WorldWideScience

Sample records for based dtpa derivative

  1. Redesign of negatively charged111In-DTPA-octreotide derivative to reduce renal radioactivity.

    Science.gov (United States)

    Oshima, Nobuhiro; Akizawa, Hiromichi; Kawashima, Hidekazu; Zhao, Songji; Zhao, Yan; Nishijima, Ken-Ichi; Kitamura, Yoji; Arano, Yasushi; Kuge, Yuji; Ohkura, Kazue

    2017-05-01

    Radiolabeled octreotide derivatives have been studied as diagnostic and therapeutic agents for somatostatin receptor-positive tumors. To prevent unnecessary radiation exposure during their clinical application, the present study aimed to develop radiolabeled peptides which could reduce radioactivity levels in the kidney at both early and late post-injection time points by introducing a negative charge with an acidic amino acid such as L-aspartic acid (Asp) at a suitable position in 111 In-DTPA-conjugated octreotide derivatives. Biodistribution of the radioactivity was evaluated in normal mice after administration of a novel radiolabeled peptide by a counting method. The radiolabeled species remaining in the kidney were identified by comparing their HPLC data with those obtained by alternative synthesis. The designed and synthesized radiolabeled peptide 111 In-DTPA-d-Phe -1 -Asp 0 -d-Phe 1 -octreotide exhibited significantly lower renal radioactivity levels than those of the known 111 In-DTPA-d-Phe 1 -octreotide at 3 and 24h post-injection. The radiolabeled species in the kidney at 24h after the injection of new octreotide derivative represented 111 In-DTPA-d-Phe-OH and 111 In-DTPA-d-Phe-Asp-OH as the metabolites. Their radiometabolites and intact 111 In-DTPA-conjugated octreotide derivative were observed in urine within 24h post-injection. The present study provided a new example of an 111 In-DTPA-conjugated octreotide derivative having the characteristics of both reduced renal uptake and shortened residence time of radioactivity in the kidney. It is considered that this kinetic control was achieved by introducing a negative charge on the octreotide derivative thereby suppressing the reabsorption in the renal tubules and affording the radiometabolites with appropriate lipophilicity. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Development and biodistrubition modeling of 99mTc-DTPA

    Directory of Open Access Journals (Sweden)

    Mohammed Bricha

    2015-09-01

    Full Text Available Purpose: In this study, the team modeled the biodistribution and the efficiency of two 99m-technetium diethylene triamine penta acetate (99mTc-DTPA based radiopharmaceuticals.Methods: The first radiopharmaceutical (DTPA-CNESTEN is developed at the laboratories of the radiopharmaceutical production unit of the National Center for Nuclear Energy, Sciences and Technologies (CNESTEN-Morocco, and the second one is the commercial DTPA (DTPA-ref. Freeze-dried kits were successfully radiolabeled (radiochemical purity >95% with the 99m Tc. Then drugs were injected to male BALB/c mice. In each 2 min, 5 min, 15 min, 1 h and 2 h time points after injections we evaluate tissue’s distributions characteristics. At the end, an automatic modeling of the data were recorded from thyroid, blood and urinary excretion kinetics and biodistribution in mice using both DTPA kits. The study aimed to extract the parameters of the function used to fit the recorded data. Results and Conclusion: the team concluded that the biodistribution of 99mTc-DTPA can be modeled using a combination of two exponential parts. Moreover, the resultant plots showed that there is strong correlation between the formula found in literature and the one derived on the basis of the fit of data sets in this study. In addition, it was found that the biodistribution behaviors of the developed kit and the commercial one were very close. The obtained results suggest that the developed DTPA has practically the same kinetics as the commercial one.

  3. Studies on Am(III) separation from simulated high-level waste using cobalt bis(dicarbollide) (1(-)) ion derivative covalently bound to N,N'-di-n-octyl diglycol diamide as extractant and DTPA as stripping agent

    Czech Academy of Sciences Publication Activity Database

    Bubeníková, M.; Selucký, P.; Rais, J.; Grüner, Bohumír; Švec, Petr

    2012-01-01

    Roč. 293, č. 1 (2012), s. 403-408 ISSN 0236-5731 R&D Projects: GA ČR GA104/09/0668 Institutional research plan: CEZ:AV0Z40320502 Keywords : Solvent extraction * actinides * high-level liquid waste * dicarbollide derivatives * carboranes * TODGA * DTPA Subject RIV: CA - Inorganic Chemistry Impact factor: 1.467, year: 2012

  4. r1 and r2 Relaxivities of Dendrons Based on a OEG-DTPA Architecture: Effect of Gd3+ Placement and Dendron Functionalization

    International Nuclear Information System (INIS)

    Fransen, P.; Simon-Gracia, L.; Albericio, F.; Fransen, P.; Pulido, D.; Simon-Gracia, L.; Candiata, A.P.; Arus, C.; Albericio, F.; Royo, M.; Pulido, D.; Royo, M.; Candiata, A.P.; Arus, C.; Candiata, A.P.; Albericio, F.; Candiata, A.P.

    2015-01-01

    In magnetic resonance imaging, contrast agents are employed to enhance the signal intensity. However, current commercial contrast agents are hindered by a low relaxivity constant. Dendrimers can be employed to create higher molecular weight contrast agents which have an increased relaxivity due to a lower molecular rotation. In this study, dendrimers containing DTPA derivatives as cores and/or branching units were used to chelate gadolinium ions. Locating the gadolinium ions inside the dendrimers results in higher relaxivity constants, possibly because the paramagnetic center is closer to the rotational axis of the macromolecule. The highest gain in relaxivity was produced by decorating the dendron surface with peptide sequences, which could be explained by the presence of more second-sphere water molecules attracted by the peptides. These findings could contribute to the development of more effective contrast agents, either by placing the paramagnetic gadolinium ion in a strategic position or through functionalization of the dendron surface.

  5. Model-based comparison of maternal and foetal organ doses from 99mTc pertechnetate, DMSA, DTPA, HDP, MAA and MAG3 diagnostic intakes during pregnancy

    International Nuclear Information System (INIS)

    Saunders, Margaret; Palmer, Maria; Preece, Alan; Millard, Roger

    2002-01-01

    Organ residence times were calculated for diagnostic intakes of 99m Tc pertechnetate, 2,3-dimercaptosuccinic acid (DMSA), diethylene triamine penta-acetic acid (DTPA), hydroxymethylene diphosphonate (HDP), macroaggregated albumin (MAA) and mercapto-acetyltriglycine (MAG 3 ) during the 1st and 3rd stages of pregnancy and used with the MIRDOSE3 pregnant female phantoms for generation of dose estimates. At stage 3 individual foetal organ doses were estimated via a surrogate phantom based on that for the new-born but with mean dose/cumulated activity (S) values scaled for compatibility with foetal whole body S. Stage 1 or 3 whole foetus doses ranged from 5.2 to 0.77 μGy MBq -1 respectively, analogous to current ICRP estimates for these agents using similar in vivo biodistribution model databases. Most stage 3 maternal and foetal organ doses were similar within a factor of 3, being higher in the foetus than the mother with pertechnetate, DTPA and MAG 3 , and lower with DMSA, HDP and MAA. Doses were more uniformly distributed among foetal organs than in the mother. Placental transfer was greatest with pertechnetate, where dose to the stage 3 foetal thyroid was 60-140 μGy MBq -1 . With each agent there was more placental transfer in stage 3 than in stage 1, but doses to stage 1 whole foetus were always higher, with the contribution from the mother dominant. For DMSA, HDP and MAG 3 the maternal contribution to total foetal body dose exceeded 93% for both stages. (orig.)

  6. Behavior of Gd-DTPA in simulated bank filtration

    Energy Technology Data Exchange (ETDEWEB)

    Moeller, Peter, E-mail: pemoe@gfz-potsdam.de [Freie Universitaet Berlin, Malteserstr. 74-100, AB Hydrogeologie, 12249 Berlin (Germany)] [Helmholtz Zentrum Potsdam, Deutsches GeoForschungsZentrum, Telegrafenberg, 14473 Potsdam (Germany); Knappe, Andrea [Freie Universitaet Berlin, Malteserstr. 74-100, AB Hydrogeologie, 12249 Berlin (Germany); Dulski, Peter [Helmholtz Zentrum Potsdam, Deutsches GeoForschungsZentrum, Telegrafenberg, 14473 Potsdam (Germany); Pekdeger, Asaf [Freie Universitaet Berlin, Malteserstr. 74-100, AB Hydrogeologie, 12249 Berlin (Germany)

    2011-01-15

    Research highlights: {yields} Gd-DTPA and similar products are common pollutants in surface and groundwater and prove to be a reliable monitor for mixing of groundwater with surface water loaded with effluents from sewage treatment plants. {yields} Within a 30 m column filled with Pleistocene sand Gd-DTPA is reduced by 16% only within one month time by transmetallation. {yields} Artificial bank filtration is not very effective in reducing Gd-DTPA in infiltrating water. - Abstract: The behavior of Gd-DTPA during bank filtration was simulated in a 30 m column filled with Pleistocene sand and flushed by surface water from a lakeside in Berlin, Germany. The surface water is about a 1:1 mixture of river water and effluents from a sewage treatment plant. Throughout 34 days this water was continuously spiked with Gd-DTPA at a level of 60 {mu}g/L. The broad plateau of the Gd-DTPA pulse declined by 15.4% within 34 days by transmetallation. Nine percentage of the total decline is caused by Y and rare earth elements; the remaining part is attributed to Cu{sup 2+} which is the most influential metal in surface water. All other metals also contributing to transmetallation are combined with Cu to Cu equivalents because only the rate constant of transmetallation of Cu{sup 2+} is known. The analytical results of the column effluents prove the pseudo-first-order kinetics of transmetallation based on reversible sorption of metals by pools in the column sediment and disprove biodegradation at noticeable levels. The mass ratio of water to tracer is <10{sup 10}.

  7. MR cisternography after intrathecal Gd-DTPA application

    International Nuclear Information System (INIS)

    Reiche, Werner; Komenda, Yvonne; Steudel, Wolf-Ingo; Schick, Bernhard; Grunwald, Iris; Reith, Wolfgang

    2002-01-01

    The purpose of this study was to establish and to evaluate MR cisternography after intrathecal Gd-DTPA administration to detect rhinobasal cerebrospinal fluid (CSF) fistulae in patients with suspected CSF rhinorrhoea. Ten patients with suspected CSF rhinorrhoea were examined. The MR cisternography included the following investigation steps: acquisition of nonenhanced fat-suppressed T1-weighted spin-echo (SE) scans of the skull base and the paranasal sinuses, lumbar puncture with administration of 1 ml Gd-DTPA solute with 4 ml NaCl and performance of MR cisternography with the same fat-suppressed T1-weighted sequences as used initially. In 10 patients with suspected CSF rhinorrhoea Gd-DTPA enhanced MR cisternography detected 5 CSF fistulae. In 3 of 5 CSF leaks were located in the cribriform plate and in 2 of 5 sphenoidal. Whereas 4 of these depicted leaks were confirmed surgically, in 1 case the CSF fistula closed spontaneously. In another case, CSF leakage after severe head injury was clinically highly suspected but ceased prior to MR cisternography with inability to detect the temporary fistula. In the remaining 4 patients with serous rhinorrhoea MR cisternography did not provide any evidences for CSF fistulae. Intrathecal Gd-DTPA injection was tolerated excellently. Clinical and EEG examinations showed no gross behavioural or neurological disturbances and no seizure activity, respectively. The MR cisternography after intrathecal administration of Gd-DTPA represents a safe, promising and minimally invasive method for detection of CSF fistulae. This MR investigation provides excellent depiction of CSF spaces and pinpoints CSF fistulae. (orig.)

  8. Comparison of the biodistribution of manganese-54 DTPA and gadolinium-153 DTPA in dogs

    Energy Technology Data Exchange (ETDEWEB)

    Boudreau, R.J.; Burbidge, S.; Sirr, S.; Loken, M.K.

    1987-03-01

    The biodistribution of (/sup 54/Mn)DTPA and (/sup 153/Gd)DTPA dimeglumine were investigated and compared following i.v. administration to fasting anesthetized dogs. Unlike most previously reported metal ion-DTPA complexes, (/sup 54/Mn)DTPA showed high uptakes in several organs including the liver, bile, pancreas, bowel, and kidney. This uptake was independent of the pH of the injected solution. Accumulation in these organs suggests a potential role for (Mn)DTPA as a paramagnetic contrast agent for NMR imaging. With the exception of the kidneys, (/sup 153/Gd)DTPA showed no evidence of tissue specific uptake over the course of 4 hr, consistent with it being an extracellular ion that is cleared by glomerular filtration.

  9. [Acellular vaccines (DTPa/dTpa) against whooping cough, protection duration].

    Science.gov (United States)

    Rigo-Medrano, M Vicenta; Mendoza-García, José L; Gimeno-Gascón, Adelina; Roda-Ramón, Jorge; Cremades-Bernabeú, Israel; Antequera-Rodríguez, Pedro; Alcalá-Minagorre, Pedro J; Ortiz-de la Tabla, Victoria; Rodríguez-Díaz, Juan Carlos

    2016-01-01

    An increase in whooping cough in most of the developed countries has been detected in the last decade. To determine whether the administration of dTpa vaccine instead of DTPa fifth dose is contributing to the appearance of these cases. A descriptive study based on cases of whooping cough reported during an epidemic period in the city of Alicante in the first 5 months of 2014. Only pertussis cases confirmed by PCR were included in the study, and only those vaccinated with 5 doses were included in the analysis of the period of protection. A total of 104 cases of pertussis confirmed by PCR were reported, with 85 cases (82%) having had 5 doses of vaccine. The mean time and standard deviation (SD) of protection was 2.1±1.1 years with dTpa, and 5.1±1.5 years with DTPa (p<.001). In the protection, adjusted for age, it was observed that, after 3 years, only 47.6% of people vaccinated with dTpa were still protected, while people vaccinated with DTPa were 100% protected (P<.001). This study found that people who were properly vaccinated against pertussis and received their last re-vaccination dose with dTpa had a shorter period of protection than those who were vaccinated with DTPa. Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  10. Financial Derivatives (Based on Two Supports Evaluation

    Directory of Open Access Journals (Sweden)

    Tiberiu Socaciu

    2016-07-01

    Full Text Available In this paper we build a PDE like Black-Scholes equation in hypothesis of a financial derivative that is dependent on two supports (usual is dependent only on one support, like amoption based on gold, when national currency has a great float.Keywords: Financial derivatives, derivatives evaluation, derivatives based on two supports, extended Itō like lemma.

  11. A study on preparation of new core [99mTc (CO)2 (NO)]2+ and its derivatives [99mTc (CO)2 (NO)-L] (L=DTPA/DETA/EHIDA) in aqueous solution

    International Nuclear Information System (INIS)

    Liu Jingying; Yang Yang; Qiao Jinping; Zhu Lin

    2008-01-01

    Two different procedures for preparation of [ 99m Tc(CO) 2 (NO)-L] (L=DTPA/EDTA/EHIDA) complexes was developed in aqueous solution: one is formation of the metal-tricarbonyl-ligand complex and subsequent nitrosylation; another is nitrosylation of the metal-tricarbonyl precursor followed by reaction with the ligand. Results of TLC and HPLC indicate that the radiochemical yield of all radiolabeled compounds is more than 90%. It's a easier new way to prepare [ 99m Tc(CO) 2 (NO)-L] complexes in aqueous solution with high efficiency. The lipophility and net charge of [ 99m Tc(CO) 2 (NO)-L] complexes also change. It provides a new method for designing radiopharmaceuticals. (authors)

  12. Modelling Pu/Am decorporation by DTPA

    International Nuclear Information System (INIS)

    Fritsch, P.; Serandour, A.L.; Gremy, O.; Le Gall, B.; Poncy, J.L.; Phan, G.; Benech, H.; Tsapis, N.; Fattal, E.; Deverre, J.R.; Blanchin, N.; Grappin, L.; Blanchardon, E.; Breustedt, B.

    2009-01-01

    A new tool has been developed to optimize DTPA efficacy as concerns reduction of effective dose after 239 Pu wound. For example, the simulations show, for moderately soluble compounds (type M), a 1/3 decrease of effective dose is obtained after repeated early treatment (24 i.v. for 4 months), whereas a decrease by a factor 5 can be reached if treatments continue for 5 years at 2 week interval. By contrast, for poorly soluble compounds (type S), negligible efficacy is observed after early treatments, and a 3 time decrease of dose is obtained for treatments performed at 2 week interval for 50 years. Some of the hypotheses retained for modelling DTPA decorporation are validated from new experimental data published recently, and structure of a new model which can be applied both to Pu and Am is reported, taking into account urinary and faecal excretion, structure being suitable for different doses of DTPA and using various galenic forms. (authors)

  13. Continuous measurement of DTPA-clearance in extracorporeal detoxification circuits.

    Science.gov (United States)

    Falkenhagen, D; Ahrenholz, P; Roy, T; Esther, G; Kiencke, H; Klinkmann, H

    1981-01-01

    A new method for investigating clearances is described. DTPA labelled with technetium 99m (MW: 496 daltons) is used as an agent to be measured. Continuous determination of the DTPA-clearance is possible in extracorporeal detoxification circuits including dialyzers, hemofilters and hemoperfusion columns. As an example, DTPA-clearances are given for two different dialyzers. In comparison to clearance measurements of peak 7, DTPA-clearance was very similar to that obtained for peak 7.

  14. Continuous measurement of DTPA-clearance in extracorporeal detoxification circuits

    Energy Technology Data Exchange (ETDEWEB)

    Falkenhagen, D.; Ahrenholz, P.; Roy, T.; Esther, G.; Kiencke, H.; Klinkmann, H.

    1981-01-01

    A new method for investigating clearances is described. DTPA labelled with technetium 99m (MW: 496 daltons) is used as an agent to be measured. Continuous determination of the DTPA-clearance is possible in extracorporeal detoxification circuits including dialyzers, hemofilters and hemoperfusion columns. As an example, DTPA-clearances are given for two different dialyzers. In comparison to clearance measurements of peak 7, DTPA-clearance was very similar to that obtained for peak 7.

  15. Clinical utility of Gd-DTPA subtraction MR imaging for spinal bone metastasis

    International Nuclear Information System (INIS)

    Ando, Keiichi; Murakami, Masao; Kuroda, Yasumasa

    1993-01-01

    Based on reports that Gd-DTPA contributes to the detection of tumors, we used it in 31 cases (97 lesions) of spinal bone metastases. The result was that Gd-DTPA increased the intensity of tumors and the surrounding bone marrow to almost the same level in 53%. To show the metastases clearly, an existing subtraction command system was utilized. The technique included the pixel-by-pixel method, to obtain a Gd-DTPA T1-weighted image (T1WI) subtracted by the original T1WI. The detectability of the subtraction image was improved up to 96%, but was less than the original T1WI (99%). Because of the different imaging rationale between two methods, a means to assess the quality of diagnosis must be proposed. To check the normal background, the same kind of postprocessing was performed in 21 patients without malignancy. Gd-DTPA prefusion was highest in the paravertebral veins, moderate in muscles and epidural fat, and lowest in the spinal cord, intervertebral disk and bone cortex. Gd-DTPA enhanced subtraction MR imaging provides a new diagnostic tool to detect and to assess bone metastasis. (author)

  16. Potential synergy between two renal toxicants: DTPA and uranium

    International Nuclear Information System (INIS)

    Muller, D.; Houpert, P.; Henge Napoli, M.H.; Paquet, F.; Muller, D.; Henge Napoli, M.H.; Metivier, H.

    2006-01-01

    At present, the most appropriate therapeutic approach to treat an accidental contamination with plutonium and uranium oxide mixture (MOX) is administration of diethylene-triamine-penta-acetate acid (DTPA) in order to accelerate plutonium excretion. As uranium and DTPA are both nephro-toxic compounds, the administration of DTPA after a contamination containing uranium could enhance the nephro-toxic effects of uranium. The aim of the present work was to study in vitro on a kidney proximal tubule cell line (LLC-PK 1 ) the cytotoxicity induced by increasing concentrations of uranium in presence of 3 different chemical forms of DTPA. The results showed that the DTPA used alone induced no cytotoxicity at the concentration used here (420 μM). However, this concentration of DTPA increased the cytotoxicity induced by uranium. This increase was maximal for uranium concentrations close to the lethal concentration for 50% of the cells and reached 37, 31 and 28% for anhydrous DTPA, Na 3 CaDTPA and Na 3 ZnDTPA, respectively. These results suggest that administration of DTPA could enhance the nephrotoxicity induced by uranium. (authors)

  17. Action of DTPA on hepatic plutonium. II. DTPA-induced removal of monomeric plutonium from mouse liver parenchymal cells

    International Nuclear Information System (INIS)

    Bhattacharyya, M.H.; Peterson, D.P.; Lindenbaum, A.

    1978-01-01

    Liver parenchymal cells were isolated 6 and 24 hr following the administration of diethylenetriaminepentaacetic acid (DTPA, 0.25 mmole/kg) to mice previously injected with 239 Pu-citrate (4.4 μCi/kg). Isolated parenchymal cells contained 440 dpm Pu/10 6 cells at 24 hr after Pu injection, just prior to DTPA administration. The PU content decreased to 330 dpm/10 6 cells at 6 hr and 140 dpm/10 6 cells at 24 hr after DTPA administration. Thus DTPA induced a striking decrease in the Pu content of isolated liver parenchymal cells. Parenchymal cells isolated from control mice not treated with DTPA changed little in Pu content from 24 to 48 hr after Pu injection. By 24 hr after DTPA treatment, the decrease in the Pu content of isolated liver parenchymal cells could account for the DTPA-induced release of Pu from the intact liver. Thus in the liver DTPA appears to act preferentially on the Pu associated with parenchymal cells. Liver parenchymal cells isolated 6 hr after DTPA administration and containing 330 dpm Pu/10 6 cells were incubated in vitro in the absence of added DTPA. After 18 hr of incubation the cells contained 130 dpm Pu/10 6 cells. This level corresponds to the level observed in cells isolated 24 hr after DTPA administration. Cells isolated from untreated mice lost only 15% of their Pu content during a similar in vitro incubation. Thus, by 6 hr after DTPA administration to the mouse, isolated liver parenchymal cells appeared to retain their ability to release Pu in vitro with no need for additional exposure to DTPA. The physiological significance of this finding is discussed

  18. Excretion of DTPA from human body and the effect of DTPA on the excretion of 241Am in urine

    International Nuclear Information System (INIS)

    Jia Guogang; Lu Ying; Bai Guang; Yu Yaoxian

    1988-01-01

    The excretion of DTPA in urine was studied after intramuscular injection or inhalation as an aerosol. For two administration of DTPA, the excretion fraction of DTPA in urine can be described by sum of two exponent functions. For intramuscular injection, the fast removal part is about 97% of all the activity administered with a half-life of 88 minutes; the slow removal part is about 3% with a half-life of 292 minutes; the excretion rate of DTPA within 24 hours is about 99%. For inhalation of DTPA, the fast removal part is about 81% with a half-life of 92 minutes; the slow removal part is about 19% with a half-life of 624 minutes. The therapeutic effect of DTPA on 241 Am is good, the average excretion of 241 Am in urine after treatment is 18 times more than that before treatment

  19. Derivation of GFDM Based on OFDM Principles

    Energy Technology Data Exchange (ETDEWEB)

    Hussein Moradi; Behrouz Farhang-Boroujeny

    2015-06-01

    This paper starts with discussing the principle based on which the celebrated orthogonal frequency division multiplexing (OFDM) signals are constructed. It then extends the same principle to construct the newly introduced generalized frequency division multiplexing (GFDM) signals. This novel derivation sheds light on some interesting properties of GFDM. In particular, our derivation seamlessly leads to an implementation of GFDM transmitter which has significantly lower complexity than what has been reported so far. Our derivation also facilitates a trivial understanding of how GFDM (similar to OFDM) can be applied in MIMO channels.

  20. Gd-DTPA-enhanced dynamic MR imaging of the kidney

    International Nuclear Information System (INIS)

    Choyke, P.L.; Frank, J.A.; Carvlin, M.J.; Austin, H.; Girton, M.J.; Inscoe, S.; Black, J.

    1988-01-01

    Dynamic Gd-DTPA-enhanced MR imaging potentially can provide both anatomic and physiologic information about the kidneys. The authors performed 42 animal imaging studies with 1.5-T MR imaging after a bolus of Gd-DTPA (0.1 mmol/kg) was given. A reproducible pattern of enhancement was observed that could be divided into three phases. In phase I a cortical blush was seen, representing intravascular contrast. Phase II represented the tubular concentration of Gd-DTPA and was depicted as a centrally migrating band that reversed direction in the inner medulla. Phase III was a gradual darkening of the inner medulla caused by concentration in the collecting ducts. This pattern was predictably altered by hydration status. The patterns observed reflected alterations in concentration of Gd-DTPA occurring in the renal tubules and collecting ducts. Gd-DTPA-enhanced renal MR imaging is promising as a renal imaging technique

  1. Estimation of glomerular filtration rate by 99mTc-DTPA dynamic renography

    International Nuclear Information System (INIS)

    Qu Wanying

    1989-01-01

    Estimation of glomerular filtration rate (GFR) by 99m Tc-DTPA dynamic renography was performed in 397 adult patients. The entire study requires only 20 minutes but obtained simultaneously the renal blood flow, renogram, renal morphology study and GFR. The GFR was calculated according to Gate's formula. Creatinine clearance values were also determined compared with GFR in 18 of the patients. The author found they correlated well each other (r = 0.93). Normal data of 14 parameters were derived from the blood flow curve. The normal value of GFR was 112.11 +- 19.05 ml/min and no significant difference in GFR of both kidney was revealed. In patients of urinary stones, essential hypertension, chronic glomerulonephritis and chronic pyelonephritis etc., there were significant lowered GFR denoted. The results showed that the estimation of GFR by 99m Tc-DTPA dynamic renography was reliable, safe and conventient method, and suitable to replace creatinine in clinical study

  2. Phantom and animal studies of a new hepatobiliary agent for MR imaging: comparison of Gd-DTPA-DeA with Gd-EOB-DTPA.

    Science.gov (United States)

    Yoshikawa, Kohki; Inoue, Yusuke; Akahane, Masaaki; Shimada, Morio; Itoh, Sayaka; Seno, Atsushi; Hayashi, Sanshin

    2003-08-01

    To investigate the characteristics of Gd-DTPA-DeA as a hepatobiliary contrast agent for MR imaging in comparison with those of Gd-EOB-DTPA. We undertook phantom experiments to assess T1 relaxivity for Gd-DTPA-DeA, Gd-EOB-DTPA, and Gd-DTPA in human plasma. For Gd-DTPA-DeA and Gd-EOB-DTPA, we evaluated the contrast effect in rats using an SPGR sequence. The contrast ratios of liver and abdominal aorta were measured up to 21 minutes after intravenous administration of the agents. Visualization of the bile duct and renal pelvis was also assessed. In human plasma, T1 relaxivity was similar for Gd-DTPA-DeA and Gd-EOB-DTPA, and higher than those for Gd-DTPA. Whereas the contrast ratio of liver peaked about five minutes after the injection of Gd-EOB-DTPA and was followed by a subsequent decline, a continuous rise was shown for Gd-DTPA-DeA, resulting in a larger maximal contrast effect. Contrast ratios of the abdominal aorta were larger for Gd-DTPA-DeA. Biliary excretion was observed for both agents but occurred earlier with Gd-EOB-DTPA. While renal excretion was shown for all rats three minutes after the injection of Gd-EOB-DTPA, it was not observed for Gd-DTPA-DeA. Gd-DTPA-DeA may be used as a hepatobiliary contrast agent and shows different pharmacokinetics from Gd-EOB-DTPA. Copyright 2003 Wiley-Liss, Inc.

  3. Determination of the mean transit time for the transport of aerosolized 99mTc-DTPA across the pulmonary epithelial membrane. A plasma sample method

    DEFF Research Database (Denmark)

    Groth, Sofie; Lassen, N A; Rossing, Niels Nygaard

    1988-01-01

    During the last decade it has been customary to estimate pulmonary epithelial permeability (P-P) as the pulmonary clearance of inhaled nebulized 99mTc-DTPA from a time-activity (t-a) curve registered externally by monitoring over the chest. The t-a curve, however, is not defined by the degree of P......-P alone but also by factors such as the deposition of the 99mTc-DTPA in the lungs. To avoid these problems a plasma sample method was derived. It describes P-P by the mean transit time (t) for the transport of 99mTc-DTPA across the pulmonary epithelial membrane, t(L). The calculation of t(L) involves two...... steps. Following the inhalation of Tc-DTPA the plasma t-a curve is defined and used to calculate t for the transport for 99mTc-DTPA across the pulmonary epithelial membrane, through the ECV and until elimination by the kidneys, t(L+ECV). Subsequently, 99mTc-DTPA is injected as a bolus i.v. and the new t...

  4. Efficacy of liver parenchymal enhancement and liver volume to standard liver volume ratio on Gd-EOB-DTPA-enhanced MRI for estimation of liver function

    Energy Technology Data Exchange (ETDEWEB)

    Yoneyama, Tomohide; Fukukura, Yoshihiko; Kamimura, Kiyohisa; Takumi, Koji; Umanodan, Aya; Nakajo, Masayuki [Kagoshima University Graduate School of Medical and Dental Sciences, Department of Radiology, Kagoshima City (Japan); Ueno, Shinichi [Kagoshima University Graduate School of Medical and Dental Sciences, Department of Surgical Oncology and Digestive Surgery, Kagoshima City (Japan)

    2014-04-15

    We aimed to develop and assess the efficacy of a liver function index that combines liver enhancement and liver volume to standard liver volume (LV/SLV) ratio on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI. In all, 111 patients underwent a Gd-EOB-DTPA-enhanced MRI, including T1 mapping, before and 20 min after Gd-EOB-DTPA administration. We calculated the following Gd-EOB-DTPA-enhanced MRI-based liver function indices: relative enhancement of the liver, corrected enhancement of the liver-to-spleen ratio, LSC{sub N}20, increase rate of the liver-to-muscle ratio, reduction rate of T1 relaxation time of the liver, ΔR1 of the liver and K{sub Hep}; the indices were multiplied by the LV/SLV ratio. We calculated the correlations between an indocyanine green (ICG) clearance and the Gd-EOB-DTPA-enhanced MRI-based liver function indices multiplied by the LV/SLV ratio, by using Pearson correlation analysis. There were significant correlations between all Gd-EOB-DTPA-enhanced MRI-based liver function indices and ICG clearance (r = -0.354 to -0.574, P < 0.001). All Gd-EOB-DTPA-enhanced MRI-based liver function indices multiplied by the LV/SLV ratio (r = -0.394 to -0.700, P < 0.001) were more strongly correlated with the ICG clearance than those without multiplication by the LV/SLV ratio. Gd-EOB-DTPA-enhanced MRI-based liver function indices that combine liver enhancement and the LV/SLV ratio may more reliably estimate liver function. (orig.)

  5. Stabilised 111In-labelled DTPA- and DOTA-conjugated neurotensin analogues for imaging and therapy of exocrine pancreatic cancer

    International Nuclear Information System (INIS)

    Visser, M. de; Krenning, E.P.; Jong, M. de; Janssen, P.J.J.M.; Srinivasan, A.; Reubi, J.C.; Waser, B.; Erion, J.L.; Schmidt, M.A.

    2003-01-01

    Neurotensin (NT) receptors are overexpressed in exocrine pancreatic cancer and Ewing's sarcoma. The potential utility of native NT in cancer diagnosis and therapy is, however, limited by its rapid degradation in vivo. Therefore, NT analogues were synthesised with modified lysine and arginine derivatives to enhance stability and coupled either to DTPA, to enable high specific activity labelling with indium-111 for imaging, or to DOTA, to enable high specific activity labelling with β-emitting radionuclides, such as lutetium-177 and yttrium-90. Based on serum stability (4 h incubation at 37 C in human serum) and receptor binding affinity, the five most promising analogues were selected and further evaluated in in vitro internalisation studies in human colorectal adenocarcinoma HT29 cells, which overexpress NT receptors. All five NT analogues bound with high affinity to NT receptors on human exocrine pancreatic tumour sections. The analogues could be labelled with 111 In to a high specific activity. The 111 In-labelled compounds were found to be very stable in serum. Incubation of HT29 cells with the 111 In-labelled analogues at 37 C showed rapid receptor-mediated uptake and internalisation. The most promising analogue, peptide 2530 [DTPA-(Pip)Gly-Pro-(PipAm)Gly-Arg-Pro-Tyr-tBuGly-Leu-OH] was further tested in vivo in a biodistribution study using HT29 tumour-bearing nude mice. The results of this study showed low percentages of injected dose per gram tissue of this 111 In-labelled 2530 analogue in receptor-negative organs like blood, spleen, pancreas, liver, muscle and femur. Good uptake was found in the receptor-positive HT29 tumour and high uptake was present in the kidneys. Co-injection of excess unlabelled NT significantly reduced tumour uptake, showing that tumour uptake is a receptor-mediated process. With their enhanced stability, maintained high receptor affinity and rapid receptor-mediated internalisation, the 111 In-labelled DTPA- and DOTA-conjugated NT

  6. Trial of MR cholangiopancreatography combined with Gd-DTPA

    Energy Technology Data Exchange (ETDEWEB)

    Ikeda, Koshi; Ha-Kawa, S.K.; Kurokawa, Hiroaki; Nakano, Yoshihisa; Tanaka, Yoshimasa [Kansai Medical Univ., Moriguchi, Osaka (Japan); Asakura, Tamaki; Maeda, Toshihiko; Ohshima, Taichi

    1997-08-01

    Gd-DTPA can be used as a negative contrast agent on T2-weighted images because of T2 shortening effect. Fast asymmetric spin echo (FASE) sequences were used on magnetic resonance cholangiopancreatography (MRCP). Precontrast images showed high signal intensity in choledochalpancreatic venous plexus, which aggravated visualization of the bile duct and pancreatic duct. Intravenous administration of Gd-DTPA reduced signal intensity in pericholedochal or peripancreatic small veins, and improved image quality of MRCP. (author)

  7. Measurement of glomerular filtration rate in connection with renography with 99mTc-DTPA

    International Nuclear Information System (INIS)

    Cappelen, T.; Skretting, A.; Winderen, M.; Aas, M.

    1999-01-01

    Glomerular filtration rate (GFR) was measured in two groups of cancer patients. In 20 patients, glomerular filtration rate was measured simultaneously with 51 Cr-EDTA, 99m Tc-DTPA and the X-ray contrast agent iohexol as markers, and with a complete set of eight blood samples during 24 hours. In a second group of 120 patients, the authors used 99m TC-DTPA only and tested various simplified methods, based on one or two blood samples. Glomerular filtration rate was also calculated from serum creatinine. There was excellent agreement between the values measured with the three markers and in the same group of patients very good agreement with the results of simplified methods. The larger study carried out with 99m Tc-DTPA on the second group of patients confirmed a very good agreement between methods based on the slope of the plasma curve and a method based on one blood sample only. The correlation was worse between the values obtained by any of the radionuclide methods and those calculated from serum creatinine. The latter method should therefore not be used for determination of renal function

  8. Preparation of 177Lu-DTPA-BIS-BIOTIN and biodistribution evaluation in normal mice

    International Nuclear Information System (INIS)

    Deng Xinrong; Luo Zhifu; Du Jin

    2010-01-01

    The labeling method for 177 Lu-DTPA-BIS-BIOTIN was established, and the biodistribution of 177 Lu-DTPA-BIS-BIOTIN in normal mice was carried out as well. Under the optimal experimental condition (DTPA-BIS-BIOTIN 25 μg, pH=4.5 reacting at 80 degree C for 20 min), the labeling yield of 177 Lu-DTPA-BIS-BIOTIN is more than 99.0%. 177 Lu-DTPA-BIS-BIOTIN shows pretty good in vitro stability. The biodistribution of 177 Lu-DTPA-BIS-BIOTIN in normal mice shows a rapid blood clearance. The uptake of 177 Lu-DTPA-BIS-BIOTIN is mainly accumulated in liver, spleen and kidney. 177 Lu-DTPA-BIS-BIOTIN is excreted by kidney. The results provide the basis for further study on 177 Lu-DTPA-BIS-BIOTIN used in pretargeted radioimage and radiotherapy of cancer. (authors)

  9. Toward an optimal DTPA therapy for decorporation of actinides: time-dose relationships for plutonium in the dog. I

    International Nuclear Information System (INIS)

    Guilmette, R.A.; Moretti, E.S.; Lindenbaum, A.

    1979-01-01

    Studies have been performed to provide data needed for the development of an optimal protocol for the clinical application of DTPA (diethylenetriaminepentaacetic acid) for treatment of humans accidentally exposed to certain actinide radioelements such as plutonium (Pu). Groups of two or three beagle dogs previously injected intravenously with 0.3 μCi/kg monomeric 239 Pu-citrate were treated twice weekly, beginning at 6 hr, with either 0.18 or 0.036 mmol/kg Na 3 CaDTPA or, beginning at 6 or 89 days, with 0.18 mmole/kg DTPA. The animals were sacrificed 12 weeks (in one case, 4 weeks) after the beginning of therapy, and selected soft tissue and bone samples were analyzed radiochemically for Pu content. DTPA treatment initiated at 6 hr after Pu injection was superior to treatment begun at 6 to 89 days; much of the additional benefit of the 6-hr treatment was derived from increased removal of circulating Pu, hence prevention of deposition. When treatment was begun at 6 hr (the latter being the currently accepted blinical dose). When the initiation of therapy was delayed for 6 days, a 3-month regime of twice-weekly treatment at 0.18 mmole/kg was superior to similar treatment for 1 month

  10. Actinides exposure: review of Ca-DTPA injections inside Cea-Cogema plants

    International Nuclear Information System (INIS)

    Grappin, L.; Berard, P.; Beau, P.; Carbone, L.; Castagnet, X.; Courtay, C.; Le Goff, J.P.; Menetrier, F.; Neron, M.; Piechowski, J.

    2006-01-01

    Ca-DTPA has been used for medical treatment of plutonium and americium contaminations in the CEA and COGEMA plants from 1970 to 2003. This report is a survey of the injections administered of Ca-DTPA as a chelating molecule. This report will be a part of the AMM process for Ca-DTPA by intravenous administration submitted by the Central Pharmacy of the french Army. Out of 1158 injections administered to 469 persons, 548 events of possible or confirmed contaminations were reported. These employees were followed by occupational physicians according to the current regulations. The first part of the report is a synthesis of the most recent findings. Due to its short biological period and its limited action in the blood, Ca-DTPA does not chelate with plutonium and americium as soon as these elements are deposited in the target organs. It justifies an early treatment, even in cases of suspected contamination followed by additional injections if necessary. The second part presents data concerning these 1158 injections (way of contamination, posology, adverse effects...). These incidents took place at work, were most often minor, not requiring follow-up treatment. A study concerning the effectiveness of the product was done on a group of people having received 5 or more injections. These results were compared with effectiveness estimated from theoretical basis. Posologies and therapeutic schemes were proposed based on these observations. Additional studies are needed to confirm these findings. This document is the first synthesis in this field. It is the result of a collective work having mobilized the occupational medicine departments, the laboratories of CEA and COGEMA and a working group CEA-COGEMA-SPRA. (authors)

  11. Effect of raised thoracic pressure and volume on 99mTc-DTPA clearance in humans

    Energy Technology Data Exchange (ETDEWEB)

    Nolop, K.B.; Maxwell, D.L.; Royston, D.; Hughes, J.M.

    1986-05-01

    Although positive airway pressure is often used to treat acute pulmonary edema, the effects on epithelial solute flux are not well known. We measured independently the effect of 1) positive pressure and 2) voluntary hyperinflation on the clearance of inhaled technetium-99m-labeled diethylenetriaminepentaacetic acid (/sup 99m/Tc-DTPA) in six nonsmokers and six smokers. Lung volumes were monitored by inductance plethysmography. Each subject was studied in four situations: 1) low end-expiratory volume (LO-), 2) low volume plus 9 cmH2O continuous positive airway pressure (LO+), 3) high end-expiratory volume (HI-), and 4) high volume plus continuous positive airway pressure (HI+). The clearance half time of 99mTc-DTPA for the nonsmokers decreased from 64.8 +/- 7.0 min (mean +/- SE) at LO- to 23.2 +/- 5.3 min at HI- (P less than 0.05). Positive pressure had no synergistic effect. The mean clearance half time for the smokers was faster than nonsmokers at base line but unaffected by similar changes in thoracic volume and pressure. We conclude that, in nonsmokers, positive airway pressure increases /sup 99m/Tc-DTPA clearance primarily through an increase in lung volume and that smokers are immune to these effects.

