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Sample records for basso beattie bresnahan

  1. Adaptation of the Basso-Beattie-Bresnahan locomotor rating scale for use in a clinical model of spinal cord injury in dogs.

    Science.gov (United States)

    Song, Rachel B; Basso, D Michele; da Costa, Ronaldo C; Fisher, Lesley C; Mo, Xiaokui; Moore, Sarah A

    2016-08-01

    Naturally occurring acute spinal cord injury (SCI) in pet dogs provides an important clinical animal model through which to confirm and extend findings from rodent studies; however, validated quantitative outcome measures for dogs are limited. We adapted the Basso Beattie Bresnahan (BBB) scale for use in a clinical dog model of acute thoracolumbar SCI. Based on observation of normal dogs, modifications were made to account for species differences in locomotion. Assessments of paw and tail position, and trunk stability were modified to produce a 19 point scale suitable for use in dogs, termed the canine BBB scale (cBBB). Pet dogs with naturally occurring acute SCI were assigned cBBB scores at 3, 10 and 30days after laminectomy. Scores assigned via the cBBB were stable across testing sessions in normal dogs but increased significantly between days 3 and 30 in SCI-affected dogs (p=0.0003). The scale was highly responsive to changes in locomotor recovery over a 30day period, with a standardized response mean of 1.34. Concurrent validity was good, with strong correlations observed between the cBBB and two other locomotor scales, the OSCIS (r=0.94; pin canine clinical translational models of SCI. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. BAMOS: A recording application for BAsso MOuse scale of locomotion in experimental models of spinal cord injury.

    Science.gov (United States)

    Gómez, Alberto; Nieto-Díaz, Manuel; Del Águila, Ángela; Arias, Enrique

    2018-05-01

    Transparency in science is increasingly a hot topic. Scientists are required to show not only results but also evidence of how they have achieved these results. In experimental studies of spinal cord injury, there are a number of standardized tests, such as the Basso-Beattie-Bresnahan locomotor rating scale for rats and Basso Mouse Scale for mice, which researchers use to study the pathophysiology of spinal cord injury and to evaluate the effects of experimental therapies. Although the standardized data from the Basso-Beattie-Bresnahan locomotor rating scale and the Basso Mouse Scale are particularly suited for storage and sharing in databases, systems of data acquisition and repositories are still lacking. To the best of our knowledge, both tests are usually conducted manually, with the data being recorded on a paper form, which may be documented with video recordings, before the data is transferred to a spreadsheet for analysis. The data thus obtained is used to compute global scores, which is the information that usually appears in publications, with a wealth of information being omitted. This information may be relevant to understand locomotion deficits or recovery, or even important aspects of the treatment effects. Therefore, this paper presents a mobile application to record and share Basso Mouse Scale tests, meeting the following criteria: i) user-friendly; ii) few hardware requirements (only a smartphone or tablet with a camera running under Android Operating System); and iii) based on open source software such as SQLite, XML, Java, Android Studio and Android SDK. The BAMOS app can be downloaded and installed from the Google Market repository and the app code is available at the GitHub repository. The BAMOS app demonstrates that mobile technology constitutes an opportunity to develop tools for aiding spinal cord injury scientists in recording and sharing experimental data. Copyright © 2018 Elsevier Ltd. All rights reserved.

  3. The Irvine, Beatties, and Bresnahan (IBB) Forelimb Recovery Scale: An Assessment of Reliability and Validity

    Science.gov (United States)

    Irvine, Karen-Amanda; Ferguson, Adam R.; Mitchell, Kathleen D.; Beattie, Stephanie B.; Lin, Amity; Stuck, Ellen D.; Huie, J. Russell; Nielson, Jessica L.; Talbott, Jason F.; Inoue, Tomoo; Beattie, Michael S.; Bresnahan, Jacqueline C.

    2014-01-01

    The IBB scale is a recently developed forelimb scale for the assessment of fine control of the forelimb and digits after cervical spinal cord injury [SCI; (1)]. The present paper describes the assessment of inter-rater reliability and face, concurrent and construct validity of this scale following SCI. It demonstrates that the IBB is a reliable and valid scale that is sensitive to severity of SCI and to recovery over time. In addition, the IBB correlates with other outcome measures and is highly predictive of biological measures of tissue pathology. Multivariate analysis using principal component analysis (PCA) demonstrates that the IBB is highly predictive of the syndromic outcome after SCI (2), and is among the best predictors of bio-behavioral function, based on strong construct validity. Altogether, the data suggest that the IBB, especially in concert with other measures, is a reliable and valid tool for assessing neurological deficits in fine motor control of the distal forelimb, and represents a powerful addition to multivariate outcome batteries aimed at documenting recovery of function after cervical SCI in rats. PMID:25071704

  4. Salvia miltiorrhiza aqueous root extract plays an important role in ...

    African Journals Online (AJOL)

    and treated. Aqueous root extract of S. miltiorrhiza was introduced intraperitoneally to the treated group. Basso, Beattie and Bresnahan rating scale (BBB) was used to ... extract has therapeutic potential for the treatment of neuronal degeneration following SCI. ..... effects of Lycium barbarum Lynn on protecting retinal.

  5. Basso continuo sources from the Dutch Republic c. 1620-c1790

    NARCIS (Netherlands)

    Cok, Kathryn Meriel

    2011-01-01

    The results presented in this dissertation demonstrate the generous contribution that the Dutch Republic has made to the genre of basso continuo, including a survey of twenty-six Dutch sources from the 17th and 18th centuries. Focus has been made on the written record of the practice in the Dutch

  6. The Effects of rhBMP-2 Used for Spinal Fusion on Spinal Cord Pathology After Traumatic Injury

    Science.gov (United States)

    2009-07-29

    1219-1224; discussion 1225. Basso DM , Beattie MS, Bresnahan JC (1995) A sensitive and reliable locomotor rating scale for open field testing in rats...usage of rhBMP-2 in the anterior cervical spine. Spine 31:2813-2819. Stuesse SL, Crisp T, McBurney DL, Schechter JB, Lovell JA, Cruce WL (2001...250-256. Stuesse SL, Crisp T, McBurney DL, Schechter JB, Lovell JA, Cruce WL (2001) Neuropathic pain in aged rats: behavioral responses and

  7. The Blood Testis Barrier and Male Sexual Dysfunction following Spinal Cord Injury

    Science.gov (United States)

    2015-10-01

    non-invasive, Basso, Beattie, Bresnahan (BBB) open field locomotor test beginning on day 1 post-SCI. Briefly, this test scores rat hind limb...barrier integrity and enhances locomotor function in rats when given early following injury. During this third year, we have completed all planned...these SCI-induced pathologies within the testes long after cessation of licofelone treatment. Our results to date, are intriguing and suggest that SCI

  8. 1993 recreational vehicle (RV) park census in Beatty and Pahrump, Nevada

    International Nuclear Information System (INIS)

    Levy, L.E.; Housel, M.D.

    1994-01-01

    This paper reports on the second annual study of seasonal nonpermanent residents in the towns of Beatty and Pahrump in southern Nye County, Nevada, situs county of the Yucca Mountain Site Characterization Project. The study used a census of recreational vehicle (RV) park managers to enumerate and characterize in demographic terms nonpermanent residents staying in RV parks. The questionnaire sought information from RV park managers which ordinarily would come from a household survey. The main objective was to study open-quotes snowbirdsclose quotes, the households of older couples who stay for a month or more each winter. The findings suggest that snowbirds are a majority of the seasonal influx of nonpermanent residents to RV parks in Pahrump. In contrast, a group called open-quotes seasonal travelersclose quotes, similar demographically but who stay less than a month, dominate the seasonal nonpermanent population in Beatty's RV parks. The study also tentatively identified the seasonality of nonpermanent resident occupancy. Because only RV parks were contacted, the study left unanswered the question of how many snowbirds live in other types of accommodations in Beatty and Pahrump

  9. The ground beetles (Coleoptera, Carabidae of “Bosco Palli”, a relict Turkey oak wood in Basso Monferrato (Piedmont, Italy

    Directory of Open Access Journals (Sweden)

    Allegro G

    2016-12-01

    Full Text Available The Carabid fauna of “Bosco Palli”, a relict Turkey oak wood in the hilly area of Basso Monferrato, is described. This wood covers an area of about 50 hectares divided in two separate core areas and is almost entirely surrounded by agricultural crops. A total of 25 Carabid species were recorded, of which only 11 are present in the central core areas and 23 in the peripheral ecotone areas. There are only very few species with strict forest attitude, but a prosperous population of Carabus italicus was recorded, located in a peripheral portion of the forest on moist and swampy soil. The poorness of this fauna and the scarcity of specialized forest species may be a consequence of the limited area of the wood, its fragmentation, the total isolation in an agricultural context and the repeated coppicing carried out up to about half of the past century.

  10. Feasibility of Diffusion Tensor Imaging for Assessing Functional Recovery in Rats with Olfactory Ensheathing Cell Transplantation After Contusive Spinal Cord Injury (SCI).

    Science.gov (United States)

    Gu, Mengchao; Gao, Zhengchao; Li, Xiaohui; Zhao, Feng; Guo, Lei; Liu, Jiantao; He, Xijing

    2017-06-17

    BACKGROUND Olfactory ensheathing cell transplantation is a promising treatment for spinal cord injury. Diffusion tensor imaging has been applied to assess various kinds of spinal cord injury. However, it has rarely been used to evaluate the beneficial effects of olfactory ensheathing cell transplantation. This study aimed to explore the feasibility of diffusion tensor imaging in the evaluation of functional recovery in rats with olfactory ensheathing cell transplantation after contusive spinal cord injury. MATERIAL AND METHODS Immunofluorescence staining was performed to determine the purity of olfactory ensheathing cells. Rats received cell transplantation at week 1 after injury. Basso, Beattie, and Bresnahan score was used to assess the functional recovery. Magnetic resonance imaging was applied weekly, including diffusion tensor imaging. Diffusion tensor tractography was reconstructed to visualize the repair process. RESULTS The results showed that olfactory ensheathing cell transplantation increased the functional and histological recovery and restrained the secondary injury process after the initial spinal cord injury. The fractional anisotropy values in rats with cell transplantation were significantly higher than those in the control group, while the apparent diffusion coefficient values were significantly lower. Basso, Beattie, and Bresnahan score was positively and linearly correlated with fractional anisotropy value, and it was negatively and linearly correlated with apparent diffusion coefficient value. CONCLUSIONS These findings suggest that diffusion tensor imaging parameters are sensitive biomarker indices for olfactory ensheathing cell transplantation interventions, and diffusion tensor imaging scan can reflect the functional recovery promoted by the olfactory ensheathing cell transplantation after contusive spinal cord injury.

  11. Effect of intravenous transplantation of bone marrow mesenchymal stem cells on neurotransmitters and synapsins in rats with spinal cord injury

    Science.gov (United States)

    Chen, Shaoqiang; Wu, Bilian; Lin, Jianhua

    2012-01-01

    Bone marrow mesenchymal stem cells were isolated, purified and cultured in vitro by Percoll density gradient centrifugation combined with the cell adherence method. Passages 3–5 bone marrow mesenchymal stem cells were transplanted into rats with traumatic spinal cord injury via the caudal vein. Basso-Beattie-Bresnahan scores indicate that neurological function of experimental rats was significantly improved over transplantation time (1–5 weeks). Expressions of choline acetyltransferase, glutamic acid decarboxylase and synapsins in the damaged spinal cord of rats was significantly increased after transplantation, determined by immunofluorescence staining and laser confocal scanning microscopy. Bone marrow mesenchymal stem cells that had migrated into the damaged area of rats in the experimental group began to express choline acetyltransferase, glutamic acid decarboxylase and synapsins, 3 weeks after transplantation. The Basso-Beattie- Bresnahan scores positively correlated with expression of choline acetyltransferase and synapsins. Experimental findings indicate that intravenously transplanted bone marrow mesenchymal stem cells traverse into the damaged spinal cord of rats, promote expression of choline acetyltransferase, glutamic acid decarboxylase and synapsins, and improve nerve function in rats with spinal cord injury. PMID:25657678

  12. Standardization of a spinal cord lesion model and neurologic evaluation using mice

    Science.gov (United States)

    Borges, Paulo Alvim; Cristante, Alexandre Fogaça; de Barros-Filho, Tarcísio Eloy Pessoa; Natalino, Renato Jose Mendonça; dos Santos, Gustavo Bispo; Marcon, Raphael Marcus

    2018-01-01

    OBJECTIVE: To standardize a spinal cord lesion mouse model. METHODS: Thirty BALB/c mice were divided into five groups: four experimental groups and one control group (sham). The experimental groups were subjected to spinal cord lesion by a weight drop from different heights after laminectomy whereas the sham group only underwent laminectomy. Mice were observed for six weeks, and functional behavior scales were applied. The mice were then euthanized, and histological investigations were performed to confirm and score spinal cord lesion. The findings were evaluated to prove whether the method of administering spinal cord lesion was effective and different among the groups. Additionally, we correlated the results of the functional scales with the results from the histology evaluations to identify which scale is more reliable. RESULTS: One mouse presented autophagia, and six mice died during the experiment. Because four of the mice that died were in Group 5, Group 5 was excluded from the study. All the functional scales assessed proved to be significantly different from each other, and mice presented functional evolution during the experiment. Spinal cord lesion was confirmed by histology, and the results showed a high correlation between the Basso, Beattie, Bresnahan Locomotor Rating Scale and the Basso Mouse Scale. The mouse function scale showed a moderate to high correlation with the histological findings, and the horizontal ladder test had a high correlation with neurologic degeneration but no correlation with the other histological parameters evaluated. CONCLUSION: This spinal cord lesion mouse model proved to be effective and reliable with exception of lesions caused by a 10-g drop from 50 mm, which resulted in unacceptable mortality. The Basso, Beattie, Bresnahan Locomotor Rating Scale and Basso Mouse Scale are the most reliable functional assessments, and but the horizontal ladder test is not recommended. PMID:29561931

  13. Vadose-zone instrumentation in coarse alluvial deposits of the Amargosa Desert near Beatty, Nevada

    International Nuclear Information System (INIS)

    Morgan, D.S.; Fischer, J.M.

    1984-01-01

    A vadose-zone monitoring shaft near Beatty, NV, is 1.52 m in diameter and penetrates nearly 14 m of unsaturated fluvial sediments. These sediments are comprised of silty sand, coarse sandy gravel, and poorly cemented sand, with gravel and occasional cobbles and boulders. Thirty-three lateral ports at 11 levels between 3 and 13 m deep allow access to undisturbed sediments outside the vertical shaft. The prefabricated metal shaft was emplaced in a 2.44-m-diameter hole excavated by using a crane drill with bucket and flight augers. Laboratory-calibrated thermocouple-psychrometers are being used to measure soil-matrix potential. A method of installing the phychrometers was developed which will allow their retrieval, after extended periods in the soil, for cleaning, recalibration, and reinstallation. Primary access holes 2.5 cm in diameter are drilled laterally outward from the monitoring shaft to a distance of approximately 4 m. The psychrometer is then inserted into the primary access hole and sealed into a smaller diameter boring in the undisturbed material at the outer end of the primary access hole. Data are collected and stored by a programmable measurement-control and data-logger system powered by photovoltaic cells. Magnetic-tape data storage is used to back up daily data retrieval via telecommunication with the project headquarters in Carson City, Nev., 520 km north of the study

  14. Assessment of the neuroprotective effects of Lavandula angustifolia extract on the contusive model of spinal cord injury in Wistar rats

    Directory of Open Access Journals (Sweden)

    Gholamreza eKaka

    2016-02-01

    Full Text Available IntroductionSpinal cord injury (SCI involves a primary trauma and secondary cellular processes that can lead to severe damage to the nervous system, resulting in long-term spinal deficits. At the cellular level, SCI causes astrogliosis, of which glial fibrillary acidic protein (GFAP is a major index. ObjectiveThe aim of this study was to investigate the neuroprotective effects of Lavandula angustifolia (Lav on the repair of spinal cord injuries in Wistar rats.Materials and MethodsForty-five female rats were randomly divided into six groups of seven rats each: the intact, sham, control (SCI, Lav 100, Lav 200, and Lav 400 groups. Every week after SCI onset, all animals were evaluated for behavior outcomes by the Basso, Beattie, and Bresnahan (BBB score. H&E staining was performed to examine the lesions post-injury. GFAP expression was assessed for astrogliosis. Somatosensory evoked potential (SEP testing was performed to detect the recovery of neural conduction.Results BBB scores were significantly increased and delayed responses on sensory tests were significantly decreased in the Lav 200 and Lav 400 groups compared to the control group. The greatest decrease of GFAP was evident in the Lav 200 and Lav 400 groups. EMG results showed significant improvement in the hindlimbs in the Lav 200 and Lav 400 groups compared to the control group. Cavity areas significantly decreased and the number of ventral motor neurons significantly increased in the Lav 200 and Lav 400 groups.ConclusionLav at doses of 200 mg/kg and 400 mg/kg can promote structural and functional recovery after SCI. The neuroprotective effects of L. angustifolia can lead to improvement in the contusive model of spinal cord injury in Wistar rats.Keywords Spinal cord injury (SCI; Lavandula angustifolia; neuroprotection; Basso, Beattie, and Bresnahan (BBB; glial fibrillary acidic protein (GFAP; somatosensory evoked potential (SEP

  15. Borax partially prevents neurologic disability and oxidative stress in experimental spinal cord ischemia/reperfusion injury.

    Science.gov (United States)

    Koc, Emine Rabia; Gökce, Emre Cemal; Sönmez, Mehmet Akif; Namuslu, Mehmet; Gökce, Aysun; Bodur, A Said

    2015-01-01

    The aim of this study is to investigate the potential effects of borax on ischemia/reperfusion injury of the rat spinal cord. Twenty-one Wistar albino rats were divided into 3 groups: sham (no ischemia/reperfusion), ischemia/reperfusion, and borax (ischemia/reperfusion + borax); each group was consist of 7 animals. Infrarenal aortic cross clamp was applied for 30 minutes to generate spinal cord ischemia. Animals were evaluated functionally with the Basso, Beattie, and Bresnahan scoring system and inclined-plane test. The spinal cord tissue samples were harvested to analyze tissue concentrations of nitric oxide, nitric oxide synthase activity, xanthine oxidase activity, total antioxidant capacity, and total oxidant status and to perform histopathological examination. At the 72nd hour after ischemia, the borax group had significantly higher Basso, Beattie, and Bresnahan and inclined-plane scores than those of ischemia/reperfusion group. Histopathological examination of spinal cord tissues in borax group showed that treatment with borax significantly reduced the degree of spinal cord edema, inflammation, and tissue injury disclosed by light microscopy. Xanthine oxidase activity and total oxidant status levels of the ischemia/reperfusion group were significantly higher than those of the sham and borax groups (P borax group were significantly higher than those of the ischemia/reperfusion group (P borax groups in terms of total antioxidant capacity levels (P > .05). The nitric oxide levels and nitric oxide synthase activity of all groups were similar (P > .05). Borax treatment seems to protect the spinal cord against injury in a rat ischemia/reperfusion model and improve neurological outcome. Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  16. Granulocyte Colony-Stimulating Factor Combined with Methylprednisolone Improves Functional Outcomes in Rats with Experimental Acute Spinal Cord Injury

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    William Gemio Jacobsen Teixeira

    2018-02-01

    Full Text Available OBJECTIVES: To evaluate the effects of combined treatment with granulocyte colony-stimulating factor (G-CSF and methylprednisolone in rats subjected to experimental spinal cord injury. METHODS: Forty Wistar rats received a moderate spinal cord injury and were divided into four groups: control (no treatment; G-CSF (G-CSF at the time of injury and daily over the next five days; methylprednisolone (methylprednisolone for 24 h; and G-CSF/Methylprednisolone (methylprednisolone for 24 h and G-CSF at the time of injury and daily over the next five days. Functional evaluation was performed using the Basso, Beattie and Bresnahan score on days 2, 7, 14, 21, 28, 35 and 42 following injury. Motor-evoked potentials were evaluated. Histological examination of the spinal cord lesion was performed immediately after euthanasia on day 42. RESULTS: Eight animals were excluded (2 from each group due to infection, a normal Basso, Beattie and Bresnahan score at their first evaluation, or autophagy, and 32 were evaluated. The combination of methylprednisolone and G-CSF promoted greater functional improvement than methylprednisolone or G-CSF alone (p<0.001. This combination also exhibited a synergistic effect, with improvements in hyperemia and cellular infiltration at the injury site (p<0.001. The groups displayed no neurophysiological differences (latency p=0.85; amplitude p=0.75. CONCLUSION: Methylprednisolone plus G-CSF promotes functional and histological improvements superior to those achieved by either of these drugs alone when treating spinal cord contusion injuries in rats. Combining the two drugs did have a synergistic effect.

  17. Geohydrology of the unsaturated zone at the burial site for low-level radioactive waste near Beatty, Nye County, Nevada

    International Nuclear Information System (INIS)

    Nichols, W.D.

    1987-01-01

    Low-level radioactive solid waste has been buried in trenches at a site near Beatty, NV, since 1962. In 1976, as part of a national program, the US Geological Survey began a study of the geohydrology of the waste burial site to provide a basis for estimating the potential for radionuclide migration in the unsaturated zone beneath the waste burial trenches. The waste burial facility is in the northern Amargosa Desert about 170 kilometers (km) northwest of Las Vegas, NV. The site is underlain by poorly stratified deposits of gravelly or silty sand and sandy gravel, and thick beds of clayey sediments. A numerical analysis demonstrated that a potential exists for deep percolation despite high annual evaporation demands, and provided predictions of the time of year and the antecedent conditions that enhance the probability of deep percolation. Soil moisture profiles obtained monthly over an 18-month period demonstrate that deep percolation does occur. Calculation of downward moisture movement through the waste trench backfill material, on the basis of simplified assumptions, suggests that moisture could have penetrated as much as 6 m below land surface from 1963, when the oldest trenches were closed, to 1980, but that the moisture requirement for such penetration far exceeded the amount of moisture actually available. Steady-state downward movement of moisture at depths greater than 10 m and beneath the waste burial trenches would be on the order of 4 cu m/1,000 yr, assuming a steady flux rate of 0.1 microcentimeter/day. 37 refs., 32 figs., 17 tab

  18. Beatty, Nevada: A section in U.S. Geological Survey research in radioactive waste disposal - Fiscal years 1983, 1984, and 1985 (WRI 87-4009)

    Science.gov (United States)

    Fischer, Jeffrey M.; Nichols, William D.; Dinwiddie, G.A.; Trask, N.J.

    1986-01-01

    A commercial low-level radioactive-waste disposal site has been operating near Beatty, Nevada, about 150 km northwest of Las Vegas, since 1962. The 32-ha site is situated in a desolate region of the Amargosa River Valley, sometimes referred to as the Amargosa Desert. Average annual precipitation is only about 114 mm. The site is underlain by 175 m of unconsolidated, generally coarse-grained, alluvial-fan and flood-plain deposits. The water table is at a depth of 90 m.

  19. Sediment properties and water movement through shallow unsaturated alluvium at an arid site for disposal of low-level radioactive waste near Beatty, Nye County, Nevada

    Science.gov (United States)

    Fischer, Jeffrey M.

    1992-01-01

    A commercial disposal facility for low-level radioactive waste has been in operation near Beatty, Nevada, since 1962. The facility is in the arid Amargosa Desert where wastes are buried in trenches excavated into unsaturated alluvial sediments. Thick unsaturated zones in arid environments offer many potential advantages for disposal of radioactive wastes, but little is known about the natural movement of water near such facilities. Thus, a study was begun in 1982 to better define the direction and rates of water movement through the unsaturated zone in undisturbed sediments near the disposal facility. This report discusses the analyses of data collected between 1983 and 1988.

  20. Population dynamics of toxic phytoplankton and bacterial flora in the waters of the low Adriatic sea; Dinamica di popolazione di fitoplancton tossico e flora batterica nel basso Adriatico

    Energy Technology Data Exchange (ETDEWEB)

    Caroppo, C.; Stabili, L.; Cavallo, R.A.; Pastore, M. [CNR, Ist. Sperimentale Talassografico Attlio Cerruti, Taranto (Italy); Marchiori, E. [Rome Univ., Rome (Italy). Dipt. di Chimica Organica; Bruno, M. [Istituto Superiore di Sanita' , Laboratorio di Igiene Ambientale, Rome (Italy)

    2000-07-01

    The coastal areas of the Southern Adriatic Sea, in particular the Apulian ones, may be considered an example of intact ecosystem and represent an ideal term of comparison to other marine ecosystems having higher levels of pollution (Northern Adriatic Sea). In order to evaluate the sanitary levels of this environment, four transect were investigated during two years monitoring (April 1995-March 1997) along the Otranto Channel coasts, by joint research groups of the Environmental Hygiene Laboratory of the Istituto Superiore di Sanita' and the Istituto Sperimentale Talassografico A. Cerruti of CNR in Taranto. The study underlines the phytoplanktic and bacterial population dynamics, and the detection of the microbiological water quality along the coast tract Brindisi-Lecce-Otranto-S. Maria di Leuca. The results acquired pointed out population dynamics of some potantially toxic species of Dinophysis genus and Pseudo-nitzschia delicatissima. These depended on the winter nutrient loads due to the ASW (Adriatic Superficial Waters) and to the LIW (Levantine Intermediate Waters). The bacterial community was mainly constituted by genera Aeromonas, Photobacterium, Cytophaga and Pseudomonas. Also the presence of Enterobacteriaceae family was relevant. Among the pathogenic vibrios the most frequently isolated species were Vibrio alginolyticus and Vibrio vulnificus. [Italian] Considerando che le zone del basso Adriatico, in particolare quelle pugliesi, costituiscono un biotopo ancora relativamente inalterato, esse sono state oggetto di un'indagine sperimentale condotta in 24 mesi di attivita' (aprile 1995-marzo 1997) lungo le coste del Canale di Otranto, ad opera di un gruppo congiunto del Laboratorio di Igiene Ambientale dell'Istituto Superiore di Sanita' e dei laboratori dell'Istituto Sperimentale Talassografico A. Cerruti del CNR di Taranto, ai fini di valutare lo stato di salute di questo ambiente, che fornisce, con buona probabilita', un

  1. Micrometeorological, evapotranspiration, and soil-moisture data at the Amargosa Desert Research site in Nye County near Beatty, Nevada, 2006-11

    Science.gov (United States)

    Arthur, Jonathan M.; Johnson, Michael J.; Mayers, C. Justin; Andraski, Brian J.

    2012-01-01

    This report describes micrometeorological, evapotranspiration, and soil-moisture data collected since 2006 at the Amargosa Desert Research Site adjacent to a low-level radio-active waste and hazardous chemical waste facility near Beatty, Nevada. Micrometeorological data include precipitation, solar radiation, net radiation, air temperature, relative humidity, saturated and ambient vapor pressure, wind speed and direction, barometric pressure, near-surface soil temperature, soil-heat flux, and soil-water content. Evapotranspiration (ET) data include latent-heat flux, sensible-heat flux, net radiation, soil-heat flux, soil temperature, air temperature, vapor pressure, and other principal energy-budget data. Soil-moisture data include periodic measurements of volumetric water-content at experimental sites that represent vegetated native soil, devegetated native soil, and simulated waste disposal trenches - maximum measurement depths range from 5.25 to 29.25 meters. All data are compiled in electronic spreadsheets that are included with this report.

  2. Magnetic investigation and 2½ D gravity profile modelling across the Beattie magnetic anomaly in the southeastern Karoo Basin, South Africa

    Science.gov (United States)

    Baiyegunhi, Christopher; Gwavava, Oswald

    2017-03-01

    The southeastern Karoo Basin is considered to be one of the most prospective areas for shale gas exploration in South Africa. An interesting magnetic anomaly, the Beattie magnetic anomaly (BMA), and geologic intrusions are seen on the magnetic map. To date, the source of the BMA and interconnectivity of the igneous intrusions are not well understood. In this study, we investigate the interconnectivity of the igneous intrusions and possible location of the source of the BMA using gravity and magnetic methods. The gravity model results showed that igneous intrusions are interconnected at depth, which probably pose threat by increasing the risk of fracking the Karoo for shale gas exploration. The magnetic results revealed that the BMA becomes stronger with depth. The average depths to the top of the shallow and deep magnetic sources were estimated to be approximately 0.6 and 15 km, respectively.

  3. Beatty, Nevada: A section in U.S. Geological Survey research in radioactive waste disposal - Fiscal years 1986-1990 (WRI 91-4084)

    Science.gov (United States)

    Andraski, Brian J.; Fisher, Jeffrey M.; Prudic, David E.; Trask, N.J.; Stevens, P.R.

    1991-01-01

    A low-level radioactive-waste disposal facility in the Amargosa Desert of Nevada, about 17 km southeast of Beatty and 169 km northwest of Las Vegas, has been operating since 1962. This was the first commercially operated radioactive waste disposal facility in the United States. Wastes at the facility are emplaced in 2 to 15-m deep trenches and covered by backfilling with previously excavated materials. Annual precipitation in the area averages about 112 mm. Vegetation is sparse with creosote bush (Larrea tridentata) being the dominant species. Soils in the area are skeletal and are underlain by more than 170 m of unconsolidated alluvial-fan, fluvial, and ephemeral-lake deposits. Depth to water is about 85 m.Initial field investigations (1976-1980) included monitoring of soil-water content and water potential in an unvegetated soil profile, and collection of meteorological data at the disposal facility. Design of additional hydrogeologic investigations and long-term studies of soil-water movement in a vegetated soil profile began in 1982 and field data collection has been ongoing since 1984. Studies to evaluate the modifying effects of trench construction on the natural site environment and to determine changes in trench structural stability began in 1987. Design of studies to measure gas and vapor movement in the trenches at the facility began in 1989.

  4. Application of frequency- and time-domain electromagnetic surveys to characterize hydrostratigraphy and landfill construction at the Amargosa Desert Research Site, Beatty, Nevada

    Science.gov (United States)

    White, Eric A.; Day-Lewis, Frederick D.; Johnson, Carole D.; Lane, John W.

    2016-01-01

    In 2014 and 2015, the U.S. Geological Survey (USGS), conducted frequency-domain electromagnetic (FDEM) surveys at the USGS Amargosa Desert Research Site (ADRS), approximately 17 kilometers (km) south of Beatty, Nevada. The FDEM surveys were conducted within and adjacent to a closed low-level radioactive waste disposal site located at the ADRS. FDEM surveys were conducted on a grid of north-south and east-west profiles to assess the locations and boundaries of historically recorded waste-disposal trenches. In 2015, the USGS conducted time-domain (TDEM) soundings along a profile adjacent to the disposal site (landfill) in cooperation with the U.S. Environmental Protection Agency (USEPA), to assess the thickness and characteristics of the underlying deep unsaturated zone, and the hydrostratigraphy of the underlying saturated zone.FDEM survey results indicate the general location and extent of the waste-disposal trenches and reveal potential differences in material properties and the type and concentration of waste in several areas of the landfill. The TDEM surveys provide information on the underlying hydrostratigraphy and characteristics of the unsaturated zone that inform the site conceptual model and support an improved understanding of the hydrostratigraphic framework. Additional work is needed to interpret the TDEM results in the context of the local and regional structural geology.

  5. Realizzazione di un sistema di monitoraggio del rumore a basso costo attraverso la nuova app Android “Openoise” - Implementation of a low-cost noise measurementsystem through the new Android app “Openoise”

    Directory of Open Access Journals (Sweden)

    Stefano Masera

    2016-07-01

    Full Text Available Nel presente lavoro si propone di utilizzare i più comuni dispositivi per le telecomunicazioni, quali smartphone e tablet, come alternativa a basso costo attendibile per l’esecuzione di misure di rumore. A tal fine è stata sviluppata una nuova applicazione con codice opensource, denominata OpeNoise, scaricabile gratuitamente dal Market Android Google Play. Per verificarne l’attendibilità sono stati effettuati opportuni test in laboratorio e sul campo. I risultati sono estremamente incoraggianti e lasciano intravedere un possibile futuro per questo settore di sviluppo. ------ In this paper it has been investigated the possibility of using the most common ICT devices, like smartphones and tablet, as a low-cost alternative for noise measuring. In particular, it has been developed a new free and open-source application, called Ope-Noise, downloadable in the Android Market Google Play. To verify the reliability of OpeNoise, a series of laboratory and in-field tests has been carried out. The results are really encouraging and open a path toward new developments in this field.

  6. Soil, plant, and structural considerations for surface barriers in arid environments: Application of results from studies in the Mojave Desert near Beatty, Nevada

    Science.gov (United States)

    Andraski, Brian J.; Prudic, David E.; ,

    1997-01-01

    The suitability of a waste-burial site depends on hydrologic processes that can affect the near-surface water balance. In addition, the loss of burial trench integrity by erosion and subsidence of trench covers may increase the likelihood of infiltration and percolation, thereby reducing the effectiveness of the site in isolating waste. Although the main components of the water balance may be defined, direct measurements can be difficult, and actual data for specific locations are seldom available. A prevalent assumption is that little or no precipitation will percolate to buried wastes at an arid site. Thick unsaturated zones, which are common to arid regions, are thought to slow water movement and minimize the risk of waste migration to the underlying water table. Thus, reliance is commonly placed on the natural system to isolate contaminants at waste-burial sites in the arid West.Few data are available to test assumptions about the natural soil-water flow systems at arid sites, and even less is known about how the natural processes are altered by construction of a waste-burial facility. The lack of data is the result of technical complexity of hydraulic characterization of the dry, stony soils, and insufficient field studies that account for the extreme temporal and spatial variations in precipitation, soils, and plants in arid regions. In 1976, the U.S. Geological Survey (USGS) began a long-term study at a waste site in the Mojave Desert. This paper summarizes the findings of ongoing investigations done under natural-site and waste-burial conditions, and discusses how this information may be applied to the design of surface barriers for waste sites in arid environments.The waste-burial site is in one of the most arid parts of the United States and is about 40 km northeast of Death Valley, near Beatty, Nev. (Figure 1). Precipitation averaged 108 mm/yr during 1981-1992. The water table is 85-115 m below land surface (Fischer, 1992). Sediments are largely alluvial

  7. Selected micrometeorological, soil-moisture, and evapotranspiration data at Amargosa Desert Research Site in Nye County near Beatty, Nevada, 2001-05

    Science.gov (United States)

    Johnson, Michael J.; Mayers, C. Justin; Garcia, C. Amanda; Andraski, Brian J.

    2007-01-01

    Selected micrometeorological and soil-moisture data were collected at the Amargosa Desert Research Site adjacent to a low-level radio-active waste and hazardous chemical waste facility near Beatty, Nevada, 2001-05. Evapotranspiration data were collected from February 2002 through the end of December 2005. Data were col-lected in support of ongoing research to improve the understanding of hydrologic and contaminant-transport processes in arid environments. Micrometeorological data include solar radiation, net radiation, air temperature, relative humidity, saturated and ambient vapor pressure, wind speed and direction, barometric pressure, precipitation, near-surface soil temperature, soil-heat flux and soil-water content. All micrometeorological data were collected using a 10-second sampling interval by data loggers that output daily and hourly mean values. Daily maximum and minimum values are based on hourly mean values. Precipitation data output includes daily and hourly totals. Selected soil-moisture profiles at depth include periodic measurements of soil volumetric water-content measurements at nine neutron-probe access tubes to depths ranging from 5.25 to 29.25 meters. Evapotranspiration data include measurement of daily evapotranspiration and 15-minute fluxes of the four principal energy budget components of latent-heat flux, sensible-heat flux, soil-heat flux, and net radiation. Other data collected and used in equations to determine evapotranspiration include temperature and water content of soil, temperature and vapor pressure of air, and covariance values. Evapotranspiration and flux estimates during 15-minute intervals were calculated at a 0.1-second execution interval using the eddy covariance method. Data files included in this report contain the complete micrometeorological, soil-moisture, and evapotranspiration field data sets. These data files are presented in tabular Excel spreadsheet format. This report highlights selected data contained in the

  8. Selected micrometeorological and soil-moisture data at Amargosa Desert Research Site, an arid site near Beatty, Nye County, Nevada, 1998-2000

    Science.gov (United States)

    Johnson, Michael J.; Mayers, Charles J.; Andraski, Brian J.

    2002-01-01

    Selected micrometeorological and soil-moisture data were collected at the Amargosa Desert Research Site adjacent to a low-level radioactive waste and hazardous chemical waste facility near Beatty, Nev., 1998-2000. Data were collected in support of ongoing research studies to improve the understanding of hydrologic and contaminant-transport processes in arid environments. Micrometeorological data include precipitation, air temperature, solar radiation, net radiation, relative humidity, ambient vapor pressure, wind speed and direction, barometric pressure, soil temperature, and soil-heat flux. All micrometeorological data were collected using a 10-second sampling interval by data loggers that output daily mean, maximum, and minimum values, and hourly mean values. For precipitation, data output consisted of daily, hourly, and 5-minute totals. Soil-moisture data included periodic measurements of soil-water content at nine neutron-probe access tubes with measurable depths ranging from 5.25 to 29.75 meters. The computer data files included in this report contain the complete micrometeorological and soil-moisture data sets. The computer data consists of seven files with about 14 megabytes of information. The seven files are in tabular format: (1) one file lists daily mean, maximum, and minimum micrometeorological data and daily total precipitation; (2) three files list hourly mean micrometeorological data and hourly precipitation for each year (1998-2000); (3) one file lists 5-minute precipitation data; (4) one file lists mean soil-water content by date and depth at four experimental sites; and (5) one file lists soil-water content by date and depth for each neutron-probe access tube. This report highlights selected data contained in the computer data files using figures, tables, and brief discussions. Instrumentation used for data collection also is described. Water-content profiles are shown to demonstrate variability of water content with depth. Time-series data are

  9. The Anti-Inflammatory Compound Curcumin Enhances Locomotor and Sensory Recovery after Spinal Cord Injury in Rats by Immunomodulation

    Science.gov (United States)

    Machova Urdzikova, Lucia; Karova, Kristyna; Ruzicka, Jiri; Kloudova, Anna; Shannon, Craig; Dubisova, Jana; Murali, Raj; Kubinova, Sarka; Sykova, Eva; Jhanwar-Uniyal, Meena; Jendelova, Pavla

    2015-01-01

    Well known for its anti-oxidative and anti-inflammation properties, curcumin is a polyphenol found in the rhizome of Curcuma longa. In this study, we evaluated the effects of curcumin on behavioral recovery, glial scar formation, tissue preservation, axonal sprouting, and inflammation after spinal cord injury (SCI) in male Wistar rats. The rats were randomized into two groups following a balloon compression injury at the level of T9–T10 of the spinal cord, namely vehicle- or curcumin-treated. Curcumin was applied locally on the surface of the injured spinal cord immediately following injury and then given intraperitoneally daily; the control rats were treated with vehicle in the same manner. Curcumin treatment improved behavioral recovery within the first week following SCI as evidenced by improved Basso, Beattie, and Bresnahan (BBB) test and plantar scores, representing locomotor and sensory performance, respectively. Furthermore, curcumin treatment decreased glial scar formation by decreasing the levels of MIP1α, IL-2, and RANTES production and by decreasing NF-κB activity. These results, therefore, demonstrate that curcumin has a profound anti-inflammatory therapeutic potential in the treatment of spinal cord injury, especially when given immediately after the injury. PMID:26729105

  10. MicroRNA-146a Contributes to SCI Recovery via Regulating TRAF6 and IRAK1 Expression.

    Science.gov (United States)

    Wei, Jinsong; Wang, Jiafeng; Zhou, Yulan; Yan, Shouquan; Li, Keshen; Lin, Hongsheng

    2016-01-01

    MicroRNA-146a participates in spinal cord injury (SCI) recovery. Until recently, how miRNA-146a participates in SCI remained unclear. In this study, we tried to explore the roles of miRNA-146a in the recovery of SCI using a rat model. The expression of the probable target genes of miRNA-146a (including IRAK1 and TARF6) as well as proinflammation cytokines were measured until 7 days after surgery in the three groups (sham group, SCI group, and miRNA-146a antagomir injection group). Also, the animals' motivations were estimated using Basso Beattie Bresnahan (BBB) during the whole experiment. A luciferase assay was performed to demonstrate that miRNA-146a could directly target the mRNAs of IRAK1 and TRAF6 . Our experiments indicate that miRNA-146a inhibits proinflammatory cytokine secretion by suppressing IRAK1 and TRAF6 expression in the SCI model. In contrast, miRNA-146a may be upregulated by inflammatory mediators via the IRAK1 / TRAF6 pathway in the spinal cord. As a negative feedback element, miRNA-146a could make sure that the expression of IRAK1 - and TRAF6 -mediated genes was under tight control. Thus, miRNA-146a may serve as a novel therapeutic target for SCI interventions.

  11. Engraftment, neuroglial transdifferentiation and behavioral recovery after complete spinal cord transection in rats.

    Science.gov (United States)

    Sabino, Luzzi; Maria, Crovace Alberto; Luca, Lacitignola; Valerio, Valentini; Edda, Francioso; Giacomo, Rossi; Gloria, Invernici; Juan, Galzio Renato; Antonio, Crovace

    2018-01-01

    Proof of the efficacy and safety of a xenogeneic mesenchymal stem cell (MSCs) transplant for spinal cord injury (SCI) may theoretically widen the spectrum of possible grafts for neuroregeneration. Twenty rats were submitted to complete spinal cord transection. Ovine bone marrow MSCs, retrovirally transfected with red fluorescent protein and not previously induced for neuroglial differentiation, were applied in 10 study rats (MSCG). Fibrin glue was injected in 10 control rats (FGG). All rats were evaluated on a weekly basis and scored using the Basso-Beattie-Bresnahan (BBB) locomotor scale for 10 weeks, when the collected data were statistically analyzed. The spinal cords were then harvested and analyzed with light microscopy, immunohistochemistry, and immunofluorescence. Ovine MSCs culture showed positivity for Nestin. MSCG had a significant and durable recovery of motor functions ( P <.001). Red fluorescence was found at the injury sites in MSCG. Positivity for Nestin, tubulin βIII, NG2 glia, neuron-specific enolase, vimentin, and 200 kD neurofilament were also found at the same sites. Xenogeneic ovine bone marrow MSCs proved capable of engrafting into the injured rat spinal cord. Transdifferentiation into a neuroglial phenotype was able to support partial functional recovery.

  12. Abdominal Manual Therapy Repairs Interstitial Cells of Cajal and Increases Colonic c-Kit Expression When Treating Bowel Dysfunction after Spinal Cord Injury

    Directory of Open Access Journals (Sweden)

    Yi Zhu

    2017-01-01

    Full Text Available Background. This study aimed to evaluate the therapeutic effects of abdominal manual therapy (AMT on bowel dysfunction after spinal cord injury (SCI, investigating interstitial cells of Cajal (ICCs and related c-kit expression. Methods. Model rats were divided as SCI and SCI with drug treatment (intragastric mosapride, low-intensity (SCI + LMT; 50 g, 50 times/min, and high-intensity AMT (SCI + HMT; 100 g, 150 times/min. After 14 days of treatment, weight, improved Basso-Beattie-Bresnahan (BBB locomotor score, and intestinal movement were evaluated. Morphological structure of spinal cord and colon tissues were examined. Immunostaining, RT-PCR, and western blot were used to assess c-kit expression. Results. In SCI rats, AMT could not restore BBB, but it significantly increased weight, shortened time to defecation, increased feces amounts, and improved fecal pellet traits and colon histology. AMT improved the number, distribution, and ultrastructure of colonic ICCs, increasing colonic c-kit mRNA and protein levels. Compared with the SCI + Drug and SCI + LMT groups, the SCI + HMT group showed better therapeutic effect in improving intestinal transmission function and promoting c-kit expression. Conclusions. AMT is an effective therapy for recovery of intestinal transmission function. It could repair ICCs and increase c-kit expression in colon tissues after SCI, in a frequency-dependent and pressure-dependent manner.

  13. Early application of tail nerve electrical stimulation-induced walking training promotes locomotor recovery in rats with spinal cord injury.

    Science.gov (United States)

    Zhang, S-X; Huang, F; Gates, M; Shen, X; Holmberg, E G

    2016-11-01

    This is a randomized controlled prospective trial with two parallel groups. The objective of this study was to determine whether early application of tail nerve electrical stimulation (TANES)-induced walking training can improve the locomotor function. This study was conducted in SCS Research Center in Colorado, USA. A contusion injury to spinal cord T10 was produced using the New York University impactor device with a 25 -mm height setting in female, adult Long-Evans rats. Injured rats were randomly divided into two groups (n=12 per group). One group was subjected to TANES-induced walking training 2 weeks post injury, and the other group, as control, received no TANES-induced walking training. Restorations of behavior and conduction were assessed using the Basso, Beattie and Bresnahan open-field rating scale, horizontal ladder rung walking test and electrophysiological test (Hoffmann reflex). Early application of TANES-induced walking training significantly improved the recovery of locomotor function and benefited the restoration of Hoffmann reflex. TANES-induced walking training is a useful method to promote locomotor recovery in rats with spinal cord injury.

  14. Improved Neural Regeneration with Olfactory Ensheathing Cell Inoculated PLGA Scaffolds in Spinal Cord Injury Adult Rats

    Directory of Open Access Journals (Sweden)

    Changxing Wang

    2017-03-01

    Full Text Available Background/Aims: Every year, around the world, between 250000 and 500000 people suffer from spinal cord injury (SCI. This study investigated the potential for poly (lactic-co-glycolic acid (PLGA complex inoculated with olfactory ensheathing cells (OECs to treat spinal cord injury in a rat model. Methods: OECs were identified by immunofluorescence based on the nerve growth factor receptor (NGFR p75. The Basso, Beattie, and Bresnahan (BBB score, together with an inclined plane (IP test were used to detect functional recovery. Nissl staining along with the luxol fast blue (LFB staining were independently employed to illustrate morphological alterations. More so, immunofluorescence labeling of the glial fibrillary acidic protein (GFAP and the microtubule-associated protein-2 (MAP-2, representing astrocytes and neurons respectively, were investigated at time points of weeks 2 and 8 post-operation. Results: The findings showed enhanced locomotor recovery, axon myelination and better protected neurons post SCI when compared with either PLGA or untreated groups (P < 0.05. Conclusion: PLGA complexes inoculated with OECs improve locomotor functional recovery in transected spinal cord injured rat models, which is most likely due to the fact it is conducive to a relatively benevolent microenvironment, has nerve protective effects, as well as the ability to enhance remyelination, via a promotion of cell differentiation and inhibition of astrocyte formation.

  15. Protective effect of nicotinamide adenine dinucleotide (NAD+) against spinal cord ischemia-reperfusion injury via reducing oxidative stress-induced neuronal apoptosis.

    Science.gov (United States)

    Xie, Lei; Wang, Zhenfei; Li, Changwei; Yang, Kai; Liang, Yu

    2017-02-01

    As previous studies demonstrate that oxidative stress and apoptosis play crucial roles in ischemic pathogenesis and nicotinamide adenine dinucleotide (NAD + ) treatment attenuates oxidative stress-induced cell death among primary neurons and astrocytes as well as significantly reduce cerebral ischemic injury in rats. We used a spinal cord ischemia injury (SCII) model in rats to verify our hypothesis that NAD + could ameliorate oxidative stress-induced neuronal apoptosis. Adult male rats were subjected to transient spinal cord ischemia for 60min, and different doses of NAD + were administered intraperitoneally immediately after the start of reperfusion. Neurological function was determined by Basso, Beattie, Bresnahan (BBB) scores. The oxidative stress level was assessed by superoxide dismutase (SOD) activity and malondialdehyde (MDA) content. The degree of apoptosis was analyzed by deoxyuridinetriphosphate nick-end labeling (TUNEL) staining and protein levels of cleaved caspase-3 and AIF (apoptosis inducing factor). The results showed that NAD + at 50 or 100mg/kg significantly decreased the oxidative stress level and neuronal apoptosis in the spinal cord of ischemia-reperfusion rats compared with saline, as accompanied with the decreased oxidative stress, NAD + administration significantly restrained the neuronal apoptosis after ischemia injury while improved the neurological and motor function. These findings suggested that NAD + might protect against spinal cord ischemia-reperfusion via reducing oxidative stress-induced neuronal apoptosis. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Repetitive Treatment with Diluted Bee Venom Attenuates the Induction of Below-Level Neuropathic Pain Behaviors in a Rat Spinal Cord Injury Model.

    Science.gov (United States)

    Kang, Suk-Yun; Roh, Dae-Hyun; Choi, Jung-Wan; Ryu, Yeonhee; Lee, Jang-Hern

    2015-07-10

    The administration of diluted bee venom (DBV) into an acupuncture point has been utilized traditionally in Eastern medicine to treat chronic pain. We demonstrated previously that DBV has a potent anti-nociceptive efficacy in several rodent pain models. The present study was designed to examine the potential anti-nociceptive effect of repetitive DBV treatment in the development of below-level neuropathic pain in spinal cord injury (SCI) rats. DBV was applied into the Joksamli acupoint during the induction and maintenance phase following thoracic 13 (T13) spinal hemisection. We examined the effect of repetitive DBV stimulation on SCI-induced bilateral pain behaviors, glia expression and motor function recovery. Repetitive DBV stimulation during the induction period, but not the maintenance, suppressed pain behavior in the ipsilateral hind paw. Moreover, SCI-induced increase in spinal glia expression was also suppressed by repetitive DBV treatment in the ipsilateral dorsal spinal cord. Finally, DBV injection facilitated motor function recovery as indicated by the Basso-Beattie-Bresnahan rating score. These results indicate that the repetitive application of DBV during the induction phase not only decreased neuropathic pain behavior and glia expression, but also enhanced locomotor functional recovery after SCI. This study suggests that DBV acupuncture can be a potential clinical therapy for SCI management.

  17. Electroacupuncture at Dazhui (GV14 and Mingmen (GV4 protects against spinal cord injury: the role of the Wnt/β-catenin signaling pathway

    Directory of Open Access Journals (Sweden)

    Xin Wang

    2016-01-01

    Full Text Available Electroacupuncture at Dazhui (GV14 and Mingmen (GV4 on the Governor Vessel has been shown to exhibit curative effects on spinal cord injury; however, the underlying mechanism remains poorly understood. In this study, we established rat models of spinal cord injury using a modified Allen's weight-drop method. Ninety-nine male Sprague-Dawley rats were randomly divided into three equal groups: sham (only laminectomy, SCI (induction of spinal cord injury at T10, and EA (induction of spinal cord injury at T10 and electroacupuncture intervention at GV14 and GV4 for 20 minutes once a day. Rats in the SCI and EA groups were further randomly divided into the following subgroups: 1-day (n = 11, 7-day (n = 11, and 14-day (n = 11. At 1, 7, and 14 days after electroacupuncture treatment, the Basso, Beattie and Bresnahan locomotor rating scale showed obvious improvement in rat hind limb locomotor function, hematoxylin-eosin staining showed that the histological change of injured spinal cord tissue was obviously alleviated, and immunohistochemistry and western blot analysis showed that Wnt1, Wnt3a, β-catenin immunoreactivity and protein expression in the injured spinal cord tissue were greatly increased compared with the sham and SCI groups. These findings suggest that electroacupuncture at GV14 and GV4 upregulates Wnt1, Wnt3a, and β-catenin expression in the Wnt/β-catenin signaling pathway, exhibiting neuroprotective effects against spinal cord injury.

  18. The neuroprotective effect of treatment with curcumin in acute spinal cord injury: laboratory investigation.

    Science.gov (United States)

    Kim, Kyoung-Tae; Kim, Myoung-Jin; Cho, Dae-Chul; Park, Seong-Hyun; Hwang, Jeong-Hyun; Sung, Joo-Kyung; Cho, Hee-Jung; Jeon, Younghoon

    2014-01-01

    The purpose of this study was investigating the effects of curcumin on the histological changes and functional recovery following spinal cord injury (SCI) in a rat model. Following either sham operation or SCI, 36 male Sprague-Dawley rats were distributed into three groups: sham group, curcumin-treated group, and vehicle-injected group. Locomotor function was assessed according to the Basso, Beattie, and Bresnahan (BBB) scale in rats who had received daily intraperitoneal injections of 200 mg/kg curcumin or an equivalent volume of vehicle for 7 days following SCI. The injured spinal cord was then examined histologically, including quantification of cavitation. BBB scores were significantly higher in rats receiving curcumin than receiving vehicle (P curcumin group as compared to the control group (P = 0.039). Superoxide dismutase (SOD) activity was significantly elevated in the curcumin group as compared to the vehicle group but was not significantly different from the sham group (P 0.05, respectively) at one and two weeks after SCI. Malondialdehyde (MDA) levels were significantly elevated in the vehicle group as compared to the sham group (P curcumin group at 2 weeks after SCI when compared to the vehicle group (P = 0.004). The numbers of macrophage were significantly decreased in the curcumin group (P = 0.001). This study demonstrated that curcumin enhances early functional recovery after SCI by diminishing cavitation volume, anti-inflammatory reactions, and antioxidant activity.

  19. Visual bone marrow mesenchymal stem cell transplantation in the repair of spinal cord injury

    Directory of Open Access Journals (Sweden)

    Rui-ping Zhang

    2015-01-01

    Full Text Available An important factor in improving functional recovery from spinal cord injury using stem cells is maximizing the number of transplanted cells at the lesion site. Here, we established a contusion model of spinal cord injury by dropping a weight onto the spinal cord at T 7-8 . Superparamagnetic iron oxide-labeled bone marrow mesenchymal stem cells were transplanted into the injured spinal cord via the subarachnoid space. An outer magnetic field was used to successfully guide the labeled cells to the lesion site. Prussian blue staining showed that more bone marrow mesenchymal stem cells reached the lesion site in these rats than in those without magnetic guidance or superparamagnetic iron oxide labeling, and immunofluorescence revealed a greater number of complete axons at the lesion site. Moreover, the Basso, Beattie and Bresnahan (BBB locomotor rating scale scores were the highest in rats with superparamagnetic labeling and magnetic guidance. Our data confirm that superparamagnetic iron oxide nanoparticles effectively label bone marrow mesenchymal stem cells and impart sufficient magnetism to respond to the external magnetic field guides. More importantly, superparamagnetic iron oxide-labeled bone marrow mesenchymal stem cells can be dynamically and non-invasively tracked in vivo using magnetic resonance imaging. Superparamagnetic iron oxide labeling of bone marrow mesenchymal stem cells coupled with magnetic guidance offers a promising avenue for the clinical treatment of spinal cord injury.

  20. Chondroitinase ABC plus bone marrow mesenchymal stem cells for repair of spinal cord injury☆

    Science.gov (United States)

    Zhang, Chun; He, Xijing; Li, Haopeng; Wang, Guoyu

    2013-01-01

    As chondroitinase ABC can improve the hostile microenvironment and cell transplantation is proven to be effective after spinal cord injury, we hypothesized that their combination would be a more effective treatment option. At 5 days after T8 spinal cord crush injury, rats were injected with bone marrow mesenchymal stem cell suspension or chondroitinase ABC 1 mm from the edge of spinal cord damage zone. Chondroitinase ABC was first injected, and bone marrow mesenchymal stem cell suspension was injected on the next day in the combination group. At 14 days, the mean Basso, Beattie and Bresnahan score of the rats in the combination group was higher than other groups. Hematoxylin-eosin staining showed that the necrotic area was significantly reduced in the combination group compared with other groups. Glial fibrillary acidic protein-chondroitin sulfate proteoglycan double staining showed that the damage zone of astrocytic scars was significantly reduced without the cavity in the combination group. Glial fibrillary acidic protein/growth associated protein-43 double immunostaining revealed that positive fibers traversed the damage zone in the combination group. These results suggest that the combination of chondroitinase ABC and bone marrow mesenchymal stem cell transplantation contributes to the repair of spinal cord injury. PMID:25206389

  1. Regulatory effect of neuroglobin in the recovery of spinal cord injury.

    Science.gov (United States)

    Dai, Ji-Lin; Lin, Yun; Yuan, Yong-Jian; Xing, Shi-Tong; Xu, Yi; Zhang, Qiang-Hua; Min, Ji-Kang

    2017-11-16

    The present study was aimed to investigate the therapeutic potential of neuroglobin in the recovery of spinal cord injury. The male albino Wistar strain rats were used as an experimental model, and adeno associated virus (AAV) was administered in the T12 section of spinal cord ten days prior to the injury. Basso Beattie Bresnahan (BBB) locomotor rating scale was used to determine the recovery of the hind limb during four weeks post-operation. Malondialdehyde (MDA), catalase and superoxide dismutase (SOD) were determined in the spinal cord tissues. Terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) assay was carried out to determine the presence of apoptotic cells. Immunofluorescence analysis was carried out to determine the neuroglobin expression. Western blot analysis was carried out to determine the protein expressions of caspase-3, cytochrome c, bax and bcl-2 in the spinal cord tissues. Experimental results showed that rats were recovered from the spinal cord injury due to increased neuroglobin expression. Lipid peroxidation was reduced, whereas catalase and SOD activity were increased in the spinal cord tissues. Apoptosis and lesions were significantly reduced in the spinal cord tissues. Caspase-3, cytochrome c and bax levels were significantly reduced, whereas bcl-2 expression was reduced in the spinal cord tissues. Taking all these data together, it is suggested that the increased neuroglobin expression could improve the locomotor function.

  2. Panax ginseng Improves Functional Recovery after Contusive Spinal Cord Injury by Regulating the Inflammatory Response in Rats: An In Vivo Study

    Directory of Open Access Journals (Sweden)

    Young Ock Kim

    2015-01-01

    Full Text Available Spinal cord injury (SCI results in permanent loss of motor function below the injured site. Neuroinflammatory reaction following SCI can aggravate neural injury and functional impairment. Ginseng is well known to possess anti-inflammatory effects. The present study investigated the neuroprotective effects of Panax ginseng C.A. Mayer (P. ginseng after SCI. A spinal contusion was made at the T11-12 spinal cord in adult male Sprague-Dawley rats (n=47 using the NYU impactor. Motor function was assessed using the Basso-Beattie-Bresnahan (BBB score in P. ginseng (0.1, 0.5, 1, 3, and 5 mg/kg or vehicle (saline treated after SCI. We also assessed the protein expression of cyclooxygenase-2 (COX-2 and inducible nitric oxide synthase (iNOS at the lesion site by western blot and then measured the cavity area using luxol fast blue/cresyl violet staining. P. ginseng treated group in SCI showed a significant improvement in locomotor function after the injury. The protein expression of COX-2 and iNOS at the lesion site and the cavity area were decreased following SCI by P. ginseng treatment. These results suggest that P. ginseng may improve the recovery of motor function after SCI which provides neuroprotection by alleviating posttraumatic inflammatory responses.

  3. Technical analysis of volume-rendering algorithms: application in low-contrast structures using liver vascularisation as a model; Analisi tecnica degli algoritmi di volume rendering: applicazione alle strutture a basso contrsto usando come modello la vascolarizzazione epatica

    Energy Technology Data Exchange (ETDEWEB)

    Cademartiri, Filippo [Erasmus Medical Center, Rotterdam (Netherlands); Luccichenti, Giacomo [Fondazione Biomedica Europea ONLUS, Roma (Italy); Runza, Giuseppe; Bartolotta, Tommaso Vincenzo; Midiri, Massimo [Palermo Univ., Palermo (Italy). Sezione di scienze radiologiche; Gualerzi, Massimo; Brambilla, Lorenzo; Coruzzi, Paolo [Parma Univ., Parma (Italy). UO di prevenzione e riabilitazione vascolare, Fondazione Don C. Gnocchi ONLUS; Soliani, Paolo; Sianesi, Mario [Parma Univ., Parma (Italy). Dipartimento di chirurgia

    2005-04-01

    visualizzazione delle strutture vascolari portali (strutture a basso contrasto). Materiale e metodi: Sono stati valutati tramite TC spirale con tecnica bifasica 22 pazienti. I parametri utilizzati per la scansione sono stati: collimazione 3 mm, pitch 2, avanzamento 1 mm. Le scansioni eseguite sono state tre: la prima senza mezzo di contrasto (mdc), le ultime due con iniezioni di mdc (convenzionalmente identificate come 'arteriosa' e 'portale'). Le immagini sono poi state trasferite su una consolle di post-elaborazione dotata di sistema oparativo Windows NT con software per ricostruzioni tridimensionali (3D) in grado di produrre immagini in volume rendering della vascolarizzazione epatica. Sono state valutate: la correlazione tra i valori assoluti dell'aorta, attenuazione del fegato e della vena oprta, i parametri delle CO e la qualit� delle immagini. Risultati: Le immagini 3D ottenute utilizzando le CO preimpostate di ricostruzione possiedono una qualit� molto pi� bassa rispetto a quelle ottenute utilizzando la CO scelta dall'operatore. L'elevato contrasto tra il fegato e la vena porta, per esempio durante la fase portale, utilizza delle finestre pi� larghe, in modo da aumentare la qualit� dell'immagine. Al contrario, nelle scansioni effettuate durante la fase parenchimografica, la CO deve avere un elevato gradiente in modo tale da permettere una migliore distinzione delle strutture vascolari dal parenchima epatico che le circonda. Conclusioni: Le caratteristiche dell'immagine, considerate di interesse per l'operatore, non possono essere semplificate dalla media delle CO preimpostate. Data la loro estrema variabilit� individuale, gli algoritmi 3D automatici non possono essere universalmente applicati: dovrebbero essere adattati sia alle caratteristiche dell'immagine che al paziente.

  4. Análise comparativa da avaliação funcional realizada na lesão medular em animais Comparative analysis of functional evaluation performed in medullary injury in animals

    Directory of Open Access Journals (Sweden)

    Alessandra Iague Molina

    2004-03-01

    Full Text Available A avaliação comportamental após, a contusão da medula espinhal, enfocou por um tempo a locomoção em campo aberto usando uma escala de classificação desenvolvida por Tarlov et al.(18. Tarlov(17 realizou estudos experimentais em cães, produzindo compressão medular com atribuição de zero a cinco para graduação dos movimentos do animal. Contudo, esta escala tem sido modificada por pesquisadores e suas alterações feitas por vários grupos tornaram as comparações das medidas do resultado locomotor difíceis. Um aspecto crítico da pesquisa utilizando lesão medular em animais é a padronização da avaliação da recuperação locomotora. A escala desenvolvida por Tator(19 é simples e de fácil utilização, porém pode não analisar todos os aspectos necessários . Basso, Beattie e Bresnahan(2,3 apresentaram uma escala de classificação com índice de recuperação locomotora em ratos que sofreram lesão medular produzida em laboratório. Os dados indicam que a escala BBB é uma medida válida para a recuperação locomotora capaz de distinguir os resultados comportamentais em função de ferimentos diferentes e para prever alterações anatômicas no centro da lesão. O propósito deste estudo foi analisar e comparar escalas de classificação locomotora sem ambigüidade, eficientes e expandida para se padronizar as medidas resultantes nos laboratórios.The behavior evaluation after a spinal medulla injury focused the locomotion in field during a certain time, using a classification scale developed by Tarlov et al.(18. Tarlov(17 performed experimental studies in dogs, producing medullary compression and assigning a graduation from zero to five to the animal movements. However, this scale has been changed by researchers and its changes, made by several groups, became difficult the comparisons of the measures of the locomotor result. One critical aspect of the research with medullary injury in animals is the standardization of the

  5. Post-spinal cord injury astrocyte-mediated functional recovery in rats after intraspinal injection of the recombinant adenoviral vectors Ad5-VEGF and Ad5-ANG.

    Science.gov (United States)

    Povysheva, Tatyana; Shmarov, Maksim; Logunov, Denis; Naroditsky, Boris; Shulman, Ilya; Ogurcov, Sergey; Kolesnikov, Pavel; Islamov, Rustem; Chelyshev, Yuri

    2017-07-01

    OBJECTIVE The most actively explored therapeutic strategy for overcoming spinal cord injury (SCI) is the delivery of genes encoding molecules that stimulate regeneration. In a mouse model of amyotrophic lateral sclerosis and in preliminary clinical trials in patients with amyotrophic lateral sclerosis, the combined administration of recombinant adenoviral vectors (Ad5-VEGF+Ad5-ANG) encoding the neurotrophic/angiogenic factors vascular endothelial growth factor ( VEGF) and angiogenin ( ANG) was found to slow the development of neurological deficits. These results suggest that there may be positive effects of this combination of genes in posttraumatic spinal cord regeneration. The objective of the present study was to determine the effects of Ad5-VEGF+Ad5-ANG combination therapy on motor function recovery and reactivity of astrocytes in a rat model of SCI. METHODS Spinal cord injury was induced in adult Wistar rats by the weight-drop method. Rats (n = 51) were divided into 2 groups: the experimental group (Ad5-VEGF+Ad5-ANG) and the control group (Ad5-GFP [green fluorescent protein]). Recovery of motor function was assessed using the Basso, Beattie, and Bresnahan scale. The duration and intensity of infectivity and gene expression from the injected vectors were assessed by immunofluorescent detection of GFP. Reactivity of glial cells was assessed by changes in the number of immunopositive cells expressing glial fibrillary acidic protein (GFAP), S100β, aquaporin 4 (AQP4), oligodendrocyte transcription factor 2, and chondroitin sulfate proteoglycan 4. The level of S100β mRNA expression in the spinal cord was estimated by real-time polymerase chain reaction. RESULTS Partial recovery of motor function was observed 30 days after surgery in both groups. However, Basso, Beattie, and Bresnahan scores were 35.9% higher in the Ad5-VEGF+Ad5-ANG group compared with the control group. Specific GFP signal was observed at distances of up to 5 mm in the rostral and caudal

  6. Macrophage depletion and Schwann cell transplantation reduce cyst size after rat contusive spinal cord injury.

    Science.gov (United States)

    Lee, Yee-Shuan; Funk, Lucy H; Lee, Jae K; Bunge, Mary Bartlett

    2018-04-01

    Schwann cell transplantation is a promising therapy for the treatment of spinal cord injury (SCI) and is currently in clinical trials. In our continuing efforts to improve Schwann cell transplantation strategies, we sought to determine the combined effects of Schwann cell transplantation with macrophage depletion. Since macrophages are major inflammatory contributors to the acute spinal cord injury, and are the major phagocytic cells, we hypothesized that transplanting Schwann cells after macrophage depletion will improve cell survival and integration with host tissue after SCI. To test this hypothesis, rat models of contusive SCI at thoracic level 8 were randomly subjected to macrophage depletion or not. In rat subjected to macrophage depletion, liposomes filled with clodronate were intraperitoneally injected at 1, 3, 6, 11, and 18 days post injury. Rats not subjected to macrophage depletion were intraperitoneally injected with liposomes filled with phosphate buffered saline. Schwann cells were transplanted 1 week post injury in all rats. Biotinylated dextran amine (BDA) was injected at thoracic level 5 to evalute axon regeneration. The Basso, Beattie, and Bresnahan locomotor test, Gridwalk test, and sensory test using von Frey filaments were performed to assess functional recovery. Immunohistochemistry was used to detect glial fibrillary acidic protein, neurofilament, and green fluorescent protein (GFP), and also to visulize BDA-labelled axons. The GFP labeled Schwann cell and cyst and lesion volumes were quantified using stained slides. The numbers of BDA-positive axons were also quantified. At 8 weeks after Schwann cell transplantation, there was a significant reduction in cyst and lesion volumes in the combined treatment group compared to Schwann cell transplantation alone. These changes were not associated, however, with improved Schwann cell survival, axon growth, or locomotor recovery. Although combining Schwann cell transplantation with macrophage

  7. Adult opossums (Didelphis virginiana) demonstrate near normal locomotion after spinal cord transection as neonates.

    Science.gov (United States)

    Wang, X M; Basso, D M; Terman, J R; Bresnahan, J C; Martin, G F

    1998-05-01

    When the thoracic spinal cord of the North American opossum (Didelphis virginiana) is transected on postnatal day (PD) 5, the site of injury becomes bridged by histologically recognizable spinal cord and axons which form major long tracts grow through the lesion. In the present study we asked whether opossums lesioned on PD5 have normal use of the hindlimbs as adults and, if so, whether that use is dependent upon axons which grow through the lesion site. The thoracic spinal cord was transected on PD5 and 6 months later, hindlimb function was evaluated using the Basso, Beattie, and Bresnahan (BBB) locomotor scale. All animals supported their weight with the hindlimbs and used their hindlimbs normally during overground locomotion. In some cases, the spinal cord was retransected at the original lesion site or just caudal to it 6 months after the original transection and paralysis of the hindlimbs ensued. Surprisingly, however, these animals gradually recovered some ability to support their weight and to step with the hindlimbs. Similar recovery was not seen in animals transected only as adults. In order to verify that descending axons which grew through the lesion during development were still present in the adult animal, opossums subjected to transection of the thoracic cord on PD5 were reoperated and Fast blue was injected several segments caudal to the lesion. In all cases, neurons were labeled rostral to the lesion in each of the spinal and supraspinal nuclei labeled by comparable injections in unlesioned, age-matched controls. The results of orthograde tracing studies indicated that axons which grew through the lesion innervated areas that were appropriate for them. Copyright 1998 Academic Press.

