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Sample records for based simultaneous component

  1. A structured overview of simultaneous component based data integration

    Directory of Open Access Journals (Sweden)

    van der Werf Mariët J

    2009-08-01

    Full Text Available Abstract Background Data integration is currently one of the main challenges in the biomedical sciences. Often different pieces of information are gathered on the same set of entities (e.g., tissues, culture samples, biomolecules with the different pieces stemming, for example, from different measurement techniques. This implies that more and more data appear that consist of two or more data arrays that have a shared mode. An integrative analysis of such coupled data should be based on a simultaneous analysis of all data arrays. In this respect, the family of simultaneous component methods (e.g., SUM-PCA, unrestricted PCovR, MFA, STATIS, and SCA-P is a natural choice. Yet, different simultaneous component methods may lead to quite different results. Results We offer a structured overview of simultaneous component methods that frames them in a principal components setting such that both the common core of the methods and the specific elements with regard to which they differ are highlighted. An overview of principles is given that may guide the data analyst in choosing an appropriate simultaneous component method. Several theoretical and practical issues are illustrated with an empirical example on metabolomics data for Escherichia coli as obtained with different analytical chemical measurement methods. Conclusion Of the aspects in which the simultaneous component methods differ, pre-processing and weighting are consequential. Especially, the type of weighting of the different matrices is essential for simultaneous component analysis. These types are shown to be linked to different specifications of the idea of a fair integration of the different coupled arrays.

  2. A flexible framework for sparse simultaneous component based data integration

    Directory of Open Access Journals (Sweden)

    Van Deun Katrijn

    2011-11-01

    Full Text Available Abstract 1 Background High throughput data are complex and methods that reveal structure underlying the data are most useful. Principal component analysis, frequently implemented as a singular value decomposition, is a popular technique in this respect. Nowadays often the challenge is to reveal structure in several sources of information (e.g., transcriptomics, proteomics that are available for the same biological entities under study. Simultaneous component methods are most promising in this respect. However, the interpretation of the principal and simultaneous components is often daunting because contributions of each of the biomolecules (transcripts, proteins have to be taken into account. 2 Results We propose a sparse simultaneous component method that makes many of the parameters redundant by shrinking them to zero. It includes principal component analysis, sparse principal component analysis, and ordinary simultaneous component analysis as special cases. Several penalties can be tuned that account in different ways for the block structure present in the integrated data. This yields known sparse approaches as the lasso, the ridge penalty, the elastic net, the group lasso, sparse group lasso, and elitist lasso. In addition, the algorithmic results can be easily transposed to the context of regression. Metabolomics data obtained with two measurement platforms for the same set of Escherichia coli samples are used to illustrate the proposed methodology and the properties of different penalties with respect to sparseness across and within data blocks. 3 Conclusion Sparse simultaneous component analysis is a useful method for data integration: First, simultaneous analyses of multiple blocks offer advantages over sequential and separate analyses and second, interpretation of the results is highly facilitated by their sparseness. The approach offered is flexible and allows to take the block structure in different ways into account. As such

  3. A flexible framework for sparse simultaneous component based data integration.

    Science.gov (United States)

    Van Deun, Katrijn; Wilderjans, Tom F; van den Berg, Robert A; Antoniadis, Anestis; Van Mechelen, Iven

    2011-11-15

    High throughput data are complex and methods that reveal structure underlying the data are most useful. Principal component analysis, frequently implemented as a singular value decomposition, is a popular technique in this respect. Nowadays often the challenge is to reveal structure in several sources of information (e.g., transcriptomics, proteomics) that are available for the same biological entities under study. Simultaneous component methods are most promising in this respect. However, the interpretation of the principal and simultaneous components is often daunting because contributions of each of the biomolecules (transcripts, proteins) have to be taken into account. We propose a sparse simultaneous component method that makes many of the parameters redundant by shrinking them to zero. It includes principal component analysis, sparse principal component analysis, and ordinary simultaneous component analysis as special cases. Several penalties can be tuned that account in different ways for the block structure present in the integrated data. This yields known sparse approaches as the lasso, the ridge penalty, the elastic net, the group lasso, sparse group lasso, and elitist lasso. In addition, the algorithmic results can be easily transposed to the context of regression. Metabolomics data obtained with two measurement platforms for the same set of Escherichia coli samples are used to illustrate the proposed methodology and the properties of different penalties with respect to sparseness across and within data blocks. Sparse simultaneous component analysis is a useful method for data integration: First, simultaneous analyses of multiple blocks offer advantages over sequential and separate analyses and second, interpretation of the results is highly facilitated by their sparseness. The approach offered is flexible and allows to take the block structure in different ways into account. As such, structures can be found that are exclusively tied to one data platform

  4. A flexible framework for sparse simultaneous component based data integration

    Science.gov (United States)

    2011-01-01

    1 Background High throughput data are complex and methods that reveal structure underlying the data are most useful. Principal component analysis, frequently implemented as a singular value decomposition, is a popular technique in this respect. Nowadays often the challenge is to reveal structure in several sources of information (e.g., transcriptomics, proteomics) that are available for the same biological entities under study. Simultaneous component methods are most promising in this respect. However, the interpretation of the principal and simultaneous components is often daunting because contributions of each of the biomolecules (transcripts, proteins) have to be taken into account. 2 Results We propose a sparse simultaneous component method that makes many of the parameters redundant by shrinking them to zero. It includes principal component analysis, sparse principal component analysis, and ordinary simultaneous component analysis as special cases. Several penalties can be tuned that account in different ways for the block structure present in the integrated data. This yields known sparse approaches as the lasso, the ridge penalty, the elastic net, the group lasso, sparse group lasso, and elitist lasso. In addition, the algorithmic results can be easily transposed to the context of regression. Metabolomics data obtained with two measurement platforms for the same set of Escherichia coli samples are used to illustrate the proposed methodology and the properties of different penalties with respect to sparseness across and within data blocks. 3 Conclusion Sparse simultaneous component analysis is a useful method for data integration: First, simultaneous analyses of multiple blocks offer advantages over sequential and separate analyses and second, interpretation of the results is highly facilitated by their sparseness. The approach offered is flexible and allows to take the block structure in different ways into account. As such, structures can be found that are

  5. [Quality evaluation of rhubarb dispensing granules based on multi-component simultaneous quantitative analysis and bioassay].

    Science.gov (United States)

    Tan, Peng; Zhang, Hai-Zhu; Zhang, Ding-Kun; Wu, Shan-Na; Niu, Ming; Wang, Jia-Bo; Xiao, Xiao-He

    2017-07-01

    This study attempts to evaluate the quality of Chinese formula granules by combined use of multi-component simultaneous quantitative analysis and bioassay. The rhubarb dispensing granules were used as the model drug for demonstrative study. The ultra-high performance liquid chromatography (UPLC) method was adopted for simultaneously quantitative determination of the 10 anthraquinone derivatives (such as aloe emodin-8-O-β-D-glucoside) in rhubarb dispensing granules; purgative biopotency of different batches of rhubarb dispensing granules was determined based on compound diphenoxylate tablets-induced mouse constipation model; blood activating biopotency of different batches of rhubarb dispensing granules was determined based on in vitro rat antiplatelet aggregation model; SPSS 22.0 statistical software was used for correlation analysis between 10 anthraquinone derivatives and purgative biopotency, blood activating biopotency. The results of multi-components simultaneous quantitative analysisshowed that there was a great difference in chemical characterizationand certain differences inpurgative biopotency and blood activating biopotency among 10 batches of rhubarb dispensing granules. The correlation analysis showed that the intensity of purgative biopotency was significantly correlated with the content of conjugated anthraquinone glycosides (Pquantitative analysis and bioassay can achieve objective quantification and more comprehensive reflection on overall quality difference among different batches of rhubarb dispensing granules. Copyright© by the Chinese Pharmaceutical Association.

  6. Scaling in ANOVA-simultaneous component analysis

    NARCIS (Netherlands)

    Timmerman, M.E; Hoefsloot, H.C.J.; Smilde, A.K.; Ceulemans, E.

    2015-01-01

    In omics research often high-dimensional data is collected according to an experimental design. Typically, the manipulations involved yield differential effects on subsets of variables. An effective approach to identify those effects is ANOVA-simultaneous component analysis (ASCA), which combines

  7. Simultaneous fingerprint, quantitative analysis and anti-oxidative based screening of components in Rhizoma Smilacis Glabrae using liquid chromatography coupled with Charged Aerosol and Coulometric array Detection.

    Science.gov (United States)

    Yang, Guang; Zhao, Xin; Wen, Jun; Zhou, Tingting; Fan, Guorong

    2017-04-01

    An analytical approach including fingerprint, quantitative analysis and rapid screening of anti-oxidative components was established and successfully applied for the comprehensive quality control of Rhizoma Smilacis Glabrae (RSG), a well-known Traditional Chinese Medicine with the homology of medicine and food. Thirteen components were tentatively identified based on their retention behavior, UV absorption and MS fragmentation patterns. Chemometric analysis based on coulmetric array data was performed to evaluate the similarity and variation between fifteen batches. Eight discriminating components were quantified using single-compound calibration. The unit responses of those components in coulmetric array detection were calculated and compared with those of several compounds reported to possess antioxidant activity, and four of them were tentatively identified as main contributors to the total anti-oxidative activity. The main advantage of the proposed approach was that it realized simultaneous fingerprint, quantitative analysis and screening of anti-oxidative components, providing comprehensive information for quality assessment of RSG. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Investigation of True High Frequency Electrical Substrates of fMRI-Based Resting State Networks Using Parallel Independent Component Analysis of Simultaneous EEG/fMRI Data

    Directory of Open Access Journals (Sweden)

    Sreenath P. Kyathanahally

    2017-12-01

    Full Text Available Previous work using simultaneously acquired electroencephalography (EEG and functional magnetic resonance imaging (fMRI data has shown that the slow temporal dynamics of resting state brain networks (RSNs, e.g., default mode network (DMN, visual network (VN, obtained from fMRI are correlated with smoothed and down sampled versions of various EEG features such as microstates and band-limited power envelopes. Therefore, even though the down sampled and smoothed envelope of EEG gamma band power is correlated with fMRI fluctuations in the RSNs, it does not mean that the electrical substrates of the RSNs fluctuate with periods <100 ms. Based on the scale free properties of EEG microstates and their correlation with resting state fMRI fluctuations in the RSNs, researchers have speculated that truly high frequency electrical substrates may exist for the RSNs, which would make resting fluctuations obtained from fMRI more meaningful to typically occurring fast neuronal processes in the sub-100 ms time scale. In this study, we test this critical hypothesis using an integrated framework involving simultaneous EEG/fMRI acquisition, fast fMRI sampling (TR = 200 ms using multiband EPI (MB EPI, and EEG/fMRI fusion using parallel independent component analysis (pICA which does not require the down sampling of EEG to fMRI temporal resolution. Our results demonstrate that with faster sampling, high frequency electrical substrates (fluctuating with periods <100 ms time scale of the RSNs can be observed. This provides a sounder neurophysiological basis for the RSNs.

  9. Simultaneous inference of a binary composite endpoint and its components

    DEFF Research Database (Denmark)

    Große Ruse, Mareile; Ritz, Christian; Hothorn, Ludwig A.

    2017-01-01

    Binary composite endpoints offer some advantages as a way to succinctly combine evidence from a number of related binary endpoints recorded in the same clinical trial into a single outcome. However, as some concerns about the clinical relevance as well as the interpretation of such composite...... endpoints have been raised, it is recommended to evaluate the composite endpoint jointly with the involved components. We propose an approach for carrying out simultaneous inference based on separate model fits for each endpoint, yet controlling the family-wise type I error rate asymptotically. The key idea......). The method is compared to the gatekeeping approach and results are provided in the Supplementary Material. In two data examples we show how the procedure may be adapted to handle local significance levels specified through a priori given weights....

  10. Investigation of True High Frequency Electrical Substrates of fMRI-Based Resting State Networks Using Parallel Independent Component Analysis of Simultaneous EEG/fMRI Data.

    Science.gov (United States)

    Kyathanahally, Sreenath P; Wang, Yun; Calhoun, Vince D; Deshpande, Gopikrishna

    2017-01-01

    Previous work using simultaneously acquired electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data has shown that the slow temporal dynamics of resting state brain networks (RSNs), e.g., default mode network (DMN), visual network (VN), obtained from fMRI are correlated with smoothed and down sampled versions of various EEG features such as microstates and band-limited power envelopes. Therefore, even though the down sampled and smoothed envelope of EEG gamma band power is correlated with fMRI fluctuations in the RSNs, it does not mean that the electrical substrates of the RSNs fluctuate with periods state fMRI fluctuations in the RSNs, researchers have speculated that truly high frequency electrical substrates may exist for the RSNs, which would make resting fluctuations obtained from fMRI more meaningful to typically occurring fast neuronal processes in the sub-100 ms time scale. In this study, we test this critical hypothesis using an integrated framework involving simultaneous EEG/fMRI acquisition, fast fMRI sampling ( TR = 200 ms) using multiband EPI (MB EPI), and EEG/fMRI fusion using parallel independent component analysis (pICA) which does not require the down sampling of EEG to fMRI temporal resolution . Our results demonstrate that with faster sampling, high frequency electrical substrates (fluctuating with periods <100 ms time scale) of the RSNs can be observed. This provides a sounder neurophysiological basis for the RSNs.

  11. A clusterwise simultaneous component method for capturing within-cluster differences in component variances and correlations

    NARCIS (Netherlands)

    De Roover, Kim; Ceulemans, Eva; Timmerman, Marieke E.; Onghena, Patrick

    This paper presents a clusterwise simultaneous component analysis for tracing structural differences and similarities between data of different groups of subjects. This model partitions the groups into a number of clusters according to the covariance structure of the data of each group and performs

  12. Investigation of True High Frequency Electrical Substrates of fMRI-Based Resting State Networks Using Parallel Independent Component Analysis of Simultaneous EEG/fMRI Data

    OpenAIRE

    Sreenath P. Kyathanahally; Sreenath P. Kyathanahally; Yun Wang; Yun Wang; Vince D. Calhoun; Vince D. Calhoun; Gopikrishna Deshpande; Gopikrishna Deshpande; Gopikrishna Deshpande

    2017-01-01

    Previous work using simultaneously acquired electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data has shown that the slow temporal dynamics of resting state brain networks (RSNs), e.g., default mode network (DMN), visual network (VN), obtained from fMRI are correlated with smoothed and down sampled versions of various EEG features such as microstates and band-limited power envelopes. Therefore, even though the down sampled and smoothed envelope of EEG gamma band p...

  13. A very fast algorithm for simultaneously performing connected-component labeling and euler number computing.

    Science.gov (United States)

    He, Lifeng; Chao, Yuyan

    2015-09-01

    Labeling connected components and calculating the Euler number in a binary image are two fundamental processes for computer vision and pattern recognition. This paper presents an ingenious method for identifying a hole in a binary image in the first scan of connected-component labeling. Our algorithm can perform connected component labeling and Euler number computing simultaneously, and it can also calculate the connected component (object) number and the hole number efficiently. The additional cost for calculating the hole number is only O(H) , where H is the hole number in the image. Our algorithm can be implemented almost in the same way as a conventional equivalent-label-set-based connected-component labeling algorithm. We prove the correctness of our algorithm and use experimental results for various kinds of images to demonstrate the power of our algorithm.

  14. Component Based Testing with ioco

    NARCIS (Netherlands)

    van der Bijl, H.M.; Rensink, Arend; Tretmans, G.J.

    Component based testing concerns the integration of components which have already been tested separately. We show that, with certain restrictions, the ioco-test theory for conformance testing is suitable for component based testing, in the sense that the integration of fully conformant components is

  15. Simultaneous refinement of two components of an exsolution intergrowth

    DEFF Research Database (Denmark)

    Topa, Dan; Petricek, Vaclav; Dusek, Michal

    2008-01-01

    Crystal structures of intergrown lindstromite and krupkaite were determined in two distinct samples by a simultaneous crystal-structure refinement using a modified JANA program package. The exsolution intergrowths have a bulk composition, determined by means of electron microprobe, equal to bd(60...

  16. Early Effect of Amyloid β-Peptide on Hippocampal and Serum Metabolism in Rats Studied by an Integrated Method of NMR-Based Metabolomics and ANOVA-Simultaneous Component Analysis

    Directory of Open Access Journals (Sweden)

    Yao Du

    2017-01-01

    Full Text Available Amyloid β (Aβ deposition has been implicated in the pathogenesis of Alzheimer’s disease. However, the early effect of Aβ deposition on metabolism remains unclear. In the present study, thus, we explored the metabolic changes in the hippocampus and serum during first 2 weeks of Aβ25–35 injection in rats by using an integrated method of NMR-based metabolomics and ANOVA-simultaneous component analysis (ASCA. Our results show that Aβ25–35 injection, time, and their interaction had statistically significant effects on the hippocampus and serum metabolome. Furthermore, we identified key metabolites that mainly contributed to these effects. After Aβ25–35 injection from 1 to 2 weeks, the levels of lactate, N-acetylaspartate, creatine, and taurine were decreased in rat hippocampus, while an increase in lactate and decreases in LDL/VLDL and glucose were observed in rat serum. Therefore, we suggest that the reduction in energy and lipid metabolism as well as an increase in anaerobic glycolysis may occur at the early stage of Aβ25–35 deposition.

  17. Simultaneous characterization of pancreatic stellate cells and other pancreatic components within three-dimensional tissue environment during chronic pancreatitis

    Science.gov (United States)

    Hu, Wenyan; Fu, Ling

    2013-05-01

    Pancreatic stellate cells (PSCs) and other pancreatic components that play a critical role in exocrine pancreatic diseases are generally identified separately by conventional studies, which provide indirect links between these components. Here, nonlinear optical microscopy was evaluated for simultaneous characterization of these components within a three-dimensional (3-D) tissue environment, primarily based on multichannel detection of intrinsic optical emissions and cell morphology. Fresh rat pancreatic tissues harvested at 1 day, 7 days, and 28 days after induction of chronic pancreatitis were imaged, respectively. PSCs, inflammatory cells, blood vessels, and collagen fibers were identified simultaneously. The PSCs at day 1 of chronic pancreatitis showed significant enlargement compared with those in normal pancreas (ppancreatic components coincidently within 3-D pancreatic tissues. It is a prospect for intravital observation of dynamic events under natural physiological conditions, and might help uncover the key mechanisms of exocrine pancreatic diseases, leading to more effective treatments.

  18. Continuous Fourier transform method and apparatus. [for the analysis of simultaneous analog signal components

    Science.gov (United States)

    Munoz, R. M. (Inventor)

    1974-01-01

    An input analog signal to be frequency analyzed is separated into N number of simultaneous analog signal components each identical to the original but delayed relative to the original by a successively larger time delay. The separated and delayed analog components are combined together in a suitable number of adders and attenuators in accordance with at least one component product of the continuous Fourier transform and analog signal matrices to separate the analog input signal into at least one of its continuous analog frequency components of bandwidth 1/N times the bandwidth of the original input signal. The original analog input signal can be reconstituted by combining the separate analog frequency components in accordance with the component products of the continuous Fourier transform and analog frequency component matrices. The continuous Fourier transformation is useful for spectrum analysis, filtering, transfer function synthesis, and communications.

  19. A novel GMO biosensor for rapid ultrasensitive and simultaneous detection of multiple DNA components in GMO products.

    Science.gov (United States)

    Huang, Lin; Zheng, Lei; Chen, Yinji; Xue, Feng; Cheng, Lin; Adeloju, Samuel B; Chen, Wei

    2015-04-15

    Since the introduction of genetically modified organisms (GMOs), there has been on-going and continuous concern and debates on the commercialization of products derived from GMOs. There is an urgent need for development of highly efficient analytical methods for rapid and high throughput screening of GMOs components, as required for appropriate labeling of GMO-derived foods, as well as for on-site inspection and import/export quarantine. In this study, we describe, for the first time, a multi-labeling based electrochemical biosensor for simultaneous detection of multiple DNA components of GMO products on the same sensing interface. Two-round signal amplification was applied by using both an exonuclease enzyme catalytic reaction and gold nanoparticle-based bio-barcode related strategies, respectively. Simultaneous multiple detections of different DNA components of GMOs were successfully achieved with satisfied sensitivity using this electrochemical biosensor. Furthermore, the robustness and effectiveness of the proposed approach was successfully demonstrated by application to various GMO products, including locally obtained and confirmed commercial GMO seeds and transgenetic plants. The proposed electrochemical biosensor demonstrated unique merits that promise to gain more interest in its use for rapid and on-site simultaneous multiple screening of different components of GMO products. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. A Study on the Simultaneous Multi-Components Analysis of Soil Pollution

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Kang-Sup; Kim, Kun-Han; Choi, Byung-In [Korea Institute of Geology Mining and Materials, Taejon (KR)] (and others)

    1999-12-01

    Dissolution properties for the several inorganic pollutants in soils have been studied and simultaneous multi-components analytical method has been established with using ICP/MS and LA-ICP/MS for 14 monitoring elements in order to protect water and soil environments. And addition, more effective new analytical methods have been studied for BTEX, TPH(total petroleum hydrocarbon) and organophosphorus compounds, PCBs in soils. Several inorganic pollutants were spiked to 3 kinds of fresh soils which were sand, clay, loam. The dissolution properties of the prepared samples were investigated under the various extracting conditions such as extracting time, acid concentration, particle size, etc. in order to take basic information about the process of extraction test and improvement of related analytical methods. As the results, dissolution properties were affected mainly by acid concentration in extracting procedure and mineral composition of soils. On the other hand, extracting time, sort of acids and particle size of soils had a little influence on the dissolution properties. Cd revealed very high dissolving efficiency and As was very low in whole extracting test. Current analytical methods for the determination of oils are based on the purge and trap for volatiles such as gasoline and solvent extraction for semivolatiles such as kerosene and diesel oils. These methods are not proper in cost and time. In addition to, there are potential for analyte contamination and some problems in pretreatment procedure. In this study, we have discussed simultaneous determination of TPH containing gasoline, kerosene, diesel oils and etc.. And determination of Organophosphorus compounds in soils has studied. In this procedure, the application of ultrasonication methods and several extraction methods were compared. In the results of this study, we could take very low practical detection limit and good precision. Approved methods were suitable for the determination of oils and pesticides

  1. Research on the simultaneous multi-components analytical method for polluted soil

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Kang Sup; Song, Duk Young; Choi, Byung In; Kim, Kun Han; Eum, Chul Hun; Jeon, Chi Wan; Lee, Jung Hwa [Korea Institute of Geology Mining and Materials, Taejon (Korea)

    1998-12-01

    Dissolution properties for the several inorganic pollutants in soils have been studied and simultaneous multi-components analytical method has been established with using ICP/MS for 13 monitoring elements in order to protect water and soil environments. And addition, more effective new analytical methods have been studied for TPH(total petroleum hydrocarbon) and organophosphorus compounds in soils. Several inorganic pollutants were spiked to 3 kinds of fresh soils which were sand, clay, loam. The dissolution properties of the prepared samples were investigated under the various extracting conditions such as extracting time, acid concentration, particle size, etc. in order to take basic information about the process of extraction test and improvement of related analytical methods. As the results, dissolution properties were affected mainly by acid concentration in extraction procedure and mineral composition of soils. On the other hand, extracting time, sort of acids and particle size of soils has a little influence on the dissolution properties. Cd revealed very high dissolving efficiency and As was very low in whole extracting test. Current analytical methods for the determination of soils are based on the purge and trap for volatiles such as gasoline and solvent extraction for semivolatiles such as kerosene and diesel oils. These methods are not proper in cost and time. In addition to, there are potential for analyte contamination and some problems in pretreatment procedure. In this study , we have discussed simultaneous determination of TPH containing gasoline, kerosene, diesel oils and etc. And determination of Organophosphorus compounds in soils has studied. In this procedure, the application of ultrasonication methods and several extraction methods were compared. In the results of this study, we could take very low practical detection limit and good precision. Approved methods were suitable for the determination of oils and pesticides in soil at high and low

  2. Novel methodologies for automatically and simultaneously determining BTEX components using FTIR spectra.

    Science.gov (United States)

    Wang, Liang; Liu, Erming; Cheng, Ying; Bekele, Dawit N; Lamb, Dane; Chen, Zuliang; Megharaj, Mallavarapu; Naidu, Ravendra

    2015-11-01

    This study introduced a patented novel methodological system for automatically analysis of Fourier Transform Infrared Spectrometer (FTIR) spectrum data located at 'fingerprint' region (wavenumber 670-800 cm(-1)), to simultaneously determinate multiple petroleum hydrocarbons (PHs) in real mixture samples. This system includes: an object oriented baseline correction; Band decomposition (curve fitting) method with mathematical optimization; and Artificial Neural Network (ANN) for determination, which is suitable for the characteristics of this IR regions, where the spectra are normally with low signal to noise ratio and high density of peaks. BTEX components are potentially lethal carcinogens and contained in many petroleum products. As a case study, six BTEX components were determinate automatically and simultaneously in mixture vapor samples. The robustness of the BTEX determination was validated using real petroleum samples, and the prediction results were compared with gas chromatography-mass spectrometry (GC-MS). Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Novel algorithm for simultaneous component detection and pseudo-molecular ion characterization in liquid chromatography–mass spectrometry

    International Nuclear Information System (INIS)

    Zhang, Yufeng; Wang, Xiaoan; Wo, Siukwan; Ho, Hingman; Han, Quanbin; Fan, Xiaohui; Zuo, Zhong

    2015-01-01

    Highlights: • Novel stepwise component detection algorithm (SCDA) for LC–MS datasets. • New isotopic distribution and adduct-ion models for mass spectra. • Automatic component classification based on adduct-ion and isotopic distributions. - Abstract: Resolving components and determining their pseudo-molecular ions (PMIs) are crucial steps in identifying complex herbal mixtures by liquid chromatography–mass spectrometry. To tackle such labor-intensive steps, we present here a novel algorithm for simultaneous detection of components and their PMIs. Our method consists of three steps: (1) obtaining a simplified dataset containing only mono-isotopic masses by removal of background noise and isotopic cluster ions based on the isotopic distribution model derived from all the reported natural compounds in dictionary of natural products; (2) stepwise resolving and removing all features of the highest abundant component from current simplified dataset and calculating PMI of each component according to an adduct-ion model, in which all non-fragment ions in a mass spectrum are considered as PMI plus one or several neutral species; (3) visual classification of detected components by principal component analysis (PCA) to exclude possible non-natural compounds (such as pharmaceutical excipients). This algorithm has been successfully applied to a standard mixture and three herbal extract/preparations. It indicated that our algorithm could detect components’ features as a whole and report their PMI with an accuracy of more than 98%. Furthermore, components originated from excipients/contaminants could be easily separated from those natural components in the bi-plots of PCA

  4. Novel algorithm for simultaneous component detection and pseudo-molecular ion characterization in liquid chromatography–mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yufeng; Wang, Xiaoan; Wo, Siukwan [School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong (China); Ho, Hingman; Han, Quanbin [School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong (China); Fan, Xiaohui [College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058 (China); Zuo, Zhong, E-mail: joanzuo@cuhk.edu.hk [School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong (China)

    2015-01-01

    Highlights: • Novel stepwise component detection algorithm (SCDA) for LC–MS datasets. • New isotopic distribution and adduct-ion models for mass spectra. • Automatic component classification based on adduct-ion and isotopic distributions. - Abstract: Resolving components and determining their pseudo-molecular ions (PMIs) are crucial steps in identifying complex herbal mixtures by liquid chromatography–mass spectrometry. To tackle such labor-intensive steps, we present here a novel algorithm for simultaneous detection of components and their PMIs. Our method consists of three steps: (1) obtaining a simplified dataset containing only mono-isotopic masses by removal of background noise and isotopic cluster ions based on the isotopic distribution model derived from all the reported natural compounds in dictionary of natural products; (2) stepwise resolving and removing all features of the highest abundant component from current simplified dataset and calculating PMI of each component according to an adduct-ion model, in which all non-fragment ions in a mass spectrum are considered as PMI plus one or several neutral species; (3) visual classification of detected components by principal component analysis (PCA) to exclude possible non-natural compounds (such as pharmaceutical excipients). This algorithm has been successfully applied to a standard mixture and three herbal extract/preparations. It indicated that our algorithm could detect components’ features as a whole and report their PMI with an accuracy of more than 98%. Furthermore, components originated from excipients/contaminants could be easily separated from those natural components in the bi-plots of PCA.

  5. Simultaneous and rapid determination of multiple component concentrations in a Kraft liquor process stream

    Science.gov (United States)

    Li, Jian [Marietta, GA; Chai, Xin Sheng [Atlanta, GA; Zhu, Junyoung [Marietta, GA

    2008-06-24

    The present invention is a rapid method of determining the concentration of the major components in a chemical stream. The present invention is also a simple, low cost, device of determining the in-situ concentration of the major components in a chemical stream. In particular, the present invention provides a useful method for simultaneously determining the concentrations of sodium hydroxide, sodium sulfide and sodium carbonate in aqueous kraft pulping liquors through use of an attenuated total reflectance (ATR) tunnel flow cell or optical probe capable of producing a ultraviolet absorbency spectrum over a wavelength of 190 to 300 nm. In addition, the present invention eliminates the need for manual sampling and dilution previously required to generate analyzable samples. The inventive method can be used in Kraft pulping operations to control white liquor causticizing efficiency, sulfate reduction efficiency in green liquor, oxidation efficiency for oxidized white liquor and the active and effective alkali charge to kraft pulping operations.

  6. Simultaneously estimating the task-related and stimulus-evoked components of hemodynamic imaging measurements.

    Science.gov (United States)

    Herman, Max Charles; Cardoso, Mariana M B; Lima, Bruss; Sirotin, Yevgeniy B; Das, Aniruddha

    2017-07-01

    Task-related hemodynamic responses contribute prominently to functional magnetic resonance imaging (fMRI) recordings. They reflect behaviorally important brain states, such as arousal and attention, and can dominate stimulus-evoked responses, yet they remain poorly understood. To help characterize these responses, we present a method for parametrically estimating both stimulus-evoked and task-related components of hemodynamic responses from subjects engaged in temporally predictable tasks. The stimulus-evoked component is modeled by convolving a hemodynamic response function (HRF) kernel with spiking. The task-related component is modeled by convolving a Fourier-series task-related function (TRF) kernel with task timing. We fit this model with simultaneous electrode recordings and intrinsic-signal optical imaging from the primary visual cortex of alert, task-engaged monkeys. With high [Formula: see text], the model returns HRFs that are consistent across experiments and recording sites for a given animal and TRFs that entrain to task timing independent of stimulation or local spiking. When the task schedule conflicts with that of stimulation, the TRF remains locked to the task emphasizing its behavioral origins. The current approach is strikingly more robust to fluctuations than earlier ones and gives consistently, if modestly, better fits. This approach could help parse the distinct components of fMRI recordings made in the context of a task.

  7. Chaos-Based Simultaneous Compression and Encryption for Hadoop.

    Science.gov (United States)

    Usama, Muhammad; Zakaria, Nordin

    2017-01-01

    Data compression and encryption are key components of commonly deployed platforms such as Hadoop. Numerous data compression and encryption tools are presently available on such platforms and the tools are characteristically applied in sequence, i.e., compression followed by encryption or encryption followed by compression. This paper focuses on the open-source Hadoop framework and proposes a data storage method that efficiently couples data compression with encryption. A simultaneous compression and encryption scheme is introduced that addresses an important implementation issue of source coding based on Tent Map and Piece-wise Linear Chaotic Map (PWLM), which is the infinite precision of real numbers that result from their long products. The approach proposed here solves the implementation issue by removing fractional components that are generated by the long products of real numbers. Moreover, it incorporates a stealth key that performs a cyclic shift in PWLM without compromising compression capabilities. In addition, the proposed approach implements a masking pseudorandom keystream that enhances encryption quality. The proposed algorithm demonstrated a congruent fit within the Hadoop framework, providing robust encryption security and compression.

  8. Analytical Study of Component Based Software Engineering

    OpenAIRE

    Iqbaldeep Kaur; Parvinder S. Sandhu; Hardeep Singh; Vandana Saini

    2009-01-01

    This paper is a survey of current component-based software technologies and the description of promotion and inhibition factors in CBSE. The features that software components inherit are also discussed. Quality Assurance issues in componentbased software are also catered to. The feat research on the quality model of component based system starts with the study of what the components are, CBSE, its development life cycle and the pro & cons of CBSE. Various attributes are s...

  9. Rapidly Simultaneous Determination of Six Effective Components in Cistanche tubulosa by Near Infrared Spectroscopy

    Directory of Open Access Journals (Sweden)

    Xinhong Wang

    2017-05-01

    Full Text Available Quantitative determination of multiple effective components in a given plant usually requires a very large amount of authentic natural products. In this study, we proposed a rapid and non-destructive method for the simultaneous determination of echinacoside, verbascoside, mannitol, sucrose, glucose and fructose in Cistanche tubulosa by near infrared spectroscopy (NIRS. Near infrared diffuse reflectance spectroscopy (DRS and high performance liquid chromatography (HPLC were conducted on 116 batches of C. tubulosa samples. The DRS data were processed using standard normal variety (SNV and multiplicative scatter correction (MSC methods. Partial least squares regression (PLSR was utilized to build calibration models for components-of-interest in C. tubulosa. All models were then assessed by calculating the root mean square error of calibration (RMSEC, correlation coefficient of calibration (r. The r values of all six calibration models were determined to be greater than 0.94, suggesting each model is reliable. Therefore, the quantitative NIR models reported in this study can be qualified to accurately quantify the contents of six medicinal components in C. tubulosa.

  10. Simultaneous Absorptance and Thermal-Diffusivity Determination of Optical Components with Laser Calorimetry Technique

    Science.gov (United States)

    Wang, Yanru; Li, Bincheng

    2012-11-01

    The laser calorimetry (LCA) technique is used to determine simultaneously the absorptances and thermal diffusivities of optical components. An accurate temperature model, in which both the finite thermal conductivity and the finite sample size are taken into account, is employed to fit the experimental temperature data measured with an LCA apparatus for a precise determination of the absorptance and thermal diffusivity via a multiparameter fitting procedure. The uniqueness issue of the multiparameter fitting is discussed in detail. Experimentally, highly reflective (HR) samples prepared with electron-beam evaporation on different substrates (BK7, fused silica, and Ge) are measured with LCA. For the HR-coated sample on a fused silica substrate, the absorptance is determined to be 15.4 ppm, which is close to the value of 17.6 ppm, determined with a simplified temperature model recommended in the international standard ISO11551. The thermal diffusivity is simultaneously determined via multiparameter fitting to be approximately 6.63 × 10-7 m2 · s-1 with a corresponding square variance of 4.8 × 10-4. The fitted thermal diffusivity is in reasonably good agreement with the literature value (7.5 × 10-7 m2 · s -1). Good agreement is also obtained for samples with BK7 and Ge substrates.

  11. Quality evaluation of Huaijiao pill by chromatographic fingerprint and simultaneous determination of its major bioactive components

    Directory of Open Access Journals (Sweden)

    Shuangqin Wang

    2016-08-01

    Full Text Available For quality control purpose, an approach of combining chromatographic fingerprint of Huaijiao pill (HP and simultaneous determination of its major bioactive components was developed using high performance liquid chromatography coupled with diode array detector (HPLC--DAD. For fingerprint analysis, 16 peaks were selected as the characteristic peaks to evaluate the similarities of different samples collected from different batches of three manufacturers. The similarities of 17 Huaijiao pill samples were beyond 0.966, indicating that samples from different batches and manufacturers were, to some extent, consistent. Additionally, simultaneous quantification of seven bioactive markers, namely sophoricoside, baicalin, naringin, genistein, rutin, quercetin and 5-O-methylvisammioside, in HP was performed to interpret the quality consistency. The validation of the proposed approach was acceptable, with the accuracy of 90.2%–106.9% in recovery test. The intra-day and inter-day precisions of the method were evaluated and the RSD values were less than 2.81%. The results from the quantitative data showed that the contents of six marker compounds (except for 5-O-methylvisammioside were quite consistent between batches produced by one manufacturer and significantly distinctive among different manufacturers. The proposed approach was expected to be developed as a powerful tool for the quality control of HP.

  12. [Simultaneous analysis of six effective components in the anti-Alzheimer's disease effective component group of Xiao-Xu-Ming Decoction].

    Science.gov (United States)

    Li, Zhonghong; Ni, Kunyi; Du, Guanhua

    2007-01-01

    A method based on high performance liquid chromatography (HPLC) was developed for the quantitative determination of six components in an anti-Alzheimer medicine, Xiao-Xu-Ming Decoction, which is an effective prescription in treating stroke and the sequela of stroke by herbalist doctors for thousands years. The effective component group (ECG) was made according to the results of high-throughput screening, and the curative effect of ECG was validated on aging rats. In this method an ODS column was used. The mobile phase consisted of water-formic acid-ethylenediamine (A; 100: 0.1: 0.1, v/v) and methanol-formic acid (B; 100 : 0.05, v/v), eluted with gradient (0 - 5 min, 20% B; 5 - 100 min, 20% B - 40% B; 100 - 140 min, 40% B - 70% B). The flow rate was 1 mL/min. The detection wavelength was set at 240 nm. Under the above separation conditions, six components belonged to two different categories, indicans and alkaloids, were determined simultaneously. The relationships between the concentrations and the peak areas of these six components were all linear. The recoveries of the six components were 99.1% for paeoniflorin, 99.6% for prim-O-glucosylcimifugin, 98.4% for baicalin, 99.9% for 4'-O-beta-D-glucosyl-5-O-methylvisamminol, 99.6% for fangchinoline, and 102.0% for tetrandrine. The relative standard deviations (RSD) were 1.3%, 1.4%, 0.4%, 0.8%, 0.2%, and 1.4%, respectively. This method is simple and reproducible and it can be used for the quality control of the effective component group of Xiao-Xu-Ming Decoction.

  13. The artifacts of component-based development

    International Nuclear Information System (INIS)

    Rizwan, M.; Qureshi, J.; Hayat, S.A.

    2007-01-01

    Component based development idea was floated in a conference name Mass Produced Software Components in 1968 (1). Since then engineering and scientific libraries are developed to reuse the previously developed functions. This concept is now widely used in SW development as component based development (CBD). Component-based software engineering (CBSE) is used to develop/ assemble software from existing components (2). Software developed using components is called component where (3). This paper presents different architectures of CBD such as Active X, common object request broker architecture (CORBA), remote method invocation (RMI) and simple object access protocol (SOAP). The overall objective of this paper is to support the practice of CBD by comparing its advantages and disadvantages. This paper also evaluates object oriented process model to adapt it for CBD. (author)

  14. Graphene-based spintronic components

    OpenAIRE

    Zeng, Minggang; Shen, Lei; Su, Haibin; Zhou, Miao; Zhang, Chun; Feng, Yuanping

    2010-01-01

    A major challenge of spintronics is in generating, controlling and detecting spin-polarized current. Manipulation of spin-polarized current, in particular, is difficult. We demonstrate here, based on calculated transport properties of graphene nanoribbons, that nearly +-100% spin-polarized current can be generated in zigzag graphene nanoribbons (ZGNRs) and tuned by a source-drain voltage in the bipolar spin diode, in addition to magnetic configurations of the electrodes. This unusual transpor...

  15. Simultaneous Optimization of Topology and Component Sizes for Double Planetary Gear Hybrid Powertrains

    Directory of Open Access Journals (Sweden)

    Weichao Zhuang

    2016-05-01

    Full Text Available Hybrid powertrain technologies are successful in the passenger car market and have been actively developed in recent years. Optimal topology selection, component sizing, and controls are required for competitive hybrid vehicles, as multiple goals must be considered simultaneously: fuel efficiency, emissions, performance, and cost. Most of the previous studies explored these three design dimensions separately. In this paper, two novel frameworks combining these three design dimensions together are presented and compared. One approach is nested optimization which searches through the whole design space exhaustively. The second approach is called enhanced iterative optimization, which executes the topology optimization and component sizing alternately. A case study shows that the later method can converge to the global optimal design generated from the nested optimization, and is much more computationally efficient. In addition, we also address a known issue of optimal designs: their sensitivity to parameters, such as varying vehicle weight, which is a concern especially for the design of hybrid buses. Therefore, the iterative optimization process is applied to design a robust multi-mode hybrid electric bus under different loading scenarios as the final design challenge of this paper.

  16. A structured overview of simultaneous component based data integration

    NARCIS (Netherlands)

    Van Deun, Katrijn; Smilde, Age K.; van der Werf, Mariet J.; Kiers, Henk A. L.; Van Mechelen, Iven

    2009-01-01

    Background: Data integration is currently one of the main challenges in the biomedical sciences. Often different pieces of information are gathered on the same set of entities (e. g., tissues, culture samples, biomolecules) with the different pieces stemming, for example, from different measurement

  17. A structured overview of simultaneous component based data integration

    NARCIS (Netherlands)

    van Deun, K.; Smilde, A.K.; van der Werf, M.J.; Kiers, H.A.L.; van Mechelen, I.

    2009-01-01

    Background: Data integration is currently one of the main challenges in the biomedical sciences. Often different pieces of information are gathered on the same set of entities (e.g., tissues, culture samples, biomolecules) with the different pieces stemming, for example, from different measurement

  18. Real Time Engineering Analysis Based on a Generative Component Implementation

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Klitgaard, Jens

    2007-01-01

    The present paper outlines the idea of a conceptual design tool with real time engineering analysis which can be used in the early conceptual design phase. The tool is based on a parametric approach using Generative Components with embedded structural analysis. Each of these components uses...... without jumping from aesthetics to structural digital design tools and back, but to work with both simultaneously and real time. The engineering level of knowledge is incorporated at a conceptual thinking level, i.e. qualitative information is used in stead of using quantitative information. An example...... with a static determinate roof structure modelled by beam components is given. The example outlines the idea of the tool for conceptual design in early phase of a multidisciplinary design process between architecture and structural engineering....

  19. Principal component articial neural network calibration models for the simultaneous spectrophotometric estimation of mefenamic acid and paracetamol in tablets

    Directory of Open Access Journals (Sweden)

    RAJAPPAN MANAVALAN

    2006-11-01

    Full Text Available Simultaneous estimation of all drug components in a multicomponent analgesic dosage form with artificial neural networks calibration models using UV spectrophotometry is reported as a simple alternative to using separate models for each component. Anovel approach for calibration using a compund spectral dataset derived from three spectra of each component is described. The spectra of mefenamic acid and paracetamol were recorded as several concentrations within their linear range and used to compute a calibration mixture between the wavelengths 220 to 340 nm. Neural networks trained by a Levenberg–Marquardt algorithm were used for building and optimizing the calibration models using MATALAB® Neural Network Toolbox and were compared with the principal component regression model. The calibration models were throughly evaluated at several concentration levels using 104 spectra obtained for 52 synthetic binary mixtures prepared using orthogonal designs. The optimized model showed sufficient robustness even when the calibration sets were constructed from a different set of pure spectra of the components. The simultaneous prediction of both components by a single neural netwook with the suggested calibration approach was successful. The model could accurately estimate the drugs, with satisfactory precision and accuracy, in tablet dosage with no interference from excipients as indicated by the results of a recovery study.

  20. X-ray communication based simultaneous communication and ranging

    International Nuclear Information System (INIS)

    Song Shi-Bin; Xu Lu-Ping; Zhang Hua; Gao Na

    2015-01-01

    To improve the link efficiency and decrease the payloads in space explorations, a novel simultaneous communication and ranging method based on x-ray communication (XCOM) is proposed in this paper. A delicate signal symbol structure is utilized to achieve simultaneous data transmission and range measurement. With the designed symbol structure, the ranging information is imbedded into the communication signal and transmitted with it simultaneously. The range measurement is realized by the two-way transmission of the range information. To illustrate the proposed method, firstly, the principle of the method is introduced and the signal processing procedure is presented. Then, the performance of the proposed method is analyzed theoretically in various aspects, including the acquisition probability, the bit error rate, the ranging jitter, etc. Besides, numerical experiments are conducted to verify the proposed method and evaluate the system performance. The simulation results show that the proposed method is feasible and that the system performance is influenced by the parameters concerning the signal symbol structure. Compared with the previous methods, the proposed method improves the link efficiency and is beneficial for system miniaturization and integration, which could provide a potential option for future deep space explorations. (paper)

  1. Component-Based Cartoon Face Generation

    Directory of Open Access Journals (Sweden)

    Saman Sepehri Nejad

    2016-11-01

    Full Text Available In this paper, we present a cartoon face generation method that stands on a component-based facial feature extraction approach. Given a frontal face image as an input, our proposed system has the following stages. First, face features are extracted using an extended Active Shape Model. Outlines of the components are locally modified using edge detection, template matching and Hermit interpolation. This modification enhances the diversity of output and accuracy of the component matching required for cartoon generation. Second, to bring cartoon-specific features such as shadows, highlights and, especially, stylish drawing, an array of various face photographs and corresponding hand-drawn cartoon faces are collected. These cartoon templates are automatically decomposed into cartoon components using our proposed method for parameterizing cartoon samples, which is fast and simple. Then, using shape matching methods, the appropriate cartoon component is selected and deformed to fit the input face. Finally, a cartoon face is rendered in a vector format using the rendering rules of the selected template. Experimental results demonstrate effectiveness of our approach in generating life-like cartoon faces.

  2. Selection of components based on their importance

    International Nuclear Information System (INIS)

    Stvan, F.

    2004-12-01

    A proposal is presented for sorting components of the Dukovany nuclear power plant with respect to their importance. The classification scheme includes property priority, property criticality and property structure. Each area has its criteria with weight coefficients to calculate the importance of each component by the Risk Priority Number method. The aim of the process is to generate a list of components in order of operating and safety importance, which will help spend funds to ensure operation and safety in an optimal manner. This proposal is linked to a proposal for a simple database which should serve to enter information and perform assessments. The present stage focused on a safety assessment of components categorized in safety classes BT1, BT2 and BT3 pursuant to Decree No. 76. Assessment was performed based ona PSE study for Level 1. The database includes inputs for entering financial data, which are represented by a potential damage resulting from the given failure and by the loss of MWh in financial terms. In a next input, the failure incidence intensity and time of correction can be entered. Information regarding the property structure, represented by the degree of backup and reparability of the component, is the last input available

  3. Scientific data base for safeguards components

    International Nuclear Information System (INIS)

    Hall, R.C.; Jones, R.D.

    1978-01-01

    The need to store and maintain vast amounts of data and the desire to avoid nonfunctional redundancy have provided an impetus for modern data base technology. Large-scale data base management systems (DBMS) have emerged during the past two decades evolving from earlier generalized file processing systems. This evolution has primarily involved certain business applications (e.g., production control, payroll, order entry) because of their high volume data processing characterization. Current data base technology, however, is becoming increasingly concerned with generality. Many diverse applications, including scientific ones, are benefiting from the generalized data base management software which has resulted. The concept of a data base management system is examined. The three common models which have been proposed for organizing data and relationships are identified: the network model, the hierarchical model, and the relational model. A specific implementation using a hierarchical data base management system is described. This is the data base for safeguards components which has been developed at Sandia Laboratories using the System 2000 developed by MRI Systems Corporation. Its organization, components, and functions are presented. The various interfaces it permits to user programs (e.g., safeguards automated facility evaluation software) and interactive terminal users are described

  4. Four simultaneous component models for the analysis of multivariate time series from more than one subject to model intraindividual and interindividual differences

    NARCIS (Netherlands)

    Timmerman, Mariek E.; Kiers, Henk A.L.

    A class of four simultaneous component models for the exploratory analysis of multivariate time series collected from more than one subject simultaneously is discussed. In each of the models, the multivariate time series of each subject is decomposed into a few series of component scores and a

  5. A desirability functions-based approach for simultaneous ...

    African Journals Online (AJOL)

    In order to improve product quality, all these quantitative and qualitative responses must be optimized simultaneously. ... Few researchers have proposed some alternative approaches for optimizing an ... quantitative and ordinal response variables simultaneously under Taguchi's framework of robust design approach.

  6. A Component-Based Access Control Monitor

    Science.gov (United States)

    Liu, Zhiming; Morisset, Charles; Stolz, Volker

    A control of access to information is increasingly becoming necessary as the systems managing this information is more and more open and available through non secure networks. Integrating an access control monitor within a large system is a complex task, since it has to be an "all or nothing" integration. The least error or mistake could lead to jeopardize the whole system. We present a formal specification of an access control monitor using the calculus of refinement of component and object systems (rCOS). We illustrate this implementation with the well known Role Based Access Control (RBAC) policy and we show how to integrate it within a larger system. Keywords: Component, Access Control, RBAC, Composition

  7. The comparison of partial least squares and principal component regression in simultaneous spectrophotometric determination of ascorbic acid, dopamine and uric acid in real samples

    Directory of Open Access Journals (Sweden)

    Habiboallah Khajehsharifi

    2017-05-01

    Full Text Available Partial least squares (PLS1 and principal component regression (PCR are two multivariate calibration methods that allow simultaneous determination of several analytes in spite of their overlapping spectra. In this research, a spectrophotometric method using PLS1 is proposed for the simultaneous determination of ascorbic acid (AA, dopamine (DA and uric acid (UA. The linear concentration ranges for AA, DA and UA were 1.76–47.55, 0.57–22.76 and 1.68–28.58 (in μg mL−1, respectively. However, PLS1 and PCR were applied to design calibration set based on absorption spectra in the 250–320 nm range for 36 different mixtures of AA, DA and UA, in all cases, the PLS1 calibration method showed more quantitative prediction ability than PCR method. Cross validation method was used to select the optimum number of principal components (NPC. The NPC for AA, DA and UA was found to be 4 by PLS1 and 5, 12, 8 by PCR. Prediction error sum of squares (PRESS of AA, DA and UA were 1.2461, 1.1144, 2.3104 for PLS1 and 11.0563, 1.3819, 4.0956 for PCR, respectively. Satisfactory results were achieved for the simultaneous determination of AA, DA and UA in some real samples such as human urine, serum and pharmaceutical formulations.

  8. A systematic approach for component-based software development

    NARCIS (Netherlands)

    Guareis de farias, Cléver; van Sinderen, Marten J.; Ferreira Pires, Luis

    2000-01-01

    Component-based software development enables the construction of software artefacts by assembling prefabricated, configurable and independently evolving building blocks, called software components. This paper presents an approach for the development of component-based software artefacts. This

  9. A desirability functions-based approach for simultaneous ...

    African Journals Online (AJOL)

    simultaneous optimization of quantitative and ordinal response variables. But none of these approaches results in an efficient optimal solution with respect to the desirability values of all the individual response variables. It motivated us to develop a more useful approach for simultaneously optimizing industrial processes ...

  10. Component failure data base of TRIGA reactors

    International Nuclear Information System (INIS)

    Djuricic, M.

    2004-10-01

    This compilation provides failure data such as first criticality, component type description (reactor component, population, cumulative calendar time, cumulative operating time, demands, failure mode, failures, failure rate, failure probability) and specific information on each type of component of TRIGA Mark-II reactors in Austria, Bangladesh, Germany, Finland, Indonesia, Italy, Indonesia, Slovenia and Romania. (nevyjel)

  11. Simultaneous determination of glycols based on fluorescence anisotropy

    International Nuclear Information System (INIS)

    Garcia Sanchez, F.; Navas Diaz, A.; Lopez Guerrero, M.M.

    2007-01-01

    Simultaneous determination of non-fluorescent glycols in mixtures without separation or chemical transformation steps is described. Two methods based in the measure of fluorescence anisotropy of a probe such as fluorescein dissolved in the analyte or analyte mixtures are described. In the first method, the anisotropy spectra of pure and mixtures of analytes are used to quantitative determination (if the fluorophor concentration is in a range where fluorescence intensity is proportional to concentration). In the second method, a calibration curve anisotropy-concentration based on the application of the Perrin equation is established. The methods presented here are capable of directly resolving binary mixtures of non-fluorescent glycols on the basis of differences on the fluorescence anisotropy of a fluorescence tracer. Best analytical performances were obtained by application of the method based on Perrin equation. This method is simple, rapid and allows the determination of mixtures of glycols with reasonable accuracy and precision. Detection limits are limited by the quantum yield and anisotropy values of the tracer in the solvents. Recovery values are related to the differences in anisotropy values of the tracer in the pure solvents. Mixtures of glycerine/ethylene glycol (GL/EG), ethylene glycol/1,2-propane diol (EG/1,2-PPD) and polyethylene glycol 400/1,2-propane diol (PEG 400/1,2-PPD) were analysed and recovery values are within 95-120% in the Perrin method. Relative standard deviation are in the range 1.3-2.9% and detection limits in the range 3.9-8.9%

  12. Nonlinear Process Fault Diagnosis Based on Serial Principal Component Analysis.

    Science.gov (United States)

    Deng, Xiaogang; Tian, Xuemin; Chen, Sheng; Harris, Chris J

    2018-03-01

    Many industrial processes contain both linear and nonlinear parts, and kernel principal component analysis (KPCA), widely used in nonlinear process monitoring, may not offer the most effective means for dealing with these nonlinear processes. This paper proposes a new hybrid linear-nonlinear statistical modeling approach for nonlinear process monitoring by closely integrating linear principal component analysis (PCA) and nonlinear KPCA using a serial model structure, which we refer to as serial PCA (SPCA). Specifically, PCA is first applied to extract PCs as linear features, and to decompose the data into the PC subspace and residual subspace (RS). Then, KPCA is performed in the RS to extract the nonlinear PCs as nonlinear features. Two monitoring statistics are constructed for fault detection, based on both the linear and nonlinear features extracted by the proposed SPCA. To effectively perform fault identification after a fault is detected, an SPCA similarity factor method is built for fault recognition, which fuses both the linear and nonlinear features. Unlike PCA and KPCA, the proposed method takes into account both linear and nonlinear PCs simultaneously, and therefore, it can better exploit the underlying process's structure to enhance fault diagnosis performance. Two case studies involving a simulated nonlinear process and the benchmark Tennessee Eastman process demonstrate that the proposed SPCA approach is more effective than the existing state-of-the-art approach based on KPCA alone, in terms of nonlinear process fault detection and identification.

  13. SAT-based verification for timed component connectors

    NARCIS (Netherlands)

    S. Kemper (Stephanie)

    2011-01-01

    textabstractComponent-based software construction relies on suitable models underlying components, and in particular the coordinators which orchestrate component behaviour. Verifying correctness and safety of such systems amounts to model checking the underlying system model. The model checking

  14. Lifestyles Based on Health Components in Iran

    Directory of Open Access Journals (Sweden)

    Babaei

    2016-07-01

    Full Text Available Context Lifestyle is a way employed by people, groups and nations and is formed in specific geographical, economic, political, cultural and religious texts. Health depends on lifestyle and is essential to preserve and promote health and improve lifestyle. Objectives The present study aimed to investigate lifestyle based on health-oriented components in Iran. Data Sources The research was conducted through E-banks including scientific information database (SID, Iran medical science databank (Iran Medex, Iran journal databank (Magiran and other databases such as Elsevier, PubMed and google scholar meta search engine regarding the subject from 2000 to 2014. Moreover, Official Iranian statistics and information were applied. The search terms used included lifestyle, health, health promoting behaviors, health-oriented lifestyle and lifestyle in Iran. Study Selection In the primary research, many papers were observed out of which 157 (120 in Farsi and 37 in English were selected. Data Extraction Following the careful study of these papers and excluding the unqualified papers, 19 papers with thorough information and higher relevance with the research purpose were selected. Results After examining articles based on the selected keywords and search strategies, 215 articles (134 in Farsi and 81 in English were obtained. Components of lifestyle and health are increasing in recent years; therefore, 8 (42% and 11 (58% articles were published during 2005 - 2010 and 2011 - 2014, respectively. Among them, there were 3 (16%, 8 (42%, 2 (10.5%, 2 (10.5% and 0 articles on the review of literature, descriptive-analytic, qualitative, analytic and descriptive articles, respectively. Conclusions Due to positive effect of healthy lifestyle on health promotion of individuals, it would be better for the government to provide comprehensive programs and policies in the society to enhance awareness of people about positive effects of health-oriented lifestyle on life and

  15. Simultaneous Principal-Component Extraction with Application to Adaptive Blind Multiuser Detection

    Directory of Open Access Journals (Sweden)

    Erdogmus Deniz

    2002-01-01

    Full Text Available SIPEX-G is a fast-converging, robust, gradient-based PCA algorithm that has been recently proposed by the authors. Its superior performance in synthetic and real data compared with its benchmark counterparts makes it a viable alternative in applications where subspace methods are employed. Blind multiuser detection is one such area, where subspace methods, recently developed by researchers, have proven effective. In this paper, the SIPEX-G algorithm is presented in detail, convergence proofs are derived, and the performance is demonstrated in standard subspace problems. These sub space problems include direction of arrival estimation for incoming signals impinging on a linear array of sensors, nonstationary random process subspace tracking, and adaptive blind multiuser detection.

  16. Synthesis of porphyrin-incorporated polymers and their application for simultaneous detection of multimetal components by using spectrophotometry

    Science.gov (United States)

    Asano, Takaharu; Wang, Pi-Chao; Iwasaki, Akio

    2010-01-01

    For the purpose of detection of multimetal components in environment, alteration of the spectrophotometrical metal sensitivity of porphyrin was attempted. Two porphyrin-incorporated polymers were newly synthesized by the free radical copolymerization of protoporphyrin IX disodium salt and vinyl monomers, and their metal sensitivities were examined by measuring the difference absorption spectra. These porphyrin-incorporated polymers showed different metal sensitivities and their sensitivities were altered by change of pH. Three measuring reagents, which were different in the combination of the porphyrin-incorporated polymers and pH, were used for the simultaneous detection of multimetal components in metal ion mixtures. The difference spectra of these reagents showed the separate peaks corresponding to six metal ions, Bi(III), Co(II), Cu(II), Mn(II), Pb(II), and Zn(II). The spectra were acquired reproducibly by using standard normal variate (SNV) transformation. Furthermore, this method was applied to detect multimetal components in water samples such as tap water and industrial effluent.

  17. Agile Objects: Component-Based Inherent Survivability

    National Research Council Canada - National Science Library

    Chien, Andrew

    2003-01-01

    We have developed a framework called Agile Objects which leverages component object models and enables the construction of survivable systems that support increased application survivability through elusive technologies...

  18. Considerations for RFID-Based Indoor Simultaneous Tracking

    Science.gov (United States)

    Papapostolou, Apostolia; Chaouchi, Hakima

    Context-aware applications is not just a vision. Advances in wireless communications and mobile capabilities have revolutionized the way services are brought to users, i.e. adapted to their context. Location is a key attribute of the term context and thus, an accurate location determination system is of paramount importance. RFID (Radio Frequency IDentification) is an emerging technology and recently has been explored for its applicability in location sensing systems. In this paper, we focus on an RFID-based localization approach in an indoor multi-user environment and model its most adverse implicating factors, that is collisions among its main components and interference from indoor characteristics. Extensive simulations are conducted to characterize and evaluate the performance behavior of the proposed scheme in environments with different levels of severity.

  19. The Component-Based Application for GAMESS

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Fang [Iowa State Univ., Ames, IA (United States)

    2007-01-01

    GAMESS, a quantum chetnistry program for electronic structure calculations, has been freely shared by high-performance application scientists for over twenty years. It provides a rich set of functionalities and can be run on a variety of parallel platforms through a distributed data interface. While a chemistry computation is sophisticated and hard to develop, the resource sharing among different chemistry packages will accelerate the development of new computations and encourage the cooperation of scientists from universities and laboratories. Common Component Architecture (CCA) offers an enviromnent that allows scientific packages to dynamically interact with each other through components, which enable dynamic coupling of GAMESS with other chetnistry packages, such as MPQC and NWChem. Conceptually, a cotnputation can be constructed with "plug-and-play" components from scientific packages and require more than componentizing functions/subroutines of interest, especially for large-scale scientific packages with a long development history. In this research, we present our efforts to construct cotnponents for GAMESS that conform to the CCA specification. The goal is to enable the fine-grained interoperability between three quantum chemistry programs, GAMESS, MPQC and NWChem, via components. We focus on one of the three packages, GAMESS; delineate the structure of GAMESS computations, followed by our approaches to its component development. Then we use GAMESS as the driver to interoperate integral components from the other tw"o packages, arid show the solutions for interoperability problems along with preliminary results. To justify the versatility of the design, the Tuning and Analysis Utility (TAU) components have been coupled with GAMESS and its components, so that the performance of GAMESS and its components may be analyzed for a wide range of systetn parameters.

  20. The development of component-based information systems

    CERN Document Server

    Cesare, Sergio de; Macredie, Robert

    2015-01-01

    This work provides a comprehensive overview of research and practical issues relating to component-based development information systems (CBIS). Spanning the organizational, developmental, and technical aspects of the subject, the original research included here provides fresh insights into successful CBIS technology and application. Part I covers component-based development methodologies and system architectures. Part II analyzes different aspects of managing component-based development. Part III investigates component-based development versus commercial off-the-shelf products (COTS), includi

  1. Simultaneous Determination of Essential Oil Components and Fatty Acids in Fennel using Gas Chromatography with a Polar Capillary Column.

    Science.gov (United States)

    Najdoska-Bogdanov, Menče; Bogdanov, Jane B; Stefova, Marina

    2015-09-01

    Cultivated and wild growing samples of fennel (Foeniculum vulgare Mill., Apiaceae) from R. Macedonia were studied for their volatiles and fatty acid composition. The main essential oil components isolated via hydrodistillation were: trans-anethole (>80%), estragole (method for characterization of both the non-polar volatile and non volatile fractions was developed using n-hexane and dichloromethane (3:1, v/v) in a Soxhlet extraction followed by transesterification. The obtained extracts were then characterized and the dominant fatty acid was 18:1 (petroselinic and oleic acid) 75.0-82.8%, followed by 18:2 (linoleic acid) 10.8-16.2% and other fatty acids: palmitic (4.3-6.9%), stearic (1.2-1.7%) and myristic (0-2.9%). The results for the volatile fraction after Soxhlet extraction and transesterification did not significantly differ from results obtained after hydrodistillation, especially for the main components (trans-anethole, estragole, fenchone and limonene), implying that the developed method can be used for simultaneous determination of volatiles and fatty acids.

  2. Simultaneous determination of four active components in Alisma orientale (Sam. Juz. by HPLC–DAD using a single reference standard

    Directory of Open Access Journals (Sweden)

    Yao-Wen Zhang

    2015-04-01

    Full Text Available A rapid, simple and practical high-performance liquid chromatography method coupled with diode array detector (HPLC–DAD was developed to evaluate the quality of Alisma orientale (Sam. Juz. through a simultaneous determination of four major active triterpenes using a single standard to determine the multi-components (SSDMCs. Alisol B 23-acetate was selected as the reference compound for calculating the relative response factors. All calibration curves showed good linearity (R2>0.9998 within test ranges. RSDs for intra- and inter-day of four analytes were less than 3.6% and 2.3%; the overall recovery was 92.1–110.2% (SSDMC. The proposed method was successfully applied to quantify the four components in 20 samples from different localities in China. Moreover, significant variations were demonstrated in the content of these compounds. In addition, hierarchical clustering analysis (HCA and principal components analysis (PCA were performed to differentiate and classify the samples based on the contents of Alisol C 23-acetate, Alisol A, Alisol A 24-acetate and Alisol B 23-acetate. This simple, rapid, low-cost and reliable HPLC–DAD method using SSDMC is suitable for routine quantitative analysis and quality control of A. orientale (Sam. Juz. Keywords: SSDMC, Alisma orientale (Sam. Juz, Quality control, HCA, PCA

  3. Optimization of medium components and physicochemical parameters to simultaneously enhance microbial growth and production of lypolitic enzymes by Stenotrophomonas sp.

    Science.gov (United States)

    Mazzucotelli, Cintia Anabela; Agüero, María Victoria; Del Rosario Moreira, María; Ansorena, María Roberta

    2016-05-01

    The optimization of lipase and esterase production (LP and EP) and bacterial growth (BG) of a Stenotrophomonas sp. strain was developed. For this purpose, the effect of five different medium components and three physicochemical parameters were evaluated using a Plackett-Burman statistical design. Among eight variables, stirring speed, pH, and peptone concentration were found to be the most effective factors on the three responses under evaluation. An optimization study applying Box-Behnken response surface methodology was used to study the interactive effects of the three selected variables on LP/EP and microorganism growth. Predicted models were found to be significant with high regression coefficients (90%-99%). By using the desirability function approach, the optimum condition applying simultaneous optimization of the three responses under study resulted to be: stirring speed of 100 rpm, pH of 7.5, and a peptone concentration of 10 g/L, with a desirability value of 0.977. Under these optimal conditions, it is possible to achieve in the optimized medium a 15-fold increase in esterase productivity, a 117-fold increase in lipase production, and a 9-log CFU/mL increase in BG, compared with the basal medium without agitation. © 2015 International Union of Biochemistry and Molecular Biology, Inc.

  4. [Simultaneous determination of five effective components in Sijunzi bolus using high performance liquid chromatography-evaporation light scattering detection].

    Science.gov (United States)

    Li, Chunying; Zhang, Xiaojun

    2010-01-01

    A high performance liquid chromatographic (HPLC) method was developed for the simultaneous determination of lobetyolin, pachymic acid, glycyrrhizic acid, atractylenoide III and atractylenolide I in Sijunzi bolus. The separation was performed on an HIQ SIL C18 V column (250 mm x 4.6 mm, 5 microm) with 0.5% acetic acid-methanol as the mobile phase of gradient elution at a flow rate of 1.0 mL/min. The detection was performed with an evaporation light scattering detector (ELSD) and the sample volume was 10 microL. The temperature of drift tube and heating grade of nebulizer was respectively set at 55 degrees C and 60% at 0.2 MPa of pressure. Nitrogen gas was used as carrier gas. Under the optimized conditions, there were good linear relationships between the logarithm values of mass concentration and the peak areas of lobetyolin, pachymic acid, glycyrrhizic acid, atractylenoide III and atractylenolide I in the ranges of 0.076 - 1.21, 0.048 -0.76, 0.153 - 2.45, 0.045 - 0.72 and 0.098 - 1.56 g/L, respectively. The recoveries of the five components were between 97.13% and 100.25%, the relative standard deviations (RSDs) were between 1.23% and 2.44%. This method is simple, rapid, accurate and suitable for the quality control of Sijunzi bolus.

  5. Optimization of Component Based Software Engineering Model Using Neural Network

    OpenAIRE

    Gaurav Kumar; Pradeep Kumar Bhatia

    2014-01-01

    The goal of Component Based Software Engineering (CBSE) is to deliver high quality, more reliable and more maintainable software systems in a shorter time and within limited budget by reusing and combining existing quality components. A high quality system can be achieved by using quality components, framework and integration process that plays a significant role. So, techniques and methods used for quality assurance and assessment of a component based system is different from those of the tr...

