering crisis. What provoked the largest financial and economic collapse in decades? While the housing bubble and subprime mortgage lending boom provide clear proximate causes, skewed financial sector incentives, errant economic assumptions, and inequitable socioeconomic structures laid the groundwork for crisis. The complex web of underlying factors extends f...

  20. Il viaggio gastronomico di Paolo Monelli

    Directory of Open Access Journals (Sweden)

    Alberto Salarelli

    2013-01-01

    Full Text Available Il ghiottone errante di Paolo Monelli, pubblicato nel 1935, rappresenta uno dei primi esempi di narrativa di viaggio in tema di enogastronomia, un genere destinato a grande successo nel secondo dopoguerra. In questo articolo, oltre a ripercorrere la vicenda biografica di Monelli, si sottolineano le relazioni tra Il ghiottone e la cultura gastronomica del regime fascista, e si evidenziano alcuni tratti caratteristici del suo stile di scrittura.

  1. DESARROLLO DE UN PROGRAMA MODELO DE TALLER CREATIVO, ENFOCADO EN EL AUTOCONOCIMIENTO, AUTORREGULACIÓN Y AUTOCOMPASIÓN DE JÓVENES UNIVERSITARIOS A TRAVÉS DEL ARTE.

    OpenAIRE

    GODOY ACOSTA, DIANA CAROLINA

    2016-01-01

    [EN] Understanding the education from an integral perspective is not an easy issue. Several institutions focus their efforts in the achievement on the top places on the national and international rankings, becoming in experts generators of well-known errant brains. But they do not intuit that education is precisely something more than the simple transmission of knowledge to a person so that it acquires a determined training. In several academic scenarios they forget that education implies the...

  2. An irresponsible biography of the actor Laurence Harvey: motion pictures, white wine, older women & long thin cigarettes

    OpenAIRE

    Brannon, Matthew

    2015-01-01

    Tiré du site Internet de Onestar Press: "Pocket edition of Laurence Harvey's "irresponsible" biography by Matthew Brannon. From the back cover of the book : Call yourself an actor ? You're not even a bad actor. You can't act at all, you fucking stupid hopeless sniveling little cunt-faced cunty fucking shit-faced arse-hole ... LAURENCE OLIVIER to Laurence Havery from Robert Stephen's "Knight errant : memoirs of a vagabond actor", Hodder and Stoughton, 1995.".

  3. The clown at the gates of the camp : sovereignty, resistance and the figure of the fool.

    OpenAIRE

    Amoore, L.; Hall, A

    2013-01-01

    This article considers the figure of the clown-fool as a way of approaching anew contemporary practices of sovereignty and resistance. The spectre of the camp as the nomos of modern sovereign power is widely critiqued for its neglect of the thriving and teeming life that actually accompanies the declaration of exception. The clown is an errant and troublesome figure whose life haunts the sovereign decision on exception. His presence in border-camp activism invokes a rich, provocative history ...

  4. L'astronomie dans le monde

    OpenAIRE

    Manfroid, Jean

    2006-01-01

    Pôle errant; Pluton et Charon; Du côté d'Uranus !; Stardust; G29-38; La chasse aux planètes; Etoile polaire; Véga; Vers un interféromètre infrarouge à base kilométrique; Des pulsars extraordinaires; Trous noirs intermédiaires; Le trou noir central de la Galaxie; N44; Tornade spatiale

  5. Efecto de la Esplenectomia en la infección a Babesias de la ardilla Citellus Tridecemlineatus

    Directory of Open Access Journals (Sweden)

    Arístides Herrer

    1956-07-01

    Full Text Available Observaciones en el Citellus tridecemilineatus con infecciones latentes a babesias ponen de manifiesto que la esplenectomía desencadena una inusitada intensificación del parasitismo, marcada anemia y otras alteraciones que pueden conducir a la muerte del animal. De cifras inferiores a 1 por mil que usualmente se observa en las infecciones latentes, con la esplenectomía la parasitemia se intensifica en tal forma que en ciertas ocasiones suele comprender a algo más del 80 por ciento de los eritrocitos. De igual manera aumenta notablemente la intensidad con que son parasitados los hematies, verificándose después de la extirpación del bazo eritrocitos con 8, 10 y 12 parásitos. Los resultados de estos estudios señalan la enorme importancia que el bazo tendría en la defensa contra la infección latente de esta especie de babesia, de manera parecida a lo que sucede principalmente en las infecciones a bartonellas de ciertos animales.

  6. Efecto inmunomodulador de la solución CM-95 tratada magnéticamente en ratones Balb/c inoculados con 5-fluorouracilo

    Directory of Open Access Journals (Sweden)

    Clara Martínez

    2011-04-01

    Full Text Available El 5-fluorouracilo es un antineoplásico usado en la terapia del cáncer y posee acción inmunosupresora al inhibir la proliferación de células del tejido hematopoyético. En este trabajo se evaluó el efecto inmunomodulador de la solución CM-95 tratada magnéticamente en ratones Balb/c inoculados con 5-fluorouracilo a través de su acción protectora rehabilitadora sobre parámetros celulares y tisulares del tejido hematopoyético. A los ratones, entre 20-22 g de peso y 6 semanas de nacidos, se les administró esta solución CM-95 tratada magnéticamente por vía intraperitoneal en un esquema de dos inoculaciones; luego se administró por la misma vía el 5_fluorouracilo a una dosis de 150 mg/m2 de superficie corporal de cada ratón. Se evaluó el conteo total y diferencial de leucocitos antes de inocular el 5-fluorouracilo, y a los tres y siete días de aplicado este. La celularidad de médula ósea y bazo y la observación microscópica del corte histológico de hígado y bazo por la técnica de inclusión en parafina y tinción con eosina hematoxilina al 10% se evaluaron a los siete días de haber aplicado el 5- fluorouracilo. La solución CM-95, tratada magnéticamente, logró modular los efectos del 5-fluorouracilo con una actividad protectora rehabiltadora, para los parámetros evaluados en médula ósea, sangre periférica, bazo e hígado. Estos resultados abren nuevas perspectivas para la aplicación del sistema acuoso tratado magnéticamente como inmunomodulador.

  7. Propriedades biomecânicas da fáscia lata e do ligamento cruzado cranial de cães Biomechanical properties of canine fascia lata and cranial cruciate ligament

    Directory of Open Access Journals (Sweden)

    A.P. Brendolan

    2001-02-01

    Full Text Available Preparações bilaterais do ligamento cruzado cranial e da fáscia lata de 15 cães foram testadas na máquina Instron, modelo 4482. Os animais, de ambos os sexos, idade entre um e quatro anos, pesavam em média 11,80 ± 1,99kg. Os retalhos de fáscia lata foram testados retilíneos e torcidos e o ligamento cruzado cranial foi testado mantendo um ângulo de 135° entre a tíbia e o fêmur e 0°, 15° de rotação externa e 15° de rotação interna da tíbia em relação ao fêmur. A velocidade dos testes de tração foi de 8,47mm por segundo. A força máxima dos retalhos de fáscia lata foi aproximadamente de 290 Newtons, e a tensão máxima, 28 Megapascal. A torção não influenciou na resistência dos retalhos de fáscia lata. A rotação externa e interna da tíbia de 15º também não influenciou na força máxima do ligamento cruzado cranial, que foi aproximadamente de 660 Newtons, nem na tensão máxima, que foi cerca de 75 Megapascal. Os retalhos de fáscia lata apresentaram 44% da força máxima e 37% da tensão máxima do ligamento, no entanto, os retalhos torcidos mostraram maior deformação do que os retalhos retilíneos, alcançando cerca de 70% da deformação do ligamento, sendo essa forma a mais indicada na substituição do ligamento cruzado cranial.Bilateral preparations of fascia lata and cranial cruciate ligament from 15 dogs were tested in Instron machine, model 4482. Dogs were from both sexes, between one and four years of age and weighing in average about 11.80 ± 1.99kg. Fascia lata strips were tested straight and twisted and the cranial cruciate ligaments were tested with an angle of 135° between the femur and tibia and 0°, 15° of external tibial rotation and 15° of internal tibial rotation in relation to femur. The traction test velocity was 8.47mm per second. The maximum force of fascia lata strips was of approximately 290 Newtons and the maximum stress, 28 Megapascal. Similar results of strength and stress

  8. Queering Gender: The New Femme Fatale in Almodóvar’s La mala educación (2004

    Directory of Open Access Journals (Sweden)

    Pastor, Brígida M.

    2013-06-01

    Full Text Available It is difficult to define film genres in the post-modern cinema, as they are strongly influenced by the conventions of classic genres. Within this context the emergence of transgressive or “dissident” identities have populated such genres and particularly the creation of a modern femme fatale has become a popular and polemical character in contemporary fiction. This new transgressive identity deviates from its counterpart in classical cinema-film noir. Pedro Almodóvar’s La mala educación (2004 reveals that the modern femme fatale has become at the turn of the twenty-first century an integral part of the queer community, thus proposing a new filmic platform of queering gender for the vindication of the rights of the (“other” stigmatized identities.Es difícil definir los géneros fílmicos en el cine post-moderno, ya que están fuertemente influenciados por los géneros clásicos convencionales. Dentro de este contexto, el surgimiento de identidades transgresivas o “disidentes” ha habitado estos géneros y en particular la creación de una nueva femme fatale se ha convertido en un personaje popular y polémico en la ficción contemporánea. El filme de Pedro Almodóvar, La mala educación (2004, a comienzos del siglo XXI, revela que la nueva femme fatale se ha convertido en una parte integral de la comunidad queer, proponiendo así una nueva plataforma fílmica de género torcido que sirve como vindicación de los derechos de las (“otras” identidades estigmatizadas.

  9. Corruption and Spread of Pathogenic Proteins in Neurodegenerative Diseases*

    Science.gov (United States)

    Walker, Lary C.; LeVine, Harry

    2012-01-01

    With advancing age, the brain becomes increasingly susceptible to neurodegenerative diseases, most of which are characterized by the misfolding and errant aggregation of certain proteins. The induction of aggregation involves a crystallization-like seeding mechanism by which a specific protein is structurally corrupted by its misfolded conformer. The latest research indicates that, once formed, proteopathic seeds can spread from one locale to another via cellular uptake, transport, and release. Impeding this process could represent a unified therapeutic strategy for slowing the progression of a wide range of currently intractable disorders. PMID:22879600

  10. Sweating the small stuff: pitfalls in the use of radiation detection instruments.

    Science.gov (United States)

    Prekeges, Jennifer Lynne

    2014-06-01

    Nuclear medicine technologists use nonimaging radiation detection instruments on a daily basis and routinely assess their performance in several ways. These instruments are simple to operate compared with imaging instruments but are also susceptible to misuse. After reviewing the theoretic basis for common mistakes and the importance of routine quality control, this continuing education article discusses pitfalls in the operation of dose calibrators, survey meters, scintillation detectors, and semiconductors. The article also reviews quality control procedures and ways in which these can be performed incorrectly. The goal of the article is to help technologists to spot and correct problems before they lead to errant results. PMID:24627414

  11. Primer registro de oso negro americano (Ursus americanus) para el estado de Hidalgo, México

    OpenAIRE

    Alberto Enrique Rojas-Martínez; Luis Antonio Juárez-Casillas

    2013-01-01

    Se documenta el primer registro del oso negro americano (Ursus americanus) para el estado de Hidalgo, México, mismo que representa el punto más sureño de la distribución de esta especie. El ejemplar se encontró muerto cerca del poblado El Aguaje de Cerro Prieto en un lugar conocido como La Joya, municipio de La Misión, en el norte del estado, a una altitud de 1 481 m, probablemente correspondía a un individuo errante proveniente del estado de Querétaro.

  12. Bibliographie

    OpenAIRE

    2015-01-01

    Textes et allusions ponctuelles Cartaphile, Boutedieu, Malchus Antonio di Francesco di Andréa, voir Salomone Morpurgo, L’Ebreo errante in ltalia, op. cit., p. 15-40 ; anaJyse et nombreux passages traduits dans Gaston Paris, Légendes du Moyen Age, op. cit., p. 203-220. Guido Bonatti, Introductorius adjudicia stellarum, Augsbourg, 1491, tractat. 5, consideratio 141. Léonard de Clou, Itinerarium breve Terrae Sanctae, Florence, 1891, p. 161. Pietro Della Valle, Viaggi, Rome, 1662, IV, p. 282. Fie...

  13. [Don Quijote, a lucid mad].

    Science.gov (United States)

    Alonso Fernández, Francisco

    2004-01-01

    The case of a 50-year-old hidalgo who believed to be transformed into a knight-errant named Don Quijote is a megalomaniac systematized delusion of transformation of the self, a delusion of metamorphosis in reference to the patient's own identity. The outward projection of this syndrome produces some delusional misidentifications of others, things and animals and include elements of a persecutory delusion which increase the grandiosity of the self. At the same time the hidalgo was maniac with a pathway of bipolar disorder. The phenomenon of donquijotismo is described as the defence of wasted causes and Sancho Panza as an illiterate Sócrates. PMID:15997586

  14. ODISEO CREATIVO: UN CAPÍTULO DE LA HISTORIA REMOTA DE LA CREATIVIDAD

    OpenAIRE

    Ricardo López Pérez

    2010-01-01

    En un remoto pasado, griegos y troyanos se enfrentaron en una extensa lucha. Los primeros sitiaron la ciudad de Troya hasta destruirla a sangre y fuego. La mayoría de los detalles se perdieron, pero nuestra cultura conservó fragmentos importantes gracias a la composición oral y al canto público de poetas errantes de prodigiosa memoria, llamados aedos o rapsodas, que luego fueron la base de textos que aún podemos leer. En el centro de esta historia, emerge la figura del primer pensador creativ...

  15. Energy prices, multiple structural breaks, and efficient market hypothesis

    International Nuclear Information System (INIS)

    This paper investigates the efficient market hypothesis using total energy price and four kinds of various disaggregated energy prices - coal, oil, gas, and electricity - for OECD countries over the period 1978-2006. We employ a highly flexible panel data stationarity test of Carrion-i-Silvestre et al. [Carrion-i-Silvestre JL, Del Barrio-Castro T, Lopez-Bazo E. Breaking the panels: an application to GDP per capita. J Econometrics 2005;8:159-75], which incorporates multiple shifts in level and slope, thereby controlling for cross-sectional dependence through bootstrap methods. Overwhelming evidence in favor of the broken stationarity hypothesis is found, implying that energy prices are not characterized by an efficient market. Thus, it shows the presence of profitable arbitrage opportunities among energy prices. The estimated breaks are meaningful and coincide with the most critical events which affected the energy prices. (author)

  16. Trypanosoma (Herpetosoma) rangeli Tejera, 1920: nota prévia sobre a histopatologia em camundongos infectados experimentalmente

    OpenAIRE

    Cecilia de Scorza; Servio Urdaneta-Morales; Felix Tejero

    1986-01-01

    Ratones machos (cepa NMRI) de 3 y 5 gr, inoculados i.p. con 8 x 10(6) y 9 x 10(4) metatripo- mastigotes/gr cosechados de cultivo LIT de 12 días de repique de la cepa "Perro-82" de Trypanosoma rangeli fueron procesados, em determinados períodos postinoculación, para seccionar y teñir con hematoxilina-eosina y Giemsa-colofonio trozos de corozón, hígado, bazo, pulmones, fémur, riñon, intestino, estómago, cerebro, cerebelo, esternón y columna vertebral. Se detallan los resultados preliminares sob...

  17. Base molecular del dopaje con proteínas recombinantes. Eritropoyetina. Revisión bibliográfica.

    OpenAIRE

    García Verdes, Alberto

    2013-01-01

    La eritropoyetina es una glicoproteína acídica compuesta por 165 aminoácidos, sintetizada mayoritariamente en los riñones y en menor medida en la médula ósea, el bazo y el hígado. Gracias al desarrollo de la ingeniería genética, cada vez es más habitual la presencia de esta proteína tanto en el ámbito sanitario, como en el deportivo siendo utilizada como método de dopaje. En el presente trabajo, se estudia la estructura, biosíntesis, función de la proteína, sus diferentes indicaciones clín...

  18. Toxicidad de VA-DIFTET® por administración a dosis repetida en ratones

    Directory of Open Access Journals (Sweden)

    Pablo González

    2000-06-01

    Full Text Available Una vez estudiada la toxicidad de la vacuna VA-DIFTET® (vacuna antidiftérica antitetánica por administración a dosis única en dos especies de animales, se impone la evaluación a dosis repetida, teniendo en cuenta que el esquema de inmunización en humanos prevé la aplicación de tres dosis cuando el componente pertusis de la DPT está contraindicado. Se emplearon 210 ratones OF-1 de ambos sexos. Los grupos experimentales fueron similares a los de la prueba a dosis única con la vacuna dúplex, anatoxina diftérica, anatoxina tetánica, adyuvante, tiomersal, solución salina fisiológica y un grupo control no tratado. Un grupo de hembras y otro de machos fue asignado aleatoriamente a cada tratamiento y para recibir 1, 2 ó 3 dosis por vía intramuscular. Tras cada aplicación se evaluó la aparición de síntomas clínicos, el incremento de peso, el consumo de agua y alimento y la dinámica de la respuesta inmune contra las anatoxinas tetánica y diftérica, específicamente de tipo IgG, mediante ELISA indirecto. Al término de las observaciones los animales fueron sacrificados y se realizaron estudios anatomopatológicos. Además, durante el sacrificio se evaluó el índice relativo de bazo y timo, así como la relación bazo/timo. No se comprobaron alteraciones que evidenciaran toxicidad por parte de la vacuna y sus componentes. Asimismo, se demostró una marcada respuesta inmune en los grupos vacunales e inoculados con las anatoxinas. Se considera que los resultados de la prueba fueron satisfactorios.

  19. Brote urbano de leishmaniasis visceral en Neiva, Colombia

    Directory of Open Access Journals (Sweden)

    Pilar Zambrano-Hernandez

    2015-07-01

    Full Text Available Objetivo Estudiar clínica y epidemiológicamente focos de leishmaniasis visceral (LV urbana en Neiva (Colombia. Materiales y Métodos Seis niños consultaron por hepato-esplenomegalia. Presentaban anemia y leucopenia. Se realizó biopsia por aspiración de medula ósea (5 pacientes y de bazo (1 paciente. Se hizo búsqueda activa de casos en la comunidad y de anticuerpos anti-Leishmania infantum por inmunofluorescencia indirecta (IFI en los sintomáticos y en reservorios caninos (IFI, rK39. Se hicieron visitas domiciliarias para educación comunitaria y búsqueda de vectores. Los pacientes recibieron Miltefosina, Anfotericina B o Glucantime®. Resultados Se confirmó LV en siete niños. En seis, el aspirado de medula ósea o bazo demostró amastigotes. La IFI fue positiva en 4 pacientes y negativa en 3. Un niño se detectó por búsqueda activa comunitaria, con clínica de LV, confirmada por IFI (1:32. La miltefosina no fue útil en 6 de los 7 casos. La Anfotericina B liposomal o deoxicolato, curó 6 pacientes y el Glucantime® uno. La seroprevalencia en 1182 caninos (IFI y rK39 fue de 6.1 %; los animales positivos fueron sacrificados. Se demostró Lu. longipalpis, vector de LV, en el peridomicilio. Conclusiones Demostramos LV urbana en dos comunas de Neiva. La confirmación diagnóstica incluyó aspiración de medula ósea e IFI. La Miltefosina no fue útil. La Anfotericina B liposomal fue la terapia ideal. Para controlar la LV es necesario hacer BAC, educación comunitaria, control de vectores y reservorios.

  20. Effects of multiple background talkers on word recognition and response awareness

    Science.gov (United States)

    Goshorn, Edward L.; Robertson, Elizabeth K.

    2003-04-01

    Effects of background talkers (0, 1, 2, 3, 4, 5, 7, 10, and 14) on word recognition and awareness of errant/accurate responses were examined. Diagnostic Rhyme Test (DRT) words and background talkers were presented at 70 dB SPL (sound field) to ten normal-hearing subjects. DRT words and background talkers were digitally processed to produce equal VU meter levels. Three replicates were obtained for each condition. Performance measures were: (1) percent correct, corrected for guessing, transformed to rational arcsine units (PCGRAU); (2) subject's awareness of accurate responses (AA); (3) subject's awareness of errant responses (AE); and (4) a geometric-based symmetric awareness (SA). Awareness measures were derived from subject's confidence ratings to DRT stimuli. Both informational and direct masking effects were present. PCGRAU varied nonlinearly as number of talkers increased. One talker provided significantly more masking than two talkers and was equally effective as three, four, five, seven, and ten talkers as well as speech-spectrum noise. Fourteen talkers provided the most masking and was equally effective as white noise. In general, AA tended to diminish while AE tended to improve as additional background talkers were added. SA was best for 14-talker background noise but poorest for one-talker and speech-spectrum noise.

  1. Partitioning of Habitat and Prey by Abundant and Similar-sized Species of the Triglidae and Pempherididae (Teleostei) in coastal waters

    Science.gov (United States)

    Platell, M. E.; Potter, I. C.

    1999-02-01

    The aim of this study was to determine whether certain co-occurring and abundant species of the teleost families Triglidae and Pempherididae are segregated spatially and/or by diet, and are thus less likely to be susceptible to competition for resources. Nocturnal otter trawling in shallow (5-15 m) and deeper (20-35 m) waters in four regions along ˜200 km of the south-western Australian coastline collected large numbers of a wide size range of the triglids Lepidotrigla modestaand Lepidotrigla papilioand the pempheridids Pempheris klunzingeriand Parapriacanthus elongatus. Although these four species frequently co-occurred at several sites, each species attained its highest density at different sites, thereby representing a partial segregation of these species by habitat. This even occurred with the congeneric triglid species, with L. modestabeing most abundant in the four deep, offshore sites, while L. papiliowas most numerous at three sites which varied in depth and distance from shore. Although triglids and pempheridids both consumed substantial amounts of amphipods and mysids, only the members of the latter family ingested a large amount of errant polychaetes. The latter difference is assumed to reflect the fact that, in comparison with triglids, pempheridids can swim faster, have a mouth adapted for feeding upwards in the water column and feed at night when errant polychaetes emerge from the substratum. Although the dietary compositions of L. modestaand L. papiliodid not differ significantly when analyses were based on dietary data for all sites, they did differ significantly when analyses were restricted to dietary data obtained when both species were abundant and co-occurred. The likelihood of competition for food is thus reduced in the latter circumstances. In comparison with P. klunzingeri, P. elongatusconsumed a relatively larger volume of amphipods and a relatively smaller volume of mysids, which are more mobile, implying that P. elongatusfeeds to a

  2. Studies on the effect of vanillin (food additive on some metabolic reactions of the experimental animals

    Directory of Open Access Journals (Sweden)

    El-Massry, R. A.

    1991-12-01

    función hepática (S.GOT, S.GPT, alcalina y ácido fosfatasa así como las funciones renales se elevaron en comparación con el grupo control. La administración de vanillina redujo significativamente los lípidos totales de hígado y riñones. El bazo y corazón siguieron la misma tendencia pero con efecto moderado, mientras que el cerebro no se afectó. El colesterol total en hígado, riñones, bazo y corazón disminuyó significativamente, en tanto que en cerebro no se afectó. Los triglicéridos disminuyeron significativamente en hígado y bazo, mientras que no se alteraron en riñones y cerebro. También hubo una disminución significativa en la alta actividad de S.GOT, S.GPT, alcalina y fosfatasa acida y se alcanzaron valores muy próximos al nivel inicial. La administración de vanillina ejerció efectos anabólicos potentes para el metabolismo de proteínas como se demuestra de los resultados del ácido urónico y creatinina.

  3. ToF-SIMS PC-DFA analysis of prostate cancer cell lines

    International Nuclear Information System (INIS)

    Three closely related cancer cell lines have been analysed with ToF-SIMS using a C60+ primary ion beam. Principal component-discriminant function analysis (PC-DFA) has been applied for spectral classification. Various spectral pre-processing methods are discussed and assessed for optimum discrimination of this data set. The sum-normalised PC-DFA spectral model produced sensitivities as high as 83.3% and specificities as high as 100% at the 99% confidence limit. At this confidence limit only one errant spectrum was misclassified. The resulting loadings plots suggest that a range of lipid and amino-acid related signals are responsible for the cell line discrimination.

  4. End of a Dark Age?

    CERN Document Server

    Stuckey, W M; Sten, A K; Silberstein, Michael

    2016-01-01

    We argue that dark matter and dark energy phenomena associated with galactic rotation curves, X-ray cluster mass profiles, and type Ia supernova data can be accounted for via small corrections to idealized general relativistic spacetime geometries due to disordered locality. Accordingly, we fit THINGS rotation curve data rivaling modified Newtonian dynamics, ROSAT/ASCA X-ray cluster mass profile data rivaling metric-skew-tensor gravity, and SCP Union2.1 SN Ia data rivaling $\\Lambda$CDM without non-baryonic dark matter or a cosmological constant. In the case of dark matter, we geometrically modify proper mass interior to the Schwarzschild solution. In the case of dark energy, we modify proper distance in Einstein-deSitter cosmology. Therefore, the phenomena of dark matter and dark energy may be chimeras created by an errant belief that spacetime is a differentiable manifold rather than a disordered graph.