  8. Longitudinal study on diffusion tensor imaging and diffusion tensor tractography following spinal cord contusion injury in rats.

    Science.gov (United States)

    Zhao, Can; Rao, Jia-Sheng; Pei, Xiao-Jiao; Lei, Jian-Feng; Wang, Zhan-Jing; Yang, Zhao-Yang; Li, Xiao-Guang

    2016-06-01

    Diffusion tensor imaging (DTI) as a potential technology has been used in spinal cord injury (SCI) studies, but the longitudinal evaluation of DTI parameters after SCI, and the correlation between DTI parameters and locomotor outcomes need to be defined. Adult Wistar rats (n = 6) underwent traumatic thoracic cord contusion by an NYU impactor. DTI and Basso-Beattie-Bresnahan datasets were collected pre-SCI and 1, 3, 7, 14, and 84 days post-SCI. Diffusion tensor tractography (DTT) of the spinal cord was also generated. Fractional anisotropy (FA) and connection rate of fibers at the injury epicenter and at 5 mm rostral/caudal to the epicenter were calculated. The variations of these parameters after SCI were observed by one-way analysis of variance and the correlations between these parameters and motor function were explored by Pearson's correlation. FA at the epicenter decreased most remarkably on day 1 post-SCI (from 0.780 ± 0.012 to 0.330 ± 0.015), and continued to decrease slightly by day 3 post-SCI (0.313 ± 0.015), while other parameters decreased significantly over the first 3 days after SCI. DTT showed residual fibers concentrated on ventral and ventrolateral sides of the cord. Moreover, FA at the epicenter exhibited the strongest correlation (r = 0.887, p = 0.000) with the locomotion performance. FA was sensitive to degeneration in white matter and DTT could directly reflect the distribution of the residual white matter. Moreover, days 1 to 3 post-SCI may be the optimal time window for SCI examination and therapy.

  9. Real-time direct measurement of spinal cord blood flow at the site of compression: relationship between blood flow recovery and motor deficiency in spinal cord injury.

    Science.gov (United States)

    Hamamoto, Yuichiro; Ogata, Tadanori; Morino, Tadao; Hino, Masayuki; Yamamoto, Haruyasu

    2007-08-15

    An in vivo study to measure rat spinal cord blood flow in real-time at the site of compression using a newly developed device. To evaluate the change in thoracic spinal cord blood flow by compression force and to clarify the association between blood flow recovery and motor deficiency after a spinal cord compression injury. Until now, no real-time measurement of spinal cord blood flow at the site of compression has been conducted. In addition, it has not been clearly determined whether blood flow recovery is related to motor function after a spinal cord injury. Our blood flow measurement system was a combination of a noncontact type laser Doppler system and a spinal cord compression device. The rat thoracic spinal cord was exposed at the 11th vertebra and spinal cord blood flow at the site of compression was continuously measured before, during, and after the compression. The functioning of the animal's hind-limbs was evaluated by the Basso, Beattie and Bresnahan scoring scale and the frequency of voluntary standing. Histologic changes such as permeability of blood-spinal cord barrier, microglia proliferation, and apoptotic cell death were examined in compressed spinal cord tissue. The spinal blood flow decreased on each increase in the compression force. After applying a 5-g weight, the blood flow decreased to compression), while no significant difference was observed between the 20-minute ischemia group and the sham group. In the 20-minute ischemia group, the rats whose spinal cord blood flow recovery was incomplete showed significant motor function loss compared with rats that completely recovered blood flow. Extensive breakdown of blood-spinal cord barrier integrity and the following microglia proliferation and apoptotic cell death were detected in the 40-minute complete ischemia group. Duration of ischemia/compression and blood flow recovery of the spinal cord are important factors in the recovery of motor function after a spinal cord injury.

  10. Methylprednisolone promotes recovery of neurological function after spinal cord injury: association with Wnt/β-catenin signaling pathway activation

    Science.gov (United States)

    Lu, Gong-biao; Niu, Fu-wen; Zhang, Ying-chun; Du, Lin; Liang, Zhi-yuan; Gao, Yuan; Yan, Ting-zhen; Nie, Zhi-kui; Gao, Kai

    2016-01-01

    Some studies have indicated that the Wnt/β-catenin signaling pathway is activated following spinal cord injury, and expression levels of specific proteins, including low-density lipoprotein receptor related protein-6 phosphorylation, β-catenin, and glycogen synthase kinase-3β, are significantly altered. We hypothesized that methylprednisolone treatment contributes to functional recovery after spinal cord injury by inhibiting apoptosis and activating the Wnt/β-catenin signaling pathway. In the current study, 30 mg/kg methylprednisolone was injected into rats with spinal cord injury immediately post-injury and at 1 and 2 days post-injury. Basso, Beattie, and Bresnahan scores showed that methylprednisolone treatment significantly promoted locomotor functional recovery between 2 and 6 weeks post-injury. The number of surviving motor neurons increased, whereas the lesion size significantly decreased following methylprednisolone treatment at 7 days post-injury. Additionally, caspase-3, caspase-9, and Bax protein expression levels and the number of apoptotic cells were reduced at 3 and 7 days post-injury, while Bcl-2 levels at 7 days post-injury were higher in methylprednisolone-treated rats compared with saline-treated rats. At 3 and 7 days post-injury, methylprednisolone up-regulated expression and activation of the Wnt/β-catenin signaling pathway, including low-density lipoprotein receptor related protein-6 phosphorylation, β-catenin, and glycogen synthase kinase-3β phosphorylation. These results indicate that methylprednisolone-induced neuroprotection may correlate with activation of the Wnt/β-catenin signaling pathway. PMID:28123427

  11. Objective measures of motor dysfunction after compression spinal cord injury in adult rats: correlations with locomotor rating scores.

    Science.gov (United States)

    Semler, Joerg; Wellmann, Katharina; Wirth, Felicitas; Stein, Gregor; Angelova, Srebrina; Ashrafi, Mahak; Schempf, Greta; Ankerne, Janina; Ozsoy, Ozlem; Ozsoy, Umut; Schönau, Eckhard; Angelov, Doychin N; Irintchev, Andrey

    2011-07-01

    Precise assessment of motor deficits after traumatic spinal cord injury (SCI) in rodents is crucial for understanding the mechanisms of functional recovery and testing therapeutic approaches. Here we analyzed the applicability to a rat SCI model of an objective approach, the single-frame motion analysis, created and used for functional analysis in mice. Adult female Wistar rats were subjected to graded compression of the spinal cord. Recovery of locomotion was analyzed using video recordings of beam walking and inclined ladder climbing. Three out of four parameters used in mice appeared suitable: the foot-stepping angle (FSA) and the rump-height index (RHI), measured during beam walking, and for estimating paw placement and body weight support, respectively, and the number of correct ladder steps (CLS), assessing skilled limb movements. These parameters, similar to the Basso, Beattie, and Bresnahan (BBB) locomotor rating scores, correlated with lesion volume and showed significant differences between moderately and severely injured rats at 1-9 weeks after SCI. The beam parameters, but not CLS, correlated well with the BBB scores within ranges of poor and good locomotor abilities. FSA co-varied with RHI only in the severely impaired rats, while RHI and CLS were barely correlated. Our findings suggest that the numerical parameters estimate, as intended by design, predominantly different aspects of locomotion. The use of these objective measures combined with BBB rating provides a time- and cost-efficient opportunity for versatile and reliable functional evaluations in both severely and moderately impaired rats, combining clinical assessment with precise numerical measures.

  12. Locomotor activity of rats with SCI is improved by dexmedetomidine by targeting the expression of inflammatory factors.

    Science.gov (United States)

    Wang, Wei-Guo; Wang, Lin; Jiao, Zhen-Hua; Xue, Bin; Xu, Zhan-Wang

    2018-04-26

    Dexmedetomidine, a well‑known selective α‑2 adrenoceptor agonist, inhibits the apoptosis of neurons and protects other organs from oxidative damage. In the present study, the effect of dexmedetomidine on spinal cord injury (SCI) in a rat model was investigated. The SCI rat model was prepared using the weight‑drop method, and the effect of dexmedetomidine on locomotor activity was analyzed using the Basso, Beattie and Bresnahan (BBB) rating scale. Western blot analysis was used to observe changes in the expression of apoptosis‑related proteins, including B‑cell lymphoma 2 (Bcl‑2) and Bcl‑2‑associated X protein (Bax). The results revealed that treatment of the SCI rats with dexmedetomidine at a dose of 50 mg/kg significantly prevented the formation of edema in the tissues of the spinal cord. Dexmedetomidine also inhibited the SCI‑induced accumulation of neutrophils in the spinal cord. The BBB scores were significantly increased (PSCI treated with dexmedetomidine after 10 days. The results of grid walking test revealed a marked decrease in the number of missteps following 10 days of dexmedetomidine treatment. The expression levels of tumor necrosis factor (TNF)‑α and interleukin (IL)‑1β were significantly reduced (PSCI exerted an inhibitory effect on the SCI‑induced increase in the expression of Bax. The expression of Bcl‑2 was increased in the dexmedetomidine treated rats, compared with that in the control group. Taken together, dexmedetomidine improved the locomotor activity of the rats through the inhibition of edema, reduction in the expression levels of TNF‑α and IL‑1β, and inhibition of the induction of apoptosis. Therefore, dexmedetomidine may be of therapeutic importance for patients with SCI.

  13. Valproic Acid Arrests Proliferation but Promotes Neuronal Differentiation of Adult Spinal NSPCs from SCI Rats.

    Science.gov (United States)

    Chu, Weihua; Yuan, Jichao; Huang, Lei; Xiang, Xin; Zhu, Haitao; Chen, Fei; Chen, Yanyan; Lin, Jiangkai; Feng, Hua

    2015-07-01

    Although the adult spinal cord contains a population of multipotent neural stem/precursor cells (NSPCs) exhibiting the potential to replace neurons, endogenous neurogenesis is very limited after spinal cord injury (SCI) because the activated NSPCs primarily differentiate into astrocytes rather than neurons. Valproic acid (VPA), a histone deacetylase inhibitor, exerts multiple pharmacological effects including fate regulation of stem cells. In this study, we cultured adult spinal NSPCs from chronic compressive SCI rats and treated with VPA. In spite of inhibiting the proliferation and arresting in the G0/G1 phase of NSPCs, VPA markedly promoted neuronal differentiation (β-tubulin III(+) cells) as well as decreased astrocytic differentiation (GFAP(+) cells). Cell cycle regulator p21(Cip/WAF1) and proneural genes Ngn2 and NeuroD1 were increased in the two processes respectively. In vivo, to minimize the possible inhibitory effects of VPA to the proliferation of NSPCs as well as avoid other neuroprotections of VPA in acute phase of SCI, we carried out a delayed intraperitoneal injection of VPA (150 mg/kg/12 h) to SCI rats from day 15 to day 22 after injury. Both of the newborn neuron marker doublecortin and the mature neuron marker neuron-specific nuclear protein were significantly enhanced after VPA treatment in the epicenter and adjacent segments of the injured spinal cord. Although the impaired corticospinal tracks had not significantly improved, Basso-Beattie-Bresnahan scores in VPA treatment group were better than control. Our study provide the first evidence that administration of VPA enhances the neurogenic potential of NSPCs after SCI and reveal the therapeutic value of delayed treatment of VPA to SCI.

  14. Macrophage depletion and Schwann cell transplantation reduce cyst size after rat contusive spinal cord injury

    Science.gov (United States)

    Lee, Yee-Shuan; Funk, Lucy H.; Lee, Jae K.; Bunge, Mary Bartlett

    2018-01-01

    Schwann cell transplantation is a promising therapy for the treatment of spinal cord injury (SCI) and is currently in clinical trials. In our continuing efforts to improve Schwann cell transplantation strategies, we sought to determine the combined effects of Schwann cell transplantation with macrophage depletion. Since macrophages are major inflammatory contributors to the acute spinal cord injury, and are the major phagocytic cells, we hypothesized that transplanting Schwann cells after macrophage depletion will improve cell survival and integration with host tissue after SCI. To test this hypothesis, rat models of contusive SCI at thoracic level 8 were randomly subjected to macrophage depletion or not. In rat subjected to macrophage depletion, liposomes filled with clodronate were intraperitoneally injected at 1, 3, 6, 11, and 18 days post injury. Rats not subjected to macrophage depletion were intraperitoneally injected with liposomes filled with phosphate buffered saline. Schwann cells were transplanted 1 week post injury in all rats. Biotinylated dextran amine (BDA) was injected at thoracic level 5 to evalute axon regeneration. The Basso, Beattie, and Bresnahan locomotor test, Gridwalk test, and sensory test using von Frey filaments were performed to assess functional recovery. Immunohistochemistry was used to detect glial fibrillary acidic protein, neurofilament, and green fluorescent protein (GFP), and also to visulize BDA-labelled axons. The GFP labeled Schwann cell and cyst and lesion volumes were quantified using stained slides. The numbers of BDA-positive axons were also quantified. At 8 weeks after Schwann cell transplantation, there was a significant reduction in cyst and lesion volumes in the combined treatment group compared to Schwann cell transplantation alone. These changes were not associated, however, with improved Schwann cell survival, axon growth, or locomotor recovery. Although combining Schwann cell transplantation with macrophage

  15. Macrophage depletion and Schwann cell transplantation reduce cyst size after rat contusive spinal cord injury

    Directory of Open Access Journals (Sweden)

    Yee-Shuan Lee

    2018-01-01

    Full Text Available Schwann cell transplantation is a promising therapy for the treatment of spinal cord injury (SCI and is currently in clinical trials. In our continuing efforts to improve Schwann cell transplantation strategies, we sought to determine the combined effects of Schwann cell transplantation with macrophage depletion. Since macrophages are major inflammatory contributors to the acute spinal cord injury, and are the major phagocytic cells, we hypothesized that transplanting Schwann cells after macrophage depletion will improve cell survival and integration with host tissue after SCI. To test this hypothesis, rat models of contusive SCI at thoracic level 8 were randomly subjected to macrophage depletion or not. In rat subjected to macrophage depletion, liposomes filled with clodronate were intraperitoneally injected at 1, 3, 6, 11, and 18 days post injury. Rats not subjected to macrophage depletion were intraperitoneally injected with liposomes filled with phosphate buffered saline. Schwann cells were transplanted 1 week post injury in all rats. Biotinylated dextran amine (BDA was injected at thoracic level 5 to evalute axon regeneration. The Basso, Beattie, and Bresnahan locomotor test, Gridwalk test, and sensory test using von Frey filaments were performed to assess functional recovery. Immunohistochemistry was used to detect glial fibrillary acidic protein, neurofilament, and green fluorescent protein (GFP, and also to visulize BDA-labelled axons. The GFP labeled Schwann cell and cyst and lesion volumes were quantified using stained slides. The numbers of BDA-positive axons were also quantified. At 8 weeks after Schwann cell transplantation, there was a significant reduction in cyst and lesion volumes in the combined treatment group compared to Schwann cell transplantation alone. These changes were not associated, however, with improved Schwann cell survival, axon growth, or locomotor recovery. Although combining Schwann cell transplantation with

  16. Down-regulated miR-448 relieves spinal cord ischemia/reperfusion injury by up-regulating SIRT1

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    Yun Wang

    2018-03-01

    Full Text Available MicroRNAs play a crucial role in the progression of spinal cord ischemia/reperfusion injury (SCII. The role of miR-448 and SIRT1 in SCII was investigated in this study, to provide further insights into prevention and improvement of this disorder. In this study, expressions of miR-448 and SIRT1 protein were determined by qRT-PCR and western blot, respectively. Flow cytometry was used to analyze cell apoptosis. The endogenous expression of genes was modulated by recombinant plasmids and cell transfection. Dual-luciferase reporter assay was performed to determine the interaction between miR-448 and SIRT1. The Basso, Beattie, and Bresnahan score was used to measure the hind-limb function of rat. The spinal cord ischemia reperfusion injury model of adult rats was developed by abdominal aorta clamping, and the nerve function evaluation was completed by motor deficit index score. In SCII tissues and cells treated with hypoxia, miR-448 was up-regulated while SIRT1 was down-regulated. Hypoxia treatment reduced the expression of SIRT1 through up-regulating miR-448 in nerve cells. Up-regulation of miR-448 induced by hypoxia promoted apoptosis of nerve cells through down-regulating SIRT1. Down-regulated miR-448 improved neurological function and hind-limb motor function of rats with SCII by up-regulating SIRT1. Down-regulated miR-448 inhibited apoptosis of nerve cells and improved neurological function by up-regulating SIRT1, which contributes to relieving SCII.

  17. Combination of edaravone and neural stem cell transplantation repairs injured spinal cord in rats.

    Science.gov (United States)

    Song, Y Y; Peng, C G; Ye, X B

    2015-12-29

    This study sought to observe the effect of the combination of edaravone and neural stem cell (NSC) transplantation on the repair of complete spinal cord transection in rats. Eighty adult female Sprague-Dawley (SD) rats were used to establish the injury model of complete spinal cord transection at T9. Animals were divided randomly into four groups (N = 20 each): control, edaravone, transplantation, and edaravone + transplantation. The recovery of spinal function was evaluated with the Basso, Beattie, Bresnahan (BBB) rating scale on days 1, 3, and 7 each week after the surgery. After 8 weeks, the BBB scores of the control, edaravone, transplantation, and combination groups were 4.21 ± 0.11, 8.46 ± 0.1, 8.54 ± 0.13, and 11.21 ± 0.14, respectively. At 8 weeks after surgery, the spinal cord was collected; the survival and transportation of transplanted cells were observed with PKH-26 labeling, and the regeneration and distribution of spinal nerve fibers with fluorescent-gold (FG) retrograde tracing. Five rats died due to the injury. PKH-26-labeled NSCs had migrated into the spinal cord. A few intact nerve fibers and pyramidal neurons passed the injured area in the transplantation and combination groups. The numbers of PKH-26-labeled cells and FG-labeled nerve fibers were in the order: combination group > edaravone group and transplantation group > control group (P edaravone can enhance the survival and differentiation of NSCs in injured areas; edaravone with NSC transplantation can improve the effectiveness of spinal cord injury repair in rats.

  18. Assessment of the Neuroprotective Effects of Lavandula angustifolia Extract on the Contusive Model of Spinal Cord Injury in Wistar Rats

    Science.gov (United States)

    Kaka, Gholamreza; Yaghoobi, Kayvan; Davoodi, Shaghayegh; Hosseini, Seyed R.; Sadraie, Seyed H.; Mansouri, Korosh

    2016-01-01

    Introduction: Spinal cord injury (SCI) involves a primary trauma and secondary cellular processes that can lead to severe damage to the nervous system, resulting in long-term spinal deficits. At the cellular level, SCI causes astrogliosis, of which glial fibrillary acidic protein (GFAP) is a major index. Objective: The aim of this study was to investigate the neuroprotective effects of Lavandula angustifolia (Lav) on the repair of spinal cord injuries in Wistar rats. Materials and Methods: Forty-five female rats were randomly divided into six groups of seven rats each: the intact, sham, control (SCI), Lav 100, Lav 200, and Lav 400 groups. Every week after SCI onset, all animals were evaluated for behavior outcomes by the Basso, Beattie, and Bresnahan (BBB) score. H&E staining was performed to examine the lesions post-injury. GFAP expression was assessed for astrogliosis. Somatosensory evoked potential (SEP) testing was performed to detect the recovery of neural conduction. Results: BBB scores were significantly increased and delayed responses on sensory tests were significantly decreased in the Lav 200 and Lav 400 groups compared to the control group. The greatest decrease of GFAP was evident in the Lav 200 and Lav 400 groups. EMG results showed significant improvement in the hindlimbs in the Lav 200 and Lav 400 groups compared to the control group. Cavity areas significantly decreased and the number of ventral motor neurons significantly increased in the Lav 200 and Lav 400 groups. Conclusion: Lav at doses of 200 and 400 mg/kg can promote structural and functional recovery after SCI. The neuroprotective effects of L. angustifolia can lead to improvement in the contusive model of SCI in Wistar rats. PMID:26903793

  19. Effect of melatonin on the functional recovery from experimental traumatic compression of the spinal cord

    International Nuclear Information System (INIS)

    Schiaveto-de-Souza, A.; Silva, C.A. da; Defino, H.L.A.; Bel, E.A.Del

    2013-01-01

    Spinal cord injury is an extremely severe condition with no available effective therapies. We examined the effect of melatonin on traumatic compression of the spinal cord. Sixty male adult Wistar rats were divided into three groups: sham-operated animals and animals with 35 and 50% spinal cord compression with a polycarbonate rod spacer. Each group was divided into two subgroups, each receiving an injection of vehicle or melatonin (2.5 mg/kg, intraperitoneal) 5 min prior to and 1, 2, 3, and 4 h after injury. Functional recovery was monitored weekly by the open-field test, the Basso, Beattie and Bresnahan locomotor scale and the inclined plane test. Histological changes of the spinal cord were examined 35 days after injury. Motor scores were progressively lower as spacer size increased according to the motor scale and inclined plane test evaluation at all times of assessment. The results of the two tests were correlated. The open-field test presented similar results with a less pronounced difference between the 35 and 50% compression groups. The injured groups presented functional recovery that was more evident in the first and second weeks. Animals receiving melatonin treatment presented more pronounced functional recovery than vehicle-treated animals as measured by the motor scale or inclined plane. NADPH-d histochemistry revealed integrity of the spinal cord thoracic segment in sham-operated animals and confirmed the severity of the lesion after spinal cord narrowing. The results obtained after experimental compression of the spinal cord support the hypothesis that melatonin may be considered for use in clinical practice because of its protective effect on the secondary wave of neuronal death following the primary wave after spinal cord injury

  20. Effects of estrogen on functional and neurological recovery after spinal cord injury: An experimental study with rats

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    Olavo Biraghi Letaif

    2015-10-01

    Full Text Available OBJECTIVES:To evaluate the functional and histological effects of estrogen as a neuroprotective agent after a standard experimentally induced spinal cord lesion.METHODS:In this experimental study, 20 male Wistar rats were divided into two groups: one group with rats undergoing spinal cord injury (SCI at T10 and receiving estrogen therapy with 17-beta estradiol (4mg/kg immediately following the injury and after the placement of skin sutures and a control group with rats only subjected to SCI. A moderate standard experimentally induced SCI was produced using a computerized device that dropped a weight on the rat's spine from a height of 12.5 mm. Functional recovery was verified with the Basso, Beattie and Bresnahan scale on the 2nd, 7th, 14th, 21st, 28th, 35th and 42nd days after injury and by quantifying the motor-evoked potential on the 42nd day after injury. Histopathological evaluation of the SCI area was performed after euthanasia on the 42nd day.RESULTS:The experimental group showed a significantly greater functional improvement from the 28th to the 42nd day of observation compared to the control group. The experimental group showed statistically significant improvements in the motor-evoked potential compared with the control group. The results of pathological histomorphometry evaluations showed a better neurological recovery in the experimental group, with respect to the proportion and diameter of the quantified nerve fibers.CONCLUSIONS:Estrogen administration provided benefits in neurological and functional motor recovery in rats with SCI beginning at the 28th day after injury.

  1. Effects of estrogen on functional and neurological recovery after spinal cord injury: An experimental study with rats.

    Science.gov (United States)

    Letaif, Olavo Biraghi; Cristante, Alexandre Fogaça; Barros Filho, Tarcísio Eloy Pessoa de; Ferreira, Ricardo; Santos, Gustavo Bispo dos; Rocha, Ivan Dias da; Marcon, Raphael Martus

    2015-10-01

    To evaluate the functional and histological effects of estrogen as a neuroprotective agent after a standard experimentally induced spinal cord lesion. In this experimental study, 20 male Wistar rats were divided into two groups: one group with rats undergoing spinal cord injury (SCI) at T10 and receiving estrogen therapy with 17-beta estradiol (4mg/kg) immediately following the injury and after the placement of skin sutures and a control group with rats only subjected to SCI. A moderate standard experimentally induced SCI was produced using a computerized device that dropped a weight on the rat's spine from a height of 12.5 mm. Functional recovery was verified with the Basso, Beattie and Bresnahan scale on the 2nd, 7th, 14th, 21st, 28th, 35th and 42nd days after injury and by quantifying the motor-evoked potential on the 42nd day after injury. Histopathological evaluation of the SCI area was performed after euthanasia on the 42nd day. The experimental group showed a significantly greater functional improvement from the 28th to the 42nd day of observation compared to the control group. The experimental group showed statistically significant improvements in the motor-evoked potential compared with the control group. The results of pathological histomorphometry evaluations showed a better neurological recovery in the experimental group, with respect to the proportion and diameter of the quantified nerve fibers. Estrogen administration provided benefits in neurological and functional motor recovery in rats with SCI beginning at the 28th day after injury.

  2. Exendin-4 Plays a Protective Role in a Rat Model of Spinal Cord Injury Through SERCA2

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    Zhonglei Sun

    2018-05-01

    Full Text Available Background/Aims: Current therapies for spinal cord injury (SCI have limited efficacy, and identifying a therapeutic target is a pressing need. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2 plays an important role in regulating calcium homeostasis, which has been shown to inhibit apoptosis. Exendin-4 has been shown to inhibit the apoptosis of nerve cells in SCI, which can also improve SERCA2 expression. In this study, we sought to determine whether exendin-4 plays a protective role in a rat model of SCI via SERCA2. Methods: To investigate the effects of exendin-4 on SCI, a rat model of SCI was induced by a modified version of Allen’s method. Spinal cord tissue sections from rats and western blot analysis were used to examine SERCA2 expression after treatment with the long-acting glucagon-like peptide 1 receptor exendin-4 or the SERCA2 antagonist 5(6-carboxyfluorescein diacetate N-succinimidyl ester (CE. Locomotor function was evaluated using the Basso Beattie Bresnahan locomotor rating scale and slanting board test. Results: Cell apoptosis was increased with CE treatment and decreased with exendin-4 treatment. Upregulation of SERCA2 in female rats with SCI resulted in an improvement of motor function scores and histological changes. Conclusion: These findings suggest that exendin-4 plays a protective role in a rat model of SCI through SERCA2 via inhibition of apoptosis. Existing drugs targeting SERCA2 may be an effective therapeutic strategy for the treatment of SCI.

  3. Effect of melatonin on the functional recovery from experimental traumatic compression of the spinal cord

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    A. Schiaveto-de-Souza

    2013-12-01

    Full Text Available Spinal cord injury is an extremely severe condition with no available effective therapies. We examined the effect of melatonin on traumatic compression of the spinal cord. Sixty male adult Wistar rats were divided into three groups: sham-operated animals and animals with 35 and 50% spinal cord compression with a polycarbonate rod spacer. Each group was divided into two subgroups, each receiving an injection of vehicle or melatonin (2.5 mg/kg, intraperitoneal 5 min prior to and 1, 2, 3, and 4 h after injury. Functional recovery was monitored weekly by the open-field test, the Basso, Beattie and Bresnahan locomotor scale and the inclined plane test. Histological changes of the spinal cord were examined 35 days after injury. Motor scores were progressively lower as spacer size increased according to the motor scale and inclined plane test evaluation at all times of assessment. The results of the two tests were correlated. The open-field test presented similar results with a less pronounced difference between the 35 and 50% compression groups. The injured groups presented functional recovery that was more evident in the first and second weeks. Animals receiving melatonin treatment presented more pronounced functional recovery than vehicle-treated animals as measured by the motor scale or inclined plane. NADPH-d histochemistry revealed integrity of the spinal cord thoracic segment in sham-operated animals and confirmed the severity of the lesion after spinal cord narrowing. The results obtained after experimental compression of the spinal cord support the hypothesis that melatonin may be considered for use in clinical practice because of its protective effect on the secondary wave of neuronal death following the primary wave after spinal cord injury.

  4. Effect of melatonin on the functional recovery from experimental traumatic compression of the spinal cord

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    Schiaveto-de-Souza, A. [Departamento de Morfofisiologia, Universidade Federal do Mato Grosso do Sul, Campo Grande, MS (Brazil); Silva, C.A. da [Departamento de Morfologia,Estomatologia e Fisiologia, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Defino, H.L.A. [Departamento de Orthopedia e Traumatologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Bel, E.A.Del [Departamento de Morfologia,Estomatologia e Fisiologia, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil)

    2013-04-12

    Spinal cord injury is an extremely severe condition with no available effective therapies. We examined the effect of melatonin on traumatic compression of the spinal cord. Sixty male adult Wistar rats were divided into three groups: sham-operated animals and animals with 35 and 50% spinal cord compression with a polycarbonate rod spacer. Each group was divided into two subgroups, each receiving an injection of vehicle or melatonin (2.5 mg/kg, intraperitoneal) 5 min prior to and 1, 2, 3, and 4 h after injury. Functional recovery was monitored weekly by the open-field test, the Basso, Beattie and Bresnahan locomotor scale and the inclined plane test. Histological changes of the spinal cord were examined 35 days after injury. Motor scores were progressively lower as spacer size increased according to the motor scale and inclined plane test evaluation at all times of assessment. The results of the two tests were correlated. The open-field test presented similar results with a less pronounced difference between the 35 and 50% compression groups. The injured groups presented functional recovery that was more evident in the first and second weeks. Animals receiving melatonin treatment presented more pronounced functional recovery than vehicle-treated animals as measured by the motor scale or inclined plane. NADPH-d histochemistry revealed integrity of the spinal cord thoracic segment in sham-operated animals and confirmed the severity of the lesion after spinal cord narrowing. The results obtained after experimental compression of the spinal cord support the hypothesis that melatonin may be considered for use in clinical practice because of its protective effect on the secondary wave of neuronal death following the primary wave after spinal cord injury.

  5. Dental Apical Papilla as Therapy for Spinal Cord Injury.

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    De Berdt, P; Vanacker, J; Ucakar, B; Elens, L; Diogenes, A; Leprince, J G; Deumens, R; des Rieux, A

    2015-11-01

    Stem cells of the apical papilla (SCAP) represent great promise regarding treatment of neural tissue damage, such as spinal cord injury (SCI). They derive from the neural crest, express numerous neurogenic markers, and mediate neurite outgrowth and axonal targeting. The goal of the present work was to investigate for the first time their potential to promote motor recovery after SCI in a rat hemisection model when delivered in their original stem cell niche-that is, by transplantation of the human apical papilla tissue itself into the lesion. Control groups consisted of animals subjected to laminectomy only (shams) and to lesion either untreated or injected with a fibrin hydrogel with or without human SCAP. Basso-Beattie-Bresnahan locomotor scores at 1 and 3 d postsurgery confirmed early functional decline in all SCI groups. This significant impairment was reversed, as seen in CatWalk analyses, after transplantation of apical papilla into the injured spinal cord wound, whereas the other groups demonstrated persistent functional impairment. Moreover, tactile allodynia did not develop as an unwanted side effect in any of the groups, even though the SCAP hydrogel group showed higher expression of the microglial marker Iba-1, which has been frequently associated with allodynia. Notably, the apical papilla transplant group presented with reduced Iba-1 expression level. Masson trichrome and human mitochondria staining showed the preservation of the apical papilla integrity and the presence of numerous human cells, while human cells could no longer be detected in the SCAP hydrogel group at the 6-wk postsurgery time point. Altogether, our data suggest that the transplantation of a human apical papilla at the lesion site improves gait in spinally injured rats and reduces glial reactivity. It also underlines the potential interest for the application of delivering SCAP in their original niche, as compared with use of a fibrin hydrogel. © International & American

  6. Serial Diffusion Tensor Imaging In Vivo Predicts Long-Term Functional Recovery and Histopathology in Rats following Different Severities of Spinal Cord Injury

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    Patel, Samir P.; Smith, Taylor D.; VanRooyen, Jenna L.; Powell, David; Cox, David H.; Sullivan, Patrick G.

    2016-01-01

    Abstract The current study demonstrates the feasibility of using serial magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) in vivo to quantify temporally spinal cord injury (SCI) pathology in adult female Sprague-Dawley rats that were scanned prior to a moderate or severe upper lumbar contusion SCI. Injured rats were behaviorally tested for hind limb locomotion (Basso, Beattie, Bresnahan [BBB] scores) weekly for 4 weeks and scanned immediately after each session, ending with terminal gait analyses prior to euthanasia. As a measure of tissue integrity, fractional anisotropy (FA) values were significantly lower throughout the spinal cord in both injury cohorts at all time-points examined versus pre-injury. Moreover, FA values were significantly lower following severe versus moderate SCI at all time-points, and FA values at the injury epicenters at all time-points were significantly correlated with both spared white and gray matter volumes, as well as lesion volumes. Critically, quantified FA values at subacute (24 h) and all subsequent time-points were highly predictive of terminal behavior, reflected in significant correlations with both weekly BBB scores and terminal gait parameters. Critically, the finding that clinically relevant subacute (24 h) FA values accurately predict long-term functional recovery may obviate long-term studies to assess the efficacy of therapeutics tested experimentally or clinically. In summary, this study demonstrates a reproducible serial MRI procedure to predict the long-term impact of contusion SCI on both behavior and histopathology using subacute DTI metrics obtained in vivo to accurately predict multiple terminal outcome measures, which can be particularly valuable when comparing experimental interventions. PMID:26650623

  7. Neuroprotective effects of Ganoderma lucidum polysaccharides against traumatic spinal cord injury in rats.

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    Gokce, Emre Cemal; Kahveci, Ramazan; Atanur, Osman Malik; Gürer, Bora; Aksoy, Nurkan; Gokce, Aysun; Sargon, Mustafa Fevzi; Cemil, Berker; Erdogan, Bulent; Kahveci, Ozan

    2015-11-01

    Ganoderma lucidum (G. lucidum) is a mushroom belonging to the polyporaceae family of Basidiomycota and has widely been used as a traditional medicine for thousands of years. G. lucidum has never been studied in traumatic spinal cord injury. The aim of this study is to investigate whether G. lucidum polysaccharides (GLPS) can protect the spinal cord after experimental spinal cord injury. Rats were randomized into five groups of eight animals each: control, sham, trauma, GLPS, and methylprednisolone. In the control group, no surgical intervention was performed. In the sham group, only a laminectomy was performed. In all the other groups, the spinal cord trauma model was created by the occlusion of the spinal cord with an aneurysm clip. In the spinal cord tissue, caspase-3 activity, tumour necrosis factor-alpha levels, myeloperoxidase activity, malondialdehyde levels, nitric oxide levels, and superoxide dismutase levels were analysed. Histopathological and ultrastructural evaluations were also performed. Neurological evaluation was performed using the Basso, Beattie, and Bresnahan locomotor scale and the inclined-plane test. After traumatic spinal cord injury, increases in caspase-3 activity, tumour necrosis factor-alpha levels, myeloperoxidase activity, malondialdehyde levels, and nitric oxide levels were detected. After the administration of GLPS, decreases were observed in tissue caspase-3 activity, tumour necrosis factor-alpha levels, myeloperoxidase activity, malondialdehyde levels, and nitric oxide levels. Furthermore, GLPS treatment showed improved results in histopathological scores, ultrastructural scores, and functional tests. Biochemical, histopathological, and ultrastructural analyses and functional tests reveal that GLPS exhibits meaningful neuroprotective effects against spinal cord injury. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Epidermal growth factor regulates apoptosis and oxidative stress in a rat model of spinal cord injury.

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    Ozturk, Anil Murat; Sozbilen, Murat Celal; Sevgili, Elvin; Dagci, Taner; Özyalcin, Halit; Armagan, Guliz

    2018-03-22

    Spinal cord injury (SCI) leads to vascular damage and disruption of blood-spinal cord barrier which participates in secondary nerve injury. Epidermal growth factor (EGF) is an endogenous protein which regulates cell proliferation, growth and differention. Previous studies reported that EGF exerts neuroprotective effect in spinal cord after SCI. However, the molecular mechanisms underlying EGF-mediated protection in different regions of nervous system have not shown yet. In this study, we aimed to examine possible anti-apoptotic and protective roles of EGF not only in spinal cord but also in brain following SCI. Twenty-eight adult rats were divided into four groups of seven animals each as follows: sham, trauma (SCI), SCI + EGF and SCI + methylprednisolone (MP) groups. The functional neurological deficits due to the SCI were assessed by behavioral analysis using the Basso, Beattie and Bresnahan (BBB) open-field locomotor test. The alterations in pro-/anti-apoptotic protein levels and antioxidant enzyme activities were measured in spinal cord and frontal cortex. In our study, EGF promoted locomotor recovery and motor neuron survival of SCI rats. EGF treatment significantly decreased Bax and increased Bcl-2 protein expressions both in spinal cord and brain when compared to SCI group. Moreover, antioxidant enzyme activities including catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) were increased following EGF treatment similar to MP treatment. Our experiment also suggests that alteration of the ratio of Bcl-2 to Bax may result from decreased apoptosis following EGF treatment. As a conclusion, these results show, for the first time, that administration of EGF exerts its protection via regulating apoptotic and oxidative pathways in response to spinal cord injury in different regions of central nervous system. Copyright © 2018 Elsevier Ltd. All rights reserved.

  9. Curcumin Increase the Expression of Neural Stem/Progenitor Cells and Improves Functional Recovery after Spinal Cord Injury

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    Bang, Woo-Seok; Kim, Kyoung-Tae; Seo, Ye Jin; Cho, Dae-Chul; Sung, Joo-Kyung; Kim, Chi Heon

    2018-01-01

    Objective To investigates the effect of curcumin on proliferation of spinal cord neural stem/progenitor cells (SC-NSPCs) and functional outcome in a rat spinal cord injury (SCI) model. Methods Sixty adult male Sprague-Dawley rats were randomly and blindly allocated into three groups (sham control group; curcumin treated group after SCI; vehicle treated group after SCI). Functional recovery was evaluated by the Basso, Beattie, and Bresnahan (BBB) scale during 6 weeks after SCI. The expression of SC-NSPC proliferation and astrogliosis were analyzed by nestin/Bromodeoxyuridine (BrdU) and Glial fibrillary acidic protein (GFAP) staining. The injured spinal cord was then examined histologically, including quantification of cavitation. Results The BBB score of the SCI-curcumin group was better than that of SCI-vehicle group up to 14 days (p<0.05). The co-immunoreactivity of nestin/BrdU in the SCI-curcumin group was much higher than that of the SCI-vehicle group 1 week after surgery (p<0.05). The GFAP immunoreactivity of the SCI-curcumin group was remarkably lower than that of the SCI-vehicle group 4 weeks after surgery (p<0.05). The lesion cavity was significantly reduced in the curcumin group as compared to the control group (p<0.05). Conclusion These results indicate that curcumin could increase the expression of SC-NSPCs, and reduce the activity of reactive astrogliosis and lesion cavity. Consequently curcumin could improve the functional recovery after SCI via SC-NSPC properties. PMID:29354231

  10. A 3D nanofibrous hydrogel and collagen sponge scaffold promotes locomotor functional recovery, spinal repair, and neuronal regeneration after complete transection of the spinal cord in adult rats

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    Kaneko, Ai; Matsushita, Akira; Sankai, Yoshiyuki

    2015-01-01

    Central nervous system neurons in adult mammals display limited regeneration after injury, and functional recovery is poor following complete transection (>4 mm gap) of a rat spinal cord. A novel combination scaffold composed of 3D nanofibrous hydrogel PuraMatrix and a honeycomb collagen sponge was used to promote spinal repair and locomotor functional recovery following complete transection of the spinal cord in rats. We transplanted this scaffold into 5 mm spinal cord gaps and assessed spinal repair and functional recovery using the Basso, Beattie, and Bresnahan (BBB) locomotor scale. The BBB score of the scaffold-transplanted group was significantly higher than that of the PBS-injected control group from 24 d to 4 months after the operation (P < 0.001–0.01), reaching 6.0  ±  0.75 (mean ± SEM) in the transplant and 0.70  ±  0.46 in the control groups. Neuronal regeneration and spinal repair were examined histologically using Pan Neuronal Marker, glial fibrillary acidic protein, growth-associated protein 43, and DAPI. The scaffolds were well integrated into the spinal cords, filling the 5 mm gaps with higher numbers of regenerated and migrated neurons, astrocytes, and other cells than in the control group. Mature and immature neurons and astrocytes in the scaffolds became colocalized and aligned longitudinally over >2 mm, suggesting their differentiation, maturation, and function. The spinal cord NF200 content of the transplant group, analyzed by western blot, was more than twice that of the control group, supporting the histological results. Transplantation of this novel scaffold promoted functional recovery, spinal repair, and neuronal regeneration. (paper)

  11. Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury?

    Directory of Open Access Journals (Sweden)

    Jiri Ruzicka

    2018-01-01

    Full Text Available Systematic inflammatory response after spinal cord injury (SCI is one of the factors leading to lesion development and a profound degree of functional loss. Anti-inflammatory compounds, such as curcumin and epigallocatechin gallate (EGCG are known for their neuroprotective effects. In this study, we investigated the effect of combined therapy of curcumin and EGCG in a rat model of acute SCI induced by balloon compression. Immediately after SCI, rats received curcumin, EGCG, curcumin + EGCG or saline [daily intraperitoneal doses (curcumin, 6 mg/kg; EGCG 17 mg/kg] and weekly intramuscular doses (curcumin, 60 mg/kg; EGCG 17 mg/kg] for 28 days. Rats were evaluated using behavioral tests (the Basso, Beattie, and Bresnahan (BBB open-field locomotor test, flat beam test. Spinal cord tissue was analyzed using histological methods (Luxol Blue-cresyl violet staining and immunohistochemistry (anti-glial fibrillary acidic protein, anti-growth associated protein 43. Cytokine levels (interleukin-1β, interleukin-4, interleukin-2, interleukin-6, macrophage inflammatory protein 1-alpha, and RANTES were measured using Luminex assay. Quantitative polymerase chain reaction was performed to determine the relative expression of genes (Sort1, Fgf2, Irf5, Mrc1, Olig2, Casp3, Gap43, Gfap, Vegf, NfκB, Cntf related to regenerative processes in injured spinal cord. We found that all treatments displayed significant behavioral recovery, with no obvious synergistic effect after combined therapy of curcumin and ECGC. Curcumin and EGCG alone or in combination increased axonal sprouting, decreased glial scar formation, and altered the levels of macrophage inflammatory protein 1-alpha, interleukin-1β, interleukin-4 and interleukin-6 cytokines. These results imply that although the expected synergistic response of this combined therapy was less obvious, aspects of tissue regeneration and immune responses in severe SCI were evident.

  12. Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury?

    Science.gov (United States)

    Ruzicka, Jiri; Urdzikova, Lucia Machova; Svobodova, Barbora; Amin, Anubhav G; Karova, Kristyna; Dubisova, Jana; Zaviskova, Kristyna; Kubinova, Sarka; Schmidt, Meic; Jhanwar-Uniyal, Meena; Jendelova, Pavla

    2018-01-01

    Systematic inflammatory response after spinal cord injury (SCI) is one of the factors leading to lesion development and a profound degree of functional loss. Anti-inflammatory compounds, such as curcumin and epigallocatechin gallate (EGCG) are known for their neuroprotective effects. In this study, we investigated the effect of combined therapy of curcumin and EGCG in a rat model of acute SCI induced by balloon compression. Immediately after SCI, rats received curcumin, EGCG, curcumin + EGCG or saline [daily intraperitoneal doses (curcumin, 6 mg/kg; EGCG 17 mg/kg)] and weekly intramuscular doses (curcumin, 60 mg/kg; EGCG 17 mg/kg)] for 28 days. Rats were evaluated using behavioral tests (the Basso, Beattie, and Bresnahan (BBB) open-field locomotor test, flat beam test). Spinal cord tissue was analyzed using histological methods (Luxol Blue-cresyl violet staining) and immunohistochemistry (anti-glial fibrillary acidic protein, anti-growth associated protein 43). Cytokine levels (interleukin-1β, interleukin-4, interleukin-2, interleukin-6, macrophage inflammatory protein 1-alpha, and RANTES) were measured using Luminex assay. Quantitative polymerase chain reaction was performed to determine the relative expression of genes (Sort1, Fgf2, Irf5, Mrc1, Olig2, Casp3, Gap43, Gfap, Vegf, NfκB, Cntf) related to regenerative processes in injured spinal cord. We found that all treatments displayed significant behavioral recovery, with no obvious synergistic effect after combined therapy of curcumin and ECGC. Curcumin and EGCG alone or in combination increased axonal sprouting, decreased glial scar formation, and altered the levels of macrophage inflammatory protein 1-alpha, interleukin-1β, interleukin-4 and interleukin-6 cytokines. These results imply that although the expected synergistic response of this combined therapy was less obvious, aspects of tissue regeneration and immune responses in severe SCI were evident.

  13. Nerve growth factor delivery by ultrasound-mediated nanobubble destruction as a treatment for acute spinal cord injury in rats

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    Song, Zhaojun; Wang, Zhigang; Shen, Jieliang; Xu, Shengxi; Hu, Zhenming

    2017-01-01

    Background Spinal cord injuries (SCIs) can cause severe disability or death. Treatment options include surgical intervention, drug therapy, and stem cell transplantation. However, the efficacy of these methods for functional recovery remains unsatisfactory. Purpose This study was conducted to explore the effect of ultrasound (US)-mediated destruction of poly(lactic-co-glycolic acid) (PLGA) nanobubbles (NBs) expressing nerve growth factor (NGF) (NGF/PLGA NBs) on nerve regeneration in rats following SCI. Materials and methods Adult male Sprague Dawley rats were randomly divided into four treatment groups after Allen hit models of SCI were established. The groups were normal saline (NS) group, NGF and NBs group, NGF and US group, and NGF/PLGA NBs and US group. Histological changes after SCI were observed by hematoxylin and eosin staining. Neuron viability was determined by Nissl staining. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling staining was used to examine cell apoptosis. NGF gene and protein expressions were detected by quantitative reverse transcription polymerase chain reaction and Western blotting. Green fluorescent protein expression in the spinal cord was examined using an inverted fluorescence microscope. The recovery of neural function was determined using the Basso, Beattie, and Bresnahan test. Results NGF therapy using US-mediated NGF/PLGA NBs destruction significantly increased NGF expression, attenuated histological injury, decreased neuron loss, inhibited neuronal apoptosis in injured spinal cords, and increased BBB scores in rats with SCI. Conclusion US-mediated NGF/PLGA NBs destruction effectively transfects the NGF gene into target tissues and has a significant effect on the injured spinal cord. The combination of US irradiation and gene therapy through NGF/PLGA NBs holds great promise for the future of nanomedicine and the development of noninvasive treatment options for SCI and other diseases. PMID:28280337

  14. Evaluation of early and late effects into the acute spinal cord injury of an injectable functionalized self-assembling scaffold.

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    Daniela Cigognini

    Full Text Available The complex physiopathological events occurring after spinal cord injury (SCI make this devastating trauma still incurable. Self-assembling peptides (SAPs are nanomaterials displaying some appealing properties for application in regenerative medicine because they mimic the structure of the extra-cellular matrix (ECM, are reabsorbable, allow biofunctionalizations and can be injected directly into the lesion. In this study we evaluated the putative neurorigenerative properties of RADA16-4G-BMHP1 SAP, proved to enhance in vitro neural stem cells survival and differentiation. This SAP (RADA16-I has been functionalized with a bone marrow homing motif (BMHP1 and optimized via the insertion of a 4-glycine-spacer that ameliorates scaffold stability and exposure of the biomotifs. We injected the scaffold immediately after contusion in the rat spinal cord, then we evaluated the early effects by semi-quantitative RT-PCR and the late effects by histological analysis. Locomotor recovery over 8 weeks was assessed using Basso, Beattie, Bresnahan (BBB test. Gene expression analysis showed that at 7 days after lesion the functionalized SAP induced a general upregulation of GAP-43, trophic factors and ECM remodelling proteins, whereas 3 days after SCI no remarkable changes were observed. Hystological analysis revealed that 8 weeks after SCI our scaffold increased cellular infiltration, basement membrane deposition and axon regeneration/sprouting within the cyst. Moreover the functionalized SAP showed to be compatible with the surrounding nervous tissue and to at least partially fill the cavities. Finally SAP injection resulted in a statistically significant improvement of both hindlimbs' motor performance and forelimbs-hindlimbs coordination. Altogether, these results indicate that RADA16-4G-BMHP1 induced favourable reparative processes, such as matrix remodelling, and provided a physical and trophic support to nervous tissue ingrowth. Thus this biomaterial

  15. Effect of transplantation of olfactory ensheathing cell conditioned medium induced bone marrow stromal cells on rats with spinal cord injury

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    Feng, Linjie; Gan, Hongquan; Zhao, Wenguo; Liu, Yingjie

    2017-01-01

    Spinal cord injury is a serious threat to human health and various techniques have been deployed to ameliorate or cure its effects. Stem cells transplantation is one of the promising methods. The primary aim of the present study was to investigate the effect of the transplantation of olfactory ensheathing cell (OEC) conditioned medium-induced bone marrow stromal cells (BMSCs) on spinal cord injury. Rat spinal cord compression injury animal models were generated, and the rats divided into the following three groups: Group A, (control) Dulbecco's modified Eagle's medium-treated group; group B, normal BMSC-treated group; group C, OEC conditioned medium-induced BMSC-treated group. The animals were sacrificed at 2, 4 and 8 weeks following transplantation for hematoxylin and eosin staining, and fluorescence staining of neurofilament protein, growth associated protein-43 and neuron-specific nuclear protein. The cavity area of the spinal cord injury was significantly reduced at 2 and 4 weeks following transplantation in group C, and a significant difference between the Basso, Beattie and Bresnahan score in group C and groups A and B was observed. Regenerated nerve fibers were observed in groups B and C; however, a greater number of regenerated nerve fibers were observed in group C. BMSCs induced by OEC conditioned medium survived in vivo, significantly reduced the cavity area of spinal cord injury, promoted nerve fiber regeneration following spinal cord injury and facilitated recovery of motor function. The present study demonstrated a novel method to repair spinal cord injury by using induced BMSCs, with satisfactory results. PMID:28656221

  16. Effect of electrical stimulation on neural regeneration via the p38-RhoA and ERK1/2-Bcl-2 pathways in spinal cord-injured rats.

    Science.gov (United States)

    Joo, Min Cheol; Jang, Chul Hwan; Park, Jong Tae; Choi, Seung Won; Ro, Seungil; Kim, Min Seob; Lee, Moon Young

    2018-02-01

    Although electrical stimulation is therapeutically applied for neural regeneration in patients, it remains unclear how electrical stimulation exerts its effects at the molecular level on spinal cord injury (SCI). To identify the signaling pathway involved in electrical stimulation improving the function of injured spinal cord, 21 female Sprague-Dawley rats were randomly assigned to three groups: control (no surgical intervention, n = 6), SCI (SCI only, n = 5), and electrical simulation (ES; SCI induction followed by ES treatment, n = 10). A complete spinal cord transection was performed at the 10 th thoracic level. Electrical stimulation of the injured spinal cord region was applied for 4 hours per day for 7 days. On days 2 and 7 post SCI, the Touch-Test Sensory Evaluators and the Basso-Beattie-Bresnahan locomotor scale were used to evaluate rat sensory and motor function. Somatosensory-evoked potentials of the tibial nerve of a hind paw of the rat were measured to evaluate the electrophysiological function of injured spinal cord. Western blot analysis was performed to measure p38-RhoA and ERK1/2-Bcl-2 pathways related protein levels in the injured spinal cord. Rat sensory and motor functions were similar between SCI and ES groups. Compared with the SCI group, in the ES group, the latencies of the somatosensory-evoked potential of the tibial nerve of rats were significantly shortened, the amplitudes were significantly increased, RhoA protein level was significantly decreased, protein gene product 9.5 expression, ERK1/2, p38, and Bcl-2 protein levels in the spinal cord were significantly increased. These data suggest that ES can promote the recovery of electrophysiological function of the injured spinal cord through regulating p38-RhoA and ERK1/2-Bcl-2 pathway-related protein levels in the injured spinal cord.

  17. Effect of Aspirin on Spinal Cord Injury: An Experimental Study

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    Hamed Reihani Kermani

    2016-05-01

    Full Text Available Aspirin is an anti-inflammatory drug, peroxyl radical scavenger, and antioxidant agent that inhibits phospholipases, nitric oxide synthetases, and cyclooxygenase enzymes. The existing literature contains no studies on the effects of various doses of aspirin on spinal cord injury (SCI. Therefore, we sought to investigate the putative effects of aspirin on experimental SCI. The weight-drop injury model was used to produce SCI in 100 albino Wistar rats. The animals were allocated to five groups: a control group, where the rats did not undergo any surgical or medical intervention except for anesthesia; a sham-treated group, where laminectomy was performed without SCI and no further therapy was administered; and three other groups, where the rats with SCI received low-dose aspirin [20 mg/kg], high-dose aspirin [80 mg/kg], and a vehicle, respectively. Half of the rats were sacrificed 24 hours later, and their spinal cords were excised for biochemical studies. The other rats were subjected to Basso, Beattie, and Bresnahan (BBB locomotor rating scale scoring once a week for 6 consecutive weeks. Aspirin decreased lipid peroxidation following SCI as the mean (± standard error catalase level was significantly higher in the high-dose aspirin group (46.10±12.01 than in the sham-treated group (16.07±2.42 and the vehicle-treated group (15.31±3.20 (P<0.05; P<0.05, respectively. Both of the groups treated with high-dose and low-dose aspirin demonstrated a higher mean BBB score than did the control group (P<0.001 and the sham-treated group (P<0.001. Our data provide evidence in support of the potential effects of aspirin in biochemical and neurobehavioral recovery after SCI.

  18. Effect of low-energy extracorporeal shock wave on vascular regeneration after spinal cord injury and the recovery of motor function.

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    Wang, Lei; Jiang, Yuquan; Jiang, Zheng; Han, Lizhang

    2016-01-01

    Latest studies show that low-energy extracorporeal shock wave therapy (ESWT) can upregulate levels of vascular endothelial growth factor (VEGF). VEGF can ease nervous tissue harm after spinal cord injury (SCI). This study aims to explore whether low-energy ESWT can promote expression of VEGF, protect nervous tissue after SCI, and improve motor function. Ninety adult female rats were divided into the following groups: Group A (simple laminectomy), Group B (laminectomy and low-energy ESWT), Group C (spinal cord injury), and Group D (spinal cord injury and low-energy ESWT). Impinger was used to cause thoracic spinal cord injury. Low-energy ESWT was applied as treatment after injury three times a week, for 3 weeks. After SCI, the Basso, Beattie, and Bresnahan (BBB) scale was used to evaluate motor function over a period of 42 days at different time points. Hematoxylin and eosin (HE) staining was used to evaluate nerve tissue injury. Neuronal nuclear antigen (NeuN) staining was also used to evaluate loss of neurons. Polymerase chain reaction was used to detect messenger RNA (mRNA) expression of VEGF and its receptor fms-like tyrosine kinase 1 (Flt-1). Immunostaining was used to evaluate VEGF protein expression level in myeloid tissue. BBB scores of Groups A and B showed no significant result related to dyskinesia. HE and NeuN staining indicated that only using low-energy ESWT could not cause damage of nervous tissue in Group B. Recovery of motor function at 7, 35, and 42 days after SCI in Group D was better than that in Group C (Pfunction. It can be regarded as one mode of clinical routine adjunctive therapy for spinal injury.

  19. Effect of electrical stimulation on neural regeneration via the p38-RhoA and ERK1/2-Bcl-2 pathways in spinal cord-injured rats

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    Joo, Min Cheol; Jang, Chul Hwan; Park, Jong Tae; Choi, Seung Won; Ro, Seungil; Kim, Min Seob; Lee, Moon Young

    2018-01-01

    Although electrical stimulation is therapeutically applied for neural regeneration in patients, it remains unclear how electrical stimulation exerts its effects at the molecular level on spinal cord injury (SCI). To identify the signaling pathway involved in electrical stimulation improving the function of injured spinal cord, 21 female Sprague-Dawley rats were randomly assigned to three groups: control (no surgical intervention, n = 6), SCI (SCI only, n = 5), and electrical simulation (ES; SCI induction followed by ES treatment, n = 10). A complete spinal cord transection was performed at the 10th thoracic level. Electrical stimulation of the injured spinal cord region was applied for 4 hours per day for 7 days. On days 2 and 7 post SCI, the Touch-Test Sensory Evaluators and the Basso-Beattie-Bresnahan locomotor scale were used to evaluate rat sensory and motor function. Somatosensory-evoked potentials of the tibial nerve of a hind paw of the rat were measured to evaluate the electrophysiological function of injured spinal cord. Western blot analysis was performed to measure p38-RhoA and ERK1/2-Bcl-2 pathways related protein levels in the injured spinal cord. Rat sensory and motor functions were similar between SCI and ES groups. Compared with the SCI group, in the ES group, the latencies of the somatosensory-evoked potential of the tibial nerve of rats were significantly shortened, the amplitudes were significantly increased, RhoA protein level was significantly decreased, protein gene product 9.5 expression, ERK1/2, p38, and Bcl-2 protein levels in the spinal cord were significantly increased. These data suggest that ES can promote the recovery of electrophysiological function of the injured spinal cord through regulating p38-RhoA and ERK1/2-Bcl-2 pathway-related protein levels in the injured spinal cord. PMID:29557386

  20. Role of spared pathways in locomotor recovery after body-weight-supported treadmill training in contused rats.

    Science.gov (United States)

    Singh, Anita; Balasubramanian, Sriram; Murray, Marion; Lemay, Michel; Houle, John

    2011-12-01

    Body-weight-supported treadmill training (BWSTT)-related locomotor recovery has been shown in spinalized animals. Only a few animal studies have demonstrated locomotor recovery after BWSTT in an incomplete spinal cord injury (SCI) model, such as contusion injury. The contribution of spared descending pathways after BWSTT to behavioral recovery is unclear. Our goal was to evaluate locomotor recovery in contused rats after BWSTT, and to study the role of spared pathways in spinal plasticity after BWSTT. Forty-eight rats received a contusion, a transection, or a contusion followed at 9 weeks by a second transection injury. Half of the animals in the three injury groups were given BWSTT for up to 8 weeks. Kinematics and the Basso-Beattie-Bresnahan (BBB) test assessed behavioral improvements. Changes in Hoffmann-reflex (H-reflex) rate depression property, soleus muscle mass, and sprouting of primary afferent fibers were also evaluated. BWSTT-contused animals showed accelerated locomotor recovery, improved H-reflex properties, reduced muscle atrophy, and decreased sprouting of small caliber afferent fibers. BBB scores were not improved by BWSTT. Untrained contused rats that received a transection exhibited a decrease in kinematic parameters immediately after the transection; in contrast, trained contused rats did not show an immediate decrease in kinematic parameters after transection. This suggests that BWSTT with spared descending pathways leads to neuroplasticity at the lumbar spinal level that is capable of maintaining locomotor activity. Discontinuing training after the transection in the trained contused rats abolished the improved kinematics within 2 weeks and led to a reversal of the improved H-reflex response, increased muscle atrophy, and an increase in primary afferent fiber sprouting. Thus continued training may be required for maintenance of the recovery. Transected animals had no effect of BWSTT, indicating that in the absence of spared pathways this

  1. Transplantation of Neural Precursor Cells Attenuates Chronic Immune Environment in Cervical Spinal Cord Injury

    Directory of Open Access Journals (Sweden)

    Lennart Riemann

    2018-06-01

    Full Text Available Inflammation after traumatic spinal cord injury (SCI is non-resolving and thus still present in chronic injury stages. It plays a key role in the pathophysiology of SCI and has been associated with further neurodegeneration and development of neuropathic pain. Neural precursor cells (NPCs have been shown to reduce the acute and sub-acute inflammatory response after SCI. In the present study, we examined effects of NPC transplantation on the immune environment in chronic stages of SCI. SCI was induced in rats by clip-compression of the cervical spinal cord at the level C6-C7. NPCs were transplanted 10 days post-injury. The functional outcome was assessed weekly for 8 weeks using the Basso, Beattie, and Bresnahan scale, the CatWalk system, and the grid walk test. Afterwards, the rats were sacrificed, and spinal cord sections were examined for M1/M2 macrophages, T lymphocytes, astrogliosis, and apoptosis using immunofluorescence staining. Rats treated with NPCs had compared to the control group significantly fewer pro-inflammatory M1 macrophages and reduced immunodensity for inducible nitric oxide synthase (iNOS, their marker enzyme. Anti-inflammatory M2 macrophages were rarely present 8 weeks after the SCI. In this model, the sub-acute transplantation of NPCs did not support survival and proliferation of M2 macrophages. Post-traumatic apoptosis, however, was significantly reduced in the NPC group, which might be explained by the altered microenvironment following NPC transplantation. Corresponding to these findings, reactive astrogliosis was significantly reduced in NPC-transplanted animals. Furthermore, we could observe a trend toward smaller cavity sizes and functional improvement following NPC transplantation. Our data suggest that transplantation of NPCs following SCI might attenuate inflammation even in chronic injury stages. This might prevent further neurodegeneration and could also set a stage for improved neuroregeneration after SCI.

  2. Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis.

    Science.gov (United States)

    Watzlawick, Ralf; Sena, Emily S; Dirnagl, Ulrich; Brommer, Benedikt; Kopp, Marcel A; Macleod, Malcolm R; Howells, David W; Schwab, Jan M

    2014-01-01

    Blockade of small GTPase-RhoA signaling pathway is considered a candidate translational strategy to improve functional outcome after spinal cord injury (SCI) in humans. Pooling preclinical evidence by orthodox meta-analysis is confounded by missing data (publication bias). To conduct a systematic review and meta-analysis of RhoA/Rho-associated coiled-coil containing protein kinase (ROCK) blocking approaches to (1) analyze the impact of bias that may lead to inflated effect sizes and (2) determine the normalized effect size of functional locomotor recovery after experimental thoracic SCI. We conducted a systematic search of PubMed, EMBASE, and Web of Science and hand searched related references. Studies were selected if they reported the effect of RhoA/ROCK inhibitors (C3-exoenzmye, fasudil, Y-27632, ibuprofen, siRhoA, and p21) in experimental spinal cord hemisection, contusion, or transection on locomotor recovery measured by the Basso, Beattie, and Bresnahan score or the Basso Mouse Scale for Locomotion. Two investigators independently assessed the identified studies. Details of individual study characteristics from each publication were extracted and effect sizes pooled using a random effects model. We assessed risk for bias using a 9-point-item quality checklist and calculated publication bias with Egger regression and the trim and fill method. A stratified meta-analysis was used to assess the impact of study characteristics on locomotor recovery. Thirty studies (725 animals) were identified. RhoA/ROCK inhibition was found to improve locomotor outcome by 21% (95% CI, 16.0-26.6). Assessment of publication bias by the trim and fill method suggested that 30% of experiments remain unpublished. Inclusion of these theoretical missing studies suggested a 27% overestimation of efficacy, reducing the overall efficacy to a 15% improvement in locomotor recovery. Low study quality was associated with larger estimates of neurobehavioral outcome. Taking into account

  3. Sistemi riconfigurabili a basso consumo per applicazioni di monitoraggio distribuito

    OpenAIRE

    Magno, Michele

    2010-01-01

    The term Ambient Intelligence (AmI) refers to a vision on the future of the information society where smart, electronic environment are sensitive and responsive to the presence of people and their activities (Context awareness). In an ambient intelligence world, devices work in concert to support people in carrying out their everyday life activities, tasks and rituals in an easy, natural way using information and intelligence that is hidden in the network connecting these devices. This pro...

  4. Parnaparin: confronto con le altre eparine a basso peso molecolare

    Directory of Open Access Journals (Sweden)

    Lorenzo Pradelli

    2004-03-01

    Full Text Available Sodium parnaparin is a low molecular weight heparin (LMWH. The introduction of this drug class has represented a medical advancement in the prevention and therapy of thromboembolic pathologies, as they maintain the same efficacy of unfractionated heparin, but with simplified dosing regimens and reduced side effects. Parnaparin has demonstrated its thromboprophylactic efficacy on both high- and moderate risk surgical patients, besides resulting effective in treating established deep vein thromboses and thrombosis-associated phlebopathies. Alongside these clinical advantages, parnaparin and other LMWHs allow outpatient or home-based therapy of a large number of subjects that should otherwise be treated in hospital, with important savings of health resources and enhanced quality of life for the patients. In Italy, parnaparin drug acquisition cost is the lowest among all LMWHs for the majority of their applications, permitting marginal savings in health costs at the same efficacy level. In summary, the use of parnaparin in thrombotic pathologies has very good efficacy and safety profiles, and has positive clinical and economical outcomes for patients, health system and society as a whole.