  6. Aptamer- and nucleic acid enzyme-based systems for simultaneous detection of multiple analytes

    Science.gov (United States)

    Lu, Yi [Champaign, IL; Liu, Juewen [Albuquerque, NM

    2011-11-15

    The present invention provides aptamer- and nucleic acid enzyme-based systems for simultaneously determining the presence and optionally the concentration of multiple analytes in a sample. Methods of utilizing the system and kits that include the sensor components are also provided. The system includes a first reactive polynucleotide that reacts to a first analyte; a second reactive polynucleotide that reacts to a second analyte; a third polynucleotide; a fourth polynucleotide; a first particle, coupled to the third polynucleotide; a second particle, coupled to the fourth polynucleotide; and at least one quencher, for quenching emissions of the first and second quantum dots, coupled to the first and second reactive polynucleotides. The first particle includes a quantum dot having a first emission wavelength. The second particle includes a second quantum dot having a second emission wavelength different from the first emission wavelength. The third polynucleotide and the fourth polynucleotide are different.

  7. Runtime Verification of Component-Based Embedded Software

    NARCIS (Netherlands)

    Sözer, Hasan; Hofmann, C.; Tekinerdogan, B.; Aksit, Mehmet; Gelenbe, Erol; Lent, Ricardo; Sakellari, Georgia

    To deal with increasing size and complexity, component-based software development has been employed in embedded systems. Due to several faults, components can make wrong assumptions about the working mode of the system and the working modes of the other components. To detect mode inconsistencies at

  8. Practical approaches to principal component analysis for simultaneously dealing with missing and censored elements in chemical data.

    Science.gov (United States)

    Stanimirova, I

    2013-09-24

    Multivariate chemical data often contain elements that are missing completely at random and the so-called left-censored elements whose values are only known to be below a definite threshold value (reporting limit). In the last several years, attention has been paid to developing methods for dealing with data containing missing elements and those that can handle data with missing elements and outliers. However, processing data with both missing and left-censored elements is still an ongoing problem. The aim of this work was to investigate which method is most suitable for handling left-censored and missing completely at random elements that are present simultaneously in chemical data by using a comparison of the generalized nonlinear iterative partial least squares (NIPALS(1)) algorithm that has been recently proposed, methods that include uncertainty information like maximum likelihood principal component analysis, MLPCA(2), and replacement methods. The results of the Monte Carlo simulation study for artificial and real data sets showed that substitution with half of the reporting limit can be used when the percentage of left-censored elements per variable is up to 30-40%. The generalized NIPALS algorithm is generally recommended for a large percentage of left-censored elements per variable and particularly when a large number of variables are censored. The expectation-maximization approach applied to data with censored elements substituted with half of the reporting limits can be a strategy for dealing with missing and left-censored elements in data, but if the converge criterion is not fulfilled, then the generalized NIPALS algorithm can be applied. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Component-based event composition modeling for CPS

    Science.gov (United States)

    Yin, Zhonghai; Chu, Yanan

    2017-06-01

    In order to combine event-drive model with component-based architecture design, this paper proposes a component-based event composition model to realize CPS’s event processing. Firstly, the formal representations of component and attribute-oriented event are defined. Every component is consisted of subcomponents and the corresponding event sets. The attribute “type” is added to attribute-oriented event definition so as to describe the responsiveness to the component. Secondly, component-based event composition model is constructed. Concept lattice-based event algebra system is built to describe the relations between events, and the rules for drawing Hasse diagram are discussed. Thirdly, as there are redundancies among composite events, two simplification methods are proposed. Finally, the communication-based train control system is simulated to verify the event composition model. Results show that the event composition model we have constructed can be applied to express composite events correctly and effectively.

  10. Base isolation strategies for structures and components

    International Nuclear Information System (INIS)

    Varma, Veto; Reddy, G.R.; Vaze, K.K.; Kushwaha, H.S.

    2003-08-01

    In the present report the effect of laminated rubber bearing (LRB) system on the dynamic response of the structure was studied. A LRB system was designed and tested in the laboratory for its dynamic characteristics. Finite element analysis was also performed and based on this analysis, isolator for PHWR nuclear power plant was designed. Analysis of the building was performed with and without isolator. Comparison of responses was made in terms of frequencies, accelerations and displacements and floor response spectra. (author)

  11. Simultaneous extraction and concentration of water pollution tracers using ionic-liquid-based systems.

    Science.gov (United States)

    Dinis, Teresa B V; Passos, Helena; Lima, Diana L D; Sousa, Ana C A; Coutinho, João A P; Esteves, Valdemar I; Freire, Mara G

    2017-07-29

    Human activities are responsible for the release of innumerous substances into the aquatic environment. Some of these substances can be used as pollution tracers to identify contamination sources and to prioritize monitoring and remediation actions. Thus, their identification and quantification are of high priority. However, due to their presence in complex matrices and at significantly low concentrations, a pre-treatment/concentration step is always required. As an alternative to the currently used pre-treatment methods, mainly based on solid-phase extractions, aqueous biphasic systems (ABS) composed of ionic liquids (ILs) and K 3 C 6 H 5 O 7 are here proposed for the simultaneous extraction and concentration of mixtures of two important pollution tracers, caffeine (CAF) and carbamazepine (CBZ). An initial screening of the IL chemical structure was carried out, with extraction efficiencies of both tracers to the IL-rich phase ranging between 95 and 100%, obtained in a single-step. These systems were then optimized in order to simultaneously concentrate CAF and CBZ from water samples followed by HPLC-UV analysis, for which no interferences of the ABS phase-forming components and other interferents present in a wastewater effluent sample have been found. Based on the saturation solubility data of both pollution tracers in the IL-rich phase, the maximum estimated concentration factors of CAF and CBZ are 28595- and 8259-fold. IL-based ABS can be thus envisioned as effective pre-treatment techniques of environmentally-related aqueous samples for a more accurate monitoring of mixtures of pollution tracers. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Component-Based Approach in Learning Management System Development

    Science.gov (United States)

    Zaitseva, Larisa; Bule, Jekaterina; Makarov, Sergey

    2013-01-01

    The paper describes component-based approach (CBA) for learning management system development. Learning object as components of e-learning courses and their metadata is considered. The architecture of learning management system based on CBA being developed in Riga Technical University, namely its architecture, elements and possibilities are…

  13. Cryotrons based on a simultaneously distributed Josephson contact

    Energy Technology Data Exchange (ETDEWEB)

    Bakhtin, P.A.; Lapir, G.M.; Makhov, V.I.; Samus, A.N.; Semenov, V.K.; Tyablikov, A.V.

    1982-01-01

    The features of the construction of cryotrons based on an evenly distributed Josephson contact are examined. The possibility is demonstrated of producing cryotrons with an assigned form of the controlling characteristic through the spatial isolation of the transport and controlling streams. The theoretical and experimental controlling characteristics of cryotrons based on bridges of variable thickness with connectors of normal metal are cited. The proposed principles of cryotron production are also suitable for other types of Josephson contacts.

  14. A sensitive HPLC-MS method for simultaneous determination of thirteen components in rat plasma and its application to pharmacokinetic study of Tanreqing injection.

    Science.gov (United States)

    Feng, Su-Xiang; Li, Xian-He; Wang, Meng-Meng; Hao, Rui; Li, Meng-Meng; Zhang, Lei; Wang, Zhe

    2018-01-30

    A rapid, sensitive and selective method based on high-performance liquid chromatography coupled with Q-Exactive mass spectrometry was developed and validated for simultaneous quantification of thirteen components in rat plasma, including chlorogenic acid, 5-caffeoylquinic acid, 4-caffeoylquinic acid, luteoloside, isochlorogenic acid A, B and C, scutellarin, baicalin, wogonin, baicalein, phillyrin and forsythoside A. After precipitating proteins from the plasma samples with methanol, chromatographic separation of the thirteen components was achieved by using an XBridge™ C 18 column (2.1mm×150mm, 5μm) with the mobile phase consisting of methanol and 0.1% formic acid in water at a flow rate of 0.3mL/min. High-resolution MS quantification was adopted with detection on a Q-Exactive mass spectrometer in full-scan mode, and the results were obtained using a mass extraction window of 10ppm at a mass resolution of 70, 000. All the calibration curves exhibited good linearity (r 2 >0.991) over the measured ranges. The lower limit of quantitation (LLOQ) was in the range of 1.05-8.13ng/mL. The intra- and inter-day precision (RSD) was less than 11.70% and the accuracy (RE) ranged from -5.58% to 12.29%. No significant matrix effect was observed and the extraction recoveries of all the analytes were more than 79.36%. The developed method was applied to a pharmacokinetic study of the thirteen ingredients in rats after intravenous administration of Tanreqing at three doses of 3, 6 and 12mL/kg. The results indicated that 8 of the 13 components, isochlorogenic acid A, B and C, chlorogenic acid, baicalin, wogonin, luteoloside and forsythoside A, had linear pharmacokinetic properties in the tested dosage range. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Projection computation based on pixel in simultaneous algebraic reconstruction technique

    International Nuclear Information System (INIS)

    Wang Xu; Chen Zhiqiang; Xiong Hua; Zhang Li

    2005-01-01

    SART is an important arithmetic of image reconstruction, in which the projection computation takes over half of the reconstruction time. An efficient way to compute projection coefficient matrix together with memory optimization is presented in this paper. Different from normal method, projection lines are located based on every pixel, and the following projection coefficient computation can make use of the results. Correlation of projection lines and pixels can be used to optimize the computation. (authors)

  16. An architectural pattern for designing component-based application frameworks

    NARCIS (Netherlands)

    Parsons, David; Rashid, Awais; Telea, Alexandru; Speck, Andreas

    2006-01-01

    A widely used architecture for the development of software systems is the component-based application framework. Such frameworks offer two mechanisms. First, they provide component integration and interoperability services which make it possible to extend the framework with various third-party

  17. Simultaneous Class-based and Live Video Streamed Teaching

    DEFF Research Database (Denmark)

    Ørngreen, Rikke; Levinsen, Karin Ellen Tweddell; Jelsbak, Vibe Alopaeus

    2015-01-01

    The Bachelor Programme in Biomedical Laboratory Analysis at VIA's healthcare university college in Aarhus has established a blended class which combines traditional and live broadcast teaching (via an innovative choice of video conferencing system). On the so-called net-days, students have...... the choice of either attending teaching sessions in the traditional way or working from home via the Internet. The education was motivated to expand the use of technologysupported teaching, by offering a flexible study programme, thereby increasing the recruitment base. The analysis described in this article...... project is presented. The objective of the project was to identify potentials and barriers from an ICT-supported learning perspective; to develop robust educational designs and teaching scenarios, and to qualify teaching staff in teaching activities which involve the use of the blended class model, thus...

  18. A modified principal component analysis-based utility theory ...

    African Journals Online (AJOL)

    user

    modified PCA-based utility theory (UT) approach for optimization of correlated responses. ... Keywords: EDM; Correlated responses; Optimization; Principal component analysis; Proportion of quality loss reduction; ...... On stochastic optimization: Taguchi MethodsTM demystified; its limitations and fallacy clarified.

  19. Flexible optical network components based on densely integrated microring resonators

    NARCIS (Netherlands)

    Geuzebroek, D.H.

    2005-01-01

    This thesis addresses the design, realization and characterization of reconfigurable optical network components based on multiple microring resonators. Since thermally tunable microring resonators can be used as wavelength selective space switches, very compact devices with high complexity and

  20. A modified principal component analysis-based utility theory ...

    African Journals Online (AJOL)

    traditional machining processes having multiple performance characteristics, some of which are usually correlated. So, ideally, use of principal component analysis (PCA)-based approaches that take into account the possible correlations ...

  1. HLA component based environment for distributed multiscale simulations

    NARCIS (Netherlands)

    Rycerz, K.; Bubak, M.; Sloot, P.M.A.; Getov, V.

    2008-01-01

    In this paper we present the Grid environment that supports application building basing on a High Level Architecture (HLA) component model. The proposed model is particularly suitable for distributed multiscale simulations. Original HLA partly supports interoperability and composability of

  2. Parallel PDE-Based Simulations Using the Common Component Architecture

    International Nuclear Information System (INIS)

    McInnes, Lois C.; Allan, Benjamin A.; Armstrong, Robert; Benson, Steven J.; Bernholdt, David E.; Dahlgren, Tamara L.; Diachin, Lori; Krishnan, Manoj Kumar; Kohl, James A.; Larson, J. Walter; Lefantzi, Sophia; Nieplocha, Jarek; Norris, Boyana; Parker, Steven G.; Ray, Jaideep; Zhou, Shujia

    2006-01-01

    The complexity of parallel PDE-based simulations continues to increase as multimodel, multiphysics, and multi-institutional projects become widespread. A goal of component based software engineering in such large-scale simulations is to help manage this complexity by enabling better interoperability among various codes that have been independently developed by different groups. The Common Component Architecture (CCA) Forum is defining a component architecture specification to address the challenges of high-performance scientific computing. In addition, several execution frameworks, supporting infrastructure, and general purpose components are being developed. Furthermore, this group is collaborating with others in the high-performance computing community to design suites of domain-specific component interface specifications and underlying implementations. This chapter discusses recent work on leveraging these CCA efforts in parallel PDE-based simulations involving accelerator design, climate modeling, combustion, and accidental fires and explosions. We explain how component technology helps to address the different challenges posed by each of these applications, and we highlight how component interfaces built on existing parallel toolkits facilitate the reuse of software for parallel mesh manipulation, discretization, linear algebra, integration, optimization, and parallel data redistribution. We also present performance data to demonstrate the suitability of this approach, and we discuss strategies for applying component technologies to both new and existing applications

  3. Economical multiparty simultaneous quantum identity authentication based on Greenberger–Horne–Zeilinger states

    International Nuclear Information System (INIS)

    Yu-Guang, Yang; Qiao-Yan, Wen

    2009-01-01

    A multiparty simultaneous quantum identity authentication protocol based on Greenberger–Horne–Zeilinger (GHZ) states is proposed. The multi-user can be authenticated by a trusted third party (TTP) simultaneously. Compared with the scheme proposed recently (Wang et al 2006 Chin. Phys. Lett. 23(9) 2360), the proposed scheme has the advantages of consuming fewer quantum and classical resources and lessening the difficulty and intensity of necessary operations. (general)

  4. Computer-Based Study Guides II: Educational Components and Advantages.

    Science.gov (United States)

    Harden, R. M.; Smyth, J. J.

    1994-01-01

    Examines the potential contributions of computers to medical education and, in particular, the use of computer-based study guides. Presents the educational functions of various study guide components and lists advantages and disadvantages of computer-based study guides over print-based guides. (LZ)

  5. Simultaneous wavelength and orbital angular momentum demultiplexing using tunable MEMS-based Fabry-Perot filter

    DEFF Research Database (Denmark)

    Lyubopytov, Vladimir; Porfirev, Alexey P.; Gurbatov, Stanislav O.

    2017-01-01

    In this paper, we experimentally demonstrate simultaneous wavelength and orbital angular momentum (OAM) multiplexing/demultiplexing of 10 Gbit/s data streams using a new on-chip micro-component-tunable MEMS-based Fabry-Perot filter integrated with a spiral phase plate. In the experiment, two......B at the harddecision forward-error correction (HD-FEC) bit-error-rate (BER) limit 3.8 × 10□3 when multiplexing a Gaussian beam and OAM beams of azimuthal orders 1, 2 and 3 respectively. In case of phase modulation, power penalties do not exceed 1.77, 0.54 and 0.79 dB respectively. At the 0.4 nm wavelength grid......, maximum power penalties at the HD-FEC BER threshold relative to the 0.8 nm wavelength spacing read 0.83, 0.84 and 1.15 dB when multiplexing a Gaussian beam and OAM beams of 1st, 2nd and 3rd orders respectively. The novelty and impact of the proposed filter design is in providing practical, integrable...

  6. Component-based Systems Reconfigurations Using Graph Grammars

    Directory of Open Access Journals (Sweden)

    O. Kouchnarenko

    2016-01-01

    Full Text Available Dynamic reconfigurations can modify the architecture of component-based systems without incurring any system downtime. In this context, the main contribution of the present article is the establishment of correctness results proving component-based systems reconfigurations using graph grammars. New guarded reconfigurations allow us to build reconfigurations based on primitive reconfiguration operations using sequences of reconfigurations and the alternative and the repetitive constructs, while preserving configuration consistency. A practical contribution consists of the implementation of a component-based model using the GROOVE graph transformation tool. Then, after enriching the model with interpreted configurations and reconfigurations in a consistency compatible manner, a simulation relation is exploited to validate component systems’ implementations. This sound implementation is illustrated on a cloud-based multitier application hosting environment managed as a component-based system.

  7. Reliability-Based Design of Wind Turbine Components

    DEFF Research Database (Denmark)

    Toft, Henrik Stensgaard; Sørensen, John Dalsgaard

    2010-01-01

    influence the reliability is presented. For wind turbines tests with the basic materials or structural components are often performed during the design process. By adopting a reliability based design approach information from these tests can be taken into account in the design process. However, in normal...... demonstrated how partial safety factors can be derived for reliability-based design and how the partial safety factors changes dependent on the uncertainty in the test results.......Application of reliability-based design for wind turbines requires a definition of the probabilistic basis for the individual components of the wind turbine. In the present paper reliability-based design of structural wind turbine components is considered. A framework for the uncertainties which...

  8. A Simultaneous Analytical Method to Profile Non-Volatile Components with Low Polarity Elucidating Differences Between Tobacco Leaves Using Atmospheric Pressure Chemical Ionization Mass Spectrometry Detection

    Directory of Open Access Journals (Sweden)

    Ishida Naoyuki

    2016-04-01

    Full Text Available A comprehensive analytical method using liquid chromatography atmospheric pressure chemical ionization mass spectrometry detector (LC/APCI-MSD was developed to determine key non-volatile components with low polarity elucidating holistic difference among tobacco leaves. Nonaqueous reversed-phase chromatography (NARPC using organic solvent ensured simultaneous separation of various components with low polarity in tobacco resin. Application of full-scan mode to APCI-MSD hyphenated with NARPC enabled simultaneous detection of numerous intense product ions given by APCI interface. Parameters for data processing to filter, feature and align peaks were adjusted in order to strike a balance between comprehensiveness and reproducibility in analysis. 63 types of components such as solanesols, chlorophylls, phytosterols, triacylglycerols, solanachromene and others were determined on total ion chromatograms according to authentic components, wavelength spectrum and mass spectrum. The whole area of identified entities among the ones detected on total ion chromatogram reached to over 60% and major entities among those identified showed favorable linearity of determination coefficient of over 0.99. The developed method and data processing procedure were therefore considered feasible for subsequent multivariate analysis. Data matrix consisting of a number of entities was then subjected to principal component analysis (PCA and hierarchical clustering analysis. Cultivars of tobacco leaves were distributed far from each cultivar on PCA score plot and each cluster seemed to be characterized by identified non-volatile components with low polarity. While fluecured Virginia (FCV was loaded by solanachromene, phytosterol esters and triacylglycerols, free phytosterols and chlorophylls loaded Burley (BLY and Oriental (ORI respectively. Consequently the whole methodology consisting of comprehensive method and data processing procedure proved useful to determine key-components

  9. Secure wireless embedded systems via component-based design

    DEFF Research Database (Denmark)

    Hjorth, T.; Torbensen, R.

    2010-01-01

    communication component for distributed wireless embedded devices. The components communicate using the Secure Embedded Exchange Protocol (SEEP), which has been designed for flexible trust establishment so that small, resource-constrained, wireless embedded systems are able to communicate short command messages......This paper introduces the method secure-by-design as a way of constructing wireless embedded systems using component-based modeling frameworks. This facilitates design of secure applications through verified, reusable software. Following this method we propose a security framework with a secure...

  10. Isocyanide based multi component reactions in combinatorial chemistry.

    NARCIS (Netherlands)

    Dömling, A.

    1998-01-01

    Although usually regarded as a recent development, the combinatorial approach to the synthesis of libraries of new drug candidates was first described as early as 1961 using the isocyanide-based one-pot multicomponent Ugi reaction. Isocyanide-based multi component reactions (MCR's) markedly differ

  11. A channel-based coordination model for component composition

    NARCIS (Netherlands)

    F. Arbab (Farhad)

    2002-01-01

    textabstractIn this paper, we present $P epsilon omega$, a paradigm for composition of software components based on the notion of mobile channels. $P repsilon omega$ is a channel-based exogenous coordination model wherein complex coordinators, called {em connectors are compositionally built out of

  12. Feature selection for neural network based defect classification of ceramic components using high frequency ultrasound.

    Science.gov (United States)

    Kesharaju, Manasa; Nagarajah, Romesh

    2015-09-01

    The motivation for this research stems from a need for providing a non-destructive testing method capable of detecting and locating any defects and microstructural variations within armour ceramic components before issuing them to the soldiers who rely on them for their survival. The development of an automated ultrasonic inspection based classification system would make possible the checking of each ceramic component and immediately alert the operator about the presence of defects. Generally, in many classification problems a choice of features or dimensionality reduction is significant and simultaneously very difficult, as a substantial computational effort is required to evaluate possible feature subsets. In this research, a combination of artificial neural networks and genetic algorithms are used to optimize the feature subset used in classification of various defects in reaction-sintered silicon carbide ceramic components. Initially wavelet based feature extraction is implemented from the region of interest. An Artificial Neural Network classifier is employed to evaluate the performance of these features. Genetic Algorithm based feature selection is performed. Principal Component Analysis is a popular technique used for feature selection and is compared with the genetic algorithm based technique in terms of classification accuracy and selection of optimal number of features. The experimental results confirm that features identified by Principal Component Analysis lead to improved performance in terms of classification percentage with 96% than Genetic algorithm with 94%. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Statistical optimization of medium components and physicochemical parameters to simultaneously enhance bacterial growth and esterase production by Bacillus thuringiensis.

    Science.gov (United States)

    Mazzucotelli, Cintia Anabela; Moreira, María del Rosario; Ansorena, María Roberta

    2016-01-01

    Bacillus thuringiensis is a genus extensively studied because of its high potential for biotechnological application, principally in biocontrol techniques. However, the optimization of esterase production by this strain has been scarcely studied. The aim of this work was to select and optimize the physicochemical and nutritional parameters that significantly influence the growth and esterase production of B. thuringiensis. To this purpose, 6 nutritional factors and 2 physicochemical parameters were evaluated using a Plackett-Burman design. Significant variables were optimized using a Box-Behnken design and through the desirability function to select the levels of the variables that simultaneously maximize microbial growth and esterase production. The optimum conditions resulting from simultaneous optimization of the responses under study were found to be 1 g/L glucose, 15 g/L peptone, and 3.25 g/L NaCl. Under these optimal conditions, it was possible to achieve a 2.5 log CFU/mL increase in bacterial growth and a 113-fold increase in esterase productivity, compared with minimal medium without agitation.

  14. Nuclear component design ontology building based on ASME codes

    International Nuclear Information System (INIS)

    Bao Shiyi; Zhou Yu; He Shuyan

    2005-01-01

    The adoption of ontology analysis in the study of concept knowledge acquisition and representation for the nuclear component design process based on computer-supported cooperative work (CSCW) makes it possible to share and reuse numerous concept knowledge of multi-disciplinary domains. A practical ontology building method is accordingly proposed based on Protege knowledge model in combination with both top-down and bottom-up approaches together with Formal Concept Analysis (FCA). FCA exhibits its advantages in the way it helps establish and improve taxonomic hierarchy of concepts and resolve concept conflict occurred in modeling multi-disciplinary domains. With Protege-3.0 as the ontology building tool, a nuclear component design ontology based ASME codes is developed by utilizing the ontology building method. The ontology serves as the basis to realize concept knowledge sharing and reusing of nuclear component design. (authors)

  15. A METHOD OF LEUKOCYTE SEGMENTATION BASED ON S COMPONENT AND B COMPONENT IMAGES

    Directory of Open Access Journals (Sweden)

    YIPING YANG

    2014-01-01

    Full Text Available A leukocyte segmentation method based on S component and B component images is proposed. Threshold segmentation operation is applied to get two binary images in S component and B component images. The samples used in this study are peripheral blood smears. It is easy to find from the two binary images that gray values are the same at every corresponding pixels in the leukocyte cytoplasm region, but opposite in the other regions. The feature shows that "IMAGE AND" operation can be employed on the two binary images to segment the cytoplasm region of leukocyte. By doing "IMAGE XOR" operation between cytoplasm region and nucleus region, the leukocyte segmentation can be retrieved effectively. The segmentation accuracy is evaluated by comparing the segmentation result of the proposed method with the manual segmentation by a hematologist. Experiment results show that the proposed method is of a higher segmentation accuracy and it also performs well when leukocytes overlap with erythrocytes. The average segmentation accuracy of the proposed method reaches 97.7% for segmenting five types of leukocyte. Good segmentation results provide an important foundation for leukocytes automatic recognition.

  16. Towards a Component Based Model for Database Systems

    Directory of Open Access Journals (Sweden)

    Octavian Paul ROTARU

    2004-02-01

    Full Text Available Due to their effectiveness in the design and development of software applications and due to their recognized advantages in terms of reusability, Component-Based Software Engineering (CBSE concepts have been arousing a great deal of interest in recent years. This paper presents and extends a component-based approach to object-oriented database systems (OODB introduced by us in [1] and [2]. Components are proposed as a new abstraction level for database system, logical partitions of the schema. In this context, the scope is introduced as an escalated property for transactions. Components are studied from the integrity, consistency, and concurrency control perspective. The main benefits of our proposed component model for OODB are the reusability of the database design, including the access statistics required for a proper query optimization, and a smooth information exchange. The integration of crosscutting concerns into the component database model using aspect-oriented techniques is also discussed. One of the main goals is to define a method for the assessment of component composition capabilities. These capabilities are restricted by the component’s interface and measured in terms of adaptability, degree of compose-ability and acceptability level. The above-mentioned metrics are extended from database components to generic software components. This paper extends and consolidates into one common view the ideas previously presented by us in [1, 2, 3].[1] Octavian Paul Rotaru, Marian Dobre, Component Aspects in Object Oriented Databases, Proceedings of the International Conference on Software Engineering Research and Practice (SERP’04, Volume II, ISBN 1-932415-29-7, pages 719-725, Las Vegas, NV, USA, June 2004.[2] Octavian Paul Rotaru, Marian Dobre, Mircea Petrescu, Integrity and Consistency Aspects in Component-Oriented Databases, Proceedings of the International Symposium on Innovation in Information and Communication Technology (ISIICT

  17. Robust face detection based on components and their topology

    Science.gov (United States)

    Goldmann, Lutz; Mönich, Ullrich; Sikora, Thomas

    2006-01-01

    This paper presents a novel approach for automatic and robust object detection. It utilizes a component-based approach that combines techniques from both statistical and structural pattern recognition domain. While the component detection relies on Haar-like features and an AdaBoost trained classifier cascade, the topology verification is based on graph matching techniques. The system was applied to face detection and the experiments show its outstanding performance in comparison to other face detection approaches. Especially in the presence of partial occlusions, uneven illumination and out-of-plane rotations it yields higher robustness.

  18. Ontology-Based Quality Attributes Prediction in Component-Based Development

    OpenAIRE

    Chengpu Li; Rob Pooley; Xiaodong Liu

    2010-01-01

    Despite the success that Component-Based Development (CBD) has achieved so far, componentmismatch remains as a big obstacle for wider and smoother component reuse. Mismatch refers that theselected component does not satisfy the functional requirements, or that it fails the user’s expectation interms of the Quality Attributes (QAs) of the component-based system. This allows us the potential topredict the quality attributes of a software system by analysing the result of component retrieval. In...

  19. Principal component analysis-adaptive neuro-fuzzy inference systems (ANFISs) for the simultaneous spectrophotometric determination of three metals in water samples.

    Science.gov (United States)

    Goodarzi, Mohammad; Olivieri, Alejandro C; Freitas, Matheus P

    2009-08-15

    A spectrophotometric method for the simultaneous determination of Al(III), Co(II) and Ni(II) using Alizarin Red S as a chelating agent was developed. The parameters controlling the behavior of the system were investigated and optimum conditions were selected. The presence of non-linearities was checked using Mallows augmented partial residual plots. To take into account these non-linearities, a principal component analysis-adaptive neuro-fuzzy inference systems (PC-ANFISs) method was used for the analysis of ternary mixtures of Al(III), Co(II) and Ni(II) over the range of 0.05-0.90, 0.05-4.05 and 0.05-0.95 microg mL(-1), respectively. Absorbance data were collected between 370 and 700 nm. The method was applied to accurately and simultaneously determines the content of metal ions in several synthetic mixtures.

  20. Component based modelling of piezoelectric ultrasonic actuators for machining applications

    Science.gov (United States)

    Saleem, A.; Salah, M.; Ahmed, N.; Silberschmidt, V. V.

    2013-07-01

    Ultrasonically Assisted Machining (UAM) is an emerging technology that has been utilized to improve the surface finishing in machining processes such as turning, milling, and drilling. In this context, piezoelectric ultrasonic transducers are being used to vibrate the cutting tip while machining at predetermined amplitude and frequency. However, modelling and simulation of these transducers is a tedious and difficult task. This is due to the inherent nonlinearities associated with smart materials. Therefore, this paper presents a component-based model of ultrasonic transducers that mimics the nonlinear behaviour of such a system. The system is decomposed into components, a mathematical model of each component is created, and the whole system model is accomplished by aggregating the basic components' model. System parameters are identified using Finite Element technique which then has been used to simulate the system in Matlab/SIMULINK. Various operation conditions are tested and performed to demonstrate the system performance.

  1. Component based modelling of piezoelectric ultrasonic actuators for machining applications

    International Nuclear Information System (INIS)

    Saleem, A; Ahmed, N; Salah, M; Silberschmidt, V V

    2013-01-01

    Ultrasonically Assisted Machining (UAM) is an emerging technology that has been utilized to improve the surface finishing in machining processes such as turning, milling, and drilling. In this context, piezoelectric ultrasonic transducers are being used to vibrate the cutting tip while machining at predetermined amplitude and frequency. However, modelling and simulation of these transducers is a tedious and difficult task. This is due to the inherent nonlinearities associated with smart materials. Therefore, this paper presents a component-based model of ultrasonic transducers that mimics the nonlinear behaviour of such a system. The system is decomposed into components, a mathematical model of each component is created, and the whole system model is accomplished by aggregating the basic components' model. System parameters are identified using Finite Element technique which then has been used to simulate the system in Matlab/SIMULINK. Various operation conditions are tested and performed to demonstrate the system performance

  2. Context sensitivity and ambiguity in component-based systems design

    Energy Technology Data Exchange (ETDEWEB)

    Bespalko, S.J.; Sindt, A.

    1997-10-01

    Designers of components-based, real-time systems need to guarantee to correctness of soft-ware and its output. Complexity of a system, and thus the propensity for error, is best characterized by the number of states a component can encounter. In many cases, large numbers of states arise where the processing is highly dependent on context. In these cases, states are often missed, leading to errors. The following are proposals for compactly specifying system states which allow the factoring of complex components into a control module and a semantic processing module. Further, the need for methods that allow for the explicit representation of ambiguity and uncertainty in the design of components is discussed. Presented herein are examples of real-world problems which are highly context-sensitive or are inherently ambiguous.

  3. Model-based crosstalk compensation for simultaneous 99mTc/123I dual-isotope brain SPECT imaging.

    Science.gov (United States)

    Du, Yong; Tsui, Benjamin M W; Frey, Eric C

    2007-09-01

    In this work, we developed a model-based method to estimate and compensate for the crosstalk contamination in simultaneous 123I and 99mTc dual isotope brain single photo emission computed tomography imaging. The model-based crosstalk compensation (MBCC) includes detailed modeling of photon interactions inside both the object and the detector system. In the method, scatter in the object is modeled using the effective source scatter estimation technique, including contributions from all the photon emissions. The effects of the collimator-detector response, including the penetration and scatter components due to high-energy 123I photons, are modeled using precalculated tables of Monte Carlo simulated point-source response functions obtained from sources in air at various distances from the face of the collimator. The model-based crosstalk estimation method was combined with iterative reconstruction based compensation to reduce contamination due to crosstalk. The MBCC method was evaluated using Monte Carlo simulated and physical phantom experimentally acquired simultaneous dual-isotope data. Results showed that, for both experimental and simulation studies, the model-based method provided crosstalk estimates that were in good agreement with the true crosstalk. Compensation using MBCC improved image contrast and removed the artifacts for both Monte Carlo simulated and experimentally acquired data. The results were in good agreement with images acquired without any crosstalk contamination.

  4. Model-based crosstalk compensation for simultaneous Tc99m∕I123 dual-isotope brain SPECT imaging.

    Science.gov (United States)

    Du, Yong; Tsui, Benjamin M W; Frey, Eric C

    2007-09-01

    In this work, we developed a model-based method to estimate and compensate for the crosstalk contamination in simultaneous I123 and Tc99m dual isotope brain single photo emission computed tomography imaging. The model-based crosstalk compensation (MBCC) includes detailed modeling of photon interactions inside both the object and the detector system. In the method, scatter in the object is modeled using the effective source scatter estimation technique, including contributions from all the photon emissions. The effects of the collimator-detector response, including the penetration and scatter components due to high-energy I123 photons, are modeled using pre-calculated tables of Monte Carlo simulated point-source response functions obtained from sources in air at various distances from the face of the collimator. The model-based crosstalk estimation method was combined with iterative reconstruction based compensation to reduce contamination due to crosstalk. The MBCC method was evaluated using Monte Carlo simulated and physical phantom experimentally acquired simultaneous dual-isotope data. Results showed that, for both experimental and simulation studies, the model-based method provided crosstalk estimates that were in good agreement with the true crosstalk. Compensation using MBCC improved image contrast and removed the artifacts for both Monte Carlo simulated and experimentally acquired data. The results were in good agreement with images acquired without any crosstalk contamination. © 2007 American Association of Physicists in Medicine.

  5. Simultaneous all-channel OTDM demultiplexing based on complete optical Fourier transformation

    DEFF Research Database (Denmark)

    Guan, Pengyu; Lillieholm, Mads; Røge, Kasper Meldgaard

    2016-01-01

    We demonstrate simultaneous OTDM demultiplexing of all 16-channels for 160-Gbit/s DPSK and 320-Gbit/s DQPSK signals based on complete OFT. Furthermore, numerical simulations show promising results for extending the proposed technique to spectrally efficient Nyquist-OTDM....

  6. Simultaneously Optimizing Storage Location Assignment at Forward Area and Reserve Area - a Decomposition Based Heuristic

    DEFF Research Database (Denmark)

    Bloch, Søren; Christiansen, Christian Holk

    versa. This, however, is often neglected in the existing literature. We solve the TSLAP simultaneously for the reserve area and the forward area. Based on randomly generated test instances we show that the solutions of TSLAP compare favorably to solutions found by other algorithms proposed...

  7. Magnetic Resonance-based Motion Correction for Quantitative PET in Simultaneous PET-MR Imaging.

    Science.gov (United States)

    Rakvongthai, Yothin; El Fakhri, Georges

    2017-07-01

    Motion degrades image quality and quantitation of PET images, and is an obstacle to quantitative PET imaging. Simultaneous PET-MR offers a tool that can be used for correcting the motion in PET images by using anatomic information from MR imaging acquired concurrently. Motion correction can be performed by transforming a set of reconstructed PET images into the same frame or by incorporating the transformation into the system model and reconstructing the motion-corrected image. Several phantom and patient studies have validated that MR-based motion correction strategies have great promise for quantitative PET imaging in simultaneous PET-MR. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Monitoring extensions for component-based distributed software

    NARCIS (Netherlands)

    Diakov, N.K.; Papir, Z.; van Sinderen, Marten J.; Quartel, Dick

    2000-01-01

    This paper defines a generic class of monitoring extensions to component-based distributed enterprise software. Introducing a monitoring extension to a legacy application system can be very costly. In this paper, we identify the minimum support for application monitoring within the generic

  9. Management of Globally Distributed Component-Based Software Development Projects

    NARCIS (Netherlands)

    J. Kotlarsky (Julia)

    2005-01-01

    textabstractGlobally Distributed Component-Based Development (GD CBD) is expected to become a promising area, as increasing numbers of companies are setting up software development in a globally distributed environment and at the same time are adopting CBD methodologies. Being an emerging area, the

  10. Continuous release and upgrade of component-based software

    NARCIS (Netherlands)

    T. van der Storm (Tijs)

    2005-01-01

    htmlabstractWe show how under certain assumptions, the release and delivery of software updates can be automated in the context of component-based systems. These updates allow features or fixes to be delivered to users more quickly. Furthermore, user feedback is more accurate, thus enabling quicker

  11. Simultaneous presence of dynamic and sphere action component in the fluorescence quenching of human serum albumin by diphthaloylmaslinic acid

    Energy Technology Data Exchange (ETDEWEB)

    Molina-Bolívar, J.A., E-mail: jmb@uma.es [Departamento de Física Aplicada II, Escuela de Ingenierías, Universidad de Málaga, Campus de Teatinos, 29071, Málaga (Spain); Ruiz, C. Carnero [Departamento de Física Aplicada II, Escuela de Ingenierías, Universidad de Málaga, Campus de Teatinos, 29071, Málaga (Spain); Galisteo-González, F. [Departamento de Física Aplicada, Facultad de Ciencias, Universidad de Granada, Fuentenueva s/n, 18071 Granada (Spain); Medina-O' Donnell, M.; Parra, A. [Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Granada, Fuentenueva s/n, 18071 Granada (Spain)

    2016-10-15

    The fluorescence quenching of human serum albumin (HSA) by diphthaloylmaslinic acid (FMA) at different pH and temperature values was investigated by both steady-state and time-resolved fluorescence. The quenching was found to be appreciable, and an upward-curving Stern–Volmer trend was detected in all cases studied at high drug concentrations. This non-linear dependence reveals the presence of a not purely dynamic fluorescence-quenching mechanism. The experimental data were analyzed using the ground-state complex and sphere action quenching models. The latter model offers a good fit with the experimental results. Time-resolved studies corroborate the simultaneous presence of dynamic and sphere action quenching. The pH significantly affects the binging affinity of FMA to HSA, being stronger at pH 7.4 than at pH 3.0. Thermodynamic parameters ΔG°, ΔH°, and ΔS° were evaluated at different temperatures to examine the nature of the binding forces between FMA and HSA. At pH 7.4, electrostatic interactions controlled the association process, whereas at pH 3.0 the dominant forces seemed to be the hydrophobic interactions. The probable binding site of FMA on HSA was located at subdomain IIA, as suggested by displacement measurements. The surface electrical charge of FMA–HSA complexes was studied by measuring their electrophoretic mobility. Results corroborated the binding of the ligand to the protein. Circular dichroism experiments showed that the FMA binding does not alter the secondary structure of the protein. - Highlights: • The interaction between diphthaloylmaslinic acid and human serum albumin was studied at different temperature and pH values. • Fluorescence studies suggested the simultaneous quenching by dynamic and static mechanisms. • Electrostatic interactions dominate the association process at physiological pH. • Hydrophobic forces control the binding at pH 3.0. • Circular dichroism studies revealed that the secondary structure of HSA was

  12. Simultaneous determination of nineteen major components in Qi She Pill by ultra-high-performance liquid chromatography?tandem mass spectrometry

    OpenAIRE

    Zhang, Zhongliang; Li, Qiang; Li, Qiufen; Du, Simiao; Zhou, Yongquan; Lv, Chunming; Zhao, Yan; Wang, Yongjun; Zhang, Ning

    2014-01-01

    Qi She Pill (QSP) is a traditional Chinese medicine (TCM) prescription that has been used in treating cervical spondylosis radiculopathy for many years. In this study, a simple and sensitive method using ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) on a reverse-phase C18 column was developed for the simultaneous determination of the 19 major components in QSP. We found that the optimum mobile phase for gradient elution was 0.1% formic acid and methanol. ...

  13. Feature-based component model for design of embedded systems

    Science.gov (United States)

    Zha, Xuan Fang; Sriram, Ram D.

    2004-11-01

    An embedded system is a hybrid of hardware and software, which combines software's flexibility and hardware real-time performance. Embedded systems can be considered as assemblies of hardware and software components. An Open Embedded System Model (OESM) is currently being developed at NIST to provide a standard representation and exchange protocol for embedded systems and system-level design, simulation, and testing information. This paper proposes an approach to representing an embedded system feature-based model in OESM, i.e., Open Embedded System Feature Model (OESFM), addressing models of embedded system artifacts, embedded system components, embedded system features, and embedded system configuration/assembly. The approach provides an object-oriented UML (Unified Modeling Language) representation for the embedded system feature model and defines an extension to the NIST Core Product Model. The model provides a feature-based component framework allowing the designer to develop a virtual embedded system prototype through assembling virtual components. The framework not only provides a formal precise model of the embedded system prototype but also offers the possibility of designing variation of prototypes whose members are derived by changing certain virtual components with different features. A case study example is discussed to illustrate the embedded system model.

  14. New Stereo Vision Digital Camera System for Simultaneous Measurement of Cloud Base Height and Atmospheric Visibility

    Science.gov (United States)

    Janeiro, F. M.; Carretas, F.; Palma, N.; Ramos, P. M.; Wagner, F.

    2013-12-01

    Clouds play an important role in many aspects of everyday life. They affect both the local weather as well as the global climate and are an important parameter on climate change studies. Cloud parameters are also important for weather prediction models which make use of actual measurements. It is thus important to have low-cost instrumentation that can be deployed in the field to measure those parameters. This kind of instruments should also be automated and robust since they may be deployed in remote places and be subject to adverse weather conditions. Although clouds are very important in environmental systems, they are also an essential component of airplane safety when visual flight rules (VFR) are enforced, such as in most small aerodromes where it is not economically viable to install instruments for assisted flying. Under VFR there are strict limits on the height of the cloud base, cloud cover and atmospheric visibility that ensure the safety of the pilots and planes. Although there are instruments, available in the market, to measure those parameters, their relatively high cost makes them unavailable in many local aerodromes. In this work we present a new prototype which has been recently developed and deployed in a local aerodrome as proof of concept. It is composed by two digital cameras that capture photographs of the sky and allow the measurement of the cloud height from the parallax effect. The new developments consist on having a new geometry which allows the simultaneous measurement of cloud base height, wind speed at cloud base height and atmospheric visibility, which was not previously possible with only two cameras. The new orientation of the cameras comes at the cost of a more complex geometry to measure the cloud base height. The atmospheric visibility is calculated from the Lambert-Beer law after the measurement of the contrast between a set of dark objects and the background sky. The prototype includes the latest hardware developments that

  15. Integration of Simulink Models with Component-based Software Models

    Directory of Open Access Journals (Sweden)

    MARIAN, N.

    2008-06-01

    Full Text Available Model based development aims to facilitate the development of embedded control systems by emphasizing the separation of the design level from the implementation level. Model based design involves the use of multiple models that represent different views of a system, having different semantics of abstract system descriptions. Usually, in mechatronics systems, design proceeds by iterating model construction, model analysis, and model transformation. Constructing a MATLAB/Simulink model, a plant and controller behavior is simulated using graphical blocks to represent mathematical and logical constructs and process flow, then software code is generated. A Simulink model is a representation of the design or implementation of a physical system that satisfies a set of requirements. A software component-based system aims to organize system architecture and behavior as a means of computation, communication and constraints, using computational blocks and aggregates for both discrete and continuous behavior, different interconnection and execution disciplines for event-based and time-based controllers, and so on, to encompass the demands to more functionality, at even lower prices, and with opposite constraints. COMDES (Component-based Design of Software for Distributed Embedded Systems is such a component-based system framework developed by the software engineering group of Mads Clausen Institute for Product Innovation (MCI, University of Southern Denmark. Once specified, the software model has to be analyzed. One way of doing that is to integrate in wrapper files the model back into Simulink S-functions, and use its extensive simulation features, thus allowing an early exploration of the possible design choices over multiple disciplines. The paper describes a safe translation of a restricted set of MATLAB/Simulink blocks to COMDES software components, both for continuous and discrete behavior, and the transformation of the software system into the S

  16. IAEA's experience in compiling a 'generic component reliability data base'

    International Nuclear Information System (INIS)

    Tomic, B.; Lederman, L.

    1989-01-01

    This paper reflects insights gained compiling data from generic data sources and highlights advantages and pitfalls of using generic component reliability data in PSAs. Considering current IAEA efforts to prepare a computer code package for event tree and fault tree analysis in personal computers (PSAPACK) and the associated need for a reliability data base, a compilation of published component reliability data was undertaken at the IAEA. Some of the features of the data base, like the coding system, are, therefore directly governed by the package. As of today the generic data base contains about 1,000 different records, including practically all the components which are accounted for in PSA studies of Nuclear Power Plants. With many different sources providing different types of information, it was necessary to define a unique record form which would enable inclusion of information in a systematic and consistent manner and also user friendly for information overview and retrieval. The IAEA Generic Data Base was created using the IBM-PC software dBase III, so it can be stored in data base or in the plain text format. Therefore its use is not limited to PASPACK. During the development of the IAEA Generic Data Base insights were gained in how different data bases address different problem areas, namely: component boundary definition, failure mode definition, operating mode definition, operating environment definition. These insights and possible ways of avoiding or solving such problems are addressed in the paper. The IAEA effort to compile a generic component reliability data base aimed at identifying strengths and limitations of generic data usage and at highlighting pitfalls which deserve special consideration. It was also intended to complement the PSAPACK package and to facilitate its use. Moreover, it should be noted, that the IAEA has recently initiated a Coordinated Research Program in Reliability Data Collection, Retrieval and Analysis. In this framework it

  17. Secure wireless embedded systems via component-based design

    DEFF Research Database (Denmark)

    Hjorth, T.; Torbensen, R.

    2010-01-01

    This paper introduces the method secure-by-design as a way of constructing wireless embedded systems using component-based modeling frameworks. This facilitates design of secure applications through verified, reusable software. Following this method we propose a security framework with a secure...... communication component for distributed wireless embedded devices. The components communicate using the Secure Embedded Exchange Protocol (SEEP), which has been designed for flexible trust establishment so that small, resource-constrained, wireless embedded systems are able to communicate short command messages......, with full support for confidentiality, authentication, and integrity using keypairs. The approach has been demonstrated in a multi-platform home automation prototype that can remotely unlock a door using a PDA over the Internet....

  18. A probabilistic model for component-based shape synthesis

    KAUST Repository

    Kalogerakis, Evangelos

    2012-07-01

    We present an approach to synthesizing shapes from complex domains, by identifying new plausible combinations of components from existing shapes. Our primary contribution is a new generative model of component-based shape structure. The model represents probabilistic relationships between properties of shape components, and relates them to learned underlying causes of structural variability within the domain. These causes are treated as latent variables, leading to a compact representation that can be effectively learned without supervision from a set of compatibly segmented shapes. We evaluate the model on a number of shape datasets with complex structural variability and demonstrate its application to amplification of shape databases and to interactive shape synthesis. © 2012 ACM 0730-0301/2012/08-ART55.

  19. Real Time Engineering Analysis Based on a Generative component Implementation

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Klitgaard, Jens

    2007-01-01

    The present paper outlines the idea of a conceptual design tool with real time engineering analysis which can be used in the early conceptual design phase. The tool is based on a parametric approach using Generative Components with embedded structural analysis. Each of these components uses...... the geometry, material properties and fixed point characteristics to calculate the dimensions and subsequent feasibility of any architectural design. The proposed conceptual design tool provides the possibility for the architect to work with both the aesthetic as well as the structural aspects of architecture...... with a static determinate roof structure modelled by beam components is given. The example outlines the idea of the tool for conceptual design in early phase of a multidisciplinary design process between architecture and structural engineering....

  20. Principal Component Analysis-Ranking as a Variable Selection Method for the Simultaneous Spectrophotometric Determination of Phenol, Resorcinol and Catechol in Real Samples

    OpenAIRE

    Nahid Ghasemi; Mohammad Goodarzi; Morteza Khosravi

    2009-01-01

    Simultaneous determination of multicomponents of phenol, resorcinol and catechol with a chemometric technique a PCranking artificial neural network (PCranking-ANN) algorithm is reported in this study. Based on the data correlation coefficient method, 3 representative PCs are selected from the scores of original UV spectral data (35 PCs) as the original input patterns for ANN to build a neural network model. The results obtained by iterating 8000 .The RMSEP for phenol, resorcinol and catechol ...

  1. Research on Air Quality Evaluation based on Principal Component Analysis

    Science.gov (United States)

    Wang, Xing; Wang, Zilin; Guo, Min; Chen, Wei; Zhang, Huan

    2018-01-01

    Economic growth has led to environmental capacity decline and the deterioration of air quality. Air quality evaluation as a fundamental of environmental monitoring and air pollution control has become increasingly important. Based on the principal component analysis (PCA), this paper evaluates the air quality of a large city in Beijing-Tianjin-Hebei Area in recent 10 years and identifies influencing factors, in order to provide reference to air quality management and air pollution control.

  2. Spectral decomposition of asteroid Itokawa based on principal component analysis

    Science.gov (United States)

    Koga, Sumire C.; Sugita, Seiji; Kamata, Shunichi; Ishiguro, Masateru; Hiroi, Takahiro; Tatsumi, Eri; Sasaki, Sho

    2018-01-01

    The heliocentric stratification of asteroid spectral types may hold important information on the early evolution of the Solar System. Asteroid spectral taxonomy is based largely on principal component analysis. However, how the surface properties of asteroids, such as the composition and age, are projected in the principal-component (PC) space is not understood well. We decompose multi-band disk-resolved visible spectra of the Itokawa surface with principal component analysis (PCA) in comparison with main-belt asteroids. The obtained distribution of Itokawa spectra projected in the PC space of main-belt asteroids follows a linear trend linking the Q-type and S-type regions and is consistent with the results of space-weathering experiments on ordinary chondrites and olivine, suggesting that this trend may be a space-weathering-induced spectral evolution track for S-type asteroids. Comparison with space-weathering experiments also yield a short average surface age (component of Itokawa surface spectra is consistent with spectral change due to space weathering and that the spatial variation in the degree of space weathering is very large (a factor of three in surface age), which would strongly suggest the presence of strong regional/local resurfacing process(es) on this small asteroid.

  3. Simultaneous and integrated neutron-based techniques for material analysis of a metallic ancient flute

    Science.gov (United States)

    Festa, G.; Pietropaolo, A.; Grazzi, F.; Sutton, L. F.; Scherillo, A.; Bognetti, L.; Bini, A.; Barzagli, E.; Schooneveld, E.; Andreani, C.

    2013-09-01

    A metallic 19th century flute was studied by means of integrated and simultaneous neutron-based techniques: neutron diffraction, neutron radiative capture analysis and neutron radiography. This experiment follows benchmark measurements devoted to assessing the effectiveness of a multitask beamline concept for neutron-based investigation on materials. The aim of this study is to show the potential application of the approach using multiple and integrated neutron-based techniques for musical instruments. Such samples, in the broad scenario of cultural heritage, represent an exciting research field. They may represent an interesting link between different disciplines such as nuclear physics, metallurgy and acoustics.

  4. Simultaneous and integrated neutron-based techniques for material analysis of a metallic ancient flute

    International Nuclear Information System (INIS)

    Festa, G; Andreani, C; Pietropaolo, A; Grazzi, F; Scherillo, A; Barzagli, E; Sutton, L F; Bognetti, L; Bini, A; Schooneveld, E

    2013-01-01

    A metallic 19th century flute was studied by means of integrated and simultaneous neutron-based techniques: neutron diffraction, neutron radiative capture analysis and neutron radiography. This experiment follows benchmark measurements devoted to assessing the effectiveness of a multitask beamline concept for neutron-based investigation on materials. The aim of this study is to show the potential application of the approach using multiple and integrated neutron-based techniques for musical instruments. Such samples, in the broad scenario of cultural heritage, represent an exciting research field. They may represent an interesting link between different disciplines such as nuclear physics, metallurgy and acoustics. (paper)

  5. Cognitive components underpinning the development of model-based learning.

    Science.gov (United States)

    Potter, Tracey C S; Bryce, Nessa V; Hartley, Catherine A

    2017-06-01

    Reinforcement learning theory distinguishes "model-free" learning, which fosters reflexive repetition of previously rewarded actions, from "model-based" learning, which recruits a mental model of the environment to flexibly select goal-directed actions. Whereas model-free learning is evident across development, recruitment of model-based learning appears to increase with age. However, the cognitive processes underlying the development of model-based learning remain poorly characterized. Here, we examined whether age-related differences in cognitive processes underlying the construction and flexible recruitment of mental models predict developmental increases in model-based choice. In a cohort of participants aged 9-25, we examined whether the abilities to infer sequential regularities in the environment ("statistical learning"), maintain information in an active state ("working memory") and integrate distant concepts to solve problems ("fluid reasoning") predicted age-related improvements in model-based choice. We found that age-related improvements in statistical learning performance did not mediate the relationship between age and model-based choice. Ceiling performance on our working memory assay prevented examination of its contribution to model-based learning. However, age-related improvements in fluid reasoning statistically mediated the developmental increase in the recruitment of a model-based strategy. These findings suggest that gradual development of fluid reasoning may be a critical component process underlying the emergence of model-based learning. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  6. A Component Based Approach to Scientific Workflow Management

    CERN Document Server

    Le Goff, Jean-Marie; Baker, Nigel; Brooks, Peter; McClatchey, Richard

    2001-01-01

    CRISTAL is a distributed scientific workflow system used in the manufacturing and production phases of HEP experiment construction at CERN. The CRISTAL project has studied the use of a description driven approach, using meta- modelling techniques, to manage the evolving needs of a large physics community. Interest from such diverse communities as bio-informatics and manufacturing has motivated the CRISTAL team to re-engineer the system to customize functionality according to end user requirements but maximize software reuse in the process. The next generation CRISTAL vision is to build a generic component architecture from which a complete software product line can be generated according to the particular needs of the target enterprise. This paper discusses the issues of adopting a component product line based approach and our experiences of software reuse.

  7. A component based approach to scientific workflow management

    Science.gov (United States)

    Baker, N.; Brooks, P.; Kovacs, Z.; LeGoff, J.-M.; McClatchey, R.

    2001-08-01

    CRISTAL is a distributed scientific workflow system used in the manufacturing and production phases of HEP experiment construction at CERN. The CRISTAL project has studied the use of a description driven approach, using meta-modelling techniques, to manage the evolving needs of a large physics community. Interest from such diverse communities as bio-informatics and manufacturing has motivated the CRISTAL team to re-engineer the system to customize functionality according to end user requirements but maximize software reuse in the process. The next generation CRISTAL vision is to build a generic component architecture from which a complete software product line can be generated according to the particular needs of the target enterprise. This paper discusses the issues of adopting a component product line based approach and our experiences of software reuse.

  8. A component based approach to scientific workflow management

    International Nuclear Information System (INIS)

    Baker, N.; Brooks, P.; McClatchey, R.; Kovacs, Z.; LeGoff, J.-M.

    2001-01-01

    CRISTAL is a distributed scientific workflow system used in the manufacturing and production phases of HEP experiment construction at CERN. The CRISTAL project has studied the use of a description driven approach, using meta-modelling techniques, to manage the evolving needs of a large physics community. Interest from such diverse communities as bio-informatics and manufacturing has motivated the CRISTAL team to re-engineer the system to customize functionality according to end user requirements but maximize software reuse in the process. The next generation CRISTAL vision is to build a generic component architecture from which a complete software product line can be generated according to the particular needs of the target enterprise. This paper discusses the issues of adopting a component product line based approach and our experiences of software reuse

  9. Simultaneous determination of nineteen major components in Qi She Pill by ultra-high-performance liquid chromatography–tandem mass spectrometry

    Directory of Open Access Journals (Sweden)

    Zhongliang Zhang

    2014-10-01

    Full Text Available Qi She Pill (QSP is a traditional Chinese medicine (TCM prescription that has been used in treating cervical spondylosis radiculopathy for many years. In this study, a simple and sensitive method using ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS on a reverse-phase C18 column was developed for the simultaneous determination of the 19 major components in QSP. We found that the optimum mobile phase for gradient elution was 0.1% formic acid and methanol. The correlation coefficients of all calibration curves were greater than 0.99. Recoveries measured at three concentration levels varied from 95.43% to 102.35%. Relative standard deviations of intra- and inter-day precisions were less than 4.45%. After successfully validating our method, we then applied it to the quantification of 19 components in QSP products to show that this method provides a new standard in quality assessment of TCM prescriptions containing multiple bioactive components.

  10. An optimized ultrasound-assisted extraction and simultaneous quantification of 26 characteristic components with four structure types in functional foods from ginkgo seeds.

    Science.gov (United States)

    Zhou, Guisheng; Yao, Xin; Tang, Yuping; Qian, Dawei; Su, Shulan; Zhang, Li; Jin, Chun; Qin, Yong; Duan, Jin-ao

    2014-09-01

    An optimized method of ultrasound-assisted extraction followed by ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UAE-UHPLC-TQ/MS(2)) was proposed for the simultaneous extraction and determination of 26 characteristic components covering four structure types (flavonoids, terpene lactones, ginkgolic acids and phenylpropanols) in ginkgo seeds (GSs). The UAE parameters (ultrasound power, time and solvent-to-material ratio) were optimized using a response surface methodology. This is the first report of the simultaneous analysis of 26 compounds in Ginkgo biloba using UHPLC-TQ/MS(2); this analysis afforded good linearity, precision, repeatability and accuracy. UAE-UHPLC-TQ/MS(2) was successfully applied to ginkgo seed samples, and the analysis showed that GSs are rich in terpene lactones and could be selected as a healthy food resource. The results suggest that UAE-UHPLC-TQ/MS(2) might be able to be utilized as a tool for the quality assessment of samples from GSs or other related products using flavonoids, terpene lactones, ginkgolic acids and phenylpropanols as markers. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. Up-taper-based Mach-Zehnder interferometer for temperature and strain simultaneous measurement.

    Science.gov (United States)

    Kang, Zexin; Wen, Xiaodong; Li, Chao; Sun, Jiang; Wang, Jing; Jian, Shuisheng

    2014-04-20

    A novel all-fiber sensing configuration for simultaneous measurements of temperature and strain based on the up-taper Mach-Zehnder interferometer (MZI) with an in-line embedded fiber Bragg grating (FBG) is proposed and experimentally demonstrated. This configuration consists of two up-tapers fabricated by an excessive fusion splicing method and a short segment of inscribed FBG. Due to the different responses of the up-taper MZI and the FBG to the uniform variation of temperature and strain, the simultaneous measurement for these two variables could be achieved by real-time monitoring the transmission spectrum. For 0.01 nm wavelength resolution, a resolution of 0.311°C in temperature can be achieved, and the average strain resolution is 10.07 με.

  12. Integration of Simulink Models with Component-based Software Models

    DEFF Research Database (Denmark)

    Marian, Nicolae; Top, Søren

    2008-01-01

    to be analyzed. One way of doing that is to integrate in wrapper files the model back into Simulink S-functions, and use its extensive simulation features, thus allowing an early exploration of the possible design choices over multiple disciplines. The paper describes a safe translation of a restricted set......Model based development aims to facilitate the development of embedded control systems by emphasizing the separation of the design level from the implementation level. Model based design involves the use of multiple models that represent different views of a system, having different semantics...... constructs and process flow, then software code is generated. A Simulink model is a representation of the design or implementation of a physical system that satisfies a set of requirements. A software component-based system aims to organize system architecture and behaviour as a means of computation...

  13. Cryptoschemes Based on Difficulty of Simultaneous Solving Two Different Difficult Problems

    Directory of Open Access Journals (Sweden)

    A.N. Berezin

    2013-10-01

    Full Text Available The paper proposes a general method for construction cryptoschemes based on difficulty of simultaneous solving factoring (FP and discrete logarithm modulo prime problem (DLpP. The proposed approach is applicable for construction digital signatures (usual, blind, collective, public key encryption algorithms, public key distribution protocols, and cryptoschemes of other types. Moreover, the proposed approach provides reducing the signature size and increasing the rate of the cryptoschemes, while comparing with the known designs of the digital signature protocols based on the FP and DLpP.

  14. Bayou Choctaw Well Integrity Grading Component Based on Geomechanical Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Park, Byoung [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Geotechnology & Engineering Dept.

    2016-09-08

    This letter report provides a Bayou Choctaw (BC) Strategic Petroleum Reserve (SPR) well grading system based on the geomechanical simulation. The analyses described in this letter were used to evaluate the caverns’ geomechanical effect on wellbore integrity, which is an important component in the well integrity grading system recently developed by Roberts et al. [2015]. Using these analyses, the wellbores for caverns BC-17 and 20 are expected to be significantly impacted by cavern geomechanics, BC-18 and 19 are expected to be medium impacted; and the other caverns are expected to be less impacted.

  15. Metallic component with a chromium carbide base protective coating

    International Nuclear Information System (INIS)

    Wolfla, T.A.; Tucker, R.C. Jr.

    1976-01-01

    The invention concerns a coating system to protect metal components in sodium and helium cooled nuclear reactors. It includes a nickel or iron based alloy metal substrate, a first coat formed on the substrate and comprising chromium carbides and a binder selected among the chromium-nickel, chromium-cobalt, chromium-iron alloys and the super-alloys, the first coating being between 25 and 380 microns thick, and a surface coating comprising pure chromium carbides and being between 12.5 and 125 microns thick [fr

  16. Simultaneous and quasi-independent strain and temperature sensor based on microstructured optical fiber

    Science.gov (United States)

    Lopez-Aldaba, A.; Auguste, J.-L.; Jamier, R.; Roy, P.; Lopez-Amo, M.

    2017-04-01

    In this paper, a new sensor system for simultaneous and quasi-independent strain and temperature measurements is presented. The interrogation of the sensing head has been carried out by monitoring the FFT phase variations of two of the microstructured optical fiber (MOF) cavity interference frequencies. This method is independent of the signal amplitude and also avoids the need to track the wavelength evolution in the spectrum, which can be a handicap when there are multiple interference frequency components with different sensitivities. The sensor is operated within a range of temperature of 30°C-75°C, and 380μɛ of maximum strain were applied; being the sensitivities achieved of 127.5pm/°C and -19.1pm/μɛ respectively. Because the system uses an optical interrogator as unique active element, the system presents a cost-effective feature.

  17. Component-based assistants for MEMS design tools

    Science.gov (United States)

    Hahn, Kai; Brueck, Rainer; Schneider, Christian; Schumer, Christian; Popp, Jens

    2001-04-01

    With this paper a new approach for MEMS design tools will be introduced. An analysis of the design tool market leads to the result that most of the designers work with large and inflexible frameworks. Purchasing and maintaining these frameworks is expensive, and gives no optimum support for MEMS design process. The concept of design assistants, carried out with the concept of interacting software components, denotes a new generation of flexible, small, semi-autonomous software systems that are used to solve specific MEMS design tasks in close interaction with the designer. The degree of interaction depends on the complexity of the design task to be performed and the possibility to formalize the respective knowledge. In this context the Internet as one of today's most important communication media provides support for new tool concepts on the basis of the Java programming language. These modern technologies can be used to set up distributed and platform-independent applications. Thus the idea emerged to implement design assistants using Java. According to the MEMS design model new process sequences have to be defined new for every specific design object. As a consequence, assistants have to be built dynamically depending on the requirements of the design process, what can be achieved with component based software development. Componentware offers the possibility to realize design assistants, in areas like design rule checks, process consistency checks, technology definitions, graphical editors, etc. that may reside distributed over the Internet, communicating via Internet protocols. At the University of Siegen a directory for reusable MEMS components has been created, containing a process specification assistant and a layout verification assistant for lithography based MEMS technologies.

  18. [Development and application of component-based Chinese medicine theory].

    Science.gov (United States)

    Zhang, Jun-Hua; Fan, Guan-Wei; Zhang, Han; Fan, Xiao-Hui; Wang, Yi; Liu, Li-Mei; Li, Chuan; Gao, Yue; Gao, Xiu-Mei; Zhang, Bo-Li

    2017-11-01

    Traditional Chinese medicine (TCM) prescription is the main therapies for disease prevention and treatment in Chinese medicine. Following the guidance of the theory of TCM and developing drug by composing prescriptions of TCM materials and pieces, it is a traditional application mode of TCM, and still widely used in clinic. TCM prescription has theoretical advantages and rich clinical application experience in dealing with multi-factor complex diseases, but scientific research is relatively weak. The lack of scientific cognition of the effective substances and mechanism of Chinese medicine leads to insufficient understanding of the efficacy regularity, which affects the stability of effect and hinders the improvement of quality of Chinese medicinal products. Component-based Chinese medicine (CCM) is an innovation based on inheritance, which breaks through the tradition of experience-based prescription and realize the transformation of compatibility from herbal pieces to components. CCM is an important achievement during the research process of modernization of Chinese medicine. Under the support of three national "973" projects, in order to reveal the scientific connotation of the prescription compatibility theory and develop innovative Chinese drugs, we have launched theoretical innovation and technological innovation around the "two relatively clear", and opened up the research field of CCM. CCM is an innovation based on inheritance, breaking through the tradition of experience based prescription, and realizing the transformation from compatibility of herbal pieces to component compatibility, which is an important achievement of the modernization of traditional Chinese medicine. In the past more than 10 years, with the deepening of research and the expansion of application, the theory and methods of CCM and efficacy-oriented compatibility have been continuously improved. The value of CCM is not only in developing new drug, more important is to build a

  19. SIFT - A Component-Based Integration Architecture for Enterprise Analytics

    Energy Technology Data Exchange (ETDEWEB)

    Thurman, David A.; Almquist, Justin P.; Gorton, Ian; Wynne, Adam S.; Chatterton, Jack

    2007-02-01

    Architectures and technologies for enterprise application integration are relatively mature, resulting in a range of standards-based and proprietary middleware technologies. In the domain of complex analytical applications, integration architectures are not so well understood. Analytical applications such as those used in scientific discovery, emergency response, financial and intelligence analysis exert unique demands on their underlying architecture. These demands make existing integration middleware inappropriate for use in enterprise analytics environments. In this paper we describe SIFT (Scalable Information Fusion and Triage), a platform designed for integrating the various components that comprise enterprise analytics applications. SIFT exploits a common pattern for composing analytical components, and extends an existing messaging platform with dynamic configuration mechanisms and scaling capabilities. We demonstrate the use of SIFT to create a decision support platform for quality control based on large volumes of incoming delivery data. The strengths of the SIFT solution are discussed, and we conclude by describing where further work is required to create a complete solution applicable to a wide range of analytical application domains.