  5. The Monster and the Mother:The Symbolism of Disaster

    Institute of Scientific and Technical Information of China (English)

    SUSANNA MHoffman; ZHAO Yuzhong

    2013-01-01

    Whether a society encompasses few people or multitudes , whether its landhold is remote and its records without letters or its reach global and its renown etched in ink , disaster con-tradicts its members ’ definitive knowledge . No matter if the disaster stems from nature or errant technology , is experienced or merely expected , no one, neither sage nor scientist , preacher nor presi-dent , can wholly tell the why or the where of a ca-lamitous event .And so, no matter what place in the world it occurs , what form it might take , whether singular or chronic , peoples’ explanations of disaster tend to rely on creative , often mytholog-ical, imagination.The belief systems of people ex-periencing or expecting calamity are rife with sym-bols dealing with their situations , and their cosmol-ogies are vibrant with metaphor .

  6. Factors in selecting serum samples for use in determining the positive/negative threshold (cut-off) in ELISA

    International Nuclear Information System (INIS)

    The threshold (cut-off) that defines whether a test result is seropositive or seronegative is calculated by testing serum samples from a subpopulation of animals that is assumed to represent the target population in all aspects. For this proposition to be true, it is essential to consider the variables in the target population that must be represented in the subpopulation. Without representation of the variables in the subpopulation, it is likely that the cut-off selected for the test will be errant and will misclassify animals as to their infection status. The purpose of this paper is to identify a few of the principal variables that need to be taken into account when selecting a subpopulation of animals for test validation. (author)

  7. An Autonomous Flight Safety System

    Science.gov (United States)

    Bull, James B.; Lanzi, Raymond J.

    2007-01-01

    The Autonomous Flight Safety System (AFSS) being developed by NASA s Goddard Space Flight Center s Wallops Flight Facility and Kennedy Space Center has completed two successful developmental flights and is preparing for a third. AFSS has been demonstrated to be a viable architecture for implementation of a completely vehicle based system capable of protecting life and property in event of an errant vehicle by terminating the flight or initiating other actions. It is capable of replacing current human-in-the-loop systems or acting in parallel with them. AFSS is configured prior to flight in accordance with a specific rule set agreed upon by the range safety authority and the user to protect the public and assure mission success. This paper discusses the motivation for the project, describes the method of development, and presents an overview of the evolving architecture and the current status.

  8. Tiempo y memoria en la poesía de José Emilio Pacheco

    Directory of Open Access Journals (Sweden)

    Carmen Virginia Carrillo-Torea

    2014-10-01

    Full Text Available La poesía de José Emilio Pacheco se caracteriza por una constante reflexión acerca del tiempo. En este trabajo analizo cómo esta preocupación —común a pensadores como Bergson, Bachelard, Barthes y Ricoeur— se hace palabra en sus poemarios Irás y no volverás y La arena errante. El ser humano vive la ilusión de preservar los instantes, de hacerlos trascender; en los poemas, la fugacidad de la existencia y el cambio perpetuo que experimenta el hablante se contraponen al deseo de permanencia en el arte y la escritura.

  9. Anestesia epidural cranial com lidocaína e morfina para campanhas de castração em cães Cranial epidural anesthesia with lidocaine and morphine for sterilization campaign in dogs

    OpenAIRE

    Renato Batista Tamanho; Nilson Oleskovicz; Aury Nunes de Moraes; Fabíola Niederauer Flôres; Ademar Luiz Dallabrida; Doughlas Regalin; Ruiney Carneiro; Acácio Duarte Pacheco; Ademir Cassiano da Rosa

    2010-01-01

    A castração de machos e fêmeas tem sido preconizada como a principal técnica para redução do grande número de cães errantes. No entanto, vários são os entraves com relação à escolha do melhor protocolo anestésico, em relação à eficácia, segurança e redução de custos. Objetivou-se, com este trabalho, avaliar os efeitos cardiorrespiratórios, hemogasométricos e analgésicos da utilização de lidocaína em um volume maior, associada à morfina, pela via epidural em cadelas submetidas à ovariosalpingo...

  10. Responding to Mechanical Antigravity

    Science.gov (United States)

    Millis, Marc G.; Thomas, Nicholas E.

    2006-01-01

    Based on the experiences of the NASA Breakthrough Propulsion Physics Project, suggestions are offered for constructively responding to proposals that purport breakthrough propulsion using mechanical devices. Because of the relatively large number of unsolicited submissions received (about 1 per workday) and because many of these involve similar concepts, this report is offered to help the would-be submitters make genuine progress as well as to help reviewers respond to such submissions. Devices that use oscillating masses or gyroscope falsely appear to create net thrust through differential friction or by misinterpreting torques as linear forces. To cover both the possibility of an errant claim and a genuine discovery, reviews should require that submitters meet minimal thresholds of proof before engaging in further correspondence; such as achieving sustained deflection of a level-platform pendulum in the case of mechanical thrusters.

  11. Lecturas de un Clown

    OpenAIRE

    Eric De Bont

    2012-01-01

    Quedé realmente sorprendido por la invitación de Álabe para escribir un relato sobre la influencia de la lectura en mi vida. A decir verdad, la invitación me vino un poco mal, entre las presentaciones finales de la escuela y la preparación de mi viaje de dos meses a Cerdeña y la Toscana.Yo, como holandés errante, tendría que escribir algo sobre un sinfín de escritores y libros de literatura holandesa. Por eso me gustaría escribir este texto como un documento personal, de qué manera la literat...

  12. Prevalência de anticorpos para o vírus da Influenza Eqüina, subtipo H3N8, em eqüídeos apreendidos no Estado do Rio de Janeiro Antibody prevalence of Equine Influenza virus, subtype H3N8, in equids apreehend on Rio de Janeiro State, Brazil

    OpenAIRE

    Gabrielle Sales de Oliveira; Paula Amorim Schiavo; Carlos Mazur; Cláudio de Moraes Andrade

    2005-01-01

    O vírus Influenza A, subtipo H3N8, é o agente etiológico da Influenza Eqüina, responsável por diversas epidemias e endemias respiratórias em nível mundial, inclusive no Estado do Rio de Janeiro, Brasil. O objetivo deste trabalho foi avaliar a importância de eqüídeos errantes, como fontes de infecção do vírus Influenza, subtipo H3N8. A enquete foi realizada a partir da pesquisa de anticorpos específicos para este vírus em 1106 soros analisados através da prova de inibição da hemaglutinação. O ...

  13. ‘Um pensamento insone’: os perigos do símbolo em Moby Dick, de Herman Melville

    Directory of Open Access Journals (Sweden)

    André Cechinel

    2014-12-01

    Full Text Available Este artigo investiga a instabilidade dos símbolos em Moby Dick, de Herman Melville, e o perigo que a leitura simbólica representa tanto para os marujos do Pequod, navio capitaneado por Ahab, quanto para os leitores do romance. Se Ishmael, por um lado, habita as fronteiras do texto e por isso converte-se na única testemunha possível do naufrágio, ou seja, aquela que apaga seus traços identitários para poder narrar o que vivenciou, Ahab, por outro lado, investe na suposta concretude dos símbolos e, assim, desfaz-se juntamente com a dissolução do sentido primeiro atribuído à busca pela baleia branca, Moby Dick. Com o naufrágio do Pequod, o símbolo explicativo submerge para dar lugar a uma textualidade errante.

  14. acuoso liofilizado de Ocimum tenuiflorum L

    Directory of Open Access Journals (Sweden)

    A Lagarto

    2005-01-01

    Full Text Available El potencial tóxico de un extracto acuoso liofilizado fue evaluado mediante el ensayo de toxicidad aguda oral y subcrónica a 90 días en ratas Wistar de ambos sexos. Los métodos empleados fueron los descritos por las normas OECD. En el ensayo agudo se administró por vía oral la dosis de 2000 mg/kg y en el ensayo subcrónico 250, 500 y 1000 mg/kg/día durante 13 semanas. Se evaluaron los signos tóxicos y peso corporal en ambos ensayos. En el estudio subcrónico además se evaluó el consumo de alimentos, indicadores hematológicos (hemoglobina, hematocrito, recuento diferencial de leucocitos, recuento total de leucocitos y recuento total de eritrocitos y bioquímica clínica (glucosa, alanino amino transferasa, aspartato amino transferasa, colesterol, urea, bilirrubina y creatinina. También se realizó necropsia y examen histopatológico de órganos y tejidos (corazón, riñón, hígado, bazo, cerebro, pulmón, estómago, intestino, timo, glándulas suprarrenales, tiroides, paratiroides, páncreas, glándulas salivales, ganglio cervical, testículos, vesículas seminales, próstata y ovarios y se determinó el peso relativo de órganos (corazón, riñón, hígado, bazo, cerebro, pulmón, timo, glándulas suprarrenales, próstata, testículos y ovarios. No se apreciaron signos tóxicos ni mortalidad como consecuencia de la administración del liofilizado de Ocimum tenuiflorum L. en ninguno de los ensayos. Los parámetros analizados de peso corporal, consumo de alimentos, hematología, bioquímica, peso relativo de órganos y análisis histopatológico de órganos y tejidos no evidenciaron toxicidad significativa atribuible a la sustancia de prueba

  15. Comparative neuroanatomy suggests repeated reduction of neuroarchitectural complexity in Annelida

    Directory of Open Access Journals (Sweden)

    Todt Christiane

    2010-05-01

    Full Text Available Abstract Background Paired mushroom bodies, an unpaired central complex, and bilaterally arranged clusters of olfactory glomeruli are among the most distinctive components of arthropod neuroarchitecture. Mushroom body neuropils, unpaired midline neuropils, and olfactory glomeruli also occur in the brains of some polychaete annelids, showing varying degrees of morphological similarity to their arthropod counterparts. Attempts to elucidate the evolutionary origin of these neuropils and to deduce an ancestral ground pattern of annelid cerebral complexity are impeded by the incomplete knowledge of annelid phylogeny and by a lack of comparative neuroanatomical data for this group. The present account aims to provide new morphological data for a broad range of annelid taxa in order to trace the occurrence and variability of higher brain centers in segmented worms. Results Immunohistochemically stained preparations provide comparative neuroanatomical data for representatives from 22 annelid species. The most prominent neuropil structures to be encountered in the annelid brain are the paired mushroom bodies that occur in a number of polychaete taxa. Mushroom bodies can in some cases be demonstrated to be closely associated with clusters of spheroid neuropils reminiscent of arthropod olfactory glomeruli. Less distinctive subcompartments of the annelid brain are unpaired midline neuropils that bear a remote resemblance to similar components in the arthropod brain. The occurrence of higher brain centers such as mushroom bodies, olfactory glomeruli, and unpaired midline neuropils seems to be restricted to errant polychaetes. Conclusions The implications of an assumed homology between annelid and arthropod mushroom bodies are discussed in light of the 'new animal phylogeny'. It is concluded that the apparent homology of mushroom bodies in distantly related groups has to be interpreted as a plesiomorphy, pointing towards a considerably complex

  16. Prevalência de anticorpos para o vírus da Influenza Eqüina, subtipo H3N8, em eqüídeos apreendidos no Estado do Rio de Janeiro Antibody prevalence of Equine Influenza virus, subtype H3N8, in equids apreehend on Rio de Janeiro State, Brazil

    Directory of Open Access Journals (Sweden)

    Gabrielle Sales de Oliveira

    2005-10-01

    Full Text Available O vírus Influenza A, subtipo H3N8, é o agente etiológico da Influenza Eqüina, responsável por diversas epidemias e endemias respiratórias em nível mundial, inclusive no Estado do Rio de Janeiro, Brasil. O objetivo deste trabalho foi avaliar a importância de eqüídeos errantes, como fontes de infecção do vírus Influenza, subtipo H3N8. A enquete foi realizada a partir da pesquisa de anticorpos específicos para este vírus em 1106 soros analisados através da prova de inibição da hemaglutinação. O elevado percentual (35,9% de animais soropositivos encontrados evidencia seu papel como uma importante fonte de infecção deste vírus para o rebanho eqüino nacional.The Influenza virus type A, subtype H3N8, is the etiological agent of the Equine Influenza, responsible for several epidemics and endemic respiratory diseases in world level, besides in the Rio de Janeiro State, Brazil. The objective of this work was to evaluate the role of errant equids, as infectious sources of the Influenza virus, subtype H3N8. The survey was performed from the research of specific antibodies for this virus in 1106 sera analyzed by the inhibition of the hemagglutination test. The high percentile (35,9% of seropositive animals found in this study evidenced its importance as infectious sources of the Influenza virus, subtype H3N8, to the national equine flock.

  17. LINFOSARCOMA CANINO

    Directory of Open Access Journals (Sweden)

    Iang Rondón Barragán

    2006-12-01

    Full Text Available Un canino criollo hembra de 5 años de edad fue llevado a la clínica veterinaria de la universidadde los llanos, con historia de anorexia y con una lesión en la región frontal de la cara. El análisishematológico mostró anemia leve, neutropenia acompañada de linfocitosis marcada. En la necropsiase evidenció hepatomegalia y congestión hepática, esplenomegalia, congestión de vasosmesentéricos, la cápsula renal se desprendió con facilidad y la periferia renal presentaba zonas debajo relieve así como zonas pálidas en la corteza. Los resultados histopatológicos mostraronhallazgos compatibles con linfosarcoma que se clasificó como grado IV, con metástasis en hígadoriñón y bazo. La distribución de la neoplasia encontrada es compatible con linfoma hepatoesplénico;en el cual se demostró la distribución de células neoplásicas que reflejaron un tropismo vascular yla lesión cutánea en la frente pudo ser resultado primario o secundario del linfosarcoma; la patologíafue compatible con microabscesos de Pautrier.

  18. Consumo de arsénico y riesgo cardiovascular

    Directory of Open Access Journals (Sweden)

    Lachiner Saborío Morales

    2015-03-01

    Full Text Available El arsénico (As es un elemento considerado como ubicuo, cuyas fuentes pueden ser naturales o productos de la actividad humana. La exposición a este elemento ocurre principalmente por la vía oral. Las presentaciones inorgánicas del As son consideradas como las más tóxicas. La absorción del As ocurre en el intestino delgado y por medio de acuaporinas ingresa a los hepatocitos, en casos de ingesta crónica el As tiende acumularse en hígado, riñones, corazón, sistema nervioso, pulmones, músculo, tracto gastrointestinal y bazo. El consumo crónico de agua con concentraciones de As por encima del valor de referencia dado por la Organización Mundial de la Salud (OMS ha demostrado un aumento del riesgo de accidentes vasculares cerebrales (AVC, hipertensión arterial (HTA, aterosclerosis carotidea, enfermedades arteriales periféricas, mortalidad por infarto agudo del miocardio (IAM, aumento en enfermedades cardiovasculares en la población pediátrica y diabetes mellitus tipo II.

  19. Tuberculosis congénita. Informe de un caso con autopsia.

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    Armando Cortés

    2009-10-01

    Full Text Available La tuberculosis congénita es una enfermedad rara, de diagnóstico correcto difícil con base tan sólo en las manifestaciones clínicas y sin tener una historia materna disponible. Se presenta el caso de una autopsia de un recién nacido de 56 días, producto de una madre de raza negra, sin control prenatal y de muy bajos recursos económicos. El neonato tuvo succión pobre, llanto débil, hidrocefalia y poco desarrollo, lo que simulaba una sepsis neonatal y enterocolitis necrotizante. La autopsia revela tubérculos miliares generalizados en cerebro, hígado, bazo, páncreas, glándulas suprarrenales, tiroides, ganglios linfáticos, riñón, corazón, músculo esquelético y pulmón. Luego la madre presenta una pneumonitis y se pudo aislar Mycobacterium tuberculosis.

  20. Síndrome de Hunter Mucopolisacaridosis (II:reporte de un caso

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    Ghunter Paz

    2011-06-01

    Full Text Available El síndrome de Hunter, es una alteración genética que afecta principalmente a los varones, debido a la deficiencia o ausencia de la enzima iduronato-2-sulfatasa, que interfiere con lacapacidad del cuerpo de descomponer y reciclar los mucopolisacáridos. La incidencia es de 1:10.000 a 1:25.000 de recién nacidos vivos. Las manifestaciones físicas, incluyen rasgos faciales distintivos, cabeza grande, abdomen aumentado, engrosamiento de válvulas cardíacas, enfermedad respiratoria obstructiva, retraso del desarrollo mental y aumento de tamaño del hígado y del bazo.Presentamos el caso clínico de un paciente de sexo masculino de 7 años de edad, con diagnostico de síndrome de Hunter hace seis años, con antecedentes de crisis convulsivas en dos oportunidades y cuadros de bronconeumonía.Al examen físico presenta fascie tosca, contractura en musculo bíceps braquial, se logra la extensión de las manos, camina con la punta de los pies y presenta hepato y esplenomegalia. Al cual se le trató la sintomatología respiratoria con el uso de antibióticos.

  1. Modelização e estudo experimental de óxidos multiferróicos

    CERN Document Server

    Fenta, Abel

    The main goal of this work was the theoretical and experimental study of multiferroics oxides. This particular approach focused mainly on the ferroelectric material barium titanate. The essence of this theoretical study is the ab initio calculation of hiperfine parameters using the Wien2k software. This software, which uses the selfconsistent $LAPW$ method to solve the Kohn-Sham equations, allowed to determine the electric field gradient and the BaTiO$_3$ system’s total energy in its different structural phases, and study its behaviour in function of the different lattice parameters. The modeling of stratified systems of the (XTiO$_3$).(BaTiO$_3$)$_{n-1}$ and (BaZO$_3$).(BaTiO$_3$ )$_{n-1}$, with X=Cd and Hg and Z=Fe, from n=2 to n=6 type, built from the experimental latice parameters (formula) in the tetragonal sage was also made. This simulation can be related to the physical situation of the epitaxial growth of XTiO$_3$ a layer on n BaTiO$_3$ layers. It was also studied the effect of the Cd ion volume di...

  2. Composición y distribución espacio-temporal de las comunidades de arañas (Arachnida: Araneae en el sistema de cultivo maíz-soya de la altillanura plana colombiana, municipio de Puerto López, Meta

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    Flórez Daza Eduardo

    2004-12-01

    ñas pertenecientes a 125 morfoespecies y 19 familias. La familia más abundante fue Oxyopidae (41% y dentro
    de esta familia la especie Oxyopes salticus Hentz representó el 98,5%, equivalente al 40% del total de arañas colectadas. Siguieron en importancia de abundancia las familias Lycosidae (26% y Araneidae (13%. Esta última representó la mayor riqueza, con 26 morfoespecies (21%. Los gremios de arañas encontrados dentro del agroecosistema fueron: errantes en follaje, errantes en suelo, tejedoras orbiculares y tejedoras irregulares. Durante todas las etapas del cultivo y en los diferentes ecosistemas evaluados, el gremio dominante por su abundancia (57% y diversidad fue el de las arañas errantes en follaje. Estos organismos, principalmente la especie O. salticus, resultan promisorios para la regulación de poblaciones de insectos plaga en este
    sistema. La composición y diversidad de arañas en términos generales no se ve afectada durante las diferentes etapas del sistema de cultivo, pero sí entre los ecosistemas aledaños, los cuales promueven un aumento en la diversidad dentro de los cultivos y además determinan la fauna de arañas que se dispersa hacia estos.

  3. Contribución al control de Botrytis cinerea pers. en statice (Limonium sinuatum mill variedad Midnigth blue

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    Díaz Norma C.

    1996-12-01

    eficiencia de los fungicidas Iprodione (Rovral y Captan (Orthocide, sobre los patógenos y el antagonista,
    determinaron las dosis letales de estos (1 ml/lt , evaluados en los tratamientos químico e integrado. En campo se realizó el montaje de los tratamientos (biológicos, químicos e integrado, para encontrar el más eficaz en el control de los patógenos. La efectividad de los tratamientos se evaluó teniendo en cuenta la producción de ramos de exportación
    (550-560 gr; ramos nacionales (tallos torcidos. decolorados; y ramos perdidos por enfermedad. El tratamiento integrado fue el mejor, con una producción de 1.8 ramos/planta, seguido del tratamiento químico, con 1.62 ramos/planta. Los ramos perdidos por enfermedad fueron de 0.14 ramos/planta en el tratamiento Integrado y de 0.26 ramos/planta en los tratamientos químico-biológico y químico-cultural. El tratamiento con menor productividad fue el químico-cultural con una producción de 1.42 ramos/planta.

  4. Utilización del cobre en dietas hipograsas

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    Aguirre, M.

    1996-12-01

    contenidos corporales iniciales y finales del elemento y en la última semana por control de la ingesta y la excreción fecal del micronutriente. Se controló también el peso y los contenidos de cobre en carcasa, hígado, bazo, piel, eritrocitos y suero. Las dietas hipograsas mermaron la utilización del cobre mediante una disminución de su ingesta y también por deterioro de la biodisponibilidad del elemento en ellas. Se deprimió su contenido corporal total, el del bazo y el del hígado y las concentraciones en este último órgano, en la piel y en el suero. El aceite de palma (fracción oleína (8%, frente a los otros dos, produjo un descenso en la digestibilidad del cobre.

  5. The Construction of a Database to Support the Compilation of Japanese Learners’ Dictionaries

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    Yuriko SUNAKAWA

    2012-10-01

    Full Text Available The number of Japanese language learners outside Japan, especially of advanced level learners, is increasing yearly. From the intermediate level onwards, they could profit from bilingual Japanese learners’ dictionaries in their native language, but in most linguistic areas of the world only very simple dictionaries for beginners and for tourists are available. Our project therefore aims at supporting the compilation of Japanese language learners’ dictionaries for intermediate and advanced learners by building a database of contents needed when editing a Japanese language learners’ dictionary, and offering it online. This 4 year project is going to be running from 2011 to 2014. Two surveys were conducted: a survey of the vocabulary used in textbooks of Japanese as a foreign language and a quantitative survey on the targeted area of the Japanese language in a large-scale corpus, in order to select the list of words to be included in the database, and a general list of basic vocabulary for Japanese language instruction was created. At present, usage examples are being compiled on the basis of this vocabulary list, and a database system is being developed. A prototype of a database search interface and download system has been completed. The database is going to include various types of information which are considered to be useful for learners, such as grammar, phonetics, synonyms, collocations, stylistics, learners’ errors etc. These are presently being studied in detail to be made public in 2014.-----Število učencev in študentov japonskega jezika zunaj Japonske, posebej na višjih nivojih, narašča iz leta v leto. Od srednjega nivoja dalje so za učenje koristni dvojezični učni slovarji, ki vključujejo uporabnikov materni jezik, a za večino jezikov na svetu obstajajo le zelo preprosti slovarji za začetnike ali za turiste. Zato je cilj tega projekta sestaviti bazo podatkov, ki so potrebni v učnem slovarju japonščine, in jo

  6. Efecto de la melatonina sobre la concentración de péptidos opioides en el sistema inmune de la rata (parte a

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    Marcela Valdés Tovar

    2003-01-01

    Full Text Available La fisiología de la melatonina (MEL se asocia con la regulación del sistema inmune. La inhibición farmacológica de la síntesis de MEL disminuye la respuesta humoral primaria desencadenada por un estímulo antigénico. Asimismo, la administración exógena de MEL antagoniza los efectos inmunosupresores de la corticosterona y del estrés agudo. La MEL induce la liberación de interleucina-12 a partir de los monocitos, lo que a su vez promueve la diferenciación de los linfocitos TH1. En estos linfocitos, la MEL estimula la liberación de interleucina-2 e interferón-γ. Los receptores de la MEL presentes en la membrana plasmática y en el núcleo de los monocitos y los linfocitos son los responsables de producir la acción de la hormona. Se ha sugerido que el efecto inmunoestimulante de la MEL se produce por un mecanismo mediado por los péptidos opioides. Los linfocitos, los monocitos y las células polimorfonucleares producen y liberan péptidos opioides. En el SNC de la rata, la ausencia de MEL endógena rompe el ritmo circádico de las encefalinas y disminuye su concentración. Si la inhibición fisiológica de la síntesis endógena de MEL disminuye la concentración y liberación de encefalinas en el SNC de la rata, es factible suponer que el contenido de estos péptidos disminuye también en las células del sistema inmune. Por lo tanto, el objetivo de este trabajo fue estudiar la concentración de encefalinas en el bazo y el timo de la rata, en ausencia y presencia de melatonina. Los resultados obtenidos en el presente trabajo demuestran que en ausencia de MEL endógena se produjo una disminución significativa en la concentración de Met-encefalina, Leu-encefalina, Octapéptido y Heptapéptido en los órganos del sistema inmune. Por el contrario, en animales sometidos a luz continua a los cuales se administró MEL en forma exógena, el contenido de los cuatro péptidos aumentó significativamente tanto en el bazo como en el timo

  7. Toxicidad por dosis repetidas de la solución CM-95 tratada magnéticamente en ratas Sprague Dawley

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    Clara E. Martínez

    2008-08-01

    Full Text Available En este trabajo se realizó la evaluación toxicológica a dosis repetidas por el método de test límite del candidato a inmunopotenciador, la solución CM-95 tratada magnéticamente, acorde con las regulaciones de la Organización para la Colaboración Económica y el Desarrollo, incluida en la Guía 407. El objetivo fue establecer las posibles lesiones orgánicas y funcionales ocasionadas por la solución CM-95, tratada magnéticamente con la máxima inducción magnética permisible (0,16 T, para la obtención del candidato a inmunopotenciador. Se emplearon tres grupos: Experimental, Control y Satélite. Como Biomodelo experimental se utilizaron ratas Sprague Dawley machos y hembras con pesos de 150 a 200 g. Durante el estudio no se registraron signos clínicos de toxicidad ni muertes en ninguno de los animales de los grupos tratados, ni en los controles. No hubo afectación del peso corporal durante el ensayo. Aunque hubo variaciones en los valores de algunos parámetros hematológicos y bioquímicos, estos no tuvieron significación biológica. No se encontraron lesiones macroscópicas, ni microscópicas; solo se observaron efectos proliferativos en el tejido linfoide de timo y bazo, relacionados con la respuesta del sistema inmune. La solución CM-95 tratada magnéticamente, no mostró toxicidad en el modelo animal y nivel de dosis utilizado, y bajo las condiciones experimentales ensayadas.