  5. Parnaparin: confronto con le altre eparine a basso peso molecolare

    Directory of Open Access Journals (Sweden)

    Lorenzo Pradelli

    2005-09-01

    Full Text Available Sodium parnaparin is a low molecular weight heparin (LMWH. The introduction of this drug class has represented a medical advancement in the prevention and therapy of thromboembolic pathologies, as they maintain the same efficacy of unfractionated heparin, but with simplified dosing regimens and reduced side effects. Parnaparin has demonstrated its thromboprophylactic efficacy on both high- and moderate risk surgical patients, besides resulting effective in treating established deep vein thromboses and thrombosis-associated phlebopathies. Alongside these clinical advantages, parnaparin and other LMWHs allow outpatient or home-based therapy of a large number of subjects that should otherwise be treated in hospital, with important savings of health resources and enhanced quality of life for the patients. In Italy, parnaparin drug acquisition cost is among the lowest in its class for many applications, permitting marginal savings in health costs at the same efficacy level. In summary, the use of parnaparin in thrombotic pathologies has very good efficacy and safety profiles, and has positive clinical and economical outcomes for patients, health system and society as a whole.

  6. Approccio dal basso, servizi alla persona e memorie interculturali

    Directory of Open Access Journals (Sweden)

    Orazio Maria Valastro

    2003-06-01

    Full Text Available Valorizzare le memorie dei migranti risponde ad una precisa esigenza di riconoscimento, nella storia collettiva e nello spazio politico nazionale, della memoria interculturale di intere collettività ... Queste condizioni implicano l'esigenza del riconoscimento della memoria dei migranti traducendosi in uno stimolo per lo sviluppo di nuove politiche sociali e culturali e di nuovi interventi focalizzati su questo stesso riconoscimento che interessa direttamente anche gli operatori sociali e culturali delle amministrazioni pubbliche e del terzo settore.

  7. Water-vapor movement through unsaturated alluvium in Amargosa Desert near Beatty, Nevada - Current understanding and continuing studies: A section in Joint US Geological Survey, US Nuclear Regulatory Commission workshop on research related to low-level radioactive waste disposal, May 4-6, 1993, National Center, Reston, Virginia; Proceedings (WRI 95-4015)

    Science.gov (United States)

    Prudic, David E.; Stevens, Peter R.; Nicholson, Thomas J.

    1996-01-01

    Disposal of low-level radioactive wastes has been a concern since the 1950's. These wastes commonly are buried in shallow trenches (Fischer, 1986, p. 2). Water infiltrating into the trenches is considered the principal process by which contaminants are transported away from the buried wastes, although gaseous transport in some areas may be important. Arid regions in the western United States have been suggested as places that could provide safe containment of the wastes, because little or no water would infiltrate into the trenches (Richardson, 1962), and because thick unsaturated zones would slow contaminant movement. Although burial in arid regions may greatly reduce the amount of water coming in contact with the waste and consequently may provide longterm containment, insufficient data are available on the effectiveness of burial in such regions. Of particular interest is the potential for contaminant movement, either as liquid or vapor, through unsaturated sediments to land surface or to underlying ground water.Since 1962, low-level radioactive wastes have been buried at a disposal facility in the Amargosa Desert, about 17 km south of Beatty, Nevada (fig. 50). This facility is in one of the most arid regions of the United States. Annual precipitation at the disposal facility averaged 82 mm for 1985-92; the minimum was 14 mm, recorded for 1989 (Wood and Andraski, 1992, p. 12).Investigations to determine the hydrogeology, water movement, and potential for contaminant movement at the facility began in 1976. Results from an initial study indicated that a potential exists for deep percolation of infiltrated water at the burial site (Nichols, 1987), assuming that the only water loss is by evaporation because the trenches are kept clear of vegetation. Results from a subsequent study of water movement beneath an undisturbed, vegetated site indicate that percolation of infiltrated water may be limited to the uppermost 9 m of sediments, on the basis of water potentials

  8. Overexpression of HIPK2 attenuates spinal cord injury in rats by modulating apoptosis, oxidative stress, and inflammation.

    Science.gov (United States)

    Li, Renbo; Shang, Jingbo; Zhou, Wei; Jiang, Li; Xie, Donghui; Tu, Guanjun

    2018-04-09

    HIPK2 is considered to be a tumor suppressor. It also has been implicated in several functions such as apoptosis and inflammation that are linked to spinal cord injury (SCI). However, whether HIPK2 ameliorates the neurological pain of SCI remains unclear. Here, we investigated the effects of HIPK2 on neurological function, oxidative stress, levels of inflammatory cytokines and expression of Bcl-2/Bax in an SCI model. Firstly, we evaluated the therapeutic effects of HIPK2 on neurological pain in the SCI rat using the Basso, Beattie and Bresnahan scores and H & E staining. Overexpression of HIPK2 significantly elevated the levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF), and reduced the mRNA expression of Nogo-A and RhoA in SCI rats. Furthermore, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assays showed that overexpression of HIPK2 significantly reduced the number of apoptotic cells. Overexpression of HIPK2 also decreased expression of Bax and Caspase-3 and elevated expression of Bcl-2 in the SCI model, indicating that HIPK2 exhibited its protective activity by inhibiting SCI-induced apoptosis. Then, we measured the serum concentrations of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX). We also determined the mRNA and protein levels of nuclear factor-κB p65 unit, tumor necrosis factor-α (TNF-α), and interleukin (IL)-1β. HIPK2 overexpression reduced oxidative stress and the levels of inflammatory cytokines compared with SCI control animals. Additionally, acetylation of HIPK2 was reduced in SCI rats. Overexpression of HIPK2 could enhance autophagy by elevating the expression of Beclin-1 and LC3-II while autophagy is regarded as a beneficial regulator to improve spinal cord injury. Together, overexpression of HIPK2 improved contusive SCI induced pain by modulating oxidative stress, Bcl‑2 and Bax signaling, and

  9. Neurorestoratology evidence in an animal model with cervical spondylotic myelopathy

    Directory of Open Access Journals (Sweden)

    Li X

    2017-01-01

    Full Text Available Xiang Li,1,2 Guangsheng Li,1,3 Keith Dip-Kei Luk,1 Yong Hu1–3 1Department of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong, 2Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 3Spinal Division, Department of Orthopaedics, Affiliated Hospital of Guangdong Medical University, Guangdong, People’s Republic of China Background: Cervical spondylotic myelopathy (CSM is a chronic compression injury of the spinal cord, with potentially reversible conditions after surgical decompression, and a unique model of incomplete spinal cord injury. Several animal studies showed pathological changes of demyelination, axon loss and neuron apoptosis in rats with chronic spinal cord compression. However, there is a limited understanding of the neurological change in the spinal cord after surgical decompression. The aim of this study was to validate the neurorestoratology of myelopathic lesions in the spinal cord in a rat model. Materials and methods: A total of 16 adult Sprague-Dawley rats were divided into four groups: sham control (group 1; CSM model with 4-week chronic compression (group 2, 2 weeks (group 3 and 4 weeks (group 4 after surgical decompression of CSM model. The compression and decompression were verified by magnetic resonance imaging (MRI test. Neurological function was evaluated by Basso, Beattie, and Bresnahan (BBB locomotor rating scale, ladder rung walking test and somatosensory-evoked potentials (SEPs. Neuropathological change was evaluated by histological examinations. Results: MRI confirmed the compression of the cervical spinal cord as well as the reshaping of cord morphology after decompression. After decompression, significant changes of neurological function were observed in BBB scores (p < 0.01, F = 10.52, ladder rung walking test (p < 0.05, F = 14.21 and latencies (p < 0.05, F = 5.76 and amplitudes (p < 0.05, F = 3.8 of

  10. Low-energy extracorporeal shock wave therapy promotes vascular endothelial growth factor expression and improves locomotor recovery after spinal cord injury.

    Science.gov (United States)

    Yamaya, Seiji; Ozawa, Hiroshi; Kanno, Haruo; Kishimoto, Koshi N; Sekiguchi, Akira; Tateda, Satoshi; Yahata, Kenichiro; Ito, Kenta; Shimokawa, Hiroaki; Itoi, Eiji

    2014-12-01

    Extracorporeal shock wave therapy (ESWT) is widely used for the clinical treatment of various human diseases. Recent studies have demonstrated that low-energy ESWT upregulates the expression of vascular endothelial growth factor (VEGF) and promotes angiogenesis and functional recovery in myocardial infarction and peripheral artery disease. Many previous reports suggested that VEGF produces a neuroprotective effect to reduce secondary neural tissue damage after spinal cord injury (SCI). The purpose of the present study was to investigate whether low-energy ESWT promotes VEGF expression and neuroprotection and improves locomotor recovery after SCI. Sixty adult female Sprague-Dawley rats were randomly divided into 4 groups: sham group (laminectomy only), sham-SW group (low-energy ESWT applied after laminectomy), SCI group (SCI only), and SCI-SW group (low-energy ESWT applied after SCI). Thoracic spinal cord contusion injury was inflicted using an impactor. Low-energy ESWT was applied to the injured spinal cord 3 times a week for 3 weeks. Locomotor function was evaluated using the Basso, Beattie, and Bresnahan (BBB) Scale (open field locomotor score) at different time points over 42 days after SCI. Hematoxylin and eosin staining was performed to assess neural tissue damage in the spinal cord. Neuronal loss was investigated by immunostaining for NeuN. The mRNA expressions of VEGF and its receptor, Flt-1, in the spinal cord were assessed using real-time polymerase chain reaction. Immunostaining for VEGF was performed to evaluate VEGF protein expression in the spinal cord. In both the sham and sham-SW groups, no animals showed locomotor impairment on BBB scoring. Histological analysis of H & E and NeuN stainings in the sham-SW group confirmed that no neural tissue damage was induced by the low-energy ESWT. Importantly, animals in the SCI-SW group demonstrated significantly better locomotor improvement than those in the SCI group at 7, 35, and 42 days after injury (p

  11. [RECONSTRUCTION OF LOWER EXTREMITY FUNCTION OF COMPLETE SPINAL CORD INJURY RATS BY FIRST NEURON CONNECTION].

    Science.gov (United States)

    Wang, Fangyong; Yuan, Yuan; Li, Jianjun

    2015-12-01

    To investigate the effects of the first neuron connection for the reconstruction of lower extremity function of complete spinal cord injury rats. Forty adult female Sprague Dawley rats of 300-350 g in weight were selected to prepare the models of L₁ transverse spinal cord injury. After 2 weeks of establishing model, the rats were randomly divided into control group (n = 20) and experimental group (n = 20). In the experimental group, the right hind limb function was reconstructed directly by the first neuron; in the control group, the other treatments were the same to the experimental group except that the distal tibial nerve and the proximal femoral nerve were not sutured. The recovery of motor function of lower extremity was observed by the Basso-Beattie-Bresnahan (BBB) scoring system on bilateral hind limbs at 7, 30, 50, and 70 days after operation. The changes of the spinal cord were observed by HE staining, neurofilament 200 immunohistochemistry staining, and the technique of horseradish peroxidase (HRP) tracing. After establishing models, 6 rats died. The right hind limb had no obvious recovery of the motor function, with the BBB score of 0 in 2 groups; the left hind limb motor function was recovered in different degrees, and there was no significant difference in BBB score between 2 groups (P > 0.05). In the experimental group, HE staining showed that the spinal cord was reconstructed with the sciatic nerve, which was embedded in the spinal cord, and the sciatic nerve membrane was clearly identified, and there was no obvious atrophy in the connecting part of the spinal cord. In the experimental group, the expression of nerve fiber was stained with immunohistochemistry, and the axons of the spinal cord were positively by stained and the peripheral nerve was connected with the spinal cord. HRP labelled synapses were detected by HRP retrograde tracing in the experimental group, while there was no HRP labelled synapse in the control group. Direct reconstruction

  12. Bone Marrow Mesenchymal Stem-Cell Transplantation Promotes Functional Improvement Associated with CNTF-STAT3 Activation after Hemi-Sectioned Spinal Cord Injury in Tree Shrews

    Directory of Open Access Journals (Sweden)

    Liu-Lin Xiong

    2017-06-01

    Full Text Available Hemi-sectioned spinal cord injury (hSCI can lead to spastic paralysis on the injured side, as well as flaccid paralysis on the contralateral side, which can negatively affect a patient’s daily life. Stem-cell therapy may offer an effective treatment option for individuals with hSCI. To examine the role of bone marrow mesenchymal stem cells (BMSCs transplantation on hSCI and explore related mechanisms in the tree shrews, here, we created a model of hSCI by inducing injury at the tenth thoracic vertebra (T10. Hoechst 33342-labeled BMSCs derived from adult tree shrews were isolated, cultured, and implanted into the spinal cord around the injury site at 9 days after injury. The isolated BMSCs were able to survive, proliferate and release a variety of neurotrophic factors (NTFs both in vitro and in vivo. At 28 days after injury, compared with the sham group, the hSCI group displayed scar formation and dramatic elevations in the mean interleukin 1 beta (IL-1β density and cell apoptosis level, whereas the expression of signal transducer and activator of transcription 3 (STAT3 and ciliary neurotrophic factor (CNTF mRNA was reduced. Following BMSC transplantation, motoneurons extent of shrinkage were reduced and the animals’ Basso, Beattie, and Bresnahan (BBB locomotion scale scores were significantly higher at 21 and 28 days after injury when compared with the injured group. Moreover, the hSCI-induced elevations in scar formation, IL-1β, and cell apoptosis were reduced by BMSC transplantation to levels that were close to those of the sham group. Corresponding elevations in the expression of STAT3 and CNTF mRNA were observed in the hSCI + BMSCs group, and the levels were not significantly different from those observed in the sham group. Together, our results support that grafted BMSCs can significantly improve locomotor function in tree shrews subjected to hSCI and that this improvement is associated with the upregulation of CNTF and STAT3

  13. Does timing of transplantation of neural stem cells following spinal cord injury affect outcomes in an animal model?

    Science.gov (United States)

    Cheng, Ivan; Park, Don Y; Mayle, Robert E; Githens, Michael; Smith, Robert L; Park, Howard Y; Hu, Serena S; Alamin, Todd F; Wood, Kirkham B; Kharazi, Alexander I

    2017-12-01

    We previously reported that functional recovery of rats with spinal cord contusions can occur after acute transplantation of neural stem cells distal to the site of injury. To investigate the effects of timing of administration of human neural stem cell (hNSC) distal to the site of spinal cord injury on functional outcomes in an animal model. Thirty-six adult female Long-Evans hooded rats were randomized into three experimental and three control groups with six animals in each group. The T10 level was exposed via posterior laminectomy, and a moderate spinal cord contusion was induced by the Multicenter Animal Spinal Cord Injury Study Impactor (MASCIS, W.M. Keck Center for Collaborative Neuroscience, Piscataway, NJ, USA). The animals received either an intrathecal injection of hNSCs or control media through a separate distal laminotomy immediately, one week or four weeks after the induced spinal cord injury. Observers were blinded to the interventions. Functional assessment was measured immediately after injury and weekly using the Basso, Beattie, Bresnahan (BBB) locomotor rating score. A statistically significant functional improvement was seen in all three time groups when compared to their controls (acute, mean 9.2 vs. 4.5, P=0.016; subacute, mean 11.1 vs. 6.8, P=0.042; chronic, mean 11.3 vs. 5.8, P=0.035). Although there was no significant difference in the final BBB scores comparing the groups that received hNSCs, the group which achieved the greatest improvement from the time of cell injection was the subacute group (+10.3) and was significantly greater than the chronic group (+5.1, P=0.02). The distal intrathecal transplantation of hNSCs into the contused spinal cord of a rat led to significant functional recovery of the spinal cord when injected in the acute, subacute and chronic phases of spinal cord injury (SCI), although the greatest gains appeared to be in the subacute timing group.

  14. A rat model of chronic syringomyelia induced by epidural compression of the lumbar spinal cord.

    Science.gov (United States)

    Lee, Ji Yeoun; Kim, Shin Won; Kim, Saet Pyoul; Kim, Hyeonjin; Cheon, Jung-Eun; Kim, Seung-Ki; Paek, Sun Ha; Pang, Dachling; Wang, Kyu-Chang

    2017-10-01

    OBJECTIVE There has been no established animal model of syringomyelia associated with lumbosacral spinal lipoma. The research on the pathophysiology of syringomyelia has been focused on Chiari malformation, trauma, and inflammation. To understand the pathophysiology of syringomyelia associated with occult spinal dysraphism, a novel animal model of syringomyelia induced by chronic mechanical compression of the lumbar spinal cord was created. METHODS The model was made by epidural injection of highly concentrated paste-like kaolin solution through windows created by partial laminectomy of L-1 and L-5 vertebrae. Behavioral outcome in terms of motor (Basso-Beattie-Bresnahan score) and urinary function was assessed serially for 12 weeks. Magnetic resonance images were obtained in some animals to confirm the formation of a syrinx and to monitor changes in its size. Immunohistochemical studies, including analysis for glial fibrillary acidic protein, NeuN, CC1, ED-1, and caspase-3, were done. RESULTS By 12 weeks after the epidural compression procedure, syringomyelia formation was confirmed in 85% of the rats (34 of 40) on histology and/or MRI. The syrinx cavities were found rostral to the epidural compression. Motor deficit of varying degrees was seen immediately after the procedure in 28% of the rats (11 of 40). In 13 rats (33%), lower urinary tract dysfunction was seen. Motor deficit improved by 5 weeks after the procedure, whereas urinary dysfunction mostly improved by 2 weeks. Five rats (13%, 5 of 40) died 1 month postoperatively or later, and 3 of the 5 had developed urinary tract infection. At 12 weeks after the operation, IHC showed no inflammatory process, demyelination, or accelerated apoptosis in the spinal cords surrounding the syrinx cavities, similar to sham-operated animals. CONCLUSIONS A novel experimental model for syringomyelia by epidural compression of the lumbar spinal cord has been created. The authors hope that it will serve as an important research

  15. Acute dehydrating gastro-enteritis in undernourished infants | Beatty ...

    African Journals Online (AJOL)

    The use of half-strength Oarrow's solution in 2;5% dextrose water, with supplementary intravenous sodium bicarbonate and oral potassium, rapidly corrected the electrolyte and acid-base disturbances. No significant difference resulted when this regimen was modified by variations in the rate, volume or type of intravenous ...

  16. Pieris e Begliano: villaggi medievali del basso Isonzo dall‘incerta identità

    Directory of Open Access Journals (Sweden)

    Maurizio Puntin

    2015-12-01

    Full Text Available L’autore ha studiato a fondo, a cominciare dagli anni ’90, la toponomastica e l’antica antroponimia del Territorio di Monfalcone. Dopo la pubblicazione della II edizione dell’opera (P 2010 le ricerche sono continuate e hanno sempre confermato quei primi risultati. In pratica questo angolo sud-orientale del Friuli rientrò almeno fino a tutto il sec. XV nella Slavia submersa, con una maggioranza di abitanti slavofoni ed una minoranza parlante un dialetto friulano che si situava morfologicamente fra quello centrale e le antiche e scomparse parlate friulaneggianti di Trieste e Muggia. Nell’articolo si ripresentano brevemente molti nomi di persone e di luoghi di Pieris e Begliano (oggi Comune di S. Canzian d’Isonzo, con alcuni nuovi dati emersi ultimamente: per esempio sull’attuale località Isola Morosini (nel sec. XV Otoch che apparteneva in età medievale all’Abbazia benedettina di Moggio. Viene rivista anche l’etimologia del nome della località di Begliano, lasciata in sospeso nei lavori precedenti fra l’opzione predialistica romana (*Bellius e quella paleoslava (*Beljan o *Beljani; assegnando questo toponimo allo strato linguistico slavo. Bisogna distinguere però questo strato sloveno medievale da uno successivo, rappresentato essenzialmente da nomi e soprannomi di persone immigrate nel Monfalconese fra la fine del sec. XV e il sec. XVII. Gente di origine balcanica (sclabonus sive bisiacus che fuggiva dalle invasioni turche ed entrava in un angolo di Friuli soggetto a Venezia. I tre villaggi erano vicini all’antico traghetto (zopum di Pieris sul fiume Isonzo e la parte finale dell’articolo è dedicata alla discussione sull’etimo del termine friulano çòp/zòpul ‘piroga’ (slov. dial. čupa, su cui era intervenuto uno scrittore di Trieste proponendo un’origine slovena. L’autore dell’articolo mostra invece come non si possa facilmente disgiungere il termine çop/zop da tutta una trafila di voci, ben attestate nell’area romanza del nord-est italiano (compresa la lingua dalmatica oggi estinta. Voci che sembrano tutte gravitare attorno al semantema “ceppo, legno scavato” e che potrebbero in ultima analisi essere di lontana origine prelatina.

  17. Guadagni in conto capitale, fondi pensionistici e il basso saggio di risparmio negli Stati Uniti

    Directory of Open Access Journals (Sweden)

    J. STEINDL

    2013-10-01

    Full Text Available The United States has always been regarded as a consumer-oriented society. Statistics compiled for the 1980s demonstrate that the United States has a very low savings ratio. Two major factors are identified as causing this, the federal and state tax treatment of loan interest and the high volume of consumer credit. There are dangers associated with this short-term perspective of instant consumerism, and institutions dealing in long-term financial management (pension/insurance companies have particular problems in this respect.  JEL Codes: E21 

  18. Effects of Early Acute Care on Autonomic Outcomes in SCI: Bedside to Bench and Back

    Science.gov (United States)

    2015-10-01

    William Whetstone MD from Emergency Medicine and Geoffrey Manley MD, PhD who are already on the project. This team has worked together on the...Cessante LM, Cheung CR, Cullen MA, McDonald EC, Holland MC. Routine TBI screening following combat deployments. NeuroRehabilitation. 2010; 26(3):183...1,3,4 William Whetstone,2 Rajiv Saigal,3,4 Adam Ferguson,3,4 Jason Talbott,5 Jacqueline Bresnahan,3,4 Sanjay Dhall,3,4 Jonathan Pan,6 Michael Beattie

  19. Low-energy extracorporeal shock wave therapy for promotion of vascular endothelial growth factor expression and angiogenesis and improvement of locomotor and sensory functions after spinal cord injury.

    Science.gov (United States)

    Yahata, Kenichiro; Kanno, Haruo; Ozawa, Hiroshi; Yamaya, Seiji; Tateda, Satoshi; Ito, Kenta; Shimokawa, Hiroaki; Itoi, Eiji

    2016-12-01

    OBJECTIVE Extracorporeal shock wave therapy (ESWT) is widely used to treat various human diseases. Low-energy ESWT increases expression of vascular endothelial growth factor (VEGF) in cultured endothelial cells. The VEGF stimulates not only endothelial cells to promote angiogenesis but also neural cells to induce neuroprotective effects. A previous study by these authors demonstrated that low-energy ESWT promoted expression of VEGF in damaged neural tissue and improved locomotor function after spinal cord injury (SCI). However, the neuroprotective mechanisms in the injured spinal cord produced by low-energy ESWT are still unknown. In the present study, the authors investigated the cell specificity of VEGF expression in injured spinal cords and angiogenesis induced by low-energy ESWT. They also examined the neuroprotective effects of low-energy ESWT on cell death, axonal damage, and white matter sparing as well as the therapeutic effect for improvement of sensory function following SCI. METHODS Adult female Sprague-Dawley rats were divided into the SCI group (SCI only) and SCI-SW group (low-energy ESWT applied after SCI). Thoracic SCI was produced using a New York University Impactor. Low-energy ESWT was applied to the injured spinal cord 3 times a week for 3 weeks after SCI. Locomotor function was evaluated using the Basso, Beattie, and Bresnahan open-field locomotor score for 42 days after SCI. Mechanical and thermal allodynia in the hindpaw were evaluated for 42 days. Double staining for VEGF and various cell-type markers (NeuN, GFAP, and Olig2) was performed at Day 7; TUNEL staining was also performed at Day 7. Immunohistochemical staining for CD31, α-SMA, and 5-HT was performed on spinal cord sections taken 42 days after SCI. Luxol fast blue staining was performed at Day 42. RESULTS Low-energy ESWT significantly improved not only locomotion but also mechanical and thermal allodynia following SCI. In the double staining, expression of VEGF was observed in Neu

  20. Transplantation of oligodendrocyte precursors and sonic hedgehog results in improved function and white matter sparing in the spinal cords of adult rats after contusion.

    Science.gov (United States)

    Bambakidis, Nicholas C; Miller, Robert H

    2004-01-01

    A substantial cause of neurological disability in spinal cord injury is oligodendrocyte death leading to demyelination and axonal degeneration. Rescuing oligodendrocytes and preserving myelin is expected to result in significant improvement in functional outcome after spinal cord injury. Although previous investigators have used cellular transplantation of xenografted pluripotent embryonic stem cells and observed improved functional outcome, these transplants have required steroid administration and only a minority of these cells develop into oligodendrocytes. The objective of the present study was to determine whether allografts of oligodendrocyte precursors transplanted into an area of incomplete spinal cord contusion would improve behavioral and electrophysiological measures of spinal cord function. Additional treatment incorporated the use of the glycoprotein molecule Sonic hedgehog (Shh), which has been shown to play a critical role in oligodendroglial development and induce proliferation of endogenous neural precursors after spinal cord injury. Laboratory study. Moderate spinal cord contusion injury was produced in 39 adult rats at T9-T10. Ten animals died during the course of the study. Nine rats served as contusion controls (Group 1). Six rats were treated with oligodendrocyte precursor transplantation 5 days after injury (Group 2). The transplanted cells were isolated from newborn rat pups using immunopanning techniques. Another eight rats received an injection of recombinant Shh along with the oligodendrocyte precursors (Group 3), while six more rats were treated with Shh alone (Group 4). Eight additional rats received only T9 laminectomies to serve as noninjured controls (Group 0). Animals were followed for 28 days. After an initial complete hindlimb paralysis, rats of all groups receiving a contusive injury recovered substantial function within 1 week. By 28 days, rats in Groups 2 and 3 scored 4.7 and 5.8 points better on the Basso, Beattie, Bresnahan

  1. Therapeutic effects of NogoA vaccine and olfactory ensheathing glial cell implantation on acute spinal cord injury

    Directory of Open Access Journals (Sweden)

    Zhang Z

    2013-10-01

    group, and a combined treatment group. Animal behavior, histopathology, and axonal regeneration were compared between the four treatment groups. Results: The antibody against the polypeptide was detected in rat serum by enzyme-linked immunosorbent assay. Experimental autoimmune encephalomyelitis was not found in the immunized rats. Three months after injury, Basso, Beattie, Bresnahan scores and nerve fiber counts in biotinylated dextran amine nerve tracing studies were significantly better in the combined treatment group than in the other groups. Conclusion: The polypeptide NogoA vaccine can stimulate the humoral immune system to produce antibodies against the NogoA polypeptide. The binding reaction between the antibody and antigen was shown in ex vivo experiments. No evidence was found to suggest a relationship between NogoA vaccination and increased risk of experimental autoimmune encephalomyelitis. The combined strategy of olfactory ensheathing glial cell implantation and NogoA vaccination may promote regeneration of axons and functional recovery in the spinal cord contusion injury model. This study may provide a new strategy for combining modalities to enhance axonal regeneration and a better balance of the CNS microenvironment after SCI. Keywords: spinal cord injury, immunotherapy, cell transplantation, olfactory ensheathing glial cells, NogoA, vaccine

  2. Editoriale - Per il verso giusto: destra/sinistra, alto/basso, davanti/dietro nell'immagine

    Directory of Open Access Journals (Sweden)

    Alice Barale

    2012-10-01

    Full Text Available Things are not the same when, even remaining the same, they are placed on the right or on the left, above or below, in front or behind. In the concrete space of our daily experience, in the space of myths and religions, we are not confronted with a neutral, homogeneous, infinite and isotropic spatiality, indifferent to directions. On the contrary, the possibility of a meaningful movement in space, rooted in my own body and in its praxis (as Kant shows in his pre-critical and critical essays devoted to the space regions and to orientation, is assigned to the three main axes (above/below, right/left, front/behind and their correspondent differences. The same applies for the space of images and pictures. The present issue of “Aisthesis” aims at exploring how the articulations above/below, right/left, front/behind produce a difference – syntactic, semantic, pragmatic and symbolic – in the iconic domain, and at investigating what theoretical models can be employed in order to understand such difference.

  3. Isotopic composition of water in a deep unsaturated zone beside a radioactive-waste disposal area near Beatty, Nevada

    Science.gov (United States)

    Stonestrom, David A.; Prudic, David E.; Striegl, Robert G.; Morganwalp, David W.; Buxton, Herbert T.

    1999-01-01

    The isotopic composition of water in deep unsaturated zones is of interest because it provides information relevant to hydrologic processes and contaminant migration. Profiles of oxygen-18 (18O), deuterium (D), and tritium (3H) from a 110-meter deep unsaturated zone, together with data on the isotopic composition of ground water and modern-day precipitation, are interpreted in the context of water-content, water-potential, and pore-gas profiles. At depths greater than about three meters, water vapor and liquid water are in approximate equilibrium with respect to D and 18O. The vapor-phase concentrations of D and 18O have remained stable through repeated samplings. Vapor-phase 3H concentrations have generally increased with time, requiring synchronous sampling of liquid and vapor to assess equilibrium. Below 30 meters, concentrations of D and 18O in pore water become approximately equal to the composition of ground water, which is isotopically lighter than modern precipitation and has a carbon-14 (14C) concentration of about 26 percent modern carbon. These data indicate that net gradients driving fluxes of water, gas, and heat are directed upwards for undisturbed conditions at the Amargosa Desert Research Site (ADRS). Superimposed on the upward-directed flow field, tritium is migrating away from waste in response to gradients in tritium concentrations.

  4. Assessment of microbial processes on radionuclide mobility in shallow land burial. [West Valley, NY; Beatty, Nevada; Maxey Flats, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    Colombo, P.; Tate, R.L. III; Weiss, A.J.

    1982-07-01

    The impact of microbial metabolism of the organic substituents of low level radioactive wastes on radionuclide mobility in disposal sites, the nature of the microbial transformations involved in this metabolism and the effect of the prevailing environmental parameters on the quantities and types of metabolic intermediates accumulated were examined. Since both aerobic and anaerobic periods can occur during trench ecosystem development, oxidation capacities of the microbial community in the presence and absence of oxygen were analyzed. Results of gas studies performed at three commercial low level radioactive waste disposal sites were reviewed. Several deficiencies in available data were determined. Further research needs are suggested. This assessment has demonstrated that the biochemical capabilities expressed within the low level radioactive waste disposal site are common to a wide variety of soil bacteria. Hence, assuming trenches would not be placed in sites with such extreme abiotic conditions that all microbial activity is precluded, the microbial populations needed for colonization and decomposition of the organic waste substances are readily provided from the waste itself and from the soil of existing and any proposed disposal sites. Indeed, considering the ubiquity of occurrence of the microorganisms responsible for waste decomposition and the chemical nature of the organic waste material, long-term prevention of biodecomposition is difficult, if not impossible.

  5. Water pollution monitoring in Tirrenian Sea 1991--1993; Monitoraggio ambientale nel bacino del basso Tirreno nel triennio 1991-1993

    Energy Technology Data Exchange (ETDEWEB)

    Scipioni, A.; Napoli, M. [Padova Univ. (Italy), Ist. di Chimica Industriale; Cavolo, F. [Padova Univ. (Italy), Dip.di Biologia

    1996-07-01

    A marine environmental research programme is in course of carrying out for some years in a definite coastal zone of the southern Tirrenian Sea in order to point out possible significant pollutions, identify their origin and study the appropriate preventive and protective measures. In the first stage of the programme the analysis of the actual water quality was done, by evaluation of several indicators (temperature, conductivity, pH, turbidity and suspended sediments, dissolved oxygen, chlorophyll a, nutrients concentration, bacteriological parameters) at three different distances from the shore: 50 m, 500 m and 1 mile. The analysis of the collected values shows that the actual water quality is on the whole quite satisfactory, except for some restricted areas in which a bacteriological pollution, due to high concentrations of coliforms and Streptococcus faecalis, has been pointed out.

  6. Comment on "An explanation for the charge on water's surface" by A. Gray-Weale and J. K. Beattie, Phys. Chem. Chem. Phys., 2009, 11, 10994

    Czech Academy of Sciences Publication Activity Database

    Vácha, Robert; Horinek, D.; Buchner, R.; Winter, B.; Jungwirth, Pavel

    2010-01-01

    Roč. 12, č. 42 (2010), s. 14362-14363 ISSN 1463-9076 Institutional research plan: CEZ:AV0Z40550506 Keywords : surface charge * water * dielectric decrement Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 3.454, year: 2010

  7. Final Report for the MANNRRSS II Program Management of Nevada's Natural Resources with Remote Sensing Systems, Beatty, NV

    Energy Technology Data Exchange (ETDEWEB)

    Lester Miller; Brian Horowitz; Chris Kratt; Tim Minor; Stephen F. Zitzer; James. V. Taranik; Zan L. Aslett; Todd O. Morken

    2009-06-04

    This document provides the Final Report on the Management of Nevada’s Natural Resources with Remote Sensing Systems (MANNRRSS) II program. This is a U.S. Department of Energy (DOE)-funded project tasked with utilizing hyperspectral and ancillary electro-optical instrumentation data to create an environmental characterization of an area directly adjacent to the Nevada Test Site (NTS).

  8. Influência do estreitamento do canal vertebral e do tempo para a descompressão na recuperação locomotora de ratos Influencia del estrechamiento del canal vertebral y del tiempo para la descompresión en la recuperación locomotora de ratas The influence of spinal canal narrowing and timing of decompression on locomotion recovery of rats

    Directory of Open Access Journals (Sweden)

    Albert Schiaveto de Souza

    2009-06-01

    motor behavior of rats, as assessing the effect of decompression time on the neurologic recovery of the animals. METHODS: male Wistar rats (n=6 per group were divided into three experimental groups: submitted to laminectomy (T9-T10, Control Group, contusion due to weight drop (10 g from a height of 15 cm, 35% narrowing of the vertebral canal obtained with 0.78 mm thick polycarbonate rods and contusion injury associated with narrowing of the vertebral canal. In this last group, decompression was not performed or it was made after 24 or 72 hours of the surgery, as the animals were divided into subgroups. Rats were sacrificed seven days after surgical procedures. The motor behavior of the animals was assessed in open arena, inclined plane and by means of Basso, Beattie, and Bresnahan (BBB locomotor rating scale, before and after 24, 48 hours and 7 days of surgical procedures. RESULTS: contusion injury, narrowing of the spinal canal and mixed injury impaired the motor behavior of the animals. Surgical decompression (24 and 72 hours did not improve motor recovery as assessed in open arena, BBB scale and inclined plane test. On the other hand, animals injured with weight drop showed better scores on BBB scale and higher angles in the inclined plane when compared to the ones that were injured with narrowing of the vertebral canal and mixed lesion. CONCLUSIONS: spinal cord injury by weight drop and narrowing of the vertebral canal induced alterations on the motor behavior, which did not significantly improve with decompression.

  9. Mechanochemical treatment of polymeric materials. A low environmental impact solution for mixed plastic waste recycling; Il trattamento meccanochimico di materiali polimerici: una soluzione a basso impatto ambientale per il riciclaggio di plastiche eterogenee

    Energy Technology Data Exchange (ETDEWEB)

    Padella, F.; Magini, M.; Masci, A. [ENEA Centro Ricerche Casaccia, Rome (Italy). Dipt. Innovazione

    1999-07-01

    Standard polymeric materials as well as mixtures of them coming from urban wastes, were milled at near room temperature in suitable milling conditions. All the experiments carried out gave a material having a homogeneous fibrous aspect. Structural and thermal analysis of the resulting material clearly shows that the mechanochemical action is able to promote a deep destructuring of the starting networks with a very high energy storage in the milled materials. Further, the fibrous material can be easily consolidated whatever the starting composition of the mixture. preliminary results, coming from mechanical tests on compacted materials, lead to an optimistic conclusion as far as plastic recycling by ball milling is concerned. [Italian] Materiali polimerici standard, cosi' come miscele di materiali plastici provenienti da rifiuti solidi urbani, sono stati macinati a temperatura pressoche' ambiente in opportune condizioni operative. Tutti gli esperimenti hanno prodotto un materiale morfologicamente omogeneo di aspetto fibroso. Le analisi termiche e strutturali condotte sui prodotti mostrano chiaramente come l'azione meccanochimica sia in grado di promuovere una forte destrutturazione del materiale di partenza, accompagnata da un evidente accumulo di energia nel prodotto macinato. In aggiunta, il materiale fibroso puo' essere facilmente consolidato in forme finite, indipendemente dalla composizione di partenza. I risultati preliminari delle prove meccaniche eseguite sui materiali consolidati inducono a conclusioni ottimistiche relativamente all'utilizzo di tecniche di macinazione ad alta energia per il riciclaggio di materiali plastici.

  10. Monossialogangliosídeo transdérmico com laser no tratamento de lesão medular espinal de ratos Transdermal monosialoganglioside with laser in the treatment of spinal cord lesion in rats

    Directory of Open Access Journals (Sweden)

    Fabiano Inácio de Souza

    2013-04-01

    Full Text Available OBJETIVOS: Avaliar os efeitos de monossialogangliosídeos (GM1 administrados com laser por via transdérmica na recuperação da lesão da medula espinal de ratos. MÉTODOS: Quarenta ratos Wistar machos foram submetidos a contusão da medula espinal usando NYU Impactor. No Grupo 1, os ratos receberam 0,2 ml de solução salina diária por via intraperitoneal; no Grupo 2, GM1 foi administrada intraperitonealmente em concentração de 30 mg/kg por dia; no Grupo 3, os ratos foram tratados diariamente com o laser a baixa temperatura sobre a pele, e no Grupo 4, a sessão de laser diária também continha GM1. Todos os grupos foram tratados durante 42 dias. Os animais foram avaliados pela escala funcional de Basso, Baettie e Bresnahan (BBB nos dias 7, 14, 21, 28, 35 e 42 após a lesão, e por histopatologia e potencial motor evocado 42 dias depois da lesão. RESULTADOS: Os animais do Grupo 4 apresentaram escores BBB mais elevados em comparação com os outros grupos. Não houve diferenças entre os grupos ou nas comparações ao longo do tempo. A avaliação histológica não mostrou diferenças, e tampouco foram encontradas diferenças significativas no potencial evocado. CONCLUSÃO: A GM1 associada ao uso de laser a baixa temperatura não mostra resultados superiores no tratamento de lesões da medula espinal de ratos. Nível de Evidência I, Experimental, Estudo Controlado de Animais.OBJECTIVES: to evaluate the effects of monosialoganglioside (gm1 administered transdermally with laser in the recovery of spinal cord injury in rats. METHODS: forty male wistar rats underwent spinal cord contusion using the nyu impactor. in group 1, the rats received 0,2 ml of saline intraperitoneally daily; in group 2, gm1 was administered intraperitoneally at a concentration of 30 mg/kg per day; in group 3, rats were treated daily with laser at low temperature on the skin, and in group 4, the daily laser session also contained gm1. all the groups were treated for 42

  11. Motor cortex and spinal cord neuromodulation promote corticospinal tract axonal outgrowth and motor recovery after cervical contusion spinal cord injury.

    Science.gov (United States)

    Zareen, N; Shinozaki, M; Ryan, D; Alexander, H; Amer, A; Truong, D Q; Khadka, N; Sarkar, A; Naeem, S; Bikson, M; Martin, J H

    2017-11-01

    Cervical injuries are the most common form of SCI. In this study, we used a neuromodulatory approach to promote skilled movement recovery and repair of the corticospinal tract (CST) after a moderately severe C4 midline contusion in adult rats. We used bilateral epidural intermittent theta burst (iTBS) electrical stimulation of motor cortex to promote CST axonal sprouting and cathodal trans-spinal direct current stimulation (tsDCS) to enhance spinal cord activation to motor cortex stimulation after injury. We used Finite Element Method (FEM) modeling to direct tsDCS to the cervical enlargement. Combined iTBS-tsDCS was delivered for 30min daily for 10days. We compared the effect of stimulation on performance in the horizontal ladder and the Irvine Beattie and Bresnahan forepaw manipulation tasks and CST axonal sprouting in injury-only and injury+stimulation animals. The contusion eliminated the dorsal CST in all animals. tsDCS significantly enhanced motor cortex evoked responses after C4 injury. Using this combined spinal-M1 neuromodulatory approach, we found significant recovery of skilled locomotion and forepaw manipulation skills compared with injury-only controls. The spared CST axons caudal to the lesion in both animal groups derived mostly from lateral CST axons that populated the contralateral intermediate zone. Stimulation enhanced injury-dependent CST axonal outgrowth below and above the level of the injury. This dual neuromodulatory approach produced partial recovery of skilled motor behaviors that normally require integration of posture, upper limb sensory information, and intent for performance. We propose that the motor systems use these new CST projections to control movements better after injury. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Magnetic resonance imaging-guided focused ultrasound to increase localized blood-spinal cord barrier permeability.

    Science.gov (United States)

    Payne, Allison H; Hawryluk, Gregory W; Anzai, Yoshimi; Odéen, Henrik; Ostlie, Megan A; Reichert, Ethan C; Stump, Amanda J; Minoshima, Satoshi; Cross, Donna J

    2017-12-01

    Spinal cord injury (SCI) affects thousands of people every year in the USA, and most patients are left with some permanent paralysis. Therapeutic options are limited and only modestly affect outcome. To address this issue, we used magnetic resonance imaging-guided focused ultrasound (MRgFUS) as a non-invasive approach to increase permeability in the blood-spinal cord barrier (BSCB). We hypothesize that localized, controlled sonoporation of the BSCB by MRgFUS will aid delivery of therapeutics to the injury. Here, we report our preliminary findings for the ability of MRgFUS to increase BSCB permeability in the thoracic spinal cord of a normal rat model. First, an excised portion of normal rat spinal column was used to characterize the acoustic field and to estimate the insertion losses that could be expected in an MRgFUS blood spinal cord barrier opening. Then, in normal rats, MRgFUS was applied in combination with intravenously administered microbubbles to the spinal cord region. Permeability of the BSCB was indicated as signal enhancement by contrast administered prior to T1-weighted magnetic resonance imaging and verified by Evans blue dye. Neurological testing using the Basso, Beattie, and Breshnahan scale and the ladder walk was normal in 8 of 10 rats tested. Two rats showed minor impairment indicating need for further refinement of parameters. No gross tissue damage was evident by histology. In this study, we have opened successfully the blood spinal cord barrier in the thoracic region of the normal rat spine using magnetic resonance-guided focused ultrasound combined with microbubbles.

  13. A comment on "pH and the surface tension of water" (J. K. Beattie, A. M. Djerdjev, A. Gray-Weale, N. Kallay, J. Lutzenkirchen, T. Preocanin, A. Selmani, J. Colloid Interface Sci. 422 (2014) 54.)

    Czech Academy of Sciences Publication Activity Database

    Jungwirth, Pavel; Tobias, D. J.

    2015-01-01

    Roč. 448, Jun 15 (2015), s. 593 ISSN 0021-9797 Institutional support: RVO:61388963 Keywords : surface tension * Gibbs adsorption equation * hydroxide * water Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 3.782, year: 2015

  14. Juvenile pen shells (Pinna nobilis) tolerate acidification but are vulnerable to warming, supplement to: Basso, L; Hendriks, Iris; Duarte, Carlos M (2015): Juvenile pen shells (Pinna nobilis) tolerate acidification but are vulnerable to warming. Estuaries and Coasts, 38(6), 1976-1985

    KAUST Repository

    Basso, L; Hendriks, Iris; Duarte, Carlos M.

    2016-01-01

    effects of both stressors on marine invertebrates, particularly on early life stages considered more vulnerable. Disparate responses of their singular and combined effects were reported, highlighting the importance of extending the studies to different

  15. Juvenile pen shells (Pinna nobilis) tolerate acidification but are vulnerable to warming, supplement to: Basso, L; Hendriks, Iris; Duarte, Carlos M (2015): Juvenile pen shells (Pinna nobilis) tolerate acidification but are vulnerable to warming. Estuaries and Coasts, 38(6), 1976-1985

    KAUST Repository

    Basso, L

    2016-01-01

    In the course of this century, rising anthropogenic CO2 emissions will likely cause a decrease in ocean pH, know as ocean acidification, together with an increase of water temperature. Only in the last years, studies have focused on synergetic effects of both stressors on marine invertebrates, particularly on early life stages considered more vulnerable. Disparate responses of their singular and combined effects were reported, highlighting the importance of extending the studies to different species and populations of marine invertebrates. Here, we observed the response of important parameters such as growth, mortality and oxygen consumption of juvenile pen shell Pinna nobilis at supplied pCO2 gas levels of 400 ppm (ambient) and 1000 ppm and at three temperatures (20, 23 and 26 °C) during 36 days. To our knowledge, this is the first study on ocean acidification and temperature effects on juveniles of this species. We show that the two stressors play roles at distinct levels, with pCO2 influencing growth and partially mortality, and temperature increasing mortality rates and oxygen consumption strongly. Therefore, juveniles of P. nobilis are more likely affected by increasing temperature than the pCO2 levels expected by the end of the twenty-first century.

  16. Geohydrology of the near-surface unsaturated zone adjacent to the disposal site for low-level radioactive waste near Beatty, Nevada: A section in Safe disposal of radionuclides in low-level radioactive-waste repository sites; Low-level radioactive-waste disposal workshop, U.S. Geological Survey, July 11-16, 1987, Big Bear Lake, Calif., Proceedings (Circular 1036)

    Science.gov (United States)

    Fisher, Jeffrey M.; Bedinger, Marion S.; Stevens, Peter R.

    1990-01-01

    Shallow-land burial in arid areas is considered the best method for isolating low-level radioactive waste from the environment (Nichols and Goode, this report; Mercer and others, 1983). A major threat to waste isolation in shallow trenches is ground-water percolation. Repository sites in arid areas are believed to minimize the risk of ground-water contamination because such sites receive minimal precipitation and are underlain by thick unsaturated zones. Unfortunately, few data are available on rates of water percolation in an arid environment.

  17. Aerial photographic interpretation of lineaments and faults in late cenozoic deposits in the Eastern part of the Benton Range 1:100,000 quadrangle and the Goldfield, Last Chance Range, Beatty, and Death Valley Junction 1:100,000 quadrangles, Nevada and California

    International Nuclear Information System (INIS)

    Reheis, M.C.; Noller, J.S.

    1991-01-01

    Lineaments and faults in Quaternary and late Tertiary deposits in the southern part of the Walker Lane are potentially active and form patterns that are anomalous with respect to the typical fault patterns in most of the Great Basin. Little work has been done to identify and characterize these faults, with the exception of those in the Death Valley-Furnace Creek (DVFCFZ) fault system and those in and near the Nevada Test Site. Four maps at a scale of 1:100,000 summarize the existing knowledge about these lineaments and faults based on extensive aerial-photo interpretation, limited field investigations, and published geologic maps. The lineaments and faults in all four maps can be divided geographically into two groups. The first group includes west- to north-trending lineaments and faults associated with the DVFCFZ and with the Pahrump fault zone in the Death Valley Junction quadrangle. The second group consists of north- to east-northeast-trending lineaments and faults in a broad area that lies east of the DVFCFZ and north of the Pahrump fault zone. Preliminary observations of the orientations and sense of slip of the lineaments and faults suggest that the least principle stress direction is west-east in the area of the first group and northwest-southeast in the area of the second group. The DVFCFZ appears to be part of a regional right-lateral strike-slip system. The DVFCFZ steps right, accompanied by normal faulting in an extensional zone, to the northern part of the Walker Lane a the northern end of Fish Lake Valley (Goldfield quadrangle), and appears to step left, accompanied by faulting and folding in a compressional zone, to the Pahrump fault zone in the area of Ash Meadows (Death Valley Junction quadrangle). 25 refs

  18. A MAN WHO KNEW MEN: THE MEMOIRS OF MAJ M.G. IND

    African Journals Online (AJOL)

    interpolations or commentary forms an unduly heavy proportion of the article; ...... The surrender of the German Fleet, Admiral Beatty reading out the terms. Fore Cabin HMS Queen ... until he produced documentary evidence in support of his ...

  19. to view fulltext PDF

    Indian Academy of Sciences (India)

    Unknown

    more technical contributions to genetics and evolutionary biology. In this second ... accounts of the remarkable years in Dobzhansky's lab, the research on ... author, John Beatty, is 'pleased to offer this small contri- bution to the festschrift ...

  20. Human Factors Influencing Decision Making

    Science.gov (United States)

    1998-07-01

    and Einhom (1991); Zeelenberg et al. (1997). This environmental context also makes it difficult to associate measured personality traits with specific... Zeelenberg and Beattie5 (1997): People are motivated to minimize post-decision regret. As a result people can become risk averse or risk seeking...188-201), Ablex, Norwood NJ, 1993. 5 Zeelenberg M. and J. Beattie. "Consequences of regret aversion 2: additional evidence for effects of feedback on

  1. Competition in the Dutch consumer credit market

    NARCIS (Netherlands)

    Toolsema-Veldman, Linda

    2002-01-01

    This paper considers the degree of competitiveness of the Dutch consumer credit market. We use the well-known Bresnahan-Lau method that estimates a structural model consisting of a demand relation and a supply relation, based on aggregate data. The level of competition is derived from the estimated

  2. Competition in the Dutch consumer credit market

    NARCIS (Netherlands)

    Toolsema-Veldman, Linda

    2001-01-01

    This paper considers the degree of competitiveness of the Dutch consumer credit market. We use the well-known I Bresnahan-Lau method that estimates it structural model consisting of a demand relation and a supply relation, based on aggregate data. The level of compelition is derived from the

  3. Persian Speakers' Use of Refusal Strategies across Politeness Systems

    Science.gov (United States)

    Salmani Nodoushan, Mohammad Ali

    2016-01-01

    This study aimed at investigating the preferred refusal strategies in Persian. 3047 refusals collected by 108 field workers as well as 376 refusals collected through face to face interviews were analyzed and classified according to the descriptions proposed by Liao (1994) and Liao and Bresnahan (1996). The frequencies of the resulting direct and…

  4. Still Another Book of Small-Scale Motets

    OpenAIRE

    Rodríguez-Garcia, Esperanza

    2016-01-01

    UID/EAT/00693/2013 PTDC/CPC-MMU/0314/2014 ‘Still another book of small-scale motets: Sebastián Raval’s Motecta (1600)’ Lodovico Viadana’s Cento concerti ecclesiastici (Venice: Giacomo Vincenti, 1602), a collection of small-scale motets with basso continuo, is still considered ‘chronologically the first publication to include a basso continuo with sacred vocal music’. It has become the epitome of the advent of the Baroque in Italian sacred music. But, as has been argued in recent times, ...

  5. Verbs: Some properties and their consequences for agrammatic Broca's aphasia

    NARCIS (Netherlands)

    Bastiaanse, Y.R.M.; Rispens, J.E.; Ruigendijk, E.; Juncos Rabadán, O.; Thompson, C.K.

    2002-01-01

    It has repeatedly been shown that agrammatic Broca's aphasics have serious problems with the retrieval of verbs on action naming tests (Miceli, Silveri, Villa & Caramazza, 1984; Kohn, Lorch Pearson, 1989; Basso, Razzano, Faglioni Zanobio, 1990; Jonkers, 1998; Kim & Thompson, 2000). Less attention

  6. Field Note

    African Journals Online (AJOL)

    the broadcast spawning coral Acropora millepora. Marine Ecology Progress Series 362: 129-137. Benzoni F, Basso D, Caragnano A, Rodondi G (2011) Hydrolithon spp. (Rhodophyta, Corallinales) overgrow live corals (Cnidaria, Scleractinia) in Yemen. Marine Biology 158: 2419-2428. Figure 1. Hydrolithon sp. overgrowing ...

  7. Salvianolic Acid B Ameliorates Motor Dysfuntion in Spinal Cord ...

    African Journals Online (AJOL)

    Department of Surgery, The First Affiliated Hospital of Dalian Medical ... During the treatment, footprint analysis (FA), inclined plane test (IPT), Basso- ... Conclusion: The beneficial effect of motor function recovery was observed in SCI rats ... paralysis. The other 10 rats without SCI were housed in two cages as healthy control.

  8. The Permanent People’s Tribunals and indigenous people’s struggles in Mexico : Between coloniality and epistemic justice?

    NARCIS (Netherlands)

    R.A. Icaza Garza (Rosalba)

    2015-01-01

    markdownabstractOn 21 October 2011, hundreds of Mexican civil society organizations formally submitted a petition to the Lelio e Lisli Basso Foundation in Rome to justify the opening of a Mexican Chapter of the Permanent People’s Tribunals (PPT). The PPT was established in 1979 as the successor to

  9. Reflexive Photography, Attitudes, Behavior, and CALL: ITAs Improving Spoken English Intelligibility

    Science.gov (United States)

    Wallace, Lara

    2015-01-01

    Research in the field of Computer-Assisted Language Learning (CALL) has frequently taken a top-down approach when investigating learners' attitudes and behavior, both in the course as well as for their personal use. Suggestions are given for use of technology, and future research (Beatty, 2010; Levy & Stockwell, 2006). One perspective that has…

  10. The Battle of Savo Island August 9th, 1942. Strategical and Tactical Analysis. Part I

    Science.gov (United States)

    1950-01-01

    Department publIcation SSC-677, Survey of the Bolcmon Islands. March 16, 1943, Confidential. *OCTW 62 personal latter to Captain RC. Parker, USN(Ret...cakiral Jellicu had si&Unalled Ad- miral Oqattr "Wh•re !e the anek-q’s battles Fleet?" and Lsirl Beatty •had repliid la a most v& omnic kid inoomplete m

  11. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (81st, Baltimore, Maryland, August 5-8, 1998). Mass Communication and Society.

    Science.gov (United States)

    Association for Education in Journalism and Mass Communication.

    The Mass Communication and Society section of the Proceedings contains the following 19 papers: "Talk Radio as Forum and Companion: Listener Attitudes and Uses and Gratifications in Austin, Texas" (John Beatty); "'Willingness to Censor': Developing a Quantitative Measurement across Speech Categories and Types of Media"…

  12. The Use of Ferroelectric Ceramics to Charge Small Capacitor Banks

    Science.gov (United States)

    2017-09-01

    CENTER D BLANKENBILLER 106 DIR US ARL (PDF) RDRL DP RC BECKER TW BJERKE RDRL WMM JH BEATTY RDRL WMM A JJ LA SCALA...KORNECKI SM WALSH RDRL WMM E VL BLAIR SM KILCZEWSKI JC LASALVIA PJ PATEL JJ SWAB LR VARGAS-GONZALEZ RDRL WML B

  13. An Extensive comparison of operating-lease capitalisation approaches and their unavoidable assumptions : Are further disclosures desirable?

    NARCIS (Netherlands)

    Lückerath – Rovers, M.; Bos, de A.

    2009-01-01

    Previous research of Imhoff, Lipe and Wright (1991), Beattie, Edwards and Goodacre (1998) and others has shown that the capitalisation of operating leases on the balance sheet has a major impact on the accounting ratios. This empirical study expands previous research on two issues. First, we refine

  14. LLW Notes, Volume 12, Number 1

    International Nuclear Information System (INIS)

    Norris, C.; Brown, H.; Colsant, J.; Lovinger, T.; Scheele, L.; Shaker, M.A.

    1997-01-01

    Contents include articles entitled: Suit against Envirocare sparks investigations: Formal petition filed with NRC; Group alleges misconduct by USGS re Beatty study; EPA rescinds NESHAPs subpart 1; Northwest Compact executive director changes jobs; New forum participant for the state of New Jersey; and Director of North Carolina division of radiation control retires

  15. DOE role in support of a small-scale appropriately distributed technology. Official transcript of public briefing and addendum

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-08-01

    This report first lists 94 questions raised relative to the DOE public briefing on appropriate technology. The keynote speaker was John O'Leary who gave some perceptions of the future. The introductory speech was given by Phillip S. Hughes. Panel members from DOE who provided answers to the questions were: Maxine Savitz, John Deutch, Robert Thorne, and Donald Beattie. (MCW)

  16. LLW Notes, Volume 12, Number 1

    Energy Technology Data Exchange (ETDEWEB)

    Norris, C.; Brown, H. [eds.; Colsant, J.; Lovinger, T.; Scheele, L.; Shaker, M.A.

    1997-01-01

    Contents include articles entitled: Suit against Envirocare sparks investigations: Formal petition filed with NRC; Group alleges misconduct by USGS re Beatty study; EPA rescinds NESHAPs subpart 1; Northwest Compact executive director changes jobs; New forum participant for the state of New Jersey; and Director of North Carolina division of radiation control retires.

  17. 76 FR 18921 - Land Disposal Restrictions: Nevada and California; Site Specific Treatment Variances for...

    Science.gov (United States)

    2011-04-06

    ... final actions to both issue a site- specific treatment variance to U.S. Ecology Nevada (USEN) in Beatty... Facility is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays. The... action and anticipate no adverse comment. Based on the information and data submitted by the petitioner...

  18. Reliving the History of Compensatory Education: Policy Choices, Bureaucracy, and the Politicized Role of Science in the Evolution of Head Start

    Science.gov (United States)

    Beatty, Barbara; Zigler, Edward

    2012-01-01

    In this article, Edward Zigler, interviewed by Barbara Beatty, talks about a turning point in the history of Head Start that reveals how policy choices, bureaucracy, and science came together when he was told to phase out the program in 1970. New to Washington, Zigler learned that President Richard M. Nixon's domestic policy advisor Daniel Patrick…

  19. 77 FR 52293 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition To List Mimulus...

    Science.gov (United States)

    2012-08-29

    ....) long, with spreading petals and an open throat (Beatty et al. 2003, p. 14); they bloom in mid-July... decades along the Colorado Front Range Urban Corridor, and are projected to increase another 26.5 percent... from direct fire impacts, ecology of the site was reportedly altered in its hydrology and vegetation...

  20. 50 Detecting adenosine triphosphatase 6 point mutations that may ...

    African Journals Online (AJOL)

    mutations at codons for the key residues Lys 260, Leu263, Gln266, Ser769 .... agarose gel and visualized under UV transillumination after treatment with ..... Li, W., Mo, W., Shen, D., Sun, L., Wang, J., Lu, S., Gitschier, J.M. & Zhou, B. (2005) Yeast ... Nagamune, K., Beatty, W.L., & Sibley, D. (2007) Artemisinin induces Calcium ...

  1. Strategic Performance Options in Professional Service Organizations

    NARCIS (Netherlands)

    Doorewaard, J.A.C.M.; Meihuizen, H.E.

    2000-01-01

    In the current debate on HRM and organisational performance (Mahoney and Pandian, 1992; Storey, 1992; Paauwe, 1994; Wright et al, 1994; Flood et al, 1995; Becker and Gerhardt, 1996; Boxall, 1996; Mueller, 1996; Beatty and Schneider, 1997; Coff, 1997; Guest, 1997; Paauwe and Richardson, 1997; Boxall

  2. [Socio-economic context in the Lower Iseo Lake area after World War II].

    Science.gov (United States)

    Simoncini, Carlo

    2007-01-01

    In the second part of the 20th century, the Basso Sebino Area (Northern Italy) underwent a transformation into an industrial context. The first factories were engaged in the production of textiles, clothes and pasta. This was followed by a major development of mechanic, plastic and rubber industry. The latter activity was concentrated on the production of buttons. This text describes the evolution of the unions'activity in order to obtain a more decent salary and better working conditions in all productive areas. Within this reality, the production of asbestos goods started in 1950 in the Colombo enterprise, run by Rinaldo Colombo, The latter was also the manager of the chrysotile quarry in Balangero, province of Torino (the biggest asbestos mine in Western Europe). Through these connections, asbestos was conveyed from Balangero to the Basso Sebino Area in such a way that most of the asbestos chain (extraction, processing of asbestos goods and sales) was under the control of the same firm.

  3. Holocene paleoclimate inferred from salinity histories of adjacent lakes in southwestern Sicily (Italy)

    Science.gov (United States)

    Curry, B Brandon; Henne, Paul; Mezquita-Joanes, Francesc; Marrone, Federico; Pieri, Valentina; La Mantia, Tommaso; Calo, Camilla; Tinner, Willy

    2016-01-01

    Marked uncertainties persist regarding the climatic evolution of the Mediterranean region during the Holocene. For instance, whether moisture availability gradually decreased, remained relatively constant, or increased during the last 7000 years remains a matter of debate. To assess Holocene limnology, hydrology and moisture dynamics, the coastal lakes Lago Preola and Gorgo Basso, located in southwestern Sicily, were investigated through several stratigraphic analyses of ostracodes, including multivariate analyses of assemblages, transfer functions of salinity, and biochemical analyses of valves (Sr/Ca, δ18O and δ13C). During the early Holocene, the Gorgo Basso and Lago Preola ostracode records are similar. After an initial period of moderate salinity (1690–6100 mg/l from ca. 10,000–8190 cal yr BP), syndepositional or diagenetic dissolution of ostracode valves suggests that salinity declined to Greek civilization took root in Sicily (2600 cal yr BP), and it completely dominates the record during Roman occupation (roughly 2100 to 1700 cal yr BP). These freshwater conditions at Gorgo Basso suggest high effective moisture when evergreen olive-oak forests collapsed in response to increased Greco-Roman land use and fire. Ostracode valve geochemistry (Sr/Ca, δ18O) suggests significant changes in early vs. late Holocene hydrochemistry, either as changes in salinity or in the seasonality of precipitation. Harmonizing the autecological and geochemical data from Gorgo Basso suggests the latter was more likely, with relatively more late Holocene precipitation falling during the spring, summer, and fall, than winter compared to the early Holocene. Our ostracode-inferred paleosalinity data indicate that moisture availability did not decline during the late Holocene in the central Mediterranean region. Instead, moisture availability was lowest during the early Holocene, and most abundant during the late Holocene.

  4. Einstein on Race and Racism, presented by Fred Jerome and Rodger Taylor

    Science.gov (United States)

    Jerome, Fred; Taylor, Rodger

    2007-10-01

    It is little-known that physicist Albert Einstein strongly held the view that ``Racism is America's worst disease.'' Einstein was active in the fight against racism from the 1930's until his death in 1955. Included among his friends were a number of important Afro-American figures, including the educator W.E.B. DuBois, the actor and basso profundo singer Paul Robeson, and the soprano Marian Anderson. Based on the authors' work ``Einstein on Race and Racism.''

  5. Monitoraggio in continuo di strutture e del territorio mediante la tecnologia GNSS

    OpenAIRE

    Poluzzi, Luca

    2016-01-01

    Al giorno d’oggi, la tecnologia GNSS può essere uno strumento utile, non solo in ambito di navigazione, ma anche per applicazioni di posizionamento di precisione come il monitoraggio di strutture o del territorio. Questa tecnica permette un controllo in continuo, anche da remoto, e ha un costo relativamente basso sia per quanto riguarda le strumentazioni che per gli aspetti di materializzazione e mantenimento. Nell’ottica di utilizzare la tecnologia GNSS per applicazioni di monitoraggio, il p...

  6. L’Area archeologica di Santusangius-Serrenti (Sud Sardegna e la questione del ʽvillaggio scomparsoʼ di Monpusi

    Directory of Open Access Journals (Sweden)

    Daniele Carta

    2017-11-01

    Full Text Available Riassunto. Lo studio delle fonti storico-archivistiche e delle evidenze materiali in località Bruncu Pubusa/Santusangius, importante sito tra l’Età nuragica e quella romana, pone in luce come quello che alcuni Autori ritengono essere un villaggio spopolato nel basso medioevo (Monpusi non sia in realtà mai esistito in tale periodo e con il nome citato.

  7. Il fuoco della fusione termonucleare controllata

    CERN Document Server

    Caldirola, Piero; Sindoni, Elio

    1984-01-01

    Per realizzare la fusione termonucleare controllata, cioè catturare e dominare il fuoco che accende gli astri, e ottenere così una nuova fonte di energia praticamente illimitata e a basso costo, si richiede uno sforzo collettivo e unitario globale: non esiste infatti nazione al mondo che sia in grado, singolarmente presa, di affrontare il problema, sia per le risorse finanziarie necessarie all'impresa sia per il numero dei ricercatori che dovranno dedicarvisi.

  8. L'Epitafio inedito di Nicasia scolastica rinvenuto a Rihana

    OpenAIRE

    Ibba, Antonio

    1997-01-01

    L'epitafio inedito di Nicasia scolastica è verosimilmente una nuova testimonianza epigrafica perlomeno del basso impero, con grande probabilità di ambito cristiano, un dato che concorda con la circostanza che ad Uchi Maius abbiamo testimonianza sia di iscrizioni che di una basilica paleocristiana; viene qui ricordata uan donna morta ad appena venti anni, Nicasia, secondo l'uso allora corrnte del nome unico al posto dei tria nomina.

  9. FOOD SAFETY AND QUALITY IN DEVELOPING COUNTRIES: THE ROLE OF LACTIC ACID BACTERIA

    OpenAIRE

    ANGRI, MATTEO

    2016-01-01

    La sicurezza e la qualità degli alimenti sono tutt’ora un problema critico per i paesi in via di sviluppo. Le diete a basso contenuto di acido folico, per esempio, possono causare gravi problemi di salute, soprattutto nei bambini. Gravi disturbi legati al tubo neurale (DTN) nei neonati possono derivare infatti da madri che hanno insufficiente apporto di acido folico (400-600 g / giorno) durante il periodo di gravidanza. Inoltre, se non adeguatamente protetti o trattati, I prodotti alimentari ...

  10. O stilu i kulturnom značenju Marulićeve Poslanice papi Adrijanu VI.

    OpenAIRE

    Cattaneo, Ruggero

    2008-01-01

    Nella comunicazione quotidiana assistiamo oggi a un singolare rinnovamento del genere epistolografico, tutte le volte che scriviamo (digitiamo) e scambiamo messaggi di posta elettronica (e-mail) privati o ufficiali, o anche, a un più basso ma non meno vitale livello stilistico, messaggi SMS, che somigliano talora a mini-lettere, o più spesso a epigrammi. Sono le nuove, ma ormai onnipresenti forme della comunicazione elettronica, che danno spazio anche a una parola più intima e confidenziale, ...