  12. Hemophilic arthropathy of the knee joint: static and dynamic Gd-DTPA - enhanced MRI

    Energy Technology Data Exchange (ETDEWEB)

    Naegele, M. [Dept. of Radiology, Univ. Bonn (Germany); Bruening, R. [Dept. of Radiology, Univ. Muenchen (Germany); Kunze, V. [Dept. of Radiology, Univ. Bonn (Germany); Eickhoff, H. [Dept. of Orthopedic Surgery, Troisdorf (Germany); Koch, W. [Dept. of Orthopedic Surgery, Troisdorf (Germany); Reiser, M. [Dept. of Radiology, Univ. Muenchen (Germany)

    1995-12-31

    A total of 17 patients with hemophilic arthropathy of the knee joint were studied with static and dynamic MRI before and after an IV bolus injection of Gadolinium-DTPA (Gd-DTPA; 0.1 mmol/kg body weight). The T1-weighted spin-echo (SE) and gradient-echo (fast-field echo [FFE]) sequences were applied. The FFE sequences of eight consecutive scans carried out over a time interval of 160 s were used in order to determine the time to signal intensity (SI) curves of the synovial proliferations surrounding soft tissue, bone marrow, and joint effusion. After the administration of a contrast agent, synovial proliferations exhibited an increase on FFE and SE images of 47.7% (SD {+-} 14.3%) and 37.4% (SD {+-} 11.2%), respectively, whereas muscle and fatty tissue, tendons, bone marrow, and joint effusion revealed only a minor increase in SI. The gradient of SI (ratio SI/time) of pannus was 39.6%/min (SD {+-} 7.7%/min) and differed significantly (P < 0.001) from that of bone marrow, fatty tissue, muscle tissue, tendons, and joint effusion (P < 0.05). In contrast to synovial proliferations in rheumatoid arthritis, no differentiation between various pannus vascularities based on the degree of enhancement was possible. The Gd-DTPA-enhanced MRI studies delineate and quantify the synovial proliferations in hemophilic arthropathy. Dynamic studies in hemophilic arthropathy do not provide qualitative assessment of the inflammatory process. (orig.)

  13. New insights into formation of trivalent actinides complexes with DTPA.

    Science.gov (United States)

    Leguay, Sébastien; Vercouter, Thomas; Topin, Sylvain; Aupiais, Jean; Guillaumont, Dominique; Miguirditchian, Manuel; Moisy, Philippe; Le Naour, Claire

    2012-12-03

    Complexation of trivalent actinides with DTPA (diethylenetriamine pentaacetic acid) was studied as a function of pcH and temperature in (Na,H)Cl medium of 0.1 M ionic strength. Formation constants of both complexes AnHDTPA(-) and AnDTPA(2-) (where An stands for Am, Cm, and Cf) were determined by TRLFS, CE-ICP-MS, spectrophotometry, and solvent extraction. The values of formation constants obtained from the different techniques are coherent and consistent with reinterpreted literature data, showing a higher stability of Cf complexes than Am and Cm complexes. The effect of temperature indicates that formation constants of protonated and nonprotonated complexes are exothermic with a high positive entropic contribution. DFT calculations were also performed on the An/DTPA system. Geometry optimizations were conducted on AnDTPA(2-) and AnHDTPA(-) considering all possible protonation sites. For both complexes, one and two water molecules in the first coordination sphere of curium were also considered. DFT calculations indicate that the lowest energy structures correspond to protonation on oxygen that is not involved in An-DTPA bonds and that the structures with two water molecules are not stable.

  14. Does the application of gadolinium-DTPA have an impact on magnetic resonance phase contrast velocity measurements? Results from an in vitro study

    International Nuclear Information System (INIS)

    Heverhagen, J.T.; Hoppe, M.; Klose, K.-J.; Wagner, H.-J.

    2002-01-01

    Introduction/objective: To evaluate the potential influence of various concentrations of gadolinium (Gd)-DTPA on magnetic resonance phase contrast (MR PC) velocimetry. Material and methods: Imaging was done with a 1.0 T scanner using a standard Flash 2D sequence and a circular polarized extremity coil. In a validated flow phantom with a defined 75% area stenosis different concentrations of Gd-DTPA, diluted in a 10:1 water-yogurt mixture, MR PC measurements were correlated with a Doppler guide wire as gold standard. Results: MR PC measurements correlated well with the Doppler derived data (r=0.99; P 0.05; Student's t-test) flow measurement changes were noted (maximum pre-stenotic velocity: 21.3±1.3 cm/s; maximum intra-stenotic velocity: 84.0±3.6 cm/s). However, delineation of the perfused lumen was enhanced after the application of Gd-DTPA. Discussions and conclusion: The application of Gd-DTPA does not affect MR PC velocimetry. However, the application of contrast media allowed a more accurate vessel segmentation. MR PC measurements can be reliably carried out after application of Gd-DTPA

  15. Diagnostic value of Gd-DTPA in mediastinal masses

    International Nuclear Information System (INIS)

    Hahn, D.; Naegele, M.; Seelos, K.; Lissner, J.A.

    1987-01-01

    Thirty-three patients with different mediastinal masses were examined with a 1.0-T Magnetom using Gd-DTPA. In all patients short spin echo sequences without and with Gd-DTPA as well as fast imaging sequences with reduced echo delay times or different flip angles in gradient echoes were compared. The relative enhancement rate in tumor tissue, fat, muscle and bone marrow was evaluate by signal-intensity measurement before and after application of contrast medium. The uptake of contrast medium in benign masses and inflammatory diseases was significantly lower than in malignant masses. The good enhancement of mediastinal tumors allowed a better differentiation of the inner structure of the tumor. A better differential diagnosis of malignant tumors could not be done by measuring the signal intensity enhancement rate because of overlapping values. Gd-DTPA-enhanced MR imaging may, however, be helpful in follow-up studies in patients with malignant lymphomas

  16. Preparation of Indium Pentetate Complex (111 In-DTPA)

    International Nuclear Information System (INIS)

    Shahhosseini, S.; Farshidfar, G.R.; Najafi, R.

    2000-01-01

    There is no organometallic compound of Indium know to exist naturally in the human body. However, a number of compounds prepared with 111 In have been evaluated for localization studies. The useful radioactive decay characteristics and the suitable chemical properties of the metal ion have drawn attention of many investigators resulting in the preparation of numerous 111 In labeled compounds for potential medical applications. One of them is 111 In-DTPA complex that is used for cerebral spinal fluid studies. In the present study, DTPA has been chelated with 111 In by employing various methods and then tested for its stability in vitro during storage and in human plasma. Three methods for the preparation of 11 1In-DTPA were used. In every method, labeling efficiency and radiochemical purity were determined by chromatography systems

  17. Comparison of oral iodine-131-cellulose and indium-111-DTPA as tracers for colon transit scintigraphy: Analysis by colon activity profiles

    International Nuclear Information System (INIS)

    Smart, R.C.; McLean, R.G.; Gaston-Parry, D.; Barbagallo, S.; Bruck, C.E.; King, D.W.; Lubowski, D.Z.; Talley, N.A.

    1991-01-01

    In 11 normal subjects and 11 patients with a clinical diagnosis of constipation, oral 131I-cellulose and 111In-DTPA were compared simultaneously as tracers for radionuclide colon transit scintigraphy. Visual assessment of the images revealed no differences between tracers. Quantitation was performed using total and segmental percent retention and the derived value of clearance half-time. In addition, profiles of the activity distribution along the length of the colon were generated and the mean position of the activity in the colon calculated. For all indices, the results were similar in both normal subjects and constipated patients when comparing tracers, although marked differences were present between normal subjects and constipated patients for each tracer. Indium-111-DTPA was easy to administer and dosimetry was more acceptable than for 131I-cellulose, especially in constipated patients. It is concluded that 111In-DTPA is the preferred tracer for oral colon transit scintigraphy

  18. Synthesis of Tumor-avid Photosensitizer-Gd(III)DTPA conjugates: impact of the number of gadolinium units in T1/T2 relaxivity, intracellular localization, and photosensitizing efficacy.

    Science.gov (United States)

    Goswami, Lalit N; White, William H; Spernyak, Joseph A; Ethirajan, Manivannan; Chen, Yihui; Missert, Joseph R; Morgan, Janet; Mazurchuk, Richard; Pandey, Ravindra K

    2010-05-19

    To develop novel bifunctional agents for tumor imaging (MR) and photodynamic therapy (PDT), certain tumor-avid photosensitizers derived from chlorophyll-a were conjugated with variable number of Gd(III)aminobenzyl DTPA moieties. All the conjugates containing three or six gadolinium units showed significant T(1) and T(2) relaxivities. However, as a bifunctional agent, the 3-(1'-hexyloxyethyl)pyropheophorbide-a (HPPH) containing 3Gd(III) aminophenyl DTPA was most promising with possible applications in tumor-imaging and PDT. Compared to HPPH, the corresponding 3- and 6Gd(III)aminobenzyl DTPA conjugates exhibited similar electronic absorption characteristics with a slightly decreased intensity of the absorption band at 660 nm. However, compared to HPPH, the excitation of the broad "Soret" band (near 400 nm) of the corresponding 3Gd(III)aminobenzyl-DTPA analogues showed a significant decrease in the fluorescence intensity at 667 nm.

  19. Decorporation of 241Am in beagles by DTPA

    International Nuclear Information System (INIS)

    Lloyd, R.D.; McFarland, S.S.; Taylor, G.N.; Williams, J.L.; Mays, C.W.

    1975-01-01

    Chelation treatments using daily subcutaneous injections of ZnNa 3 -DTPA were begun 2 wk after the intravenous administration of 0.3 μCi/kg 241 Am citrate to six female beagles averaging 505 days of age. Retention of americium in the liver and in non-liver tissue (mainly skeleton) was followed serially in the living dogs by a combination of total-body and partial-body counting. During the first 13 mo of DTPA therapy, the removal of 241 Am from two dogs given one DTPA injection each day of 0.027 or 0.034 mmole/kg was similar to the fraction removed from two other dogs given a similar total of 0.035 or 0.037 mmole/kg/day in five fractionated injections each day. Increasing the daily amount of DTPA to 0.36 and 5.0 mmole/kg/day in the two remaining dogs only slightly increased the removal of 241 Am. At the beginning of chelation therapy, all six dogs averaged 43 percent of the injected 241 Am in the liver and 46 percent in nonliver tissue. 241 Am retention in liver at 2 mo of therapy was about 2 percent of pretreatment liver retention, decreased to roughly 1 percent of pretreatment retention by 5 mo of DTPA administration, and was undetectable at 13 months. Nonliver retention at 2 mo was 53 percent of pretreatment retention in nonliver tissue, at 5 mo averaged about 40 percent, and had decreased to 27 percent of pretreatment values by 13 mo of chelation therapy. In contrast, for beagles of our colony not treated with DTPA, 241 Am in the liver and in nonliver tissue exhibited a biological half-time in the order of 10 yr. (U.S.)

  20. Value of Gd-EOB-DTPA-enhanced MRI in diagnosis of hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    SUN Yu

    2018-01-01

    Full Text Available Objective To investigate the value of Gd-EOB-DTPA-enhanced MRI in the diagnosis of hepatocellular carcinoma (HCC. Methods A total of 40 patients with liver cirrhosis or suspected HCC who visited General Hospital of Shenyang Military Area Command from October 2016 to April 2017 were enrolled, and the data on three dynamic phases of Gd-EOB-DTPA-enhanced MRI (arterial phase, portal venous phase, and delayed phase, hepatobiliary phase (delayed for 20 minutes, and diffusion-weighted imaging (DWI (b=50,400, and 1000 s/mm2 were collected. Two radiologists made a diagnosis and gave diagnostic confidence scores based on the presence or absence of hepatobiliary phase images. Postoperative pathology or clinical diagnosis was used as the criteria for assessing the diagnostic accuracy of HCC. The t-test was used for comparison of continuous data, and the chi-square test was used for comparison of categorical data. Results A total of 42 HCC lesions and 37 cirrhotic nodules were detected. There were significant differences between HCC lesions and cirrhotic nodules in signal intensity on hepatobiliary phase and DWI (χ2=64.503 and 67.855, both P<0.001,as well as the apparent diffusion coefficient when the b-values of DWI were 400 s/mm2 and 1000 s/mm2 (t=62.75 and 75.36, both P<0.001. There was a significant difference in diagnostic confidence score given by the radiologists between the images of three dynamic phases of Gd-EOB-DTPA-enhanced MRI and those of four dynamic phases (including hepatobiliary phase (3.260±0.521 vs 4.620±0.661, t=10.67, P<0.001. With postoperative pathology and clinical diagnosis as criteria, the images of three dynamic phases of Gd-EOB-DTPA-enhanced MRI had a significantly higher diagnostic accuracy for HCC than those of four dynamic phases (including hepatobiliary phase [76.19% (32/42 vs 95.24% (40/42, χ2=6.222, P=0.013]. Conclusion Gd-EOB-DTPA-enhanced MRI may improve diagnostic accuracy and confidence for HCC and has

  1. Easy and efficient (111)Indium labeling of long-term stored DTPA conjugated protein

    DEFF Research Database (Denmark)

    Nalla, Amarnadh; Buch, Inge; Hesse, Birger

    2011-01-01

    The labelling efficiency of long-term stored DTPA-conjugates has not been reported previously even though DTPA has been in extensive use as metal chelator in the development of radiopharmaceuticals and contrast agents. DTPA is often used as a bifunctional chelating agent conjugated to tumor...

  2. Easy and Efficient 111Indium Labeling of Long-Term Stored DTPA Conjugated Protein

    DEFF Research Database (Denmark)

    Nalla, Amarnadh; Buch, Inge; Hesse, Birger

    2011-01-01

    The labelling efficiency of long-term stored DTPA-conjugates has not been reported previously even though DTPA has been in extensive use as metal chelator in the development of radiopharmaceuticals and contrast agents. DTPA is often used as a bifunctional chelating agent conjugated to tumor...

  3. Synthesis of Pharmacological Heterocyclic Derivatives Based Surfactants.

    Science.gov (United States)

    El-Sayed, Refat; Fadda, Ahmed A

    2016-01-01

    Synthesis of chromenopyrimidine derivatives and the related fused system carried out by the reaction of chromene derivative 1 with various reagents under suitable reaction conditions. Condensation of stearoyl chloride with these heterocycles, then, propoxylated the products using propylene oxide to produce surface active agents having a twofold capacity as surface and antimicrobial dynamic specialists which may be served in the production of medications, pesticides, beautifying agents or may be utilized as an antimicrobial. Some of the surface properties and antimicrobial activity were resolved.

  4. Comparative microvascular exchange kinetics of [{sup 77}Br]bromide and {sup 99m}Tc-DTPA in humans

    Energy Technology Data Exchange (ETDEWEB)

    Cousins, Claire [Department of Clinical Radiology, Addenbrooke' s Hospital, Cambridge (United Kingdom); Skehan, Stephen J.; Rolph, Susan M.; Flaxman, Mary E.; Ballinger, James R.; Bird, Nicholas J.; Barber, Robert W.; Peters, Michael A. [Department of Nuclear Medicine, Addenbrooke' s Hospital, Cambridge (United Kingdom)

    2002-05-01

    The plasma clearance curves of small hydrophilic solutes comprise three exponentials, consistent with a three-compartmental distribution model. A previous comparison between inulin and diethylene triamine penta-acetic acid (DTPA) suggested that these three compartments are in series, the first being plasma and the second and third representing compartments within the extravascular space. Moreover, whilst the total distribution volumes of these two indicators were similar, the volume of the second compartment was higher for DTPA. The purpose of the current study was to investigate whether a solute smaller than DTPA, namely bromide, fits the hypothesis that the second space volume is an inverse function of the size of the solute. Two groups of subjects were studied: group A comprised eight patients undergoing routine diagnostic arteriography and group B, eight patients referred for routine measurement of glomerular filtration rate plus two normal volunteers. {sup 99m}Tc-DTPA and sodium [{sup 77}Br]bromide were intravenously administered simultaneously. In group A, frequent arterial samples were obtained up to 40 min after injection, and antecubital venous samples 30 s after each arterial sample. In group B, frequent venous samples were obtained up to 280 min after injection. Volume measurements based on bromide were corrected for erythrocyte bromide accumulation. In both subject groups, the normalised venous concentration ratio of bromide to DTPA, corrected for red cell bromide uptake, was significantly less than unity in the earliest blood samples, being 0.56 (SD 0.08) at 1 min, consistent with faster diffusion of bromide from plasma to interstitial fluid. Furthermore, the extraction fraction of bromide from plasma to interstitial fluid in the forearm was about 0.6, higher than that of DTPA (about 0.5) in spite of red cell bromide accumulation which equilibrated with plasma bromide within 20 s and resulted in a red cell to plasma concentration ratio of 0.51 (0

  5. Fetal injury induced by Ca-DTPA in dogs

    International Nuclear Information System (INIS)

    Taylor, G.N.; Mays, C.W.

    1978-01-01

    The chelating agent Ca-DTPA, used to remove plutonium from the body, has produced fetal deaths and deformities in mice and rats. Damage is caused by depletion of essential trace elements, particularly zinc and manganese. It is suggested that a relationship may exist between the daily amount of Ca-DTPA,per kg body weight needed,to produce fetal toxicity and the daily intake of dietary zinc per kg body weight, and that this relationship could be used to predict fetal toxicity thresholds in various species. Results of a study on beagles are presented. Ca-DTPA treatment at the dose levels used in human therapy did not produce any symptoms in the pregnant dams but the fetuses showed depressed birth weight, abnormal hair colour due to pigmentary deficiency, brain damage and neutropenia. Extrapolation from dogs to humans predicts a toxic fetal dose less that one sixth of the daily dosage presently used for an adult woman, and emphasizes the hazards of Ca-DTPA therapy during pregnancy. (author)

  6. Quality control for 12 batch of DTPA-Sn

    International Nuclear Information System (INIS)

    Isaac, M.; Gamboa, R.; Leyva, R.; Hernandez, I.; Turino, D.

    1994-01-01

    The quality control is carry out at 12 batch of DTPA-Sn for labeling with 99 m Tc. The instrumental methods of analysis and control charts were discussed in order to find a warranty time for the product. (author). 2 refs, 3 figs, 1 tab

  7. Gadolinium-DTPA enhanced MRI in myocardial infarction

    International Nuclear Information System (INIS)

    Dijkman, P.R.M. van.

    1991-01-01

    This thesis focuses on one aspect of cardiac magnetic resonance imaging (MRI) for noninvasive screening of ischemic heart disease: the identification and quantification of acutely infarcted myocardium using gadolineum-diethylene triamine pentaacetic acid (Gd-DTPA) enhanced T1-weighted MRI in a clinical and experimental setting. (author). 296 refs.; 34 figs.; 4 tabs

  8. Influence of soil type differences on the distribution of DTPA ...

    African Journals Online (AJOL)

    This study determined the effects of the application of industrial liquid waste from a textile factory on the distribution of DTPA extractable metals in a Pelli-Eutric Vertisol and an Eutric Fluvisol at Akaki in Ethiopia, classified according to the FAO-UNESCO Soil Classification System. The Fluvisol is slightly basic on the surface ...

  9. influence of soil type differences on the distribution of dtpa

    African Journals Online (AJOL)

    Preferred Customer

    OF DTPA EXTRACTABLE HEAVY METALS IN SOILS ... Fluvisol is slightly basic on the surface and has sandy clay to clay loam texture, while the Vertisol is ..... The above signifies that Cu exceeds normally expected levels. Cu in contaminated soils relates well with the water analysis result. Fe, and Mn concentrations have ...

  10. Induction of Bordetella pertussis-specific immune memory by DTPa vaccines.

    Science.gov (United States)

    Morel, Sandra; Denoël, Philippe; Godfroid, Fabrice; Cortvrindt, Caroline; Vanderheyde, Nathalie; Poolman, Jan

    2011-04-18

    Several vaccines are available against pertussis, differing by the number of Bordetella pertussis antigens that they contain as well as their formulation. The GlaxoSmithKline Biologicals (GSK Bio) tricomponent DTPa vaccine (DTPa3, Infanrix™), and the Sanofi-Pasteur (SP) five-component formulation (DTPa5, Pediacel™) were shown to have comparable short-term efficacy in clinical trials. However, potential differences in long-term protection were recently suggested, which might reflect the elicitation of different specific immune memory by the two vaccines. Therefore, the purpose of the present study was to investigate in mice the immune responses against B. pertussis, and particularly the establishment of specific B cell memory after immunization with DTPa3 and DTPa5 vaccines. Whereas intranasal challenge experiments showed similar protection with both vaccines, DTPa3 induced higher antibody levels to FHA and PRN than DTPa5. Further, the frequency of memory B cells was investigated by B cell ELISPOT. Higher frequencies of PT- and PRN-specific memory B cells were evidenced after vaccination with DTPa3, compared with DTPa5. Although the origin of such difference is unclear, the use of two different adjuvants (aluminum phosphate versus hydroxide) is proposed as a possible explanation. In conclusion, this study proposes that the induction of higher levels of B. pertussis antigen-specific memory B cells with DTPa3 participate to the suggested longer persistence of protection observed with this vaccine, as compared with DTPa5. Copyright © 2011 Elsevier Ltd. All rights reserved.

  11. Toxicological study on the safety of DTPA as a drug, (1)

    International Nuclear Information System (INIS)

    Fukuda, Satoshi; Iida, Haruzo

    1983-01-01

    In order to clarify the safety of Ca-DTPA and Zn-DTPA recommended to use as drugs in the therapeutic removal of incorporated radionuclides from the human body, the teratological study on these two agents was carried out in rats as one of a series of the toxicological tests. The teratological effects of DTPA were observed because the fetus is highly susceptible to any drug. The pregnant females of Wistar rat were injected subcutaneously daily on days 9-13 of gestation with 1, 6, 12, 24 and 36 H.D. (H.D. = human dose, 1 H.D. = 30μmol/kg body weight) of Ca-DTPA or Zn-DTPA, respectively. In the dams, no toxic effects were observed. In the fetuses, the decrease of the survival rate was observed in only the group injected daily with 36 H.D. of Ca-DTPA. Some cases of gross defects of fetuses: the exencephaly, microphthalmia, anophthalmia and fusion of ribs were observed in the groups injected daily with 12, 24 and 36 H.D. of Ca-DTPA. The results obtained show that Ca-DTPA should not be given to a pregnant woman. However, no toxic effects of either Ca-DTPA or Zn-DTPA observed in the dams ana of Zn-DTPA even in the fetuses indicate that these agents can be used by a radiation worker who usually is an adult man. (author)

  12. Regional respiratory clearance of aerosolized /sup 99m/Tc-DTPA: posture and smoking effects

    International Nuclear Information System (INIS)

    Dusser, D.J.; Minty, B.D.; Collignon, M.A.; Hinge, D.; Barritault, L.G.; Huchon, G.J.

    1986-01-01

    We studied 10 healthy nonsmokers and 8 healthy smokers, in both the upright and supine position, to investigate whether regional differences in respiratory clearance of technetium-99m-labeled diethylenetriamine pentaacetic acid /sup 99m/Tc-DTPA (RC-DTPA) existed and to assess the influence of posture and smoking on the regional RC-DTPA. RC-DTPA was assessed by the lung clearance rates (%/min) of aerosolized /sup 99m/Tc-DTPA (0.8 micron MMD; 2.4 GSD), using data corrected for recirculating radioactivity, in the upper (zone 1), middle (zone 2), and lower (zone 3) posterior lung fields. In nonsmokers, RC-DTPA in zone 1 was faster than in zone 2 or 3 in both the upright (P less than 0.001) and supine positions (P less than 0.0). No effect was produced by changes in posture on the regional RC-DTPA. In smokers, RC-DTPA was increased in all zones compared with the nonsmokers (P = 0.004), with a further increase in RC-DTP in zone 1 in the upright posture compared with the other regions (P less than 0.001). We conclude that in nonsmokers regional RC-DTPA is faster in zone 1 than in other zones, and this is not related to recirculation of radioactivity; posture does not modify the regional RC-DTPA of nonsmokers; smoking increases RC-DTPA in all zones and more in zone 1 in the upright posture

  13. Regional respiratory clearance of aerosolized /sup 99m/Tc-DTPA: posture and smoking effects

    Energy Technology Data Exchange (ETDEWEB)

    Dusser, D.J.; Minty, B.D.; Collignon, M.A.; Hinge, D.; Barritault, L.G.; Huchon, G.J.

    1986-06-01

    We studied 10 healthy nonsmokers and 8 healthy smokers, in both the upright and supine position, to investigate whether regional differences in respiratory clearance of technetium-99m-labeled diethylenetriamine pentaacetic acid /sup 99m/Tc-DTPA (RC-DTPA) existed and to assess the influence of posture and smoking on the regional RC-DTPA. RC-DTPA was assessed by the lung clearance rates (%/min) of aerosolized /sup 99m/Tc-DTPA (0.8 micron MMD; 2.4 GSD), using data corrected for recirculating radioactivity, in the upper (zone 1), middle (zone 2), and lower (zone 3) posterior lung fields. In nonsmokers, RC-DTPA in zone 1 was faster than in zone 2 or 3 in both the upright (P less than 0.001) and supine positions (P less than 0.0). No effect was produced by changes in posture on the regional RC-DTPA. In smokers, RC-DTPA was increased in all zones compared with the nonsmokers (P = 0.004), with a further increase in RC-DTP in zone 1 in the upright posture compared with the other regions (P less than 0.001). We conclude that in nonsmokers regional RC-DTPA is faster in zone 1 than in other zones, and this is not related to recirculation of radioactivity; posture does not modify the regional RC-DTPA of nonsmokers; smoking increases RC-DTPA in all zones and more in zone 1 in the upright posture.

  14. Photocatalytic Based Degradation Processes of Lignin Derivatives

    Directory of Open Access Journals (Sweden)

    Colin Awungacha Lekelefac

    2015-01-01

    Full Text Available Photocatalysis, belonging to the advanced oxidation processes (AOPs, is a potential new transformation technology for lignin derivatives to value added products (e.g., phenol, benzene, toluene, and xylene. Moreover, lignin represents the only viable source to produce aromatic compounds as fossil fuel alternative. This review covers recent advancement made in the photochemical transformation of industrial lignins. It starts with the photochemical reaction principle followed by results obtained by varying process parameters. In this context, influences of photocatalysts, metal ions, additives, lignin concentration, and illumination intensity and the influence of pH are presented and discussed. Furthermore, an overview is given on several used process analytical methods describing the results obtained from the degradation of lignin derivatives. Finally, a promising concept by coupling photocatalysis with a consecutive biocatalytic process was briefly reviewed.

  15. Computation of glomerular filtration rate with Tc-99m DTPA: an in-house computer program

    International Nuclear Information System (INIS)

    Gates, G.F.

    1984-01-01

    The glomerular filtration rate (GFR) can be computed from the scintigraphic determination of Tc-99m DTPA (diethylenetriaminepentaacetic acid) uptake within the kidneys. The required computations are straightforward and can easily be included in the software of various computers, including a hospital's existing data-processing system. This report present a complete operational program based on extensive experience with this method. The program is easy to use, allows for adjustments to be made for unusual clinical conditions, and produces a permanent record that can be issued as part of the final report

  16. Treatment with Ca-DTPA of internal contaminations by plutonium and americium: Recommendations for writing protocols in Cea and AREVA centers

    International Nuclear Information System (INIS)

    Grappin, L.; Legoff, J.P.; Andre, F.; Carbone, L.; Agrinier, A.L.; Courtay, C.; Aninat, M.; Amabile, J.C.; Florin, A.

    2009-01-01

    The purpose of this document is to provide physicians working in a B.N.F. (Basic Nuclear Facility) with recommendations for the drafting of Ca-DTPA treatment protocols for internal contamination by actinides. These recommendations are based on the results of injections carried out by Cea and AREVA doctors in a working group, with the collaboration of the Army Radiation Protection Service. The study focused on Ca-DTPA IV injection. Other dosage forms, routes of administration as well as adjuvant treatments are also mentioned. For cases of contaminated wounds and inhalation, indicators for treatment with Ca-DTPA, particularly its initialization, the dosage, duration, frequency of administration, the criteria for ending the treatment, then its efficiency and dosimetry gain are covered. A guide for the prescription of the radio toxicological monitoring necessary for the treatment and the dosimetric evaluation is proposed. (authors)

  17. Improved measurement of the glomerular filtration rate from Tc-99m DTPA scintigraphy in patients following nephrectomy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yong-il; Ha, Seunggyun [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Seoul National University Bundang Hospital, Department of Nuclear Medicine, Seongnam-si, Gyeonggi-do (Korea, Republic of); So, Young [Konkuk University School of Medicine, Department of Nuclear Medicine, Chungju (Korea, Republic of); Lee, Won Woo [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Seoul National University, Institute of Radiation Medicine, Medical Research Center, Seoul (Korea, Republic of); Seoul National University Bundang Hospital, Department of Nuclear Medicine, Seongnam-si, Gyeonggi-do (Korea, Republic of); Byun, Seok-Soo [Seoul National University College of Medicine, Department of Urology, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Kim, Sang Eun [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Seoul National University, Institute of Radiation Medicine, Medical Research Center, Seoul (Korea, Republic of)

    2014-02-15

    We aimed to improve Tc-99m DTPA glomerular filtration rate (GFR) scintigraphy (Gates' method) in a prospective study using Cr-51 EDTA GFR test as a gold standard. Fifty-seven Tc-99m DTPA GFR scintigrams in 45 subjects (male/female = 33:12, age = 45.9 ± 17.6 years, 14 healthy volunteers and 31 nephrectomised patients) were compared using Cr-51 EDTA GFR tests. Using the %renal uptake of Tc-99m DTPA and Cr-51 EDTA GFR, a revised equation for GFR was established through linear regression analysis. The revised equation for improved GFR was GFR(mL/min) = (%renal uptake x 11.7773) - 0.7354. Gates' original GFRs (70.1 ± 20.5 mL/min/1.73 m{sup 2}) were significantly lower than Cr-51 EDTA GFRs (97.0 ± 31.9 mL/min/1.73 m{sup 2}; P < 0.0001), but the improved GFRs (98.0 ± 26.3 mL/min/1.73 m{sup 2}) were not different from (P = 0.7360) and had a significant correlation with (r = 0.73, P < 0.0001) the Cr-51 EDTA GFRs. The revised GFR equation effectively demonstrated perioperative GFR changes in kidneys that were operated on and the contralateral kidneys at 3 and 6 months post-partial nephrectomy (n = 25). GFR measurement using Tc-99m DTPA scintigraphy could be significantly improved by a revised equation derived from the comparison with Cr-51 EDTA GFR. (orig.)

  18. Separation of americium and neodymium by selective stripping and subsequent extraction with HDEHP using DTPA-lactic acid solution in a closed loop

    International Nuclear Information System (INIS)

    Svantesson, I.; Hangstroem, I.; Persson, G.; Liljenzin, J.O.

    1979-01-01

    A method for the separation of trivalent actinides and lanthanides is proposed. The method is based on selective stripping of the actinides from 1M HDEHP into an aqueous phase containing ammonia, DTPA and lactic acid followed by subsequent extraction into a second organic phase also containing 1M HDEHP. The aqueous phase is recycled in a closed loop, thereby reducing the amounts of secondary waste. Distribution ratios for Am and Nd have been measured at varying DTPA and lactic acid concentrations and at varying pH. The distribution of ammonia was also measured. (author)

  19. Correlation of glomerular filtration rate measurement using Tc-99m DTPA with cystatin-C levels and creatinine clearance for staging of chronic kidney disease

    International Nuclear Information System (INIS)

    Elliyanti, A.; Iskandar, Azmi S.

    2007-01-01

    Full text: The presence of Chronic Kidney Disease (CKD) was established based on kidney damage presence and the level of kidney function through Glomerular filtration rate (GFR). It was also recognized that renal scintigraphy (renogram) using TC-99m DTPA (diethylenetriamine pentacetic acid) has advantages in the measurement of GFR. Recently, serum Cystatin-C is proposed as the new marker of GFR. The aim of this study is to find out the correlation of GFR, derived from renogram, with Cystatin- C levels and Creatinine Clearance (CC) in CKD. Material and Methods: A total of 30 subjects (age mean is 60.8 years, 21 males and 9 females) were enrolled in this study with diagnosis stage 2 of CKD. CKD staging was determined by Cockroft-Gault (CG) equation, taking into account the serum creatinine. Renogram was performed using a single head camera with IV administration of 5 mCi DTPA. Cystatin-C and creatinine clearance (24-hours urine samples) were include in this study. Results: The mean GFR of renogram, Cystatin-C, CC and CG are 64.96 ml/min/1.73m2 (SD 28.047), 53.37 ml/min/1.73m2 (SD 21.29), 58.09 ml/min/1.73m2 (SD 35.45), 46.00 ml/min/1.73m2 (SD 12.06) respectively. There is better correlation between renogram and Cystatin-C (r=0.585, p0.0007) compared renogram and CC (r=0.388, p=0.03) or renogram and CG (r=-0.029, p=0.87). Conclusion: Cystatin-C shows better indicator of GFR than CC and CG. Serum creatinine concentration alone should not be used to assess the level of kidney function in the staging of CKD. (author)

  20. Relationship of end-expiratory pressure, lung volume, and /sup 99m/Tc-DTPA clearance

    International Nuclear Information System (INIS)

    Cooper, J.A.; van der Zee, H.; Line, B.R.; Malik, A.B.

    1987-01-01

    We investigated the dose-response effect of positive end-expiratory pressure (PEEP) and increased lung volume on the pulmonary clearance rate of aerosolized technetium-99m-labeled diethylenetriaminepentaacetic acid (99mTc-DTPA). Clearance of lung radioactivity was expressed as percent decrease per minute. Base-line clearance was measured while anesthetized sheep (n = 20) were ventilated with 0 cmH 2 O end-expiratory pressure. Clearance was remeasured during ventilation at 2.5, 5, 10, 15, or 20 cmH 2 O PEEP. Further studies showed stepwise increases in functional residual capacity (FRC) (P less than 0.05) measured at 0, 2.5, 5, 10, 15, and 20 cmH 2 O PEEP. At 2.5 cmH 2 O PEEP, the clearance rate was not different from that at base line (P less than 0.05), although FRC was increased from base line. Clearance rate increased progressively with increasing PEEP at 5, 10, and 15 cmH 2 O (P less than 0.05). Between 15 and 20 cmH 2 O PEEP, clearance rate was again unchanged, despite an increase in FRC. The pulmonary clearance of aerosolized /sup 99m/Tc-DTPA shows a sigmoidal response to increasing FRC and PEEP, having both threshold and maximal effects. This relationship is most consistent with the hypothesis that alveolar epithelial permeability is increased by lung inflation

  1. In-depth evaluation of the cycloaddition--retro-Diels--Alder reaction for in vivo targeting with [(111)In]-DTPA-RGD conjugates.

    NARCIS (Netherlands)

    Laverman, P.; Meeuwissen, S.A.; Berkel, S.S. van; Oyen, W.J.G.; Delft, F.L. van; Rutjes, F.P.J.T.; Boerman, O.C.

    2009-01-01

    INTRODUCTION: The spontaneous copper-free tandem 1,3-dipolar cycloaddition-retro-Diels-Alder (tandem crDA) reaction between cyclic Arg-Gly-Asp-d-Phe-Orn(N(3)) [c(RGDfX)] and oxanorbornadiene-DTPA (o-DTPA) or methyloxanorbornadiene-DTPA (mo-DTPA) into two DTPA-c(RGDfX) regioisomers is characterized.

  2. Effects of DTPA aerosol on lung contamination by lanthanum

    International Nuclear Information System (INIS)

    Pasquier, C.; Voisin, D.; Thieblement, P.; Perrault, G.; Bayard, J.

    1969-01-01

    Applying DTPA aerosol for the treatment of lung contamination by lanthanum we were able to determine its effectiveness as a function of time. Provided it was administered early during the two hours after exposure, over 50 per cent could be removed using lower therapeutic doses than those prescribed for other routes of administration. Its association with some enzymes did not enhance the chelator therapeutic effect. We also calculated the constant of passage of lanthanum through the alveolar wall and found a value of 0.016 mn -1 . Finally, as we have discovered a large part cannot be mobilized by DTPA, we shall now study the physico-chemical mechanisms involved in this protection. (authors) [fr

  3. Efficacy of Gd-DTPA-enhanced MRI in hypertrophic cardiomyopathy

    International Nuclear Information System (INIS)

    Okamoto, Shinya; Aoki, Toshikazu; Konishi, Tokuji; Nakano, Takeshi; Yamakado, Kyoichiro; Sakuma, Hajime; Takeda, Kann; Nakagawa, Takashi

    1991-01-01

    The cabability of magnetic resonance (MR) imaging to detect tissue characterization or myocardial degeneration process of the hypertrophied myocardium was evaluated in 15 patients with hypertrophic cardiomyopathy. T1-weighted MR images were obtained with a 1.5 T MR unit by using ECG-gated spin-echo techniques. MR images were visually reviewed before and after enhancement of Gd-DTPA. Four patients had an increase in signal intensity mainly in the endocardium of the left ventricular septum on non-enhanced MR images, 3 of whom had widespread high intensity in addition to two-thirds of the wall. Gd-DTPA enhanced-MR images showed high intensity over the whole septum in 5 patients and also in the antero-lateral endocardium in 4 patients. Decreased intensity on non-enhanced MR images, as shown in 4 patients, became clear on enhanced-MR images. According to findings on enhanced-MR images, signal intensity was defined as normal (N), septum (S), and diffuse (D). Patients in Group D tended to be younger and have more frequently family history. Regarding both interventricular septum thickness and left ventricular posterior wall thickness, there was no significant difference among the three groups. Both left ventricular diastolic diameter and left ventricular systolic diameter were significantly larger in Group D than the other two groups. Left ventricular ejection fraction was significantly lower in both Group S and Group D. Widespread abnormal intensity on Gd-DTPA enhanced MR images was associated with findings similar to dilated cardiomyopathy, such as dilated left ventricular lumen and decreased ejection fraction. Gd-DTPA enhanced MR imaging seemed to be useful for visualizing myocardial degeneration in hypertrophic cardiomyopathy.(N.K.)

  4. Gd-DTPA MR imaging enhancement of spinal cord tumors

    International Nuclear Information System (INIS)

    Dillon, W.P.; Bolla, K.; Mark, A.S.; Tsudura, J.S.; Norman, D.; Newton, T.H.

    1987-01-01

    Nineteen patients with suspected spinal cord tumors were imaged with T1- and T2-weighted sequences before and after the administration of Gd-DTPA (0.1 mmol/kg). Eleven of the 19 patients had spinal cord tumors (three unproven). Eight of 11 patients had intramedullary tumors (four astrocytomas, two ependymomas) and two had extra-medullary tumors (one meningioma, one metastatic melanoma). Other lesions studied include idiopathic syringomyelia (two), spinal arteriovenous malformation (AVM) (one), posttraumatic arachnoiditis (one), and cord infarct (one). All of the tumors enhanced after the administration of Gd-DTPA. Spinal cord enhancement was also noted in association with a spinal cord AVM, a suspected cord infarct, and in the patient with severe arachnoiditis. No enhancement was present in patients with idiopathic or posttraumatic syringomyelia or in the three normal patients. In six of the patients, enhancement was critical in confirming disease that was questionable on the precontrast MR images. Gadolinium enhancement allowed differentiation of tumor from postoperative changes in two patients with spinal cord tumors. Enhanced images localized the lesion more accurately than precontrast MR images in eight patients. In four patients a lesion could only be detected after the administration of contrast. The postcontrast images better defined the margin of tumor from surrounding edema, operative scarring, and cord cavitation. The AVM case had enhancement of slowly flowing veins with Gd-DTPA posterior to an ischemic cord segment. Gd-DTPA enhancement is extremely useful in the detection and therapeutic assessment of spinal cord tumors; however, enhancement is not specific for tumors and should be interpreted in light of the clinical setting

  5. Sequential MR images of uterus after Gd-DTPA injection

    International Nuclear Information System (INIS)

    Okada, Susumu; Kato, Tomoyasu; Yamada, Keiko; Sawano, Seishi; Yamashita, Takashi; Hirai, Yasuo; Hasumi, Katsuhiko

    1993-01-01

    To investigate the sequential changes in signal intensity (SI) of normal and abnormal uteri, T1-weighted images were taken repeatedly after the injection of Gd-diethylenetriaminepentaacetic acid (DTPA). Six volunteers and 19 patients with known uterine body malignancy (18 carcinomas, one carcinosarcoma) were examined. The results in volunteers were as follows. In the secretory phase, SI of the endometrium was stronger in the late images than in the early ones, whereas in the proliferative phase, SI was stronger in the early images. SI of the myometrium decreased rapidly and there were no differences in SI between menstrual phases. In 17 of 18 endometrial carcinomas, the tumors showed hypointensity relative to the myometrium, and the contrast between the tumor and the myometrium was better in the early images. In the remaining two cases, the tumor showed hyperintensity and the contrast was better in the late images. After the injection of Gd-DTPA, the endometrium appeared differently according to the menstrual cycle in normal volunteers, and the appearance of uterine structures and endometrial malignant tumors changed sequentially. These findings must be kept in mind when evaluating uterine diseases by Gd-DTPA enhanced MRI. (author)

  6. Glomerular filtration in kidney recipients measured by plasma clearance of 169Yb-DTPA

    International Nuclear Information System (INIS)

    Stribrna, J.; Oppelt, A.; Jirickova, E.; Janata, V.; Kocandrle, V.; Sup, I.; Woller, P.; Franke, W.G.