  8. CARCINOMA COMPLEJO DE GLÁNDULA MAMARIA, ACANTOMA QUERATINIZANTE INFUNDIBULAR Y MASTOCITOMA TIPO III EN UN CANINO

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    Ochoa-Amaya JE

    2009-12-01

    Full Text Available Entre las neoplasias, los tumores de piel son considerados los más frecuentes en Medicina Veterinaria. El acantoma queratinizante infundibular (AQI es el tumor menos común de las neoplasias foliculares, en contraste, el mastocitoma (MC es el tumor más común de las neoplasias mesenquimales en perros, asimismo, los tumores mamarios caninos constituyen la neoplasia más frecuente en la hembra (25 a 50% de todos los tumores siendo del 41 al 50% de ellos malignos. El presente caso clínico busca documentar los hallazgos anatomopatológicos correspondientes a la presentación conjunta e infrecuente de tres neoplasias cutáneas en una perra. Se presenta el caso de un canino, hembra de 11 años de edad, cruce de raza Poodle, que fue llevada a consulta por emesis 15 días atrás y por la presencia de masas en el abdomen y en glándula mamaria. El paciente es eutanasiado. A la necropsia se hallaron masas múltiples redondeadas de variados tamaños tanto en la piel del abdómen y de glándula mamaria, así como en el parénquima del bazo e hígado. Las muestras de tejidos fueron fijadas en formalina buferada al 10% y llevadas al laboratorio para su procesamiento por técnicas histológicas rutinarias. Se diagnosticó carcinoma complejo de glándula mamaria, un MC tipo III metastásico y un AQI. Se demostró la presentación de dos neoplasias cutáneas malignas y una benigna en un mismo animal y se reportó la aparición simultánea e infrecuente del MC asociado al AQI.

  9. Valoración de parámetros clínicos y lesiones en órganos de cerdos durante el período posdestete

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    Rincón Ruiz Juan

    2012-03-01

    Full Text Available El destete de cerdos estã asociado con multiples factores que generan respuestas infiamatorias tem- pranas en órganos internos y alta incidencia de diarreas. En el Centro de Investigación San Pablo de la Universidad Nacional de Colombia sede Medellín, se evaluaron los parámetros clínicos y las lesiones en órganos internos en dieciséis cerdos destetados a veintiún días de edad, que fueron alimentados durante diez días con una dieta a base de leche. Cada uno, cinco, siete y diez días posdestete, se sa- crificaron cuatro cerdos y se tomaron para estudio muestras de intestino delgado, est%mago, hIgado, páncreas, corazón, pulmones, riñones y bazo. Las lesiones determinadas fueron congestión, edema, y hemorragia; se asignó un valor según el grado de presentación: ausente (0, leve (1, leve-moderada (2, moderada+severa 53<, severa 5=<. >os animales fueron pesados al destete y en el momento de sacrificio. Se encontraron diferencias (P < 0.01 en la aparición macroscópica de lesiones, peso de órganos, tem- peratura rectal y ganancia de peso. Los mayores valores se encontraron en el día uno posdestete y los menores en el día cinco; no obstante, para el día diez posdestete se observó una recuperación de las lesiones. La variable ocurrencia de diarreas presentó un comportamiento posdestete diferente y tendió a disminuir (P < 0.01.

  10. Trypanosoma (Herpetosoma rangeli Tejera, 1920: nota prévia sobre a histopatologia em camundongos infectados experimentalmente

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    Cecilia de Scorza

    1986-10-01

    Full Text Available Ratones machos (cepa NMRI de 3 y 5 gr, inoculados i.p. con 8 x 10(6 y 9 x 10(4 metatripo- mastigotes/gr cosechados de cultivo LIT de 12 días de repique de la cepa "Perro-82" de Trypanosoma rangeli fueron procesados, em determinados períodos postinoculación, para seccionar y teñir con hematoxilina-eosina y Giemsa-colofonio trozos de corozón, hígado, bazo, pulmones, fémur, riñon, intestino, estómago, cerebro, cerebelo, esternón y columna vertebral. Se detallan los resultados preliminares sobre la histopatologia provocada por el T. rangeli en los cinco primeros órganos citados. Los tejidos conjuntivos subcutáneo, periosteal, intersticial y peribronquial, así como las miocélulas del corazón fueron altamente parasitados por amastigotes y tripomastigotes. Se discuten las posibles razones de la disminución del parasitismo tisular cuando la parasitemia se encontró en sus niveles máximos, así como la escasa inflamación obtenida en los tejidos parasitados. Las observaciones de varios autores sobre el comportamiento del protozoario en humanos y en animales de laboratorio así como los resultados descritos en este trabajo, plantean la posibilidad de que determinadas cepas de T. rangeli, en condiciones particulares, podrían causar alteraciones patológicas en el mamífero.

  11. Valoración de parámetros clínicos y lesiones en órganos de cerdos durante el período posdestete

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    Julián Mejía-Medina

    2012-01-01

    Full Text Available El destete de cerdos está asociado con múltiples factores que generan respuestas inflamatorias tempranas en órganos internos y alta incidencia de diarreas. En el Centro de Investigación San Pablo de la Universidad Nacional de Colombia sede Medellín, se evaluaron los parámetros clínicos y las lesiones en órganos internos en dieciséis cerdos destetados a veintiún días de edad, que fueron alimentados durante diez días con una dieta a base de leche. Cada uno, cinco, siete y diez días posdestete, se sacrificaron cuatro cerdos y se tomaron para estudio muestras de intestino delgado, estómago, hígado, páncreas, corazón, pulmones, riñones y bazo. Las lesiones determinadas fueron congestión, edema, y hemorragia; se asignó un valor según el grado de presentación: ausente (0, leve (1, leve-moderada (2, moderada-severa (3, severa (4. Los animales fueron pesados al destete y en el momento de sacrificio. Se encontraron diferencias (P < 0.01 en la aparición macroscópica de lesiones, peso de órganos, temperatura rectal y ganancia de peso. Los mayores valores se encontraron en el día uno posdestete y los menores en el día cinco; no obstante, para el día diez posdestete se observó una recuperación de las lesiones. La variable ocurrencia de diarreas presentó un comportamiento posdestete diferente y tendió a disminuir (P < 0.01.

  12. Actividad hipotrigliceridémica de un extracto de rosa de Jamaica (Hibiscus sabdariffa L. al administrarse antes y durante las comidas

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    Rodrigo Castañeda

    2015-11-01

    Full Text Available a elevación de los lípidos sanguíneos se ha convertido en un riesgo común de enfermedades cardiovasculares,en especial en el caso del colesterol y triglicéridos, también a problemas pancreáticos, de la córnea, bazo e hígado.Hibiscus sabdariffa L., es una especie medicinal de la familia Malvaceae, su efecto sobre la reducción de los lípidos séricos se ha mencionado en varios estudios. El objetivo del presente estudio consistió en evaluar la actividad de un extracto acuoso de los cálices de H. sabdariffa, para reducir los lípidos séricos en dos grupos de individuos, con valores de triglicéridos mayores de 150 mg/dL, al recibir una dosis de 15 mg de antocianinas totales al día, dividida en tres veces, por un periodo de dos meses para establecer su influencia, dependiendo del momento de su administración, un grupo recibiéndola antes de la comida y otro durante la misma. El extracto de H. sabdariffa mostró un efecto hipotrigliceridémico significativo (p = 0.034, al finalizar el tratamiento, únicamente al administrar el extracto antes de las comidas. Al mismo tiempo, no se observó alteración en los niveles de colesterol total, colesterol contenido en las lipoproteínas de baja densidad y colesterol contenido en las proteínas de alta densidad en ninguno de los dos grupos evaluados. Los resultados sugieren que los extractos acuosos de H. sabdariffa podrían ser utilizados para ejercer una acción en los triglicéridos plasmáticos, dependiente del consumo de alimentos, y del momento de administración.

  13. Aspectos anatomopatológicos del linfosarcoma en el cerdo

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    A. RUIZ

    1997-01-01

    Full Text Available Se describen tres casos de linfosarcoma en cerdos de planteles de crianza industrial, dos de los cuales tenían un peso vivo de 60 kg y el tercer caso correspondió a una hembra reproductora de 280 kg de peso vivo. Los animales no presentaban signos ni síntomas clínicos específicos atribuibles a la enfermedad. A la necropsia se observó: aumento de tamaño de los ganglios linfáticos, bazo, hígado y placas de Peyer; presencia de un puntillado o nodulaciones blancas de tamaño variable en hígado y riñón. Histopatológicamente estos tejidos tenían infiltraciones de células de origen linfoide, y de aspecto de linfosarcoma.Three cases of lymphosarcoma in industrially-bred pigs are described, in which two of the pigs had a live weight of 60 kg, and the third, a reproductive female, had a live weight of 280 kg. The animals did not present any signs, nor specific clinical symptoms attributable to the disease. During the necropsy, an enlargement in the size of the lymphatic nodes, spleen, liver, and Peyer’s Plate was observed, as was the presence of white spots or nodules of various sizes on the liver and kidney. The histopathology carried out on the tissue revealed the presence of cells of lymphoid origin, and of a histological aspect of lymphosarcoma.

  14. Aborto viral equino. Descripción anatomopatológica de dos casos ocurridos en la VIII Región, Chile Histopathological aspects of two cases of equine viral abortion in the VIII Region, Chile

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    A. RUIZ

    1998-01-01

    Full Text Available Se describen dos casos de aborto viral equino, un feto abortado al final de la gestación y el otro nacido y muerto 24 horas después, provenientes de un predio que presentó otros 6 abortos más en la temporada de partos del año 1996. En la necropsia de ambos se observó ictericia, hemorragias oral y nasal, hemorragias de los linfonódulos, congestión general, pleuritis serofibrinosa, edema pulmonar, bronconeumonía catarral en los lóbulos apicales, ascitis, esplecnomegalia, necrosis del hígado y nefrosis. La histopatología y microscopía electrónica revelaron la existencia de cuerpos de inclusión intranucleares de tipo A de Cowdry en células epiteliales del pulmón, hepatocitos y macrófagos del bazo. Estos antecedentes son semejantes a lo descrito en aborto viral herpético o rinoneumonitis equina.Two cases of equine viral abortion are described: one foetus which was miscarried at the end of the pregnancy and the other which was born and died 24 hs later. Both cases came from a farm that had had 6 mare miscarriages during the 1996 birth period. The following lesions were observed in the necropsy: icterus, oral and nasal haemorrhages, lymphoid haemorrhages, general congestion, serophibrinous pleuritis, lung oedema, catarrhs bronchopneumonia at the apical lobes, ascitis, enlarged spleen, liver necrosis and nephrosis. Histopathology and electron microscopy indicated the presence of intranuclear inclusion bodies Cowdry type A in the epithelial cells of the lung, hepatocytes and macrophages of the spleen. All of the lesions are similar to those described in equine viral abortion or equine rhinopneumonitis

  15. Linfomatosis Bovina. Morfopatología en dos casos de campo

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    Joa, R.; Ancizar, J.; Betancourt, A.; Babaahmadi,

    2005-02-01

    Full Text Available La Linfomatosis ocurre exclusivamente en el tejido linfoide, de tal forma, que no está restringida en su origen a los ganglios linfáticos y el bazo, sino que surge también en los nódulos linfoides. En su diseminación puede afectar no solo al tejido linforreticular, sino a cualquier otro también (Ferrer, 1980. Se describe el cuadro lesional observado en dos hembras bovinas adultas, con edades de cinco y siete años, pertenecientes a una Unidad de Producción Lechera, las cuales fueron enviadas a sacrificio, por presentar anestro prolongado, linfoadenopatía en los ganglios precrurales y a la palpación rectal se le habían detectado formaciones nodulares en el útero. Las lesiones observadas se encontraban distribuidas en varios órganos y tejidos, con características similares a las descritas en la Leucosis Enzootica de los Bovinos.Lymphomatosis occure exclusivelly in lymphoid tissue, and it is not restrictelly to the lymphoid node and the spleen, also it may be initited in the isolated limphoid nodules. It may be diseminated to other tissue (ferrer, 1980. The postmorten fidings in two dayry cow is described. The age of the animals were five and seven years respectively, they belong from two dayry farm. They were send to slaugtherhause due to anestro, lymphoadenopaty of the precrural lymph node. Rectal palpation depicted nodular formation in the uterus. Several tissues and organ display lessions with similar caracteristics to Bovine Enzootic Leukosis.

  16. Obtención de anticuerpos monoclonales de ratón contra proteasa de cisteína 5 recombinante de Entamoeba histolytica

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    Juanita Trejos S.

    2012-08-01

    Full Text Available Objetivo. Obtener anticuerpos monoclonales de ratón contra la proteasas de cisteína 5 (EhCP5 de Entamoeba histolytica. Materiales y métodos. Se inmunizaron ratones BALB/c por vía intraperitoneal con adyuvante de Freund completo e incompleto con la proteína recombinante EhCP5 obtenida a partir del cultivo de E.coli DH5α trasfectada con el vector recombinante pJC45 que expresa dicha proteína. Se seleccionó el animal con mejor respuesta de anticuerpos. Al cual se le extrajo su bazo como fuente de linfocitos B, los cuales se fusionaron utilizando PEG con células de mieloma de ratón SP2-0/Ag14. Se procedió a selección de los hibridomas y a la evaluación de los sobrenadantes de las colonias que crecieron a los 7 días mediante ELISA. Los hibridomas con valores más altos de anticuerpos específicos contra la proteína EhCP5r se seleccionaron, y los clones obtenidos por diluciones limitantes fueron expandidos. Resultados. A partir de un clon secretor estable se purifico el anticuerpo monoclonal anti EhCP5r del isotipo IgG1 por cromatografía de afinidad con proteína G. Los clones fueron expandidos in vivo e in vitro. Con el anticuerpo purificado se diseñaron tres sistemas de captura para evaluar la aplicabilidad del anticuerpo monoclonal anti EhCP5r como método inmunodiagnóstico. Conclusiones. Se logro la producción de un anticuerpo monoclonal específico contra EhCP5r que permite diferenciar Entamoeba histolytica de Entamoeba dispar.

  17. Blood culture as a parameter of treatment effectiveness in experimental histoplasmosis of the hamster Hemocultivos como parametro de la eficacia del tratamiento de la histoplasmosis experimental en hamster

    Directory of Open Access Journals (Sweden)

    J. Finquelievich

    1995-04-01

    la fase levaduriforme del H. capsulatum equivalente a 4 x 10(7 células/ml. Los tratamientos comenzaron 1 semana después de la infección y se mantuvieron durante 3 semanas. Los compuestos azólicos, itraconazol, saperconazol y fluconazol se administraron por gastroclisis, una vez al día, a razón de 8mg/kg de peso; la anfotericina B fue aplicada por via intraperitoneal día por medio, en dosis de 6mg/kg. Se obtuvieron muestras de sangre para hemocultivo (1 ml a partir del 4º día post-infección y se sembraron placas de agar-miel de Sabouraud y agar infusión de cerebro y corazón. Los animales que sobrevivieron fueron autopsiados y se tomaron en consideración los siguientes parámetros: 1 tasa de muertes espontáneas al finalizar la experiencia; 2 resultados de los exámenes microscópicos de extendidos de hígado y bazo teñidos com Giemsa y; 3 UFC en cultivos de bazo. La anfotericina B fue la droga más eficaz, los hemocultivos de los animales tratados fueron negativos a partir del 20º dia de tratamiento, se negativizaron los cultivos de bazo y la totalidad de los hamsters sobrevivió. El menos eficaz fue el fluconazol que no modificó los resultados de los hemocultivos y los cultivos esplénicos y se registró el 42.8% de muertes espontáneas durante el estudio. Saperconazol e itraconazol exhibieron una eficacia similar, no se observaron muertes en los animales tratados y los hemocultivos se negativizaron a los 23 y 26 dias de tratamiento respectivamente. Los hemocultivos resultaron ser útiles como criterio para evaluar la eficacia terapéutica de las drogas antifúngicas en este modelo experimental de histoplasmosis.

  18. Gonadectomia pré-puberal em cães e gatos Prepubertal gonadectomy in dogs and cats

    Directory of Open Access Journals (Sweden)

    Fabiana Azevedo Voorwald

    2013-06-01

    Full Text Available A população de cães e gatos errantes é um problema grave de saúde pública e bem estar animal e a gonadectomia pré-puberal a partir de seis semanas de idade é a base para controle populacional efetivo. Os efeitos benéficos e maléficos são discutidos nesta revisão, auxiliando o médico veterinário a obter conhecimento e fundamentação científica para análise crítica do tema, propagação dessa prática e conscientização de proprietários.Stray dogs and cats is a serious problem to public health and animal welfare. Prepubertal gonadectomy from six weeks of age is a solution to effective pet overpopulation control. The benefits and adverse effects of this procedure are discussed in this paper, allowing the veterinarians to obtain knowledge and scientific basis to critical analysis to the topic, practice spread and owner awareness.

  19. Students' mental model development during historically contextualized inquiry: how the `Tectonic Plate' metaphor impeded the process

    Science.gov (United States)

    Dolphin, Glenn; Benoit, Wendy

    2016-01-01

    At present, quality earth science education in grade school is rare, increasing the importance of post-secondary courses. Observations of post-secondary geoscience indicate students often maintain errant ideas about the earth, even after direct instruction. This qualitative case study documents model-building activities of students as they experienced classroom instruction that braids history, inquiry, and model-based-learning within the context of earth dynamics. Transcripts of students' conversations, and their written work indicate students primarily employed model accretion to enhance their mental models. Instances of accretion were descriptive, pertaining to what their model consisted of, as opposed to how it explained the target phenomenon. Participants also conflated "continent" with "tectonic plate" and had difficulty attributing elastic properties - the mechanism for earthquakes - to rocks or "plates". We assert that the documented learning difficulties resulted from use of the metaphor "tectonic plate", reinforced by other everyday experiences and meanings. We suggest students need time with new models or concepts to develop strong descriptions before developing explanations. They need concrete experiences and explicit discussions concerning mapping those experiences to concepts. Lastly, because students often apply common meanings to scientific terms, we should not ask if they understand, but ask how they understand the concept.

  20. Gonzo Strategies of Deceit: An Interview with Joaquin Segura

    Directory of Open Access Journals (Sweden)

    Brett W. Schultz

    2011-06-01

    Full Text Available The interview that follows is a dialogue between artist and gallerist with the intent of unearthing the artist’s working strategies for a general public. Joaquin Segura is at once an anomaly in Mexico’s contemporary art scene at the same time as he is one of the most emblematic representatives of a larger shift toward a post-national identity among its youngest generation of artists. If Mexico looks increasingly like a foreclosed home burning to the ground, Segura could likely be the one walking away, charred matchstick between thumb and forefinger and shit-eating grin on his face. His corrosive attacks on institutions, ideologies, and power reflect a deep general distrust of authority, increasingly evident within the work of younger Mexican artists. It is perhaps most directly the result of President Calderon’s deeply unpopular war against the cartels but no doubt equally the product of decades upon decades of rampant corruption and errant policy within Mexico.

  1. Determination of Inter-leaf Translocated Free Glyphosate in Arabidopsis thaliana using Liquid Chromatography Tandem Mass Spectrometry (LCMS/MS) after Derivatization with Fluorenylmethyloxycarbonyl Chloride (FMOC-Cl)

    KAUST Repository

    Raji, Misjudeen

    2014-02-03

    Glyphosate is a broad-spectrum herbicide widely used for eliminating weeds in crop fields. Its mode of action is believed to be via translocation from the source to the sink tissues where it then interferes with the activities of 5-enol-pyruvylshikimate-3-phosphate synthase (EPSPS). In this study, the translocation of glyphosate in the leaves of Arabidopsis thaliana was investigated using an HPLC-MS/MS method following derivatization of the secondary amino group in the analyte using N-(9-fluorenylmethoxycarbonyloxy) chloride. To eliminate the errant precipitation that occurred when the reagent and the analyte are mixed, optimization of this method was required. The method linearity has a correlation coefficient higher than 0.99 over the concentration range of 0.005-2 μM. The limits of detection and quantitation were estimated to be 0.002 μM and 0.008 μM respectively. The repeatability of the method (as%R.S.D) ranged from 10% to 13%. The presented method was employed for the determination of free glyphosate in young untreated leaves of the specimen plants after treating a single leaf and allowing it to stand for 12 hours.

  2. A WSN-Based Intrusion Alarm System to Improve Safety in Road Work Zones

    Directory of Open Access Journals (Sweden)

    Jose Martin

    2016-01-01

    Full Text Available Road traffic accidents are one of the main causes of death and disability worldwide. Workers responsible for maintaining and repairing roadways are especially prone to suffer these events, given their exceptional exposure to traffic. Since these actuations usually coexist with regular traffic, an errant driver can easily intrude the work area and provoke a collision. Some authors have proposed mechanisms aimed at detecting breaches in the work zone perimeter and alerting workers, which are collectively called intrusion alarm systems. However, they have several limitations and have not yet fulfilled the necessities of these scenarios. In this paper, we propose a new intrusion alarm system based on a Wireless Sensor Network (WSN. Our system is comprised of two main elements: vehicle detectors that form a virtual barrier and detect perimeter breaches by means of an ultrasonic beam and individual warning devices that transmit alerts to the workers. All these elements have a wireless communication interface and form a network that covers the whole work area. This network is in charge of transmitting and routing the alarms and coordinates the behavior of the system. We have tested our solution under real conditions with satisfactory results.

  3. Branco sobre o branco: psicanálise, educação especial e inclusão escolar

    Directory of Open Access Journals (Sweden)

    Carla K. Vasques

    2009-04-01

    Full Text Available Na construção de processos inclusivos encontram-se obstáculos relativos aos supostos limites e possibilidades de escolarização das crianças com autismo e psicose infantil. Em conseqüência de sua estruturação psíquica singular, estes sujeitos apresentam comportamentos estereotipados, falas descontextualizadas, escritas e leituras presas na literalidade ou com sentido errante. Tais diferenças são, constantemente, percebidas como impedimentos para a inclusão escolar, justificando-se, assim, a ausência de atendimento ou o encaminhamento para espaços reeducativos, com vistas à adaptação comportamental. Este trabalho objetiva a construção de um novo olhar sobre esses sujeitos e suas possibilidades educacionais e subjetivas. Para tanto, apresenta o atendimento psicológico de uma criança, dos cinco aos onze anos, focando principalmente as relações entre clínica e escola. Como filtros de leitura têm-se a psicanálise freudo-lacaniana e as proposições da inclusão escolar. O estudo propõe-se a questionar interpretações mais estreitas, alargar perspectivas e flexibilizar os processos clínicos e educacionais. < Palavras-chave: Autismo e psicose infantil. Educação Especial. Inclusão Escolar.

  4. “Border Liners”. The Ship of Fools Tradition in Sixteenth-Century England

    Directory of Open Access Journals (Sweden)

    Zita Turi

    2010-07-01

    Full Text Available This paper investigates the effect of Sebastian Brandt’s The Ship of Fools in sixteenth-century England. My starting point is Michel Foucault’s Madness and Civilization and I attempt to trace the philological background and the way Brandt’s text determined early-Renaissance satire and later ’fool literature’ in England. My goal is to articulate the fact that the transgression of the ship does not manifest itself merely in the act of translation but also in the liminal position of the fool and the transgression among generic boundaries as well.En el ensayo estudio el efecto de la obra de Sebastian Brandt, titulada La nave de los locos, en la Inglaterra del siglo XVI. Mi estudio presenta el desarrollo del texto de Brandt en Inglaterra, partiendo del libro de Michael Foucault, La locura y la sinrazón, y destaca cómo el texto mencionado determina la sátira renacentista temprana y la literatura bufa de los finales del siglo. Espero que hasta el final de mi estudio pueda convencerles que el que el barco cruza la frontera no se encarna sólo en la existencia errante de los locos o en el acto de la traducción, sino se refiere a la interconexión de los géneros literarios también.

  5. Assessing Errors Inherent in OCT-Derived Macular Thickness Maps

    Directory of Open Access Journals (Sweden)

    Daniel Odell

    2011-01-01

    Full Text Available SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness maps. Forty-three patients with various retinal pathologies and 113 normal subjects were imaged using Cirrus HD-OCT. Reduced B-scan density was associated with increased interpolation error in ETDRS macular thickness plots. Correcting for individual differences in axial length revealed modest errors in retinal thickness maps, while more pronounced errors were observed when the ETDRS plot was not positioned at the center of the fovea (which can occur as a result of errant fixation. Cumulative error can exceed hundreds of microns, even under “ideal observer” conditions. This preventable error is particularly relevant when attempting to compare macular thickness maps to normative databases or measuring the area or volume of retinal features.