  11. Fumo attivo e passivo, consumo di caffè ed effetti sulla gravidanza: uno studio caso controllo in Italia

    Directory of Open Access Journals (Sweden)

    G. Fantuzzi

    2003-05-01

    Full Text Available

    Obiettivi: alcune abitudini di vita possono influenzare lo sviluppo fetale durante il periodo di gravidanza. Lo scopo di questo studio è stato quello di indagare gli effetti di alcune abitudini voluttuarie sulle nascite premature e sul basso peso alla nascita.

    Metodi: è stato condotto uno studio caso controllo nel periodo ottobre 1999 settembre 2000 in 9 città italiane (Genova, Udine, Modena, Parma, Siena, Roma, L’Aquila, Napoli e Catania. Sono stati identificati come casi 525 neonati pretermine (26ma, 38ma settimana di gravidanza e 317 neonati a termine ma con peso ‹ al 10° P. Sono stati arruolati come controllo 871 bambini nati a termine e normopeso. Le informazioni relative all’esposizione al fumo attivo e passivo e al consumo di caffè e i dati personali sono stati raccolti attraverso un apposito questionario.

    Risultati: dai risultati dell’analisi univariata è emerso un maggior rischio di basso peso alla nascita nei bambini le cui madri avevano fumato durante l’ultimo trimestre di gravidanza, con un chiaro effetto dose risposta. (OR: 2.09, 95% CI:1.45 - 3.00 per 1 9 sigarette/giorno, e OR= 2.76, 95% CI: 1.67 - 4.45 per 10 ed oltre sigarette al giorno. Anche la nascita pretermine sembra influenzata dall’abitudine tabagica della madre anche se in modo meno evidente. OR: 1.47, 95% CI: 1.05 - 2.04 per 1 9 sigarette/giorno e un OR: 1,30 95% CI: 0.78 - 4.81 per 10 e più sigarette/giorno. Per quanto riguarda l’esposizione al fumo passivo (più di due fumatori nelle abitazioni è stata osservata una positiva associazione con il basso peso alla nascita (OR: 3.05, 95% CI: 1.19 - 7.79. Il consumo di caffè non sembra influenzare lo sviluppo fetale. La regressione logistica multipla ha confermato solo l’influenza del fumo attivo della madre sulla basso peso alla nascita. (AOR= 2.49, 95% CI: 1.74 - 3.56.

    Conclusioni: questo studio conferma che

  12. Characteristics of low-level radioactive waste disposed during 1987--1989

    International Nuclear Information System (INIS)

    Roles, G.W.

    1990-12-01

    This report presents the volume, activity, and radionuclide distributions in low-level radioactive waste (LLW) disposed during 1987 through 1989 at the commercial disposal facilities located near Barnwell, SC, Richland, WA, and Beatty, NV. The report has been entirely assembled from descriptions of waste provided in LLW shipment manifests. Individual radionuclide distributions are listed as a function of waste class, of general industry, and of waste stream. In addition, information is presented about disposal of wastes containing chelating agents, about use of solidification media, about the distribution of radiation levels at the surfaces of waste containers, and about the distribution of waste container sizes. Considerably more information is presented about waste disposed at the Richland and Beatty disposal facilities than at the Barnwell disposal facility

  13. Publishing at "the request of friends": Alexander Ross and James Beattie’s Authorial Networks in Eighteenth-Century Aberdeen

    OpenAIRE

    Ruth Knezevich

    2016-01-01

    Authorship in eighteenth-century Aberdeen often functioned differently than in London and Edinburgh. The Aberdeen model of authorship relied heavily on an intricate network of booksellers, patrons, readers, and critics involved in preparing a text to be consumed by the reading public; yet the prevailing narrative of the author as rising to “inspired genius” disallows for this network. The authorial career of poet Alexander Ross and his friend/mentorship with philosopher James Beattie offers a...

  14. 1980 state-by-state assessment of low-level radioactive wastes shipped to commercial disposal sites

    International Nuclear Information System (INIS)

    1982-06-01

    Information is presented on the volumes, curie values, sources, and disposal of low-level radioactive wastes (LLW) in each state. The wastes are segmented into 2 broad categories - institutional/industrial and commercial power reactor wastes. The volumes and curie values were obtained from the commercial site operators. The percentage of LLW disposed of at each of the 3 operating disposal sites located at Barnwell, SC, Beatty, NV, and Richland, WA are included

  15. Installation Restoration Program Records Search for Nellis Air Force Base, Nevada.

    Science.gov (United States)

    1982-06-01

    solution has caused a secondary o ypsiferous 20,000± Bird Spring Formation, Monte Cristo enlargement of joints and fractures. rocks, and Sultan...activities included air-to-air gunnery training and ground firing using rail- mounted targets. A large portion of the range is no longer active. The pistol...is a building rented from a trailer court operation in Beatty, Nevada, 120 miles north- west of Nellis AFB. Hazardous waste generation does not occur

  16. An Extensive comparison of operating-lease capitalisation approaches and their unavoidable assumptions : Are further disclosures desirable?

    OpenAIRE

    Lückerath – Rovers, M.; Bos, de, A.

    2009-01-01

    Previous research of Imhoff, Lipe and Wright (1991), Beattie, Edwards and Goodacre (1998) and others has shown that the capitalisation of operating leases on the balance sheet has a major impact on the accounting ratios. This empirical study expands previous research on two issues. First, we refine the capitalisation methods that have been developed by previous researchers. Second, we expand the focus from the relevance criteria of operating-lease information to the completeness-criterion of ...

  17. Energy Policies for Resilience and National Security.

    Science.gov (United States)

    1981-10-01

    consequences: cancer , sterility, and gross birth defects...for many years after...release." [Joint Committee on Defense Production 1977:1:29] Since many of these...emergency generators, and thirteen other establishments, mainly medical , needed emergency generators repaired. Con Ed dispatched 18 of its 50 portable...scrap metal were il- licitly dug up and sold from a waste dump in Beatty, Nevada [NRC 1976a]. "Vast quantities of cannabis resin were smuggled into

  18. Does IFRIC 15 Matter? The Decision Usefulness of Accelerated Revenue and Earnings Recognition

    OpenAIRE

    Lau Chee Kwong

    2013-01-01

    The newly issued IFRIC 15 Agreements for the Construction of Real Estate are likely to cause Malaysian property developers to change their revenue recognition policy from a stage-of-completion basis (accelerated) to a completion basis (conservative). In the US, consistent with the approach taken by the Financial Accounting standards Board (FASB), Altomuro, Beatty and Weber (2005) found that reported earnings based on accelerated revenue recognition are value relevant. The subsequent eliminati...

  19. Summary of chemical data from onsite and laboratory analyses of groundwater samples from the surficial aquifer, Las Vegas, Nevada, April and August 1993 and September 1994

    Science.gov (United States)

    Reddy, Michael M.; Gunther, Charmaine D.

    2012-01-01

    This report presents a summary of data collected during April and August 1993 and September 1994. These results are to be used as a wet-site analog to southern Nevada soils located at the Amargosa Desert Research Site near Beatty, Nevada. The samples were collected and analyzed in conjunction with the Nevada Basin and Range study unit of the U.S. Geological Survey, National Water-Quality Assessment Program (NAWQA).

  20. Proceedings of a Workshop on V/STOL Aircraft Aerodynamics. Volume I. Held at Naval Postgraduate School Monterey, California 16-18 May 1979,

    Science.gov (United States)

    1979-05-18

    jets in a crossflow being conducted by the Computational Mechanics Corp. The Vought VAPE program will incorporate - in addition to the Wooler-Ziegler...Beatty Vought Corporation Dallas, TX This paper describes the V/STOL Aircraft Propulsive Effects Computer Program ( VAPE ), developed at the Vought...regions of flight. The VAPE program is capable of evaluating: o effects of relative wind about the aircraft o effects of propulsive lift jet entrainment

  1. Pupillary Response as an Indicator of Processing Demands Within a Supervisory Control Simulation Environment

    Science.gov (United States)

    2015-05-07

    Yerkes, R.M., and Dodson, J.D. (1908). The relation of strength of stimulus to rapidity of habit -formation. Journal of comparative neurology and psychology 18, 459-482. ...the amount of mental effort exerted (Kahneman, 1973; Beatty & Lucero-Wagoner, 2000; Andreassi, 2007). The vast majority of these studies , however...of this initial study , the authors were interested in investigating whether pupillometry data collected in a realistic UAV supervisory control

  2. Western North Pacific Monsoon Depressions: Formation, Structure, and Transition to Tropical Cyclones

    Science.gov (United States)

    2015-09-01

    produced total rainfall accumulations approaching 3,000 mm in the Central Mountain Range. This record-breaking rainfall caused landslides over the...mountains, including one landslide that destroyed the entire Shiao-Lin village, resulting in more than 650 deaths and causing severe flooding over most...Online analysis enhances use of NASA Earth science data. Eos, Trans. AGU, 88, 14–17. Beattie, J. C., and R. L. Elsberry, 2010: Conceptual model of

  3. Estimating a theoretical model of state banking competition using a dynamic panel: the Brazilian case

    Directory of Open Access Journals (Sweden)

    Fábio A. Miessi Sanches

    2009-03-01

    Full Text Available In this paper we set up a model of regional banking competition based on Bresnahan (1982, Lau (1982 and Nakane (2002. The structural model is estimated using data from eight Brazilian states and a dynamic panel. The results show that on average the level of competition in the Brazilian banking system is high, even tough the null of perfect competition can be rejected at the usual significance levels. This result also prevails at the state level: Rio Grande do Sul, São Paulo, Rio de Janeiro, Pernambuco and Minas Gerais have high degree of competition.

  4. Contaminant migration at two low-level radioactive waste sites in arid western United States - a review

    International Nuclear Information System (INIS)

    Wilshire, H.G.; Friedman, I.

    1999-01-01

    Contamination of the unsaturated zone and ground water at the Beatty, Nevada and Richland, Washington low-level radioactive waste sites shows that pathways exist for rapid lateral and vertical migration of contaminants through unconsolidated clastic sediments that comprise the 100 m-thick unsaturated zones of those arid disposal sites. Disposal of liquid wastes at the Beatty site until 1975 may have contributed to rapid migration of contaminants, but negligible amounts of liquid wastes reportedly were disposed at the Richland LLRW site and similar problems of contaminant migration exist. Pathways for vertical migration in the unsaturated zone include fractures and, at Richland, clastic dikes; lateral migration pathways likely are facies-controlled. Disturbance of the disposal sites contributed to increased infiltration of the unlined waste trenches after closure; simulations that used Beatty sample data show dramatic increases in recharge with disturbances necessary to develop the site. Because neither and arid climate nor presence of a thick unsaturated zone offer effective barriers to ground-water contamination, reliance on those factors at proposed sites such as Ward Valley, California and elsewhere is unwarranted. (orig.)

  5. Acerca de la localidad tipo y la distribución geográfica de Melanophryniscus klappenbachi Prigione & Langone, 2000 (Anura: Bufonidae

    Directory of Open Access Journals (Sweden)

    Baldo, Diego

    2001-12-01

    Full Text Available Dada la distribución geográfica de esta especie en Argentina, Prigioni y Langone (op. cit. sugieren que las citas de M. stelzneri fulvoguttatus para las provincias de Santa Fe (Baldo y Arzamendia, 1997 y Santiago del Estero (Basso y Williams, 1996 y para la localidad formoseña de Bartolomé de las Casas (Gallardo, 1961; 1966 debían ser reexaminadas. Del examen del material en el que se basaron dichas citas, concluyo que pertenecen a M. klappenbachi.

  6. L’ORDO IUDICIARIUS E I VERBA DIMINUENTIA IURIS ORDINEM

    Directory of Open Access Journals (Sweden)

    José Neftalí Nicolás García

    2017-06-01

    Full Text Available Il proceso sommario, frutto di un lungo lavoro sinergico realizzato dai legislatori medievali dell’uno e dell’altro diritto, costituí un processo alternativo al solenne, più agile e veloce, del quale la Saepe Contingit rappresenta il paradigma che raggiunge la sua piena maturazione scientifica con il trattato di Bartolo da Sassoferrato sulla Costituzione Ad Reprimendum. Questo articolo si propone l’obiettivo di ripercorrere brevemente i passi che conducono all’emersione del rito sommario nello Ius Commune del Basso Medioevo.

  7. Rapid Translation of a Novel and Potent Vaccine in HER2+ Metastatic Breast Cancer Patients

    Science.gov (United States)

    2013-10-01

    Xia3, Neil Spector2,3, Larry S Barak4, Timothy M Clay5, Takuya Osada2, Erika Hamilton6, Kimberly Blackwell6, Amy C Hobeika2, Michael A Morse2,3, H Kim...Zhang L, Boehm MF, Fritz LC, Burrows FJ: A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 2003, 425:407...410. 13. Zhang H, Burrows F: Targeting multiple signal transduction pathways through inhibition of Hsp90. J Mol Med (Berl) 2004, 82:488-499. 14. Basso

  8. Communication and co-operation within and between local authorities - an attempt to quantify management practices and their effect on the air quality management process

    Energy Technology Data Exchange (ETDEWEB)

    Beattie, C.I.; Ling, K.; Longhurst, J.W.S. [Univ. of the West of England, Faculty of Applied Sciences, Bristol (GB)] [and others

    1999-07-01

    Air quality management is being implemented in England according to the Environment Act 1995 and the UK National Air Quality Strategy (NAQS). Being undertaken at a local level, it is designed to address air quality issues in a holistic way. One of the possible barriers to the successful implementation of the NAQS requirements is lack of communication within the local authorities (Beattie et al). This paper presents an analysis of the factors affecting this communication process. Issues identified as important include officer training, the influence of regional group support and the role of internal groups in facilitating or enhancing the communication process. (Author)

  9. Design and operational considerations of United States commercial nea-surface low-level radioactive waste disposal facilities

    International Nuclear Information System (INIS)

    Birk, Sandra M.

    1997-01-01

    Low-level radioactive waste disposal standards and techniques in the United States have evolved significantly since the early 1960's. Six commercial LLW disposal facilities(Barnwell, Richland, Ward Valley, Sierra Blanca, Wake County and Boyd County) operated and proposed between 1962 and 1997. This report summarizes each site's design and operational considerations for near-surface disposal of low-level radioactive waste. These new standards and mitigating efforts at closed facilities (Sheffield, Maxey Flats, Beatty and West Valley) have helped to ensure that the public has been safely protected from LLW. 15 refs

  10. Isotopic analysis of radioactive waste packages (an inexpensive approach)

    International Nuclear Information System (INIS)

    Padula, D.A.; Richmond, J.S.

    1983-01-01

    A computer printout of the isotopic analysis for all radioactive waste packages containing resins, or other aqueous filter media is now required at the disposal sites at Barnwell, South Carolina, and Beatty, Nevada. Richland, Washington requires an isotopic analysis for all radioactive waste packages. The NRC (Nuclear Regulatory Commission), through 10 CFR 61, will require shippers of radioactive waste to classify and label for disposal all radioactive waste forms. These forms include resins, filters, sludges, and dry active waste (trash). The waste classification is to be based upon 10 CFR 61 (Section 1-7). The isotopes upon which waste classification is to be based are tabulated. 7 references, 8 tables

  11. H.R. 5477: A Bill to provide the States that are not members of interstate compacts for the disposal of low-level radioactive waste may not site low-level radioactive waste disposal facilities within 60 miles of an international border, and for other purposes. Introduced in the House of Representatives, One Hundredth First Congress, Second Session, August 3, 1990

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    Also applicable to all states, whether interstate compact members or not, are the following restrictions on the siting of low-level radioactive waste disposal facilities. Such facilities may not be sited: within 25 miles of the critical habitat of a species listed as endangered or threatened; within 10 miles of an area determined to be a wetland; or within 10 miles of an area of archaeological importance. The act exempts the three facilities in current operation, namely, those located at Barnwell, North Carolina; Richland, Washington; and Beatty, Nevada

  12. References

    OpenAIRE

    2018-01-01

    Aldridge, H., Kenway, P. and Born, T. (2015), ‘What Happened to Poverty Under the Coalition’. New Policy Institute. Armour, R. (2014) ‘Charity Shops Buck Trend’, http://thirdforcenews.org.uk,24 March 2014. Beatty, C. and Fothergill, S. (2016), The Uneven Impact of Welfare Reform. The Financial Losses to Places and People, Centre for Regional and Social Economic Research and Sheffield Hallam University, https://www4.shu.ac.uk/research/cresr/sites/shu.ac.uk/files/welfare-reform-2016_1.pdf Belfi...

  13. Large-scale bioprospecting of cyanobacteria, micro- and macroalgae from the Aegean Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Montalvao, S.; Demirel, Z.; PrabhaDevi; Lombardi, V.; Hongisto, V.; Perala, M.; Hattara, J.; Imamoglu, E.; Tilvi, S.; Turan, G.; Dalay, M.C.; Tammela, P.

    cells (inhibition of growth 87%) andsimilar effect has previously been reported for this species (Mhadhebi et al. 2014). Recent publications(Mikami and Hosokawa 2013; Mhadhebi et al. 2014) have provided evidence that some compounds and pigments present..., Mathur EJ. Bioprospecting ethics & benefits: a model for effective benefit- sharing. Ind Biotechnol 2005;1:255–9. http://dx.doi.org/ 10.1089/ind.2005.1.255. [2] Beattie AJ, Hay M, Magnusson B, de Nys R, Smeathers J, Vincent JFV. Ecology...

  14. Britain at CERN

    CERN Multimedia

    CERN Press Office. Geneva

    1996-01-01

    On 8 October, H.E. Mr David Beattie, British Ambassador to Switzerland, Mr John R. Nichols, H.M. Consul-General in Geneva and, Prof. Christopher Llewellyn Smith, CERN*'s Director General, formally opened the industrial exhibition of thirty-three British hi-tech companies at CERN, which takes place from 8 to 11 October, 1996. The exhibition offers British companies the opportunity to display their products in fields that are of immediate importance to the scientists, engineers and technicians working at CERN, and also to scientists from non-Member States who take part in research projects at CERN.

  15. Perry Nuclear Plant's Plans for on-site storage

    International Nuclear Information System (INIS)

    Ratchen, J.T.

    1993-01-01

    Because of current radwaste disposal legislation and the eventual denial of access to the Barnwell, Richland, and Beatty burial sites, it was imperative for the Perry nuclear power plant to develop alternative means for handling its generated radioactive waste. The previous radwaste facilities at Perry were developed for processing, packaging, short-term storage, and shipment for burial. In order to meet the changing needs, new facilities have been constructed to handle the processing, packaging, and 5-yr interim storage of both dry active waste (DAW) and dewatered or solidified resin, filter media, etc

  16. Response to a widespread, unauthorized dispersal of radioactive waste in the public domain

    International Nuclear Information System (INIS)

    Wenslawski, F.A.; North, H.S.

    1979-01-01

    In March 1976 State of Nevada radiological health officials became aware that radioactive items destined for disposal at a radioactive waste burial facility near Beatty, Nevada had instead been distributed to wide segments of the public domain. Because the facility was jointly licensed by the State of Nevada and the Federal Nuclear Regulatory Commission, both agencies quickly responded. It was learned that over a period of several years a practice existed at the disposal facility of opening containers, removing contents and allowing employees to take items of worth or fancy. Numerous items such as hand tools, electric motors, laboratory instruments, shipping containers, etc., had received widespread and uncontrolled distribution in the town of Beatty as well as lesser distributions to other locations. Because the situation might have had the potential for a significant health and safety impact, a comprehensive recovery operation was conducted. During the course of seven days of intense effort, thirty-five individuals became involved in a comprehensive door by door survey and search of the town. Aerial surveys were performed using a helicopter equipped with sensitive radiation detectors, while ground level scans were conducted using a van containing similar instrumentation. Aerial reconnaissance photographs were taken, a special town meeting was held and numerous persons were interviewed. The recovery effort resulted in a retrieval of an estimated 20 to 25 pickup truck loads of radioactively contaminated equipment as well as several loads of large items returned on a 40-foot flatbed trailer

  17. Variations in water balance and recharge potential at three western desert sites

    International Nuclear Information System (INIS)

    Gee, G.W.; Fayer, M.J.; Rockhold, M.L.; Wierenga, P.J.; Young, M.H.; Andraski, B.J.

    1994-01-01

    Radioactive and hazardous waste landfills exist at numerous desert locations in the USA. At these locations, annual precipitation is low and soils are generally dry, yet little is known about recharge of water and transport of contaminants to the water table. Recent water balance measurements made at three desert locations, Las Cruces, NM, Beatty, NV, and the U.S. Department of Energy's Hanford Site in the state of Washington, provide information on recharge potential under three distinctly different climate and soil conditions. All three sites show water storage increases with time when soils are coarse textured and plants are removed from the surface, the rate of increase being influenced by climatic variables such as precipitation, radiation, temperature, and wind. Lysimeter data from Hanford and Las Cruces indicate that deep drainage (recharge) from bare, sandy soils can range from 10 to > 50% of the annual precipitation. At Hanford, when desert plants are present on sandy or gravelly surface soils, deep drainage is reduced but not eliminated. When surface soils are silt loams, deep drainage is eliminated whether plants are present or not. At Las Cruces and Beatty, the presence of plants eliminated deep drainage at the measurement sites. Differences in water balance between sites are attributed to precipitation quantity and distribution and to soil and vegetation types. The implication of waste management at desert locations is that surface soil properties and plant characteristics must be considered in waste site design in order to minimize recharge potential. 39 refs., 9 figs., 3 tabs

  18. Development of New Correlation and Assessment of Correlations for Two-Phase Pressure Drop in Rectangular Microchannels

    International Nuclear Information System (INIS)

    Choi, Chi Woong; Yu, Dong In; Kim, Moo Hwan

    2010-01-01

    There are two kinds of models in two-phase pressured drop; homogeneous flow model and separated flow model. Many previous researchers have developed correlations for two-phase pressure drop in a microchannel. Most correlations were modified Lockhart and Martinelli's correlation, which was based on the separated flow model. In this study, experiments for adiabatic liquid water and nitrogen gas flow in rectangular microchannels were conducted to investigate two-phase pressure drop in the rectangular microchannels. Two-phase frictional pressure drop in the rectangular microchannels is highly related with flow regime. Homogeneous model with six two-phase viscosity models: Owen(21)'s, MacAdams(22)'s, Cicchitti et al.(23)'s, Dukler et al.(24)'s, Beattie and Whalley(25)'s, Lin et al.(26)'s models and six separated flow models: Lockhart and Martinelli(27)'s, Chisholm(31)'s, Zhang et al.(15)'s, Lee and Lee(5)'s, Moriyama and Inue(4)'s, Qu and Mudawar(8)'s models were assessed with our experimental data. The best two-phase viscosity model is Beattie and Whalley's model. The best separated flow model is Qu and Mudawar's correlation. Flow regime dependency in both homogeneous and separated flow models was observed. Therefore, new flow pattern based correlations for both homogeneous and separated flow models were individually proposed

  19. Directions in low-level radioactive waste management. Low level-radioactive waste disposal: currently operating commercial facilities

    International Nuclear Information System (INIS)

    1983-09-01

    This publication discusses three commercial facilities that receive and dispose of low-level radioactive waste. The facilities are located in Barnwell, South Carolina; Beatty, Nevada; and Richland, Washington. All three facilities initiated operations in the 1960s. The three facilities have operated without such major problems as those which led to the closure of three other commercial disposal facilities located in the United States. The Beatty site could be closed in 1983 as a result of a Nevada Board of Health ruling that renewal of the site license would be inimical to public health and safety. The site remains open pending federal and state court hearings, which began in January 1983, to resolve the Board of Health ruling. The three sites may also be affected by NRC's 10 CFR Part 61 regulations, but the impact of those regulations, issued in December 1982, has not yet been assessed. This document provides detailed information on the history and current status of each facility. This information is intended, primarily, to assist state officials - executive, legislative, and agency - in planning for, establishing, and managing low-level waste disposal facilities. 12 references

  20. Characterization of organics in leachates from low-level radioactive waste disposal sites

    International Nuclear Information System (INIS)

    Francis, A.J.; Iden, C.R.; Nine, B.; Chang, C.

    1979-01-01

    Low-level radioactive wastes generated by the nuclear industry, universities, research institutions, and hospitals are disposed of in shallow-land trenches and pits. In 1962 the first commercial disposal site was opened in Beatty, Nevada. Since then, the industry has grown to include three private companies operating six disposal areas located in sparsely populated areas: at Maxey Flats (Morehead), Kentucky; Beatty, Nevada; Sheffield, Illinois; Barnwell, South Carolina; West Valley, New York; and Richland, Washington. Although the facilities are operated by private industry, they are located on public land and are subject to federal and state regulation. Although inventories of the radioactive materials buried in the disposal sites are available, no specific records are kept on the kinds and quantities of organic wastes buried. In general, the organic wastes consist of contaminated paper, packing materials, clothing, plastics, ion-exchange resins, scintillation vials, solvents, chemicals, decontamination fluids, carcasses of experimental animals, and solidification agents. Radionuclides such as 14 C, 3 H, 90 Sr, 134 137 Cs, 60 Co, 241 Am, and 238 239 240 Pu have been identified in leachate samples collected from several trenches at Maxey Flats and West Valley. The purpose of this report is to identify some of the organic compounds present in high concentrations in trench leachates at the disposal sites in order to begin to evaluate their effect on radionuclide mobilization and contamination of the environment

  1. Factors influencing choice of chemotherapy in metastatic colorectal cancer (mCRC

    Directory of Open Access Journals (Sweden)

    Rossi L

    2013-11-01

    Full Text Available Luigi Rossi, Foteini Vakiarou, Federica Zoratto, Loredana Bianchi, Anselmo Papa, Enrico Basso, Monica Verrico, Giuseppe Lo Russo, Salvatore Evangelista, Guilia Rinaldi, Francesca Perrone-Congedi, Gian Paolo Spinelli, Valeria Stati, Davide Caruso, Alessandra Prete, Silverio TomaoDepartment of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, ItalyAbstract: Management of metastatic colorectal cancer requires a multimodal approach and must be performed by an experienced, multidisciplinary expert team. The optimal choice of the individual treatment modality, according to disease localization and extent, tumor biology, and patient clinical characteristics, will be one that can maintain quality of life and long-term survival, and even cure selected patients. This review is an overview of the different therapeutic approaches available in metastatic colorectal cancer, for the purpose of defining personalized therapeutic algorithms according to tumor biology and patient clinical features.Keywords: metastatic colorectal cancer, patient clinical features, tumor biology, multidisciplinary approach

  2. Three-point functions in N=4 SYM: the hexagon proposal at three loops

    Energy Technology Data Exchange (ETDEWEB)

    Eden, Burkhard [Institut für Mathematik & Institut für Physik, Humboldt-Universität zu Berlin,Zum großen Windkanal 6, D-12489 Berlin (Germany); Sfondrini, Alessandro [Institut für Theoretische Physik, ETH Zürich,Wolfgang-Pauli-Str. 27, CH-8093 Zürich (Switzerland)

    2016-02-24

    Basso, Komatsu and Vieira recently proposed an all-loop framework for the computation of three-point functions of single-trace operators of N=4 super-Yang-Mills, the “hexagon program”. This proposal results in several remarkable predictions, including the three-point function of two protected operators with an unprotected one in the SU(2) and SL(2) sectors. Such predictions consist of an “asymptotic” part — similar in spirit to the asymptotic Bethe Ansatz of Beisert and Staudacher for two-point functions — as well as additional finite-size “wrapping” Lüscher-like corrections. The focus of this paper is on such wrapping corrections, which we compute at three-loops in the SL(2) sector. The resulting structure constants perfectly match the ones obtained in the literature from four-point correlators of protected operators.

  3. Interferenze sintattiche di origine romanza nelle parlate slovene occidentali: la strutturazione del sintagma aggettivale, della frase, del periodo

    Directory of Open Access Journals (Sweden)

    Mitja Skubic

    1991-12-01

    Full Text Available Il Festeggiato si è occupato, a più riprese, delle interferenze linguistiche tra il mondo slavo e quello romanzo; ha dedicato, e dedica tutt'ora, una buona parte dell'energia e dell'attività scientifica all'istroromanzo, il quale istroromanzo sta in opposizione diglossica, quale registra basso, rispetto al serbocroato, da una parte, e all'italiano, e magari alla koinè veneta, dall'altra. Il Tekavčić ci ha offerto delle analisi interessanti ed esaustive, delle quali ha beneficiato anche questa rivista, nel campo semantico e lessicale. Non ha trascurato nemmeno problemi concernenti le interferenze sintattiche, e questo fin dalle sue ricerche sulla parlata di Dignano. Il problema della consecutio temporum, ad esempio.

  4. Politica bancaria e sviluppo economico: rileggendo l'era menichelliana e quella attuale

    Directory of Open Access Journals (Sweden)

    Mario Sarcinelli

    2005-03-01

    Full Text Available Il basso tasso di crescita dell’Italia, anche nel contesto internazionale ed europeo, ha spinto a confrontare gli anni ’50 con gli ultimi dieci o quindici. Dall’analisi emerge che, se si esclude l’iniziale liberalizzazione del commercio internazionale, il periodo che vide la più vigorosa crescita dell’Italia fu caratterizzato dall’economia mista, da monopoli pubblici e posizioni private dominanti, da una politica monetaria e bancaria basata su controlli diretti ed esercizi di persuasione morale individuale, tutte condizioni oggi ritenute sfavorevoli alla crescita. Al contrario, nella fase attuale l’enfasi è stata sul modello di economia liberale, con liberalizzazioni, privatizzazioni di imprese produttive e di banche, politiche incentrate sugli incentivi e sul mercato. Purtroppo, la scienza economica non ha ancora trovato il paradigma generale che spiega la ricchezza delle nazioni a prescindere dal contesto e dagli uomini che lo animano.

  5. Il rumore elettrico Dalla fisica alla progettazione

    CERN Document Server

    Pallottino, Giovanni Vittorio

    2011-01-01

    L’opera fornisce una trattazione chiara, agile ed essenziale, ma completa, del rumore elettrico, argomento considerato generalmente oscuro e specialistico. Molto più breve (circa 275mila battute) dei testi attualmente disponibili. Il contenuto copre gli aspetti essenziali della matematica e della fisica del rumore (termico, shot. 1/f, …), e della sua rappresentazione nei circuiti. Discute quindi il rumore nei dispositivi passivi e attivi, e introduce i criteri di progettazione a basso rumore. Affronta infine brevemente questioni quali l’estrazione del segnale dal rumore e gli impieghi utili del rumore. L’attenzione è generalmente rivolta alla strumentazione fisica a bassa frequenza, in relazione alla pluridecennale esperienza specifica dell’autore. Si tratta di una estensione delle dispense, utilizzate per anni, di un corso universitario. Pertanto la trattazione è fortemente didattica, con particolare attenzione a rimuovere ambiguità e incertezze, discutendo il materiale in termini fisici intuit...

  6. The AMEBA PWR, a new concept in the technology of nuclear reactor safety

    Energy Technology Data Exchange (ETDEWEB)

    Novelli, A

    2000-05-01

    AMEBA is an Italian acronym which stands for 'alta moderazione e basso arricchimento' (high moderation and low enrichment). The AMEBA reactor is nothing more than a PWR which possesses very unusual values of both volumetric ratio moderator/fuel and U-235 enrichment of UO{sub 2}. The possibility is shown of the technical realisation of a nuclear power plant equipped with an AMEBA PWR reactor. Among the most enticing properties of AMEBA are the following: self-shut-down in any abnormal condition, elimination of all need for control rods and boric acid dissolution in the water, absolute impossibility of reaching values of reactivity greater than a fraction of a dollar, intrinsic subcriticality, attaining to several dollars, in non-operative condition when the water is at ambient temperature, normal operation with a very small-sized pressurizer, self-start-up.

  7. The AMEBA PWR, a new concept in the technology of nuclear reactor safety

    International Nuclear Information System (INIS)

    Novelli, A.

    2000-01-01

    AMEBA is an Italian acronym which stands for 'alta moderazione e basso arricchimento' (high moderation and low enrichment). The AMEBA reactor is nothing more than a PWR which possesses very unusual values of both volumetric ratio moderator/fuel and U-235 enrichment of UO 2 . The possibility is shown of the technical realisation of a nuclear power plant equipped with an AMEBA PWR reactor. Among the most enticing properties of AMEBA are the following: self-shut-down in any abnormal condition, elimination of all need for control rods and boric acid dissolution in the water, absolute impossibility of reaching values of reactivity greater than a fraction of a dollar, intrinsic subcriticality, attaining to several dollars, in non-operative condition when the water is at ambient temperature, normal operation with a very small-sized pressurizer, self-start-up

  8. Regge meets collinear in strongly-coupled N=4 super Yang-Mills

    Energy Technology Data Exchange (ETDEWEB)

    Sprenger, Martin [Institut für Theoretische Physik, Eidgenössische Technische Hochschule Zürich,Wolfgang-Pauli-Strasse 27, 8093 Zürich (Switzerland)

    2017-01-10

    We revisit the calculation of the six-gluon remainder function in planar N=4 super Yang-Mills theory from the strong coupling TBA in the multi-Regge limit and identify an infinite set of kinematically subleading terms. These new terms can be compared to the strong coupling limit of the finite-coupling expressions for the impact factor and the BFKL eigenvalue proposed by Basso et al. in https://www.doi.org/10.1007/JHEP01(2015)027, which were obtained from an analytic continuation of the Wilson loop OPE. After comparing the results order by order in those subleading terms, we show that it is possible to precisely map both formalisms onto each other. A similar calculation can be carried out for the seven-gluon amplitude, the result of which shows that the central emission vertex does not become trivial at strong coupling.

  9. Sviluppi di Ricevitori E di Componentistica Per Banda 3 mm Ad INAF-OA Cagliari

    Science.gov (United States)

    Navarrini, Alessandro

    2017-11-01

    L'INAF-OA Cagliari (OACa) sta sviluppando un ricevitore criogenico a basso rumore basato su un mixer SSB (Single Side Band) a superconduttore SIS (Superconductor-Insulator-Superconductor) per la banda 3 mm. Il ricevitore, acquistato da IRAM, è stato fortemente modificato per essere adattato al fuoco Gregoriano di SRT (Sardinia Radio Telescope). Lo strumento è caratterizzato da una nuova criogenia a ciclo chiuso 4 K (per evitare l'uso di elio liquido in antenna), da un nuovo oscillatore locale (di tipo ALMA Banda 3) e da un nuovo sistema di controllo e di monitoraggio basato su schede Raspberry ed Arduino sviluppato ad OACa. Verranno presentati i recenti sviluppi sul ricevitore, inclusi i risultati preliminari della misura della temperatura di rumore, che raggiunge un valore pari a Trec=66 K alla frequenza di 86 GHz, nonostante la criogenia non sia ancora ottimizzata. L'INAF-OACa è coinvolto nel progetto AETHRA (Advanced European Technologies for Heterodyne Receivers for Astronomy) nel quadro del programma Radionet/Horizon2020 per il quale sta contribuendo al WP1 (Work Package 1). Lo scopo del WP1 è di sviluppare e costruire un dimostratore di un array di ricevitori a doppia polarizzazione per la banda 3 mm basato su amplificatori criogenici a basso rumore (LNA) in tecnologia a semiconduttore MMIC. Nell'ambito del WP1 l'OACa ha in carico il progetto di un OrthomodeTransducer (OMT) in guida d'onda o in tecnologia planare per la banda 72-116 GHz che sia integrabile con amplificatori MMICs ed adatto all'integrazione in un array da installare nel piano focale di un radiotelescopio. Verranno presentati i design preliminari degli OMT per AETHRA, che sono basati su prototipi sviluppati in passato da OACa.

  10. Las especies de Trichogramma de Uruguay (Hymenoptera: Trichogrammatidae Trichogramma species from Uruguay (Hymenoptera: Trichogrammatidae

    Directory of Open Access Journals (Sweden)

    César Basso

    2004-07-01

    Full Text Available Fueron recolectadas cinco especies de Trichogramma Westwood en Uruguay. La más ampliamente distribuida T. pretiosum Riley parasita Diatraea saccharalis (Fabricius, Heliothis zea (Boddie, Alabama argillacea (Hübner y Argyrotaenia sphaleropa (Meyrick. Trichogramma exiguum Pinto & Platner, a menudo confundida con T. fuentesi Torre, parasitan Bonagota cranaodes (Meyrick y A. sphaleropa. Otras dos especies T. galloi Zucchi y T. distinctum Zucchi parasita D. saccharalis. Ellas presentan una morfología relativamente similar y, de acuerdo a la información disponible, no es posible decidir si son especies próximas o sinónimas. Finalmente, T. bellaunionense Basso & Pintureau fue recolectada en Uruguay hasta el momento sólo sobre D. saccharalis. Se provee una clave ilustrada para determinar esas cinco especies. Por otra parte, se incluye una revisión del uso actual y proyectado de Trichogramma para controlar diferentes plagas en diversos cultivos en este país.Five Trichogramma Westwood species were collected in Uruguay. The widely distributed T. pretiosum Riley parasitizes Diatraea saccharalis (Fabricius, Heliothis zea (Boddie, Alabama argillacea (Hübner and Argyrotaenia sphaleropa (Meyrick. Trichogramma exiguum Pinto & Platner, often confused with T. fuentesi Torre, parasitizes Bonagota cranaodes (Meyrick and A. sphaleropa. The two species T. galloi Zucchi and T. distinctum Zucchi parasitize D. saccharalis. Their morphology is relatively close and, from the information available, it is not possible to decide if they are closely related species or synonymous species. Finally, up to now, T. bellaunionense Basso & Pintureau was only collected from Uruguay on D. saccharalis. An illustrated key is provided to identify these five species. Moreover, the present and expected use of Trichogramma to control different pests in different Uruguayan crops is reviewed.

  11. Topic I: Induced changes in hydrology at low-level radioactive waste repository sites: A section in Safe disposal of radionuclides in low-level radioactive-waste repository sites; Low-level radioactive-waste disposal workshop, U.S. Geological Survey, July 11-16, 1987, Big Bear Lake, Calif., Proceedings (Circular 1036)

    Science.gov (United States)

    Prudic, David E.; Dennehy, Kevin F.; Bedinger, Marion S.; Stevens, Peter R.

    1990-01-01

    Engineering practices, including the excavation of trenches, placement of waste, nature of waste forms, backfilling procedures and materials, and trench-cover construction and materials at low-level radioactive-waste repository sites greatly affect the geohydrology of the sites. Engineering practices are dominant factors in eventual stability and isolation of the waste. The papers presented relating to Topic I were discussions of the hydrogeologic setting at existing low-level radioactive-waste repository sites and changes in the hydrology induced by site operations. Papers summarizing detailed studies presented at this workshop include those at sites near Sheffield, Ill.; Oak Ridge National Laboratory, Tenn.; West Valley, N.Y.; Maxey Flats, Ky.; Barnwell, S.C.; and Beatty, Nev. 

  12. Operation BUSTER. Project 8.2. Air Weather Service Participation in Operation BUSTER

    Science.gov (United States)

    1951-12-31

    Nearest precipitation, acattered ahoware 55u milea to Northeast* HnOHT OROöND ZEROt U, l53 »li ft MSL. HEIQHT OP BÜRSTi 5,311«U ft MSL FRESSÖRE...17 270 27 63 MERCURY WEATHER STATION AEC TEST SITE US VEGAS, N’EVADA •*IND DATA SHEET PATE 22 Octob«r 1951 BEATTY, NEVADA TD /E 220e Z...WIND DATA SHEET TOROPAH, HET/ADA TD - ^ 0300 Z 330P 3£HäE (knots) 15 350 16 010 15 030 13 130 12 050 16 050 29 050 31 060 30 060 30 070 37

  13. LLW Notes, Volume 12, Number 5

    International Nuclear Information System (INIS)

    Norris, C.; Brown, H.; Gedden, R.; Lovinger, T.; Scheele, L.; Shaker, M.A.

    1997-06-01

    Contents include articles entitled: USGS report supports previous conclusions re tritium migration at Beatty; Ohio selects new contractor for screening; Maine Yankee's future uncertain; Southeast Compact limits funds for North Carolina project; California, Energy, and Interior exchange correspondence on Ward Valley testing; TCC meets in Salt Lake City, Utah; Garner named executive director and forum participant for Northwest Compact; Seventh Circuit upholds Energy Secretary's determination re distribution of surcharge rebates; US Ecology sues Nebraska re wetlands mitigation; US Supreme Court hears line-item veto challenge; Court rules NAS must provide public access; WCS sues Envirocare of Texas; DOE and Envirocare sign consent agreement; NRC issues performance assessment guidance; NRC to publish final decommissioning rule; House subcommittee passes Texas Consent Act; Environmental justice bill introduced in the House; and International nuclear safety body established

  14. Demographic survey centered around the Nevada Test Site, Nye County, Nevada

    International Nuclear Information System (INIS)

    Richard-Haggard, K.

    1983-03-01

    Demographic data were gathered for several small population centers on and around the Nevada Test Site (NTS). Population projections were made for the three townships that include most of the major population centers in the study area, based on the share approach. These townships were Alamo Township (Lincoln County), Beatty and Pahrump townships (Nye County). It was estimated that the total population of these three townships, plus Clark County, would reach a maximum of 934,000 people by the year 2000. It was assumed that the on-site population of the NTS would continue to be a function of activity at the site, and that this would, if anything, aid in the attainment of site objectives

  15. Mechanistic model of the inverted annular film boiling

    International Nuclear Information System (INIS)

    Seok, Ho; Chang, Soon Heung

    1989-01-01

    An analytical model is developed to predict the heat transfer coefficient and the friction factor in the inverted annular film boiling. The developed model is based on two-fluid mass, momentum and energy balance equations and a theoretical velocity profile. The predictions of the proposed model are compared with the experimental data and the well-established correlations. For the heat transfer coefficient, they agree with the experimental data and are more promising than those of Bromely and Berenson correlations. The present model also accounts the effects of the mass flux and subcooling on the heat transfer. The friction factor predictions agree qualitatively with the experimental measurements, while some cases show a similar behavior with those of the post-CHF dispersed flow obtained from Beattie's correlation

  16. Air Quality Scoping Study for Ash Meadows National Wildlife Refuge, Nevada (EMSI April 2007)

    Energy Technology Data Exchange (ETDEWEB)

    Engelbrecht, Johann; Kavouras, Ilias; Campbell, Dave; Campbell, Scott; Kohl, Steven; Shafer, David

    2007-04-01

    The Desert Research Institute (DRI) is performing a scoping study as part of the U.S.Department of Energy’s Yucca Mountain Environmental Monitoring Systems Initiative (EMSI). The main objective is to obtain baseline air quality information for Yucca Mountain and an area surrounding the Nevada Test Site (NTS). Air quality and meteorological monitoring and sampling equipment housed in a mobile trailer (shelter) is collecting data at seven sites outside the NTS, including Ash Meadows National Wildlife Refuge, Sarcobatus Flat, Beatty, Rachel, Caliente, Pahranagat National Wildlife Refuge, and Crater Flat, and at four sites on the NTS. The trailer is stationed at any one site for approximately eight weeks at a time. Letter reports provide summaries of air quality and meteorological data, on completion of each site’s sampling program.

  17. Disposal of low-level and mixed low-level radioactive waste during 1990

    International Nuclear Information System (INIS)

    1993-08-01

    Isotopic inventories and other data are presented for low-level radioactive waste (LLW) and mixed LLW disposed (and occasionally stored) during calendar year 1990 at commercial disposal facilities and Department of Energy (DOE) sites. Detailed isotopic information is presented for the three commercial disposal facilities located near Barnwell, SC, Richland, WA, and Beatty, NV. Less information is presented for the Envirocare disposal facility located near Clive, UT, and for LLW stored during 1990 at the West Valley site. DOE disposal information is included for the Savannah River Site (including the saltstone facility), Nevada Test Site, Los Alamos National Laboratory, Idaho National Engineering Laboratory, Hanford Site, Y-12 Site, and Oak Ridge National Laboratory. Summary information is presented about stored DOE LLW. Suggestions are made about improving LLW disposal data

  18. Dynamic behaviour of the contact line for 350 km/h on the new line Wuhan - Guangzhou; Dynamisches Verhalten der Oberleitung fuer 350 km/h auf der neuen Strecke Wuhan - Guangzhou

    Energy Technology Data Exchange (ETDEWEB)

    Zimmert, Gerhard [Balfour Beatty Rail, Beijing (China)

    2010-04-15

    Only after four and a half years of construction activities regular services started on the approximately 1 000 km long new high-speed line Wuhan - Guangzhou in the People's Republic of China. Achieving 320 to 330 km/h commercial speed, this line is the fastest railway connection in the world. The dynamic interaction between contact line and pantograph determines the maximally possible speed to an increasing extent. Worldwide, there is only low experience on the contact line dynamic behavior at this speed level. Balfour Beatty Rail designed the contact line for this installation, participated essentially in the implementation and, therefore, was in charge of proving the contact line quality. A series of test runs concerning the geometrical requirements and the contact force behaviour eventually proved the suitability of the system. (orig.)

  19. Ground-water altitudes and well data, Nye County, Nevada, and Inyo County, California

    International Nuclear Information System (INIS)

    Ciesnik, M.S.

    1995-01-01

    This report contains ground-water altitudes and well data for wells located in Nye County, Nevada, and Inyo County, California, south of Yucca Mountain, Nevada, the potential site for a high-level nuclear waste repository. Data are from wells whose coordinates are within the Beatty and Death Valley Junction, California-Nevada maps from the US Geological Survey, scale 1:100,000 (30-minute x 60-minute quadrangle). Compilation of these data was made to provide a reference for numerical models of ground-water flow at Yucca Mountain and its vicinity. Water-level measurements were obtained from the US Geological Survey National Water Information System (NWIS) data base, and span the period of October 1951 to May 1991; most measurements were made from 1980 to 1990

  20. Environmental monitoring report for commercial low-level radioactive waste disposal sites (1960's through 1990's)

    International Nuclear Information System (INIS)

    1996-11-01

    During the time period covered in this report (1960's through early 1990's), six commercial low-level radioactive waste (LLRW) disposal facilities have been operated in the US. This report provides environmental monitoring data collected at each site. The report summarizes: (1) each site's general design, (2) each site's inventory, (3) the environmental monitoring program for each site and the data obtained as the program has evolved, and (4) what the program has indicated about releases to off-site areas, if any, including a statement of the actual health and safety significance of any release. A summary with conclusions is provided at the end of each site's chapter. The six commercial LLRW disposal sites discussed are located near: Sheffield, Illinois; Maxey Flats, Kentucky; Beatty, Nevada; West Valley, New York; Barnwell, South Carolina; Richland, Washington

  1. Combining Human Resource and Stakeholder Management Perspectives

    DEFF Research Database (Denmark)

    Ravazzani, Silvia; Mormino, Sara

    2015-01-01

    This paper explores collaborative learning activities involving HR and external stakeholders that organizations decide to plan and implement in order to obtain benefits in terms of knowledge sharing, stakeholder understanding and value creation. The increasing uncertainty and multiplicity of comp...... and corporate learning in a stakeholder-oriented perspective can play a strategic role in supporting business strategy, providing organizations the resources to meet internal and external needs (Wilson, 2005) and to interconnect with their value network.......This paper explores collaborative learning activities involving HR and external stakeholders that organizations decide to plan and implement in order to obtain benefits in terms of knowledge sharing, stakeholder understanding and value creation. The increasing uncertainty and multiplicity...... of competitive pressures and stakeholder demands (Harrison, St. John, 1996) require organizations, and in particular HR, to take on a more strategic role aimed to build new capability and support the overarching business strategy (Ulrich, Beatty 2001). This study draws on Strategic Human Resource Management...

  2. Native Americans and Yucca Mountain: A revised and updated summary report on research undertaken between 1987 and 1991

    International Nuclear Information System (INIS)

    Fowler, C.S.

    1991-01-01

    This report summarizes data collected between September 1986 and September 1988 relative to Native American concerns involving the potential siting of a high-level nuclear waste repository at Yucca Mountain, Nevada. The data were collected from Western Shoshone and Southern Paiute people upon whose aboriginal lands the repository potentially is to be located. Western Shoshone people involved in the study were those resident or affiliated with reservation communities at Yomba and Duckwater, Nevada, and Death Valley, California. Southern Paiute people were at reservation communities at Moapa and Las Vegas. Additional persons of Western Shoshone and Southern Paiute descent were interviewed at Beatty, Tonopah, Caliente, Pahrump, and Las Vegas, Nevada. The work was part of a larger project of socioeconomic studies for the State of Nevada's Nuclear Waste Projects office, conducted by Mountain West of Phoenix, Arizona

  3. LLW Notes, Volume 12, Number 5

    Energy Technology Data Exchange (ETDEWEB)

    Norris, C.; Brown, H. [eds.; Gedden, R.; Lovinger, T.; Scheele, L.; Shaker, M.A.

    1997-06-01

    Contents include articles entitled: USGS report supports previous conclusions re tritium migration at Beatty; Ohio selects new contractor for screening; Maine Yankee`s future uncertain; Southeast Compact limits funds for North Carolina project; California, Energy, and Interior exchange correspondence on Ward Valley testing; TCC meets in Salt Lake City, Utah; Garner named executive director and forum participant for Northwest Compact; Seventh Circuit upholds Energy Secretary`s determination re distribution of surcharge rebates; US Ecology sues Nebraska re wetlands mitigation; US Supreme Court hears line-item veto challenge; Court rules NAS must provide public access; WCS sues Envirocare of Texas; DOE and Envirocare sign consent agreement; NRC issues performance assessment guidance; NRC to publish final decommissioning rule; House subcommittee passes Texas Consent Act; Environmental justice bill introduced in the House; and International nuclear safety body established.

  4. Shipment of LLW by intercoastal maritime service

    International Nuclear Information System (INIS)

    Barbour, D.A.

    1985-01-01

    Transportation costs are a significant element of total waste disposal costs. In 1982, Nuclear Metals, Inc. (NMI) began a series of tests and investigations to examine the feasibility of using alternative modes for its low-level waste (LLW) shipments. NMI's investigations and experience have identified significant problems in transporting LLW by rail. Intercoastal maritime service, however, has been demonstrated as a safe and cost-effective way of transporting LLW from eastern seaboard generation sites to the repository at Beatty, Nevada. Intuition is an unreliable guide in this area. Waste managers need to periodically assess and compare combined transportation and burial costs for all site options to ensure that disposal operations are conducted in the most rational way

  5. Letter Report Yucca Mountain Environmental Monitoring Systems Initiative - Air Quality Scoping Study for Pahranagat National Wildlife Refuge, Lincoln County, Nevada

    International Nuclear Information System (INIS)

    Engelbrecht, J.; Kavouras, I.; Campbell, D.; Campbell, S.; Kohl, S.; Shafer, D.

    2009-01-01

    The Desert Research Institute (DRI) is performing a scoping study as part of the U.S. Department of Energy's Yucca Mountain Environmental Monitoring Systems Initiative (EMSI). The main objective is to obtain baseline air quality information for Yucca Mountain and an area surrounding the Nevada Test Site (NTS). Air quality and meteorological monitoring and sampling equipment housed in a mobile trailer (shelter) is collecting data at eight sites outside the NTS, including Ash Meadows National Wildlife Refuge (NWR), Pahranagat NWR, Beatty, Rachel, Caliente, Crater Flat, and Tonopah Airport, and at four sites on the NTS (Engelbrecht et al., 2007a-d). The trailer is stationed at any one site for approximately eight weeks at a time. This letter report provides a summary of air quality and meteorological data on completion of the site's sampling program

  6. Letter Report Yucca Mountain Environmental Monitoring Systems Initiative - Air Quality Scoping Study for Tonopah Airport, Nye County, Nevada

    International Nuclear Information System (INIS)

    Engelbrecht, J.; Kavouras, I.; Campbell, D.; Campbell, S.; Kohl, S.; Shafer, D.

    2009-01-01

    The Desert Research Institute (DRI) is performing a scoping study as part of the U.S. Department of Energy's Yucca Mountain Environmental Monitoring Systems Initiative (EMSI). The main objective is to obtain baseline air quality information for Yucca Mountain and an area surrounding the Nevada Test Site (NTS). Air quality and meteorological monitoring and sampling equipment housed in a mobile trailer (shelter) is collecting data at eight sites outside the NTS, including Ash Meadows National Wildlife Refuge (NWR), Tonopah Airport, Beatty, Rachel, Caliente, Pahranagat NWR, Crater Flat, and the Tonopah Airport, and at four sites on the NTS (Engelbrecht et al., 2007a-d). The trailer is stationed at any one site for approximately eight weeks at a time. This letter report provides a summary of air quality and meteorological data, on completion of the site's sampling program

  7. Letter Report Yucca Mountain Environmental Monitoring Systems Initiative - Air Quality Scoping Study for Caliente, Lincoln County, Nevada

    International Nuclear Information System (INIS)

    Engelbrecht, J.; Kavouras, I.; Campbell, D.; Campbell, S.; Kohl, S.; Shafer, D.

    2009-01-01

    The Desert Research Institute (DRI) is performing a scoping study as part of the U.S. Department of Energy's Yucca Mountain Environmental Monitoring Systems Initiative (EMSI). The main objective is to obtain baseline air quality information for Yucca Mountain and an area surrounding the Nevada Test Site (NTS). Air quality and meteorological monitoring and sampling equipment housed in a mobile trailer (shelter) is collecting data at eight sites outside the NTS, including Ash Meadows National Wildlife Refuge (NWR), Beatty, Sarcobatus Flats, Rachel, Caliente, Pahranagat NWR, Crater Flat, and Tonopah Airport, and at four sites on the NTS (Engelbrecht et al., 2007a-d). The trailer is stationed at any one site for approximately eight weeks at a time. This letter report provides a summary of air quality and meteorological data, on completion of the site's sampling program

  8. US ecology data system

    International Nuclear Information System (INIS)

    Crase, A.

    1987-01-01

    The US Ecology computer data system was instituted March 1, 1982. This system was designed to manage the increasing flow of paperwork and data associated with the receipt and disposal of low-level radioactive waste at Richland, Washington and Beatty, Nevada. The system was modified and upgraded in 1984 to accommodate a revised shipping manifest pursuant to the requirements of 10 CFR 20.311. The data system is used to generate various reports for both internal and external distribution. The computer system is located at US Ecology's corporate headquarters in Louisville, Kentucky. Remote access terminals are located at the disposal sites. The system is supported by a Wang VS-100 processor. In addition to supporting the radwaste data system, the system supports a chemical waste data base, word processing, and electronic mail. The management and operation of this data base are described. 19 figures

  9. Native Americans and Yucca Mountain: A revised and updated summary report on research undertaken between 1987 and 1991; Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Fowler, C.S. [Cultural Resources Consultants Ltd., Reno, NV (United States)

    1991-10-15

    This report summarizes data collected between September 1986 and September 1988 relative to Native American concerns involving the potential siting of a high-level nuclear waste repository at Yucca Mountain, Nevada. The data were collected from Western Shoshone and Southern Paiute people upon whose aboriginal lands the repository potentially is to be located. Western Shoshone people involved in the study were those resident or affiliated with reservation communities at Yomba and Duckwater, Nevada, and Death Valley, California. Southern Paiute people were at reservation communities at Moapa and Las Vegas. Additional persons of Western Shoshone and Southern Paiute descent were interviewed at Beatty, Tonopah, Caliente, Pahrump, and Las Vegas, Nevada. The work was part of a larger project of socioeconomic studies for the State of Nevada`s Nuclear Waste Projects office, conducted by Mountain West of Phoenix, Arizona.

  10. Native Americans and Yucca Mountain: A revised and updated summary report on research undertaken between 1987 and 1991; Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Fowler, C.S. [Cultural Resources Consultants Ltd., Reno, NV (United States)

    1991-10-15

    This report consists of Yucca Mountain Project bibliographies. It is the appendix to a report that summarizes data collected between September 1986 and September 1988 relative to Native American concerns involving the potential siting of a high-level nuclear waste repository at Yucca Mountain, Nevada. The data were collected from Western Shoshone and Southern Paiute people upon whose aboriginal lands the repository potentially is to be located. Western Shoshone people involved in the study were those resident or affiliated with reservation communities at Yomba and Duckwater, Nevada, and Death Valley, California. Southern Paiute people were at reservation communities at Moapa and Las Vegas. Additional persons of Western Shoshone and Southern Paiute descent were interviewed at Beatty, Tonopah, Caliente, Pahrump, and Las Vegas, Nevada. The work was part of a larger project of socioeconomic studies for the State of Nevada`s Nuclear Waste Projects office, conducted by Mountain West of Phoenix, Arizona.

  11. Applications of the Basic programming language in X-ray spectrometry

    International Nuclear Information System (INIS)

    Diaz-Guerra, J.P.; Roca, M.

    1981-01-01

    An assembly of programs written in ''Basic'' language and related with the calculation needs at the X-ray spectrometry laboratory of the Spanish J.E.N. has been developed. The principal problems considered, concerning the X-ray fluorescence technique, are the following: selection of the instrumental parameters; correction of the effects due to the dead time, background and spectral interferences; fitting of polynomial functions, which relate the variables intensity-concentration; application of some empirical-mathematical methods (Lucas-Tooth, Beattie and Brissey and Tertian procedures) to the correction of the inter-element effects; addition method, and statistical treatment of the results (correlation coefficient and ''F'' and ''t'' tests). Likewise, programs for the computation of spacings from powder diffraction patterns (Debye-Scherrer and counter diffractometer procedures) have been written. The proposed programs run following conversational patterns, in which different possibilities and incidences have been foreseen. (author)

  12. Environmental monitoring report for commercial low-level radioactive waste disposal sites (1960`s through 1990`s)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    During the time period covered in this report (1960`s through early 1990`s), six commercial low-level radioactive waste (LLRW) disposal facilities have been operated in the US. This report provides environmental monitoring data collected at each site. The report summarizes: (1) each site`s general design, (2) each site`s inventory, (3) the environmental monitoring program for each site and the data obtained as the program has evolved, and (4) what the program has indicated about releases to off-site areas, if any, including a statement of the actual health and safety significance of any release. A summary with conclusions is provided at the end of each site`s chapter. The six commercial LLRW disposal sites discussed are located near: Sheffield, Illinois; Maxey Flats, Kentucky; Beatty, Nevada; West Valley, New York; Barnwell, South Carolina; Richland, Washington.

  13. Switch for Good Community Program

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, Tabitha [Balfour Beatty Military Housing Management LLC, Newtown Square, PA (United States); Amran, Martha [WattzOn, Inc., Mountain View, CA (United States)

    2013-11-19

    Switch4Good is an energy-savings program that helps residents reduce consumption from behavior changes; it was co-developed by Balfour Beatty Military Housing Management (BB) and WattzOn in Phase I of this grant. The program was offered at 11 Navy bases. Three customer engagement strategies were evaluated, and it was found that Digital Nudges (a combination of monthly consumption statements with frequent messaging via text or email) was most cost-effective. The program was delivered on-time and on-budget, and its success is based on the teamwork of local BB staff and the WattzOn team. The following graphic shows Switch4Good “by the numbers”, e.g. the scale of operations achieved during Phase I.

  14. Native Americans and Yucca Mountain: A revised and updated summary report on research undertaken between 1987 and 1991

    International Nuclear Information System (INIS)

    Fowler, C.S.

    1991-01-01

    This report consists of Yucca Mountain Project bibliographies. It is the appendix to a report that summarizes data collected between September 1986 and September 1988 relative to Native American concerns involving the potential siting of a high-level nuclear waste repository at Yucca Mountain, Nevada. The data were collected from Western Shoshone and Southern Paiute people upon whose aboriginal lands the repository potentially is to be located. Western Shoshone people involved in the study were those resident or affiliated with reservation communities at Yomba and Duckwater, Nevada, and Death Valley, California. Southern Paiute people were at reservation communities at Moapa and Las Vegas. Additional persons of Western Shoshone and Southern Paiute descent were interviewed at Beatty, Tonopah, Caliente, Pahrump, and Las Vegas, Nevada. The work was part of a larger project of socioeconomic studies for the State of Nevada's Nuclear Waste Projects office, conducted by Mountain West of Phoenix, Arizona

  15. The New Solar System

    Science.gov (United States)

    Beatty, J. Kelly; Collins Petersen, Carolyn; Chaikin, Andrew

    1999-01-01

    As the definitive guide for the armchair astronomer, The New Solar System has established itself as the leading book on planetary science and solar system studies. Incorporating the latest knowledge of the solar system, a distinguished team of researchers, many of them Principal Investigators on NASA missions, explain the solar system with expert ease. The completely-revised text includes the most recent findings on asteroids, comets, the Sun, and our neighboring planets. The book examines the latest research and thinking about the solar system; looks at how the Sun and planets formed; and discusses our search for other planetary systems and the search for life in the solar system. In full-color and heavily-illustrated, the book contains more than 500 photographs, portrayals, and diagrams. An extensive set of tables with the latest characteristics of the planets, their moon and ring systems, comets, asteroids, meteorites, and interplanetary space missions complete the text. New to this edition are descriptions of collisions in the solar system, full scientific results from Galileo's mission to Jupiter and its moons, and the Mars Pathfinder mission. For the curious observer as well as the student of planetary science, this book will be an important library acquisition. J. Kelly Beatty is the senior editor of Sky & Telescope, where for more than twenty years he has reported the latest in planetary science. A renowned science writer, he was among the first journalists to gain access to the Soviet space program. Asteroid 2925 Beatty was named on the occasion of his marriage in 1983. Carolyn Collins Petersen is an award-winning science writer and co-author of Hubble Vision (Cambridge 1995). She has also written planetarium programs seen at hundreds of facilities around the world. Andrew L. Chaikin is a Boston-based science writer. He served as a research geologist at the Smithsonian Institution's Center for Earth and Planetary Studies. He is a contributing editor to

  16. Poder de mercado no segmento de distribuição de gasolina C: uma análise a partir da Nova Organização Industrial Empírica

    Directory of Open Access Journals (Sweden)

    Rosangela Aparecida Soares Fernandes

    2013-09-01

    Full Text Available Este artigo tem como objetivo avaliar o grau de poder de mercado no setor de distribuição de gasolina C, nas regiões brasileiras, no período de 2002 a 2008. Para tal, baseou-se na Teoria da Nova Organização Industrial Empírica (NOIE, especificamente, no modelo proposto por Bresnahan (1982 e Lau (1982. Uma versão dinâmica do modelo também foi estimada. Os resultados indicaram que, exceto para a região Norte, para o modelo estático, as empresas distribuidoras de gasolina C não agem como tomadoras de preços (Λ = 0. No outro extremo, a hipótese de conluio perfeito (Λ = 1 entre elas foi rejeitada. Verificou-se que, em várias regiões, os parâmetros revelaram-se suficientemente baixos, sugerindo que as empresas distribuidoras apresentam elevada competição entre si.

  17. Site fidelity of male roe deer in a Mediterranean fragmented area

    Directory of Open Access Journals (Sweden)

    Claudia Melis

    2004-06-01

    "basso rischio e basso guadagno", volta a ottimizzare la sopravvivenza e la durata della vita riproduttiva.

  18. Verifica dell'appropriatezza dei ricoveri chirurgici secondo lo strumento RL-PVACE: valutazione economica e organizzativa nell'Azienda Ospedaliera G. Salvini

    Directory of Open Access Journals (Sweden)

    R. Barni

    2003-05-01

    Full Text Available

    Obiettivi: analizzare con lo strumento RL-PVACE l’appropriatezza dei ricoveri ordinari esitati in DRG chirurgici ad alto rischio di inappropriatezza; individuare e valutare economicamente i cambiamenti organizzativi necessari per raggiungere il livello di appropriatezza della circolare regionale 39/SAN.

    Metodi: il disegno dello studio è longitudinale e retrospettivo. È stata analizzata la sola giornata di ammissione di tutti i casi ordinari dimessi nel primo semestre dell’anno 2001, con esclusione dei casi 0- 1 giorno, ed esitati in DRG chirurgici che presentavano una quota di ricoveri ordinari, valutabili con RLPVA, superiore alla soglia di ammissibilità definita nel ddg n° 20180 (2002. I DRG così selezionati sono stati in ordine decrescente di numerosità: 119, 162, 55, 158, 222, 160, 267, 232, 270, 262, 40. Utilizzando i dati della contabilità analitica e ipotizzando lo spostamento in 1^ giornata o in day hospital dei ricoveri ordinari, è stato calcolato il punto di pareggio mediante la break-even analysis.

    Risultati: i dati presentati sono relativi a 845 cartelle cliniche corrispondenti ai DRG selezionati nei Presidi di Garbagnate e Bollate. È stato rilevato un livello assistenziale appropriato nel 38,3% dei casi mentre solo il 3,8% delle ammissioni si è rilevata tempestiva (appropriatezza complessiva 40,9%. Il criterio più adottato per l’attribuzione dell’appropriatezza del livello assistenziale è stato K3 (58,3%, seguito da L4 (20%, K1 (7%; meno frequenti i criteri J6 (3,4%, L3 (3,4%, J6 (3,4%, J4 (2,8%. Gli override sono stati attivati in una quota minoritaria di casi (2,1%. Dal punto di vista economico risulta relativamente conveniente il ricorso alla modalità del “one day surgery”.