    1986-01-01

    Values of 169 Yb-DTPA clearance (C DTPA ) calculated after a single injection were compared in 26 recipients of kidneys with renal clearance of inulin (C in ), polyfructosan S (C pf ) and creatinine (C cr ). In 21 patients the examinations were made simultaneously, in 5 patients C DTPA was measured within a short interval after the examination of renal clearance. The mean C DTPA values did not significantly differ from C cr but were significantly higher (p in and C pf (by 33% on average). Investigation of changes in C DTPA as compared with C in and C pf showed no significant difference in glomerular filtration (GF). This was measured using inulin and polyfructosan. The results showed that the differing molecular weight of inulin and polyfructosan S had no detectable effect on the GF of kidney recipients. The plasma clearance of 169 Yb-DTPA similarly to C cr overestimates the GF measured by inulin and polyfructosan clearance. (author)

  7. Effects of DTPA aerosol on lung contamination by lanthanum; Influence du DTPA en aerosol sur les contaminations pulmonaires au lanthane

    Energy Technology Data Exchange (ETDEWEB)

    Pasquier, C.; Voisin, D.; Thieblement, P.; Perrault, G.; Bayard, J. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1969-07-01

    Applying DTPA aerosol for the treatment of lung contamination by lanthanum we were able to determine its effectiveness as a function of time. Provided it was administered early during the two hours after exposure, over 50 per cent could be removed using lower therapeutic doses than those prescribed for other routes of administration. Its association with some enzymes did not enhance the chelator therapeutic effect. We also calculated the constant of passage of lanthanum through the alveolar wall and found a value of 0.016 mn{sup -1}. Finally, as we have discovered a large part cannot be mobilized by DTPA, we shall now study the physico-chemical mechanisms involved in this protection. (authors) [French] L'emploi du DTPA en aerosol dans le traitement des contaminations pulmonaires par le lanthane, nous a permis d'etablir et d'evaluer son efficacite en fonction du temps. A condition d'etre utilise precocement, dans les deux heures qui suivent la contamination, une fraction superieure a 50 pour cent peut etre eliminee et ceci avec des doses therapeutiques inferieures a celles preconisees pour les autres voies d'administration. L'association avec quelques autres enzymes n'a pas permis d'ameliorer l'effet therapeutique de ce chelateur. Nous avons egalement chiffre la constante de passage du lanthane a travers la barriere alveolaire dont la valeur est de l'ordre de 0.016 mn{sup -1} Enfin, la decouverte d'une importante partie non piegeable par le DTPA nous amene maintenant a etudier les mecanismes physico-chimiques de cette protection. (auteurs)

  8. Lutetium-177 complexation of DOTA and DTPA in the presence of competing metals

    International Nuclear Information System (INIS)

    Watanabe, Satoshi; Ishioka, Noriko S.; Hashimoto, Kazuyuki

    2013-01-01

    177 Lu complexation of DOTA and DTPA is investigated by the addition of Ca(II), Fe(II) and Zn(II). The 177 Lu complexation yield of DTPA was higher than that of DOTA in the presence of Ca(II), Fe(II) and Zn(II). Therefore, it was found that the 177 Lu complexation of DTPA was more advantageous compared with DOTA in the presence of competing metals, Ca, Fe and Zn. (author)

  9. Gd-DTPA: Clinical use in MR imaging of postoperative lumbar recurrent disk herniation and fibrosis

    International Nuclear Information System (INIS)

    Narang, A.K.; Hueftle, M.; Williams, A.; Modic, M.; Davis, D.O.

    1987-01-01

    Gd-DTPA, a paramagnetic MR contrast agent, is most familiarly utilized for delineation of brain and cord abnormalities. Since contrast-enhanced CT may help distinguish epidural fibrosis from recurrent herniated lumbar disk, the efficacy of Gd-DTPA-enhanced MR imaging was evaluated. Symptomatic patients with previous back surgery are being evaluated with pre- and post-Gd-DTPA T1- and T2-weighted images. Results to date (over 40 cases) suggest that this technique will be extremely helpful

  10. Actinides exposure: review of Ca-DTPA injections inside Cea-Cogema plants; Exposition aux actinides: bilan des injections de Ca-DTPA dans les centres CEA-Cogema

    Energy Technology Data Exchange (ETDEWEB)

    Grappin, L.; Berard, P.; Beau, P.; Carbone, L.; Castagnet, X.; Courtay, C.; Le Goff, J.P.; Menetrier, F.; Neron, M.; Piechowski, J. [CEA Cadarache, Dir. de l' Energie Nucleaire, Dept. de Soutien en surete et securite, Sev. de Sante au Travail, 13 - Saint-Paul-lez-Durance (France)

    2006-07-01

    Ca-DTPA has been used for medical treatment of plutonium and americium contaminations in the CEA and COGEMA plants from 1970 to 2003. This report is a survey of the injections administered of Ca-DTPA as a chelating molecule. This report will be a part of the AMM process for Ca-DTPA by intravenous administration submitted by the Central Pharmacy of the french Army. Out of 1158 injections administered to 469 persons, 548 events of possible or confirmed contaminations were reported. These employees were followed by occupational physicians according to the current regulations. The first part of the report is a synthesis of the most recent findings. Due to its short biological period and its limited action in the blood, Ca-DTPA does not chelate with plutonium and americium as soon as these elements are deposited in the target organs. It justifies an early treatment, even in cases of suspected contamination followed by additional injections if necessary. The second part presents data concerning these 1158 injections (way of contamination, posology, adverse effects...). These incidents took place at work, were most often minor, not requiring follow-up treatment. A study concerning the effectiveness of the product was done on a group of people having received 5 or more injections. These results were compared with effectiveness estimated from theoretical basis. Posologies and therapeutic schemes were proposed based on these observations. Additional studies are needed to confirm these findings. This document is the first synthesis in this field. It is the result of a collective work having mobilized the occupational medicine departments, the laboratories of CEA and COGEMA and a working group CEA-COGEMA-SPRA. (authors)

  11. An analysis of 99mTc-DTPA renal dynamic imaging in patients with diabetes mellitus

    International Nuclear Information System (INIS)

    Cao Guoxiang; Zhang Yongxue

    2000-01-01

    To investigate the regularity of renal dynamic imaging in the various courses of diabetes mellitus, and then to provide the important evidence variety for diagnosis and treatment. The data of renal dynamic imaging was analyzed on 276 kidneys of 40 normal and 98 diabetic patients, and according to course of disease, the diabetic patients was divided into three groups: ≤1 year, 1-5 year and ≥5 year respectively. Based upon was grouped 99m Tc-DTPA renal dynamic imaging and others, the renal functions into normal, approximately normal, I, II and III injury respectively, and the statistics and analysis of these data were carried out. The extent of renal function injury was related to the course of disease significantly, and it showed that the longer the course, the heavier the damage of renal function, and there was a significant difference between them (P 99m Tc-DTPA renal dynamic imaging can effectively evaluate the extent of renal functions injury and was also valuable for the clinical. Also, the study indicated that in diabetic patients susceptible to urinary tract infection could aggravate the injury of renal function

  12. Clinical experience of adverse drug reaction in gadolinium-DTPA enhancement of MRI

    International Nuclear Information System (INIS)

    Kim, Mi Hyae; Hong, Ju Hee; Lee, Yeon Su; Cha, Kyung Soo; Chang, Suk Il; Lee, Young Chul; Kim, Yeong Soo

    1992-01-01

    Gadopentetate dimenglumine(Gd-DTPA) has low toxicity and good tolerance and it is said that the observed adverse drug reaction of Gd-DTPA is compatible to those of iodinated nonionic contrast media. The overall incidence of adverse drug reaction of Gd-DTPA is even lower than those of iodinated nonionic contrast media. Then, the possibility of potential adverse drug reaction of these contrast media is not fully known and recently, many authors have a growing interest in this point. We have taken 2501 cases of MRI and executed 1467 case of Gd-DTPA enhancement scanning(58.7%) and experienced 12 cases of adverse drug reaction(11 cases: mild reaction, 1 case: severs anaphylactic shock) and the overall incidence of our adverse drug reaction of Gd-DTPA was 0.8%. In conclusion, the adverse drug reaction of Gd-DTPA is not rare and the severe adverse drug reaction of Gd-DTPA may occur. So, the possibility of adverse drug reaction after Gd-DTPA injection should always be kept in mind, especially when the patient has a history of reaction to contrast material, allergy(particularly asthma) and cardiac disease. For the safe use of Gd-DTPA, well trained personnel and nearby emergent care facilities should be available

  13. Clinical experience of adverse drug reaction in gadolinium-DTPA enhancement of MRI

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Mi Hyae; Hong, Ju Hee; Lee, Yeon Su; Cha, Kyung Soo; Chang, Suk Il [Sung Ae Gernral Hospital, Seoul (Korea, Republic of); Lee, Young Chul; Kim, Yeong Soo [Chung Ang University Colege of Medicine, Seoul (Korea, Republic of)

    1992-03-15

    Gadopentetate dimenglumine(Gd-DTPA) has low toxicity and good tolerance and it is said that the observed adverse drug reaction of Gd-DTPA is compatible to those of iodinated nonionic contrast media. The overall incidence of adverse drug reaction of Gd-DTPA is even lower than those of iodinated nonionic contrast media. Then, the possibility of potential adverse drug reaction of these contrast media is not fully known and recently, many authors have a growing interest in this point. We have taken 2501 cases of MRI and executed 1467 case of Gd-DTPA enhancement scanning(58.7%) and experienced 12 cases of adverse drug reaction(11 cases: mild reaction, 1 case: severs anaphylactic shock) and the overall incidence of our adverse drug reaction of Gd-DTPA was 0.8%. In conclusion, the adverse drug reaction of Gd-DTPA is not rare and the severe adverse drug reaction of Gd-DTPA may occur. So, the possibility of adverse drug reaction after Gd-DTPA injection should always be kept in mind, especially when the patient has a history of reaction to contrast material, allergy(particularly asthma) and cardiac disease. For the safe use of Gd-DTPA, well trained personnel and nearby emergent care facilities should be available.

  14. The use of EDTA and DTPA for accelerating the removal of deposited transuranic elements from humans

    CERN Document Server

    Spoor, N L

    1977-01-01

    EDTA and DTPA have been prominent among the chelating agents used to increase the rate of excretion of certain deposited heavy metals from the human body. Since 1959, DTPA, administered either by intravenous injection or by aerosol inhalation, has been widely used to treat workers contaminated by plutonium or a higher actinide. In this report, an attempt is made to assess the toxicities of EDTA and DTPA and to evaluate the effectiveness and safety of DTPA as a drug for removing deposited transuranic elements.

  15. Treatment with Ca-DTPA of internal contaminations by plutonium and americium: Recommendations for writing protocols in Cea and AREVA centers; Traitement par le Ca-DTPA des contaminations internes par le plutonium et l'americium: recommandations pour la redaction de protocoles dans les centres CEA et AREVA

    Energy Technology Data Exchange (ETDEWEB)

    Grappin, L. [CEA Cadarache, DEN, Service de Sante au Travail, 13 - Saint-Paul-lez-Durance (France); Legoff, J.P.; Andre, F. [CEA Valduc, Service de Sante au Travail, 21 - Is-sur-Tille (France); Carbone, L.; Agrinier, A.L. [CEA Marcoule, DEN, Service de Sante au Travail, 30 (France); Courtay, C.; Aninat, M. [AREVA, Service de Sante au Travail, La Hague, 50 - Beaumont-Hague (France); Amabile, J.C. [SPRA, HIA Percy, 92 - Clamart (France); Florin, A. [CEA Saclay, SDM Service de Sante au Travail, 91 - Gif-sur-Yvette (France)

    2009-10-15

    The purpose of this document is to provide physicians working in a B.N.F. (Basic Nuclear Facility) with recommendations for the drafting of Ca-DTPA treatment protocols for internal contamination by actinides. These recommendations are based on the results of injections carried out by Cea and AREVA doctors in a working group, with the collaboration of the Army Radiation Protection Service. The study focused on Ca-DTPA IV injection. Other dosage forms, routes of administration as well as adjuvant treatments are also mentioned. For cases of contaminated wounds and inhalation, indicators for treatment with Ca-DTPA, particularly its initialization, the dosage, duration, frequency of administration, the criteria for ending the treatment, then its efficiency and dosimetry gain are covered. A guide for the prescription of the radio toxicological monitoring necessary for the treatment and the dosimetric evaluation is proposed. (authors)

  16. In vitro stability of EDTA and DTPA immunoconjugates of monoclonal antibody 2G3 labeled with indium-111

    Energy Technology Data Exchange (ETDEWEB)

    Reilly, R.; Lee, N.; Houle, S. (The Toronto Hospital (Canada)); Law, J.; Marks, A. (Toronto Univ., ON (Canada))

    1992-08-01

    Monoclonal antibody 2G3 directed against a high molecular weight glycoprotein on breast and ovarian cancer cells was conjugated with bicyclic DTPA (or EDTA) anhydride or benzyl isothiocyanate DTPA (benzyl DTPA) and labeled with {sup 111}In. DTPA anhydride was more reactive with the antibody than benzyl DTPA, and kinetics of labeling with {sup 111}In were more rapid for DTPA substituted 2G3 than for benzyl DTPA substituted 2G3. On the other hand, {sup 111}In-2G3 conjugates prepared using DTPA anhydride were subject to more extensive dimerization and higher losses in immunoreactivity than those prepared using benzyl DTPA. On the basis of measurement of transchelation to transferrin, the stability of {sup 111}In-2G3 prepared using DTPA anhydride or benzyl DTPA did not differ during incubation in human plasma for 6 days at 37{sup o}C. These results suggest that an important advantage of benzyl DTPA over DTPA anhydride for preparing {sup 111}In-labeled antibodies is the prevention of intermolecular (and intramolecular) crosslinking during conjugation which ultimately leads to alterations in conformation and losses in immunoreactivity of the radioimmunoconjugate. (author).

  17. Significance of contrast enhancement with Gd-DTPA in evaluation of pituitary adenomas; Znaczenie wzmocnienia kontrastowego Gd-DTPA w ocenie gruczolakow przysadki

    Energy Technology Data Exchange (ETDEWEB)

    Paprzycki, W.; Liebert, W.; Gradzki, J.; Sosnowski, P.; Stajgis, M. [Osrodek Diagnostyki Obrazowej IR, Akademia Medyczna, Poznan (Poland)]|[Zaklad Neuroradiologii, Akademia Medyczna, Poznan (Poland)]|[Klinika Neurochirurgii, Akademia Medyczna, Poznan (Poland)

    1994-12-31

    Results of MR examinations in 136 patients with suspected pituitary adenoma were evaluated retrospectively. Presence of 40 microadenomas and 48 macroadenomas was confirmed. Contrast enhancement with Gd-DTPA increased diagnostic efficacy in 65% of cases of microadenomas. Contrast enhancement with Gd-DTPA was less useful in cases of macroadenomas and enable the more detailed evaluation of tumor margins in 31 %, tumor relation to cavernous sinus in 21% and tumor relation to optic chiasm in 6% of cases only. Authors suggest, that contrast enhancement with Gd-DTPA is indispensable and should be performed routinely in evaluation of pituitary gland in patients with suspected microadenoma. (author) 10 refs, 5 figs, 3 tabs

  18. USTUR WHOLE BODY CASE 0269: DEMONSTRATING EFFECTIVENESS OF I.V. CA-DTPA FOR PU

    Energy Technology Data Exchange (ETDEWEB)

    James, Anthony C.; Sasser , Lyle B.; Stuit, Dorothy B.; Glover, Samuel E.; Carbaugh, Eugene H.

    2008-01-28

    This whole body donation case (USTUR Registrant) involved a single acute inhalation of an acidic Pu(NO3)4 solution in the form of an aerosol ‘mist.’ Chelation treatment with i.v. Ca-EDTA was initiated on the day of the intake, and continued intermittently over 6 months. After 2½ years with no further treatment, a course of i.v. Ca-DTPA was administered. A total of 400 measurements of 239+240Pu excreted in urine were recorded; starting on the first day (both before and during the initial Ca-EDTA chelation), and continuing for 37 years. This sampling included all intervals of chelation. In addition, 91 measurements of 239+240Pu-in-feces were recorded over this whole period. The Registrant died about 38 years after the intake, at age 79 y, with extensive carcinomatosis secondary to adenocarcinoma of the prostate gland. At autopsy, all major soft tissue organs were harvested for radiochemical analyses of their 238Pu, 239+240Pu and 241Am content. Also, all types of bone (comprising about half the skeleton) were harvested for radiochemical analyses, as well as samples of skin, subcutaneous fat and muscle. This comprehensive dataset has been applied to derive ‘chelation-enhanced’ transfer rates in the ICRP Publication 67 plutonium biokinetic model, representing the behaviour of blood-borne and tissue-incorporated plutonium during intervals of therapy. The resulting model of the separate effects of i.v. Ca-EDTA and Ca-DTPA chelation shows that the therapy administered in this case succeeded in reducing substantially the long-term burden of plutonium in all body organs, except for the lungs. The calculated reductions in organ content at the time of death are approximately 40% for the liver, 60% for other soft tissues (muscle, skin, glands, etc.), 50% for the kidneys, and 50% for the skeleton. Essentially all of the substantial reduction in skeletal burden occurred in trabecular bone. This modeling exercise demonstrated that 3-y-delayed Ca-DTPA therapy was as

  19. Ustur whole body case 0269: demonstrating effectiveness of i.v. CA-DTPA for Pu

    Energy Technology Data Exchange (ETDEWEB)

    James, A.C.; Sasser, L.B.; Stuit, D.B. [US Transuranium and Uranium Registries, College of Pharmacy, Washington State University, 1845 Terminal Drive, Suite 201, Richland, WA 99354 (United States); Glover, S.E. [Department of Mechanical, Industrial and Nuclear Engineering, University of Cincinnati, 598 Rhodes Hall, Cincinnati, OH 45221 (United States); Carbaugh, E.H. [Pacific Northwest National Laboratory, PO Box 999, Richland, WA 99354 (United States)

    2007-07-01

    This whole body donation case (USTUR Registrant) involved a single acute inhalation of an acidic Pu(NO{sub 3}){sub 4} solution in the form of an aerosol 'mist'. Chelation treatment with intravenously (i.v.) Ca-EDTA was initiated on the day of the intake, and continued intermittently over 6 months. After 2.5 y with no further treatment, a course of i.v. Ca-DTPA was administered. A total of 400 measurements of {sup 239+240}Pu excreted in urine were recorded; starting on the first day (both before and during the initial Ca-EDTA chelation) and continuing for 37 y. This sampling included all intervals of chelation. In addition, 91 measurements of {sup 239+240}Pu-in-feces were recorded over this whole period. The Registrant died about 38 y after the intake, at age 79 y, with extensive carcinomatosis secondary to adenocarcinoma of the prostate gland. At autopsy, all major soft tissue organs were harvested for radiochemical analyses of their {sup 238}Pu, {sup 239+240}Pu and {sup 241}Am content. Also, all types of bone (comprising about half the skeleton) were harvested for radiochemical analyses, as well as samples of skin, subcutaneous fat and muscle. This comprehensive data set has been applied to derive 'chelation-enhanced' transfer rates in the ICRP Publication 67 plutonium biokinetic model, representing the behaviour of blood-borne and tissue-incorporated plutonium during intervals of therapy. The resulting model of the separate effects of i.v. Ca-EDTA and Ca-DTPA chelation shows that the therapy administered in this case succeeded in reducing substantially the long-term burden of plutonium in all body organs, except for the lungs. The calculated reductions in organ content at the time of death are {approx}40% for the liver, 60% for other soft tissues (muscle, skin, glands, etc.), 50% for the kidneys and 50% for the skeleton. Essentially, all of the substantial reduction in skeletal burden occurred in trabecular bone. This modelling exercise

  20. Preparation of γ-immunoglobulins coupled with DTPA and their labelling with trivalent metal radionuclides for radiotherapy

    International Nuclear Information System (INIS)

    Rekova, M.; Miler, V.; Budsky, F.; Malek, Z.; Prokop, J.; Prazak, Z.

    2007-06-01

    The scope of the report is as follows: immunoglobulin coupling with cDTPAA and labelling of the conjugate with 90 Y; Acid-base and complexation equilibria in the coupled immunoglobulin solution; Theory of the complex equilibrium of yttrium between coupled immunoglobulin and EDTA; and Procedures and results of recent experiments. The following was achieved: (i) The dependence of the bovine immunoglobulin on the cDTPAA/IgG coupling ratio and immunoglobulin concentration was obtained; (ii) A procedure aimed to free phosphate buffer from ubiquitous trivalent cations was tested; (iii) The procedure of lyophilization of coupled bovine IgG-DTPA in a phosphate buffer at pH 7.34 and I = 0.16 mol.l -1 .was elaborated. (iv) A procedure for lyophilization of the coupled CD20 monoclonal antibody in the same phosphate buffer was elaborated. (v) Acid-base and complexation equilibria were calculated for citrate and phosphate buffer solutions in the presence of coupled immunoglobulin. ( vi) A theory of the complexation equilibrium of yttrium between coupled immunoglobulin and EDTA was developed. (vii) Experiments were performed leading to the determination of a so far unknown constant of complexity of yttrium to DTPA coupled to immunoglobulin; its 3rd and 4th dissociation constants. (viii) The method sub (vii) can be applied to the determination of the complexity constants of other radionuclides with DTPA coupled to immunoglobulin; the 3rd and 4th dissociation constants of IgG-DTPA will not have to be sought any more. (ix) Samples of lyophilizate of the Y-CD20-DTPA complex can be sent to the biochemical laboratory for immunoreactivity determination. (x) Lyophilizates from experiments (iv-vi) are stored in a refrigerator at 4 deg C to be used for labelling with 177 Lu. (xi) The results obtained can be used to plan an experiment with CD20 in which a specific radioactivity of 400 MBq 177 Lu per mg CD20 will be achieved. (P.A.)

  1. Biliary enhanced MR imaging by Gd-DTPA

    International Nuclear Information System (INIS)

    Ohkawa, Shinichi; Fujikura, Yuji; Kanai, Toshio; Hiramatsu, Kyoichi.

    1992-01-01

    Biliary enhanced MRI (BEMRI) by Gd-DTPA via PTCD and/or PTGBD tube for obstructive jaundice was performed in 8 patients. In all cases, biliary tract was clearly visualised as high signal intensity on T1 weighted images. On same images, primary lesion such as common bile duct cancer was also visualised as well as portal system. In addition, MR angiography (MRA) by 2D-time of flight method was performed. MRA with BEMRI shows portal encasement on the same image as biliary tract obstruction. This suggests MRA with BEMRI may replace the other modality for obstructive jaundice. (author)

  2. Sequential gadolinium-DTPA enhanced MRI studies in neuro-Behcet's disease

    International Nuclear Information System (INIS)

    Kazui, S.; Naritomi, H.; Ogawa, M.; Sawada, T.; Imakita, S.; Yamada, N.

    1991-01-01

    Sequential gadolinium-DTPA (Gd-DTPA) enhanced MR images were obtained before and after steroid therapy in a case of neuro-Behcet's disease. Multiple scattered lesions, which could not be detected on pre- and post-contrast CT, were demonstrated mainly in the white matter of the pons and/or the cerebrum with both T1- and T2-weighted images. Some of these lesions, however, were not enhanced at all by infusion of Gd-DTPA. The Gd-DTPA infusion study demonstrated marked enhancement in the white matter of the pons and cerebrum. Some lesions not seen with T2-weighted images were also strongly enhanced by Gd-DTPA infusion at the acute stage. After steroid therapy, the symptoms and abnormal laboratory findings were resolved. The pontine and cerebral lesions on plain MR images remained unchanged even after resolution of the symptoms, suggesting that they were inactive old foci. On the other hand, the lesions detected in the enhancement study before steroid therapy disappeared with the repeat Gd-DTPA enhanced MR images which were performed after resolution of the symptoms. Some active inflammatory lesions in neuro-Behcet's disease may be demonstrated only on Gd-DTPA enhanced MR images. Gd-DTPA enhanced MR imaging appears to be potentially useful for detecting active inflammatory lesions in neuro-Behcet's disease and for evaluating the efficacy of treatment. (orig.)

  3. Toxicological study of DTPA as a drug, 6; Effects of intravenously injected Ca-DTPA, Ca-EDTA, CBMIDA and orally administered Zn-DTPA to bone metabolism in beagle dogs

    Energy Technology Data Exchange (ETDEWEB)

    Fukuda, Satoshi; Iida, Haruzo (National Inst. of Radiological Sciences, Chiba (Japan)); Hseih Yuyuan; Chen Wehzhi

    1991-06-01

    Effects of four kinds of chelating agents, Ca-DTPA (calcium diethylenetriaminepentaacetic acid), Ca-EDTA (calcium ethylenediaminetetraacetic acid), CBMIDA (catechol-3, 6-bis(methyleiminodiacetic acid)) and Zn-DTPA (zinc DTPA), on bone metabolism were examined in beagle dogs by bone histomorphometry and measurement of serum biochemical constituents related to bone metabolism. Ca-DTPA, Ca-EDTA or CBMIDA (150 {mu}mol/kg) was injected intravenously to dogs for 1 month, respectively. Three doses (30, 150 and 300 {mu}mol/kg) of Zn-DTPA were administered orally to dogs for 1 month, respectively. All dogs received twice tetracycline hydrochloride injections at an interval of 7 days before the beginning of administration of chelating agents and also twice calcein injections at the same time schedule prior to sacrifices for analyzing bone dynamics. Bone samples were obtained from ilium and undecalcified bone sections were made. Bone histomorphometry of cancellous bone area of ilium was performed using an image analyzer. Bone volume and mean trabecular thickness did not change in any of the groups. Osteoid volume in the CBMIDA group increased. Osteoid volume and mean osteoid thickness in the 150 {mu}mol/kg of Zn-DTPA group decreased. Mineral apposition rate and bone formation rate did not change in any groups except the CBMIDA and 150 {mu}mol/kg of Zn-DTPA groups, in which fluorescent bone labeling was absent or obscure, revealing inhibition of bone mineralization. Serum total calcium levels did not change in any of the groups. Serum phosphorus level decreased significantly in the 30 {mu}mol/kg dose of Zn-DTPA group. Parathyroid hormone level increased in the 30 {mu}mol/kg dose of Zn-DTPA, while it decreased in the 150 {mu}mol/kg dose of Zn-DTPA group. The results suggests that the protracted therapy using the above four kinds of chelating agents may incur damages of bone such as decrease of bone volume and inhibition of mineralization. (author).

  4. Uptake of 153Sm-DTPA-bis-biotin and 99mTc-DTPA-bis-biotin in rat as-30D-hepatoma cells

    International Nuclear Information System (INIS)

    Correa-Gonzalez, Luis; Arteaga de Murphy, Consuelo; Ferro-Flores, Guillermina; Pedraza-Lopez, Martha; Murphy-Stack, Eduardo; Mino-Leon, Dolores; Perez-Villasenor, Graciela; Diaz-Torres, Yaneth; Munoz-Olvera, Rodrigo

    2003-01-01

    Labeled biotin has been used mainly for pretargeted therapy, an approach for increasing the amount of radioactivity delivered to a cancer cell. The aim of this investigation was to prepare 153 Sm-DTPA-bis-biotin and 99m Tc-DTPA-bis-biotin in order to study their in vitro and in vivo uptake in rat AS-30D hepatoma cells found in ascites and in implanted tumor. DTPA-bis-biotin (pH 8) was 153 Sm labeled with 153 SmCl 3 and 99m Tc-DTPA-bis-biotin was prepared via SnCl 2 reduction. Radiochemical purity was >98% in both cases. AS-30D hepatoma cells were obtained from ascites of a rat with hepatoma and were propagated in the peritoneum cavity of normal rats. In vitro ascites cell 153 Sm-DTPA-bis-biotin uptake was compared with 153 SmCl 3 cell uptake. The ratio cell 153 Sm-DTPA-bis-biotin/ 153 SmCl 3 was 39.6 and when avidin was added it increased to 50. The ratio 99m Tc-DTPA-bis-biotin/TcO 4 Na was 8.7. Concentration of 153 Sm-DTPA-bis-biotin in tumor 2, 3 and 24 h after administration, was 5, 15 and 3 times higher than in normal muscle (T/nT). Biodistribution in a 0.083-24 h time period showed that 153 Sm-DTPA-bis-biotin was taken up only by ascites tumor cells and hepatoma cells. Two and 3 h ratio ascites/liver (As/Lv) was 6.4 and 6.0. For 99m Tc-DTPA-bis-biotin 2 and 3 h T/nT was 15.7 and 4.7 and 2 h As/Lv was 1.4. In conclusion, both radiopharmaceuticals show high uptake in rat AS-30D hepatoma cells in ascites and in implanted tumor. Since lung, thyroid, kidney, liver or pancreas carcinomas are ascites producing cancers 153 Sm-DTPA-bis-biotin would be an adequate therapeutic radiopharmaceutical for these patients whose life quality would be enhanced with control of ascites, and a reduction of the primary tumor and its metastases

  5. Gd-DTPA-enhanced MR in thoracic disc herniations

    Energy Technology Data Exchange (ETDEWEB)

    Parizel, P.M.; Rodesch, G.; Baleriaux, D.; Segebarth, C.; Zegers de Beyl, D.; Haens, J. d' ; Noterman, J.

    1989-03-01

    The Gd-DTPA-enhanced magnetic resonance findings in two patients with herniated thoracic intervertebral discs are reported. The first patient was a 56-year-old woman with a small subligamentous T6-7 disc herniation, slightly lateralized to the right. The second patient was a 51-year-old man with a central and right posterolateral disc herniation, including a large calcified fragment, at the T8-9 level. The nonenhanced MR examination revealed the presence of an extradural mass lesion in both patients, impinging upon the dural sac and compressing and displacing the spinal cord posteriorly. The lesion was slightly hypointense on both T1- and T2-weighted spin echo sequences. Following intravenous injection of Gd-DTPA in a dosage of 0.1 mmol/kg body weight, enhancement of the posterior longitudinal ligament was noted and triangular areas of contrast uptake were seen to occur in the epidural space above and below the herniated disc. At surgery, they were found to correspond to dilated and congested epidural veins.

  6. High-hardness ceramics based on boron carbide fullerite derivatives

    Science.gov (United States)

    Ovsyannikov, D. A.; Popov, M. Yu.; Perfilov, S. A.; Prokhorov, V. M.; Kulnitskiy, B. A.; Perezhogin, I. A.; Blank, V. D.

    2017-02-01

    A new type of ceramics based on the phases of fullerite derivatives and boron carbide B4C is obtained. The material is synthesized at a temperature of 1500 K and a relatively low pressure of 4 GPa; it has a high hardness of 45 GPa and fracture toughness of 15 MPa m1/2.

  7. Cell-based lipid flippase assay employing fluorescent lipid derivatives

    DEFF Research Database (Denmark)

    Jensen, Maria Stumph; Costa, Sara; Günther-Pomorski, Thomas

    2016-01-01

    , studies of individual P4-ATPase family members from fungi, plants, and animals show that P4-ATPases differ in their substrate specificities and mediate transport of a broader range of lipid substrates. Here, we describe an assay based on fluorescent lipid derivatives to monitor and characterize lipid...

  8. FACE RECOGNITION BASED ON LOCAL DERIVATIVE TETRA PATTERN

    Directory of Open Access Journals (Sweden)

    A Geetha

    2017-02-01

    Full Text Available This paper proposes a new face recognition algorithm called local derivative tetra pattern (LDTrP. The new technique LDTrP is used to alleviate the face recognition rate under real-time challenges. Local derivative pattern (LDP is a directional feature extraction method to encode directional pattern features based on local derivative variations. The nth -order LDP is proposed to encode the first (n-1th order local derivative direction variations. The LDP templates extract high-order local information by encoding various distinctive spatial relationships contained in a given local region. The local tetra pattern (LTrP encodes the relationship between the reference pixel and its neighbours by using the first-order derivatives in vertical and horizontal directions. LTrP extracts values which are based on the distribution of edges which are coded using four directions. The LDTrP combines the higher order directional feature from both LDP and LTrP. Experimental results on ORL and JAFFE database show that the performance of LDTrP is consistently better than LBP, LTP and LDP for face identification under various conditions. The performance of the proposed method is measured in terms of recognition rate.

  9. Unexpected side products in the conjugation of an amine-derivatized morpholino oligomer with p-isothiocyanate benzyl DTPA and their removal

    Energy Technology Data Exchange (ETDEWEB)

    Liu Guozheng, E-mail: guozheng.liu@umassmed.ed [Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655 (United States); Dou Shuping; Liu Yuxia; Liang Minmin; Chen Ling; Cheng Dengfeng [Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655 (United States); Greiner, Dale [Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655 (United States); Rusckowski, Mary; Hnatowich, Donald J. [Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655 (United States)

    2011-02-15

    In connection with pretargeting, an amine-derivatized morpholino phosphorodiamidate oligomer (NH{sub 2}-cMORF) was conjugated conventionally with p-isothiocyanate benzyl-DTPA (p-SCN-Bn-DTPA). However, after {sup 111}In radiolabeling, unexpected label instability was observed. To understand this instability, the NH{sub 2}-cMORF and, as control, the native cMORF without the amine were conjugated in the conventional manner. Surprisingly, the {sup 111}In labeling of the native cMORF conjugate was equally effective as that of the NH{sub 2}-cMORF conjugate (>95%) despite the absence of the amine group. Furthermore, heating the radiolabeled NH{sub 2}-cMORF and native cMORF conjugates resulted in a 35% loss and a complete loss of the label, respectively. Since the {sup 111}In labeled DTPA is known to be stable, the instability in both cases must be due to some unstable association of DTPA to the cMORF, presumably unstable association to some endogenous sites in cMORF. Based on this assumption, a postconjugation-prepurification heating step was introduced, and labeling efficiency and stability were again investigated. By introducing the heating step, the side products were dissociated, and after purification and labeling, the NH{sub 2}-cMORF conjugate provided a stable label and high labeling efficiency with no need for postlabeling purification. The biodistribution of this radiolabeled conjugate in normal mice showed significantly lower backgrounds compared with the labeled unstable native cMORF conjugate. In conclusion, the conventional conjugation procedure to attach the p-SCN-Bn-DTPA to NH{sub 2}-cMORF resulted in side product(s) that were responsible for the {sup 111}In label instability. Adding a postconjugation-prepurification heating step dissociated the side products, improved the label stability and lowered tissue backgrounds in mice.

  10. Spectroscopic studies on interaction of BSA and Eu(III) complexes with H5ph-dtpa and H5dtpa ligands.

    Science.gov (United States)

    Kong, Deyong; Qin, Cui; Fan, Ping; Li, Bing; Wang, Jun

    2015-04-05

    An novel aromatic aminopolycarboxylic acid ligand, N-(2-N,N-Dicarboxymethylaminophenyl) ethylenediamine-N,N',N'-triacetic acid (H5ph-dtpa), was synthesized by improving experimental method and its corresponding Eu(III) complex, Na2[EuIII(ph-dtpa)(H2O)]·6H2O, was successfully prepared through heat-refluxing method. As a comparison, the Eu(III) complex with diethylenetriamine-N,N,N',N',N″-pentaacetic acid (H5dtpa) ligand, Na2[Eu(III)(dtpa)(H2O)]·6H2O, was also prepared by the same method. And then, the interaction between prepared Eu(III) complexes ([EuIII(dtpa)(H2O)]2- and [EuIII(ph-dtpa)(H2O)]2-) and bovine serum albumin (BSA) in aqueous solution were studied by the combination of ultraviolet-visible (UV-vis), fluorescence and circular dichroism (CD) spectroscopies. In addition, the binding sites of Eu(III) complexes ([EuIII(dtpa)(H2O)]2- and [EuIII(ph-dtpa)(H2O)]2-) to BSA molecules were also estimated by synchronous fluorescence. Moreover, the theoretical and experimental results show that the Van der Waals, hydrogen bond and π-π stacking interactions are the mainly impulse to the reaction. The binding distances (r) between Eu(III) complexes ([EuIII(dtpa)(H2O)]2- and [EuIII(ph-dtpa)(H2O)]2-) and BSA were obtained according to Förster's non-radiative energy transfer theory. Also, the determined UV-vis absorption spectroscopy, synchronous fluorescence and circular dichroism (CD) spectra showed that the conformation of BSA could be changed in the presence of Eu(III) complexes. The obtained results can help understand the action mode between rare earth metal complexes of aminopolycarboxylic acid ligands with BSA and they are also expected to provide important information of designs of new inspired drugs. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Tl-201 and Tc-99m-DTPA neuro-SPECT in cerebral radiation necrosis

    International Nuclear Information System (INIS)

    Cleto, E.M. Jr.; Holmes, R.A.; Gumerlock, M.K.; Cabeen, M.; Logan, K.W.; Hoffman, T.J.

    1992-01-01

    The results in 3 cases of radiation necrosis demonstrate that by using both radionuclides Tl-201 and Tc-99m-DTPA, one can provide a semi-quantitative method to differentiate recurrent tumor from radiation necrosis. Focally increased cerebral Tl-201 activity in irradiated brain tumor patients is not specific for tumor recurrence, but when used in combination with DTPA, one is able to estimate the amount of Tl-201 activity resulting from increased blood-brain barrier permeability. If the average Tl-201 index is less than the average Tc-99m-DTPA index it suggests that the increased Tl-201 activity results primarily from blood-brain barrier breakdown. Tc-99m-DTPA SPECT, in addition to Tl-201 SPECT, or serial Tl-201 SPECT imaging may increase the accuracy of brain scintigraphy in differentiating radiation necrosis from tumor recurrence. To verify these preliminary findings, we are in the process of analyzing additional SPECT data on 9 more patients with malignant brain tumors. Using a slightly different method of quantifying Tl- 201/Tc-99m-DTPA ratios (computing the ratio of intralesional Tl-201 or Tc-99m-DTPA activity compared to adjacent scalp activity), patients with tumor recurrence have higher Tl-201/Tc-99m-DTPA ratios compared to those with radiation necrosis (verbal communication with Dr. Mary K. Gumerlock). (orig.) [de

  12. Influence of chest background on pulmonary 99m Tc-DTPA clearance in interstitial lung disease

    International Nuclear Information System (INIS)

    Ishizaka, Akitoshi; Kanazawa, Minoru; Suzuki, Yukio; Hasegawa, Naoki; Kubo, Atsushi; Kawashiro, Takeo

    1992-01-01

    The authors examined the effect of chest extracellular 99m T c -diethylenetriamine pentaacetate (DTPA) as a background in the measurement of pulmonary 99m T c -DTPA clearance in patients with interstitial lung disease (ILD). Eight healthy nonsmokers (HN) and eight patients with ILD were studied. They monitored changes in gamma counts after the inhalation of 99m T c -DTPA aerosol by using a gamma camera placed over the anterior chest. The rate constant of pulmonary 99m T c -DTPA clearance (k; %/min) was assessed by calculating the slope of the decrease in the gamma counts. The chest background, estimated by 99m T c -DTPA intravenous injection, was subtracted from the original data to obtain the corrected DTPA clearance (k c ; %/min). In patients with ILD, k was significantly greater [2.19 ± 1.03 (SD) %/min; n = 8] compared with HN (0.86 ± 0.17%/min; n = 8; P c was also greater (2.80 ± 1.15%/min; n = 8; P c among all subjects (r = 0.987, P 99m T c -DTPA clearance. 16 refs., 2 figs., 2 tabs

  13. Tc-99m-DTPA--a new test substance for detoxification devices.

    Science.gov (United States)

    Ahrenholz, P; Falkenhagen, D; Roy, T; Esther, G; Klinkmann, H

    1982-05-01

    Tc99m labeled diethylenetriaminepentaacetic acid (Tc-99m-DTPA) is an appropriate in vivo test solute for all extracorporeal detoxification procedures. The molecular weight of the Tc-99m-DTPA complex is within the biologically relevant middle molecular range of 400 to 700 daltons. Tc-99m-DTPA is distributed in the extracellular space in the same way as inulin. Regarding its localization in the gel filtration spectra and plasma clearance, Tc-99m-DTPA corresponds to middle molecule peak 2. The evaluation of elimination rate and plasma clearance CP of Tc-99m-DTPA is possible by measuring the pulse rates before and after the detoxification device. Taking into account the corrections for Ht and UFR, the Tc-99m-DTPA plasma clearances were calculated for different dialyzers, high flux dialyzers, hemofilters and a hemoperfusion device. The continuous measurement of pulse rates and the use of a UFR-controller (A2008) allow an exact tracking of CP vs. time, the estimation of CP (QB), CP(UFR) and of the sieving coefficient. Examples are given for these cases. It was shown that an increase in plasma clearance to more than about 100 ml/min does not greatly increase the Tc-99m-DTPA elimination rate.