  6. Damage-Tolerant Fan Casings for Jet Engines

    Science.gov (United States)

    2006-01-01

    All turbofan engines work on the same principle. A large fan at the front of the engine draws air in. A portion of the air enters the compressor, but a greater portion passes on the outside of the engine this is called bypass air. The air that enters the compressor then passes through several stages of rotating fan blades that compress the air more, and then it passes into the combustor. In the combustor, fuel is injected into the airstream, and the fuel-air mixture is ignited. The hot gasses produced expand rapidly to the rear, and the engine reacts by moving forward. If there is a flaw in the system, such as an unexpected obstruction, the fan blade can break, spin off, and harm other engine components. Fan casings, therefore, need to be strong enough to contain errant blades and damage-tolerant to withstand the punishment of a loose blade-turned-projectile. NASA has spearheaded research into improving jet engine fan casings, ultimately discovering a cost-effective approach to manufacturing damage-tolerant fan cases that also boast significant weight reduction. In an aircraft, weight reduction translates directly into fuel burn savings, increased payload, and greater aircraft range. This technology increases safety and structural integrity; is an attractive, viable option for engine manufacturers, because of the low-cost manufacturing; and it is a practical alternative for customers, as it has the added cost saving benefits of the weight reduction.

  7. Galaxy Zoo CANDELS Data Release I: Morphologies of ~50,000 Galaxies With z ≤ 3 in Deep Hubble Legacy Fields

    Science.gov (United States)

    Simmons, Brooke; Lintott, Chris; Masters, Karen; Willett, Kyle; Kartaltepe, Jeyhan S.; Closson Ferguson, Henry; Faber, Sandra M.; Galaxy Zoo Team, CANDELS Team

    2016-01-01

    We present quantified visual morphologies of approximately 48,000 galaxies in rest-frame optical to z ~ 3, using galaxies observed in three Hubble Space Telescope legacy fields by the Cosmic And Near-infrared Deep Extragalactic Legacy Survey (CANDELS) and classified by participants in the Galaxy Zoo project. Each galaxy received an average of 43 independent classifications, which we combine into detailed morphological information on galaxy features such as clumpiness, bar instabilities, spiral structure, and merger and tidal signatures. We apply a consensus-based classifier weighting method that preserves classifier independence while effectively down-weighting significantly errant classifications. Comparing the Galaxy Zoo classifications to previous human and machine classifications of the same galaxies shows very good agreement; in some cases the high number of independent classifications provided by Galaxy Zoo provides an advantage in selecting galaxies with a particular morphological profile, while in others the combination of Galaxy Zoo with other classifications is a more promising approach than using any one method alone. We combine the Galaxy Zoo classifications of "smooth" galaxies with parametric morphologies to select a sample of featureless disks at 1 ≤ z ≤ 2, which may represent a dynamically warmer progenitor population to the settled disk galaxies seen at later epochs.

  8. Le Clézio et l'immigration : le tragique du réel

    Directory of Open Access Journals (Sweden)

    Bernadette Mimoso-Ruiz

    2011-11-01

    Full Text Available Nous retiendrons trois œuvres représentatives de Le Clézio qui appartiennent à des registres différents : Désert, en lien direct avec la colonisation et ses conséquences, la nouvelle « Le Passeur » évocatrice du drame des immigrés clandestins et Etoile errante, fondée sur l’émigration croisée des Juifs et des Palestiniens. Chacune de ces œuvres tisse des liens entre réel et fiction, empruntant un cadre ou une situation à des données tangibles perceptibles dans le temps et dans l’espace, comme autant de repères reconnaissables. Le réel de la réalité, se sublime par les mots qui l’expriment, dans une poétique des affects soulevant le voile pour accéder à une vérité. Ce réel crédible, représenté par les jalons spatiotemporels, porte la voix de l’insurrection contre les injustices qui privent des être humains de leur dignité, les confinent dans le silence et les dépossèdent de leur identité.

  9. Financial Crisis, Financial Firms… And Financial Feminism? The Rise of ‘Transnational Business Feminism’ and the Necessity of Marxist-Feminist IPE

    Directory of Open Access Journals (Sweden)

    Adrienne Roberts

    2012-10-01

    Full Text Available This paper documents the rise of a politico-economic project of what I have termed ‘transnational business feminism’, focused on the need to promote women’s empowerment, particularly in the wake of the most recent global financial crisis. Here, liberal feminists have joined with states, funding institutions, NGOs and MNCs in constructing women as ‘untapped resources’ capable of delivering a high return on (Western investment. This project has also generated new knowledges regarding both gender and finance, as the ‘excesses’ that led to the 2008 crisis have been linked to an errant masculinity that can be adjusted by incorporating women (and feminine values into the finance realm. However, a feminist historical materialist reading of this project reveals that gender is used as part of a narrative that seeks to naturalize and depoliticize capitalist crises. Gender also becomes the basis for the re-embedding of capitalist relations that reproduce the exploitation of men and women while creating new markets and sources of profit for capital. While transnational business feminism is rooted in a particular version of Western liberal feminism that seeks empowerment via integration into the market economy, this paper argues that the contemporary moment offers an opportunity for a renewed emphasis on feminist scholarship that is firmly wedded to anti-capitalism, as well as a Marxism that takes gender seriously.

  10. Reactor protection system with automatic self-testing and diagnostic

    International Nuclear Information System (INIS)

    A reactor protection system is disclosed having four divisions, with quad redundant sensors for each scram parameter providing input to four independent microprocessor-based electronic chassis. Each electronic chassis acquires the scram parameter data from its own sensor, digitizes the information, and then transmits the sensor reading to the other three electronic chassis via optical fibers. To increase system availability and reduce false scrams, the reactor protection system employs two levels of voting on a need for reactor scram. The electronic chassis perform software divisional data processing, vote 2/3 with spare based upon information from all four sensors, and send the divisional scram signals to the hardware logic panel, which performs a 2/4 division vote on whether or not to initiate a reactor scram. Each chassis makes a divisional scram decision based on data from all sensors. Automatic detection and discrimination against failed sensors allows the reactor protection system to automatically enter a known state when sensor failures occur. Cross communication of sensor readings allows comparison of four theoretically ''identical'' values. This permits identification of sensor errors such as drift or malfunction. A diagnostic request for service is issued for errant sensor data. Automated self test and diagnostic monitoring, sensor input through output relay logic, virtually eliminate the need for manual surveillance testing. This provides an ability for each division to cross-check all divisions and to sense failures of the hardware logic. 16 figs

  11. Construindo idéias sobre a juventude envolvida com a criminalidade violenta

    Directory of Open Access Journals (Sweden)

    Andréa Máris Campos Guerra

    2010-08-01

    Full Text Available Revisando a bibliografia atual sobre o tema da violência urbana entre jovens, verificamos que o contexto nacional de convivência com a desigualdade social acirra a violência entre jovens moradores de aglomerados urbanos. Essa violência é potencializada pela experiência da adolescência – transição que marca a perda do corpo e dos pais infantis, bem como o encontro com o outro sexo –, bem como pela experiência errante de desfiliação histórica, que caracteriza a subjetividade na contemporaneidade. Dessa maneira, supomos que, diante da precariedade de significação social da cultura contemporânea, o jovem tenta encontrar novas formas de estabelecer-se no laço social, buscando alguma amarra coletiva pela via do crime. Assim, a entrada numa gangue ou num circuito criminoso pode oferecer, diante dessa carência simbólica, uma promessa de sentido social e uma ilusão afetiva, favorecendo a violência.

  12. "Mind your p's and q's": or the peregrinations of an apostrophe in 17th Century English

    CERN Document Server

    Piton, Odile

    2010-01-01

    If the use of the apostrophe in contemporary English often marks the Saxon genitive, it may also indicate the omission of one or more let-ters. Some writers (wrongly?) use it to mark the plural in symbols or abbreviations, visual-ised thanks to the isolation of the morpheme "s". This punctuation mark was imported from the Continent in the 16th century. During the 19th century its use was standardised. However the rules of its usage still seem problematic to many, including literate speakers of English. "All too often, the apostrophe is misplaced", or "errant apostrophes are springing up every-where" is a complaint that Internet users fre-quently come across when visiting grammar websites. Many of them detail its various uses and misuses, and attempt to correct the most common mistakes about it, especially its mis-use in the plural, called greengrocers' apostro-phes and humorously misspelled "greengro-cers apostrophe's". While studying English travel accounts published in the seventeenth century, we noticed th...

  13. Analysis of developed transition road safety barrier systems.

    Science.gov (United States)

    Soltani, Mehrtash; Moghaddam, Taher Baghaee; Karim, Mohamed Rehan; Sulong, N H Ramli

    2013-10-01

    Road safety barriers protect vehicles from roadside hazards by redirecting errant vehicles in a safe manner as well as providing high levels of safety during and after impact. This paper focused on transition safety barrier systems which were located at the point of attachment between a bridge and roadside barriers. The aim of this study was to provide an overview of the behavior of transition systems located at upstream bridge rail with different designs and performance levels. Design factors such as occupant risk and vehicle trajectory for different systems were collected and compared. To achieve this aim a comprehensive database was developed using previous studies. The comparison showed that Test 3-21, which is conducted by impacting a pickup truck with speed of 100 km/h and angle of 25° to transition system, was the most severe test. Occupant impact velocity and ridedown acceleration for heavy vehicles were lower than the amounts for passenger cars and pickup trucks, and in most cases higher occupant lateral impact ridedown acceleration was observed on vehicles subjected to higher levels of damage. The best transition system was selected to give optimum performance which reduced occupant risk factors using the similar crashes in accordance with Test 3-21. PMID:23820073

  14. Don Quijote, el escribidor y el escritor

    Directory of Open Access Journals (Sweden)

    Giovanna Pollarolo

    2010-06-01

    Full Text Available In his diverse critical studies, Mario Vargas Llosa has shown particular interest in reflecting on Miguel de Cervantes’s novelistic theory in accordance with his own concerns as a scholar and novelist. Suffice it to read the essay “Una novela para el siglo XXI” that he wrote in 2005 as an introduction to the edition of Don Quijote prepared to celebrate the IV Centenario, to make sure that Vargas Llosa “reads” Cervantes in accordance with his own reflections on the theory of the novel, fanaticism or the “insanity” of the characters, the fiction and its relationship with “reality”, the narrative voices or the problem of the narrator. But the Cervantes – Vargas Llosa relationship goes beyond the theoretical level or reflective and is manifested in his own novelistic creation such as ocurrs, specifically, in La tía Julia y el escribidor. In that sense, the main goal of this study is to analyze the “dialogue” that is set between La tía Julia y el escribidor and the Quijotefrom the point of view of the “insanity” of Pedro Camacho, the writer of radio soap operas created by Vargas Llosa, and their similarities with that of the knight-errant.

  15. Design features and performance of the LAMPF high-intensity beam area

    International Nuclear Information System (INIS)

    LAMPF is a multi-purpose high-intensity meson factory capable of producing a 1 mA beam of 800-MeV protons. The three target cells and the beam stop facilities in the high intensity area have many special design features that are required for operation in the presence of high heat loads and intense radiation fields where accessibility is extremely limited. Reliable targets, beam windows, beam stops, beam transport and diagnostic components, vacuum enclosures, and auxiliary systems have been developed. Sophisticated remote-handling systems are employed for maintenance. Complex protection systems have been developed to guard against damage caused by errant beam. Beam availability approaching 90% has been achieved at currents of 600 to 700 μA. A new facility for direct proton and neutron radiation effects studies will be installed in 1985. The new facility will provide an integrated spallation neutron flux of up to 5 x 1017 m-2s-1 and will anable proton irradiation studies in the primary beam

  16. High power laser beam delivery monitoring for laser safety

    Science.gov (United States)

    Corder, D. A.; Evans, D. R.; Tyrer, J. R.; Freeland, C. M.; Myler, J. K.

    1997-07-01

    The output of high power lasers used for material processing presents extreme radiation hazards. In normal operation this hazard is removed by the use of local shielding to prevent accidental exposure and system design to ensure efficient coupling of radiation into the workpiece. Faults in laser beam delivery or utilization can give rise to hazardous levels of laser radiation. A passive hazard control strategy requires that the laser system be enclosed such that the full laser power cannot burn through the housing under fault conditions. Usually this approach is too restrictive. Instead, active control strategies can be used in which a fault condition is detected and the laser cut off. This reduces the requirements for protective housing. In this work a distinction is drawn between reactive and proactive strategies. Reactive strategies rely on detecting the effects of an errant laser beam, whereas proactive strategies can anticipate as well as detect fault conditions. This can avoid the need for a hazardous situation to exist. A proactive strategy in which the laser beam is sampled at the final turning mirror is described in this work. Two control systems have been demonstrated; the first checks that beam power is within preset limits, the second monitors incoming beam power and position, and the radiation reflected back from the cutting head. In addition to their safety functions the accurate monitoring of power provides an additional benefit to the laser user.

  17. The Duchess and Altisidora: Two Enemies of Dulcinea

    Directory of Open Access Journals (Sweden)

    Amalia Iriarte

    2015-11-01

    Full Text Available Don Quixote creates Dulcinea of El Toboso, the beloved of the knight-errant, out of his recollections of Aldonza Lorenzo. The character of Dulci­nea is very different from the peasant woman who inspired her creation, to the point that the latter is entirely effaced, while the imaginary Dulcinea, as she has taken possession of don Quixote’s inner world, becomes stronger and plays an increa­singly important role in the novel, exerting influence on the development of events. This will be more evident in the second part of the novel, where two women at the duke’s court, the duchess herself and Altisidora, take on the task of unmasking the nonexistence of Dulcinea, and induce don Quixote to fall in love with a real woman, a role assumed by Altisidora. In this essay, I argue that the more these real women question Dulci­nea, the stronger will be don Quixote’s feelings for his imaginary beloved. This process takes place within one of the central conflicts of Cervantes’ novel: the struggle between the creatures of the imagination and those we accept as real.

  18. Nanoengineering a single-molecule mechanical switch using DNA self-assembly

    International Nuclear Information System (INIS)

    The ability to manipulate and observe single biological molecules has led to both fundamental scientific discoveries and new methods in nanoscale engineering. A common challenge in many single-molecule experiments is reliably linking molecules to surfaces, and identifying their interactions. We have met this challenge by nanoengineering a novel DNA-based linker that behaves as a force-activated switch, providing a molecular signature that can eliminate errant data arising from non-specific and multiple interactions. By integrating a receptor and ligand into a single piece of DNA using DNA self-assembly, a single tether can be positively identified by force–extension behavior, and receptor–ligand unbinding easily identified by a sudden increase in tether length. Additionally, under proper conditions the exact same pair of molecules can be repeatedly bound and unbound. Our approach is simple, versatile and modular, and can be easily implemented using standard commercial reagents and laboratory equipment. In addition to improving the reliability and accuracy of force measurements, this single-molecule mechanical switch paves the way for high-throughput serial measurements, single-molecule on-rate studies, and investigations of population heterogeneity.

  19. Nanoengineering a single-molecule mechanical switch using DNA self-assembly

    Science.gov (United States)

    Halvorsen, Ken; Schaak, Diane; Wong, Wesley P.

    2011-12-01

    The ability to manipulate and observe single biological molecules has led to both fundamental scientific discoveries and new methods in nanoscale engineering. A common challenge in many single-molecule experiments is reliably linking molecules to surfaces, and identifying their interactions. We have met this challenge by nanoengineering a novel DNA-based linker that behaves as a force-activated switch, providing a molecular signature that can eliminate errant data arising from non-specific and multiple interactions. By integrating a receptor and ligand into a single piece of DNA using DNA self-assembly, a single tether can be positively identified by force-extension behavior, and receptor-ligand unbinding easily identified by a sudden increase in tether length. Additionally, under proper conditions the exact same pair of molecules can be repeatedly bound and unbound. Our approach is simple, versatile and modular, and can be easily implemented using standard commercial reagents and laboratory equipment. In addition to improving the reliability and accuracy of force measurements, this single-molecule mechanical switch paves the way for high-throughput serial measurements, single-molecule on-rate studies, and investigations of population heterogeneity.

  20. Coordinating perception and action with an underwater robot in a shallow water environment

    Science.gov (United States)

    Bonasso, R. P.

    1992-04-01

    It is usually difficult to use underwater robots for mapping, reconnaissance, and mine-clearing tasks in shallow water (10 to 80 foot depth) ocean environments. The shallow water environment is characterized by strong, intermittent wave surge which requires robot behaviors that are capable of riding out the surge and then repositioning the platform and re- acquiring the objects being sensed. The shallow water area is also characterized by water that is murky, making optical sensors useless for long range search, and which produces multiple paths for sonar returns, giving errant range readings. Teleoperation from a remote surface platform is not effective due to the rapid changes in the environment. A more promising approach would place reactive intelligence on-board the robot. This paper describes such an approach which uses high frequency acoustic and vision sensing and a situated reasoning software architecture to provide task-achieving capability to an underwater robot in a shallow water environment. The approach is demonstrated in the context of a shallow water marking task wherein a robot must locate and navigate to a moored object in shallow water depths, attach a buoyant marker, and then return to a destination location. The approach seeks to integrate selective perception with robust transit and hovering behaviors to overcome the natural problems associated with shallow water environments.

  1. Lecturas de un Clown

    Directory of Open Access Journals (Sweden)

    Eric De Bont

    2012-06-01

    Full Text Available Quedé realmente sorprendido por la invitación de Álabe para escribir un relato sobre la influencia de la lectura en mi vida. A decir verdad, la invitación me vino un poco mal, entre las presentaciones finales de la escuela y la preparación de mi viaje de dos meses a Cerdeña y la Toscana.Yo, como holandés errante, tendría que escribir algo sobre un sinfín de escritores y libros de literatura holandesa. Por eso me gustaría escribir este texto como un documento personal, de qué manera la literatura ha sido, y sigue siendo, importante en mi propia búsqueda hacia mi propia identidad como ser humano, hacia mi esencia, por qué mi alma ha creado este cuerpo en este momento para conocer nuevas experiencias aquí en la tierra.

  2. Nietzsche e Dom Quixote: diálogos entre ‘loucos’ = Nietzsche and Don Quixote: dialogues between ‘mad’

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    Helder Felix Pereira Souza

    2012-01-01

    Full Text Available Partindo das ideias do pensador Nietzsche e caminhando por diversas obras escritas pelo pensador, selecionaram-se algumas passagens para projetar olhares sobre a obra literária Dom Quixote de la Mancha, do espanhol Miguel de Cervantes, sobretudo, em relação à personagem Dom Quixote. Possibilita-se, assim, apresentar outras perspectivas sobre essas duas peculiares figuras: o pensador Nietzsche e o cavaleiro andante Dom Quixote. Destaca-se, por fim, a importância deste entrecruzamento para estimular possibilidades imaginativas-criativas para se pensar a filosofia e a arte mediante a exceção, a loucura e o devir.Building on the ideas of philosopher Nietzsche and walking on several works written by the thinker, some passages have been selected to design looks on the literary work Don Quixote de la Mancha, of Spanish, Miguel de Cervantes, especially in relation to the character Don Quixote. Thus making it possible to present other perspectives on these two unique figures: the thinker Nietzsche and the knight-errant Don Quixote. Emphasizing, finally, the importance of this intersection to stimulate possibilities imaginative-creative of thinking the philosophy and art through the exception, of madness and of devir.

  3. Cervantes y la monarquia absolutista

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    Ludovik Osterc

    1999-12-01

    Full Text Available La vida de Cervantes es un rosario de contratiempos, adversidades, vejámenes y sufrimientos. Miguel conoció la pobreza desde la cuna y la vida errante hasta la muerte. Apenas tocado por el hálito del prestigio literario en su juventud, habiendo escrito algunas poesías con motivo del fallecimiento de Ia tercera esposa del rey Felipe II, Isabel de Valois, por encargo de su maestro López de Hoyos quien lo Ilamó »mi caro y amado discípulo«, se vio envuelto en un duelo con un tal Antonio de Sigura, andante en la Corte, al cual había inferido varias heridas, según parece, por razones de honor. Este desafortunado suceso tuvo por consecuencia una cédula real que lo condenaba en rebeldía a que »eon vergüenza pública le fuese cortada Ia mano derecha- la mano de la pluma y la espada! -y a diez anos de destierro.« Pero, como no hay mal que por bien no venga, Cervantes huyó a Italia cuyo arte y cultura renacentistas lo fascinaron, salvando así su integridad física del bárbara fallo. En Roma entro en el servicio del cardenal Acquaviva en calida.d decamarero.

  4. Was disease involved in the decimation of Guam's avifauna?

    Science.gov (United States)

    Savidge, Julie A.; Sileo, Louis; Siegfried, L.M.

    1992-01-01

    Between 1982 and 1986, 402 (290 live, 112 dead) exotic, migrant or native resident birds on Guam were surveyed for disease-causing agents to determine the role of disease in the decline of native forest bird populations on Guam. Traumatic injury, primarily from collisions with motor vehicles and predation, was the most prevalent (46%) cause of death. Thirty-eight percent of the carcasses examined were in poor body condition largely as a result of inadequate nutrition in captive native birds and poultry and adipose exhaustion in errant migrants. A variety of commensal or opportunistic bacteria, including Salmonella spp., were cultured from 220 birds, and nothing remarkable was found in 15 fecal samples. Lastly, no haematozoans, the suspected cause for the decline of the Hawaiian avifauna, were observed in blood slides examined from 260 birds. Based on the results of the survey and other lines of evidence presented in the discussion, we concluded there were no data implicating disease in the decline of Guam's avifauna.

  5. Raised Relief Mars Globe Brings the Red Planet Closer

    Science.gov (United States)

    2006-01-01

    The Mars Globe 20x is the first digitally produced raised relief globe to be sold at retail establishments. The rises and dips of the Martian landscape have been multiplied by 20 to make the shapes more noticeable to human touch and sight. They make this globe, with its over 1 million elevation points, a visually stunning introduction to the planet. Spectrum 3D used the NASA digital land elevation data to aim lasers that then shaped and defined the master globe s surface. Subsequent copies were then made by creating a master globe mold. The molded copies are hand finished by workers who remove errant edges or lines that may appear on the raw globes and then paint the surfaces. The result is a globe that measures in at 18 inches in diameter, roughly 1:15,729,473 scale of the actual planet. The exaggerated raised relief is like having a 3-D digital microscope for planetary shapes. This makes the landmarks easier to learn and understand, as it provides easy visuals for orientation. People have a natural propensity for understanding 3-D shapes more easily than numbers or words. The 3-D globes appeal to both the kinetic and visual learning aspects of the brain, making it easy for people to readily memorize the landmarks and to make a mental model that they will remember for a long time.

  6. Infarto esplénico secundario a pancreatitis aguda Splenic infarction secondary to acute pancreatitis

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    J. J. Arenal Vera

    2008-05-01

    Full Text Available Fundamento y objetivo: la estrecha relación anatómica del páncreas con los vasos esplénicos y el bazo es responsable de complicaciones esplénicas en el curso de la pancreatitis aguda. El objetivo es presentar dos casos clínicos de pancreatitis aguda grave que sufrieron infarto esplénico como complicación de la enfermedad pancreática. Pacientes, participantes: en un periodo de tres meses, dos pacientes fueron diagnosticados de infarto esplénico secundario a pancreatitis aguda. En ambos casos el diagnóstico y seguimiento evolutivo del infarto esplénico se hizo a través de tomografía axial computerizada. Resultados: en el primer paciente, las imágenes muestran de forma inequívoca la afectación de la arteria esplénica por el proceso inflamatorio pancreático. En el segundo, no se pudo demostrar afectación de los vasos esplénicos, por lo que la única posible explicación etiológica es un incremento de coagulabilidad intravascular. Conclusiones: sería recomendable añadir las complicaciones esplénicas al conjunto de complicaciones graves extrapancreáticas de la pancreatitis aguda. La tomografía axial computerizada es de gran utilidad para la detección y seguimiento de las complicaciones esplénicas de la pancreatitis aguda.Background and objective: the close anatomic relationship of the pancreas with the splenic vessels and the spleen is responsible for splenic complications in the course of acute pancreatitis. Our objective was to report two cases of severe acute pancreatitis complicated by splenic infarction. Patients: in a three-month period of time two patients were diagnosed with splenic infarction secondary to acute pancreatitis. In both cases splenic infarction diagnosis and follow-up were carried out using computed tomography. Results: in the first case images clearly showed a narrowing of the splenic artery due to the inflammatory pancreatic condition. In the second case no involvement of the splenic vessels could

  7. Spirotetramat induce cambios histológicos y bioquímicos en rata Wistar

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    M. Falcón-Etchechury

    2013-01-01

    Full Text Available Spirotetramat, comercialmente conocido como Movento®, es derivado del ácido tetrámico, empleado en el cultivo de la vid y de algunos vegetales para el control de parásitos chupadores. Los estudios toxicológicos in vivo solo publican una descripción general de su metabolismo. El objetivo de este estudio fue conocer los cambios en el comportamiento, en indicadores bioquímicos séricos e histológicos en ratas Wistar macho. Se realizó los siguientes tratamientos: a intoxicación aguda con Spirotetramat -1 (BY108330, 15.3% vía oral con 1⁄4 DL (625 mg kg y 1⁄2 DL (1250 50 50-1 mg kg , y b control. Se obtuvieron muestras de sangre mediante punción cardíaca los días 1, 3 y 7; las muestras se evaluaron por cambios en indicadores bioquímicos (triglicéridos, colesterol, albúmina, proteína total, actividad de transaminasas, urea y creatinina, y cambios histológicos en hígado, riñón y páncreas. Se presentó la muerte en el 35% de los animales tratados. Se observaron signos de toxicidad como: salivación, ataxia, convulsiones, sangrado nasal y diarrea. El peso corporal y el peso relativo del hígado en promedio fueron constantes, sin diferencias entre tratamientos, ni entre días. El perfil lipídico y las transaminasas presentaron una tendencia al incremento en relación al control. En la evaluación histológica los hepatocitos mostraron degeneración balonoide en el 25% (8 de 32 y colestasis en el 72% (23 de 32 de las ratas intoxicadas, sin embargo en bazo y riñón no se observaron cambios visibles en relación al control.