    Conclusioni: l’utilizzo del protocollo RL-PVACE è risultato agevole (basso ricorso agli override. Il livello di appropriatezza raggiunto è in

  19. Tassi di cambio fluttuanti, deprezzamento valutario e domanda effettiva (Floating exchange rates, currency depreciation and actual demand

    Directory of Open Access Journals (Sweden)

    Julio López

    2012-04-01

    Full Text Available Il presente articolo esamina i vantaggi relativi dei tassi di cambio fluttuanti nei confronti di un regime di tassi di cambio a parità rigidamente ancorate (hard peg, ponendo particolare enfasi sulle implicazioni per la domanda effettiva. In particolare, esso valuta se un deprezzamento della valuta abbia un effetto benefico sulla domanda aggregata e dunque sull’occupazione. Si sostiene che tale questione è centrale per il principio della domanda effettiva, e che l’idea che un deprezzamento valutario sia in grado di stabilizzare la domanda effettiva, equivale in larga misura a sostenere che la flessibilità (verso il basso dei salari nominali (e reali possa assicurare la piena occupazione. Coerentemente con ciò, viene analizzata la relazione tra la flessibilità verso il basso dei salari e la domanda effettiva, e viene valutata criticamente (dal punto di vista sia teorico sia empirico l’ipotesi che la flessibilità del tasso di cambio possa avere proprietà stabilizzanti quando si tenga conto di shock esogeni di varia natura. L’articolo si chiude con brevi deduzioni di teoria e di politica economiche.   This paper examines the relative advantages of floating exchange rates against a system of exchange rates for the same rigidly anchored (hard peg, with particular emphasis on the implications for effective demand. In particular, it will assess whether a currency depreciation has a beneficial effect on aggregate demand and hence employment. It is argued that this issue is central to the principle of effective demand, and that the idea that a currency depreciation is able to stabilize the effective demand, is equivalent to a large extent to support that flexibility (down in nominal wages (and real to ensure full employment. Consistent with this, we analyze the relationship between the downward flexibility of wages and effective demand, and is critically evaluated (in terms of both theoretical and empirical hypothesis that the flexibility

  20. Research in radiobiology

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1959-10-15

    radiation response of simpler organisms. It has been observed that there are tremendous variations in the radiosensitivity of different organisms. A contract has been placed with the Chester Beatty Research Institute in London for research on the reasons for the variations in the radiosensitivity of different micro-organisms. One of the objects of the research being carried out at the Chester Beatty Institute is to examine how micro-organisms can be made more sensitive to radiation than they normally are

  1. Testing the Formation Pathway of a Transiting Brown Dwarf in a Middle-aged Cluster

    Science.gov (United States)

    Beatty, Thomas; Curtis, Jason; Morley, Caroline; Burrows, Adam; Montet, Benjamin; Wright, Jason

    2018-05-01

    We wish to use 15.7 hours of Spitzer time to observe two transits, one each at 3.6um and 4.5um, of the transiting brown dwarf CWW 89Ab (Nowak et al. 2017) to measure its nightside emission. This will allow us to either make the first positive identification of a brown dwarf that has formed through core accretion processes - or will provide a severe challenge to brown dwarf evolution models. CWW 89Ab is a 36.5+/-0.1 MJ, 0.937+/-0.042 RJ, brown dwarf on a 5.3 day orbit about a 5800K dwarf. The brown dwarf is a member of the 3.00+/-0.25 Gyr old open cluster Ruprecht 147 (Curtis et al. 2013). CWW 89Ab is one of two transiting brown dwarfs for which we have an isochronal age - giving us an age, a mass, and a radius that are all independent of evolutionary models. Surprisingly, Spitzer eclipse observations of CWW 89Ab (Beatty et al. 2018) show that the dayside emission requires an internal luminosity is 16 times higher than predicted by evolutionary models. In Beatty et al. (2018) we hypothesized that this is due to a stratospheric temperature inversion on CWW 89Ab's dayside. Atmospheric modeling by Molliere et al. (2015) shows that CWW 89Ab's temperature, an inversion can only happen if the atmospheric carbon-to-oxygen ratio (C/O) is close to one. Since we know that the abundances of Ruprecht 147 and CWW 89A itself (Curtis et al. 2018) are close to the Solar value of C/O 0.54, a super-stellar value of C/O 1 in CWW 89Ab would mean that the material used to form the brown dwarf was processed through CWW 89A's proto-planetary disk (Oberg et al. 2011). It would necessarily follow that CWW 89Ab formed via core accretion within the proto-planetary disk, and not through gravitational collapse. We wish to observe CWW 89Ab to determine if the dayside over-luminosity is caused by a temperature inversion. Since inversions are caused by direct stellar irradiation and impossible at night, the nightside emission should be consistent with Tint=850K if an inversion is the cause of the

  2. Interfacce e tecnologie visual 3D per conoscere, condividere e valorizzare il patrimonio culturale

    Directory of Open Access Journals (Sweden)

    Elena Ippoliti

    2012-11-01

    Full Text Available L’articolo illustra gli esiti della ricerca “Modelli informativi integrati per conoscere, valorizzare e condividere il patrimonio urbano e ambientale. Sperimentare interfacce 3D per oggetti culturali geografici: l'architettura delle informazioni e l'architettura informatica” che si è posta come principale obiettivo quello di dilatare il concetto di “modello informativo integrato”, approfondendolo, attraverso integrazioni e sovrapposizioni con diversi ambienti, nelle direzioni sia dello spazio geografico (3D-GIS e dello spazio Web (3D-WEB e 3D-GIS-WEB, sia della Realtà Aumentata e del Virtuale Aumentato. La ricerca ha mirato ad individuare sistemi tecnologici, procedurali e operativi, diversamente articolati in relazione a casi individuati, privilegiando anche tecnologie basate su strumentazioni di facile uso, a basso costo e/o open source, ma sempre affidabili relativamente alla qualità dei dati elaborati. In tale contesto si sono condotte differenti sperimentazioni, secondo vari percorsi/scale di lettura e corrispondenti organizzazioni dei dati, scegliendo come ambito privilegiato delle applicazioni il centro storico di Ascoli Piceno.

  3. Music: Creativity and Structure Transitions

    Science.gov (United States)

    Pietrocini, Emanuela

    Music, compared to other complex forms of representation, is fundamentally characterized by constant evolution and a dynamic succession of structure reference models. This is without taking into account historical perspective, the analysis of forms and styles, or questions of a semantic nature; the observation rather refers to the phenomenology of the music system. The more abstract a compositional model, the greater the number and frequency of variables that are not assimilated to the reference structure; this "interference" which happens more often than not in an apparently casual manner, modifies the creative process to varying but always substantial degrees: locally, it produces a disturbance in perceptive, formal and structural parameters, resulting more often than not in a synaesthetic experience; globally, on the other hand, it defines the terms of a transition to a new state, in which the relations between elements and components modify the behavior of the entire system from which they originated. It is possible to find examples of this phenomenon in the whole range of musical production, in particular in improvisations, in the use of the Basso Continuo, and in some contrapuntal works of the baroque period, music whose temporal dimension can depart from the limits of mensurability and symmetry to define an open compositional environment in continuous evolution.

  4. From Phoenician Nora to Punic Nora and Beyond

    Directory of Open Access Journals (Sweden)

    Stefano Finocchi

    2013-11-01

    Full Text Available Sulla base dei risultati conseguiti dalla missione dell’Università della Tuscia a Nora si esaminano i dati circa le più antiche fasi dell’insediamento fenicio di Nora in Sardegna e le prime forme di organizzazione urbana (fine dell’VIII - seconda metà del VI secolo a.C.. Si illustrano quindi gli aspetti urbanistici legati all’affermazione dell’egemonia cartaginese a Nora (dall’ultimo quarto del VI secolo a.C. e le trasformazioni urbanistiche e topografiche che interessano un settore della città, il “Colle di Tanit”, tra l’età ellenistica e le ultime fasi di vita dell’età repubblicana. Grazie ai dati delle ricognizioni territoriali, si esaminano le modalità della diffusione e dello sfruttamento delle relative risorse tra l’età fenicia e punica prima, quella romana repubblicana e imperiale poi e quella di età bizantina e basso medievale in seguito.

  5. Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury.

    Science.gov (United States)

    Nakamura, Yuka; Fujita, Yuki; Ueno, Masaki; Takai, Toshiyuki; Yamashita, Toshihide

    2011-01-21

    Myelin components that inhibit axonal regeneration are believed to contribute significantly to the lack of axonal regeneration noted in the adult central nervous system. Three proteins found in myelin, Nogo, myelin-associated glycoprotein, and oligodendrocyte-myelin glycoprotein, inhibit neurite outgrowth in vitro. All of these proteins interact with the same receptors, namely, the Nogo receptor (NgR) and paired immunoglobulin-like receptor B (PIR-B). As per previous reports, corticospinal tract (CST) regeneration is not enhanced in NgR-knock-out mice after spinal cord injury. Therefore, we assessed CST regeneration in PIR-B-knock-out mice. We found that hindlimb motor function, as assessed using the Basso mouse scale, footprint test, inclined plane test, and beam walking test, did not differ between the PIR-B-knock-out and wild-type mice after dorsal hemisection of the spinal cord. Further, tracing of the CST fibers after injury did not reveal enhanced axonal regeneration or sprouting in the CST of the PIR-B-knock-out mice. Systemic administration of NEP1-40, a NgR antagonist, to PIR-B knock-out mice did not enhance the regenerative response. These results indicate that PIR-B knock-out is not sufficient to induce extensive axonal regeneration after spinal cord injury.

  6. Electromyographic activity associated with spontaneous functional recovery after spinal cord injury in rats.

    Science.gov (United States)

    Kaegi, Sibille; Schwab, Martin E; Dietz, Volker; Fouad, Karim

    2002-07-01

    This investigation was designed to study the spontaneous functional recovery of adult rats with incomplete spinal cord injury (SCI) at thoracic level during a time course of 2 weeks. Daily testing sessions included open field locomotor examination and electromyographic (EMG) recordings from a knee extensor (vastus lateralis, VL) and an ankle flexor muscle (tibialis anterior, TA) in the hindlimbs of treadmill walking rats. The BBB score (a locomotor score named after Basso et al., 1995, J. Neurotrauma, 12, 1-21) and various measures from EMG recordings were analysed (i.e. step cycle duration, rhythmicity of limb movements, flexor and extensor burst duration, EMG amplitude, root-mean-square, activity overlap between flexor and extensor muscles and hindlimb coupling). Directly after SCI, a marked drop in locomotor ability occurred in all rats with subsequent partial recovery over 14 days. The recovery was most pronounced during the first week. Significant changes were noted in the recovery of almost all analysed EMG measures. Within the 14 days of recovery, many of these measures approached control levels. Persistent abnormalities included a prolonged flexor burst and increased activity overlap between flexor and extensor muscles. Activity overlap between flexor and extensor muscles might be directly caused by altered descending input or by maladaptation of central pattern generating networks and/or sensory feedback.

  7. Crowdfunding per il Patrimonio Culturale nei Centri Storici Minori: la Chiesa di San Michele a Savoca

    Directory of Open Access Journals (Sweden)

    Antonino Cosentino

    2016-08-01

    Full Text Available Questo articolo illustra la campagna di crowdfunding “Save the Soul of Savoca” per finanziare il restauro di un ciclo di dipinti settecenteschi nel piccolo borgo di Savoca (ME. Si presenta questa iniziativa come un modello per la salvaguardia del patrimonio culturale del nostro Paese che è vastissimo, distribuito su numerose piccole realtà locali e spesso non adeguatamente tutelato. Il finanziamento erogato dallo Stato e dagli enti locali rappresenta, ancora oggi, la fonte di sostentamento principale per le iniziative che coinvolgono il settore dei beni culturali. Tuttavia, l’attuale congiuntura economica ha favorito la nascita e la diffusione di strumenti e modalità di finanziamento alternativi attraverso i quali poter supportare il restauro del nostro Patrimonio Culturale. Il crowdfunding è il metodo che più si sta diffondendo ed è una forma di microfinanziamento dal basso finalizzato alla creazione e al supporto di un processo collaborativo tra singoli soggetti che utilizzano il proprio denaro per sostenere iniziative di singoli individui o di organizzazioni più strutturate. Molteplici sono gli esempi attuali di impiego del crowdfunding, da parte di associazioni e comitati, per il restauro di monumenti di interesse nazionale.

  8. Materiali acustici fonoisolanti e fonoassorbenti di origine vegetale - Acoustic materials of vegetable origin for sound absorption and sound insulation

    Directory of Open Access Journals (Sweden)

    Francesco Asdrubali

    2015-10-01

    Full Text Available I materiali acustici di origine vegetale possono rappresentare delle valide alternative sia dal punto di vista prestazionale che ambientale ai materiali sintetici e minerali, ma al momento attuale un esiguo numero di essi è già pronto da essere commercializzato. La presente memoria propone uno stato dell’arte su questa famiglia di materiali, fornendo le caratteristiche di fonoisolamento/assorbimento a partire dai materiali più diffusi fino a quelli meno convenzionali. Tali prodotti sono realizzati dagli scarti delle coltivazioni e delle aziende di trasformazione: ciò comporta un impatto ambientale basso se i materiali sono disponibili localmente e non in conflitto con colture alimentari. ------ Acoustic materials of vegetable origin can be a good alternative to traditional ones both from the technical and environmental point of view but very few of them are technologically mature enough to be commercialized. The present paper reports a state of the art of this family of materials, providing the acoustic characteristics starting from the most widespread and promising products to the unconventional ones. These products are realized using the residuals of the cultivation process or of the processing industry so their environmental impact is very low, if the raw materials are local and are not in contrast with food crops.

  9. Bibliometric indicators: spread reflections for a focusing and conscious use

    Directory of Open Access Journals (Sweden)

    Tessa Piazzini

    2010-04-01

    Full Text Available Nel mondo scientifico e accademico l'uso di indicatori bibliometrici è ormai largamente diffuso ed è diventato un  parametro di giudizio per assegnare fondi di ricerca e valutare i risultati degli investimenti. Lo scopo di questo articolo è quello di fornire, senza alcuna pretesa di completezza, spunti di riflessione e consigli pratici per un utilizzo consapevole degli indicatori bibliometrici più consolidati, segnalandone i limiti e le peculiarità. Oltre al più noto e discusso indicatore bibliometrico, l'Impact factor, sono stati sviluppati negli ultimi anni alcuni sistemi alternativi legati all'open acess. Le più valide alternative sono rappresentate da Scimago, strumento gratuitamente consultabile on-line nato da un gruppo di ricerca del Consejo Superior de Investigaciones Científicas (CSIC in collaborazione con alcune università spagnole e Eigenfactor, progetto di ricerca accademica non-commerciale sponsorizzato dal Bergstrom lab dell’Università di Washington. Molto affermato è infine l'H-index (o Indice di Hirsch, messo a punto nel 2005 da Jorge E. Hirsch professore all’Università della California di San Diego. Questo recente indice cerca di ridimensionare alcuni eccessi del Citation index, equilibrando e rendendo compatibili autori molto prolifici, ma con un basso numero di citazioni per articolo e studiosi meno produttivi, ma con un alto rapporto citazione/articolo.

  10. Epidemiological study on the Trichinellosis of the fox (Vulpes vulpes in Tuscany (Central Italy

    Directory of Open Access Journals (Sweden)

    Marta Magi

    2008-07-01

    Full Text Available Abstract During the years 2004-2005, 112 foxes (Vulpes vulpes and 4 badgers (Meles meles were caught in different areas of Tuscany (Central Italy and examined for Trichinella infection, using the diagnostic technique of artificial digestion through Stomacher. No animal was positive for Trichinella larvae. According to our results, Tuscany can be considered a low-risk area for trichinellosis in the fox. In this region the presence of the parasite cannot be ruled out, two cases of infection being reported in 1993. Riassunto Epidemiologia della trichinellosi della volpe (Vulpes vulpes in Toscana (Italia centrale. Nel corso degli anni 2004-2005, 112 volpi (Vulpes vulpes e 4 tassi (Meles meles sono stati catturati ed esaminati per la presenza di infestione da Trichinella in differenti aree della Toscana (Italia centrale. L'indagine di laboratorio è stata condotta mediante digestione artificiale tramite Stomacher. Nessun animale è risultato positivo. Da questi risultati si può ritenere la Toscana una regione a basso rischio di infezione. La presenza del parassita non può però essere esclusa totalmente. Infatti, nel 1993 sono stati riportati due casi di infestione.

  11. A silence full of noises: The aural environment in a miner’s life history

    Directory of Open Access Journals (Sweden)

    Francesco Bachis

    2017-12-01

    Full Text Available L’opera 4’33” di John Cage può essere letta come un tentativo di dissacrare lo spazio dell’ascolto attento della musica “colta” attraverso l’eliminazione del “suono” in un luogo in cui paradigmaticamente si punta a ridurre il “rumore”. Il setting delle storie di vita viene costruito come un luogo “del silenzio”, in cui la predisposizione tecnica e l’abilità dell’etnografo concorrono alla riduzione dei rumori di fondo e dei disturbi. Il silenzio in etnografia non può, tuttavia, essere letto soltanto come una assenza di comunicazione, per quanto “significativa” (Basso 1970, ma come un campo da esplorare anche uditivamente, che lascia emerge soundscapes e segnali corporei. A partire dalla sfida della sensory ethnography come contributo alla «risensibilizzazione» dell’antropologia (Herzfeld 2006 l’articolo presenta un frammento di storia di vita di Giovanni, anziano minatore sardo. La descrizione etnografica si concentra sulla voce di Giovanni e sull’intero spettro sonoro del luogo e dei corpi presenti, registrati tramite una videocamera. Il «silenzio pieno di rumore» (Cage 1977: 221 che emerge dall’“ascolto differito” del video consente di offrire una maggiore densità alla rammemorazione e al racconto di Giovanni.

  12. I nomi del tempo la seconda rivoluzione scientifica e il mito della freccia temporale

    CERN Document Server

    Bellone, Enrico

    1989-01-01

    Ogni persona colloca i fatti ordinandoli lungo una freccia psicologica del tempo e così distingue tra il passato e il futuro. La distinzione è netta, poiché i fatti disposti nel passato non sono modificabili, mentre quelli che si verificheranno sono, in linea di massima, solo prevedibili: non possiamo esercitare alcuna influenza sugli eventi passati, ma possiamo nutrire la speranza di condizionare, almeno in parte, quelli che non si sono ancora verificati. La questione della freccia psicologica è collegata alla circostanza per cui l'individuo ha coscienza d'essere sempre situato in un «qui e ora», così da ricordare solo certi fatti del passato e da non avere alcuna memoria del futuro. Questo stato di cose, pur manifestandosi in modo del tutto naturale, presenta però analogie con quel particolare stato di cose grazie al quale ciascuno di noi parla di oggetti che si trovano «in alto» o «in basso», sulla base di una distinzione che non è poi dissimile da quella che riguarda il «prima» e il «dopo�...

  13. Criteria for Selecting Optimal Nitrogen Fertilizer Rates for Precision Agriculture

    Directory of Open Access Journals (Sweden)

    Francesco Basso

    2011-02-01

    Full Text Available Yield rates vary spatially and maps produced by the yield monitor systems are evidence of the degree of withinfield variability. The magnitude of this variability is a good indication of the suitability of implementing a spatially variable management plan. Crop simulation models have the potential to integrate the effects of temporal and multiple stress interaction on crop growth under different environmental and management conditions. The strength of these models is their ability to account for stress by simulating the temporal interaction of stress on plant growth each day during the season. The objective of paper is to present a procedure that allows for the selection of optimal nitrogen fertilizer rates to be applied spatially on previously identified management zones through crop simulation modelling. The integration of yield maps, remote sensing imagery, ground truth measurements, electrical resistivity imaging allowed for the identifications of three distinct management zones based on their ability to produce yield and their stability over time (Basso et al., 2009. After validating the model, we simulated 7 N rates from 0 to 180 kg N/ha with a 30 kg N/ha increment. The model results illustrate the different N responses for each of the zone. The analysis allowed us to identify the optimal N rate for each of the zone based on agronomic, economic and environmental sustainability of N management.

  14. Work life balance tra limiti istituzionali e pratiche innovative

    Directory of Open Access Journals (Sweden)

    Giovanna Campanella

    2017-12-01

    Full Text Available Come rispondono le politiche di conciliazione cura-lavoro alle esigenze delle lavoratrici e dei lavoratori di nuova generazione: sempre più precari, poveri e instabili dal punto di vista reddituale e/o professionale? Con un sostanziale immobilismo politico.  Questo è il quadro che viene fuori da una rassegna delle principali politiche sociali italiane volte a supporto della genitorialità e alla garanzia dell’occupazione femminile. Il contributo mette in luce i limiti di tali politiche e coglie gli aspetti innovativi di pratiche che si sviluppano dal basso.  Al contempo, una riflessione al margine lascia aperta una importante questione sul rapporto tra flessibilità e conciliazione, ovvero tra organizzazione del lavoro e tempi di cura per la famiglia. Nell’era della rivoluzione digitale,  individuamo forti resistenze al cambiamento, sia da parte delle istituzioni, ma anche e soprattutto dal mondo produttivo, che vanta si modelli “agili” di forme di lavoro da un punto di vista formale (vedi il lavoro agile/ smart working ma che dal punto di vista sostanziale rimane radicato a modelli di contrattazione standar che non agevola né la condizioine lavorativa da un punto di vista di tutele né la conciliaizone cura lavoro e quindi l’occupazione femminile.

  15. EOCLASSICAL TRENDS OF THE SONATA IN C FOR SOLO ACCORDION BY ERNST-LOTHAR VON KNORR

    Directory of Open Access Journals (Sweden)

    CALMÎȘ DUMITRU

    2017-12-01

    Full Text Available This article presents an analysis of the Sonata in C for solo accordion written by the German composer Ernst-Lothar von Knorr and it is dedicated to the accordion producer Ernst Hohner. This musical composition was written in 1949. It represents the first creation in sonata form in the chamber repertoire for accordion from Germany. Ernst-Lothar von Knorr was influenced by the German academic school of the twentieth century and especially by one of the most prominent representatives of neoclassicism Paul Hindemith, who would later become his friend. He operates intensively with the compositional processes of neoclassicism, reflected strongly enough in the sonata for accordion. The revitalization of the forms, characteristic of compositions of the classical and pre-classical epochs (large tripartite form with episode in part I, polyphonic variations on basso ostinato in part II and the concert form in the finale, enriched by the free use of the chromatic scale and other innovations in this domain, determine clearly the approach of the Sonata in C for solo accordion to the neoclassical principles.

  16. SUL TERREMOTO PROFONDO DELLE ISOLE EOLIE DEL 23 NOVEMBRE 1954

    Directory of Open Access Journals (Sweden)

    ANTONINO GIRLANDA

    1955-06-01

    Full Text Available È accertato che la zona del basso Tirreno, comprendente il gruppo
    delle Eolie con l'isola di Ustica e parzialmente limitata dall'arco tracciato
    dalla costa occidentale della Calabria e dalla costa settentrionale
    della Sicilia, è anche sede di centri sismici profondi. Dagli studi microsismici
    fino ad oggi eseguiti risulterebbe che tali centri, la cui profondità
    è compresa tra 200 e 300 km., si dispongono lungo un arco
    parallelo all'arco costituito dall'Appennino calabro-campano, cioè lungo
    la fascia vulcanica attiva che comprende l'Etna, lo Stromboli ed
    il Vesuvio.
    Alcune caratteristiche della zona (vulcanismo attivo o recentemente
    spento, notevoli profondità marine, anomalia isostatica positiva
    la rendono, sotto certi aspetti, somigliante ad alcuni tratti dell'arco
    circnm-pacifico, che, secondo l'elaborazione statistica di Gutenberg e
    Richter (11, è sede del 90r/c ca. dei terremoti con profondità compresa
    tra 60 e 300 km.

  17. Criteria for Selecting Optimal Nitrogen Fertilizer Rates for Precision Agriculture

    Directory of Open Access Journals (Sweden)

    Bruno Basso

    Full Text Available Yield rates vary spatially and maps produced by the yield monitor systems are evidence of the degree of withinfield variability. The magnitude of this variability is a good indication of the suitability of implementing a spatially variable management plan. Crop simulation models have the potential to integrate the effects of temporal and multiple stress interaction on crop growth under different environmental and management conditions. The strength of these models is their ability to account for stress by simulating the temporal interaction of stress on plant growth each day during the season. The objective of paper is to present a procedure that allows for the selection of optimal nitrogen fertilizer rates to be applied spatially on previously identified management zones through crop simulation modelling. The integration of yield maps, remote sensing imagery, ground truth measurements, electrical resistivity imaging allowed for the identifications of three distinct management zones based on their ability to produce yield and their stability over time (Basso et al., 2009. After validating the model, we simulated 7 N rates from 0 to 180 kg N/ha with a 30 kg N/ha increment. The model results illustrate the different N responses for each of the zone. The analysis allowed us to identify the optimal N rate for each of the zone based on agronomic, economic and environmental sustainability of N management.

  18. Criteria for Selecting Optimal Nitrogen Fertilizer Rates for Precision Agriculture

    Directory of Open Access Journals (Sweden)

    Bruno Basso

    2009-12-01

    Full Text Available Yield rates vary spatially and maps produced by the yield monitor systems are evidence of the degree of withinfield variability. The magnitude of this variability is a good indication of the suitability of implementing a spatially variable management plan. Crop simulation models have the potential to integrate the effects of temporal and multiple stress interaction on crop growth under different environmental and management conditions. The strength of these models is their ability to account for stress by simulating the temporal interaction of stress on plant growth each day during the season. The objective of paper is to present a procedure that allows for the selection of optimal nitrogen fertilizer rates to be applied spatially on previously identified management zones through crop simulation modelling. The integration of yield maps, remote sensing imagery, ground truth measurements, electrical resistivity imaging allowed for the identifications of three distinct management zones based on their ability to produce yield and their stability over time (Basso et al., 2009. After validating the model, we simulated 7 N rates from 0 to 180 kg N/ha with a 30 kg N/ha increment. The model results illustrate the different N responses for each of the zone. The analysis allowed us to identify the optimal N rate for each of the zone based on agronomic, economic and environmental sustainability of N management.

  19. Organic luminescent materials. First results on synthesis and characterization of Alq{sub 3} thin films

    Energy Technology Data Exchange (ETDEWEB)

    Baldacchini, G.; Gagliardi, S.; Montereali, R.M.; Pace, A. [ENEA, Centro Ricerche Frascati, Frascati, RM (Italy). Div. Fisica Applicata; Balaji Pode, R. [Nagpur University, Nagpur (India). Dept. of Physics

    2000-07-01

    Inorganic semiconductor diodes brought a technological revolution in the field of efficient light and laser sources in the last 20 years. New development in this field are expected from organic compounds, thanks to their low cost of synthesis and the relative easiness of growth as thin films. In particular, electrically pumped luminescent devices based on organic thin layers are among the most promising systems for next generation flat panel displays and semiconductor lasers. The tris - (8-hydroxy quinoline)-aluminium complex-Alq{sub 3} - is one of the most studied electro luminescent materials. In this paper, after a short introduction regarding historical development in the field, are reported preliminary results on the growth of Alq{sub 3} films and on their optical and spectroscopic characterization. [Italian] Negli ultimi 20 anni i diodi semiconduttori hanno portato una rivoluzione tecnologica nel campo delle sorgenti luminose e laser. Un nuovo sviluppo possibile in questo campo sono i composti organici, grazie al basso costo di sintesi e la relativa facilita' di crescerli in forma di film sottile. In particolare, dispositivi luminescenti pompati elettricamente basati su film sottili di materiali organici sono promettenti per una nuova generazione di display per schermi piatti e laser a Alq{sub 3} e' uno dei materiali elettroluminescenti piu' studiati. In questo rapporto, dopo una breve introduzione sullo sviluppo storico in questo campo, presentiamo i nostri primi risultati sulla crescita e caratterizzazione ottica di film di Alq{sub 3}.

  20. Identifying the Long-Term Role of Inducible Nitric Oxide Synthase after Contusive Spinal Cord Injury Using a Transgenic Mouse Model

    Directory of Open Access Journals (Sweden)

    Dominic M. Maggio

    2017-01-01

    Full Text Available Inducible nitric oxide synthase (iNOS is a potent mediator of oxidative stress during neuroinflammation triggered by neurotrauma or neurodegeneration. We previously demonstrated that acute iNOS inhibition attenuated iNOS levels and promoted neuroprotection and functional recovery after spinal cord injury (SCI. The present study investigated the effects of chronic iNOS ablation after SCI using inos-null mice. iNOS−/− knockout and wild-type (WT control mice underwent a moderate thoracic (T8 contusive SCI. Locomotor function was assessed weekly, using the Basso Mouse Scale (BMS, and at the endpoint (six weeks, by footprint analysis. At the endpoint, the volume of preserved white and gray matter, as well as the number of dorsal column axons and perilesional blood vessels rostral to the injury, were quantified. At weeks two and three after SCI, iNOS−/− mice exhibited a significant locomotor improvement compared to WT controls, although a sustained improvement was not observed during later weeks. At the endpoint, iNOS−/− mice showed significantly less preserved white and gray matter, as well as fewer dorsal column axons and perilesional blood vessels, compared to WT controls. While short-term antagonism of iNOS provides histological and functional benefits, its long-term ablation after SCI may be deleterious, blocking protective or reparative processes important for angiogenesis and tissue preservation.

  1. Fenbendazole improves pathological and functional recovery following traumatic spinal cord injury.

    Science.gov (United States)

    Yu, C G; Singh, R; Crowdus, C; Raza, K; Kincer, J; Geddes, J W

    2014-01-03

    During a study of spinal cord injury (SCI), mice in our colony were treated with the anthelmintic fenbendazole to treat pinworms detected in other mice not involved in the study. As this was not part of the original experimental design, we subsequently compared pathological and functional outcomes of SCI in female C57BL/6 mice who received fenbendazole (150 ppm, 8 mg/kg body weight/day) for 4 weeks prior to moderate contusive SCI (50 kdyn force) as compared to mice on the same diet without added fenbendazole. The fenbendazole-treated mice exhibited improved locomotor function, determined using the Basso mouse scale, as well as improved tissue sparing following contusive SCI. Fenbendazole may exert protective effects through multiple possible mechanisms, one of which is inhibition of the proliferation of B lymphocytes, thereby reducing antibody responses. Autoantibodies produced following SCI contribute to the axon damage and locomotor deficits. Fenbendazole pretreatment reduced the injury-induced CD45R-positive B cell signal intensity and IgG immunoreactivity at the lesion epicenter 6 weeks after contusive SCI in mice, consistent with a possible effect on the immune response to the injury. Fenbendazole and related benzimadole antihelmintics are FDA approved, exhibit minimal toxicity, and represent a novel group of potential therapeutics targeting secondary mechanisms following SCI. Copyright © 2013. Published by Elsevier Ltd.

  2. What drives insurer participation and premiums in the Federally-Facilitated Marketplace?

    Science.gov (United States)

    Abraham, Jean Marie; Drake, Coleman; McCullough, Jeffrey S; Simon, Kosali

    2017-12-01

    We investigate determinants of market entry and premiums within the context of the Affordable Care Act's Marketplaces for individual insurance. Using Bresnahan and Reiss (1991) as the conceptual framework, we study how competition and firm heterogeneity relate to premiums in 36 states using Federally Facilitated or Supported Marketplaces in 2016. Our primary data source is the Qualified Health Plan Landscape File, augmented with market characteristics from the American Community Survey and Area Health Resource File as well as insurer-level information from federal Medical Loss Ratio annual reports. We first estimate a model of insurer entry and then investigate the relationship between a market's predicted number of entrants and insurer-level premiums. Our entry model results suggest that competition is increasing with the number of insurers, most notably as the market size increases from 3 to 4 entrants. Results from the premium regression suggest that each additional entrant is associated with approximately 4% lower premiums, controlling for other factors. An alternative explanation for the relationship between entrants and premiums is that more efficient insurers (who can price lower) are the ones that enter markets with many entrants, and this is reflected in lower premiums. An exploratory analysis of insurers' non-claims costs (a proxy for insurer efficiency) reveals that average costs among entrants are rising slightly with the number of insurers in the market. This pattern does not support the hypothesis that premiums decrease with more entrants because those entrants are more efficient, suggesting instead that the results are being driven mostly by price competition.

  3. Proceedings of the Northwest regional energy conference

    Energy Technology Data Exchange (ETDEWEB)

    Denman, A S; Comstock, D R [eds.

    1978-12-01

    The conference was directed toward two main objectives. First, a major portion of the proceedings were to focus on the policies, programs, and priorities of the new US DOE, and their relationships to the Pacific Northwest region. Second, the conference was to explore specific energy issues of regional significance and provide an opportunity for regional feedback on energy policies. The 10 sessions of the conference are Keynote Session: Congress, and the National Energy Plan Sen. Henry Jackson; National Perspectives on Energy Issues (I): An Overview of the NEP, Programs and Priorities of DOE (Alvin Alm and NEP - Conservation and Solar Applications (Don Beattie); and Luncheon address - Alaska Energy Issues (Robert LeResche); National Perspectives on Energy Issues (II): Utility Rate Reform - National Provisions and Relationships to the Pacific Northwest (David Bardin) and Technology for Energy and Long Term Short Alternatives (Robert Thorne); Concurrent Interest Group Sessions: State and Local Roles in Energy Planning and Decision-Making and Industry and University Roles in DOE Research and Programs; Banquet address. The US Energy Future (James Schlesinger); Regional Perspectives on Energy Issues: DOE-X - Organization and Response to Regional Needs (Randall Hardy). What Comes After Number 13 (Sterling Munro), Hanford 1978 (Alex Fremling), and Low Head Hydro and Geothermal (Richard Wood); Lucheon address - The Washington Perspective on Energy (Dixie Lee Ray); Regional Power Planning (Panel); and Conference Wrap Up Session. (MCW)

  4. PRESTO low-level waste transport and risk assessment code

    International Nuclear Information System (INIS)

    Little, C.A.; Fields, D.E.; McDowell-Boyer, L.M.; Emerson, C.J.

    1981-01-01

    PRESTO (Prediction of Radiation Effects from Shallow Trench Operations) is a computer code developed under US Environmental Protection Agency (EPA) funding to evaluate possible health effects from shallow land burial trenches. The model is intended to be generic and to assess radionuclide transport, ensuing exposure, and health impact to a static local population for a 1000-y period following the end of burial operations. Human exposure scenarios considered by the model include normal releases (including leaching and operational spillage), human intrusion, and site farming or reclamation. Pathways and processes of transit from the trench to an individual or population inlude: groundwater transport, overland flow, erosion, surface water dilution, resuspension, atmospheric transport, deposition, inhalation, and ingestion of contaminated beef, milk, crops, and water. Both population doses and individual doses are calculated as well as doses to the intruder and farmer. Cumulative health effects in terms of deaths from cancer are calculated for the population over the thousand-year period using a life-table approach. Data bases are being developed for three extant shallow land burial sites: Barnwell, South Carolina; Beatty, Nevada; and West Valley, New York

  5. Can taking the perspective of an expert debias human decisions? The case for risky and delayed gains.

    Directory of Open Access Journals (Sweden)

    Michal eBialek

    2014-09-01

    Full Text Available In several reported previously studies, participants increased their normative correctness after being instructed to think hypothetically, specifically taking the perspective of an expert or researcher (Beatty & Thompson 2012, Morsanyi & Handley 2012. The goal of this paper was to investigate how this manipulation affects risky or delayed payoffs. In two studies, participants (n=193 were tested online (in exchange for money using the adjusting procedure. Individuals produced certain/immediate equivalents for risky/delayed gains. Participants in the control group were solving the problem from their own perspective, while participants in the experimental group were asked to imagine what would a reliable and honest advisor advise them to do.Study 1 showed that when taking the perspective of an expert, participants in experimental group became more risk aversive compared to participants in the control group. Additionally, their certain equivalents diverged from the Expected Value (EV to a greater extent. The results obtained from the experimental group in Study 2 suggest that participants became less impulsive, which means they tried to inhibit their preferences. This favors the explanation, which suggests that the perspective shift forced individuals to override their intuitions with the social norms. Individuals expect to be blamed for impatience or risk taking thus expected an expert to advise them to be more patient and risk aversive.

  6. Low-level waste management in the South. Task 4.2 - long-term care requirements

    International Nuclear Information System (INIS)

    1983-01-01

    This paper provides an analysis of the long-term care requirements of low-level radioactive waste disposal facilities. Among the topics considered are the technical requirements for long-term care, the experiences of the three inactive and three active commercial disposal facilities concerning perpetual care and maintenance, and the financial management of a perpetual care fund. In addition, certain recommendations for the establishment of a perpetual care fund are provided. The predominant method of disposing of low-level radioactive wastes is shallow land burial. After studying alternative methods of disposal, the U.S Nuclear Regulatory Commission (NRC) concluded that there are no compelling reasons for abandoning this disposal method. Of the 22 shallow land burial facilities in the U.S., the federal government maintains 14 active and two inactive disposal sites. There are three active (Barnwell, South Carolina; Hanford, Washington; and Beatty, Nevada) and three inactive commercial disposal facilities (Maxey Flats, Kentucky; Sheffield, Illinois; and West Valley, New York). The life of a typical facility can be broken into five phases: preoperational, operational, closure, postclosure observation and maintenance, and institutional control. Long-term care of a shallow land burial facility will begin with the disposal site closure phase and continue through the postclosure observation and maintenance and institutional control phases. Since the postclosure observation and maintenance phase will last about five years and the institutional control phase 100 years, the importance of a well planned long-term care program is apparent. 26 references, 1 table

  7. Impact of technology applications to the management of low-level radioactive wastes

    International Nuclear Information System (INIS)

    Devgun, J.S.

    1989-01-01

    Low-level radioactive wastes are generated from reactor sources (nuclear power reactors) as well as from nonreactor sources (academic, medical, governmental, and industrial). In recent years, about 50,000 m 3 per year of such wastes have been generated in the United States and about 10,000 m 3 per year in Canada. Direct disposal of these wastes in shallow ground has been a favored method in both countries in the past. In the United States, three operating commercial sites at Barnwell, South Carolina; Beatty, Nevada; and Richland, Washington, receive most of the commercial low-level waste generated. However, with recent advances in waste management, technologies are being applied to achieve optimum goals in terms of protection of human health and safety and the environment, as well as cost-effectiveness. These technologies must be applied from the generation sources through waste minimization and optimum segregation -- followed by waste processing, conditioning, storage, and disposal. A number of technologies that are available and can be applied as appropriate -- given the physical, chemical, and radiological characteristics of the waste -- include shredding, baling, compaction, supercompaction, decontamination, incineration, chemical treatment/conditioning, immobilization, and packaging. Interim and retrievable storage can be accomplished in a wide variety of storage structures, and several types of engineered disposal facility designs are now available. By applying an integrated approach to radioactive waste management, potential adverse impacts on human health and safety and the environment can be minimized. 15 refs., 1 fig., 1 tab

  8. Systems Thinking Versus Population Thinking: Genotype Integration and Chromosomal Organization 1930s-1950s.

    Science.gov (United States)

    Lamm, Ehud

    2015-11-01

    This article describes how empirical discoveries in the 1930s-1950s regarding population variation for chromosomal inversions affected Theodosius Dobzhansky and Richard Goldschmidt. A significant fraction of the empirical work I discuss was done by Dobzhansky and his coworkers; Goldschmidt was an astute interpreter, with strong and unusual commitments. I argue that both belong to a mechanistic tradition in genetics, concerned with the effects of chromosomal organization and systems on the inheritance patterns of species. Their different trajectories illustrate how scientists' commitments affect how they interpret new evidence and adjust to it. Dobzhansky was moved to revised views about selection, while Goldschmidt moved his attention to different genetic phenomena. However different, there are significant connections between the two that enrich our understanding of their views. I focus on two: the role of developmental considerations in Dobzhansky's thought and the role of neutrality and drift in Goldschmidt's evolutionary account. Dobzhansky's struggle with chromosomal variation is not solely about competing schools of thought within the selectionist camp, as insightfully articulated by John Beatty, but also a story of competition between selectionist thinking and developmental perspectives. In contraposition, Goldschmidt emphasized the role of low penetrance mutations that spread neutrally and pointed out that drift could result from developmental canalization. This account adds to the dominant story about Goldschmidt's resistance to the splitting of development from genetics, as told by Garland Allen and Michael Dietrich. The story I tell illustrates how developmental thinking and genetic thinking conflicted and influenced researchers with different convictions about the significance of chromosomal organization.

  9. Rose garden promises of intelligent tutoring systems: Blossom or thorn

    Science.gov (United States)

    Shute, Valerie J.

    1991-01-01

    Intelligent tutoring systems (ITS) have been in existence for over a decade. However, few controlled evaluation studies have been conducted comparing the effectiveness of these systems to more traditional instruction methods. Two main promises of ITSs are examined: (1) Engender more effective and efficient learning in relation to traditional formats; and (2) Reduce the range of learning outcome measures where a majority of individuals are elevated to high performance levels. Bloom (1984) has referred to these as the two sigma problem; to achieve two standard deviation improvements with tutoring over traditional instruction methods. Four ITSs are discussed in relation to the two promises. These tutors have undergone systematic, controlled evaluations: (1) The LISP tutor (Anderson Farrell and Sauers, 1984); (2) Smithtown (Shute and Glaser, in press); (3) Sherlock (Lesgold, Lajoie, Bunzo and Eggan, 1990); and (4) The Pascal ITS (Bonar, Cunningham, Beatty and Well, 1988). Results show that these four tutors do accelerate learning with no degradation in final outcome. Suggestions for improvements to the design and evaluation of ITSs are discussed.

  10. The Timber Mountain magmato-thermal event: An intense widespread culmination of magmatic and hydrothermal activity at the southwestern Nevada volcanic field

    International Nuclear Information System (INIS)

    Jackson, M.R. Jr.

    1988-05-01

    Eruption of the Rainier Mesa and Ammonia Tanks Members Timber Mountain Tuff at about 11.5 and 11.3 Ma, respectively, resulted in formation of the timber Mountain (TM) caldera; new K-Ar ages show that volcanism within and around the TM caldera continued for about 1 m.y. after collapse. Some TM age magmatic activity took place west and southeast of the TM caldera in the Beatty -- Bullfrog Hills and Shoshone Mountain areas, suggesting that volcanic activity at the TM caldera was an intense expression of an areally extensive magmatic system active from about 11.5 to 10Ma. Epithermal Au-Ag, Hg and fluorite mineralization and hydrothermal alteration are found in both within and surrounding the Timber Mountain -- Oasis Valley caldera complex. New K-Ar ages date this hydrothermal activity between about 13 and 10 Ma, largely between about 11.5 and 10 Ma, suggesting a genetic relation of hydrothermal activity to the TM magmatic system

  11. PRESTO-II: a low-level waste environmental transport and risk assessment code

    Energy Technology Data Exchange (ETDEWEB)

    Fields, D.E.; Emerson, C.J.; Chester, R.O.; Little, C.A.; Hiromoto, G.

    1986-04-01

    PRESTO-II (Prediction of Radiation Effects from Shallow Trench Operations) is a computer code designed for the evaluation of possible health effects from shallow-land and, waste-disposal trenches. The model is intended to serve as a non-site-specific screening model for assessing radionuclide transport, ensuing exposure, and health impacts to a static local population for a 1000-year period following the end of disposal operations. Human exposure scenarios considered include normal releases (including leaching and operational spillage), human intrusion, and limited site farming or reclamation. Pathways and processes of transit from the trench to an individual or population include ground-water transport, overland flow, erosion, surface water dilution, suspension, atmospheric transport, deposition, inhalation, external exposure, and ingestion of contaminated beef, milk, crops, and water. Both population doses and individual doses, as well as doses to the intruder and farmer, may be calculated. Cumulative health effects in terms of cancer deaths are calculated for the population over the 1000-year period using a life-table approach. Data are included for three example sites: Barnwell, South Carolina; Beatty, Nevada; and West Valley, New York. A code listing and example input for each of the three sites are included in the appendices to this report.

  12. A critical exploration of "Working Together, Learning Together"--does it meet the learning needs of nurses?

    Science.gov (United States)

    Walshe, Amanda

    2003-10-01

    Recent government educational initiatives have emphasised the need for lifelong learning to facilitate and equip nurses with the appropriate knowledge and skills to operate in a dynamic healthcare delivery system. In this paper I will critically explore a recent educational framework from an educational ideology and curriculum design perspective. It is recognised that any educational program cannot be devised or constructed in a socio-political vacuum and any developments must acknowledge this influence on the context in which nurse education operates. The framework is debated from an ideological perspective and I surmise that an ideological change from Romanticism to Revisionism will facilitate change in curriculum design that is in keeping with the realties of healthcare needs. The educational initiative is explored from a curriculum design perspective utilising Beattie's Fourfold Model. I further surmise that the educational initiative fails to acknowledge the uniqueness of nursing knowledge and the integral learning processes such as reflection thus marginalising nursing as a profession. In this paper I suggest that any educational initiative must recognise the evolving role of nursing, the profession and the realties of healthcare systems to ensure the present and future workforce is skilled and empowered to aspire to these multifaceted demands.

  13. The 1986 state-by-state assessment of low-level radioactive wastes received at commercial disposal sites

    International Nuclear Information System (INIS)

    1987-12-01

    The data are grouped and presented by compact regions. The data include activity and volume by waste classes, generator type, and disposal site. The report uses the volume of low-level waste reported as received at each commercial disposal site as the national baseline figure. A volume of 1,804,998 cubic feet (51,113 cubic meters) of radioactive waste containing 233,726 curies of activity was reported disposed at the commercial sites in 1986. The total volume and curie values tabulated for each state were obtained directly from the commercial disposal site operators. The total is the sum of the volume and radioactivity reported by Chem Nuclear Systems, Inc., and US Ecology for each state. Sixty-three percent of low-level waste volumes disposed at commercial sites was assigned to the state of origin. These volumes represent those disposed at Beatty and Barnwell disposal sites. Thirty-seven percent, or 665,066 cubic feet (18,831 cubic meters), of the waste disposed in the US in 1986 went to the Richland site. 8 refs., 75 figs., 4 tabs

  14. Low-level radioactive waste management technology development

    International Nuclear Information System (INIS)

    Coleman, J.A.

    1985-01-01

    Although reviews of disposal practices and site performance indicated that there were no releases to the environment that would affect public health and safety, it became clear that: (a) several burial grounds were not performing as expected; (b) long-term maintenance of closed trenches could be a costly problem, and (c) more cost-effective methods could be developed for the treatment, packing, and disposal of low-level waste. As a result of these reviews, the Department of Energy developed the Low-level Waste Management Program to seek improvements in existing practices, correct obvious deficiencies, and develop site closure techniques that would avoid expensive long-term maintenance and monitoring. Such technology developments provide a better understanding of the physical and technical mechanisms governing low-level waste treatment and disposal and lead to improvement in the performance of disposal sites. The primary means of disposal of low-level waste has been the accepted and regulated practice of shallow land disposal, i.e., placement of low-level waste in trenches 5 to 10 meters deep with several meters of special soil cover. Department of Energy waste is primarily disposed at six major shallow land disposal sites. Commercial waste is currently disposed of at three major sites in the nation - Barnwell, South Carolina; Richland, Washington; and Beatty, Nevada. In the late 1970's public concern arose regarding the management practices of sites operated by the civilian sector and by the Department of Energy

  15. PRESTO-II: a low-level waste environmental transport and risk assessment code

    International Nuclear Information System (INIS)

    Fields, D.E.; Emerson, C.J.; Chester, R.O.; Little, C.A.; Hiromoto, G.

    1986-04-01

    PRESTO-II (Prediction of Radiation Effects from Shallow Trench Operations) is a computer code designed for the evaluation of possible health effects from shallow-land and, waste-disposal trenches. The model is intended to serve as a non-site-specific screening model for assessing radionuclide transport, ensuing exposure, and health impacts to a static local population for a 1000-year period following the end of disposal operations. Human exposure scenarios considered include normal releases (including leaching and operational spillage), human intrusion, and limited site farming or reclamation. Pathways and processes of transit from the trench to an individual or population include ground-water transport, overland flow, erosion, surface water dilution, suspension, atmospheric transport, deposition, inhalation, external exposure, and ingestion of contaminated beef, milk, crops, and water. Both population doses and individual doses, as well as doses to the intruder and farmer, may be calculated. Cumulative health effects in terms of cancer deaths are calculated for the population over the 1000-year period using a life-table approach. Data are included for three example sites: Barnwell, South Carolina; Beatty, Nevada; and West Valley, New York. A code listing and example input for each of the three sites are included in the appendices to this report

  16. Digital Geologic Map of the Nevada Test Site and Vicinity, Nye, Lincoln, and Clark Counties, Nevada, and Inyo County, California

    Science.gov (United States)

    Slate, Janet L.; Berry, Margaret E.; Rowley, Peter D.; Fridrich, Christopher J.; Morgan, Karen S.; Workman, Jeremiah B.; Young, Owen D.; Dixon, Gary L.; Williams, Van S.; McKee, Edwin H.; Ponce, David A.; Hildenbrand, Thomas G.; Swadley, W.C.; Lundstrom, Scott C.; Ekren, E. Bartlett; Warren, Richard G.; Cole, James C.; Fleck, Robert J.; Lanphere, Marvin A.; Sawyer, David A.; Minor, Scott A.; Grunwald, Daniel J.; Laczniak, Randell J.; Menges, Christopher M.; Yount, James C.; Jayko, Angela S.

    1999-01-01

    This digital geologic map of the Nevada Test Site (NTS) and vicinity, as well as its accompanying digital geophysical maps, are compiled at 1:100,000 scale. The map compilation presents new polygon (geologic map unit contacts), line (fault, fold axis, metamorphic isograd, dike, and caldera wall) and point (structural attitude) vector data for the NTS and vicinity, Nye, Lincoln, and Clark Counties, Nevada, and Inyo County, California. The map area covers two 30 x 60-minute quadrangles-the Pahute Mesa quadrangle to the north and the Beatty quadrangle to the south-plus a strip of 7.5-minute quadrangles on the east side-72 quadrangles in all. In addition to the NTS, the map area includes the rest of the southwest Nevada volcanic field, part of the Walker Lane, most of the Amargosa Desert, part of the Funeral and Grapevine Mountains, some of Death Valley, and the northern Spring Mountains. This geologic map improves on previous geologic mapping of the same area (Wahl and others, 1997) by providing new and updated Quaternary and bedrock geology, new geophysical interpretations of faults beneath the basins, and improved GIS coverages. Concurrent publications to this one include a new isostatic gravity map (Ponce and others, 1999) and a new aeromagnetic map (Ponce, 1999).

  17. Evaluation of shale hosted low-level waste disposal sites in semi-arid environments: Final report

    International Nuclear Information System (INIS)

    Roggenthen, W.M.; Rahn, P.H.; Arthur, R.C.; Miller, J.R.; Bangsund, W.J.; Eberlin, J.

    1985-09-01

    This report covers the findings of a multidisciplinary investigation intended to delineate critical factors and concerns associated with shale hosted, low-level radioactive waste disposal sites located in semiarid environments. The investigations focus primarily upon concerns regarding the hydrology, geochemistry, and meteorology of such an environment. The studies described within this report specifically do not constitute an evaluation of any one particular site nor even a particular class of sites. Rather, it is the intention of the report to present data and insights that would assist private concerns and governmental agencies in the efficient and prudent development of such disposal areas. This report assumes that the hypothetical waste site in question would be developed as a trench type operation similar to that used at Barnwell, South Carolina, with variations upon the techniques used at Beatty Flat, Nevada, and Hanford, Washington. The trench design (Figures 1 and 2) is assumed to be similar to that generic design described in ''Procedures and Technology for Shallow Land Burial, DOE/LLw-13Td, 1983) although it is also assumed that improvements and adaptations will be made upon this basic design to meet the individual needs of a particular site. During the preparation of this report it became apparent that new types of trench design are being studied. Discussions of these trench design proposals are not central to this report. The examples of trench design in Figures 1 and 2 are presented only to give an idea as to the general philosophy of construction of shallow burial facilities

  18. Does managerial behavior of managing earnings mitigate the relationship between corporate governance and firm value? Evidence from an emerging market

    Directory of Open Access Journals (Sweden)

    Mian Sajid Nazir

    2018-06-01

    Full Text Available The relationship between corporate governance and managerial choices for value creation is a topic of continuing interest for researchers. One of most significant managerial decisions that affect value is Discretionary Earnings Management (DEM which is the judgmental adjustments in firm's reported accounting earnings by managers to upsurge firm value temporarily. Effective corporate governance structure to control this opportunistic behavior of mangers can presumably make accounting earnings more reliable and more informative for the stakeholders and hence, increase firm value. Based on 1944 firm year observations for listed firms in Pakistan, this study aims at to analyze the role of corporate governance in enhancing firm value along with the moderating role of DEM using models proposed by Kasznik (1999 and Beatty, Ke, & Petroni (2002 for detecting earnings management practices of managers. The results report that corporate governance significantly and positively influences firm value confirming the positive role of corporate governance in mitigating agency problem and enhancing the firm value. Moreover, corporate governance mechanisms may mitigate the managers’ opportunistic behavior of manipulating the reported earnings. Furthermore, the results report that the behavior of managers is opportunistic towards managing earnings and they are destroying the current and subsequent firm value by manipulating the reported accounting earning. Finally, this opportunistic behavior of managers to manipulate earnings is negatively moderating the well-established positive relationship of corporate governance and firm value. Keywords: Corporate governance, Firm value, Discretionary earnings management, Opportunistic behavior, Kasznik model, Moderating effect

  19. Resistivity profiling for mapping gravel layers that may control contaminant migration at the Amargosa Desert Research Site, Nevada

    Science.gov (United States)

    Lucius, Jeffrey E.; Abraham, Jared D.; Burton, Bethany L.

    2008-01-01

    Gaseous contaminants, including CFC 113, chloroform, and tritiated compounds, move preferentially in unsaturated subsurface gravel layers away from disposal trenches at a closed low-level radioactive waste-disposal facility in the Amargosa Desert about 17 kilometers south of Beatty, Nevada. Two distinct gravel layers are involved in contaminant transport: a thin, shallow layer between about 0.5 and 2.2 meters below the surface and a layer of variable thickness between about 15 and 30 meters below land surface. From 2003 to 2005, the U.S. Geological Survey used multielectrode DC and AC resistivity surveys to map these gravel layers. Previous core sampling indicates the fine-grained sediments generally have higher water content than the gravel layers or the sediments near the surface. The relatively higher electrical resistivity of the dry gravel layers, compared to that of the surrounding finer sediments, makes the gravel readily mappable using electrical resistivity profiling. The upper gravel layer is not easily distinguished from the very dry, fine-grained deposits at the surface. Two-dimensional resistivity models, however, clearly identify the resistive lower gravel layer, which is continuous near the facility except to the southeast. Multielectrode resistivity surveys provide a practical noninvasive method to image hydrogeologic features in the arid environment of the Amargosa Desert.

  20. Financial assurances

    International Nuclear Information System (INIS)

    Paton, R.F.

    1990-01-01

    US Ecology is a full service waste management company. The company operates two of the nation's three existing low-level radioactive waste (LLRW) disposal facilities and has prepared and submitted license applications for two new LLRW disposal facilities in California and Nebraska. The issue of financial assurances is an important aspect of site development and operation. Proper financial assurances help to insure that uninterrupted operation, closure and monitoring of a facility will be maintained throughout the project's life. Unfortunately, this aspect of licensing is not like others where you can gauge acceptance by examining approved computer codes, site performance standards or applying specific technical formulas. There is not a standard financial assurance plan. Each site should develop its requirements based upon the conditions of the site, type of design, existing state or federal controls, and realistic assessments of future financial needs. Financial assurances at U.S. Ecology's existing sites in Richland, Washington, and Beatty, Nevada, have been in place for several years and are accomplished in a variety of ways by the use of corporate guarantees, corporate capital funds, third party liability insurance, and post closure/long-term care funds. In addressing financial assurances, one can divide the issue into three areas: Site development/operations, third party damages, and long-term care/cleanup

  1. Mixed convection heat transfer between a steam/non-condensable gas mixture and an inclined finned tube bundle

    Energy Technology Data Exchange (ETDEWEB)

    De Cachard, F.; Lompersky, S.; Monauni, G.R. [Paul Scherrer Institute, Villigen (Switzerland). Thermal Hydraulic Lab.

    1999-07-01

    An experimental and analytical program was performed at PSI (Paul Scherrer Institute) to study the performance of a finned-tube condenser in the presence of non-condensable gases at low gas mass fluxes. The model developed for this application includes mixed convection heat transfer between the vapour/non-condensable mixture and the finned tubes, heat conduction through the fins and tubes, and evaporative heat transfer inside the tubes. On the gas, heat transfer correlations are used, and the condensation rate is calculated using the heat/mass transfer analogy. A combination of various available correlations for forced convection in staggered finned tube bundles is used, together with a correction accounting for superimposed natural convection. For the condensate heat transfer resistance, the beatty and Katz model for gravity driven liquid films on the tubes is used. The fine efficiency is accounted for using classical iterative calculations. Evaporative heat transfer inside the tubes is predicted using the Chen correlation. The finned tube condenser model has been assessed against data obtained at the PSI LINX facility with two test condensers. For the 62 LINX experiments performed, the model predictions are very good, i.e., less then 10% standard deviation between experimental and predicted results.

  2. Socioeconomic profile of Nye County, Nevada: Community services inventory

    International Nuclear Information System (INIS)

    1986-09-01

    The Nevada Nuclear Waste Storage Investigations Project is preparing socioeconomic profiles of Nye County, Nevada, and communities in Nye County that could be affected by siting, construction, operation, and decommissioning of a high-level nuclear waste repository at Yucca Mountain, located in Nye County. These profiles serve as a data base for evaluating local community service impacts; store existing socioeconomic data in a uniform, readily accessible format; identify the need for additional data; and assist in developing a plan for monitoring and mitigating any significant adverse impacts that may be associated with site characterization and potential repository development. This element of the socioeconomic profiles contains an inventory of community services provided by local, county, and state agencies and volunteer organizations to residents of Amargosa Valley, Beatty, and Pahrump. Services inventoried for each community include housing, growth management, general government, education, police protection, transportation networks, public clinics, private health personnel, parks and recreation, social services, libraries, ambulances, electric power, heating fuel, water, sewers and wastewater treatment, solid waste, and fire protection. The report includes a summary overview of service providers in Nye County, discussions of services provided to residents of the three communities, and summary tables. Data presented in this profile were collected through early 1985. Data collection efforts are ongoing and this profile will be updated periodically

  3. Real-gas effects 1: Simulation of ideal gas flow by cryogenic nitrogen and other selected gases

    Science.gov (United States)

    Hall, R. M.

    1980-01-01

    The thermodynamic properties of nitrogen gas do not thermodynamically approximate an ideal, diatomic gas at cryogenic temperatures. Choice of a suitable equation of state to model its behavior is discussed and the equation of Beattie and Bridgeman is selected as best meeting the needs for cryogenic wind tunnel use. The real gas behavior of nitrogen gas is compared to an ideal, diatomic gas for the following flow processes: isentropic expansion; normal shocks; boundary layers; and shock wave boundary layer interactions. The only differences in predicted pressure ratio between nitrogen and an ideal gas that may limit the minimum operating temperatures of transonic cryogenic wind tunnels seem to occur at total pressures approaching 9atmospheres and total temperatures 10 K below the corresponding saturation temperature, where the differences approach 1 percent for both isentropic expansions and normal shocks. Several alternative cryogenic test gases - air, helium, and hydrogen - are also analyzed. Differences in air from an ideal, diatomic gas are similar in magnitude to those of nitrogen. Differences for helium and hydrogen are over an order of magnitude greater than those for nitrogen or air. Helium and hydrogen do not approximate the compressible flow of an ideal, diatomic gas.

  4. Electrochemical control of a DNA Holliday Junction nanoswitch by Mg2+ ions.

    Science.gov (United States)

    Ferapontova, E E; Mountford, C P; Crain, J; Buck, A H; Dickinson, P; Beattie, J S; Ghazal, P; Terry, J G; Walton, A J; Mount, A R

    2008-11-15

    The molecular conformation of a synthetic branched, 4-way DNA Holliday junction (HJ) was electrochemically switched between the open and closed (stacked) conformers. Switching was achieved by electrochemically induced quantitative release of Mg(2+) ions from the oxidised poly(N-methylpyrrole) film (PPy), which contained polyacrylate as an immobile counter anion and Mg(2+) ions as charge compensating mobile cations. This increase in the Mg(2+) concentration screened the electrostatic repulsion between the widely separated arms in the open HJ configuration, inducing switching to the closed conformation. Upon electrochemical reduction of PPy, entrapment of Mg(2+) ions back into the PPy film induced the reverse HJ switching from the closed to open state. The conformational transition was monitored using fluorescence resonance energy transfer (FRET) between donor and acceptor dyes each located at the terminus of one of the arms. The demonstrated electrochemical control of the conformation of the used probe-target HJ complex, previously reported as a highly sequence specific nanodevice for detecting of unlabelled target [Buck, A.H., Campbell, C.J., Dickinson, P., Mountford, C.P., Stoquert, H.C., Terry, J.G., Evans, S.A.G., Keane, L., Su, T.J., Mount, A.R., Walton, A.J., Beattie, J.S., Crain, J., Ghazal, P., 2007. Anal. Chem., 79, 4724-4728], allows the development of electronically addressable DNA nanodevices and label-free gene detection assays.

  5. The Timber Mountain magmato-thermal event: An intense widespread culmination of magmatic and hydrothermal activity at the southwestern Nevada volcanic field

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, Jr., Mac Roy [Univ. of Nevada, Reno, NV (United States)

    1988-05-01

    Eruption of the Rainier Mesa and Ammonia Tanks Members Timber Mountain Tuff at about 11.5 and 11.3 Ma, respectively, resulted in formation of the timber Mountain (TM) caldera; new K-Ar ages show that volcanism within and around the TM caldera continued for about 1 m.y. after collapse. Some TM age magmatic activity took place west and southeast of the TM caldera in the Beatty -- Bullfrog Hills and Shoshone Mountain areas, suggesting that volcanic activity at the TM caldera was an intense expression of an areally extensive magmatic system active from about 11.5 to 10Ma. Epithermal Au-Ag, Hg and fluorite mineralization and hydrothermal alteration are found in both within and surrounding the Timber Mountain -- Oasis Valley caldera complex. New K-Ar ages date this hydrothermal activity between about 13 and 10 Ma, largely between about 11.5 and 10 Ma, suggesting a genetic relation of hydrothermal activity to the TM magmatic system.

  6. Condensation heat transfer coefficients of flammable refrigerants on various enhanced tubes

    International Nuclear Information System (INIS)

    Park, Ki Jung; Jung, Dong Soo

    2005-01-01

    In this study, external condensation Heat Transfer Coefficients (HTCs) of six flammable refrigerants of propylene (R1270), propane (R290), isobutane (R600a), butane (R600), dimethylether (RE170), and HFC32 were measured at the vapor temperature of 39 .deg. C on a 1023 fpm low fin and turbo-C tubes. All data were taken under the heat flux of 32∼116 and 42∼142 kW/m 2 for the low fin and turbo-C tubes respectively. Flammable refrigerants' data obtained on enhanced tubes showed a typical trend that external condensation HTCs decrease with increasing wall subcooling. HFC32 and DME showed up to 30% higher HTCs than those of HCFC22 due to their excellent thermophysical properties. Propylene, propane, isobutane, and butane showed similar or lower HTCs than those of HCFC22. Beatty and Katz' correlation predicted the HTCs of the flammable refrigerants obtained on a low fin tube within a mean deviation of 7.3%. Turbo-C tube showed the best performance due to its 3 dimensional surface geometry for fast removal of condensate

  7. Low-level radioactive wastes. Council on Scientific Affairs

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    Under a federal law, each state by January 1, 1993, must provide for safe disposal of its low-level radioactive wastes. Most of the wastes are from using nuclear power to produce electricity, but 25% to 30% are from medical diagnosis, therapy, and research. Exposures to radioactivity from the wastes are much smaller than those from natural sources, and federal standards limit public exposure. Currently operating disposal facilities are in Beatty, Nev, Barnwell, SC, and Richland, Wash. National policy encourages the development of regional facilities. Planning a regional facility, selecting a site, and building, monitoring, and closing the facility will be a complex project lasting decades that involves legislation, public participation, local and state governments, financing, quality control, and surveillance. The facilities will utilize geological factors, structural designs, packaging, and other approaches to isolate the wastes. Those providing medical care can reduce wastes by storing them until they are less radioactive, substituting nonradioactive compounds, reducing volumes, and incinerating. Physicians have an important role in informing and advising the public and public officials about risks involved with the wastes and about effective methods of dealing with them. 18 references

  8. Low-level radioactive wastes. AMA Council on Scientific Affairs

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    Under a federal law, each state by January 1, 1993, must provide for safe disposal of its low-level radioactive wastes. Most of the wastes are from using nuclear power to produce electricity, but 25% to 30% are from medical diagnosis, therapy, and research. Exposures to radioactivity from the wastes are much smaller than those from natural sources, and federal standards limit public exposure. Currently operating disposal facilities are in Beatty, Nev, Barnwell, SC, and Richland, Wash. National policy encourages the development of regional facilities. Planning a regional facility, selecting a site, and building, monitoring, and closing the facility will be a complex project lasting decades that involves legislation, public participation, local and state governments, financing, quality control, and surveillance. The facilities will utilize geological factors, structural designs, packaging, and other approaches to isolate the wastes. Those providing medical care can reduce wastes by storing them until they are less radioactive, substituting nonradioactive compounds, reducing volumes, and incinerating. Physicians have an important role in informing and advising the public and public officials about risks involved with the wastes and about effective methods of dealing with them

  9. Southern Sierra Nevada Continental Dynamics Project: 1993 field observations of the NPE

    Energy Technology Data Exchange (ETDEWEB)

    Keller, G.R. [Univ. of Texas, El Paso, TX (United States); Malin, P.E. [Duke Univ., Durham, NC (United States); Ruppert, S.D. [LLNL, Livermore, CA (United States)

    1994-12-31

    The Southern Sierra Nevada Continental Dynamics Project is a multidisciplinary, multi-institutional investigation of the cause of the uplift of the Sierra Nevada and its relationship to extension in the adjacent Basin and Range. A broad range of geologic and geophysical data have been collected as part of this project. These data include both passive and active seismic measurements, as well as gravity and magnetotelluric observations. Three seismic refraction/wide-angle reflection profiles were recorded: (1) a 325-km-long, north-south profile extending from just east of Mono Lake south across the Garlock fault, (2) a 400-km-long, east-west profile extending from Death Valley west across the Sierra Nevada to near the San Andreas fault, and (3) a 480-km-long, east-west profile deployed for the NPE. This profile extended from Beatty, Nevada, west across the Sierra Nevada along the previously recorded east-west profile and continued nearly to the Pacific Ocean. Up to 675 seismic recorders were deployed for each profile. These data are allowing us to develop refined models of the crustal and upper mantle structure of the southern Sierra Nevada and to evaluate alternative hypotheses for its uplift and for Basin and Range extension. They also provide insight into the propagation of regional phases across complex structures.

  10. Microbial effects on radioactive wastes at SLB sites

    International Nuclear Information System (INIS)

    Colombo, P.

    1982-01-01

    The objectives of this study are to determine the significance of microbial degradation of organic wastes on radionuclide migration on shallow land burial for humid and arid sites, establish which mechanisms predominate and ascertain the conditions under which these mechanisms operate. Factors contolling gaseous eminations from low-level radioactive waste disposal sites are assessed. Importance of gaseous fluxes of methane, carbon dioxide and possibly hydrogen from the site stems from the inclusion of tritium and/or 14 C into the elemental composition of these compounds. In that the primary source of these gases is the biodegradation of organic components of the waste materials, primary emphasis of the study involved on examination of the biochemical pathways producing methane, carbon dioxide and hydrogen, and the environmental parameters controlling the activity of the microbial community involved. Although the methane and carbon dioxide production rate indicates the degradation rate of the organic substances in the waste, it does not predict the methane evolution rate from the trench site. Methane fluxes from the soil surface are equivalent to the net synthesis minus the quantity oxidized by the microbial community as the gas passes through the soil profile. Gas studies were performed at three commercial low-level radioactive waste disposal sites (West Valley, New York; Beatty, Nevada; Maxey Flats, Kentucky) during the period 1976 to 1978. The results of these studies are presented. 3 tables

  11. Geologic evaluation of the Oasis Valley basin, Nye County, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Fridrich, C.J.; Minor, S.A.; and Mankinen, E.A.