  20. Integration of Simulink Models with Component-based Software Models

    DEFF Research Database (Denmark)

    Marian, Nicolae

    2008-01-01

    , communication and constraints, using computational blocks and aggregates for both discrete and continuous behaviour, different interconnection and execution disciplines for event-based and time-based controllers, and so on, to encompass the demands to more functionality, at even lower prices, and with opposite...... to be analyzed. One way of doing that is to integrate in wrapper files the model back into Simulink S-functions, and use its extensive simulation features, thus allowing an early exploration of the possible design choices over multiple disciplines. The paper describes a safe translation of a restricted set...... of MATLAB/Simulink blocks to COMDES software components, both for continuous and discrete behaviour, and the transformation of the software system into the S-functions. The general aim of this work is the improvement of multi-disciplinary development of embedded systems with the focus on the relation...

  1. Simultaneous surface and depth neural activity recording with graphene transistor-based dual-modality probes.

    Science.gov (United States)

    Du, Mingde; Xu, Xianchen; Yang, Long; Guo, Yichuan; Guan, Shouliang; Shi, Jidong; Wang, Jinfen; Fang, Ying

    2018-05-15

    Subdural surface and penetrating depth probes are widely applied to record neural activities from the cortical surface and intracortical locations of the brain, respectively. Simultaneous surface and depth neural activity recording is essential to understand the linkage between the two modalities. Here, we develop flexible dual-modality neural probes based on graphene transistors. The neural probes exhibit stable electrical performance even under 90° bending because of the excellent mechanical properties of graphene, and thus allow multi-site recording from the subdural surface of rat cortex. In addition, finite element analysis was carried out to investigate the mechanical interactions between probe and cortex tissue during intracortical implantation. Based on the simulation results, a sharp tip angle of π/6 was chosen to facilitate tissue penetration of the neural probes. Accordingly, the graphene transistor-based dual-modality neural probes have been successfully applied for simultaneous surface and depth recording of epileptiform activity of rat brain in vivo. Our results show that graphene transistor-based dual-modality neural probes can serve as a facile and versatile tool to study tempo-spatial patterns of neural activities. Copyright © 2018 Elsevier B.V. All rights reserved.

  2. Discrete Adjoint-Based Simultaneous Analysis and Design Approach for Conceptual Aerodynamic Optimization

    Directory of Open Access Journals (Sweden)

    Oliviu SUGAR-GABOR

    2017-09-01

    Full Text Available In this paper, a simultaneous analysis and design method is derived and applied for a non-linear constrained aerodynamic optimization problem. The method is based on the approach of defining a Lagrange functional based on the objective function and the aerodynamic model’s equations, using two sets of multipliers. A fully-coupled, non-linear system of equations is derived by requiring that the Gateaux variation of the Lagrange functional vanishes for arbitrary variations of the aerodynamic model’s dependent variables and design parameters. The optimization problem is approached using a one-shot technique, by solving the non-linear system in which all sensitivities and problem constraints are included. The computational efficiency of the method is compared against a gradient-based optimization algorithm using adjoint-provided gradient. A conceptual-stage aerodynamic optimization problem is solved, based on a non-linear numerical lifting-line method with viscous corrections.

  3. Sparse distance-based learning for simultaneous multiclass classification and feature selection of metagenomic data.

    Science.gov (United States)

    Liu, Zhenqiu; Hsiao, William; Cantarel, Brandi L; Drábek, Elliott Franco; Fraser-Liggett, Claire

    2011-12-01

    Direct sequencing of microbes in human ecosystems (the human microbiome) has complemented single genome cultivation and sequencing to understand and explore the impact of commensal microbes on human health. As sequencing technologies improve and costs decline, the sophistication of data has outgrown available computational methods. While several existing machine learning methods have been adapted for analyzing microbiome data recently, there is not yet an efficient and dedicated algorithm available for multiclass classification of human microbiota. By combining instance-based and model-based learning, we propose a novel sparse distance-based learning method for simultaneous class prediction and feature (variable or taxa, which is used interchangeably) selection from multiple treatment populations on the basis of 16S rRNA sequence count data. Our proposed method simultaneously minimizes the intraclass distance and maximizes the interclass distance with many fewer estimated parameters than other methods. It is very efficient for problems with small sample sizes and unbalanced classes, which are common in metagenomic studies. We implemented this method in a MATLAB toolbox called MetaDistance. We also propose several approaches for data normalization and variance stabilization transformation in MetaDistance. We validate this method on several real and simulated 16S rRNA datasets to show that it outperforms existing methods for classifying metagenomic data. This article is the first to address simultaneous multifeature selection and class prediction with metagenomic count data. The MATLAB toolbox is freely available online at http://metadistance.igs.umaryland.edu/. zliu@umm.edu Supplementary data are available at Bioinformatics online.

  4. A Turbidity Test Based Centrifugal Microfluidics Diagnostic System for Simultaneous Detection of HBV, HCV, and CMV

    Directory of Open Access Journals (Sweden)

    Hung-Cheng Chang

    2015-01-01

    Full Text Available This paper presents a LAMP- (loop-mediated isothermal amplification- based lab-on-disk optical system that allows the simultaneous detection of hepatitis B virus, hepatitis C virus, and cytomegalovirus. The various flow stages are controlled in the proposed system using different balance among centrifugal pumping, Coriolis pumping, and the capillary force. We have implemented a servo system for positioning and speed control for the heating and centrifugal pumping. We have also successfully employed a polymer light-emitting diode section for turbidity detection. The easy-to-use one-click system can perform diagnostics in less than 1 hour.

  5. Matlab-based interface for the simultaneous acquisition of force measures and Doppler ultrasound muscular images.

    Science.gov (United States)

    Ferrer-Buedo, José; Martínez-Sober, Marcelino; Alakhdar-Mohmara, Yasser; Soria-Olivas, Emilio; Benítez-Martínez, Josep C; Martínez-Martínez, José M

    2013-04-01

    This paper tackles the design of a graphical user interface (GUI) based on Matlab (MathWorks Inc., MA), a worldwide standard in the processing of biosignals, which allows the acquisition of muscular force signals and images from a ultrasound scanner simultaneously. Thus, it is possible to unify two key magnitudes for analyzing the evolution of muscular injuries: the force exerted by the muscle and section/length of the muscle when such force is exerted. This paper describes the modules developed to finally show its applicability with a case study to analyze the functioning capacity of the shoulder rotator cuff. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  6. A simultaneous job- and task-based exposure evaluation of petroleum tanker drivers to benzene and total hydrocarbons.

    Science.gov (United States)

    Verma, Dave K; Cheng, Wai K; Shaw, Don S; Shaw, M Lorraine; Verma, Paul; Julian, Jim A; Dumschat, Reinhard E; Mulligan, Sharon J P

    2004-11-01

    A simultaneous job- and task-based exposure study was conducted for tanker drivers delivering petroleum products from several bulk terminals and an agency to retail outlets. Full-shift (job-based) samples and job component tasks samples were collected simultaneously. The tasks sampled included loading, unloading, and travel. Three hundred sixty-six personal charcoal tube samples were collected. Full-shift visual observations of work practices and real-time monitoring using a data logging hydrocarbon analyzer were also conducted. Multiple measurements per worker were made, which permitted an assessment of sampling variability within and between workers. The highest exposures for drivers occurred during unloading at the agency. The mean benzene exposure for agency drivers was 0.88 ppm for full-shift time-weighted average, 2.86 ppm for unloading, and 0.54 ppm for loading. For bulk terminal drivers, the mean benzene level without vapor control was 0.12 ppm for time weighted average, 0.24 ppm for unloading, and 0.33 ppm for loading. The time-weighted average exposure of the agency and bulk terminal drivers based on the data collected and the lognormal model can be expected to exceed threshold limit value-time weighted average of 0.5 ppm for benzene about 70 and 2% of the time, respectively. Agency drivers' unloading and loading tasks accounted for approximately 30% and 7% of the total time, and 95% and 4% of total exposure, respectively. For the bulk terminal drivers, mean unloading and loading tasks constituted 24% and 12% of the total time, and 68% and 19% of the total exposure, respectively. Travel activity accounted for an average of 63% of the total time for agency and 64% for bulk terminal drivers, but only contributed agencies. Vapor control technology at the terminal effectively reduces exposure (by almost 50%) and fugitive emissions.

  7. Modelling raster-based monthly water balance components for Europe

    Energy Technology Data Exchange (ETDEWEB)

    Ulmen, C.

    2000-11-01

    The terrestrial runoff component is a comparatively small but sensitive and thus significant quantity in the global energy and water cycle at the interface between landmass and atmosphere. As opposed to soil moisture and evapotranspiration which critically determine water vapour fluxes and thus water and energy transport, it can be measured as an integrated quantity over a large area, i.e. the river basin. This peculiarity makes terrestrial runoff ideally suited for the calibration, verification and validation of general circulation models (GCMs). Gauging stations are not homogeneously distributed in space. Moreover, time series are not necessarily continuously measured nor do they in general have overlapping time periods. To overcome this problems with regard to regular grid spacing used in GCMs, different methods can be applied to transform irregular data to regular so called gridded runoff fields. The present work aims to directly compute the gridded components of the monthly water balance (including gridded runoff fields) for Europe by application of the well-established raster-based macro-scale water balance model WABIMON used at the Federal Institute of Hydrology, Germany. Model calibration and validation is performed by separated examination of 29 representative European catchments. Results indicate a general applicability of the model delivering reliable overall patterns and integrated quantities on a monthly basis. For time steps less then too weeks further research and structural improvements of the model are suggested. (orig.)

  8. A Parcellation Based Nonparametric Algorithm for Independent Component Analysis with Application to fMRI Data

    Directory of Open Access Journals (Sweden)

    Shanshan eLi

    2016-01-01

    Full Text Available Independent Component analysis (ICA is a widely used technique for separating signals that have been mixed together. In this manuscript, we propose a novel ICA algorithm using density estimation and maximum likelihood, where the densities of the signals are estimated via p-spline based histogram smoothing and the mixing matrix is simultaneously estimated using an optimization algorithm. The algorithm is exceedingly simple, easy to implement and blind to the underlying distributions of the source signals. To relax the identically distributed assumption in the density function, a modified algorithm is proposed to allow for different density functions on different regions. The performance of the proposed algorithm is evaluated in different simulation settings. For illustration, the algorithm is applied to a research investigation with a large collection of resting state fMRI datasets. The results show that the algorithm successfully recovers the established brain networks.

  9. Tip displacement variance of manipulator to simultaneous horizontal and vertical stochastic base excitations

    International Nuclear Information System (INIS)

    Rahi, A.; Bahrami, M.; Rastegar, J.

    2002-01-01

    The tip displacement variance of an articulated robotic manipulator to simultaneous horizontal and vertical stochastic base excitation is studied. The dynamic equations for an n-links manipulator subjected to both horizontal and vertical stochastic excitations are derived by Lagrangian method and decoupled for small displacement of joints. The dynamic response covariance of the manipulator links is computed in the coordinate frame attached to the base and then the principal variance of tip displacement is determined. Finally, simulation for a two-link planner robotic manipulator under base excitation is developed. Then sensitivity of the principal variance of tip displacement and tip velocity to manipulator configuration, damping, excitation parameters and manipulator links length are investigated

  10. Component-based analysis of embedded control applications

    DEFF Research Database (Denmark)

    Angelov, Christo K.; Guan, Wei; Marian, Nicolae

    2011-01-01

    The widespread use of embedded systems requires the creation of industrial software technology that will make it possible to engineer systems being correct by construction. That can be achieved through the use of validated (trusted) components, verification of design models, and automatic...... instances of reusable, executable components—function blocks (FBs). System actors operate in accordance with a timed multitasking model of computation, whereby I/O signals are exchanged with the controlled plant at precisely specified time instants, resulting in the elimination of I/O jitter. The paper...... a feasible (light-weight) analysis method based on runtime observers. The latter are conceived as special-purpose actors running in parallel with the application actors, while checking system properties specified in Linear Temporal Logic. Observers are configured from reusable FBs that can be exported...

  11. High Q, Miniaturized LCP-Based Passive Components

    KAUST Repository

    Shamim, Atif

    2014-10-16

    Various methods and systems are provided for high Q, miniaturized LCP-based passive components. In one embodiment, among others, a spiral inductor includes a center connection and a plurality of inductors formed on a liquid crystal polymer (LCP) layer, the plurality of inductors concentrically spiraling out from the center connection. In another embodiment, a vertically intertwined inductor includes first and second inductors including a first section disposed on a side of the LCP layer forming a fraction of a turn and a second section disposed on another side of the LCP layer. At least a portion of the first section of the first inductor is substantially aligned with at least a portion of the second section of the second inductor and at least a portion of the first section of the second inductor is substantially aligned with at least a portion of the second section of the first inductor.

  12. Multiple-input multiple-output visible light communication system based on disorder dispersion components

    Science.gov (United States)

    Yang, Tao; Zhang, Qi; Hao, Yue; Zhou, Xin-hui; Yi, Ming-dong; Wei, Wei; Huang, Wei; Li, Xing-ao

    2017-10-01

    A multiple-input multiple-output visible light communication (VLC) system based on disorder dispersion components is presented. Instead of monochromatic sources and large size photodetectors used in the traditional VLC systems, broadband sources with different spectra act as the transmitters and a compact imaging chip sensor accompanied by a disorder dispersion component and a calculating component serve as the receivers in the proposed system. This system has the merits of small size, more channels, simple structure, easy integration, and low cost. Simultaneously, the broadband sources are suitable to act as illumination sources for their white color. A regularized procedure is designed to solve a matrix equation for decoding the signals at the receivers. A proof-of-concept experiment using on-off keying modulation has been done to prove the feasibility of the design. The experimental results show that the signals decoded by the receivers fit well with those generated from the transmitters, but the bit error ratio is increased with the number of the signal channels. The experimental results can be further improved using a high-speed charge-coupled device, decreasing noises, and increasing the distance between the transmitters and the receivers.

  13. Optical fiber-based full Mueller polarimeter for endoscopic imaging using a two-wavelength simultaneous measurement method.

    Science.gov (United States)

    Vizet, Jérémy; Manhas, Sandeep; Tran, Jacqueline; Validire, Pierre; Benali, Abdelali; Garcia-Caurel, Enric; Pierangelo, Angelo; De Martino, Antonello; Pagnoux, Dominique

    2016-07-01

    This paper reports a technique based on spectrally differential measurement for determining the full Mueller matrix of a biological sample through an optical fiber. In this technique, two close wavelengths were used simultaneously, one for characterizing the fiber and the other for characterizing the assembly of fiber and sample. The characteristics of the fiber measured at one wavelength were used to decouple its contribution from the measurement on the assembly of fiber and sample and then to extract sample Mueller matrix at the second wavelength. The proof of concept was experimentally validated by measuring polarimetric parameters of various calibrated optical components through the optical fiber. Then, polarimetric images of histological cuts of human colon tissues were measured, and retardance, diattenuation, and orientation of the main axes of fibrillar regions were displayed. Finally, these images were successfully compared with images obtained by a free space Mueller microscope. As the reported method does not use any moving component, it offers attractive integration possibilities with an endoscopic probe.

  14. A novel ion-pairing chromatographic method for the simultaneous determination of both nicarbazin components in feed additives: chemometric tools for improving the optimization and validation.

    Science.gov (United States)

    De Zan, María M; Teglia, Carla M; Robles, Juan C; Goicoechea, Héctor C

    2011-07-15

    The development, optimization and validation of an ion-pairing high performance liquid chromatography method for the simultaneous determination of both nicarbazin (NIC) components: 4,4'-dinitrocarbanilide (DNC) and 2-hydroxy-4,6-dimethylpyrimidine (HDP) in bulk materials and feed additives are described. An experimental design was used for the optimization of the chromatographic system. Four variables, including mobile phase composition and oven temperature, were analyzed through a central composite design exploring their contribution to analyte separation. Five responses: peak resolutions, HDP capacity factor, HDP tailing and analysis time, were modelled by using the response surface methodology and were optimized simultaneously by implementing the desirability function. The optimum conditions resulted in a mobile phase consisting of 10.0 mmol L(-1) of 1-heptanesulfonate, 20.0 mmol L(-1) of sodium acetate, pH=3.30 buffer and acetonitrile in a gradient system at a flow rate of 1.00 mL min(-1). Column was an INERSTIL ODS-3 (4.6 mm×150 mm, 5 μm particle size) at 40.0°C. Detection was performed at 300 nm by a diode array detector. The validation results of the method indicated a high selectivity and good precision characteristics, with RSD less than 1.0% for both components, both in intra and inter-assay precision studies. Linearity was proved for a range of 32.0-50.0 μg mL(-1) of NIC in sample solution. The recovery, studied at three different fortification levels, varied from 98.0 to 101.4 for HDP and from 99.1 to 100.2 for DNC. The applicability of the method was demonstrated by determining DNC and HDP content in raw materials and commercial formulations used for coccidiosis prevention. Assays results on real samples showed that considerable differences in molecular ratio DNC:HDP exist among them. Copyright © 2011 Elsevier B.V. All rights reserved.

  15. State‐of‐the‐art and progress in the optimization‐based simultaneous design and control for chemical processes

    DEFF Research Database (Denmark)

    Yuan, Zhihong; Chen, Bingzhen; Sin, Gürkan

    2012-01-01

    Significant progress in the area of simultaneous design and control for chemical processes has been achieved and various methodologies have been put forward to address this issue over the last several decades. These methods can be classified in two categories (1) controllability indicator......‐based frameworks that are capable of screening alternative designs, and (2) optimization‐based frameworks that integrate the process design and control system design. The major objective is to give an up‐to‐date review of the state‐of‐the‐art and progress in the challenging area of optimization‐based simultaneous...... design and control. First, motivations and significances of simultaneous design and control are illustrated. Second, a general classification of existing methodologies of optimization‐based simultaneous design and control is outlined. Subsequently, the mathematical formulations and relevant theoretical...

  16. Simultaneous Elimination of Soot and NOX through Silver-Barium Based Catalytic Materials

    Directory of Open Access Journals (Sweden)

    Ganesh Chandra Dhal

    2017-04-01

    Full Text Available In this research paper, the nanometric size effect, the effects of the intrinsic factors including structure, and the redox properties of three systems of nanometric of silver-based catalysts were summarized. In this work, these catalysts were investigated for the simultaneous removal of particulate matter (diesel soot, and NOX was compared with that of a model of Pt-Ba/Al2O3 catalyst. The Silver-Barium based catalytic materials of Ag (5 wt%-Ba(10 wt%/MO (MO=Al2O3, CeO2, ZrO2, and Ag (5 wt%-Sr (10 wt%/CeO2 catalysts have been prepared by wetness impregnation method and characterized by BET, XRD, HRTEM, XPS and TPR (temperature-programmed reduction experiments. The behavior of the catalyst in the soot combustion (under tight conditions and NOX elimination has been separately analyzed by means of temperature programmed oxidation and isothermal concentration step change experiments, respectively. The results showed that all the catalysts were active in soot combustion with an indicative decrease of oxidation onset temperature compared to uncatalyzed soot oxidation. The removal of NOX in the presence and in the absence of soot was investigated under cycling conditions, i.e. alternating lean-rich phases according to the LNT approach. It has been found that the Ag-based samples were able to simultaneously remove soot and NOX. In particular, studying the behavior of the prepared catalysts, the Ba-containing systems exhibited higher NOX storage capacity than Sr-catalyst; also, the nitrogen selectivity increased even if resulted lower than the traditional LNT Pt-based catalyst. An adverse effect of soot on the NOX storage activity has been also observed. Copyright © 2017 BCREC GROUP. All rights reserved Received: 18th August 2016; Revised: 19th October 2016; Accepted: 19th October 2016 How to Cite: Dhal, G.C., Dey, S., Prasad, R., Mohan, D. (2017. Simultaneous Elimination of Soot and NOX through Silver-Barium Based Catalytic Materials. Bulletin of

  17. Independent Component Analysis applied to Ground-based observations

    Science.gov (United States)

    Martins-Filho, Walter; Griffith, Caitlin; Pearson, Kyle; Waldmann, Ingo; Alvarez-Candal, Alvaro; Zellem, Robert Thomas

    2018-01-01

    Transit measurements of Jovian-sized exoplanetary atmospheres allow one to study the composition of exoplanets, largely independent of the planet’s temperature profile. However, measurements of hot-Jupiter transits must archive a level of accuracy in the flux to determine the spectral modulation of the exoplanetary atmosphere. To accomplish this level of precision, we need to extract systematic errors, and, for ground-based measurements, the effects of Earth’s atmosphere, from signal due to the exoplanet, which is several orders of magnitude smaller. The effects of the terrestrial atmosphere and some of the time-dependent systematic errors of ground-based transit measurements are treated mainly by dividing the host star by a reference star at each wavelength and time step of the transit. Recently, Independent Component Analysis (ICA) have been used to remove systematics effects from the raw data of space-based observations (Waldmann, 2014, 2012; Morello et al., 2016, 2015). ICA is a statistical method born from the ideas of the blind-source separations studies, which can be used to de-trend several independent source signals of a data set (Hyvarinen and Oja, 2000). This technique requires no additional prior knowledge of the data set. In addition, this technique has the advantage of requiring no reference star. Here we apply the ICA to ground-based photometry of the exoplanet XO-2b recorded by the 61” Kuiper Telescope and compare the results of the ICA to those of a previous analysis from Zellem et al. (2015), which does not use ICA. We also simulate the effects of various conditions (concerning the systematic errors, noise and the stability of object on the detector) to determine the conditions under which an ICA can be used with high precision to extract the light curve of exoplanetary photometry measurements

  18. Evaluating the hydrological consistency of satellite based water cycle components

    KAUST Repository

    Lopez Valencia, Oliver Miguel

    2016-06-15

    Advances in multi-satellite based observations of the earth system have provided the capacity to retrieve information across a wide-range of land surface hydrological components and provided an opportunity to characterize terrestrial processes from a completely new perspective. Given the spatial advantage that space-based observations offer, several regional-to-global scale products have been developed, offering insights into the multi-scale behaviour and variability of hydrological states and fluxes. However, one of the key challenges in the use of satellite-based products is characterizing the degree to which they provide realistic and representative estimates of the underlying retrieval: that is, how accurate are the hydrological components derived from satellite observations? The challenge is intrinsically linked to issues of scale, since the availability of high-quality in-situ data is limited, and even where it does exist, is generally not commensurate to the resolution of the satellite observation. Basin-scale studies have shown considerable variability in achieving water budget closure with any degree of accuracy using satellite estimates of the water cycle. In order to assess the suitability of this type of approach for evaluating hydrological observations, it makes sense to first test it over environments with restricted hydrological inputs, before applying it to more hydrological complex basins. Here we explore the concept of hydrological consistency, i.e. the physical considerations that the water budget impose on the hydrologic fluxes and states to be temporally and spatially linked, to evaluate the reproduction of a set of large-scale evaporation (E) products by using a combination of satellite rainfall (P) and Gravity Recovery and Climate Experiment (GRACE) observations of storage change, focusing on arid and semi-arid environments, where the hydrological flows can be more realistically described. Our results indicate no persistent hydrological

  19. A One-Structure-Based Multieffects Coupled Nanogenerator for Simultaneously Scavenging Thermal, Solar, and Mechanical Energies.

    Science.gov (United States)

    Ji, Yun; Zhang, Kewei; Yang, Ya

    2018-02-01

    Rapid advances in various energy harvesters impose the challenge on integrating them into one device structure with synergetic effects for full use of the available energies from the environment. Here, a multieffect coupled nanogenerator based on ferroelectric barium titanate is reported. It promotes the ability to simultaneously scavenging thermal, solar, and mechanical energies. By integration of a pyroelectric nanogenerator, a photovoltaic cell, and a triboelectric-piezoelectric nanogenerator in one structure with only two electrodes, multieffects interact with each other to alter the electric output, and a complementary power source with peak current of ≈1.5 µA, peak voltage of ≈7 V, and platform voltage of ≈6 V is successfully achieved. Compared with traditional hybridized nanogenerators with stacked architectures, the one-structure-based multieffects coupled nanogenerator is smaller, simpler, and less costly, showing prospective in practical applications and represents a new trend of all-in-one multiple energy scavenging.

  20. The Effect of Inoculation with Azotobacter and Nitrogen Levels on Grain and Corn Yield Components at Simultaneous Cropping System with Legumes

    Directory of Open Access Journals (Sweden)

    mohammad mirzakhani

    2017-09-01

    Full Text Available Introduction: Corn has been regarded as one of the important crops from the view point of both human and animal feeding resource. Intercropping defined as cultivation of two or more species together. The advantages of intercropping can be included: efficient use of water and sunlight, exchange of nutrients, weed competition reduction, reduction of pathogens and the increase of soil fertility. Research shows that intercropping combinations of legume–grass will increase forage quality. Because, grasses Grains have a lot of carbohydrates and legumes are rich in protein and vitamins. This study was conducted to evaluate the effect of inoculation with azotobacter and nitrogen levels on grain and corn yield components at simultaneous cropping system with legumes under the weather conditions of Markazi province. Materials and methods: This study was carried out at agricultural research field of Payame Noor University, Arak Branch during 2011. A factorial arrangement of treatment in a randomized complete block design with three replications was used. Methods of plant nutrition (M0= inoculation with azotobacter, M1= inoculation with azotobacter + 37/5 Kg ha-1 of rare nitrogen with foliar application method, M2= inoculation with azotobacter + 150 Kg ha-1 of rare nitrogen mix with soil and simultaneous cropping treatment of legumes, [S1= corn + alfalfa (Medicago sativa L., S2= corn + bitter vetch (Lathyrus sativus L., S3= corn + mung bean (Vigna radiata L., S4= corn + chickpea (Cicer arientinum L., S5= corn + vetch (Vicia ervillia L. ] were assigned in plots. Each sub plot consisted of 4 rows, 6 m long with 60 cm between rows space and 20 cm between plants on the rows and S.C Apex hybrid was used. In this study characteristics such as: plant height, earing height, the number of grains per m-2, the number of rows per ear, the number of grains per row, surface of ear leaf, grain yield of corn, 1000 grain weight, harvest index of corn, nitrogen use

  1. A Recurrent Probabilistic Neural Network with Dimensionality Reduction Based on Time-series Discriminant Component Analysis.

    Science.gov (United States)

    Hayashi, Hideaki; Shibanoki, Taro; Shima, Keisuke; Kurita, Yuichi; Tsuji, Toshio

    2015-12-01

    This paper proposes a probabilistic neural network (NN) developed on the basis of time-series discriminant component analysis (TSDCA) that can be used to classify high-dimensional time-series patterns. TSDCA involves the compression of high-dimensional time series into a lower dimensional space using a set of orthogonal transformations and the calculation of posterior probabilities based on a continuous-density hidden Markov model with a Gaussian mixture model expressed in the reduced-dimensional space. The analysis can be incorporated into an NN, which is named a time-series discriminant component network (TSDCN), so that parameters of dimensionality reduction and classification can be obtained simultaneously as network coefficients according to a backpropagation through time-based learning algorithm with the Lagrange multiplier method. The TSDCN is considered to enable high-accuracy classification of high-dimensional time-series patterns and to reduce the computation time taken for network training. The validity of the TSDCN is demonstrated for high-dimensional artificial data and electroencephalogram signals in the experiments conducted during the study.

  2. Simultaneous spectrophotometric determination of Fe and Ni with xylenol orange using principal component analysis and artificial neural networks in some industrial samples.

    Science.gov (United States)

    Kompany-Zareh, M; Massoumi, A; Pezeshk-Zadeh, S

    1999-02-01

    Artificial neural networks (ANNs) are among the most popular techniques for nonlinear multivariate calibration in complicated mixtures using spectrophotometric data. In this study, Fe and Ni were simultaneously determined in aqueous medium with xylenol orange (XO) at pH 4.0. In this way, after reducing the number of spectral data using principal component analysis (PCA), an artificial neural network consisting of three layers of nodes was trained by applying a back-propagation learning rule. Sigmoid transfer functions were used in the hidden and output layers to facilitate nonlinear calibration. Adjustable experimental and network parameters were optimized, 30 calibration and 20 prediction samples were prepared over the concentration ranges of 0-400 mug l(-1) Fe and 0-300 mug l(-1) Ni. The resulting R.S.E. of prediction (S.E.P.) of 3.8 and 4.7% for Fe and Ni were obtained, respectively. The method has been applied to the spectrophotometric determination of Fe and Ni in synthetic samples, some Ni alloys, and some industrial waste waters.

  3. Simultaneous Optimization of Block Replacement and Spare Part Ordering Time for a Multi Component System with Separate Spare Part Ordering for Block and Failure Replacements

    Directory of Open Access Journals (Sweden)

    Farid Mardin

    2016-11-01

    Full Text Available A block replacement schedule can be optimized simultaneously with a spare parts ordering schedule, since all items are replaced at a constant interval. The solution of joint optimization for spare parts ordering time and block replacement gives lower costs compared to separate optimization of ordering time and replacement time. The spare parts for replacement can be classified as stochastic demand for failure replacement and deterministic demand for block replacement. In this paper, we propose a simulation model for a separate spare parts ordering schedule. The solution was compared to the solution for a model with common spare parts for both failure and block replacement. The system has N identical components, each with a Weibull lifetime distribution. The costs of failure and block replacements, and also the costs of ordering, holding and shortage of spare parts are given. The proposed model was shown to perform better than the common order model. Also, compared to the age replacement model, the solution of the proposed model is relatively similar, yet the economies of scale would be an advantage for the block replacement over age replacement.

  4. Simultaneous spectrophotometric determination of tartrazine, patent blue V, and indigo carmine in commercial products by partial least squares and principal component regression methods.

    Science.gov (United States)

    Nevado, J J; Flores, J R; Llerena, M J; Fariñas, N R

    1999-04-01

    Two multivariate calibration methods, partial least squares (PLS-1) and principal component regression (PCR) were proposed and successfully applied to the simultaneous determination of three dyes, tartrazine (T) (E-102), patent blue V (P) (E-131), and indigo carmine (I) (E-132) in mixtures by ultraviolet-visible absorption spectrophotometry. Calibration models were evaluated by internal validation (prediction of dyes concentration in its own designed training set of calibration), by cross-validation (obtaining statistical parameters that show the efficiency for a calibration fit model), and by external validation over 19 synthetic mixtures of the three dyes in different ratios containing 2.4-17.6 mg l(-1) of T, 1.6-5.6 mg l(-1) of P, and 3.2-17.5 mg/l(-1) of I, with recoveries between 93.5 and 103.1% and over three commercial products, in which the proposed calibration models were satisfactorily applied without separation step. Repeatability and reproducibility studies (with the Students's and F tests) were achieved over two series of nine standards for each dye, showing no significant differences at 95% confidence level.

  5. Volatile components and key odorants of fennel (Foeniculum vulgare Mill.) and thyme (Thymus vulgaris L.) oil extracts obtained by simultaneous distillation-extraction and supercritical fluid extraction.

    Science.gov (United States)

    Díaz-Maroto, M Consuelo; Díaz-Maroto Hidalgo, Ignacio Javier; Sánchez-Palomo, Eva; Pérez-Coello, M Soledad

    2005-06-29

    Volatile oil extracts of fennel seeds (Foeniculum vulgare Mill.) and thyme leaves (Thymus vulgaris L.) were obtained by simultaneous distillation-extraction (SDE) and supercritical fluid extraction (SFE) and analyzed by gas chromatography-mass spectrometry (GC-MS). In general, fennel oil extracted by SDE and SFE showed similar compositions, with trans-anethole, estragole, and fenchone as the main components. In contrast, thymol and p-cymene, the most abundant compounds in thyme leaves, showed big differences, with generally higher amounts of monoterpenes obtained by SDE. However, in this case, the differences between the extracts were higher. Key odorants of fennel seeds determined by gas chromatography-olfactometry (GC-O) showed similar patterns when applying SDE and SFE. trans-Anethole (anise, licorice), estragole (anise, licorice, sweet), fenchone (mint, camphor, warm), and 1-octen-3-ol (mushroom) were the most intense odor compounds detected in fennel extracts. Thymol and carvacrol, with oregano, thyme, and spicy notes, were identified as key compounds contributing to the aroma of thyme leaves.

  6. Application of fuzzy-MOORA method: Ranking of components for reliability estimation of component-based software systems

    Directory of Open Access Journals (Sweden)

    Zeeshan Ali Siddiqui

    2016-01-01

    Full Text Available Component-based software system (CBSS development technique is an emerging discipline that promises to take software development into a new era. As hardware systems are presently being constructed from kits of parts, software systems may also be assembled from components. It is more reliable to reuse software than to create. It is the glue code and individual components reliability that contribute to the reliability of the overall system. Every component contributes to overall system reliability according to the number of times it is being used, some components are of critical usage, known as usage frequency of component. The usage frequency decides the weight of each component. According to their weights, each component contributes to the overall reliability of the system. Therefore, ranking of components may be obtained by analyzing their reliability impacts on overall application. In this paper, we propose the application of fuzzy multi-objective optimization on the basis of ratio analysis, Fuzzy-MOORA. The method helps us find the best suitable alternative, software component, from a set of available feasible alternatives named software components. It is an accurate and easy to understand tool for solving multi-criteria decision making problems that have imprecise and vague evaluation data. By the use of ratio analysis, the proposed method determines the most suitable alternative among all possible alternatives, and dimensionless measurement will realize the job of ranking of components for estimating CBSS reliability in a non-subjective way. Finally, three case studies are shown to illustrate the use of the proposed technique.

  7. Simultaneous allocation of distributed resources using improved teaching learning based optimization

    International Nuclear Information System (INIS)

    Kanwar, Neeraj; Gupta, Nikhil; Niazi, K.R.; Swarnkar, Anil

    2015-01-01

    Highlights: • Simultaneous allocation of distributed energy resources in distribution networks. • Annual energy loss reduction is optimized using a multi-level load profile. • A new penalty factor approach is suggested to check node voltage deviations. • An improved TLBO is proposed by suggesting several modifications in standard TLBO. • An intelligent search is proposed to enhance the performance of solution technique. - Abstract: Active and reactive power flow in distribution networks can be effectively controlled by optimally placing distributed resources like shunt capacitors and distributed generators. This paper presents improved variant of Teaching Learning Based Optimization (TLBO) to efficiently and effectively deal with the problem of simultaneous allocation of these distributed resources in radial distribution networks while considering multi-level load scenario. Several algorithm specific modifications are suggested in the standard form of TLBO to cope against the intrinsic flaws of this technique. In addition, an intelligent search approach is proposed to restrict the problem search space without loss of diversity. This enhances the overall performance of the proposed method. The proposed method is investigated on IEEE 33-bus, 69-bus and 83-bus test distribution systems showing promising results

  8. Multi-Frequency Polarimetric SAR Classification Based on Riemannian Manifold and Simultaneous Sparse Representation

    Directory of Open Access Journals (Sweden)

    Fan Yang

    2015-07-01

    Full Text Available Normally, polarimetric SAR classification is a high-dimensional nonlinear mapping problem. In the realm of pattern recognition, sparse representation is a very efficacious and powerful approach. As classical descriptors of polarimetric SAR, covariance and coherency matrices are Hermitian semidefinite and form a Riemannian manifold. Conventional Euclidean metrics are not suitable for a Riemannian manifold, and hence, normal sparse representation classification cannot be applied to polarimetric SAR directly. This paper proposes a new land cover classification approach for polarimetric SAR. There are two principal novelties in this paper. First, a Stein kernel on a Riemannian manifold instead of Euclidean metrics, combined with sparse representation, is employed for polarimetric SAR land cover classification. This approach is named Stein-sparse representation-based classification (SRC. Second, using simultaneous sparse representation and reasonable assumptions of the correlation of representation among different frequency bands, Stein-SRC is generalized to simultaneous Stein-SRC for multi-frequency polarimetric SAR classification. These classifiers are assessed using polarimetric SAR images from the Airborne Synthetic Aperture Radar (AIRSAR sensor of the Jet Propulsion Laboratory (JPL and the Electromagnetics Institute Synthetic Aperture Radar (EMISAR sensor of the Technical University of Denmark (DTU. Experiments on single-band and multi-band data both show that these approaches acquire more accurate classification results in comparison to many conventional and advanced classifiers.

  9. Simultaneous aptasensor for multiplex pathogenic bacteria detection based on multicolor upconversion nanoparticles labels.

    Science.gov (United States)

    Wu, Shijia; Duan, Nuo; Shi, Zhao; Fang, Congcong; Wang, Zhouping

    2014-03-18

    A highly sensitive and specific multiplex method for the simultaneous detection of three pathogenic bacteria was fabricated using multicolor upconversion nanoparticles (UCNPs) as luminescence labels coupled with aptamers as the molecular recognition elements. Multicolor UCNPs were synthesized via doping with various rare-earth ions to obtain well-separated emission peaks. The aptamer sequences were selected using the systematic evolution of ligands by exponential enrichment (SELEX) strategy for Staphylococcus aureus, Vibrio parahemolyticus, and Salmonella typhimurium. When applied in this method, aptamers can be used for the specific recognition of the bacteria from complex mixtures, including those found in real food matrixes. Aptamers and multicolor UCNPs were employed to selectively capture and simultaneously quantify the three target bacteria on the basis of the independent peaks. Under optimal conditions, the correlation between the concentration of three bacteria and the luminescence signal was found to be linear from 50-10(6) cfu mL(-1). Improved by the magnetic separation and concentration effect of Fe3O4 magnetic nanoparticles, the limits of detection of the developed method were found to be 25, 10, and 15 cfu mL(-1) for S. aureus, V. parahemolyticus, and S. typhimurium, respectively. The capability of the bioassay in real food samples was also investigated, and the results were consistent with experimental results obtained from plate-counting methods. This proposed method for the detection of various pathogenic bacteria based on multicolor UCNPs has great potential in the application of food safety and multiplex nanosensors.

  10. A Novel Hard Decision Based Simultaneous Target Tracking and Classification Approach

    Science.gov (United States)

    Hui, Meng; Wu, Qisheng

    2018-01-01

    Methods dealing with the problem of Joint Tracking and Classification (JTC) are abundant, among which Simultaneous Tracking and Classification (STC) provides a modularized scheme solving tracking and classification subproblems simultaneously. However, there is no explicit hard decision on the class label but only soft decision (class probability) is provided. This does not fit many practical cases, in which a hard decision is urgently needed. To solve this problem, this paper proposes a Hard decision-based STC (HSTC) method. HSTC takes all the decision error rate, timeliness, and estimation error into account. Specifically, for decision, the sequential probability ratio test is adopted due to its nice properties and also the adaptability to our situation. For estimation, by utilizing the two-way information exchange between the tracker and the classifier, we propose flexible three tracking schemes related to decision. The HSTC tracking result is divided into three parts according to the time of making the hard decision. In general, the proposed HSTC method takes advantage of both SPRT and STC. Finally, two illustrative JTC examples with hard decision verify the effectiveness of the the proposed HSTC method. They show that HSTC can meet the demand of the problem, and also has the performance superiority in both decision and estimation. PMID:29463046

  11. Brittleness index calculation and evaluation for CBM reservoirs based on AVO simultaneous inversion

    Science.gov (United States)

    Wu, Haibo; Dong, Shouhua; Huang, Yaping; Wang, Haolong; Chen, Guiwu

    2016-11-01

    In this paper, a new approach is proposed for coalbed methane (CBM) reservoir brittleness index (BI) calculations. The BI, as a guide for fracture area selection, is calculated by dynamic elastic parameters (dynamic Young's modulus Ed and dynamic Poisson's ratio υd) obtained from an amplitude versus offset (AVO) simultaneous inversion. Among the three different classes of CBM reservoirs distinguished on the basis of brittleness in the theoretical part of this study, class I reservoirs with high BI values are identified as preferential target areas for fracturing. Therefore, we derive the AVO approximation equation expressed by Ed and υd first. This allows the direct inversion of the dynamic elastic parameters through the pre-stack AVO simultaneous inversion, which is based on Bayes' theorem. Thereafter, a test model with Gaussian white noise and a through-well seismic profile inversion is used to demonstrate the high reliability of the inversion parameters. Accordingly, the BI of a CBM reservoir section from the Qinshui Basin is calculated using the proposed method and a class I reservoir section detected through brittleness evaluation. From the outcome of this study, we believe the adoption of this new approach could act as a guide and reference for BI calculations and evaluations of CBM reservoirs.

  12. Penning plasma based simultaneous light emission source of visible and VUV lights

    Energy Technology Data Exchange (ETDEWEB)

    Vyas, G. L., E-mail: glvyas27@gmail.com [Manipal University Jaipur (India); Prakash, R.; Pal, U. N. [CSIR-Central Electronics and Engineering Research Institute, Microwave Tubes Division (India); Manchanda, R. [Institute for Plasma Research (India); Halder, N. [Manipal University Jaipur (India)

    2016-06-15

    In this paper, a laboratory-based penning plasma discharge source is reported which has been developed in two anode configurations and is able to produce visible and VUV lights simultaneously. The developed source has simultaneous diagnostics facility using Langmuir probe and optical emission spectroscopy. The two anode configurations, namely, double ring and rectangular configurations, have been studied and compared for optimum use of the geometry for efficient light emissions and recording. The plasma is produced using helium gas and admixture of three noble gases including helium, neon, and argon. The source is capable to produce eight spectral lines for pure helium in the VUV range from 20 to 60 nm and total 24 spectral lines covering the wavelength range 20–106 nm for the admixture of gases. The large range of VUV lines is generated from gaseous admixture rather from the sputtered materials. The recorded spectrum shows that the plasma light radiations in both visible and VUV range are larger in double ring configuration than that of the rectangular configurations at the same discharge operating conditions. To clearly understand the difference, the imaging of the discharge using ICCD camera and particle-in-cell simulation using VORPAL have also been carried out. The effect of ion diffusion, metastable collision with the anode wall and the nonlinear effects are correlated to explain the results.

  13. Coal enterprise risk based on information diffusion of main components

    Energy Technology Data Exchange (ETDEWEB)

    Lu Jie; Jiang Zhong-an; Wan Shan-fu [University of Science and Technology Beijing, Beijing (China). School of Civil and Environment Engineering

    2008-04-15

    An early warning target system of the risk of a coal enterprise is presented which gives an arithmetic method of condensing the initial targets into main components targets by the main components analysis method. The information diffusion theory is used to estimate the number of coal enterprise risk early warnings. This method diffuses the information contained in the data of main components targets into all the points where a risk may occur. The input of the method is the condensed main components targets, the output is the expected warning signal vector. 5 refs., 1 fig., 2 tabs.

  14. Prototype development of an electrical impedance based simultaneous respiratory and cardiac monitoring system for gated radiotherapy.

    Science.gov (United States)

    Kohli, Kirpal; Liu, Jeff; Schellenberg, Devin; Karvat, Anand; Parameswaran, Ash; Grewal, Parvind; Thomas, Steven

    2014-10-14

    In radiotherapy, temporary translocations of the internal organs and tumor induced by respiratory and cardiac activities can undesirably lead to significantly lower radiation dose on the targeted tumor but more harmful radiation on surrounding healthy tissues. Respiratory and cardiac gated radiotherapy offers a potential solution for the treatment of tumors located in the upper thorax. The present study focuses on the design and development of simultaneous acquisition of respiratory and cardiac signal using electrical impedance technology for use in dual gated radiotherapy. An electronic circuitry was developed for monitoring the bio-impedance change due to respiratory and cardiac motions and extracting the cardiogenic ECG signal. The system was analyzed in terms of reliability of signal acquisition, time delay, and functionality in a high energy radiation environment. The resulting signal of the system developed was also compared with the output of the commercially available Real-time Position Management™ (RPM) system in both time and frequency domains. The results demonstrate that the bioimpedance-based method can potentially provide reliable tracking of respiratory and cardiac motion in humans, alternative to currently available methods. When compared with the RPM system, the impedance-based system developed in the present study shows similar output pattern but different sensitivities in monitoring different respiratory rates. The tracking of cardiac motion was more susceptible to interference from other sources than respiratory motion but also provided synchronous output compared with the ECG signal extracted. The proposed hardware-based implementation was observed to have a worst-case time delay of approximately 33 ms for respiratory monitoring and 45 ms for cardiac monitoring. No significant effect on the functionality of the system was observed when it was tested in a radiation environment with the electrode lead wires directly exposed to high-energy X

  15. Simultaneous multicopter-based air sampling and sensing of meteorological variables

    Science.gov (United States)

    Brosy, Caroline; Krampf, Karina; Zeeman, Matthias; Wolf, Benjamin; Junkermann, Wolfgang; Schäfer, Klaus; Emeis, Stefan; Kunstmann, Harald

    2017-08-01

    The state and composition of the lowest part of the planetary boundary layer (PBL), i.e., the atmospheric surface layer (SL), reflects the interactions of external forcing, land surface, vegetation, human influence and the atmosphere. Vertical profiles of atmospheric variables in the SL at high spatial (meters) and temporal (1 Hz and better) resolution increase our understanding of these interactions but are still challenging to measure appropriately. Traditional ground-based observations include towers that often cover only a few measurement heights at a fixed location. At the same time, most remote sensing techniques and aircraft measurements have limitations to achieve sufficient detail close to the ground (up to 50 m). Vertical and horizontal transects of the PBL can be complemented by unmanned aerial vehicles (UAV). Our aim in this case study is to assess the use of a multicopter-type UAV for the spatial sampling of air and simultaneously the sensing of meteorological variables for the study of the surface exchange processes. To this end, a UAV was equipped with onboard air temperature and humidity sensors, while wind conditions were determined from the UAV's flight control sensors. Further, the UAV was used to systematically change the location of a sample inlet connected to a sample tube, allowing the observation of methane abundance using a ground-based analyzer. Vertical methane gradients of about 0.3 ppm were found during stable atmospheric conditions. Our results showed that both methane and meteorological conditions were in agreement with other observations at the site during the ScaleX-2015 campaign. The multicopter-type UAV was capable of simultaneous in situ sensing of meteorological state variables and sampling of air up to 50 m above the surface, which extended the vertical profile height of existing tower-based infrastructure by a factor of 5.

  16. Service oriented architecture assessment based on software components

    Directory of Open Access Journals (Sweden)

    Mahnaz Amirpour

    2016-01-01

    Full Text Available Enterprise architecture, with detailed descriptions of the functions of information technology in the organization, tries to reduce the complexity of technology applications resulting in tools with greater efficiency in achieving the objectives of the organization. Enterprise architecture consists of a set of models describing this technology in different components performance as well as various aspects of the applications in any organization. Therefore, information technology development and maintenance management can perform well within organizations. This study aims to suggest a method to identify different types of services in service-oriented architecture analysis step that applies some previous approaches in an integrated form and, based on the principles of software engineering, to provide a simpler and more transparent approach through the expression of analysis details. Advantages and disadvantages of proposals should be evaluated before the implementation and costs allocation. Evaluation methods can better identify strengths and weaknesses of the current situation apart from selecting appropriate model out of several suggestions, and clarify this technology development solution for organizations in the future. We will be able to simulate data and processes flow within the organization by converting the output of the model to colored Petri nets and evaluate and test it by examining various inputs to enterprise architecture before implemented in terms of reliability and response time. A model of application has been studied for the proposed model and the results can describe and design architecture for data.

  17. Cnn Based Retinal Image Upscaling Using Zero Component Analysis

    Science.gov (United States)

    Nasonov, A.; Chesnakov, K.; Krylov, A.

    2017-05-01

    The aim of the paper is to obtain high quality of image upscaling for noisy images that are typical in medical image processing. A new training scenario for convolutional neural network based image upscaling method is proposed. Its main idea is a novel dataset preparation method for deep learning. The dataset contains pairs of noisy low-resolution images and corresponding noiseless highresolution images. To achieve better results at edges and textured areas, Zero Component Analysis is applied to these images. The upscaling results are compared with other state-of-the-art methods like DCCI, SI-3 and SRCNN on noisy medical ophthalmological images. Objective evaluation of the results confirms high quality of the proposed method. Visual analysis shows that fine details and structures like blood vessels are preserved, noise level is reduced and no artifacts or non-existing details are added. These properties are essential in retinal diagnosis establishment, so the proposed algorithm is recommended to be used in real medical applications.

  18. Internet MEMS design tools based on component technology

    Science.gov (United States)

    Brueck, Rainer; Schumer, Christian

    1999-03-01

    The micro electromechanical systems (MEMS) industry in Europe is characterized by small and medium sized enterprises specialized on products to solve problems in specific domains like medicine, automotive sensor technology, etc. In this field of business the technology driven design approach known from micro electronics is not appropriate. Instead each design problem aims at its own, specific technology to be used for the solution. The variety of technologies at hand, like Si-surface, Si-bulk, LIGA, laser, precision engineering requires a huge set of different design tools to be available. No single SME can afford to hold licenses for all these tools. This calls for a new and flexible way of designing, implementing and distributing design software. The Internet provides a flexible manner of offering software access along with methodologies of flexible licensing e.g. on a pay-per-use basis. New communication technologies like ADSL, TV cable of satellites as carriers promise to offer a bandwidth sufficient even for interactive tools with graphical interfaces in the near future. INTERLIDO is an experimental tool suite for process specification and layout verification for lithography based MEMS technologies to be accessed via the Internet. The first version provides a Java implementation even including a graphical editor for process specification. Currently, a new version is brought into operation that is based on JavaBeans component technology. JavaBeans offers the possibility to realize independent interactive design assistants, like a design rule checking assistants, a process consistency checking assistants, a technology definition assistants, a graphical editor assistants, etc. that may reside distributed over the Internet, communicating via Internet protocols. Each potential user thus is able to configure his own dedicated version of a design tool set dedicated to the requirements of the current problem to be solved.

  19. Component Based Development - Where is the Place for Formalism?

    DEFF Research Database (Denmark)

    Makowski, Piotr; Ravn, Anders Peter

    2003-01-01

    A software component has a contract that specifies its properties and thus define conditions for its use. The contract is an obvious object for formalization. It could assist in conformance checking for manufactured components and in checking consistent use of them in a concrete system. However, ...

  20. Speckle based configuration for simultaneous in vitro inspection of mechanical contractions of cardiac myocyte cells

    Science.gov (United States)

    Golberg, Mark; Fixler, Dror; Shainberg, Asher; Zlochiver, Sharon; Micó, Vicente; Garcia, Javier; Beiderman, Yevgeny; Zalevsky, Zeev

    2013-04-01

    In this manuscript we propose optical lensless configuration for a remote non-contact measuring of mechanical contractions of vast number of cardiac myocytes. All the myocytes were taken from rats, and the measurements were done in an in vitro mode. The optical method is based on temporal analysis of secondary reflected speckle patterns generated in lensless microscope configuration. The processing involves analyzing the movement and the change in the statistics of the generated secondary speckle patterns that are created on top of the cell culture when it is illuminated by a spot of laser beam. The main advantage of the proposed system is the ability to measure many cells simultaneously (approximately one thousand cells) and to extract the statistical data of their movement at once. The presented experimental results also include investigation the effect of isoproteranol on cells contraction process.

  1. Simultaneous measurement of CO2 sorption and swelling of phosphate-based ionic liquid

    Directory of Open Access Journals (Sweden)

    Junfeng Wang

    2016-10-01

    Full Text Available The development of alternative CO2 capture solvents such as ionic liquids (ILs and nanoparticle organic hybrid materials (NOHMs have provided interesting options for CO2 capture. In this study, CO2 interactions with 1,3-dimethylimidazolium dimethylphosphate ([MMIM]DMP, 1-ethyl-3-methylimidazolium dimethylphosphate ([EMIM]DMP and 1-ethyl-3-methylimidazolium diethylphosphate ([EMIM]DEP that contain inorganic ester groups based on phosphate, were investigated using ATR FT-IR spectroscopy. CO2-induced swelling, CO2 diffusivity and CO2 capture capacity were simultaneously measured to identify CO2 capture mechanisms, kinetics and diffusion behaviors as a function of the alkyl chain length of the cation. Henry's law constants of CO2 were found to be in the range of 4–11 MPa, which is in agreement with those reported in other studies. Keywords: CO2 capture, ATR FT-IR spectroscopy, Ionic liquids, Mechanism, Diffusivity

  2. Single SOA based simultaneous amplitude regeneration for WDM-PDM RZ-PSK signals.

    Science.gov (United States)

    Wu, Wenhan; Yu, Yu; Zou, Bingrong; Yang, Weili; Zhang, Xinliang

    2013-03-25

    We propose and demonstrate all-optical amplitude regeneration for the wavelength division multiplexing and polarization division multiplexing (WDM-PDM) return-to-zero phase shift keying (RZ-PSK) signals using a single semiconductor optical amplifier (SOA) and subsequent filtering. The regeneration is based on the cross phase modulation (XPM) effect in the saturated SOA and the subsequent narrow filtering. The spectrum of the distorted signal can be broadened due to the phase modulation induced by the synchronous optical clock signal. A narrow band pass filter is utilized to extract part of the broadened spectrum and remove the amplitude noise, while preserving the phase information. The working principle for multi-channel and polarization orthogonality preserving is analyzed. 4-channel dual polarization signals can be simultaneously amplitude regenerated without introducing wavelength and polarization demultiplexing. An average power penalty improvement of 1.75dB can be achieved for the WDM-PDM signals.

  3. Calibration and stability of a SiPM-based simultaneous PET/MR insert

    Energy Technology Data Exchange (ETDEWEB)

    Lerche, Christoph W., E-mail: christoph.lerche@philips.com [Philips Research, Europe, Eindhoven (Netherlands); Mackewn, Jane [Kings College London (United Kingdom); Goldschmidt, Benjamin [Philips Research, Europe, Eindhoven (Netherlands); RWTH University Aachen (Germany); Salomon, Andre; Gebbhardt, Pierre; Weissler, Bjoern; Ayres, Richard [Philips Research, Europe Eindhoven (Netherlands); Kings College London (United Kingdom); Marsden, Paul [Kings College London (United Kingdom); Schulz, Volkmar [Philips Research, Europe, Eindhoven (Netherlands); RWTH University Aachen (Germany)

    2013-02-21

    On behalf of the HYPER Image project, a Silicon photomultiplier (SiPM) based preclinical PET insert for a commercial human 3 T MRI scanner was built. In this contribution we report on the stability of imaging performance of the PET scanner and MR hardness and compatibility. From data sets that were acquired during the last 7 months we extracted SiPM gain values and their annual drift, the mean energy resolution and the energy resolution drift, spatial resolution and spatial resolution drift, and photo peak position and their annual drift. Further, a point source and a hot rod phantom was imaged fully simultaneously with the MRI scanner and the PET scanner. No interference between either modality was observed.

  4. The global classroom model simultaneous campus- and home-based education using videoconferencing

    DEFF Research Database (Denmark)

    Weitze, Charlotte Lærke; Ørngreen, Rikke

    2014-01-01

    This paper presents and discusses findings about how students, teachers, and the organization experience a start-up-project applying videoconferences between campus and home. This is new territory for adult learning centers. The research is based on the Global Classroom Model as it is implemented...... are present on campus in the classroom, while other students are participating simultaneously from their home using laptops. In this paper, the case and context of VUC Storstrøm, the research design chosen, and the literature that already exists in this area constitutes the backdrop for the analysis...... experiences and on the organizational issues related to the transition to the Global Classroom Model as well as provide outlines to the consequences these findings may have, for example in relation to the continued development of the teachers' educational designs....

  5. Applying and Individual-Based Model to Simultaneously Evaluate Net Ecosystem Production and Tree Diameter Increment

    Science.gov (United States)

    Fang, F. J.

    2017-12-01

    Reconciling observations at fundamentally different scales is central in understanding the global carbon cycle. This study investigates a model-based melding of forest inventory data, remote-sensing data and micrometeorological-station data ("flux towers" estimating forest heat, CO2 and H2O fluxes). The individual tree-based model FORCCHN was used to evaluate the tree DBH increment and forest carbon fluxes. These are the first simultaneous simulations of the forest carbon budgets from flux towers and individual-tree growth estimates of forest carbon budgets using the continuous forest inventory data — under circumstances in which both predictions can be tested. Along with the global implications of such findings, this also improves the capacity for forest sustainable management and the comprehensive understanding of forest ecosystems. In forest ecology, diameter at breast height (DBH) of a tree significantly determines an individual tree's cross-sectional sapwood area, its biomass and carbon storage. Evaluation the annual DBH increment (ΔDBH) of an individual tree is central to understanding tree growth and forest ecology. Ecosystem Carbon flux is a consequence of key ecosystem processes in the forest-ecosystem carbon cycle, Gross and Net Primary Production (GPP and NPP, respectively) and Net Ecosystem Respiration (NEP). All of these closely relate with tree DBH changes and tree death. Despite advances in evaluating forest carbon fluxes with flux towers and forest inventories for individual tree ΔDBH, few current ecological models can simultaneously quantify and predict the tree ΔDBH and forest carbon flux.

  6. SPARSE: quadratic time simultaneous alignment and folding of RNAs without sequence-based heuristics.

    Science.gov (United States)

    Will, Sebastian; Otto, Christina; Miladi, Milad; Möhl, Mathias; Backofen, Rolf

    2015-08-01

    RNA-Seq experiments have revealed a multitude of novel ncRNAs. The gold standard for their analysis based on simultaneous alignment and folding suffers from extreme time complexity of [Formula: see text]. Subsequently, numerous faster 'Sankoff-style' approaches have been suggested. Commonly, the performance of such methods relies on sequence-based heuristics that restrict the search space to optimal or near-optimal sequence alignments; however, the accuracy of sequence-based methods breaks down for RNAs with sequence identities below 60%. Alignment approaches like LocARNA that do not require sequence-based heuristics, have been limited to high complexity ([Formula: see text] quartic time). Breaking this barrier, we introduce the novel Sankoff-style algorithm 'sparsified prediction and alignment of RNAs based on their structure ensembles (SPARSE)', which runs in quadratic time without sequence-based heuristics. To achieve this low complexity, on par with sequence alignment algorithms, SPARSE features strong sparsification based on structural properties of the RNA ensembles. Following PMcomp, SPARSE gains further speed-up from lightweight energy computation. Although all existing lightweight Sankoff-style methods restrict Sankoff's original model by disallowing loop deletions and insertions, SPARSE transfers the Sankoff algorithm to the lightweight energy model completely for the first time. Compared with LocARNA, SPARSE achieves similar alignment and better folding quality in significantly less time (speedup: 3.7). At similar run-time, it aligns low sequence identity instances substantially more accurate than RAF, which uses sequence-based heuristics. © The Author 2015. Published by Oxford University Press.

  7. Multistage principal component analysis based method for abdominal ECG decomposition.

    Science.gov (United States)

    Petrolis, Robertas; Gintautas, Vladas; Krisciukaitis, Algimantas

    2015-02-01

    Reflection of fetal heart electrical activity is present in registered abdominal ECG signals. However this signal component has noticeably less energy than concurrent signals, especially maternal ECG. Therefore traditionally recommended independent component analysis, fails to separate these two ECG signals. Multistage principal component analysis (PCA) is proposed for step-by-step extraction of abdominal ECG signal components. Truncated representation and subsequent subtraction of cardio cycles of maternal ECG are the first steps. The energy of fetal ECG component then becomes comparable or even exceeds energy of other components in the remaining signal. Second stage PCA concentrates energy of the sought signal in one principal component assuring its maximal amplitude regardless to the orientation of the fetus in multilead recordings. Third stage PCA is performed on signal excerpts representing detected fetal heart beats in aim to perform their truncated representation reconstructing their shape for further analysis. The algorithm was tested with PhysioNet Challenge 2013 signals and signals recorded in the Department of Obstetrics and Gynecology, Lithuanian University of Health Sciences. Results of our method in PhysioNet Challenge 2013 on open data set were: average score: 341.503 bpm(2) and 32.81 ms.

  8. A Robust MEMS Based Multi-Component Sensor for 3D Borehole Seismic Arrays

    Energy Technology Data Exchange (ETDEWEB)

    Paulsson Geophysical Services

    2008-03-31

    The objective of this project was to develop, prototype and test a robust multi-component sensor that combines both Fiber Optic and MEMS technology for use in a borehole seismic array. The use such FOMEMS based sensors allows a dramatic increase in the number of sensors that can be deployed simultaneously in a borehole seismic array. Therefore, denser sampling of the seismic wave field can be afforded, which in turn allows us to efficiently and adequately sample P-wave as well as S-wave for high-resolution imaging purposes. Design, packaging and integration of the multi-component sensors and deployment system will target maximum operating temperature of 350-400 F and a maximum pressure of 15000-25000 psi, thus allowing operation under conditions encountered in deep gas reservoirs. This project aimed at using existing pieces of deployment technology as well as MEMS and fiber-optic technology. A sensor design and analysis study has been carried out and a laboratory prototype of an interrogator for a robust borehole seismic array system has been assembled and validated.

  9. Design and Fabrication of SOI-based photonic crystal components

    DEFF Research Database (Denmark)

    Borel, Peter Ingo; Frandsen, Lars Hagedorn; Harpøth, Anders

    2004-01-01

    We present examples of ultra-compact photonic crystal components realized in silicon-on-insulator material. We have fabricated several different types of photonic crystal waveguide components displaying high transmission features. This includes 60° and 120° bends, different types of couplers......, and splitters. Recently, we have designed and fabricated components with more than 200 nm bandwidths. Design strategies to enhance the performance include systematic variation of design parameters using finite-difference time-domain simulations and inverse design methods such as topology optimization....

  10. Analysis of a micropolarizer array-based simultaneous phase-shifting interferometer.

    Science.gov (United States)

    Novak, Matt; Millerd, James; Brock, Neal; North-Morris, Michael; Hayes, John; Wyant, James

    2005-11-10

    Recent technological innovations have enabled the development of a new class of dynamic (vibration-insensitive) interferometer based on a CCD pixel-level phase-shifting approach. We present theoretical and experimental results for an interferometer based on this pixelated phase-shifting technique. Analyses of component errors and instrument functionality are presented. We show that the majority of error sources cause relatively small magnitude peak-to-valley errors in measurement of the order of 0.002-0.005lambda. These errors are largely mitigated by high-rate data acquisition and consequent data averaging.

  11. Simultaneous Determination of Seven Components in Rat Plasma by the UPLC-MS/MS Method and Application of Pharmacokinetic Studies to SimiaoYong’an Decoction

    Directory of Open Access Journals (Sweden)

    Yuanyan Liu

    2017-11-01

    Full Text Available SimiaoYong’an Decoction (SYD is a classical traditional Chinese prescription that is used for the treatment of gangrene, heat-clearing, detoxification and pain alleviation. We developed a sensitive ultra-performance liquid chromatography-tandem mass spectrum (UPLC-MS/MS method for the simultaneous determination of seven major active ingredients of SYD extract (i.e., harpagide, chlorogenic acid, sweroside, loganin, liquiritin, angoroside C and harpagoside in rat plasma. The preliminary steps in the plasma analysis were the addition of an internal standard such as linarin, followed by protein precipitation with methanol. Separation of the active ingredients was performed on an ACQUITY UPLC® BEH C18 column (100 mm × 2.1 mm, 1.7 μm at a flow rate of 0.2 mL/min with methanol/water 0.1% formic acid aqueous (V/V as the mobile phase. Detection was performed on a triple quadrupole tandem MS (QqQ-MS via negative ion electrospray ionization in multiple reactions monitoring (MRM mode. All calibration curves showed good linearity (r > 0.99 over the concentration range with a low limit of quantification between 0.029 and 5.813 ng/mL. Precision was evaluated by intra-day and inter-day assays, and the percentages of the RSD were all within 8.1%. The extraction efficiency and matrix effect were 80.6–113.6% and 82.9–99.5%, respectively. The validated method was successfully applied to a pharmacokinetic study in rats after oral administration of SYD extract and the corresponding single and combined traditional Chinese medicines (TCMs. The pharmacokinetic properties of the seven ingredients showed dynamic changes due to counteraction among the different coexisting components. The established approach has proven useful in the study of the active constituents in a traditional Chinese prescription.

  12. Simultaneous Determination of Multiple Components in Guanjiekang in Rat Plasma via the UPLC–MS/MS Method and Its Application in Pharmacokinetic Study

    Directory of Open Access Journals (Sweden)

    Jian Wu

    2016-12-01

    Full Text Available Guanjiekang (GJK that is formed by five medicinal herbs including Astragali Radix, Aconiti Lateralis Radix Praeparaia, Glycyrrhizae Radix et Rhizoma, Corydalis Rhizoma and Paeoniae Radix Alba was used for the treatment of rheumatoid arthritis (RA. However, the pharmacokinetic (PK profile of active components in GJK remains unclear. This study aims to evaluate the pharmacokinetic behavior of seven representative active constituents in GJK (i.e., benzoylhypaconine, benzoylmesaconine, paeoniflorin, tetrahydropalmatine, calycosin-7-glucoside, formononetin and isoliquiritigenin after oral administration of GJK in rats. A rapid, sensitive and reliable ultra-performance liquid chromatography-tandem mass spectrometer (UPLC–MS/MS method has been successfully developed for the simultaneous determination of these seven constituents in rat plasma. Chromatographic separation was achieved on a C18 column with a gradient elution program that consists of acetonitrile and water (containing 0.1% formic acid at a flow rate of 0.35 mL/min. Detection was performed under the multiple reaction monitoring (MRM in the positive electrospray ionization (ESI mode. The calibration curves exhibited good linearity (R2 > 0.99 over a wide concentration range for all constituents. The accuracies ranged from 92.9% to 107.8%, and the intra-day and inter-day precisions at three different levels were below 15%. Our PK results showed that these seven compounds were quickly absorbed after the administration of the GJK product, and Tmax ranged from 30 min to 189 min. The in vivo concentrations of paeoniflorin and isoliquiritigenin were significantly higher than the reported in vitro effective doses, indicating that they could partly contribute to the therapeutic effect of GJK. Therefore, we conclude that pharmacokinetic studies of representative bioactive chemicals after administration of complex herbal products are not only necessary but also feasible. Moreover, these seven

  13. Evaluation of the PET component of simultaneous [18F]choline PET/MRI in prostate cancer: comparison with [18F]choline PET/CT

    International Nuclear Information System (INIS)

    Wetter, Axel; Lipponer, Christine; Nensa, Felix; Altenbernd, Jens-Christian; Schlosser, Thomas; Lauenstein, Thomas; Heusch, Philipp; Ruebben, Herbert; Bockisch, Andreas; Poeppel, Thorsten; Nagarajah, James

    2014-01-01

    The aim of this study was to evaluate the positron emission tomography (PET) component of [ 18 F]choline PET/MRI and compare it with the PET component of [ 18 F]choline PET/CT in patients with histologically proven prostate cancer and suspected recurrent prostate cancer. Thirty-six patients were examined with simultaneous [ 18 F]choline PET/MRI following combined [ 18 F]choline PET/CT. Fifty-eight PET-positive lesions in PET/CT and PET/MRI were evaluated by measuring the maximum and mean standardized uptake values (SUV max and SUV mean ) using volume of interest (VOI) analysis. A scoring system was applied to determine the quality of the PET images of both PET/CT and PET/MRI. Agreement between PET/CT and PET/MRI regarding SUV max and SUV mean was tested using Pearson's product-moment correlation and Bland-Altman analysis. All PET-positive lesions that were visible on PET/CT were also detectable on PET/MRI. The quality of the PET images was comparable in both groups. Median SUV max and SUV mean of all lesions were significantly lower in PET/MRI than in PET/CT (5.2 vs 6.1, p max of PET/CT and PET/MRI (R = 0.86, p mean of PET/CT and PET/MRI (R = 0.81, p max of PET/CT vs PET/MRI and -1.12 to +2.23 between SUV mean of PET/CT vs PET/MRI. PET image quality of PET/MRI was comparable to that of PET/CT. A highly significant correlation between SUV max and SUV mean was found. Both SUV max and SUV mean were significantly lower in [ 18 F]choline PET/MRI than in [ 18 F]choline PET/CT. Differences of SUV max and SUV mean might be caused by different techniques of attenuation correction. Furthermore, differences in biodistribution and biokinetics of [ 18 F]choline between the subsequent examinations and in the respective organ systems have to be taken into account. (orig.)