  14. Modeling Temperature and Pricing Weather Derivatives Based on Temperature

    Directory of Open Access Journals (Sweden)

    Birhan Taştan

    2017-01-01

    Full Text Available This study first proposes a temperature model to calculate the temperature indices upon which temperature-based derivatives are written. The model is designed as a mean-reverting process driven by a Levy process to represent jumps and other features of temperature. Temperature indices are mainly measured as deviations from a base temperature, and, hence, the proposed model includes jumps because they may constitute an important part of this deviation for some locations. The estimated value of a temperature index and its distribution in this model apply an inversion formula to the temperature model. Second, this study develops a pricing process over calculated index values, which returns a customized price for temperature-based derivatives considering that temperature has unique effects on every economic entity. This personalized price is also used to reveal the trading behavior of a hypothesized entity in a temperature-based derivative trade with profit maximization as the objective. Thus, this study presents a new method that does not need to evaluate the risk-aversion behavior of any economic entity.

  15. Gd-DTPA-enhanced MR imaging in facial nerve paralysis

    International Nuclear Information System (INIS)

    Tien, R.D.; Dillon, W.P.

    1989-01-01

    GD-DTPA-enhanced MR imaging was used to evaluate 11 patients with facial nerve paralysis (five acute idiopathic facial palsy (Bell palsy), three chronic recurrent facial palsy, one acute facial palsy after local radiation therapy, one chronic facial dyskinesia, and one facial neuroma). In eight of 11 patients, there was marked enhancement of the infratemporal facial nerve from the labyrinthine segment to the stylomastoid foramen. Two patients had additional contrast enhancement in the internal auditory canal segment. In one patient, enhancement persisted (but to a lesser degree) 8 weeks after symptoms had resolved. In one patient, no enhancement was seen 15 months after resolution of Bell palsy. The facial neuroma was seen as a focal nodular enhancement in the mastoid segment of the facial nerve

  16. Evaluation of meningeal enhancement with Gd-DTPA

    International Nuclear Information System (INIS)

    Phillips, M.; Ryals, T.J.; Yuh, W.T.C.; Kambho, S.

    1989-01-01

    Forty-three consecutive patients (16 with tumor, 11 with inflammation, 16 postoperative) with abnormal meningeal enhancement were studied. Positive pathology was obtained in 75% of tumors and 100% of inflammatory conditions. Pial enhancement was demonstrated in seven of 11 patients with inflammation, four of 16 with tumor, and two of 16 postoperative patients. Diffuse meningeal enhancement was most commonly present with neoplastic and inflammatory etiologies. Localized enhancement predominated in the postoperative population, unless complicated by a subdural hematoma. A nodular appearance was present in two patients with tumor. In conclusion, Gd-DTPA MR imaging is sensitive to but not specific of meningeal pathology. MR imaging is better in inflammatory than in neoplastic conditions

  17. DTPA therapy of lung contaminations: testing a self contained aerosol generator

    International Nuclear Information System (INIS)

    Ducousso, R.; Pasquier, C.

    1975-01-01

    It has been shown how much the effectiveness of DTPA therapy of respiratory contamination decreased when the delay of administration of the product increased. Moreover, the effectiveness of local administration of the chelating agent as aerosol has been widely recognized. Owing to both the therapeutic urgency and the local administration, an individual pocket apparatus allowing emergency DTPA inhalation, on the spot of the accident was tried. A turbo-inhalator sold for the administration of an anti-asthmatic powder was tested, using DTPA powder inhaled by a volunteer previously contaminated by a 140 LaCl 3 aerosol [fr

  18. Preparation of {sup 111}In-DTPA morpholino oligomer for low abdominal accumulation

    Energy Technology Data Exchange (ETDEWEB)

    Liu Guozheng, E-mail: guozheng.liu@umassmed.ed [Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655-0243 (United States); Dou Shuping; Rusckowski, Mary [Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655-0243 (United States); Greiner, Dale [Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655-0243 (United States); Hnatowich, Donald [Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655-0243 (United States)

    2010-09-15

    An ability to quantitate the beta cell mass by noninvasive nuclear imaging will be very useful in the prevention, diagnosis, and treatment of diabetes. However, to be successful, radioactivity from the pancreas must not be obscured by the background radioactivity in the abdomen. Pretargeting offers the promise of achieving high target organ to normal tissue ratios. In preparation for pancreas imaging studies by pretargeting using morpholino oligomers (MORF/cMORF), it was necessary to develop a simple and efficient method to radiolabel the cMORF effector. Because we have shown that labeling the cMORF with {sup 111}In via DTPA reduces excretion into the intestines compared to labeling with {sup 99m}Tc via MAG{sub 3}, the conjugation of DTPA to cMORF was investigated for {sup 111}In labeling. The amine-derivatized cMORF was conjugated with DTPA using 1-ethyl-3(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) as an alternative to the conventional cyclic anhydride. The conjugation efficiency (represented by the number of DTPA groups attached per cMORF) was investigated by changing the EDC, DTPA, and cMORF molar ratios. Different open columns were considered for the purification of DTPA-cMORF. Before conjugation, each cMORF molecule was confirmed to have an amine by trinitrobenzene sulfonic acid (TNBS) assay using the {omega}-amino butyric acid as positive standard and the non-amine derivatized cMORF as negative standard. The average number of DTPA groups per cMORF was 0.15-0.20 following the conjugation over a cMORF/DTPA molar ratio of 0.5-5 and over a cMORF/EDC molar ratio of 20-60. The conjugation efficiency was lower than expected probably due to steric hindrance. A 1x50 cm P-4 column using ammonium acetate as eluting buffer provided an adequate separation of DTPA-cMORF from free DTPA. The {sup 111}In labeling efficiency by transchelation from acetate exceeded 95%, thus avoiding the need for postlabeling purification. Despite the lower than expected conjugation

  19. Enhanced conjugation stability and blood circulation time of macromolecular gadolinium-DTPA contrast agent

    Energy Technology Data Exchange (ETDEWEB)

    Jenjob, Ratchapol [Department of New Drug Development, School of Medicine, Inha University, 2F A-dong, Jeongseok Bldg., Sinheung-dong 3-ga, Jung-gu, Incheon 400-712 (Korea, Republic of); Kun, Na [Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743 (Korea, Republic of); Ghee, Jung Yeon [Utah-Inha DDS and Advanced Therapeutics, B-403 Meet-You-All Tower, SongdoTechnopark, 7–50, Songdo-dong, Yeonsu-gu, Incheon 406-840 (Korea, Republic of); Shen, Zheyu; Wu, Xiaoxia [Division of Functional Materials and Nano-Devices, Ningbo Institute of Materials Technology & Engineering (NIMTE), Chinese Academy of Sciences, 519 Zhuangshi Street, Zhenhai District, Ningbo, Zhejiang 315201 (China); Cho, Steve K., E-mail: scho@gist.ac.kr [Division of Liberal Arts and Science, GIST College, Gwangju Institute of Science and Technology, Gwangju 500-712 (Korea, Republic of); Lee, Don Haeng [Utah-Inha DDS and Advanced Therapeutics, B-403 Meet-You-All Tower, SongdoTechnopark, 7–50, Songdo-dong, Yeonsu-gu, Incheon 406-840 (Korea, Republic of); Department of Internal Medicine, School of Medicine, Inha University Hospital, Incheon 420-751 (Korea, Republic of); Yang, Su-Geun, E-mail: Sugeun.Yang@Inha.ac.kr [Department of New Drug Development, School of Medicine, Inha University, 2F A-dong, Jeongseok Bldg., Sinheung-dong 3-ga, Jung-gu, Incheon 400-712 (Korea, Republic of)

    2016-04-01

    In this study, we prepared macromolecular MR T1 contrast agent: pullulan-conjugated Gd diethylene triamine pentaacetate (Gd-DTPA-Pullulan) and estimated residual free Gd{sup 3+}, chelation stability in competition with metal ions, plasma and tissue pharmacokinetics, and abdominal MR contrast on rats. Residual free Gd{sup 3+} in Gd-DTPA-Pullulan was measured using colorimetric spectroscopy. The transmetalation of Gd{sup 3+} incubated with Ca{sup 2+} was performed by using a dialysis membrane (MWCO 100–500 Da) and investigated by ICP-OES. The plasma concentration profiles of Gd-DTPA-Pullulan were estimated after intravenous injection at a dose 0.1 mmol/kg of Gd. The coronal-plane abdominal images of normal rats were observed by MR imaging. The content of free Gd{sup 3+}, the toxic residual form, was less than 0.01%. Chelation stability of Gd-DTPA-Pullulan was estimated, and only 0.2% and 0.00045% of Gd{sup 3+} were released from Gd-DTPA-Pullulan after 2 h incubation with Ca{sup 2+} and Fe{sup 2+}, respectively. Gd-DTPA-Pullulan displayed the extended plasma half-life (t{sub 1/2,α} = 0.43 h, t{sub 1/2,β} = 2.32 h), much longer than 0.11 h and 0.79 h of Gd-EOB-DTPA. Abdominal MR imaging showed Gd-DTPA-Pullulan maintained initial MR contrast for 30 min. The extended plasma half-life of Gd-DTPA-Pullulan probably allows the prolonged MR acquisition time in clinic with enhanced MR contrast. - Highlights: • Macromolecule (pullulan) conjugated Gd contrast agent (Gd-DTPA-Pullulan) showed the extended plasma half-life (t{sub 1/2,α} = 0.43 h, t{sub 1/2,β} = 2.32 h) in comparison with Gd-EOB-DTPA • Gd-DTPA-pullulan T1 contrast agent exhibited strong chelation stability against Gd. • The extended blood circulation attributed the enhanced and prolonged MR contrast on abdominal region of rats. • The extended blood circulation may provide prolonged MR acquisition time window in clinics.

  20. Low-complexity topological derivative-based segmentation.

    Science.gov (United States)

    Cho, Choong Sang; Lee, Sangkeun

    2015-02-01

    Topological derivative has been employed for image segmentation and restoration. The topological derivative-based segmentation uses two sparse matrices, and the computational complexity of the segmentation grows up dramatically as the image size increases due to the size of the sparse matrix. Therefore, to provide a fast and accurate segmentation with low complexity, an effective scheme is proposed with keeping the same segmentation performance. To further reduce the computational complexity, the parallel processing structure for the proposed scheme is designed and implemented on graphics processing unit (GPU). In particular, to reduce the computational cost of generating and multiplying sparse matrices that are squared symmetric, the 2D filters consisting of the coefficients at nonborder regions of sparse matrices are defined, and the multiplication is converted into a convolution filtering. In addition, to design a parallel processing for the segmentation with the proposed scheme on a GPU, an image is divided into several blocks and they are processed in parallel. Experimental results show that the proposed scheme for topological derivative-based segmentation reduces the computational complexity ~ 908 times, and the complexity of the proposed scheme is reduced ~ 17 times more from the parallel structure. In particular, the higher efficiency can be obtained from large sized images because the complexity of the proposed scheme does not depend on the image size. Moreover, the proposed scheme can provide almost identical segmentation result with the original sparse matrix-based approach. Therefore, we believe that the proposed scheme can be a useful tool for efficient topological derivative-based segmentation.

  1. Synthesis and Antiproliferative Activity of Thioxoflavones Mannich Base Derivatives.

    Science.gov (United States)

    Li, Wei; Li, Xueli; Liu, Manhui; Wang, Qiuan

    2017-07-01

    Two series of 12 novel thioxoflavones Mannich base derivatives 5a-f and 6a-f were synthesized via Mannich reaction of 4',7-dimethoxy-5-hydroxyflavothione (3) or 3',4',7-trimethoxy-5-hydroxyflavothione (4) with appropriate aliphatic amines or alicyclic amines and formaldehyde. Thioxoflavones 3 and 4 were prepared from 4',7-dimethoxy-5-hydroxyflavone (1) and 3',4',7-trimethoxy-5-hydroxyflavone (2) with Lawesson's reagent, respectively. Their antiproliferative activities in vitro were evaluated on a panel of three human cell lines (HeLa, HCC1954, and SK-OV-3) by CCK-8 assay. The results showed that most of the thioxoflavones and their Mannich base derivatives exhibited potential antiproliferative activities on the tested cancer cell lines, with IC 50 values ranging from 9.16 to 55.50 μM. In particular, thioxoflavone 4 and the thioxoflavone Mannich base derivatives 5a and 5d showed the best antiproliferative activity on all three human cancer cell lines; they are promising candidates worthy of further development. The structures of all synthesized compounds were confirmed by 1 H NMR, 13 C NMR, IR, and MS techniques. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Monoexponential analysis of plasma disappearance of 99mTc-DTPA and 131I-iodohippurate: A reliable method for measuring changes of renal function

    International Nuclear Information System (INIS)

    Clifton, G.G.; Anderson, C.; McMahon, G.; Vargas, R.; Wallin, J.D.

    1989-01-01

    Glomerular filtration rate and effective renal plasma flow were measured in 170 subjects using monoexponential analysis of plasma disappearance curves for 99m Tc-DTPA and 131 I-iodohippurate after single injection. In the current study population, glomerular filtration rate and effective renal plasma flow decreased with increasing age, were less in females than in males, and were less in hypertensives than in normotensives. Differences in glomerular filtration rate according to age and sex in the current study were similar to those reported using traditional creatinine clearance methodology. Monoexponential treatment of plasma isotope disappearance gave reproducible values for both glomerular filtration rate and effective renal plasma flow when measured either during the day or on a daily basis. Intraindividual coefficient of variation was less than 10% for both 99m Tc-DTPA and 131 I-iodohippurate clearances derived from monoexponential analysis. These results demonstrate that monoexponential analysis of plasma disappearance curves for 99m Tc-DTPA and 131 I-iodohippurate after a single injection is a useful method for evaluating changes in renal hemodynamics either during chronic drug therapy or acutely after single dose administration

  3. Radioisotope power system based on derivative of existing Stirling engine

    International Nuclear Information System (INIS)

    Schock, A.; Or, C.T.; Kumar, V.

    1995-01-01

    In a recent paper, the authors presented the results of a system design study of a 75-watt(c) RSG (Radioisotope Stirling Generator) for possible application to the Pluto Fast Flyby mission. That study was based on a Stirling engine design generated by MTI (Mechanical Technology, Inc.). The MTI design was a derivative of a much larger (13 kwe) engine that they had developed and tested for NASA's LERC. Clearly, such a derivative would be a major extrapolation (downsizing) from what has actually been built and tested. To avoid that, the present paper describes a design for a 75-watt RSG system based on derivatives of a small (11-watt) engine and linear alternator system that has been under development by STC (Stirling Technology Company) for over three years and that has operated successfully for over 15,000 hours as of March 1995. Thus, the STC engines would require much less extrapolation from proven designs. The design employs a heat source consisting of two standard General Purpose Heat Source (GPHS) modules, coupled to four Stirling engines with linear alternators, any three of which could deliver the desired 75-watt(e) output if the fourth should fail. The four engines are coupled to four common radiators with redundant heatpipes for rejecting the engines' waste heat to space. The above engine and radiator redundancies promote system reliability. The paper describes detailed analyses to determine the effect of radiator geometry on system mass and performance, before and after an engine or heatpipe failure

  4. Alteration of renal function in a control animal. Finding by 99mTc - DTPA renogram

    International Nuclear Information System (INIS)

    Portillo, M.G.; Tesán, F.C.; Zubillaga, M.B.; Salgueiro, M.J.

    2015-01-01

    The use of small animal imaging in research protocols allowed the identification of an outlier animal. The renogram with 99m Tc-DTPA showed renal pathology in an animal from the control group. (authors) [es

  5. Decorporation therapy for inhaled plutonium nitrate using repeatedly and continuously administered DTPA

    International Nuclear Information System (INIS)

    Guilmette, R.A.; Muggenburg, B.A.

    1993-01-01

    In this study, dogs inhaled a polydisperse aerosol of 238 Pu(NO 3 ) 4 and were treated with a single initial injection of CaDTPA (30 μmol kg -1 ) followed by either repeated intravenous injections of ZnDTPA (30 μmol kg -1 injection) or subcutaneous infusion of ZnDTPA (30 or 120 μmol kg -1 day -1 ). Each treatment regimen commenced at 1 h after exposure and continued throughout 64 days. Unlike the results of previous studies with Am and Cm, in which the actinide dissolved in vivo over periods of many days to weeks, no significant differences in decorporation efficiency of 238 Pu were noted for the three different DTPA-treated groups. All treatments removed about 85% of the initial pulmonary burden (IPB) of 238 Pu compared with 24% IPB excreted by the saline-treated control dogs. (Author)

  6. The labeling of DTPA-coupled proteins with sup(99m)Tc

    International Nuclear Information System (INIS)

    Lanteigne, D.; Hnatowich, D.J.

    1984-01-01

    We have determined that reduced sup(99m)Tc will often bind to proteins even in the presence of DTPA at reasonable concentrations. The extent of this competition varies with the protein but many possess this property. We have shown that, despite this competition, DTPA-coupled proteins can be labeled with sup(99m)Tc and that this labeling can be achieved at near-neutral pH using stannous ion for reduction. Both lysosyme and IgG antibody were labeled with sup(99m)Tc after coupling with DTPA and their biodistributions determined at 1-2 h in mice along with the 111 In-labeled proteins as controls. The results of these animal studies show that the proteins are largely labeled at the DTPA sites and that they exhibit in vivo stabilities comparable to that of the 111 In labeled proteins. (author)

  7. Paramagnetic Gd IIIFe III heterobimetallic complexes of DTPA-bis-salicylamide

    Science.gov (United States)

    Aime, S.; Botta, M.; Fasano, M.; Terreno, E.

    1993-08-01

    The reaction between DTPA (diethylenetriaminepenta-acetic acid)-anhydride and p-aminosalicylic acid (PAS) affords a novel ligand, [DTPA(PAS) 2], able to form stable heterobimetallic complexes with Gd 3+ and Fe 3+ ions. The lanthanide ion occupies an internal coordination cage formed by three nitrogen atoms, two carboxylate and two carboxoamido groups of the ligand, whereas the outer salicylic moieties form stable chelate rings with Fe III ions. The stoichiometry of the resulting heterobimetallic complexes, established by measurements of water proton relaxation enhancement, is [(H 2O)-Gd-DTPA(PAS) 2] 2-Fe(H 2O) 2 or [(H 2O)-Gd-DTPA(PAS) 2] 3-Fe depending on the pH of the aqueous solution. The individual contributions to the observed relaxation enhancement from Gd 3+ and Fe 3+ paramagnetic ions have been clearly distinguished and analysed.

  8. Gadolinium-DTPA enhanced MRI with CHESS method for lumbar disc herniation

    International Nuclear Information System (INIS)

    Aota, Yoichi; Kumano, Kiyoshi; Hirabayashi, Shigeru; Ogawa, Yutaka; Yoshikawa, Koki

    1993-01-01

    A total of 34 DTPA-enhanced magnetic resonance imaging (MRI) studies were made pre- and/or post-operatively by using chemical shift selective method in 31 patients with lumbar disc herniation. DTPA enhancement was seen in affected nerve roots in 7 of 15 preoperative cases and 6 of 12 postoperative cases with unfavorable course. When straight leg raising test revealed severe stimulation to the lower extremity nerve roots (less than 45degree), affected nerve roots were significantly enhanced with DTPA. All enhanced sites, except for one of arachnoid inflammation, was most remarkably compressed by herniation. Edema within the affected nerve root would be detected by DTPA-enhanced MRI. (N.K.)

  9. Radioisotopic investigation of renal arterial hypertension using 99m Tc-DTPA

    International Nuclear Information System (INIS)

    Champailler, A.; Defour-Decousus, M.; Houzard, C.; Healy, J.C.; Gonthier, R.; Juge, J.; Berthoux, F.C.

    1984-01-01

    To evaluate the clinical validity of renal investigation using 99m Tc-DTPA, 60 hypertensive patients divided into four groups according to diagnosis were studied: 1) renovascular hypertension (22 patients); 2) chronic pyelo-nephritis (11 patients); 3) renal hypoplasia (12 patients); 4) hypertension due to bilateral parenchymatous (15 patients). A good correlation was found between clearance of DTPA and creatinine clearance/1.73 m 2 body surface (n = 51, r = 0.68, p 2 BS [fr

  10. Study with radio aerosol of DTPA technetium-99 m in individuals with pulmonary disease by amiodarone

    International Nuclear Information System (INIS)

    Terra Filho, M.

    1989-01-01

    In order to evaluate the role of the clearance of 99 m Technetium chelated to diethylenetriamine-penta-acetate (99 m Tc-DTPA) in amiodarone induced pulmonary disease, 40 individuals were studied in four groups. After spirometry, where a volume-time curve was registered, all individuals inhaled 740 MBq of 99 m Tc-DTPA diluted in 4 ml of saline, for five minutes. Pulmonary images were obtained in a computerized scintillation camera and 9 regions of interest were selected. (author)

  11. Synthesis, characterization and biological evaluation of tryptamine based benzamide derivatives.

    Science.gov (United States)

    Aftab, Kiran; Aslam, Kinza; Kousar, Shazia; Nadeem, Muhammad Jawad Ul Hasan

    2016-03-01

    Benzamides and tryptamine are biologically significant compounds, therefore, various benzamide analogous of tryptamine have been efficiently synthesized using tryptamine and different benzoyl chlorides, in order to find new biologically active compounds. The resulting products were then characterized by melting point determination, calculation of Rf values and LC-MS techniques. At last, structure activity relationship (SAR) of the synthesized compounds was evaluated against two microbial strains; Bacillus subtilis and Aspergillus niger. All the five prepared products have shown high yield, sharp characterization and significant resistance against the growth of tested microorganism, providing a new range of tryptamine based benzamide derivatives having significant antimicrobial activities.

  12. Design and functionalities of the MADORR software suite for dose-reduction management after DTPA therapy

    International Nuclear Information System (INIS)

    Leprince, B.; Fritsch, P.; Romeo, P.H.; Berard, P.

    2016-01-01

    A software suite on biokinetics of radionuclides and internal dosimetry intended for the occupational health practitioners of nuclear industry and for expert opinions has been developed under Borland C++ Builder TM . These computing tools allow physicians to improve the dosimetric follow-up of workers in agreement with the French regulations and to manage new internal contaminations by radionuclides such as Pu and/or Am after diethylene triamine penta-acetic acid treatments. In this paper, the concept and functionalities of the first two computing tools of this MADOR R suite are described. The release 0.0 is the forensic application, which allows calculating the derived recording levels for intake by inhalation or ingestion of the main radioisotopes encountered in occupational environment. Indeed, these reference values of activity are convenient to interpret rapidly the bioassay measurements and make decisions as part of medical monitoring. The release 1.0 addresses the effect of DTPA treatments on Pu/Am biokinetics and the dose benefit. The forensic results of the MADOR R suite were validated by comparison with reference data. (authors)

  13. MR imaging of the breast with Gd-DTPA enhancement

    International Nuclear Information System (INIS)

    Hachiya, Junichi; Seki, Tsuneaki; Okada, Minoru; Nitatori, Toshiaki; Korenaga, Tateo; Furuya, Yoshiro

    1991-01-01

    The accuracy of MR imaging with Gd-DTPA enhancement was compared with mammography and ultrasonography in 52 patients with clinically palpable benign and malignant breast masses (36 carcinomas, 2 malignant phyllodes tumors, 7 fibroadenomas, 7 cysts). On dynamic MR imaging, carcinomas and fibroadenomas were discriminated by their different dynamic enhancement profiles. In carcinomas, signal intensity increased rapidly, reaching a peak or plateau within 2 min after the injection of contrast medium. In fibroadenomas, signal intensity showed a much slower continuous increase without ceasing until about 8 min after injection. Malignant phyllodes tumors showed a dynamic enhancement profile identical to that of benign fibroadenomas. MR imaging correctly identified 84% of malignant tumors, 86% of fibroadenomas, and 100% of cysts, and was substantially more accurate in tissue characterization than mammography. The results of ultrasonography were highly similar to those of MR imaging. However, no single modality was infallible, and the three modalities were complementary rather than competitive. Considering the high cost and long examination time of MR imaging, mammography supplemented by ultrasonography seems to be the method of choice in the diagnosis of breast lesions. Nevertheless, MR imaging can add important information when the results of mammography and ultrasonography are insufficient or contradictory. (author)

  14. Gd-DTPA enhanced MR imaging in Bell's palsy

    International Nuclear Information System (INIS)

    Matsumoto, Yasushi; Kawamura, Yuji; Yanagihara, Naoaki; Sadamoto, Masanori; Sadamoto, Kazuhiko.

    1991-01-01

    Magnetic resonance imaging (MRI) was carried out in 27 patients with Bell's palsy. T1-weighted spin-echo images (TR500/TE25-34) were taken before and after the intravenous administration of Gd-DTPA (0.1 mmol/kg) with 0.5T superconductive MRI. There was significant enhancement at the geniculate ganglion and the horizontal segment of the involved facial nerve in 22 patients (81.5%) and at the vertical segment in 20 (74.1%). Enhancement at the meatal fundus was seen in only 4 patients (14.9%) and at the labyrinthine segment in 8 (29.6%). These results corroborate other evidence that the geniculate ganglion is involved most frequently in Bell's palsy. In addition, the enhancement of the proximal portion, i.e. the meatal fundus and the labyrinthine segment of the nerve, although not common, noted in this study may be important in the diagnosis and treatment of Bell's palsy. (author)

  15. MRI of spondylodiscities: contribution of gadolinium-DTPA and fat suppression sequence

    Energy Technology Data Exchange (ETDEWEB)

    Cova, M.A. [Dept. of Radiology, Univ. of Trieste, Cattinara Hospital (Italy); Dalla Palma, L. [Dept. of Radiology, Univ. of Trieste, Cattinara Hospital (Italy); Pozzi-Mucelli, R.S. [Dept. of Radiology, Univ. of Trieste, Cattinara Hospital (Italy); Ricci, C. [Dept. of Radiology, Univ. of Trieste, Cattinara Hospital (Italy)

    1993-12-01

    Twenty-six patients with a clinical diagnosis of spondylodiscitis were examined with non-contrast and contrast-enhanced MRI in order to define the contribution of gadolinium-DTPA (Gd-DTPA) and different pulse sequences, including a fat suppression sequence (SPIR). Spin echo (SE) T1-weighted images before and after Gd-DTPA injection and SE T2-weighted images were obtained in all patients. Twelve patients were also examined using the SPIR sequence following Gd-DTPA injection. Signal intensity and morphological features of the disc and vertebral lesions were then evaluated. The SE T1-weighted sequence with Gd-DTPA was very effective in showing the pathological changes at the level of the disc as an area of low signal intensity surrounded by a peripheral rim of enhancement in 24 of 26 cases (92%). This feature was not visible on non-enhanced images. As regards contiguous vertebral lesions this sequence was less informative, since in 8 of 26 cases (31%) the vertebral lesions became isointense and therefore not detectable. In 12 cases there was extension into the surrounding structures (spinal canal and/or paravertebral tissues). An enhanced SE T1-weighted sequence provided good anatomical definition of the extension of the infection in the spinal canal in all cases with this type of involvement (7 of 12). Regarding the 7 cases with paravertebral extension, no extension was visible in 1 case due to the reduced contrast with the surrounding fat following Gd-DTPA injection. The enhanced SPIR sequence was very effective, particularly in detecting the lesions in the vertebral bodies, avoiding the limitation of the enhanced SE T1-weighted sequence. The SPIR sequence was also effective in showing the extension within the spinal canal and the paravertebral fat. On the basis of our results the combination of a SE T1-weighted sequence without contrast and SPIR sequence with Gd-DTPA seems to be the best approach in cases of spondylodiscitis. (orig.)

  16. Gd-EOB-DTPA-enhanced magnetic resonance imaging for bile duct intraductal papillary mucinous neoplasms

    Science.gov (United States)

    Ying, Shi-Hong; Teng, Xiao-Dong; Wang, Zhao-Ming; Wang, Qi-Dong; Zhao, Yi-Lei; Chen, Feng; Xiao, Wen-Bo

    2015-01-01

    AIM: To investigate gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) of intraductal papillary mucinous neoplasms of the bile duct (IPMN-B). METHODS: The imaging findings of five cases of IPMN-B which were pathologically confirmed at our hospital between March 2012 and May 2013 were retrospectively analyzed. Three of these cases were diagnosed by duodenal endoscopy and biopsy pathology, and two cases were diagnosed by surgical pathology. All five patients underwent enhanced and non-enhanced computed tomography (CT), magnetic resonance cholangiopancreatography, and Gd-EOB-DTPA-enhanced MRI; one case underwent both Gd-EOB-DTPA-enhanced MRI and positron emission tomography-CT. The clinical data and imaging results for these cases were compared and are presented. RESULTS: Conventional imaging showed diffuse dilatation of bile ducts and multiple intraductal polypoid and papillary neoplasms or serrated changes along the bile ducts. In two cases, Gd-EOB-DTPA-enhanced MRI revealed dilated biliary ducts and intraductal tumors, as well as filling defects caused by mucin in the dilated bile ducts in the hepatobiliary phase. Gd-EOB-DTPA-enhanced MRI in one case clearly showed a low-signal tumor in the hepatobiliary phase, similar to what was seen by positron emission tomography-CT. In two patients, routine inspection was unable to discern whether the lesions were inflammation or tumors. However, Gd-EOB-DTPA-enhanced MRI revealed a pattern of gradual enhancement during the hepatobiliary phase, and the signal intensity of the lesions was lower than the surrounding liver parenchyma, suggesting tissue inflammation in both cases, which were confirmed by surgical pathology. CONCLUSION: Gd-EOB-DTPA-enhanced MRI reveals the intraductal mucin component of IPMN-B in some cases and the extent of tumor infiltration beyond the bile ducts in invasive cases. PMID:26167082

  17. Pre-targeted tumor imaging with avidin-McAb and 99Tcm-DTPA-Biotin

    International Nuclear Information System (INIS)

    Zhang Jinming; Tian Jiahe; Wang Yuqi; Liu Xi; Sun Xin

    2002-01-01

    Objective: Biotin-avidin is used as pre-targeting system (BAS) in radioimmunoimaging in order to decrease radiation background and dose associated with the use of directly labelled McAb. The authors tried to use 99 Tc m to substitute 111 In to label DTPA-biotin to evaluate the value of the 99 Tc m -DTPA-biotin in BAS. Methods: DTPA-biotin solution was mixed with SnCl 2 and then fresh eluted 99 Tc m . The solution incubated for 10 min at room temperature. Mice bearing lung tumor (LA-795) with and without metastases in lung underwent 3-step pre-targeting test. Briefly, biotin-C50 was injected first, then avidin and 99 Tc m -DTPA-biotin was respectively given 1 day, 2 days later. Directly labelled C50 with 99 Tc m was used as control agent. Results: The labelling yield of 99 Tc m -DTPA-biotin was over 90%. The amount of SnCl 2 was the key feature in labelling. The tumor could be seen at 2 h after injection of 99 Tc m -DTPA-biotin with γ camera in 3- step groups. The tracer uptake in tumor was (1.35 +- 0.45)% ID/g at 2 h after injection, Tumor/Blood (T/B) was 5.86, T/Muscle (T/M) was 8.43. In control group which received 99 Tc m -DTPA-biotin only, the T/B was 0.85, T/M 1.1. For the directly labelled C50, the T/B was 1.65, T/M was 2.0 at 8 h after injection. Conclusion: Avidin-biotin pre-targeting system can be labelled with 99 Tc m , and the BAS can image the tumor as early as 2 h after injection

  18. Microscopic derivation of particle-based coarse-grained dynamics

    Science.gov (United States)

    Izvekov, Sergei

    2013-04-01

    In this paper we revisit the derivation of equations of motion for coarse-grained (CG) particles from the microscopic Hamiltonian dynamics of the underlying atomistic system in equilibrium. The derivation is based on the projection operator method and time-convolution equation. We demonstrate that due to the energy exchange between CG and intraparticle phase space coordinates in the microscopic system, the choice of projection operator is not unique, leading to different CG equations of motion that have the form of the nonlinear generalized Langevin equation (GLE). We derive the idempotence properties for the projection operators along the system trajectories and show that these properties result in streaming terms of the respective GLEs that are conservative forces and allow the expression of the non-conservative forces explicitly through thermodynamic averages, which can be measured from the microscopic simulations. The difference between GLEs that are presented herein lies in how the non-conservative forces are partitioned into dissipative and projected contributions. We compute the projected force and analyze conditions under which the projected (stochastic) force is orthogonal to (uncorrelated with) the momenta of CG particles, therefore justifying a transition to a framework of stochastic differential equations. We show that a position- and momentum-independent memory function appears only if the projected force is fully decoupled from the past CG positions and momenta, respectively. In the case of non-vanishing correlations between the projected force and the CG coordinates in past times, we derive explicitly the position- and momentum-dependent memory function in a form of projection onto a space spanned by N-order Hermite polynomials. The expressions presented herein can be used to construct a hierarchy of thermodynamically consistent CG models with momentum-dependent memory functions. They can also be used to design computational schemes for obtaining the

  19. Bile duct evaluation of potential living liver donors with Gd-EOB-DTPA enhanced MR cholangiography: Single-dose, double dose or half-dose contrast enhanced imaging

    International Nuclear Information System (INIS)

    Kinner, Sonja; Steinweg, Verena; Maderwald, Stefan; Radtke, Arnold; Sotiropoulos, Georgios; Forsting, Michael; Schroeder, Tobias

    2014-01-01

    Introduction: Detailed knowledge of the biliary anatomy is essential to avoid complications in living donor liver transplantation. The aim of this study was to determine the optimal dosage of Gd-EOB-DTPA for contrast-enhanced magnetic resonance cholangiography (ce-MRC) with reference to contrast-enhanced CT cholangiography (ce-CTC). Materials and methods: 30 potential living liver donors (PLLD) underwent both ce-CTC and ce-MRC. Ten candidates each received single, double or half-dose Gd-EOB-DTPA. Ce-MRC images with and without inversion recovery pulses (T1w ± IR) were acquired 20–30 min after intravenous contrast injection. Image data was quantitatively and qualitatively reviewed by two radiologists based on a on a 5-point scale. Data sets were compared using a Mann–Whitney-U-test or Wilcoxon-rank-sum-test. Kappa values were also calculated. Results: All image series provided sufficient diagnostic information both showing normal biliary anatomy and variant bile ducts. Ce-CTC showed statistically significant better results compared to all ce-MRC data sets. T1w MRC with single dose Gd-EOB-DTPA proved to be superior to half and double dose in subjective and objective evaluation without a statistically significant difference. Conclusions: Ce-MRC is at any dosage inferior to ce-CTC. As far as preoperative planning of bile duct surgery is focused on the central biliary anatomy, ce-MRC can replace harmful ce-CTC strategies, anyway. Best results were seen with single dose GD-EOB-DTPA on T1w MRC+IR

  20. Evaluation of {sup 90}Y-DTPA and {sup 90}Y-DOTA for potential application in intra-vascular radionuclide therapy

    Energy Technology Data Exchange (ETDEWEB)

    Pandey, Usha; Mukherjee, Archana; Sarma, H.D.; Das, Tapas; Pillai, M.R.A.; Venkatesh, Meera. E-mail: meerav@apsara.barc.ernet.in

    2002-09-01

    {sup 90}Y-1,4,7,10-tetraazacyclododecane tetraacetic acid ({sup 90}Y-DOTA) and {sup 90}Y-diethylene triamine pentaacetic acid ({sup 90}Y-DTPA) complexes were studied for possible use in intra-vascular radionuclide therapy (IVRNT). {sup 90}Y was obtained from a {sup 90}Sr-{sup 90}Y generator based on supported liquid membrane technique. The {sup 90}Y-DOTA and {sup 90}Y-DTPA complexes were prepared under optimised conditions. Bio-distribution of the complexes in Swiss mice showed that nearly 90% of {sup 90}Y complexes of both the ligands were excreted via urine within 1 h post-injection with negligible localisation in vital organs. Probenecid inhibition studies showed that both complexes are excreted by glomerular filtration. The predominant and quick excretion of {sup 90}Y-DOTA and {sup 90}Y-DTPA through the kidneys suggest that both these complexes could be explored for use in IVRNT.

  1. Quantification of gadolinium-DTPA concentrations for different inversion times using an IR-turbo flash pulse sequence: a study on optimizing multislice perfusion imaging

    DEFF Research Database (Denmark)

    Fritz-Hansen, T; Rostrup, Egill; Ring, P B

    1998-01-01

    The purpose of this study was to optimize an inversion-recovery (IR) turbo fast low-angle shot (FLASH) for multislice imaging by evaluating the accuracy of calculated the relaxation-rate (R1) for different inversion times (TI). This is important for tracer kinetic modeling because it requires...... a system responding linearly to input. R1 are linearly related to changes in the concentration of gadolinium (Gd)-diethylenetriaminepentaacetic acid (DTPA), and R1 is a parameter that can be derived from the magnetic resonance (MR) signal. The accuracy of calculated R1 using an IR turbo fast low-angle shot...

  2. Synthesis and evaluation of novel polysaccharide-Gd-DTPA compounds as contrast agent for MRI

    Science.gov (United States)

    Sun, Guoying; Feng, Jianghua; Jing, Fengying; Pei, Fengkui; Liu, Maili

    2003-09-01

    Macromolecular conjugates of two kinds of natural polysaccharides, that from Panax quinquefolium linn (PQPS) and Ganoderma applanatum pat (GAPS), with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) have been synthesized and characterized by means of FTIR, elementary analysis and ICP-AES. Their stability was investigated by competition study with Ca 2+, EDTA (ethylenediaminetetraacetic acid) and DTPA. Polysaccharide-bound complexes exhibit T1 relaxivities of 1.5-1.7 times that of Gd-DTPA in D 2O at 25°C and 9.4 T. MR imaging of Sprague-Dawley (SD) rats showed remarkable enhancement in rat liver and kidney after i.v. injection of these two complexes: liver parenchyma 60.9±5.6%, 57.8±7.4% at 65-85 min; kidney 144.9±14.5%, 199.9±25.4% at 10-30 min for PQPS-Gd-DTPA, GAPS-Gd-DTPA at gadolinium dose of 0.083 and 0.082 mmol/kg, respectively. Our preliminary in vivo and in vitro study indicates that the two kinds of polysaccharide-bound complexes are potential tissue-specific contrast agents for MRI.

  3. Sidestream smoke inhalation decreases respiratory clearance of 99mTc-DTPA acutely

    International Nuclear Information System (INIS)

    Yates, D.H.; Havill, K.; Thompson, M.M.; Rittano, A.B.; Chu, J.; Glanville, A.R.