    2000-01-13

    This report documents the results of a geologic study of the area between the underground-nuclear-explosion testing areas on Pahute Mesa, in the northwesternmost part of the Nevada Test Site, and the springs in Oasis Valley, to the west of the Test Site. The new field data described in this report are also presented in a geologic map that is a companion product(Fridrich and others, 1999) and that covers nine 7.5-minute quadrangles centered on Thirsty Canyon SW, the quadrangle in which most of the Oasis Valley springs are located. At the beginning of this study, published detailed maps were available for 3 of the 9 quadrangles of the study area: namely Thirsty Canyon (O'Connor and others, 1966); Beatty (Maldonado and Hausback, 1990); and Thirsty Canyon SE (Lipman and others, 1966). Maps of the last two of these quadrangles, however, required extensive updating owing to recent advances in understanding of the regional structure and stratigraphy. The new map data are integrated in this re port with new geophysical data for the Oasis Valley area, include gravity, aeromagnetic, and paleomagnetic data (Grauch and others, 1997; written comm., 1999; Mankinen and others, 1999; Hildenbrand and others, 1999; Hudson and others, 1994; Hudson, unpub. data).

  12. Characteristics of wastes and soils which affect transport of radionuclides through the soil and their relationship to waste management. Annual report FY78

    International Nuclear Information System (INIS)

    Polzer, W.L.; Fowler, E.B.; Essington, E.H.

    1979-04-01

    Soil samples were collected from Beatty, NV, the University of California, Los Angeles/University of California, Berkeley (UCLA/UCB) project, California and Nebraska. Results of waste/soil interaction studies indicate that waste radionuclides can be categorized into three broad forms; filterable (insoluble) and sorbable and nonsorbable (soluble). The relative distribution of the three depends on the storage time of the waste and on the soil which is interacted with the waste. In the filterable (insoluble) fraction the radionuclides are associated with both organic and inorganic particulates. The primary inorganic particulate was identified as calcium carbonate. The soluble nonsorbable waste radionuclides possess a negative charge with the exception of 137 Cs; that species is positively charged. The presence of negatively charged species is attributed to complexing with either carbonate or chelating compounds. Changes in the soluble fraction of waste radionuclides on storage of waste are attributed in part to the dissolution or precipitation of calcium carbonate and perhaps the degradation of organic material or growth of microorganisms in the waste. 11 figures, 31 tables

  13. Can taking the perspective of an expert debias human decisions? The case of risky and delayed gains.

    Science.gov (United States)

    Białek, Michał; Sawicki, Przemysław

    2014-01-01

    In several previously reported studies, participants increased their normative correctness after being instructed to think hypothetically, specifically taking the perspective of an expert or researcher (Beatty and Thompson, 2012; Morsanyi and Handley, 2012). The goal of this paper was to investigate how this manipulation affects risky or delayed payoffs. In two studies, participants (n = 193) were tested online (in exchange for money) using the adjusting procedure. Individuals produced certain/immediate equivalents for risky/delayed gains. Participants in the control group were solving the problem from their own perspective, while participants in the experimental group were asked to imagine "what would a reliable and honest advisor advise them to do." Study 1 showed that when taking the perspective of an expert, participants in experimental group became more risk aversive compared to participants in the control group. Additionally, their certain equivalents diverged from the expected value to a greater extent. The results obtained from the experimental group in Study 2 suggest that participants became less impulsive, which means they tried to inhibit their preferences. This favors the explanation, which suggests that the perspective shift forced individuals to override their intuitions with the social norms. Individuals expect to be blamed for impatience or risk taking thus expected an expert to advise them to be more patient and risk aversive.

  14. Repeat biopsy in patients with initial diagnosis of PIN; La biopsia ripetuta nei pazienti con diagnosi iniziale di PIN

    Energy Technology Data Exchange (ETDEWEB)

    De Matteis, Massimo [Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna (Italy). UO Radiologia Albertoni; Poggi, Cristina; De Martino, Antonietta; Pavlica, Pietro [Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna (Italy). UO Radiologia Palagi, Dipartimento area radiologica; Corti, Barbara [Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna (Italy). UO Anatomia ed istologia patologica, Dipartimento oncologico ed ematologico; Barozzi, Libero [Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna (Italy). UO Radiologia d' urgenza, Dipartimento emergenze ed accettazione

    2005-09-15

    indirizzare i pazienti alla biopsia ripetuta. Materiale e metodi. Abbiamo valutato i risultati di 72 biopsie ripetute in pazienti con una diagnosi di PIN ad una prima agobiopsia prostatica ecoguidata. A tutti e stato effettuato un numero minimo di 6 prelievi. Tutti avevano un PSA>4 ng/ml. Risultati. Sono stati rilevati alla biopsia ripetuta 15 adenocarcinomi su 50 pazienti (30%) con diagnosi iniziale di PIN a basso grado e 10 carcinomi su 22 (45,4%) con PIN ad alto grado. Sono stati diagnosticati 7 carcinomi in 18 pazienti (39%) nei quali il PSA era diminuito durante l'intervallo di osservazione, in 16 su 46 (35%) nei quali il PSA in aumento e 2 su 8 casi (25%) con PSA stabile. Conclusioni. I risultati sembrano confermare che il PIN puo essere considerato un precursore dell'adenocarcinoma prostatico o un'alterazione istologica frequentemente associata ad esso. I pazienti con diagnosi iniziale di PIN a basso grado e soprattutto quelli con PIN ad alto grado dovrebbero sistematicamente essere sottoposti a biopsia ripetuta a breve distanza per l'elevata frequenza di diagnosi finale di carcinoma. Non esistono ancora indicazioni condivise sull'intervallo temporale tra le due biopsie. Le variazioni del PSA che si possono riscontrare durante il periodo di osservazione non rappresentano un parametro statisticamente significativo per proporre o meno al paziente la ripetizione della biopsia prostatica.

  15. Railway traffic noise pollution. Source, propagation and abatement systems; L'inquinamento acustico prodotto da traffico ferroviario. Origine, propagazione e sistemi di attenuazione. Progetto Apparati silenti

    Energy Technology Data Exchange (ETDEWEB)

    Lanchi, M.; Salernitano, E. [ENEA, Div. Nuovi Materiali, Centro Ricerche Casaccia, Rome (Italy)

    2001-07-01

    specifico alla Legge Quadro n. 447 del 26/10/95 e al D.P.R. n. 459 del 18/11/98. Vengono poi trattati, da un punto di vista fenomenologico e di modellizzazione, i meccanismi di generazione e di propagazione del rumore, con particolare riferimento al processo di attenuazione del livello sonoro, ad opera di dispositivi naturali o artificiali. Lo studio di quest'ultimo aspetto rappresenta la parte centrale del presente lavoro: sono state esaminate diverse configurazioni di barriere antirumore artificiali, riportando i risultati sia di sperimentazioni condotte in situ, sia di simulazioni avanzate. Le prestazioni di diverse soluzioni schermanti, caratterizzate da geometrie e materiali differenti, sono state messe a confronto in base a parametri tecnici, economici e di fattibilita'. Infine sulla base delle attuali tecnologie, viene proposta una soluzione progettuale innovativa per la realizzazione di un sistema antirumore efficace e a basso impatto visivo. Essa e' costituita da una barriera fissa, adiacente ai binari e realizzata in plastica riciclata, e da uno schermo mobile, solidale al vagone, in materiale composito. Secondo i criteri di confronto sopra esposti, tale soluzione sembra rispondere alle esigenze di riduzione del fonoinquinamento, basso impatto ambientale e costi contenuti.

  16. Politica bancaria e sviluppo economico: rileggendo l'era menichelliana e quella attuale (Banking policy and economic development: re-reading the menichellian era and the present

    Directory of Open Access Journals (Sweden)

    Mario Sarcinelli

    2012-04-01

    Full Text Available Il basso tasso di crescita dell’Italia, anche nel contesto internazionale ed europeo, ha spinto a confrontare gli anni ’50 con gli ultimi dieci o quindici. Dall’analisi emerge che, se si esclude l’iniziale liberalizzazione del commercio internazionale, il periodo che vide la più vigorosa crescita dell’Italia fu caratterizzato dall’economia mista, da monopoli pubblici e posizioni private dominanti, da una politica monetaria e bancaria basata su controlli diretti ed esercizi di persuasione morale individuale, tutte condizioni oggi ritenute sfavorevoli alla crescita. Al contrario, nella fase attuale l’enfasi è stata sul modello di economia liberale, con liberalizzazioni, privatizzazioni di imprese produttive e di banche, politiche incentrate sugli incentivi e sul mercato. Purtroppo, la scienza economica non ha ancora trovato il paradigma generale che spiega la ricchezza delle nazioni a prescindere dal contesto e dagli uomini che lo animano.  The low growth rate of Italy, also in international and European context, has led to compare the 50s with the last ten or fifteen. The analysis shows that, apart from the initial liberalization of international trade, the period that saw the most vigorous growth in Italy was characterized from a mixed economy, with public monopolies and dominant positions private, from a monetary and banking policy based of direct controls and exercises of individual moral suasion, all conditions previously deemed unfavorable to growth. On the contrary, at this stage the emphasis was on the model of liberal economy, with liberalization, privatization of productive enterprises and banks, policies based on incentives and market. Unfortunately, the economic science has not yet found a general paradigm that explains the wealth of nations regardless of the context and the men who animate it. JEL Codes: B31, E65, N14, O10Keywords: tasso di crescita, commercio internazionale, politica monetaria, politica bancaria

  17. Transplanted Peripheral Blood Stem Cells Mobilized by Granulocyte Colony-Stimulating Factor Promoted Hindlimb Functional Recovery After Spinal Cord Injury in Mice.

    Science.gov (United States)

    Takahashi, Hiroshi; Koda, Masao; Hashimoto, Masayuki; Furuya, Takeo; Sakuma, Tsuyoshi; Kato, Kei; Okawa, Akihiko; Inada, Taigo; Kamiya, Koshiro; Ota, Mitsutoshi; Maki, Satoshi; Takahashi, Kazuhisa; Yamazaki, Masashi; Mannoji, Chikato

    2016-01-01

    Granulocyte colony-stimulating factor (G-CSF) mobilizes peripheral blood stem cells (PBSCs) derived from bone marrow. We hypothesized that intraspinal transplantation of PBSCs mobilized by G-CSF could promote functional recovery after spinal cord injury. Spinal cords of adult nonobese diabetes/severe immunodeficiency mice were injured using an Infinite Horizon impactor (60 kdyn). One week after the injury, 3.0 µl of G-CSF-mobilized human mononuclear cells (MNCs; 0.5 × 10(5)/µl), G-CSF-mobilized human CD34-positive PBSCs (CD34; 0.5 × 10(5)/µl), or normal saline was injected to the lesion epicenter. We performed immunohistochemistry. Locomotor recovery was assessed by Basso Mouse Scale. The number of transplanted human cells decreased according to the time course. The CD31-positive area was significantly larger in the MNC and CD34 groups compared with the vehicle group. The number of serotonin-positive fibers was significantly larger in the MNC and CD34 groups than in the vehicle group. Immunohistochemistry revealed that the number of apoptotic oligodendrocytes was significantly smaller in cell-transplanted groups, and the areas of demyelination in the MNC- and CD34-transplanted mice were smaller than that in the vehicle group, indicating that cell transplantation suppressed oligodendrocyte apoptosis and demyelination. Both the MNC and CD34 groups showed significantly better hindlimb functional recovery compared with the vehicle group. There was no significant difference between the two types of transplanted cells. Intraspinal transplantation of G-CSF-mobilized MNCs or CD34-positive cells promoted angiogenesis, serotonergic fiber regeneration/sparing, and preservation of myelin, resulting in improved hindlimb function after spinal cord injury in comparison with vehicle-treated control mice. Transplantation of G-CSF-mobilized PBSCs has advantages for treatment of spinal cord injury in the ethical and immunological viewpoints, although further exploration

  18. Book review, Ominis e bestias in su campidanu de iossu, Marcello Furio Pili

    Directory of Open Access Journals (Sweden)

    Manuel Graziani

    2011-12-01

    Full Text Available Ciò che ci ha più incuriosito di questa pubblicazione è il sottotitolo “Il rapporto tra uomini e animali nelle attività lavorative del passato e del presente”. L’autore Marcello Furio Pili, pur riconoscendo una sorta di omologazione della società umana a seguito della rivoluzione industriale, parte dal presupposto storico dell’unicità del rapporto con gli animali che da sempre è un tratto distintivo del popolo sardo. La ricerca si concentra su cinque paesi del Basso Campidano: Nuraminis, Monastir, Ussana, San Sperate e Sestu, ognuno trattato in una veste monografica a sé stante ma con la medesima struttura editoriale e contenutistica. Cinque paesi di stampo rurale la cui economia, almeno fino ai primi decenni del ’900, “era fondata essenzialmente sull’utilizzo della terra, agricoltura e allevamento di bestiame quindi, e quasi ogni altra attività ruotava intorno alla sfera del rus, della campagna”. Grande spazio viene dedicato, infatti, agli animali (bovini, equini, caprini, suidi, canidi, felini, leporidi, roditori, uccelli, insetti, ecc. che vengono classificati secondo la tassonomia risalente al Sistema della Natura di Linneo, con ovini e caprini accorpati in un unico paragrafo seguendo la moderna classificazione che li inserisce entrambi nella sottofamiglia Caprinae.Il grande formato del libro (21 × 29 cm e la presenza di numerose foto di animali, vegetazione e, soprattutto, vecchi strumenti di lavoro, rendono ancor più interessante questa ricerca che, pur essendo sostanzialmente di carattere antropologico, culturale e linguistico, è molto centrata sul rapporto uomo-animale: “Il rapporto con gli animali, in un modo o nell’altro, era, per quasi tutti i componenti della comunità, costante, necessario, inevitabile.”.

  19. L'integrazione delle pratiche di Sanitá Pubblica in Europa

    Directory of Open Access Journals (Sweden)

    H. Waller

    2003-05-01

    Full Text Available

    Rilevanza dell’argomento: questo tema è diventato un importante problema di Sanità Pubblica anche in Europa. Studi epidemiologici mostrano che quasi tutti i problemi di salute e la prevalenza di malattie e di disabilità sono più frequenti negli strati sociali più bassi, indipendentemente dal modo in cui la classe sociale viene misurata (con qualche eccezione come ad esempio il cancro della mammella e le allergie. Inoltre, l’associazione tra svantaggio sociale e malattia è divenuta sempre più forte negli ultimi decenni (Marmot e Wilkinson, 1999.

     La rilevanza del tema è diventata ancora più grande dal momento che in molti Paesi candidati all’ingresso nell’Unione Europea sono frequenti povertà e disgregazione sociale (Mackenbach e Bakker, 2002. Future necessita’ di ricerca: in futuro, tutte le indagini nazionali sulla salute dovranno includere la classe sociale tra le variabili registrate regolarmente. La ricerca dovrà infatti concentrarsi sulla spiegazione della correlazione tra classe sociale e malattia usando studi longitudinali ed includendo fattori sociali, oltre a determinanti medico-sanitari.

    La correlazione tra classe sociale e la presenza di problemi di salute va studiata in entrambe le direzioni: un basso status sociale come determinante di malattia, come pure la presenza di problemi di salute come causa della discesa nella “scala sociale”. La pratica di Sanità Pubblica e lo sviluppo di politiche sociali devono affrontare adeguatamente entrambe le ipotesi.

  20. Apolipoprotein E Mimetic Promotes Functional and Histological Recovery in Lysolecithin-Induced Spinal Cord Demyelination in Mice.

    Science.gov (United States)

    Gu, Zhen; Li, Fengqiao; Zhang, Yi Ping; Shields, Lisa B E; Hu, Xiaoling; Zheng, Yiyan; Yu, Panpan; Zhang, Yongjie; Cai, Jun; Vitek, Michael P; Shields, Christopher B

    2013-04-01

    Considering demyelination is the pathological hallmark of multiple sclerosis (MS), reducing demyelination and/or promoting remyelination is a practical therapeutic strategy to improve functional recovery for MS. An apolipoprotein E (apoE)-mimetic peptide COG112 has previously demonstrated therapeutic efficacy on functional and histological recovery in a mouse experimental autoimmune encephalomyelitis (EAE) model of human MS. In the current study, we further investigated whether COG112 promotes remyelination and improves functional recovery in lysolecithin induced focal demyelination in the white matter of spinal cord in mice. A focal demyelination model was created by stereotaxically injecting lysolecithin into the bilateral ventrolateral funiculus (VLF) of T8 and T9 mouse spinal cords. Immediately after lysolecithin injection mice were treated with COG112, prefix peptide control or vehicle control for 21 days. The locomotor function of the mice was measured by the beam walking test and Basso Mouse Scale (BMS) assessment. The nerve transmission of the VLF of mice was assessed in vivo by transcranial magnetic motor evoked potentials (tcMMEPs). The histological changes were also examined by by eriochrome cyanine staining, immunohistochemistry staining and electron microscopy (EM) method. The area of demyelination in the spinal cord was significantly reduced in the COG112 group. EM examination showed that treatment with COG112 increased the thickness of myelin sheaths and the numbers of surviving axons in the lesion epicenter. Locomotor function was improved in COG112 treated animals when measured by the beam walking test and BMS assessment compared to controls. TcMMEPs also demonstrated the COG112-mediated enhancement of amplitude of evoked responses. The apoE-mimetic COG112 demonstrates a favorable combination of activities in suppressing inflammatory response, mitigating demyelination and in promoting remyelination and associated functional recovery in animal model

  1. Precopulatory sexual behavior of male mice is changed by the exposure to tannery effluent.

    Science.gov (United States)

    Quintão, Thales Chagas; Rabelo, Letícia Martins; Alvarez, T G S; Guimarães, A T; Rodrigues, A S L; Cardoso, L S; Ferreira, R O; Malafaia, Guilherme

    2018-03-01

    Although the toxic potential of tannery effluents (TE) is acknowledged, the impacts these residues have on mammals who intake water contaminated with this pollutant are not completely known. Thus, in order to broaden the knowledge about how these contaminants affect the biota, the aim of the current study is to assess different behavioral categories (e.g.: sexual odor preference, opposite-sex attraction, and sexual discrimination) related to the sexual motivation and pre-copulation of male Swiss mice subjected to TE intake for 30 days, at concentrations 0.8% and 22%. The animals were subjected to locomotor performance evaluation through the Basso Mouse Scale (BMS), as well as to the open field (OF), odor preference (OPT), sexual orientation (SOT) and to scent marking tests (SMT) one week before the experiment ended. Our results evidenced that the treatments did not affect the animals' locomotor activity (in OF and BMS) or caused changes compatible to anxiogenic or anxiolytic behavior (in OF). However, mice exposed to TE (at both concentrations) presented discriminatory capacity deficit in the OPT test at the time to distinguish conspecific odors from the same sex, and from the opposite sex. They randomly explored (without preference) males and females, did not responded to stimuli in the SOT test, as well as did not appear capable of detecting female odor (in estrus phase) during the SMT. Thus, the current study was pioneer in evidencing that TE can influence the reproduction and the population dynamics of small rodents who intake water contaminated with the pollutant. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Alternative disinfectant in drinking water systems. The peracetic acid; Disinfettanti alternativi in potabilizzazione. L`acido peracetico

    Energy Technology Data Exchange (ETDEWEB)

    Ragazzo, Patrizia; Navazio, Giancarlo [Padua, Univ. (Italy). Fac. di Ingegneria. Dipt. dei Processi Chimici dell`Ingegneria; Cavadore, Alberto [Solvay Interox, Rosignano (Italy); Babato, Ferdinando [Consorzio per l`Acquedotto del Basso Piave, S. Dona` di Piave (Italy)

    1997-03-01

    The need to use oxidation techniques in mains water systems, especially when treating surface water, has brought about a greater awareness as to the health risks associated to the presence of residual chemical compounds or disinfection by-products (DBP), which are commonly found in water supplies treated by means of traditional disinfectants (i.e. Cl{sub 2}, ClO{sub 2}, NH{sub 2}Cl, O{sub 3}, etc.). As a consequence, legislative standards have had to define greater restrictions regarding their use. In the light of this situation, the authors have set out to examine the feasibility of employing peracetic acid (PAA), which features low production of DBPs, as an alternative disinfectant. Preliminary experimental tests have been carried out on water samples taken from several process points within a water treatment plant at the Basso Piave mains water system, located in Jesolo, near Venice in Italy. These samples were treated with batch PAA doses ranging from 1 to 5 ppm for a variety of different exposition periods, also with varying temperature, pH and water properties. These experiments made it possible to asses the decay kinetics of PAA as well as reduction of characteristic microbiological parameters in raw and treated incoming and outgoing water throughout the various stages of the treatment process. The results achieved during these tests appear to provide ample evidence regarding the possibilities of use for PAA (with medium dosage of 1.5 to 2 ppm, contact times from 30` to 60` and abatement up to 95 %), after having assessed its compatibility, especially in order to the increase of the assimilable organic carbon, with the characteristics of the plant and distribution network, by continuous reactors and pilot plants.

  3. Mesola red deer: physical characteristics, population dynamics and conservation perspectives

    Directory of Open Access Journals (Sweden)

    Stefano Mattioli

    2003-10-01

    Full Text Available Abstract The biometry, demography and genetics of red deer Cervus elaphus of Mesola Wood (NE Italy, are presented and discussed in relation to the conservation of this population. Modest body size, low stature, oversimplified antlers and a low reproductive performance characterise red deer from Mesola Wood. The mitochondrial genome showed a private haplotype, different from other red deer in Italy and central Europe. The uniqueness of this nucleus and its biogeographic importance make a long-term conservation plan particularly urgent. Management measures such as fallow deer reduction, winter feeding and pasture mowing were tested, giving promising results. The physical condition of the animals improved, calf and adult mortality declined, and a few cases of antlers with bez tine or crown were reported in this study after four decades. Riassunto Il Cervo della Mesola: caratteristiche fisiche, dinamica di popolazione e prospettive di conservazione La biometria, la demografia e la genetica del cervo Cervus elaphus del Gran Bosco della Mesola (Italia nord-orientale, vengono presentate e discusse in relazione alla salvaguardia di questa popolazione. Il cervo della Mesola risulta caratterizzato dalle modeste dimensioni corporee, dalla struttura semplificata dei palchi e da un basso rendimento riproduttivo. L'analisi del genoma mitocondriale ha evidenziato un aplotipo privato, diverso da quello degli altri cervi italiani e centroeuropei. L'unicità di questo nucleo e la sua importanza biogeografica rendono particolarmente urgente un piano di conservazione a lungo termine. Sono stati verificati interventi gestionali quali la riduzione numerica dei daini, il foraggiamento invernale e lo sfalcio delle superfici a pascolo, con risultati promettenti. Le condizioni fisiche degli animali sono migliorate, la mortalità tra i piccoli e gli adulti è diminuita, e sono stati registrati alcuni

  4. Occupare spazi, liberare luoghi della mente e della cittadinanza: esperienze di riappropriazione a Roma

    Directory of Open Access Journals (Sweden)

    Irene Ranaldi

    2014-11-01

    Full Text Available Negli ultimi anni l’utilizzo degli spazi pubblici e abitativi è diventato una delle sfide più significative per le amministrazioni locali che si trovano a dover mediare tra gli interessi di soggetti pubblici e privati, associazioni e residenti per migliorare la qualità dei luoghi di vita urbani. Amministratori locali, urbanisti e organizzatori di comunità sono alcuni degli attori di queste nuove forme di cambiamento urbano che emergono dal basso, grazie ad un confronto costante con le esigenze del territorio che spinge ad una rimodulazione di spazi e strutture pubbliche ridando così nuova vita ad interi pezzi di città, spesso abbandonati o dismessi o in annosa attesa di recupero. Esperienze di questo tipo di ri-appropriazione, sia esso con la pratica dell’occupazione o dell’esito di un processo di progettazione partecipata tra cittadini e istituzioni, si susseguono sempre più spesso in Europa e negli Stati Uniti. Come può definirsi uno spazio pubblico? Può essere definito come ogni luogo di proprietà pubblica o di uso pubblico accessibile e fruibile a tutti gratuitamente e senza scopi di lucro. Gli spazi pubblici rappresentano i luoghi della vita collettiva delle comunità e un elemento decisivo per il benessere individuale e sociale in quanto dotati di specifiche caratteristiche spaziali, storiche, ambientali, sociali ed economiche. Lo spazio è una condizione perché le modalità spaziali di esperienza in qualche modo indirizzano il configurarsi delle forme sociali, ma assume un significato sociologico in quanto simbolo della relazione sociale. Riappropriarsi in qualche modo di questo simbolo, declinandone gli esiti in forme differenti di partecipazione, può significare liberare luoghi della mente e dell’espressività.

  5. Effect of lycopene on the blood-spinal cord barrier after spinal cord injury in mice.

    Science.gov (United States)

    Zhang, Qian; Wang, Jianbo; Gu, Zhengsong; Zhang, Qing; Zheng, Hong

    2016-09-05

    The current study aimed to investigate the effect of lycopene on the blood-spinal cord barrier (BSCB) after spinal cord injury (SCI) in a mouse model. Lycopene inhibited lipid peroxidation and oxidative DNA damage as a highly efficient antioxidant and free radical scavenger. Lycopene (4 mg/kg/d) was administrated immediately following SCI. The permeability of the BSCB and water content in the spinal cord tissue were evaluated. Additionally, levels of expression of tight junction proteins and heme oxygenase-1 (HO-1) were determined with Western blotting. An enzyme-linked immunosorbent assay analysis of spinal cord tissue homogenates was performed 48 h after SCI to evaluate the expression of inflammation-related cytokines. In addition, recovery of motor function was assessed 1 d, 2 d, 5 d, 10 d, and 15 d after SCI using the Basso Mouse Scale to score locomotion. Compared to the group with an untreated SCI, mice with an SCI treated with lycopene had significantly reduced spinal cord tissue water content and BSCB permeability. Furthermore, motor function of mice with an SCI was also greatly improved by lycopene administration. The expression of the proinflammatory factors TNF-α and NF-kB increased markedly 48 h after SCI, and their upregulation was significantly attenuated by lycopene treatment. The expression of molecules that protect tight junctions, zonula occluden-1 and claudin-5, was upregulated by lycopene treatment after SCI. Taken together, these results clearly indicate that lycopene attenuated SCI by promoting repair of the damaged BSCB, so lycopene is a novel and promising treatment for SCI in humans.

  6. Does vitamin C have the ability to augment the therapeutic effect of bone marrow-derived mesenchymal stem cells on spinal cord injury?

    Directory of Open Access Journals (Sweden)

    Nesrine Salem

    2017-01-01

    Full Text Available Methylprednisolone (MP is currently the only drug confirmed to exhibit a neuroprotective effect on acute spinal cord injury (SCI. Vitamin C (VC is a natural water-soluble antioxidant that exerts neuroprotective effects through eliminating free radical damage to nerve cells. Bone marrow mesenchymal stem cells (BMMSCs, as multipotent stem cells, are promising candidates in SCI repair. To evaluate the therapeutic effects of MP, VC and BMMSCs on traumatic SCI, 80 adult male rats were randomly divided into seven groups: control, SCI (SCI induction by weight-drop method, MP (SCI induction, followed by administration of 30 mg/kg MP via the tail vein, once every other 6 hours, for five times, VC (SCI induction, followed by intraperitoneal administration of 100 mg/kg VC once a day, for 28 days, MP + VC (SCI induction, followed by administration of MP and VC as the former, BMMSCs (SCI induction, followed by injection of 3 × 106 BMMSCs at the injury site, and BMMSCs + VC (SCI induction, followed by BMMSCs injection and VC administration as the former. Locomotor recovery was assessed using the Basso Mouse Scale. Injured spinal cord tissue was evaluated using hematoxylin-eosin staining and immunohistochemical staining. Expression of transforming growth factor-beta, tumor necrosis factor-alpha, and matrix metalloproteinase-2 genes was determined using real-time quantitative PCR. BMMSCs intervention better promoted recovery of nerve function of rats with SCI, mitigated nerve cell damage, and decreased expression of transforming growth factor-beta, tumor necrosis factor-alpha, and matrix metalloproteinase-2 genes than MP and/or VC. More importantly, BMMSCs in combination with VC induced more obvious improvements. These results suggest that VC can enhance the neuroprotective effects of BMMSCs against SCI.

  7. Italian neuropsychology in the second half of the twentieth century.

    Science.gov (United States)

    Vallar, Giuseppe; Boller, François; Grossi, Dario; Gainotti, Guido

    2015-03-01

    Since the early 1960s, human neuropsychology, the study of brain-behavior interrelations, mainly based on the analysis of their pathological variations, brought about by brain damage, has had a remarkable systematical development in Italy. All this started in Milan, with the neurologist Ennio de Renzi, and his collaborators (Luigi Vignolo, then Anna Basso, Pietro Faglioni, Hans Spinnler, François Boller, and, more autonomously, Edoardo Bisiach), in the Clinic of Nervous and Mental Diseases. Scientists of the "Milan group" investigated several neuropsychological deficits caused by focal hemispheric lesions in large series of left- and right-brain-damaged patients, and control participants, comparable for cultural and demographic variables. Standardized tests and advanced statistical methods were used, which also applied to the diagnosis and rehabilitation of aphasia. Subsequently, neuropsychology developed in Italy extensively, reaching high international reputation. Leading neuropsychologists have been the neurologists Guido Gainotti (Rome), and Franco Denes (Padua), the physicians and psychologists Luigi Pizzamiglio (Rome), and Carlo Umiltà (Parma, with fruitful interactions with the neurophysiologists Giovanni Berlucchi, Giacomo Rizzolatti, and Carlo Marzi, from the school of Giuseppe Moruzzi in Pisa) A second scientific generation of neuropsychologists has then developed in the 1970s, trained by the abovementioned scientists, further boosting and spreading high-level basic and applied research (diagnosis and rehabilitation of neuropsychological deficits of patients with brain damage or dysfunction throughout the life span, from childhood to the elderly). Available techniques include structural and functional imaging (CT, PET, SPET, MRI and fMRI Scans, DTI), electrophysiological recording (EEG, ERPs), non-invasive brain stimulation (TMS, tES), and their combined use.

  8. Intermittent fasting in mice does not improve hindlimb motor performance after spinal cord injury.

    Science.gov (United States)

    Streijger, Femke; Plunet, Ward T; Plemel, Jason Ryan; Lam, Clarrie K; Liu, Jie; Tetzlaff, Wolfram

    2011-06-01

    Previously, we reported that every-other-day-fasting (EODF) in Sprague-Dawley rats initiated after cervical spinal cord injury (SCI) effectively promoted functional recovery, reduced lesion size, and enhanced sprouting of the corticospinal tract. More recently, we also showed improved behavioral recovery with EODF after a moderate thoracic contusion injury in rats. In order to make use of transgenic mouse models to study molecular mechanisms of EODF, we tested here whether this intermittent fasting regimen was also beneficial in mice after SCI. Starting after SCI, C57BL/6 mice were fed a standard rodent chow diet either with unrestricted access or feeding every other day. Over a 14-week post-injury period, we assessed hindlimb locomotor function with the Basso Mouse Scale (BMS) open-field test and horizontal ladder, and the spinal cords were evaluated histologically to measure white and grey matter sparing. EODF resulted in an overall caloric restriction of 20% compared to animals fed ad libitum (AL). The EODF-treated animals exhibited a ∼ 14% reduction in body weight compared to AL mice, and never recovered to their pre-operative body weight. In contrast to rats on an intermittent fasting regimen, mice exhibited no increase in blood ketone bodies by the end of the second, third, and fourth day of fasting. EODF had no beneficial effect on tissue sparing and failed to improve behavioral recovery of hindlimb function. Hence this observation stands in stark contrast to our earlier observations in Sprague-Dawley rats. This is likely due to the difference in the metabolic response to intermittent fasting as evidenced by different ketone levels during the first week of the EODF regimen.

  9. Test facilities for hybrid and electric drive trains; Stazione di prova sistemi di trazione ibridi ed elettrici

    Energy Technology Data Exchange (ETDEWEB)

    Bernardini, G.; Ciancia, A.; De Andreis, L.; Pagni, G.; Pede, G.; Rossi, E.; Vellone, R. [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dip. Energia

    1998-12-31

    ENEA (Italian National Agency for New Technologies, Energy and the Environment) is conducting a large research and development programme on innovative vehicles with high energy efficiency and low environmental impact. In particular conducts activities on electric and hybrid vehicles. Testing and evaluation activities play a strong role in this programme. A complete characterization chain has been then defined and set up with a network of facilities which covers main testing needs for single components, subsystems and complete vehicles, in simulated and real operating conditions. The test facility which has been realised is able to experiment and fully characterise complete drive-trains (and subsystems) for pure electric and hybrid vehicles. It is composed by a different section for each subsystem: 1) power generation; 2) energy storage and management; 3) driving motors. Each section acts as an experimental island, able to operate alone or jointly with the other sections. In fact, all the sections are remotely controlled and managed in order to create different assembly of the drive-train. The facility has been sized to allow the testing of drive-trains and subsystems of small and medium-sized vehicles (up to minibuses), but an extension to larger vehicles is possible. During 1996 and part of 1997 the Drive train Test Facility has been completed and made operative. This paper mainly presents the final configurations of these novel testing systems with peculiar features and characteristics. [Italiano] ENEA (Ente Nazionale per le nuove tecnologie, l`Energia e l`Ambiente) sta conducendo un vasto programma di ricerca e sviluppo sui veicoli innovativi ad alto rendimento energetico e basso impatto ambientale.

  10. The AgMIP Wheat Pilot: A multi-model approach for climate change impact assessments.

    Science.gov (United States)

    Asseng, S.

    2012-12-01

    Asseng S., F. Ewert, C. Rosenzweig, J.W. Jones, J.L. Hatfield, A. Ruane, K.J. Boote, P. Thorburn, R.P. Rötter, D. Cammarano, N. Brisson, B. Basso, P. Martre, D. Ripoche, P. Bertuzzi, P. Steduto, L. Heng, M.A. Semenov, P. Stratonovitch, C. Stockle, G. O'Leary, P.K. Aggarwal, S. Naresh Kumar, C. Izaurralde, J.W. White, L.A. Hunt, R. Grant, K.C. Kersebaum, T. Palosuo, J. Hooker, T. Osborne, J. Wolf, I. Supit, J.E. Olesen, J. Doltra, C. Nendel, S. Gayler, J. Ingwersen, E. Priesack, T. Streck, F. Tao, C. Müller, K. Waha, R. Goldberg, C. Angulo, I. Shcherbak, C. Biernath, D. Wallach, M. Travasso, A. Challinor. Abstract: Crop simulation models have been used to assess the impact of climate change on agriculture. These assessments are often carried out with a single model in a limited number of environments and without determining the uncertainty of simulated impacts. There is a need for a coordinated effort bringing together multiple modeling teams which has been recognized by the Agricultural Model Intercomparison and Improvement Project (AgMIP; www.agmip.org). AgMIP aims to provide more robust estimates of climate impacts on crop yields and agricultural trade, including estimates of associated uncertainties. Here, we present the AgMIP Wheat Pilot Study, the most comprehensive model intercomparison of the response of wheat crops to climate change to date, including 27 wheat models. Crop model uncertainties in assessing climate change impacts are explored and compared with field experimental and Global Circulation Model uncertainties. Causes of impact uncertainties and ways to reduce these are discussed.

  11. I mutamenti tecnologici nelle condizioni odierne: riflessioni di un economista. (Technological changes in present-day conditions: reflections of an economist

    Directory of Open Access Journals (Sweden)

    P. SYLOS LABINI

    2013-12-01

    Full Text Available Tutti gli economisti concordano sul fatto che i cambiamenti tecnologici costituiscono la principale fonte di sviluppo economico . Tuttavia , molti economisti sono convinti che tali cambiamenti sono importanti solo per spinegre verso l'alto il tasso di sviluppo economico, che a lungo andare sarebbe altrimenti più basso e costante , con l'accumulazione di capitale e forza lavoro di crescita in atto gradualmente . Al contrario , il presente lavoro sostiene che nel lungo periodo , il progresso tecnico non è il fattore principale dello sviluppo economico , ma piuttosto una condizione necessaria . L'autore esamina l'evoluzione tecnologica nella teoria economica e la storia dello sviluppo economico . La disoccupazione tecnologica e la disoccupazione keynesiana sono quindi analizzate , così come la riduzione dell'orario di lavoro . Infine , l'autore considera più recenti sviluppi tecnologici ed economici e la loro relazione con il lavoro manuale e intellettuale .All economists agree that technological changes constitute the main source of economic development. Nonetheless, many economists are convinced that such changes are important only in pushing up the rate of economic development, which in the long run would otherwise be lower and constant, with capital accumulation and labor force growth taking place gradually. To the contrary, the present work argues that in the long run, technical progress is not the main factor of economic development, but rather a necessary condition. The author examines technological change in economic theory and the history of economic development. Technological unemployment and Keynesian unemployment are then considered as well as the reduction of working hours. Finally, the author considers more recent technological and economic developments and their relation to manual and intellectual labour.JEL: O33, E24

  12. Hexagon functions and the three-loop remainder function

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, Lance J.; Drummond, James M.; von Hippel, Matt; Pennington, Jeffrey

    2013-12-01

    We present the three-loop remainder function, which describes the scattering of six gluons in the maximally-helicity-violating configuration in planar NN = 4 super-Yang-Mills theory, as a function of the three dual conformal cross ratios. The result can be expressed in terms of multiple Goncharov polylogarithms. We also employ a more restricted class of hexagon functions which have the correct branch cuts and certain other restrictions on their symbols. We classify all the hexagon functions through transcendental weight five, using the coproduct for their Hopf algebra iteratively, which amounts to a set of first-order differential equations. The three-loop remainder function is a particular weight-six hexagon function, whose symbol was determined previously. The differential equations can be integrated numerically for generic values of the cross ratios, or analytically in certain kinematic limits, including the near-collinear and multi-Regge limits. These limits allow us to impose constraints from the operator product expansion and multi-Regge factorization directly at the function level, and thereby to fix uniquely a set of Riemann ζ valued constants that could not be fixed at the level of the symbol. The near-collinear limits agree precisely with recent predictions by Basso, Sever and Vieira based on integrability. The multi-Regge limits agree with the factorization formula of Fadin and Lipatov, and determine three constants entering the impact factor at this order. We plot the three-loop remainder function for various slices of the Euclidean region of positive cross ratios, and compare it to the two-loop one. For large ranges of the cross ratios, the ratio of the three-loop to the two-loop remainder function is relatively constant, and close to -7.

  13. Neuroscience Knowledge Among Athletic Training Professional Programs

    Directory of Open Access Journals (Sweden)

    Douglas M. Seavey

    2016-05-01

    Full Text Available The Journal of Sports Medicine & Allied Health Sciences, 2016;2(1 ISSN: 2376-9289 Seavey, Beatty, Lenhoff, & Krause. Neuroscience Knowledge Among Athletic Training Professional Programs Neuroscience Knowledge Among Athletic Training Professional Programs Douglas M. Seavey, AT, Christopher T. Beatty, Tyler L. Lenhoff, & Bentley A. Krause, PhD, AT Ohio University, College of Health Sciences & Professions, Division of Athletic Training. ____________________________________________________________________ Context: Athletic trainers (ATs, more than any other healthcare professional, has expertise in areas of on-field assessment and management of sport related concussion and spinal cord injury. A search of the key words “brain” (n=>100 or “spinal cord/spine” (n=~50 were identified in National Athletic Trainers’ Association Position Statements on Concussion and Spinal Cord Injury. However, a significant gap exists in the basic science knowledge of neuroscience and neuroanatomy. Objective: The goal of this study is to identify the basic science coursework in professional and post-professional athletic training curricula. Design and Setting: This is a descriptive, curricula analysis of CAATE Professional and Post-Professional Athletic Training Programs using web-based search and review. Participants: Curricula for accredited Professional (n=336 and Post-Professional (n=15 Athletic Training Programs were reviewed and analyzed to characteristics basic science content. Interventions: This web-based program review of CAATE standard course content and elective options occurred. Main Outcome Measures: Course titles, numbers and descriptions were accessed at CAATE.net and offerings of anatomy, gross anatomy, neuroanatomy and neuroscience, human physiology, exercise physiology, psychology, chemistry and physics content were quantified. Main outcome measures include frequencies and distributions of courses in each subject area. Results: We reviewed 309

  14. Book Reviews

    Directory of Open Access Journals (Sweden)

    Jan Knappert

    1973-01-01

    Full Text Available - M. Heerma van Voss, J. Vergote, De godsdienst van de Egyptenaren. Romen, Roermond 1971. 125 p., plaat op omslag. - W. Thoden van Velzen-van Wetering, Alan Harwood, Witchcraft, sorcery and social categories among the Safwa. Oxford University Press for the International African Institute, London 1970. 160 p. - J.G. Oosten, E.E. Evans Pritchard, Nuer Religion, Clarendon Press, Oxford University Press, Oxford 1970. 335 p., 15 pl., 5 figs. - A.A. Trouwborst, Robert Brain, Bangwa Funerary Sculpture. Art and Society Series, Edited by Peter J. Ucko. Gerald Duckworth & Company Limited, London 1971, XII en 148 pp., plates, figures, colour plates., Adam Pollock (eds. - A.A. Trouwborst, E.E. Evans-Pritchard, The Azande. History and political institutions. Oxford University Press, London 1971. 444 pages, maps, figures, plates. - John Beattie, Jack Goody, Technology, tradition and the state in Africa. Oxford University Press for the International African Institute, London 1971. 88 pp. - D.H. Reader, Mia Brandel-Syrier, Reeftown elite: A study of social mobility in a modern African community on the Reef. Routledge and Kegan Paul, London 1971. 335 p., 4 figs. - R. Buijtenhuijs, Ariane Deluz, Organisation sociale et tradition orale: Les Guro de Côte d’Ivoire. Cahiers de l’Homme, Mouton et Co., Paris-La Haye 1970, 196 p. - John Beattie, Samwiri Rubaraza Karugire, A history of the Kingdom of Nkore in Western Uganda to 1896. Clarendon Press, Oxford Studies in African Affairs, Oxford 1971. 291 pp. - Jan Vansina, D.W. Cohen, The historical tradition of Busoga. Mukama and Kintu. (Oxford Studies in African Affairs, Clarendon Press: Oxford Univesity Press, Oxford 1972. Pp. X + 218, 9 kaartjes. - Th. Gerold-Scheepers, Alexander Alland jr., Adaptation in cultural evolution: an approach to medical anthropology. Columbia University Press, New York and London, 1970. IX + 188 p. and 6 p. bibliography. - J. Prins, Heribert Adam, South Africa. Sociological Perspectives

  15. Frequency Analysis of Aircraft hazards for License Application

    International Nuclear Information System (INIS)

    K. Ashley

    2006-01-01

    The preclosure safety analysis for the monitored geologic repository at Yucca Mountain must consider the hazard that aircraft may pose to surface structures. Relevant surface structures are located beneath the restricted airspace of the Nevada Test Site (NTS) on the eastern slope of Yucca Mountain, near the North Portal of the Exploratory Studies Facility Tunnel (Figure 1). The North Portal is located several miles from the Nevada Test and Training Range (NTTR), which is used extensively by the U.S. Air Force (USAF) for training and test flights (Figure 1). The NTS airspace, which is controlled by the U.S. Department of Energy (DOE) for NTS activities, is not part of the NTTR. Agreements with the DOE allow USAF aircraft specific use of the airspace above the NTS (Reference 2.1.1 [DIRS 103472], Section 3.1.1 and Appendix A, Section 2.1; and Reference 2.1.2 [DIRS 157987], Sections 1.26 through 1.29). Commercial, military, and general aviation aircraft fly within several miles to the southwest of the repository site in the Beatty Corridor, which is a broad air corridor that runs approximately parallel to U.S. Highway 95 and the Nevada-California border (Figure 2). These aircraft and other aircraft operations are identified and described in ''Identification of Aircraft Hazards'' (Reference 2.1.3, Sections 6 and 8). The purpose of this analysis is to estimate crash frequencies for aircraft hazards identified for detailed analysis in ''Identification of Aircraft Hazards'' (Reference 2.1.3, Section 8). Reference 2.1.3, Section 8, also identifies a potential hazard associated with electronic jamming, which will be addressed in this analysis. This analysis will address only the repository and not the transportation routes to the site. The analysis is intended to provide the basis for: (1) Categorizing event sequences related to aircraft hazards; (2) Identifying design or operational requirements related to aircraft hazards

  16. The 1985 state-by-state assessment of low-level radioactive wastes shipped to commercial disposal sites

    International Nuclear Information System (INIS)

    1986-12-01

    The 1985 report uses the volume of low-level waste reported as received at each commercial disposal site as the national baseline figure. A volume of 75,909 m 3 of radioactive waste containing 748,903 Ci of activity was reported disposed at the commercial sites in 1985. The distribution of these waste volumes by disposal site is presented in Table 1. Table 2 displays typical radionuclides in low-level wastes by sector. Table 3 presents predominant waste forms associated with low-level waste by sector. The total volume and curie values tabulated for each state were obtained directly from the commercial disposal site operators. The total is the sum of the volume and radioactivity reported by Chem Nuclear and US Ecology for each state. Figure 1 displays the disposal capacity remaining at Barnwell, Richland, and Beatty commercial disposal sites as of December 31, 1985. Summary information on commercial nuclear power plant wastes was obtained from semiannual waste and effluent reports submitted to the NRC in accordance with the NRC Regulatory Guide 1.21. Where reported data were not available, data were obtained by communication with the utility. Nonreactor waste volumes are actual amounts recorded as received at the commercial waste repositories in 1985. Waste categories are defined as academic, medical, government, and industrial. New to the 1985 report is Appendix B, 1985 Assessments Listed By Ratified Compacts, as well as the proposed Western and Appalachian compacts. Inclusion of the most accurate information available from all sources has resulted in an improved national waste distribution profile of generator sectors. 11 refs

  17. A QUICK KEY TO THE SUBFAMILIES AND GENERA OF ANTS OF THE SAVANNAH RIVER SITE

    Energy Technology Data Exchange (ETDEWEB)

    Martin, D

    2007-09-04

    This taxonomic key was devised to support development of a Rapid Bioassessment Protocol using ants at the Savannah River Site. The emphasis is on 'rapid' and, because the available keys contained a very large number of genera not known to occur at the Savannah River Site, we found that the available keys were unwieldy. Because these keys contained many more genera than we would ever encounter and because this larger number of genera required more couplets in the key and often required examination of characters that are difficult to assess without higher magnifications (60X or higher), more time was required to process samples. In developing this set of keys I emphasized character states that are easier for nonspecialists to recognize. I recognize that the character sets used may lead to some errors but I believe that the error rate will be small and, for the purpose of rapid bioassessment, this error rate will be acceptable provided that overall sample sizes are adequate. Oliver and Beattie (1996a, 1996b) found that for rapid assessment of biodiversity the same results were found when identifications were done to morphospecies by people with minimal expertise as when the same data sets were identified by subject matter experts. Basset et al. (2004) concluded that it was not as important to correctly identify all species as it was to be sure that the study included as many functional groups as possible. If your study requires high levels of accuracy, it is highly recommended that, when you key out a specimen and have any doubts concerning the identification, you should refer to keys in Bolton (1994) or to the other keys used to develop this area specific taxonomic key.

  18. A QUICK KEY TO THE SUBFAMILIES AND GENERA OF ANTS OF THE SAVANNAH RIVER SITE, AIKEN, SC

    Energy Technology Data Exchange (ETDEWEB)

    Martin, D

    2006-10-04

    This taxonomic key was devised to support development of a Rapid Bioassessment Protocol using ants at the Savannah River Site. The emphasis is on ''rapid'' and, because the available keys contained a large number of genera not known to occur at the Savannah River Site, we found that the available keys were unwieldy. Because these keys contained more genera than we would likely encounter and because this larger number of genera required both more couplets in the key and often required examination of characters that are difficult to assess without higher magnifications (60X or higher) more time was required to process samples. In developing this set of keys I recognize that the character sets used may lead to some errors but I believe that the error rate will be small and, for the purpose of rapid bioassessment, this error rate will be acceptable provided that overall sample sizes are adequate. Oliver and Beattie (1996a, 1996b) found that for rapid assessment of biodiversity the same results were found when identifications were done to morphospecies by people with minimal expertise as when the same data sets were identified by subject matter experts. Basset et al. (2004) concluded that it was not as important to correctly identify all species as it was to be sure that the study included as many functional groups as possible. If your study requires high levels of accuracy, it is highly recommended that when you key out a specimen and have any doubts concerning the identification, you should refer to keys in Bolton (1994) or to the other keys used to develop this area specific taxonomic key.

  19. Legislator's guide to low-level radioactive waste management

    International Nuclear Information System (INIS)

    Jordan, J.M.; Melson, L.G.

    1981-05-01

    The purpose of the guide is to provide state legislators and their staff with information on low-level radioactive waste management, issues of special concern to the states, and policy options. During 1979, producers of low-level radioactive wastes (LLW) faced a crisis. Two of the three commercial disposal sites were temporarily closed and some LLW producers were running short on storage space. For hospitals, clinics, research organizations, and some industries, this meant potential curtailment of activities that produced these materials. Commercial nuclear reactors were not as hard hit during the crisis because they have larger storage areas. The two sites at Beatty, Nevada, and Hanford, Washington, reopened and the immediate crisis was averted. However, the longer term problem of shortage of disposal capacity was just beginning to be recognized. States should be concerned with this problem for several reasons. First, all states produce LLW although the volumes differ among states. Second, states have the responsibility to protect the public health and welfare of their citizens. Third, states may be given the authority to regulate LLW disposal if they enter into agreements with the federal government (Agreement States Program), and 26 states have that authority. Fourth, because of the long-term monitoring and surveillance necessary at a disposal site, states rather than private industry will be held responsible for ensuring that the disposal site is performing safely. Finally, Congress established a policy in 1980 that each state is responsible for the safe disposal of LLW generated within its borders. This policy also includes provisions that could lead to excluding states from using disposal facilities unless they have entered into regional agreements with other states. Two primary options exist for a state: developing its own disposal facility for LLW generated within its borders or joining with other states to develop a regional disposal facility

  20. Radium removal for a small community water-supply system. Research report, 1 October 1985-30 September 1987

    International Nuclear Information System (INIS)

    Mangelson, K.A.

    1988-07-01

    In 1984, a radium-removal treatment plant was constructed for the small community of Redhill Forest located in the central mountains of Colorado. The treatment plant consists of a process for removing iron and manganese ahead of an ion-exchange process for the removal of radium. The raw water comes from deep wells and has naturally occurring radium and iron concentrations of about 30-40 pCi/L and 7-10 mg/L, respectively. Before the raw water enters the main treatment plant, the raw water is aerated to remove radon gas and carbon dioxide. The unique features of the Redhill Forest Treatment Plant are related to the ways in which the radium removed from the raw water is further treated and eventually disposed of as treatment plant waste. A separate system removes only radium from the backwash/regeneration water of the ion exchange process and the radium is permanently complexed on a Radium Selective Complexer (RSC) resin made by Dow Chemical. The RSC resin containing radium is replaced with virgin resin as needed and the resin waste transported to a permanent final disposal site in Beatty, NV. This report presents a detailed description of the Redhill Forest treatment system and the results of in-depth monitoring of the processes and other factors relating to the overall operation of the radium-removal system. Included are descriptions of modifications made in the plant operation to improve the overall system operation and of the procedures for final disposal of the RSC resin-containing radium

  1. Biologic overview for the Nevada Nuclear Waste Storage Investigations, Nevada Test Site, Nye County, Nevada

    International Nuclear Information System (INIS)

    Collins, E.; O'Farrell, T.P.; Rhoads, W.A.

    1982-01-01

    The Nevada Nuclear Waste Storage Investigations project study area includes five major vegetation associations characteristic of the transition between the northern extent of the Mojave Desert and the southern extent of the Great Basin Desert. A total of 32 species of reptiles, 66 species of birds, and 46 species of mammals are known to occur within these associations elsewhere on the Nevada Test Site. Ten species of plants, and the mule deer, wild horse, feral burro, and desert tortoise were defined as possible sensitive species because they are protected by federal and state regulations, or are being considered for such protection. The major agricultural resources of southern Nye County included 737,000 acres of public grazing land managed by the Bureau of Land Management, and 9500 acres of irrigated crop land located in the Beatty/Oasis valleys, the Amargosa Valley, and Ash Meadows. Range lands are of poor quality. Alfalfa and cotton are the major crops along with small amounts of grains, Sudan grass, turf, fruits, and melons. The largest impacts to known ecosystems are expected to result from: extensive disturbances associated with construction of roads, seismic lines, drilling pads, and surface facilities; storage and leaching of mined spoils; disposal of water; off-road vehicle travel; and, over several hundred years, elevated soil temperatures. Significant impacts to off-site areas such as Ash Meadows are anticipated if new residential developments are built there to accommodate an increased work force. Several species of concern and their essential habitats are located at Ash Meadows. Available literature contained sufficient baseline information to assess potential impacts of the proposed project on an area-wide basis. It was inadequate to support analysis of potential impacts on specific locations selected for site characterization studies, mining an exploratory shaft, or the siting and operation of a repository

  2. RMDF leach-field decontamination. Final report

    International Nuclear Information System (INIS)

    Carroll, J.W.; Marzec, J.M.; Stelle, A.M.

    1982-01-01

    The objective of the decontamination effort was to place the Radioactive Materials Disposal Facility (RMDF) leach field in a condition suitable for release for unrestricted use. Radioactively contaminated soil was excavated from the leach field to produce a condition of contamination as low as reasonably achievable (ALARA). The contaminated soil was boxed and shipped to an NRC-licensed burial site at Beatty, Nevada, and to the DOE burial site at Hanford, Washington. The soil excavation project successfully reduced the contamination level in the leach field to background levels, except for less than 0.6 mCi of Sr-90 and trace amounts of Cs-137 that are isolated in cracks in the bedrock. The cracks are greater than 10 ft below the surface and have been sealed with a bituminous asphalt mastic. A pathways analysis for radiation exposure to humans from the remaining radionuclides was performed, assuming intensive home gardening, and the results show that the total first year whole body dose equivalent would be about 0.1 mrem/year. This dose equivalent is a projection for the hypothetical ingestion of vegetables grown on the site. Assuming that an average adult consumes 64 kg of green leafy vegetables per year and that the entire yearly supply could be grown on the site, the amount of ingested Sr-90 and Cs-137 is calculated to be 1100 pCi/year and 200 pCi/year. This ingested quantity would produce a total first year whole body dose equivalent of 0.10 mrem, using the accepted soil-to-plant transfer factors of 0.0172 and 0.010 for Sr-90 and Cs-137, respectively. The whole body dose equivalent exposure value of 0.1 mrem/year is far below the tentative limit established by NRC of 5 mrem/year for areas released for unrestricted use

  3. Digital geologic map of the Thirsty Canyon NW quadrangle, Nye County, Nevada

    Science.gov (United States)

    Minor, S.A.; Orkild, P.P.; Sargent, K.A.; Warren, R.G.; Sawyer, D.A.; Workman, J.B.

    1998-01-01

    This digital geologic map compilation presents new polygon (i.e., geologic map unit contacts), line (i.e., fault, fold axis, dike, and caldera wall), and point (i.e., structural attitude) vector data for the Thirsty Canyon NW 7 1/2' quadrangle in southern Nevada. The map database, which is at 1:24,000-scale resolution, provides geologic coverage of an area of current hydrogeologic and tectonic interest. The Thirsty Canyon NW quadrangle is located in southern Nye County about 20 km west of the Nevada Test Site (NTS) and 30 km north of the town of Beatty. The map area is underlain by extensive layers of Neogene (about 14 to 4.5 million years old [Ma]) mafic and silicic volcanic rocks that are temporally and spatially associated with transtensional tectonic deformation. Mapped volcanic features include part of a late Miocene (about 9.2 Ma) collapse caldera, a Pliocene (about 4.5 Ma) shield volcano, and two Pleistocene (about 0.3 Ma) cinder cones. Also documented are numerous normal, oblique-slip, and strike-slip faults that reflect regional transtensional deformation along the southern part of the Walker Lane belt. The Thirsty Canyon NW map provides new geologic information for modeling groundwater flow paths that may enter the map area from underground nuclear testing areas located in the NTS about 25 km to the east. The geologic map database comprises six component ArcINFO map coverages that can be accessed after decompressing and unbundling the data archive file (tcnw.tar.gz). These six coverages (tcnwpoly, tcnwflt, tcnwfold, tcnwdike, tcnwcald, and tcnwatt) are formatted here in ArcINFO EXPORT format. Bundled with this database are two PDF files for readily viewing and printing the map, accessory graphics, and a description of map units and compilation methods.

  4. Three-dimensional modeling of the Nevada Test Site and vicinity from teleseismic p-wave residuals

    International Nuclear Information System (INIS)

    Monfort, M.E.; Evans, J.R.

    1982-01-01

    A teleseismic P-wave travel-time residual study is described which reveals the regional compressional-velocity structure of southern Nevada and neighboring parts of California to a depth of 280 km. During 1980, 98 teleseismic events were recorded at 53 sites. P-wave residuals were calculated relative to a network-wide average residual for each event and are displayed on maps of the stations for each of four event-azimuth quadrants. Fluctuations in these map-patterns of residuals with approach azimuth combined with results of linear, three-dimensional inversions of some 2887 residuals indicate the following characteristics of the velocity structure of the southern Nevada region: (1) a low-velocity body exists in the upper crust 50 km northeast of Beatty, Nevada, near the Miocene Timber Mountain-Silent Canyon caldera complex. Another highly localized low-velocity anomaly occurs near the southwest corner of the Nevada Test Site (NTS). These two anomalies seem to be part of a low-velocity trough extending from Death Valley, California, to about 50 km north of NTS; (2) there is a high-velocity body in the mantle between 81 and 131 km deep centered about 10 km north of the edge of the Timber Mountain caldera; (3) a broad low-velocity body is delineated between 81 and 131 km deep centered about 30 km north of Las Vegas; (4) there is a monotonic increase in travel-time delays from west to east across the region, probably indicating an eastward decrease in velocity, and lower than average velocities in southeastern Nevada below 31 km; and (5) considerable complexity in three-dimensional velocity structure exists in this part of the southern Great Basin. Inversions of teleseismic P-wave travel-time residuals were also performed on data from 12 seismometers in the immediate vicinity of the NTS to make good use of the closer station spacing in that area

  5. Healthy bread initiative: methods, findings, and theories--Isfahan Healthy Heart Program.

    Science.gov (United States)

    Talaei, Mohammad; Mohammadifard, Noushin; Khaje, Mohammad-Reza; Sarrafzadegan, Nizal; Sajjadi, Firoozeh; Alikhasi, Hasan; Maghroun, Maryam; Iraji, Farhad; Ehteshami, Shahram

    2013-03-01

    The scientific evidences show that the content, baking methods, and types of bread can make health impacts. Bread, as a major part of Iranian diet, demonstrates a significant potential to be targeted as health promotion subject. Healthy Food for Healthy Communities (HFHC) was a project of Isfahan Healthy Heart Program (IHHP), consisting of a wide variety of strategies, like Healthy Bread (HB) Initiative. The HB Initiative was designed to improve the behaviour of both producers and consumers, mainly aiming at making high-fibre, low-salt bread, eliminating the use of baking soda, providing enough rest time for dough before baking (at least one hour), and enough baking time (at least one minute in oven). A workshop was held for volunteer bakers, and a baker-to-baker training protocol under direct supervision was designed for future volunteers. Cereal Organization was persuaded to provide less refined flour that contained more bran. Health messages in support of new breads were disseminated by media and at bakeries by health professionals. Evaluation of the HB Initiative was done using before-after assessments and population surveys. While HB was baked in 1 (0.01%) bakery at baseline, 402 (41%) bakeries in the intervention area joined the HB Initiative in 2009. Soda was completely eliminated and fibre significantly increased from 4 +/- 0.4 g% before study to 12 +/- 0.6 g% after the intervention (p bread decreased from 13 +/- 1.8 g% to 2 +/- 0.5 g% and was expressed as the most important advantage of this initiative by consumers. People who lived in Isfahan city consumed whole bread 6 times more than those who lived in reference area Arak (p breads as a healthy choice that were compatible with local dishes and made a model to solve the longstanding problems of bread. It used various health promotion approaches but was best consistent with Beattie's model.

  6. Preparation of minor actinides targets or blankets by the means of Ionic Exchange Resin

    Energy Technology Data Exchange (ETDEWEB)

    Picart, S.; Mokhtari, H.; Ramiere, I.; Jobelin, I. [CEA, Nuclear Energy Division, RadioChemistry and Process Department, Actinides Chemistry Laboratory, BP17171, Bagnols-sur-Ceze, 30207 (France)

    2009-06-15

    The objective of our R and D work is the elaboration by the use of ionic exchange resin of minor actinide precursors for target or blanket dedicated to their transmutation in sodium fast reactor. From the beginning, the resin process called WAR (acronym of Weak Acid Resin) was developed in the 70's at the ORNL for the making of uranium carbide kernels for the high temperature gas reactor [1] [2]. By now, our aim is to extend this concept to the manufacturing of minor actinides oxide mixed with uranium oxides [3]. More precisely, this process can be divided in two major steps: the loading of the resin and the thermal treatment of the fully loaded resin driving either to oxide or carbide phases depending on the gas atmosphere. The difficulty stems from the preparation of the loading solutions which must fulfill precise conditions of pH in presence of actinides cations prone to hydrolysis. Furthermore, the proportions of uranium and minor actinides in solutions must be adjusted to fit the right ratio in the solid. The study presented here will then focus on the experiments and tests which enable us to optimize the fixing of minor actinides on ionic exchange resin and their carbonization in oxide. [1] G. W. Weber, R. L. Beatty et V. J. Tennery, Nuclear Technology, 35, 217-226, (1977), 'Processing and composition control of weak-acid-resin derived fuel microspheres'. [2] K. J. Notz, P. A. Haas, J. H. Shaffer, Radiochimica Acta, 25, 153-160, (1978). 'The preparation of HTGR Fissile Fuel Kernels by Uranium Loading of Ion Exchange Resin'. [3] S. Picart, H. Mokhtari, I. Ramiere, 'Plutonium Futures, The Science 2008', 7-11 july 2008, Dijon, France. 'Modelling of the ionic Exchange between a weak acid resin in its ammonium form and a minor actinide'. (authors)

  7. Design and operational considerations of United States commercial near-surface low-level radioactive waste disposal facilities

    International Nuclear Information System (INIS)

    Birk, S.M.

    1997-10-01

    In accordance with the Low-Level Radioactive Waste Policy Amendments Act of 1985, states are responsible for providing for disposal of commercially generated low-level radioactive waste (LLW) within their borders. LLW in the US is defined as all radioactive waste that is not classified as spent nuclear fuel, high-level radioactive waste, transuranic waste, or by-product material resulting from the extraction of uranium from ore. Commercial waste includes LLW generated by hospitals, universities, industry, pharmaceutical companies, and power utilities. LLW generated by the country''s defense operations is the responsibility of the Federal government and its agency, the Department of Energy. The commercial LLRW disposal sites discussed in this report are located near: Sheffield, Illinois (closed); Maxey Flats, Kentucky (closed); Beatty, Nevada (closed); West Valley, New York (closed); Barnwell, South Carolina (operating); Richland, Washington (operating); Ward Valley, California, (proposed); Sierra Blanca, Texas (proposed); Wake County, North Carolina (proposed); and Boyd County, Nebraska (proposed). While some comparisons between the sites described in this report are appropriate, this must be done with caution. In addition to differences in climate and geology between sites, LLW facilities in the past were not designed and operated to today''s standards. This report summarizes each site''s design and operational considerations for near-surface disposal of low-level radioactive waste. The report includes: a description of waste characteristics; design and operational features; post closure measures and plans; cost and duration of site characterization, construction, and operation; recent related R and D activities for LLW treatment and disposal; and the status of the LLW system in the US

  8. Completion Report for Well ER-EC-8

    International Nuclear Information System (INIS)

    2004-01-01

    Well ER-EC-8 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the summer of 1999 as part of the U.S. Department of Energy's hydrogeologic investigation program in the Western Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 129.8 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 609.6 meters. One completion string with three isolated slotted intervals was installed in the well. A preliminary composite, static water level was measured at the depth of 98.4 meters, 24 days after installation of the completion string. Detailed lithologic descriptions with stratigraphic assignments are included in the report. These are based on evaluation of composite drill cuttings collected every 3 meters, and 20 sidewall samples taken at various depths below 157.9 meters, supplemented by geophysical log data and results of detailed chemical and mineralogical studies of rock samples. Drilling began in Tertiary-age tuff of the Thirsty Canyon Group, and penetrated tuffs of the Beatty Wash Formation, tuff of Buttonhook Wash, and the upper portion of the Ammonia Tanks Tuff. The geologic interpretation of data from this well helps define the location of the western margin of the Timber Mountain caldera complex in the southwestern Nevada volcanic field. Geologic and hydrologic data from the well will aid in development of models to predict groundwater flow and contaminant migration within and near the Nevada Test Site

  9. Lithology, fault displacement, and origin of secondary calcium carbonate and opaline silica at Trenches 14 and 14D on the Bow Ridge Fault at Exile Hill, Nye County, Nevada

    International Nuclear Information System (INIS)

    Taylor, E.M.; Huckins, H.E.