  14. Magnetotail magnetic flux monitoring based on simultaneous solar wind and magnetotail observations

    Science.gov (United States)

    Shukhtina, M. A.; Gordeev, E. I.; Sergeev, V. A.; Tsyganenko, N. A.; Clausen, L. B. N.; Milan, S. E.

    2016-09-01

    The magnetotail magnetic flux (MTF) is an important global variable to describe the magnetospheric state and dynamics. Existing methods of MTF estimation on the basis of the polar cap area, inferred from observations of global auroras and field-aligned currents, do not allow benchmarking due to the absence of a gauge for comparison; besides, they rarely allow a systematic nearly real time MTF monitoring. We describe three modifications (F0, F1, and F2) of the method to calculate the MTF, based on simultaneous spacecraft observations in the magnetotail and in the solar wind, suitable for real-time MTF monitoring. The MTF dependence on the solar wind parameters and the observed tail lobe magnetic field is derived from the pressure balance conditions. An essential part of this study is the calibration of our approximate method against global 3-D MHD simulations and the empirical T14 magnetospheric field model. The calibration procedure provides all variables required to evaluate F0, F1, and F2 quantities and, at the same time, computes the reference MTF value through any tail cross section. It allowed us to extend the method to be used in the near tail, investigate its errors, and define the applicability domain. The method was applied to Cluster and THEMIS measurements and compared with methods of polar cap area calculation based on IMAGE and AMPERE observations. We also discuss possible applications and some recent results based on the proposed method.

  15. Invisible Base Electrode Coordinates Approximation for Simultaneous SPECT and EEG Data Visualization

    Directory of Open Access Journals (Sweden)

    Kowalczyk L.

    2014-04-01

    Full Text Available This work was performed as part of a larger research concerning the feasibility of improving the localization of epileptic foci, as compared to the standard SPECT examination, by applying the technique of EEG mapping. The presented study extends our previous work on the development of a method for superposition of SPECT images and EEG 3D maps when these two examinations are performed simultaneously. Due to the lack of anatomical data in SPECT images it is a much more difficult task than in the case of MRI/EEG study where electrodes are visible in morphological images. Using the appropriate dose of radioisotope we mark five base electrodes to make them visible in the SPECT image and then approximate the coordinates of the remaining electrodes using properties of the 10-20 electrode placement system and the proposed nine-ellipses model. This allows computing a sequence of 3D EEG maps spanning on all electrodes. It happens, however, that not all five base electrodes can be reliably identified in SPECT data. The aim of the current study was to develop a method for determining the coordinates of base electrode(s missing in the SPECT image. The algorithm for coordinates approximation has been developed and was tested on data collected for three subjects with all visible electrodes. To increase the accuracy of the approximation we used head surface models. Freely available model from Oostenveld research based on data from SPM package and our own model based on data from our EEG/SPECT studies were used. For data collected in four cases with one electrode not visible we compared the invisible base electrode coordinates approximation for Oostenveld and our models. The results vary depending on the missing electrode placement, but application of the realistic head model significantly increases the accuracy of the approximation.

  16. A combined Component-Based Approach for the Design of Distributed Software Systems

    NARCIS (Netherlands)

    Guareis de farias, Cléver; Ferreira Pires, Luis; van Sinderen, Marten J.; Quartel, Dick; Yang, H.; Gupta, S.

    2001-01-01

    Component-based software development enables the construction of software artefacts by assembling binary units of production, distribution and deployment, the so-called components. Several approaches to component-based development have been proposed recently. Most of these approaches are based on

  17. Simultaneous quantitative live cell imaging of multiple FRET-based biosensors.

    Science.gov (United States)

    Woehler, Andrew

    2013-01-01

    We have developed a novel method for multi-color spectral FRET analysis which is used to study a system of three independent FRET-based molecular sensors composed of the combinations of only three fluorescent proteins. This method is made possible by a novel routine for computing the 3-D excitation/emission spectral fingerprint of FRET from reference measurements of the donor and acceptor alone. By unmixing the 3D spectrum of the FRET sample, the total relative concentrations of the fluorophores and their scaled FRET efficiencies are directly measured, from which apparent FRET efficiencies can be computed. If the FRET sample is composed of intramolecular FRET sensors it is possible to determine the total relative concentration of the sensors and then estimate absolute FRET efficiency of each sensor. Using multiple tandem constructs with fixed FRET efficiency as well as FRET-based calcium sensors with novel fluorescent protein combinations we demonstrate that the computed FRET efficiencies are accurate and changes in these quantities occur without crosstalk. We provide an example of this method's potential by demonstrating simultaneous imaging of spatially colocalized changes in [Ca(2+)], [cAMP], and PKA activity.

  18. Simultaneous quantitative live cell imaging of multiple FRET-based biosensors.

    Directory of Open Access Journals (Sweden)

    Andrew Woehler

    Full Text Available We have developed a novel method for multi-color spectral FRET analysis which is used to study a system of three independent FRET-based molecular sensors composed of the combinations of only three fluorescent proteins. This method is made possible by a novel routine for computing the 3-D excitation/emission spectral fingerprint of FRET from reference measurements of the donor and acceptor alone. By unmixing the 3D spectrum of the FRET sample, the total relative concentrations of the fluorophores and their scaled FRET efficiencies are directly measured, from which apparent FRET efficiencies can be computed. If the FRET sample is composed of intramolecular FRET sensors it is possible to determine the total relative concentration of the sensors and then estimate absolute FRET efficiency of each sensor. Using multiple tandem constructs with fixed FRET efficiency as well as FRET-based calcium sensors with novel fluorescent protein combinations we demonstrate that the computed FRET efficiencies are accurate and changes in these quantities occur without crosstalk. We provide an example of this method's potential by demonstrating simultaneous imaging of spatially colocalized changes in [Ca(2+], [cAMP], and PKA activity.

  19. A Game-Based Virtualized Reality Approach for Simultaneous Rehabilitation of Motor Skill and Confidence

    Directory of Open Access Journals (Sweden)

    Alasdair G. Thin

    2012-01-01

    Full Text Available Virtualized reality games offer highly interactive and engaging user experience and therefore game-based approaches (GBVR may have significant potential to enhance clinical rehabilitation practice as traditional therapeutic exercises are often repetitive and boring, reducing patient compliance. The aim of this study was to investigate if a rehabilitation training programme using GBVR could simultaneously improve both motor skill (MS and confidence (CON, as they are both important determinants of daily living and physical and social functioning. The study was performed using a nondominant hand motor deficit model in nonambidextrous healthy young adults, whereby dominant and nondominant arms acted as control and intervention conditions, respectively. GBVR training was performed using a commercially available tennis-based game. CON and MS were assessed by having each subject perform a comparable real-world motor task (RWMT before and after training. Baseline CON and MS for performing the RWMT were significantly lower for the nondominant hand and improved after GBVR training, whereas there were no changes in the dominant (control arm. These results demonstrate that by using a GBVR approach to address a MS deficit in a real-world task, improvements in both MS and CON can be facilitated and such approaches may help increase patient compliance.

  20. Simultaneous determination of five Alternaria toxins in cereals using QuEChERS-based methodology.

    Science.gov (United States)

    Zhou, Jian; Xu, Jiao-Jiao; Cai, Zeng-Xuan; Huang, Bai-Fen; Jin, Mi-Cong; Ren, Yi-Ping

    2017-11-15

    Two analytical approaches, including ultra-high performance liquid chromatograph linked with photo-diode array/fluorescence detector, and ultra-high performance liquid chromatography-tandem mass spectrometry, have been proposed for simultaneous determination of five Alternaria toxins in cereals, which both based on QuEChERS strategy. After QuEChERS extraction and salting out, the collected supernatant was subjected to an extra dispersive liquid-liquid microextraction step prior to quantitative analysis. Response surface methodology based on central composite design was employed to optimize the micro-extraction conditions. During photo-diode array/fluorescence detector method validation, satisfactory analytical characteristics, in terms of selectivity, recovery (72.7%-109.1%), precision (inter-day RSDs <9.6%), sensitivity (limits of quantification ranged from 2.1μgkg -1 to 120.0μgkg -1 ) and linearity (R 2 all higher than 0.9984), were achieved. Mass spectrometry method was employed as a certified method for accuracy. The two methodologies were successfully applied to 71 samples including three different matrices and the quantitative results were compared. As the result of non-parametric test shown, the established two analytical approach exhibited comparable quantitative accuracy to each other. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Ionic liquids based simultaneous ultrasonic and microwave assisted extraction of phenolic compounds from burdock leaves

    International Nuclear Information System (INIS)

    Lou Zaixiang; Wang Hongxin; Zhu Song; Chen Shangwei; Zhang Ming; Wang Zhouping

    2012-01-01

    The ionic liquids based simultaneous ultrasonic and microwave assisted extraction (IL-UMAE) technique was first proposed and applied to isolate compounds. The ionic liquids comprising a range of four anions, five 1-alkyl-3-methylimidazolium derivatives were designed and prepared. The results suggested that varying the anion and cation both had apparent effects on the extraction of phenolics. The results also showed that irradiation power, time and solid–liquid ratio significantly affected the yields. The yields of caffeic acid and quercetin obtained by IL-UMAE were higher than those by regular UMAE. Compared with conventional heat-reflux extraction (HRE), the proposed approach exhibited higher efficiency (8–17% enhanced) and shorter extraction time (from 5 h to 30 s). The results indicated ILUMAE to be a fast and efficient extraction technique. Moreover, the proposed method was validated by the reproducibility and recovery experiments. The ILUMAE method provided good recoveries (from 96.1% to 105.3%) with RSD lower than 5.2%, which indicated that the proposed method was credible. Based on the designable nature of ionic liquids, and the rapid and highly efficient performance of the proposed approach, ILUMAE provided a new alternative for preparation of various useful substances from solid samples.

  2. Simultaneous Wireless Information and Power Transfer for MIMO Interference Channel Networks Based on Interference Alignment

    Directory of Open Access Journals (Sweden)

    Anming Dong

    2017-09-01

    Full Text Available This paper considers power splitting (PS-based simultaneous wireless information and power transfer (SWIPT for multiple-input multiple-output (MIMO interference channel networks where multiple transceiver pairs share the same frequency spectrum. As the PS model is adopted, an individual receiver splits the received signal into two parts for information decoding (ID and energy harvesting (EH, respectively. Aiming to minimize the total transmit power, transmit precoders, receive filters and PS ratios are jointly designed under a predefined signal-to-interference-plus-noise ratio (SINR and EH constraints. The formulated joint transceiver design and power splitting problem is non-convex and thus difficult to solve directly. In order to effectively obtain its solution, the feasibility conditions of the formulated non-convex problem are first analyzed. Based on the analysis, an iterative algorithm is proposed by alternatively optimizing the transmitters together with the power splitting factors and the receivers based on semidefinite programming (SDP relaxation. Moreover, considering the prohibitive computational cost of the SDP for practical applications, a low-complexity suboptimal scheme is proposed by separately designing interference-suppressing transceivers based on interference alignment (IA and optimizing the transmit power allocation together with splitting factors. The transmit power allocation and receive power splitting problem is then recast as a convex optimization problem and solved efficiently. To further reduce the computational complexity, a low-complexity scheme is proposed by calculating the transmit power allocation and receive PS ratios in closed-form. Simulation results show the effectiveness of the proposed schemes in achieving SWIPT for MIMO interference channel (IC networks.

  3. Life Assessment of Steam Turbine Components Based on Viscoplastic Analysis

    Science.gov (United States)

    Choi, Woo-Sung; Fleury, Eric; Kim, Bum-Shin; Hyun, Jung-Seob

    Unsteady thermal and mechanical loading in turbine components is caused due to the transient regimes arising during start-ups and shut-downs and due to changes in the operating regime in steam power plants; this results in nonuniform strain and stress distribution. Thus, an accurate knowledge of the stresses caused by various loading conditions is required to ensure the integrity and to ensure an accurate life assessment of the components of a turbine. Although the materials of the components of the steam turbine deform inelastically at a high temperature, currently, only elastic calculations are performed for safety and simplicity. Numerous models have been proposed to describe the viscoplastic (time-dependent) behavior; these models are rather elaborate and it is difficult to incorporate them into a finite element code in order to simulate the loading of complex structures. In this paper, the total lifetime of the components of a steam turbine was calculated by combining the viscoplastic constitutive equation with the ABAQUS finite element code. Viscoplastic analysis was conducted by focusing mainly on simplified constitutive equations with linear kinematic hardening, which is simple enough to be used effectively in computer simulation. The von Mises stress distribution of an HIP turbine rotor was calculated during the cold start-up operation of the rotor, and a reasonable number of cycles were obtained from the equation of Langer.

  4. High Accuracy Passive Magnetic Field-Based Localization for Feedback Control Using Principal Component Analysis

    Directory of Open Access Journals (Sweden)

    Shaohui Foong

    2016-08-01

    Full Text Available In this paper, a novel magnetic field-based sensing system employing statistically optimized concurrent multiple sensor outputs for precise field-position association and localization is presented. This method capitalizes on the independence between simultaneous spatial field measurements at multiple locations to induce unique correspondences between field and position. This single-source-multi-sensor configuration is able to achieve accurate and precise localization and tracking of translational motion without contact over large travel distances for feedback control. Principal component analysis (PCA is used as a pseudo-linear filter to optimally reduce the dimensions of the multi-sensor output space for computationally efficient field-position mapping with artificial neural networks (ANNs. Numerical simulations are employed to investigate the effects of geometric parameters and Gaussian noise corruption on PCA assisted ANN mapping performance. Using a 9-sensor network, the sensing accuracy and closed-loop tracking performance of the proposed optimal field-based sensing system is experimentally evaluated on a linear actuator with a significantly more expensive optical encoder as a comparison.

  5. A Robust Approach for a Filter-Based Monocular Simultaneous Localization and Mapping (SLAM System

    Directory of Open Access Journals (Sweden)

    Antoni Grau

    2013-07-01

    Full Text Available Simultaneous localization and mapping (SLAM is an important problem to solve in robotics theory in order to build truly autonomous mobile robots. This work presents a novel method for implementing a SLAM system based on a single camera sensor. The SLAM with a single camera, or monocular SLAM, is probably one of the most complex SLAM variants. In this case, a single camera, which is freely moving through its environment, represents the sole sensor input to the system. The sensors have a large impact on the algorithm used for SLAM. Cameras are used more frequently, because they provide a lot of information and are well adapted for embedded systems: they are light, cheap and power-saving. Nevertheless, and unlike range sensors, which provide range and angular information, a camera is a projective sensor providing only angular measurements of image features. Therefore, depth information (range cannot be obtained in a single step. In this case, special techniques for feature system-initialization are needed in order to enable the use of angular sensors (as cameras in SLAM systems. The main contribution of this work is to present a novel and robust scheme for incorporating and measuring visual features in filtering-based monocular SLAM systems. The proposed method is based in a two-step technique, which is intended to exploit all the information available in angular measurements. Unlike previous schemes, the values of parameters used by the initialization technique are derived directly from the sensor characteristics, thus simplifying the tuning of the system. The experimental results show that the proposed method surpasses the performance of previous schemes.

  6. A robust approach for a filter-based monocular simultaneous localization and mapping (SLAM) system.

    Science.gov (United States)

    Munguía, Rodrigo; Castillo-Toledo, Bernardino; Grau, Antoni

    2013-07-03

    Simultaneous localization and mapping (SLAM) is an important problem to solve in robotics theory in order to build truly autonomous mobile robots. This work presents a novel method for implementing a SLAM system based on a single camera sensor. The SLAM with a single camera, or monocular SLAM, is probably one of the most complex SLAM variants. In this case, a single camera, which is freely moving through its environment, represents the sole sensor input to the system. The sensors have a large impact on the algorithm used for SLAM. Cameras are used more frequently, because they provide a lot of information and are well adapted for embedded systems: they are light, cheap and power-saving. Nevertheless, and unlike range sensors, which provide range and angular information, a camera is a projective sensor providing only angular measurements of image features. Therefore, depth information (range) cannot be obtained in a single step. In this case, special techniques for feature system-initialization are needed in order to enable the use of angular sensors (as cameras) in SLAM systems. The main contribution of this work is to present a novel and robust scheme for incorporating and measuring visual features in filtering-based monocular SLAM systems. The proposed method is based in a two-step technique, which is intended to exploit all the information available in angular measurements. Unlike previous schemes, the values of parameters used by the initialization technique are derived directly from the sensor characteristics, thus simplifying the tuning of the system. The experimental results show that the proposed method surpasses the performance of previous schemes.

  7. A Framework for Final Drive Simultaneous Failure Diagnosis Based on Fuzzy Entropy and Sparse Bayesian Extreme Learning Machine

    Directory of Open Access Journals (Sweden)

    Qing Ye

    2015-01-01

    Full Text Available This research proposes a novel framework of final drive simultaneous failure diagnosis containing feature extraction, training paired diagnostic models, generating decision threshold, and recognizing simultaneous failure modes. In feature extraction module, adopt wavelet package transform and fuzzy entropy to reduce noise interference and extract representative features of failure mode. Use single failure sample to construct probability classifiers based on paired sparse Bayesian extreme learning machine which is trained only by single failure modes and have high generalization and sparsity of sparse Bayesian learning approach. To generate optimal decision threshold which can convert probability output obtained from classifiers into final simultaneous failure modes, this research proposes using samples containing both single and simultaneous failure modes and Grid search method which is superior to traditional techniques in global optimization. Compared with other frequently used diagnostic approaches based on support vector machine and probability neural networks, experiment results based on F1-measure value verify that the diagnostic accuracy and efficiency of the proposed framework which are crucial for simultaneous failure diagnosis are superior to the existing approach.

  8. Aptamer/quantum dot-based simultaneous electrochemical detection of multiple small molecules

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Haixia [Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715 (China); Jiang Bingying [School of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 400040 (China); Xiang Yun, E-mail: yunatswu@swu.edu.cn [Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715 (China); Zhang Yuyong; Chai Yaqin [Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715 (China); Yuan Ruo, E-mail: yuanruo@swu.edu.cn [Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715 (China)

    2011-03-04

    A novel strategy for 'signal on' and sensitive one-spot simultaneous detection of multiple small molecular analytes based on electrochemically encoded barcode quantum dot (QD) tags is described. The target analytes, adenosine triphosphate (ATP) and cocaine, respectively, are sandwiched between the corresponding set of surface-immobilized primary binding aptamers and the secondary binding aptamer/QD bioconjugates. The captured QDs yield distinct electrochemical signatures after acid dissolution, whose position and size reflect the identity and level, respectively, of the corresponding target analytes. Due to the inherent amplification feature of the QD labels and the 'signal on' detection scheme, as well as the sensitive monitoring of the metal ions released upon acid dissolution of the QD labels, low detection limits of 30 nM and 50 nM were obtained for ATP and cocaine, respectively, in our assays. Our multi-analyte sensing system also shows high specificity to target analytes and promising applicability to complex sample matrix, which makes the proposed assay protocol an attractive route for screening of small molecules in clinical diagnosis.

  9. Mathematical Modeling and Simulation of SWRO Process Based on Simultaneous Method

    Directory of Open Access Journals (Sweden)

    Aipeng Jiang

    2014-01-01

    Full Text Available Reverse osmosis (RO technique is one of the most efficient ways for seawater desalination to solve the shortage of freshwater. For prediction and analysis of the performance of seawater reverse osmosis (SWRO process, an accurate and detailed model based on the solution-diffusion and mass transfer theory is established. Since the accurate formulation of the model includes many differential equations and strong nonlinear equations (differential and algebraic equations, DAEs, to solve the problem efficiently, the simultaneous method through orthogonal collocation on finite elements and large scale solver were used to obtain the solutions. The model was fully discretized into NLP (nonlinear programming with large scale variables and equations, and then the NLP was solved by large scale solver of IPOPT. Validation of the formulated model and solution method is verified by case study on a SWRO plant. Then simulation and analysis are carried out to demonstrate the performance of reverse osmosis process; operational conditions such as feed pressure and feed flow rate as well as feed temperature are also analyzed. This work is of significant meaning for the detailed understanding of RO process and future energy saving through operational optimization.

  10. Simultaneous Channel and Feature Selection of Fused EEG Features Based on Sparse Group Lasso

    Directory of Open Access Journals (Sweden)

    Jin-Jia Wang

    2015-01-01

    Full Text Available Feature extraction and classification of EEG signals are core parts of brain computer interfaces (BCIs. Due to the high dimension of the EEG feature vector, an effective feature selection algorithm has become an integral part of research studies. In this paper, we present a new method based on a wrapped Sparse Group Lasso for channel and feature selection of fused EEG signals. The high-dimensional fused features are firstly obtained, which include the power spectrum, time-domain statistics, AR model, and the wavelet coefficient features extracted from the preprocessed EEG signals. The wrapped channel and feature selection method is then applied, which uses the logistical regression model with Sparse Group Lasso penalized function. The model is fitted on the training data, and parameter estimation is obtained by modified blockwise coordinate descent and coordinate gradient descent method. The best parameters and feature subset are selected by using a 10-fold cross-validation. Finally, the test data is classified using the trained model. Compared with existing channel and feature selection methods, results show that the proposed method is more suitable, more stable, and faster for high-dimensional feature fusion. It can simultaneously achieve channel and feature selection with a lower error rate. The test accuracy on the data used from international BCI Competition IV reached 84.72%.

  11. Verifying Embedded Systems using Component-based Runtime Observers

    DEFF Research Database (Denmark)

    Guan, Wei; Marian, Nicolae; Angelov, Christo K.

    Formal verification methods, such as exhaustive model checking, are often infeasible because of high computational complexity. Runtime observers (monitors) provide an alternative, light-weight verification method, which offers a non-exhaustive yet feasible approach to monitoring system behavior...... is a reconfigurable component processing a data structure, representing the state transition diagram of a non-deterministic state machine, i.e. a Buchi automaton derived from a system property specified in Linear Temporal Logic (LTL). Observer components have been implemented using design models and design patterns...... specified properties via simulation. The presented method has been experimentally validated in an industrial case study---a control system for a safety-critical medical ventilator unit....

  12. A two-component NZRI metamaterial based rectangular cloak

    Directory of Open Access Journals (Sweden)

    Sikder Sunbeam Islam

    2015-10-01

    Full Text Available A new two-component, near zero refractive index (NZRI metamaterial is presented for electromagnetic rectangular cloaking operation in the microwave range. In the basic design a pi-shaped, metamaterial was developed and its characteristics were investigated for the two major axes (x and z-axis wave propagation through the material. For the z-axis wave propagation, it shows more than 2 GHz bandwidth and for the x-axis wave propagation; it exhibits more than 1 GHz bandwidth of NZRI property. The metamaterial was then utilized in designing a rectangular cloak where a metal cylinder was cloaked perfectly in the C-band area of microwave regime. The experimental result was provided for the metamaterial and the cloak and these results were compared with the simulated results. This is a novel and promising design for its two-component NZRI characteristics and rectangular cloaking operation in the electromagnetic paradigm.

  13. A Component-based Programming Model for Composite, Distributed Applications

    Science.gov (United States)

    Eidson, Thomas M.; Bushnell, Dennis M. (Technical Monitor)

    2001-01-01

    The nature of scientific programming is evolving to larger, composite applications that are composed of smaller element applications. These composite applications are more frequently being targeted for distributed, heterogeneous networks of computers. They are most likely programmed by a group of developers. Software component technology and computational frameworks are being proposed and developed to meet the programming requirements of these new applications. Historically, programming systems have had a hard time being accepted by the scientific programming community. In this paper, a programming model is outlined that attempts to organize the software component concepts and fundamental programming entities into programming abstractions that will be better understood by the application developers. The programming model is designed to support computational frameworks that manage many of the tedious programming details, but also that allow sufficient programmer control to design an accurate, high-performance application.

  14. Simultaneous estimation of transcutaneous bilirubin, hemoglobin, and melanin based on diffuse reflectance spectroscopy

    Science.gov (United States)

    Nishidate, Izumi; Abdul, Wares MD.; Ohtsu, Mizuki; Nakano, Kazuya; Haneishi, Hideaki

    2018-02-01

    We propose a method to estimate transcutaneous bilirubin, hemoglobin, and melanin based on the diffuse reflectance spectroscopy. In the proposed method, the Monte Carlo simulation-based multiple regression analysis for an absorbance spectrum in the visible wavelength region (460-590 nm) is used to specify the concentrations of bilirubin (Cbil), oxygenated hemoglobin (Coh), deoxygenated hemoglobin (Cdh), and melanin (Cm). Using the absorbance spectrum calculated from the measured diffuse reflectance spectrum as a response variable and the extinction coefficients of bilirubin, oxygenated hemoglobin, deoxygenated hemoglobin, and melanin, as predictor variables, multiple regression analysis provides regression coefficients. Concentrations of bilirubin, oxygenated hemoglobin, deoxygenated hemoglobin, and melanin, are then determined from the regression coefficients using conversion vectors that are numerically deduced in advance by the Monte Carlo simulations for light transport in skin. Total hemoglobin concentration (Cth) and tissue oxygen saturation (StO2) are simply calculated from the oxygenated hemoglobin and deoxygenated hemoglobin. In vivo animal experiments with bile duct ligation in rats demonstrated that the estimated Cbil is increased after ligation of bile duct and reaches to around 20 mg/dl at 72 h after the onset of the ligation, which corresponds to the reference value of Cbil measured by a commercially available transcutaneous bilirubin meter. We also performed in vivo experiments with rats while varying the fraction of inspired oxygen (FiO2). Coh and Cdh decreased and increased, respectively, as FiO2 decreased. Consequently, StO2 was dramatically decreased. The results in this study indicate potential of the method for simultaneous evaluation of multiple chromophores in skin tissue.

  15. An Improved Otsu Threshold Segmentation Method for Underwater Simultaneous Localization and Mapping-Based Navigation

    Directory of Open Access Journals (Sweden)

    Xin Yuan

    2016-07-01

    Full Text Available The main focus of this paper is on extracting features with SOund Navigation And Ranging (SONAR sensing for further underwater landmark-based Simultaneous Localization and Mapping (SLAM. According to the characteristics of sonar images, in this paper, an improved Otsu threshold segmentation method (TSM has been developed for feature detection. In combination with a contour detection algorithm, the foreground objects, although presenting different feature shapes, are separated much faster and more precisely than by other segmentation methods. Tests have been made with side-scan sonar (SSS and forward-looking sonar (FLS images in comparison with other four TSMs, namely the traditional Otsu method, the local TSM, the iterative TSM and the maximum entropy TSM. For all the sonar images presented in this work, the computational time of the improved Otsu TSM is much lower than that of the maximum entropy TSM, which achieves the highest segmentation precision among the four above mentioned TSMs. As a result of the segmentations, the centroids of the main extracted regions have been computed to represent point landmarks which can be used for navigation, e.g., with the help of an Augmented Extended Kalman Filter (AEKF-based SLAM algorithm. The AEKF-SLAM approach is a recursive and iterative estimation-update process, which besides a prediction and an update stage (as in classical Extended Kalman Filter (EKF, includes an augmentation stage. During navigation, the robot localizes the centroids of different segments of features in sonar images, which are detected by our improved Otsu TSM, as point landmarks. Using them with the AEKF achieves more accurate and robust estimations of the robot pose and the landmark positions, than with those detected by the maximum entropy TSM. Together with the landmarks identified by the proposed segmentation algorithm, the AEKF-SLAM has achieved reliable detection of cycles in the map and consistent map update on loop

  16. An Improved Otsu Threshold Segmentation Method for Underwater Simultaneous Localization and Mapping-Based Navigation.

    Science.gov (United States)

    Yuan, Xin; Martínez, José-Fernán; Eckert, Martina; López-Santidrián, Lourdes

    2016-07-22

    The main focus of this paper is on extracting features with SOund Navigation And Ranging (SONAR) sensing for further underwater landmark-based Simultaneous Localization and Mapping (SLAM). According to the characteristics of sonar images, in this paper, an improved Otsu threshold segmentation method (TSM) has been developed for feature detection. In combination with a contour detection algorithm, the foreground objects, although presenting different feature shapes, are separated much faster and more precisely than by other segmentation methods. Tests have been made with side-scan sonar (SSS) and forward-looking sonar (FLS) images in comparison with other four TSMs, namely the traditional Otsu method, the local TSM, the iterative TSM and the maximum entropy TSM. For all the sonar images presented in this work, the computational time of the improved Otsu TSM is much lower than that of the maximum entropy TSM, which achieves the highest segmentation precision among the four above mentioned TSMs. As a result of the segmentations, the centroids of the main extracted regions have been computed to represent point landmarks which can be used for navigation, e.g., with the help of an Augmented Extended Kalman Filter (AEKF)-based SLAM algorithm. The AEKF-SLAM approach is a recursive and iterative estimation-update process, which besides a prediction and an update stage (as in classical Extended Kalman Filter (EKF)), includes an augmentation stage. During navigation, the robot localizes the centroids of different segments of features in sonar images, which are detected by our improved Otsu TSM, as point landmarks. Using them with the AEKF achieves more accurate and robust estimations of the robot pose and the landmark positions, than with those detected by the maximum entropy TSM. Together with the landmarks identified by the proposed segmentation algorithm, the AEKF-SLAM has achieved reliable detection of cycles in the map and consistent map update on loop closure, which is

  17. A service component-based accounting and charging architecture to support interim mechanisms across multiple domains

    NARCIS (Netherlands)

    Le, M. van; Beijnum, B.J.F. van; Huitema, G.B.

    2004-01-01

    Today, telematics services are often compositions of different chargeable service components offered by different service providers. To enhance component-based accounting and charging, the service composition information is used to match with the corresponding charging structure of a service

  18. SUPER-FMIT, an accelerator-based neutron source for fusion components irradiation testing

    International Nuclear Information System (INIS)

    Burke, R.J.; Holmes, J.J.; Johnson, D.L.; Mann, F.M.; Miles, R.R.

    1984-01-01

    The SUPER-FMIT facility is proposed as an advanced accelerator based neutron source for high flux irradiation testing of large-sized fusion reactor components. The facility would require only small extensions to existing accelerator and target technology originally developed for the Fusion Materials Irradiation Test (FMIT) facility. There, neutrons would be produced by a 0.1 ampere beam of 35 MeV deuterons incident upon a liquid lithium target. The volume available for high flux (> 10 14 n/cm 2 -s) testing in SUPER-FMIT would be 14 liters, about a factor of 30 larger than in the FMIT facility. This is because the effective beam current of 35 MeV deuterons on target can be increased by a factor of ten to 1.0 amperes or more. Such a large increase can be accomplished by acceleration of multiple beams of molecular deuterium ions (D 2 +) to 70 MeV in a common accelerator sructure. The availability of multiple beams and large total current allows great variety in the testing that can be done. For example, fluxes greater than 10 16 n/cm 2 -s, multiple simultaneous experiments, and great flexibility in tailoring of spatial distributions of flux and spectra can be achieved

  19. Conceptual design of a component test facility based on the spherical tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Voss, G.M. [EURATOM-UKAEA Fusion Association, Culham Science Centre, Abingdon OX14 3DB (United Kingdom)], E-mail: garry.voss@ukaea.org.uk; Davis, S. [EURATOM-UKAEA Fusion Association, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Dnestrovskij, A. [I.V. Kurchatov Institute, Moscow (Russian Federation); Kirk, A.; Knight, P.J.; Loughlin, M.; O' Brien, M.H. [EURATOM-UKAEA Fusion Association, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Sychugov, D. [Moscow State University, Moscow (Russian Federation); Tabasso, A. [EURATOM-UKAEA Fusion Association, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Wilson, H.R. [University of York (United Kingdom)

    2008-12-15

    A small steady state spherical tokamak (ST) offers an attractive system for producing simultaneously the neutron, particle and heat fluxes necessary to effectively test and optimise blanket modules, first wall structures and other components under the required fusion power plant conditions. This component test facility (CTF) would complement and extend the qualification of materials by IFMIF and could operate in association with DEMO thus reducing the risk of delays, and extending the options, during this crucial stage of the development of commercial fusion power. The ST-CTF offers many advantages including low tritium consumption, ease of maintenance and a compact assembly and would operate in a strongly driven mode in which Q {approx} 1. The current drive would be provided by a mix of bootstrap current and neutral beam injection systems. The blanket modules under test are removed and replaced using a casking system and the entire centre column assembly can be relatively easily removed via a hydraulic lift system beneath the tokamak assembly. The single turn toroidal field coil has a water-cooled copper centre rod with multiple return limbs, which requires a low voltage, high current power supply. The poloidal field coils are also water-cooled but use a glass fibre reinforced cyanate ester resin insulation that offers higher radiation resistance and higher operating temperatures than the conventional epoxy resin systems. When operated in L-mode most of the exhaust power is directed to the outer legs of the double null divertor configuration where high power densities and high material erosion rates are developed. A novel divertor target based on the use of a cascading flow of pebbles is one option being developed for this application.

  20. Luminex-Based Triplex Immunoassay for the Simultaneous Detection of Soy, Pea and Soluble Wheat proteins in Milk Powder

    NARCIS (Netherlands)

    Haasnoot, W.; Pre, du J.G.

    2007-01-01

    An automated fluorescent microsphere-based flow cytometric triplex immunoassay, using the Luminex 100 flow analyzer with MultiAnalyte Profiling (xMAP) technology, was developed for the simultaneous detection of proteins from three vegetable sources as potential fraudulent adulterants in milk powder.

  1. Compressed sensing based simultaneous black- and gray-blood carotid vessel wall MR imaging.

    Science.gov (United States)

    Li, Bo; Li, Hao; Kong, Hanjing; Dong, Li; Zhang, Jue; Fang, Jing

    2017-05-01

    In this study, we sought to demonstrate the blood suppression performance, image quality and morphological measurements for compressed sensing (CS) based simultaneous 3D black- and gray-blood imaging sequence (CS-siBLAG) in carotid vessel wall MR imaging. Seven healthy volunteers and five patients were recruited. Healthy subjects underwent five CS-siBLAG scans with 1, 2, 3, 4 and 5-fold accelerations. Signal-to-tissue ratio (STR) and contrast-to-tissue ratio (CTR) were computed as the measures of flowing signal suppression performance and the image quality for black-blood imaging of the technique. Vessel lumen area (LA) and wall area (WA) were compared between fully sampled acquisition and each accelerated acquisition. Patients underwent three CS-siBLAG scans with 1, 3 and 5-fold accelerations as well as a 3D time of flight (3D TOF) scan. Two radiologists reviewed the under-sampled black- and gray-blood image quality. STR and CTR values obtained with 2 to 5-fold accelerations were not significantly different from those with full acquisition. LA and WA measured at 2×, 3×, 4× and 5× were all highly correlated to the corresponding values at 1×. For patients imaging, two radiologists both found that the dual-contrast images at 3× acceleration exhibited comparable image quality to that of the fully sampled acquisition, and that the images at 5× exhibited slightly blurred vessel wall and outer vessel wall boundaries. By combining the CS under-sampling pattern and reconstruction, pseudo-centric phase encoding order and dual blood contrast sequences, this technique provides spatially registered black- and gray-blood images and excellent visualization for vessel wall imaging and gray-blood imaging in a short scan time. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Component-Based Approach for Educating Students in Bioinformatics

    Science.gov (United States)

    Poe, D.; Venkatraman, N.; Hansen, C.; Singh, G.

    2009-01-01

    There is an increasing need for an effective method of teaching bioinformatics. Increased progress and availability of computer-based tools for educating students have led to the implementation of a computer-based system for teaching bioinformatics as described in this paper. Bioinformatics is a recent, hybrid field of study combining elements of…

  3. Changes in monosaccharides, organic acids and amino acids during Cabernet Sauvignon wine ageing based on a simultaneous analysis using gas chromatography-mass spectrometry.

    Science.gov (United States)

    Zhang, Xin-Ke; Lan, Yi-Bin; Zhu, Bao-Qing; Xiang, Xiao-Feng; Duan, Chang-Qing; Shi, Ying

    2018-01-01

    Monosaccharides, organic acids and amino acids are the important flavour-related components in wines. The aim of this article is to develop and validate a method that could simultaneously analyse these compounds in wine based on silylation derivatisation and gas chromatography-mass spectrometry (GC-MS), and apply this method to the investigation of the changes of these compounds and speculate upon their related influences on Cabernet Sauvignon wine flavour during wine ageing. This work presented a new approach for wine analysis and provided more information concerning red wine ageing. This method could simultaneously quantitatively analyse 2 monosaccharides, 8 organic acids and 13 amino acids in wine. A validation experiment showed good linearity, sensitivity, reproducibility and recovery. Multiple derivatives of five amino acids have been found but their effects on quantitative analysis were negligible, except for methionine. The evolution pattern of each category was different, and we speculated that the corresponding mechanisms involving microorganism activities, physical interactions and chemical reactions had a great correlation with red wine flavours during ageing. Simultaneously quantitative analysis of monosaccharides, organic acids and amino acids in wine was feasible and reliable and this method has extensive application prospects. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  4. Multiwave generation of the Stokes components in lasers with an SRS self-converter based on an Nd3+:KGd(WO4)2 crystal

    International Nuclear Information System (INIS)

    Gulin, A V; Narkhova, G I; Ustimenko, N S

    1998-01-01

    An experimental investigation was made of multi- wave generation of radiation pulses of ∼ 5 ns duration in lasers with a self-converter based on stimulated Raman scattering in an Nd 3+ :KGd(WO 4 ) 2 crystal. The efficiency of conversion to the first Stokes component with the wavelength 1.18 μm was about 70% and simultaneous generation was possible at three wavelengths (1.067, 1.18, and 1.32 μm), each with the same intensity. Simultaneous generation of 14 wavelengths was observed. (nonlinear optical phenomena)

  5. Multiwavelength Raman-fiber-laser-based long-distance remote sensor for simultaneous measurement of strain and temperature.

    Science.gov (United States)

    Han, Young-Geun; Tran, T V A; Kim, Sang-Hyuck; Lee, Sang Bae

    2005-06-01

    We propose a simple and flexible multiwavelength Raman-fiber-laser-based long-distance remote-sensing scheme for simultaneous measurement of strain and temperature by use of fiber Bragg gratings. By combining two uniform fiber Bragg gratings with a tunable chirped fiber grating, we readily achieve simultaneous two-channel sensing probes with a high extinction ratio of more than approximately 50 dB over a 50-km distance. When strain and temperature are applied, lasing wavelength separation and shift occur, respectively, since the two uniform fiber Bragg gratings have identical material composition and different cladding diameters. This allows simultaneous measurement of strain and temperature for long-distance sensing applications of more than 50 km.

  6. Alpha–beta monitoring system based on pair of simultaneous Multi-Wire Proportional Counters

    Energy Technology Data Exchange (ETDEWEB)

    Wengrowicz, U.; Amidan, D. [Department of Nuclear Engineering, Ben Gurion University of the Negev, Beer-Sheva 84105 (Israel); NRC-Negev, P.O. Box 9001, Beer-Sheva 84190 (Israel); Orion, I. [Department of Nuclear Engineering, Ben Gurion University of the Negev, Beer-Sheva 84105 (Israel)

    2016-08-11

    A new approach for a simultaneous alpha–beta Multi-wire Proportional Counter (MWPC) is presented. The popular approach for alpha–beta monitoring systems consists of a large area MWPC using noble gas flow such as Argon Methane. This method of measurement is effective but requires large-scale and expensive maintenance due to the needs of gas flow control and periodic replacements. In this work, a pair of simultaneous MWPCs for alpha–beta measuring is presented. The developed detector consists of a sealed gas MWPC sensor for beta particles, behind a free air alpha sensor. This approach allows effective simultaneous detection and discrimination of both alpha and beta radiation without the maintenance cost noble gas flow required for unsealed detectors.

  7. Critical components for diamond-based quantum coherent devices

    International Nuclear Information System (INIS)

    Greentree, Andrew D; Olivero, Paolo; Draganski, Martin; Trajkov, Elizabeth; Rabeau, James R; Reichart, Patrick; Gibson, Brant C; Rubanov, Sergey; Huntington, Shane T; Jamieson, David N; Prawer, Steven

    2006-01-01

    The necessary elements for practical devices exploiting quantum coherence in diamond materials are summarized, and progress towards their realization documented. A brief review of future prospects for diamond-based devices is also provided

  8. Principles of Component-Based Design of Intelligent Agents

    NARCIS (Netherlands)

    Brazier, F.M.; Jonker, C.M.; Treur, J.

    Compositional multi-agent system design is a methodological perspective on multi-agent system design based on the software engineering principles process and knowledge abstraction, compositionality, reuse, specification and verification. This paper addresses these principles from a generic

  9. Principles of component-based design of intelligent agents.

    NARCIS (Netherlands)

    Brazier, F.M.T.; Jonker, C.M.; Treur, J.

    2002-01-01

    Compositional multi-agent system design is a methodological perspective on multi-agent system design based on the software engineering principles process and knowledge abstraction, compositionality, reuse, specification and verification. This paper addresses these principles from a generic

  10. GENERIC, COMPONENT FAILURE DATA BASE FOR LIGHT WATER AND LIQUID SODIUM REACTOR PRAs

    Energy Technology Data Exchange (ETDEWEB)

    S. A. Eide; S. V. Chmielewski; T. D. Swantz

    1990-02-01

    A comprehensive generic component failure data base has been developed for light water and liquid sodium reactor probabilistic risk assessments (PRAs) . The Nuclear Computerized Library for Assessing Reactor Reliability (NUCLARR) and the Centralized Reliability Data Organization (CREDO) data bases were used to generate component failure rates . Using this approach, most of the failure rates are based on actual plant data rather than existing estimates .

  11. EEG-Based Emotion Recognition Using Deep Learning Network with Principal Component Based Covariate Shift Adaptation

    Directory of Open Access Journals (Sweden)

    Suwicha Jirayucharoensak

    2014-01-01

    Full Text Available Automatic emotion recognition is one of the most challenging tasks. To detect emotion from nonstationary EEG signals, a sophisticated learning algorithm that can represent high-level abstraction is required. This study proposes the utilization of a deep learning network (DLN to discover unknown feature correlation between input signals that is crucial for the learning task. The DLN is implemented with a stacked autoencoder (SAE using hierarchical feature learning approach. Input features of the network are power spectral densities of 32-channel EEG signals from 32 subjects. To alleviate overfitting problem, principal component analysis (PCA is applied to extract the most important components of initial input features. Furthermore, covariate shift adaptation of the principal components is implemented to minimize the nonstationary effect of EEG signals. Experimental results show that the DLN is capable of classifying three different levels of valence and arousal with accuracy of 49.52% and 46.03%, respectively. Principal component based covariate shift adaptation enhances the respective classification accuracy by 5.55% and 6.53%. Moreover, DLN provides better performance compared to SVM and naive Bayes classifiers.

  12. Component alignment and functional outcome following computer assisted and jig based total knee arthroplasty

    Directory of Open Access Journals (Sweden)

    Dnyanesh G Lad

    2013-01-01

    Conclusions: A significantly improved placement of the component was found in the coronal and sagittal planes of the tibial component by CAS. The placement of the components in the other planes was comparable with the values recorded in the jig-based surgery group. Functional outcome was not significantly different.

  13. Component fragility data base for reliability and probability studies

    International Nuclear Information System (INIS)

    Bandyopadhyay, K.; Hofmayer, C.; Kassir, M.; Pepper, S.

    1989-01-01

    Safety-related equipment in a nuclear plant plays a vital role in its proper operation and control, and failure of such equipment due to an earthquake may pose a risk to the safe operation of the plant. Therefore, in order to assess the overall reliability of a plant, the reliability of performance of the equipment should be studied first. The success of a reliability or a probability study depends to a great extent on the data base. To meet this demand, Brookhaven National Laboratory (BNL), under a sponsorship of the United States Nuclear Regulatory Commission (USNRC), has formed a test data base relating the seismic capacity of equipment specimens to the earthquake levels. Subsequently, the test data have been analyzed for use in reliability and probability studies. This paper describes the data base and discusses the analysis methods. The final results that can be directly used in plant reliability and probability studies are also presented in this paper. 2 refs., 2 tabs

  14. Component fragility data base for reliability and probability studies

    International Nuclear Information System (INIS)

    Bandyopadhyay, K.; Hofmayer, C.; Kassier, M.; Pepper, S.

    1989-01-01

    Safety-related equipment in a nuclear plant plays a vital role in its proper operation and control, and failure of such equipment due to an earthquake may pose a risk to the safe operation of the plant. Therefore, in order to assess the overall reliability of a plant, the reliability of performance of the equipment should be studied first. The success of a reliability or a probability study depends to a great extent on the data base. To meet this demand, Brookhaven National Laboratory (BNL) has formed a test data base relating the seismic capacity of equipment specimens to the earthquake levels. Subsequently, the test data have been analyzed for use in reliability and probability studies. This paper describes the data base and discusses the analysis methods. The final results that can be directly used in plant reliability and probability studies are also presented in this paper

  15. Laser-based target tracking using principal component descriptors

    CSIR Research Space (South Africa)

    Burke, Michael G

    2010-11-01

    Full Text Available ]. Here, supervised learning was applied to the problem of building a classifier for the detection of people. Their approach used AdaBoost to create a strong classifier by combining a set of weak classifiers. Their classifier consisted of 14... of classifiers based on the 14 features of [5] in the context of pedestrian detection. A better classifier, which uses AdaBoost to train a classifier using a probabilistic part-based model of geometric laser primitives in conjunction with omnidirectional...

  16. Component-Based Engineering of Knowledge-Enabled Systems: Research Vision and Strategy

    National Research Council Canada - National Science Library

    Goodburn, D

    2001-01-01

    ...'. The Software Systems Engineering (SSE) group of ITD is currently conducting research into new software engineering principles and practices, collectively referred to as component-based software...

  17. Selection of independent components based on cortical mapping of electromagnetic activity

    Science.gov (United States)

    Chan, Hui-Ling; Chen, Yong-Sheng; Chen, Li-Fen

    2012-10-01

    Independent component analysis (ICA) has been widely used to attenuate interference caused by noise components from the electromagnetic recordings of brain activity. However, the scalp topographies and associated temporal waveforms provided by ICA may be insufficient to distinguish functional components from artifactual ones. In this work, we proposed two component selection methods, both of which first estimate the cortical distribution of the brain activity for each component, and then determine the functional components based on the parcellation of brain activity mapped onto the cortical surface. Among all independent components, the first method can identify the dominant components, which have strong activity in the selected dominant brain regions, whereas the second method can identify those inter-regional associating components, which have similar component spectra between a pair of regions. For a targeted region, its component spectrum enumerates the amplitudes of its parceled brain activity across all components. The selected functional components can be remixed to reconstruct the focused electromagnetic signals for further analysis, such as source estimation. Moreover, the inter-regional associating components can be used to estimate the functional brain network. The accuracy of the cortical activation estimation was evaluated on the data from simulation studies, whereas the usefulness and feasibility of the component selection methods were demonstrated on the magnetoencephalography data recorded from a gender discrimination study.

  18. Simultaneous imaging using Si-PM-based PET and MRI for development of an integrated PET/MRI system

    Science.gov (United States)

    Yamamoto, Seiichi; Watabe, Tadashi; Watabe, Hiroshi; Aoki, Masaaki; Sugiyama, Eiji; Imaizumi, Masao; Kanai, Yasukazu; Shimosegawa, Eku; Hatazawa, Jun

    2012-01-01

    The silicon photomultiplier (Si-PM) is a promising photo-detector for PET for use in magnetic resonance imaging (MRI) systems because it has high gain and is insensitive to static magnetic fields. Recently we developed a Si-PM-based depth-of-interaction PET system for small animals and performed simultaneous measurements by combining the Si-PM-based PET and the 0.15 T permanent MRI to test the interferences between the Si-PM-based PET and an MRI. When the Si-PM was inside the MRI and installed around the radio frequency (RF) coil of the MRI, significant noise from the RF sequence of the MRI was observed in the analog signals of the PET detectors. However, we did not observe any artifacts in the PET images; fluctuation increased in the count rate of the Si-PM-based PET system. On the MRI side, there was significant degradation of the signal-to-noise ratio (S/N) in the MRI images compared with those without PET. By applying noise reduction procedures, the degradation of the S/N was reduced. With this condition, simultaneous measurements of a rat brain using a Si-PM-based PET and an MRI were made with some degradation in the MRI images. We conclude that simultaneous measurements are possible using Si-PM-based PET and MRI.

  19. Simultaneous imaging using Si-PM-based PET and MRI for development of an integrated PET/MRI system

    International Nuclear Information System (INIS)

    Yamamoto, Seiichi; Watabe, Tadashi; Imaizumi, Masao; Shimosegawa, Eku; Hatazawa, Jun; Watabe, Hiroshi; Kanai, Yasukazu; Aoki, Masaaki; Sugiyama, Eiji

    2012-01-01

    The silicon photomultiplier (Si-PM) is a promising photo-detector for PET for use in magnetic resonance imaging (MRI) systems because it has high gain and is insensitive to static magnetic fields. Recently we developed a Si-PM-based depth-of-interaction PET system for small animals and performed simultaneous measurements by combining the Si-PM-based PET and the 0.15 T permanent MRI to test the interferences between the Si-PM-based PET and an MRI. When the Si-PM was inside the MRI and installed around the radio frequency (RF) coil of the MRI, significant noise from the RF sequence of the MRI was observed in the analog signals of the PET detectors. However, we did not observe any artifacts in the PET images; fluctuation increased in the count rate of the Si-PM-based PET system. On the MRI side, there was significant degradation of the signal-to-noise ratio (S/N) in the MRI images compared with those without PET. By applying noise reduction procedures, the degradation of the S/N was reduced. With this condition, simultaneous measurements of a rat brain using a Si-PM-based PET and an MRI were made with some degradation in the MRI images. We conclude that simultaneous measurements are possible using Si-PM-based PET and MRI. (note)

  20. Simultaneous Optimization of Block Replacement and Spare Part Ordering TIME for a Multi Component System with Separate Spare Part Ordering for Block and Failure Replacements

    OpenAIRE

    Mardin, Farid; Dekker, Rommert

    2016-01-01

    A block replacement schedule can be optimized simultaneously with a spare parts ordering schedule, since all items are replaced at a constant interval. The solution of joint optimization for spare parts ordering time and block replacement gives lower costs compared to separate optimization of ordering time and replacement time. The spare parts for replacement can be classified as stochastic demand for failure replacement and deterministic demand for block replacement. In this paper, we propos...

  1. FPGA-based RF interference reduction techniques for simultaneous PET–MRI

    Science.gov (United States)

    Gebhardt, P; Wehner, J; Weissler, B; Botnar, R; Marsden, P K; Schulz, V

    2016-01-01

    Abstract The combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) as a multi-modal imaging technique is considered very promising and powerful with regard to in vivo disease progression examination, therapy response monitoring and drug development. However, PET–MRI system design enabling simultaneous operation with unaffected intrinsic performance of both modalities is challenging. As one of the major issues, both the PET detectors and the MRI radio-frequency (RF) subsystem are exposed to electromagnetic (EM) interference, which may lead to PET and MRI signal-to-noise ratio (SNR) deteriorations. Early digitization of electronic PET signals within the MRI bore helps to preserve PET SNR, but occurs at the expense of increased amount of PET electronics inside the MRI and associated RF field emissions. This raises the likelihood of PET-related MRI interference by coupling into the MRI RF coil unwanted spurious signals considered as RF noise, as it degrades MRI SNR and results in MR image artefacts. RF shielding of PET detectors is a commonly used technique to reduce PET-related RF interferences, but can introduce eddy-current-related MRI disturbances and hinder the highest system integration. In this paper, we present RF interference reduction methods which rely on EM field coupling–decoupling principles of RF receive coils rather than suppressing emitted fields. By modifying clock frequencies and changing clock phase relations of digital circuits, the resulting RF field emission is optimised with regard to a lower field coupling into the MRI RF coil, thereby increasing the RF silence of PET detectors. Our methods are demonstrated by performing FPGA-based clock frequency and phase shifting of digital silicon photo-multipliers (dSiPMs) used in the PET modules of our MR-compatible Hyperion IID PET insert. We present simulations and magnetic-field map scans visualising the impact of altered clock phase pattern on the spatial RF field

  2. FPGA-based RF interference reduction techniques for simultaneous PET-MRI

    Science.gov (United States)

    Gebhardt, P.; Wehner, J.; Weissler, B.; Botnar, R.; Marsden, P. K.; Schulz, V.

    2016-05-01

    The combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) as a multi-modal imaging technique is considered very promising and powerful with regard to in vivo disease progression examination, therapy response monitoring and drug development. However, PET-MRI system design enabling simultaneous operation with unaffected intrinsic performance of both modalities is challenging. As one of the major issues, both the PET detectors and the MRI radio-frequency (RF) subsystem are exposed to electromagnetic (EM) interference, which may lead to PET and MRI signal-to-noise ratio (SNR) deteriorations. Early digitization of electronic PET signals within the MRI bore helps to preserve PET SNR, but occurs at the expense of increased amount of PET electronics inside the MRI and associated RF field emissions. This raises the likelihood of PET-related MRI interference by coupling into the MRI RF coil unwanted spurious signals considered as RF noise, as it degrades MRI SNR and results in MR image artefacts. RF shielding of PET detectors is a commonly used technique to reduce PET-related RF interferences, but can introduce eddy-current-related MRI disturbances and hinder the highest system integration. In this paper, we present RF interference reduction methods which rely on EM field coupling-decoupling principles of RF receive coils rather than suppressing emitted fields. By modifying clock frequencies and changing clock phase relations of digital circuits, the resulting RF field emission is optimised with regard to a lower field coupling into the MRI RF coil, thereby increasing the RF silence of PET detectors. Our methods are demonstrated by performing FPGA-based clock frequency and phase shifting of digital silicon photo-multipliers (dSiPMs) used in the PET modules of our MR-compatible Hyperion II D PET insert. We present simulations and magnetic-field map scans visualising the impact of altered clock phase pattern on the spatial RF field distribution

  3. Aluminosilicate-based adsorbent in equimolar and non-equimolar binary-component heavy metal removal systems.

    Science.gov (United States)

    Xu, Meng; Hadi, Pejman; Ning, Chao; Barford, John; An, Kyoung Jin; McKay, Gordon

    2015-01-01

    Cadmium (Cd) and lead (Pb) are toxic heavy metals commonly used in various industries. The simultaneous presence of these metals in wastewater amplifies the toxicity of wastewater and the complexity of the treatment process. This study has investigated the selective behavior of an aluminosilicate-based mesoporous adsorbent. It has been demonstrated that when equimolar quantities of the metals are present in wastewater, the adsorbent uptakes the Pb²⁺ ions selectively. This has been attributed to the higher electronegativity value of Pb²⁺ compared to Cd²⁺ which can be more readily adsorbed on the adsorbent surface, displacing the Cd²⁺ ions. The selectivity can be advantageous when the objective is the separation and reuse of the metals besides wastewater treatment. In non-equimolar solutions, a complete selectivity can be observed up to a threshold Pb²⁺ molar ratio of 30%. Below this threshold value, the Cd²⁺ and Pb²⁺ ions are uptaken simultaneously due to the abundance of Cd²⁺ ions and the availability of adsorption sites at very low Pb²⁺ molar ratios. Moreover, the total adsorption capacities of the adsorbent for the multi-component system have been shown to be in the same range as the single-component system for each metal ion which can be of high value for industrial applications.

  4. Modeling media as latent semantics based on cognitive components

    DEFF Research Database (Denmark)

    Petersen, Michael Kai

    Though one might think of media as an audiovisual stream of consciousness, we frequently encode frames of video sequences and waves of sound into strings of text. Language allows us to both share the internal representations of what we perceive as mental concepts, as well as categorizing them...... of media based on lyrics, synopses, subtitles, blogs or web pages associated with the content. In the proposed model the bottom-up generated sensory input is a matrix of tens of thousands of words co-occurring within multiple contexts, that are in turn represented as vectors in a semantic space of reduced...... with aspects of cognitive linguistics that potentially could be utilized in applications ranging from information retrieval and media personalization, to emotional brand building or neuroscientific modeling of syntax and semantics....

  5. Low-power adaptive filter based on RNS components

    DEFF Research Database (Denmark)

    Bernocchi, Gian Luca; Cardarilli, Gian Carlo; Del Re, Andrea

    2007-01-01

    In this paper a low-power implementation of an adaptive FIR filter is presented. The filter is designed to meet the constraints of channel equalization for fixed wireless communications that typically requires a large number of taps, but a serial updating of the filter coefficients, based...... on the least mean squares (LMS) algorithm, is allowed. Previous work showed that the use of the residue number system (RNS) for the variable FIR filter grants advantages both in area and power consumption. On the other hand, the use of a binary serial implementation of the adaptation algorithm eliminates...... the need for complex scaling circuits in RNS. The advantages in terms of area and speed of the presented filter, with respect to its two's complement counterpart, are evaluated for implementations in standard cells....

  6. Simultaneous Optimal Placement of Distributed Generation and Electric Vehicle Parking Lots Based on Probabilistic EV Model

    OpenAIRE

    M.H. Amini; M. Parsa Moghaddam

    2013-01-01

    High penetration of distributed generations and the increasing demand for using electric vehicles provide a lot of issues for the utilities. If these two effective elements of the future power system are used in an unscheduled manner, it may lead to the loss increment in distribution networks, dramatically. In this paper, the simultaneous allocation of distributed generations (DGs) and electric vehicles (EVs) parking lots has been studied in a radial distribution network. A distribution netwo...

  7. Striatal and Hippocampal Entropy and Recognition Signals in Category Learning: Simultaneous Processes Revealed by Model-Based fMRI

    Science.gov (United States)

    Davis, Tyler; Love, Bradley C.; Preston, Alison R.

    2012-01-01

    Category learning is a complex phenomenon that engages multiple cognitive processes, many of which occur simultaneously and unfold dynamically over time. For example, as people encounter objects in the world, they simultaneously engage processes to determine their fit with current knowledge structures, gather new information about the objects, and adjust their representations to support behavior in future encounters. Many techniques that are available to understand the neural basis of category learning assume that the multiple processes that subserve it can be neatly separated between different trials of an experiment. Model-based functional magnetic resonance imaging offers a promising tool to separate multiple, simultaneously occurring processes and bring the analysis of neuroimaging data more in line with category learning’s dynamic and multifaceted nature. We use model-based imaging to explore the neural basis of recognition and entropy signals in the medial temporal lobe and striatum that are engaged while participants learn to categorize novel stimuli. Consistent with theories suggesting a role for the anterior hippocampus and ventral striatum in motivated learning in response to uncertainty, we find that activation in both regions correlates with a model-based measure of entropy. Simultaneously, separate subregions of the hippocampus and striatum exhibit activation correlated with a model-based recognition strength measure. Our results suggest that model-based analyses are exceptionally useful for extracting information about cognitive processes from neuroimaging data. Models provide a basis for identifying the multiple neural processes that contribute to behavior, and neuroimaging data can provide a powerful test bed for constraining and testing model predictions. PMID:22746951

  8. Simultaneous determination of cadaverine and putrescine using a disposable monoamine oxidase based biosensor.

    Science.gov (United States)

    Henao-Escobar, Wilder; Domínguez-Renedo, Olga; Asunción Alonso-Lomillo, M; Julia Arcos-Martínez, M

    2013-12-15

    The selective and simultaneous amperometric determination of putrescine (Put) and cadaverine (Cad) has been carried out using a novel design of screen-printed carbon electrode (SPCE) with two working electrodes connected in array mode. A mixture of 3% of tetrathiafulvalene (TTF), as mediator, and carbon ink was used for the construction of the screen-printed working electrode. The employment of different amounts of monoamine oxidase (MAO) enzyme on these modified TTF/SPCEs and the use of gold nanoparticles (AuNPs) allowed performing the simultaneous determination of both analytes. The amperometric detection has been performed by measuring the oxidation current of the mediator at a potential of+250 mV vs. screen-printed Ag/AgCl reference electrode. A linear response in the Cad concentration range from 19.6 till 107.1 µM and from 9.9 till 74.1 μM for Put was obtained at the MAO/AuNPs/TTF/SPCE biosensor. This device showed a capability of detection of 9.9 and 19.9±0.9 µM (n=4 α=β=0.05) and a precision of 4.9% and 10.3% in terms of relative standard deviation for Put and Cad, respectively. The developed biosensor was successfully applied to the simultaneous determination of Put and Cad in octopus samples. © 2013 Elsevier B.V. All rights reserved.

  9. Model-Checking of Component-Based Event-Driven Real-Time Embedded Software

    National Research Council Canada - National Science Library

    Gu, Zonghua; Shin, Kang G

    2005-01-01

    .... We discuss application of model-checking to verify system-level concurrency properties of component-based real-time embedded software based on CORBA Event Service, using Avionics Mission Computing...

  10. Condition Based Monitoring of Gas Turbine Combustion Components

    Energy Technology Data Exchange (ETDEWEB)

    Ulerich, Nancy; Kidane, Getnet; Spiegelberg, Christine; Tevs, Nikolai

    2012-09-30

    The objective of this program is to develop sensors that allow condition based monitoring of critical combustion parts of gas turbines. Siemens teamed with innovative, small companies that were developing sensor concepts that could monitor wearing and cracking of hot turbine parts. A magnetic crack monitoring sensor concept developed by JENTEK Sensors, Inc. was evaluated in laboratory tests. Designs for engine application were evaluated. The inability to develop a robust lead wire to transmit the signal long distances resulted in a discontinuation of this concept. An optical wear sensor concept proposed by K Sciences GP, LLC was tested in proof-of concept testing. The sensor concept depended, however, on optical fiber tips wearing with the loaded part. The fiber tip wear resulted in too much optical input variability; the sensor could not provide adequate stability for measurement. Siemens developed an alternative optical wear sensor approach that used a commercial PHILTEC, Inc. optical gap sensor with an optical spacer to remove fibers from the wearing surface. The gap sensor measured the length of the wearing spacer to follow loaded part wear. This optical wear sensor was developed to a Technology Readiness Level (TRL) of 5. It was validated in lab tests and installed on a floating transition seal in an F-Class gas turbine. Laboratory tests indicate that the concept can measure wear on loaded parts at temperatures up to 800{degrees}C with uncertainty of < 0.3 mm. Testing in an F-Class engine installation showed that the optical spacer wore with the wearing part. The electro-optics box located outside the engine enclosure survived the engine enclosure environment. The fiber optic cable and the optical spacer, however, both degraded after about 100 operating hours, impacting the signal analysis.

  11. Research on development model of nuclear component based on life cycle management

    International Nuclear Information System (INIS)

    Bao Shiyi; Zhou Yu; He Shuyan

    2005-01-01

    At present the development process of nuclear component, even nuclear component itself, is more and more supported by computer technology. This increasing utilization of the computer and software has led to the faster development of nuclear technology on one hand and also brought new problems on the other hand. Especially, the combination of hardware, software and humans has increased nuclear component system complexities to an unprecedented level. To solve this problem, Life Cycle Management technology is adopted in nuclear component system. Hence, an intensive discussion on the development process of a nuclear component is proposed. According to the characteristics of the nuclear component development, such as the complexities and strict safety requirements of the nuclear components, long-term design period, changeable design specifications and requirements, high capital investment, and satisfaction for engineering codes/standards, the development life-cycle model of nuclear component is presented. The development life-cycle model is classified at three levels, namely, component level development life-cycle, sub-component development life-cycle and component level verification/certification life-cycle. The purposes and outcomes of development processes are stated in detailed. A process framework for nuclear component based on system engineering and development environment of nuclear component is discussed for future research work. (authors)

  12. Analysis of appraisal tool of system security engineering capability maturity based on component

    International Nuclear Information System (INIS)

    Liu Zhenghai; Yang Xiaohua; Zou Shuliang; Liu Yachun; Xiao Jiantian; Liu Zhiming

    2012-01-01

    Spent Fuel Reprocessing is a part of nuclear fuel cycle and is the inevitably choice of nuclear power sustainable development. Reprocessing needs to face with radiological, criticality, chemical hazards. Besides using the tradition appraisal methods based on the security goals, it is a beneficial supplement that using the appraisal method of system security engineering capability maturity model based on the process. Experts should check and approve large numbers of documents during the appraisal based on system security engineering capability maturity model, so it is necessary that developing a tool to assist the expert to complete the appraisal. The method of developing software based on component is highly effective, nimble and reliable. Component technology is analyzed, the methods of extraction model domain components and general components is introduced, and the appraisal system is developed based on component technology. (authors)

  13. Reliability-based sensitivity of mechanical components with arbitrary distribution parameters

    International Nuclear Information System (INIS)

    Zhang, Yi Min; Yang, Zhou; Wen, Bang Chun; He, Xiang Dong; Liu, Qiaoling

    2010-01-01

    This paper presents a reliability-based sensitivity method for mechanical components with arbitrary distribution parameters. Techniques from the perturbation method, the Edgeworth series, the reliability-based design theory, and the sensitivity analysis approach were employed directly to calculate the reliability-based sensitivity of mechanical components on the condition that the first four moments of the original random variables are known. The reliability-based sensitivity information of the mechanical components can be accurately and quickly obtained using a practical computer program. The effects of the design parameters on the reliability of mechanical components were studied. The method presented in this paper provides the theoretic basis for the reliability-based design of mechanical components

  14. Coupling non invasive and fast sampling of proteins from work of art surfaces to surface plasmon resonance biosensing: Differential and simultaneous detection of egg components for cultural heritage diagnosis and conservation.