  8. Aspergilosis: una patología a considerar Aspergillosis: a phatology to be considered

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    Héctor Guillermo Oxilia

    2008-03-01

    Full Text Available La aspergilosis pulmonar es una infección micótica causada por el Aspergillus fumigatus, saprófito del esputo humano normal. Se estudiaron cinco casos de pacientes con aspergilosis, cuatro de ellos adultos, tres del sexo femenino y uno masculino, todos de presentación no invasiva, y uno, pediátrico, sexo masculino, del tipo invasiva. Fueron estudiados con radiología convencional, tomografía computada (TC helicoidal, TC multislice y video cápsula endoscópica. Afecta 3:1 a los hombres en relación con las mujeres. Hay tres formas de presentación: a invasiva: en los pacientes neutropénicos, donde predomina la afectación pulmonar, con diseminación a cerebro, corazón, riñón, tracto gastrointestinal, hígado, tiroides y bazo; tiene mal pronóstico y la mortalidad es muy elevada; b semiinvasiva: compromete fundamentalmente a pacientes con patología pulmonar preexistente; c no invasiva: afecta cavidades preexistentes, cavernas TBC ( tuberculosis o quistes, donde coloniza el hongo, y se denomina aspergiloma o micetoma.Pulmonary aspergillosis is a mycotic infection caused by the Aspergillus fumigatus, saprophyte of the normal human sputum. Five patients with non invasive aspergillosis were studied, of whom 4 were adults (3 women, 1 man and one, pediatric, with invasive aspergillosis. All of them were studied by conventional X-ray, spiral CT, multislice CT and video capsule endoscopy. The presentation is predominant among men (3 to 1. There are three forms of presentation: a invasive: in neutropenic patients it prevails the lung affectation; the brain, heart, kidney gastrointestinal tract, liver, thyroid and spleen spreading has a bad prognosis and mortality rate is very high; b semiinvasive: it mainly compromises patients with pre-existing pulmonary pathology; c non invasive: affects pre-existing cavities, TBC caverns or cysts where the fungus establishes; it is called aspergilloma or mycetoma.

  9. LPL-01 utilizando vías diferentes de exposición

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    A Mancebo

    2005-01-01

    Full Text Available Los nemátodos parásitos de las plantas, conocidos como plagas agrícolas desde el siglo XIX, causan un 9% de pérdidas de cultivos en los países desarrollados y un 14% en los países en desarrollo. El Paecilomyces lilacinus es un hongo parásito que ataca formas sedentarias de los nemátodos, como los huevos. Su valoración como agente microbiano de control debe incluir una evaluación de su virulencia hacia organismos no-diana, tomando en consideración las vías posibles de exposición de los humanos. Para evaluar la patogenicidad de la cepa LPL-01 del P. lilacinus en ratas, se administró por las vías oral, pulmonar e intravenosa. Las observaciones clínicas fueron diarias, y se evaluó el comportamiento del peso corporal. Se estimó el aclaramiento mediante recolección de las heces fecales y análisis de muestras de los pulmones y de la sangre, según la vía de administración, y se evaluó la infectividad mediante toma de muestras de órganos de animales inoculados sacrificados a intervalos. Durante estos sacrificios, y al final de los ensayos, se realizó la necropsia de los animales. No ocurrieron mortalidades, ni evidencias de patogenicidad relacionada con el tratamiento en los ensayos oral y pulmonar, no provocando el hongo una infestación significativa. Por vía endovenosa, el microorganismo provocó alteraciones anátomo-patológicas en hígado y bazo, coincidiendo con el período de máxima infestación. Se concluyó que la cepa LPL-01 del P. lilacinus, a las dosis evaluadas, no es patogénica por las vías oral y pulmonar, siendo levemente patogénica por vía endovenosa

  10. Valoración de parámetros clínicos y lesiones en órganos de cerdos durante el período posdestete Evaluation of clinical parameters and lesions in pig organs during post-weaning period

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    Julián Mejía-Medina

    2012-01-01

    Full Text Available El destete de cerdos está asociado con múltiples factores que generan respuestas inflamatorias tempranas en órganos internos y alta incidencia de diarreas. En el Centro de Investigación San Pablo de la Universidad Nacional de Colombia sede Medellín, se evaluaron los parámetros clínicos y las lesiones en órganos internos en dieciséis cerdos destetados a veintiún días de edad, que fueron alimentados durante diez días con una dieta a base de leche. Cada uno, cinco, siete y diez días posdestete, se sacrificaron cuatro cerdos y se tomaron para estudio muestras de intestino delgado, estómago, hígado, páncreas, corazón, pulmones, riñones y bazo. Las lesiones determinadas fueron congestión, edema, y hemorragia; se asignó un valor según el grado de presentación: ausente (0, leve (1, leve-moderada (2, moderada-severa (3, severa (4. Los animales fueron pesados al destete y en el momento de sacrificio. Se encontraron diferencias (P To evaluate the effect of early weaning on clinical parameters, development and occurrence of lesions in organs of systemic importance, and weight gain in pigs evaluations were carried out. The experiment was conducted in the San Pablo Production Research Center of the Universidad Nacional de Colombia (Medellín. We used 16 weaned pigs at 21 days of age. The animals were fed for 10 days with a basal diet (milk. Four pigs were slaughtered on days 1, 5, 7 and 10 post-weaning and samples of intestine, stomach, liver, pancreas, heart, lungs, kidneys and spleen were extracted. Congestion, edema, and hemorrhage were the lesions determined; a value according to the degree of presentation was assigned: absent (0, mild (1, mild-moderate (2, moderate-severe (3, severe (4. The animals were weighed on weaning day, and the day of slaughter. Statistical difference (P < 0.01 was found in macroscopic appearance of lesions, organ weight, rectal temperature, and weight gain. On the first day of post-weaning the highest values

  11. Influencia del hierro de reserva y sérico en la anemia del ternero neonato - - Influence of store and seric iron in neonatal calf anemia.

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    Figueredo, J.M

    2010-04-01

    Full Text Available ResumenCon el objetivo de determinar los minerales de reserva que intervienenen la hematopoyesis, fueron estudiados 20 terneros recién nacidosdivididos en dos grupos experimentales, el grupo 1 (n=12 loconstituyeron terneros anémicos y el grupo 2, (n=8 terneros que nopresentaron anemia. A todos se les extrajo sangre para estudioshemáticos (serie roja, bioquímicos (proteinograma y de mineralescobre y hierro sérico (capacidad de unión del hierro sérico, % desaturación de la transferrina, capacidad total y capacidad latente deunión del hierro. Los terneros fueron sacrificados para estudios de los niveles de hierro y cobre en fragmentos de hígado, bazo, cerebro ymúsculos. Los resultados pusieron de manifiesto la presencia deanemia de tipo microcítica hipocrómica con disminución del hierrosérico, disminución del % de saturación de la transferrina y aumentode la capacidad latente de unión del hierro. En hígado y cerebro seencontraron disminuidas la concentración de hierro. El proteinogramano presentó diferencia entre ambos grupos.SummaryIn order to determine the mineral reserves that are involved inhematopoiesis 20 newborn calves were stood divided in twoexperimental groups, 12 anemic calves in group 1 and 8 normal calvesin group 2, In all animals were take blood for hematic stood (redseries, biochemistry (proteinogram, cooper and iron minerals(capacity of iron union, saturation of transferrin and total an latentcapacity. The calves were autopsied and the levels of cooper and ironwere stood in liver, spleen, brain, and muscle The result showed microcitic and hipocromic anemic presence, with low iron, % of transferrin saturation and an increase of iron union were found in anemic calves. In liver and brain the iron concentration were lower and in the proteinogram the result were similar in both group.

  12. Paracoccidioidomicosis: Manifestaciones orales e implicaciones sistémicas Paracoccidioidomicose: Oral manifestations and sistemic implications

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    L. Janete Grando

    2010-12-01

    Full Text Available La paracoccidioidomicosis es una infección causada por un hongo P. brasiliensis. Se trata de una micosis profunda y sistémica, es considerada una enfermedad endémica en Brasil y en otros países de América Latina. El hongo es adquirido por inhalación, dando lugar a un cuadro clínico pulmonar que puede posteriormente afectar a la piel, mucosa oral, nasal y gastrointestinal; también el bazo y el hígado pueden verse afectados. Es frecuente encontrar linfadenopatías, y verse afectada la glándula suprarrenal y todas las vísceras, causando la muerte del paciente. Las úlceras orales suelen ser lesiones muy dolorosas, por ello el paciente acude a consulta para ser evaluado clínicamente por su odontólogo o estomatólogo. El diagnóstico precoz es la mejor manera de salvar al paciente de las complicaciones de la enfermedad. El número creciente de inmigrantes latinos puede hacer que esta importante enfermedad empiece a ser más prevalente en los países de la Comunidad Europea, por ello conocer en profundidad las características clínicas de esta infección por parte de los odontólogos europeos, es fundamental para llegar a diagnosticarla de forma temprana.Paracoccidioidomycosis is an infection caused by the p. brasiliensis fungus. This is a deep, systemic fungal infection considered endemic in Brazil and some Latin American countries. The fungus is acquired by inhalation, resulting in a pulmonary disease which may also affect the skin, oral, nasal and gastrointestinal mucosa, as well as the spleen and liver. Patients commonly present lymphadenopathy. The resulting adrenal gland and visceral involvement can be fatal. Oral lesions are often very painful leading the patient to the dentist or stomatologist for a clinical evaluation. Early diagnosis is the best way to avoid serious complications of the disease. The growing number of Latin immigrants may increase the prevalence of this important disease in the European Community, therefore, the

  13. Brote de una enfermedad en un plantel de pavos atribuido a enteritis hemorrágica Outbread of disease in turkeys farms attributed to haemorrhagic enteritis

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    S. DONOSO

    1999-01-01

    Full Text Available Para determinar la causa específica de una elevada mortalidad en un plantel de pavos, se recibieron 5 pavos en total, provenientes de tres lotes de 6, 7 y 8 semanas de edad realizándose en ellos necropsia y se recolectó muestras para estudio histopatológico, ultraestructural y bacteriológico. En la necropsia se observaron lesiones en intestino, el que se encontraba distendido, y con contenido sanguinolento en el lumen. Histopatológicamente se observó una enteritis hemorrágica, hiperemia e infiltrado de células mononucleares en la lámina propia, presentando algunas muestras una lesión necrótica, con presencia de colonias bacterianas. Los cultivos bacteriológicos mostraron crecimiento de Escherichia coli y en cultivos repetidos tres semanas después en los mismos lotes de pavos se aislo Pasteurella multocida. El bazo, se observó aumentado de tamaño, con un moteado gris blanquecino alternado con un fondo rojo oscuro, al corte. Histopatológicamente se observó amplias zonas de necrosis en los centros germinales y depleción, e hiperplasia de las células reticulares con presencia de cuerpos de inclusión intranucleares y marginación de la cromatina, correspondiendo ultraestructuralmente a centros de replicación viral, con partículas virales hexagonales de 55-58 nm de diámetro, que según tamaño y forma corresponderían a adenovirus aviar tipo IIThe pathological and ultraestructural changes detected in different organ samples obtained from commercial turkeys suffering a disease resembling hemorrhagic enteritis are described. At necropsy, the turkeys presented intestine lesions characterized by distention and bloody content. Histopathologically the lesions were characterized by hemorrhagic enteritis, hyperemia and mononuclear cell infiltration in the lamina propia. Some intestines had necrotic lesions which were attributed to a secondary bacterial infection. The spleen showed enlargement and a mottled gray-white appearance that

  14. enteritidis biovar Issatschenko en pollos de engorda

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    Griselda Ruiz Flores

    2008-01-01

    Full Text Available El objetivo del presente estudio fue determinar la patogenia de Salmonella enteritidis fagotipo 13a (SE FT 13a y de Salmonella enteritidis biovar Issatschenko fagotipo 6a (SI en pollitos de engorda de cuatro días de edad. Veintiocho aves por tratamiento fueron inoculadas con dosis de 1 × 108 (SE FT 13a y 1 × 109 (SI, respectivamente, y 14 pollitos fueron inoculados con solución salina fi siológica (SSF, como testigos negativos. Se tomaron muestras de hígado, bazo, corazón, pulmón, buche, duodeno, yeyuno, íleon y ciegos durante 14 tiempos posinfección (6, 18, 30, 42, 54, 78, 102, 126, 150, 174, 198, 222, 246 y 270 horas posinfección (hpi, para realizar el aislamiento bacteriológico de Salmonella spp, exámenes histopatológico y ultraestructural. Durante la primera semana, se observó que algunas aves estaban deprimidas, y en la segunda semana se encontraron aves con retención de saco vitelino en ambos tratamientos. Se aisló SE FT 13a a partir de las 18, 30, 42, 54, 78, 102, 126, 150, 174, 198, 246 y 270 hpi, en todos los órganos previamente descritos. SI fue aislada a las 42, 150, 174 y 222 hpi de muestras de buche, yeyuno, íleon y ciegos. El íleon fue el órgano de donde se aisló SE FT 13a y SI con mayor frecuencia. No se registró mortalidad en ningún tratamiento. El examen histopatológico reveló infl amación, necrosis coagulativa, congestión y hemorragias en tracto gastrointestinal (TGI y órganos viscerales a partir de las 6 hpi en ambos tratamientos, con grados de lesión de leve a severo. Ultraestructuralmente se observaron cambios en el citoplasma celular de enterocitos: degeneración, necrosis, invasión y penetración de SE FT 13a y SI. Los resultados de la presente investigación evidenciaron la capacidad de SE FT 13a y SI para penetrar e invadir enterocitos de los pollitos infectados experimentalmente, demostrando que SI es capaz de infectar pollos de engorda y no sólo a la familia Muridae.

  15. Rapid diagnosis and identification by PCR of Yersinia ruckeri isolated of Oncorhynchus mykiss from Canta, Lima, Peru Diagnóstico e identificación rápidos por PCR de Yersinia ruckeri aislada de Oncorhynchus mykiss procedentes de Canta, Lima, Perú

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    Susana Sirvas-Cornejo

    2012-02-01

    Full Text Available Twenty individuals of rainbow trout were sampled (fry and juveniles from Acochinchan Fishfarm (Canta, Lima - Peru, and analyzed with the Polimerase Chain Reaction test (PCR in order to achieve a rapid identification of Yersinia ruckeri, which is the pathogen agent that causes the enteric red mouth disease (ERM and produces high rates of mortality. Nine fish samples were asymptomatic, while 11 of them showed signs of ERM. In addition, 22 bacterial strains were isolated from the liver, spleen and kidney. PCR and specific primers (16S rRNA, were used to amplified a specific 575 bp DNA fragment of Yersinia ruckeri. Nineteen strains were identified as Yersinia ruckeri by PCR in symptomatic and asymptomatic fishes. It was established a diagnosis time of 26 hours, compared with the 2 or 3 days that would take the diagnosis using biochemical tests.Se muestrearon 20 ejemplares (alevines y juveniles de trucha arco iris cultivados en la piscifactoría Acochinchán (Canta, Lima, Perú, y se les aplico la técnica de la Reacción en Cadena de la Polimerasa (PCR con la finalidad de obtener una identificación rápida del agente patógeno Yersinia ruckeri que produce la enfermedad entérica de la boca roja (ERM y genera elevadas tasas de mortalidad. Nueve ejemplares fueron asintomáticos mientras que 11 presentaron signos de ERM. Se aislaron 22 cepas bacterianas del hígado, bazo y riñón. Se empleó la técnica de la PCR para la amplificación y cebadores específicos (ARNr 16S, que permitieron amplificar un fragmento de ADN de 575 pb de Yersinia ruckeri. Diecinueve cepas fueron identificadas como Yersinia ruckeri mediante la PCR, tanto en peces sintomáticos como asintomáticos. Se estableció un tiempo de diagnóstico de 26 horas, en comparación con los 2 ó 3 días que duraría el diagnóstico empleando las pruebas bioquímicas.

  16. Immunomodulating effects of hot-water extract from Pleurotus ostreatus mycelium on cyclophosphamide treated mice

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    H. J. Morris

    2003-01-01

    Full Text Available Con el objetivo de desarrollar nuevos agentes inmunoquimioterapéuticos, se ha producido un reciente resurgimiento en el interés por los hongos comestibles. Un extracto en agua caliente (F-I: 43.6%, w/w, de carbohidratos y un 28.0%, w/w de proteínas, preparado a partir del micelio de Pleurotus ostreatus, fue administrado intraperitonealmente (i.p. en dosis de 100 mg/kg durante 7 días a ratones Balb/c y la ciclofosfamida (CY, a razón de 10 mg/kg, fue inoculada el quinto día. La influencia de la administración de F-I sobre la inmunosupresión causada por CY fue evaluada el octavo día. Los ratones tratados con CY mostraron una inmunosupresión menos pronunciada y una recuperación hematopoyética más rápida cuando se les administró F-I. La inyección i.p. de F-I incrementó la celularidad de la médula ósea (4.1 x 106 vs. 1.5 x 106 por fémur en el grupo control tratado con solución salina, P< 0.01, los conteos leucocitarios (7.6 x 109 vs. 4.8 x 109 cells/l, P< 0.05 y duplicó el número de colonias macroscópicas endógenas de tejido hematopoyético en la superficie parietal del bazo (P< 0.05. F-I potenció el sistema reticuloendotelial murino, a juzgar por el menor tiempo de aclaramiento del carbón (4.23 vs. 6.18 min, P< 0.05. F-I incrementó el número de células presentes en el exudado peritoneal (P< 0.01 y estimuló in vivo el porciento de macrófagos fagocitantes (15.65% vs. 4.70%, P< 0.01 y el índice fagocítico (1.06 vs. 0.12, P< 0.05. No fueron observados signos de toxicidad, como hepatoesplenomegalia, en los ratones tratados con F-I. Estos efectos sugieren que F-I es capaz de potenciar los mecanismos de defensa del huésped in vivo.

  17. Estudio histopatológico entre ratones infectados con Salmonella typhi sin vacunar y vacunados por diferentes vías con las vacunas polisacarídica y de células enteras

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    Juan F. Infante

    2000-12-01

    Full Text Available La fiebre tifoidea constituye una enfermedad propia del hombre. La misma es causada por Salmonella typhi y produce una respuesta inflamatoria en el tracto intestinal. Con el fin de establecer su control por vacunación el Instituto Finlay ha desarrollado una vacuna a partir del polisacárido capsular Vi. Para su estudio experimental no existe un modelo animal que reproduzca los síntomas y la patogenia de la enfermedad. El desarrollo de modelos experimentales y los estudios histopatológicos aportan informaciones al conocimiento de la enfermedad y a la interpretación de los procesos inmunológicos. Nos propusimos caracterizar el cuadro histopatológico en los ratones utilizados en las pruebas de potencia de la vacuna antitifoídica basada en polisacárido Vi purificado y su comparación con la vacuna de células enteras. Se utilizaron 240 ratones de ambos sexos pertenecientes a la línea C57BL/6 procedentes del Centro Nacional para la Producción de Animales de Laboratorio (CENPALAB, con un peso comprendido entre 18 y 22 g. Se evaluó la protección comparativa entre las vías intraperitoneal y subcutánea utilizando dos inmunógenos, a partir del polisacárido Vi y con la variante de células enteras. Se logró una considerable eficacia en ratón C57BL/6 para reproducir las lesiones compatibles con Salmonella typhi en hígado y bazo. La sobrevivencia del grupo no vacunado fue de un 15%. La sobrevivencia de los ratones correspondientes al grupo vacunado con polisacárido Vi osciló entre 90% y 100% para ambas vías, mientras que los vacunados con células enteras variaron entre 50% y 100% para la vía subcutánea y entre 60% y 100% para la vía intraperitoneal todo lo cual evidencia la superioridad de la vacuna a partir del polisacárido capsular Vi sobre la variante de células enteras en la especie ratón C57BL/6

  18. Brote de histoplasmosis en la Escuela de Cadetes de la Base Aérea de Morón, Provincia de Buenos Aires, República Argentina Histoplasmosis outbreak in Morón, Buenos Aires Province, Argentina

    Directory of Open Access Journals (Sweden)

    R. Negroni

    2010-12-01

    Full Text Available Se describe un brote de histoplasmosis que afectó a 6 cadetes de la Fuerza Aérea Argentina, sin antecedentes patológicos previos. Todos consultaron por problemas respiratorios después de haber limpiado un hangar. En ese recinto se encontraron abundantes deyecciones de animales, presuntamente de palomas y murciélagos. Los pacientes sufrieron fiebre, mialgias, taquipnea y tos no productiva. Las radiografías y tomografías de tórax mostraron imágenes pulmonares micronodulares, engrosamiento de los tabiques interalveolares y adenopatías hiliares. Todos tuvieron una evolución favorable y no requirieron tratamiento antifúngico. Las pruebas de inmunodifusión y contrainmunoelectroforesis con antígenos de Histoplasma capsulatum fueron positivas, al igual que las intradermorreacciones con histoplasmina. Se recogieron 5 muestras de tierra del lugar, las que fueron inoculadas por vía intraperitoneal a 20 hámsteres. De los cultivos de hígado y bazo de dichos animales se consiguió aislar la fase micelial de H. capsulatum. La cepa aislada se comparó con las obtenidas de 12 pacientes argentinos utilizando perfiles genéticos y se observó un clado único con más de 96% de similitud, lo que confirma la homogeneidad de las cepas argentinas. Si bien la histoplasmosis es endémica en la Pampa húmeda, este es el primer brote totalmente documentado al sur del paralelo 34°.An histoplasmosis outbreak affecting 6 previously healthy Air Force cadets is herein presented. The patients suffered from fever and respiratory symptoms after having cleaned an abandoned hangar soiled with pigeons and bat droppings. They all presented fever, myalgia, tachypnea, and nonproductive cough. Chest X-ray and CT scan studies showed disseminated reticulonodular images affecting both lungs. Hiliar adenomegalies were also observed. All patients achieved a favourable outcome without antifungal treatment. Both serologic tests searching for specificic antibodies

  19. Influenza aviar: histopatología y detección viral por RT-PCR en tejidos fijados con formalina e incluidos en parafina

    Directory of Open Access Journals (Sweden)

    Roberto Padilla Noriega

    2004-01-01

    Full Text Available Se estableció la técnica de transcripción reversa-reacción en cadena de la polimerasa (RT-PCR para la detección del virus de influenza aviar en tejidos de aves infectadas experimentalmente, incluidos en parafina, lo cual se correlacionó con las lesiones histológicas. Se inocularon por vía intravenosa ocho equilotes de diez pollos Arbor Acres de cinco semanas de edad, con 101 a 108 dosis letales de pollo del 50% (DLP50 del virus de influenza aviar A/Ck/Querétaro/20/95 (H5N2. Todas las aves se sometieron a evaluación histopatológica. Se ensayaron por RT-PCR tres tipos de tejidos incluidos en parafina (un ave por dosis: pulmón, encéfalo y riñón. Las principales lesiones histológicas observadas en las aves infectadas incluyeron necrosis del tejido linfoide (en pulmón, bazo, bolsa de Fabricio y tonsilas cecales, vasculitis, necrosis tubular aguda, encefalitis no supurativa y necrosis multifocal en los órganos examinados. Las principales diferencias con otras cepas altamente patogénicas ?peste de las aves (H7N7, Ck/Scot/59 (H5N1, Tern/SA (H5N3, Ty/Ont/66 (H5N9 y Ck/Penn/83 (H5N2? fueron: mayor frecuencia de daño vascular, nefropatogenicidad, necrosis en islotes pancreáticos y necrosis difusa del tejido linfoide. Estos hallazgos le confieren a la cepa bajo estudio características propias distintivas. Se detectó virus de influenza en pulmón con la técnica de RT-PCR, independientemente de la dosis, y en encéfalo y riñón en siete de las ocho dosis empleadas, lo cual indica que el virus se replica en estos tejidos; los cambios patológicos observados pueden atribuirse a la replicación viral, sin excluir la participación de otros mecanismos de daño celular.

  20. Non-destructive inspection protocol for reinforced concrete barriers and bridge railings

    International Nuclear Information System (INIS)

    Reinforced concrete highway barriers and bridge railings serve to prevent errant vehicles from departing the travel way at grade separations. Despite the important role that they play in maintaining safety and their ubiquitous nature, barrier inspection rarely moves beyond visual inspection. In August 2008, a tractor-trailer fatally departed William Preston Lane, Jr. Memorial Bridge after it dislodged a section of the bridge barrier. Investigations following the accident identified significant corrosion of the anchor bolts attaching the bridge railing to the bridge deck. As a result of the information gathered during its investigation of the accident, the National Transportation Safety Board (NTSB) made recommendations to the Federal Highway Administration concerning Non-Destructive Evaluation (NDE) of concrete bridge railings. The Center for nondestructive evaluation (NDE) at Turner Fairbank Highway Research Center in McLean, VA is currently evaluating feasibility of using four technologies - ground penetrating radar (GPR), ultrasonic pulse-echo, digital radiography and infrared thermal imaging methods to develop bridge inspection methods that augment visual inspections, offer reliable measurement techniques, and are practical, both in terms of time and cost, for field inspection work. Controlled samples containing predefined corrosion levels in reinforcing steel were embedded at barrier connection points for laboratory testing. All four NDE techniques were used in the initial phase I testing. An inspection protocol for detecting and measuring the corrosion of reinforced steel embedded in the anchorage system will be developed as part of phase II research. The identified technologies shall be further developed for field testing utilizing a structure with a barrier in good condition and a structure with a barrier in poor condition

  1. Non-destructive inspection protocol for reinforced concrete barriers and bridge railings

    Science.gov (United States)

    Chintakunta, Satish R.; Boone, Shane D.