    1995-01-01

    Yucca Mountain, a proposed site for a high-level nuclear-waste repository, is located in southern Nevada, 20 km east of Beatty, and adjacent to the southwest comer of the Nevada Test Site (NTS) (fig. 1). Yucca Mountain is located within the Basin and Range province of the western United States. The climate is semiarid, and the flora is transitional between that of the Mojave Desert to the south and the Great Basin Desert to the north. As part of the evaluation, hydrologic conditions, especially water levels, of Yucca Mountain and vicinity during the Quaternary, and especially the past 20,000 years, are being characterized. In 1982, the US Geological Survey, in cooperation with the US Department of Energy (under interagency agreement DE-A104-78ET44802), excavated twenty-six bulldozer and backhoe trenches in the Yucca Mountain region to evaluate the nature and frequency of Quaternary faulting (Swadley and others, 1984). The trenches were oriented perpendicular to traces of suspected Quaternary faults and across projections of known bedrock faults into Quaternary deposits. Trench 14 exposes the Bow Ridge Fault on the west side of Exile Hill. Although the original purpose of the excavation of trench 14 was to evaluate the nature and frequency of Quaternary faulting on the Bow Ridge Fault, concern arose as to whether or not the nearly vertical calcium carbonate (the term ''carbonate'' in this study refers to calcium carbonate) and opaline silica veins in the fault zone were deposited by ascending waters (ground water). These veins resemble in gross morphology veins commonly formed by hydrothermal processes

  10. 1984 state-by-state assessment of low-level radioactive wastes shipped to commercial disposal sites

    International Nuclear Information System (INIS)

    1985-12-01

    The 1984 report uses the volume of low-level waste reported as received at each commercial disposal site as the national baseline figure. A volume of 75,429 m 3 of radioactive waste containing 600,909 Ci of activity was reported disposed at the commercial sites in 1984. The distribution of these waste volumes by disposal site is presented in Table 1. Table 2 displays typical radionuclides in low-level wastes by sector. Table 3 presents predominant waste forms associated with low-level waste by sector. The total volume and curie values tabulated for each state were obtained directly from the commercial disposal site operators. The total is the sum of the volume and radioactivity reported by Chem Nuclear and US Ecology for each state. Figure 1 displays the disposal capacity remaining at Barnwell, Richland, and Beatty commercial disposal sites as of December 31, 1984. Summary information on commercial nuclear power plant wastes was obtained from semiannual waste and effluent reports submitted to the NRC in accordance with the NRC Regulatory Guide 1.21. Where reported data were not available, data were obtained by communication with the utility. Non-reactor waste volumes are actual amounts recorded as received at the commercial waste repositories in 1984. Waste categories are defined as academic, medical, government, and industrial. Academic includes university hospitals and medical and nonmedical research facilities. The medical category includes hospitals and clinics, research facilities, and private medical offices. The industrial category includes private entities such as research and development companies, manufacturers, nondestructive testing, mining, and radiopharmaceutical manufacturers. Government includes state and federal agencies. Data from previous publications were also used as a comparison. 11 refs., 1 fig., 3 tabs

  11. RESEARCH OF COMPETITION IN DEPOSIT MARKET OF UKRAINE BASED ON THE PANZAR-ROSSE MODEL

    Directory of Open Access Journals (Sweden)

    Iryna Didenko

    2016-11-01

    Full Text Available The problem in an adequate assessment of the level of competition in the banking market has prompted researchers to search constantly some new methods. The most famous of them were later successfully adapted to the banking market, are a models of Bresnahan, Panzar-Rosse, Bertrand, Iwat, Monti-Klein-Modesto Barros and others. In Ukraine, the process of assessing the level of competition in the banking sector is very relevant, in line with the recent reforms of particular relevance and distribution. Regarding the domestic deposit market, there is a shortage of qualitative analysis of this issue, unlike foreign practice. Therefore this study we try to solve this problem. The key goal of researchers in this study is in a detailed analysis to identify the important factors which make influence on the allocated markets, in particular on lending and deposit rates. Based on these factors there could be implemented internal adjustment processes taking place in the markets. The purpose of the article is to determine the level of competition in the deposit market of Ukraine in 2006-2015 basing on nonstructural Panzar- Rosse model and identify key factors that affect this level. Methodology. To research the level of competition in the deposit market of Ukraine the Panzar-Rosse model was used, in which separate 11 models were built using the integrated tool “Multiple regression” in the software package of statistics analysis STATISTICA. The input data in the model was presented with the information on financial performance of Ukrainian banks during ten years from 01.01.2005 till 01.01.2015. Results of this research showed that in Ukrainian deposit market there is a monopolistic competition, as proved by the calculated values of H-statistics index. The year of 2008, in the context of the global economic crisis, was marked as an unbalanced period for deposit market of Ukraine. Practical implications. Knowing the current state of competition level in the

  12. Book Reviews

    Directory of Open Access Journals (Sweden)

    Joseph Aquilina

    1976-01-01

    Full Text Available - John Beattie, Aylward Shorter, Chiefship in Western Tanzania: A political history of the Kimbu. Clarendon Press, Oxford 1972. Pp. xxvi, 439: 5 plates, 13 maps. - Jan Knappert, Francis Mading Deng, The Dinka and their songs. Oxford Library of African Literature. Oxford University Press 1973. 301 pp. - J.H. Konter, Carsten Murmann, Change and development in East African husbandry. A study of four societies during the colonial period. Akademisk Forlag, Kopenhagen 1974, 125 blz., 4 kaarten en auteurs index. - J.G. Oosten, Jean Buxton, Religion and healing in Mandari. Oxford 1973, 268 pp. Clarendon Press. - J.G. Oosten, Jozef Franz Thiel, La situation religieuse des Mbiem. Ceeba Publications, Série II, vol. I, Steyler Verlag, St. Augustin. Bandundu 1972. - J.J. de Wolf, A.F. Droogers, De gevaarlijke reis. Jongensinitiatie bij de Wagenia van Kisangani (Zäire. Academisch proefschrift. 1974, Vrije Universiteit te Amsterdam. - John Beattie, J.W. van Nieuwenhuijsen, Diviners and their ancestor spirits: study of the izangoma among the Nyuswa in Natal, South Africa. Uitgave 3, Afdeling Culturele Antropologie, Antropologische-Sociologische Centrum, Universiteit van Amsterdam, 1974. 37 pp. - Geert A. Banck, Peter Kloos, Het Indianenprobleem in Zuid Amerika. Terreinverkenningen in de Culturele Antropologie no. 2. Assen, Van Gorcum/Orion. 144 pag., paperback. - H. Heijmerink, S. Reissig Ortiz, Uncertainties in peasant farming, a Colombian case. London School of Economics Monographs on Social Anthropology, No. 46. University of London. The Athlone Press, New York. Humanities Press Inc., 1973, 294 pp. - Peter Kloos, Janet Siskend, To hunt in the morning. New York, Oxford University Press, 1973, 214 pp. - Ger van Roon, A.E. van Niekerk, Sociologie en sociale verandering in Latijns-Amerika. Deel II De naties, geredigeerd en ingeleid door Dr. A.E. van Niekerk. Universitaire Pers Rotterdam - Standaard Wetenschappelijke Uitgeverij Antwerpen 1974, 199 blz. - R

  13. Trophic development in a volcanic lake with closed hydric balance. Lake Martignano; Evoluzione trofica di un lago vulcanico a bilancio idrico chiuso. Il lago di Martignano

    Energy Technology Data Exchange (ETDEWEB)

    Falleni, F.; Bruno, M. [Istituto Superiore di Sanita' , Rome (Italy); Marchiori, E. [Istituto Sperimentale per la Zootecnia, Monterotondo, Rome (Italy); Congestri, R. [Rome Univ. Tor Vergata, Rome (Italy); Gasperi, E.; Brambullo, M. [Azienda Sanitaria Locale A, Rome (Italy); Amadeio, R. [Comune di Campagnano, Rome (Italy)

    2000-12-01

    Martignano lake is a particular charming volcanic lake in the countryside of Rome. Recently it was included in a project of Regional Wildlife Park. The lack of immissaries and emissaries, the quite long renewal time and the very short homeothermic period of two-months in a year, make the lake susceptible of trophic evolution. The comparison between the present data and those from previous studies seems to confirm such a slow development towards this way, with a nutrient level (nitrate 0.97 mg/L; total phosphorus 11.14 {mu}g/L) and chlorophyll a concentrations (10.68 {mu}g/L), typical of mesotrophic waters. The analysis of nutrient data expressed as annual mean value in percentage from the coastal stations, suggests an under lied farming influence, and points out the need to adopt fast reduction measures, to lower the phosphorus load in acceptable levels for the lake ecosystem. [Italian] Il lago di Martignano (207 m.s.l.m) e' situato nell'Italia centrale, a 35 Km a nord di Roma. I laghi di origine vulcanica rappresentano una tipologia relativamente rara rispetto all'insieme dei corpi d'acqua componenti la limnologia classica. La loro esistenza si determina in regioni con passata o attuale pronunciata attivita' tettonica. La mancanza di immissari ed emissari che caratterizza questo invaso rende particolarmente vulnerabile il suo livello trofico da parte delle contaminazioni da insediamenti urbani ed agricoli circostanti. Ai fini di valutare l'attuale velocita' di ricambio idrico del lago, il suo livello trofico e la conseguente capacita' di automantenimento di un basso livello trofico delle acque, e' stato pianificato il presente studio articolato in 13 mesi di campionamento. Si e' constatato che il valore medio annuale della clorofilla a, 10.68 {mu}g/L, mentre la presenza dei nitrati si aggira sul valore medio di 0.97 mg/L, cio' permette di ipotizzare l'origine agricola della maggior parte dei nutrienti del

  14. RDF gasification with water vapour: influence of process temperature on yield and products composition; Gassificazione con vapore del CDR: influenza della temperatura di processo su rese e composizione dei prodotti

    Energy Technology Data Exchange (ETDEWEB)

    Galvagno, S.; Casciaro, G.; Russo, A.; Casu, S.; Martino, M.; Portofino, S. [C. R. ENEA Trisaglia, Rotondella (Italy). PROT-STP

    2005-08-01

    -line, per la qualificazione dell'effluente gassoso. I dati sperimentali mostrano che la resa in gas aumenta con la temperatura e che, per quanto riguarda la composizione, il gas si arricchisce in idrogeno a spese principalmente di altri composti gassosi, indicando cosi' una maggiore estensione dei cracking secondari nella frazione gassosa a temperature piu' alte. Il gas ottenuto a temperature di processo uguali o superiori a 950{sup o}C presenta caratteristiche tali da renderlo utilizzabile in celle a combustione; a temperature piu' basse, la composizione del gas ne suggerisce un impiego finale nelle reazioni di sintesi del feedstock recycling. Il basso contenuto di organico nel residuo solido non suggerisce altri utilizzi del char diversi dallo smaltimento in discarica.

  15. Tolerability of NGX-4010, a capsaicin 8% patch, in conjunction with three topical anesthetic formulations for the treatment of neuropathic pain

    Directory of Open Access Journals (Sweden)

    Webster LR

    2012-01-01

    Full Text Available Lynn R Webster1, John F Peppin2, Frederick T Murphy3,4, Jeffrey K Tobias5, Geertrui F Vanhove51Lifetree Clinical Research and Pain Clinic, Lifetree Medical Inc, Salt Lake City, UT, USA; 2Clinical Research Division, The Pain Treatment Center of the Bluegrass, Lexington, KY, USA; 3Altoona Center for Clinical Research, Duncansville, PA, USA; 4University of Pennsylvania, School of Medicine, Philadelphia, PA, USA; 5NeurogesX Inc, San Mateo, CA, USABackground: The objective of this study was to assess the safety, tolerability, and preliminary efficacy of NGX-4010, a capsaicin 8% patch, following pretreatment with three different topical anesthetics in patients with peripheral neuropathic pain.Methods: This open-label, multicenter study enrolled 117 patients with post-herpetic neuralgia, HIV-associated distal sensory polyneuropathy, or painful diabetic neuropathy. Patients received pretreatment with one of three lidocaine 4%-based topical anesthetics (L.M.X.4® [Ferndale Laboratories Inc, Ferndale, MI], Topicaine® Gel [Estela Basso, Jupiter, FL], or Betacaine Enhanced Gel 4 [Tiberius Inc, Tampa, FL] for 60 minutes followed by a single 60- or 90-minute NGX-4010 application, and were followed for 12 weeks. Tolerability and safety measures included “pain now” Numeric Pain Rating Scale (NPRS scores, dermal assessments, medication use for treatment-related pain, adverse events (AEs, clinical laboratory parameters, physical examinations, and vital signs. The primary efficacy variable was the percentage change in mean NPRS scores for “average pain for the past 24 hours” from baseline to weeks 2 through 12.Results: Treatment with NGX-4010 following pretreatment with any of the three topical anesthetics was generally safe and well tolerated. Nearly all patients completed ≥90% of the planned NGX-4010 application duration. The most common treatment-related AEs, application-site burning and application-site pain, were transient, mostly mild or moderate

  16. Turbo-gas emissions and integrated pollution prevention and control (IPPC); Emissioni da turbogas e prevenzione e limitazione integrata dell'inquinamento

    Energy Technology Data Exchange (ETDEWEB)

    Mariani, M. [ISPESL/DIPIA, Roma (Italy); Sera, B. [Roccadarce (Italy)

    2005-10-15

    processo di combustione e quindi sul tasso di produzione degli NO{sub x}. Ancora, lo studio indica le soluzioni tecnologiche piu appropriate e disponibili per minimizzare la produzione degli NO{sub x}, e per abbatterli prima che gli stessi siano immessi, come gas di scarico, in atmosfera, Infine, lo studio dimostra che le turbine a gas sono da considerarsi macchine a basso indice d'impatto ambientale soprattutto quando utilizzano come combustibile il gas naturale.

  17. Cathalitic burners for residential gas appliances; Bruciatori catalitici di gas naturale per apparecchi domestici

    Energy Technology Data Exchange (ETDEWEB)

    Accornero, R.; Canci, F. [Italgas Spa, Rome (Italy)

    2000-12-01

    The growing interest for the rational use of natural gas as a primary source of energy and for the reduction of pollutant emissions from combustion processes has kindled, in recent years, a widespread interest in studies and experimental investigations on the use of premix burners (either ceramic or metallic) for heat generators in domestic applications. The present paper deals with the R and D activities developed in this field by Italgas, Politecnico di Torino (Dipartimento di Scienza dei Materiali ed Ingegneria Chimica) and Merloni TermoSanitari, (an Italian gas boiler manufacturer). The technology hereby presented aims at reducing the pollutants emissions (CO, NO{sub x}, HC) in a wide range of working regimes of the burner, typical of residential heat appliances. The positive results in a lab scale experimental pilot plant have been in some cases confirmed in experimental runs performed on boiler prototypes suitable for large scale industrial production. Some projects, financially supported by the European Community and involving, beyond the above mentioned partners, also other gas distribution companies, universities, research institutes and burner manufacturers, are currently in progress to further analyse the performance of these burners. [Italian] Il crescente interesse per l'uso razionale del gas naturale quale fonte energetica primaria e quale combustibile a basso impatto ambientale, ha suscitato, nei tempi piu' recenti, un vasto interesse per gli studi e per le ricerche nel settore dei bruciatori di gas di tipo a premiscelazione, siano essi in materiale ceramico che metallico, allo scopo di rendere praticabile la loro applicazione nei generatori di calore di tipo domestico. L'articolo descrive l'attivita' di R e S sviluppata da Italgas, Politecnico di Torino - Dipartimento di Scienza dei Materiali ed Ingegneria Chimica - e da Merloni TermoSanitari. La tecnologia sperimentata e' finalizzata alla riduzione delle emissioni di

  18. Banks, environment and sustainable development. EMAS regulation n. 761/2001/EC applied to the financial institutions; Banche, ambiente e sviluppo sostenibile l'adesione degli istituti finanziari al regolamento EMAS

    Energy Technology Data Exchange (ETDEWEB)

    Andriola, L; Ingrisano, G; Sampognaro, G [ENEA, Divisione Caratterizzazione dell' Ambiente e del Territorio, Centro Ricerche Casaccia, Rome (Italy)

    2001-07-01

    gli investimenti con finalita' ambientali; come finanziatori - sviluppando nuovi prodotti finanziari che incoraggino lo sviluppo sostenibile; come valutatori - stimando rischi e opportunita' ambientali nel project financing; come potenti stakeholders - come investitori e finanziatori esse possono esercitare una considerevole influenza sulle aziende; come soggetti inquinanti - sebbene non paragonabili alle industrie pesanti, gli istituti finanziari consumano risorse naturali. Dallo studio di tali aspetti ambientali e' emerso che la banca dovrebbe introdurre la variabile ambientale nella gestione interna per ridurre i propri impatti e, soprattutto, nella concessione di crediti, nello sviluppo di nuovi prodotti finanziari finalizzati ad incentivare le aziende ad investire in tecnologie a basso impatto ambientale e ad adottare sistemi di gestione ambientale (EMAS, ISO14001), e nell'assistenza ai piccoli risparmiatori nelle scelte di investimento, ad esempio consigliando Fondi verdi.

  19. The use of peracetic acid in drinking water systems: flow tests; L'acido peracetico in potabilizzazione: prove in flusso

    Energy Technology Data Exchange (ETDEWEB)

    Ragazzo, P. [Consorzio per l' Acquedotto del Basso Piave, San Dona' di Piave, VE (Italy); Navazio, G. [Padua Univ., Padua (Italy). Dipt. dei Processi Chimici dell' Ingegneria; Cavadone, A. [Solvay Chimica Italia S.p.A., Milan (Italy)

    2000-09-01

    In a previous research, a preliminary study was carried out on the disinfection efficiency of peracetic acid (PAA), comparing it to that of other disinfectants that are typically used, in batch tests with dosage values ranging from 0.5 to 5 ppm. The study was carried out on samples of water collected from several significant points of the treatment process at the main water treatment plant in Jesolo (Venice, Italy). On the basis of results (basically positive at that time) obtained from these tests, a 400 litre/hour pilot plant was built, as a lower scale reproduction of the drink water treatment system mentioned earlier, in order to study the characteristics of PAA even in tests that could more realistically simulate the flow of water along the process. These tests essentially confirmed the kinetics of the spontaneous hydrolysis to CH{sub 3} COOH+H{sub 2}O{sub 2} and those of dismutation to CH{sub 3}COOH+O{sub 2}, with half-life time values ranging from 3 to 12 hours, depending on the characteristics of the water (especially the pH factor) and the PAA concentration values. [Italian] In un precedente lavoro e' stato effettuato un preventivo studio sull'efficienza disinfettiva dell'acido peracetico, anche in confronto con gli altri piu' usuali disinfettanti, in prove condotte in batch, con dosaggi compresi tra 0.5 e 5 ppm, su campioni di acqua prelevati dai diversi punti significativi della linea di trattamento della centrale di Jesolo (Torre Caligo), gestita dal Consorzio Acquedottistico del Basso Piave di S. Dona' di Piave (Venezia). Sulla base dei risultati, sostanzialmente positivi, e' stato costruito un impianto pilota da 400l/h, riproducente, in scala, la linea di potabilizzazione su ricordata, per studiare le caratteristiche del PAA anche in prove piu' probanti condotte in flusso. In tali prove sono state sostanzialmente riconfermate le cinetiche delle reazioni spontanee di dirolisi a CH{sub 3}COOH+H{sub 2}O{sub 2} e di

  20. La leucemia del bambino come causa di disgregazione familiare

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    G. Varchetta

    2003-05-01

    Full Text Available

    Introduzione: le patologie del bambino, soprattutto se gravi e durature, possono essere definite come “malattie della famiglia” a causa dell’intensità di assistenza richiesta, delle difficoltà organizzative quotidiane e dello stress causato. Obiettivo: identificare il ruolo di alcuni potenziali fattori di rischio coinvolti nella rottura di famiglie di bambini leucemici.

    Materiali e metodi: mediante l’uso di questionari, sono state studiate, durante l’anno 2002, 150 cartelle cliniche di bambini leucemici dell’ospedale pediatrico “Santobono-Pausillipon”- Dipartimento di Oncologia; 11 casi sono stati esclusi per incompletezza dei dati. Outcome è stata considerata la “separazione familiare.” Sono state analizzate le seguenti variabili: trapianto di midollo osseo, lavoro del padre, della madre e loro età ed educazione, sesso ed età del bambino (CA, numerosità della famiglia, stato socio-economico, probabilità clinica di guarire (CPR, appartenenza ad una associazione. Sono state condotte analisi bivariate e logistiche. Risultati: all’analisi bivariata CA e CPR, entrambi stratificati in tre livelli, sono risultati associati alla separazione. L’Odds Ratio grezzo (OR della separazione familiare con CA di 5/10 anni e bambini di 11 anni o più a confronto con quelli d’età di 0/4 era, rispettivamente, di 8.68 (p=0.02 e di 5.7 (p=0.07. L’OR grezzo della separazione con un CPR medio e un CPR buono confrontato con un CPR basso ha dato rispettivamente 0.35 (p=0.02 e 0.08 (p‹0.001. Un modello logistico che includeva CPR come variabile principale e controllata per CA ha evidenziato che la probabilità di guarigione è media o alta e, dopo aver aggiustato per l’età del bambino, è stato ottenuto un rischio di rottura familiare rispettivamente di 0.29 (p=0.01 e 0.08 (p=0.02.

    Conclusioni: la rottura dell’unità familiare è evento frequente in caso di grave

  1. Segnalazioni

    Directory of Open Access Journals (Sweden)

    Emanuele Monegato

    2014-11-01

    Full Text Available Antonietta Buonauro, Trauma, cinema e media. Immaginari catastrofici e cultura visuale del nuovo millennio, Roma, Bulzoni, 2014, 190 pp. ISBN 978-88-7870-921-8 Barbara Greco y Laura Pache Caballo, eds., Sobrenatural, fantástico y metarreal. La perspectiva de América Latina, Madrid, Biblioteca Nueva, 2014, 334 pp. ISBN 978-84-16095-64-3 Chiara Bolognese, Piste di un naufragio. Cartografia di Roberto Bolaño, Salerno, Arcoiris, 2014, 322 pp. ISBN 978-88-96583-59-3 Cinzia Scarpino, US Waste. Rifiuti e sprechi d’America. Una storia dal basso, Milano, Il Saggiatore, 2011, 325 pp. ISBN 9788865760871 Cinzia Schiavini, Sulle strade d’America. L’autobiografia di viaggio statunitense contemporanea, Milano, Shake, 2011, pp. 238, ISBN 978-88-97109-06-8 Gibson John, Fiction and the Weave of Life, Oxford & NY, OUP, 2007, 201 pp. ISBN 9780199299522 Gloria Staffieri, L’opera italiana. Dalle origini alle riforme del secolo dei Lumi (1590-1790, Roma, Carocci, 2014, 447 pp. ISBN 978-88-430-7108-1 Horacio Quiroga, I perseguitati, Salerno, Arcoiris, 2014, 64 pp. ISBN 978-88-96583-63-0 Lee Edelman, No Future: Queer Theory and the Death Drive, Durham, Duke University Press, 2004, 208 pp. ISBN 978-0822333692 Marco Canani and Sara Sullam, eds., Parallaxes. Virginia Woolf Meets James Joyce, Newcastle upon Tyne, Cambridge Scholars Publishing, 2014, 206 pp. ISBN 978-1-4438-5623-2 Miklos David, eds., Estática doméstica. Tres generaciones de cuentistas peruanos (1951-1981, México, UNAM, 2005, 353 pp. ISBN 970-32-2525-X Óscar de Borbolla, Le vocali maledette, Salerno, Arcoiris, 2014, 78 pp. ISBN 978-88-96583-43-2 Roald Dahl, The Hitch-Hiker, Impara l’inglese con Roald Dahl, note e glossario a cura di Marta Cai, Milano, Vallardi, 2014, 77 pp. ISBN 978-88-6731-451-5 Roberto Arlt, Un viaggio terribile, Salerno, Arcoiris, 2014, 95 pp. ISBN 978-88-96583-57-9 Ziauddin Sardar and Borin Van Loon, Introducing Cultural Studies, Cambridge, Icon Books, 1998, 175

  2. Quando la Generazione Erasmus incontra la Generazione Precaria. La mobilità transnazionale dei giovani italiani e spagnoli

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    Luca Raffini

    2014-07-01

    Full Text Available Uno dei più importanti risultati del processo di integrazione europea è la costruzione di uno spazio transnazionale in cui i cittadini europei possono muoversi liberamente. La mobilità favorisce dinamiche di europeizzazione dal basso –o di europeizzazione orizzontale–, e lo sviluppo di pratiche cross-nazionali e amplia le risorse individuali e relazionali a disposizione dei giovani per progettare i propri percorsi professionali e di vita. La Generazione Erasmus definisce giovani socializzati a un humus culturale transnazionale e fortemente identificati con l’Europa. Nell’attuale contesto di crisi economica, a sperimentare la mobilità sono sempre più i giovani altamente qualificati dei paesi dell’Europa del sud, quale strategia individuale cui ricorrere per trovare risposta ai problemi connessi alla precarietà, alla disoccupazione, alla sotto-qualificazione degli impieghi. Il risultato è che la mobilità può assumere il volto di un obbligo, più che di una scelta e, più che dinamiche di europeizzazione orizzontale, può favorire una “fuga dei cervelli” dai paesi del sud ai paesi del centro e del nord Europa. L’articolo, focalizzandosi sui giovani italiani e spagnoli, si chiede cosa succede quando la Generazione Erasmus incontra la Generazione Precaria, analizzando cause ed effetti della mobilità, sul piano micro e macro sociale e sul piano politico. | One of the main achievement of the European integration process is the making of a transnational space where European citizens can freely circulate. Mobility promotes a kind of bottom-up, or horizontal europeanization, and the spread of cross-national practices. It also contributes to a widening in the individual and relational resources available to youth to carry out their professional and personal life projects. The so called Erasmus Generation, defines young peoples socialized to a transnational cultural humus and highly identified with Europe. Indeed, in the current

  3. La salute del christifidelis celiaco tra dieta gluten free e invalidità delle ostie quibus glutinum ablatum est

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    Tiziana Di Iorio

    2015-04-01

    SOMMARIO: 1. L’Eucarestia: “augusto” strumento per la salute deichristifideles nell’economia della salvezza - 2. La transustanziazione - 3. La malattia celiaca e l’unico rimedio terapeutico: la dieta gluten free - 4. Ilchristifidelis affetto dalla sprue celiaca tra dieta gluten free e pane mere triticeus - 5. Prime disposizioni sul divieto dell’uso di ostie quibus glutinum ablatum est - 6. La particola con “una minima quantità di glutine” - 7. Le vigenti prescrizioni sulla validità della materia eucaristica e l’uso di ostie a basso contenuto di glutine - 8. La normativa sulla comunione dei celiaci tra sospetti e apprezzamenti - 9. Ultime precisazioni sull’uso del pane con poca quantità di glutine - 10. Conclusioni. The health of the christifidelis celiac between diet gluten free and invalidity of the hosts quibus glutinum ablatum est.  ABSTRACT: The communion of celiac has aroused the attention of the Congregation for the Doctrine of the Faith for the direct connection between gluten, cause of the disease, and bread mere triticeus, precious element of the Eucharist. The complex matter concerns the impelling urgency to allow the christifidelis celiac to follow a super stricte gluten free diet, necessary way to the protection of his mental and physical health, without expelling him from the eucharistic banquet, indispensable instrument of salvation of his own soul. Therefore, in the saving mission of the Church called to the salus animarum of every man, without discriminating exclusions, direct specific norms are emanated to harmonize the dogmatic demands, connected to the Eucharestic, and the therapeutic needs related to mental and physical health of the faithful with the disease. Such norms have faced the validity of the eucharistic matter sealing the invalidity of the hosts quibus glutinum ablatum est, with a meaningful evolution, during the time. It stays, nevertheless, the suspect of an exhaustive solution of the question

  4. Le disuguaglianze sociali nell'abitudine al fumo in Italia, 1980- 2000

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    B. Federico

    2003-05-01

    Full Text Available

    Obiettivi: misurare la direzione e l’entità delle disuguaglianze socio-economiche nell’abitudine al fumo in Italia durante gli ultimi due decenni, con attenzione sia al livello nazionale che macro-regionale.

    Metodi: sono stati utilizzati dati provenienti da sei indagini ISTAT sullo stato di salute dal 1980 al 2000. Abbiamo usato il livello di istruzione come indicatore dello stato socio-economico. Per ogni indagine e livello di analisi (nazionale e macroregionale, è stata calcolata la prevalenza, standardizzata per età, del consumo di tabacco in diversi gruppi sociali.

    Per ottenere una misura di sintesi delle disuguaglianze, abbiamo stimato l’Odds Ratio (OR ed il Relative Index of Inequality (con intervallo di confidenza al 95% attraverso un’analisi di regressione logistica.

    Risultati: negli uomini di età compresa tra 25 e 49 anni, l’Odds Ratio del consumo di tabacco di una persona con un basso livello di istruzione confrontata con una di un alto livello è risultato pari a 1,26 (IC 95%: 1,16 - 1,37 nel 1980 ed a 1,71 (IC 95%: 1,62 - 1,80 nel 2000. Nelle donne della stessa fascia di età, l’associazione tra stato sociale ed abitudine al fumo si è trasformata da positiva (OR=0,43 in negativa (OR=1,12. Nelle donne più anziane, la prevalenza di fumatrici è risultata maggiore tra quelle più istruite, con un gap tra classi sociali che si restringe nel tempo. Nel periodo considerato le stime degli OR sono risultate costantemente inferiori nel Sud rispetto al Centro ed al Nord Italia, nonostante la somiglianza nei trend temporali nelle differenti macro-regioni.

    Conclusioni: le disuguaglianze tra gruppi sociali sono aumentate, specialmente nelle giovani generazioni. Le regioni meridionali seguono quelle del centro e nord Italia nel diffondersi dell’epidemia dell’abitudine al fumo.

  5. Sieropositivitá per HIV, HBV e HCV negli utenti del Servizio di Tossicodipendenza di Formia (ASL di Latina

    Directory of Open Access Journals (Sweden)

    G. La Torre

    2003-05-01

    Full Text Available

    Obiettivi: valutare la prevalenza sieropositività per HIV, HBV e HCV nei tossicodipendenti afferenti al Ser.T di Formia (LT.

    Materiali e metodi: sono state consultate le cartelle cliniche degli afferenti al Ser.T. nel 2002, estraendo dati relativi ai parametri socio-demografici ed alle sieropositività. L’analisi statistica ha previsto l’impiego del test del χ2 e della regressione logistica multipla.

    Risultati: sono stati presi in considerazione 135 tossicodipendenti, di cui 103 (76.3% maschi e 32 (23.7% femmine. L’età mediana dell’inizio della tossicodipendenza e della presa in carico presso il servizio erano, rispettivamente, di 18 e di 23 anni. Il 94.1% dei tossicodipendenti risulta dipendente primariamente da eroina, il 5.2% da cocaina e lo 0.7% da alcol. Relativamente alle positività per i virus considerati, 7 soggetti (5.2% sono risultati positivi all’HIV, 23 (17% sieropositivi per HBV e 50 (37% sieropositivi per HCV. L’analisi multivariata mostra che sono associate alla sieropositività per HCV la sieropositività per HBV (OR = 3.87 e l’età della presa in carico presso il servizio superiore a 25 anni (OR = 1.88; alla sieropositività per HBV l’occupazione saltuaria (OR = 4.58, la HCV positività (OR = 4.41 e la HIV positività (OR = 5.39; alla sieropositività per HIV l’età della presa in carico presso il servizio superiore a 25 anni (OR = 4.94.

    Discussione: l’indagine ha messo in evidenza prevalenze di sieropositività per HCV, HBV e HIV decisamente inferiori a quelle registrate in altre realtà italiane ed internazionali. Una possibile spiegazione potrebbe essere ricercata nei bassi livelli di sieropositività per questi virus nella popolazione generale del Basso Lazio, o nella scarsa abitudine di scambiarsi le siringhe fra tossicodipendenti di questa area geografica.

  6. I Passiuna tu Christù - Rito e teatro di una cantica popolare della Grecìa Salentina

    Directory of Open Access Journals (Sweden)

    Diana Costa

    2012-01-01

    Full Text Available Abstract – IT Questo articolo si basa sugli esiti di una ricerca di campo condotta nei paesi della Grecìa Salentina,una zona del basso Salento, dove si riscontra una peculiare modalità di esecuzione della cantica popolare grìca conosciuta come I Passiuna tu Christù (La Passione di Cristo. Attorno alla metà degli anni ´90 del ´900 la tradizione della cantica è stata oggetto di un prezioso recupero, fondato sulla memoria e disponibilità di alcuni anziani cantori, che l’ha riportata in vita dopo anni di silenzio. Lo studio si è quindi focalizzato sull'esecuzione di Zollino, uno dei comuni grecanico-salentini, dove opera l'associazione culturale "Bottega del Teatro" che per prima ha promosso il recupero di cui si è detto. Protagonista e interprete raffinato della versione zollinese è l'anziano cantore Antimo Pellegrino, la cui voce si fa teatro attraverso un uso sapiente del corpo fatto di gesti stilizzati, regolati da codici che consentono di comprendere il divenire performativo, ossia il testo in grìco, anche a chi non intende tale idioma. Abstract – EN This article is based on the results of a field research conducted in the countries of the Grecìa Salentina, an area of Salento, where there is a particular execution method of the folksong known as I Passiuna tu Christù (The Passion of the Christ. Around the mid-90s of the 20th century the tradition of this folksong has been the subject of a careful recovery, based on memory and availability of some older singers, who brought it back to life after years of silence. The study then focused on the Zollino’s execution, one of the grecanico-salentino’s common, in which works the cultural association "Bottega del Teatro", the first promoter of this recovery. The old singer Antimo Pellegrino is the player and interpreter of the Zollino’s refined version, whose voice becomes theater through a wise use of body made of stylized gestures, regulated by codes that allow you to

  7. Impact of the tsunami (December, 2004 on the long tailed macaque of Nicobar Islands, India

    Directory of Open Access Journals (Sweden)

    Kuppusamy Sivakumar

    2010-08-01

    Full Text Available Abstract
    We carried out a standard survey to assess the distribution and abundance of Macaca fascicularis umbrosa of Nicobar Islands (India after the tsunami which washed the whole region in 2004 and compared them with those reported for 2000. A total of 40 groups, comprising 814 monkeys, was sighted, group size varying from 7 to 98 animals (mean ± SD = 20.35 ± 1.82. There was no significant change in the number of groups sighted in the interior parts of the islands before and after the tsunami, whilst the number of groups sighted in coastal areas was significantly lower after the tsunami. Also, the adults/juveniles ratio in the group varied from ca. 1:1 to 1:0.4. A fairly low ratio of immatures to adult females suggests that the tsunami also affected the population structure of the monkeys. The destruction of major coastal fruit-trees exploited by monkeys might be the reason for their lower presence in coastal areas. Future restoring of fruit plantations could enhance the human-wildlife conflict.

    Riassunto
    Impatto dello tsunami (Dicembre 2004 sul macaco delle Isole Nicobar, India
    La distribuzione e l’abbondanza di Macaca fascicularis umbrosa sulle Isole Nicobar (India sono state stimate tramite campionamenti standardizzati dopo lo tsunami che ha colpito l’intera regione nel 2004 e comparate a quelle ottenute nel 2000. Sono stati avvistati 40 gruppi, formati da 7 a 98 animali (media ± DS = 20.35 ± 1.82, per un totale di 814 macachi. Non sono state rilevate variazioni significative del numero di gruppi presenti nelle parti interne delle isole, mentre sono diminuiti i gruppi osservati nelle foreste costiere. Il rapporto tra adulti e giovani è variato da circa 1:1 a 1:0.4. In particolare, il basso numero di giovani per femmina adulta suggerisce che lo tsunami possa aver influito negativamente sulla struttura della popolazione. La distruzione

  8. The Germanists and the Historical School of Law: German Legal Science between Romanticism, Realism, and Rationalization

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    Gerhard Dilcher

    2016-01-01

    Full Text Available The essay, originally written in German as an introduction to a volume of collected papers, shows the influence of the Historical School of Law on legal, historical and social sciences in Germany throughout the 19th and even 20th centuries – a time span running contrary to the dominate view that sees the end of the School in the middle of the 19th century. In my view the School constitutes not only a method for developing norms of private law out of the historical materials of Roman and German-Germanic laws, but is based on a wider conception of culture, law and history that is also connected to the political positions of that time. In Savigny’s founding pamphlet, »The vocation of our time ...«, two major theoretical topics for this long-lasting influence can be found: The Romantic one, which views law as a part of culture and parallel to language and custom, based on the »spirit of the people«, and, on the other side, the rationality of the European tradition of Roman law, which was developed and administered by jurists. These two basic points, in part standing in contradiction to one another, form a fertile tension that provides an impulse to the intellectual discussions and new movements in jurisprudence and history analysed in the text. Realism, founded in the connection of both sciences to political and social life, builds a kind of »basso continuo« and acts as a counterbalance to the former two. And it is in this context that the works of Jacob Grimm, Puchta and Beseler, Heinrich Brunner, Georg von Below and others are analysed, in particular the works of Otto von Gierke and Max Weber. Finally, evidence is furnished that a new image of the medieval period, and its impact on law, as a centre of Western identity was outlined in the 20th century by authors like Ernst Kantorowicz, Fritz Kern, Otto Brunner and, last but not least, by Harold J. Berman (walking in the footsteps of Eugen Rosenstock- Huessy, all of whom were situated in

  9. Anti-Inflammatory Mechanism of Neural Stem Cell Transplantation in Spinal Cord Injury

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    Zhijian Cheng

    2016-08-01

    Full Text Available Neural stem cell (NSC transplantation has been proposed to promote functional recovery after spinal cord injury. However, a detailed understanding of the mechanisms of how NSCs exert their therapeutic plasticity is lacking. We transplanted mouse NSCs into the injured spinal cord seven days after SCI, and the Basso Mouse Scale (BMS score was performed to assess locomotor function. The anti-inflammatory effects of NSC transplantation was analyzed by immunofluorescence staining of neutrophil and macrophages and the detection of mRNA levels of tumor necrosis factor-α (TNF-α, interleukin-1β (IL-1β, interleukin-6 (IL-6 and interleukin-12 (IL-12. Furthermore, bone marrow-derived macrophages (BMDMs were co-cultured with NSCs and followed by analyzing the mRNA levels of inducible nitric oxide synthase (iNOS, TNF-α, IL-1β, IL-6 and IL-10 with quantitative real-time PCR. The production of TNF-α and IL-1β by BMDMs was examined using the enzyme-linked immunosorbent assay (ELISA. Transplanted NSCs had significantly increased BMS scores (p < 0.05. Histological results showed that the grafted NSCs migrated from the injection site toward the injured area. NSCs transplantation significantly reduced the number of neutrophils and iNOS+/Mac-2+ cells at the epicenter of the injured area (p < 0.05. Meanwhile, mRNA levels of TNF-α, IL-1β, IL-6 and IL-12 in the NSCs transplantation group were significantly decreased compared to the control group. Furthermore, NSCs inhibited the iNOS expression of BMDMs and the release of inflammatory factors by macrophages in vitro (p < 0.05. These results suggest that NSC transplantation could modulate SCI-induced inflammatory responses and enhance neurological function after SCI via reducing M1 macrophage activation and infiltrating neutrophils. Thus, this study provides a new insight into the mechanisms responsible for the anti-inflammatory effect of NSC transplantation after SCI.

  10. The ethics of heroism in medieval and American Indian tales.

    Science.gov (United States)

    Scott, A

    1990-01-01

    Oral-traditional stories detail their heroes' growth through a narrative pattern of exile and return that places the heroes in situations repeatedly challenging their strength and resolve. Through the motif of the quest, medieval and American Indian tales alike reaffirm general psychological truths that bear upon our understanding of human nature. Stories about heroes are stories about us: about our desires to grow up, to defeat death, to prove ourselves in difficult situations, and to achieve recognition or admiration among our peers (Becker, 1973, p. 4). In this way, medieval and American Indian tales are about self-actualization. They maintain that "one has within oneself proclivity toward growth and unity of personality ... and an automatic thrust toward expression" of these qualities (Yalom, 1980, p. 9). All forms of literature, however, reflect ideas peculiar to their cultures. The ways in which these basic human truths are represented in medieval and American Indian tales suggest the differing religious or social concerns that have informed these truths and have given them shape. To a large degree, the medieval knight's view of "self" and "other" encompasses the view that Western humanity has had (and continues to have) of itself. This is a view conditioned upon the superiority of the "self" as measured against the inferiority of the "other," reinforced through existing social (hierarchial) and religious (Judeo-Christian) codes of behavior. Such codes are not only inadequate to the task of interpreting American Indian perceptions of "self" and "other," they are inimical to the ethical foundation underlying them. Scott Momaday remarks that "you cannot understand how the Indian thinks of himself in relation to the world around him unless you understand his conception of what is appropriate; particularly what is morally appropriate within the context of that relationship" (Basso, 1984, p. 46). For the American Indian hero, self-actualization is self

  11. Banks, environment and sustainable development. EMAS regulation n. 761/2001/EC applied to the financial institutions; Banche, ambiente e sviluppo sostenibile l'adesione degli istituti finanziari al regolamento EMAS

    Energy Technology Data Exchange (ETDEWEB)

    Andriola, L.; Ingrisano, G.; Sampognaro, G. [ENEA, Divisione Caratterizzazione dell' Ambiente e del Territorio, Centro Ricerche Casaccia, Rome (Italy)

    2001-07-01

    'ambiente: come investitori - sostenendo gli investimenti con finalita' ambientali; come finanziatori - sviluppando nuovi prodotti finanziari che incoraggino lo sviluppo sostenibile; come valutatori - stimando rischi e opportunita' ambientali nel project financing; come potenti stakeholders - come investitori e finanziatori esse possono esercitare una considerevole influenza sulle aziende; come soggetti inquinanti - sebbene non paragonabili alle industrie pesanti, gli istituti finanziari consumano risorse naturali. Dallo studio di tali aspetti ambientali e' emerso che la banca dovrebbe introdurre la variabile ambientale nella gestione interna per ridurre i propri impatti e, soprattutto, nella concessione di crediti, nello sviluppo di nuovi prodotti finanziari finalizzati ad incentivare le aziende ad investire in tecnologie a basso impatto ambientale e ad adottare sistemi di gestione ambientale (EMAS, ISO14001), e nell'assistenza ai piccoli risparmiatori nelle scelte di investimento, ad esempio consigliando Fondi verdi.

  12. Investigating Food and Beverage Industry Market Structure and Market Power Based on Leo and Bresnahan’s Approach

    Directory of Open Access Journals (Sweden)

    M. Nabishahikitash

    2016-03-01

    , Safdarhoseiniet all (2, Mazhari&Yazdani. Yet,foreign studies conducted in this area are varied in different sectors. For example, the studies Angelini&cetorell (15 andRezitis (24 in the banking system can be mentioned.Of the other foreign studies Leo (21, Bresnahan (12, Abayasiri (8, Boyle & Hall (14, Saitone& etal. (25, Koontz (20, Duravall (17, Steen (29, Salhofer and etAl. (28, Allender (10, Siton and et al. (25, Rigoberto et all (22, Lopez & etal. (22, Oustapassidis& etal. (23 can be cited. The model in this paper to estimate market power used for the food and beverage industries has been developed by Bresnahan& Leo. In this model,by considering demand and supply market powercan be investigated. In the next step, marginal cost (cost function is Translog cost and marginal revenue will be obtained. In the final step,by estimatingthe final equation market power can be calculated. The type of industrial classification used in this study is the International Standard Industrial Classification (ISIC. This kind of classification is widely used for empirical studies because of lack of industrial data on the basis of other classifications. We use firm level data aggregated to the4- digit ISIC code of industries. The purpose of this study is to estimate the market structure and market power of the food and drink industry in Iran.For estimating market power, conjectural variation is used. Results and DiscussionIn oligopoly theory, conjectural variation is the belief that one firm has about the way its competitors may react if it varies its output or price. The firm forms a conjecture about the variation in the other firm's output that will accompany any change in its own output. For example, in the classic Cournot model of oligopoly, it is assumed that each firm treats the output of the other firms as given when it chooses its output. This is sometimes called the "Nash conjecture" as it underlies the standard Nash equilibrium concept. However, alternative assumptions can be made

  13. Healthy Bread Initiative: Methods, Findings, and Theories—Isfahan Healthy Heart Program

    Science.gov (United States)

    Talaei, Mohammad; Khaje, Mohammad-Reza; Sarrafzadegan, Nizal; Sajjadi, Firoozeh; Alikhasi, Hasan; Maghroun, Maryam; Iraji, Farhad; Ehteshami, Shahram

    2013-01-01

    The scientific evidences show that the content, baking methods, and types of bread can make health impacts. Bread, as a major part of Iranian diet, demonstrates a significant potential to be targeted as health promotion subject. Healthy Food for Healthy Communities (HFHC) was a project of Isfahan Healthy Heart Program (IHHP), consisting of a wide variety of strategies, like Healthy Bread (HB) Initiative. The HB Initiative was designed to improve the behaviour of both producers and consumers, mainly aiming at making high-fibre, low-salt bread, eliminating the use of baking soda, providing enough rest time for dough before baking (at least one hour), and enough baking time (at least one minute in oven). A workshop was held for volunteer bakers, and a baker-to-baker training protocol under direct supervision was designed for future volunteers. Cereal Organization was persuaded to provide less refined flour that contained more bran. Health messages in support of new breads were disseminated by media and at bakeries by health professionals. Evaluation of the HB Initiative was done using before-after assessments and population surveys. While HB was baked in 1 (0.01%) bakery at baseline, 402 (41%) bakeries in the intervention area joined the HB Initiative in 2009. Soda was completely eliminated and fibre significantly increased from 4±0.4 g% before study to 12±0.6 g% after the intervention (p<0.001). The preparation and baking times remarkably increased. Wastage of bread decreased from 13±1.8 g% to 2±0.5 g% and was expressed as the most important advantage of this initiative by consumers. People who lived in Isfahan city consumed whole bread 6 times more than those who lived in reference area Arak (p<0.001). The HB Initiative managed to add new breads as a healthy choice that were compatible with local dishes and made a model to solve the long-standing problems of bread. It used various health promotion approaches but was best consistent with Beattie's model. PMID

  14. LifePrint: a novel k-tuple distance method for construction of phylogenetic trees

    Directory of Open Access Journals (Sweden)

    Fabián Reyes-Prieto

    2011-01-01

    Full Text Available Fabián Reyes-Prieto1, Adda J García-Chéquer1, Hueman Jaimes-Díaz1, Janet Casique-Almazán1, Juana M Espinosa-Lara1, Rosaura Palma-Orozco2, Alfonso Méndez-Tenorio1, Rogelio Maldonado-Rodríguez1, Kenneth L Beattie31Laboratory of Biotechnology and Genomic Bioinformatics, Department of Biochemistry, National School of Biological Sciences, 2Superior School of Computer Sciences, National Polytechnic Institute, Mexico City, Mexico; 3Amerigenics Inc, Crossville, Tennessee, USAPurpose: Here we describe LifePrint, a sequence alignment-independent k-tuple distance method to estimate relatedness between complete genomes.Methods: We designed a representative sample of all possible DNA tuples of length 9 (9-tuples. The final sample comprises 1878 tuples (called the LifePrint set of 9-tuples; LPS9 that are distinct from each other by at least two internal and noncontiguous nucleotide differences. For validation of our k-tuple distance method, we analyzed several real and simulated viroid genomes. Using different distance metrics, we scrutinized diverse viroid genomes to estimate the k-tuple distances between these genomic sequences. Then we used the estimated genomic k-tuple distances to construct phylogenetic trees using the neighbor-joining algorithm. A comparison of the accuracy of LPS9 and the previously reported 5-tuple method was made using symmetric differences between the trees estimated from each method and a simulated “true” phylogenetic tree.Results: The identified optimal search scheme for LPS9 allows only up to two nucleotide differences between each 9-tuple and the scrutinized genome. Similarity search results of simulated viroid genomes indicate that, in most cases, LPS9 is able to detect single-base substitutions between genomes efficiently. Analysis of simulated genomic variants with a high proportion of base substitutions indicates that LPS9 is able to discern relationships between genomic variants with up to 40% of nucleotide

  15. Mega-rings Surrounding Timber Mountain Nested Calderas, Geophysical Anomalies: Rethinking Structure and Volcanism Near Yucca Mountain (YM), Nevada

    Science.gov (United States)

    Tynan, M. C.; Smith, K. D.; Savino, J. M.; Vogt, T. J.

    2004-12-01

    Observed regional mega-rings define a zone ˜80-100 km in diameter centered on Timber Mountain (TM). The mega-rings encompass known smaller rhyolitic nested Miocene calderas ( ˜11-15 my, structural relationships. Mega-rings consist of arcuate faulted blocks with deformation (some remain active structures) patterns showing a genetic relationship to the TM volcanic system; they appear to be spatially associated and temporally correlated with Miocene volcanism and two geophysically identified crustal/upper mantle features. A 50+ km diameter pipe-like high velocity anomaly extends from crustal depth to over 200 km beneath TM (evidence for 400km depth to NE). The pipe is located between two ˜100 km sub-parallel N/S linear trends of small-magnitude earthquake activity, one extending through the central NV Test Site, and a second located near Beatty, NV. Neither the kinematics nor relational mechanism of 100km seismically active N/S linear zones, pipe, and mega-rings are understood. Interpreted mega-rings are: 1) Similar in size to larger terrestrial volcanic complexes (e.g., Yellowstone, Indonesia's Toba system); 2) Located in the region of structural transition from the Mohave block to the south, N/S Basin and Range features to the north, Walker Lane to the NW, and the Las Vegas Valley shear zone to the SE; 3) Associated with the two seismically active zones (similar to other caldera fault-bounded sags), the mantle high velocity feature, and possibly a regional bouguer gravity anomaly; 4) Nearly coincident with area hydrologic basins and sub-basins; 5) Similar to features described from terrestrial and planetary caldera-collapse studies, and as modeled in laboratory scaled investigations (ice melt, balloon/sand). Post Mid-Miocene basalts commonly occur within or adjacent to the older rhyolitic caldera moats; other basaltic material occurs marginal to both the outer rings of the interpreted mega-ring system and high velocity pipe. The YM repository may be situated in

  16. Experimental determination of trace-element partitioning between pargasite and a synthetic hydrous andesitic melt

    Science.gov (United States)

    Brenan, J. M.; Shaw, H. F.; Ryerson, F. J.; Phinney, D. L.

    1995-10-01

    therefore offer a means to discern the loss of amphibole from the melting assemblage. Elastic strain theory is applied to the partitioning data after the approaches of Beattie and Blundy and Wood and is used to predict amphibole/melt partition coefficients at conditions of P, T and composition other than those employed in this study. Given values of DCa, DTi and DK from previous partitioning studies, this approach yields amphibole/melt trace-element partition coefficients that reproduce measured values from the literature to within 40-45%. This degree of reproducibility is considered reasonable given that model parameters are derived from partitioning relations involving iron- and potassium-free amphibole.

  17. Hemoterapia e febre Dengue Blood banking e Dengue fever

    Directory of Open Access Journals (Sweden)

    Estácio F. Ramos

    2008-02-01

    Full Text Available Dengue is an endemic/epidemic arboviral disease with a variable symptomatic benign course, but potentially fatal. Once in an inhabited area, the disease will exist forever, with the best achievement being to keep vectors suppressed and the disease under control. Tiger mosquitoes (aedes aegypti, aedes albopictus are active breeders and urban hunters, becoming resistant to pesticides. Global warming and population growth are propelling the disease worldwide at tropical and subtropical regions, victimizing new populations. Dengue virus is very infective, and has been transmitted by needlestick, intrapartum, through blood transfusion and mucosal contact with blood. One patient got dengue while undergoing bone marrow transplantation. We address the growing dengue epidemics in Brazil, with more than half a million official cases in 2007, to estimate the risks of transfusion transmitted dengue. Calculations however were surpassed by reality: the major Blood Center in Brazil (FHSP-USP has found dengue virus in one out of each thousand blood units. In 2007, industry sold 2,6 million disposable blood bags in Brazil. Plotting data from FHSP-USP to the whole country, 2600 blood units would have been infective. Through blood components, around 5000 patients must have received dengue virus intravenously. Beatty et al. estimated to be 1:1300 the risk for dengue transmission through blood transfusion in Puerto Rico, close to what has been demonstrated in Sao Paulo. Throughout Brazil, the average risk may be lower, but the epidemics grows towards a worst scenario. Whatever the risk is, it imposes that all blood units in Brazil (and wherever dengue is endemic must be EIA tested for dengue NS1 antigen. This marker appears early after infection, and the EIA testing platform is available at all blood banks. Also, donors must report febrile states up to two weeks after donation. Morbidity from dengue virus injected in hospitalized patients is unknown, but it may lead

  18. The southern cape conductive belt (South Africa): Its composition, origin and tectonic significance

    Science.gov (United States)

    De Beer, J. H.; Van Zijl, J. S. V.; Gough, D. I.

    1982-03-01

    is transported in the seafloor until it reaches a subduction, where it accumulates because of its low density. Examples of such accumulations are cited. Finally, it is shown that any iron in the olivine and pyroxene in the original basalt precipitates, when these silicates are hydrated to serpentine, as magnetite which is the dominant mineral conferring high electrical conductivity and high magnetic susceptibility on serpentinites. In particular the Beattie static magnetic anomaly requires, in our model calculation, a very high susceptibility readily attainable in basalt at 15-20% serpentinization. The authors know of no other rock able to provide this high susceptibility. A similar percentage of serpentinization provides the density required to model the gravity anomalies.

  19. Frequency Analysis of Aircraft hazards for License Application

    Energy Technology Data Exchange (ETDEWEB)

    K. Ashley

    2006-10-24

    The preclosure safety analysis for the monitored geologic repository at Yucca Mountain must consider the hazard that aircraft may pose to surface structures. Relevant surface structures are located beneath the restricted airspace of the Nevada Test Site (NTS) on the eastern slope of Yucca Mountain, near the North Portal of the Exploratory Studies Facility Tunnel (Figure 1). The North Portal is located several miles from the Nevada Test and Training Range (NTTR), which is used extensively by the U.S. Air Force (USAF) for training and test flights (Figure 1). The NTS airspace, which is controlled by the U.S. Department of Energy (DOE) for NTS activities, is not part of the NTTR. Agreements with the DOE allow USAF aircraft specific use of the airspace above the NTS (Reference 2.1.1 [DIRS 103472], Section 3.1.1 and Appendix A, Section 2.1; and Reference 2.1.2 [DIRS 157987], Sections 1.26 through 1.29). Commercial, military, and general aviation aircraft fly within several miles to the southwest of the repository site in the Beatty Corridor, which is a broad air corridor that runs approximately parallel to U.S. Highway 95 and the Nevada-California border (Figure 2). These aircraft and other aircraft operations are identified and described in ''Identification of Aircraft Hazards'' (Reference 2.1.3, Sections 6 and 8). The purpose of this analysis is to estimate crash frequencies for aircraft hazards identified for detailed analysis in ''Identification of Aircraft Hazards'' (Reference 2.1.3, Section 8). Reference 2.1.3, Section 8, also identifies a potential hazard associated with electronic jamming, which will be addressed in this analysis. This analysis will address only the repository and not the transportation routes to the site. The analysis is intended to provide the basis for: (1) Categorizing event sequences related to aircraft hazards; (2) Identifying design or operational requirements related to aircraft hazards.

  20. Analyzing the impact of changing size and composition of a crop model ensemble

    Science.gov (United States)

    Rodríguez, Alfredo

    2017-04-01

    on IRS features. References Martre, P., Wallach, D., Asseng, S., Ewert, F., Jones, J.W., Rötter, R.P., Boote, K.J., Ruane, A.C., Thorburn, P.J., Cammarano, D., Hatfield, J.L., Rosenzweig, C., Aggarwal, P.K., Angulo, C., Basso, B., Bertuzzi, P., Biernath, C., Brisson, N., Challinor, A.J., Doltra, J., Gayler, S., Goldberg, R., Grant, R.F., Heng, L., Hooker, J., Hunt, L.A., Ingwersen, J., Izaurralde, R.C., Kersebaum, K.C., Muller, C., Kumar, S.N., Nendel, C., O'Leary, G., Olesen, J.E., Osborne, T.M., Palosuo, T., Priesack, E., Ripoche, D., Semenov, M.A., Shcherbak, I., Steduto, P., Stockle, C.O., Stratonovitch, P., Streck, T., Supit, I., Tao, F.L., Travasso, M., Waha, K., White, J.W., Wolf, J., 2015. Multimodel ensembles of wheat growth: many models are better than one. Glob. Change Biol. 21, 911-925. Pirttioja N., Carter T., Fronzek S., Bindi M., Hoffmann H., Palosuo T., Ruiz-Ramos, M., Tao F., Trnka M., Acutis M., Asseng S., Baranowski P., Basso B., Bodin P., Buis S., Cammarano D., Deligios P., Destain M.-F., Doro L., Dumont B., Ewert F., Ferrise R., Francois L., Gaiser T., Hlavinka P., Jacquemin I., Kersebaum K.-C., Kollas C., Krzyszczak J., Lorite I. J., Minet J., Minguez M. I., Montesion M., Moriondo M., Müller C., Nendel C., Öztürk I., Perego A., Rodriguez, A., Ruane A.C., Ruget F., Sanna M., Semenov M., Slawinski C., Stratonovitch P., Supit I., Waha K., Wang E., Wu L., Zhao Z., Rötter R.P, 2015. A crop model ensemble analysis of temperature and precipitation effects on wheat yield across a European transect using impact response surfaces. Clim. Res., 65:87-105, doi:10.3354/cr01322 Wallach, D., Mearns, L.O. Ruane, A.C., Rötter, R.P., Asseng, S. (2016). Lessons from climate modeling on the design and use of ensembles for crop modeling. Climate Change (in press) doi:10.1007/s10584-016-1803-1.

  1. An infrastructure for the integration of geoscience instruments and sensors on the Grid

    Science.gov (United States)

    Pugliese, R.; Prica, M.; Kourousias, G.; Del Linz, A.; Curri, A.

    2009-04-01

    ). In this paper i) we define the need for integration of instrumentation in the Grid, ii) we introduce the solution of the Instrument Element, iii) we demonstrate a suitable end-user web portal for accessing Grid resources, iv) we describe from the Grid-technological point of view the process of the integration to the Grid of two advanced environmental monitoring devices. References [1] M. Surridge, S. Taylor, D. De Roure, and E. Zaluska, "Experiences with GRIA—Industrial Applications on a Web Services Grid," e-Science and Grid Computing, First International Conference on e-Science and Grid Computing, 2005, pp. 98-105. [2] A. Chervenak, I. Foster, C. Kesselman, C. Salisbury, and S. Tuecke, "The data grid: Towards an architecture for the distributed management and analysis of large scientific datasets," Journal of Network and Computer Applications, vol. 23, 2000, pp. 187-200. [3] B. Allcock, J. Bester, J. Bresnahan, A.L. Chervenak, I. Foster, C. Kesselman, S. Meder, V. Nefedova, D. Quesnel, and S. Tuecke, "Data management and transfer in high-performance computational grid environments," Parallel Computing, vol. 28, 2002, pp. 749-771. [4] E. Frizziero, M. Gulmini, F. Lelli, G. Maron, A. Oh, S. Orlando, A. Petrucci, S. Squizzato, and S. Traldi, "Instrument Element: A New Grid component that Enables the Control of Remote Instrumentation," Proceedings of the Sixth IEEE International Symposium on Cluster Computing and the Grid (CCGRID'06)-Volume 00, IEEE Computer Society Washington, DC, USA, 2006. [5] R. Ranon, L. De Marco, A. Senerchia, S. Gabrielli, L. Chittaro, R. Pugliese, L. Del Cano, F. Asnicar, and M. Prica, "A Web-based Tool for Collaborative Access to Scientific Instruments in Cyberinfrastructures." 1 The DORII project is supported by the European Commission within the 7th Framework Programme (FP7/2007-2013) under grant agreement no. RI-213110. URL: http://www.dorii.eu 2 Istituto Nazionale di Oceanografia e di Geofisica Sperimentale. URL: http://www.ogs.trieste.it

  2. Three Gorges Reservoir Area: soil erosion under natural condition vs. soil erosion under current land use

    Science.gov (United States)

    Schönbrodt, Sarah; Behrens, Thorsten; Scholten, Thomas

    2010-05-01

    Xiangjiaba site (mean 640.1 t ha-1 a-1) the maximum soil erosion of 1,115.4 t ha-1 a-1 under natural conditions is negligible lower. Compared to these erosion rates the mean soil loss under current land use is considerably lower (Xiangxi Catchment: mean 161.5 t ha-1 a-1; Backwater area: mean 166.3 t ha-1 a-1; Quyuan: mean 211.2 t ha-1 a-1; Xiangjiaba: mean 158.6 t ha-1 a-1). However, soil loss of maximum 2,662.2 t ha-1 a-1 for Xiangxi Catchment, 2,397.9 t ha-1 a-1 for the backwater area, 1,689.9 t ha-1 a-1 for Quyuan site, and 957.1 t ha-1 a-1 for Xiangjiaba site are also potentially possible. According to the Chinese Soil Erosion Rate Standard (cf. Xu et al., 2008) almost 44 % of the area of the Xiangxi Catchment show extreme (> 80 t ha-1 a-1) soil erosion which mainly occur in the backwater area. Our results show that the Xiangxi Catchment is already highly prone to soil erosion under natural conditions. In places, the current land use in the mountainous relief of the Xiangxi Catchment still increases the potential soil erosion to an extreme high level. However, mean potential soil loss rates under current land use lie under those due to the natural disposition. This is due to the fact that the natural disposition to soil erosion does not consider the complete topography factor (LS factor), that effects the potential soil loss (R² = 0.77) by the human-influenced erosive slope length through farmland terraces. Moreover, our results indicate an urgent need of proper management and conservation decisions in order to reduce soil erosion against the background of a high land use dynamic in a region with low carrying capacity (Beattie, 2002). Literature Beattie, J. (2002): Dam Building, Dissent, And Development: The Emergence Of The Three Gorges Project. New Zealand Journal of Asian Studies, Vol. 4(1): 138-158. Behrens, T., Schmidt, K. and Scholten, T. (2008). An approach to remove uncertainties in nominal environmental covariates and soil class maps. In: Hartemink, A. E., Mc

  3. Distribution and ecology of Dormice (Myoxidae in Sicily: a preliminary account

    Directory of Open Access Journals (Sweden)

    Maurizio Sarà

    1995-05-01

    boschi decidui di querce e faggio e, più in basso di noccioli, querce e castagni dei Nebrodi, Peloritani e Madonie. Il Ghiro è presente anche sull'Etna ed in un'area meridionale della Sicilia (Iblei. Il Quercino mostra la distribuzione più ampia (21,2% ed è presente in una gran varietà di habitat dal livello del mare fino alle faggete delle Madonie. I Mioxidi in Sicilia risultano predati finora occasionalmente dalla Volpe e dal Lanario e raramente dal Barbagianni e dall'Allocco. Solo il Ghiro risulta predato regolarmente (5% dall'Allocco e risulta la preda più importante in termini di biomassa (47% nei boschi dell'Etna e dei Nebrodi. Il periodo di letargo, desunto da osservazioni dirette e dalle borre, sembrerebbe normale (autunno inoltrato-primavera alle alte quote e assente o molto ridotto e discontinuo sotto i 400 m.