    Science.gov (United States)

    Scarano, S; Carretti, E; Dei, L; Baglioni, P; Minunni, M

    2016-11-15

    Despite the wide application of surface plasmon resonance (SPR) to a broad area of interests, from environment to food analysis, from drug discovery to diagnostics, its exploitation in cultural heritage conservation is still unexplored. Water-based highly viscous polymeric dispersions (HVPD) composed by partially hydrolyzed polyvinyl acetate (PVA), borax, and water, were recently developed and successfully applied for the selective removal of surface degradation patinas (i.e. protein materials, natural resins etc.) from paintings of historical and artistic interest. This approach is here coupled for the first time to a SPR biosensor to simultaneously recognize albumen, yolk, or their mixtures in HVPD extracts. Ovalbumin and immunoglobulin Y are selected as analytes for egg white and yolk recognition, respectively. The biosensor was first characterized on standard analytes within the range 0-400mgL(-1) and then on fresh and dried egg albumen and yolk down to 2·10(^4) and 1·10(^5) dilution factors, respectively. Once optimized, the biosensor was combined to the HVPD application on simulated and real art samples for the evaluation of hen egg presence in the extract, i.e. albumen, yolk, or their co-presence in the matrix. For a contemporary 'sacred icon', realized by the traditional egg tempera procedure described by Cennino Cennini, the biosensor successfully distinguished different uses of egg components for the realization of painted and gilded areas, i.e. yolk and albumen, respectively. Finally, a XVIII century italian painting whose the realization technique is unknown, was tested confirming its egg tempera-based realization technique. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Multi-color quantum dot-based fluorescence immunoassay array for simultaneous visual detection of multiple antibiotic residues in milk.

    Science.gov (United States)

    Song, Erqun; Yu, Mengqun; Wang, Yunyun; Hu, Weihua; Cheng, Dan; Swihart, Mark T; Song, Yang

    2015-10-15

    Antibiotic residues, which are among the most common contaminants in animal-based food products such as milk, have become a significant public health concern. Here, we combine a multicolor quantum dot (QD)-based immunofluorescence assay and an array analysis method to achieve simultaneous, sensitive and visual detection of streptomycin (SM), tetracycline (TC), and penicillin G (PC-G) in milk. Antibodies (Abs) for SM, TC and PC-G were conjugated to QDs with different emission wavelengths (QD 520 nm, QD 565 nm and QD 610 nm) to serve as detection probes (QD-Ab). Then a direct competitive fluorescent immunoassay was performed in antigen-coated microtiter plate wells for simultaneous qualitative and quantitative detection of SM, TC, and PC-G residues, based on fluorescence of the QD-Ab probes. The linear ranges for SM, TC and PC-G were 0.01-25 ng/mL, 0.01-25 ng/mL and 0.01-10 ng/mL, respectively, with detection limit of 5 pg/mL for each of them. Based on fluorescence of the QD-Ab probes, residues of the three antibiotics were determined visually and simultaneously. Compared with a commercial enzyme-linked immunosorbent assay kit, our method could achieve simultaneous analysis of multiple target antibiotics in multiple samples in a single run (high-throughput analysis) and improved accuracy and sensitivity for analysis of residues of the three antibiotics in authentic milk samples. This new analytical tool can play an important role in ameliorating the negative impact of the residual antibiotics on human health and the ecosystem. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. Bidirectional and simultaneous FTTX/Ethernet services using RSOA based remodulation and polarization multiplexing technique

    Science.gov (United States)

    Das, Anindya S.; Patra, Ardhendu S.

    2015-08-01

    A bidirectional and simultaneous transmission of Ethernet, FTTX services through single optical carrier wavelength employing polarization multiplexing technique in the transmitter end and the user end. 10 Gbps and 2.5 Gbps datarates are transmitted over 50 km single mode fiber employing POLMUX technique at OLT and ONU to provide Ethernet and FTTX services concurrently to the user. Reflective semiconductor optical amplifier is used to reuse and remodulate the downlink signal to uplink transmission. The upstream and the downstream transmission performances are observed by the bit error rate values and the eye diagrams obtained by the BER analyzer.

  17. Feedback loops and temporal misalignment in component-based hydrologic modeling

    Science.gov (United States)

    Elag, Mostafa M.; Goodall, Jonathan L.; Castronova, Anthony M.

    2011-12-01

    In component-based modeling, a complex system is represented as a series of loosely integrated components with defined interfaces and data exchanges that allow the components to be coupled together through shared boundary conditions. Although the component-based paradigm is commonly used in software engineering, it has only recently been applied for modeling hydrologic and earth systems. As a result, research is needed to test and verify the applicability of the approach for modeling hydrologic systems. The objective of this work was therefore to investigate two aspects of using component-based software architecture for hydrologic modeling: (1) simulation of feedback loops between components that share a boundary condition and (2) data transfers between temporally misaligned model components. We investigated these topics using a simple case study where diffusion of mass is modeled across a water-sediment interface. We simulated the multimedia system using two model components, one for the water and one for the sediment, coupled using the Open Modeling Interface (OpenMI) standard. The results were compared with a more conventional numerical approach for solving the system where the domain is represented by a single multidimensional array. Results showed that the component-based approach was able to produce the same results obtained with the more conventional numerical approach. When the two components were temporally misaligned, we explored the use of different interpolation schemes to minimize mass balance error within the coupled system. The outcome of this work provides evidence that component-based modeling can be used to simulate complicated feedback loops between systems and guidance as to how different interpolation schemes minimize mass balance error introduced when components are temporally misaligned.

  18. Leveraging Existing Mission Tools in a Re-Usable, Component-Based Software Environment

    Science.gov (United States)

    Greene, Kevin; Grenander, Sven; Kurien, James; z,s (fshir. z[orttr); z,scer; O'Reilly, Taifun

    2006-01-01

    Emerging methods in component-based software development offer significant advantages but may seem incompatible with existing mission operations applications. In this paper we relate our positive experiences integrating existing mission applications into component-based tools we are delivering to three missions. In most operations environments, a number of software applications have been integrated together to form the mission operations software. In contrast, with component-based software development chunks of related functionality and data structures, referred to as components, can be individually delivered, integrated and re-used. With the advent of powerful tools for managing component-based development, complex software systems can potentially see significant benefits in ease of integration, testability and reusability from these techniques. These benefits motivate us to ask how component-based development techniques can be relevant in a mission operations environment, where there is significant investment in software tools that are not component-based and may not be written in languages for which component-based tools even exist. Trusted and complex software tools for sequencing, validation, navigation, and other vital functions cannot simply be re-written or abandoned in order to gain the advantages offered by emerging component-based software techniques. Thus some middle ground must be found. We have faced exactly this issue, and have found several solutions. Ensemble is an open platform for development, integration, and deployment of mission operations software that we are developing. Ensemble itself is an extension of an open source, component-based software development platform called Eclipse. Due to the advantages of component-based development, we have been able to vary rapidly develop mission operations tools for three surface missions by mixing and matching from a common set of mission operation components. We have also had to determine how to

  19. Simultaneous Distillation Extraction of Some Volatile Flavor Components from Pu-erh Tea Samples—Comparison with Steam Distillation-Liquid/Liquid Extraction and Soxhlet Extraction

    Science.gov (United States)

    Gu, Xungang; Zhang, Zhengzhu; Wan, Xiaochun; Ning, Jingming; Yao, Chengcheng; Shao, Wanfang

    2009-01-01

    A simutaneous distillation extraction (SDE) combined GC method was constructed for determination of volatile flavor components in Pu-erh tea samples. Dichloromethane and ethyl decylate was employed as organic phase in SDE and internal standard in determination, respectively. Weakly polar DB-5 column was used to separate the volatile flavor components in GC, 10 of the components were quantitatively analyzed, and further confirmed by GC-MS. The recovery covered from 66.4%–109%, and repeatability expressed as RSD was in range of 1.44%–12.6%. SDE was most suitable for the extraction of the anlytes by comparing with steam distillation-liquid/liquid extraction and Soxhlet extraction. Commercially available Pu-erh tea samples, including Pu-erh raw tea and ripe tea, were analyzed by the constructed method. the high-volatile components, such as benzyl alcohol, linalool oxide, and linalool, were greatly rich in Pu-erh raw teas, while the contents of 1,2,3-Trimethoxylbenzene and 1,2,4-Trimethoxylbenzene were much high in Pu-erh ripe teas. PMID:20169174

  20. Simultaneous Distillation Extraction of Some Volatile Flavor Components from Pu-erh Tea Samples-Comparison with Steam Distillation-Liquid/Liquid Extraction and Soxhlet Extraction.

    Science.gov (United States)

    Gu, Xungang; Zhang, Zhengzhu; Wan, Xiaochun; Ning, Jingming; Yao, Chengcheng; Shao, Wanfang

    2009-01-01

    A simutaneous distillation extraction (SDE) combined GC method was constructed for determination of volatile flavor components in Pu-erh tea samples. Dichloromethane and ethyl decylate was employed as organic phase in SDE and internal standard in determination, respectively. Weakly polar DB-5 column was used to separate the volatile flavor components in GC, 10 of the components were quantitatively analyzed, and further confirmed by GC-MS. The recovery covered from 66.4%-109%, and repeatability expressed as RSD was in range of 1.44%-12.6%. SDE was most suitable for the extraction of the anlytes by comparing with steam distillation-liquid/liquid extraction and Soxhlet extraction. Commercially available Pu-erh tea samples, including Pu-erh raw tea and ripe tea, were analyzed by the constructed method. the high-volatile components, such as benzyl alcohol, linalool oxide, and linalool, were greatly rich in Pu-erh raw teas, while the contents of 1,2,3-Trimethoxylbenzene and 1,2,4-Trimethoxylbenzene were much high in Pu-erh ripe teas.

  1. Simple and rapid simultaneous profiling of minor components of honey by size exclusion chromatography (SEC) coupled to ultraviolet diode array detection (UV-DAD), combined with chemometric methods.

    Science.gov (United States)

    Beretta, Giangiacomo; Fermo, Paola; Maffei Facino, Roberto

    2012-01-25

    This paper discusses the importance of profiling UV-responsive components, properly integrated with chemometric techniques, in detecting indicative parameters for quality control of honey. The minor components in honeys of different botanical and geographical origins were investigated by size SEC-UV-DAD. We diluted honey with mobile phase before injection into the chromatographic apparatus and a single chromatographic run gave a fast profile of high- (proteins and enzymes), intermediate- (e.g. terpenoid glycosides in lime tree honey) and low-molecular-weight components (secondary metabolites, e.g. kynurenic acid in chestnut honey). The analysis of a total number of 32 honey samples from different regions (Italy, Western Balkan countries, Brazil, Cameroon, Kenya) and of different botanical origins (herbal flower and arboreal flower nectars/honeydews) showed peculiar and characteristic distribution of these markers, which were basically related to their floral origin. Chemometric examination carried out using principal component analysis (PCA) and hierarchical cluster analysis (HCA) of the chromatograms (RT vs. absorption) detected four main clusters in which the groups of (i) chestnut honeys, (ii) honeys from rain forests and (iii) counterfeit/adulterated honeys were clearly separated from the main group of flower nectar honeys. The method is fast, requiring minimal sample handling, and the chromatographic data can be analyzed by multivariate statistical techniques to obtain descriptive information about the honey's quality and composition. Copyright © 2011 Elsevier B.V. All rights reserved.

  2. An integrated architecture analysis framework for component-based software development

    OpenAIRE

    Admodisastro, Novia

    2011-01-01

    The importance of architecture in reuse-driven development is widely recognized. Architecture provides a framework for establishing a match between available components and the system context. It is a key part of the system documentation; enforces the integrity of component composition and provides a basis for managing change. However, one of the most difficult problems in component-based system development (CBD) is ensuring that the software architecture provides an acceptable match with its...

  3. Using problem-based learning in web-based components of nurse education.

    Science.gov (United States)

    Crawford, Tonia R

    2011-03-01

    Problem-based learning (PBL) is a student-centred method of teaching, and is initiated by introducing a clinical problem through which learning is fostered by active inquisition (Tavakol and Reicherter, 2003). Using this teaching and learning strategy for web-based environments is examined from the literature for potential implementation in a Bachelor of Nursing program. In view of the evidence, students accessing online nursing subjects would seem to benefit from web-based PBL as it provides flexibility, opportunities for discussion and co-participation, encourages student autonomy, and allows construction of meaning as the problems mirror the real world. PBL also promotes critical thinking and transfer of theory to practice. It is recommended that some components of practice-based subjects such as Clinical Practice or Community Health Nursing, could be implemented online using a PBL format, which should also include a discussion forum to enable group work for problem-solving activities, and tutor facilitation. Copyright © 2010 Elsevier Ltd. All rights reserved.

  4. Simultaneous quantitative detection of multiple tumor markers with a rapid and sensitive multicolor quantum dots based immunochromatographic test strip.

    Science.gov (United States)

    Wang, Chunying; Hou, Fei; Ma, Yicai

    2015-06-15

    A novel multicolor quantum dots (QDs) based immunochromatographic test strip (ICTS) was developed for simultaneous quantitative detection of multiple tumor markers, by utilizing alpha fetoprotein (AFP) and carcinoembryonic antigen (CEA) as models. The immunosensor could realize simultaneous quantitative detection of tumor markers with only one test line and one control line on the nitrocellulose membrane (NC membrane) due to the introduction of multicolor QDs. In this method, a mixture of mouse anti-AFP McAb and mouse anti-CEA McAb was coated on NC membrane as test line and goat anti-mouse IgG antibody was coated as control line. Anti-AFP McAb-QDs546 conjugates and anti-CEA McAb-QDs620 conjugates were mixed and applied to the conjugate pad. Simultaneous quantitative detection of multiple tumor markers was achieved by detecting the fluorescence intensity of captured QDs labels on test line and control line using a test strip reader. Under the optimum conditions, AFP and CEA could be detected as low as 3 ng/mL and 2 ng/mL in 15 min with a sample volume of 80 μL, and no obvious cross-reactivity was observed. The immunosensor was validated with 130 clinical samples and in which it exhibited high sensitivity (93% for AFP and 87% for CEA) and specificity (94% for AFP and 97% for CEA). The immunosensor also demonstrated high recoveries (87.5-113% for AFP and 90-97.3% for CEA) and low relative standard deviations (RSDs) (2.8-6.2% for AFP and 4.9-9.6% for CEA) when testing spiked human serum. This novel multicolor QDs based ICTS provides an easy and rapid, simultaneous quantitative detecting strategy for point-of-care testing of tumor markers. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. Comprehensive management of the access to a component-based healthcare information system.

    Science.gov (United States)

    Lovis, Christian; Spahni, Stéphane; Cassoni-Schoellhammer, Nicolas; Geissbuhler, Antoine

    2006-01-01

    to describe the key concepts and elements used to implement a comprehensive access management system to a distributed, component-based healthcare information system. the a priori access is based on an institution-wide policy for access rights coupled to proximity process for the granting of such rights. Access rights are explicit and externalized from the information systems components. A posteriori control is based on a centralized, exhaustive journal of accesses to all components coupled to a decentralized verification process for suspicious accesses. the system has been operational for three years, initially used for the access to the computerized patient record components, and now extending to all the components of the hospital information system. The same architecture will be used for the development of the trans-institutional community health information network.

  6. Methods of Si based ceramic components volatilization control in a gas turbine engine

    Science.gov (United States)

    Garcia-Crespo, Andres Jose; Delvaux, John; Dion Ouellet, Noemie

    2016-09-06

    A method of controlling volatilization of silicon based components in a gas turbine engine includes measuring, estimating and/or predicting a variable related to operation of the gas turbine engine; correlating the variable to determine an amount of silicon to control volatilization of the silicon based components in the gas turbine engine; and injecting silicon into the gas turbine engine to control volatilization of the silicon based components. A gas turbine with a compressor, combustion system, turbine section and silicon injection system may be controlled by a controller that implements the control method.

  7. A Study on Components of Internal Control-Based Administrative System in Secondary Schools

    Science.gov (United States)

    Montri, Paitoon; Sirisuth, Chaiyuth; Lammana, Preeda

    2015-01-01

    The aim of this study was to study the components of the internal control-based administrative system in secondary schools, and make a Confirmatory Factor Analysis (CFA) to confirm the goodness of fit of empirical data and component model that resulted from the CFA. The study consisted of three steps: 1) studying of principles, ideas, and theories…

  8. Characterization of metal powder based rapid prototyping components under aluminium high pressure die casting process conditions

    CSIR Research Space (South Africa)

    Pereira, MFVT

    2009-11-01

    Full Text Available This paper is based on tests performed on die component specimens grown on an EOS RP technology platform, as well as manufactured specimens machined out of preferred standard hot work steel DIN 1.2344. These specimens resemble typical components...

  9. A Service Component-based Accounting and Charging Architecture to Support Interim Mechanisms across Multiple Domains

    NARCIS (Netherlands)

    Le, V.M.; van Beijnum, Bernhard J.F.; Huitema, G.B.

    Today, telematics services are o Aen compositions of different chargeable service components offered by different service providers. To enhance component-based accounting and charging, the service composition information is used to match with the corresponding charging structure of a service

  10. Prediction of Pure Component Adsorption Equilibria Using an Adsorption Isotherm Equation Based on Vacancy Solution Theory

    DEFF Research Database (Denmark)

    Marcussen, Lis; Aasberg-Petersen, K.; Krøll, Annette Elisabeth

    2000-01-01

    An adsorption isotherm equation for nonideal pure component adsorption based on vacancy solution theory and the Non-Random-Two-Liquid (NRTL) equation is found to be useful for predicting pure component adsorption equilibria at a variety of conditions. The isotherm equation is evaluated successfully...... adsorption systems, spreading pressure and isosteric heat of adsorption are also calculated....

  11. Simultaneous optimization of spin fluctuations and superconductivity under pressure in an iron-based superconductor.

    Science.gov (United States)

    Ji, G F; Zhang, J S; Ma, Long; Fan, P; Wang, P S; Dai, J; Tan, G T; Song, Y; Zhang, C L; Dai, Pengcheng; Normand, B; Yu, Weiqiang

    2013-09-06

    We present a high-pressure NMR study of the overdoped iron pnictide superconductor NaFe0.94Co0.06As. The low-energy antiferromagnetic spin fluctuations in the normal state, manifest as the Curie-Weiss upturn in the spin-lattice relaxation rate 1/(75)T1T, first increase strongly with pressure but fall again at P>Popt=2.2  GPa. Neither long-ranged magnetic order nor a structural phase transition is encountered up to 2.5 GPa. The superconducting transition temperature Tc shows a pressure dependence identical to the spin fluctuations. Our observations demonstrate that magnetic correlations and superconductivity are optimized simultaneously as a function of the electronic structure, thereby supporting very strongly a magnetic origin of superconductivity.

  12. A Model-Based Methodology for Simultaneous Design and Control of a Bioethanol Production Process

    DEFF Research Database (Denmark)

    Alvarado-Morales, Merlin; Abd.Hamid, Mohd-Kamaruddin; Sin, Gürkan

    2010-01-01

    In this work, a framework for the simultaneous solution of design and control problems is presented. Within this framework, two methodologies are presented, the integrated process design and controller design (IPDC) methodology and the process-group contribution (PGC) methodology. The concepts...... of attainable region (AR), driving force (DF), process-group (PG) and reverse simulation are used within these methodologies. The IPDC methodology is used to find the optimal design-control strategy of a process by locating the maximum point in the AR and DF diagrams for reactor and separator, respectively....... The PGC methodology is used to generate more efficient separation designs in terms of energy consumption by targeting the separation task at the largest DF. Both methodologies are highlighted through the application of two case studies, a bioethanol production process and a succinic acid production...

  13. Crosstalk Study of Simultaneous Wireless Power/Information Transmission Based on an LCC Compensation Network

    Directory of Open Access Journals (Sweden)

    Li Ji

    2017-10-01

    Full Text Available The effective simultaneous wireless transmission of power and information (SWTPI is an issue of great interest. To reduce the crosstalk between power and information channels while increasing the transmission air gap and power level, we introduce an inductor–capacitor–capacitor (LCC compensation network for an SWTPI system. First, the crosstalk between the power and information channels is analyzed. An effective parametric design method is then proposed for the LCC compensation network, which is analyzed theoretically to minimize the crosstalk. Finally, experiments are conducted at 1000 W and 115.2 kbps with an air gap of 100 cm to verify whether the proposed structure and design method of the LCC compensation network are suitable for the SWTPI.

  14. Stress corrosion cracking of Ni-based alloys in PWR primary water. Component surface control

    International Nuclear Information System (INIS)

    Foucault, M.

    2004-01-01

    In the PWR plant primary circuit, FRAMATOME-ANP uses several nickel-base alloys or austenitic stainless steels for the manufacture of safety components. The experience feedback of the last twenty years allows us to point out the major role played by the surface state of the components in their life duration. In this paper, we present two examples of problems encountered and solved by a surface study and the definition and implementation of a process for the surface control of the repair components. Then, we propose some ideas about the present needs in terms of analysis methods to improve the surface knowledge and the control of the manufactured components. (author)

  15. Simultaneous Determination and Pharmacokinetic Study of Six Components in Rat Plasma by HPLC-MS/MS after Oral Administration of Acanthopanax sessiliflorus Fruit Extract

    Directory of Open Access Journals (Sweden)

    Peng Du

    2016-12-01

    Full Text Available A specific and reliable HPLC-MS/MS method was developed and validated for the simultaneous determination of protocatechuic acid (PCA, scopolin, (−-pinoresinol-4,4′-di-O-β-d-glucopyranoside (PDG, acanthoside D, acanthoside B and hyperin in rat plasma for the first time. The analytes were separated on a C18 column (50 × 2.1 mm, 1.8 µm and a triple-quadrupole mass spectrometer equipped with an electrospray ionization (ESI source was used for detection. The rat plasma sample was prepared using the protein precipitation procedure. The calibration curves were linear over a concentration range of 1.2–1200.0 ng/mL for PCA, 0.96–960.0 ng/mL for scopolin, 1.12–1120.0 ng/mL for PDG, 1.32–1320.0 ng/mL for acanthoside D, 0.99–990.0 ng/mL for acanthoside B and 1.01–1010.0 ng/mL for hyperin. The intra-day and inter-day precision was less than 11.4% and the relative error (RE was all within ±15%. The validated method was successfully applied to assess the pharmacokinetics characteristics after the extracts of Acanthopanax sessiliflorus fruits were orally administered to the Sprague-Dawley rat.

  16. Dual Immunomagnetic Nanobeads-Based Lateral Flow Test Strip for Simultaneous Quantitative Detection of Carcinoembryonic Antigen and Neuron Specific Enolase

    Science.gov (United States)

    Lu, Wenting; Wang, Kan; Xiao, Kun; Qin, Weijian; Hou, Yafei; Xu, Hao; Yan, Xinyu; Chen, Yanrong; Cui, Daxiang; He, Jinghua

    2017-01-01

    A novel immunomagnetic nanobeads -based lateral flow test strip was developed for the simultaneous quantitative detection of neuron specific enolase (NSE) and carcinoembryonic antigen (CEA), which are sensitive and specific in the clinical diagnosis of small cell lung cancer. Using this nanoscale method, high saturation magnetization, carboxyl-modified magnetic nanobeads were successfully synthesized. To obtain the immunomagnetic probes, a covalent bioconjugation of the magnetic nanobeads with the antibody of NSE and CEA was carried out. The detection area contained test line 1 and test line 2 which captured the immune complexes sensitively and formed sandwich complexes. In this assay, cross-reactivity results were negative and both NSE and CEA were detected simultaneously with no obvious influence on each other. The magnetic signal intensity of the nitrocellulose membrane was measured by a magnetic assay reader. For quantitative analysis, the calculated limit of detection was 0.094 ng/mL for NSE and 0.045 ng/mL for CEA. One hundred thirty clinical samples were used to validate the test strip which exhibited high sensitivity and specificity. This dual lateral flow test strip not only provided an easy, rapid, simultaneous quantitative detection strategy for NSE and CEA, but may also be valuable in automated and portable diagnostic applications. PMID:28186176

  17. Comparison of different extraction methods: steam distillation, simultaneous distillation and extraction and headspace co-distillation, used for the analysis of the volatile components in aged flue-cured tobacco leaves.

    Science.gov (United States)

    Peng, Fumin; Sheng, Liangquan; Liu, Baizhan; Tong, Hongwu; Liu, Shaomin

    2004-06-18

    Steam distillation (SD), simultaneous distillation and extraction (SDE) and headspace co-distillation (HCD) were compared here for their effectiveness in the extraction of volatile compounds from tobacco. The different grades of aged flue-cured tobacco leaves extracted by the three methods respectively were analyzed using GC-MS. Mass spectra or authentic compounds were used to identify around 408 components in various volatile fractions. On the one hand, the qualitative comparison showed that more compounds were detected in HCD extract (391 components) than in SDE extract (377 components), and the approximately quantitative analysis showed that the total amount of volatile components in SDE extract (445.48 microg/g) was much more than that in HCD extract (315.72 microg/g). But on the other hand, HCD was the most efficient for nearly all the highly volatile compounds among the three methods. As to low-volatile compounds such as lactones, long chain aldehydes, ketones, alcohols, and esters, more was detected in SDE extract than in HCD extract. The SD method (322 components, total amount 228.42 microg/g) was the lowest sensitive to all compounds except semi-volatile fatty acids among the three methods.

  18. Adding a Performance-Based Component to Surface Warfare Officer Bonuses: Will it Affect Retention?

    National Research Council Canada - National Science Library

    Carman, Aron S; Mudd, Ryan M

    2008-01-01

    ... Authorization and the current officer inventory beginning at 9 years of commissioned service. The objective of this study was to analyze the 13-year retention effect of adding a performance-based component to the SWO Critical Skills Bonus (CSB...

  19. Model-Based Design Tools for Extending COTS Components To Extreme Environments, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The innovation in this project is model-based design (MBD) tools for predicting the performance and useful life of commercial-off-the-shelf (COTS) components and...

  20. RF Front End Based on MEMS Components for Miniaturized Digital EVA Radio, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — In this SBIR project, AlphaSense, Inc. and the Carnegie Mellon University propose to develop a RF receiver front end based on CMOS-MEMS components for miniaturized...

  1. RF Front End Based on MEMS Components for Miniaturized Digital EVA Radio, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — In this proposal, AlphaSense, Inc. (AI) and the Carnegie Mellon University (CMU) detail the development of RF front end based on MEMS components for miniaturized...

  2. Uniframe: A Unified Framework for Developing Service-Oriented, Component-Based Distributed Software Systems

    National Research Council Canada - National Science Library

    Raje, Rajeev R; Olson, Andrew M; Bryant, Barrett R; Burt, Carol C; Auguston, Makhail

    2005-01-01

    .... It describes how this approach employs a unifying framework for specifying such systems to unite the concepts of service-oriented architectures, a component-based software engineering methodology...

  3. Safety prediction for basic components of safety-critical software based on static testing

    International Nuclear Information System (INIS)

    Son, H.S.; Seong, P.H.

    2000-01-01

    The purpose of this work is to develop a safety prediction method, with which we can predict the risk of software components based on static testing results at the early development stage. The predictive model combines the major factor with the quality factor for the components, which are calculated based on the measures proposed in this work. The application to a safety-critical software system demonstrates the feasibility of the safety prediction method. (authors)

  4. A Component-based Software Development and Execution Framework for CAx Applications

    Directory of Open Access Journals (Sweden)

    N. Matsuki

    2004-01-01

    Full Text Available Digitalization of the manufacturing process and technologies is regarded as the key to increased competitive ability. The MZ-Platform infrastructure is a component-based software development framework, designed for supporting enterprises to enhance digitalized technologies using software tools and CAx components in a self-innovative way. In the paper we show the algorithm, system architecture, and a CAx application example on MZ-Platform. We also propose a new parametric data structure based on MZ-Platform.

  5. Safety prediction for basic components of safety critical software based on static testing

    International Nuclear Information System (INIS)

    Son, H.S.; Seong, P.H.

    2001-01-01

    The purpose of this work is to develop a safety prediction method, with which we can predict the risk of software components based on static testing results at the early development stage. The predictive model combines the major factor with the quality factor for the components, both of which are calculated based on the measures proposed in this work. The application to a safety-critical software system demonstrates the feasibility of the safety prediction method. (authors)

  6. Simultaneous construction of PCR-DGGE-based predictive models of Listeria monocytogenes and Vibrio parahaemolyticus on cooked shrimps.

    Science.gov (United States)

    Liao, C; Peng, Z Y; Li, J B; Cui, X W; Zhang, Z H; Malakar, P K; Zhang, W J; Pan, Y J; Zhao, Y

    2015-03-01

    The aim of this study was to simultaneously construct PCR-DGGE-based predictive models of Listeria monocytogenes and Vibrio parahaemolyticus on cooked shrimps at 4 and 10°C. Calibration curves were established to correlate peak density of DGGE bands with microbial counts. Microbial counts derived from PCR-DGGE and plate methods were fitted by Baranyi model to obtain molecular and traditional predictive models. For L. monocytogenes, growing at 4 and 10°C, molecular predictive models were constructed. It showed good evaluations of correlation coefficients (R(2) > 0.92), bias factors (Bf ) and accuracy factors (Af ) (1.0 ≤ Bf ≤ Af ≤ 1.1). Moreover, no significant difference was found between molecular and traditional predictive models when analysed on lag phase (λ), maximum growth rate (μmax ) and growth data (P > 0.05). But for V. parahaemolyticus, inactivated at 4 and 10°C, molecular models show significant difference when compared with traditional models. Taken together, these results suggest that PCR-DGGE based on DNA can be used to construct growth models, but it is inappropriate for inactivation models yet. This is the first report of developing PCR-DGGE to simultaneously construct multiple molecular models. It has been known for a long time that microbial predictive models based on traditional plate methods are time-consuming and labour-intensive. Denaturing gradient gel electrophoresis (DGGE) has been widely used as a semiquantitative method to describe complex microbial community. In our study, we developed DGGE to quantify bacterial counts and simultaneously established two molecular predictive models to describe the growth and survival of two bacteria (Listeria monocytogenes and Vibrio parahaemolyticus) at 4 and 10°C. We demonstrated that PCR-DGGE could be used to construct growth models. This work provides a new approach to construct molecular predictive models and thereby facilitates predictive microbiology and QMRA (Quantitative Microbial

  7. Study on Low Illumination Simultaneous Polarization Image Registration Based on Improved SURF Algorithm

    Science.gov (United States)

    Zhang, Wanjun; Yang, Xu

    2017-12-01

    Registration of simultaneous polarization images is the premise of subsequent image fusion operations. However, in the process of shooting all-weather, the polarized camera exposure time need to be kept unchanged, sometimes polarization images under low illumination conditions due to too dark result in SURF algorithm can not extract feature points, thus unable to complete the registration, therefore this paper proposes an improved SURF algorithm. Firstly, the luminance operator is used to improve overall brightness of low illumination image, and then create integral image, using Hession matrix to extract the points of interest to get the main direction of characteristic points, calculate Haar wavelet response in X and Y directions to get the SURF descriptor information, then use the RANSAC function to make precise matching, the function can eliminate wrong matching points and improve accuracy rate. And finally resume the brightness of the polarized image after registration, the effect of the polarized image is not affected. Results show that the improved SURF algorithm can be applied well under low illumination conditions.

  8. MCM-based microlaboratory for simultaneous measurement of several biochemical parameters by spectrophotometry.

    Science.gov (United States)

    Minas, Graca; Wolffenbuttel, Reinoud F; Correia, Jose H

    2010-08-01

    This paper reports on the concept, fabrication and characterization of a multi-chip module microlaboratory. The application is in the spectrophotometric analysis of human physiological fluids in a clinical setting. The system is composed of three stacked parts: (1) a central microfluidic system die containing the microchannels, which is fabricated by applying MEMS techniques to an SU-8 layer, (2) an optical filtering system on the top side, fabricated using a dielectric thin-films multilayer and (3) a detection and readout system on the bottom side, which is fabricated in a CMOS microelectronic process. The system modularity and emphasis on microfabrication provides potential for low unit cost. The application is the simultaneous and quantitative measurement of the concentration of four biochemical parameters in human physiological fluids by spectrally selective optical absorption. The intensity of the light transmitted through the physiological fluid results in an electrical output signal in the form of bit streams, which allows simple computer interfacing. A simple white light source is used for illumination, due to the optical filtering system, which makes the microlaboratory portable. The quantitative measurement of chloride, creatinine, total protein and uric acid in urine is successfully demonstrated.

  9. Analysis of rice policy based on presidential instruction on household food security: simultaneous equation model

    Science.gov (United States)

    Sembiring, S. A.

    2018-02-01

    The objective of this research is to analyze the impacts of rice policy on the household food security. The research used cross section data, were collected from 74 respondent as determined by purposive sampling in Sei Rejo villages, the Sub District of Sei Rampah, Serdang Bedagai District in the Province of North Sumatera. Rice policy model specification uses the simultaneous equations consisting of 6 structural equations and 6 identity equations which was estimated using Two Stages Least Squares (2SLS) method. The results show that the effectiveness of government purchase price of dried harvest paddy gave a positive impact on paddy planted area and lead to an increase paddy production and an increase of the rice production gave a positive impact on household rice availability and household rice surplus, and the increase of household rice surplus gave the quantity of Raskin decrease, whereas the increase of fertilizers gave a negative impact on paddy planted area and lead to decrease paddy production and to decrease in rice production was followed by an decrease in household rice availability and household rice surplus, and the decrease of household rice surplus gave the quantity of Raskin increase.

  10. Single wearable sensing energy device based on photoelectric biofuel cells for simultaneous analysis of perspiration and illuminance.

    Science.gov (United States)

    Yu, You; Zhai, Junfeng; Xia, Yong; Dong, Shaojun

    2017-08-24

    Wearable electronics are essential for the construction of epidermal energy supply and portable healthcare devices. Herein, a self-powered wearable electronic device based on a photoelectric biofuel cell has been introduced for the first time to simultaneously detect the perspiration lactate and monitor the ambient illuminance depending on independent parameters. The functions of harvesting energy, detection of body function and monitoring of ambient have been merged into a single wireless sensor. This novel design may provide a wide range of smart and exciting wearable electronics.

  11. EMG-Based Continuous and Simultaneous Estimation of Arm Kinematics in Able-Bodied Individuals and Stroke Survivors

    Directory of Open Access Journals (Sweden)

    Jie Liu

    2017-08-01

    Full Text Available Among the potential biological signals for human-machine interactions (brain, nerve, and muscle signals, electromyography (EMG widely used in clinical setting can be obtained non-invasively as motor commands to control movements. The aim of this study was to develop a model for continuous and simultaneous decoding of multi-joint dynamic arm movements based on multi-channel surface EMG signals crossing the joints, leading to application of myoelectrically controlled exoskeleton robots for upper-limb rehabilitation. Twenty subjects were recruited for this study including 10 stroke subjects and 10 able-bodied subjects. The subjects performed free arm reaching movements in the horizontal plane with an exoskeleton robot. The shoulder, elbow and wrist movements and surface EMG signals from six muscles crossing the three joints were recorded. A non-linear autoregressive exogenous (NARX model was developed to continuously decode the shoulder, elbow and wrist movements based solely on the EMG signals. The shoulder, elbow and wrist movements were decoded accurately based only on the EMG inputs in all the subjects, with the variance accounted for (VAF > 98% for all three joints. The proposed approach is capable of simultaneously and continuously decoding multi-joint movements of the human arm by taking into account the non-linear mappings between the muscle EMGs and joint movements, which may provide less effortful control of robotic exoskeletons for rehabilitation training of individuals with neurological disorders and arm impairment.

  12. EMG-Based Continuous and Simultaneous Estimation of Arm Kinematics in Able-Bodied Individuals and Stroke Survivors

    Science.gov (United States)

    Liu, Jie; Kang, Sang Hoon; Xu, Dali; Ren, Yupeng; Lee, Song Joo; Zhang, Li-Qun

    2017-01-01

    Among the potential biological signals for human-machine interactions (brain, nerve, and muscle signals), electromyography (EMG) widely used in clinical setting can be obtained non-invasively as motor commands to control movements. The aim of this study was to develop a model for continuous and simultaneous decoding of multi-joint dynamic arm movements based on multi-channel surface EMG signals crossing the joints, leading to application of myoelectrically controlled exoskeleton robots for upper-limb rehabilitation. Twenty subjects were recruited for this study including 10 stroke subjects and 10 able-bodied subjects. The subjects performed free arm reaching movements in the horizontal plane with an exoskeleton robot. The shoulder, elbow and wrist movements and surface EMG signals from six muscles crossing the three joints were recorded. A non-linear autoregressive exogenous (NARX) model was developed to continuously decode the shoulder, elbow and wrist movements based solely on the EMG signals. The shoulder, elbow and wrist movements were decoded accurately based only on the EMG inputs in all the subjects, with the variance accounted for (VAF) > 98% for all three joints. The proposed approach is capable of simultaneously and continuously decoding multi-joint movements of the human arm by taking into account the non-linear mappings between the muscle EMGs and joint movements, which may provide less effortful control of robotic exoskeletons for rehabilitation training of individuals with neurological disorders and arm impairment. PMID:28890685

  13. Textile-Based Electronic Components for Energy Applications: Principles, Problems, and Perspective

    Directory of Open Access Journals (Sweden)

    Vishakha Kaushik

    2015-09-01

    Full Text Available Textile-based electronic components have gained interest in the fields of science and technology. Recent developments in nanotechnology have enabled the integration of electronic components into textiles while retaining desirable characteristics such as flexibility, strength, and conductivity. Various materials were investigated in detail to obtain current conductive textile technology, and the integration of electronic components into these textiles shows great promise for common everyday applications. The harvest and storage of energy in textile electronics is a challenge that requires further attention in order to enable complete adoption of this technology in practical implementations. This review focuses on the various conductive textiles, their methods of preparation, and textile-based electronic components. We also focus on fabrication and the function of textile-based energy harvesting and storage devices, discuss their fundamental limitations, and suggest new areas of study.

  14. Designing Fault Tolerance Strategy by Iterative Redundancy for Component-Based Distributed Computing Systems

    Directory of Open Access Journals (Sweden)

    Hui Wang

    2014-01-01

    Full Text Available Reliability is a critical issue for component-based distributed computing systems, some distributed software allows the existence of large numbers of potentially faulty components on an open network. Faults are inevitable in this large-scale, complex, distributed components setting, which may include a lot of untrustworthy parts. How to provide highly reliable component-based distributed systems is a challenging problem and a critical research. Generally, redundancy and replication are utilized to realize the goal of fault tolerance. In this paper, we propose a CFI (critical fault iterative redundancy technique, by which the efficiency can be guaranteed to make use of resources (e.g., computation and storage and to create fault-tolerance applications. When operating in an environment with unknown components’ reliability, CFI redundancy is more efficient and adaptive than other techniques (e.g., K-Modular Redundancy and N-Version Programming. In the CFI strategy of redundancy, the function invocation relationships and invocation frequencies are employed to rank the functions’ importance and identify the most vulnerable function implemented via functionally equivalent components. A tradeoff has to be made between efficiency and reliability. In this paper, a formal theoretical analysis and an experimental analysis are presented. Compared with the existing methods, the reliability of components-based distributed system can be greatly improved by tolerating a small part of significant components.

  15. Detection of arc fault based on frequency constrained independent component analysis

    Science.gov (United States)

    Yang, Kai; Zhang, Rencheng; Xu, Renhao; Chen, Yongzhi; Yang, Jianhong; Chen, Shouhong

    2015-02-01

    Arc fault is one of the main reasons of electrical fires. As a result of weakness, randomness and cross talk of arc faults, very few of methods have been successfully used to protect loads from all arc faults in low-voltage circuits. Therefore, a novel detection method is developed for detection of arc faults. The method is based on frequency constrained independent component analysis. In the process of the method derivation, a band-pass filter was introduced as a constraint condition to separate independent components of mixed signals. In the process of the independent component separations, although the fault mixed signals were under the conditions of the strong background noise and the frequency aliasing, the effective high frequency components of arc faults could be separated by frequency constrained independent component analysis. Based on the separated components, the power spectrums of them were calculated to classify the normal and the arc fault conditions. The validity of the developed method was verified by using an arc fault experimental platform set up. The results show that arc faults of nine typical electrical loads are successfully detected based on frequency constrained independent component analysis.

  16. Simultaneous determination of ascorbic acid, dopamine and uric acid based on tryptophan functionalized graphene

    Energy Technology Data Exchange (ETDEWEB)

    Lian, Qianwen; He, Zhifang; He, Qian; Luo, Ai; Yan, Kaiwang; Zhang, Dongxia [Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Geography and Environment Science, Northwest Normal University, Lanzhou, 730070 (China); Lu, Xiaoquan, E-mail: Luxq@nwnu.edu.cn [Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070 (China); Zhou, Xibin, E-mail: zhouxb@nwnu.edu.cn [Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Geography and Environment Science, Northwest Normal University, Lanzhou, 730070 (China)

    2014-05-01

    Highlights: • Trp-GR was synthesized by utilizing a facile ultrasonic method. • The material as prepared had well dispersivity in water and better conductivity than pure GR. • Trp-GR/GCE showed excellent potential for the determination of AA, DA and UA. • The proposed method was applied for the analysis of AA, DA and UA in real samples. - Abstract: A new type of tryptophan-functionalized graphene nanocomposite (Trp-GR) was synthesized by utilizing a facile ultrasonic method via π–π conjugate action between graphene (GR) and tryptophan (Trp) molecule. The material as prepared had well dispersivity in water and better conductivity than pure GR. The surface morphology of Trp-GR was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Raman spectroscopy. The electrochemical behaviors of ascorbic acid (AA), dopamine (DA), and uric acid (UA) were investigated by cyclic voltammetry (CV) on the surface of Trp-GR. The separation of the oxidation peak potentials for AA–DA, DA–UA and UA–AA was about 182 mV, 125 mV and 307 mV, which allowed simultaneously determining AA, DA, and UA. Differential pulse voltammetery (DPV) was used for the determination of AA, DA, and UA in their mixture. Under optimum conditions, the linear response ranges for the determination of AA, DA, and UA were 0.2–12.9 mM, 0.5–110 μM, and 10–1000 μM, with the detection limits (S/N = 3) of 10.09 μM, 0.29 μM and 1.24 μM, respectively. Furthermore, the modified electrode was investigated for real sample analysis.

  17. Cross-talk-free simultaneous fluoroimmunoassay of two biomarkers based on dual-color quantum dots

    Energy Technology Data Exchange (ETDEWEB)

    Cao Zhijuan; Li Huan [School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (China); Lau Choiwan, E-mail: cyliu@shmu.edu.cn [School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (China); Zhang Yuhao, E-mail: zhang.yuhao@zs-hospital.sh.cn [Department of Neurology, Zhongshan Hospital, 180 Fenglin Road, Shanghai 200032 (China)

    2011-07-18

    Highlights: {yields} A new cross-talk-free duplex fluoroimmunoassay for cancer related biomarkers was developed using multiple QD as detection elements with the LOD of 0.625 ng/mL. {yields} A fast homogeneous immunoreaction as well as a simple heterogeneous separation process was achieved by the coupling of the submicrometer-sized polystyrene microspheres as the carrier and the 96-well filter plate as the reaction and separation container. {yields} This new approach could also be extended to detect other biomarkers relating to other cancers, such as alpha fetoprotein and prostate specific antigen associated with liver cancer and prostrate cancer, etc. - Abstract: In this article, we demonstrate the fabrication and simultaneous fluorescent detection of two biomarkers related to lung cancer. Polystyrene microspheres (PSM) were introduced as biomolecular immobilizing carriers and a 96-well filter plate was used as the separation platform. The whole experiment could be effectively carried out in a homogeneous system, as exemplified by the detection of carcinoembryonic antigen (CEA) and neuron specific enolase (NSE). First, two capture antibodies for CEA and NSE were immobilized on the PSM surface. Next, they reacted successively with two antigens and two modified detection antibodies. Finally, these two biomarkers could be recognized by streptavidin-conjugated quantum dots (QD) and goat-anti-FITC conjugated QD with a detection limit of 0.625 ng mL{sup -1}, which was lower than the clinical cut-off level. The protocol showed good precision within 6.36% and good recovery in the range of 90.86-105.02%. Compared with several other assay formats reported previously, our new technique is competitive or even better. Furthermore, the immunosensor was successfully illustrated in 20 serum samples. Overall, this new immunoassay offers a promising alternative for the detection of biomarkers related to cancer diseases, taking advantage of simplicity, specificity, sensitivity and

  18. Exploring the Utility of Logistic Mixed Modeling Approaches to Simultaneously Investigate Item and Testlet DIF on Testlet-based Data.

    Science.gov (United States)

    Fukuhara, Hirotaka; Paek, Insu

    2016-01-01

    This study explored the utility of logistic mixed models for the analysis of differential item functioning when item response data were testlet-based. Decomposition of differential item functioning (DIF) into item level and testlet level for the testlet-based data was introduced to separate possible sources of DIF: (1) an item, (2) a testlet, and (3) both the item and the testlet. Simulation study was conducted to investigate the performance of several logistic mixed models as well as the Mantel-Haenszel method under the conditions, in which the item-related DIF and testlet-related DIF were present simultaneously. The results revealed that a new DIF model based on a logistic mixed model with random item effects and item covariates could capture the item-related DIF and testlet-related DIF well under certain conditions.

  19. Carbonate substitution in the mineral component of bone: Discriminating the structural changes, simultaneously imposed by carbonate in A and B sites of apatite

    Science.gov (United States)

    Madupalli, Honey; Pavan, Barbara; Tecklenburg, Mary M. J.

    2017-11-01

    The mineral component of bone and other biological calcifications is primarily a carbonate substituted calcium apatite. Integration of carbonate into two sites, substitution for phosphate (B-type carbonate) and substitution for hydroxide (A-type carbonate), influences the crystal properties which relate to the functional properties of bone. In the present work, a series of AB-type carbonated apatites (AB-CAp) having varying A-type and B-type carbonate weight fractions were prepared and analyzed by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (XRD), and carbonate analysis. A detailed characterization of A-site and B-site carbonate assignment in the FTIR ν3 region is proposed. The mass fractions of carbonate in A-site and B-site of AB-CAp correlate differently with crystal axis length and crystallite domain size. In this series of samples reduction in crystal domain size correlates only with A-type carbonate which indicates that carbonate in the A-site is more disruptive to the apatite structure than carbonate in the B-site. High temperature methods were required to produce significant A-type carbonation of apatite, indicating a higher energy barrier for the formation of A-type carbonate than for B-type carbonate. This is consistent with the dominance of B-type carbonate substitution in low temperature synthetic and biological apatites.

  20. High Temperature Corrosion Problem of Boiler Components in presence of Sulfur and Alkali based Fuels

    Science.gov (United States)

    Ghosh, Debashis; Mitra, Swapan Kumar

    2011-04-01

    Material degradation and ageing is of particular concern for fossil fuel fired power plant components. New techniques/approaches have been explored in recent years for Residual Life assessment of aged components and material degradation due to different damage mechanism like creep, fatigue, corrosion and erosion etc. Apart from the creep, the high temperature corrosion problem in a fossil fuel fired boiler is a matter of great concern if the fuel contains sulfur, chlorine sodium, potassium and vanadium etc. This paper discusses the material degradation due to high temperature corrosion in different critical components of boiler like water wall, superheater and reheater tubes and also remedial measures to avoid the premature failure. This paper also high lights the Residual Life Assessment (RLA) methodology of the components based on high temperature fireside corrosion. of different critical components of boiler.

  1. Principal component analysis of tomato genotypes based on some morphological and biochemical quality indicators

    Directory of Open Access Journals (Sweden)

    Glogovac Svetlana

    2012-01-01

    Full Text Available This study investigates variability of tomato genotypes based on morphological and biochemical fruit traits. Experimental material is a part of tomato genetic collection from Institute of Filed and Vegetable Crops in Novi Sad, Serbia. Genotypes were analyzed for fruit mass, locule number, index of fruit shape, fruit colour, dry matter content, total sugars, total acidity, lycopene and vitamin C. Minimum, maximum and average values and main indicators of variability (CV and σ were calculated. Principal component analysis was performed to determinate variability source structure. Four principal components, which contribute 93.75% of the total variability, were selected for analysis. The first principal component is defined by vitamin C, locule number and index of fruit shape. The second component is determined by dry matter content, and total acidity, the third by lycopene, fruit mass and fruit colour. Total sugars had the greatest part in the fourth component.

  2. Component alignment and functional outcome following computer assisted and jig based total knee arthroplasty.

    Science.gov (United States)

    Lad, Dnyanesh G; Thilak, Jai; Thadi, Mohan

    2013-01-01

    Incorrect positioning of the implant and improper alignment of the limb following total knee arthroplasty (TKA) can lead to rapid implant wear, loosening, and suboptimal function. Studies suggest that alignment errors of > 3° are associated with rapid failure and less satisfactory function. Computer navigated systems have been developed to enhance precision in instrumentation during surgery. The aim of the study was to compare component alignment following computer assisted surgery (CAS) and jig based TKA as well as functional outcome. This is a prospective study of 100 knees to compare computer-assisted TKA and jig-based surgery in relation to femoral and tibial component alignment and functional outcome. The postoperative x-rays (anteroposterior and lateral) of the knee and CT scanogram from hip to foot were obtained. The coronal alignment of the femoral and tibial components and rotational alignment of femoral component was calculated. Knee society score at 24 months was used to assess the function. Results of our study show that mean placement of the tibial component in coronal plane (91.3037°) and sagittal planes (3.6058°) was significantly better with CAS. The difference was statistically insignificant in case of mean coronal alignment of the femoral components (90.34210° in navigation group and 90.5444° in jig group) and in case of the mean femoral condylar twist angle (external rotation 2.3406° in navigation group versus 2.3593° in jig group). A significantly improved placement of the component was found in the coronal and sagittal planes of the tibial component by CAS. The placement of the components in the other planes was comparable with the values recorded in the jig-based surgery group. Functional outcome was not significantly different.

  3. Optimal condition-based maintenance decisions for systems with dependent stochastic degradation of components

    International Nuclear Information System (INIS)

    Hong, H.P.; Zhou, W.; Zhang, S.; Ye, W.

    2014-01-01

    Components in engineered systems are subjected to stochastic deterioration due to the operating environmental conditions, and the uncertainty in material properties. The components need to be inspected and possibly replaced based on preventive or failure replacement criteria to provide the intended and safe operation of the system. In the present study, we investigate the influence of dependent stochastic degradation of multiple components on the optimal maintenance decisions. We use copula to model the dependent stochastic degradation of components, and formulate the optimal decision problem based on the minimum expected cost rule and the stochastic dominance rules. The latter is used to cope with decision maker's risk attitude. We illustrate the developed probabilistic analysis approach and the influence of the dependency of the stochastic degradation on the preferred decisions through numerical examples

  4. Color Independent Components Based SIFT Descriptors for Object/Scene Classification

    Science.gov (United States)

    Ai, Dan-Ni; Han, Xian-Hua; Ruan, Xiang; Chen, Yen-Wei

    In this paper, we present a novel color independent components based SIFT descriptor (termed CIC-SIFT) for object/scene classification. We first learn an efficient color transformation matrix based on independent component analysis (ICA), which is adaptive to each category in a database. The ICA-based color transformation can enhance contrast between the objects and the background in an image. Then we compute CIC-SIFT descriptors over all three transformed color independent components. Since the ICA-based color transformation can boost the objects and suppress the background, the proposed CIC-SIFT can extract more effective and discriminative local features for object/scene classification. The comparison is performed among seven SIFT descriptors, and the experimental classification results show that our proposed CIC-SIFT is superior to other conventional SIFT descriptors.

  5. Predictive based monitoring of nuclear plant component degradation using support vector regression

    International Nuclear Information System (INIS)

    Agarwal, Vivek; Alamaniotis, Miltiadis; Tsoukalas, Lefteri H.

    2015-01-01

    Nuclear power plants (NPPs) are large installations comprised of many active and passive assets. Degradation monitoring of all these assets is expensive (labor cost) and highly demanding task. In this paper a framework based on Support Vector Regression (SVR) for online surveillance of critical parameter degradation of NPP components is proposed. In this case, on time replacement or maintenance of components will prevent potential plant malfunctions, and reduce the overall operational cost. In the current work, we apply SVR equipped with a Gaussian kernel function to monitor components. Monitoring includes the one-step-ahead prediction of the component's respective operational quantity using the SVR model, while the SVR model is trained using a set of previous recorded degradation histories of similar components. Predictive capability of the model is evaluated upon arrival of a sensor measurement, which is compared to the component failure threshold. A maintenance decision is based on a fuzzy inference system that utilizes three parameters: (i) prediction evaluation in the previous steps, (ii) predicted value of the current step, (iii) and difference of current predicted value with components failure thresholds. The proposed framework will be tested on turbine blade degradation data.

  6. Reliability Evaluation of Machine Center Components Based on Cascading Failure Analysis

    Science.gov (United States)

    Zhang, Ying-Zhi; Liu, Jin-Tong; Shen, Gui-Xiang; Long, Zhe; Sun, Shu-Guang

    2017-07-01

    In order to rectify the problems that the component reliability model exhibits deviation, and the evaluation result is low due to the overlook of failure propagation in traditional reliability evaluation of machine center components, a new reliability evaluation method based on cascading failure analysis and the failure influenced degree assessment is proposed. A direct graph model of cascading failure among components is established according to cascading failure mechanism analysis and graph theory. The failure influenced degrees of the system components are assessed by the adjacency matrix and its transposition, combined with the Pagerank algorithm. Based on the comprehensive failure probability function and total probability formula, the inherent failure probability function is determined to realize the reliability evaluation of the system components. Finally, the method is applied to a machine center, it shows the following: 1) The reliability evaluation values of the proposed method are at least 2.5% higher than those of the traditional method; 2) The difference between the comprehensive and inherent reliability of the system component presents a positive correlation with the failure influenced degree of the system component, which provides a theoretical basis for reliability allocation of machine center system.

  7. Verification of the Simultaneous Local Extraction Method of Base and Thermal Resistance of Bipolar Transistors

    OpenAIRE

    Robert Setekera; Luuk Tiemeijer; Ramses van der Toorn

    2014-01-01

    In this paper an extensive verification of the extraction method (published earlier) that consistently accounts for self-heating and Early effect to accurately extract both base and thermal resistance of bipolar junction transistors is presented. The method verification is demonstrated on advanced RF SiGe HBTs were the extracted results for the thermal resistance are compared with those from another published method that ignores the effect of Early effect on internal base...

  8. [Design of traditional Chinese medicines with antihypertensive components based on medicinal property combination modes].

    Science.gov (United States)

    Liao, Su-Fen; Yan, Su-Rong; Guo, Wei-Jia; Luo, Ji; Sun, Jing; Dong, Fang; Wang, Yun; Qiao, Yan-Jiang

    2014-07-01

    Multi-component traditional Chinese medicines are an innovative research mode for traditional Chinese medicines. Currently, there are many design methods for developing multi-component traditional Chinese medicines, but their common feature is the lack of effective connection of the traditional Chinese medicine theory. In this paper, the authors discussed the multi-component traditional Chinese medicine design methods based on medicinal property combination modes, provided the combination methods with the characteristics of traditional Chinese medicine for the prescription combinations, and proved its feasibly with hypertension cases.

  9. A classification method based on principal components of SELDI spectra to diagnose of lung adenocarcinoma.

    Directory of Open Access Journals (Sweden)

    Qiang Lin

    Full Text Available Lung cancer is the leading cause of cancer death worldwide, but techniques for effective early diagnosis are still lacking. Proteomics technology has been applied extensively to the study of the proteins involved in carcinogenesis. In this paper, a classification method was developed based on principal components of surface-enhanced laser desorption/ionization (SELDI spectral data. This method was applied to SELDI spectral data from 71 lung adenocarcinoma patients and 24 healthy individuals. Unlike other peak-selection-based methods, this method takes each spectrum as a unity. The aim of this paper was to demonstrate that this unity-based classification method is more robust and powerful as a method of diagnosis than peak-selection-based methods.The results showed that this classification method, which is based on principal components, has outstanding performance with respect to distinguishing lung adenocarcinoma patients from normal individuals. Through leaving-one-out, 19-fold, 5-fold and 2-fold cross-validation studies, we found that this classification method based on principal components completely outperforms peak-selection-based methods, such as decision tree, classification and regression tree, support vector machine, and linear discriminant analysis.The classification method based on principal components of SELDI spectral data is a robust and powerful means of diagnosing lung adenocarcinoma. We assert that the high efficiency of this classification method renders it feasible for large-scale clinical use.

  10. Component Evaluation of a Computer Based Format for Teaching Discrete Trial and Backward Chaining

    Science.gov (United States)

    Nosik, Melissa R.; Williams, W. Larry

    2011-01-01

    The effectiveness of a multi-component computer based training package that consisted of competency based instructions, video modeling, and two forms of feedback was evaluated in terms of treatment integrity of two procedures across four staff. Treatment integrity in completing critical steps of discrete-trial and backward chaining procedures were…

  11. Multi-Step Deep Reactive Ion Etching Fabrication Process for Silicon-Based Terahertz Components

    Science.gov (United States)

    Jung-Kubiak, Cecile (Inventor); Reck, Theodore (Inventor); Chattopadhyay, Goutam (Inventor); Perez, Jose Vicente Siles (Inventor); Lin, Robert H. (Inventor); Mehdi, Imran (Inventor); Lee, Choonsup (Inventor); Cooper, Ken B. (Inventor); Peralta, Alejandro (Inventor)

    2016-01-01

    A multi-step silicon etching process has been developed to fabricate silicon-based terahertz (THz) waveguide components. This technique provides precise dimensional control across multiple etch depths with batch processing capabilities. Nonlinear and passive components such as mixers and multipliers waveguides, hybrids, OMTs and twists have been fabricated and integrated into a small silicon package. This fabrication technique enables a wafer-stacking architecture to provide ultra-compact multi-pixel receiver front-ends in the THz range.

  12. Design of multi-tiered database application based on CORBA component

    International Nuclear Information System (INIS)

    Sun Xiaoying; Dai Zhimin

    2003-01-01

    As computer technology quickly developing, middleware technology changed traditional two-tier database system. The multi-tiered database system, consisting of client application program, application servers and database serves, is mainly applying. While building multi-tiered database system using CORBA component has become the mainstream technique. In this paper, an example of DUV-FEL database system is presented, and then discuss the realization of multi-tiered database based on CORBA component. (authors)

  13. Simultaneous estimation of cross-validation errors in least squares collocation applied for statistical testing and evaluation of the noise variance components

    Science.gov (United States)

    Behnabian, Behzad; Mashhadi Hossainali, Masoud; Malekzadeh, Ahad

    2018-02-01

    The cross-validation technique is a popular method to assess and improve the quality of prediction by least squares collocation (LSC). We present a formula for direct estimation of the vector of cross-validation errors (CVEs) in LSC which is much faster than element-wise CVE computation. We show that a quadratic form of CVEs follows Chi-squared distribution. Furthermore, a posteriori noise variance factor is derived by the quadratic form of CVEs. In order to detect blunders in the observations, estimated standardized CVE is proposed as the test statistic which can be applied when noise variances are known or unknown. We use LSC together with the methods proposed in this research for interpolation of crustal subsidence in the northern coast of the Gulf of Mexico. The results show that after detection and removing outliers, the root mean square (RMS) of CVEs and estimated noise standard deviation are reduced about 51 and 59%, respectively. In addition, RMS of LSC prediction error at data points and RMS of estimated noise of observations are decreased by 39 and 67%, respectively. However, RMS of LSC prediction error on a regular grid of interpolation points covering the area is only reduced about 4% which is a consequence of sparse distribution of data points for this case study. The influence of gross errors on LSC prediction results is also investigated by lower cutoff CVEs. It is indicated that after elimination of outliers, RMS of this type of errors is also reduced by 19.5% for a 5 km radius of vicinity. We propose a method using standardized CVEs for classification of dataset into three groups with presumed different noise variances. The noise variance components for each of the groups are estimated using restricted maximum-likelihood method via Fisher scoring technique. Finally, LSC assessment measures were computed for the estimated heterogeneous noise variance model and compared with those of the homogeneous model. The advantage of the proposed method is the

  14. Visual-based simultaneous localization and mapping and global positioning system correction for geo-localization of a mobile robot

    International Nuclear Information System (INIS)

    Berrabah, Sid Ahmed; Baudoin, Yvan; Sahli, Hichem

    2011-01-01

    This paper introduces an approach combining visual-based simultaneous localization and mapping (V-SLAM) and global positioning system (GPS) correction for accurate multi-sensor localization of an outdoor mobile robot in geo-referenced maps. The proposed framework combines two extended Kalman filters (EKF); the first one, referred to as the integration filter, is dedicated to the improvement of the GPS localization based on data from an inertial navigation system and wheels' encoders. The second EKF implements the V-SLAM process. The linear and angular velocities in the dynamic model of the V-SLAM EKF filter are given by the GPS/INS/Encoders integration filter. On the other hand, the output of the V-SLAM EKF filter is used to update the dynamics estimation in the integration filter and therefore the geo-referenced localization. This solution increases the accuracy and the robustness of the positioning during GPS outage and allows SLAM in less featured environments

  15. Fiber based optical tweezers for simultaneous in situ force exertion and measurements in a 3D polyacrylamide gel compartment.

    Science.gov (United States)

    Ti, Chaoyang; Thomas, Gawain M; Ren, Yundong; Zhang, Rui; Wen, Qi; Liu, Yuxiang

    2015-07-01

    Optical tweezers play an important role in biological applications. However, it is difficult for traditional optical tweezers based on objective lenses to work in a three-dimensional (3D) solid far away from the substrate. In this work, we develop a fiber based optical trapping system, namely inclined dual fiber optical tweezers, that can simultaneously apply and measure forces both in water and in a 3D polyacrylamide gel matrix. In addition, we demonstrate in situ, non-invasive characterization of local mechanical properties of polyacrylamide gel by measurements on an embedded bead. The fiber optical tweezers measurements agree well with those of atomic force microscopy (AFM). The inclined dual fiber optical tweezers provide a promising and versatile tool for cell mechanics study in 3D environments.

  16. Efficient global optimization based 3D carotid AB-LIB MRI segmentation by simultaneously evolving coupled surfaces.

    Science.gov (United States)

    Ukwatta, Eranga; Yuan, Jing; Rajchl, Martin; Fenster, Aaron

    2012-01-01

    Magnetic resonance (MR) imaging of carotid atherosclerosis biomarkers are increasingly being investigated for the risk assessment of vulnerable plaques. A fast and robust 3D segmentation of the carotid adventitia (AB) and lumen-intima (LIB) boundaries can greatly alleviate the measurement burden of generating quantitative imaging biomarkers in clinical research. In this paper, we propose a novel global optimization-based approach to segment the carotid AB and LIB from 3D T1-weighted black blood MR images, by simultaneously evolving two coupled surfaces with enforcement of anatomical consistency of the AB and LIB. We show that the evolution of two surfaces at each discrete time-frame can be optimized exactly and globally by means of convex relaxation. Our continuous max-flow based algorithm is implemented in GPUs to achieve high computational performance. The experiment results from 16 carotid MR images show that the algorithm obtained high agreement with manual segmentations and achieved high repeatability in segmentation.

  17. Simultaneous Synthesis and Biotinylation of Proteins Using Puromycin-Based Labeling Technology for Fabrication of Protein Array Chip

    Science.gov (United States)

    Kumal, Subhashini Raj; Biyani, Manish; Ueno, Shingo; Akagi, Takanori; Ichiki, Takanori

    2013-06-01

    Protein arrays represent a class of devices that are of growing importance in the field of proteomics. These arrays enable screening of a large amount of proteins in a short time and at a lower cost. Here we present a method to fabricate protein array using biotin-conjugated puromycin to simultaneously synthesize and label proteins followed by immobilization onto streptavidin-functionalized surface based on the noncovalent biotin-streptavidin interaction. This method demonstrates the fabrication of protein array based on cell-free transcription/translation system using unmodified DNA as a starting genetic material. As a consequence, the procedure of protein arraying has been greatly simplified over the conventional approaches that require tedious and multi-step reactions. Further, an integrated approach of micro reactor array technology makes this method very simple and robust for achieving high-density protein arrays.

  18. Interval ANOVA simultaneous component analysis (i-ASCA) applied to spectroscopic data to study the effect of fundamental fermentation variables in beer fermentation metabolites

    DEFF Research Database (Denmark)

    Grassi, Silvia; Lyndgaard, Christian Bøge; Rasmussen, Morten Arendt

    2017-01-01

    This study explores the effect of different settings on beer fermentation process applying an interval-based version of ASCA on FT-IR data. Three main factors (yeast type, temperature, fermentation time) are included in the experimental design, being high sources of variation in brewing and stric...... and temperature, in smaller variable regions. The proposed approach demonstrates how interval-ASCA on FT-IR data, isolating the variation in the data according to the experimental design used, allows a rapid and accurate test for parameter control in beer manufacturing....

  19. A novel paper-based assay for the simultaneous determination of Rh typing and forward and reverse ABO blood groups.

    Science.gov (United States)

    Noiphung, Julaluk; Talalak, Kwanrutai; Hongwarittorrn, Irin; Pupinyo, Naricha; Thirabowonkitphithan, Pannawich; Laiwattanapaisal, Wanida

    2015-05-15

    We propose a new, paper-based analytical device (PAD) for blood typing that allows for the simultaneous determination of ABO and Rh blood groups on the same device. The device was successfully fabricated by using a combination of wax printing and wax dipping methods. A 1:2 blood dilution was used for forward grouping, whereas whole blood could be used for reverse grouping. A 30% cell suspension of A-cells or B-cells was used for haemagglutination on the reverse grouping side. The total assay time was 10 min. The ratio between the distance of red blood cell movement and plasma separation is the criterion for agglutination and indicates the presence of the corresponding antigen or antibody. The proposed PAD has excellent reproducibility in that the same blood groups, namely A, AB, and O, were reported by using different PADs that were fabricated on the same day (n=10). The accuracy for detecting blood group A (n=12), B (n=13), AB (n=9), O (n=14), and Rh (n=48) typing were 92%, 85%, 89%, 93%, and 96%, respectively, in comparison with the conventional slide test method. The haematocrit of the sample affects the accuracy of the results, and appropriate dilution is suggested before typing. In conclusion, this study proposes a novel method that is straightforward, time-saving, and inexpensive for the simultaneous determination of ABO and Rh blood groups, which is promising for use in developing countries. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Reverse Transcription Polymerase Chain Reaction-based System for Simultaneous Detection of Multiple Lily-infecting Viruses

    Directory of Open Access Journals (Sweden)

    Ji Yeon Kwon

    2013-09-01

    Full Text Available A detection system based on a multiplex reverse transcription (RT polymerase chain reaction (PCR was developed to simultaneously identify multiple viruses in the lily plant. The most common viruses infecting lily plants are the cucumber mosaic virus (CMV, lily mottle virus (LMoV, lily symptomless virus (LSV. Leaf samples were collected at lily-cultivation facilities located in the Kangwon province of Korea and used to evaluate the detection system. Simplex and multiplex RT-PCR were performed using virus-specific primers to detect single-or mixed viral infections in lily plants. Our results demonstrate the selective detection of 3 different viruses (CMV, LMoV and LSV by using specific primers as well as the potential of simultaneously detecting 2 or 3 different viruses in lily plants with mixed infections. Three sets of primers for each target virus, and one set of internal control primers were used to evaluate the detection system for efficiency, reliability, and reproducibility.