    2014-02-01

    Reinforced concrete highway barriers and bridge railings serve to prevent errant vehicles from departing the travel way at grade separations. Despite the important role that they play in maintaining safety and their ubiquitous nature, barrier inspection rarely moves beyond visual inspection. In August 2008, a tractor-trailer fatally departed William Preston Lane, Jr. Memorial Bridge after it dislodged a section of the bridge barrier. Investigations following the accident identified significant corrosion of the anchor bolts attaching the bridge railing to the bridge deck. As a result of the information gathered during its investigation of the accident, the National Transportation Safety Board (NTSB) made recommendations to the Federal Highway Administration concerning Non-Destructive Evaluation (NDE) of concrete bridge railings. The Center for nondestructive evaluation (NDE) at Turner Fairbank Highway Research Center in McLean, VA is currently evaluating feasibility of using four technologies - ground penetrating radar (GPR), ultrasonic pulse-echo, digital radiography and infrared thermal imaging methods to develop bridge inspection methods that augment visual inspections, offer reliable measurement techniques, and are practical, both in terms of time and cost, for field inspection work. Controlled samples containing predefined corrosion levels in reinforcing steel were embedded at barrier connection points for laboratory testing. All four NDE techniques were used in the initial phase I testing. An inspection protocol for detecting and measuring the corrosion of reinforced steel embedded in the anchorage system will be developed as part of phase II research. The identified technologies shall be further developed for field testing utilizing a structure with a barrier in good condition and a structure with a barrier in poor condition.

  2. Manipulation of a free-floating object using a macro/mini-manipulator with structural flexibility

    Science.gov (United States)

    Stevens, Homer Darling

    A new generation of operational robots is being developed that offers many exciting capabilities such as the capture of errant satellites, and the removal of nuclear waste from a large temporary storage tank. These tasks illuminate the particularly challenging problem of bringing a robot that exhibits structural flexibility into stable contact with free-floating objects in the environment. Interaction with a dynamic object imposes a relationship between the manipulator's position and the contact force that is well modeled as a generalized impedance. Controlling the manipulator's dynamic response to follow that of a specified impedance function complementary to the impedance of the dynamic object enables smooth interaction with that object. This type of control, called impedance control, provides a unified approach to both unconstrained and constrained motion in an uncertain, dynamic environment. The benefits of impedance control have been demonstrated using "rigid" robots, that is robots where the fundamental frequency of the structural vibration modes is several orders of magnitude higher than the task bandwidth. This research extends the application of impedance control to a large, structurally flexible macro-manipulator carrying a small rigid mini-manipulator. One example of this class of robots is the Space Station Remote Manipulator System and Special Purpose Dextrous Manipulator combination currently under development. This dissertation presents new synthesis concepts that enable impedance control to be achieved for the first time using a structurally flexible macro/mini-manipulator. The theoretical developments are experimentally demonstrated using a macro/mini-manipulator with significant structural flexibility. These results demonstrate fine, gentle contact with an object fixed in the environment, gentle initial contact and the firm maintenance of contact with an object completely free to move in the environment, and the prompt capture, by stopping all

  3. Detailed assessment of isotope ratio infrared spectroscopy and isotope ratio mass spectrometry for the stable isotope analysis of plant and soil waters

    Science.gov (United States)

    Zhao, L.; Xiao, H.; Zhou, J.; Wang, L.; Cheng, G.; Zhou, M.; Yin, L.; McCabe, M. F.

    2011-12-01

    As an alternative to isotope ratio mass spectrometry (IRMS) the isotope ratio infrared spectroscopy (IRIS) approach has the advantage of low cost, continuous measurement and capacity for field based application for the analysis of stable water isotopes. Recent studies have indicated that there are potential issues of organic contamination of the spectral signal in the IRIS method, resulting in errant readings for leaf samples. To gain a more thorough understanding of the effects of sample type (e.g., leaf, root, stem and soil), sample species, sampling time and climatic condition (dry vs. wet) on water isotope estimates using IRIS, we collected soil samples and plant components from a number of major species at a fine temporal resolution (every two hours for 24-48 hours) across three locations with different climatic conditions in the Heihe River Basin, China. The hydrogen and oxygen isotopic composition of the extracted water from these samples was measured using both an IRMS and IRIS instrument. Results show that the mean discrepancy between the IRMS and IRIS approach, for δ18O and δD respectively, was: -5.6% and -75.7% for leaf water; -4.0% and -23.3% for stem water; -3.4% and -28.2% for root water; -6.7% and -0.5% for xylem water; -0.06% and -0.3% for xylem flow; and -0.1% and 0.3% for soil water. The order of the discrepancy followed: leaf > stem ≈ root > xylem > xylem flow ≈ soil. In general, species of the same functional types (e.g., woody vs. herbaceous) within similar habitats showed similar deviations. For different functional types, the differences were large. Sampling during the nighttime did not remove the observed deviations.

  4. Muscle Articulations: Flexible Jaw Joints Made of Soft Tissues.

    Science.gov (United States)

    Uyeno, T A; Clark, A J

    2015-08-01

    This study surveys animals that use soft tissues rather than rigid links to build jaw joints. Hard biting elements are useful; they are used in piercing or shearing during feeding and interactive behaviors and can directly impact survival and reproduction. The best understood biting systems include biting elements that are mounted on rigid jaw links that form a joint capable of transmitting the bite reaction forces. As such, jaws must incorporate joints that resist compression. Many jaw joints are "sliding joints", in which jaw links come into direct contact and the shape of the sliding contact surfaces dictates possible motions. There are, however, organisms that have biting elements on jaws that are made of flexible muscle and connective tissues. If arranged as a muscular hydrostat, in which multiple orientations of the muscle fibers may co-contract to provide turgid skeletal support, the multifunctional joint not only (a) provides the force to move the biting elements, but also (b) creates repositionable pivots and (c) transmits bite reaction forces. Such flexible joints, termed "muscle articulations", may be important to a number of soft-bodied animals. In this survey, we review the function of previously described muscle articulations: the joints found between inarticulate brachiopods' valves, cephalopods' beaks, the hooks of kalyptorhynch flatworms, and errant polychaetes' jaws. We also review the morphology, physiology, and feeding behaviors of the hagfish as a putative muscle articulation in an effort to understand how this jawless craniate is capable of biting with surprising force, seemingly without the benefit of any obvious method of opposing the force of the dental plate that is used to remove portions of food. Initial analysis suggests that a muscle articulation may be a key feature in coordinating head and body movements to provide the leverage needed for strong "bites". PMID:25912361

  5. Neural basis of feature-based contextual effects on visual search behavior

    Directory of Open Access Journals (Sweden)

    Kelly eShen

    2012-01-01

    Full Text Available Searching for a visual object is known to be adaptable to context, and it is thought to result from the selection of neural representations distributed on a visual salience map, wherein stimulus-driven and goal-directed signals are combined. Here we investigated the neural basis of this adaptability by recording superior colliculus (SC neurons while three female rhesus monkeys (Macaca mulatta searched with saccadic eye movements for a target presented in an array of visual stimuli whose feature composition varied from trial to trial. We found that sensory-motor activity associated with distracters was enhanced or suppressed depending on the search array composition and that it corresponded to the monkey's search strategy, as assessed by the distribution of the occasional errant saccades. This feature-related modulation occurred independently from the saccade goal and facilitated the process of saccade target selection. We also observed feature-related enhancement in the activity associated with distracters that had been the search target during the previous session. Consistent with recurrent processing, both feature-related neuronal modulations occurred more than 60 ms after the onset of the visually evoked responses, and their near coincidence with the time of saccade target selection suggests that they are integral to this process. These results suggest that SC neuronal activity is shaped by the visual context as dictated by both stimulus-driven and goal-directed signals. Given the close proximity of the SC to the motor circuit, our findings suggest a direct link between perception and action and no need for distinct salience and motor maps.

  6. Benchmarking, Research, Development, and Support for ORNL Automated Image and Signature Retrieval (AIR/ASR) Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Tobin, K.W.

    2004-06-01

    This report describes the results of a Cooperative Research and Development Agreement (CRADA) with Applied Materials, Inc. (AMAT) of Santa Clara, California. This project encompassed the continued development and integration of the ORNL Automated Image Retrieval (AIR) technology, and an extension of the technology denoted Automated Signature Retrieval (ASR), and other related technologies with the Defect Source Identification (DSI) software system that was under development by AMAT at the time this work was performed. In the semiconductor manufacturing environment, defect imagery is used to diagnose problems in the manufacturing line, train yield management engineers, and examine historical data for trends. Image management in semiconductor data systems is a growing cause of concern in the industry as fabricators are now collecting up to 20,000 images each week. In response to this concern, researchers at the Oak Ridge National Laboratory (ORNL) developed a semiconductor-specific content-based image retrieval method and system, also known as AIR. The system uses an image-based query-by-example method to locate and retrieve similar imagery from a database of digital imagery using visual image characteristics. The query method is based on a unique architecture that takes advantage of the statistical, morphological, and structural characteristics of image data, generated by inspection equipment in industrial applications. The system improves the manufacturing process by allowing rapid access to historical records of similar events so that errant process equipment can be isolated and corrective actions can be quickly taken to improve yield. The combined ORNL and AMAT technology is referred to hereafter as DSI-AIR and DSI-ASR.

  7. Detección inmunohistoquímica del antígeno del virus del síndrome respiratorio y reproductivo (vPRRS en cerdos inoculados Immunohistochemical detection of PRRS virus antigen in inoculated pigs

    Directory of Open Access Journals (Sweden)

    M. Quezada

    2004-12-01

    Full Text Available El Síndrome Respiratorio y Reproductivo Porcino (PRRS es una enfermedad de origen viral en el cerdo que se conoce desde la década de los 80 en Estados Unidos. La enfermedad se caracterizó inicialmente por propagarse rápidamente entre los planteles porcinos, difundiéndose casi a todos los Estados Unidos y luego a Canadá y países europeos. En Chile, el PRRS se diagnosticó a fines de 1999 y en la actualidad está sometida a un programa de erradicación. Con el fin de contribuir al diagnóstico de la enfermedad en nuestro medio y caracterizar la distribución del antígeno vírico en los tejidos de cerdos inoculados, se realizó un estudio inmunohistoquímico (IHQ, utilizando 12 cerdos híbridos provenientes de planteles con pirámide genética libre de PRRS. De ellos, 9 fueron inoculados con el aislado nacional del virus PRRS y 3 cerdos se usaron como controles. Los cerdos inoculados recibieron una dosis por vía intranasal de 7.0 ml de suero virémico, proveniente de cerdos inoculados con una dosis de 10(5.4 TCID50; para reactivar el virus; además, se inocularon estos animales con 0.7 ml del mismo suero por vía intramuscular. Los cerdos del grupo control fueron sacrificados a los 0 dpi y los cerdos inoculados a los 7, 14, 21 dpi. De todos los animales se recolectaron muestras de tonsila, nódulos linfáticos retrofaríngeos y mediastínicos, timo, bazo, cornete nasal, pulmón, corazón e hígado, las que fueron fijadas, deshidratadas e incluidas en parafina. Adicionalmente, se obtuvieron muestras de macrófagos alveolares pulmonares mediante lavado bronquioalveolar. Todas las muestra fueron inmunoteñidas usando el anticuerpo monoclonal SDOW-17 y el método del complejo ABC. Se detectó antígeno viral en macrófagos de todos los tejidos estudiados desde los 7 a los 21 dpi. Los órganos que presentaron mayor intensidad de reacción fueron el pulmón y el bazo. Debido a que el antígeno viral se encontró en mayor cantidad y de forma m

  8. Ocorrência de leishmaniose tegumentar em cães de área endêmica no Estado do Paraná Occurrence of cutaneous leishmaniasis in dogs of endemic area, Paraná State

    Directory of Open Access Journals (Sweden)

    E. Pittner

    2009-06-01

    Full Text Available Investigou-se a infecção por parasitas do complexo Leishmania braziliensis em 50 cães da cidade de Maringá, PR, onde ocorreram casos humanos de leishmaniose tegumentar americana (LTA, entre agosto e dezembro de 2006. Os casos humanos de LTA ocorreram nos anos de 2003 a 2004. Nenhum animal apresentou lesão, mas 12 (24,0% tinham sorologia e/ou PCR positivas, e a positividade tanto da IFI como da PCR foi de 14,0%. Trinta e cinco animais eram de residências, e oito deles (22,8% tiveram testes laboratoriais para LTA positivos. Os outros 15 eram cães errantes, sendo que quatro deles (26,7% apresentaram PCR positiva. A presença de animais com infecção assintomática por Leishmania em área onde a LTA é endêmica pode ser um indicador do potencial de sua transmissão para o homem e uma referência para a implantação de medidas de controle e prevenção da doença.The infection by Leishmania braziliensis complex was studied in 50 dogs from Maringá, PR, where American Cutaneous Leishmaniasis (ACL in humans have been detected. Data were collected from August to December 2006 in an area in which ACL cases in humans were reported from 2003 to 2004. Indirect immunofluorescent test (IIF and polymerase chain reaction (PCR were applied. No lesions were found in the animals, although 12 (24.0% had positive IIF and/or PCR. Positiveness was 14.0% for IIF and PCR. Lab tests showed that eight (22.8% out of the 35 home animals were ACL positive. The other 15 animals were stray dogs, out of which four (26.7% were PCR positive. The appearance of asymptomatic Leishmania-infected dogs in an ACL endemic area may be an indicator of ACL transmission potential for humans and a reference for the establishment of control measures and disease prevention.

  9. Contaminação do solo por ovos de geo-helmintos com potencial zoonótico na municipalidade de Fernandópolis, Estado de São Paulo, entre 2007 e 2008

    Directory of Open Access Journals (Sweden)

    Alex Jones Flores Cassenote

    2011-06-01

    Full Text Available INTRODUÇÃO: A concentração de cães e gatos em áreas urbanas, associada a um número cada vez mais crescente da população errante desses animais, tem um papel epidemiológico importante na contaminação de solos de praças e parques públicos e na disseminação de infecções por variados gêneros de parasitas. O objetivo do presente estudo foi determinar a frequência de geo-helmintos com potencial zoonótico em solo de praças públicas e escolas municipais infantis da Cidade de Fernandópolis, Estado de São Paulo, Brasil, no período compreendido entre março de 2007 e fevereiro de 2008. MÉTODOS: Foram avaliadas todas as praças (32 e escolas (13 da cidade. As amostras foram testadas pelos métodos de Rugai adaptado, Willis e Caldwell e Caldwell. RESULTADOS: Foram avaliadas 225 amostras de solo com 30,2% (68 de positividade. Nas amostras provenientes de praças públicas, a positividade foi de 40% (64, ao passo que, nas escolas, foi de apenas 6,1% (6. Os ovos de parasitas encontrados foram Toxocara spp. 79,3% (47, Trichuris spp. 13,8% (8 e ancilostomídeos 6,9% (4. Variáveis relacionadas ao local, como o número de cães (OR 21,18 - IC95%: 10,81-41,51, de espécimes de fezes (OR 6,87 - IC95%: 3,51-13,47 e a utilização de cerca (OR 0,1 - IC95%: 0,05-0,20 tiveram impacto na contaminação do solo. CONCLUSÕES: Foram observados, nas amostras contaminadas, parasitas com potencial zoonótico, entre os quais estão os agentes etiológicos de doenças como a larva migrans visceral e cutânea, fato que representa risco a saúde da população que frequenta tais ambientes.

  10. Keeping the Air Clean and Safe: An Anthrax Smoke Detector

    Science.gov (United States)

    2005-01-01

    Scientists at work in the Planetary Protection division at NASA s Jet Propulsion Laboratory (JPL) sterilize everything before blasting it to the Red Planet. They take great pains to ensure that all spacecraft are void of bacterial life, especially the microscopic bacteria that can live hundreds of years in their spore states. No one is quite sure what Earthly germs would do on Mars, but scientists agree that it is safest to keep the Martian terrain as undisturbed as possible. Errant Earth germs would also render useless the instruments placed on exploration rovers to look for signs of life, as the life that they registered would be life that came with them from Earth. A team at JPL, headed by Dr. Adrian Ponce, developed a bacterial spore-detection system that uses a simple and robust chemical reaction that visually alerts Planetary Protection crews. It is a simple air filter that traps micron-sized bacterial spores and then submits them to the chemical reaction. When the solution is then viewed under an ultraviolet light, the mixture will glow green if it is contaminated by bacteria. Scientists can then return to the scrubbing and cleaning stages of the sterilization process to remove these harmful bacteria. The detection system is the space-bound equivalent of having your hands checked for cleanliness before being allowed to the table; and although intended to keep terrestrial germs from space, this technology has awesome applications here on Mother Earth. The bacterial spore-detection unit can recognize anthrax and other harmful, spore-forming bacteria and alert people of the impending danger. As evidenced in the anthrax mailings of fall 2001 in the United States, the first sign of anthrax exposure was when people experienced flu-like symptoms, which unfortunately, can take as much as a week to develop after contamination. Anthrax cost 5 people their lives and infected 19 others; and the threat of bioterrorism became a routine concern, with new threats popping up

  11. Confocal analysis of nervous system architecture in direct-developing juveniles of Neanthes arenaceodentata (Annelida, Nereididae

    Directory of Open Access Journals (Sweden)

    Jacobs David K

    2010-06-01

    Full Text Available Abstract Background Members of Family Nereididae have complex neural morphology exemplary of errant polychaetes and are leading research models in the investigation of annelid nervous systems. However, few studies focus on the development of their nervous system morphology. Such data are particularly relevant today, as nereidids are the subjects of a growing body of "evo-devo" work concerning bilaterian nervous systems, and detailed knowledge of their developing neuroanatomy facilitates the interpretation of gene expression analyses. In addition, new data are needed to resolve discrepancies between classic studies of nereidid neuroanatomy. We present a neuroanatomical overview based on acetylated α-tubulin labeling and confocal microscopy for post-embryonic stages of Neanthes arenaceodentata, a direct-developing nereidid. Results At hatching (2-3 chaetigers, the nervous system has developed much of the complexity of the adult (large brain, circumesophageal connectives, nerve cords, segmental nerves, and the stomatogastric nervous system is partially formed. By the 5-chaetiger stage, the cephalic appendages and anal cirri are well innervated and have clear connections to the central nervous system. Within one week of hatching (9-chaetigers, cephalic sensory structures (e.g., nuchal organs, Langdon's organs and brain substructures (e.g., corpora pedunculata, stomatogastric ganglia are clearly differentiated. Additionally, the segmental-nerve architecture (including interconnections matches descriptions of other, adult nereidids, and the pharynx has developed longitudinal nerves, nerve rings, and ganglia. All central roots of the stomatogastric nervous system are distinguishable in 12-chaetiger juveniles. Evidence was also found for two previously undescribed peripheral nerve interconnections and aspects of parapodial muscle innervation. Conclusions N. arenaceodentata has apparently lost all essential trochophore characteristics typical of

  12. Territorialidade homoerótica: apontamentos para os estudos de gênerico Homoerotic territoriality: notes for studies on gender

    Directory of Open Access Journals (Sweden)

    Maria Juracy Filgueiras Toneli

    2006-12-01

    Full Text Available Este trabalho é resultado de uma pesquisa cujo objetivo foi investigar as relações sociais engendradas por mulheres que se relacionam afetiva e sexualmente com outras mulheres e que freqüentavam um espaço reconhecido como gueto GLS (gays, lésbicas e simpatizantes. A pesquisa foi desenvolvida como exercício etnográfico, com dados obtidos a partir de observações de campo e de entrevistas. Os dados foram analisados a partir da análise de conteúdo. Este artigo privilegia a abordagem dos sentidos atribuídos às relações que se estabelecem nesse espaço que se revela como mediação para constituição dos sujeitos. Destaca a territorialidade itinerante, o trânsito e as posições dos sujeitos em redes de sociabilidades. Os resultados evidenciam uma perspectiva de manutenção desses espaços sob uma configuração que se refere à separação dos públicos, muito mais do que uma possível agregação de diferentes públicos em locais compartilhados livremente. Contemplam problemáticas de igualdade/diferença, (invisibilidade, proteção, exclusão, tolerância e preconceito.This paper is the result of a research that investigated the social relations of women who have affective and sexual relationships with other women and who socialized at a place recognized as a GLS (gay, lesbian and sympathizers ghetto. The research was developed as an ethnographic exercise, obtaining data through field observations and interviews. The data was analyzed by content analysis. This article privileges the approach of the meanings attributed by these women to the relations they have established at that location, and that is revealed as being a mediation in constituting the subjects. The errant territoriality, transit and the positions of the subjects in networks of sociability are highlighted. The results shows us a perspective of maintaining these places under a configuration that refers to the separation of people much more than a possible

  13. ODISEO CREATIVO: UN CAPÍTULO DE LA HISTORIA REMOTA DE LA CREATIVIDAD

    Directory of Open Access Journals (Sweden)

    Ricardo López Pérez

    2010-04-01

    Full Text Available En un remoto pasado, griegos y troyanos se enfrentaron en una extensa lucha. Los primeros sitiaron la ciudad de Troya hasta destruirla a sangre y fuego. La mayoría de los detalles se perdieron, pero nuestra cultura conservó fragmentos importantes gracias a la composición oral y al canto público de poetas errantes de prodigiosa memoria, llamados aedos o rapsodas, que luego fueron la base de textos que aún podemos leer. En el centro de esta historia, emerge la figura del primer pensador creativo del que tenemos recuerdo. Se trata de Odiseo, o bien Ulises en su forma latina, cuya sinuosa vida está extraordinariamente bien documentada, considerando la distancia que nos separa de ella. Transgrediendo prácticas habituales y esquemas consagrados, propios de su época, introdujo sistemáticamente nuevas formas de enfrentar los peligros y resolver los problemas. En cada acción representó un ejemplo de prudencia, tenacidad y capacidad de respuesta, pero en sus empeños jamás sometió el núcleo permanente de su existencia, su sentido de vida, a ganancias pasajeras. Ningún poeta habla todavía de creatividad, en cambio encontramos el vocablo metis, seguramente su antecedente más lejano.In ancient times, Greeks and Trojans encountered each other in a fight of many years. The former besieged the city of Troy and destroyed it by blood and fire. Most of the details were lost, but our culture has kept important fragments of them thanks to the oral compositions and public singing of wandering poets gifted with a powerful memory known as aedos, or rhapsodes, which then became the basis for texts that we can still read today. From the center of this history emerges the figure of the first creative thinker that we can remember This is Odysseus, or rather Ulysses, in its Latin version, whose sinuous life is extraordinarily well documented considering the distance separating us from it. Despite habitual practices and consecrated schemas of his time, he

  14. Role of intestinal bacterial overgrowth and intestinal motility in bacterial translocation in experimental cirrhosis Papel del sobrecrecimiento bacteriano intestinal y de la motilidad intestinal en la traslocación bacteriana en un modelo experimental de cirrosis

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    E. Sánchez

    2005-11-01

    ígado, bazo, y muestras cecales de todos los animales. Además se determinó el tiempo de tránsito intestinal en 10 ratas cirróticas y en 10 controles. Resultados: la prevalencia de la traslocación bacteriana en los animales cirróticos fue de un 56%. La población de gérmenes aerobios en el ciego en las ratas cirróticas fue significativamente mayor (p < 0,01 que en las ratas controles. Las ratas cirróticas con TB presentaron un población bacteriana intestinal más elevada que las ratas sin TB (p < 0,05. La prevalencia de SBI en los animales cirróticos fue de un 67% frente a un 0% en los animales control (p < 0,01; también el SBI fue más frecuente en las ratas cirróticas con TB que en las cirróticas sin TB (93 vs. 33% (p < 0,01. De las bacterias que traslocaron un 95,6% presentaban sobrecrecimiento en ciego. El tránsito intestinal fue más lento en las ratas cirróticas (60,5 ± 12,7 vs. 81,2 ± 5,7 cm que en los animales controles (p < 0,01. Conclusiones: estos resultados sugieren que el sobrecrecimiento bacteriano es frecuente en ratas cirróticas y predispone al desarrollo de traslocación bacteriana intestinal. Además, este sobrecrecimiento probablemente está favorecido por la existencia de una dismotilidad intestinal, frecuente en este modelo de cirrosis experimental.