  4. Distorsioni strutturali della regolamentazione prudenziale delle banche (Structural distortions in prudential regulation of banks

    Directory of Open Access Journals (Sweden)

    Mario Tonveronachi

    2012-04-01

    Full Text Available A livello nazionale, la regolamentazione finanziaria basata su divieti, cioè la cosiddetta regolamentazione strutturale, veniva accusata di produrre rilevanti distorsioni. Il grado di concorrenza ne risultava limitato, favorendo inefficienze di tutti i tipi; la cultura del rischio ne risultava indebolita; ampi poteri discrezionali erano usati dalle autorità nazionali per distorcere i meccanismi di mercato e la proprietà pubblica distorceva la concorrenza e favoriva pratiche clientelari.Una nuova comune cultura regolamentativa è quindi emersa, basata sulla libera concorrenza interna al settore bancario e per il sistema finanziario nel suo complesso. Essa richiede l’eliminazione di stretti limiti all’operatività bancaria, l’abbandono del principio di specializzazione tra attività di banca commerciale e attività finanziaria non bancaria, l’affermazione della proprietà privata, l’assoggettamento delle banche a una più forte disciplina di mercato, anche con riguardo alla loro corporate governance. Le regole di Basilea producono distorsioni non meno serie di quelle attribuite alla precedente regolamentazione strutturale. La concorrenza eccessiva non è meno dannosa di un basso grado di concorrenza, l’impostazione del level playing field aiuta la grande dimensione e pratiche di too big to fail, i capital crunches producono seri effetti sull’economia, mentre i costi di regolamentazione assorbono importanti quote delle risorse delle banche minori. È materia di ulteriore ricerca verificare se la nuova impostazione di regolamentazione abbia anche favorito un aumento nella quota del reddito nazionale assorbito dal sistema finanziario senza aver prodotto una migliore distribuzione dei rischi e un proporzionale aumento in quella che James Tobin (1984 ha definito efficienza di piena assicurazione.   At the national level, financial regulation based on prohibitions, the so-called structural rules, was accused of producing significant

  5. Distorsioni strutturali della regolamentazione prudenziale delle banche (Structural distortions in prudential regulation of banks

    Directory of Open Access Journals (Sweden)

    Mario Tonveronachi

    2009-12-01

    Full Text Available A livello nazionale, la regolamentazione finanziaria basata su divieti, cioè la cosiddetta regolamentazione strutturale, veniva accusata di produrre rilevanti distorsioni. Il grado di concorrenza ne risultava limitato, favorendo inefficienze di tutti i tipi; la cultura del rischio ne risultava indebolita; ampi poteri discrezionali erano usati dalle autorità nazionali per distorcere i meccanismi di mercato e la proprietà pubblica distorceva la concorrenza e favoriva pratiche clientelari.Una nuova comune cultura regolamentativa è quindi emersa, basata sulla libera concorrenza interna al settore bancario e per il sistema finanziario nel suo complesso. Essa richiede l’eliminazione di stretti limiti all’operatività bancaria, l’abbandono del principio di specializzazione tra attività di banca commerciale e attività finanziaria non bancaria, l’affermazione della proprietà privata, l’assoggettamento delle banche a una più forte disciplina di mercato, anche con riguardo alla loro corporate governance.Le regole di Basilea producono distorsioni non meno serie di quelle attribuite alla precedente regolamentazione strutturale. La concorrenza eccessiva non è meno dannosa di un basso grado di concorrenza, l’impostazione del level playing field aiuta la grande dimensione e pratiche di too big to fail, i capital crunches producono seri effetti sull’economia, mentre i costi di regolamentazione assorbono importanti quote delle risorse delle banche minori. È materia di ulteriore ricerca verificare se la nuova impostazione di regolamentazione abbia anche favorito un aumento nella quota del reddito nazionale assorbito dal sistema finanziario senza aver prodotto una migliore distribuzione dei rischi e un proporzionale aumento in quella che James Tobin (1984 ha definito efficienza di piena assicurazione. At the national level, financial regulation based on prohibitions, the so-called structural rules, was accused of producing significant

  6. How changes in nutrition have influenced the development of allergic diseases in childhood

    Science.gov (United States)

    2012-01-01

    possono prevenire lo sviluppo di respiro sibilante (wheezing) attraverso i loro effetti antiossidanti contengono vitamina C e selenio; i livelli ematici di questi elementi sono correlati negativamente con il rischio di wheezing. Inoltre l'assunzione di vitamina E durante la gravidanza sembra essere correlato con un rischio ridotto di respiro sibilante per il nascituro. Allo stesso modo, basso apporto di zinco e di carotenoidi in donne in gravidanza è associata ad un aumentato rischio di wheezing e asma nell'infanzia. Anche le fibre hanno proprietà anti-infiammatorie ed effetti protettivi contro le malattie allergiche come la dermatite atopica e l’asma. Il consumo di grassi influenza lo sviluppo delle vie aeree. Le popolazioni dei paesi occidentali hanno aumentato il loro consumo di n-6 PUFA e, parallelamente, ridotto n-3 PUFA. Ciò ha portato alla diminuzione della produzione di PGE2, che si ritiene abbia un effetto protettivo contro l'infiammazione delle vie aeree. Ipotesi contrastanti riguardano la vitamina D, sia un eccesso che una carenza di vitamina D, infatti, sono stati associati ad un aumentato rischio di asma. Ulteriori studi sul ruolo di queste sostanze sono necessari prima di trarre conclusioni sul piano clinico. PMID:22651129

  7. LENDING IN FOREIGN CURRENCY AND CURRENT CHALLENGES AT EUROPEAN LEVEL

    Directory of Open Access Journals (Sweden)

    ȘARGU Alina Camelia

    2012-12-01

    Full Text Available In recent years, most countries in Central and Eastern Europe, Member States of the EU, that we selected for the analysis (Bulgaria, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania have recorded a significant expansion of lending in foreign currency, which was one of the major factors of the accelerated growth of loans to economy. Such developments have led to an increase of indebtedness in foreign currency of the non-financial private sector, especially of the households and of the accumulation of major macroeconomics and financial imbalances. The issue of lending in foreign currency, the determinants of increasing the share of loans in foreign currency and the risks generated at the level of financial stability are the subject of numerous studies, including: Basso, Calvo-Gonzales and Jurgilas (2007; Rosenberg and Tirpak (2008; Csajbók-Andras et al. (2010; Zettelmeyer, Nagy and Jeffrey (2010. Another significant issue addressed in the specialized literature regarding foreign currency loans refers to the role of monetary policy in limiting growth of these loans. Thus, in addition to those noted studies we remark other studies, such as: Kiss et al. (2006; Sirtaine and Skamnelos (2007; Hilbers et al. (2006; Brzoza-Brzezina et al. (2010. Our paper complements the specialized literature on the approached subject, in particular, by highlighting and discussing current issues of high interest for policymakers, both at national and European level regarding lending in foreign currency. The extremely negative implications of lending in foreign currency on financial stability in most countries under review, outlined clearly in the context of the current crisis, determined the focus of the policymakers concern, both at European and national level, regarding the issue of foreign currency loans, which became one of the most discussed issues on the agenda of the monetary-financial authorities. The aim of our research is to

  8. Perfil sociodemográfico del suicida en México de 1990 a 2011/Socio-demographic profile of suicide in Mexico from 1990 to 2011

    Directory of Open Access Journals (Sweden)

    Omar Alejandro De Léon Palomo

    2013-12-01

    Full Text Available Il suicidio è una condotta antisociale che si è imposta fin dall’inizio della storia dell’umanità. L’obiettivo di questa ricerca è quello di individuare i profili socio-demografici dei suicidi in Messico. I dati relativi ai suicidi verificatisi in Messico dal 1990 al 2011 sono stati ottenuti dall’Instituto Nacional de Estadística y Geografía (INEGI. Il profilo tracciato è il seguente: in Messico i suicidi vengono commessi da uomini (83,12%, aventi un’età compresa tra i 20 ed i 24 anni (16,85%, celibi (42,48%, con livello basso di scolarità (23,11%, occupati (64,17%. I suicidi si realizzano nella propria abitazione (68,2% ed i metodi comunemente più utilizzati sono l’impiccagione, lo strangolamento ed il soffocamento (75,08%. Questo profilo socio-demografico consente di mettere in evidenza alcuni elementi che influenzano tale comportamento antisociale e alcuni fattori di rischio suicidario nell’ambito della popolazione messicana, fornendo la possibilità di attivare adeguate misure preventive. Le suicide est un comportement antisocial qui a marqué l’histoire de l’humanité. L’objectif général de cette recherche était de dresser le profil sociodémographique du suicide au Mexique. Les données des suicides au Mexique entre 1990 et 2011 ont été obtenues de l’Institut National de Statistique et Géographie (INEGI. Le profil obtenu était : les suicides sont commis par des hommes (83,12%, âgés de 20 à 24 ans (16,85%, célibataires (42,48%, ayant un niveau d’éducation primaire (23,11%, qui travaillent (64,17%. Les suicides ont lieu à la maison (68,2% et les méthodes les plus couramment utilisées sont la pendaison, l’étranglement et l’étouffement (75,08%. Ce profil sociodémographique révèle des facteurs qui favorisent ce comportement antisocial et met en évidence certains facteurs de risque de commettre un suicide parmi la population mexicaine, permettant de prendre les mesures pr

  9. Heroe, Egregio, para contrabaixo e cravo: aspectos didáticos e interpretativos em uma transcrição de uma cantata do repertório colonial brasileiro Heroe, Egregio for double and harpsichord: interpretive and pedagogical aspects in a transcription of a cantata from the Brazilian colonial repertory

    Directory of Open Access Journals (Sweden)

    Fausto Borém

    2008-12-01

    (HIP, departing either from the adaptation of (aural and textual references already consolidated in the interpretation of the European repertoire or from the analysis of historical and formal elements and rhetorical figures. This article addresses these questions in Recitativo e Aria from the academic cantata Heroe, egregio, douto, peregrino (anonymous, Salvador, 1759 for soprano, two violins and basso continuo, transcribed for a solo orchestral string instrument (violin, viola, violoncello or double bass and harpsichord.

  10. Preserved processing of musical syntax in a person with agrammatic aphasia

    Directory of Open Access Journals (Sweden)

    Sadhvi Saxena

    2014-04-01

    Full Text Available A growing body of work suggests that processing hierarchical structure in language and in music rely on shared systems (review: Slevc, 2012, however this conclusion is tempered by neuropsychological dissociations between linguistic and musical processing (i.e., aphasia and amusia; review: Peretz, 2006. An influential reconciliation comes from Patel’s (2003 shared syntactic integration resource hypothesis (SSIRH, which suggests that evidence for shared processes reflect reliance on shared syntactic integration processes whereas dissociations result from damage to domain-specific syntactic representations. The SSIRH thus predicts that patients with deficits in the processing of linguistic syntax–such as agrammatic aphasics–should show parallel deficits in musical structural (harmonic processing. This prediction is countered by findings of impaired harmonic processing in patients with (apparently spared linguistic syntactic processing (e.g., Sammler et al., 2011, however evidence for the opposite dissociation–preserved harmonic processing in agrammatic aphasia–is lacking. While there are reports of preserved musical abilities despite global aphasia (Basso & Capitani, 1985 or severe Wernicke’s aphasia (Luria, Tsvetkova, & Futer, 1965, of preserved reading and writing of music in the face of alexia and agraphia (Signoret et al., 1987, and of preserved musical sound naming in the face of severe anomia (Tzortzis et al., 2000, no study (to our knowledge has demonstrated preserved musical structural processing in an agrammatic patient. In addition, at least one group of agrammatic aphasics did not show normal effects of harmonic priming, and showed a relationship between accuracy on acceptability judgments in language and in music (Patel et al., 2008. Here, we report a detailed analysis of structural processing in language and in music in HV, a 63 year-old native English-speaking female musician who sustained a left peri-Sylvian stroke. She

  11. I mammiferi dell'area di Capo Feto (Trapani

    Directory of Open Access Journals (Sweden)

    Massimiliano Di Vittorio

    2003-10-01

    Full Text Available Nel contesto del Progetto di riqualificazione ambientale del territorio di Capo Feto, area SIC della Provincia di Trapani si è proceduto allo studio della comunità di mammiferi dell?area. Sono state in tal modo scelte, in base alle loro caratteristiche ambientali, tre aree campione omogenee. L?attività di censimento e trappolamento si è protratta per tre diversi periodi stagionali (dal 22 al 27/10/2001, dal 19 al 24/03/2002 e dal 21 al 26/08/2002 per un totale, per ogni periodo, di 6 giorni e 5 notti trappola. Gli animali catturati sono stati registrati in apposite schede e pesati. Sono stati riportati il sesso e le condizioni riproduttive (giovane, adulto, adulto riproduttore etc. e gli individui sono stati marcati attraverso un piccolo taglio alle orecchie, attraverso un codice di riconoscimento determinato a priori. Riguardo i micromammiferi si è effettuato un rilevamento quantitativo, attraverso la tecnica del trappolamento MCR (Cattura-marcaggio-ricattura. Sono state utilizzate 100 trappole incruente cosiddette di ?cattura e ricattura? (Ugglan modell 1, di dimensioni 250x78x65 mm. Per i mammiferi di media taglia, si è proceduto (nelle varie tipologie ambientali con censimenti condotti di giorno e di notte (in cui tali specie mostrano maggiore attività con l?ausilio di fari e di appositi visori per l?impiego notturno, ed attraverso rilevamenti diretti (OD: osservazione individui, esemplari rinvenuti morti ed indiretti (OI: tracce, tane, resti ossei in borre, escrementi. Tenendo conto del basso numero di ricatture (in qualche caso uguali a zero, è stato usato l?indice di Chapman, adatto a piccoli campioni. Inoltre i dati ottenuti sono stati elaborati mediante l?indice DAT, che esprime una frequenza relativa per ogni ambiente analizzato. Per la comparazione tra i risultati (a livello di specie catturate dei tre periodi si è utilizzato il valore medio dell?Indice di somiglianza (S di Sorensen. I risultati dell?intero periodo di

  12. Scelta dell'habitat del tasso (Meles meles in un'area dell'Oltrepò pavese

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    Valentina Rigo

    2003-10-01

    .f.=1; p<0.001 e siti che presentino, nelle vicinanze, la presenza di castagne: risorsa trofica importante per l'animale (Χ²=6.220; d.f.=1; p=0.013. A differenza di quanto emerso in altre ricerche, il substrato geo-litologico e la distanza dai corsi d'acqua non risultano parametri statisticamente significativi, mentre un basso sviluppo delle strade, che rappresentano un disturbo ed un reale pericolo per i tassi, caratterizza i luoghi scelti per le tane. L'animale sembra prediligere, per le proprie tane, secondo quanto emerge anche dall'analisi multivariata, luoghi con un minore disturbo antropico. In conclusione, il tipo di ambiente, la copertura arborea e arbustiva, l'esposizione dei versanti, la presenza di adeguate risorse trofiche nelle vicinanze, la lontananza da strade e lo sviluppo dei centri abitati sono componenti che influenzano significativamente la presenza del tasso. Fattori geologici, litologici, e idrogeologici sono invece di scarsa importanza nell'area considerata.

  13. How changes in nutrition have influenced the development of allergic diseases in childhood

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    Peroni Diego G

    2012-05-01

    correlati. Gli alimenti che possono prevenire lo sviluppo di respiro sibilante (wheezing attraverso i loro effetti antiossidanti contengono vitamina C e selenio; i livelli ematici di questi elementi sono correlati negativamente con il rischio di wheezing. Inoltre l'assunzione di vitamina E durante la gravidanza sembra essere correlato con un rischio ridotto di respiro sibilante per il nascituro. Allo stesso modo, basso apporto di zinco e di carotenoidi in donne in gravidanza è associata ad un aumentato rischio di wheezing e asma nell'infanzia. Anche le fibre hanno proprietà anti-infiammatorie ed effetti protettivi contro le malattie allergiche come la dermatite atopica e l’asma. Il consumo di grassi influenza lo sviluppo delle vie aeree. Le popolazioni dei paesi occidentali hanno aumentato il loro consumo di n-6 PUFA e, parallelamente, ridotto n-3 PUFA. Ciò ha portato alla diminuzione della produzione di PGE2, che si ritiene abbia un effetto protettivo contro l'infiammazione delle vie aeree. Ipotesi contrastanti riguardano la vitamina D, sia un eccesso che una carenza di vitamina D, infatti, sono stati associati ad un aumentato rischio di asma. Ulteriori studi sul ruolo di queste sostanze sono necessari prima di trarre conclusioni sul piano clinico.

  14. Il rifornimento della rete commerciale al dettaglio della Provincia di Napoli

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    Marino de Luca

    2010-07-01

    Napoli città, il 41% dal resto della provincia e il 6% dal resto della regione Campania: solo il 19% proviene dal resto d’Italia e, in larga prevalenza, dal centro-nord. Si prevede che transitino per gli interporti dell’area solo i flussi extra campani mentre buona parte dei flussi con provenienze regionali può avvalersi dei transit-point di secondo livello dai quali, mediante carrelli a mano o elettrici o piccole vetture a basso impatto ambientale, nell’arco della giornata di arrivo, raggiungono i destinatari. Oltre alle verifiche di natura trasportistica finalizzate a valutare i costi del nuovo modello di assetto, sono state condotte altre verifiche con riferimento all’inserimento urbanistico ed alle soluzioni progettuali per i transit-point. Queste ultime sono state sviluppate scegliendo sei casi pilota che fossero, nei limiti del possibile, rappresentativi dei diversi contesti rinvenibile nell’area metropolitana. È stato così possibile procedere ad un dimensionamento delle superfici necessarie e definire i requisiti funzionali, tecnologici, ambientali ed economici per tre casi dei sei casi sviluppando schemi di progetto che ne dimostrano la possibilità di inserirsi nei contesti reali. Per quanto riguarda i costi si è giunti alla conclusione che il passaggio delle merci attraverso i transit-point comporta costi aggiuntivi che, essendo contenuti, dovrebbero poter essere compensati da benefici sociali e quindi dall’accollo da parte della Pubblica amministrazione di un’aliquota degli oneri aggiuntivi.

  15. Magma Mixing: Why Picrites are Not So Hot

    Science.gov (United States)

    Natland, J. H.

    2010-12-01

    porosity in regions where crustal-level magma chambers and flanking rift zones do not have a chance to form. Low-magma supply is favored. In the ocean basins, such upper mantle mainlining occurs only at certain fracture zones, deep propagating rifts at microplates, or ultra-slow spreading ridges, but no liquids (glasses) with >10% MgO occur at any of these places. On continents, rift structures through cratons might allow this, but so far no picrite, ferropicrite, or meimichite that has been adequately described from these places lacks evidence for end-member mixing. Low-temperature iron-rich magmas can accumulate in the deep lower crust and later rise to form substantial intrusions (e.g. Skaergaard) or erupt as flood basalts (Columbia River). Some komatiites might represent high-temperature liquids, but many are so altered that original liquid compositions cannot be deduced (e.g., Gorgona). The hottest intraplate volcano is Kilauea, Hawaii, where rare picrite glass with 15% MgO has an estimated eruptive temperature (1) of ~1350C and a potential temperature at 1 GPa of ~1420C. Lavas at all other linear island chains, Iceland and even west Greenland where picrites are abundant, are cooler than this. (1) Beattie, P., 1993. CMP 115: 103-111.

  16. Book Reviews

    Directory of Open Access Journals (Sweden)

    Christine Oppong

    1977-01-01

    Full Text Available - P. van de Velde, Chester G. Starr, Early man - Prehistory and the civilizations of the ancient near east. New York, London, Toronto, Oxford University Press, 1973. 7 + 205 pp., num. ill. black and white colour. - H. Hoetink, Ashley Montagu, Man’s most dangerous myth: the fallacy of race. New York, Oxford University Press, 1974, 5th edition, 542 pp. - J. Tennekes, Margaret T. Hodgen, Anthropology, history and cultural change. Viking Fund Publications in Anthropology, number 52. The University of Arizona Press, pp. 108, 1974. - H.J.M. Claessen, Regna Darnell, Readings in the history of anthropology. New York etc., Harper & Row, 1974. 479 pp. - John Beattie, F. Allan Hanson, Meaning in culture. London and Boston: Routledge & Kegan Paul (International Library of Anthropology, 1975. xi, 127 pp., bibl. - J. van Baal, Dan Sperber, Le symbolisme en général. Collection Savoir, Hermann, Paris, 1974. 163 pp. - David S. Moyer, Claude Levi-Strauss, La Voie des Masques. Les Sentiers de la Création, Editions d’art Albert Skira, Genève, 1975. Vol I, 142 pp. and vol. II, 147 pp. Figs., maps, colour plates. - W.C. Ultee, Suzanne Petra Schad, Empirical social research in Weimar-Germany. Mouton, Paris-The Hague, 1972. 155 pp. - C.J.J. Vermeulen, Paul-Henry Stahl, Ethnologie de l’Europe du Sud-est. Une anthologie. Mouton Éditeur, Paris/La Haye 1974. 312 p. - C.J.J. Vermeulen, Juliet du Boulay, Portrait of a Greek mountain village. Oxford monographs on social anthropology. Clarendon Press, Oxford 1974. viii, 296 pp., photogr. - Lodewijk Brunt, Jacob Black-Michaud, Cohesive force. Fued in the Mediterranean andthe Middle East. Oxford: Basil Blackwell 1975. With a foreword by E.L. Peters. 270 pp. - J.H. van den Brink, D’arcy McNickle, Native American Tribalism - Indian survivals and renewals. Oxford University Press, New York, London, 1973. 190 pp., geïll. - Sjaak van der Geest, Christine Oppong, Marriage among a matrilineal elite. A family

  17. Development of Research Infrastructure in Nevada for the Exploitation of Hyperspectral Image Data to Address Proliferation and Detection of Chemical and Biological Materials

    International Nuclear Information System (INIS)

    James V. Taranik

    2007-01-01

    research determined that spectral resolution of 10um was adequate, but a signal to noise above 300:1 was desirable for hyperspectral sensors with this spectral resolution. Finally, we acquired a hyperspectral thermal dataset (SEBASS) at 3m spatial resolution over our study area in Beatty, Nevada that can be co-registered with the hyperspectral reflectance, LIDAR and digital Orthophoto data sets. This data set will enable us to quantify how measurements in the reflected infrared can be used to make inferences about the response of materials in the thermal infrared, the topic of our follow-on NA-22 investigation ending in 2008. These data provide the basis for our investigations proposed for the NA-22 2008 Broad Area Announcement. Beginning in June 2008, SpecTIR Corporation and Aerospace Corporation plan to fly the SpecTIR Dual and SEBASS in a stabilized mount in a twin Otter aircraft. This research provides the foundation for using reflected and emitted hyperspectral measurements together for mapping geologic and soil materials in arid to semi-arid regions

  18. VA FitHeart, a Mobile App for Cardiac Rehabilitation: Usability Study.

    Science.gov (United States)

    Beatty, Alexis L; Magnusson, Sara L; Fortney, John C; Sayre, George G; Whooley, Mary A

    2018-01-15

    "), a desire for introductory training ("Initially, training with a technical person, instead of me relying on myself"), and an expectation for sharing data with providers ("It would also be helpful to share with my doctor, it just being a matter of clicking a button and sharing it with my doctor"). With participant feedback and iterative revisions, we significantly improved the usability of a mobile app for CR. Patient expectations for using a mobile app for CR include tracking health metrics, introductory training, and sharing data with providers. Iterative mixed-method evaluation may be useful for improving the usability of health technology. ©Alexis L Beatty, Sara L Magnusson, John C Fortney, George G Sayre, Mary A Whooley. Originally published in JMIR Human Factors (http://humanfactors.jmir.org), 15.01.2018.

  19. Book Reviews

    Directory of Open Access Journals (Sweden)

    John Beattie

    1967-01-01

    Baluba et de quelques autres peuplades dans le sud-est du Congo. Pontificia Universitas Gregoriana, Fribourg 1964, 49 pp. - K.A.H. Hidding, Armand Abel et al., Religions de Salut. Institut de sociologie, Université Libre de Bruxelles, 1962. 228 pp. - H.U.E. Thoden van Velzen, John Beattie, Other cultures; Aims, methods and achievements in social anthropology. Cohen & West. London 1964, xii, 283 pp., index. 32 sh. - A.A. Trouwborst, G.P. Murdock, Culture and society, twenty-four essays, University of Pittsburgh, 1965, XII, 376 pp. - C. Nooteboom, Carl A. Schmitz, Festschrift Alfred Bühler, herausgegeben von Carl A. Schmitz und Robert Wildhaber. Basler Beiträge zur Geographie und Ethnologie, Ethnologische Reihe, Band 2. Pharos Verlag Hans Rudolf Schwabe A.G., Basel, 1965. 465 S., 93 Abb., Robert Wildhaber (eds. - H.A. van Oort, Michael Banton, The social anthropology of complex societies. A.S.A. Monographs 4, Tavistock Publications. London. 1966, pp. xli, 156. - J.W. Minderhout, P. Gregorius, Sociologie van de niet-Westerse volken: verwantschap en huwelijk. Prisma-Compendia 17, Specturm, Utrecht/Antwerpen 1965. 267 p. - K. Kortmulder, Peter Weidkuhn, Aggressivität Ritus Säkularisierung; Biologische Grundformen religiöser Prozesse. Basler Beitr. zur Ethnol. und Geographie, Ethn. Reihe, Band 3. Pharos-Verlag, Basel 1965. 143 pp.

  20. Adaptation response surfaces from an ensemble of wheat projections under climate change in Europe

    Science.gov (United States)

    Ruiz-Ramos, Margarita; Ferrise, Roberto

    2016-04-01

    preliminary ARSs show some adaptation options allow recover up to ca. 2000 kg/ha. Compared to the historical yields recorded at Lleida province (2550 kg/ha in 1981-2010) our results indicate that adaptation is feasible and may help to reduce detrimental effects of CC. Our analysis evaluates if the explored adaptations fulfill the biophysical requirements to become a practical adaptive solution. This study exemplifies how adaptation options and their impacts can be analyzed, evaluated and communicated in a context of high regional uncertainty for current and future conditions and for short to long-term perspective. This work was funded by MACSUR project within FACCE-JPI. References Abeledo, L.G., R. Savin and G.A. Slafer (2008). European Journal of Agronomy 28:541-550. Cartelle, J., A. Pedró, R. Savin, G.A. Slafer (2006) European Journal of Agronomy 25:365-371. Pirttioja, N., T. Carter, S. Fronzek, M. Bindi, H. Hoffmann, T. Palosuo, M. Ruiz-Ramos, F. Tao, M. Acutis, S. Asseng, P. Baranowski, B. Basso, P. Bodin, S. Buis, D. Cammarano, P. Deligios, M.-F. Destain, B. Dumont, R. Ewert, R. Ferrise, L. François, T. Gaiser, P. Hlavinka, I. Jacquemin, K.C. Kersebaum, C. Kollas, J. Krzyszczak, I.J. Lorite, J. Minet, M.I. Minguez, M. Montesino, M. Moriondo, C. Müller, C. Nendel, I. Öztürk, A. Perego, A. Rodríguez, A.C. Ruane, F. Ruget, M. Sanna, M.A. Semenov, C. Slawinski, P. Stratonovitch, I. Supit, K. Waha, E. Wang, L. Wu, Z. Zhao, and R.P. Rötter, 2015: A crop model ensemble analysis of temperature and precipitation effects on wheat yield across a European transect using impact response surfaces. Clim. Res., 65, 87-105, doi:10.3354/cr01322. IRS2 TEAM: Alfredo Rodríguez(1), Ignacio J. Lorite(3), Fulu Tao(4), Nina Pirttioja(5), Stefan Fronzek(5), Taru Palosuo(4), Timothy R. Carter(5), Marco Bindi(2), Jukka G Höhn(4), Kurt Christian Kersebaum(6), Miroslav Trnka(7,8), Holger Hoffmann(9), Piotr Baranowski(10), Samuel Buis(11), Davide Cammarano(12), Yi Chen(13,4), Paola Deligios

  1. Hikikomori. La solitudine degli adolescenti giapponesi / Hikikomori. La solitude des adolescents japonais Hikikomori / Japanese teenagers’ loneliness

    Directory of Open Access Journals (Sweden)

    Moretti S.

    2010-12-01

    Full Text Available Il Giappone oggi rappresenta la terza potenza economica mondiale in cui il costo della vita è alto, il tasso di natalità basso e le patologie psichiche derivate da stress sono in forte aumento. Allarmante è il fenomeno hikikomori, una volontaria e ostinata forma di “ritiro sociale” (social withdrawal, di auto reclusione che si sviluppa nell’adolescenza e che nei casi più gravi dura anche più di dieci anni. L’eziologia del fenomeno è piuttosto complessa ma, tra le ipotesi plausibili avanzate, si parla di un disagio psichico dovuto ad una serie di fattori tra cui l’interdipendenza fra genitori e figli, la presenza di una figura materna iperprotettiva a fronte di un’assenza del padre e soprattutto il contesto sociale omologante, coartativo e frustrante. Si tratta di elementi in grado di generare nell’adolescente un angoscioso senso di inadeguatezza, alimentato dalla paura in cui il confronto con l’altro diventa insostenibile ed il silenzio la sola forma di comunicazione. Un disagio relazionale che conta nel Paese del Sol Levante più di un milione di adolescenti, ma che va diffondendosi anche negli Stati Uniti e nel Nord Europa.Le Japon représente aujourd'hui la troisième puissance économique mondiale, où le coût de la vie est élevé, le taux de natalité bas et les pathologies psychiques causées par le stress en forte augmentation. Le phénomène de l’hikikomori, une forme volontaire et obstinée de "retrait social" (social withdrawal, devient de plus en plus alarmant. Il s’agit d’une auto-réclusion qui se développe dans l'adolescence et qui, dans les cas les plus graves, peut durer plus de dix ans. L’étiologie du phénomène est plutôt complexe mais, parmi les hypothèses plausibles avancées, l’on parle d’un trouble psychique du à une série de facteurs, parmi lesquels figurent l'interdépendance entre parents et enfants, la présence d'une figure maternelle hyper protectrice conjuguée à l

  2. Screening mammography interpretation test: more frequent mistakes; Laboratorio di radiologia-Modulo di senologia: errori piu' frequenti

    Energy Technology Data Exchange (ETDEWEB)

    Gozzi, Gino; Ganzetti, Alessandra [U.O. Radiologia P.O. Sant' Anna, Como (Italy); Martinoli, Carlo; Bacigalupo, Lorenzo [Genova Univ., Genova (Italy). U.O. Radiologia Clinica; Conti, Giovanni Maria [Istituto di Radiologia Ospedali Riuniti, Parma (Italy); Bodini, Maria; Fiorentino, Carla; Marini, Ugo Paolo [P.O. Cremonese Azienda Istituti Ospedalieri, Cremona (Italy). Servizio di Radiologia; Santini, Dolores [Azienda USL Modena Poliambulatori Distretto 3, Modena (Italy). Screening Mammografico

    2005-03-01

    errate. Di queste 823 su 4288 risposte teoricamente attese negative (19,2%) sono risultate false positive, 357 su 1072 risposte teoricamente attese positive (33.3%) sono risultate false negative. Per quanto riguarda i 23 casi risultati piu' errati, erano rappresentati da 10/32 (31,25%) mammografie positive per patologia maligna e da 13/128 (10,15%) mammografie con patologia benigna o del tutto negative (Tab. I). Le 10 neoplasie comprendevano 7 carcinomi duttali infiltranti, 1 carcinoma cribriforme infiltrante, 1 carcinoma tubulare infiltrante, 1 carcinoma in situ. Le 13 mammografie risultate benigne all'esame cito-istologico o con follow-up prolungato (e considerate maligne dai partecipanti al test) corrispondevano a mastopatia fibroso cistica in 5 casi, esito cicatriziale di pregresso intervento in 1 caso, esito di ABBI in 1 caso, radial scar in 2 casi, microcalcificazioni stabili da anni in 2 casi, focolaio di scleroadenosi in 1 caso e focolaio di scleroelastosi in 1 caso. Conclusioni: L'errore e' stato determinato da: errore di analisi delle microcalcificazioni; patologia benigna simulante neoplasia; sovrapposizione di tessuto normale; visibilita' in una sola proiezione; localizzazione rispetto al corpus mammae; zone di asimmetria misconosciute. Va richiamata l'attenzione su questi aspetti semeiologici di patologia mammaria focale in quanto, opportunamente considerati, possono far diagnosticare precocemente carcinomi a basso grado con prognosi spesso favorevole.

  3. Geographical epidemiology of antibacterials in the preschool age

    Directory of Open Access Journals (Sweden)

    Cartabia Massimo

    2012-12-01

    permanent education activities. Moreover, the competent authorities should increasing their efforts to limit unnecessary prescriptions and increase appropriateness of prescribing. Riassunto Introduzione Le mappe tematiche consentono una più rapida ed immediata lettura delle differenze geografiche nella distribuzione di dati riferiti ad un territorio specifico. Lo scopo dello studio è mostrare, per la prima volta, l’applicazione di alcuni strumenti statistici e cartografici, nell’analisi dell’uso dei farmaci nella popolazione pediatrica di una regione italiana e valutare le differenze intra-regionali. Metodi Per valutare il tipo di distribuzione geografica delle prescrizioni, sono stati calcolati i tassi di prevalenza standardizzati (punteggi-z a livello di ASL, Distretti Sanitari e Comuni. Per valutare la correlazione con le ospedalizzazioni è stato usato il coefficiente di correlazione di Pearson; per valutare l’esistenza di autocorrelazione spaziale è stato usato l’indice I di Moran. Tramite l’uso della statistica G di Getis-Ord sono stati identificati cluster di aree ad alto e basso livello di prevalenza. Infine con un modello di regressione logistica è stata stimata la probabilità di ricevere almeno una prescrizione nel corso dell’anno per tutti i pazienti inclusi nello studio. Risultati Con l’uso delle mappe è possibile vedere che le prescrizioni non sono correlate con lo stato di salute della popolazione, ma sono correlate con l’attitudine prescrittiva del pediatra. Questo è confermato anche dal modello di regressione logistica costruito per stimare la probabilità di ricevere almeno una prescrizione considerando come variabili indipendenti l’età, il sesso, la prevalenza di ricoveri nel distretto di residenza, l’attitudine prescrittiva del pediatra, la classe di età del pediatra e la durata della convenzione del pediatra con l’Azienda Sanitaria Locale (ASL. Conclusioni Gli interventi primari per razionalizzare l’uso degli

  4. Environmental recovery of the Scoglio of S. Maria in Tropea (Southern Italy). A case of geologic and preservation normative in environmental wealth; Aspetti geologici e normativi del recupero conservativo dei beni ambientali culturali. Lo scoglio di Santa Maria dell'Isola di Tropea (Calabria)

    Energy Technology Data Exchange (ETDEWEB)

    Ietto, F. [Arcavacata Universita' della Calabria, Arcavacata, CS (Italy)

    2001-07-01

    limitate zone di particolare interesse per storia e tradizione. Di recente, la mutata sensibilita' verso i problemi ambientali, la quale non ne recepisce solo l'aspetto culturale, quanto anche i possibili vantaggi economici indotti da un loro recupero, sta promuovendo una serie d'interventi pubblici su tutto il territorio nazionale e in Calabria in particolare. Il recupero delle ricchezze ambientali richiede di norma l'utilizzo di diverse tecnologie con impatto ambientale basso o nullo. La scelta e l'organizzazione delle tecniche da adottare costituisce quindi un primo problema. Un secondo e' di tipo normativo, il quale guida l'intervento dalla progettazione all'appalto, all'esecuzione. Tale problema scaturisce dalla parziale attendibilita' delle previsioni di progetto rispetto alla realta', quale spesso si presenta in corso d'opera. Sovente, infatti, l'intensita' del degrado del bene oblitera quelle evidenze che possono rendere realmente esecutiva una progettazione. (abstract truncated)

  5. Selected Abstracts of the 20th National Congress of the Italian Society of Perinatal Medicine (Società Italiana di Medicina Perinatale, SIMP; Catania (Italy; March 22-24, 2018; Session “Prematurity”

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2018-03-01

    . PREDICTION OF PRETERM BIRTH IN MULTIPLE PREGNANCIES WITH SERIAL MEASUREMENTS OF CERVICAL LENGTH • G. Pavone, I. Faralli, A. Finelli, B. Matarrelli, D. Buca, M. Leombroni, C. CelentanoABS 17. PREGNANCY COMPLICATED BY GESTATIONAL DIABETES MELLITUS: IS PRETERM DELIVERY CORRELATED TO METFORMIN TREATMENT? • C. Callegari, P. Algeri, S. Di Nicola, I. Crippa, E.M. Mariani, I. Cameroni, P. Vergani, N. RoncagliaABS 18. MATERNAL HYPERTENSION AND SURVIVAL IN VERY PRETERM SINGLETONS AND TWINS: NOT JUST ONE ANSWER… • L. Gagliardi, O. BassoABS 19. CARDIOVASCULAR AND METABOLIC EF­FECTS OF HYDROCORTISONE THERAPY FOR BRONCHOPULMONARY DYSPLASIA IN PRETERM INFANTS • L. Antonini, A. Correani, L. Antognoli, I. Giretti, M. Maiorano, C. Rondina, V. CarnielliABS 20. DELIVERY AND NEONATAL OUTCOMES IN UNCOMPLICATED DICHORIONIC TWIN PREG­NANCIES ACCORDING TO MODE OF CON­CEPTION • P. Algeri, S. Ornaghi, I. Vaglio Tessitore, L. Brienza, S. Cozzolino, M. Incerti, P. VerganiABS 21. ROLE OF GROUP B STREPTOCOCCUS ON PERINATAL OUTCOME IN PREGNANCY COMPLICATED BY PRETERM DELIVERY < 34 WEEKS • F. Accordino, A. Griggio, S. Ornaghi, I. Cameroni, P. Vergani

  6. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    1994-01-01

    Leur. Hilversum: Verloren, 1992, 288 pp. - Jane A. Kusin, Brigit Obrist van Eeuwijk, Small but strong; Cultural context of (malnutrition among the Northern Kwanga (East Sepik province, Papua New Guinea. Basel: Wepf & Co. AG Verlag, Basler Beiträge zur ethnologie, Band 34, 1992, 283 pp. - J. Thomas Lindblad, Pasuk Phongpaichit, The new wave of Japanese investment in ASEAN. Singapore: Institute of Southeast Asian studies, 1990, 127 pp. - Niels Mulder, Louis Gabaude, Une herméneutique bouddhique contemporaine de Thaïlande; Buddhadasa Bhikku. Paris: École Francaise d’Extrême-Orient, 1988, vii + 692 pp. - Marleen Nolten, Vinson H. Sutlive. Jr., Female and male in Borneo; Contributions and challenges to gender studies. Borneo research council Monograph series, volume 1, not dated but probably published in 1991. - Ton Otto, G.W. Trompf, Melanesian Religion. Cambridge: Cambridge University Press, 1991, xi + 283 pp., including select bibliography and index. - IBM Dharma Palguna, Gordon D. Jensen, The Balinese people; A reinvestigation of character. Singapore-New York: Oxford University Press, 1992, 232 pp., Luh Ketut Suryani (eds. - Anton Ploeg, Jürg Schmid, Söhne des Krokodils; Männerhausrituale und initiation in Yensan, Zentral-Iatmul, East Sepik province, Papua New Guinea. Basel: ethnologisches seminar der Universitat und Musuem für Völkerkunde (Basler Beiträge zur ethnologie, band 36, 1992, xii + 321 pp., Christine Kocher Schmid (eds. - Raechelle Rubinstein, W. van der Molen, Javaans Schrift. (Semaian 8. Leiden: Vakgroep talen en culturen van Zuidoost-Azië en Oceanië, Rijksuniversiteit te Leiden, 1993. x + 129 pp. - Tine G. Ruiter, Arthur van Schaik, Colonial control and peasant resources in Java; Agricultural involution reconsidered. Amsterdam: Koninklijk Nederlands Aardrijkskundig Genootschap/Instituut voor Sociale geografie Universiteit van Amsterdam, 1986, 210 pp. - R. Schefold, Andrew Beatty, Society and exchange in Nias. Oxford: Clarendon press, (Oxford

  7. Comparison of the complete genome sequences of Pseudomonassyringae pv. syringae B728a and pv. tomato DC3000.

    Energy Technology Data Exchange (ETDEWEB)

    Feil, Helene; Feil, William S.; Chain, Patrick; Larimer, Frank; DiBartolo, Genevieve; Copeland, Alex; Lykidis, Athanasios; Trong,Stephen; Nolan, Matt; Goltsman, Eugene; Thiel, James; Malfatti,Stephanie; Loper, Joyce E.; Lapidus, Alla; Detter, John C.; Land, Miriam; Richardson, Paul M.; Kyrpides, Nikos C.; Ivanova, Natalia; Lindow, StevenE.

    2005-04-01

    producing avariety of different symptoms depending on the host species and site ofinfection. For example, it causes leaf spot diseases that defoliateplants such as tomato, bean, soybean, trunk cankers, and so-called"blast" diseases on fruit, nut and ornamental species. Considerablevariation occurs both between and within different pathovars of P.syringae (1). Because of its importance as a plant pathogen, it has beenthe subject of much research, especially of its epidemiology andvirulence mechanisms (2). Pseudomonas syringae pv. syringae (Pss) strainB728a is typical of most strains of this pathovar in that it exhibits avery pronounced epiphytic phase on plants. Such strains achieve andmaintain large populations on healthy plants, where they are exposed tostressful conditions such as dryness and sunlight that are hostile tobacterial growth(2). Epiphytic Pss populations serve as inocula that cansubsequently invade plants and initiate disease. Pss strains are distinctfrom many P. syringae strains, such as P. syringae pv. tomato (Pst)strain DC3000, that poorly colonize the exterior of plants; these strainsmay be considered "endophytes" based on their ability to multiply mostlywithin the plant (3). True epiphytes such as Pss B728a often reachsurface populations of over 107 cells/g while strains such as Pst DC3000seldom exceed 105 cells/g (2, 3). Thus, these strains might be consideredto occupy different ends of the epiphytic/endophytic spectrum of plantcolonization as described by Beattie and Lindow (4). As a pathogen and anepiphyte, Pss B728a has evolved to exploit at least two distincthabitats: the leaf surface and apoplast. Because rapid changes intemperature, low water content, and incident solar radiation occur onleaf surfaces, it has been hypothesized that the epiphyte Pss B728aposseses more genes conferring environmental stress tolerance than theendophyte Pst DC3000 (4). Pss B728a also exhibits several traits such asice nucleation activity and SR production (2) that are

  8. A revision of Metaleptobasis Calvert (Odonata: Coenagrionidae) with seven synonymies and the description of eighteen new species from South America.

    Science.gov (United States)

    Von Ellenrieder, Natalia

    2013-11-25

    . Beatty, A. Cordero & J. Hoffmann leg., in FSCA); M. longicauda (Holotype ♂, Brazil, Mato Grosso State, C. Teles Pires, Alto Tapajos, 1-31 viii 1956,  Sick leg., in MNRJ); M. orthogonia (Holotype ♂, Peru, Loreto Dep., San Juan, Río Amazonas, near Iquitos, viii 1939, J. Schunke leg., in FSCA); M. paludicola (Holotype ♂, Peru, Loreto Dep., Tamshiyacu-Tahuayo Reserve, swamp, 4°23'49''S, 73°14'57''W, 27 ii 2009, T. Faasen leg., in RMNH); M. panguanae (Holotype ♂, Peru, Huánuco Dep., Biological Station Panguana, E side Río Yuyapichis, 9°37'S, 74°57'W, 6-17 iv 2003, H.J. & E.-G. Burmeister leg., in ZSM); M. peltata (Holotype ♂, Peru Loreto Dep., Tamshiyacu-Tahuayo Reserve, 4°21'22''S, 73°11'0''W, 19 ii 2010, T. Faasen leg., in RMNH); M. prostrata (Holotype ♂, Peru, Junín Dep., Satipo, v 1945, P. Paprzycki leg., in UMMZ); M. silvicola (Holotype ♂, Peru, Madre de Dios Dep., Explorer's Inn on Río Tambopata, 30 km SW Puerto Maldonado, main trail, 1 viii 1979, M. Perkins & P. Donahue leg., in FSCA); M. spatulata (Holotype ♂, Peru, Huánuco Dep., 10 km N of Cucharas, confluence of Huallaga and Pacay rivers, viii 1954, F. Woytkowski leg., in UMMZ); M. tridentigera (Holotype ♂, Brazil, Rondônia State, Porto Velho, Area Abunan, T11 Aleatorio, 8°46'S, 63°54'W, 86 m, 16 v 2010, Nogueira & Mendes leg., in MZUSP); M. truncata (Holotype ♂, Brazil, Pará State, Jacareacanga, xi 1969, F.R. Barbosa leg., in UMMZ); and M. turbinata (Holotype ♂, Peru, Loreto Dep., Tamshiyacu-Tahuayo Reserve, forest swamp (4°24'18''S, 73°14'38''W), 25 ii 2010, T. Fassen leg., in RMNH). Illustrations, keys, diagnoses, and distribution maps for all 31 currently known species are provided. Phylogenetic relationships within the genus Metaleptobasis are analyzed based on 33 adult morphological characters, including the 31 currently described species of Metaleptobasis and eleven outgroup taxa of other Coenagrionidae of the subfamily Teinobasinae. The cladistic analysis recovered

  9. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2004-04-01

    Full Text Available -Timothy P. Barnard, Cynthia Chou, Indonesian sea nomads; Money, magic, and fear of the Orang Suku Laut. London: RoutledgeCurzon, 2003, xii + 159 pp. -R.H. Barnes, Toos van Dijk, Gouden eiland in de Bandazee; Socio-kosmische ideeën op Marsela, Maluku Tenggara, Indonesië. Leiden: Onderzoekschool voor Aziatische, Afrikaanse en Amerindische studies (CNWS, Universiteit Leiden, 2000, 458 pp. [CNWS Publications 94.] -Andrew Beatty, Peter G. Riddell, Islam and the Malay-Indonesian world; Transmission and responses. Honolulu: University of Hawai'i Press, 2001, xvii + 349 pp. -Peter Boomgaard, Richard H. Grove ,El Niño - history and crisis; Studies from the Asia-Pacific region. Cambridge: White Horse Press, 2000, 230 pp., John Chappell (eds -Bernardita Reyes Churchill, Florentino Rodao, Franco y el imperio japonés; Imágenes y propaganda en tiempos de guerra. Barcelona: Plaza and Janés, 2002, 669 pp. -Matthew Cohen, Stuart Robson, The Kraton; Selected essays on Javanese courts. Translated by Rosemary Robson-McKillop. Leiden: KITLV Press, 2003, xxvi + 397 pp. [Translation series 28.] -Serge Dunis, Ben Finney, Sailing in the wake of the ancestors; Reviving Polynesian voyaging. Honolulu: Bishop Museum Press, 2003, 176 pp. [Legacy of excellence.] -Heleen Gall, Jan A. Somers, De VOC als volkenrechtelijke actor. Deventer: Gouda Quint, Rotterdam: Sanders Instituut, 2001, x + 350 pp. -David Henley, Harold Brookfield, Exploring agrodiversity. New York: Columbia University Press, 2001, xix + 348 pp. -David Hicks, Ernst van Veen ,A guide to the sources of the history of Dutch-Portuguese relations in Asia (1594-1797. With a foreword by Leonard Blussé. Leiden: Institute for the history of European expansion, 2001, iv + 378 pp. [Intercontinenta 24.], Daniël Klijn (eds -Nico Kaptein, Donald J. Porter, Managing politics and Islam in Indonesia. London: RoutledgeCurzon, 2002, xxi + 264 pp. -Victor T. King, Monica Janowski, The forest, source of life; The Kelabit of

  10. Book Reviews

    Directory of Open Access Journals (Sweden)

    Heather Sutherland

    2000-10-01

    Full Text Available - Tim Behrend, Nancy K. Florida, Javanese literature in Surakarta manuscripts; Volume 2; Manuscripts of the Mangkunagaran palace. Ithaca, New York: Cornell University Southeast Asia Program, 2000, 575 pp. - Harold Brookfield, Judith M. Heimann, The most offending soul alive; Tom Harrisson and his remarkable life. Honolulu: University of Hawai’i Press, 1998, 468 pp. - Harold Brookfield, Victor T. King, Rural development and social science research; Case studies from Borneo. Phillips, Maine: Borneo Research Council, 1999, xiii + 359 pp. [Borneo Research Council Proceedings Series 6.] - J.G. de Casparis, Roy E. Jordaan, The Sailendras in Central Javanese history; A survey of research from 1950 to 1999. Yogyakarta: Penerbitan Universitas Sanata Dharma, 1999, iv + 108 pp. - H.J.M. Claessen, Francoise Douaire-Marsaudon, Les premiers fruits; Parenté, identité sexuelle et pouvoirs en Polynésie occidentale (Tonga, Wallis et Futuna. Paris: Éditions de la Maison des Sciences de l’Homme, 1998, x + 338 pp. - Matthew Isaac Cohen, Andrew Beatty, Varieties of Javanese religion; An anthropological account. Cambridge: Cambridge University Press, 1999, xv + 272 pp. [Cambridge Studies in Social and Cultural Anthropology 111.] - Matthew Isaac Cohen, Sylvia Tiwon, Breaking the spell; Colonialism and literary renaissance in Indonesia. Leiden: Department of Languages and Cultures of Southeast Asia and Oceania, University of Leiden, 1999, vi + 235 pp. [Semaian 18.] - Freek Colombijn, Victor T. King, Anthropology and development in South-East Asia; Theory and practice. Kuala Lumpur: Oxford University Press, 1999, xx + 308 pp. - Bernhard Dahm, Cive J. Christie, A modern history of South-East Asia; Decolonization, nationalism and seperatism. London: Tauris, 1996, x + 286 pp. - J. van Goor, Leonard Blussé, Pilgrims to the past; Private conversations with historians of European expansion. Leiden: Research School CNWS, 1996, 339 pp., Frans-Paul van der Putten, Hans

  11. Book Reviews

    Directory of Open Access Journals (Sweden)

    Peter Metcalf

    1990-10-01

    Full Text Available - M.A. van Bakel, R. Borofsky, Making history; Pukapukan and anthropological constructions of knowledge. Cambridge: Cambridge University Press, 1987. 201 pp.; ill. - Andrew Beatty, J.A. Feldman et al., Nias, tribal treasures: Cosmic reflections in stone, wood and gold, Delft: Volkenkundig Museum Nusantara, 1990. - A.G. van Beek, Christian F. Feest, Technologie und ergologie in der Völkerkunde, Band 2, Berlin: Dietrich Reimer Verlag, Ethnologische Paperbacks, 1989. xiv, 290 pp., Alfred Janata (eds. - N. Bootsma, Bernhard Dahm, José Rizal, Der nationalheld der Filipinos, Zürich: Munster-Schmidt Verlag Göttingen, 1988, 88 pp. - Aart G. Broek, John de Pool, Bolívar op / en Curaçoa: Historische novelle / leyende histórico [Inleiding door / introducción del L.W. Statius van Eps en / y E. Luckmann-Levy Maduro; vertaling uit het Spaans door L. Hoetink-Espinal], Zutphen: De Walburg Pers, 1988. - Martin van Bruinessen, Peter Kloos, Door het oog van de antropoloog: Botsende visies bij heronderzoek. Muiderberg: Dick Coutinho, 1988, 148 pp. - J.G. de Casparis, Charles Higham, The Archaeology of mainland Southeast Asia. From 10,000 B.C. to the fall of Angkor. Cambridge World Archaeology, Cambridge: Cambridge University Press, 1989. - H.J.M. Claessen, Luc de Heusch, Ecrits sur la royauté sacrée. Brussel, Institut de Sociologie: Editions de l’Université de Bruxelles. 1987. 314 pp. - H. Dagmar, Erich Kolig, The Noonkanbah Story, Dunedin: University of Otago Press, 1987. - Anke van Dijke, Linda Terpstra, Anil Ramdas, De strijd van de dansers; Biografische vertellingen uit Curaçao, Amsterdam: SUA, 1988. - B.F. Galjart, Hans-Dieter Evers, Strategische gruppen. Vergleichende studien zu staat, bürokratie und klassenbildung in der dritten welt. Berlin: Dietrich Reimer Verlag, 1988, 279 pp., Tilman Schiel (eds. - J. Hoffenaar, G. Teitler, Anatomie van de Indische defensie: Scenario’s, plannen, beleid 1892-1920. [Anatomy of the defence of the

  12. Sacral-neuromodulation CT-guided; Nuova tecnica di centraggio TC-assistista nella neuromodulazione sacrale

    Energy Technology Data Exchange (ETDEWEB)

    Amoroso, Lamberto; Ricci, Stefano [INRCA, Ancona (Italy). Dipartimento di radiologia e medicina nucleare; Pelliccioni, Giuseppe; Scarpino, Osvaldo [INRCA, Ancona (Italy). Unita' operativa di radiologia; Ghiselli, Roberto; Saba, Vittorio [INRCA, Ancona (Italy). Dipartimento di chirurgia

    2005-04-01

    total of 38 centering. Eight patients underwent the PNE procedure on both the S3 foramina. The sacral foramen was centred at the first attempt in 36 out of 38 cases. Two cases required several attempts to centre correctly the foramen. In 4 patients out of 30 a second electrode was implanted. In one patient who had a non consolidated sacral fracture, CT guidance enabled insertion of the electrode inside the only practicable foramen, a manoeuvre that would have been impossible with fluoroscopic guidance. Only once was repositioned after a CT control. During the whole trial period we had a positive response to the PNE test in 18 out of 30 patients (60%), a partial response in 4 out of 30 patients and a negative response in the remaining 8 patients. None of the patients who underwent the PNE test had infectious complications and the procedure was well tolerated by all. The procedure lasted about 45 minutes. Conclusions: The PNE test under Ct guidance proved to be more efficient compared with the traditional technique as the direct view of the electrode position helped to define with greater reliability the patients who were non-responsive to sacral stimulation. Moreover, this method was particularly efficient in patients with sacral anomalies where the traditional guide might fail. The operators' reduced exposure to radiation is an advantage to be taken into consideration. Finally, the usage of mobile CT apparatus in an operating theatre can improve the technique for permanent implantations. [Italian] Scopo: La neuromodulazione sacrale ? una nuova procedura diagnostico-terapeutica pe ri disturbi funzionali del basso tratto urinario come l'incontinenza urinaria da urgenza, la ritenzione urinaria non ostruttiva, la sindrome urgenza/frequenza, il dolore pelvico cronico intrattabile e, di recente, anche per il trattamento della stipsi e dell'incontinemza fecale. Il trattamento prevede una prima fase definita PNE test (Percutaneous Nerve Evaluation) che consiste

  13. Von der »Entstehung des öffentlichen Strafrechts« zur »Fabrikation des Verbrechens«

    Directory of Open Access Journals (Sweden)

    Karl Härter

    2002-01-01

    Full Text Available "Auss liebe der gerechtigkeit vnd umb gemeines nutz". Historische Beiträge zur Strafverfolgung, (Rothenburger Gespräche zur Strafrechtsgeschichte 1, hg. von GÜNTER JEROUSCHEK und HINRICH RÜPING, Tübingen: Edition Diskord 2000, 253 S., ISBN 3-89295-685-5. JOHN MAURICE BEATTIE, Policing and punishment in London, 1660-1750. Urban crime and the limits of terror, Oxford u. a.: Oxford University Press 2001, XIX, 491 p., ISBN 0-19-820867-7. ANDREAS BLAUERT, Das Urfehdewesen im deutschen Südwesten im Spätmittelalter und in der frühen Neuzeit, (Frühneuzeit-Forschungen 7, Tübingen: Bibliotheca-Academica-Verlag 2000, 199 S., ISBN 3-928471-25-2. ANDREAS BLAUERT, EVA WIEBEL, Gauner- und Diebslisten: Registrieren, Identifizieren und Fahnden im 18. Jahrhundert. Mit einem Repertorium gedruckter südwestdeutscher, schweizerischer und österreichischer Listen sowie einem Faksimile der Schäffer& Benedict Carpzov. Neue Perspektiven zu einem umstrittenen sächsischen Juristen, hg. von GÜNTER JEROUSCHEK, WOLFGANG SCHILD und WALTER GROPP, Tübingen: Ed. Diskord 2000, 320 S., ISBN 3-89295-695-2. The Civilization of Crime. Violence in Town and Country since the Middle Ages, ed. ERIC A. JOHNSON and ERIC H. MONKKONEN, Urbana/Chicago: University of Illinois Press 1996, 290 p., ISBN 0-252-02242-4. Criminalità e giustizia in Germania e in Italia. Pratiche giudiziarie e linguaggi giuridici tra tardo Medioevo ed età moderna / Kriminalität und Justiz in Deutschland und Italien. Rechtspraktiken und gerichtliche Diskurse in Spätmittelalter und Früher Neuzeit, hg. von MARCO BELLABARBA, GERD SCHWERHOFF und ANDREA ZORZI, (Annali dell& Denunziation und Justiz. Historische Dimensionen eines sozialen Phänomens, hg. von FRISO ROSS und ACHIM LANDWEHR, Tübingen: Ed. Diskord 2000, 283 S., ISBN 3-89295-689-8. Denunziation. Historische, juristische und psychologische Aspekte, hg. von GÜNTER JEROUSCHEK, INGE MARSSOLEK und HEDWIG RÖCKELEIN, (Forum Psychohistorie 7, T

  14. Proceedings of the International Cancer Imaging Society (ICIS 16th Annual Teaching Course

    Directory of Open Access Journals (Sweden)

    Dow-Mu Koh

    2016-10-01

    pseudopapillary tumour of pancreas: imaging features of a rare neoplasm KY Thein, CH Tan, YL Thian, CM Ho P7 MDCT - pathological correlation in colon adenocarcinoma staging: preliminary experience S De Luca, C Carrera, V Blanchet, L Alarcón, E Eyheremnedy P8 Image guided biopsy of thoracic masses and reduction of pneumothorax risk: 25 years experience B K Choudhury, K Bujarbarua, G Barman P9 Tumour heterogeneity analysis of 18F-FDG-PET for characterisation of malignant peripheral nerve sheath tumours in neurofibromatosis-1 GJ Cook, E Lovat, M Siddique, V Goh, R Ferner, VS Warbey P10 Impact of introduction of vacuum assisted excision (VAE on screen detected high risk breast lesions L Potti, B Kaye, A Beattie, K Dutton P11 Can we reduce prevalent recall rate in breast screening? AA Seth, F Constantinidis, H Dobson P12 How to reduce prevalent recall rate? Identifying mammographic lesions with low Positive Predictive Value (PPV AA Seth (archana.seth@nhs.net, F Constantinidis, H Dobson P13 Behaviour of untreated pulmonary thrombus in oncology patients diagnosed with incidental pulmonary embolism on CT R. Bradley, G. Bozas, G. Avery, A. Stephens, A. Maraveyas P14 A one-stop lymphoma biopsy service – is it possible? S Bhuva, CA Johnson, M Subesinghe, N Taylor P15 Changes in the new TNM classification for lung cancer (8th edition, effective January 2017 LE Quint, RM Reddy, GP Kalemkerian P16 Cancer immunotherapy: a review of adequate imaging assessment G González Zapico, E Gainza Jauregui, R Álvarez Francisco, S Ibáñez Alonso, I Tavera Bahillo, L Múgica Álvarez P17 Succinate dehydrogenase mutations and their associated tumours O Francies, R Wheeler, L Childs, A Adams, A Sahdev P18 Initial experience in the usefulness of dual energy technique in the abdomen SE De Luca, ME Casalini Vañek, MD Pascuzzi, T Gillanders, PM Ramos, EP Eyheremendy P19 Recognising the serious complication of Richter’s transformation in CLL patients C Stove, M Digby P20 Body diffusion-weighted MRI in

  15. Selected Abstracts of the 19th National Congress of the Italian Society of Perinatal Medicine (Società Italiana di Medicina Perinatale, SIMP; Naples (Italy; January 19-21, 2017

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-01-01

    . Giardina, M. Zamarra, L. Di Fabrizio, E. Laurenti, F. Bavetta, F. Pauselli, C. Antonelli, G.C. Di RenzoABS 20. DIFFERENT 3D TECHNIQUES IN THE STUDY OF FETAL CORPUS CALLOSUM AND ROLE OF 5D CNS PLUS • E. Salzano, G. Nazzaro, M. Miranda, T. Palmieri, R. Iazzetta, M. LocciABS 21. EVALUATION OF UTERINE ARTERIES DOPPLER AND ESTROGEN MILIEU IN OOCYTE DONATION PREGNANCIES • L. Mandia, P. Cavoretto, A. Inversetti, P. Duca, I. Cetin, V. SavasiABS 22. EVALUATION OF HORMONAL MILIEU IN THREE DIFFERENT MODE OF CONCEPTION • E. Grossi, L. Mandia, E. Gjoni, I. Cetin, V. SavasiABS 23. BREASTFEEDING: BIOLOGICAL AND SOCIAL VARIABLES COMPARED TO MODE OF CONCEPTION • P. Pileri, I. di Bartolo, T. Kind, I. Cetin, V. SavasiABS 24. LAPAROTOMIC MYOMECTOMY AT 18 WEEKS’ GESTATION DUE TO UTERINE FIBROID TORSION DURING PREGNANCY: A CASE WITH SUCCESSFUL SURGERY AND SPONTANEOUS VAGINAL DELIVERY AT TERM • A. Basso, M.R. Catalano, G. Loverro, S. Nocera, E. Di Naro, M.T. Loverro, M. Natrella, S.A. MastroliaABS 25. MALPERFUSION WITH EARLY DISTAL VILLOUS HYPOPLASIA: A HISTOLOGICAL LANDMARK OF THE GREAT OBSTETRICAL SYNDROMES • S.A. Mastrolia, L. Resta, A. Basso, M.R. Catalano, F.P. Bianchi, S. Tafuri, N. Laforgia, T.A. Florio, M. Loverro, A. Di Mauro, G. LoverroABS 26. FAILED VACUUM EXTRACTION – IS IT ASSOCIATED WITH LONG-TERM PEDIATRIC CARDIOVASCULAR, ENDOCRINE, AND INFECTIOUS MORBIDITY OF THE OFFSPRING? • S.A Mastrolia, A. Walfisch, T. Wainstock, D. Landau, E. SheinerABS 27. THE ASSOCIATION BETWEEN FAILED VACUUM AND LONG-TERM PEDIATRIC HEMATOLOGICAL MORBIDITY • S.A Mastrolia, A. Walfisch, T. Wainstock, D. Landau, E. SheinerABS 28. PERICONCEPTIONAL MATERNAL BIOMARKERS OF ONE-CARBON METABOLISM ARE ASSOCIATED WITH EMBRYONIC DEVELOPMENT ACCORDING TO THE CARNEGIE STAGES: THE ROTTERDAM PERICONCEPTIONAL COHORT (PREDICT STUDY • F. Parisi, M. Rousian, A.H.J. Koning, S.P. Willemsen, I. Cetin, R.P.M. Steegers-TheunissenABS 29. MATERNAL DIETARY PATTERNS AND HUMAN PRENATAL CEREBELLAR GROWTH: THE

  16. Selective Photonic Disinfection; A ray of hope in the war against pathogens

    Science.gov (United States)

    Tsen, Shaw-Wei D.; Tsen, Kong-Thon

    2016-06-01

    M 2008 Laser shock waves: fundamentals and applications 1st Int. Symp. On Laser Ultrasonics: Science, Technology and Applications (National Research Council of Canada, Montreal) paper 1 and references therein citation> 11 citation publication-type="other"> www.optics.rochester.edu/workgroups/boyd/assets/pdf/publications/nlomater.pdf citation> 12 citation publication-type="journal"> Cannon J L Papafragkou E Park G W Osborne J Jaykus L A Vinje J 2006 Surrogates for the study of norovirus stability and inactivation in the environment: a comparison of murine norovirus and feline calicivirus J. Food Prot. 69 2761 5 2761-5 citation> 13 citation publication-type="journal"> Tsen S W Wu T C Kiang J G Tsen K T 2012 Prospects for a novel ultrashort pulsed laser technology for pathogen inactivation J. Biomed. Sci. 19 62 10.1186/1423-0127-19-62 citation> 14 citation publication-type="journal"> Tsen S W Chapa T Beatty W Tsen K T Yu D Achilefu S 2012 Inactivation of enveloped virus by laser-driven protein aggregation J. Biomed. Opt. 17 128002 10.1117/1.JBO.17.12.128002 citation> 15 citation publication-type="journal"> Kattenhorn L M Mills R Wagner M Lomsadze A Makeev V Borodovsky M Ploegh H L Kessler B M 2004 Identification of proteins associated with murine cytomegalovirus virions J. Virol. 78 11187 11197 11187-97 10.1128/JVI.78.20.11187-11197.2004 citation> 16 citation publication-type="journal"> Rapp M Messerle M Buhler B Tannheimer M Keil G M Kosziniowski U H 1992 Identification of the murine cytomegalovirus glycoprotein B gene and its expression by recombinant vaccinia virus J. Virol. 66 4399 4406 4399-406 citation> 17 citation publication-type="journal"> Xu J Dallas P B Lyons P A Shellam G R Scalzo A A 1992 Identification of the glycoprotein H gene of murine cytomegalovirus J. Gen. Virol. 73 1849 1854 1849-54 10.1099/0022-1317-73-7-1849 citation> 18 citation publication-type="journal"> Scalzo A A Forbes C A Davis-Poynter N J Farrell H E Lyons P A 1995 DNA sequence and

  17. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Other”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    . Noditi, A. Gluhovschi, I. Enatescu, D. Anastasiu, D. Anastasiu, C. Dragomir, M. CrainaABS 32. PULSE OXIMETRY SCREENING IN COMMUNITY MIDWIFERY: ACCEPTABILITY OF MOTHERS AND COMMUNITY MIDWIVES • I.C. Narayen, N.A. Blom, M.S. Bourgonje-Verhart, C. Kolster-Bijdevaate, F. Posthumus, A.A. Kaptein, A.B. te PasABS 33. PERINATAL OUTCOME OF PREGNANCY WITHOUT ANTENATAL CARE • H. OrvosABS 34. DEVELOPMENT OF A TOOL TO CALCULATE NEONATAL INTENSIVE CARE COT AVAILABILITY • C. PetersABS 35. MONITORING HEART RATE IN PREMATURE INFANTS IMMEDIATELY AFTER BIRTH: PRELIMINARY RESULTS • S. Uslu, S. Sozeri, U. Zubarioglu, A. Bulbul, M. Dursun, E. TurkogluABS 36. PROVIDING IMMEDIATE NEONATAL CARE AND RESUSCITATION AT BIRTH BESIDE THE WOMAN: PARENTS’ VIEWS, A QUALITATIVE STUDY • A. Sawyer, S. Ayers, S. Bertullies, M. Thomas, A.D. Weeks, C.W. Yoxall, L. DuleyABS 37. TRANSITIONAL CARE ON THE POSTNATAL WARD – IS IT TIME FOR A CHANGE? • C. SullivanABS 38. MONITORING OF ANTENATAL STEROIDS, DELAYED CORD CLAMPING AND THERMOREGULATION (MASCoT • S. Mohamed Cassim, L. Beattie, C. Granger, D. AnandABS 39. FEASIBILITY OF AN AGE-APPROPRIATE ADDITION TO A PREVENTIVE POST-DISCHARGE INTERVENTION FOR VERY PRETERM TODDLERS; A PILOT STUDY • M. Flierman, K. Koldewijn, D. Meijssen, A. van Wassenaer-Leemhuis, C. Aarnoudse-Moens, P. van Schie, M. Jeukens-VisserABS 40. NEONATAL HEARING SCREENING: RESULTS IN TBILISI, GEORGIA • T. Devdariani, S. Japaridze, Z. KevanishviliABS 41. PROVIDING IMMEDIATE NEONATAL CARE AND RESUSCITATION AT BIRTH BESIDE THE WOMAN: CLINICIANS’ VIEWS, A QUALITATIVE STUDY • C.W. Yoxall, S. Ayers, A. Sawyer, S. Bertullies, M. Thomas, A.D. Weeks, L. DuleyABS 42. MORTALITY AND SERIOUS MORBIDITY RATES IN OUTBORN COMPARED WITH INBORN 22-27 WEEKS’ GESTATION INFANTS: A POPULATION-BASED STUDY • R. Boland, P. Davis, J. Dawson, L. DoyleABS 43. WELLBEING VERSUS BLOOD TESTING IN NEWBORNS ≥ 35 WEEKS’ GESTATION WITH RISK FACTORS OF EARLY ONSET SEPSIS: A HOSPITAL-BASED STUDY • A

  18. Obituary: Allan R. Sandage (1926-2010)

    Science.gov (United States)

    Devorkin, David

    2011-12-01

    a factor of two, which is a factor of eight in the volume and hence a factor of eight uncertainty in the densities in intergalactic space." [Interview of Bart Bok by David DeVorkin circa June 1978, AIP. www.aip.org/history/ohilist/] In 1961, Sandage's magisterial homage to his exemplar, The Hubble Atlas of Galaxies, became state of the art in the minds and hearts of young astronomers. "I have acted mainly as an editor," he claimed in his preface, "of a set of ideas and conclusions that were implicit" in Hubble's own unpublished notes, from the mind of the master. Intent upon finishing what Hubble had set out to do, Sandage ultimately surpassed him. With Gustav A. Tammann in 1981, he released a new reclassification and published it as the Revised Shapley-Ames Catalog, an achievement that Vera Rubin hailed as an "unsurpassed ... source of consistent morphological types for bright galaxies." [Vera Rubin, Bright Galaxies, Dark Matters, AIP, 1997, p. 90] In 1985, Sandage, with Tammann and R. Cadonau, reported that supernovae of Type 1A could be reliable indicators of distance over extragalactic scales, a new rung in the distance ladder that has proven to be immensely useful in recent decades. Sandage was also the first to isolate the optical spectrum of an enigmatic radio star, one of many sources in the Cambridge radio surveys now known as quasars that defied confirmation in the visible spectrum. He was not able to untangle the odd spectrum although he showed that its light intensity varied over relatively short time scales. Sandage symbolized the epitome of the classic optical astronomer. He relished long and frequent nights at the telescope, facing the heavens and its mysteries head on, once remarking that it was only in situ observing that provided the isolation and concentration that put his mind "in a state when its more receptive to call things up from its deep recesses." [Quoted in Kelly Beatty "Tribute to a Pioneering Cosmologist," S&T website November 15, 2010