    1996-01-01

    The permeability of the alveolar-capillary barrier to an inhaled aerosol of technetium 99m labelled diethylenetriamine penta-acetate ( 99m Tc-DTPA is used as an index of alveolar epithelial injury. Permeability is greatly increased in active smokers. The aim of this study was to determine the effect of sidestream smoke inhalation on permeability as this has not been described previously. Lung clearance of inhaled 99m Tc-DTPA aerosol was measured in 20 normal non-smoking subjects before and after exposure to one hours sidestream smoke inhalation. Measured carbon monoxide (CO) levels rose to a maximum of 23.5 ±6.2 ppm from baseline values of 0.6±1.3 (p 99m Tc-DTPA clearance rose from baseline 69.1± 15.6 (mean ± to 77.4 ±17.8) after smoke exposure. No effect of 99m Tc-DTPA scanning of sidestream smoke was demonstrated on lung function. It was concluded that low level sidestream smoke inhalation decreases 99m Tc-DTPA clearance acutely in humans. The mechanism of this unexpected result is not established but may include differences in constituents between sidestream and mainstream smoke, alterations in pulmonary microvascular blood flow, or changes in surfactant due to an acute phase irritant response. 34 refs., 2 figs

  4. Design of (99m) Tc-DTPA-CLP and preliminary evaluation in rats.

    Science.gov (United States)

    Altıparmak, Burcu; Lambrecht, Fatma Y; Er, Ozge

    2014-03-01

    Radiopharmaceuticals are localized in (malignant) tumor tissues by different mechanisms. One of these mechanisms, gelatinase enzyme activity, is associated with poor prognosis in cancer patients and potential targets for tumor imaging. There are some gelatinases to be associated with metastatic potential for tumor imaging to possibly predict metastases. In this study, a cyclic decapeptide conjugate, DTPA-CLP (DTPA-Cys-Leu-Pro-Gly-His-Trp-Gly-Phe-Pro-Ser-Cys), was selected as a peptide conjugate because of its selective inhibitory activity toward gelatinases. Peptide-conjugated DTPA-CLP was labeled with (99m) Tc with a radiolabeling efficiency of 97.0 ± 2.8%. After determining optimization conditions for radiolabeling, a biodistribution study of radiolabeled peptide in albino Wistar rats was performed. According to biodistribution data, (99m) Tc-DTPA-CLP showed high uptake in the lung, liver, uterus, and spleen. These results show that (99m) Tc-DTPA-CLP may be used for the imaging of gelatinase activity in metastatic tumors. © 2013 John Wiley & Sons A/S.

  5. Effectiveness of DTPA Chelate on Cd Availability in Soils Treated with Sewage Sludge

    Directory of Open Access Journals (Sweden)

    Pegah Houshyar

    2017-09-01

    Full Text Available Application of sewage sludge as a fertilizer on farmlands is a common practice in most countries. Although the practice may play a positive role in plant performance, the organic amendments introduced may increase the soil heavy metals content. This study was conducted in Arak, Iran, to investigate the effectiveness of DTPA chelate on corn Cd availability in a sewage sludge treated soil. The treatments consisted of sewage sludge (0, 15, and 30 t ha-1 polluted with cadmium applied at 0, 5, 10, and 15 mg kg-1 as well as DTPA applied at 0 and 1.5 mmol kg-1 soil. Corn plants were then grown in the soil in each treatmnent and, on day 60, the physic-chemical characteristics and Cd quantities were measured ion both the corn plants and soil samples. Application of 1.5 m mol of DTPA chelate in soil contaminated with 5 mg Cd led to a significant increase in the soil available Cd content. It was also observed that application of DTPA chelate to soils containing 30 t ha-1 of sewage sludge polluted with 10 mg Cd increased root and shoot Cd concentrations by 17 and 25%, respectively. Results indicated the effectiveness of DTPA chelate in reducing Cd phytoremediation with increasing sewage sludge loading rate. This was evidenced by the lowest phytoremediation effectiveness observed for the treatment with the greatest sewage sludge loading (30 t ha-1 and the lowest cadmium pollution (5 mg Cd.

  6. MR imaging of the central nervous system in infants and children with Gd-DTPA

    International Nuclear Information System (INIS)

    Baierl, P.; Bauer, W.M.; Forster, C.; Haustein, J.

    1988-01-01

    Twenty-five infants and children (aged 2 - 12 years) were examined with MR imaging at 1.0 T. Most of them were younger than 6 years, and general anesthesia was required for the recording of the images. Gd-DTPA was given in doses of 0.1 mmol/kg (Schering). The native MR images were followed by short flip-angle sequences (fast low-angle shot [FLASH] during the flow of Gd-DTPA. After that, T1-weighted images demonstrated contrast enhancement best. No severe adverse effects were seen. The sensitivity of plain MR imaging could not be improved by Gd-DTPA, but contrast enhancement of a lesion proved to be important for the differential diagnosis

  7. Gd-DTPA-enhanced MR imaging of avascular necrosis of the hip

    International Nuclear Information System (INIS)

    Van de Berg, B.; Malghem, J.; Noel, H.; Maldague, B.

    1990-01-01

    This paper evaluates the interest of Gd-DTPA-enhanced MR imaging in the diagnosis of avascular necrosis (AVN) of the hip. MR imaging of 10 patients with various stages of AVN of the femoral head (14 abnormal hips) was performed (1.5-T Gyroscan). T1-weighted images before and after contrast injection and T2-weighted images were obtained in two planes. MR images were compared with pathologic findings in six femoral head specimens (total hip replacement). In the early stages of AVN (Mitchell classes A and B), a peripheral band of contrast-enhanced tissue appears on T1-weighted images after Gd-DTPA injection, mimicking the double line seen on T2-weighted images. In later stages (class C and D), the sequestrated segments, appearing hypointense on T1-weighted images, usually show a significant signal intensity enhancement after Gd-DTPA injection. The truly avascular areas may be limited to a band of thickened subchondral bone

  8. INSURANCE CONTRACTS BASED ON INDICES, A STEP TOWARDS WEATHER DERIVATIVES

    Directory of Open Access Journals (Sweden)

    Boton#537; Horia-Mircea

    2012-07-01

    Full Text Available The aim of this paper is to analyze the methodology of structuring an index based insurance contract. The weather has always been the biggest risk factor in agriculture, affecting all aspects of the economic sectors. In the developed countries of the world, there is a significant number of rain-dependent farmers. To gain insight into potential growth of weather markets in developed countries, we are going to analyze the case of India. In 2003, Basix microfinance company in Hyderabad and ICICI Lombard insurance company in Mumbai have launched a pilot weather insurance, which had as basic index phenomena for Mahahbubnagar district of Andhra Pradesh. Further detail can be found in the full-paper. In the paper we will enumerate the appropriate steps in the determining the necessity for the use of index based insurances. The appropriate stages are making a comparison between index based insurances and traditional insurances, and optimizing the use of weather indices in insurance contracts. In order for the contracts to be successful , the recommended steps are : developing a product based in an index, and after the we need to plan and implement the contract. In planning the implementation it is needed that we: identify the risks and areas where they manifest, then identify the best distribution channels; after this we can develop a prototype of the contract. The next step would the testing of the negotiability of the contract, then the contract is opened to be finalized. After this the index based insurance contract can be introduced to the market, but the program needs monitoring in order to insure its successfulness. In order for the market and contract to grow the necessary step are: having access to the necessary meteorological data, determine the optimal way of integrating the contract in the existing economical context, technical feasibility, property rights and the legal framework. In the end, the aim is to familiarize the literacy field and

  9. Correlation between choline level and Gd-DTPA enhancement in patients with brain metastases of mammary carcinoma

    NARCIS (Netherlands)

    P.E. Sijens (Paul); P. van Dijk (Pieter); M. Oudkerk (Matthijs)

    1994-01-01

    textabstractSingle voxel 1HH double spin-echo MR spectroscopy was used to examine 15 cases of brain metastasis of mammary carcinoma (18 lesions) in relation to Gd-DTPA enhanced MR imaging. For lesions larger than 50% of MRS voxel size, there was significant correlation between Gd-DTPA-enhanced MRI

  10. The primary applications of Gd-DTPA as an oral negative gastrointestinal contrast agent for MRCP

    International Nuclear Information System (INIS)

    Chen Yanping; Zhang Xuelin; Cheng Guanxun; Chang Renmin; Zhang Yuzhong; Cang Peng; Xia Qiong

    2003-01-01

    Objective: Using oral Gd-DTPA as a negative contrast agent to null the bowel signal during MR cholangiopancreatography (MRCP) to improve the quality of MRCP. Methods: A phantom study was performed to select the optimal concentration of Gd-DTPA to be used as an oral negative contrast agent in MRCP. 15 patients suspected of biliary tract and pancreatic disease were performed with MRCP before and after using 250 ml oral contrast agents (1:5 diluted Gd-DTPA, 1.488 g/L). All MR images were acquired using a 1.5 T whole body MR scanner (Vision Plus, Siemens). MRCP was acquired using two-dimensional single slice fast spin-echo sequence and HASTE (half-fourier acquisition single-shot fast spin echo) sequence. Results: The phantom study showed that the dilution ratio 1:5 of Gd-DTPA oral contrast agent was best in decreasing the signal intensity both in T 2 WI (59.3%) and in HASTE sequence (82.45%). All the dilution ratio of Gd-DTPA oral contrast agent decreased the signal intensity up to 90% on single slice MRCP. In all the patients the high signal intensity from the stomach and intestinal fluid was completely suppressed. The depictions of common bile duct and pancreatic duct were markedly improved by the oral contrast agent (P<0.05). Conclusion: 1:5 diluted (1.488 g/L) oral MR contrast agent Gd-DTPA can be an effective and safe negative contrast agent in eliminating signal intensity of the gastrointestinal tract, thus improving the depiction of the biliary system in MRCP

  11. Enhanced decorporation of plutonium by DTPA encapsulated in small PEG-coated liposomes.

    Science.gov (United States)

    Phan, G; Le Gall, B; Grillon, G; Rouit, E; Fouillit, M; Benech, H; Fattal, E; Deverre, J-R

    2006-11-01

    The aim of the study was to demonstrate that decorporation of 238Pu is achieved more efficiently by an optimized liposomal formulation of diethylene triamine pentaacetic acid (DTPA) than by the usual free DTPA treatment. The optimized formulation consisted of polyethylene glycol-coated stealth liposomes with a mean diameter of 100 nm (SL-100 nm). Rats were intravenously injected with various Pu-phytate salt solutions in order to test different contamination conditions (activity and salt concentration) impacting liver kinetics and skeletal uptake of Pu. All treatments were given intravenously 1 h after contamination. Efficiency was evaluated 24 h, 7, 16 or 30 days later through their ability to promote Pu elimination and to reduce Pu burden in the skeleton and liver, the main organs of Pu deposition and radiotoxicological effects. Whatever the conditions of contaminations, a single injection of SL-100 nm (3.2 micromol kg(-1) DTPA) boosted urinary elimination of Pu to above 90% of the injected dose. In addition, liposomes strongly and significantly reduced the Pu burden of the liver and skeleton even 30 days after a single treatment: a dose of 0.3 micromol kg(-1) induced the same skeletal Pu reduction as four injections of free DTPA (30 micromol kg(-1)). A log dose-effect relation was found with SL-100 nm DTPA and Pu excretion in urine or Pu burden in the studied organs (liver, femurs, spleen and kidneys). This efficacy was attributed to an optimized targeting of DTPA to the main Pu retention organs and especially the liver.

  12. Radar-Derived Quantitative Precipitation Estimation Based on Precipitation Classification

    Directory of Open Access Journals (Sweden)

    Lili Yang

    2016-01-01

    Full Text Available A method for improving radar-derived quantitative precipitation estimation is proposed. Tropical vertical profiles of reflectivity (VPRs are first determined from multiple VPRs. Upon identifying a tropical VPR, the event can be further classified as either tropical-stratiform or tropical-convective rainfall by a fuzzy logic (FL algorithm. Based on the precipitation-type fields, the reflectivity values are converted into rainfall rate using a Z-R relationship. In order to evaluate the performance of this rainfall classification scheme, three experiments were conducted using three months of data and two study cases. In Experiment I, the Weather Surveillance Radar-1988 Doppler (WSR-88D default Z-R relationship was applied. In Experiment II, the precipitation regime was separated into convective and stratiform rainfall using the FL algorithm, and corresponding Z-R relationships were used. In Experiment III, the precipitation regime was separated into convective, stratiform, and tropical rainfall, and the corresponding Z-R relationships were applied. The results show that the rainfall rates obtained from all three experiments match closely with the gauge observations, although Experiment II could solve the underestimation, when compared to Experiment I. Experiment III significantly reduced this underestimation and generated the most accurate radar estimates of rain rate among the three experiments.

  13. A Derivative Based Estimator for Semiparametric Index Models

    NARCIS (Netherlands)

    Donkers, A.C.D.; Schafgans, M.

    2003-01-01

    This paper proposes a semiparametric estimator for single- and multiple index models.It provides an extension of the average derivative estimator to the multiple index model setting.The estimator uses the average of the outer product of derivatives and is shown to be root-N consistent and

  14. Design of photocontrolled biomolecules based on azobenzene derivatives

    Science.gov (United States)

    Zatsepin, T. S.; Abrosimova, L. A.; Monakhova, M. V.; Thi Hien, Le; Pingoud, A.; Kubareva, E. A.; Oretskaya, T. S.

    2013-10-01

    This review focuses on methods of designing photocontrolled proteins and nucleic acids. Data on preparation and modification of proteins and nucleic acids with azobenzene derivatives are summarized. Examples of using photoswitchable proteins, their substrates, inhibitors and ligands containing azobenzene, as well as azobenzene derivatives of nucleic acids, for design of nanomachines are considered. The bibliography includes 122 references.

  15. Measurement of glomerular filtration in dogs by 51Cr-EDTA and 113In-DTPA

    International Nuclear Information System (INIS)

    Maliska, C.; Saraiva, J.C.G.

    1977-01-01

    The glomerular filtration rate (GFR) was measured in 15 normal dogs using 51 Cr-EDTA and 113 sup(m) In-DTPA, by a single injection technique. The results of GFR measurements was 3,01 (S.D. + - 0,71) ml/min/kg body weight, and 70,44 (S.D. + - 19,60) ml/min/m 2 surface area. Difference in GFR (means) between the measurement by 51 Cr-EDTA and 113 sup(m) In-DTPA and between the male and female group was not statistically significant (p [pt

  16. Modelling the effect of continuous infusion DTPA therapy on the retention and dosimetry of inhaled actinides

    International Nuclear Information System (INIS)

    Guilmette, R.A.; Muggenburg, B.A.

    1989-01-01

    A biokinetic model of the treatment of dogs that inhaled 241 AmO 2 aerosols with continuously infused DTPA has been adapted from a previously published model by Mewhinney and Griffith. This model was parameterised to simulate both the tissue retention and the excretion of 241 Am, and was used to estimate the cumulative radiation doses to tissues at risk from the α radiation of 241 Am. The results showed that at 64 days after exposure, the liver dose of the DTPA-treated animals was 3% that of the corresponding controls, the skeleton dose was 2%, the kidney dose was 4% and the lung dose was 67% of controls. (author)

  17. Significance of renal scintigraphy with 99mTc-DTPA for the diagnosis of diabetic nephropathy

    International Nuclear Information System (INIS)

    Lin Jun; Zhao Shuhao; Guo Rong; Lin Haoxue; Xie Zhichun

    1995-01-01

    99m Tc-DTPA renography was performed in 64 cases of type II diabetes mellitus and 20 control subjects. The value of GFR in the controls was 113 +-11.7 ml/min. The value of GFR in 15 of 43 patients with negative proteinuria was more than 140 ml/min, but GFR in the 21 diabetes with positive proteinuria was 76 +- 32.9 ml/min. These data indicated that 99m Tc-DTPA renography is an accurate and sensitive method for evaluation of hyperfiltration in early diabetes mellitus

  18. The radiochemical purity of technetium-99m-tin-diethylene-triamino-pentaacetic acid (DTPA) complex

    International Nuclear Information System (INIS)

    Besnard, M.; Costerousse, O.; Merlin, L.; Coehn, Y.

    1975-01-01

    The effect on radiochemical purity was studied as a function of the storage period of tin-DTPA solution and of the technetium-complex solution. The quantity of the pertechnetate ions present in the solution is determined by ascending paper chromatography, and an attempt was made to clarify the bond type of technetium by a spectrophotometric method. The tin-DTPA solutions for complexing of the reduced technetium are stable over a period of 8 weeks. The yield of the radiopharmaceutical product is better than 95%. (G.Gy.)

  19. Sequential Gd-DTPA-enhanced MR imaging after surgical treatment of osteonecrosis of the femoral head

    International Nuclear Information System (INIS)

    Postema, S.; Bloem, J.L.; Bloem, R.M.

    1990-01-01

    This paper evaluates the perfusion of necrotic bone and surrounding areas in osteonecrosis of the femoral head following surgical treatment with MR imaging before and after Gd-DTPA enhancement. Thirteen surgically treated hips (one Ficat stage 1, three stage 2, one stage 2-3, five stage 3, three stage 4) and four hips that were treated conservatively were studied with MR imaging before and after intravenous administration of GD-DTPA. Follow-up studies range from 7 days to 33 months

  20. Neurofibromas: location by scanning with Tc-99m DTPA. Work in progress

    International Nuclear Information System (INIS)

    Mandell, G.A.; Herrick, W.C.; Harcke, H.T.; Sharkey, C.; Brooks, K.M.; MacEwen, G.D.

    1985-01-01

    The accumulation of technetium-99m diethylenetriamine pentaacetic acid (Tc-99m DTPA) in benign soft-tissue neurofibromatosis tumors is reported. In a series of 16 patients with clinical stigmata of neurofibromatosis, 28 sites of abnormal soft-tissue localization of the isotope observed scintigraphically were documented to be sites of soft-tissue tumor by clinical and/or radiographic (predominantly computed tomographic) correlations. The smallest lesion detected was a 1.5-cm subcutaneous neurofibroma. Normal physiologic nonrenal distribution of the Tc-99m DTPA was established by scintigraphic imaging of a control population

  1. Postdiscectomy lumbar MR with GD-DTPA in differentation between scar tissue and recurrent prolapse

    International Nuclear Information System (INIS)

    Majewski, A.; Pedrosa, P.; Schuth, M.; Higer, H.P.

    1989-01-01

    The non-invasive diagnostic possibilities of MR have resulted in better diagnosis of degenerative spinal diseases. Twenty-one patients with failed back surgery syndrome (postdiscectomy syndrome) were studied to evaluate the possibility of 1-Tesla magnetic resonance (MR) imaging with gadolinium diethylene triamine pentaacetic acid (Gd-DTPA) in differentiating post operative scar tissue from recurrent disc herniation. The enhanced MR studies correctly depicted the character of abnormal epidural tissue in all patients. We conclude that MR with Gd-DTPA might be the method of choice to differentiate reliably postoperative epidural fibrosis from recurrent disc prolapse. (orig.) [de

  2. Does Gd-DTPA help in separating tumor from syrinx or cyst in the spinal cord

    International Nuclear Information System (INIS)

    Slasky, B.S.; Niendorf, H.P.; Steiner, R.E.; Bydder, G.M.; Young, I.R.

    1987-01-01

    There is some difficulty in differentiating among syringomyelia, syringomyelia in association with tumor, and cystic tumor in the spinal cord with MR imaging. The role of the paramagnetic contrast agent Gd-DTPA in evaluating this problem was studied in 16 patients. Contrast enhancement was observed in all 12 patients with histologically proved tumors. Enhancement was marked in eight cases, moderate in two cases, and mild in two cases. Compared to the unenhanced images, the images obtained after Gd-DTPA administration delineated more clearly and accurately the exact location and extent of tumor in cord cavitation. This information was extremely helpful in biopsy, definitive surgery, and radiation therapy

  3. Salicylic acid failed to increase the efficacy of Ca-DTPA in the decorporation of plutonium and americium

    International Nuclear Information System (INIS)

    Jones, C.W.; Lloyd, R.D.; Mays, C.W.

    1979-01-01

    Male and female C57BL/Do mice were each given a single i.p. injection of 237+239 Pu + 241 Am as the citrate complex at 45 days of age. Twice weekly i.p. injecctions of either 500 μmol/kg Ca-DTPA or 500 μmol/kg Ca-DTPA, mixed just before injection with 2000 μmol/kg salicylic acid (SA), were begun 3 days after nuclide administration and continued for 5 weeks. Control mice were injected each time with isotonic saline. Nuclide retention was determined by in vivo counting using NaI(T1) spectrometry. At the end of treatment, total-body retention of Pu or Am in the mice given Ca-DTPA was significantly lower (P < 0.001) than in the control animals. Mice treated with Ca-DTPA + SA were statistically indistinguishable from mice treated with Ca-DTPA

  4. Gd-Complexes of New Arylpiperazinyl Conjugates of DTPA-Bis(amides: Synthesis, Characterization and Magnetic Relaxation Properties

    Directory of Open Access Journals (Sweden)

    Abdullah O. Ba-Salem

    2015-04-01

    Full Text Available Two new DTPA-bis(amide based ligands conjugated with the arylpiperazinyl moiety were synthesized and subsequently transformed into their corresponding Gd(III complexes 1 and 2 of the type [Gd(LH2O]·nH2O. The relaxivity (R1 of these complexes was measured, which turned out to be comparable with that of Omniscan®, a commercially available MRI contrast agent. The cytotoxicity studies of these complexes indicated that they are non-toxic, which reveals their potential and physiological suitability as MRI contrast agents. All the synthesized ligands and complexes were characterized with the aid of analytical and spectroscopic methods, including elemental analysis, 1H-NMR, FT-IR, XPS and fast atom bombardment (FAB mass spectrometry.

  5. Functional dynamic MR imaging and pharmacokinetics of Gd-DTPA in patients with renal failure

    International Nuclear Information System (INIS)

    Krestin, G.P.; Neufang, K.F.R.; Friedmann, G.; Clauss, W.; Schuhmann-Giampieri, G.; Stoeckl, B.

    1989-01-01

    This paper reports excretion of Gd-DTPA analyzed in 20 patients with renal parenchymal disease and decreased creatinine clearance (20-80 mL/min) and compared with excretion in five patients with normal renal function. All 25 underwent a dynamic MR study that employed fast gradient-echo sequences with single images during breath holding. The time between appearance of the contrast agent in the renal cortex and signal intensity drop in the medulla was an indicator of glomerular filtration rate and correlated well with creatinine clearance values. Fractionate urine collection and serum analysis up to 120 hours showed a prolonged but complete (98%) elimination of Gd-DTPA. Renal functional parameters did not change after administration of Gd-DTPA, and no nephrotoxic effects were observed. Thus, MR imaging provides a good quantitative evaluation of the glomerular filtration rate; moreover, administration of Gd-DTPA in patients with renal failure does not impair excretory function and can therefore be safely applied in patients with reduced excretory function

  6. Technology of DTPA and immunoglobulins conjugation and their attachment to 90Y and 177Lu radionuclides

    International Nuclear Information System (INIS)

    Rekova, M.; Jedinakova-Krizova, V.

    2010-01-01

    The aim of the study of labeling of ligand-antibody conjugates was to find optimal conditions of preparing of these conjugates and appropriate radioactivity of selected nuclide for applications in nuclear medicine. Conjugation of the γ-immunoglobulin G (human or bovine IgG, polyclonal antibodies) and bifunctional chelating agent, diethylenetriaminepentaacetic acid dianhydride (cDTPAA), was carried out. Various values of the cDTPAA/antibody ratio, the weight concentration of polyclonal or monoclonal antibodies (MEM-97) and buffers were used. Further, the labeling conditions of the DTPA-IgG conjugate by radionuclides 90 Y and 177 Lu were optimized, and the labeling yield and the conjugation ratio of prepared radionuclide-DTPA-IgG conjugates was determined. Optimal incubation time of the immunoglobulin conjugation was obtained at 30 min from mixing of individual components. The labeling yield of radionuclide-DTPA-antibody conjugate higher than 95% was achieved. Higher values of conjugation ratio of radionuclide-DTPA-antibody conjugate were achieved in 0.1 mol L -1 carbonate buffer, pH 8.5, and the 0.1 mol L -1 carbonate buffer is suitable for studied conjugation systems. This study showed that the labeling yield as well as the conjugation ratio of tested systems depend on the amount of antibody substance, bifunctional chelating agent/antibody molar ratio and pH value of the buffer used. (author)

  7. Modeling the effect of continuous infusion DTPA therapy on the retention and dosimetry of inhaled actinides

    International Nuclear Information System (INIS)

    Guilmette, R.A.; Muggenburg, B.A.

    1988-01-01

    A biokinetic model of the treatment of dogs that inhaled 241 AmO 2 aerosols with continuously infused DTPA has been adapted from a model previously published by Mewhinney and Griffith. This model simulated both the tissue retention and excretion of 241 Am, and was used to estimate the cumulative radiation doses to tissues at risk from 241 Am alpha radiation. The results showed that at 64 days after exposure, the liver dose of the DTPA-treated animals was 3% that of the corresponding controls, the skeletal dose was 2%, the kidney dose was 4%, and the lung dose was 67% of controls. This paper describes a biokinetic and dosimetric model that was adapted from a previously published model. It was developed to provide a means of estimating radiation doses for cases where continuously infused DTPA therapy is used to reduce radiation dose. The model was formulated for the case of 241 Am0 2 inhalation, a physicochemical form of Am that is moderately soluble in vivo, and one to which people have been exposed. Because adequate human data, particularly tissue data, are not available from cases of accidental human exposure to 241 Am, two published data sets from experiments in which Beagle dogs inhaled 241 Am0 2 aerosols have been used to obtain parameter estimates for the model. The model simulations were then used to provide dose estimates with and without infused-DTPA therapy. (author)

  8. An experimental model for measuring gastrointestinal bleeding rate using Tc-99m DTPA in rabbits

    International Nuclear Information System (INIS)

    Owunwanne, A.; Abdel-Dayem, H.M.; Sadek, S.; Yakoub, T.; Mahajan, K.K.; Ericsson, S.B.

    1987-01-01

    An animal experimental model to measure the rate of gastrointestinal bleeding rate in a rabbit using Tc-99m DTPA is described. It was possible to detect a bleeding rate of 0.1 ml/min. However, the model could not be used to calculate the minimum amount of radioactivity needed to detect the bleeding site. (orig.) [de

  9. Application of 99mTc-DTPA Radiotracer in Persian Cat's Renal ...

    African Journals Online (AJOL)

    cat's renal scintigraphy, and this makes it potentially useful in research and clinical practice. Keywords: ... DTPA kit. (Kavoshyar, Iran) was obtained from Iran Nuclear. Research Center. 99mTechnetium milked from molybdenum-technetium generator was prepared .... Preparation and Quality Control in Nuclear Medicine.

  10. Gd-DTPA-enhanced lesions in the brain of patients with acute optic neuritis

    DEFF Research Database (Denmark)

    Christiansen, P; Frederiksen, J L; Henriksen, O

    1992-01-01

    The cerebral hemispheres of 19 patients with acute monosymptomatic optic neuritis (AMON) were investigated using magnetic resonance imaging (MRI) and Gadolinium-DTPA (Gd-DTPA). Using T1-weighted and T2-weighted imaging sequences it was disclosed that 14 of 19 patients had lesions and that enhance......The cerebral hemispheres of 19 patients with acute monosymptomatic optic neuritis (AMON) were investigated using magnetic resonance imaging (MRI) and Gadolinium-DTPA (Gd-DTPA). Using T1-weighted and T2-weighted imaging sequences it was disclosed that 14 of 19 patients had lesions...... and that enhancement was seen in seven patients. It is known that patients with AMON and silent lesions in the CNS have a highly increased risk of developing multiple sclerosis (MS) later on. If it is accepted that a silent lesion in patients with AMON does represent a multiple sclerosis (MS) plaque......, and that an enhancing silent lesion represents an acute MS lesion, we may hypothesize that the disease process ultimately leading to MS starts long before the first symptom or sign ever appears. It would seem that at least half of the silent lesions in the cerebral hemispheres of patients with AMON had existed before...

  11. Time-intensity curve in the abdominal aorta on dynamic contrast-enhanced MRI with high temporal and spatial resolution. Gd-EOB-DTPA versus Gd-DTPA in vivo

    International Nuclear Information System (INIS)

    Fujinaga, Yasunari; Tsukahara, Yoshinori; Sugiyama, Yukiko; Kadoya, Masumi; Ueda, Hitoshi; Kitou, Yoshihiro

    2013-01-01

    The purpose of this study was to evaluate the difference in the time-intensity curves (TICs) of the abdominal aorta on dynamic contrast-enhanced MRI (DCE-MRI) between gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and gadolinium ethoxybenzydiethylenetriamine pentaacetic acid (Gd-EOB-DTPA). Ten healthy volunteers underwent DCE-MRI three times with the following protocol: group A, Gd-DTPA at an injection rate of 3 ml/s; group B, Gd-EOB-DTPA, 3 ml/s; group C, Gd-EOB-DTPA, 1.5 ml/s. Signal intensities (SIs) of the abdominal aorta were measured, and the contrast enhancement ratio (CER) was calculated. Time-to-CER curves were compared among the three groups. The differences in maximum CER (CER max ) and time-to-peak of CER were analyzed. The time-to-CER curve showed a double peak pattern in group A and single-peak pattern in groups B and C. The mean time between the first and the second peak was 6.2 s. The mean CER max of each group was 4.50, 4.52 and 4.27, respectively. In group A, B and C, the mean time-to-peak was 14.6, 10.6 and 12.6 s, respectively. There was a significant difference between group A and B (P<0.01). To set up the optimal protocol for abdominal DCE-MRI, it should be noted that TIC in the Gd-DTPA and Gd-EOB-DTPA group showed different patterns, and a slower injection rate showed a less abrupt SI change in the Gd-EOB-DTPA group than in the Gd-DTPA group. (author)

  12. Comparison of contract appearance of gadobenate-dimeglumine and GA-DTPA in intra-axial brain tumors; Vergleich des Kontrastverhaltens von Gadobenat-Dimeglumine und Gd-DTPA bei intraaxialen Hirntumoren. Eine doppelblinde randomisierte intraindividuelle Cross-over-Studie

    Energy Technology Data Exchange (ETDEWEB)

    Essig, M.; Knopp, M.V. [Deutsches Krebsforschungszentrum Heidelberg (Germany). Abt. Radiologische Diagnostik und Therapie; Hartmann, M.; Jansen, O. [Abt. Klinische Neuroradiologie, Univ. Heidelberg (Germany); Lodemann, K.P.; Seeberg, A. [Bracco-Byk-Gulden, Konstanz (Germany); Runge, V.M. [Univ. of Kentucky, Lexington (United States)

    2001-12-01

    The purposes of the study was to assess intraaxial brain tumors by a blinded comparison of gadobenat-dimeglumine and Gd-DTPA 27 patients with known cerebral gliomas or metastases were included into an intra-individual randomized double-blinded cross-over study. The protocol included T1 SE, T2 FSE and after contrast a series of five T1 SE sequences followed by T1 SE with MT, T1 SE, and 3D GRE sequences. Imaging data acquired at two centers were assessed on-site by the investigators and off-site by two experienced readers using quantitative and qualitative criteria. For a quantitative analysis tumor contrast and contrast-to-noise ratios were determined out of ROI in tumor, unaffected white matter, a region outside the head, and an external reference tube. For the qualitative assessment on- and off-site readers were asked to compare both MR scans for lesion contrast, lesion delineation and information upon the internal morphology and structure. In the quantitative analysis lesions examined with gadobenat-dimeglumine present a maximal 26% increase of the lesion contrast. In both, the on-site, as well as the off-site assessment the intensity of enhancement and the lesion contrast were found to be significantly better with gadobenat-dimeglumine enhanced MRI. There was a trend towards gadobenat-dimeglumine for the delineation of the lesion from the surrounding tissue and the internal lesion morphology. Based on our observations gadobenat-dimeglumine proved to be a safe and valuable contrast media for the assessment of CNS neoplasms. Compared with Gd-DTPA it provides a more intense contrast enhancement and a better tumor contrast which might be of importance for the further management of these patients. (orig.) [German] In einer doppelt verblindeten randomisierten intraindividuel en Cross-Over Vergleichsuntersuchung wurden 27 Patienten mit intraaxialen Hirntumoren mittels der MR-Kontrastmittel Gadobenat-Dimeglumine (Multihance trademark) und Gd-DTPA (Magnevist{sup circled

  13. Early phase detection of bile leak after hepatobiliary surgery: value of Gd-EOB-DTPA-enhanced MR cholangiography.

    Science.gov (United States)

    Alegre Castellanos, Alvaro; Molina Granados, Juan Felix; Escribano Fernandez, Jose; Gallardo Muñoz, Inmaculada; Triviño Tarradas, Francisco de Asis

    2012-10-01

    To assess the value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MR cholangiography for the detection of bile leaks after hepatobiliary surgery. Twenty-three patients with symptoms suggestive of bile leak underwent conventional fat-suppressed T1- and T2-weighted MR cholangiography followed by Gd-EOB-DTPA-enhanced MR cholangiography using gradient-echo (GRE) T2-weighted sequences and fat-suppressed T1-weighted 3D gradient-echo sequences 20 min after an intravenous bolus of Gd-EOB-DTPA. The results of Gd-EOB-DTPA-enhanced MR cholangiography correlated with clinical findings, surgical repair, and the results of endoscopic retrograde cholangiopancreatography and percutaneous transhepatic cholangiography. The results of Gd-EOB-DTPA-enhanced MR cholangiography were negative in 13 patients (cholecystectomy 5, liver transplantation 2, liver resection for focal lesions 2, cholangiocarcinoma 1, and partial hepatectomy after liver injury 1). In 10 patients in whom bile leaks were detected, this complication occurred after liver resection for focal lesions in 3, cholecystectomy in 4, liver transplantation in 2, and liver resection for intrahepatic cholangiocarcinoma in 1. The diagnostic accuracy of Gd-EOB-DTPA-enhanced MR for the detection or exclusion of bile leaks was 100%. Gd-EOB-DTPA-enhanced MR cholangiography is a highly reliable technique for the detection of bile leaks after hepatobiliary surgery and may avoid the use of other, potentially risky invasive diagnostic techniques.

  14. Multifunctional switches based on bis-imidazole derivative

    Indian Academy of Sciences (India)

    Administrator

    the coloured species make the derivative a candidate for applications in optical data storage. Acknowledgements. The authors wish to thank King Abdul Aziz City for. Science and Technology (KACST) for funding this research work via grant no. At–27-68. References. 1. Gust D, Moore T A and Moore A L 2001 Acc. Chem.

  15. Coordination of Tridentate Schiff Base Derivatives of 4 ...

    African Journals Online (AJOL)

    NICO

    KEYWORDS. Tridentate, rhenium(V), imido, crystal structures. 1. Introduction. The research interest in pyrazolone (pz) and its derivatives is mainly due to their pharmaceutical properties. Pz is a five-membered lactam ring, containing two nitrogen atoms and a ketone, and it is an active moiety in pharmacology, such as for.

  16. Histopathological study correlated with Gd-DTPA-enhanced MR imaging in glioma

    International Nuclear Information System (INIS)

    Komatsu, Yoji; Yoshii, Yoshihiko; Nose, Tadao; Yamada, Takashi; Takano, Shingo; Kobayashi, Eiki.

    1989-01-01

    In order to clarify the histopathological correlation with Gd-DTPA-enhanced MR imaging in glioma, brain specimens from seven cases of glioblastoma multiforme, two cases of benign astrocytoma, and two cases of radiation injury were investigated. T 1 -weighted MR imagings were obtained before and after the injection of Gd-DTPA (dose: 0.1 m mol/kg). The authors classified the patterns of enhancement into four types : (1) Delineated enhanced type (a delineated and homogeneously enhanced solid or a ring-like region): This type correlated with two histopathological types. One was stable or had a slowly proliferating tumoral tissue. Their specimens show a moderately increased vascularity and not so anaplastic tumor cells. The other was radiation-injury tissue. Here coagulation necrosis and fibrinoid necrosis were found, but no tumor cells. (2) Undelineated enhanced type (an undelineated and heterogeneously enhanced solid region): This type correlated with viable and highly proliferating glioma tissue. A high vascularity of the endotherial proliferating vessels, highly anaplastic tumor cells, and mitosis were observed. (3) Slightly enhanced type: In this area, edema with increasing capillary vessels was observed. Some tumor cells were also seen. (4) Non-enhanced type: Normal brain tissue; benign astrocytoma were not enhanced by Gd-DTPA. X-ray CT scanning is said to be unable to distinguish viable tumoral tissue from radiation-injury tissue. Histopathological correlations with Gd-DTPA-enhanced MR imagings have shown that the undelineated and heterogeneously enhanced areas corresponded to proliferating viable glioma tissue, while the delineated and homogeneously enhanced areas corresponded to radiation-injury tissue or to relatively stable glioma tissue. Gd-DTPA enhancement corresponded well to the increased vascularity of abnormal vessels, but not necessarily to tumoral cells. (author)

  17. Comparison of contract appearance of gadobenate-dimeglumine and GA-DTPA in intra-axial brain tumors

    International Nuclear Information System (INIS)

    Essig, M.; Knopp, M.V.; Lodemann, K.P.; Seeberg, A.; Runge, V.M.

    2001-01-01

    The purposes of the study was to assess intraaxial brain tumors by a blinded comparison of gadobenat-dimeglumine and Gd-DTPA 27 patients with known cerebral gliomas or metastases were included into an intra-individual randomized double-blinded cross-over study. The protocol included T1 SE, T2 FSE and after contrast a series of five T1 SE sequences followed by T1 SE with MT, T1 SE, and 3D GRE sequences. Imaging data acquired at two centers were assessed on-site by the investigators and off-site by two experienced readers using quantitative and qualitative criteria. For a quantitative analysis tumor contrast and contrast-to-noise ratios were determined out of ROI in tumor, unaffected white matter, a region outside the head, and an external reference tube. For the qualitative assessment on- and off-site readers were asked to compare both MR scans for lesion contrast, lesion delineation and information upon the internal morphology and structure. In the quantitative analysis lesions examined with gadobenat-dimeglumine present a maximal 26% increase of the lesion contrast. In both, the on-site, as well as the off-site assessment the intensity of enhancement and the lesion contrast were found to be significantly better with gadobenat-dimeglumine enhanced MRI. There was a trend towards gadobenat-dimeglumine for the delineation of the lesion from the surrounding tissue and the internal lesion morphology. Based on our observations gadobenat-dimeglumine proved to be a safe and valuable contrast media for the assessment of CNS neoplasms. Compared with Gd-DTPA it provides a more intense contrast enhancement and a better tumor contrast which might be of importance for the further management of these patients. (orig.) [de

  18. [Semisynthetic cellulose derivatives as the base of hydrophilic gel systems].

    Science.gov (United States)

    Bajerová, M; Gajdziok, J; Dvorácková, K; Masteiková, R; Kollár, P

    2008-04-01

    The field of drug technology widely ulilizes gel systems of high-molecular substances, which have a number of advantages, such as low toxicity, availability, unique physical properties, biocompatibility, mucoadhesivity, and others. Gel systems are used in the field of local as well as general therapy, in both shape-specific and shape-non-specific dosage forms, in medicaments of the first, second, and third generations. An important group of gels employed in pharmacy are hydrophilic gels or hydrogels, most frequently composed of hydrophilic polymers of natural, semisynthetic and synthetic origin. Though cellulose derivatives as the representatives of polymers of semisynthetic origin are used in pharmaceutical technology for a long time, their research continues and their other possible uses are being searched for. Their advantages include especially safety, easy availability, and a relatively low price. The review paper describes selected cellulose derivatives, their properties and uses in pharmaceutical technology with regard to their use in the field of production of gel systems.