  15. Detección de viremia en la infección experimental por Rubulavirus porcino Detection of viremia in the Porcine rubulavirus experimental infection

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    J Reyes-Leyva

    2004-01-01

    Full Text Available El rubulavirus porcino (RVP es causante de la enfermedad del ojo azul, que se manifiesta como una meningoencefalitis progresiva fatal en cerdos lactantes y con alteraciones reproductivas en cerdos adultos. El RVP es detectado principalmente en sistema nervioso central, sin embargo, también se ha logrado aislar de otros órganos como bronquios, pulmones, testículos, epidídimo, próstata, ovarios, páncreas, hígado, bazo, timo y nódulos linfáticos. Estos datos sugieren que existe una fase de viremia que permite la diseminación viral del sitio de inoculación hacia otros órganos. En este trabajo presentamos evidencia del estado de viremia así como el análisis de diversos parámetros sanguíneos en cerdos pospúberes infectados experimentalmente con el RVP. El virus se identificó asociado a eritrocitos del día 4 al 12 post-inoculación (p.i. y asociado a leucocitos del día 12 al 20 p.i., lo que sugiere que utiliza estas células como medio de diseminación sistémica. La producción de anticuerpos se identificó desde la primera semana p.i., pero los títulos más elevados se encontraron el día 16 p.i., lo que coincidió con la eliminación del virus libre en sangre. Ninguno de los animales infectados mostró anormalidades en la biometría hemática durante la fase de viremia.The Porcine rubulavirus (PoRV is the causal agent of Blue Eye Disease, an endemic disease in Mexico known since 1980, which is characterised by a progressive fatal meningo-encephalitis in piglets and reproductive failure in adults pigs, accompanied with respiratory symptoms and corneal opacity. PoRV mainly replicates in the respiratory and central nervous system, however, it is also detected in other organs such as testis, epididymis, prostate, ovaries, spleen, liver, thymus and lymphatic nodes. These findings suggest the existence of a viremic phase that leads to a systemic virus spread. In this paper we study the viremia in experimentally PoRV-infected post

  16. Carcinoma de células escamosas con invasión múltiple en abdomen en una oveja Rasa Aragonesa (Scaly cells carcinoma with multiple invasion in abdomen in a Rasa Aragonesa Sheep

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    Loste, A.

    2009-05-01

    Full Text Available ResumenUna oveja de raza Rasa Aragonesa, procedente de una explotación de laprovincia de Zaragoza, fue remitida a la Facultad de Veterinaria,presentando un historial de descarga vaginal sanguinolenta, oscura ymaloliente, por lo que se sospechó de un proceso de metritis y seadministró oxitocina para favorecer la eliminación de la secreción. Otros síntomas encontrados tras la exploración fueron caquexia, palidez de mucosas y debilidad. A la palpación del abdomen se detectaron varios nódulos, destacando por su tamaño uno localizado en la región umbilical, que podían corresponder con abscesos.El estado de la oveja empeoró progresivamente, por lo que se decidió su sacrificio humanitario. En la necropsia de observaron múltiples nódulos distribuidos en la zona abdominal (peritoneo, hígado y bazo, y uno de enorme tamaño localizado en el cuello del útero. No se encontraron lesiones en ninguna otra localización. Se tomaron muestras para el estudio anatomopatológico, que dio como resultado un carcinoma de células escamosas. Los carcinomas de células escamosas se han descrito en ganado ovino localizados en cabeza (fosas nasales y tercer párpado, asociados normalmente a una alta exposición a radiaciones solares en zonas desprotegidas de la piel y mucosas. En la bibliografía no se ha encontrado ninguna descripción de carcinoma de células escamosas de localización abdominal en ganado ovino. Dado que no se encontró en la necropsia ningún foco primario de localización típica en esta especie, se especula con el posible origen de la neoplasia a nivel del cuello del útero.SummaryA Rasa Aragonesa sheep from a flock of Zaragoza (Spain, was sent to the Veterinary Faculty with a history of bleeding, dark and smelly vaginal discharge. Metritis was suspected and treated with oxitocina in order to eliminate the secretion. Clinical exploration reveled caquexia, mucous paleness and weakness, and also several nodules were detected by

  17. Análisis de la resistencia inmune en un modelo murino experimental alimentado con dietas lipídicas e infectado con Listeria monocytogenes Analysis of the immune resistance in an experimental murine model fed dietary lipids and infected with Listeria monocytogenes

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    M.ª A. Puertollano

    2004-11-01

    Full Text Available Algunas dietas lipídicas están implicadas en la reducción de ciertas funciones inmunes. Sin embargo, la acción inmunosupresora de estas dietas puede tener efectos adversos sobre la resistencia inmune del individuo frente a enfermedades de naturaleza infecciosa. En el presente estudio tratamos de valorar el estado inmune de ratones alimentados con dietas lipídicas e infectados experimentalmente con una cepa virulenta de Listeria monocytogenes. Ratones de la raza Balb/c fueron divididos en cuatro grupos alimentados cada uno de ellos con su respectiva dieta: dieta baja en lípidos (control, 2,5%, dieta rica en aceite de oliva (AO, 20%, dieta rica en aceite de pescado (AP, 20% y dieta rica aceite de coco (AC, 20%. Los animales fueron alimentados durante un mes y posteriormente infectados con L. monocytogenes por vía endovenosa. Los resultados han mostrado una reducción de la supervivencia en animales alimentados con AP, así como un incremento significativo en el número de bacterias viables aisladas a partir de bazo. Además hemos podido observar un aumento de la capacidad bactericida de células peritoneales procedentes de ratones alimentados con AO, aunque la invasividad de L. monocytogenes en este grupo fue mayor que en el resto. Finalmente, una reducción significativa de la linfoproliferación fue observada en el grupo alimentado con AP, mientras que la actividad de células natural killer (NK no se ha visto modificada. Estos resultados indican que dietas lipídicas constituidas por ácidos grasos poliinsaturados de la serie n-3 reducen la resistencia inmune de los ratones, mientras que una dieta constituida por AO no produce un efecto inmusupresor tan relevante y por consiguiente no reduce drásticamente la resistencia inmune siendo más eficiente en la eliminación de L. monocytogenes.Several dietary lipids are capable of exerting an immunosupressor effect. This action may have undiserable effects on the host immune resistance to

  18. Estudio comparativo de las comunidades de arañas (Araneae en cultivos de algodón convencional y transgénico en el departamento del Tolima, Colombia

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    Flórez Daza Eduardo

    2005-07-01

    dos cultivos por lo que se concluye que la comunidad de arañas en el cultivo de algodón convencional es similar a la comunidad del cultivo de algodón Bt. Adicionalmente, se evaluaron los estratos vegetativo y suelo en los dos tipos de cultivo. Para el estrato vegetativo hubo una mayor abundancia de individuos en el algodón convencional (501 comparado con el algodón Bt (493. Sin embargo, esta diferencia no fue significativa. En este estrato vegetativo la familia más abundante fue Theridiidae para los dos tipos de cultivos. En el estrato suelo hubo una mayor abundancia de arañas en el cultivo Bt, determinada principalmente por la  amilia Linyphiidae con 759 individuos. Los gremios de arañas registrados en general para los cultivos de algodón convencional y Bt fueron tejedoras en sábana, tejedoras orbiculares, tejedoras irregulares, tejedoras en embudo, errantes en suelo, errantes en follaje, cazadoras al acecho y cazadoras en emboscada. El gremio más abundante fue el de tejedoras en sábana determinado por la extraordinaria abundancia de la familia Linyphiidae. En términos generales la composición, abundancia, riqueza y diversidad entre los dos cultivos fue similar, que lleva a concluir que no existe un efecto negativo del algodón Bt sobre la aracnofauna y que estos organismos, dado su papel depredador, pueden formar parte de un plan de manejo de plagas como controladores biológicos. Adicionalmente, se destacó la presencia de las especies Erigoninae 1, Theridion sp.1 y Theridula sp.2, como importantes para los cultivos de algodón.

  19. Serosurvey for tick-borne diseases in dogs from the Eastern Amazon, Brazil Pesquisa Sorológica por doenças transmitidas por carrapatos em cães da Amazônia oriental, Brasil

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    Mariana Granziera Spolidorio

    Full Text Available Canine ehrlichiosis and babesiosis are the most prevalent tick-borne diseases in Brazilian dogs. Few studies have focused attention in surveying tick-borne diseases in the Brazilian Amazon region. A total of 129 blood samples were collected from dogs living in the Brazilian eastern Amazon. Seventy-two samples from dogs from rural areas of 19 municipalities and 57 samples from urban stray dogs from Santarém municipality were collected. Serum samples were submitted to Indirect Immunofluorescence Assay (IFA with antigens of Babesia canis vogeli, Ehrlichia canis, and six Rickettsia species. The frequency of dogs containing anti-B. canis vogeli, anti-E. canis, and anti-Rickettsia spp. antibodies was 42.6%, 16.2%, and 31.7%, respectively. Anti-B. canis vogeli antibodies were detected in 59.6% of the urban dogs, and in 29.1% of the rural dogs (P Ehrliquiose canina e babesiose canina são as doenças parasitárias transmitidas por carrapatos de maior prevalência em cães do Brasil. Poucos estudos pesquisaram doenças transmitidas por carrapatos na região da Amazônia brasileira. Um total de 129 amostras de sangue foram colhidas de cães da Amazônia oriental brasileira. Setenta e dois cães eram de áreas rurais de 19 municípios do Estado do Pará, e 57 amostras foram colhidas de cães errantes vadios da área urbana do município de Santarém-PA. As amostras de soro foram submetidas ao ensaio de imunofluorescência indireta, com antígenos de Babesia canis vogeli, Ehrlichia canis, e seis espécies de Rickettsia. A frequência de cães com anticorpos anti-B. canis vogeli, anti-E. canis, e anti-Rickettsia spp. foi de 42,6%, 16,2% e 31,7%, respectivamente. Anticorpos anti-B. canis vogeli foram detectados em 59,6% dos cães urbanos, e em 29,1% dos cães rurais (P < 0.05. Para E. canis, a soroprevalência foi parecida entre os cães urbanos (15,7% e rurais (16,6%. Para Rickettsia spp., cães rurais apresentaram prevalência (P < 0.05 significativamente

  20. Dirofilariose canina na Ilha de São Luís, Nordeste do Brasil: uma zoonose potencial Canine heartworm on São Luís Island, Northeastern Brazil: a potential zoonosis

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    Silvia Maria Mendes Ahid

    1999-04-01

    Full Text Available Um inquérito sobre a prevalência da dirofilariose canina foi realizado entre 1.495 cães de 64 localidades na Ilha de São Luís, de 1991 a 1994, através da pesquisa de microfilárias. Desses, 1.358 cães (12,8% positivos não tinham história pregressa conhecida, sendo 1.265 errantes (10,3% microfilarêmicos e 93 domiciliados (37,8%. A dirofilariose foi detectada em 46 das localidade, porém a prevalência da infecção aumenta consideravelmente quando se trata de cães da orla marítima, de onde procederam 47% dos animais positivos. Em alguns bairros costeiros, a prevalência é elevada, como em Olho d'Água e Calhau (46% e 43% positivos, respectivamente. A pesquisa de microfilárias em 137 cães estritamente domiciliados (DO e com história pregressa conhecida (43% microfilarêmicos permitiu a comprovação da existência de transmissão na Ilha. Este estudo é o primeiro dessa natureza e abrangência realizado no Nordeste do País. Sabendo-se que a dirofilariose é uma zoonose, e diante da elevada prevalência de cães microfilarêmicos, particularmente os domiciliados da orla marítima da Ilha, chama-se a atenção para que se considere tal parasitose como possível causa de lesões pulmonares solitárias na população humana local e naquelas assentadas em áreas com clima e paisagem semelhantes no Nordeste.A survey on the prevalence of canine heartworm was conducted in 1,495 dogs from Maranhão Island, State of Maranhão, Northeastern Brazil, from 1991 to 1994, by testing for microfilariae in blood. Of the total, 1,358 (12.8% of which were infected were dogs with no known history; they included 1,265 homeless animals (10.3% with microfilariae and 93 kept by owners at the time the survey was conducted (37.8% of which were infected. Prevalence is high among dogs captured and/or living along the seashore. Examples of such high coastal prevalence rates were found in Olho d'Água and Calhau (46% and 43%, respectively. The search for

  1. Subgrain-scale decoupling of Re and 187Os and assessment of laser ablation ICP-MS spot dating in molybdenite

    Science.gov (United States)

    Stein, Holly; Scherstén, Anders; Hannah, Judith; Markey, Richard

    2003-10-01

    increased chemical stability in this mineral. Migration of 187Os into adjacent silicate phases is highly unlikely, but other contacting sulfides may take in Os. In an example from a Proterozoic skarn deposit at Pitkäranta (western Russia), we demonstrate minor loss of radiogenic 187Os from molybdenite and a corresponding gain in adjacent chalcopyrite such that the molybdenite age is not perceptibly disturbed, whereas the resulting chalcopyrite ages are impossibly old. Therefore, it is unadvisable to perform Re-Os analytical work on any sulfide in contact or intimate association with molybdenite. In addition to large errors in the age, if the isochron method is employed, initial 187Os/ 188Os ratios could be erroneously high, leading to seriously errant genetic interpretations.

  2. CD147 is a regulatory subunit of the gamma-secretase complex inAlzheimer's disease amyloid beta-peptide production

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Shuxia; Zhou, Hua; Walian, Peter J.; Jap, Bing K.

    2005-04-06

    {gamma}-secretase is a membrane protein complex that cleaves the {beta}-amyloid precursor protein (APP) within the transmembrane region, following prior processing by {beta}-secretase, producing amyloid {beta}-peptides (A{beta}{sub 40} and A{beta}{sub 42}). Errant production of A{beta}-peptides that substantially increases A{beta}{sub 42} production has been associated with the formation of amyloid plaques in Alzheimer's disease patients. Biophysical and genetic studies indicate that presenilin-1 (Psn-1), which contains the proteolytic active site, and three other membrane proteins, nicastrin (Nct), APH-1, and PEN-2 are required to form the core of the active {gamma}-secretase complex. Here, we report the purification of the native {gamma}-secretase complexes from HeLa cell membranes and the identification of an additional {gamma}-secretase complex subunit, CD147, a transmembrane glycoprotein with two immunoglobulin-like domains. The presence of this subunit as an integral part of the complex itself was confirmed through co-immunoprecipitation studies of the purified protein from HeLa cells and solubilized complexes from other cell lines such as neural cell HCN-1A and HEK293. Depletion of CD147 by RNA interference was found to increase the production of A{beta} peptides without changing the expression level of the other {gamma}-secretase components or APP substrates while CD147 overexpression had no statistically significant effect on amyloid {beta}-peptide production, other {gamma}-secretase components or APP substrates, indicating that the presence of the CD147 subunit within the {gamma}-secretase complex directly down-modulates the production of A{beta}-peptides. {gamma}-secretase was first recognized through its role in the production of the A{beta} peptides that are pathogenic in Alzheimer's disease (AD) (1). {gamma}-secretase is a membrane protein complex with unusual aspartyl protease activity that cleaves a variety of type I membrane proteins

  3. Sanitary conditions of a colony of urban feral cats (Felis catus Linnaeus, 1758 in a zoological garden of Rio de Janeiro, Brazil Condições sanitárias de uma colônia urbana de gatos (Felis catus Linnaeus, 1758 em um jardim zoológico do Rio de Janeiro, Brasil

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    Flavya Mendes-de-Almeida

    2004-10-01

    Full Text Available The colony of urban stray cats living in the Rio de Janeiro zoological garden was studied in order to develop a population and health control program. As many cats as possible were captured during two months (47 animals and were classified according to gender, age, weight and coat markings. They were submitted to a general health evaluation, examined for the presence of ectoparasites and sent to a surgical neutering program. All animals had a blood sample drawn for CBC, platelet count, heartworm and retroviruses detection. Capillary blood smears were made for hemoparasites detection. Coat marking and colors were tabby (59.7%, followed by solid black (17%; torbie (10.6%; bicolor (10.6% and harlequin (2.1%. The only ectoparasites found were fleas, which infested 28% of the animals. The hemoparasites found were Haemobartonella felis (38% and piroplasmas that could not be differentiated between Cytauxzoon spp. and Babesia spp. (47%. No cat was found infected by Dirofilaria immitis or FeLV (Feline Leukemia Virus, although FIV (Feline Immunodeficiency Virus antibodies could be detected (21%. There was no correlation between hemoparasites and FIV infections. The estimated total cat population (mark-recapture method was 59; 68% female and 32% male, suggesting that a neutering program is in fact needed.As condições sanitárias e composição populacional de uma colônia de gatos urbanos, errantes, habitantes do zoológico do Rio de Janeiro foram estudadas, objetivando-se um programa de controle populacional e sanitário. Capturou-se o maior número de indivíduos possível durante dois meses (47 animais. Os animais capturados foram examinados quanto ao gênero, idade, peso, pelagem, inspeção geral e presença de ectoparasitas e eram encaminhados a um programa de esterilização cirúrgica. Cada animal teve uma amostra de sangue colhida para realização de hemograma completo, plaquetometria, pesquisa de hemoparasitas e de retrovírus. As marca

  4. 'El Quijote' y el conocimiento de lo humano

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    Juan Ramón de la Fuente

    2005-12-01

    us with anxiety, even at the very fact of being alive, opens to a life composed of other imaginary experiences that fiction puts within our reach. For real life is not and never has been enough to satisfy all human yearnings, and many would find it difficult to achieve a genuine balance without that unfulfilled "love of the impossible" in their lives. Don Quixote's psychology rejects labels, as does any complex, multifaceted literary character. In the words of Carlos Fuentes, "Don Quixote, the madman, is mad not only for believing everything he has read, but also for believing, as knights errant do, that seeking justice is his duty, that attaining justice is possible". Don Quixote's madness is humanism at its best.

  5. Aspectos epidemiológicos da leishmaniose visceral canina no município de Pedro Leopoldo, Minas Gerais, 2003 Epidemiologic aspects of canine visceral leishmaniasis in Pedro Leopoldo district, Minas Gerais, 2003

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    L.A.B. Naveda

    2006-12-01

    Full Text Available Determinou-se a prevalência da leishmaniose visceral canina (LVC no município de Pedro Leopoldo, MG, 2003, por meio de inquérito soro-epidemiológico. Coletaram-se amostras de sangue de 2.185 cães e aplicou-se questionário semi-estruturado em cada residência. Os animais foram divididos em quatro grupos, sendo o grupo A constituído de 1240 cães das áreas urbana e rural; o grupo B de 705 cães de áreas em torno dos focos; o grupo C, de 134 cães, cujas amostras foram coletadas durante o dia da vacinação anti-rábica oficial; e o grupo D composto de 111 cães errantes. Os dados foram armazenados em banco de dados EPIINFO 6.04b. Os 36 cães positivos foram localizados espacialmente com auxílio de GPS (Global Positioning System, e o georreferenciamento realizado por meio do programa AUTOCAD 2000. A prevalência global da LVC foi de 1,4% e variou de 1,1% na área urbana e 4,2% na rural. Estes resultados permitiram concluir que Pedro Leopoldo, de acordo com a classificação oficial do Ministério da Saúde, é área silenciosa, receptiva e vulnerável para LVC. A distribuição espacial dos casos é diferenciada e requer medidas sanitárias de acordo com cada área de risco.The prevalence of canine visceral leishmaniasis (CVL in Pedro Leopoldo district, 2003 was evaluated. A serum-epidemic inquiry was accomplished by collecting blood samples of dogs and by applying a semi structured questionnaire, according to groups, in each visited residence: group A, constituted of 1240 dogs of the urban and rural areas; group B, constituted of 705 dogs sampled around the focuses; group C, constituted of 134 dogs, wich samples were collected during the canine/feline antirabic vaccination; and group D, constituted of 111 wandering dogs. The data were stored in the EPI INFO 6.04b database. Positive dogs were spatially located using GPS (Global Positioning System and the geographycal reference was made through the AUTOCAD 2000 program. The district global

  6. Effects of tourist visitation and supplementary feeding on fish assemblage composition on a tropical reef in the Southwestern Atlantic

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    Martina Di Iulio Ilarri

    2008-12-01

    ívoros, herbívoros errantes e herbívoros territoriais foram significativamente mais abundantes no período AT. O turismo em ambientes recifais é cada vez mais uma opção na geração de renda para diversas comunidades costeiras nos trópicos. Conseqüentemente, investigações mais detalhadas sobre as conseqüências dos vários componentes desta atividade sobre o sistema recifal são necessárias para subsidiar iniciativas de manejo e conservação.

  7. Dingle and de Sitter Against the Metaphysicians, or Two Ways to Keep Modern Cosmology Physical

    Science.gov (United States)

    Gale, George

    It would be hard to find two more radically different personalities than the irascible Herbert Dingle and the courtly Willem de Sitter. Yet, when it came to their philosophy of science, these two otherwise-so-different men were united against a common enemy, those they both called the "metaphysicians." Right from 1917, de Sitter attempted always to keep cosmology tightly bound to real observations made upon a real world. In Kosmos, written near the end of his life, he re-affirms most strongly his principle that "there is nothing an orthodox physicist abhors more than metaphysics." Dingle, for his part, accepts early on the positivist use of the verifiability principle to eliminate metaphysics from science, and continuously wields the principle as a weapon against those errant cosmologists who would sacrifice science for a sort of mysticism. Both men reject the strict and literal use of the term "universe," and for the same reasons: there is no observation, no verification, of statements containing that term. Both men reject the "cosmological principle" as Milne and others use it, on the grounds, as de Sitter puts it, that "we have . . . no means of communicating with other observers, situated on faraway stars." Eddington, although always closely associated with de Sitter personally, comes in for his own fine share of criticism. After de Sitter's death, Dingle carried on the battle alone, always on the bases that he and de Sitter had earlier established. The two peaks in Dingle's long struggle were the notorious 1937 controversy in the pages of Nature, a nasty dogfight which managed to involve almost every single important physicist in Britain; thirteen years later, the long war with the metaphysicians ended with the pyrrhic victory of Dingle's Royal Astronomical Society Presidential Address' invective against the latest and greatest metaphysical creation, Bondi's steady state universe theory. In the end, however, it would be a mistake to believe that the campaign

  8. Araneofauna de pomares de laranja Valência nos Vales do Caí e Taquari, Rio Grande do Sul, Brasil Araneofauna of Valência orange orchards at the Caí and Taquari Valleys, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Ana P. Ott

    Full Text Available Assembléias de aranhas da vegetação herbácea foram amostradas com rede-de-varredura em dois pomares de laranja doce (Citrus sinensis no sul do Brasil. Cada pomar amostrado é caracterizado por receber um diferente tipo de manejo: "tradicional" ou "ecológico". Adicionalmente, foi amostrada a assembléia de aranhas das laranjeiras do pomar com manejo "ecológico" através do uso de guarda-chuva japonês. No total foram coletadas 3.876 aranhas, 2.379 nas laranjeiras do pomar de manejo "ecológico" e 1.497 junto à vegetação herbácea de ambos pomares; foram registradas 99 espécies de 17 famílias de aranhas; Oxyopes salticus Hentz, 1845 (Oxyopidae foi a aranha mais abundante na vegetação herbácea e Sphecozone cristata Millidge, 1991 (Linyphiidae a mais abundante nas laranjeiras. Aranhas errantes foram mais abundantes em ambos tipos de vegetação. A araneofauna da vegetação herbácea nos pomares com diferentes manejos não apresentou diferenças significativas na diversidade (H'= 2,13 - "ecológico"; 2,24 - "tradicional"; a diversidade foi menor nas laranjeiras (H'=1,95. Em razão de terem sido utilizados diferentes métodos de coleta nas amostragens entre os microhabitats, o índice de Jaccard (17,5% indicou baixa similaridade entre as assembléias.Assemblages of spiders of the herbaceous vegetation were sampled by sweeping method in two sweet orange orchards (Citrus sinensis in the south of Brazil. Each sampled orchard is characterized by receiving a different handling type: "traditional" or "ecological". In addition it was sampled the assemblage of spiders of the orange trees of the orchard with the "ecological" handling with the beating method. A total of 3,876 spiders were collected, 2,379 in the orange trees and 1,497 in the herbaceous vegetation; 17 families and 99 species were registered; Oxyopes salticus Hentz, 1845 (Oxyopidae was the most abundant spider in herbaceous vegetation and Sphecozone cristata Millidge, 1991

  9. Le grand assemblage du panoptique planétaire. Un travail d’amateurs...

    Directory of Open Access Journals (Sweden)

    Daniel Thierry

    2014-04-01

    Full Text Available L’actualité photographique résulte d’une scénographie déclinée à partir d’une typologie de cadrages conventionnels au sein desquels évoluent des acteurs interchangeables. L’histoire du photojournalisme a constitué une forme de cadre canonique qui a défini l’expression de plusieurs générations de reporters sans véritable innovation. La massification des images engagée avec l’apparition de la télévision a conforté ces cadres auprès des publics. Le besoin croissant d’alimenter des flux d’images dématérialisées a accéléré les évolutions technologiques des supports et entraîné de fortes évolutions des pratiques de réceptions. L’attente se porte de plus en plus sur l’universalité d’une vision panoptique rendue familière par la multiplicité des canaux de réception. Partant de ce constat, nous mettons en évidence une transformation importante de la nature des sources d’images d’actualité qui présentent deux caractéristiques principales. Tout d’abord les évolutions technologiques des capteurs d’images rendent ceux-ci pratiquement omniprésents à chaque instant en tout point de la planète. Par suite, ce maillage planétaire de capteurs produit des images sans auteurs et sans intentionnalité qui s’inscrivent dans les cadres préétablis. Face à cette perte de signification de la part des producteurs d’images, les récepteurs de ces milliards d’images errantes disponibles sont invités à composer des usages nouveaux face à l’actualité qui alimente les écrans en réseau. Les scènes classiques du photojournalisme perdurent, mais c’est avant tout l’activité des récepteurs de ces matériaux bruts qui produit l’écriture de l’actualité selon leurs attentes singulières. Face aux états du monde, la question de l’historicité, de la véracité ou de la partialité de l’auteur fait place à des critères de célérité, de définition et de formats de fichiers qui