  1. A SIMULTANEOUS MULTI-PROBE DETECTION LABEL-FREE OPTICAL-RESOLUTION PHOTOACOUSTIC MICROSCOPY TECHNIQUE BASED ON MICROCAVITY TRANSDUCER

    Directory of Open Access Journals (Sweden)

    YONGBO WU

    2013-07-01

    Full Text Available We demonstrate the feasibility of simultaneous multi-probe detection for an optical-resolution photoacoustic microscopy (OR-PAM system. OR-PAM has elicited the attention of biomedical imaging researchers because of its optical absorption contrast and high spatial resolution with great imaging depth. OR-PAM allows label-free and noninvasive imaging by maximizing the optical absorption of endogenous biomolecules. However, given the inadequate absorption of some biomolecules, detection sensitivity at the same incident intensity requires improvement. In this study, a modulated continuous wave with power density less than 3 mW/cm2 (1/4 of the ANSI safety limit excited the weak photoacoustic (PA signals of biological cells. A microcavity transducer is developed based on the bulk modulus of gas five orders of magnitude lower than that of solid; air pressure variation is inversely proportional to cavity volume at the same temperature increase. Considering that a PA wave expands in various directions, detecting PA signals from different positions and adding them together can increase detection sensitivity and signal-to-noise ratio. Therefore, we employ four detectors to acquire tiny PA signals simultaneously. Experimental results show that the developed OR-PAM system allows the label-free imaging of cells with weak optical absorption.

  2. Fitting model-based psychometric functions to simultaneity and temporal-order judgment data: MATLAB and R routines.

    Science.gov (United States)

    Alcalá-Quintana, Rocío; García-Pérez, Miguel A

    2013-12-01

    Research on temporal-order perception uses temporal-order judgment (TOJ) tasks or synchrony judgment (SJ) tasks in their binary SJ2 or ternary SJ3 variants. In all cases, two stimuli are presented with some temporal delay, and observers judge the order of presentation. Arbitrary psychometric functions are typically fitted to obtain performance measures such as sensitivity or the point of subjective simultaneity, but the parameters of these functions are uninterpretable. We describe routines in MATLAB and R that fit model-based functions whose parameters are interpretable in terms of the processes underlying temporal-order and simultaneity judgments and responses. These functions arise from an independent-channels model assuming arrival latencies with exponential distributions and a trichotomous decision space. Different routines fit data separately for SJ2, SJ3, and TOJ tasks, jointly for any two tasks, or also jointly for the three tasks (for common cases in which two or even the three tasks were used with the same stimuli and participants). Additional routines provide bootstrap p-values and confidence intervals for estimated parameters. A further routine is included that obtains performance measures from the fitted functions. An R package for Windows and source code of the MATLAB and R routines are available as Supplementary Files.

  3. A simple simultaneous flow injection method based on phosphomolybdenum chemistry for nitrate and nitrite determinations in water and fish samples.

    Science.gov (United States)

    Monser, L; Sadok, S; Greenway, G M; Shah, I; Uglow, R F

    2002-05-24

    A direct spectrophotometric flow injection method for the simultaneous determination of nitrite and nitrate has been developed. The method is based on the oxidation of a phosphomolybdenum blue complex by the addition of nitrite and the decrease in absorbance of the blue complex is monitored at 820 nm. The injected sample is split into two segments. One of the streams was directly reacted with the above reagent and detected as nitrite. The other stream was passed through a copperised cadmium reductor column where reduction of nitrate to nitrite occurs, and the sample was then mixed with the reagent and passed through the cell of the spectrophotometer to be detected as nitrite plus nitrate. The conditions for the flow injection manifold parameters were optimised by experimental design and the concentration of nitrite and nitrate was determined in the linear range from 0.05 to 1.15 mug ml(-1) nitrite and 0.06 to 1.6 mug ml(-1) nitrate with a detection limit of 0.01 mug ml(-1) for nitrite and 0.025 mug ml(-1) for nitrate. The method is suitable for the simultaneous determination of nitrite and nitrate in fish and water samples with a sampling rate of 25+/-2 sample per hour.

  4. A Simultaneous Biogeography based Optimal Placement of DG Units and Capacitor Banks in Distribution Systems with Nonlinear Loads

    Science.gov (United States)

    Sadeghi, Hassan; Ghaffarzadeh, Navid

    2016-09-01

    This paper uses a new algorithm namely biogeography based optimization (BBO) intended for the simultaneous placement of the distributed generation (DG) units and the capacitor banks in the distribution network. The procedure of optimization has been conducted in the presence of nonlinear loads (a cause of harmonic injection). The purpose of simultaneous optimal placement of the DG and the capacitor is the reduction of active and reactive losses. The difference in the values of loss reduction at different levels of the load have been included in the objective function and the considered objective function includes the constraints of voltage, size and the number of DG units and capacitor banks and the allowable range of the total harmonic distortion (THD) of the total voltage in accordance with the IEEE 519 standards. In this paper the placement has been performed on two load types ie constant and mixed power, moreover the effects of load models on the results and the effects of optimal placement on reduction of the THD levels have also been analyzed. The mentioned cases have been studied on a 33 bus radial distribution system.

  5. Quantitative evaluation of Radix Paeoniae Alba sulfur-fumigated with different durations and purchased from herbal markets: simultaneous determination of twelve components belonging to three chemical types by improved high performance liquid chromatography-diode array detector.

    Science.gov (United States)

    Kong, Ming; Liu, Huan-Huan; Xu, Jun; Wang, Chun-Ru; Lu, Ming; Wang, Xiao-Ning; Li, You-Bin; Li, Song-Lin

    2014-09-01

    In this study, a improved high performance liquid chromatography-diode array detector (HPLC-DAD) method for simultaneous quantification of twelve major components belonging to three chemical types was developed and validated, and was applied to quantitatively compare the quality of Radix Paeoniae Alba (RPA) sulfur-fumigated with different durations and purchased from commercial herbal markets. The contents of paeoniflorin, benzoylpaeoniflorin, oxypaeoniflorin, benzoic acid and paeonol decreased whereas that of paeoniflorin sulfonate increased in RPA with the extending of sulfur-fumigation duration. Different levels of paeoniflorin sulfonate were determined in ten of seventeen commercial RPA samples, indicating that these ten samples may be sulfur-fumigated with different durations. Moreover, the relative standard deviation of the contents of each component was higher in the commercial sulfur-fumigated RPA samples than that in commercial non-fumigated RPA samples, and the percentage of the total average content of monoterpene glycosides in the determined analytes was higher in the decoctions of commercial sulfur-fumigated RPA than that in commercial non-fumigated RPA samples. All these results suggested that the established method was precise, accurate and sensitive enough for the global quality evaluation of sulfur-fumigated RPA, and sulfur-fumigation can not only change the proportions of bioactive components, but also cause the reduction of the quality consistency of both raw materials and aqueous decoctions of RPA. Copyright © 2014 Elsevier B.V. All rights reserved.

  6. Simultaneous solvent and J-modulation suppression in PGSTE-based diffusion experiments

    Science.gov (United States)

    Sinnaeve, Davy

    2014-08-01

    The most favourable solvent suppression methods that have been applied to PGSTE experiments for the measurement of diffusion are WATERGATE and excitation sculpting. However, both methods come with significant J-modulation line-shape distortions on multiplets, a phenomenon that is known to be of particular concern for DOSY data processing. Here, two new PGSTE experiments are proposed that suppress both the solvent peak and J-modulation based on the perfect echo WATERGATE sequence. This allows narrow suppression bandwidths and thus measurement of diffusion on peaks close to the solvent peak. Both sequences perform admirably and the better option depends on the priority one puts on the quality of the solvent suppression or signal loss due to T2 weighting. Gradient-based solvent suppression in PGSTE experiments can often be compromised by the variable, diffusion-encoding gradient pulses. Special emphasis is put on how to maximise the robustness of the solvent suppression.

  7. An innovative browser-based data exploration tool with simultaneous scrolling in time and wavelength domains

    Science.gov (United States)

    Slater, Gregory L.; Schiff, David; De Pontieu, Bart; Tarbell, Theodore D.; Freeland, Samuel L.

    2017-08-01

    We present Cruiser, a new web tool for the precision interactive blending of image series across time and wavelength domains. Scrolling in two dimensions enables discovery and investigation of similarities and differences in structure and evolution across multiple wavelengths. Cruiser works in the latest versions of standards compliant browsers on both desktop and IOS platforms. Co-aligned data cubes have been generated for AIA, IRIS, and Hinode SOT FG, and image data from additional instruments, both space-based and ground-based, can be data sources. The tool has several movie playing and image adjustment controls which will be described in the poster and demonstrated on a MacOS notebook and iPad.

  8. Identifiability study of the proteins degradation model, based on ADM1, using simultaneous batch experiments

    DEFF Research Database (Denmark)

    Flotats, X.; Palatsi, J.; Ahring, Birgitte Kiær

    2006-01-01

    The objective of the present study is to analyse kinetic and stoichiometric parameter values of gelatine anaerobic degradation at thermophilic range, based on an experiment designed to elucidate if volatile fatty acids (VFA) are inhibitors of the hydrolysis process. Results showed that VFA...... are not inhibiting the hydrolysis process. The ADM1 model adequately expressed the consecutive steps of hydrolysis and acidogenesis, with estimated kinetic values corresponding to a fast acidogenesis and slower hydrolysis. The hydrolysis was found to be the rate limiting step of anaerobic degradation. Estimation...... of yield coefficients based on the relative initial slopes of VFA profiles obtained in a simple batch experiment produced satisfactory results. From the identification study, it was concluded that it is possible to determine univocally the related kinetic parameter values for protein degradation...

  9. Simultaneous and synergistic profiling of cloud and drizzle properties using ground-based observations

    Science.gov (United States)

    Rusli, Stephanie P.; Donovan, David P.; Russchenberg, Herman W. J.

    2017-12-01

    Despite the importance of radar reflectivity (Z) measurements in the retrieval of liquid water cloud properties, it remains nontrivial to interpret Z due to the possible presence of drizzle droplets within the clouds. So far, there has been no published work that utilizes Z to identify the presence of drizzle above the cloud base in an optimized and a physically consistent manner. In this work, we develop a retrieval technique that exploits the synergy of different remote sensing systems to carry out this task and to subsequently profile the microphysical properties of the cloud and drizzle in a unified framework. This is accomplished by using ground-based measurements of Z, lidar attenuated backscatter below as well as above the cloud base, and microwave brightness temperatures. Fast physical forward models coupled to cloud and drizzle structure parameterization are used in an optimal-estimation-type framework in order to retrieve the best estimate for the cloud and drizzle property profiles. The cloud retrieval is first evaluated using synthetic signals generated from large-eddy simulation (LES) output to verify the forward models used in the retrieval procedure and the vertical parameterization of the liquid water content (LWC). From this exercise it is found that, on average, the cloud properties can be retrieved within 5 % of the mean truth. The full cloud-drizzle retrieval method is then applied to a selected ACCEPT (Analysis of the Composition of Clouds with Extended Polarization Techniques) campaign dataset collected in Cabauw, the Netherlands. An assessment of the retrieval products is performed using three independent methods from the literature; each was specifically developed to retrieve only the cloud properties, the drizzle properties below the cloud base, or the drizzle fraction within the cloud. One-to-one comparisons, taking into account the uncertainties or limitations of each retrieval, show that our results are consistent with what is derived

  10. Common components of evidence-based parenting programs for preventing maltreatment of school-age children.

    Science.gov (United States)

    Temcheff, Caroline E; Letarte, Marie-Josée; Boutin, Stéphanie; Marcil, Katherine

    2018-04-06

    Child maltreatment can lead to a variety of negative outcomes in childhood including physical and mental health problems that can extend into adulthood. Given the transactional nature of child maltreatment and the difficulties that many maltreating families experience, child protection services typically offer various kinds of programs to maltreated children, their parents, and/or their families. Although the specific difficulties experienced by these families may vary, sub-optimal parenting practices are typically part of the picture and may play a central role in maltreated children's development. Hence, to deal with child maltreatment, programs that focus on parenting practices are essential, and identifying the common components of effective programs is of critical importance. The objectives of the present study were to: 1) describe the components of evidence-based parenting programs aimed at parents who have maltreated their elementary school-aged children or are at-risk for doing so and 2) identify the components that are common to these programs, using the approach proposed by Barth and Liggett-Creel (2014). Fourteen evidence-based parenting programs aimed at parents who had maltreated their elementary school-aged children (ages 6-12) or were at-risk for doing so were identified using both a review of relevant online databases of evidence-based programs (California Evidence-Based Clearinghouse for Child Welfare, Blueprints for Healthy Youth Development, Youth.gov, and the National Registry of Evidence-based Programs and Practices). Common components were identified (operationalized as components present in two thirds of programs) and discussed. The identification of common components of evidence-based programs may help clinicians choose the best intervention methods. Copyright © 2018. Published by Elsevier Ltd.

  11. Simultaneous detection and removal of radioisotopes with modified alginate beads containing an azo-based probe using RGB coordinates

    International Nuclear Information System (INIS)

    Jo, Ara; Jang, Geunseok; Namgung, Ho; Kim, Choongho; Kim, Daigeun; Kim, Yujun; Kim, Jongho; Lee, Taek Seung

    2015-01-01

    Highlights: • Modified alginate with azo-based probe (ABO) was synthesized by a reaction between sodium alginate and azo-based probe (BO2). • BO2 was found to be a good probe molecule for radioisotopes using colorimetric analysis. • Detection of Co 2+ and Sr 2+ was mainly carried out via interaction between BO2 and metal ions. • Simultaneous removal of radioisotopes was assessed by the ion-exchange of carboxylate groups in sodium alginate. • The alginate beads with dual functions of detection and removal of metal ions are successfully accomplished. - Abstract: We prepared alginate beads that were modified with an azo-based probe molecule to monitor simultaneously the removal (by alginate) and probing (by the azo-probe molecule) of radioisotopes such as cobalt, strontium, and cesium ions. As an azo-probe molecule, Basic Orange 2 (BO2) was immobilized to the alginate bead. The BO2 in aqueous solution exhibited a slight red shift in absorption with a change in color from orange to dark orange upon addition of cobalt and strontium ions. In contrast, the color of BO2 did not change upon exposure to cesium ions. Thus, the covalently embedded BO2 in alginate beads could adsorb cobalt and strontium ions resulting in recognizable color change of the beads, which was induced by the formation of a complex between BO2 and metal ions. The color changes of the beads in the presence of metal ions were determined quantitatively using RGB color coordinate values. In addition to effectively removing metal ions, the colorimetric coordinate method provides a convenient and simple sensing technique for naked-eye metal ion detection.

  12. Predictive based monitoring of nuclear plant component degradation using support vector regression

    Energy Technology Data Exchange (ETDEWEB)

    Agarwal, Vivek [Idaho National Lab. (INL), Idaho Falls, ID (United States). Dept. of Human Factors, Controls, Statistics; Alamaniotis, Miltiadis [Purdue Univ., West Lafayette, IN (United States). School of Nuclear Engineering; Tsoukalas, Lefteri H. [Purdue Univ., West Lafayette, IN (United States). School of Nuclear Engineering

    2015-02-01

    Nuclear power plants (NPPs) are large installations comprised of many active and passive assets. Degradation monitoring of all these assets is expensive (labor cost) and highly demanding task. In this paper a framework based on Support Vector Regression (SVR) for online surveillance of critical parameter degradation of NPP components is proposed. In this case, on time replacement or maintenance of components will prevent potential plant malfunctions, and reduce the overall operational cost. In the current work, we apply SVR equipped with a Gaussian kernel function to monitor components. Monitoring includes the one-step-ahead prediction of the component’s respective operational quantity using the SVR model, while the SVR model is trained using a set of previous recorded degradation histories of similar components. Predictive capability of the model is evaluated upon arrival of a sensor measurement, which is compared to the component failure threshold. A maintenance decision is based on a fuzzy inference system that utilizes three parameters: (i) prediction evaluation in the previous steps, (ii) predicted value of the current step, (iii) and difference of current predicted value with components failure thresholds. The proposed framework will be tested on turbine blade degradation data.

  13. A component-based open hypermedia approach to integreting structure services

    DEFF Research Database (Denmark)

    Grønbæk, Kaj; Nürnberg, Peter J.; Bucka-Lassen, Dirk

    1999-01-01

    In this paper, we consider the issue of integrating different structure services within a component-based open hypermedia system. We do so by considering the task of collaborative editing, which calls for a variety of different structures traditionally supplied by different structure services. We...... discuss the nature of collaborative editing and how it can be supported by a combination of spatial and navigational hypermedia services. We then present a component-based open hypermedia system architecture and describe various methods of integrating different structure services provided within...

  14. Component-Based Development of Runtime Observers in the COMDES Framework

    DEFF Research Database (Denmark)

    Guan, Wei; Li, Gang; Angelov, Christo K.

    2013-01-01

    Formal verification methods, such as exhaustive model checking, are often infeasible because of high computational complexity. Runtime observers (monitors) provide an alternative, light-weight verification method, which offers a non-exhaustive but still feasible approach to monitor system behavior...... against formally specified properties. This paper presents a component-based design method for runtime observers in the context of COMDES framework—a component-based framework for distributed embedded system and its supporting tools. Therefore, runtime verification is facilitated by model...

  15. Prognostic Health Monitoring System: Component Selection Based on Risk Criteria and Economic Benefit Assessment

    International Nuclear Information System (INIS)

    Pham, Binh T.; Agarwal, Vivek; Lybeck, Nancy J.; Tawfik, Magdy S.

    2012-01-01

    Prognostic health monitoring (PHM) is a proactive approach to monitor the ability of structures, systems, and components (SSCs) to withstand structural, thermal, and chemical loadings over the SSCs planned service lifespan. The current efforts to extend the operational license lifetime of the aging fleet of U.S. nuclear power plants from 40 to 60 years and beyond can benefit from a systematic application of PHM technology. Implementing a PHM system would strengthen the safety of nuclear power plants, reduce plant outage time, and reduce operation and maintenance costs. However, a nuclear power plant has thousands of SSCs, so implementing a PHM system that covers all SSCs requires careful planning and prioritization. This paper therefore focuses on a component selection that is based on the analysis of a component's failure probability, risk, and cost. Ultimately, the decision on component selection depends on the overall economical benefits arising from safety and operational considerations associated with implementing the PHM system. (author)

  16. Simultaneous quantification of eight bioactive components of Houttuynia cordata and related Saururaceae medicinal plants by on-line high performance liquid chromatography-diode array detector-electrospray mass spectrometry.

    Science.gov (United States)

    Meng, Jiang; Leung, Kelvin Sze-Yin; Dong, Xiao-Ping; Zhou, Yi-Sheng; Jiang, Zhi-Hong; Zhao, Zhong-Zhen

    2009-12-01

    An on-line high performance liquid chromatography (HPLC)-diode array detector (DAD)-electrospray ionization mass spectrometry (ESI-MS) method has been developed to quantify simultaneously eight bioactive chemical components in Houttuynia cordata Thunb and related Saururaceae medicinal plants. Simultaneous separation of these eight compounds was achieved on a C(18) analytical column with gradient elution of acetonitrile and 0.2% acetic acid (v/v) at a flow rate of 0.6 mL/min and being detected at 280 nm. These eight compounds were completely separated within 90 min. Good linear regression relationship (r(2)>0.9978) within test ranges was shown in all calibration curves. Good repeatabilty for the quantification of these eight compounds in H.cordata was also demonstrated in this method, with intra- and inter-day variations less than 3.0%. The method established was successfully applied to quantify eight bioactive compounds in closely related species of H.cordata, which provides a new basis for quality assessment of H.cordata.

  17. System Description and First Application of an FPGA-Based Simultaneous Multi-Frequency Electrical Impedance Tomography

    Directory of Open Access Journals (Sweden)

    Susana Aguiar Santos

    2016-07-01

    Full Text Available A new prototype of a multi-frequency electrical impedance tomography system is presented. The system uses a field-programmable gate array as a main controller and is configured to measure at different frequencies simultaneously through a composite waveform. Both real and imaginary components of the data are computed for each frequency and sent to the personal computer over an ethernet connection, where both time-difference imaging and frequency-difference imaging are reconstructed and visualized. The system has been tested for both time-difference and frequency-difference imaging for diverse sets of frequency pairs in a resistive/capacitive test unit and in self-experiments. To our knowledge, this is the first work that shows preliminary frequency-difference images of in-vivo experiments. Results of time-difference imaging were compared with simulation results and shown that the new prototype performs well at all frequencies in the tested range of 60 kHz–960 kHz. For frequency-difference images, further development of algorithms and an improved normalization process is required to correctly reconstruct and interpreted the resulting images.

  18. In vitro wear of resin-based materials--simultaneous corrosive and abrasive wear.

    Science.gov (United States)

    Correr, Gisele Maria; Bruschi Alonso, Roberta Caroline; Correr Sobrinho, Lourenço; Puppin-Rontani, Regina Maria; Ferracane, Jack Liborio

    2006-07-01

    The aim of this study was to evaluate the wear of resin-based materials caused by the association of abrasive and corrosive processes. Twenty specimens were prepared for each material, cast in epoxy in acrylic rings, polished, and profiled with an MTS 3D Profiler. Antagonists were made from deciduous molars. Specimens were distributed into eight groups (n = 10), according to the material (Filtek Supreme, Point 4, Dyract AP, and Fuji II LC) and the type of slurry (neutral and acidic), and then cycled 100,000 times in the OHSU oral wear simulator. The specimens were cleaned and reprofiled. Volume loss and maximum depth were determined. ANOVA and Tukey's test were used for data analysis (p wear facet on the antagonist was also measured. Composites displayed less wear than the compomer and the resin-modified glass ionomer. Significant differences also were found for cusp wear, with a significant positive correlation shown between cusp and material wear. The acidic slurry significantly increased the wear of the materials compared to the neutral slurry. Exposure to acidic slurry accelerated the wear of resin-based materials.

  19. Enhancing the Dialogue in Simultaneous Class-Based and Live Video-Streamed Teaching

    DEFF Research Database (Denmark)

    Jelsbak, Vibe Alopaeus; Bendsen, Thomas; Thorsen, Jonas

    Abstract: The bachelor programme in biomedical laboratory analysis at VIA University College in Aarhus has established a blended class concept which combines traditional and live broadcast teaching. 1-2 days a week students have the choice either to attend teaching sessions in the traditional way...... or to work from home via the Internet. In live video-streamed teaching classes teachers tend to choose one-way communication instead of dialogue. We know from our early findings that technology issues are one of the main reasons for this, since the same teachers use dialogue and discussions in traditional...... teaching. This paper describes a work-in-progress project focused on developing possibilities for a more dialogue-based approach to live video-streamed teaching. We present our new setup and argue for educational de- signs which this is believed to support, and we outline the research design for collecting...

  20. Enhancing the Dialogue in Simultaneous Class-Based and Live Video-Streamed Teaching

    DEFF Research Database (Denmark)

    Jelsbak, Vibe Alopaeus; Ørngreen, Rikke; Thorsen, Jonas

    2015-01-01

    The bachelor programme in biomedical laboratory analysis at VIA University College in Aarhus has established a blended class concept which combines traditional and live broadcast teaching. 1-2 days a week students have the choice either to attend teaching sessions in the traditional way or to work...... from home via the Internet. In live video-streamed teaching classes teachers tend to choose one-way communication instead of dialogue. We know from our early findings that technology issues are one of the main reasons for this, since the same teachers use dialogue and discussions in traditional...... teaching. This paper describes a work-in-progress project focused on developing possibilities for a more dialogue-based approach to live video-streamed teaching. We present our new setup and argue for educational designs which this is believed to support, and we outline the research design for collecting...

  1. Ionic-Liquid-Based Acidic Aqueous Biphasic Systems for Simultaneous Leaching and Extraction of Metallic Ions.

    Science.gov (United States)

    Gras, Matthieu; Papaiconomou, Nicolas; Schaeffer, Nicolas; Chainet, Eric; Tedjar, Farouk; Coutinho, Joao A P; Billard, Isabelle

    2018-02-05

    The first instance of an acidic aqueous biphasic system (AcABS) based on tributyltetradecyl phosphonium chloride ([P 44414 ][Cl]) and an acid is here reported. This AcABS exhibits pronounced thermomorphic behavior and is shown to be applicable to the extraction of metal ions from concentrated acidic solutions. Metal ions such as cobalt(II), iron(III), platinum(IV) and nickel(II) are found to partition preferentially to one of the phases of the acidic aqueous biphasic system and it is here shown that it successfully allows the difficult separation of Co II from Ni II , here studied at 24 and 50 °C. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Diode laser-based gas analyser for the simultaneous measurement of CO2 and HF in volcanic plumes

    Science.gov (United States)

    Chiarugi, Antonio; Viciani, Silvia; D'Amato, Francesco; Burton, Mike

    2018-01-01

    A portable analyser is described for simultaneous detection of CO2 and HF emitted by volcanoes and fumaroles. The system is based on two fibre-coupled distributed feedback lasers and only one multipass cell, and provides the absolute concentration values of the two gases, without requiring a calibration procedure, at a maximum rate of 4 Hz. The spectrometer can operate both in a closed-cell configuration and in an open-cell set-up, with the latter mitigating problems associated with chemisorption of the HF molecule. The concept, practical realization and laboratory performance of the device are presented, together with results from a first test campaign measuring volcanic gases emitted from the crater of Vulcano, Italy. We obtained an in-field sensitivity of 320 ppb for CO2 and 20 ppb for HF at 2 s integration time.

  3. Simultaneous lipolysis/permeation in vitro model, for the estimation of bioavailability of lipid based drug delivery systems

    DEFF Research Database (Denmark)

    Bibi, Hanady Ajine; Holm, René; Bauer-Brandl, Annette

    2017-01-01

    The simultaneous processes of lipid digestion and absorption together determine the oral bioavailability of drugs incorporated into lipid based drug delivery systems (LBDDS). A number of slightly different protocols for in vitro lipolysis are widely accepted; however, the permeation process has so......® during lipid digestion. Using calcein as a marker molecule the investigations demonstrated that the barrier was able to maintain its permeation properties in the presence of the SNEDDS (self-emulsifying drug delivery system) formulation, the lipolysis medium, and the lipolysis medium while digesting...... far not been included into the models due to the harsh conditions of lipid digestion compromising permeation barriers. The present study for the first time combines biomimetic permeation and lipolysis of LBDDS. The focus of the current work was on the functional stability of the barrier - Permeapad...

  4. Diode laser-based gas analyser for the simultaneous measurement of CO2 and HF in volcanic plumes

    Directory of Open Access Journals (Sweden)

    A. Chiarugi

    2018-01-01

    Full Text Available A portable analyser is described for simultaneous detection of CO2 and HF emitted by volcanoes and fumaroles. The system is based on two fibre-coupled distributed feedback lasers and only one multipass cell, and provides the absolute concentration values of the two gases, without requiring a calibration procedure, at a maximum rate of 4 Hz. The spectrometer can operate both in a closed-cell configuration and in an open-cell set-up, with the latter mitigating problems associated with chemisorption of the HF molecule. The concept, practical realization and laboratory performance of the device are presented, together with results from a first test campaign measuring volcanic gases emitted from the crater of Vulcano, Italy. We obtained an in-field sensitivity of 320 ppb for CO2 and 20 ppb for HF at 2 s integration time.

  5. Ca analysis: An Excel based program for the analysis of intracellular calcium transients including multiple, simultaneous regression analysis☆

    Science.gov (United States)

    Greensmith, David J.

    2014-01-01

    Here I present an Excel based program for the analysis of intracellular Ca transients recorded using fluorescent indicators. The program can perform all the necessary steps which convert recorded raw voltage changes into meaningful physiological information. The program performs two fundamental processes. (1) It can prepare the raw signal by several methods. (2) It can then be used to analyze the prepared data to provide information such as absolute intracellular Ca levels. Also, the rates of change of Ca can be measured using multiple, simultaneous regression analysis. I demonstrate that this program performs equally well as commercially available software, but has numerous advantages, namely creating a simplified, self-contained analysis workflow. PMID:24125908

  6. Ca analysis: an Excel based program for the analysis of intracellular calcium transients including multiple, simultaneous regression analysis.

    Science.gov (United States)

    Greensmith, David J

    2014-01-01

    Here I present an Excel based program for the analysis of intracellular Ca transients recorded using fluorescent indicators. The program can perform all the necessary steps which convert recorded raw voltage changes into meaningful physiological information. The program performs two fundamental processes. (1) It can prepare the raw signal by several methods. (2) It can then be used to analyze the prepared data to provide information such as absolute intracellular Ca levels. Also, the rates of change of Ca can be measured using multiple, simultaneous regression analysis. I demonstrate that this program performs equally well as commercially available software, but has numerous advantages, namely creating a simplified, self-contained analysis workflow. Copyright © 2013 The Author. Published by Elsevier Ireland Ltd.. All rights reserved.

  7. Limited angle CT reconstruction by simultaneous spatial and Radon domain regularization based on TV and data-driven tight frame

    Science.gov (United States)

    Zhang, Wenkun; Zhang, Hanming; Wang, Linyuan; Cai, Ailong; Li, Lei; Yan, Bin

    2018-02-01

    Limited angle computed tomography (CT) reconstruction is widely performed in medical diagnosis and industrial testing because of the size of objects, engine/armor inspection requirements, and limited scan flexibility. Limited angle reconstruction necessitates usage of optimization-based methods that utilize additional sparse priors. However, most of conventional methods solely exploit sparsity priors of spatial domains. When CT projection suffers from serious data deficiency or various noises, obtaining reconstruction images that meet the requirement of quality becomes difficult and challenging. To solve this problem, this paper developed an adaptive reconstruction method for limited angle CT problem. The proposed method simultaneously uses spatial and Radon domain regularization model based on total variation (TV) and data-driven tight frame. Data-driven tight frame being derived from wavelet transformation aims at exploiting sparsity priors of sinogram in Radon domain. Unlike existing works that utilize pre-constructed sparse transformation, the framelets of the data-driven regularization model can be adaptively learned from the latest projection data in the process of iterative reconstruction to provide optimal sparse approximations for given sinogram. At the same time, an effective alternating direction method is designed to solve the simultaneous spatial and Radon domain regularization model. The experiments for both simulation and real data demonstrate that the proposed algorithm shows better performance in artifacts depression and details preservation than the algorithms solely using regularization model of spatial domain. Quantitative evaluations for the results also indicate that the proposed algorithm applying learning strategy performs better than the dual domains algorithms without learning regularization model

  8. A likelihood-based biostatistical model for analyzing consumer movement in simultaneous choice experiments.

    Science.gov (United States)

    Zeilinger, Adam R; Olson, Dawn M; Andow, David A

    2014-08-01

    Consumer feeding preference among resource choices has critical implications for basic ecological and evolutionary processes, and can be highly relevant to applied problems such as ecological risk assessment and invasion biology. Within consumer choice experiments, also known as feeding preference or cafeteria experiments, measures of relative consumption and measures of consumer movement can provide distinct and complementary insights into the strength, causes, and consequences of preference. Despite the distinct value of inferring preference from measures of consumer movement, rigorous and biologically relevant analytical methods are lacking. We describe a simple, likelihood-based, biostatistical model for analyzing the transient dynamics of consumer movement in a paired-choice experiment. With experimental data consisting of repeated discrete measures of consumer location, the model can be used to estimate constant consumer attraction and leaving rates for two food choices, and differences in choice-specific attraction and leaving rates can be tested using model selection. The model enables calculation of transient and equilibrial probabilities of consumer-resource association, which could be incorporated into larger scale movement models. We explore the effect of experimental design on parameter estimation through stochastic simulation and describe methods to check that data meet model assumptions. Using a dataset of modest sample size, we illustrate the use of the model to draw inferences on consumer preference as well as underlying behavioral mechanisms. Finally, we include a user's guide and computer code scripts in R to facilitate use of the model by other researchers.

  9. Representation of Students in Solving Simultaneous Linear Equation Problems Based on Multiple Intelligence

    Science.gov (United States)

    Yanti, Y. R.; Amin, S. M.; Sulaiman, R.

    2018-01-01

    This study described representation of students who have musical, logical-mathematic and naturalist intelligence in solving a problem. Subjects were selected on the basis of multiple intelligence tests (TPM) consists of 108 statements, with 102 statements adopted from Chislet and Chapman and 6 statements equal to eksistensial intelligences. Data were analyzed based on problem-solving tests (TPM) and interviewing. See the validity of the data then problem-solving tests (TPM) and interviewing is given twice with an analyzed using the representation indikator and the problem solving step. The results showed that: the stage of presenting information known, stage of devising a plan, and stage of carrying out the plan those three subjects were using same form of representation. While he stage of presenting information asked and stage of looking back, subject of logical-mathematic was using different forms of representation with subjects of musical and naturalist intelligence. From this research is expected to provide input to the teacher in determining the learning strategy that will be used by considering the representation of students with the basis of multiple intelligences.

  10. Simultaneous detection and classification of breast masses in digital mammograms via a deep learning YOLO-based CAD system.

    Science.gov (United States)

    Al-Masni, Mohammed A; Al-Antari, Mugahed A; Park, Jeong-Min; Gi, Geon; Kim, Tae-Yeon; Rivera, Patricio; Valarezo, Edwin; Choi, Mun-Taek; Han, Seung-Moo; Kim, Tae-Seong

    2018-04-01

    Automatic detection and classification of the masses in mammograms are still a big challenge and play a crucial role to assist radiologists for accurate diagnosis. In this paper, we propose a novel Computer-Aided Diagnosis (CAD) system based on one of the regional deep learning techniques, a ROI-based Convolutional Neural Network (CNN) which is called You Only Look Once (YOLO). Although most previous studies only deal with classification of masses, our proposed YOLO-based CAD system can handle detection and classification simultaneously in one framework. The proposed CAD system contains four main stages: preprocessing of mammograms, feature extraction utilizing deep convolutional networks, mass detection with confidence, and finally mass classification using Fully Connected Neural Networks (FC-NNs). In this study, we utilized original 600 mammograms from Digital Database for Screening Mammography (DDSM) and their augmented mammograms of 2,400 with the information of the masses and their types in training and testing our CAD. The trained YOLO-based CAD system detects the masses and then classifies their types into benign or malignant. Our results with five-fold cross validation tests show that the proposed CAD system detects the mass location with an overall accuracy of 99.7%. The system also distinguishes between benign and malignant lesions with an overall accuracy of 97%. Our proposed system even works on some challenging breast cancer cases where the masses exist over the pectoral muscles or dense regions. Copyright © 2018 Elsevier B.V. All rights reserved.

  11. Quantitative characterization of the carbon/carbon composites components based on video of polarized light microscope.

    Science.gov (United States)

    Li, Yixian; Qi, Lehua; Song, Yongshan; Chao, Xujiang

    2017-06-01

    The components of carbon/carbon (C/C) composites have significant influence on the thermal and mechanical properties, so a quantitative characterization of component is necessary to study the microstructure of C/C composites, and further to improve the macroscopic properties of C/C composites. Considering the extinction crosses of the pyrocarbon matrix have significant moving features, the polarized light microscope (PLM) video is used to characterize C/C composites quantitatively because it contains sufficiently dynamic and structure information. Then the optical flow method is introduced to compute the optical flow field between the adjacent frames, and segment the components of C/C composites from PLM image by image processing. Meanwhile the matrix with different textures is re-segmented by the length difference of motion vectors, and then the component fraction of each component and extinction angle of pyrocarbon matrix are calculated directly. Finally, the C/C composites are successfully characterized from three aspects of carbon fiber, pyrocarbon, and pores by a series of image processing operators based on PLM video, and the errors of component fractions are less than 15%. © 2017 Wiley Periodicals, Inc.

  12. Efficient real time OD matrix estimation based on principal component analysis

    NARCIS (Netherlands)

    Djukic, T.; Flötteröd, G.; Van Lint, H.; Hoogendoorn, S.P.

    2012-01-01

    In this paper we explore the idea of dimensionality reduction and approximation of OD demand based on principal component analysis (PCA). First, we show how we can apply PCA to linearly transform the high dimensional OD matrices into the lower dimensional space without significant loss of accuracy.

  13. A model for determining condition-based maintenance policies for deteriorating multi-component systems

    NARCIS (Netherlands)

    Hontelez, J.A.M.; Wijnmalen, D.J.D.

    1993-01-01

    We discuss a method to determine strategies for preventive maintenance of systems consisting of gradually deteriorating components. A model has been developed to compute not only the range of conditions inducing a repair action, but also inspection moments based on the last known condition value so

  14. Prototypic implementations of the building block for component based open Hypermedia systems (BB/CB-OHSs)

    DEFF Research Database (Denmark)

    Mohamed, Omer I. Eldai

    2005-01-01

    In this paper we describe the prototypic implementations of the BuildingBlock (BB/CB-OHSs) that proposed to address some of the Component-based Open Hypermedia Systems (CB-OHSs) issues, including distribution and interoperability [4, 11, 12]. Four service implementations were described below. The...

  15. On-line detection of toxic components using a microbial fuel cell-based biosensor

    NARCIS (Netherlands)

    Stein, N.E.; Hamelers, H.V.M.; Straten, van G.; Keesman, K.J.

    2012-01-01

    Safe drinking water without toxic chemicals is crucial for people's health. A recently developed sensor for the detection of toxic components in water is the microbial fuel cell (MFC)-based biosensor. In this biosensor, substrate consumption rate and metabolic activity of bacteria are directly

  16. Development of geophysical and geochemical data processing software based on component GIS

    International Nuclear Information System (INIS)

    Ke Dan; Yu Xiang; Wu Qubo; Han Shaoyang; Li Xi

    2013-01-01

    Based on component GIS and mixed programming techniques, a software which combines the basic GIS functions, conventional and unconventional data process methods for the regional geophysical and geochemical data together, is designed and developed. The software has many advantages, such as friendly interface, easy to use and utility functions and provides a useful platform for regional geophysical and geochemical data processing. (authors)

  17. Effective Web Design and Core Communication Issues: The Missing Components in Web-Based Distance Education.

    Science.gov (United States)

    Burch, Randall O.

    2001-01-01

    Discussion of Web-based distance education focuses on communication issues. Highlights include Internet communications; components of a Web site, including site architecture, user interface, information delivery method, and mode of feedback; elements of Web design, including conceptual design, sensory design, and reactive design; and a Web…

  18. Applications of a streak-camera-based imager with simultaneous high space and time resolution

    Science.gov (United States)

    Klick, David I.; Knight, Frederick K.

    1993-01-01

    A high-speed imaging device has been built that is capable of recording several hundred images over a time span of 25 to 400 ns. The imager is based on a streak camera, which provides both spatial and temporal resolution. The system's current angular resolution is 16 X 16 pixels, with a time resolution of 250 ps. It was initially employed to provide 3-D images of objects, in conjunction with a short-pulse (approximately 100 ps) laser. For the 3-D (angle-angle-range) laser radar, the 250 ps time resolution corresponds to a range resolution of 4 cm. In the 3-D system, light from a short-pulse laser (a frequency-doubled, Q-switched, mode-locked Nd:YAG laser operating at a wavelength of 532 nm) flood-illuminates a target of linear dimension approximately 1 m. The returning light from the target is imaged, and the image is dissected by a 16 X 16 array of optical fibers. At the other end of the fiber optic image converter, the 256 fibers form a vertical line array, which is input to the slit of a streak camera. The streak camera sweeps the input line across the output phosphor screen so that horizontal position is directly proportional to time. The resulting 2-D image (fiber location vs. time) at the phosphor is read by an intensified (SIT) vidicon TV tube, and the image is digitized and stored. A computer subsequently decodes the image, unscrambling the linear pixels into an angle-angle image at each time or range bin. We are left with a series of snapshots, each one depicting the portion of target surface in a given range bin. The pictures can be combined to form a 3-D realization of the target. Continuous recording of many images over a short time span is of use in imaging other transient phenomena. These applications share a need for multiple images from a nonrepeatable transient event of time duration on the order of nanoseconds. Applications discussed for the imager include (1) pulsed laser beam diagnostics -- measuring laser beam spatial and temporal structure, (2

  19. A Three-phase Unsymmetrical Distribution Power Flow Solution Based on Symmetrical Component Theory

    Directory of Open Access Journals (Sweden)

    Hongwei Li

    2017-12-01

    Full Text Available Aiming at the three-phase unsymmetrical distribution network, this paper proposed a threesequence components decoupled power flow method based on the node-branch incidence matrix. The three-sequence decoupled models were established based on symmetrical component theory by utilizing the weakly coupling feature of three-phase unsymmetrical distribution networks. The algorithm simplifies the complexity of the distribution network and reduces the dimensions of the matrix, so the calculation process is relatively simple. Moreover, a new approach deal with the PV nodes was developed based on the assumption that the positive-sequence voltage magnitude of PV node is sustained at a given fixed value. The formula to calculate the reactive power increment for each PV node was derived based on Thevenin equivalent circuit theory. The test results show that the proposed method and PV nodes processing approach have better convergence and faster calculating speed.

  20. A stable systemic risk ranking in China's banking sector: Based on principal component analysis

    Science.gov (United States)

    Fang, Libing; Xiao, Binqing; Yu, Honghai; You, Qixing

    2018-02-01

    In this paper, we compare five popular systemic risk rankings, and apply principal component analysis (PCA) model to provide a stable systemic risk ranking for the Chinese banking sector. Our empirical results indicate that five methods suggest vastly different systemic risk rankings for the same bank, while the combined systemic risk measure based on PCA provides a reliable ranking. Furthermore, according to factor loadings of the first component, PCA combined ranking is mainly based on fundamentals instead of market price data. We clearly find that price-based rankings are not as practical a method as fundamentals-based ones. This PCA combined ranking directly shows systemic risk contributions of each bank for banking supervision purpose and reminds banks to prevent and cope with the financial crisis in advance.

  1. Classification of geochemical data based on multivariate statistical analyses: Complementary roles of cluster, principal component, and independent component analyses

    Science.gov (United States)

    Iwamori, Hikaru; Yoshida, Kenta; Nakamura, Hitomi; Kuwatani, Tatsu; Hamada, Morihisa; Haraguchi, Satoru; Ueki, Kenta

    2017-03-01

    Identifying the data structure including trends and groups/clusters in geochemical problems is essential to discuss the origin of sources and processes from the observed variability of data. An increasing number and high dimensionality of recent geochemical data require efficient and accurate multivariate statistical analysis methods. In this paper, we show the relationship and complementary roles of k-means cluster analysis (KCA), principal component analysis (PCA), and independent component analysis (ICA) to capture the true data structure. When the data are preprocessed by primary standardization (i.e., with the zero mean and normalized by the standard deviation), KCA and PCA provide essentially the same results, although the former returns the solution in a discretized space. When the data are preprocessed by whitening (i.e., normalized by eigenvalues along the principal components), KCA and ICA may identify a set of independent trends and groups, irrespective of the amplitude (power) of variance. As an example, basalt isotopic compositions have been analyzed with KCA on the whitened data, demonstrating clear rock type/tectonic occurrence/mantle end-member discrimination. Therefore, the combination of these methods, particularly KCA on whitened data, is useful to capture and discuss the data structure of various geochemical systems, for which an Excel program is provided.

  2. Faults and fractures detection in 2D seismic data based on principal component analysis

    Directory of Open Access Journals (Sweden)

    Poorandokht Soltani

    2017-12-01

    Full Text Available Various approached have been introduced to extract as much as information form seismic image for any specific reservoir or geological study. Modeling of faults and fractures are among the most attracted objects for interpretation in geological study on seismic images that several strategies have been presented for this specific purpose. In this study, we have presented a modified approach of application concept of the principle components analysis to enhance faults and fractures from low quality seismic image. In the first step, relevant attributes considering imaging faults and fractures were have drawn based on vast study on previous successful applications of different attributes. Subsequently, major informative components of each attribute were defined by performing principle component analysis. Since random noise in seismic image exhibits no correlation in seismic data, true reflectors and diffraction events show high coherency value thus these objects would be separated into different orthogonal components in principle component analysis. It will make it easy to remove irrelevant information considering faults and fractures from seismic image and thus will make a higher quality image by combining attribute sections in principle component analysis. Afterwards, selected components were stacked to enhance the fault position in final image. However, since that are other geological objects that might show correlation in other orthogonal components, so there should be refinement step on the final image to stack only the favorable information. This approach was performed on a field land data example form north east of Iran. Result of application the proposed strategy shows that the method is capable to image faults compared to the conventional image analysis for fault detection. The method was also capable to image accurate position of the body of mud volcanoes exited in the image that could not be easily tracked by conventional seismic image

  3. Components and Outcomes of Internet-Based Interventions for Caregivers of Older Adults: Systematic Review

    OpenAIRE

    Guay, Cassioppée; Auger, Claudine; Demers, Louise; Mortenson, W Ben; Miller, William C; Gélinas-Bronsard, Dominique; Ahmed, Sara

    2017-01-01

    Background When trying to access interventions to improve their well-being and quality of life, family caregivers face many challenges. Internet-based interventions provide new and accessible opportunities to remotely support them and can contribute to reducing their burden. However, little is known about the link existing between the components, the use of behavior change techniques, and the outcomes of these Internet-based interventions. Objective This study aimed to provide an update on th...

  4. Independent component analysis based digital signal processing in coherent optical fiber communication systems

    Science.gov (United States)

    Li, Xiang; Luo, Ming; Qiu, Ying; Alphones, Arokiaswami; Zhong, Wen-De; Yu, Changyuan; Yang, Qi

    2018-02-01

    In this paper, channel equalization techniques for coherent optical fiber transmission systems based on independent component analysis (ICA) are reviewed. The principle of ICA for blind source separation is introduced. The ICA based channel equalization after both single-mode fiber and few-mode fiber transmission for single-carrier and orthogonal frequency division multiplexing (OFDM) modulation formats are investigated, respectively. The performance comparisons with conventional channel equalization techniques are discussed.

  5. Model Components of Mangrove Resources Management Based on Blue Economy Concept

    OpenAIRE

    Bidayani, Endang; Soemarno, Soemarno; Harahab, Nuddin; Rudianto, Rudianto

    2016-01-01

    This study was aimed at analyzing variables affecting mangrove resource conservation based on blue economy concept. The model component analysis applied Spearman Rank Correlation test. Result showed that Z-calc.was bigger than Z-tab. (1.64) at 95% confidence level, and therefore, Ho was rejected. This study concluded that resource efficiency, without wastes, social awareness, cyclic system of production, innovation and adaptation, and institution were blue economy concept-based variables. In ...

  6. Micro-electrolysis/retinervus luffae-based simultaneous autotrophic and heterotrophic denitrification for low C/N wastewater treatment.

    Science.gov (United States)

    Li, Jinlong; Li, Desheng; Cui, Yuwei; Xing, Wei; Deng, Shihai

    2017-07-01

    Nitrogen bioremediation in organic insufficient wastewater generally requires an extra carbon source. In this study, nitrate-contaminated wastewater was treated effectively through simultaneous autotrophic and heterotrophic denitrification based on micro-electrolysis carriers (MECs) and retinervus luffae fructus (RLF), respectively. The average nitrate and total nitrogen removal rates reached 96.3 and 94.0% in the MECs/RLF-based autotrophic and heterotrophic denitrification (MRAHD) system without ammonia and nitrite accumulation. The performance of MRAHD was better than that of MEC-based autotrophic denitrification for the wastewater treatment with low carbon nitrogen (COD/N) ratio. Real-time quantitative polymerase chain reaction (qPCR) revealed that the relative abundance of nirS-type denitrifiers attached to MECs (4.9%) and RLF (5.0%) was similar. Illumina sequencing suggested that the dominant genera were Thiobacillus (7.0%) and Denitratisoma (5.7%), which attached to MECs and RLF, respectively. Sulfuritalea was discovered as the dominant genus in the middle of the reactor. The synergistic interaction between autotrophic and heterotrophic denitrifiers played a vital role in the mixotrophic substrate environment.

  7. Simultaneous gains tuning in boiler/turbine PID-based controller clusters using iterative feedback tuning methodology.

    Science.gov (United States)

    Zhang, Shu; Taft, Cyrus W; Bentsman, Joseph; Hussey, Aaron; Petrus, Bryan

    2012-09-01

    Tuning a complex multi-loop PID based control system requires considerable experience. In today's power industry the number of available qualified tuners is dwindling and there is a great need for better tuning tools to maintain and improve the performance of complex multivariable processes. Multi-loop PID tuning is the procedure for the online tuning of a cluster of PID controllers operating in a closed loop with a multivariable process. This paper presents the first application of the simultaneous tuning technique to the multi-input-multi-output (MIMO) PID based nonlinear controller in the power plant control context, with the closed-loop system consisting of a MIMO nonlinear boiler/turbine model and a nonlinear cluster of six PID-type controllers. Although simplified, the dynamics and cross-coupling of the process and the PID cluster are similar to those used in a real power plant. The particular technique selected, iterative feedback tuning (IFT), utilizes the linearized version of the PID cluster for signal conditioning, but the data collection and tuning is carried out on the full nonlinear closed-loop system. Based on the figure of merit for the control system performance, the IFT is shown to deliver performance favorably comparable to that attained through the empirical tuning carried out by an experienced control engineer. Copyright © 2012 ISA. Published by Elsevier Ltd. All rights reserved.

  8. A green analytical method for the simultaneous analysis of cefixime trihydrate and ambroxol HCl based on ultraviolet derivative spectroscopy

    Directory of Open Access Journals (Sweden)

    Ceema Mathew

    2015-01-01

    Full Text Available Context: Until date, there is no reported derivative spectrophotometric method for the combination of cefixime trihydrate (CEF and ambroxol HCl (ABH. So an urgent need was felt to develop an ultraviolet (UV derivative spectroscopic method, which reduces the cost of analysis on comparing with high-performance liquid chromatography or high-performance thin layer chromatography method. Aims: To develop and validate an economical and ecofriendly derivative spectroscopic method that avoids the use of organic solvents for simultaneous quantification of both the drugs. Materials and Methods: A simple method based on the derivative spectrophotometric method at zero crossing wavelengths has been developed for the simultaneous quantification of CEF and ABH. As the method depends on hydrotropic dissolution, 0.1N urea is used as the solvent, and it yields an economical and ecofriendly method. Two wavelengths 253 nm (zero crossing point (ZCP for CEF and 306 nm (ZCP for ABH were selected for the quantification of ABH and CEF respectively. Results: The first derivative amplitude-concentration plots were linear over the range of 5-35 μg/ml and 3-10.5 μg/ml with detection limits of 0.187 and 0.0937 μg/ml and quantification limits of 0.625 and 0.312 μg/ml for CEF and ABH respectively. The percentage recovery was within the range between 99.05% and 102%. The % relative standard deviation for precision and accuracy of the method was found to be <2%. Conclusion: The proposed method was found to be simple, accurate and precise and can be successfully applied to the routine quality control analysis of studied drugs in their tablet formulations.

  9. A component-based approach to integrated modeling in the geosciences: The design of CSDMS

    Science.gov (United States)

    Peckham, Scott D.; Hutton, Eric W. H.; Norris, Boyana

    2013-04-01

    Development of scientific modeling software increasingly requires the coupling of multiple, independently developed models. Component-based software engineering enables the integration of plug-and-play components, but significant additional challenges must be addressed in any specific domain in order to produce a usable development and simulation environment that also encourages contributions and adoption by entire communities. In this paper we describe the challenges in creating a coupling environment for Earth-surface process modeling and the innovative approach that we have developed to address them within the Community Surface Dynamics Modeling System.

  10. Optimal pattern synthesis for speech recognition based on principal component analysis

    Science.gov (United States)

    Korsun, O. N.; Poliyev, A. V.

    2018-02-01

    The algorithm for building an optimal pattern for the purpose of automatic speech recognition, which increases the probability of correct recognition, is developed and presented in this work. The optimal pattern forming is based on the decomposition of an initial pattern to principal components, which enables to reduce the dimension of multi-parameter optimization problem. At the next step the training samples are introduced and the optimal estimates for principal components decomposition coefficients are obtained by a numeric parameter optimization algorithm. Finally, we consider the experiment results that show the improvement in speech recognition introduced by the proposed optimization algorithm.

  11. A Base Component for Network-Based Service-Oriented C4ISR Systems

    Science.gov (United States)

    2005-12-01

    access service. The main components of the service are given by two software modules, called front-end manager and service manager . A front-end...user, or by means of some installation wizard which downloads the most recent version from a designated network site. A service manager can be thought...of as a mediator between a front-end manager on the one hand and a set of network services on the other hand. A service manager is created by a

  12. Mixture Statistical Distribution Based Multiple Component Model for Target Detection in High Resolution SAR Imagery

    Directory of Open Access Journals (Sweden)

    Chu He

    2017-11-01

    Full Text Available This paper proposes an innovative Mixture Statistical Distribution Based Multiple Component (MSDMC model for target detection in high spatial resolution Synthetic Aperture Radar (SAR images. Traditional detection algorithms usually ignore the spatial relationship among the target’s components. In the presented method, however, both the structural information and the statistical distribution are considered to better recognize the target. Firstly, the method based on compressed sensing reconstruction is used to recover the SAR image. Then, the multiple component model composed of a root filter and some corresponding part filters is applied to describe the structural information of the target. In the following step, mixture statistical distributions are utilised to discriminate the target from the background, and the Method of Logarithmic Cumulants (MoLC based Expectation Maximization (EM approach is adopted to estimate the parameters of the mixture statistical distribution model, which will be finally merged into the proposed MSDMC framework together with the multiple component model. In the experiment, the aeroplanes and the electrical power towers in TerraSAR-X SAR images are detected at three spatial resolutions. The results indicate that the presented MSDMC Model has potential for improving the detection performance compared with the state-of-the-art SAR target detection methods.

  13. Component Cell-Based Restriction of Spectral Conditions and the Impact on CPV Module Power Rating

    Energy Technology Data Exchange (ETDEWEB)

    Muller, Matthew T [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Steiner, Marc [Fraunhofer Institute for Solar Energy Systems ISE; Siefer, Gerald [Fraunhofer Institute for Solar Energy Systems ISE; Bett, Andreas W. [Fraunhofer Institute for Solar Energy Systems ISE

    2018-01-26

    One approach to consider the prevailing spectral conditions when performing CPV module power ratings according to the standard IEC 62670-3 is based on spectral matching ratios (SMRs) determined by the means of component cell sensors. In this work, an uncertainty analysis of the SMR approach is performed based on a dataset of spectral irradiances created with SMARTS2. Using these illumination spectra, the respective efficiencies of multijunction solar cells with different cell architectures are calculated. These efficiencies were used to analyze the influence of different component cell sensors and SMR filtering methods. The 3 main findings of this work are as follows. First, component cells based on the lattice-matched triple-junction (LM3J) cell are suitable for restricting spectral conditions and are qualified for the standardized power rating of CPV modules - even if the CPV module is using multijunction cells other than LM3J. Second, a filtering of all 3 SMRs with +/-3.0% of unity results in the worst case scenario in an underestimation of -1.7% and overestimation of +2.4% compared to AM1.5d efficiency. Third, there is no benefit in matching the component cells to the module cell in respect to the measurement uncertainty.

  14. A Component-Based Modeling and Validation Method for PLC Systems

    Directory of Open Access Journals (Sweden)

    Rui Wang

    2014-05-01

    Full Text Available Programmable logic controllers (PLCs are complex embedded systems that are widely used in industry. This paper presents a component-based modeling and validation method for PLC systems using the behavior-interaction-priority (BIP framework. We designed a general system architecture and a component library for a type of device control system. The control software and hardware of the environment were all modeled as BIP components. System requirements were formalized as monitors. Simulation was carried out to validate the system model. A realistic example from industry of the gates control system was employed to illustrate our strategies. We found a couple of design errors during the simulation, which helped us to improve the dependability of the original systems. The results of experiment demonstrated the effectiveness of our approach.

  15. Software Engineering Environment for Component-based Design of Embedded Software

    DEFF Research Database (Denmark)

    Guo, Yu

    2010-01-01

    as well as application models in a computer-aided software engineering environment. Furthermore, component models have been realized following carefully developed design patterns, which provide for an efficient and reusable implementation. The components have been ultimately implemented as prefabricated......, validation, and executable code generation for specific hardware platforms. Developing such an environment and the associated tools is a highly complex engineering task. Therefore, this thesis has investigated key design issues and analysed existing platforms supporting model-driven software development...... software technology, which is largely based on informal design methods and manual coding techniques. That is why it is necessary to develop new design methods and tools that will eventually help improve existing practices. These considerations have motivated the development of the framework -- Component...

  16. Quantitative analysis of multiple components based on liquid chromatography with mass spectrometry in full scan mode.

    Science.gov (United States)

    Xu, Min Li; Li, Bao Qiong; Wang, Xue; Chen, Jing; Zhai, Hong Lin

    2016-08-01

    Although liquid chromatography with mass spectrometry in full scan mode can obtain all the signals simultaneously in a large range and low cost, it is rarely used in quantitative analysis due to several problems such as chromatographic drifts and peak overlap. In this paper, we propose a Tchebichef moment method for the simultaneous quantitative analysis of three active compounds in Qingrejiedu oral liquid based on three-dimensional spectra in full scan mode of liquid chromatography with mass spectrometry. After the Tchebichef moments were calculated directly from the spectra, the quantitative linear models for three active compounds were established by stepwise regression. All the correlation coefficients were more than 0.9978. The limits of detection and limits of quantitation were less than 0.11 and 0.49 μg/mL, respectively. The intra- and interday precisions were less than 6.54 and 9.47%, while the recovery ranged from 102.56 to 112.15%. Owing to the advantages of multi-resolution and inherent invariance properties, Tchebichef moments could provide favorable results even in the situation of peaks shifting and overlapping, unknown interferences and noise signals, so it could be applied to the analysis of three-dimensional spectra in full scan mode of liquid chromatography with mass spectrometry. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Striatal and Hippocampal Entropy and Recognition Signals in Category Learning: Simultaneous Processes Revealed by Model-Based fMRI

    Science.gov (United States)

    Davis, Tyler; Love, Bradley C.; Preston, Alison R.

    2012-01-01

    Category learning is a complex phenomenon that engages multiple cognitive processes, many of which occur simultaneously and unfold dynamically over time. For example, as people encounter objects in the world, they simultaneously engage processes to determine their fit with current knowledge structures, gather new information about the objects, and…

  18. MRI to X-ray mammography intensity-based registration with simultaneous optimisation of pose and biomechanical transformation parameters.

    Science.gov (United States)

    Mertzanidou, Thomy; Hipwell, John; Johnsen, Stian; Han, Lianghao; Eiben, Bjoern; Taylor, Zeike; Ourselin, Sebastien; Huisman, Henkjan; Mann, Ritse; Bick, Ulrich; Karssemeijer, Nico; Hawkes, David

    2014-05-01

    Determining corresponding regions between an MRI and an X-ray mammogram is a clinically useful task that is challenging for radiologists due to the large deformation that the breast undergoes between the two image acquisitions. In this work we propose an intensity-based image registration framework, where the biomechanical transformation model parameters and the rigid-body transformation parameters are optimised simultaneously. Patient-specific biomechanical modelling of the breast derived from diagnostic, prone MRI has been previously used for this task. However, the high computational time associated with breast compression simulation using commercial packages, did not allow the optimisation of both pose and FEM parameters in the same framework. We use a fast explicit Finite Element (FE) solver that runs on a graphics card, enabling the FEM-based transformation model to be fully integrated into the optimisation scheme. The transformation model has seven degrees of freedom, which include parameters for both the initial rigid-body pose of the breast prior to mammographic compression, and those of the biomechanical model. The framework was tested on ten clinical cases and the results were compared against an affine transformation model, previously proposed for the same task. The mean registration error was 11.6±3.8mm for the CC and 11±5.4mm for the MLO view registrations, indicating that this could be a useful clinical tool. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

  19. Multichannel wide-field microscopic FRET imaging based on simultaneous spectral unmixing of excitation and emission spectra.

    Science.gov (United States)

    DU, M; Mai, Z; Yang, F; Lin, F; Wei, L; Chen, T

    2018-01-01

    Simultaneous spectral unmixing of excitation and emission spectra (ExEm unmixing) has inherent ability resolving spectral crosstalks, two key issues of quantitative fluorescence resonance energy transfer (FRET) measurement, of both the excitation and emission spectra between donor and acceptor without additional corrections. We here set up a filter-based multichannel wide-field microscope for ExEm unmixing-based FRET imaging (m-ExEm-spFRET) containing a constant system correction factor (f sc ) for a stable system. We performed m-ExEm-spFRET with four- and two-wavelength excitation respectively on our system to quantitatively image single living cells expressing FRET tandem constructs, and obtained accurate FRET efficiency (E) and concentration ratio of acceptor to donor (R C ). We also performed m-ExEm-spFRET imaging for single living cells coexpressing CFP-Bax and YFP-Bax, and found that the E values were about 0 for control cells and about 28% for staurosporin-treated cells when R C were larger than 1, indicating that staurosporin induced significant oligomerisation. © 2017 The Authors Journal of Microscopy © 2017 Royal Microscopical Society.

  20. Implementation of intelligent nuclear material diagnosis module based on the component object model

    International Nuclear Information System (INIS)

    Lee, Sang Yoon; Song, Dae Yong; Ko, Won Il; Ha, Jang Ho; Kim, Ho Dong

    2003-08-01

    In this paper, the implementation techniques of intelligent nuclear material surveillance system based on the COM (Component Object Model) and SOM (Self Organized Mapping) was described. The surveillance system that is to be developed is consist of CCD cameras, neutron monitors, and PC for data acquisition. To develop the system, the properties of the COM based software development technology was investigated, and the characteristics of related platform APIs was summarized. This report could be used for the developers who want to develop the intelligent surveillance system for various experimental environments based on the DVR and sensors using Borland C++ Builder

  1. A Component-Based Vocabulary-Extensible Sign Language Gesture Recognition Framework

    Directory of Open Access Journals (Sweden)

    Shengjing Wei

    2016-04-01

    Full Text Available Sign language recognition (SLR can provide a helpful tool for the communication between the deaf and the external world. This paper proposed a component-based vocabulary extensible SLR framework using data from surface electromyographic (sEMG sensors, accelerometers (ACC, and gyroscopes (GYRO. In this framework, a sign word was considered to be a combination of five common sign components, including hand shape, axis, orientation, rotation, and trajectory, and sign classification was implemented based on the recognition of five components. Especially, the proposed SLR framework consisted of two major parts. The first part was to obtain the component-based form of sign gestures and establish the code table of target sign gesture set using data from a reference subject. In the second part, which was designed for new users, component classifiers were trained using a training set suggested by the reference subject and the classification of unknown gestures was performed with a code matching method. Five subjects participated in this study and recognition experiments under different size of training sets were implemented on a target gesture set consisting of 110 frequently-used Chinese Sign Language (CSL sign words. The experimental results demonstrated that the proposed framework can realize large-scale gesture set recognition with a small-scale training set. With the smallest training sets (containing about one-third gestures of the target gesture set suggested by two reference subjects, (82.6 ± 13.2% and (79.7 ± 13.4% average recognition accuracy were obtained for 110 words respectively, and the average recognition accuracy climbed up to (88 ± 13.7% and (86.3 ± 13.7% when the training set included 50~60 gestures (about half of the target gesture set. The proposed framework can significantly reduce the user’s training burden in large-scale gesture recognition, which will facilitate the implementation of a practical SLR system.

  2. Development of web-based integrity evaluation system for primary components in a nuclear power plant

    International Nuclear Information System (INIS)

    Lee, S.M.; Kim, J.C.; Choi, J.B.; Kim, Y.J.; Choi, S.N.; Jang, K.S.; Hong, S.Y.

    2004-01-01

    A nuclear power plant is composed of a number of primary components. Maintaining the integrity of these components is one of the most critical issues in nuclear industry. In order to maintain the integrity of these primary components, a complicated procedure is required including periodical in-service inspection, failure assessment, fracture mechanics analysis, etc. Also, experts in different fields have to co-operate to resolve the integrity issues on the basis of inspection results. This integrity evaluation process usually takes long, and thus, is detrimental for the plant productivity. Therefore, an effective safety evaluation system is essential to manage integrity issues on a nuclear power plant. In this paper, a web-based integrity evaluation system for primary components in a nuclear power plant is proposed. The proposed system, which is named as WEBIES (web-based integrity evaluation system), has been developed in the form of 3-tier system architecture. The system consists of three servers; application program server, user interface program server and data warehouse server. The application program server includes the defect acceptance analysis module and the fracture mechanics analysis module which are programmed on the basis of ASME sec. XI, appendix A. The data warehouse server provides data for the integrity evaluation including material properties, geometry information, inspection data and stress data. The user interface program server provides information to all co- workers in the field of integrity evaluation. The developed system provides engineering knowledge-based information and concurrent and collaborative working environment through internet, and thus, is expected to raise the efficiency of integrity evaluation procedures on primary components of a nuclear power plant. (orig.)

  3. Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting.

    Science.gov (United States)

    Weckle, Amy; Aiello, Allison E; Uddin, Monica; Galea, Sandro; Coulborn, Rebecca M; Soliven, Richelo; Meier, Helen; Wildman, Derek E

    2015-11-30

    Collection and processing of whole blood samples in a non-clinical setting offers a unique opportunity to evaluate community-dwelling individuals both with and without preexisting conditions. Rapid processing of these samples is essential to avoid degradation of key cellular components. Included here are methods for simultaneous peripheral blood mononuclear cell (PBMC), DNA, RNA and serum isolation from a single blood draw performed in the homes of consenting participants across a metropolitan area, with processing initiated within 2 hr of collection. We have used these techniques to process over 1,600 blood specimens yielding consistent, high quality material, which has subsequently been used in successful DNA methylation, genotyping, gene expression and flow cytometry analyses. Some of the methods employed are standard; however, when combined in the described manner, they enable efficient processing of samples from participants of population- and/or community-based studies who would not normally be evaluated in a clinical setting. Therefore, this protocol has the potential to obtain samples (and subsequently data) that are more representative of the general population.