  19. Study for synovial lesions by MRI using gadolinium-DTPA (Gd-DTPA) in patients with early phase of rheumatoid arthritis

    International Nuclear Information System (INIS)

    Takano, Keiyu

    1993-01-01

    To evaluate the usefulness of magnetic resonanse imaging (MRI) enhanced with gadolinium-DTPA (Gd-DTPA) for the detection of the inflamed synovium and for the evaluation of the responce to therapy in rheumatoid arthritis, we studied 49 patients with rheumatoid arthritis (RA) according to the 1987 revised criteria of American Rheumatism Association (ARA), 6 patients with systemic lupus erythematosus (SLE) complicated by arthritis, 3 patients with osteoarthritis (OA), 2 patients with Sjoegren syndrome, 2 patients with progressive systemic sclerosis and 10 healthy volunteers as an age matched control. The 49 patients with RA were divided into three groups: 1) early phase of RA, 2) non progressing RA and 3) slowly progressing RA, and the stage classification of plain X-ray film and enhancement pattern of MR imaging were classified into three groups. Synovial enhancement showed a linear, band-like or diffuse pattern. Almost all cases in early phase of RA group and non progressing RA group showed a linear pattern, a band-like pattern or even no enhancement, while slowly progressing group of stage II or higher showed the diffuse pattern of enhancement in all except 2 cases. Moreover, the linear pattern, the band-like pattern or even no contrast enhancement were seen in all except 1 stage I patient, whereas 26 out of 29 patients with stage II or higher change showed diffuse contrast enhancement. Furthermore, a comparison of MR images before and after administration of disease modifying antirheumatic drugs (DMARDs) in 10 patients showed that the improvement of clinical symptomes correlated fairly well with reduction of contrast enhancement. The present study suggested that MRI of the wrist using Gd-DTPA enhancement may be useful for the diagnosis of RA, the prediction of articular damage, and judgement of the response to therapy. (author)

  20. Study for synovial lesions by MRI using gadolinium-DTPA (Gd-DTPA) in patients with early phase of rheumatoid arthritis

    Energy Technology Data Exchange (ETDEWEB)

    Takano, Keiyu (Saint Marianna Univ., Kawasaki, Kanagawa (Japan). School of Medicine)

    1993-02-01

    To evaluate the usefulness of magnetic resonanse imaging (MRI) enhanced with gadolinium-DTPA (Gd-DTPA) for the detection of the inflamed synovium and for the evaluation of the responce to therapy in rheumatoid arthritis, we studied 49 patients with rheumatoid arthritis (RA) according to the 1987 revised criteria of American Rheumatism Association (ARA), 6 patients with systemic lupus erythematosus (SLE) complicated by arthritis, 3 patients with osteoarthritis (OA), 2 patients with Sjoegren syndrome, 2 patients with progressive systemic sclerosis and 10 healthy volunteers as an age matched control. The 49 patients with RA were divided into three groups: (1) early phase of RA, (2) non progressing RA and (3) slowly progressing RA, and the stage classification of plain X-ray film and enhancement pattern of MR imaging were classified into three groups. Synovial enhancement showed a linear, band-like or diffuse pattern. Almost all cases in early phase of RA group and non progressing RA group showed a linear pattern, a band-like pattern or even no enhancement, while slowly progressing group of stage II or higher showed the diffuse pattern of enhancement in all except 2 cases. Moreover, the linear pattern, the band-like pattern or even no contrast enhancement were seen in all except 1 stage I patient, whereas 26 out of 29 patients with stage II or higher change showed diffuse contrast enhancement. Furthermore, a comparison of MR images before and after administration of disease modifying antirheumatic drugs (DMARDs) in 10 patients showed that the improvement of clinical symptomes correlated fairly well with reduction of contrast enhancement. The present study suggested that MRI of the wrist using Gd-DTPA enhancement may be useful for the diagnosis of RA, the prediction of articular damage, and judgement of the response to therapy. (author).

  1. Radiation protect during the ventilation scintigraphy of Tc99m DTPA radioaerosol in pediatric application

    International Nuclear Information System (INIS)

    Chen, Yu-Wen; Dai, Zen-Kong; Huang, Ying-Fong; Jong, Shiang-Bing

    2000-01-01

    Lung ventilation-perfusion scintigraphy is of great value for the management of patients with both primary lung disease and heart disease, by proving patho- physiological information of importance for the diagnosis, follow-up and functional evaluation of the patients. Krypton 81m radioactive gas is preferable for pediatric application due to its short half-life. However, the rubidium-krypton 81m generator is not popular in hospital of our country. Tc99m DTPA radioaerosol ventilation scintigraphy has its unique convenient for clinical application. But, the most disadvantage of clinical application of Tc99m DTPA radioaerosol is contamination of environment when the poor-cooperative patient can't breathe by mouth. For this reason, we design the certain procedure to reduce the radioaerosol contamination. During May to Aug., 1999, we collect 36 pediatric patients (male to female ratio 2:1, age from 6 months to 20 years old) with clinical history of lung or heart disease, including congenital heart disease, asthma and so on. Before the cases receive 10 to 15 mCi Tc99m DTPA radioaerosol ventilation scan, all of them were trained with breath training. And during the ventilation scintigraphy, the special mouth mask is designed to prevent the radioaerosol leakage into atmosphere. Then Geiger-Muller survey meter was arranged to detect the environmental contamination of radioaerosol in the mask, one and two metes away from the mask every 10 minutes during ventilation scintigraphy procedure and 1 hour after finishing image. Two nuclear medicine physicians evaluated imaging quality of ventilation scintigraphy. Results: Among thirty-six pediatric patients with prior breath training, thirty-two cases are successful to proceed the Tc99m DTPA ventilation scintigraphy. The other four cases that were under three-year-old fail to receive ventilation scintigraphy. There is limited detectable radioactivity in the mouth mask at early 10 minute by Geiger-Muller counter. No significant

  2. Impact of gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance on the non-invasive diagnosis of small hepatocellular carcinoma: a prospective study.

    Science.gov (United States)

    Granito, A; Galassi, M; Piscaglia, F; Romanini, L; Lucidi, V; Renzulli, M; Borghi, A; Grazioli, L; Golfieri, R; Bolondi, L

    2013-02-01

    Gadoxetic acid (Gd-EOB-DTPA) is a 'hepatocyte-specific' contrast agent for magnetic resonance (MR) in both the vascular and the hepatobiliary phases. To evaluate the contribution of the hepatobiliary phase of Gd-EOB-DTPA MR in the diagnosis of small hepatocellular carcinoma (HCC) in cirrhotic patients under surveillance. Between 2008 and 2011, 48 consecutive small (10-30 mm) liver nodules were detected in 33 patients, who prospectively underwent contrast-enhanced ultrasound (CEUS), Gd-EOB-DTPA-enhanced MR and helical-computed tomography (CT) in a blind study. The diagnosis of HCC was established according to AASLD 2005 criteria. Of the 48 nodules, 38 (79%) were diagnosed as HCC, 24 (63%) of them based on AASLD non-invasive criteria, 11 diagnosed at histology and 3 during follow-up. The typical vascular pattern (arterial hypervascularisation and venous/late washout) was detected in 30 (79%) HCC nodules by MR, in 22 (58%) by CT and in 17 (45%) by CEUS. Hypointensity during the MR hepatobiliary phase was observed in all HCC nodules and in 3 nonmalignant nodules (sensitivity 100%, specificity 70%, positive predictive value 93%, negative predictive value 100%, positive likelihood ratio 3.33, negative likelihood ratio 0). Eight (21%) of the 38 HCC nodules, 7 of which lacked the typical vascular features at any of the imaging modalities, showed washout in the portal/venous phase and hypointensity in the hepatobiliary phase at MRI, while this pattern was not detected in any nonmalignant lesion. Gadoxetic acid magnetic resonance may enhance the sensitivity of the non-invasive diagnosis of small hepatocellular carcinoma nodules in cirrhotic patients under surveillance. Double hypointensity in the portal/venous and hepatobiliary phases could be considered a new magnetic resonance pattern, highly suggestive of hypovascular hepatocellular carcinoma. © 2012 Blackwell Publishing Ltd.

  3. Platelet-Rich Blood Derivatives for Stem Cell-Based Tissue Engineering and Regeneration

    NARCIS (Netherlands)

    Masoudi, E.A.; Ribas, J.; Kaushik, G.; Leijten, Jeroen Christianus Hermanus; Khademhosseini, A.

    2016-01-01

    Platelet-rich blood derivatives have been widely used in different fields of medicine and stem cell-based tissue engineering. They represent natural cocktails of autologous growth factors, which could provide an alternative for recombinant protein-based approaches. Platelet-rich blood derivatives,

  4. Glomerular filtration rate estimated from the uptake phase of 99mTc-DTPA renography in chronic renal failure

    DEFF Research Database (Denmark)

    Petersen, L J; Petersen, J R; Talleruphuus, U

    1999-01-01

    The purpose of the study was to compare the estimation of glomerular filtration rate (GFR) from 99mTc-DTPA renography with that estimated from the renal clearance of 51Cr-EDTA, creatinine and urea....

  5. Glomerular filtration rate estimated from the uptake phase of 99mTc-DTPA renography in chronic renal failure

    DEFF Research Database (Denmark)

    Petersen, L J; Petersen, J R; Talleruphuus, U

    1999-01-01

    The purpose of the study was to compare the estimation of glomerular filtration rate (GFR) from 99mTc-DTPA renography with that estimated from the renal clearance of 51Cr-EDTA, creatinine and urea.......The purpose of the study was to compare the estimation of glomerular filtration rate (GFR) from 99mTc-DTPA renography with that estimated from the renal clearance of 51Cr-EDTA, creatinine and urea....

  6. A new aid to decision-making tool for the elaboration of treatment protocols by the DTPA after dose calculations

    International Nuclear Information System (INIS)

    Fritsch, P.; Poncy, J.L.; Berard, P.; Grappin, L.; Blanchin, N.; Breustedt, B.; Blanchardon, E.

    2010-01-01

    The authors summarize the presentation of a new tool aimed at the assessment of the reduction of doses associated with different therapeutic protocols after an internal contamination by some Pu (by inhalation or injury). This tool couples a dissolution model and a model describing the evolution of the diethylene triamine penta acetate (DTPA) and of Pu-DTPA compounds. Some recent experimental data are used for validation purposes

  7. Preclinical evaluation of (111)In-DTPA-INCA-X anti-Ku70/Ku80 monoclonal antibody in prostate cancer.

    Science.gov (United States)

    Evans-Axelsson, Susan; Vilhelmsson Timmermand, Oskar; Welinder, Charlotte; Borrebaeck, Carl Ak; Strand, Sven-Erik; Tran, Thuy A; Jansson, Bo; Bjartell, Anders

    2014-01-01

    The aim of this investigation was to assess the Ku70/Ku80 complex as a potential target for antibody imaging of prostate cancer. We evaluated the in vivo and ex vivo tumor targeting and biodistribution of the (111)In-labeled human internalizing antibody, INCA-X ((111)In-DTPA-INCA-X antibody), in NMRI-nude mice bearing human PC-3, PC-3M-Lu2 or DU145 xenografts. DTPA-conjugated, non-labeled antibody was pre-administered at different time-points followed by a single intravenous injection of (111)In-DTPA-INCA-X. At 48, 72 and 96 h post-injection, tissues were harvested, and the antibody distribution was determined by measuring radioactivity. Preclinical SPECT/CT imaging of mice with and without the predose was performed at 48 hours post-injection of labeled DTPA-INCA-X. Biodistribution of the labeled antibody showed enriched activity in tumor, spleen and liver. Animals pre-administered with DTPA-INCA-X showed increased tumor uptake and blood content of (111)In-DTPA-INCA-X with reduced splenic and liver uptake. The in vitro and in vivo data presented show that the (111)In-labeled INCA-X antibody is internalized into prostate cancer cells and by pre-administering non-labeled DTPA-INCA-X, we were able to significantly reduce the off target binding and increase the (111)In-DTPA-INCA-X mAb uptake in PC-3, PC-3M-Lu2 and DU145 xenografts. The results are encouraging and identifying the Ku70/Ku80 antigen as a target is worth further investigation for functional imaging of prostate cancer.

  8. Preclinical evaluation of 111In-DTPA-INCA-X anti-Ku70/Ku80 monoclonal antibody in prostate cancer

    Science.gov (United States)

    Evans-Axelsson, Susan; Vilhelmsson Timmermand, Oskar; Welinder, Charlotte; Borrebaeck, Carl AK; Strand, Sven-Erik; Tran, Thuy A; Jansson, Bo; Bjartell, Anders

    2014-01-01

    The aim of this investigation was to assess the Ku70/Ku80 complex as a potential target for antibody imaging of prostate cancer. We evaluated the in vivo and ex vivo tumor targeting and biodistribution of the 111In-labeled human internalizing antibody, INCA-X (111In-DTPA-INCA-X antibody), in NMRI-nude mice bearing human PC-3, PC-3M-Lu2 or DU145 xenografts. DTPA-conjugated, non-labeled antibody was pre-administered at different time-points followed by a single intravenous injection of 111In-DTPA-INCA-X. At 48, 72 and 96 h post-injection, tissues were harvested, and the antibody distribution was determined by measuring radioactivity. Preclinical SPECT/CT imaging of mice with and without the predose was performed at 48 hours post-injection of labeled DTPA-INCA-X. Biodistribution of the labeled antibody showed enriched activity in tumor, spleen and liver. Animals pre-administered with DTPA-INCA-X showed increased tumor uptake and blood content of 111In-DTPA-INCA-X with reduced splenic and liver uptake. The in vitro and in vivo data presented show that the 111In-labeled INCA-X antibody is internalized into prostate cancer cells and by pre-administering non-labeled DTPA-INCA-X, we were able to significantly reduce the off target binding and increase the 111In-DTPA-INCA-X mAb uptake in PC-3, PC-3M-Lu2 and DU145 xenografts. The results are encouraging and identifying the Ku70/Ku80 antigen as a target is worth further investigation for functional imaging of prostate cancer. PMID:24982817

  9. Evaluation of lung epithelial permeability in the volatile substance abuse using Tc-99m DTPA aerosol scintigraphy

    International Nuclear Information System (INIS)

    Cayir, D.; Demirel, K.; Korkmaz, M.; Koca, G.

    2011-01-01

    Chronic inhalant use is associated with significant toxic effects, including neurological, renal, hepatic, and pulmonary damage. However, there is a paucity of reports regarding respiratory complications in inhalant abusers. The aim of this study was to evaluate pulmonary epithelial permeability in the volatile substance abuse (VSA) using technetium-99m-labeled diethylenetriamine pentaacetic acid (Tc-99m DTPA) aerosol scintigraphy. This study included 18 patients with volatile substance abuse and 18 volunteer controls. All of patients and controls were smokers. Tc-99m DTPA aerosol scintigraphy was performed in all cases. Time-activity curves from each lung were generated and clearance half-time (T 1/2 ) of Tc-99m DTPA were calculated. T 1/2 of whole lung was calculated as a mean of the T 1/2 of left and right lung. The T 1/2 values of Tc-99m DTPA clearance in the substance abusers were significantly decreased as compared to the control group with respective mean values of 28.86±8.44, and 62.14±26.12 min (p=0.001). It was seen Tc-99m DTPA clearance from lung was faster as the duration of substance abuse was increased. Tc-99m DTPA pulmonary clearance is markedly accelerated in the volatile substance abuse. This suggests that inhalant abuse of substance may produce abnormalities in pulmonary alveolo-capillary membrane function. (author)

  10. A novel fluorescent probe (dtpa-bis(cytosine)) for detection of Eu(III) in rare earth metal ions

    Science.gov (United States)

    Yang, Fan; Ren, Peipei; Liu, Guanhong; Song, Youtao; Bu, Naishun; Wang, Jun

    2018-03-01

    In this paper, a novel fluorescent probe, dtpa-bis(cytosine), was designed and synthesized for detecting europium (Eu3 +) ion. Upon addition of Eu3 + ions into the dtpa-bis(cytosine) solution, the fluorescence intensity can strongly be enhanced. Conversely, adding other rare earth metal ions, such as Y3 +, Ce3 +, Pr3 +, Nd3 +, Sm3 +, Gd3 +, Tb3 +, Dy3 +, Ho3 +, Er3 +, Yb3 + and Lu3 +, into dtpa-bis(cytosine) solution, the fluorescence intensity is decreased slightly. Some parameters affecting the fluorescence intensity of dtpa-bis(cytosine) solution in the presence of Eu3 + ions were investigated, including solution pH value, Eu3 + ion concentration and interfering substances. The detection mechanism of Eu3 + ion using dtpa-bis(cytosine) as fluorescent probe was proposed. Under optimum conditions, the fluorescence emission intensities of EuIII-dtpa-bis(cytosine) at 375 nm in the concentration range of 0.50 × 10- 5 mol • L- 1-5.00 × 10- 5 mol • L- 1 of Eu3 + ion display a better linear relationship. The limit of detection (LOD) was determined as 8.65 × 10- 7 mol • L- 1 and the corresponding correlation coefficient (R2) of the linear equation is 0.9807. It is wished that the proposed method could be applied for sensitively and selectively detecting Eu3 + ion.

  11. Comparison of the effects of high levels of DTPA and EDDHA on microelement uptake in bush beans

    Energy Technology Data Exchange (ETDEWEB)

    Wallace, A.; Soufi, S.M.; Alexander, G.V.; Cha, J.W.

    1976-01-01

    Bush beans (Phaseolus vulgaris L. var Improved Tendergreen) were grown for 21 days in noncalcareous Yolo loam soil with 0, 500, and 1000 ppM of DTPA (diethylene triamine pentaacetic acid) and also of EDDHA (ethylenediamine di(o-hydroxyphenylacetic acid)) applied as the Na salts. The objective was to learn more of DTPA-increased uptake of some heavy metals. The high levels of both agents tended to depress yields and result in leaf symptoms of excesses of metals. Both agents resulted in large increases of Fe in shoots. DTPA resulted in much larger increases in Zn, Cu, Mn, Co, Ni, and Pb than did EDDHA. For Cu, Co, and Ni the proportional increases with DTPA were greater than that for Fe. Aluminum was increased more by EDDHA than by DTPA while Mo was increased almost equally by the two chelating agents. Chromium was increased slightly by each agent, but V was unaffected. Leaf/stem ratios were increased by DTPA for Co and Ni and to a lesser extent for Fe and Zn indicating some transport through the plants as the metal chelates. Copper, Al, and Mn did not behave in this manner.

  12. synthesis of schiff bases derived from 2-hydroxy-1-naphth

    African Journals Online (AJOL)

    119 ppm). KEY WORDS: Schiff base, ... antimicrobial agents owing to their low toxicity, low cost and excellent activity against bacterial diseases. ..... antimicrobial activity and crystal structure of silver and copper complexes of sulfamethazine.

  13. Clearance of 99mTc-DTPA and experimentally increased alveolar surfactant content

    International Nuclear Information System (INIS)

    Bos, J.A.H.; Wollmer, P.; Bakker, W.; Hannappel, E.; Lachmann, B.

    1992-01-01

    The authors measured clearance of 99m Tc-labeled diethylenetriamine pentaacetic acid ( 99m Tc-DTPA) in rabbits with experimentally increased alveolar surfactant content. In one group of animals, surfactant production was increased by treatment with ambroxol, and another group of animals was treated with tracheal instillation of natural surfactant. A group of untreated control animals and animals treated with instillation of saline were also studied. Clearance was measured during standard conditions of mechanical ventilation and during ventilation with large tidal volumes. In ambroxol- and surfactant-treated groups, clearance rate was reduced compared with untreated control animals. In contrast, clearance rate increased after saline instillation. The differences were observed at both modes of ventilation. The findings indicate that the pulmonary surfactant system is a rate-limiting factor for the clearance of 99m Tc-DTPA and that the volume dependence of clearance is not explained by stretching of the alveolar wall only. 28 refs., 2 figs., 1 tab

  14. Dynamic 99mTc-DTPA renal gammagraphy with glomerular filtration rate determination

    International Nuclear Information System (INIS)

    Vivodova, M.; Hupka, S.; Michalko, J.; Lehotska, V.; Pipa, V.; Hasik, E.; Tomek, D.

    1989-01-01

    Using the method of 99m Tc-DTPA (diethylenetriaminepentaacetic acid) sequential renal gammagraphy with subsequent glomerular filtration rate determination by means of a gamma camera and a computer, a total of 285 patients were examined with suspected renal and urinary tract diseases, subjects after surgery on these organs or those serving as controls after drug therapy. With the help of a modified application computer program, a study was designed to evaluate quantitatively some functional parameters and to determine the total and the separate glomerular filtration rate values by 99m Tc-DTPA according to Gates. The benefits of the method are that it is non-invasive, rapid, atraumatic, with low exposure to radiation while offering a broad range of applications in routine diagnostic practice of nephrology, and especially so in pediatric patients. (author). 7 figs., 3 tabs., 18 refs

  15. Gd-DTPA in the evaluation of the normal and adnormal cavernous sinus

    International Nuclear Information System (INIS)

    Marks, M.P.; Thrush, A.; Enzmann, D.

    1989-01-01

    This paper reports on Gd-DTPA used in the evaluation of normal and abnormal cavernous sinus anatomy. Twenty-five normal subjects and 11 patients with cavernous sinus invasion were studied before Gd-DTPA enhancement. Normal studies were assessed for the conspicuity of the dural margins, the trigeminal cistern, and intracavernous and exiting cranial nerves. Contrast medium enhancement improved deductibility of the medical cavernous sinus margin (68% vs 38% on precontrast images) and intracavernous cranial nerves. Cranial nerves were inconsistently seen even on postcontrast images (cranial nerve III, 88%; v 1 , 36%, V 2 , 38%). On the abnormal images, contrast enhancement was beneficial in defining the relationship of tumor to parasellar structures, egress of tumor through bony foramina, and compression of the trigeminal cistern

  16. Gadolinium-DTPA: value in MR imaging of extraspinal musculoskeletal infections

    International Nuclear Information System (INIS)

    Haddad, M.C.; Sharif, H.S.; Aabed, M.Y.; Al Shahed, M.S.; Sammak, B.M.; Clark, D.C.

    1993-01-01

    To determine if paramagnetic contrast agents can improve the detection, delineation, and characterization of extraspinal musculoskeletal infections (MSI) on magnetic resonance (MR) imaging, 42 patients with clinical suspicion of MSI underwent MR imaging before and after intravenous administration of gadolinium-DTPA. The lesions consisted of 27 proven infections and 15 noninfective conditions. Specificity and accuracy in identifying infective lesions averaged 80% and 84%, respectively, on precontrast studies and 80% and 89% on the enhanced examinations, with no statistically significant difference. Rim enhancement around abscess loculi was the only pathognomonic sign of infection seen in ten patients with chronic osteomyelitis and pyogenic or tuberculous infections. In 17 patients with acute osteomyelitis, brucellosis, or mycetoma, detection and delineation of the lesions were best on precontrast studies, while postcontrast examinations resulted in underestimation of the extent of abnormalities in all cases. We conclude that intravenous gadolinium-DTPA has limited usefulness in the MR evaluation of extraspinal MSI. (orig.)

  17. Gadolinium-DTPA: value in MR imaging of extraspinal musculoskeletal infections

    Energy Technology Data Exchange (ETDEWEB)

    Haddad, M.C. [Dept. of Radiology, Riyadh Armed Forces Hospital, Riyadh (Saudi Arabia); Sharif, H.S. [Dept. of Radiology, Riyadh Armed Forces Hospital, Riyadh (Saudi Arabia); Aabed, M.Y. [Dept. of Radiology, Riyadh Armed Forces Hospital, Riyadh (Saudi Arabia); Al Shahed, M.S. [Dept. of Radiology, Riyadh Armed Forces Hospital, Riyadh (Saudi Arabia); Sammak, B.M. [Dept. of Radiology, Riyadh Armed Forces Hospital, Riyadh (Saudi Arabia); Clark, D.C. [Dept. of Radiology, Riyadh Armed Forces Hospital, Riyadh (Saudi Arabia)

    1993-12-01

    To determine if paramagnetic contrast agents can improve the detection, delineation, and characterization of extraspinal musculoskeletal infections (MSI) on magnetic resonance (MR) imaging, 42 patients with clinical suspicion of MSI underwent MR imaging before and after intravenous administration of gadolinium-DTPA. The lesions consisted of 27 proven infections and 15 noninfective conditions. Specificity and accuracy in identifying infective lesions averaged 80% and 84%, respectively, on precontrast studies and 80% and 89% on the enhanced examinations, with no statistically significant difference. Rim enhancement around abscess loculi was the only pathognomonic sign of infection seen in ten patients with chronic osteomyelitis and pyogenic or tuberculous infections. In 17 patients with acute osteomyelitis, brucellosis, or mycetoma, detection and delineation of the lesions were best on precontrast studies, while postcontrast examinations resulted in underestimation of the extent of abnormalities in all cases. We conclude that intravenous gadolinium-DTPA has limited usefulness in the MR evaluation of extraspinal MSI. (orig.)

  18. Design of Ion-Exchange Resins Through EDTA and DTPA Modified Ligands

    Directory of Open Access Journals (Sweden)

    2014-07-01

    Catechol, resorcinol, and their admixtures with EDTA and DTPA moieties were converted into polymeric resins by alkaline polycondensation with formaldehyde. The resins were characterized by FTIR spectroscopy, elemental analysis, ion-exchange capacity, and distribution coefficient (D for heavy metal and radionuclide such as Cs and Sr. 137Cs and 90Sr constitutes a major source of heat in nuclear waste streams and in regards to recent nuclear event their remediation in complex solution – sea water - represent an important issue.

  19. Gd-DTPA enhancement of the facial nerve in Ramsay Hunt's syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Tsutomu; Yanagida, Masahiro; Yamauchi, Yasuo (Kansai Medical School, Moriguchi, Osaka (Japan)) (and others)

    1992-10-01

    A total of 21 MR images in 16 Ramsay Hunt's syndrome were evaluated. In all images, the involved side of peripheral facial nerve were enhanced in intensity after Gd-DTPA. However, 2 cases had recovered facial palsy when MR images were taken. Nine of 19 cases with the enhancement of internal auditory canal portion had vertigo or tinnitus. Thus, it was suggested that the enhancement of internal auditory canal portion and clinical feature are closely related. (author).

  20. Gd-DTPA enhancement of the facial nerve in Ramsay Hunt's syndrome

    International Nuclear Information System (INIS)

    Kato, Tsutomu; Yanagida, Masahiro; Yamauchi, Yasuo

    1992-01-01

    A total of 21 MR images in 16 Ramsay Hunt's syndrome were evaluated. In all images, the involved side of peripheral facial nerve were enhanced in intensity after Gd-DTPA. However, 2 cases had recovered facial palsy when MR images were taken. Nine of 19 cases with the enhancement of internal auditory canal portion had vertigo or tinnitus. Thus, it was suggested that the enhancement of internal auditory canal portion and clinical feature are closely related. (author)

  1. Gd-EOB-DTPA-enhanced MR imaging findings of hepatocellular adenoma: correlation with pathological findings.

    Science.gov (United States)

    Takara, Kenichi; Saito, Kazuhiro; Kusama, Hiroshi; Tsuchida, Akihiko; Aoki, Tatsuya; Nagao, Toshitaka; Imai, Yasuharu; Taira, Junichi; Moriyasu, Fuminori; Tokuuye, Koichi

    2011-01-01

    We report a case of a 28-year-old woman with hepatocellular adenoma and correlate findings of pathology and magnetic resonance (MR) imaging with gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) enhancement. In the hepatobiliary phase, the peripheral region of the tumor that corresponded with proliferating hepatocytes with steatosis showed slight hypointensity compared with the surrounding liver parenchyma, and the central region of the tumor that corresponded with cellular areas showed isointensity.

  2. Separation of Am, Cm from Pm by elution chromatography with DTPA-lactic acid mixed solution

    International Nuclear Information System (INIS)

    Wei Liansheng; Zhang Zuyi; Zhong Jiahua

    1988-01-01

    The effect of various factors on the separation of Am and Cm from Pm in the cation exchange-DPTA (diethylenetiaminepenlaacetic acid)-lactic acid system is studied, such as the concentration of DTPA, pH of the eluant, temperature and flow rate. Separation results show that the recovery of Am and Cm is 99.18% and the decontamination factor of Am, Cm from Pm is 431

  3. Overview description of the base scenario derived from FEP analysis

    International Nuclear Information System (INIS)

    Locke, J.; Bailey, L.

    1998-01-01

    This report forms part of a suite of documents describing the Nirex model development programme. The programme is designed to provide a clear audit trail from the identification of significant features, events and processes (FEPs) to the models and modelling processes employed within a detailed performance assessment. A scenario approach to performance assessment has been adopted. It is proposed that potential evolutions of a deep geological radioactive waste repository can be represented by a base scenario and a number of variant scenarios. It is intended that assessment of the base scenario would form the core of any future performance assessment. The base scenario is chosen to be broad-ranging and to represent the natural evolution of the repository system and its surrounding environment. The base scenario is defined to include all those FEPs which are certain to occur and those which are judged likely to occur for a significant period of the assessment - timescale. Variant scenarios are defined by FEPs which represent a significant perturbation to the natural system evolution, for example the occurrence of a large seismic event. The structuring of FEPs on a Master Directed Diagram (MDD), provides a systematic framework for identifying those FEPs which form part of the natural evolution of the system and those which may define alternative potential evolutions of the repository system. In order to construct a description of the base scenario, FEPs have been grouped into a series of conceptual models. Conceptual models are groups of FEPs, identified from the MDD, representing a specific component or process within the disposal system. It has been found appropriate to define conceptual models in terms of the three main components of the disposal system: the repository engineered system, the surrounding geosphere and the biosphere. For each of these components, conceptual models provide a description of the relevant subsystem in terms of its initial characteristics

  4. Study of the cerebro-spinal fluid circulation indium 111 labelled DTPA. Report of 300 cases

    International Nuclear Information System (INIS)

    Moreau, R.; Askienazy, S.; Mathieu, E.; Moretti, J.-L.

    1976-01-01

    A study of the C.S.F. circulation by intrathecal injection of radioactive tracers is a usual technique of neurological exploration. Indium-111 DTPA has numerous advantages for this type of study. It is a chelating agent, the renal clearance of which is rapid and which has no toxicity at the dose injected. Indium-111 is a cyclotron product with a half-life (2.8 days) compatible with the duration of the examination. Finally the dose of radioactivity delivered by this isotope is less than that of iodine 131, Technetium 99m, and ytterbium 169. In normal subjects after injection by the lumbar route, the average biological half-life measured by external counting lies between 20 and 28 hours. A study of the circulation of the C.S.F. is particularly useful in patients suspected of hydrocephalus. It permits finer diagnosis and shows the indication and type of by pass operation that may be necessary. An increase in the biological half-life of indium 111-DTPA seems to be a good indication for such an operation. An experience of 300 patients has shown the interest of the use of Indium 111-DTPA which now seems to be the best radio-isotope for the study of the subarachnoid space [fr

  5. Effect of calcium trisodium DTPA in rats with puncture wound contaminated by 90Y-chloride

    International Nuclear Information System (INIS)

    Watanabe, N.; Tanada, S.; Sasaki, Y.

    2005-01-01

    The efficacy of diethylenetriaminepentaacetate calcium trisodium (CaNa 3 DTPA) in a dose of 34.7 μmol kg -1 as a function of its route of administration was investigated in rats with a puncture wound contaminated by 90 Y-chloride at a concentration of 2.55 MBq kg -1 . Approximately 60% of 90 Y-chloride at a puncture wound was absorbed into the body of rats over 72 h post-puncture and radioactivity in femoral bone increased during the timed-release of 90 Y. Intravenous administration of CaNa 3 DTPA (systemic treatment) at 15 min post-puncture reduced 90 Y at a puncture wound and in bone up to 75.6 and 84.3% of controls, respectively. Direct infiltration of CaNa 3 DTPA into a puncture wound site (local treatment) at 15 min post-puncture diminished radioactivity at the puncture wound and in bone up to 34.9 and 52.5% of controls, respectively. Thus, prompt local treatment may be effective for removing 90 Y from a puncture wound and minimising 90 Y-distribution to bone compared with systemic treatment. (authors)

  6. Gd-DTPA: a bowel contrast agent for magnetic resonance imaging of the abdomen

    International Nuclear Information System (INIS)

    Vlahos, L.; Gouliamos, A.; Clauss, W.; Kalovidouris, A.; Hadjiioannou, A.; Athanasopoulou, A.; Trakadas, S.; Papavasiliou, C.

    1992-01-01

    Forty patients with suspected pathology in the abdomen and pelvis have been investigated with MRI before and after administration of Gd-DTPA as an oral or rectal solution. The findings are analysed with respect to: (a) filling of the GI tract; (b) contrast in the region of interest, surrounding fat and vessels; (c) diagnostic yield in comparison to non-enhanced MRI and contrast CT. At a concentration of 1 mmol/l Gd-DTPA provided consistent positive contrast in the stomach and bowel in all cases. In 57.5% of cases we achieved complete filling of the GI tract. The opacification in the region of interest was good or satisfactory in 90% of cases. The diagnostic value of contrast MRI was better in 93% of cases than the non-enhanced MRI of the abdomen. In comparison with contrast CT, the contrast MRI was better or of the same value in 92% of cases. Despite the disadvantage of poor fat-to-bowel contrast (35% of cases were classified as poor), it is concluded that Gd-DTPA-enhanced MRI provides good delineation of organs adjacent to the bowel so this contrast agent has potential for a future role in abdominal MRI. (orig.)

  7. Sonography and dynamic scintigraphy with 99mTc-DTPA in children with nephrotic syndrome

    International Nuclear Information System (INIS)

    Bliznakova, D.; Klisarove, A.

    2000-01-01

    The aim of the study is to assay the clinical application of kidney sonography and dynamic scintigraphy with 99m Tc-DTPA in children presenting nephrotic syndrome. A total of 32 children (mean age 9.5±1.2) are covered by the study, with the most important laboratory investigations being performed. All patients undergo abdominal sonography and dynamic kidney scintigraphy following iv administration of 100 μC/kg 99m Tc-DTPA, and glomerular filtration clarence (GFR) measured by the method of full and empty syringe activity. The functional curves are also shown. In children with primary nephrotic syndrome the sonographic imaging reveals enlarged kidney size and enhanced sonogeneity of parenchyma in the first stage. In patients with secondary nephrotic syndrome increased kidney size is likewise observed with enhanced sonogeneity of parenchyma in second stage and unclear visualization of pyramids. In children with idiopathic nephrotic syndrome the scintigraphic data confirm the enlarged kidneys with moderately increased values of GFR. In the mixed forms of nephrotic syndrome the kidneys preserve their moderate enlargement against the background of heterogeneous GFR values. In 5 patients the functional curves show kidney excretion impairment. The study confirms that sonographic imaging correlates well with the dynamic scintigraphic 99m Tc-DTPA imaging in children with nephrotic syndrome. The functional curves and GFR values promote accurate diagnosing and monitoring of the dynamic pathological processes. (author)

  8. Assessment of left ventricular hemodynamics by Gd-DTPA enhanced high speed cine MRI

    International Nuclear Information System (INIS)

    Matsumura, Kentaro; Nakase, Emiko; Kawai, Ichiro

    1992-01-01

    To assess the validity of Gd-DTPA enhanced high speed cine MRI in left ventricular (LV) volumes and ejection fraction (EF), high speed cine MRI was compared with intra-venous digital subtraction left ventriculography (IV-DSA) in 14 patients. All patients underwent conventional cine MRI and Gd-DTPA enhanced high speed MRI, simultaneously. The pulse sequences of high speed MRI were TR 8 ms (TR 6 ms plus rewind pulse 2 ms), TE 3.2 ms, matrix 128, phase encode 8 or 6 and NEX 1. Comparison with LV-volume showed a high correlation (y = 0.854x + 1,699, r = 0.985) between high speed cine MRI and VI-DSA. To make left ventricular volume curve by area-length method in cine MRI, manual tracing of LV-cavity was more difficult in conventional cine MRI-method than enhanced high speed cine MRI-method. In conclusion, first pass-Gd-DTPA enhanced high speed cine MRI, using the horizontal long axis approach and the multiphase study, is a highly, accurate reproducible method of evaluating LV-volumetry. (author)

  9. MR imaging of the cochlear modiolus after intratympanic administration of Gd-DTPA

    International Nuclear Information System (INIS)

    Kawai, Hisashi; Naganawa, Shinji; Ishihara, Shunichi; Sone, Michihiko; Nakashima, Tsutomu

    2010-01-01

    We evaluated whether enhancement of the cochlear modiolus could be visualized 24 hours after intratympanic injection of gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA) using a 3-dimensional real inversion recovery sequence combined with a 32-channel head coil at 3 tesla. Intratympanic injection of Gd-DTPA has been reported for visualizing endolymphatic hydrops in Meniere's disease, and its use has shown communication between the cochlear perilymph and cerebrospinal fluid in the internal auditory canal. Although the cochlear modiolus has been considered the route for this communication, this has not been confirmed through direct visualization of its enhancement. We qualitatively and quantitatively evaluated the presence of contrast enhancement in the modiolus in 19 patients with clinically suspected endolymphatic hydrops or hearing loss who underwent imaging as described above. The contrast ratio (CR) between the cochlear modiolus and cerebellar white matter on the injected side was 1.09±1.23, and that on the non-injected side was -0.48±0.38 (P<0.01). In all subjects, the CR value was larger on the injected than non-injected side, and enhancement of the cochlear modiolus was also recognized visually. Intratympanic Gd-DTPA can be administered to visualize enhancement of the cochlear modiolus and may thereby reveal its functional anatomy. (author)

  10. and O-based composite materials derived from differential ...

    Indian Academy of Sciences (India)

    available values. It was also observed that for each of these samples, Zeff was almost a constant at the three energies which unambiguously justified the conclusions drawn by other authors earlier [Manjunathaguru and ... with a personal computer-based multichannel analyzer. The counts under the peak were determined ...

  11. A tool to ascertain taxonomic relatedness based on features derived ...

    Indian Academy of Sciences (India)

    MADHU

    placements of a new isolate based on phenotypic characteristics are now being supported by information preserved in the 16S rRNA gene. ... were extracted from the training data set of the 16S rDNA sequence, and was subjected to an artificial neural network ..... variables to 275 principal components, accounting for 99%.

  12. Characterization of Schiff base derived from 2-hydroxo-1 ...

    African Journals Online (AJOL)

    Molar conductance measurements showed that the complex is non electrolyte with very high stability constant value. Gibb's free energy determination showed that the complex is very stable as shown in the high decomposition temperature measurements. Keywords: Potentiometry, Schiff base, Spectrophotometry, Stability ...

  13. synthesis of schiff bases derived from 2-hydroxy-1-naphth

    African Journals Online (AJOL)

    Amino acids have importance in Schiff base complexes formation in which these can act as ligands due to their physiological and pharmacological activities. ..... Aromatic carbon attached with azomethine Nitrogen. Aliphatic. Carbon. Aromatic carbon attached with azomethine Carbon. HNLH. 171.81. 158.84. 122.00. 40.33.

  14. Deriving tolerant grammars from a base-line grammar

    NARCIS (Netherlands)

    A.S. Klusener (Steven); R. Lämmel (Ralf)

    2003-01-01

    textabstractA grammar-based approach to tool development in re- and reverse engineering promises precise structure awareness, but it is problematic in two respects. Firstly, it is a considerable up-front investment to obtain a grammar for a relevant language or cocktail of languages. Existing work

  15. Measurement of Regional and Global Pulmonary Clearance of 99mTc-DTPA (Demethylamitriptylene-Acetate): An Index of Alveolar Epithelial Permeability

    International Nuclear Information System (INIS)

    Vaskova, Olivija

    1996-01-01

    The main purpose of this study has been introduction of a new method for alveoli-capillary permeability evaluation. Many reports pointed out to the altered transit of soluble particles through this barrier. From pathophysiological aspect the main interest is the elucidation of permeability's alteration in different pulmonary pathology. We decided to use for lung epithelial permeability measurements 99m Tc-DTPA inhaled aerosols and sequential assessment of its lung clearance. The aerosols were obtained using oxygen flow nebulizers with aerosols' generators Ultra Vent (Malinkrodt) and Venticis II (CIS bio international) that enabled as to get submicron particles. Oxygen flow between 9 and 11 liters per minute was used. Optimum images were obtained with 1480 MBq of inhaled aerosols at least 2 to 3 minutes. DTPA that was used for aerosols labeling had been produced in our Department and the results were compared with DTPA provided by CIS bio international. High correlation between both agents was proven. During the whole study ex tamper prepared radiopharmaceuticals were used and quality control was done using paper chromatography method. Acquisition was done in sitting position with gamma camera interfaced to a ADAC and Scintiview. The measurements lasted for 20 minutes. Data were stored on 64x64 matrices. Regions of interest over both lungs were drown and each one was divided in three segments: apical, medial, and basal. Using computer program curves of 99m Tc-DTPA lung clearance were derived. From the obtained time activity curves half-time of the global and the regional lung clearance was assessed. In the control group comprised of 32 healthy volunteers (non-smokers) we had got values, used after works as reference range. Our normal values for global clearance are: 68±5,5 min. for left whole lung, 68,1±6,5 min for right whole lung, and 49±7,7 min for apical, 66,9±8 min for middle, and 75,9±6,4 min basal regional lung clearance, and they are in keeping with the

  16. Analytical Derivation: An Epistemic Game for Solving Mathematically Based Physics Problems

    Science.gov (United States)

    Bajracharya, Rabindra R.; Thompson, John R.