  10. Resección intestinal masiva: Proceso de adaptación nutricional Massive intestinal resection: Nutritional adaptation process

    Directory of Open Access Journals (Sweden)

    S. Leyva-Martínez

    2007-10-01

    Full Text Available Introducción: La resección masiva de intestino delgado (RMID con remanente inferior a los 60 cm de yeyuno ocasiona una grave depleción hidroelectrolítico-vitamínica y calórico-proteica. En espera de trasplante intestinal viable la mayoría de RMID dependen de la Nutrición Parenteral (NPT. Caso clínico: Varón de 32 años. RMID por traumatismo seccionante de la raíz de la arteria mesentérica superior. En primera intervención de urgencia : yeyunostomía con resección de I. Delgado, colon derecho y bazo. A los 6 meses: anastomosis yeyunocólica con remanente yeyunal de 12 cm y colecistectomía profiláctica. Actuación nutricional: 1ª fase.-Estabilización hemodinámica y estimulación enteral (6 meses: NPT + Nutrición Enteral con fórmula elemental + solución oral glucohidroelectrolítica (SOGH + 15 g/d de glutamina oral + omeprazol. Indicadores de progresión: bioquímica, balance I/P. 2ª fase.-Adaptación digestiva con integración del colon (8 meses: Sustitución de NPT por NP Periférica a tiempo parcial. Dieta culinaria progresiva asociada a polienzimático pancreático, omeprazol, SOGH, glutamina, fórmula elemental. Indicadores de progresión: bioquímica, diuresis, peso y deposiciones. 3ª fase. Autosuficiencia sin dependencia parenteral: Dieta oral libre fragmentada asociada a polienzimático pancreático, bebidas mineralizadas, complemento enteral de fórmula, suplementos orales de Ca y Mg, polivitamínico-mineral oral, vitamina B12 im/mensual. Situación actual (52 meses de evolución: Ligera ganancia ponderal, diuresis > litro/día, 2-3 deposiciones normales, sin signos clínicos de deficiencias y valores de micronutrientes en sangre normales. Conclusión: Prescindir de la NP en RMID es posible considerando, como en este caso, una edad y etiología no desfavorables, y la precoz aplicación de un protocolo de adaptación del remanente adecuado.Introduction: Massive small bowel resection (MSBR with a remnant jejunum

  11. Evaluación inmunotoxicológica de compuestos con potencial farmacológico empleando ratones como modelo experimental

    Directory of Open Access Journals (Sweden)

    Mariño Ramos Angélica

    2007-04-01

    ,
    así como parámetros funcionales enmarcados en la normalidad para cepas nativas, resulta de fundamental
    interés, ya que es este modelo el utilizado de forma rutinaria en la evaluación de las nuevas moléculas candidatas
    a compuesto activo. En este trabajo como molécula modelo se empleó la ciclosporina A (CSA, un reconocido fármaco inmusupresor empleado en diversos tipos de transplantes y como molécula blanco se evaluó la Pentamidina, cuyo potencial tóxico ha sido demostrado in vivo cuando enfermedades parasitarias en humanos han sido tratadas con este medicamento. Los fármacos fueron evaluados empleando dos cepas murinas como modelo experimental, siendo el bazo el órgano linfoide seleccionado para realizar el estudio, debido a la alta densidad de células linfoides y a su relativa fácil manipulación. Las subpoblaciones celulares de interés que se evaluaron en este órgano, fueron células T colaboradoras (CD4+, células T citotóxicas (CD8+, células B (CD19+ y monocitos y macrófagos (CD14+, las cuales fueron detectadas por medio de anticuerpos monoclonales específicos para los co-receptores de superficie a su vez acoplados a fluorocromos detectables por citometría de flujo. Los resultados permitieron concluir que hay diferencias significativas en la respuesta a los fármacos dependiente de la cepa siendo los esplenocitos CD8+ de los ratones BALB/c más susceptibles al efecto de la Pentamidina, mientras que las células CD19+ de los ratones ICR resultaron más sensibles al tratamiento con CSA. Proponemos que la metodología empleada en
    nuestro estudio sea implementada para monitorear el potencial inmunotóxico de múltiples fármacos, constituyéndose en una herramienta valiosa al momento de determinar la seguridad de compuestos con potencial
    farmacológico. El Departamento de Farmacia de la  Universidad Nacional de Colombia continuará liderando
    la investigación conducente al descubrimiento de nuevos fármacos más seguros

  12. Estudio comparativo de la patogenicidad y la antigenicidad de 6 cepas de Paracoccidioides brasiliensis Comparative study of pathogenicity and antigenicity of six Paracoccidioides brasiliensis strains

    Directory of Open Access Journals (Sweden)

    J.L. Finquelievich

    1993-12-01

    Full Text Available Fueron estudiadas en forma comparativa 6 cepas de P. brasiliensis con el propósito de determinar su patogenicidad para la rata y su antigenicidad. Las mismas fueron aisladas de : 1 biopsia de cuello uterino en 1989 (U, 2 biopsia de mucosa bucal en 1988 (V, 3 aspiración ósea en 1991 (63265, 4 testículo de cobayo 1984(C24, 5 punción-aspiración ganglionaren 1986 (G y 6 cepa proveniente de la Escola Paulista de Medicina (339. Se prepararon antigenos citoplasmáticos liofilizados de cada una de ellas, en la concentración final de 100 mg/ml y se realizaron pruebas de inmunodifusión frente a 6 sueros patrones positivos de ratas. En este ensayo todos los antígenos presentaron dos ó tres bandas de precipitación. Para estudiar el poder patógeno se inocularon, en total, 120 ratas Wistar, de ambos sexos de 200 g de peso, por via intracardíaca con suspensiones de la fase levaduriforme del P. brasiliensis, en concentraciones de 3x10(7 y 5x10(7 células/ml de cada cepa. Los animales que no murieron espontáneamente fueron sacrificados a los 14,28,42, 56 y 70 dias post-infección y se evaluaron los siguientes parámetros: A exámenes macro y microscópicos de pulmones, hígado, bazo y riñones; B cultivos de un pulmón y C prueba de inmunodifusión con antígeno homólogo. Se consideró además, el porcentaje de muertes espontáneas por cada cepa. Los resultados de estos estudios fueron los siguientes:No se observó relación entre la patogenicidad y la antigenicidad. La cepa más virulenta correspondió a un aislamiento reciente a partir de una forma juvenil grave y la más antigénica fue una cepa, morfológicamente atípica, que no provocó lesiones macroscópicas ni microscópicas en los órganos de las ratas.A comparative study of antigenicity and patho-genicity for rats of six Paracoccidioides brasiliensis strains was carried out. The antigenic capacity "in vitro" of cytoplasmic extract from each strain was determined by immuno-diffusion test

  13. High Energy Physics: Proceedings of the Fifth Latin American Symposium

    Science.gov (United States)

    Solano Salinas, C. J.; Pereyra Ravinez, O.; Ochoa Jiménez, R.; Masperi, Luis

    2006-04-01

    -Halpern operators / H. Blas. Is there really an entangled state for far away twin photons? / H. G. Valqui. Use of neural networks to classify cosmic-ray showers according to their Muon/EM ratio / H. Salazar and L. Villaseñor. [symbol] polarization in pp-->p[symbol]K+[symbol] at 27.5 GeV / J. Félix ... [et al.]. Definition of the polarization vector / V. M. Castillo-Vallejo and J. Félix. The MINOS experiment / M. Sanchez. Study of scintillating counters and their application to VO detector of ALICE / J. E. Ruiz and Tabasco. Data selection of [symbol] muon semileptonic decay in KTeV / R. A. Gomes. Chaotic properties of high energy cosmic rays / A. Ticona ... [et al.]. Energy spectrum of surviving protons / R. Calle ... [et al.]. Calculus of the ratio [symbol] in the K meson decay through the 331 model / J. C. Montero ... [et al.]. Use of a scintillator detector for luminosity measurements / G. Contreras, C. J. Solano Salinas and A. M. Gago. Simplified forms of a linear and exact set of equations for the gravitational field in the very early universe / E. Salinas -- Posters. Determination of the b-Mass using Renormalon Cancellation / C. Contreras. CP violation in B-->?K* decays: amplitudes, factorization and new physics / D. Gómez Dumm and A. Szynkman. Degeneracies in the measurement of neutrino oscillation parameters: problem and solution in neutrino factories / J. Jones and A. M. Gago. Revision of the neutrino oscillation probability in the supernovae / L. Aliaga and A. M. Gago. Consequences on the neutrino mixing matrix from two zero textures in the neutrino mass matrix / L. Stucchi, A. M. Gago and V. Gupta. Expected flux of high energy neutrinos from observed active galactic nuclei / J. L. Bazo and A. M. Gago. Masperi's Quasispin model of the scalar field [symbol] theory with soliton solutions / M. Agüero, G. Frias and F. Ongay. Nonstandard CP violation in B-->[symbol] decays / A. Szynkman. Spinor realization of the Skyrme Model / R. Ochoa Jimenez and Yu. P. Rybakov.

  14. Glucogenosis tipo I: reporte de dos casos en dos hermanos de Cartagena de Indias-Colombia

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    Alvear-Sedán Ciro

    2011-09-01

    Full Text Available CASO CLÍNICO: # 1. Producto del primer embarazo de padres no consanguíneos, con lactancia hasta los dos años. A los 18 meses deedad presentó distensión abdominal, hepatomegalia difusa no dolorosa, diarrea de mes y medio, debilidad generalizada, edemaprogresivo en cara y pies, anasarca y anemia. Vesícula, bazo y riñones normales y examen neurológico sin alteraciones. Nopresentó hipoglucemia, ácido láctico normal. Pruebas hepáticas alteradas; colesterol, triglicéridos y ácido úrico en el límitesuperior normal. Nunca convulsionó y los síntomas remitieron a los cinco años de edad. Actualmente tiene 14 años y su examenfísico es normal, con talla y peso acorde a la edad. # 2. Producto del segundo embarazo, hermano del anterior, con lactancia hastalos dos años. A los 11 meses de edad presentó cianosis generalizada sin otra sintomatología. Se descartó patología cardiaca. A losdos años presentó cuadro de un mes con distensión abdominal, pérdida de peso, astenia, adinamia, palidez generalizada,hepatomegalia, ascitis, hiperbilirrubinemia mixta con predominio de la directa. Presentó anemia. leucocitos, plaquetas, TP, TPT,proteinograma y glucemia normales. Serologías para hepatitis B negativa. Tamizaje metabólico normal. A los cuatro años presentócrisis tónico-clónica generalizada asociada a vómitos y hepatomegalia homogénea de 5 cm. TAC normal. Edad ósea retardada dedos y medio años, glucemia en ayunas de 31 mg/dL, colesterol, triglicéridos, ácido urico, LDH, AST y FAL elevados. Recibía dieta queincluía maizena antes de acostarse. A los cinco años, biopsia hepática: PAS positivo con cambios compatibles con glicogenosis tipoI. Presentó hematuria persistente, con períodos de hipoglucemia intermitente asintomática. Presentó nefromegalia. A partir de los9 años ha disminuido la hepatomegalia y nefromegalia; tuvo fractura brazo izquierdo con mala consolidación. Actualmente tiene11 años, talla baja de 120 cm

  15. Range expansion of Oligoryzomys longicaudatus (Rodentia, Sigmodontinae in Patagonian Chile, and first record of Hantavirus in the region Ampliación del rango de distribución de Oligoryzomys longicaudatus (Rodentia, Sigmodontinae en la Patagonia de Chile y primer registro de Hantavirus en la región

    Directory of Open Access Journals (Sweden)

    SEBASTIÁN BELMAR-LUCERO

    2009-06-01

    úan entre 46-70 cromosomas. En Chile se reconocen dos especies, Oligoryzomys longicaudatus (Bennet, 1832; "colilargo"; 2n = 56, desde los 27° S hasta aproximadamente 51° S, y Oligoryzomys magellanicus (Bennet, 1836; 2n = 54, al sur de los 51 ° S en la región Patagónica de Chile y Argentina. Como parte de una investigación en curso en la Patagonia sur de Chile, reportamos los resultados de muéstreos de pequeños mamíferos en seis localidades. Cariotipamos 28 especímenes y secuenciamos la región hipervariable I del mtDNA en 22 individuos, alineando estas secuencias con una filogenia de O. longicaudatus en desarrollo. Adicionalmente evaluamos la serología y la presencia de carga viral en todos los especímenes capturados con el objeto de detectar la presencia de anticuerpos anti-Andesvirus (ANDV mediante Strip Immunoblot Assay (SIA, y de genoma viral mediante RT-PCR. Los resultados muestran consistentemente que el cariotipo de los especímenes de la Patagonia sur de Chile es 2n = 56, similar al de O. longicaudatus, y que los individuos de esta región no se diferencian filogenéticamente de aquellos del norte del rango de distribución de esta especie. Adicionalmente, los análisis serológicos demostraron la presencia de anticuerpos IgG anti-ANDV y de genoma viral en corazón, riñon, bazo y pulmones de un espécimen de Oligoryzomys de la localidad de Fuerte Bulnes en la Región de Magallanes. Concluimos que todos los especímenes capturados al sur de los 51° S corresponden a Oligoryzomys longicaudatus, expandiendo así el rango de distribución de esta especie hasta al menos 55° S. Los resultados también extienden la distribución de la cepa Andes de Hantavirus al extremo sur de la Patagonia.

  16. Influência dos exercícios físicos de baixa e alta intensidade sobre o limiar de hipernocicepção e outros parâmetros em ratos Influencia de los ejercicios físicos de baja y alta intensidad sobre el límite de hipernocicepción y otros parámetros en ratones Influence of low and high intensity physical exercise on hypernociception threshold and other parameters of rats

    Directory of Open Access Journals (Sweden)

    Ademir da Costa Lana

    2006-10-01

    alta intensidad sobre la hipernocicepción, además de evaluar la masa corporal y el peso relativo de algunos órganos de ratones. Para esto, se han utilizado ratones machos, adultos, de linaje Wistar, los que fueron sometidos (grupo entrenado o no (grupo no entrenado a ejercicios en cinta ergo métrica. La inflamación aguda fue inducida por la inyección de carragenina 0,5% en el cóccix de la pata posterior izquierda de los ratones y la nocicepción fue medida por medio del test plantar antes y pos 1, 2, 3, 4, 6, 8 y 24 horas. Al final de las evaluaciones los ratones fueron sometidos a anestesia profunda, incluso la eutanasia, para colectar y pesar las glándulas adrenales, corazón, bazo y riñones y posterior estudio anatomopatológico de estos tejidos. El análisis estadístico de los resultados mostró un aumento significante (P Physical exercise practice is an important habit to maintain the physical and emotional well-being of those who regularly adopt it, and can bring great benefits to health. However, depending on the type, intensity, frequency and duration of the exercises, they can also do a certain degree of harm to the organism. As a benefit, the role of physical exercise is described in the specific and non-specific immune function and, in the latter, the inflammatory process stands out. Therefore, the purpose of this study was to show the effects of low and high intensity physical exercises on hypernociception, and to evaluate the body mass and the relative weight of some organs in rats. For the study, male adult Wistar rats were used and submitted (trained group or not submitted (non-trained group to physical exercises on an ergometric treadmill. The acute inflammation was induced by an injection of carrageenin-0.5% into the plantar tissue of the left hind paw of each rat and the nociception was measured by the plantar test before and after 1, 2, 3, 4, 6, 8 and 24 hours. At the end of the evaluations, the rats were submitted to deep anesthesia until

  17. Papel de las moléculas de adhesión ICAM-1 Y LFA-1 en la patogénesis de la Paracoccidioidomicosis pulmonar experimental

    Directory of Open Access Journals (Sweden)

    Luz Elena Cano

    2000-02-01

    style="font-size: 4.5pt; font-family: Arial">6 conidias de P. brasiliensis, cepa ATCC 60855 o con PBS (grupo control. Para determinar la respuesta inflamatoria y la expresión de ICAM-1 y LFA-1 a nivel pulmonar los animales son sacrificados a los 0, 1, 2, 3, 4, 7, 14 y 28 días post-infección para estudiar en ellos:

    a La celularidad del lavado broncoalveolar (LBA (# total de células/animal y % de cada tipo celular y b la detección por inmunohistoquímica de la expresión de ICAM-1 y LFA-1 en los pulmones de ambos grupos de animales. Para evaluar el papel in vivo del ICAM-1 y LFA-1 en el control de la infección los animales infectados y no infectados serán tratados con anticuerpos monoclonales anti-ICAM-1 y anti-LFA-1. Se registrará diariamente el numero de muertes de cada grupo, por un periodo de cuatro meses y se determinará la diseminación extrapulmonar del hongo mediante el cultivo de órganos (hígado,

    bazo y pulmón.

    Resultados: se obtuvieron un total de 112 LBA distribuidos en 8 grupos con 14 muestras cada uno (8 infectados y 6 controles. El grupo control presento una baja celularidad (0.13 ± 0.032 x 106 células sin existir diferencia significativa entre los diferentes periodos estudiados. Estos LBA presentaron un alto porcentaje de macrófagos ( 97.0 ± 5.4 % con escasos PMN (2.4 Actualización clínica de las manifestaciones perictales e interictales epilépticas

    Directory of Open Access Journals (Sweden)

    Roberto Anselmo Ramos Valverde

    2015-06-01

    ógicos. - Estado ictal: Puede iniciarse primariamente con una alteración de la conciencia o ir precedido por síntomas de trastornos focales casi siempre del lóbulo temporal (crisis uncinadas. Se caracterizan por movimientos de búsqueda de la cabeza, los ojos y otras partes del cuerpo, crepitación de los labios, movimientos masticatorios o deglutorios, salivación abundante, desorientado parcialmente alopsíquica, pueden vagar sin finalidad, suelen decir frases inteligibles, aparecer automatismos complejos, tienden a realizar actos sofisticados de conducta aparentemente intencionada que duran horas o días. Pueden ejecutarse discursos, conciertos de pianos y fugas epilépticas que duran horas o días, a veces se producen accidentes o crímenes. - Estado postictal: Sigue a una o varias crisis (que pueden ocurrir durante el sueño. El paciente despierta confundido, desorientado, refunfuñando cosas incoherentes revolviendo sus ropas, aparecen crisis de excitación que duran minutos, agitación extrema, ideación paranoide, alucinaciones, ilusiones, que conllevan a la agresividad, atacan a los demás, vagan errantes y se comportan de forma peligrosa para él y para los demás, presentan notable alteración de la conciencia, sin deterioro motor o lingüístico, existe amnesia total para el periodo, remite total y bruscamente. - Estados interictales: Maniacos: se presentan durante horas o semanas, son clínicamente indistinguibles de un episodio hipertímico. Disfóricos: son frecuentes, súbitos, propician la violencia, pueden precipitarse por el consumo de alcohol. Depresivos: tendencia súbita a la depresión de variada intensidad, con marcada impulsividad que posibilita intento suicida con alto riesgo de consumar el suicidio. Estados psicóticos breves (psicosis de tellenbach: son polimorfos, fugases, poseen riqueza delirante y alucinatoria visual y auditiva. Mixtos: combina hipertimia, disforia, depresión, alucinaciones y delirios. Trastorno de la personalidad: lo caracteriza

  18. Seroepidemiology of leptospirosis in pet dogs in the urban area of the municipality of Jataizinho, ParanáSoroepidemiologia da leptospirose em cães domiciliados na área urbana do município de Jataizinho, Paraná

    Directory of Open Access Journals (Sweden)

    Jean Carlos Alves Barbara

    2012-02-01

    presentes na região e sugerir os reservatórios envolvidos nesta importante zoonose. O objetivo deste trabalho foi determinar a prevalência de anticorpos antileptospiras em 653 cães de 369 domicílios distribuídos na área urbana do município de Jataizinho, PR, e estudar variáveis associadas ao risco de infecção por leptospiras nesses animais. As amostras de soro foram submetida a prova de soroaglutinação microscópica (SAM frente a 23 sorovares de leptospiras patogênicas. Das 132 (20,21% amostras de cães reagentes, 15 (11,36% reagiram para mais de um sorovar, não sendo possível determinar o sorovar mais provável, e das 117 (88,73% que reagiram para um sorovar somente, o sorovar Canicola foi considerado o mais provável em 89 (76,07%. Variáveis associadas ao risco da doença foram investigadas através de um questionário epidemiológico aplicado a cada proprietário e os dados obtidos foram analisados pelo programa estatístico EpiInfo. As variáveis significativas (p ? 0,05 associadas à soropositividade para leptospirose nos cães domiciliados em área urbana do município de Jataizinho, PR, foram: visualizar ratos no ambiente familiar, animal adulto ou idoso, livre acesso do cão à rua e contato com cães errantes. Os resultados indicam uma alta prevalência de cães domiciliados em área urbana de Jataizinho, PR, com anticorpos antileptospiras e sugerem a necessidade de conscientizar a população do município sobre a vacinação dos cães, assim como, o papel epidemiológico do cão na leptospirose urbana.

  19. Juvenile Cosmology; Or Richard Powers’ Post-Global Doughnut

    Directory of Open Access Journals (Sweden)

    Judith Roof

    2010-02-01

    Full Text Available Le roman de Richard Powers, Operation Wandering Soul (1993, présente le lien subtil qui associe un mondialisme déjà usé et vieillissant à l’enfant perçu comme catégorie dominante. Comme les faces serpentines d’un ruban de Möbius lové autour de l’illimité et de l’intemporel, le texte, tendu entre ses deux infinis – l’univers et l’enfant – révise la portée, la conception, la structure et le style du genre romanesque. Délaissant Aristote pour Einstein, Operation Wandering Soul se place sur le terrain de la cosmologie. Le récit, qui rassemble la kyrielle des grands ralliements juvéniles et leurs vains pèlerinages, concentre l’espace-temps dans une présentation qui évoque la « somme des histoires » de Richard Feynman. La contraction de l’espace-temps opérée par le roman ne fait pas de celui-ci un hymne simpliste au global (catégorie déjà aussi datée que celle des malheureux vétérans du Vietnam, mais capte au contraire la conscience grandissante d’une existence sans origine qui s’étend à perte de vue au-delà de ses coordonnées supposées. Le roman s’enroule sur lui-même tout en s’épanchant au dehors, boucle ses cadres et ses détours tout en desserrant leur emprise. Il fait tourner la roue de ses récits comme des planètes en rotation, la ronde d’un système solaire, le tourbillon d’une galaxie. La conscience que présente Operation Wandering Soul ne se résume donc pas au seul point de vue de l’âme errante qu’est le personnage de Kraft, mais consiste en la somme de tous les temps et de tous les lieux, de leurs strates accumulées comme une conscience en acte, complexe et tissée de réseaux, qui n’appartient à personne et est partagée par tous. Cette accumulation organise le jeu des perspectives multiples qui instaurent l’acte de lecture et sont instaurées par lui. À cet égard, lire constitue ici une physique des oubliés.Richard Powers’ novel Operation Wandering

  1. Anestesia epidural cranial com lidocaína e morfina para campanhas de castração em cães Cranial epidural anesthesia with lidocaine and morphine for sterilization campaign in dogs

    Directory of Open Access Journals (Sweden)

    Renato Batista Tamanho

    2010-02-01

    Full Text Available A castração de machos e fêmeas tem sido preconizada como a principal técnica para redução do grande número de cães errantes. No entanto, vários são os entraves com relação à escolha do melhor protocolo anestésico, em relação à eficácia, segurança e redução de custos. Objetivou-se, com este trabalho, avaliar os efeitos cardiorrespiratórios, hemogasométricos e analgésicos da utilização de lidocaína em um volume maior, associada à morfina, pela via epidural em cadelas submetidas à ovariosalpingohisterectomia (OSH, com ou sem suplementação de oxigênio. Utilizaram-se 12 cadelas, com peso médio de 11,5±3,7kg e idade de um a quatro anos. Os animais receberam como medicação pré-anestésica (MPA acepromazina (0,1mg kg-1 e meperidina (5mg kg-1, pela via intramuscular. Após 15 minutos, administrou-se tiopental (10mg kg-1, por via intravenosa, seguido de intubação endotraqueal. Nesse momento, os animais foram alocados em dois grupos: o grupo GCO (com oxigênio, n=06 recebeu suplementação de oxigênio 100% e o grupo GSO (sem oxigênio, n=06 permaneceu intubado sem suplementação de oxigênio. Após a intubação, foi administrada, pela via epidural, em ambos os grupos, morfina (0,1mg kg-1 em volume final ajustado para 1mL 3,0kg-1 de peso com lidocaína 2% sem vasoconstritor. Imediatamente após a anestesia epidural, os animais foram posicionados em decúbito dorsal com a cabeça no mesmo plano do corpo, e iniciou-se o procedimento cirúrgico, o qual foi padronizado em 30 minutos. Em ambos os grupos, foi possível realizar a cirurgia sem a necessidade de complementação analgésica e sem resposta de dor. A pressão arterial média (PAM foi menor no GSO em todos os momentos em comparação ao basal. No GCO, a PAM foi menor após MPA e após epidural. Houve redução da f de M1 até M6 no GSO. A SaO2 e PaO2 foram maiores no GCO em comparação ao GSO. O pH foi menor no GCO 15 minutos após MPA até 40 minutos ap