  4. Simultaneous multi-vehicle detection and tracking framework with pavement constraints based on machine learning and particle filter algorithm

    Science.gov (United States)

    Wang, Ke; Huang, Zhi; Zhong, Zhihua

    2014-11-01

    Due to the large variations of environment with ever-changing background and vehicles with different shapes, colors and appearances, to implement a real-time on-board vehicle recognition system with high adaptability, efficiency and robustness in complicated environments, remains challenging. This paper introduces a simultaneous detection and tracking framework for robust on-board vehicle recognition based on monocular vision technology. The framework utilizes a novel layered machine learning and particle filter to build a multi-vehicle detection and tracking system. In the vehicle detection stage, a layered machine learning method is presented, which combines coarse-search and fine-search to obtain the target using the AdaBoost-based training algorithm. The pavement segmentation method based on characteristic similarity is proposed to estimate the most likely pavement area. Efficiency and accuracy are enhanced by restricting vehicle detection within the downsized area of pavement. In vehicle tracking stage, a multi-objective tracking algorithm based on target state management and particle filter is proposed. The proposed system is evaluated by roadway video captured in a variety of traffics, illumination, and weather conditions. The evaluating results show that, under conditions of proper illumination and clear vehicle appearance, the proposed system achieves 91.2% detection rate and 2.6% false detection rate. Experiments compared to typical algorithms show that, the presented algorithm reduces the false detection rate nearly by half at the cost of decreasing 2.7%-8.6% detection rate. This paper proposes a multi-vehicle detection and tracking system, which is promising for implementation in an on-board vehicle recognition system with high precision, strong robustness and low computational cost.

  5. Hyoid myotomy and suspension without simultaneous palate or tongue base surgery for obstructive sleep apnea

    Directory of Open Access Journals (Sweden)

    Adrian A. Ong

    2017-06-01

    Full Text Available Objective: Determine the effects of hyoid myotomy and suspension (HMS without concurrent palatal or tongue base sleep surgery for obstructive sleep apnea (OSA. Method: Patients with OSA treated with HMS were identified using CPT code (21685 at an academic and private sleep surgery clinic. Those who underwent concurrent palatal or tongue base sleep surgery were excluded. Outcomes included simultaneous procedures, apnea-hypopnea index (AHI, lowest oxyhemoglobin saturation (LSAT, and Epworth Sleepiness Scale (ESS. Results: Nineteen patients with OSA underwent HMS without palatal or tongue base sleep surgery. The average age at surgery was (55.3 ± 13.5 years with a majority of patients being male (71%. Concurrent procedures included the following: torus mandibularis excision (n = 1, endoscopic sinus surgery (n = 4, septoplasty (n = 10, inferior turbinate reduction (n = 12, and nasal valve repair (n = 2. AHI improved significantly from (39.7 ± 21.2 events/h to (22.6 ± 22.7 events/h after HMS (P  30 events/h had an improvement in AHI from (49.9 ± 16.6 events/h to (29.1 ± 24.9 events/h, P < 0.01. Conclusion: HMS without palatal or tongue base sleep surgery improves OSA severity. It can be considered as a valid option in the treatment of OSA in appropriately-selected patients. Keywords: Obstructive sleep apnea, Hyoid myotomy and suspension, AirLift system

  6. Independent component analysis-based source-level hyperlink analysis for two-person neuroscience studies

    Science.gov (United States)

    Zhao, Yang; Dai, Rui-Na; Xiao, Xiang; Zhang, Zong; Duan, Lian; Li, Zheng; Zhu, Chao-Zhe

    2017-02-01

    Two-person neuroscience, a perspective in understanding human social cognition and interaction, involves designing immersive social interaction experiments as well as simultaneously recording brain activity of two or more subjects, a process termed "hyperscanning." Using newly developed imaging techniques, the interbrain connectivity or hyperlink of various types of social interaction has been revealed. Functional near-infrared spectroscopy (fNIRS)-hyperscanning provides a more naturalistic environment for experimental paradigms of social interaction and has recently drawn much attention. However, most fNIRS-hyperscanning studies have computed hyperlinks using sensor data directly while ignoring the fact that the sensor-level signals contain confounding noises, which may lead to a loss of sensitivity and specificity in hyperlink analysis. In this study, on the basis of independent component analysis (ICA), a source-level analysis framework is proposed to investigate the hyperlinks in a fNIRS two-person neuroscience study. The performance of five widely used ICA algorithms in extracting sources of interaction was compared in simulative datasets, and increased sensitivity and specificity of hyperlink analysis by our proposed method were demonstrated in both simulative and real two-person experiments.

  7. Blind Separation of Acoustic Signals Combining SIMO-Model-Based Independent Component Analysis and Binary Masking

    Directory of Open Access Journals (Sweden)

    Hiekata Takashi

    2006-01-01

    Full Text Available A new two-stage blind source separation (BSS method for convolutive mixtures of speech is proposed, in which a single-input multiple-output (SIMO-model-based independent component analysis (ICA and a new SIMO-model-based binary masking are combined. SIMO-model-based ICA enables us to separate the mixed signals, not into monaural source signals but into SIMO-model-based signals from independent sources in their original form at the microphones. Thus, the separated signals of SIMO-model-based ICA can maintain the spatial qualities of each sound source. Owing to this attractive property, our novel SIMO-model-based binary masking can be applied to efficiently remove the residual interference components after SIMO-model-based ICA. The experimental results reveal that the separation performance can be considerably improved by the proposed method compared with that achieved by conventional BSS methods. In addition, the real-time implementation of the proposed BSS is illustrated.

  8. Components and Outcomes of Internet-Based Interventions for Caregivers of Older Adults: Systematic Review.

    Science.gov (United States)

    Guay, Cassioppée; Auger, Claudine; Demers, Louise; Mortenson, W Ben; Miller, William C; Gélinas-Bronsard, Dominique; Ahmed, Sara

    2017-09-19

    When trying to access interventions to improve their well-being and quality of life, family caregivers face many challenges. Internet-based interventions provide new and accessible opportunities to remotely support them and can contribute to reducing their burden. However, little is known about the link existing between the components, the use of behavior change techniques, and the outcomes of these Internet-based interventions. This study aimed to provide an update on the best available evidence about the efficacy of Internet-based interventions for caregivers of older adults. Specifically, the components and the use of behavior change techniques and how they impact on the efficacy of the intervention were sought. A systematic review searched primary source studies published between 2000 and 2015. Included studies were scored with a high level of evidence by independent raters using the GRADE criteria and reported caregiver-specific outcomes about interventions delivered through the Internet for caregivers of people aged 50 years and older. A narrative synthesis identified intervention components (eg, content, multimedia use, interactive online activities, and provision of support), behavior change techniques, and caregiver outcomes (eg, effects on stressors, mediators, and psychological health). The risk of bias within the included studies was assessed. A total of 2338 articles were screened and 12 studies describing 10 Internet-based interventions were identified. Seven of these interventions led to statistically significant improvements in caregiver outcomes (eg, reducing depression or anxiety, n=4). These efficacious interventions used interactive components, such as online exercises and homework (n=4) or questionnaires on health status (n=2) and five of them incorporated remote human support, either by professionals or peers. The most frequently used behavior change techniques included in efficacious interventions were provision of social support (n=6) and

  9. Risk-based management of remaining life of power plant components

    International Nuclear Information System (INIS)

    Roos, E.; Jovanovic, A.S.; Maile, K.; Auerkari, P.

    1999-01-01

    The paper describes application of different modules of the MPA-System ALIAS in risk-based management of remaining life of power plant components. The system allows comprehensive coverage of all aspects of the remaining life management, including also the risk analysis and risk management. In addition, thanks to the modular character of the system it is also possible to implement new methods: In the case described here, a new (probabilistic) method for determination of the next inspection time for the components exposed to creep loading has been developed and implemented in the system. Practical application of the method has shown (a) that the mean values obtained by the method fall into the range of results obtained by other methods (based on expert knowledge), and (b) that it is possible to quantify the probability of aberration from the mean values. This in turn allows quantifying the additional risks linked to e.g. prolonging of inspection intervals. (orig.) [de

  10. Spectral network based on component cells under the SOPHIA European project

    Energy Technology Data Exchange (ETDEWEB)

    Núñez, Rubén, E-mail: ruben.nunez@ies-def.upm.es; Antón, Ignacio; Askins, Steve; Sala, Gabriel [Instituto de Energía Solar - Universidad Politécnica de Madrid, Ciudad Universitaria, 28040 Madrid (Spain); Domínguez, César; Voarino, Philippe [CEA-INES, 50 avenue du Lac Léman, 73375 Le Bourget-du-Lac (France); Steiner, Marc; Siefer, Gerald [Fraunhofer ISE, Heidenhofstr. 2, 79110 Freiburg (Germany); Fucci, Rafaelle; Roca, Franco [ENEA, P.le E.Fermi 1, Località Granatello, 80055 Portici (Italy); Minuto, Alessandro; Morabito, Paolo [RSE, Via Rubattino 54, 20134 Milan (Italy)

    2015-09-28

    In the frame of the European project SOPHIA, a spectral network based on component (also called isotypes) cells has been created. Among the members of this project, several spectral sensors based on component cells and collimating tubes, so-called spectroheliometers, were installed in the last years, allowing the collection of minute-resolution spectral data useful for CPV systems characterization across Europe. The use of spectroheliometers has been proved useful to establish the necessary spectral conditions to perform power rating of CPV modules and systems. If enough data in a given period of time is collected, ideally a year, it is possible to characterize spectrally the place where measurements are taken, in the same way that hours of annual irradiation can be estimated using a pyrheliometer.

  11. Hybrid dimensionality reduction method based on support vector machine and independent component analysis.

    Science.gov (United States)

    Moon, Sangwoo; Qi, Hairong

    2012-05-01

    This paper presents a new hybrid dimensionality reduction method to seek projection through optimization of both structural risk (supervised criterion) and data independence (unsupervised criterion). Classification accuracy is used as a metric to evaluate the performance of the method. By minimizing the structural risk, projection originated from the decision boundaries directly improves the classification performance from a supervised perspective. From an unsupervised perspective, projection can also be obtained based on maximum independence among features (or attributes) in data to indirectly achieve better classification accuracy over more intrinsic representation of the data. Orthogonality interrelates the two sets of projections such that minimum redundancy exists between the projections, leading to more effective dimensionality reduction. Experimental results show that the proposed hybrid dimensionality reduction method that satisfies both criteria simultaneously provides higher classification performance, especially for noisy data sets, in relatively lower dimensional space than various existing methods.

  12. A population-based study of animal component sensitization, asthma, and rhinitis in schoolchildren.

    Science.gov (United States)

    Bjerg, Anders; Winberg, Anna; Berthold, Malin; Mattsson, Lars; Borres, Magnus P; Rönmark, Eva

    2015-09-01

    Animal sensitization is a major determinant of asthma in children. Component-resolved studies of unselected pediatric populations are lacking. The aim was to describe sensitization to animal components and the association with asthma and rhinitis in animal-sensitized schoolchildren. A random sample of 696 children (11-12 years) from a Swedish population-based cohort was tested for sensitization to cat, dog, and horse dander using ImmunoCAP. Sera from animal-sensitized children were further analyzed by microarray including three allergen components from cat, four from dog, and two from horse. The parents completed an expanded ISAAC questionnaire. Of 259 animal-sensitized children (≥0.1 kUA /l), 51% were sensitized to all three, 23% to two, and 25% to one species. Current asthma and asthma symptoms following contact with cats were associated with co-sensitization to Fel d 1 and Fel d 4. This association was seen already at moderate-level sensitization (1-15 ISU) to Fel d 4, at which level most children were sensitized to Fel d 1, as well. In dog-sensitized children, the majority was sensitized to more than one dog component, and co-sensitization to Can f 5 and Can f 1/f 2 conferred the greatest risk for asthma. Sensitization to the highly cross-reactive serum albumins was uncommon and not associated with asthma. Among schoolchildren in northern Sweden, where mite allergy is uncommon, furry animals were the primary perennial sensitizers. Asthma was associated with higher levels of component sensitization, and sensitization to more than one component from the same animal conferred the greatest risk. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  13. Software Engineering of Component-Based Systems-of-Systems: A Reference Framework

    OpenAIRE

    Loiret, Frédéric; Rouvoy, Romain; Seinturier, Lionel; Merle, Philippe

    2011-01-01

    CORE A.; International audience; Systems-of-Systems (SoS) are complex infrastructures, which are characterized by a wide diversity of technologies and requirements imposed by the domain(s) they target. In this context, the software engineering community has been focusing on assisting the developers by providing them domain-specific languages, component-based software engineering frameworks and tools to leverage on the design and the development of such systems. However, the adoption of such a...

  14. Prototypic implementations of the building block for component based open Hypermedia systems (BB/CB-OHSs)

    DEFF Research Database (Denmark)

    Mohamed, Omer I. Eldai

    2005-01-01

    In this paper we describe the prototypic implementations of the BuildingBlock (BB/CB-OHSs) that proposed to address some of the Component-based Open Hypermedia Systems (CB-OHSs) issues, including distribution and interoperability [4, 11, 12]. Four service implementations were described below....... These are the math service, navigational service, naming and location service and the storage service in addition to two communication protocols (TCP/IP and JAVA RMI)....

  15. Development of a component centered fault monitoring and diagnosis knowledge based system for space power system

    Science.gov (United States)

    Lee, S. C.; Lollar, Louis F.

    1988-01-01

    The overall approach currently being taken in the development of AMPERES (Autonomously Managed Power System Extendable Real-time Expert System), a knowledge-based expert system for fault monitoring and diagnosis of space power systems, is discussed. The system architecture, knowledge representation, and fault monitoring and diagnosis strategy are examined. A 'component-centered' approach developed in this project is described. Critical issues requiring further study are identified.

  16. [Determination of film thickness, component and content based on glass surface by using XRF spectrometry].

    Science.gov (United States)

    Mei, Yan; Ma, Mi-Xia; Nie, Zuo-Ren

    2013-12-01

    Film thickness, component and content based on glass surface were determined by using XRF technic, measure condition and instrument work condition in every layer were set and adjusted for the best measure effect for every element. Background fundamental parameter (BG-FP) method was built up. Measure results with this method were consistent with the actual preparation course and the method could fit to production application.

  17. Initial development of PC software base for the design of electromagnetic component in accelerator

    International Nuclear Information System (INIS)

    Zhang Tianjue; Fan Mingwu; Zhang Manhuai; Huang Jijie; Dai Xiaoming; Chu Chengjie

    2000-01-01

    The initial development of PC software base for the design of electromagnetic component in accelerator is described. The developing studies include the transplantation and development of POISSON/SUPERFISH, RELAX 3D, TRANSPORT, RAYTRACE, MAD and PARMELA, and the modification of software DE2D, DE3D, CYCCAE and CYCCEN, which are developed in China Institute of Atomic Energy. Some application in the actual engineering is also introduced

  18. EON: a component-based approach to automation of protocol-directed therapy.

    OpenAIRE

    Musen, M A; Tu, S W; Das, A K; Shahar, Y

    1996-01-01

    Provision of automated support for planning protocol-directed therapy requires a computer program to take as input clinical data stored in an electronic patient-record system and to generate as output recommendations for therapeutic interventions and laboratory testing that are defined by applicable protocols. This paper presents a synthesis of research carried out at Stanford University to model the therapy-planning task and to demonstrate a component-based architecture for building protocol...

  19. A multi-agent-based component control and energy management system for electric vehicles

    OpenAIRE

    Isermann, Timo

    2016-01-01

    This dissertation introduces a new approach to electric vehicle (EV) energy and power management as well as vehicle component control based on multi-agent technology to solve technologically and historically conditioned challenges of EVs by increasing their usability, flexibility, and resilience. Today’s EVs have reduced driving ranges and comfort fitments compared to similar combustion powered vehicles. Limited battery sizes and capacities, originating from the high costs of the battery syst...

  20. An Intuitionistic Fuzzy Methodology for Component-Based Software Reliability Optimization

    DEFF Research Database (Denmark)

    Madsen, Henrik; Grigore, Albeanu; Popenţiuvlǎdicescu, Florin

    2012-01-01

    Component-based software development is the current methodology facilitating agility in project management, software reuse in design and implementation, promoting quality and productivity, and increasing the reliability and performability. This paper illustrates the usage of intuitionistic fuzzy...... degree approach in modelling the quality of entities in imprecise software reliability computing in order to optimize management results. Intuitionistic fuzzy optimization algorithms are proposed to be used for complex software systems reliability optimization under various constraints....

  1. Optimal allocation of selected T-series advanced base functional component equipment packages

    OpenAIRE

    Weitz, Jeffrey D.

    2000-01-01

    Advanced Base Functional Components (ABFCs) are pre-planned modular units of equipment and personnel designed to extend or create the logistic infrastructure required to support naval expeditionary operations. The ABFC program is structured to combine trained personnel with the equipment needed to perform a particular logistic mission such as seaport operations and cargo handling, warehousing, or freight terminal operations. If the ABFC must deploy to a theater of operations, individual equip...

  2. NONLINEAR OPTICAL PHENOMENA: Multiwave generation of the Stokes components in lasers with an SRS self-converter based on an Nd3+:KGd(WO4)2 crystal

    Science.gov (United States)

    Gulin, A. V.; Narkhova, G. I.; Ustimenko, N. S.

    1998-09-01

    An experimental investigation was made of multi- wave generation of radiation pulses of ~ 5 ns duration in lasers with a self-converter based on stimulated Raman scattering in an Nd3+:KGd(WO4)2 crystal. The efficiency of conversion to the first Stokes component with the wavelength 1.18 μm was about 70% and simultaneous generation was possible at three wavelengths (1.067, 1.18, and 1.32 μm), each with the same intensity. Simultaneous generation of 14 wavelengths was observed.

  3. Simultaneous optimization of beam orientations, wedge filters and field weights for inverse planning with anatomy-based MLC fields

    International Nuclear Information System (INIS)

    Beaulieu, Frederic; Beaulieu, Luc; Tremblay, Daniel; Roy, Rene

    2004-01-01

    As an alternative between manual planning and beamlet-based IMRT, we have developed an optimization system for inverse planning with anatomy-based MLC fields. In this system, named Ballista, the orientation (table and gantry), the wedge filter and the field weights are simultaneously optimized for every beam. An interesting feature is that the system is coupled to Pinnacle3 by means of the PinnComm interface, and uses its convolution dose calculation engine. A fully automatic MLC segmentation algorithm is also included. The plan evaluation is based on a quasi-random sampling and on a quadratic objective function with penalty-like constraints. For efficiency, optimal wedge angles and wedge orientations are determined using the concept of the super-omni wedge. A bound-constrained quasi-Newton algorithm performs field weight optimization, while a fast simulated annealing algorithm selects the optimal beam orientations. Moreover, in order to generate directly deliverable plans, the following practical considerations have been incorporated in the system: collision between the gantry and the table as well as avoidance of the radio-opaque elements of a table top. We illustrate the performance of the new system on two patients. In a rhabdomyosarcoma case, the system generated plans improving both the target coverage and the sparing of the parotide, as compared to a manually designed plan. In the second case presented, the system successfully produced an adequate plan for the treatment of the prostate while avoiding both hip prostheses. For the many cases where full IMRT may not be necessary, the system efficiently generates satisfactory plans meeting the clinical objectives, while keeping the treatment verification much simpler

  4. Simultaneous determination of ribavirin and ribavirin base in monkey plasma by high performance liquid chromatography with tandem mass spectrometry.

    Science.gov (United States)

    Li, Wenkui; Luo, Suyi; Li, Shaoyong; Athill, Lawrence; Wu, Amy; Ray, Tapan; Zhou, Wei; Ke, June; Smith, Harold T; Tse, Francis L S

    2007-02-01

    For the first time, a liquid chromatographic method with tandem mass spectrometric detection (LC-MS/MS) for the simultaneous determination of ribavirin and rabavirin base was developed and validated over the concentration range of 10-5,000 ng/ml, respectively, using a 0.025 ml monkey plasma sample. Ribavirin, ribavirin base, and the internal standards were extracted from monkey plasma via protein precipitation. After evaporation of the supernatant, the extract was reconstituted with 5% methanol (containing 0.1% formic acid) and injected onto the LC-MS/MS system. Optimum chromatographic separation was achieved on a Waters Atlantis dc18 (150 mm x 2.1mm, 5 microm) column with mobile phase run in gradient with 100% water containing 0.5% formic acid (A) and 90% acetonitrile (containing 0.5% formic acid (B). The flow rate was 0.4-0.6 ml/min with total cycle time of approximately 7.0 min. Post-column addition of acetonitrile (containing 0.1% formic acid) at 0.3 ml/min was used to increase the ionization efficiency in the MS source. The method was validated for sensitivity, linearity, reproducibility, stability and recovery. Lack of adverse matrix effect and carry-over was also demonstrated. The intra-day and inter-day precision and accuracy of the quality control (QC) samples were <9.0% relative standard deviation (R.S.D.) and 10.8% bias for ribavirin, and 10.3% R.S.D. and 11.3% bias for ribavirin base. The current specific, accurate and precise assay is useful in support of the toxicokinetic and pharmacokinetic studies of these compounds.

  5. Age estimation in forensic anthropology: quantification of observer error in phase versus component-based methods.

    Science.gov (United States)

    Shirley, Natalie R; Ramirez Montes, Paula Andrea

    2015-01-01

    The purpose of this study was to assess observer error in phase versus component-based scoring systems used to develop age estimation methods in forensic anthropology. A method preferred by forensic anthropologists in the AAFS was selected for this evaluation (the Suchey-Brooks method for the pubic symphysis). The Suchey-Brooks descriptions were used to develop a corresponding component-based scoring system for comparison. Several commonly used reliability statistics (kappa, weighted kappa, and the intraclass correlation coefficient) were calculated to assess observer agreement between two observers and to evaluate the efficacy of each of these statistics for this study. The linear weighted kappa was determined to be the most suitable measure of observer agreement. The results show that a component-based system offers the possibility for more objective scoring than a phase system as long as the coding possibilities for each trait do not exceed three states of expression, each with as little overlap as possible. © 2014 American Academy of Forensic Sciences.

  6. Selection of Component Codes for Turbo Coding Based on Convergence properties

    DEFF Research Database (Denmark)

    Andersen, Jakob Dahl

    1999-01-01

    The turbo decoding is a sub-optimal decoding, i.e. it is not a maximum likelihood decoding. It is important to be aware of this fact when the parameters for the scheme are chosen. This goes especially for the selection of component codes, where the selection often has been based solely on the per......The turbo decoding is a sub-optimal decoding, i.e. it is not a maximum likelihood decoding. It is important to be aware of this fact when the parameters for the scheme are chosen. This goes especially for the selection of component codes, where the selection often has been based solely...... on the performance at high SNR's. We will show that it is important to base the choice on the performance at low SNR's, i.e. the convergence properties, as well. Further, the study of the performance with different component codes may lead to an understanding of the convergence process in the turbo codes....

  7. Simultaneous All-Optical Demultiplexing and Regeneration of a Channel from a 40 Gbit/s OTDM Signals Based on SPM and XPM in Dispersion Shifted Fiber

    DEFF Research Database (Denmark)

    Yu, Jianjun; Jeppesen, Palle

    2000-01-01

    A new method for simultaneous demultiplexing and regeneration of a channel from a 40 Gbit/s OTDM signal is proposed and experimentally verified. The method is based on self-phase and cross-phase modulation in a dispersion shifted fiber.......A new method for simultaneous demultiplexing and regeneration of a channel from a 40 Gbit/s OTDM signal is proposed and experimentally verified. The method is based on self-phase and cross-phase modulation in a dispersion shifted fiber....

  8. Real-time and encryption efficiency improvements of simultaneous fusion, compression and encryption method based on chaotic generators

    Science.gov (United States)

    Jridi, Maher; Alfalou, Ayman

    2018-03-01

    In this paper, enhancement of an existing optical simultaneous fusion, compression and encryption (SFCE) scheme in terms of real-time requirements, bandwidth occupation and encryption robustness is proposed. We have used and approximate form of the DCT to decrease the computational resources. Then, a novel chaos-based encryption algorithm is introduced in order to achieve the confusion and diffusion effects. In the confusion phase, Henon map is used for row and column permutations, where the initial condition is related to the original image. Furthermore, the Skew Tent map is employed to generate another random matrix in order to carry out pixel scrambling. Finally, an adaptation of a classical diffusion process scheme is employed to strengthen security of the cryptosystem against statistical, differential, and chosen plaintext attacks. Analyses of key space, histogram, adjacent pixel correlation, sensitivity, and encryption speed of the encryption scheme are provided, and favorably compared to those of the existing crypto-compression system. The proposed method has been found to be digital/optical implementation-friendly which facilitates the integration of the crypto-compression system on a very broad range of scenarios.

  9. Simultaneous methane production and wastewater reuse by a membrane-based process: Evaluation with raw domestic wastewater

    International Nuclear Information System (INIS)

    Gao Dawen; An Rui; Tao Yu; Li Jin; Li Xinxin; Ren Nanqi

    2011-01-01

    In this study, a membrane-based process was applied to simultaneously reclaim methane and generate reused water from raw domestic wastewater. The system was comprised of up-flow anaerobic sludge fixed bed (UAFB), anoxic sink (AS) and aerobic membrane bioreactor (MBR). The hydraulic retention time of UAFB (HRT U ) was gradually shortened from 8 h to 6 h, 3 h and to 1 h, while the HRT of AS and MBR kept at 8 h. It is found that HRT U of 3 h was more suitable for the balancing production of biogas and volatile fatty acids (VFAs), and the VFAs served as carbon source for denitrification. The trans-membrane pressure (TMP) of the MBR kept lower than 0.04 MPa without wash or change of membrane sheet, however, the scanning electron microscopy (SEM) analysis indicated that microbes attached to the inner-surface of membrane, causing irreversible fouling after 133-day operation. The denaturing gradient gel electrophoresis (DGGE) profiles of amplified 16S rDNA gene fragments proved that more functional bacteria and higher microbial diversity emerged at HRT U of 3 h and 1 h. Most bacteria belonged to Betaproteobacteria and were responsible for carbon and nitrogen removal.

  10. Improvement of ozone forecast over Beijing based on ensemble Kalman filter with simultaneous adjustment of initial conditions and emissions

    Directory of Open Access Journals (Sweden)

    X. Tang

    2011-12-01

    Full Text Available In order to improve the surface ozone forecast over Beijing and surrounding regions, data assimilation method integrated into a high-resolution regional air quality model and a regional air quality monitoring network are employed. Several advanced data assimilation strategies based on ensemble Kalman filter are designed to adjust O3 initial conditions, NOx initial conditions and emissions, VOCs initial conditions and emissions separately or jointly through assimilating ozone observations. As a result, adjusting precursor initial conditions demonstrates potential improvement of the 1-h ozone forecast almost as great as shown by adjusting precursor emissions. Nevertheless, either adjusting precursor initial conditions or emissions show deficiency in improving the short-term ozone forecast at suburban areas. Adjusting ozone initial values brings significant improvement to the 1-h ozone forecast, and its limitations lie in the difficulty in improving the 1-h forecast at some urban site. A simultaneous adjustment of the above five variables is found to be able to reduce these limitations and display an overall better performance in improving both the 1-h and 24-h ozone forecast over these areas. The root mean square errors of 1-h ozone forecast at urban sites and suburban sites decrease by 51% and 58% respectively compared with those in free run. Through these experiments, we found that assimilating local ozone observations is determinant for ozone forecast over the observational area, while assimilating remote ozone observations could reduce the uncertainty in regional transport ozone.

  11. Simultaneous Enhancement of Efficiency and Stability of Phosphorescent OLEDs Based on Efficient Förster Energy Transfer from Interface Exciplex.

    Science.gov (United States)

    Zhang, Dongdong; Cai, Minghan; Zhang, Yunge; Bin, Zhengyang; Zhang, Deqiang; Duan, Lian

    2016-02-17

    Exciplex forming cohosts have been widely adopted in phosphorescent organic light-emitting diodes (PHOLEDs), achieving high efficiency with low roll-off and low driving voltage. However, the influence of the exciplex-forming hosts on the lifetimes of the devices, which is one of the essential characteristics, remains unclear. Here, we compare the influence of the bulk exciplex and interface exciplex on the performances of the devices, demonstrating highly efficient orange PHOLEDs with long lifetime at low dopant concentration by efficient Förster energy transfer from the interface exciplex. A bipolar host, (3'-(4,6-diphenyl-1,3,5-triazin-2-yl)-(1,1'-biphenyl)-3-yl)-9-carbazole (CzTrz), was adopted to combine with a donor molecule, tris(4-(9H-carbazol-9-yl)phenyl)amine (TCTA), to form exciplex. Devices with energy transfer from the interface exciplex achieve lifetime almost 2 orders of magnitude higher than the ones based on bulk exciplex as the host by avoiding the formation of the donor excited states. Moreover, a highest EQE of 27% was obtained at the dopant concentration as low as 3 wt % for a device with interface exciplex, which is favorable for reducing the cost of fabrication. We believe that our work may shed light on future development of ideal OLEDs with high efficiency, long-lifetime, low roll-off and low cost simultaneously.

  12. Chitosan-based nanocomplexes for simultaneous loading, burst reduction and controlled release of doxorubicin and 5-fluorouracil.

    Science.gov (United States)

    Di Martino, Antonio; Kucharczyk, Pavel; Capakova, Zdenka; Humpolicek, Petr; Sedlarik, Vladimir

    2017-09-01

    In this work, nanocomplexes based on chitosan grafted by carboxy-modified polylactic acid (SPLA) were prepared with the aim of loading simultaneously two anticancer drugs - doxorubicin and 5-fluorouracil, as well as to control their release, reduce the initial burst and boost cytotoxicity. The SPLA was prepared by a polycondensation reaction, using pentetic acid as the core molecule, and linked to the chitosan backbone through a coupling reaction. Nanocomplexes loaded with both drugs were formulated by the polyelectrolyte complexation method. The structure of the SPLA was characterized by 1 H NMR, while the product CS-SPLA was analyzed by FTIR-ATR to prove the occurrence of the reaction. Results showed that the diameters and ζ-potential of the nanocomplexes fall in the range 120-200nm and 20-37mV, respectively. SEM and TEM analysis confirmed the spherical shape and dimensions of the nanocomplexes. The presence of hydrophobic side chain SPLA did not influence the encapsulation efficiency of the drugs but strongly reduced the initial burst and prolonged release over time compared to unmodified chitosan. MS analysis showed that no degradation or interactions between the drugs and carrier were exhibited after loading or 24h of release had taken place, confirming the protective role of the nanocomplexes. In vitro tests demonstrated an increase in the cytotoxicity of the drugs when loaded in the prepared carriers. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  13. Simultaneous Determination of the Main Peanut Allergens in Foods Using Disposable Amperometric Magnetic Beads-Based Immunosensing Platforms

    Directory of Open Access Journals (Sweden)

    Víctor Ruiz-Valdepeñas Montiel

    2016-06-01

    Full Text Available In this work, a novel magnetic beads (MBs-based immunosensing approach for the rapid and simultaneous determination of the main peanut allergenic proteins (Ara h 1 and Ara h 2 is reported. It involves the use of sandwich-type immunoassays using selective capture and detector antibodies and carboxylic acid-modified magnetic beads (HOOC-MBs. Amperometric detection at −0.20 V was performed using dual screen-printed carbon electrodes (SPdCEs and the H2O2/hydroquinone (HQ system. This methodology exhibits high sensitivity and selectivity for the target proteins providing detection limits of 18.0 and 0.07 ng/mL for Ara h 1 and Ara h 2, respectively, with an assay time of only 2 h. The usefulness of the approach was evaluated by detecting the endogenous content of both allergenic proteins in different food extracts as well as trace amounts of peanut allergen (0.0001% or 1.0 mg/kg in wheat flour spiked samples. The developed platform provides better Low detection limits (LODs in shorter assay times than those claimed for the allergen specific commercial ELISA kits using the same immunoreagents and quantitative information on individual food allergen levels. Moreover, the flexibility of the methodology makes it readily translate to the detection of other food-allergens.

  14. Simultaneous Detection of Displacement, Rotation Angle, and Contact Pressure Using Sandpaper Molded Elastomer Based Triple Electrode Sensor.

    Science.gov (United States)

    Choi, Eunsuk; Sul, Onejae; Lee, Seung-Beck

    2017-09-06

    In this article, we report on a flexible sensor based on a sandpaper molded elastomer that simultaneously detects planar displacement, rotation angle, and vertical contact pressure. When displacement, rotation, and contact pressure are applied, the contact area between the translating top elastomer electrode and the stationary three bottom electrodes change characteristically depending on the movement, making it possible to distinguish between them. The sandpaper molded undulating surface of the elastomer reduces friction at the contact allowing the sensor not to affect the movement during measurement. The sensor showed a 0.25 mm −1 displacement sensitivity with a ±33 μm accuracy, a 0.027 degree −1 of rotation sensitivity with ~0.95 degree accuracy, and a 4.96 kP −1 of pressure sensitivity. For possible application to joint movement detection, we demonstrated that our sensor effectively detected the up-and-down motion of a human forefinger and the bending and straightening motion of a human arm.

  15. High-yield benzocyclobutene(BCB) based neural implants for simultaneous intra- and extracortical recording in rats.

    Science.gov (United States)

    Zhu, Haixin; He, Jiping; Kim, Bruce

    2004-01-01

    A unique structure for chronically implantable cortical electrodes based on benzocyclobutene (BCB) biopolymer was designed to perform intracortical and extracortical neural recording simultaneously in basic neuroscience research using animal models. It was fabricated on silicon wafer using standard planar CMOS surface microfabrication technique. Dry-etchable BCB was used to insulate the electrode and provide flexibility for micro-motion compliance between brain tissue and skull. This electrode is also designed to ease the handling and implantation during the surgery and to integrate buffer circuits to improve the signal-to-noise ratio. The reliable fabrication process was developed to improve the electrode yield and performance. A 15 microm thick tungsten layer was sandwiched in the electrode tip to improve the stiffness for easy insertion during the surgery. The fabricated electrodes have two intra-cortical recording sites (20 x 20 microm) in the tip penetrating into the cortex and two epidural recording sites (80 x 80 microm) on each side wing, providing a 6 channel system. One via (40 x 40 microm) was also incorporated in the tip to balance the tip and provide the bio-seeding to improve the implants and neural tissue interaction. The acute surgical testing suggests that this electrode structure can penetrate the pia into the cortical tissue without damaging the electrode.

  16. Electrochemical sensor based on graphene and mesoporous TiO2 for the simultaneous determination of trace colourants in food.

    Science.gov (United States)

    Gan, Tian; Sun, Junyong; Meng, Wen; Song, Li; Zhang, Yuxia

    2013-12-15

    Currently, synthetic colourants draw much attention as food additives. This paper investigated the simultaneous electrocatalytic oxidation of sunset yellow and tartrazine, two yellow colourants commonly present in food together, with a novel voltammetric sensor based on graphene and mesoporous TiO2 modified carbon paste electrode. Due to the high accumulation effect and great catalytic capability of graphene and mesoporous TiO2, the developed sensor exhibited well-defined and separate square wave voltammetric peaks (i.e., 272 mV) for sunset yellow tartrazine. The peak currents of sunset yellow and tartrazine increased linearly with their concentration in the ranges of 0.02-2.05 μM and 0.02-1.18 μM, respectively. And the detection limit was 6.0 and 8.0 nM for sunset yellow and tartrazine, respectively. This new sensor was applied to determine sunset yellow and tartrazine in several food sample extracts. Results suggested that the proposed sensor was sensitive, rapid and reliable. Copyright © 2013 Elsevier Ltd. All rights reserved.

  17. Scientific bases of biomass processing into basic component of aviation fuel

    Science.gov (United States)

    Kachalov, V. V.; Lavrenov, V. A.; Lishchiner, I. I.; Malova, O. V.; Tarasov, A. L.; Zaichenko, V. M.

    2016-11-01

    A combination of feedstock pyrolysis and the cracking of the volatile pyrolysis products on the charcoal at 1000 °C allows to obtain a tarless synthesis gas which contains 90 vol% or more of carbon monoxide and hydrogen in approximately equal proportions. Basic component of aviation fuel was synthesized in a two-stage process from gas obtained by pyrolytic processing of biomass. Methanol and dimethyl ether can be efficiently produced in a two-layer loading of methanolic catalyst and γ-Al2O3. The total conversion of CO per pass was 38.2% using for the synthesis of oxygenates a synthesis gas with adverse ratio of H2/CO = 0.96. Conversion of CO to CH3OH was 15.3% and the conversion of CO to dimethyl ether was 20.9%. A high yield of basic component per oxygenates mass (44.6%) was obtained during conversion. The high selectivity of the synthesis process for liquid hydrocarbons was observed. An optimal recipe of aviation fuel B-92 based on a synthesized basic component was developed. The prototype of aviation fuel meets the requirements for B-92 when straight fractions of 50-100 °C (up to 35 wt%), isooctane (up to 10 wt%) and ethyl fluid (2.0 g/kg calculated as tetraethyl lead) is added to the basic component.

  18. Relevance between SV and components based on water quality inspection by gas plumes

    Science.gov (United States)

    Nakanishi, A.; Aoyama, C.; Fukuoka, H.; Tajima, H.; Kumagai, H.; Takahashi, A.

    2017-12-01

    Gas and hydrate seeping from the seafloor into ocean water can be monitored on board, as images on echogram (acoustic equipment display inboard) by utilizing acoustic measurement equipment such as multi-beam sonars. Colors and shades of these images displayed on the monitor vary depending on the acoustic impedance. Backscattering strength (hereinafter referred as SV) depends on the type and density of plume components. Therefore, plume components should not be determined only by examining volume scattering density. By standardizing the relevance between gas plume SV and the components, types of plume components can be presumed just by calculating plume SV based on multi-beam data.Data from the following explorations will be utilized to perform the analysis of metal sensor, CTD measurement, and sampling. July, 2017 KAIYO-MARU2 (KAIYO ENGINEERING CO., LTD) @ Sea of Japan July, 2017 SIHNYO MARU (Tokyo University of Marine Science and Technology) @ Sea of Japan. And Chemical data obtained through YK16-07 cruise is also to be discussed.

  19. Blood component therapy in anesthesia and intensive care: Adoption of evidence based approaches

    Directory of Open Access Journals (Sweden)

    Sukhminder Jit Singh Bajwa

    2014-01-01

    Full Text Available Transfusion of blood and its components has undergone technological advancement, and its use is increasing both perioperatively as well as in the Intensive Care Unit. The separation of blood into its various components has made it very economical as blood donated from a single donor can be utilized for many recipients at the same time. However, the transfusion of blood and its components do carry the inherent risk of various transfusion reactions as well as transmission of infections. The indications for transfusion should be strictly adhered to for preventing nonjudicious use. The health care persons involved in transfusion should be well aware of implications of the mismatched transfusion and should be able to provide treatment if such mishaps do occur. A health care professional should carefully weigh the benefits of blood transfusion against the risks involved before subjecting the patients to the transfusion. This manuscript aims to comprehensively review the current evidence based approaches in blood and component transfusion which are being followed in anesthesiology and intensive care practice.

  20. Facilitating in vivo tumor localization by principal component analysis based on dynamic fluorescence molecular imaging

    Science.gov (United States)

    Gao, Yang; Chen, Maomao; Wu, Junyu; Zhou, Yuan; Cai, Chuangjian; Wang, Daliang; Luo, Jianwen

    2017-09-01

    Fluorescence molecular imaging has been used to target tumors in mice with xenograft tumors. However, tumor imaging is largely distorted by the aggregation of fluorescent probes in the liver. A principal component analysis (PCA)-based strategy was applied on the in vivo dynamic fluorescence imaging results of three mice with xenograft tumors to facilitate tumor imaging, with the help of a tumor-specific fluorescent probe. Tumor-relevant features were extracted from the original images by PCA and represented by the principal component (PC) maps. The second principal component (PC2) map represented the tumor-related features, and the first principal component (PC1) map retained the original pharmacokinetic profiles, especially of the liver. The distribution patterns of the PC2 map of the tumor-bearing mice were in good agreement with the actual tumor location. The tumor-to-liver ratio and contrast-to-noise ratio were significantly higher on the PC2 map than on the original images, thus distinguishing the tumor from its nearby fluorescence noise of liver. The results suggest that the PC2 map could serve as a bioimaging marker to facilitate in vivo tumor localization, and dynamic fluorescence molecular imaging with PCA could be a valuable tool for future studies of in vivo tumor metabolism and progression.

  1. A component-based system for agricultural drought monitoring by remote sensing.

    Science.gov (United States)

    Dong, Heng; Li, Jun; Yuan, Yanbin; You, Lin; Chen, Chao

    2017-01-01

    In recent decades, various kinds of remote sensing-based drought indexes have been proposed and widely used in the field of drought monitoring. However, the drought-related software and platform development lag behind the theoretical research. The current drought monitoring systems focus mainly on information management and publishing, and cannot implement professional drought monitoring or parameter inversion modelling, especially the models based on multi-dimensional feature space. In view of the above problems, this paper aims at fixing this gap with a component-based system named RSDMS to facilitate the application of drought monitoring by remote sensing. The system is designed and developed based on Component Object Model (COM) to ensure the flexibility and extendibility of modules. RSDMS realizes general image-related functions such as data management, image display, spatial reference management, image processing and analysis, and further provides drought monitoring and evaluation functions based on internal and external models. Finally, China's Ningxia region is selected as the study area to validate the performance of RSDMS. The experimental results show that RSDMS provide an efficient and scalable support to agricultural drought monitoring.

  2. A component-based system for agricultural drought monitoring by remote sensing.

    Directory of Open Access Journals (Sweden)

    Heng Dong

    Full Text Available In recent decades, various kinds of remote sensing-based drought indexes have been proposed and widely used in the field of drought monitoring. However, the drought-related software and platform development lag behind the theoretical research. The current drought monitoring systems focus mainly on information management and publishing, and cannot implement professional drought monitoring or parameter inversion modelling, especially the models based on multi-dimensional feature space. In view of the above problems, this paper aims at fixing this gap with a component-based system named RSDMS to facilitate the application of drought monitoring by remote sensing. The system is designed and developed based on Component Object Model (COM to ensure the flexibility and extendibility of modules. RSDMS realizes general image-related functions such as data management, image display, spatial reference management, image processing and analysis, and further provides drought monitoring and evaluation functions based on internal and external models. Finally, China's Ningxia region is selected as the study area to validate the performance of RSDMS. The experimental results show that RSDMS provide an efficient and scalable support to agricultural drought monitoring.

  3. Simultaneous retrieval of aerosol and surface optical properties from combined airborne- and ground-based direct and diffuse radiometric measurements

    Directory of Open Access Journals (Sweden)

    C. K. Gatebe

    2010-03-01

    Full Text Available This paper presents a new method for simultaneously retrieving aerosol and surface reflectance properties from combined airborne and ground-based direct and diffuse radiometric measurements. The method is based on the standard Aerosol Robotic Network (AERONET method for retrieving aerosol size distribution, complex index of refraction, and single scattering albedo, but modified to retrieve aerosol properties in two layers, below and above the aircraft, and parameters on surface optical properties from combined datasets (Cloud Absorption Radiometer (CAR and AERONET data. A key advantage of this method is the inversion of all available spectral and angular data at the same time, while accounting for the influence of noise in the inversion procedure using statistical optimization. The wide spectral (0.34–2.30 μm and angular range (180° of the CAR instrument, combined with observations from an AERONET sunphotometer, provide sufficient measurement constraints for characterizing aerosol and surface properties with minimal assumptions. The robustness of the method was tested on observations made during four different field campaigns: (a the Southern African Regional Science Initiative 2000 over Mongu, Zambia, (b the Intercontinental Transport Experiment-Phase B over Mexico City, Mexico (c Cloud and Land Surface Interaction Campaign over the Atmospheric Radiation Measurement (ARM Central Facility, Oklahoma, USA, and (d the Arctic Research of the Composition of the Troposphere from Aircraft and Satellites (ARCTAS over Elson Lagoon in Barrow, Alaska, USA. The four areas are dominated by different surface characteristics and aerosol types, and therefore provide good test cases for the new inversion method.

  4. Simultaneous detection of IgG antibodies associated with viral hemorrhagic fever by a multiplexed Luminex-based immunoassay.

    Science.gov (United States)

    Wu, Wei; Zhang, Shuo; Qu, Jing; Zhang, Quanfu; Li, Chuan; Li, Jiandong; Jin, Cong; Liang, Mifang; Li, Dexin

    2014-07-17

    Viral hemorrhagic fevers (VHFs) are worldwide diseases caused by several kinds of viruses. With the emergence of new viruses, advanced diagnostic methods are urgently needed for identification of VHFs. Based on Luminex xMAP technology, a rapid, sensitive, multi-pathogen and high-throughput method which could simultaneously detect hemorrhagic fever viruses (HFVs) specific IgG antibodies was developed. Recombinant antigens of nine HFVs including Hantaan virus (HTNV), Seoul virus (SEOV), Puumala virus (PUUV), Andes virus (ANDV), Sin Nombre virus (SNV), Crimean-Congo hemorrhagic fever virus (CCHFV), Rift Valley fever virus (RVFV), Severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) and dengue virus (DENV) were produced and purified from a prokaryotic expression system and the influence of the coupling amount was investigated. Cross-reactions among antigens and their rabbit immune sera were evaluated. Serum samples collected from 51 laboratory confirmed hemorrhagic fever with renal syndrome (HFRS) patients, 43 confirmed SFTS patients and 88 healthy donors were analyzed. Results showed that recombinant nucleocapsid protein of the five viruses belonging to the genus Hantavirus, had serological cross-reactivity with their corresponding rabbit immune sera, but not apparent with immune sera of other four viruses. Evaluation of this new method with clinical serum samples showed 98.04% diagnostic sensitivity for HFRS, 90.70% for SFTS detection and the specificity was ranging from 66.67% to 100.00%. The multiplexed Luminex-based immunoassay has firstly been established in our study, which provides a potentially reliable diagnostic tool for IgG antibody detection of VHFs. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. A Co-modeling Method Based on Component Features for Mechatronic Devices in Aero-engines

    Science.gov (United States)

    Wang, Bin; Zhao, Haocen; Ye, Zhifeng

    2017-08-01

    Data-fused and user-friendly design of aero-engine accessories is required because of their structural complexity and stringent reliability. This paper gives an overview of a typical aero-engine control system and the development process of key mechatronic devices used. Several essential aspects of modeling and simulation in the process are investigated. Considering the limitations of a single theoretic model, feature-based co-modeling methodology is suggested to satisfy the design requirements and compensate for diversity of component sub-models for these devices. As an example, a stepper motor controlled Fuel Metering Unit (FMU) is modeled in view of the component physical features using two different software tools. An interface is suggested to integrate the single discipline models into the synthesized one. Performance simulation of this device using the co-model and parameter optimization for its key components are discussed. Comparison between delivery testing and the simulation shows that the co-model for the FMU has a high accuracy and the absolute superiority over a single model. Together with its compatible interface with the engine mathematical model, the feature-based co-modeling methodology is proven to be an effective technical measure in the development process of the device.

  6. Vibration energy harvesting based on integrated piezoelectric components operating in different modes.

    Science.gov (United States)

    Hu, Junhui; Jong, Januar; Zhao, Chunsheng

    2010-01-01

    To increase the vibration energy-harvesting capability of the piezoelectric generator based on a cantilever beam, we have proposed a piezoelectric generator that not only uses the strain change of piezoelectric components bonded on a cantilever beam, but also employs the weights at the tip of the cantilever beam to hit piezoelectric components located on the 2 sides of weights. A prototype of the piezoelectric generator has been fabricated and its characteristics have been measured and analyzed. The experimental results show that the piezoelectric components operating in the hit mode can substantially enhance the energy harvesting of the piezoelectric generator on a cantilever beam. Two methods are used and compared in the management of rectified output voltages from different groups of piezoelectric components. In one of them, the DC voltages from rectifiers are connected in series, and then the total DC voltage is applied to a capacitor. In another connection, the DC voltage from each group is applied to different capacitors. It is found that 22.3% of the harvested energy is wasted due to the series connection. The total output electric energy of our piezoelectric generator at nonresonance could be up to 43 nJ for one vibration excitation applied by spring, with initial vibration amplitude (0-p) of 18 mm and frequency of 18.5 Hz, when the rectified voltages from different groups of piezoelectric components are connected to their individual capacitors. In addition, the motion and impact of the weights at the tip of the cantilever beam are theoretically analyzed, which well explains the experimental phenomena and suggests the measures to improve the generator.

  7. A block matching based approach with multiple simultaneous templates for the real-time 2D ultrasound tracking of liver vessels.

    Science.gov (United States)

    Shepard, Andrew J; Wang, Bo; Foo, Thomas K F; Bednarz, Bryan P

    2017-11-01

    The implementation of motion management techniques in radiation therapy can aid in mitigating uncertainties and reducing margins. For motion management to be effective, it is necessary to track key structures both accurately and at a real-time speed. Therefore, the focus of this work was to develop a 2D algorithm for the real-time tracking of ultrasound features to aid in radiation therapy motion management. The developed algorithm utilized a similarity measure-based block matching algorithm incorporating training methods and multiple simultaneous templates. The algorithm is broken down into three primary components, all of which use normalized cross-correlation (NCC) as a similarity metric. First, a global feature shift to account for gross displacements from the previous frame is determined using large block sizes which encompass the entirety of the feature. Second, the most similar reference frame is chosen from a series of training images that are accumulated during the first K frames of tracking to aid in contour consistency and provide a starting point for the localized template initialization. Finally, localized block matching is performed through the simultaneous use of both a training frame and the previous frame. The localized block matching utilizes a series of templates positioned at the boundary points of the training and previous contours. The weighted final boundary points from both the previous and the training frame are ultimately combined and used to determine an affine transformation from the previous frame to the current frame. A mean tracking error of 0.72 ± 1.25 mm was observed for 85 point-landmarks across 39 ultrasound sequences relative to manual ground truth annotations. The image processing speed per landmark with the GPU implementation was between 41 and 165 frames per second (fps) during the training set accumulation, and between 73 and 234 fps after training set accumulation. Relative to a comparable multithreaded CPU approach using

  8. Photonic Beamformer Model Based on Analog Fiber-Optic Links’ Components

    Science.gov (United States)

    Volkov, V. A.; Gordeev, D. A.; Ivanov, S. I.; Lavrov, A. P.; Saenko, I. I.

    2016-08-01

    The model of photonic beamformer for wideband microwave phased array antenna is investigated. The main features of the photonic beamformer model based on true-time-delay technique, DWDM technology and fiber chromatic dispersion are briefly analyzed. The performance characteristics of the key components of photonic beamformer for phased array antenna in the receive mode are examined. The beamformer model composed of the components available on the market of fiber-optic analog communication links is designed and tentatively investigated. Experimental demonstration of the designed model beamforming features includes actual measurement of 5-element microwave linear array antenna far-field patterns in 6-16 GHz frequency range for antenna pattern steering up to 40°. The results of experimental testing show good accordance with the calculation estimates.

  9. Analysis of Active Components in Salvia Miltiorrhiza Injection Based on Vascular Endothelial Cell Protection

    Directory of Open Access Journals (Sweden)

    Shen Jie

    2014-09-01

    Full Text Available Correlation analysis based on chromatograms and pharmacological activities is essential for understanding the effective components in complex herbal medicines. In this report, HPLC and measurement of antioxidant properties were used to describe the active ingredients of Salvia miltiorrhiza injection (SMI. HPLC results showed that tanshinol, protocatechuic aldehyde, rosmarinic acid, salvianolic acid B, protocatechuic acid and their metabolites in rat serum may contribute to the efficacy of SMI. Assessment of antioxidant properties indicated that differences in the composition of serum powder of SMI caused differences in vascular endothelial cell protection. When bivariate correlation was carried out it was found that salvianolic acid B, tanshinol and protocatechuic aldehyde were active components of SMI because they were correlated to antioxidant properties.

  10. Mapping of Core Components Based e-Business Standards into Ontology

    Science.gov (United States)

    Magdalenić, Ivan; Vrdoljak, Boris; Schatten, Markus

    A mapping of Core Components specification based e-business standards to an ontology is presented. The Web Ontology Language (OWL) is used for ontology development. In order to preserve the existing hierarchy of the standards, an emphasis is put on the mapping of Core Components elements to specific constructs in OWL. The main purpose of developing an e-business standards' ontology is to create a foundation for an automated mapping system that would be able to convert concepts from various standards in an independent fashion. The practical applicability and verification of the presented mappings is tested on the mapping of Universal Business Language version 2.0 and Cross Industry Invoice version 2.0 to OWL.

  11. Conceptual design of a fission-based integrated test facility for fusion reactor components

    International Nuclear Information System (INIS)

    Watts, K.D.; Deis, G.A.; Hsu, P.Y.S.; Longhurst, G.R.; Masson, L.S.; Miller, L.G.

    1982-01-01

    The testing of fusion materials and components in fission reactors will become increasingly important because of lack of fusion engineering test devices in the immediate future and the increasing long-term demand for fusion testing when a fusion reactor test station becomes available. This paper presents the conceptual design of a fission-based Integrated Test Facility (ITF) developed by EG and G Idaho. This facility can accommodate entire first wall/blanket (FW/B) test modules such as those proposed for INTOR and can also accommodate smaller cylindrical modules similar to those designed by Oak Ridge National laboratory (ORNL) and Westinghouse. In addition, the facility can be used to test bulk breeder blanket materials, materials for tritium permeation, and components for performance in a nuclear environment. The ITF provides a cyclic neutron/gamma flux as well as the numerous module and experiment support functions required for truly integrated tests

  12. Fluvial facies reservoir productivity prediction method based on principal component analysis and artificial neural network

    Directory of Open Access Journals (Sweden)

    Pengyu Gao

    2016-03-01

    Full Text Available It is difficult to forecast the well productivity because of the complexity of vertical and horizontal developments in fluvial facies reservoir. This paper proposes a method based on Principal Component Analysis and Artificial Neural Network to predict well productivity of fluvial facies reservoir. The method summarizes the statistical reservoir factors and engineering factors that affect the well productivity, extracts information by applying the principal component analysis method and approximates arbitrary functions of the neural network to realize an accurate and efficient prediction on the fluvial facies reservoir well productivity. This method provides an effective way for forecasting the productivity of fluvial facies reservoir which is affected by multi-factors and complex mechanism. The study result shows that this method is a practical, effective, accurate and indirect productivity forecast method and is suitable for field application.

  13. Soft Sensor of Vehicle State Estimation Based on the Kernel Principal Component and Improved Neural Network

    Directory of Open Access Journals (Sweden)

    Haorui Liu

    2016-01-01

    Full Text Available In the car control systems, it is hard to measure some key vehicle states directly and accurately when running on the road and the cost of the measurement is high as well. To address these problems, a vehicle state estimation method based on the kernel principal component analysis and the improved Elman neural network is proposed. Combining with nonlinear vehicle model of three degrees of freedom (3 DOF, longitudinal, lateral, and yaw motion, this paper applies the method to the soft sensor of the vehicle states. The simulation results of the double lane change tested by Matlab/SIMULINK cosimulation prove the KPCA-IENN algorithm (kernel principal component algorithm and improved Elman neural network to be quick and precise when tracking the vehicle states within the nonlinear area. This algorithm method can meet the software performance requirements of the vehicle states estimation in precision, tracking speed, noise suppression, and other aspects.

  14. Study of ferromagnetic component base material on nuclear power plant testing

    International Nuclear Information System (INIS)

    Soedardjo; Histori; Triyadi, Ari

    1998-01-01

    Ferromagnetic component base material testing on Nuclear Power Plant (NPP) has been studied. NPP component was chosen is A533 grade B2 steel, which is commonly used for pressure vessels in light-water reactor. The testing development technology we performed from the acoustic emission measurement and magnetic field measurement combination and namely Barkhausen noise measurement technique. The non destructive Test provides to residual stress and characteristic microstructure measurement. The metallurgical effect and magnetomechanical acoustic emission parameters will be tried to study the Fe-Ni content. The result of study was recrystallization of dislocated grains proceeds at 600 o C and tempering at 650 o C produced annealed ferrite plus carbide structure

  15. Principal components analysis of an evaluation of the hemiplegic subject based on the Bobath approach.

    Science.gov (United States)

    Corriveau, H; Arsenault, A B; Dutil, E; Lepage, Y

    1992-01-01

    An evaluation based on the Bobath approach to treatment has previously been developed and partially validated. The purpose of the present study was to verify the content validity of this evaluation with the use of a statistical approach known as principal components analysis. Thirty-eight hemiplegic subjects participated in the study. Analysis of the scores on each of six parameters (sensorium, active movements, muscle tone, reflex activity, postural reactions, and pain) was evaluated on three occasions across a 2-month period. Each time this produced three factors that contained 70% of the variation in the data set. The first component mainly reflected variations in mobility, the second mainly variations in muscle tone, and the third mainly variations in sensorium and pain. The results of such exploratory analysis highlight the fact that some of the parameters are not only important but also interrelated. These results seem to partially support the conceptual framework substantiating the Bobath approach to treatment.

  16. Layer-component-based communication stack framework for wireless residential control systems

    DEFF Research Database (Denmark)

    Torbensen, Rune; Hjorth, Theis

    2010-01-01

    This paper describes methods to lower the entry barrier for creating products that interoperate in the emerging heterogeneous residential control network domain. For designing reconfigurable, layer-component-based communication stacks, a flexible framework is proposed that supports several types ...... shown how the framework facilitates fast prototyping and makes developing secure wireless control systems less complex....... of nodes such as bridges, controllers, sensor/actuators - as well as secure communication between them. A special messaging system facilitates inter-component communication, and a Virtual Port Service protocol enables resource addressing. The end-devices in the heterogeneous network are made accessible...... on a common IP infrastructure, regardless of individual wireless technology. Legacy home automation devices are also supported. A prototype has been implemented on multiple resource-constrained hardware platforms, to demonstrate that the solution is both feasible for low-cost devices and portable. It has been...

  17. Layer-component-based communication stack framework for wireless residential control systems

    DEFF Research Database (Denmark)

    Torbensen, R.; Hjorth, Theis S.

    2011-01-01

    This paper describes methods to lower the entry barrier for creating products that interoperate in the emerging heterogeneous residential control network domain. For designing reconfigurable, layer-component-based communication stacks, a flexible framework is proposed that supports several types ...... shown how the framework facilitates fast prototyping and makes developing secure wireless control systems less complex....... of nodes such as bridges, controllers, sensor/actuators – as well as secure communication between them. A special messaging system facilitates inter-component communication, and a Virtual Port Service protocol enables resource addressing. The end-devices in the heterogeneous network are made accessible...... on a common IP infrastructure, regardless of individual wireless technology. Legacy home automation devices are also supported. A prototype has been implemented on multiple resource-constrained hardware platforms, to demonstrate that the solution is both feasible for low-cost devices and portable. It has been...

  18. Simultaneous alcohol and cannabis expectancies predict simultaneous use

    Directory of Open Access Journals (Sweden)

    Earleywine Mitch

    2006-10-01

    Full Text Available Abstract Background Simultaneous use of alcohol and cannabis predicts increased negative consequences for users beyond individual or even concurrent use of the two drugs. Given the widespread use of the drugs and common simultaneous consumption, problems unique to simultaneous use may bear important implications for many substance users. Cognitive expectancies offer a template for future drug use behavior based on previous drug experiences, accurately predicting future use and problems. Studies reveal similar mechanisms underlying both alcohol and cannabis expectancies, but little research examines simultaneous expectancies for alcohol and cannabis use. Whereas research has demonstrated unique outcomes associated with simultaneous alcohol and cannabis use, this study hypothesized that unique cognitive expectancies may underlie simultaneous alcohol and cannabis use. Results: This study examined a sample of 2600 (66% male; 34% female Internet survey respondents solicited through advertisements with online cannabis-related organizations. The study employed known measures of drug use and expectancies, as well as a new measure of simultaneous drug use expectancies. Expectancies for simultaneous use of alcohol and cannabis predicted simultaneous use over and above expectancies for each drug individually. Discussion Simultaneous expectancies may provide meaningful information not available with individual drug expectancies. These findings bear potential implications on the assessment and treatment of substance abuse problems, as well as researcher conceptualizations of drug expectancies. Policies directing the treatment of substance abuse and its funding ought to give unique consideration to simultaneous drug use and its cognitive underlying factors.

  19. Simultaneous all-optical demultiplexing and regeneration based on self-phase and cross-phase modulation in a dispersion shifted fiber

    DEFF Research Database (Denmark)

    Yu, Jianjun; Jeppesen, Palle

    2001-01-01

    Simultaneous demultiplexing and regeneration of 40-Gb/s optical time division multiplexed (OTDM) signal based on self-phase and cross-phase modulation in a dispersion shifted fiber is numerically and experimentally investigated. The optimal walkoff time between the control pulse and OTDM signal...

  20. Luminex-based triplex immunoassay for the simultaneous detection of soy, pea, and soluble wheat proteins in milk powder.

    Science.gov (United States)

    Haasnoot, Willem; du Pré, Jolanda G

    2007-05-16

    An automated fluorescent microsphere-based flow cytometric triplex immunoassay, using the Luminex 100 flow analyzer with MultiAnalyte Profiling (xMAP) technology, was developed for the simultaneous detection of proteins from three vegetable sources as potential fraudulent adulterants in milk powder. In the final triplex inhibition immunoassay, soluble wheat proteins (SWP) and proteins from soy and pea were coupled to three different microsphere sets. A mixture of these microsphere sets was transferred to a microtiter plate well together with the sample and a mixture of three affinity-purified polyclonal antibodies raised against the proteins and labeled with a fluorophore (Alexa 532). After incubation for 1.5 h at room temperature in the dark, the fluorescence intensities on the microspheres were directly measured (no wash procedure) in the Luminex during 10 s per well (100 microspheres per set). The sensitivities of the three assays for plant protein extracts were determined as 0.5-0.6 microg/mL at 50% inhibition. For the detection of the vegetable proteins in milk powder, the samples were dissolved in buffer (0.1 g in 10 mL) and further diluted (20 times) to create a 50% inhibition at approximately 0.5% of the vegetable proteins in the total protein content of milk powder. With the help of calibration standards, prepared under conditions comparable to those for sample materials, the triplex immunoassay proved to be quantitative above 0.1%, although concentrations in high-heated milk powders were underestimated. Due to the xMAP technology, in which 100 different microsphere sets can be distinguished, this triplex immunoassay can easily be extended to detect other possible adulterants.

  1. A simple and fast method based on mixed hemimicelles coated magnetite nanoparticles for simultaneous extraction of acidic and basic pollutants.

    Science.gov (United States)

    Asgharinezhad, Ali Akbar; Ebrahimzadeh, Homeira

    2016-01-01

    One of the considerable and disputable areas in analytical chemistry is a single-step simultaneous extraction of acidic and basic pollutants. In this research, a simple and fast coextraction of acidic and basic pollutants (with different polarities) with the aid of magnetic dispersive micro-solid phase extraction based on mixed hemimicelles assembly was introduced for the first time. Cetyltrimethylammonium bromide (CTAB)-coated Fe3O4 nanoparticles as an efficient sorbent was successfully applied to adsorb 4-nitrophenol and 4-chlorophenol as two acidic and chlorinated aromatic amines as basic model compounds. Using a central composite design methodology combined with desirability function approach, the optimal experimental conditions were evaluated. The opted conditions were pH = 10; concentration of CTAB = 0.86 mmol L(-1); sorbent amount = 55.5 mg; sorption time = 11.0 min; no salt addition to the sample, type, and volume of the eluent = 120 μL methanol containing 5% acetic acid and 0.01 mol L(-1) HCl; and elution time = 1.0 min. Under the optimum conditions, detection limits and linear dynamic ranges were achieved in the range of 0.05-0.1 and 0.25-500 μg L(-1), respectively. The percent of extraction recoveries and relative standard deviations (n = 5) were in the range of 71.4-98.0 and 4.5-6.5, respectively. The performance of the optimized method was certified by coextraction of other acidic and basic compounds. Ultimately, the applicability of the method was successfully confirmed by the extraction and determination of the target analytes in various water samples, and satisfactory results were obtained.

  2. A 13.56-mbps pulse delay modulation based transceiver for simultaneous near-field data and power transmission.

    Science.gov (United States)

    Kiani, Mehdi; Ghovanloo, Maysam

    2015-02-01

    A fully-integrated near-field wireless transceiver has been presented for simultaneous data and power transmission across inductive links, which operates based on pulse delay modulation (PDM) technique. PDM is a low-power carrier-less modulation scheme that offers wide bandwidth along with robustness against strong power carrier interference, which makes it suitable for implantable neuroprosthetic devices, such as retinal implants. To transmit each bit, a pattern of narrow pulses are generated at the same frequency of the power carrier across the transmitter (Tx) data coil with specific time delays to initiate decaying ringing across the tuned receiver (Rx) data coil. This ringing shifts the zero-crossing times of the undesired power carrier interference on the Rx data coil, resulting in a phase shift between the signals across Rx power and data coils, from which the data bit stream can be recovered. A PDM transceiver prototype was fabricated in a 0.35- μm standard CMOS process, occupying 1.6 mm(2). The transceiver achieved a measured 13.56 Mbps data rate with a raw bit error rate (BER) of 4.3×10(-7) at 10 mm distance between figure-8 data coils, despite a signal-to-interference ratio (SIR) of -18.5 dB across the Rx data coil. At the same time, a class-D power amplifier, operating at 13.56 MHz, delivered 42 mW of regulated power across a separate pair of high-Q power coils, aligned with the data coils. The PDM data Tx and Rx power consumptions were 960 pJ/bit and 162 pJ/bit, respectively, at 1.8 V supply voltage.

  3. Atmospheric Correction Based on Principal Component Analysis in Highly Turbid Waters of the Río de la Plata Estuary

    Science.gov (United States)

    Gossn, J. I.; Frouin, R.; Dogliotti, A. I.; Grings, F. M.