    2016-01-01

    Problem solving, which often involves multiple steps, is an integral part of physics learning and teaching. Using the perspective of the epistemic game, we documented a specific game that is commonly pursued by students while solving mathematically based physics problems: the "analytical derivation" game. This game involves deriving an…

  17. Integrating ecological insight derived from individual-based simulations and physiologically structured population models

    NARCIS (Netherlands)

    Nisbet, R.M.; Martin, B.T.; de Roos, A.M.

    2016-01-01

    Two contrasting approaches are widely used to derive population dynamics as an emergent property deriving from the physiology and behavior of individual organisms. "Individual-based models" (IBMs) are computer simulations where the "state" (e.g., age, size) of each individual in a population is fol-

  18. Comparison of DTPA clearance, 24-hour urine collection and serum creatinine in estimating glomerular filtration rate (GFR)

    International Nuclear Information System (INIS)

    Pohlen, J.; Zein, H. El.; Babicheva, R.; Bell, A.; Dixson, H.; Penny, M.; Lee, K.

    2003-01-01

    Full text: A retrospective study was performed to compare 3 different methods of estimating GFR: DTPA clearance, 24-hour urine collection and serum creatinine using the Cockcroft-Gault equation. 40 patients (22 female, 18 male, mean age 61 (range 23-82) years) referred between 1997 and 2000 for DTPA renal scans and assessment of GFR were studied. The DTPA renal scan used an administered dose of 413-874MBq. Blood samples were drawn at 60 minutes and 150 minutes. Blood samples were centrifuged and two 1 ml aliquots of each sample were pipetted and counted in a Wallac well counter. A 3.7 kBq Cobalt 57 and technetium dilution standards were used to calibrate the well counter against the dose calibrator. Urinary 24-hour collections and serum creatinine levels were measured in a NATA accredited pathology laboratory. GFR estimated by DTPA clearance gave results in the range 42-168 ml/min/1.73m2. Analysis of GFR estimates normalised for body area for all 3 methods gave correlation coefficients of 0.79 for DTPA clearance vs serum creatinine, 0.72 for DTPA clearance vs 24- hour urine collection and 0.80 for 24-hour urine collection vs serum creatinine. The correlation was stronger for patients with impaired renal function and estimated GFR less than 80 ml/min/1.73m2 (r= 0.87, 0.86, 0.86 respectively). The DTPA clearance correlates well with other routine measurements used to estimate GFR. Copyright (2003) The Australian and New Zealand Society of Nuclear Medicine Inc

  19. High Speed Ultraviolet Phototransistors Based on an Ambipolar Fullerene Derivative

    KAUST Repository

    Huang, Wentao

    2018-03-13

    Combining high charge carrier mobility with ambipolar transport in light-absorbing organic semiconductors is highly desirable as it leads to enhanced charge photogeneration, and hence improved performance, in various optoelectronic devices including solar cells and photodetectors. Here we report the development of [6,6]-phenyl-C61-butyric acid methyl ester (PC61BM)-based ultraviolet (UV) phototransistors with balanced electron and hole transport characteristics. The latter is achieved by fine-tuning the source–drain electrode work function using a self-assembled monolayer. Opto/electrical characterization of as-prepared ambipolar PC61BM phototransistors reveals promising photoresponse, particularly in the UV-A region (315–400 nm), with a maximum photosensitivity and responsivity of 9 × 103 and 3 × 103 A/W, respectively. Finally, the temporal response of the PC61BM phototransistors is found to be high despite the long channel length (10 s of μm) with typical switching times of <2 ms.

  20. Novel Viologen Derivative Based Uranyl Coordination Polymers Featuring Photochromic Behaviors.

    Science.gov (United States)

    Hu, Kong-Qiu; Wu, Qun-Yan; Mei, Lei; Zhang, Xiao-Lin; Ma, Lei; Song, Gang; Chen, Di-Yun; Wang, Yi-Tong; Chai, Zhi-Fang; Shi, Wei-Qun

    2017-12-19

    A series of novel uranyl coordination polymers have been synthesized by hydrothermal reactions. Both complexes 1 and 2 prosess two ipbp - ligands (H 2 ipbpCl=1-(3,5-dicarboxyphenyl)-4,4'-bipyridinium chloride), one uranyl cation, and two coordination water molecules, which can further extend to 2D networks through hydrogen bonding. In complex 1, two sets of equivalent nets are entangled together, resulting in a 2D + 2D → 3D polycatenated framework. In complex 2, the neighbouring equivalent nets interpenetrate each other, forming a twofold interpenetrated network. Complexes 3 and 4 are isomers, and both of them are constructed from (UO 2 ) 2 (OH) 2 dinuclear units, which are connected with four ipbp - ligands. The 3D structures of complexes 3 and 4 are similar along the b axis. Similar to other viologen-based coordination polymers, complexes 3 and 4 exhibit photochromic and thermochromic properties, which are rarely observed in actinide coordination polymers. Unlike the monotonous coordination mode in complexes 1-4, the ipbp - ligands feature a μ 3 -bridge through two kinds of coordination modes in complex 5. Notably, complex 5 presents a unique example in which terminal pyridine nitrogen atom is involved in the coordination. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. A new Co (III) complex of Schiff base derivative for electrochemical ...

    Indian Academy of Sciences (India)

    (III) complex of Schiff base derivative for electrochemical recognition of nitrite anion. HAKAN YILMAZ ABDULKADIR KOCAK MAOWULIDAN DILIMULATI YUNUS ZORLU MUBERRA ANDAC. REGULAR ARTICLE Volume 129 Issue 10 October ...

  2. Development of ⁶⁸Ga-labelled DTPA galactosyl human serum albumin for liver function imaging.

    Science.gov (United States)

    Haubner, Roland; Vera, David R; Farshchi-Heydari, Salman; Helbok, Anna; Rangger, Christine; Putzer, Daniel; Virgolini, Irene J

    2013-08-01

    The hepatic asialoglycoprotein receptor is responsible for degradation of desialylated glycoproteins through receptor-mediated endocytosis. It has been shown that imaging of the receptor density using [(99m)Tc]diethylenetriamine pentaacetic acid (DTPA) galactosyl human serum albumin ([(99m)Tc]GSA) allows non-invasive determination of functional hepatocellular mass. Here we present the synthesis and evaluation of [(68)Ga]GSA for the potential use with positron emission tomography (PET). Labelling of GSA with (68)Ga was carried out using a fractionated elution protocol. For quality control thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC) and size exclusion chromatography (SEC) techniques were evaluated. Stability of [(68)Ga]GSA was studied in phosphate-buffered saline (PBS) and human serum. For in vivo evaluation [(68)Ga]GSA distribution in Lewis rats was compared with [(99m)Tc]GSA by using a dual isotope protocol. PET and planar imaging studies were performed using the same scaled molar dose of [(68)Ga]GSA and [(99m)Tc]GSA. Time-activity curves (TAC) for heart and liver were generated and corresponding parameters calculated (t50, t90). [(68)Ga]GSA can be produced with high radiochemical purity. The best TLC methods for determining potential free (68)Ga include 0.1 M sodium citrate as eluent. None of the TLC methods tested were able to determine potential colloids. This can be achieved by SEC. HPLC confirmed high radiochemical purity (>98%). Stability after 120 min incubation at 37 °C was high in PBS (>95% intact tracer) and low in human serum (∼27% intact tracer). Biodistribution studies simultaneously injecting both tracers showed comparable liver uptake, whereas activity concentration in blood was higher for [(68)Ga]GSA compared to [(99m)Tc]GSA. The [(99m)Tc]GSA TACs exhibited a small degree of hepatic metabolism compared to the [(68)Ga]GSA curves. The mean [(68)Ga]GSA t90 was higher than the mean t90 for [(99m)Tc]GSA. The mean

  3. Synthesis and enhanced neuroprotective activity of C60-based ebselen derivatives

    International Nuclear Information System (INIS)

    Liu, X.-F.; Guan, W.-C.; Ke, W.-S.

    2007-01-01

    A C 60 -based ebselen derivative 4 was synthesized through the cycloaddition of C 60 with the azide (3) containing the ebselen component. It was obtained in a four-step synthesis starting from 2-(chloroseleno)benzoyl chloride and 2-(2-aminoethoxy)ethanol in 53% yield (based on consumed C 60 ). Its structure was characterized by 1 H NMR, 13 C NMR, IR, UV, and FAB-MS. To verify that the C 60 -based ebselen derivative 4 had enhanced antioxidative and neuroprotective activity, the C 60 derivative 5 and the ebselen derivative 6 were selected to treat cortical neuronal cells using the same procedures as with the C 60 -based ebselen derivative 4. The cellular viability of different derivative treatment groups was estimated by LDH leakage assay and MTT assay. At the same final concentration (30 μmol/L), the results showed that the antioxidative and protective potencies of the C 60 -based ebselen derivative 4 (MTT (OD) 0.340 ± 0.035, LDH release (UL -1 ) 4.80 ± 0.16) against H 2 O 2 -mediated neuronal injury have an advantage over those of C 60 derivative 5 (MTT (OD) 0.297 ± 0.036, LDH release (UL -1 ) 5.37 ± 0.31) and ebselen derivative 6 (MTT (OD) 0.267 ± 0.027, LDH release (UL -1 ) 5.85 ± 0.26). Correspondingly, the GPX activity of 4 (1.62 U/μmol) was higher than that of 5 (0.77 U/μmol) and 6 (1.24 U/μmol). These findings demonstrate that the incorporation of two components with similar biological activity (C 60 component and ebselen component) may be a desirable way of obtaining a new and more biologically effective C 60 -based compound. (author)

  4. Pharmacokinetic analysis of Gd-DTPA enhancement in dynamic MR of breast carcinoma. Pharmakokinetische Analyse der Gd-DTPA-Anreicherung in der MRT beim Mammakarzinom

    Energy Technology Data Exchange (ETDEWEB)

    Hess, T. (Deutsches Krebsforschungszentrum, Heidelberg (Germany). Forschungsschwerpunkt Radiologische Diagnostik und Therapie); Knopp, M.V. (Deutsches Krebsforschungszentrum, Heidelberg (Germany). Forschungsschwerpunkt Radiologische Diagnostik und Therapie); Hoffmann, U. (Deutsches Krebsforschungszentrum, Heidelberg (Germany). Forschungsschwerpunkt Radiologische Diagnostik und Therapie); Brix, G. (Deutsches Krebsforschungszentrum, Heidelberg (Germany). Forschungsschwerpunkt Radiologische Diagnostik und Therapie); Junkermann, H. (Heidelberg Univ. (Germany). Abteilung fuer Gynaekologische Radiologie); Zuna, I. (Deutsches Krebsforschungszentrum, Heidelberg (Germany). Forschungsschwerpunkt Radiologische Diagnostik und Therapie); Fournier, D. von (Heidelberg Univ. (Germany). Abteilung fuer Gynaekologische Radiologie); Kaick, G. van (Deutsches Krebsforschungszentrum, Heidelberg (Germany). Forschungsschwerpunkt Radiologische Diagnostik und Therapie)

    1994-06-01

    Dynamic Gd-DTPA enhanced MR of the breast was performed in one single slice in 27 patients with suspicious nodular lesions. The results could be histologically verified in all cases. A rapid spin-echo sequence with a time resolution of 8.75 s was used for the dynamic examination. The signal changes were analysed using a pharmacokinetic model which allowed parametrization of the contrast enhancement and transformation of the data into colour coded parameter images. The parameters allowed reliable distinction of 9 benign from 18 malignant lesions (p<0.05 for ''amplitude'', p<0.001 for ''k[sub 21]''). One fibroadenoma could not be distinguished from the carcinomas. Lymph node metastases and the pharmacokinetic parameter amplitude correlated significantly (p<0.05). (orig.)

  5. The exploratory development of A self-made oral Gd-DTPA solution for low field MRCP in children

    International Nuclear Information System (INIS)

    Sheng Mao; Zhou Min; Gu Zhicheng; Wu Jizhi; Guo Wanliang; Ni Yongbiao; Fang Lin

    2010-01-01

    Objective: To evaluate the value of ingestion self-made Gd-DTPA solutin for low field magnetic resonance cholangiopancreatography (MRCP) (0.35T) in children. Methods: Phantom experiments were performed to select the optimal concentration of Gd-DTPA to be used as an oral negative contrast agent in low field MRCP. Twenty children suspected of celiac disease were performed with MRCP before and after ingestion Gd-DTPA solution. Signal intensity measurements of gastroduodenal lumens, pancreatobiliary ducts, and image quality scores were obtained systematically before and after contrast ingestion. Results: The selected Gd-DTPA concentration was 1.992 mmol/L. Ingestion of 80 ml solution eliminated or suppressed efficiently the gastroduodenal signal intensity, improving the MRCP image quality scores (P<0.01) significantly in children. Conclusion: 1.992 mmol/L self-made Gd-DTPA solutin can suppress or eliminate water signals from gastrointestinal tract and improve the quality of low field MRCP image in children. (authors)

  6. Value of Tc99m-DTPA alveolar permeability in lung involvement detection of patients with HIV infection

    International Nuclear Information System (INIS)

    Massardo Vega, Teresa; Jofre Manieu, Maria Josefina; Cabello Araya, Hernan; Sepulveda Carvajal, Cecilia; Ruiz Carmona, Mauricio; Moyano Schlegel, Leonor; Fica Cubillos, Alberto; Alay Perez, Rita

    2001-01-01

    We studied 35 HIV patients in order to know the value of Tc99mDTPA in the assessment of pulmonary lung involvement, especially pneumocystis carinii (PC) infection. Lung DTPA clearance measures increased alveolar permeability. Twenty patients with respiratory symptoms were included, 4 with systemic symptoms and also 11 asymptomatics, with similar immune condition (CD4 lymphocytes <400) as a control group. Smoking habit was suspended prior the test. Clinical follow up, chest film, induced sputum and/or fibrobronchoscopy were obtained. There was histological confirmation of PC presence or absence in 16 symptomatics and 3 asymptomatics. DTPA sensitivity for PC detection was 78%, specificity 40% and accuracy 58%; the values were 85%, 60% and 79%, respectively, for inflammatory lung processes. There were 4/6 cases false positive for PC detection with respiratory features explaining DTPA abnormalities. Concluding, Tc99m-DTPA is sensitive but not specific for detecting PC pneumonia but its value is higher for pulmonary inflammatory processes (Au)

  7. Solid dispersions of the penta-ethyl ester prodrug of diethylenetriaminepentaacetic acid (DTPA): formulation design and optimization studies.

    Science.gov (United States)

    Yang, Yu-Tsai; Di Pasqua, Anthony J; Zhang, Yong; Sueda, Katsuhiko; Jay, Michael

    2014-11-01

    The penta-ethyl ester prodrug of diethylenetriaminepentaacetic acid (DTPA), which exists as an oily liquid, was incorporated into a solid dispersion for oral administration by the solvent evaporation method using blends of polyvinylpyrrolidone (PVP), Eudragit® RL PO and α-tocopherol. D-optimal mixture design was used to optimize the formulation. Formulations that had a high concentration of both Eudragit® RL PO and α-tocopherol exhibited low water absorption and enhanced stability of the DTPA prodrug. Physicochemical properties of the optimal formulation were evaluated using Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). In vitro release of the prodrug was evaluated using the USP Type II apparatus dissolution method. DSC studies indicated that the matrix had an amorphous structure, while FTIR spectrometry showed that DTPA penta-ethyl ester and excipients did not react with each other during formation of the solid dispersion. Dissolution testing showed that the optimized solid dispersion exhibited a prolonged release profile, which could potentially result in a sustained delivery of DTPA penta-ethyl to enhance bioavailability. In conclusion, DTPA penta-ethyl ester was successfully incorporated into a solid matrix with high drug loading and improved stability compared to prodrug alone.

  8. Solid dispersions of the penta-ethyl ester prodrug of diethylenetriaminepentaacetic acid (DTPA): Formulation design and optimization studies

    Science.gov (United States)

    Yang, Yu-Tsai; Di Pasqua, Anthony J.; Zhang, Yong; Sueda, Katsuhiko; Jay, Michael

    2015-01-01

    The penta-ethyl ester prodrug of diethylenetriaminepentaacetic acid (DTPA), which exists as an oily liquid, was incorporated into a solid dispersion for oral administration by the solvent evaporation method using blends of polyvinylpyrrolidone (PVP), Eudragit® RL PO and α-tocopherol. D-optimal mixture design was used to optimize the formulation. Formulations that had a high concentration of both Eudragit® RL PO and α-tocopherol exhibited low water absorption and enhanced stability of the DTPA prodrug. Physicochemical properties of the optimal formulation were evaluated using Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). In vitro release of the prodrug was evaluated using the USP Type II apparatus dissolution method. DSC studies indicated that the matrix had an amorphous structure, while FTIR spectrometry showed that DTPA penta-ethyl ester and excipients did not react with each other during formation of the solid dispersion.. Dissolution testing showed that the optimized solid dispersion exhibited a prolonged release profile, which could potentially result in a sustained delivery of DTPA penta-ethyl to enhance bioavailability. In conclusion, DTPA penta-ethyl ester was successfully incorporated into a solid matrix with high drug loading and improved stability compared to prodrug alone. PMID:24047113

  9. Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino rats

    Directory of Open Access Journals (Sweden)

    Hasan Zora

    2011-09-01

    Full Text Available In recent years all over the world, medicinal plants are used quite a lot but side effects of biological and chemical contents and radiopharmaceutical interactions for each consumer in question aren't entirely well-known. The studies of plant origin drug interaction with radiopharmaceuticals are highly relevant and desired. One of them is passiflora syrup (Passiflora incarnata L., Passifloraceae which is widely used for depression, insomnia, anxiety and menopause period. The aim of current study is to evaluate possible effects of passiflora syrup on the biodistribution of 99mTc-DTPA and its blood cells uptake. DTPA was labeled with 99mTc radionuclide. Biodistribution studies were performed on male Wistar albino rats which were treated via oral feeding-gavage-method with either passiflora syrup or 0.9 % NaCl as control group for ten days. Blood samples were obtained by cardiac blood withdrawal from the rats and they were radiolabeled. The biodistribution results showed that the passiflora syrup decreased the uptake of 99mTc-DTPA in kidneys and in blood cells. 99mTc-DTPA being used widely as a kidney diagnostic agent in nuclear medicine seems to be interacting with orally taken passiflora. Passiflora syrup may modify the uptake of 99mTc-DTPA by kidney. The knowledge of this negative effect may contribute to reduce the risk of misdiagnosis and/or repetition of the examinations in nuclear medicine.

  10. Detection of diffuse glomerular lesions in rats: II. Comparison of indium-111 cationic small macromolecules with technetium-99m DTPA

    International Nuclear Information System (INIS)

    McAfee, J.G.; Thomas, F.D.; Subramanian, G.; Schneider, R.D.; Lyons, B.; Roskopf, M.; Zapf-Longo, C.; Whaley, D.

    1986-01-01

    Dextrans with average molecular weights of 5000, 10,000, and 17,500 and inulin were rendered cationic by amination with 2-bromoethylamine hydrobromide. After limited coupling with DTPA cyclic dianhydride, they were labeled with 111In. A good correlation was found between their early renal uptake quantitated by camera-computer techniques and their renal clearance from multiple plasma samples in rats with glomerular damage induced by puromycin aminonucleoside and controls. However, there was poor correlation between the early renal uptake of these agents and the clearance of simultaneously injected [/sup 99m/Tc]DTPA. The 2-hr organ distribution and urinary excretion of these agents were compared with the corresponding values of DTPA. The differences in clearance between rats with glomerular damage and controls were greater with aminated dextran (mol wt 5000) than with DTPA, confirming previous work with infusions of nonradioactive charged dextrans and neutral inulin. The cationic dextrans appear to reflect the presence or absence of the normal anionic charge of the glomerular membrane as well as changes in filtration rate. Aminated inulin did not differentiate between controls and rats with glomerular disease any better than DTPA, probably because the number of amino groups conjugated was insufficient to produce the charge effect

  11. Evaluating coronary reperfusion during acute myocardial infarction in a canine model by gadolinium-DTPA-enhanced magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Tanabe, Kazuaki; Ishibashi, Yutaka; Shimada, Toshio (Shimane Medical Univ., Izumo (Japan)) (and others)

    1993-05-01

    In previous studies, magnetic resonance imaging (MRI) using contrast agents was found to be useful in distinguishing reperfused infarcts from nonreperfused infarcts. However, there have been only a few detailed studies using consecutive MR images for the assessment of myocardial reperfusion during an acute infarction and also no studies have been performed using a percutaneous transluminal coronary occlusion model (closed chest model). We induced acute myocardial infarction in dogs by occluding and then reperfusing the coronary artery with a balloon catheter. ECG-gated MR images were taken using the spin-echo technique before and after Gd-DTPA injection during both coronary artery occlusion and after reperfusion. We defined the intensity ratio (IR) as the signal intensity at the ischemic area divided by that at the nonischemic area on MR images and compared each image by the IR. Without Gd-DTPA, there was no difference between infarcted and normally perfused myocardium. Infarcted myocardium had a low signal intensity (IR=0.68[+-]0.14) soon after Gd-DTPA injection. This difference diminished with time. After reperfusion the infarcted myocardium had a high signal intensity (IR: 1.76[+-]0.34). We conclude that Gd-DTPA-enhanced MRI can distinguish reperfused from nonreperfused infarcts soon after Gd-DTPA administration. (author).

  12. Removal of 54Mn from the mouse body by dilution with stable manganese and by chelation with DTPA

    International Nuclear Information System (INIS)

    Sato, Itaru; Matsusaka, Naonori; Tsuda, Shuji

    1999-01-01

    54 Mn is one of the activation products generated in nuclear reactors. This study was carried out to find a method appropriate for the removal of 54 Mn. Intraperitoneal administration of stable manganese effectively promoted the excretion of 54 Mn from the mouse body. The efficacy for removing 54 Mn was estimated to be 56, 67, 77 and 82% for manganese doses of 0.3, 1, 3 and 10 mg/kg, respectively. Oral administration of stable manganese was also effective for the removal of 54 Mn, but the efficacy was inferior to that obtained by intraperitoneal administration because of low gastrointestinal absorption of manganese. Ca-DTPA and Zn-DTPA promoted the excretion of 54 Mn when administered 1 h after administration of 54 Mn, but these chelating agents had little effect when administered after 3 h or more. Zn-DTPA was less effective than Ca-DTPA. These results demonstrate that dilution with stable manganese is more effective than chelation with DTPA for the removal of 54 Mn from the body. (author)

  13. Clinical phase II study with Gd-DTPA (dimeglumine gadopentetate, SHL 451 A) in brain tumor and cerebral infarction

    Energy Technology Data Exchange (ETDEWEB)

    Yoshikawa, Kohki; Aoki, Shigeki; Machida, Tohru and others

    1988-06-01

    A clinical phase II study with Gd-DTPA, the first contrast medium for MRI, was performed in 109 cases, a total of 114 studies mainly with brain tumor. In this study, one of the three concentrations of Gd-DTPA, 0.05 mmol/kg, 0.10 mmol/kg or 0.15 mmol/kg was used in each patient. It was elucidated that especially 0.10 and 0.15 Gd-DTPA were useful in detecting disruption or abscence of BBB and distinguishing tumor from edema. The side-effect observed was only a slight urticaria which was seen with 0.15 mmol/kg Gd-DTPA. Accordingly, it was estimated that the standard concentration of Gd-DTPA would be 0.10 mmol/kg. As this contrast medium was safe, and clinically useful in detecting diseases of the central nervous system, it was concluded that the shift to the clinical phase III trial is possible.

  14. Hepatocyte transporters related to the uptake and excretion of Gd-EOB-DTPA

    International Nuclear Information System (INIS)

    Kitao, Azusa; Zen, Yoh; Gabata, Toshifumi

    2010-01-01

    Gadolinium-ethoxybenzyl-diethylene-triamine-pentaacetic acid (Gd-EOB-DTPA, Primovist) is a recently developed hepatobiliary-specific contrast material for magnetic resonance imaging (MRI). Gd-EOB-DTPA is taken up by hepatocytes and then excreted into the bile ducts in normal liver. Hepatic focal lesions with abnormal hepatobiliary function can be definitely depicted compared to background liver on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MR imaging (EOB-MRI). The enhancement ratio on EOB-MRI would reflect the balance of the uptake and excretion function of the lesions. In a rat experimental study, the hepatic uptake transporter of Gd-EOB-DTPA was confirmed to be an organic anion transporting polypeptide 1 (Oatp1), and the export transporter was multidrug resistance-associated protein 2 (Mrp2). The substrates transported by rat oatp1 can be taken up by human OATP1B1, OATP1B3 and OATP2B1, which are expressed on the sinusoidal side of hepatocytes. The substrates of rat Mrp2 can be exported by MRP2 on the canalicular side and MRP1/MRP3 on the sinusoidal side of human hepatocytes. Those transporters carry many kinds of intrinsic or extrinsic molecules, for example bilirubin glucuronides, bile acids, hormones and several drugs. Some of these transporters should be involved in the uptake and excretion of Gd-EOB-DTPA in human normal hepatocytes and tumor cells. During the hepatobiliary phase of EOB-MRI, most hepatocellular carcinomas (HCCs) classically show a low enhancement ratio, but a high enhancement ratio is shown in several percent of lesions. We analyzed the expression of uptake and excretion transporters (OATPs and MRPs) in HCCs correlated with the signal intensity on the hepatobiliary phase of EOB-MRI. As a result, the expressions of uptake transporter OATP1B3 and sinusoidal excretion transporter MRP3 significantly increased in hyperintense HCCs compared to hypointense HCCs. Therefore, we thought OATP1B3 and MRP3 (not canalicular transporter MRP2) are the

  15. Changes in gadolinium-DTPA enhanced magnetic resonance signal intensity ratio in hypertrophic cardiomyopathy

    Energy Technology Data Exchange (ETDEWEB)

    Tsukihashi, Hironori; Ishibashi, Yutaka; Shimada, Toshio; Hatano, Jun; Tanabe, Kazuaki; Ooyake, Nobuyuki; Morioka, Shigefumi; Moriyama, Katsutoshi (Shimane Medical Univ., Izumo (Japan))

    Serial gadolinium-diethylene-triamine-pentaacetic acid (Gd-DTPA) enhanced magnetic resonance (MR) signal intensity ratios were measured in 6 normal subjects and 20 hypertrophic cardiomyopathy (HCM) patients to try to differentiate normal from disorganized myocardial tissue. Images were obtained at 10-minute intervals 5-60 minutes after Gd-DTPA (0.1 mmol/kg) injection. The signal intensity ratio (myocardial signal intensity/skeletal muscle signal intensity) was measured at both hypertrophic and non-hypertrophic regions in each image at the apex and mid-ventricular levels. The signal intensity ratio was standardized to compare each case. Hypertrophic myocardium was classified into two types. Type I in 11 of 20 patients was visualized as a homogeneous image, while type II in the other 9 patients was revealed as a mixed isointensity and high intensity area. The peak value of the standardized signal intensity ratio at the apex level was 1.28[+-]0.09 in HCM patients and 1.23[+-]0.06 in normal subjects, and at the mid ventricular level was 1.26[+-]0.07 in hypertrophic regions, 1.17[+-]0.12 in non-hypertrophic regions, and 1.16[+-]0.07 in normal subjects. Thirty minutes after Gd injection, the standardized signal intensity ratio at the apex level was 1.21[+-]0.08 in HCM patients and 1.07[+-]0.08 in normal subjects, and those at the mid ventricular level was 1.20[+-]0.09 in hypertrophic regions, 1.11[+-]0.11 in non-hypertrophic regions, and 1.04[+-]0.06 in normal subjects. The delayed decay of the signal intensity ratio and high signal intensity ratio in Gd-DTPA enhanced MR images are useful in myocardial tissue characterization in hypertrophic cardiomyopathy. (author).

  16. Evaluation of Renal Function in Children by Tc-99m DTPA Scintigraphy

    Directory of Open Access Journals (Sweden)

    Sevin Ayaz

    2016-09-01

    Full Text Available Aim: Dynamic renal scintigraphy can demonstrate both structural and functional renal pathologies. Our aim was to evaluate renal functions in children by technetium-99m diethylenetriaminepentaacetic acid (Tc-99m DTPA dynamic renal scintigraphy, and todetermine the frequency of scintigraphically detectable atrophic kidneys. Material and Method: Dynamic renal scintigraphy studies of 17 children (12 males, five females with urinary system complaints, having a mean age of 6.15 ± 4.41 years, were included in this retrospective study. Images were obtained with a dual-head gamma camera after intravenous (IV injection of Tc-99m DTPA. Results: The functions of 34 kidneys were evaluated. Decreased perfusion of the left and right kidneys was detected in 35.3% (n=6/17 and 11.8% (n=2/17 of cases, respectively. Prolongation in Tmax of the left and right kidneys was shown in 52.9% (n=9/17 and 29.4% (n=5/17 of the cases, respectively. Glomerular filtration rate of the left and right kidneys was normal in 64.7% (n=11/17 and 88.2% (n=15/17 of cases, respectively. Delayed excretion of the left and right kidneys wasdetected in 29.4% (n=5/17 and 11.8% (n=2/17 of cases, respectively. Stasis of urine in the left and right kidneys which responded to IV diuretics wasdemonstrated in 58.8% (n=10/17 and 70.6% (n=12/17 of cases, respectively. Dynamic renal scintigraphy findings in favour of left and right renal atrophy were obtained in 17.6% (n=3/17 and 5.9% (n=1/17 of cases, respectively. Discussion: Dynamic renal scintigraphy with Tc-99m DTPA was found to be useful in the evaluation of renal functions of children and in determining the frequency of atrophic kidneys.

  17. Lung clearance of 99m Tc- DTPA in systemic lupus erythematous

    International Nuclear Information System (INIS)

    Dalcin, P.T.R; Barreto, S.S.M.; Xavier, R.M.; Brenol, J.C.T.; Cunha, R.D.; Marroni, B.J.

    2002-01-01

    The early demonstration of lung involvement in systemic lupus erythematosus (SLE) patients is a difficult but important task. In the present study we attempted to identify abnormalities in pulmonary clearance of 99 mTc-DTPA in SLE, correlating their clearance data with clinical findings and disease activity. Forty-six consecutive SLE patients with and without active disease (LACC score) and 30 normal volunteers were studied. All subjects were submitted to pulmonary scintigraphy with 99 mTc-DTPA to evaluate the pulmonary clearance, and to a chest X-ray, and SLE patients were submitted to tests of disease activity, spirometry, arterial blood gases and tests to assess acute-phase proteins. Pulmonary clearance was faster in SLE patients with active disease when compared to normal controls [half-life of 67.04 min (51.52-82.55 min) in active SLE versus 85.87 min (78.85-92.87 min) in controls, P<0.05] and there was a higher frequency of abnormal clearance rates in patients with active disease (11 of 26 patients, 42.3%) when compared with SLE patients without disease activity (2 of 20 patients, 10%) (P = 0.04). A significant correlation was observed between the clearance rates and cough (P<0.05), but not between the clearance rates and dyspnoea symptoms or radiological findings, duration of SLE disease, antinuclear antibody titers and patterns, C-reactive protein or anti-double stranded DNA antibodies. We conclude that the pulmonary clearance of 99 m Tc-DTPA is increased in SLE patients with active disease. (author)

  18. Lung clearance of {sup 99m} Tc- DTPA in systemic lupus erythematous

    Energy Technology Data Exchange (ETDEWEB)

    Dalcin, P.T.R; Barreto, S.S.M.; Xavier, R.M.; Brenol, J.C.T. [Rio Grande do Sul Univ., Porto Alegre, RS (Brazil). Hospital de Clinicas. Dept. de Medicina Interna; Cunha, R.D.; Marroni, B.J. [Rio Grande do Sul Univ., Porto Alegre, RS (Brazil). Hospital de Clinicas. Servico de Medicina Nuclear]. E-mail: rxavier@hcpa.ufrgs.br

    2002-06-01

    The early demonstration of lung involvement in systemic lupus erythematosus (SLE) patients is a difficult but important task. In the present study we attempted to identify abnormalities in pulmonary clearance of 99 mTc-DTPA in SLE, correlating their clearance data with clinical findings and disease activity. Forty-six consecutive SLE patients with and without active disease (LACC score) and 30 normal volunteers were studied. All subjects were submitted to pulmonary scintigraphy with 99 mTc-DTPA to evaluate the pulmonary clearance, and to a chest X-ray, and SLE patients were submitted to tests of disease activity, spirometry, arterial blood gases and tests to assess acute-phase proteins. Pulmonary clearance was faster in SLE patients with active disease when compared to normal controls [half-life of 67.04 min (51.52-82.55 min) in active SLE versus 85.87 min (78.85-92.87 min) in controls, P<0.05] and there was a higher frequency of abnormal clearance rates in patients with active disease (11 of 26 patients, 42.3%) when compared with SLE patients without disease activity (2 of 20 patients, 10%) (P = 0.04). A significant correlation was observed between the clearance rates and cough (P<0.05), but not between the clearance rates and dyspnoea symptoms or radiological findings, duration of SLE disease, antinuclear antibody titers and patterns, C-reactive protein or anti-double stranded DNA antibodies. We conclude that the pulmonary clearance of 99 m Tc-DTPA is increased in SLE patients with active disease. (author)

  19. Technetium-99m DTPA inhalation scintigraphy in patients treated with fluoxetine and maprotiline: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Kaya, G.C.; Durak, H.; Oezdogan, Oe.; Sayit, E.; Degirmenci, B.; Derebek, E. [Dokuz Eyluel Univ., Izmir (Turkey). School of Medicine; Yemez, B.; Turhal, Ue. [Dept. of Psychiatry, Dokuz Eylul Univ. School of Medicine, Izmir (Turkey)

    2000-09-01

    Drug-metabolising enzymatic activities have been detected in tracheobronchiolar, bronchiolar and alveolar regions in the lungs. Induction of phospholipidosis by amine drugs such as clorphentermine has also been shown. This study aimed to investigate the effect of fluoxetine and maprotiline, which contain amine groups in their structure, on pulmonary epithelial membrane permeability. Twenty-seven patients (mean age 36{+-}12 years) with various psychiatric problems, of whom 17 were treated with fluoxetine and 10 with maprotiline, were included in this study. Technetium-99m diethylene triamine penta-acetic acid (DTPA) aerosol inhalation scintigraphy was performed before and after 4-6 weeks of therapy. Following the inhalation of 1480 MBq {sup 99m}Tc-DTPA for 3 min, lung images in a 64 x 64 matrix were obtained every minute for 30 min. Regions of interest were drawn around the periphery of the lungs and on the major airways. Clearance half-times (T{sub 1/2}) were calculated by placing a mono-exponential fit on the curves. Penetration index (PI) was calculated on the first-minute image. There was no difference between the clearance rates of {sup 99m}Tc-DTPA before and after therapy for either the fluoxetine or the maprotiline group. After therapy, a significant decrease in PI was found in patients treated with fluoxetine (PI values before and after therapy: 0.53{+-}0.03 and 0.49{+-}0.05 respectively, P{<=}0.05). This finding might have been due to the induction of increased synaptic serotonin (5-HT) by fluoxetine, which acts by inhibiting the re-uptake of 5-HT on presynaptic membranes. Bronchoconstriction of small and medium airways may be caused by direct and indirect effects of 5-HT on smooth muscle contraction. (orig.)

  20. Determination of separate kidney clearance by means of the Tc-DTPA complex and the scintillation camera

    International Nuclear Information System (INIS)

    Piepsz, A.; Dobbeleir, A.; Erbsmann, F.

    1975-01-01

    A new quantitative method to determine the separate kidney is described. This method is based on the use of the Tc-DTPA complex administered in a single intraveinous injection, a scintillation camera and continuous computerized data recording for 20 minutes at 20 sec. intervals. By definition the slope of the kidney radioactivity curve, divided by the corresponding plasma concentration, represents at each instant the glomerular clearance of the kidney. This only applies before the 3rd minute following the intraveinous tracer injection, when the filtered radioactivity has not yet left the kidney area. Between the 60th and 180th sec., 6 clearance values may be determined for each kidney. For each 20-sec. time interval the renal activity increase per minute is divided by the plasma concentration during the same interval and the average of these values is taken as the glomerular clearance figure. Some results have been analysed. The test could end 3 min. after the intraveinous injection. Continuation of the recording for 20 min. gives a complete dynamic picture of the kidney function [fr

  1. Estimating glomerular filtration rate in oncology patients receiving Cisplatin chemotherapy: Predicted creatinine clearance against 99mTc-DTPA methods

    Science.gov (United States)

    Khaidah Syed Sahab, Sharifah; Manap, Mahayuddin; Hamzah, Fadzilah

    2017-05-01

    The therapeutic potential of cisplatin as the best anticancer treatment for solid tumor is limited by its potential nephrotoxicity. This study analyses the incidence of cisplatin induced nephrotoxicity in oncology patients through GFR estimation using 99mTc-DTPA plasma sampling (reference method) and to compare with predicted creatinine clearance and Tc-99m renal scintigraphy. A prospective study of 33 oncology patients referred for GFR estimation in Penang Hospital. The incidence of cisplatin induced nephrotoxicity was analysed via radionuclide and creatinine based method. Of 33 samples, only 21 selected for the study. The dose of cisplatin given was 75 mg/m2 for each cycle. The mean difference of GFR pre and post chemotherapy (PSC 2) was 13.38 (-4.60, 31.36) ml/min/1.73m2 (p 0.136). Of 21 patients, 3 developed severe nephrotoxicity (GFR cisplatin chemotherapy. This percentage is much less than the reported 20 - 25% of cases from other studies, probably due to small sample size and biased study population due to strict exclusion criteria. Radionuclide method for evaluating GFR is the most sensitive method for the detection of cisplatin induced nephrotoxicity by showing 3 of 21 patients developing severe nephrotoxicity. PSC 1 was found to be a reliable substitute of PSC 2. The other methods are not reliable for detection of early nephrotoxicity. We will recommend the use of single plasma sampling method (PSC 1) for GFR estimation in monitoring post cisplatin chemotherapy patients.

  2. Glomerular filtration rate in transplantation patients: estimation of renal function using Tc-99m DTPA

    International Nuclear Information System (INIS)

    Reinig, J.W.; Gordon, L.; Frey, D.; Garrick, E.; Daniel, W.T. III

    1985-01-01

    The clinical assessment of a transplanted kidney is often difficult, especially in the immediate postoperative period. The biochemical parameters used to monitor renal function change slowly and can take several days to reflect the actual renal status. The authors have modified a technique for determining the glomerular filtration rate (GFR) from a Tc-99m DTPA renal scan and have found that it correlates with the actual GFR throughout the postoperative course. In addition, they describe a method for changing dose calibrator measurements into administered counts. This technique for determining the GFR provides a quick and accurate assessment of renal function and is useful to guide therapeutic decisions

  3. Glomerular filtration rate in children: determination from the Tc-99m-DTPA renogram

    International Nuclear Information System (INIS)

    Shore, R.M.; Koff, S.A.; Mentser, M.; Hayes, J.R.; Smith, S.P.; Smith, J.P.; Chesney, R.W.

    1984-01-01

    Analysis of the Tc-99m-DTPA renogram is usually limited to calculating the relative function of each kidney. To develop a method to determine the absolute glomerular filtration rate (GFR), various methods of analyzing the renogram were examined to determine which gave the best correlation with GFR. That regression could then be used to predict GFR without the need for blood samples. Fifty children were studied using Tc-99m-DPTA renograms and GFR measured simultaneously by plasma disappearance. GFR correlated better with the slope of the second phase than with the area under the renogram curve. This method can accurately estimate GFR from the renogram in children

  4. Gastrointestinal scintigraphy with 99mTc-DTPA labeled tablets in fed and fasting subjects

    International Nuclear Information System (INIS)

    Maublant, J.C.; Veyre, A.; Sournac, M.; Aiache, J.M.