    2016-02-01

    Monitoring of water quality by satellite ocean color data requires accurate atmospheric correction. The treatment of the atmospheric signal becomes more complicated in turbid coastal regions, where the usual black pixel assumption in the Near Infra-Red (NIR) correction bands is oftenly invalid due to high backscattering from suspended substances present in the water. One of the usually proposed solutions is to assign correction bands further apart in the spectrum: the Short-Wave Infra-Red (SWIR) bands, where the black pixel assumption still holds in turbid waters due to higher water absorption. But in exceptionally turbid regions, such as in the Río de la Plata estuary, where suspended particulate matter concentration can surpass 400 mg/L, the marine signal at 1240 nm may exceed 0.2%, that is, not black for the purpose of atmospheric correction. Moreover, as the spectral distances between the correction bands and the NIR region increases, the correlation between the atmospheric signals of the former with the latter ones usually worsens, threatening the accuracy of the atmospheric correction. In this work, an atmospheric correction scheme based on Principal Component Analysis of the TOA signal and a simple expression for the transmission coefficient was proposed to estimate water reflectance in the NIR region using four different sets of SWIR correction bands present in MODIS and in the Argentinian-Brazilian future sensor SABIA-Mar. Two factors changed between the four sets: the amount of bands used (2 or 3 bands) and the spectral distance to the NIR, which regulates simultaneously the degree of correlation and the validity of the black pixel assumption. The atmospheric correction performances were evaluated from a set of simulations of TOA signals using the CNES-SOS radiative transfer code and in situ data available for the Río de la Plata region. All four schemes present better performances when low observation and solar zenith angles (i.e. at low air masses

  4. Study on fatigue life evaluation of structural component based on crack growth criterion

    International Nuclear Information System (INIS)

    Shibata, Katsuyuki

    1984-07-01

    As one of the practical application of fracture mechanics, fatigue life evaluation method based on crack growth criterion has been diffusing in various field of technology in order to determine the rational and reliable life of structural components. The fatigue life by this method is evaluated based on the fatigue crack growth analysis from defects, while many problems, such as the influence of residual stress on the crack growth behavior, the effect of overloading, and evaluation method for multiple surface cracks, are not sufficiently solved yet. In this paper, the above problems are treated, and based on some exprimental data some simple mehtods for fatigue life evaluation are proposed regarding the above problems. Verification of the proposed methods are shown in the paper by comparing with some experimental results, and the applicability of the proposed method is also examined by the fatigue test of pipes with cracks in the inner surface. (author)

  5. A Biometric Face Recognition System Using an Algorithm Based on the Principal Component Analysis Technique

    Directory of Open Access Journals (Sweden)

    Gheorghe Gîlcă

    2015-06-01

    Full Text Available This article deals with a recognition system using an algorithm based on the Principal Component Analysis (PCA technique. The recognition system consists only of a PC and an integrated video camera. The algorithm is developed in MATLAB language and calculates the eigenfaces considered as features of the face. The PCA technique is based on the matching between the facial test image and the training prototype vectors. The mathcing score between the facial test image and the training prototype vectors is calculated between their coefficient vectors. If the matching is high, we have the best recognition. The results of the algorithm based on the PCA technique are very good, even if the person looks from one side at the video camera.

  6. Resource Properties Expression and Runtime assurance for embedded programs, using Qinna, a component-based software architecture

    OpenAIRE

    Gonnord , Laure; Babau , Jean-Philippe

    2008-01-01

    Designing embedded communicating systems such as PDAs, mobile phones, is getting more and more complex as the hardware performance grows. The component paradigm appears as promising mainly due to the reusability and flexibility of code, but new problems appear such as security, safety and quality of service managements, which have not been integrated in the component-based designs. In this context, a component-based software architecture, Qinna, has been designed to manage quality of service ...

  7. Power Transformer Differential Protection Based on Neural Network Principal Component Analysis, Harmonic Restraint and Park's Plots

    Directory of Open Access Journals (Sweden)

    Manoj Tripathy

    2012-01-01

    Full Text Available This paper describes a new approach for power transformer differential protection which is based on the wave-shape recognition technique. An algorithm based on neural network principal component analysis (NNPCA with back-propagation learning is proposed for digital differential protection of power transformer. The principal component analysis is used to preprocess the data from power system in order to eliminate redundant information and enhance hidden pattern of differential current to discriminate between internal faults from inrush and overexcitation conditions. This algorithm has been developed by considering optimal number of neurons in hidden layer and optimal number of neurons at output layer. The proposed algorithm makes use of ratio of voltage to frequency and amplitude of differential current for transformer operating condition detection. This paper presents a comparative study of power transformer differential protection algorithms based on harmonic restraint method, NNPCA, feed forward back propagation neural network (FFBPNN, space vector analysis of the differential signal, and their time characteristic shapes in Park’s plane. The algorithms are compared as to their speed of response, computational burden, and the capability to distinguish between a magnetizing inrush and power transformer internal fault. The mathematical basis for each algorithm is briefly described. All the algorithms are evaluated using simulation performed with PSCAD/EMTDC and MATLAB.

  8. Robust and Effective Component-based Banknote Recognition by SURF Features.

    Science.gov (United States)

    Hasanuzzaman, Faiz M; Yang, Xiaodong; Tian, YingLi

    2011-01-01

    Camera-based computer vision technology is able to assist visually impaired people to automatically recognize banknotes. A good banknote recognition algorithm for blind or visually impaired people should have the following features: 1) 100% accuracy, and 2) robustness to various conditions in different environments and occlusions. Most existing algorithms of banknote recognition are limited to work for restricted conditions. In this paper we propose a component-based framework for banknote recognition by using Speeded Up Robust Features (SURF). The component-based framework is effective in collecting more class-specific information and robust in dealing with partial occlusion and viewpoint changes. Furthermore, the evaluation of SURF demonstrates its effectiveness in handling background noise, image rotation, scale, and illumination changes. To authenticate the robustness and generalizability of the proposed approach, we have collected a large dataset of banknotes from a variety of conditions including occlusion, cluttered background, rotation, and changes of illumination, scaling, and viewpoints. The proposed algorithm achieves 100% recognition rate on our challenging dataset.

  9. A configurable component-based software system for magnetic field measurements

    Energy Technology Data Exchange (ETDEWEB)

    Nogiec, J.M.; DiMarco, J.; Kotelnikov, S.; Trombly-Freytag, K.; Walbridge, D.; Tartaglia, M.; /Fermilab

    2005-09-01

    A new software system to test accelerator magnets has been developed at Fermilab. The magnetic measurement technique involved employs a single stretched wire to measure alignment parameters and magnetic field strength. The software for the system is built on top of a flexible component-based framework, which allows for easy reconfiguration and runtime modification. Various user interface, data acquisition, analysis, and data persistence components can be configured to form different measurement systems that are tailored to specific requirements (e.g., involving magnet type or test stand). The system can also be configured with various measurement sequences or tests, each of them controlled by a dedicated script. It is capable of working interactively as well as executing a preselected sequence of tests. Each test can be parameterized to fit the specific magnet type or test stand requirements. The system has been designed with portability in mind and is capable of working on various platforms, such as Linux, Solaris, and Windows. It can be configured to use a local data acquisition subsystem or a remote data acquisition computer, such as a VME processor running VxWorks. All hardware-oriented components have been developed with a simulation option that allows for running and testing measurements in the absence of data acquisition hardware.

  10. Modelling Creativity: Identifying Key Components through a Corpus-Based Approach.

    Science.gov (United States)

    Jordanous, Anna; Keller, Bill

    2016-01-01

    Creativity is a complex, multi-faceted concept encompassing a variety of related aspects, abilities, properties and behaviours. If we wish to study creativity scientifically, then a tractable and well-articulated model of creativity is required. Such a model would be of great value to researchers investigating the nature of creativity and in particular, those concerned with the evaluation of creative practice. This paper describes a unique approach to developing a suitable model of how creative behaviour emerges that is based on the words people use to describe the concept. Using techniques from the field of statistical natural language processing, we identify a collection of fourteen key components of creativity through an analysis of a corpus of academic papers on the topic. Words are identified which appear significantly often in connection with discussions of the concept. Using a measure of lexical similarity to help cluster these words, a number of distinct themes emerge, which collectively contribute to a comprehensive and multi-perspective model of creativity. The components provide an ontology of creativity: a set of building blocks which can be used to model creative practice in a variety of domains. The components have been employed in two case studies to evaluate the creativity of computational systems and have proven useful in articulating achievements of this work and directions for further research.

  11. Crude oil price analysis and forecasting based on variational mode decomposition and independent component analysis

    Science.gov (United States)

    E, Jianwei; Bao, Yanling; Ye, Jimin

    2017-10-01

    As one of the most vital energy resources in the world, crude oil plays a significant role in international economic market. The fluctuation of crude oil price has attracted academic and commercial attention. There exist many methods in forecasting the trend of crude oil price. However, traditional models failed in predicting accurately. Based on this, a hybrid method will be proposed in this paper, which combines variational mode decomposition (VMD), independent component analysis (ICA) and autoregressive integrated moving average (ARIMA), called VMD-ICA-ARIMA. The purpose of this study is to analyze the influence factors of crude oil price and predict the future crude oil price. Major steps can be concluded as follows: Firstly, applying the VMD model on the original signal (crude oil price), the modes function can be decomposed adaptively. Secondly, independent components are separated by the ICA, and how the independent components affect the crude oil price is analyzed. Finally, forecasting the price of crude oil price by the ARIMA model, the forecasting trend demonstrates that crude oil price declines periodically. Comparing with benchmark ARIMA and EEMD-ICA-ARIMA, VMD-ICA-ARIMA can forecast the crude oil price more accurately.

  12. Airborne electromagnetic data levelling using principal component analysis based on flight line difference

    Science.gov (United States)

    Zhang, Qiong; Peng, Cong; Lu, Yiming; Wang, Hao; Zhu, Kaiguang

    2018-04-01

    A novel technique is developed to level airborne geophysical data using principal component analysis based on flight line difference. In the paper, flight line difference is introduced to enhance the features of levelling error for airborne electromagnetic (AEM) data and improve the correlation between pseudo tie lines. Thus we conduct levelling to the flight line difference data instead of to the original AEM data directly. Pseudo tie lines are selected distributively cross profile direction, avoiding the anomalous regions. Since the levelling errors of selective pseudo tie lines show high correlations, principal component analysis is applied to extract the local levelling errors by low-order principal components reconstruction. Furthermore, we can obtain the levelling errors of original AEM data through inverse difference after spatial interpolation. This levelling method does not need to fly tie lines and design the levelling fitting function. The effectiveness of this method is demonstrated by the levelling results of survey data, comparing with the results from tie-line levelling and flight-line correlation levelling.

  13. Ultrasound-Based Characterization of Prostate Cancer Using Joint Independent Component Analysis.

    Science.gov (United States)

    Imani, Farhad; Ramezani, Mahdi; Nouranian, Saman; Gibson, Eli; Khojaste, Amir; Gaed, Mena; Moussa, Madeleine; Gomez, Jose A; Romagnoli, Cesare; Leveridge, Michael; Chang, Silvia; Fenster, Aaron; Siemens, D Robert; Ward, Aaron D; Mousavi, Parvin; Abolmaesumi, Purang

    2015-07-01

    This paper presents the results of a new approach for selection of RF time series features based on joint independent component analysis for in vivo characterization of prostate cancer. We project three sets of RF time series features extracted from the spectrum, fractal dimension, and the wavelet transform of the ultrasound RF data on a space spanned by five joint independent components. Then, we demonstrate that the obtained mixing coefficients from a group of patients can be used to train a classifier, which can be applied to characterize cancerous regions of a test patient. In a leave-one-patient-out cross validation, an area under receiver operating characteristic curve of 0.93 and classification accuracy of 84% are achieved. Ultrasound RF time series can be used to accurately characterize prostate cancer, in vivo without the need for exhaustive search in the feature space. We use joint independent component analysis for systematic fusion of multiple sets of RF time series features, within a machine learning framework, to characterize PCa in an in vivo study.

  14. Component design challenges for the ground-based SP-100 nuclear assembly test

    International Nuclear Information System (INIS)

    Markley, R.A.; Disney, R.K.; Brown, G.B.

    1989-01-01

    The SP-100 ground engineering system (GES) program involves a ground test of the nuclear subsystems to demonstrate their design. The GES nuclear assembly test (NAT) will be performed in a simulated space environment within a vessel maintained at ultrahigh vacuum. The NAT employs a radiation shielding system that is comprised of both prototypical and nonprototypical shield subsystems to attenuate the reactor radiation leakage and also nonprototypical heat transport subsystems to remove the heat generated by the reactor. The reactor is cooled by liquid lithium, which will operate at temperatures prototypical of the flight system. In designing the components for these systems, a number of design challenges were encountered in meeting the operational requirements of the simulated space environment (and where necessary, prototypical requirements) while also accommodating the restrictions of a ground-based test facility with its limited available space. This paper presents a discussion of the design challenges associated with the radiation shield subsystem components and key components of the heat transport systems

  15. Modelling Creativity: Identifying Key Components through a Corpus-Based Approach

    Science.gov (United States)

    2016-01-01

    Creativity is a complex, multi-faceted concept encompassing a variety of related aspects, abilities, properties and behaviours. If we wish to study creativity scientifically, then a tractable and well-articulated model of creativity is required. Such a model would be of great value to researchers investigating the nature of creativity and in particular, those concerned with the evaluation of creative practice. This paper describes a unique approach to developing a suitable model of how creative behaviour emerges that is based on the words people use to describe the concept. Using techniques from the field of statistical natural language processing, we identify a collection of fourteen key components of creativity through an analysis of a corpus of academic papers on the topic. Words are identified which appear significantly often in connection with discussions of the concept. Using a measure of lexical similarity to help cluster these words, a number of distinct themes emerge, which collectively contribute to a comprehensive and multi-perspective model of creativity. The components provide an ontology of creativity: a set of building blocks which can be used to model creative practice in a variety of domains. The components have been employed in two case studies to evaluate the creativity of computational systems and have proven useful in articulating achievements of this work and directions for further research. PMID:27706185

  16. Mechano-optical modulator based on a rotating optical flat applied to simultaneous holographic multiplexing of gratings.

    Science.gov (United States)

    Matrisch, Jan; Altmeyer, Stefan

    2018-01-10

    Simultaneous holographic multiplexing methods are used to store multiple holograms concurrently into one holographic volume. Compared to serial exposure, one advantage is the higher processing speed. Additionally, for parallel exposure the different gratings develop in a linear relation to one another, although the developing process itself is nonlinear caused by the holographic photopolymer. A mechano-optical modulator using a rotating optical flat is introduced to enable economic single-shot exposure of centimeter to decimeter-sized holograms utilizing only one laser. The modulator specifically suppresses undesired interference, which occurs with this type of simultaneous exposure. A device concept of the modulator is presented. The application to simultaneous holographic multiplexing is theoretically discussed and experimentally demonstrated. The experimental results are compared to simulations and are evaluated. The functionality and practicability are proven, giving rise to a new design concept and a wider range of applications.

  17. In-plant reliability data base for nuclear power plant components: data collection and methodology report

    International Nuclear Information System (INIS)

    Drago, J.P.; Borkowski, R.J.; Pike, D.H.; Goldberg, F.F.

    1982-07-01

    The development of a component reliability data for use in nuclear power plant probabilistic risk assessments and reliabiilty studies is presented in this report. The sources of the data are the in-plant maintenance work request records from a sample of nuclear power plants. This data base is called the In-Plant Reliability Data (IPRD) system. Features of the IPRD system are compared with other data sources such as the Licensee Event Report system, the Nuclear Plant Reliability Data system, and IEEE Standard 500. Generic descriptions of nuclear power plant systems formulated for IPRD are given

  18. On risk-based operation and maintenance of offshore wind turbine components

    DEFF Research Database (Denmark)

    Nielsen, Jannie Jessen; Sørensen, John Dalsgaard

    2011-01-01

    Operation and maintenance are significant contributors to the cost of energy for offshore wind turbines. Optimal planning could rationally be based on Bayesian pre-posterior decision theory, and all costs through the lifetime of the structures should be included. This paper contains a study...... of a generic case where the costs are evaluated for a single wind turbine with a single component. Costs due to inspections, repairs, and lost production are included in the model. The costs are compared for two distinct maintenance strategies, namely with and without inclusion of periodic imperfect...

  19. Reliability-based optimization of maintenance scheduling of mechanical components under fatigue.

    Science.gov (United States)

    Beaurepaire, P; Valdebenito, M A; Schuëller, G I; Jensen, H A

    2012-05-01

    This study presents the optimization of the maintenance scheduling of mechanical components under fatigue loading. The cracks of damaged structures may be detected during non-destructive inspection and subsequently repaired. Fatigue crack initiation and growth show inherent variability, and as well the outcome of inspection activities. The problem is addressed under the framework of reliability based optimization. The initiation and propagation of fatigue cracks are efficiently modeled using cohesive zone elements. The applicability of the method is demonstrated by a numerical example, which involves a plate with two holes subject to alternating stress.

  20. Automatic content extraction of filled-form images based on clustering component block projection vectors

    Science.gov (United States)

    Peng, Hanchuan; He, Xiaofeng; Long, Fuhui

    2003-12-01

    Automatic understanding of document images is a hard problem. Here we consider a sub-problem, automatically extracting content from filled form images. Without pre-selected templates or sophisticated structural/semantic analysis, we propose a novel approach based on clustering the component-block-projection-vectors. By combining spectral clustering and minimal spanning tree clustering, we generate highly accurate clusters, from which the adaptive templates are constructed to extract the filled-in content. Our experiments show this approach is effective for a set of 1040 US IRS tax form images belonging to 208 types.

  1. Simultaneous multicomponent spectrophotometric monitoring of methyl and propyl parabens using multivariate statistical methods after their preconcentration by robust ionic liquid-based dispersive liquid-liquid microextraction

    Science.gov (United States)

    Khani, Rouhollah; Ghasemi, Jahan B.; Shemirani, Farzaneh

    2014-03-01

    A powerful and efficient signal-preprocessing technique that combines local and multiscale properties of the wavelet prism with the global filtering capability of orthogonal signal correction (OSC) is applied for pretreatment of spectroscopic data of parabens as model compounds after their preconcentration by robust ionic liquid-based dispersive liquid-liquid microextraction method (IL-DLLME). In the proposed technique, a mixture of a water-immiscible ionic liquid (as extraction solvent) [Hmim][PF6] and disperser solvent is injected into an aqueous sample solution containing one of the IL's ions, NaPF6, as extraction solvent and common ion source. After preconcentration, the absorbance of the extracted compounds was measured in the wavelength range of 200-700 nm. The wavelet orthogonal signal correction with partial least squares (WOSC-PLS) method was then applied for simultaneous determination of each individual compound. Effective parameters, such as amount of IL, volume of the disperser solvent and amount of NaPF6, were inspected by central composite design to identify the most important parameters and their interactions. The effect of pH on the sensitivity and selectivity was studied according to the net analyte signal (NAS) for each component. Under optimum conditions, enrichment factors of the studied compounds were 75 for methyl paraben (MP) and 71 for propyl paraben (PP). Limits of detection for MP and PP were 4.2 and 4.8 ng mL-1, respectively. The root mean square errors of prediction for MP and PP were 0.1046 and 0.1275 μg mL-1, respectively. The practical applicability of the developed method was examined using hygienic, cosmetic, pharmaceutical and natural water samples.

  2. Infrared and visible image fusion based on robust principal component analysis and compressed sensing

    Science.gov (United States)

    Li, Jun; Song, Minghui; Peng, Yuanxi

    2018-03-01

    Current infrared and visible image fusion methods do not achieve adequate information extraction, i.e., they cannot extract the target information from infrared images while retaining the background information from visible images. Moreover, most of them have high complexity and are time-consuming. This paper proposes an efficient image fusion framework for infrared and visible images on the basis of robust principal component analysis (RPCA) and compressed sensing (CS). The novel framework consists of three phases. First, RPCA decomposition is applied to the infrared and visible images to obtain their sparse and low-rank components, which represent the salient features and background information of the images, respectively. Second, the sparse and low-rank coefficients are fused by different strategies. On the one hand, the measurements of the sparse coefficients are obtained by the random Gaussian matrix, and they are then fused by the standard deviation (SD) based fusion rule. Next, the fused sparse component is obtained by reconstructing the result of the fused measurement using the fast continuous linearized augmented Lagrangian algorithm (FCLALM). On the other hand, the low-rank coefficients are fused using the max-absolute rule. Subsequently, the fused image is superposed by the fused sparse and low-rank components. For comparison, several popular fusion algorithms are tested experimentally. By comparing the fused results subjectively and objectively, we find that the proposed framework can extract the infrared targets while retaining the background information in the visible images. Thus, it exhibits state-of-the-art performance in terms of both fusion effects and timeliness.

  3. Three-dimensional NDE of VHTR core components via simulation-based testing. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Guzina, Bojan [Univ. of Minnesota, Minneapolis, MN (United States); Kunerth, Dennis [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-09-30

    A next generation, simulation-driven-and-enabled testing platform is developed for the 3D detection and characterization of defects and damage in nuclear graphite and composite structures in Very High Temperature Reactors (VHTRs). The proposed work addresses the critical need for the development of high-fidelity Non-Destructive Examination (NDE) technologies for as-manufactured and replaceable in-service VHTR components. Centered around the novel use of elastic (sonic and ultrasonic) waves, this project deploys a robust, non-iterative inverse solution for the 3D defect reconstruction together with a non-contact, laser-based approach to the measurement of experimental waveforms in VHTR core components. In particular, this research (1) deploys three-dimensional Scanning Laser Doppler Vibrometry (3D SLDV) as a means to accurately and remotely measure 3D displacement waveforms over the accessible surface of a VHTR core component excited by mechanical vibratory source; (2) implements a powerful new inverse technique, based on the concept of Topological Sensitivity (TS), for non-iterative elastic waveform tomography of internal defects - that permits robust 3D detection, reconstruction and characterization of discrete damage (e.g. holes and fractures) in nuclear graphite from limited-aperture NDE measurements; (3) implements state-of-the art computational (finite element) model that caters for accurately simulating elastic wave propagation in 3D blocks of nuclear graphite; (4) integrates the SLDV testing methodology with the TS imaging algorithm into a non-contact, high-fidelity NDE platform for the 3D reconstruction and characterization of defects and damage in VHTR core components; and (5) applies the proposed methodology to VHTR core component samples (both two- and three-dimensional) with a priori induced, discrete damage in the form of holes and fractures. Overall, the newly established SLDV-TS testing platform represents a next-generation NDE tool that surpasses

  4. Three-dimensional NDE of VHTR core components via simulation-based testing. Final report

    International Nuclear Information System (INIS)

    Guzina, Bojan; Kunerth, Dennis

    2014-01-01

    A next generation, simulation-driven-and-enabled testing platform is developed for the 3D detection and characterization of defects and damage in nuclear graphite and composite structures in Very High Temperature Reactors (VHTRs). The proposed work addresses the critical need for the development of high-fidelity Non-Destructive Examination (NDE) technologies for as-manufactured and replaceable in-service VHTR components. Centered around the novel use of elastic (sonic and ultrasonic) waves, this project deploys a robust, non-iterative inverse solution for the 3D defect reconstruction together with a non-contact, laser-based approach to the measurement of experimental waveforms in VHTR core components. In particular, this research (1) deploys three-dimensional Scanning Laser Doppler Vibrometry (3D SLDV) as a means to accurately and remotely measure 3D displacement waveforms over the accessible surface of a VHTR core component excited by mechanical vibratory source; (2) implements a powerful new inverse technique, based on the concept of Topological Sensitivity (TS), for non-iterative elastic waveform tomography of internal defects - that permits robust 3D detection, reconstruction and characterization of discrete damage (e.g. holes and fractures) in nuclear graphite from limited-aperture NDE measurements; (3) implements state-of-the art computational (finite element) model that caters for accurately simulating elastic wave propagation in 3D blocks of nuclear graphite; (4) integrates the SLDV testing methodology with the TS imaging algorithm into a non-contact, high-fidelity NDE platform for the 3D reconstruction and characterization of defects and damage in VHTR core components; and (5) applies the proposed methodology to VHTR core component samples (both two- and three-dimensional) with a priori induced, discrete damage in the form of holes and fractures. Overall, the newly established SLDV-TS testing platform represents a next-generation NDE tool that surpasses

  5. Simultaneous ultrafiltration and diafiltration

    Directory of Open Access Journals (Sweden)

    Zavargo Zoltan Z.

    2002-01-01

    Full Text Available A model with simultaneous ultrafiltration and diafiltration, which includes the rejection coefficients, is presented in this study. Adding a diafiltration solution at a constant, lower rate than the filtrate rate results in a constant decrease of the solution volume in the tank. This enables the simultaneous attainment of the desired macrosolute concentration and microsulute dilution. The proposed model, based on incomplete macrosolute rejection and incomplete mi-crosolute permeation through a membrane, as well as constant permeate flux, is compared to the classical constant volume, diafiltration process. The obtained results show that less diafiltration volume is necessary with this process. Simultaneously, the duration of the process, for higher purification requirements, is shorter in this case.

  6. Mitochondrial phylogeny of the Chrysisignita (Hymenoptera: Chrysididae) species group based on simultaneous Bayesian alignment and phylogeny reconstruction.

    Science.gov (United States)

    Soon, Villu; Saarma, Urmas

    2011-07-01

    The ignita species group within the genus Chrysis includes over 100 cuckoo wasp species, which all lead a parasitic lifestyle and exhibit very similar morphology. The lack of robust, diagnostic morphological characters has hindered phylogenetic reconstructions and contributed to frequent misidentification and inconsistent interpretations of species in this group. Therefore, molecular phylogenetic analysis is the most suitable approach for resolving the phylogeny and taxonomy of this group. We present a well-resolved phylogeny of the Chrysis ignita species group based on mitochondrial sequence data from 41 ingroup and six outgroup taxa. Although our emphasis was on European taxa, we included samples from most of the distribution range of the C. ignita species group to test for monophyly. We used a continuous mitochondrial DNA sequence consisting of 16S rRNA, tRNA(Val), 12S rRNA and ND4. The location of the ND4 gene at the 3' end of this continuous sequence, following 12S rRNA, represents a novel mitochondrial gene arrangement for insects. Due to difficulties in aligning rRNA genes, two different Bayesian approaches were employed to reconstruct phylogeny: (1) using a reduced data matrix including only those positions that could be aligned with confidence; or (2) using the full sequence dataset while estimating alignment and phylogeny simultaneously. In addition maximum-parsimony and maximum-likelihood analyses were performed to test the robustness of the Bayesian approaches. Although all approaches yielded trees with similar topology, considerably more nodes were resolved with analyses using the full data matrix. Phylogenetic analysis supported the monophyly of the C. ignita species group and divided its species into well-supported clades. The resultant phylogeny was only partly in accordance with published subgroupings based on morphology. Our results suggest that several taxa currently treated as subspecies or names treated as synonyms may in fact constitute

  7. Recognition of grasp types through principal components of DWT based EMG features.

    Science.gov (United States)

    Kakoty, Nayan M; Hazarika, Shyamanta M

    2011-01-01

    With the advancement in machine learning and signal processing techniques, electromyogram (EMG) signals have increasingly gained importance in man-machine interaction. Multifingered hand prostheses using surface EMG for control has appeared in the market. However, EMG based control is still rudimentary, being limited to a few hand postures based on higher number of EMG channels. Moreover, control is non-intuitive, in the sense that the user is required to learn to associate muscle remnants actions to unrelated posture of the prosthesis. Herein lies the promise of a low channel EMG based grasp classification architecture for development of an embedded intelligent prosthetic controller. This paper reports classification of six grasp types used during 70% of daily living activities based on two channel forearm EMG. A feature vector through principal component analysis of discrete wavelet transform coefficients based features of the EMG signal is derived. Classification is through radial basis function kernel based support vector machine following preprocessing and maximum voluntary contraction normalization of EMG signals. 10-fold cross validation is done. We have achieved an average recognition rate of 97.5%. © 2011 IEEE

  8. Site-Specific Incorporation of Functional Components into RNA by an Unnatural Base Pair Transcription System

    Directory of Open Access Journals (Sweden)

    Rie Kawai

    2012-03-01

    Full Text Available Toward the expansion of the genetic alphabet, an unnatural base pair between 7-(2-thienylimidazo[4,5-b]pyridine (Ds and pyrrole-2-carbaldehyde (Pa functions as a third base pair in replication and transcription, and provides a useful tool for the site-specific, enzymatic incorporation of functional components into nucleic acids. We have synthesized several modified-Pa substrates, such as alkylamino-, biotin-, TAMRA-, FAM-, and digoxigenin-linked PaTPs, and examined their transcription by T7 RNA polymerase using Ds-containing DNA templates with various sequences. The Pa substrates modified with relatively small functional groups, such as alkylamino and biotin, were efficiently incorporated into RNA transcripts at the internal positions, except for those less than 10 bases from the 3′-terminus. We found that the efficient incorporation into a position close to the 3′-terminus of a transcript depended on the natural base contexts neighboring the unnatural base, and that pyrimidine-Ds-pyrimidine sequences in templates were generally favorable, relative to purine-Ds-purine sequences. The unnatural base pair transcription system provides a method for the site-specific functionalization of large RNA molecules.

  9. Principal Component Analysis in Grey Based Taguchi Method for Optimization of Multiple Surface Quality Characteristics of 6061-T4 Aluminum in CNC End Milling

    Science.gov (United States)

    Datta, Saurav; Routara, Bharat Chandra; Bandyopadhyay, Asish; Mahapatra, Siba Sankar

    2011-01-01

    The present study highlights a multi-objective optimization problem by applying Principal Component Analysis (PCA) coupled with grey based Taguchi method through a case study in CNC end milling of 6061-T4 Aluminum. The study aimed at evaluating the best process environment which could simultaneously satisfy multiple requirements of surface quality. In view of the fact, that traditional Taguchi method cannot solve a multi-objective optimization problem; to overcome this limitation, grey relation theory has been coupled with Taguchi method. Furthermore, to follow the basic assumption of Taguchi method i.e. quality attributes should be uncorrelated or independent; which is not always satisfied in practical situation. To overcome this shortcoming the study applied Principal Component analysis to eliminate response correlation and to evaluate independent or uncorrelated quality indices called Principal Components which were aggregated to compute an overall quality index denoted as overall grey relational grade which was optimized (minimized) finally. The study combined PCA and grey based Taguchi method for predicting optimal setting. Optimal result was verified through confirmatory test.

  10. The ultraviolet detection component based on Te-Cs image intensifier

    Science.gov (United States)

    Qian, Yunsheng; Zhou, Xiaoyu; Wu, Yujing; Wang, Yan; Xu, Hua

    2017-05-01

    Ultraviolet detection technology has been widely focused and adopted in the fields of ultraviolet warning and corona detection for its significant value and practical meaning. The component structure of ultraviolet ICMOS, imaging driving and the photon counting algorithm are studied in this paper. Firstly, the one-inch and wide dynamic range CMOS chip with the coupling optical fiber panel is coupled to the ultraviolet image intensifier. The photocathode material in ultraviolet image intensifier is Te-Cs, which contributes to the solar blind characteristic, and the dual micro-channel plates (MCP) structure ensures the sufficient gain to achieve the single photon counting. Then, in consideration of the ultraviolet detection demand, the drive circuit of the CMOS chip is designed and the corresponding program based on Verilog language is written. According to the characteristics of ultraviolet imaging, the histogram equalization method is applied to enhance the ultraviolet image and the connected components labeling way is utilized for the ultraviolet single photon counting. Moreover, one visible light video channel is reserved in the ultraviolet ICOMS camera, which can be used for the fusion of ultraviolet and visible images. Based upon the module, the ultraviolet optical lens and the deep cut-off solar blind filter are adopted to construct the ultraviolet detector. At last, the detection experiment of the single photon signal is carried out, and the test results are given and analyzed.

  11. Surface inspection system for industrial components based on shape from shading minimization approach

    Science.gov (United States)

    Kotan, Muhammed; Öz, Cemil

    2017-12-01

    An inspection system using estimated three-dimensional (3-D) surface characteristics information to detect and classify the faults to increase the quality control on the frequently used industrial components is proposed. Shape from shading (SFS) is one of the basic and classic 3-D shape recovery problems in computer vision. In our application, we developed a system using Frankot and Chellappa SFS method based on the minimization of the selected basis function. First, the specialized image acquisition system captured the images of the component. To eliminate noise, wavelet transform is applied to the taken images. Then, estimated gradients were used to obtain depth and surface profiles. Depth information was used to determine and classify the surface defects. Also, a comparison made with some linearization-based SFS algorithms was discussed. The developed system was applied to real products and the results indicated that using SFS approaches is useful and various types of defects can easily be detected in a short period of time.

  12. An adaptive neuro fuzzy model for estimating the reliability of component-based software systems

    Directory of Open Access Journals (Sweden)

    Kirti Tyagi

    2014-01-01

    Full Text Available Although many algorithms and techniques have been developed for estimating the reliability of component-based software systems (CBSSs, much more research is needed. Accurate estimation of the reliability of a CBSS is difficult because it depends on two factors: component reliability and glue code reliability. Moreover, reliability is a real-world phenomenon with many associated real-time problems. Soft computing techniques can help to solve problems whose solutions are uncertain or unpredictable. A number of soft computing approaches for estimating CBSS reliability have been proposed. These techniques learn from the past and capture existing patterns in data. The two basic elements of soft computing are neural networks and fuzzy logic. In this paper, we propose a model for estimating CBSS reliability, known as an adaptive neuro fuzzy inference system (ANFIS, that is based on these two basic elements of soft computing, and we compare its performance with that of a plain FIS (fuzzy inference system for different data sets.

  13. INCREMENTAL PRINCIPAL COMPONENT ANALYSIS BASED OUTLIER DETECTION METHODS FOR SPATIOTEMPORAL DATA STREAMS

    Directory of Open Access Journals (Sweden)

    A. Bhushan

    2015-07-01

    Full Text Available In this paper, we address outliers in spatiotemporal data streams obtained from sensors placed across geographically distributed locations. Outliers may appear in such sensor data due to various reasons such as instrumental error and environmental change. Real-time detection of these outliers is essential to prevent propagation of errors in subsequent analyses and results. Incremental Principal Component Analysis (IPCA is one possible approach for detecting outliers in such type of spatiotemporal data streams. IPCA has been widely used in many real-time applications such as credit card fraud detection, pattern recognition, and image analysis. However, the suitability of applying IPCA for outlier detection in spatiotemporal data streams is unknown and needs to be investigated. To fill this research gap, this paper contributes by presenting two new IPCA-based outlier detection methods and performing a comparative analysis with the existing IPCA-based outlier detection methods to assess their suitability for spatiotemporal sensor data streams.

  14. Combustion engine diagnosis model-based condition monitoring of gasoline and diesel engines and their components

    CERN Document Server

    Isermann, Rolf

    2017-01-01

    This book offers first a short introduction to advanced supervision, fault detection and diagnosis methods. It then describes model-based methods of fault detection and diagnosis for the main components of gasoline and diesel engines, such as the intake system, fuel supply, fuel injection, combustion process, turbocharger, exhaust system and exhaust gas aftertreatment. Additionally, model-based fault diagnosis of electrical motors, electric, pneumatic and hydraulic actuators and fault-tolerant systems is treated. In general series production sensors are used. It includes abundant experimental results showing the detection and diagnosis quality of implemented faults. Written for automotive engineers in practice, it is also of interest to graduate students of mechanical and electrical engineering and computer science. The Content Introduction.- I SUPERVISION, FAULT DETECTION AND DIAGNOSIS METHODS.- Supervision, Fault-Detection and Fault-Diagnosis Methods - a short Introduction.- II DIAGNOSIS OF INTERNAL COMBUST...

  15. Human Classification Based on Gestural Motions by Using Components of PCA

    International Nuclear Information System (INIS)

    Aziz, Azri A; Wan, Khairunizam; Za'aba, S K; Shahriman A B; Asyekin H; Zuradzman M R; Adnan, Nazrul H

    2013-01-01

    Lately, a study of human capabilities with the aim to be integrated into machine is the famous topic to be discussed. Moreover, human are bless with special abilities that they can hear, see, sense, speak, think and understand each other. Giving such abilities to machine for improvement of human life is researcher's aim for better quality of life in the future. This research was concentrating on human gesture, specifically arm motions for differencing the individuality which lead to the development of the hand gesture database. We try to differentiate the human physical characteristic based on hand gesture represented by arm trajectories. Subjects are selected from different type of the body sizes, and then acquired data undergo resampling process. The results discuss the classification of human based on arm trajectories by using Principle Component Analysis (PCA)

  16. A dark matter detector based on the simultaneous measurement of phonons and ionization at 20 mK

    Energy Technology Data Exchange (ETDEWEB)

    Shutt, Thomas Alan [UC, Berkeley

    1993-01-01

    One of the most important issues in astrophysics and cosmology is understanding the nature of dark matter. One possibility is that it is made of weakly interacting subatomic particles created in the big bang, such as the lightest particle in supersymmetry models. These particles should scatter elastically of nuclei in a detector on earth at a rate of ~events/kg/week, and will deposit energies of a few keV. Current attempts to detect these interactions are limited by a radioactive background of photons and beta particles which scatter on electrons. We have developed a novel particle detector to look for dark matter based on the simultaneous measurement of ionization and phonons in a 60 g crystal of high purity germanium at a temperature of 20 mK. Background events can be distinguished by our detector because they produce more ionization per unit phonon energy than dark matter interactions. The phonon energy is measured as a temperature change in the detector by means of neutron transmutation doped germanium thermistors attached to the crystal. The ionization measurement is accomplished by applying a bias to implanted contacts on the faces of the disk. Charge collection differs from the normal situation at 77 K in that no thermally generated free charge exists in the crystal at 20 mK. The collection efficiency is good with an electric field of only ~0.2 V/cm after the charged impurities in the crystal have been neutralized by free charge created by particle interactions from a radioactive source. For fields below this charge collection is poor, and affects the amount of phonon energy measured. We have modeled this in terms of charge trapping. The r.m.s resolution of the detector is 800 eV in phonons and 600 eV in ionization. We have tested the background rejection capability of the detector by exposing it to neutrons from a 251Cf source which scatter elastically on nuclei. The neutrons are distinguished at energies of a few keV, and the current background rejection

  17. Effects of intravenous solutions on acid-base equilibrium: from crystalloids to colloids and blood components.

    Science.gov (United States)

    Langer, Thomas; Ferrari, Michele; Zazzeron, Luca; Gattinoni, Luciano; Caironi, Pietro

    2014-01-01

    Intravenous fluid administration is a medical intervention performed worldwide on a daily basis. Nevertheless, only a few physicians are aware of the characteristics of intravenous fluids and their possible effects on plasma acid-base equilibrium. According to Stewart's theory, pH is independently regulated by three variables: partial pressure of carbon dioxide, strong ion difference (SID), and total amount of weak acids (ATOT). When fluids are infused, plasma SID and ATOT tend toward the SID and ATOT of the administered fluid. Depending on their composition, fluids can therefore lower, increase, or leave pH unchanged. As a general rule, crystalloids having a SID greater than plasma bicarbonate concentration (HCO₃-) cause an increase in plasma pH (alkalosis), those having a SID lower than HCO₃- cause a decrease in plasma pH (acidosis), while crystalloids with a SID equal to HCO₃- leave pH unchanged, regardless of the extent of the dilution. Colloids and blood components are composed of a crystalloid solution as solvent, and the abovementioned rules partially hold true also for these fluids. The scenario is however complicated by the possible presence of weak anions (albumin, phosphates and gelatins) and their effect on plasma pH. The present manuscript summarises the characteristics of crystalloids, colloids, buffer solutions and blood components and reviews their effect on acid-base equilibrium. Understanding the composition of intravenous fluids, along with the application of simple physicochemical rules best described by Stewart's approach, are pivotal steps to fully elucidate and predict alterations of plasma acid-base equilibrium induced by fluid therapy.

  18. Principal components analysis based control of a multi-dof underactuated prosthetic hand

    Directory of Open Access Journals (Sweden)

    Magenes Giovanni

    2010-04-01

    Full Text Available Abstract Background Functionality, controllability and cosmetics are the key issues to be addressed in order to accomplish a successful functional substitution of the human hand by means of a prosthesis. Not only the prosthesis should duplicate the human hand in shape, functionality, sensorization, perception and sense of body-belonging, but it should also be controlled as the natural one, in the most intuitive and undemanding way. At present, prosthetic hands are controlled by means of non-invasive interfaces based on electromyography (EMG. Driving a multi degrees of freedom (DoF hand for achieving hand dexterity implies to selectively modulate many different EMG signals in order to make each joint move independently, and this could require significant cognitive effort to the user. Methods A Principal Components Analysis (PCA based algorithm is used to drive a 16 DoFs underactuated prosthetic hand prototype (called CyberHand with a two dimensional control input, in order to perform the three prehensile forms mostly used in Activities of Daily Living (ADLs. Such Principal Components set has been derived directly from the artificial hand by collecting its sensory data while performing 50 different grasps, and subsequently used for control. Results Trials have shown that two independent input signals can be successfully used to control the posture of a real robotic hand and that correct grasps (in terms of involved fingers, stability and posture may be achieved. Conclusions This work demonstrates the effectiveness of a bio-inspired system successfully conjugating the advantages of an underactuated, anthropomorphic hand with a PCA-based control strategy, and opens up promising possibilities for the development of an intuitively controllable hand prosthesis.

  19. Principal component analysis based unsupervised feature extraction applied to budding yeast temporally periodic gene expression.

    Science.gov (United States)

    Taguchi, Y-H

    2016-01-01

    The recently proposed principal component analysis (PCA) based unsupervised feature extraction (FE) has successfully been applied to various bioinformatics problems ranging from biomarker identification to the screening of disease causing genes using gene expression/epigenetic profiles. However, the conditions required for its successful use and the mechanisms involved in how it outperforms other supervised methods is unknown, because PCA based unsupervised FE has only been applied to challenging (i.e. not well known) problems. In this study, PCA based unsupervised FE was applied to an extensively studied organism, i.e., budding yeast. When applied to two gene expression profiles expected to be temporally periodic, yeast metabolic cycle (YMC) and yeast cell division cycle (YCDC), PCA based unsupervised FE outperformed simple but powerful conventional methods, with sinusoidal fitting with regards to several aspects: (i) feasible biological term enrichment without assuming periodicity for YMC; (ii) identification of periodic profiles whose period was half as long as the cell division cycle for YMC; and (iii) the identification of no more than 37 genes associated with the enrichment of biological terms related to cell division cycle for the integrated analysis of seven YCDC profiles, for which sinusoidal fittings failed. The explantation for differences between methods used and the necessary conditions required were determined by comparing PCA based unsupervised FE with fittings to various periodic (artificial, thus pre-defined) profiles. Furthermore, four popular unsupervised clustering algorithms applied to YMC were not as successful as PCA based unsupervised FE. PCA based unsupervised FE is a useful and effective unsupervised method to investigate YMC and YCDC. This study identified why the unsupervised method without pre-judged criteria outperformed supervised methods requiring human defined criteria.

  20. A global distribution of the ignitability component of flammability based on climatic drivers

    Science.gov (United States)

    Karali, Anna; Fyllas, Nikolaos M.; Hatzaki, Maria; Giannakopoulos, Christos; Nastos, Panagiotis

    2017-04-01

    Fire regime is the result of complex interactions among ignition, topography, weather and vegetation. Even though the influence of vegetation varies regionally, it remains the only component that can be directly managed in order to reduce the negative impacts of wildland fires. Therefore, reliable information on vegetation flammability is required, making it one of the essential components of fire risk assessment and management. Specific Leaf Area (SLA [cm2 g-1], the ratio of leaf area to leaf dry mass) has received little attention regarding its relationship with ignitability and, thus, flammability. However, recent studies on a regional scale have shown that leaves of higher SLA are more ignitable. Thus, in the framework of the current study, the ignitability, as a function of SLA on global scale, is explored. In order to calculate SLA, a linear regression model combining SLA and climate data has been used (Maire et al., 2015). The climate data used for its calculation include the maximum monthly fractional sunshine duration, the maximum monthly temperature and the number of days with daily mean temperature above 0°C for each grid cell, obtained from the ERA-Interim gridded observations database. Subsequently, the ignitability component of flammability is calculated on a global scale using a bivariate regression relationship with SLA based on experimental burns of leaf materials (Grootemaat et al., 2015). The global distribution of ignitability can subsequently be combined with fire weather index (FWI) values for the development of an integrated index of forest fire vulnerability for the current and future climate, using CMIP5 climate model outputs. This will enable the integration of functional biogeographic data with widely applied fire risk assessment methodologies at regional to global spatial scales.

  1. Eight-component retrievals from ground-based MAX-DOAS observations

    Directory of Open Access Journals (Sweden)

    H. Irie

    2011-06-01

    Full Text Available We attempt for the first time to retrieve lower-tropospheric vertical profile information for 8 quantities from ground-based Multi-Axis Differential Optical Absorption Spectroscopy (MAX-DOAS observations. The components retrieved are the aerosol extinction coefficients at two wavelengths, 357 and 476 nm, and NO2, HCHO, CHOCHO, H2O, SO2, and O3 volume mixing ratios. A Japanese MAX-DOAS profile retrieval algorithm, version 1 (JM1, is applied to observations performed at Cabauw, the Netherlands (51.97° N, 4.93° E, in June–July 2009 during the Cabauw Intercomparison campaign of Nitrogen Dioxide measuring Instruments (CINDI. Of the retrieved profiles, we focus here on the lowest-layer data (mean values at altitudes 0–1 km, where the sensitivity is usually highest owing to the longest light path. In support of the capability of the multi-component retrievals, we find reasonable overall agreement with independent data sets, including a regional chemical transport model (CHIMERE and in situ observations performed near the surface (2–3 m and at the 200-m height level of the tall tower in Cabauw. Plumes of enhanced HCHO and SO2 were likely affected by biogenic and ship emissions, respectively, and an improvement in their emission strengths is suggested for better agreement between CHIMERE simulations and MAX-DOAS observations. Analysis of air mass factors indicates that the horizontal spatial representativeness of MAX-DOAS observations is about 3–15 km (depending mainly on aerosol extinction, comparable to or better than the spatial resolution of current UV-visible satellite observations and model calculations. These demonstrate that MAX-DOAS provides multi-component data useful for the evaluation of satellite observations and model calculations and can play an important role in bridging different data sets having different spatial resolutions.

  2. Experimental comparison between different configurations of PCM based heat sinks for cooling electronic components

    International Nuclear Information System (INIS)

    Gharbi, Salma; Harmand, Souad; Jabrallah, Sadok Ben

    2015-01-01

    The thermal control of electronic components is aimed at ensuring their use in a temperature range compatible with their performances. This paper presents an experimental study of the behavior of phase change materials (PCMs) as the cooling system for electronic devices. Four configurations are used to control the increase in the system temperature: pure PCM, PCM in a silicone matrix, PCM in a graphite matrix and pure PCM in a system of fins. Thermo-physical properties of different PCMs are determined and found to be desirable for application in this study. Solid liquid interface visualization and temperature evolution are employed to understand the mechanism of heat transfer during the different stages. Results indicated that the inclusion of PCM can lower component increase temperature and extends twice the critical time of the heat sink. The use of Graphite matrix filled by PCM showed more improvement on system thermal performance than silicon matrix. Also, for the same fraction of copper, it was found that incorporating long copper fins with suitable spacing into PCM, can enhance heat distribution into PCM leading to longer remain component temperature below the critical limit. This work therefore shows that the combination of PCM and long, well-spaced fins presents an effective means for thermal control of electronic devices. - Highlights: • Study on thermal performance of different PCM based heat sink in electronic cooling. • Examination of heat transfer mechanism into heat sink for different conditions. • Graphite matrix shows more efficiency than silicon. • Inclusion PCM can reduce temperature increasing. • Heat sink with longer well spaced fins can extend longer the critical time

  3. Membrane-Based Characterization of a Gas Component — A Transient Sensor Theory

    Directory of Open Access Journals (Sweden)

    Detlef Lazik

    2014-03-01

    Full Text Available Based on a multi-gas solution-diffusion problem for a dense symmetrical membrane this paper presents a transient theory of a planar, membrane-based sensor cell for measuring gas from both initial conditions: dynamic and thermodynamic equilibrium. Using this theory, the ranges for which previously developed, simpler approaches are valid will be discussed; these approaches are of vital interest for membrane-based gas sensor applications. Finally, a new theoretical approach is introduced to identify varying gas components by arranging sensor cell pairs resulting in a concentration independent gas-specific critical time. Literature data for the N2, O2, Ar, CH4, CO2, H2 and C4H10 diffusion coefficients and solubilities for a polydimethylsiloxane membrane were used to simulate gas specific sensor responses. The results demonstrate the influence of (i the operational mode; (ii sensor geometry and (iii gas matrices (air, Ar on that critical time. Based on the developed theory the case-specific suitable membrane materials can be determined and both operation and design options for these sensors can be optimized for individual applications. The results of mixing experiments for different gases (O2, CO2 in a gas matrix of air confirmed the theoretical predictions.

  4. Patterns and individual-based modeling of spatial competition within two main components of Neotropical mangrove ecosystems.

    OpenAIRE

    Piou, Cyril

    2007-01-01

    The main focus of the thesis was to look at the role of competition in shaping the spatial organization of two main components of Neotropical mangrove ecosystems. The first component was the Caribbean mangrove tree community. The second was populations of an ecologically and economically important mangrove burrowing crab in North-Brazil: Ucides cordatus. These two components were studied in two respective parts with one field and two individual-based modeling studies each. The two individual-...

  5. THz spectral data analysis and components unmixing based on non-negative matrix factorization methods

    Science.gov (United States)

    Ma, Yehao; Li, Xian; Huang, Pingjie; Hou, Dibo; Wang, Qiang; Zhang, Guangxin

    2017-04-01

    In many situations the THz spectroscopic data observed from complex samples represent the integrated result of several interrelated variables or feature components acting together. The actual information contained in the original data might be overlapping and there is a necessity to investigate various approaches for model reduction and data unmixing. The development and use of low-rank approximate nonnegative matrix factorization (NMF) and smooth constraint NMF (CNMF) algorithms for feature components extraction and identification in the fields of terahertz time domain spectroscopy (THz-TDS) data analysis are presented. The evolution and convergence properties of NMF and CNMF methods based on sparseness, independence and smoothness constraints for the resulting nonnegative matrix factors are discussed. For general NMF, its cost function is nonconvex and the result is usually susceptible to initialization and noise corruption, and may fall into local minima and lead to unstable decomposition. To reduce these drawbacks, smoothness constraint is introduced to enhance the performance of NMF. The proposed algorithms are evaluated by several THz-TDS data decomposition experiments including a binary system and a ternary system simulating some applications such as medicine tablet inspection. Results show that CNMF is more capable of finding optimal solutions and more robust for random initialization in contrast to NMF. The investigated method is promising for THz data resolution contributing to unknown mixture identification.

  6. THz spectral data analysis and components unmixing based on non-negative matrix factorization methods.

    Science.gov (United States)

    Ma, Yehao; Li, Xian; Huang, Pingjie; Hou, Dibo; Wang, Qiang; Zhang, Guangxin

    2017-04-15

    In many situations the THz spectroscopic data observed from complex samples represent the integrated result of several interrelated variables or feature components acting together. The actual information contained in the original data might be overlapping and there is a necessity to investigate various approaches for model reduction and data unmixing. The development and use of low-rank approximate nonnegative matrix factorization (NMF) and smooth constraint NMF (CNMF) algorithms for feature components extraction and identification in the fields of terahertz time domain spectroscopy (THz-TDS) data analysis are presented. The evolution and convergence properties of NMF and CNMF methods based on sparseness, independence and smoothness constraints for the resulting nonnegative matrix factors are discussed. For general NMF, its cost function is nonconvex and the result is usually susceptible to initialization and noise corruption, and may fall into local minima and lead to unstable decomposition. To reduce these drawbacks, smoothness constraint is introduced to enhance the performance of NMF. The proposed algorithms are evaluated by several THz-TDS data decomposition experiments including a binary system and a ternary system simulating some applications such as medicine tablet inspection. Results show that CNMF is more capable of finding optimal solutions and more robust for random initialization in contrast to NMF. The investigated method is promising for THz data resolution contributing to unknown mixture identification. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Development and characterization of two-component albedo based neutron individual monitoring system using thermoluminescent detectors

    International Nuclear Information System (INIS)

    Martins, Marcelo Marques

    2008-01-01

    A TLD-albedo based two-component neutron individual monitoring system was developed and characterized in this work. The monitor consists of a black plastic holder, an incident neutron boron loaded shield, a moderator polyethylene body (to increase its response), two pairs of TLD-600 and TLD-700 (one pair to each component) and an adjustable belt. This monitoring system was calibrated in thermal neutron fields and in 70 keV, 144 keV, 565 keV, 1.2 MeV and 5 MeV monoenergetic neutron fields. In addition, it was calibrated in 252C f(D 2 O), 252 Cf, 241 Am-B, 241 Am-Be and 238 Pu-Be source fields. For the latter, the lower detection levels are, respectively, 0.009 mSv, 0.06 mSv, 0.12 mSv, 0.09 mSv and 0.08 mSv. The participation in an international intercomparison sponsored by IAEA with simulated workplace fields validated the system. The monitoring system was successfully characterized in the ISO 21909 standard and in an IRD - the Brazilian Institute for Radioprotection and Dosimetry - technical regulation draft. Nowadays, the neutron individual system is in use by IRD for whole body individual monitoring of five institutions, which comprehend several activities. (author)

  8. Siloxane based Organic-Inorganic Hybrid Polymers and their Applications for Nanostructured Optical/Photonic Components

    Directory of Open Access Journals (Sweden)

    Rahmat Hidayat

    2014-11-01

    Full Text Available We have studied the preparation of organic-inorganic hybrid polymer precursors by sol-gel technique and their utilization for nanostructured optical components for photonic applications. The gel polymer precursors were prepared from siloxane modified by polymerizable acrylate groups, which can be processed further by photopolymerization process. Molecular structure characterizations by means of the FTIR measurements indicate the conversion of C=C bonds into C-C bonds after photopolymerization. This bond conversion produces high cross-linking between the organic and inorganic moieties, resulting in thermally stable and chemically resistant thin polymer layer which provide unique advantages of this material for particular optical/photonic applications. By employing laser interference technique, gratings with periodicity between 400-1000 nm have been successfully fabricated. Application of those sub-micron periodicity of grating structure as active elements in optically pumped polymer laser system and Surface Plasmon Resonance (SPR based measurement system have been also explored. The experimental results therefore also show the potential applications of this hybrid polymer as a building material for micro/nano-photonics components.

  9. A Component-Based Approach for Securing Indoor Home Care Applications

    Directory of Open Access Journals (Sweden)

    Aitor Agirre

    2017-12-01

    Full Text Available eHealth systems have adopted recent advances on sensing technologies together with advances in information and communication technologies (ICT in order to provide people-centered services that improve the quality of life of an increasingly elderly population. As these eHealth services are founded on the acquisition and processing of sensitive data (e.g., personal details, diagnosis, treatments and medical history, any security threat would damage the public’s confidence in them. This paper proposes a solution for the design and runtime management of indoor eHealth applications with security requirements. The proposal allows applications definition customized to patient particularities, including the early detection of health deterioration and suitable reaction (events as well as security needs. At runtime, security support is twofold. A secured component-based platform supervises applications execution and provides events management, whilst the security of the communications among application components is also guaranteed. Additionally, the proposed event management scheme adopts the fog computing paradigm to enable local event related data storage and processing, thus saving communication bandwidth when communicating with the cloud. As a proof of concept, this proposal has been validated through the monitoring of the health status in diabetic patients at a nursing home.

  10. A Component-Based Approach for Securing Indoor Home Care Applications.

    Science.gov (United States)

    Agirre, Aitor; Armentia, Aintzane; Estévez, Elisabet; Marcos, Marga

    2017-12-26

    eHealth systems have adopted recent advances on sensing technologies together with advances in information and communication technologies (ICT) in order to provide people-centered services that improve the quality of life of an increasingly elderly population. As these eHealth services are founded on the acquisition and processing of sensitive data (e.g., personal details, diagnosis, treatments and medical history), any security threat would damage the public's confidence in them. This paper proposes a solution for the design and runtime management of indoor eHealth applications with security requirements. The proposal allows applications definition customized to patient particularities, including the early detection of health deterioration and suitable reaction (events) as well as security needs. At runtime, security support is twofold. A secured component-based platform supervises applications execution and provides events management, whilst the security of the communications among application components is also guaranteed. Additionally, the proposed event management scheme adopts the fog computing paradigm to enable local event related data storage and processing, thus saving communication bandwidth when communicating with the cloud. As a proof of concept, this proposal has been validated through the monitoring of the health status in diabetic patients at a nursing home.

  11. An information system for the building industries: A communication approach based on industrial components

    Directory of Open Access Journals (Sweden)

    A F Cutting-Decelle

    2006-01-01

    Full Text Available This paper presents the SYDOX/MATCOMP/Xi project, funded by the French Ministry of Industry. The goal of the project was to provide the construction professionals with an on-line aid for component specification and selection at different levels of the construction life cycle. This two years project started in 1997 and involved several partners. This paper describes the main features of the information system: databases, query and communication systems. SYDOX(SYstème de DOnnées compleXes is aimed at defining and demonstrating a prototype to access information about MATerials and COMPonents used in construction, implemented on a WWW server. Though the objective is general, the work was focused on a restricted sub-section of the construction domain. We describe the domain and the scope of the project, the starting point and the lessons learnt from the development of the prototype. We also propose some important ideas on which this research is based.

  12. Feature extraction for ultrasonic sensor based defect detection in ceramic components

    Science.gov (United States)

    Kesharaju, Manasa; Nagarajah, Romesh

    2014-02-01

    High density silicon carbide materials are commonly used as the ceramic element of hard armour inserts used in traditional body armour systems to reduce their weight, while providing improved hardness, strength and elastic response to stress. Currently, armour ceramic tiles are inspected visually offline using an X-ray technique that is time consuming and very expensive. In addition, from X-rays multiple defects are also misinterpreted as single defects. Therefore, to address these problems the ultrasonic non-destructive approach is being investigated. Ultrasound based inspection would be far more cost effective and reliable as the methodology is applicable for on-line quality control including implementation of accept/reject criteria. This paper describes a recently developed methodology to detect, locate and classify various manufacturing defects in ceramic tiles using sub band coding of ultrasonic test signals. The wavelet transform is applied to the ultrasonic signal and wavelet coefficients in the different frequency bands are extracted and used as input features to an artificial neural network (ANN) for purposes of signal classification. Two different classifiers, using artificial neural networks (supervised) and clustering (un-supervised) are supplied with features selected using Principal Component Analysis(PCA) and their classification performance compared. This investigation establishes experimentally that Principal Component Analysis(PCA) can be effectively used as a feature selection method that provides superior results for classifying various defects in the context of ultrasonic inspection in comparison with the X-ray technique.

  13. Development of a skeletal multi-component fuel reaction mechanism based on decoupling methodology

    International Nuclear Information System (INIS)

    Mohan, Balaji; Tay, Kun Lin; Yang, Wenming; Chua, Kian Jon

    2015-01-01

    Highlights: • A compact multi-component skeletal reaction mechanism was developed. • Combined bio-diesel and PRF mechanism was proposed. • The mechanism consists of 68 species and 183 reactions. • Well validated against ignition delay times, flame speed and engine results. - Abstract: A new coupled bio-diesel surrogate and primary reference fuel (PRF) oxidation skeletal mechanism has been developed. The bio-diesel surrogate sub-mechanism consists of oxidation sub-mechanisms of Methyl decanoate (MD), Methyl 9-decenoate (MD9D) and n-Heptane fuel components. The MD and MD9D are chosen to represent the saturated and unsaturated methyl esters respectively in bio-diesel fuels. Then, a reduced iso-Octane oxidation sub-mechanism is added to the bio-diesel surrogate sub-mechanism. Then, all the sub-mechanisms are integrated to a reduced C 2 –C 3 mechanism, detailed H 2 /CO/C 1 mechanism and reduced NO x mechanism based on decoupling methodology. The final mechanism consisted of 68 species and 183 reactions. The mechanism was well validated with shock-tube ignition delay times, laminar flame speed and 3D engine simulations.

  14. Multifunctional Carbon-Based Metal-Free Electrocatalysts for Simultaneous Oxygen Reduction, Oxygen Evolution, and Hydrogen Evolution.

    Science.gov (United States)

    Hu, Chuangang; Dai, Liming

    2017-03-01

    Rationally designed N, S co-doped graphitic sheets with stereoscopic holes (SHG) act as effective tri-functional catalysts for the oxygen reduction reaction, hydrogen evolution reaction, and oxygen evolution reaction, simultaneously. The multifunctional electrocatalytic activities originate from a synergistic effect of the N, S heteroatom doping and unique SHG architecture, which provide a large surface area and efficient pathways for electron and electrolyte/reactant transports. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Effects of lipophilic components on the compatibility of lipid-based formulations with hard gelatin capsules.

    Science.gov (United States)

    Chen, Feng-Jing; Etzler, Frank M; Ubben, Johanna; Birch, Amy; Zhong, Li; Schwabe, Robert; Dudhedia, Mayur S

    2010-01-01

    The present study investigated the effect of lipophilic components on the compatibility of propylene glycol (PG)-containing lipid-based drug delivery system (LBDDS) formulations with hard gelatin capsules. The presence of a lipophilic active pharmaceutical ingredient (API) (log P approximately 6.1) and an additional lipophilic excipient (Capmul MCM) significantly affected the activity of PG in the fills and the equilibrium of PG between capsule shells and fills. These changes in activity and equilibrium of PG were furthermore correlated to the mechanical and thermal properties of the liquid-filled capsules and subsequently linked to the shelf-life of the capsules on stability with respect to capsule deformation. The present study also investigated the mechanism by which lipophilic component(s) might affect the activity of PG in the fill formulations and the equilibrium of PG between capsule shells and fills. The activities of PG in two series of "binary" mixtures with Capmul MCM and with Cremophor EL were measured, respectively. The mixtures of PG containing Capmul MCM were found to be more nearly ideal than those containing Cremophor EL. The observed negative deviation from Rauolt's law indicates that the excess free energies of mixing are less then zero indicating favorable interaction between PG and the other component. It is speculated that enhanced hydrogen bonding opportunities with Cremophor EL are responsible for the decreased excess free energy of mixing. Replacement of Cremophor EL with lipophilic API also reduces the hydrogen bonding opportunities for PG in the mixtures. This hypothesis may further explain the increased activity of PG in the fills and the shifted equilibrium of PG toward the capsule shells. Activity determination utilizing headspace gas chromatography (GC) using short 30 min incubation time seems to be a time-efficient approach for assessing capsule-fill compatibility. Direct measurements of PG migration and other physical properties of

  16. Harmonic Components Based Post-Filter Design for Residual Echo Suppression

    Science.gov (United States)

    Lee, Minwoo; Lee, Yoonjae; Kim, Kihyeon; Ko, Hanseok

    In this Letter, a residual acoustic echo suppression method is proposed to enhance the speech quality of hands-free communication in an automobile environment. The echo signal is normally a human voice with harmonic characteristics in a hands-free communication environment. The proposed algorithm estimates the residual echo signal by emphasizing its harmonic components. The estimated residual echo is used to obtain the signal-to-interference ratio (SIR) information at the acoustic echo canceller output. Then, the SIR based Wiener post-filter is constructed to reduce both the residual echo and noise. The experimental results confirm that the proposed algorithm is superior to the conventional residual echo suppression algorithm in terms of the echo return loss enhancement (ERLE) and the segmental signal-to-noise ratio (SEGSNR).

  17. Application of feal intermetallic phase matrix based alloys in the turbine components of a turbocharger

    Directory of Open Access Journals (Sweden)

    J. Cebulski

    2015-01-01

    Full Text Available This paper presents a possible application of the state-of-the-art alloys based on the FeAl intermetallic phases as materials for the manufacture of heat-proof turbine components in an automobile turbocharger. The research was aimed at determining the resistance to corrosion of Fe40Al5CrTiB alloy in a gaseous environment containing 9 % O2 + 0,2 % HCl + 0,08 % SO2 + N2. First the kinetics of corrosion processes for the considered alloy were determined at the temperatures of 900 °C, 1 000 °C and 1 100 °C, which was followed by validation under operating conditions. To do so, the tests were carried out over a distance of 20 000 km. The last stage involved examination of the surfaces after the test drive. The obtained results are the basis for further research in this field.

  18. An improved principal component analysis based region matching method for fringe direction estimation

    Science.gov (United States)

    He, A.; Quan, C.

    2018-04-01

    The principal component analysis (PCA) and region matching combined method is effective for fringe direction estimation. However, its mask construction algorithm for region matching fails in some circumstances, and the algorithm for conversion of orientation to direction in mask areas is computationally-heavy and non-optimized. We propose an improved PCA based region matching method for the fringe direction estimation, which includes an improved and robust mask construction scheme, and a fast and optimized orientation-direction conversion algorithm for the mask areas. Along with the estimated fringe direction map, filtered fringe pattern by automatic selective reconstruction modification and enhanced fast empirical mode decomposition (ASRm-EFEMD) is used for Hilbert spiral transform (HST) to demodulate the phase. Subsequently, windowed Fourier ridge (WFR) method is used for the refinement of the phase. The robustness and effectiveness of proposed method are demonstrated by both simulated and experimental fringe patterns.

  19. Mechanical properties of multifunctional structure with viscoelastic components based on FVE model

    Science.gov (United States)

    Hao, Dong; Zhang, Lin; Yu, Jing; Mao, Daiyong

    2018-02-01

    Based on the models of Lion and Kardelky (2004) and Hofer and Lion (2009), a finite viscoelastic (FVE) constitutive model, considering the predeformation-, frequency- and amplitude-dependent properties, has been proposed in our earlier paper [1]. FVE model is applied to investigating the dynamic characteristics of the multifunctional structure with the viscoelastic components. Combing FVE model with the finite element theory, the dynamic model of the multifunctional structure could be obtained. Additionally, the parametric identification and the experimental verification are also given via the frequency-sweep tests. The results show that the computational data agree well with the experimental data. FVE model has made a success of expressing the dynamic characteristics of the viscoelastic materials utilized in the multifunctional structure. The multifunctional structure technology has been verified by in-orbit experiments.

  20. [Establishment of industry promotion technology system in Chinese medicine secondary exploitation based on "component structure theory"].

    Science.gov (United States)

    Cheng, Xu-Dong; Feng, Liang; Zhang, Ming-Hua; Gu, Jun-Fei; Jia, Xiao-Bin

    2014-10-01

    The purpose of the secondary exploitation of Chinese medicine is to improve the quality of Chinese medicine products, enhance core competitiveness, for better use in clinical practice, and more effectively solve the patient suffering. Herbs, extraction, separation, refreshing, preparation and quality control are all involved in the industry promotion of Chinese medicine secondary exploitation of industrial production. The Chinese medicine quality improvement and industry promotion could be realized with the whole process of process optimization, quality control, overall processes improvement. Based on the "component structure theory", "multi-dimensional structure & process dynamic quality control system" and systematic and holistic character of Chinese medicine, impacts of whole process were discussed. Technology systems of Chinese medicine industry promotion was built to provide theoretical basis for improving the quality and efficacy of the secondary development of traditional Chinese medicine products.