    1989-01-01

    The in vitro and in vivo dissolution of a sustained release theophylline formulation labeled with 99m Tc-diethyltriaminepentaacetic acid (DTPA) has been monitored in six subjects with a scintillation camera. The study was performed in fasting conditions and was repeated after ingestion of a standardized meal. Results showed that the presence of food in the stomach dramatically increased the oesoduodenal transit time of the tablet (74±27 min vs 352±77 min, P<0.001) but did not modify the biodisponibility of theophylline. This study is another example when scintigraphy can be of definite value in pharmacokinetics. (orig.)

  5. Gastrointestinal scintigraphy with /sup 99m/Tc-DTPA labeled tablets in fed and fasting subjects

    Energy Technology Data Exchange (ETDEWEB)

    Maublant, J.C.; Veyre, A.; Sournac, M.; Aiache, J.M.

    1989-03-01

    The in vitro and in vivo dissolution of a sustained release theophylline formulation labeled with /sup 99m/Tc-diethyltriaminepentaacetic acid (DTPA) has been monitored in six subjects with a scintillation camera. The study was performed in fasting conditions and was repeated after ingestion of a standardized meal. Results showed that the presence of food in the stomach dramatically increased the oesoduodenal transit time of the tablet (74+-27 min vs 352+-77 min, P<0.001) but did not modify the biodisponibility of theophylline. This study is another example when scintigraphy can be of definite value in pharmacokinetics.

  6. Radiolabelling of antibodies with indium: Use of diethylenetriaminepentaacetic acid (DTPA) as chelating agent

    International Nuclear Information System (INIS)

    Loetscher, H.

    1986-01-01

    /sup 111/In/sup 3+/ was used to radiolabel the F(ab')/sub 2/ fragment of a monoclonal antibody (b-12) raised against a surface antigen of a mammalian breast tumor cell line (5). The in vivo distribution of the radiolabel was analyzed in mice bearing a transplant of fixed tumor cells in the left thigh. The results demonstrate that DTPA can be efficiently coupled to a tumor specific F(ab')/sub 2/ fragment and loaded with /sup 111/In/sup 3+/ yielding a stable, highly labelled complex

  7. MR imaging with Gd-DTPA in tumors of the larynx and hypopharynx

    International Nuclear Information System (INIS)

    Vogl, T.J.; Steger, W.; Grevers, G.; Schedel, H.; Lissner, J.

    1990-01-01

    This paper reports on 31 patients with tumors of the larynx and hyupopharynx, the results of preoperative MR imaging were correlated with clinical laryngoscopic findings and the pathologic tumor classification. MR examinations were performed at 1.0 T with T1-weighted and T2-weighted spin-echo sequences. Laryngeal tumors, hypopharyngeal tumors, laryngoceles, and amyloid and inflammatory structures were found. In laryngeal lesions, transverse and coronal sections proved helpful; in hypopharyngeal expansions, transverse and sagittal sections were preferred. The most accurate diagnostic findings were achieved with Gd-DTPA-enhanced images, and subtraction technique enabled exact judgment of deep infiltration

  8. Enhanced removal of 241Am by DTPA chelation therapy in an adult and teenage subject

    International Nuclear Information System (INIS)

    Sasso, T.L.; Cohen, N.

    1975-01-01

    A series of Na 3 (Ca-DTPA) chelation treatments were carried out on two human subjects, an adult man and a teenage boy, who have long-term body burdens of 241 Am. The in vivo whole-body counting, bioassay of urine and feces, and various blood chemistry measurements were coordinated to coincide with this therapy schedule. Decreases in total body burdens for this treatment period were measured as 5 percent in the adult and 30 percent in the youth. High concentrations of zinc in urine and a corresponding decrease of activity of the zinc-dependent erythropoietic enzyme, ALAD, were also observed. (U.S.)

  9. Assessment of individual renal function in children using sup(99m)Tc-DTPA

    International Nuclear Information System (INIS)

    Kainer, G.; Mcilveen, B.; Hoeschl, R.; Rosenberg, A.R.

    1979-01-01

    Differential renal function assessment using technetium-labelled stannous diethylenetriaminepentaacetic acid (sup(99m)Tc-DTPA) was carried out in 12 children aged between 3 weeks and 11 years who had undergone surgical procedures which allowed separate access to the urine output from each kidney. The results correlated well with those obtained by measuring individual kidney creatinine clearances. The best result was obtained using the technique of deconvolution analysis (r = 0.98; P < 0.001). It was concluded that the method is accurate and its use is recommended in the management and follow-up of patients with asymmetric renal disease. (author)

  10. New perspective for GdNCT. Gd-DTPA reaches the nucleus of glioblastoma cells in culture and in vivo

    International Nuclear Information System (INIS)

    Stasio, G. de; Gilbert, B.; Frazer, B.H.

    2000-01-01

    We investigated the prospects of gadolinium as a neutron capture therapy agent by combining three independent techniques to study the uptake of Gd-DTPA in vitro, in cultured glioblastoma cells, and in vivo, in the glioblastoma tissue sections after injection of Gd-DTPA and tumor extraction. We show that gadolinium not only penetrates the plasma membrane of glioblastoma cells grown in culture, but we also observe a statistically significant higher concentration of Gd in the nucleus relative to the cytoplasm. For the in vivo experiments, Gd-DTPA was administered to 6 glioblastoma patients before neurosurgery. The extracted bioptic tissue was then analyzed with spectromictroscopy, showing Gd localized in the nuclei of glioblastoma cells in 5 patients out of the 6 analyzed. (author)

  11. Hybrid core shell nanoparticles entrapping Gd-DTPA and18F-FDG for simultaneous PET/MRI acquisitions.

    Science.gov (United States)

    Vecchione, Donatella; Aiello, Marco; Cavaliere, Carlo; Nicolai, Emanuele; Netti, Paolo Antonio; Torino, Enza

    2017-09-01

    Although there has been an improvement in the hardware and software of the PET/MRI system, the development of the nanoprobes exploiting the simultaneous acquisition of the bimodal data is still under investigation. Moreover, few studies on biocompatible and clinically relevant probes are available. This work presents a core-shell polymeric nanocarrier with improved relaxometric properties for simultaneous PET/MRI acquisitions. Core-shell nanoparticles entrapping the Gd-DTPA and 18 F-FDG are obtained by a complex coacervation. The boosting of r 1 of the entrapped Gd-DTPA up to five-times compared with 'free Gd-DTPA', is confirmed by the PET/MRI scan. The sorption of 18 F-FDG into the nanoparticles is studied and designed to be integrated downstream for the production of the tracer.

  12. Effect of different levels of continuous positive airway pressure on the 99mTc-DTPA lung clearance

    Directory of Open Access Journals (Sweden)

    Dulciane Nunes Paiva

    2014-04-01

    Full Text Available Backgound and Objectives: Positive airway pressure continues (CPAP produces significant hemodynamic changes that may influence the variability of breathing pattern and heart rate, acting as an additional therapy to prevent atelectasis and to combat hypoxia. The rate of inhaled 99 m Technetiumdiethylenetriaminepentaacetic acid (99mTc-DTPA, along with changes in the lung epithelium cause an increase in the rate of clearance of this compound. The aim of this study was evaluate the pulmonary clearance rate of 99mTechnetium Diethylenetriaminepentaacetic acid (99mTc-DTPA through the use of different levels of CPAP. Methods: It was a quasi-experimental study involving 17 healthy individuals with normal lung functional. 99mTc-DTPA, as aerosol, was nebulized for 3 minutes with the individual in a sitting position. The pulmonary clearance rate was assessed through pulmonary scintigraphy under spontaneous breathing and under 20 and 10 cmH2 O CPAP in the sitting position. The clearance rate was expressed as the half-time (T½ that is the time for the activity to decrease to 50% of the peak value. Results: 20 cmH2 O CPAP produced significant reduction of the T½ of 99mTc-DTPA in the sitting position (p=0.005. However, 10 cmH2 O CPAP did not alter the T½ of DTPA in the same positions. Conclusion: High levels of continuos positive pressure in normal lungs resulted in faster 99mTc-DTPA clearance moreover, 10 cmH2 O did not alter its clearance rate. KEYWORDS: Noninvasive ventilation. Technetium Tc 99m Pentetate. Radionuclide Imaging.

  13. Preparation of 166 Dy/166 Ho DTPA-bis biotin as a system of In vivo generator

    International Nuclear Information System (INIS)

    Jimenez V, M.R.

    2003-01-01

    The objective of this work was to synthesize the complex 166 Dy/ 166 Ho - diethylen triamine pentaacetic-bis Biotin ( 166 Dy/ 166 Ho DTPA-bis Biotin) to evaluate its potential as a new radiopharmaceutical in directed radiotherapy. The Dysprosium-166 was obtained for neutron irradiation of 164 Dy 2 0 3 in the TRIGA Mark III reactor. The labelled was carried out in aqueous solution to p H 8.0 for addition of 166 Dy Cl 3 to the diethylen triamine pentaacetic-α, ω-bis Biotin (DTPA-bis Biotin). The radiochemical purity was determined for HPLC and ITLC. The biological integrity of the marked biotin is evaluated by the biological recognition of the avidin for HPLC - molecular exclusion with and without avidin addition. The studies of stability in vitro were made in dilutions of saline solution to 0.9% and with human serum at 37 C incubated 1 and 24 hours. The complex 166 Dy/ 166 Ho DTPA-bis Biotin was obtained with a radiochemical purity of 99.1 ± 0.6%. The biological recognition of the complex 166 Dy/ 166 Ho DTPA-bis Biotin for the avidin it doesn't affect the labelling procedure. The studies in vitro demonstrated that the 166 Dy/ 166 Ho DTPA-bis Biotin is stable after the dilution in saline solution and in human serum that there is not translocation of the one radionuclide subsequent son to the beta decay of the 166 Dy that could produce the 166 Ho 3+ liberation. The studies of Biodistribution in healthy mice demonstrated that the one complex 166 Dy/ 166 Ho DTPA-bis Biotin have a high renal distribution. In conclusion the radiolabelled biotin in this investigation has the appropriate properties to be used as an In vivo generator system stable for directed radiotherapy. (Author)

  14. A simple and inexpensive system for controlling body temperature in small animal experiments using MRI and the effect of body temperature on the hepatic kinetics of Gd-EOB-DTPA.

    Science.gov (United States)

    Murase, Kenya; Assanai, Purapan; Takata, Hiroshige; Saito, Shigeyoshi; Nishiura, Motoko

    2013-12-01

    The purpose of this study was to develop a simple and inexpensive system for controlling body temperature in small animal experiments using magnetic resonance imaging (MRI) and to investigate the effect of body temperature on the kinetic behavior of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) in the liver. In our temperature-control system, body temperature was controlled using a feedback-regulated heated or cooled air flow generated by two Futon dryers. The switches of the two Futon dryers were controlled using a digital temperature controller, in which the rectal temperature of a mouse measured by an optical fiber thermometer was used as the input. In experimental studies, male ICR mice aged 8weeks old were used and allocated into 5 groups (39-, 36-, 33-, 30-, and 27-degree groups, n=10), in which the body temperature was maintained at 39 °C, 36 °C, 33 °C, 30 °C, and 27 °C, respectively, using our system. The dynamic contrast-enhanced MRI (DCE-MRI) data were acquired with an MRI system for animal experiments equipped with a 1.5-Tesla permanent magnet, for approximately 43min, after the injection of Gd-EOB-DTPA into the tail vein. After correction of the image shift due to the temperature-dependent drift of the Larmor frequency using the gradient-based image registration method with robust estimation of displacement parameters, the kinetic behavior of Gd-EOB-DTPA was analyzed using an empirical mathematical model. With the use of this approach, the upper limit of the relative enhancement (A), the rates of contrast uptake (α) and washout (β), the parameter related to the slope of early uptake (q), the area under the curve (AUC), the maximum relative enhancement (REmax), the time to REmax (Tmax), and the elimination half-life of the contrast agent (T1/2) were calculated. The body temperature of mice could be controlled well by use of our system. Although there were no significant differences in α, AUC, and q among groups, there

  15. 99mTc-DTPA aerosol for same-day post-perfusion ventilation imaging: Results of a multicentre study

    International Nuclear Information System (INIS)

    Koehn, H.; Koenig, B.; Bachmayr, S.; Markt, B.; Eber, O.; Lind, P.; Galvan, G.; Rettenbacher, L.; Holm, C.; Ogris, E.

    1993-01-01

    A multicentre study was performed in an attempt to evaluate a submicronic technetium-99m diethylene triamine penta-acetic acid aerosol generated by a newly developed delivery system, the aerosol production equipment (APE nebulizer), for same-day post-perfusion ventilation imaging in patients with clinically suspected pulmonary embolism. Quantitative comparison between the DTPA aerosol and krypton gas demonstrated a close correlation with respect to regional pulmonary distribution of activity and peripheral lung penetration (n=14, r=0.94, P 99m Tc-labelled DTPA aerosol is well suited for fast same-day post-perfusion ventilation imaging in patients with clinical suspicion of pulmonary embolism. (orig.)

  16. Comparison of inulin, iothalamate, and /sup 99m/Tc-DTPA for measurement of glomerular filtration rate

    International Nuclear Information System (INIS)

    Barbour, G.L.; Crumb, C.K.; Boyd, C.M.; Reeves, R.D.; Rastogi, S.P.; Patterson, R.M.

    1976-01-01

    Clearances of inulin, 125 I-iothalamate, and /sup 99m/Tc-Sn-DTPA were measured simultaneously in five mongrel dogs exhibiting a wide range of glomerular filtration rates (GFR). Standard constant-infusion inulin clearance was compared to radionuclide clearances after subcutaneous injection of the emitters mixed with aqueous epinephrine. All three substances were found to have virtually identical clearances. The accuracy, accessibility, low cost, low radiation hazard, and short half-life of /sup 99m/Tc-Sn-DTPA make it an excellent substance for measuring GFR. The subcutaneous technique offers an accuracy comparable to the more difficult constant-infusion method

  17. Synthesis, characterization and biological behavior of some Schiff's and Mannich base derivatives of Lamotrigine

    Directory of Open Access Journals (Sweden)

    A.A. Kulkarni

    2017-02-01

    Full Text Available A series of various Schiff's and Mannich base derivatives (N1–2 & ND1–6 of Lamotrigine with isatin and substituted isatin were synthesized to get more potent anticonvulsant agents. The starting material for the synthesis of various new Schiff's and Mannich base derivatives was isatin (1H-indole- 2, 3-dione which in turn was prepared from substituted isonitrosoacetanilide using aniline. Lamotrigine reacts with isatin & substituted isatin gave Schiff's bases (N1–2 which on reaction with various secondary amines (dimethylamine, diethylamine, morpholine produced Mannich bases (ND1–6. The structures of newly synthesized compounds were characterized by using TLC, UV, FT-IR, 1HNMR and studied for their anticonvulsant activity. Anticonvulsant activity of all the derivatives was evaluated by MES method using phenobarbitone sodium & Lamotrigine as standard drugs and % reduction of time spent by animals in extension, flexion, clonus, and stupor phase were noted. Compounds ND-4 and ND-6 showed significant anticonvulsant activity when compared with that of standard drugs. The remaining all compounds show moderate activity. Biological activity data of the synthesized derivatives revealed that, the synthesized derivatives are good anticonvulsant agents as compared to Lamotrigine.

  18. Synthesis and characterisation of [90Y]-Bz-DTPA-oct: a yttrium-90-labelled octreotide analogue for radiotherapy of somatostatin receptor-positive tumours

    International Nuclear Information System (INIS)

    Smith-Jones, Peter M.; Stolz, Barbara; Albert, Rainer; Ruser, Gerd; Briner, Ulrich; Maecke, Helmut R.; Bruns, Christian

    1998-01-01

    An investigation into the in vitro behaviour of two yttrium-90-labelled somatostatin analogues was performed. Further in vivo characterisation was performed with the most promising agent. A new DTPA-octreotide analogue (Bz-DTPA-oct) was synthesised by coupling a bifunctional DTPA chelator to the N-terminal amine of the D-Phe 1 of Tyr 3 -octreotide. This new SRIF analogue and DTPA-octreotide (OctreoScan) were radiolabelled with 90 Y prior to serum stability being evaluated. Receptor binding assays were also performed on the two radioligands using rat cortex membranes. The [ 90 Y]-Bz-DTPA-oct was further evaluated in vivo using tumour-bearing rats. The first conjugate (DTPA-octreotide) bound with a high affinity to SRIF receptors and the 90 Y complex was relatively stable in human serum (t 1/2 3.8 d for 90 Y lost to serum proteins). The second conjugate (Bz-DTPA-oct) also exhibited a high binding affinity to SRIF receptors, but it demonstrated an even slower loss of 90 Y to serum proteins (t 1/2 12.1 d). The in vivo evaluation of the more stable [ 90 Y]-Bz-DTPA-oct showed a very rapid and high accumulation in somatostatin receptor-positive tumours, which after 1 h resulted in tumour/nontumour ratios of 3.8, 21, and 4.9 (for blood, muscle, and liver, respectively). These tumour/nontumour ratios increased, and were by 24 h postinjection 138, 285, and 6.1 (for blood, muscle, and liver). Yttrium-90-labelled Bz-DTPa-oct is rapidly and selectively accumulated in somatostatin receptor-positive tissue. Octadentate Bz-DTPA-oct could be ligand for 90 Y radiotherapy of somatostatin receptor-positive tumours and their metastases

  19. Regioselective synthesis of fraxinellone-based hydrazone derivatives as insecticidal agents.

    Science.gov (United States)

    Guo, Yong; Yan, Yuan-Yuan; Yang, Chun; Yu, Xiang; Zhi, Xiao-Yan; Xu, Hui

    2012-09-01

    In continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, twenty-three new fraxinellone-based hydrazone derivatives were smoothly prepared from fraxinellone via regioselectively allylic oxidation in the presence of selenium dioxide or chromium trioxide under microwave irradiation and subsequent condensation with hydrazides or hydrazines. Their insecticidal activity was evaluated against the pre-third-instar larvae of Mythimna separata Walker in vivo. Especially compounds 6d and 7a displayed the most pronounced insecticidal activity compared with toosendanin, a commercial botanical insecticide derived from Melia azedarach. Copyright © 2012 Elsevier Ltd. All rights reserved.

  20. Quantitative evaluation of relative separate renal perfusion and function with Tc-99m-DTPA

    International Nuclear Information System (INIS)

    Seto, Hikaru; Kakishita, Masao; Futatsuya, Ryusuke; Tonami, Norihisa; Hisada, Kinichi.

    1980-01-01

    A new method of quantitative measurement of relative separate renal perfusion and function, using Tc-99m-DTPA and a scintillation camera interfaced to a computer was evaluated in various unilateral renal diseases. 1) Relative separate renal perfusion and function ratios with Tc-99m-DTPA were correlated well with I-131-Hippuran (r = 0.974). 2) Normal values in the subjects with healthy kidneys (n = 42) were as follows; Left kidney: 52.22 +- 2.5%, Right kidney: 47.8 +- 2.5%. No significant difference was noted between sexes. 3) Relative separate renal perfusion and function ratios and count densities of the diseased kidneys in unilateral obstructive uropathy (n = 28) and renal artery stenosis (n = 5) were significantly decreased (p < 0.001) in comparison with normal kidneys. Renal sizes of the diseased kidneys in renal artery stenosis were also significantly decreased (p < 0.001). However, no significant decrease was noted in unilateral obstructive uropathy. This method is simple, atraumatic and of great clinical value to detect unilateral renal disease and to evaluate or follow-up the functioning state of the diseased kidney. (author)

  1. Re-estimation of renal function with 99mTc-DTPA by the Gates' method

    International Nuclear Information System (INIS)

    Itoh, Kazuo; Arakawa, Masanori

    1987-01-01

    We analyzed a regression equation between percent total renal uptake (%TRU) of 99m Tc-DTPA and creatinine clearance (Ccr) by the Gates' method in 82 patients. 1) The following regression equations between measured renal depth on CT scan and (weight in kg)/(height in cm) in Japanese were obtained; Right in both kidneys = 13.6361 · (W/H) 0.6996 (n = 217, r = 0.86691, p 0.7554 (n = 224, r = 0.8822, p 0.8099 (n = 27, r = 0.9515, p 0.6997 (n = 21, r = 0.9213, p 2 ) = 13.15 · %TRU 0.787 (n = 86, r = 0.820, p 0.753 (n = 40, r = 0.754). The Gates' method is very convenient for an immediate estimation of glomerular filtration rate (GFR) after renal scintigraphy using 99m Tc-DTPA. However, the correlation coefficient was not high as compared to the Gates' results. The equation which was reported by Gates' is not necessarily adaptable in routine study. Each facility which uses the Gates' method for estimating GFR should obtain the corrected regression equation between %TRU and Ccr. (author)

  2. The detection of the dynamic renal function using MRI by gadolinium-DTPA

    International Nuclear Information System (INIS)

    Torii, Shinichiro; Machida, Toyohei; Ohoishi, Yukihiko; Tateno, Yukio; Fukuda, Nobuo.

    1988-01-01

    The mathematical study of dynamic renal function and the simulation of renal disorder in rabbit kidney using MRI by Gd-DTPA were performed. T1 of rabbit kidney, which had been operated (complete unilateral ureteral occlusion or incomplete unilateral occlusion of renal artery) was calculated before and after intravenous injection of 0.05 mmol/kg Gd-DTPA, continuously for 90 minutes. All images were obtained by the 0.1 Tesla resistive type MRI. The changes of 1/T1 of cortex and medulla of both kidneys were calculated (MRI renogram). The 4 compartment model of bilateral kidneys was established by 6 normal MRI renogram and renal blood flow-glommelurar function parameter and tubural excration function parameter were calculated by the Runge-Kutta-Gill method and the nonlinear least squares method (Simplex method). The change of renogram pattern was observed by the mathematical change of such parameters and comparative study was performed between such mathematical simulation and practical cases. The actual change of such parameters were calculated by the experimental model of rabbit kidney. It was concluded that the change of MRI renogram pattern was sensitive for unilateral hydronephrosis, renal parenchymal dysfunction by obstructive uropathy and unilateral renal arterial stenosis. Quantitative observation of focal renal parenchymal dysfunction, which was induced by ureteral obstruction, was possible. In the near future it will be also possible to detect acculate ERBF and GFR by the measurement of T1 of human kidney. (author)

  3. Utility of Gd-EOB-DTPA-Enhanced MRI in Diagnosing Small Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    Soo Ryang Kim

    2009-07-01

    Full Text Available We describe an 8-mm hepatocellular carcinoma (HCC with hepatitis C virus-related cirrhosis in a 74-year-old woman. Ultrasound (US revealed an 8-mm hyperechoic nodule in segment 6 of the liver. Contrast-enhanced computed tomography (CT and US revealed no hypervascularity in the early phase and no washout in the late phase and the Kupffer phase, respectively. CT during arteriography revealed no hypervascularity and CT during arterial portography disclosed no perfusion defect. Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI revealed no hypervascularity in the early phase, but disclosed a defect in the hepatobiliary phase. Histologically, the nodule was diagnosed as well-differentiated HCC characterized by more than two-fold the cellularity of the non-tumorous area, with a high nuclear:cytoplasmic ratio, increased cytoplasmic eosinophilia, fatty change, and slight cell atypia with an irregular thin trabecular pattern. Our case demonstrates the utility of Gd-EOB-DTPA-enhanced MRI in the diagnosis of small HCC.

  4. Effects of sustained exercise on pulmonary clearance of aerosolized 99mTc-DTPA

    International Nuclear Information System (INIS)

    Lorino, A.M.; Meignan, M.; Bouissou, P.; Atlan, G.

    1989-01-01

    The effects of intensive prolonged exercise on the pulmonary clearance rate of aerosolized 99m Tc-labeled diethylenetriaminepentaacetate ( 99m Tc-DTPA) and pulmonary mechanics were studied in seven healthy nonsmoking volunteers. 99m Tc-DTPA clearance and pulmonary mechanics (lung volumes and compliance) were assessed before and after 75 min of constant-load exercise performed on a treadmill, corresponding to 75% of maximal O 2 uptake. Because both clearance measurements were made in similar conditions of pulmonary blood flow, respiratory rate, and tidal volume, changes in clearance rate can be assumed to represent changes of alveolar epithelial permeability. After exercise, total, apical, and basal clearance were significantly increased (P less than 0.01, 0.05, and 0.05, respectively) and the increases in total clearance and tidal volume observed during exercise were significantly correlated (P less than 0.05). In contrast, no significant change was found in pulmonary mechanics. These results show that prolonged intensive exercise induces an increase in epithelial permeability, which appears to be related to the mechanical effects of sustained increased ventilation. Because no change was evidenced in pulmonary volumes or in lung elasticity, our results suggest that this increase may result from alteration of the intercellular tight junctions rather than from a surfactant deficiency

  5. Late aftereffect of inhailed 239Pu labelled with Ca or ZnDTPA

    International Nuclear Information System (INIS)

    Levdik, T.I.; Lyubchanskij, Eh.R.; Nifatov, A.P.

    1979-01-01

    Experiments made on rats showed that early (in 30 min and 3 h) aerosol therapy with Ca- or ZnDTPA and subsequent (during 2 months) intraperitoneal administration of respective DTPA salts after inhalation of 0.08-0.06 μCi of 239 Pu nitrate (pH 1.0) give ground to reduce the dose in the lungs from 915-690 down to 440-348 rad, in the skeleton from 74-64 down to 7.0-5.4 rad and also to provide the prolongation of the life span of rats from 522-602 up to 667-658 days. The incidence of inflammatory processes and malignant new growths undergoes no changes under the effect of complexonotherapy but the time of their development draws back, and the spectrum of tumours varies. In the treated rats the incidence of hemangiosarcomas of the lungs and osteosarcomas decreases and that of reticulosarcomas of the lungs increases. The life span of these animals is reduced by 100-150 days against the average in animals (16.6-26.2%) with severe inflammatory processes. The expediency of using antiinflammatory agents and the drugs raising the resistance of the body is discussed

  6. Gadolinium-DTPA enhancement of symptomatic nerve roots in MRI of the lumbar spine

    Energy Technology Data Exchange (ETDEWEB)

    Tyrrell, P.N.M.; Cassar-Pullicino, V.N.; McCall, I.W. [Department of Diagnostic Imaging, The Institute of Orthopaedics, The Robert Jones and Agnes Hunt Orthopaedic and District Hospital NHS Trust, Oswestry, Shropshire SY10 7AG (United Kingdom)

    1998-02-01

    Disc prolapse presenting with sciatica may be associated with enhancement of the symptomatic nerve root following magnetic resonance imaging (MRI) with intravenous gadolinium (Gd)-DTPA. Previous studies have shown, however, that this does not occur in all cases. The aim of this study was to assess the incidence of nerve root enhancement in patients with sciatica and disc prolapse and to try to identify any specific features that might be associated with the phenomenon. A total of 227 patients presenting with low back pain and/or sciatica underwent a MRI study of the lumbar spine with intravenous contrast enhancement. Nineteen of 81 (23.5 %) patients with disc prolapse demonstrated nerve root enhancement. Nerve root enhancement had a highly significant association with sequestrated disc lesions (13/19, 68 %; P < 0.0005), and was primarily seen in the symptomatic ipsilateral nerve root (16/19, 84 %). The sensitivity of nerve root enhancement associated with disc prolapse was 23.5 % with a specificity of 95.9 %, a positive predictive value of 76 % and a negative predictive value of 69.3 %. Nerve root enhancement may be indicative of the symptomatic level but its poor sensitivity negates the routine use of Gd-DTPA in MRI for sciatica. (orig.) With 4 figs., 1 tab., 37 refs.

  7. Signal effects of various radiographic contrast media and their interaction with gadolinium DTPA during MRT

    International Nuclear Information System (INIS)

    Kopka, L.; Funke, M.; Fischer, U.; Vosshenrich, R.; Schroeder, M.; Grabbe, E.

    1994-01-01

    T 1 and T 2 weighted signals dereived from various radiological contrast media were studied during MRT spin-echo sequences. In addition, the interaction between radiological contrast media and Gadolinium-DTPA concerning T 1 signals was evaluated. Ionic (ioxitalaminic acid) and non-ionic radiological contrast media (Iopromid, Iotrolan) were used in diagnostic concentrations. Measurements were carried out with a superconductive magnet of 1.5 Tesla. Radiological contrast media produced significantly higher signals than a physiological sodium chloride solution in T 1 -weighted spin-echo sequences. Evn small amounts (15% of total volume) of radiological contrast media during T 1 -weighted spin-echo sequences led to a significant reduction (about 25%) of the signal intensity of a 2 mM Gadolinium-DTPA solution. This may lead to diagnostic problems, as was shown in a series of 25 MR arthrograms of the shoulder. It is recommended than an interval of at least 6 hours should elapse between the use of a radiological contrst medium and an MRT examination. (orig.) [de

  8. Vacina difteria, tétano e pertussis acelular (dTpa na gravidez: prevenção da tosse convulsa no lactente

    Directory of Open Access Journals (Sweden)

    Vera Amaral

    2015-09-01

    Full Text Available Introdução: Atualmente observa-se uma reemergência de tosse convulsa em países com elevadas coberturas vacinais, incluindo Portugal. Os lactentes com menos de três meses de idade constituem o grupo mais vulnerável. Novas estratégias vacinais têm sido propostas, entre as quais a vacinação no terceiro trimestre de gravidez. No entanto, a sua implementação é ainda limitada, existindo dúvidas quanto à sua eficácia e segurança. Objectivo: Rever a evidência quanto à eficácia e segurança da vacina difteria, tétano e pertussis acelular (dTpa administrada na gravidez na prevenção da tosse convulsa no lactente. Métodos: Foram pesquisadas normas de orientação clínica (NOC, revisões sistemáticas e estudos originais (EO na Medline, bases de dados de medicina baseada na evidência e sítios da Direção-Geral da Saúde e Sociedade Portuguesa de Pediatria. Utilizaram-se os termos MeSH pertussis vaccine e pregnancy e foram selecionados artigos publicados entre 01/07/09 e 15/07/2014 nas línguas portuguesa, inglesa e espanhola. Desenvolvimento: A maioria das NOC recomenda a vacinação de todas as grávidas no terceiro trimestre. Os EO mostram que a dTpa administrada na gravidez é eficaz no aumento da concentração de anticorpos anti-pertussis maternos e do lactente e na diminuição dos casos de doença e de hospitalizações em lactentes. A vacina não parece associar-se a aumento de efeitos adversos materno-fetais ou nas crianças. Conclusões: A vacinação com dTpa durante o terceiro trimestre de gravidez parece ser segura e eficaz na prevenção da tosse convulsa no lactente.

  9. Analytical derivation: An epistemic game for solving mathematically based physics problems

    Science.gov (United States)

    Bajracharya, Rabindra R.; Thompson, John R.

    2016-06-01

    Problem solving, which often involves multiple steps, is an integral part of physics learning and teaching. Using the perspective of the epistemic game, we documented a specific game that is commonly pursued by students while solving mathematically based physics problems: the analytical derivation game. This game involves deriving an equation through symbolic manipulations and routine mathematical operations, usually without any physical interpretation of the processes. This game often creates cognitive obstacles in students, preventing them from using alternative resources or better approaches during problem solving. We conducted hour-long, semi-structured, individual interviews with fourteen introductory physics students. Students were asked to solve four "pseudophysics" problems containing algebraic and graphical representations. The problems required the application of the fundamental theorem of calculus (FTC), which is one of the most frequently used mathematical concepts in physics problem solving. We show that the analytical derivation game is necessary, but not sufficient, to solve mathematically based physics problems, specifically those involving graphical representations.

  10. Design of Chitosan and Its Water Soluble Derivatives-Based Drug Carriers with Polyelectrolyte Complexes

    Directory of Open Access Journals (Sweden)

    Qing-Xi Wu

    2014-12-01

    Full Text Available Chitosan, the cationic polysaccharide derived from the natural polysaccharide chitin, has been studied as a biomaterial for more than two decades. As a polycationic polymer with favorable properties, it has been widely used to form polyelectrolyte complexes with polyanions for various applications in drug delivery fields. In recent years, a growing number of studies have been focused on the preparation of polyelectrolyte complexes based on chitosan and its water soluble derivatives. They have been considered well-suited as biomaterials for a number of vital drug carriers with targeted/controlled release profiles, e.g., films, capsules, microcapsules. In this work, an overview highlights not only the favorable properties of chitosan and its water soluble derivatives but also the good performance of the polyelectrolyte complexes produced based on chitosan. Their various types of applications as drug carriers are reviewed in detail.

  11. Design of Chitosan and Its Water Soluble Derivatives-Based Drug Carriers with Polyelectrolyte Complexes

    Science.gov (United States)

    Wu, Qing-Xi; Lin, Dong-Qiang; Yao, Shan-Jing

    2014-01-01

    Chitosan, the cationic polysaccharide derived from the natural polysaccharide chitin, has been studied as a biomaterial for more than two decades. As a polycationic polymer with favorable properties, it has been widely used to form polyelectrolyte complexes with polyanions for various applications in drug delivery fields. In recent years, a growing number of studies have been focused on the preparation of polyelectrolyte complexes based on chitosan and its water soluble derivatives. They have been considered well-suited as biomaterials for a number of vital drug carriers with targeted/controlled release profiles, e.g., films, capsules, microcapsules. In this work, an overview highlights not only the favorable properties of chitosan and its water soluble derivatives but also the good performance of the polyelectrolyte complexes produced based on chitosan. Their various types of applications as drug carriers are reviewed in detail. PMID:25532565

  12. Synthesis and evaluation of a class of 1,4,7-triazacyclononane derivatives as iron depletion antitumor agents.

    Science.gov (United States)

    Wang, Sheng; Gai, Yongkang; Zhang, Shasha; Ke, Lei; Ma, Xiang; Xiang, Guangya

    2018-01-15

    Iron depletion has been confirmed as an efficient strategy for cancer treatment. In the current study, a series of 1,4,7-triazacyclononane derivatives HE-NO2A, HP-NO2A and NE2P2A, as well as the bifunctional chelators p-NO 2 -PhPr-NE3TA and p-NH 2 -PhPr-NE3TA were synthesized and evaluated as iron-depleting agents for the potential anti-cancer therapy against human hepatocellular carcinoma. The cytotoxicity of these chelators was measured using hepatocellular cancer cells and compared with the clinically available iron depletion agent DFO and the universal metal chelator DTPA. All these 1,4,7-triazacyclononane-based chelators exhibited much stronger antiproliferative activity than DFO and DTPA. Among them, chelators with phenylpropyl side chains, represented by p-NO 2 -PhPr-NE3TA and p-NH 2 -PhPr-NE3TA, displayed the highest antiproliferative activity against HepG2 cells. Hence, these compounds are attractive candidates for the advanced study as iron depletion agents for the potential anti-cancer therapy, and could be further in conjugation with a targeting moiety for the future development in targeted iron depletion therapy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. C60-based ebselen derivative: synthesis by bingel cyclopropanation and enhanced antioxidative and neuroprotective activity

    International Nuclear Information System (INIS)

    Xufeng Liu; Wenchao Guan; Wengshan Ke

    2007-01-01

    C 60 -based ebselen derivative 3 was synthesized through Bingel cyclopropanation of C 60 with the ebselen malonate 2. Compound 3 was obtained in 42% yield (based on consumed C 60 ) in a three-step synthesis starting from 2-(chloroseleno)benzoyl chloride and 2-(2aminoethoxy)ethanol. Its structure was confirmed by 1H NMR, 13 C NMR, IR, UV and FAB-MS spectroscopy analyses. In order to verify the enhanced antioxidative and neuroprotective activity of 3, a C 60 derivative (4), an ebselen derivative (2), and their mixture (4 plus 2 in equimolar ratio) were employed to treat cortical neuronal cells, following the same procedure used with 3 and at the same final concentration (30 μmol L -1 ). Cell viabilities of the four treated groups were estimated by LDH (lactic dehydrogenase) leakage and MTT (3-(4, 5-dimethylthiazole-2yl)-2,5-diphenyl-tetrazolium bromide) assays. Results showed that the antioxidative and protective activities of C 60 -based ebselen derivative 3 against H 2 O 2 -mediated neuronal injury (MTT(OD) 0.364 ± 0.028; LDH release (UL -1 ) 4.66 ± 0.28) were significantly higher than those of C 6 )0 derivative 4 (MTT(OD) 0.324 ± 0.025; LDH release (UL -1 ) 5.39 ± 0.17), ebselen derivative 2 (MTT(OD) 0.294 ± 0.021; LDH release (UL -1 ) 5.71 ± 0.27), and the mixture of 4 and 2 (MTT(OD) 0.310 ± 0.018; LDH release (UL -1 ) 5.54 ±0.39). These findings demonstrated that the combination of two molecular units with similar biological activities (C 60 and ebselen) may be a desirable way of obtaining new and more biologically effective C 60 -based compounds. (author)

  14. Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy.

    Science.gov (United States)

    Kudou, Naoki; Taniguchi, Akira; Sugimoto, Kenji; Matsuya, Yuji; Kawasaki, Masashi; Toyooka, Naoki; Miyoshi, Chika; Awale, Suresh; Dibwe, Dya Fita; Esumi, Hiroyasu; Kadota, Shigetoshi; Tezuka, Yasuhiro

    2013-02-01

    A series of new (-)-arctigenin derivatives with variably modified O-alkyl groups were synthesized and their preferential cytotoxicity was evaluated against human pancreatic cancer cell line PANC-1 under nutrient-deprived conditions. The results showed that monoethoxy derivative 4i (PC(50), 0.49 μM), diethoxy derivative 4h (PC(50), 0.66 μM), and triethoxy derivative 4m (PC(50), 0.78 μM) showed the preferential cytotoxicities under nutrient-deprived conditions, which were identical to or more potent than (-)-arctigenin (1) (PC(50), 0.80 μM). Among them, we selected the triethoxy derivative 4m and examined its in vivo antitumor activity using a mouse xenograft model. Triethoxy derivative 4m exhibited also in vivo antitumor activity with the potency identical to or slightly more than (-)-arctigenin (1). These results would suggest that a modification of (-)-arctigenin structure could lead to a new drug based on the antiausterity strategy. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  15. CONFAC Decomposition Approach to Blind Identification of Underdetermined Mixtures Based on Generating Function Derivatives

    NARCIS (Netherlands)

    de Almeida, Andre L. F.; Luciani, Xavier; Stegeman, Alwin; Comon, Pierre

    2012-01-01

    This work proposes a new tensor-based approach to solve the problem of blind identification of underdetermined mixtures of complex-valued sources exploiting the cumulant generating function (CGF) of the observations. We show that a collection of second-order derivatives of the CGF of the

  16. Single-Phase Phase-Locked Loop Based on Derivative Elements

    DEFF Research Database (Denmark)

    Guan, Qingxin; Zhang, Yu; Kang, Yong

    2017-01-01

    High-performance phase-locked loops (PLLs) are critical for power control in grid-connected systems. This paper presents a new method of designing a PLL for single-phase systems based on derivative elements (DEs). The quadrature signal generator (QSG) is constructed by two DEs with the same...

  17. Sensing of polymeric sensor-based rhodamine B derivative for metal ...

    Indian Academy of Sciences (India)

    ity after complexes with metal ions by activating a carbonyl group in a spirolactone or a spirolactam moiety [27–30]. The mechanism is based on the switch off/on of the spirocyclic moiety mediated by guests. In general, spirolactam formation of rhodamine derivatives is non-fluorescent, whereas its ring-opened amide system ...

  18. An approach for deriving growth equations for quantities exhibiting cumulative growth based on stochastic interpretation

    Science.gov (United States)

    Moriguchi, Kai

    2018-01-01

    Existing growth equations have been derived by hypothesizing the growth rate as self-referencing. Although that hypothesis is appropriate for quantities with growth directly restricted to themselves, it requires the solution of differential equations that are difficult to be derived. However, for quantities of growth that are indirectly related to themselves, and for quantities that exhibit cumulative growth, such as growth of diameter or volume of trees with lignification, ordinary growth models with assumptions that include self-referencing or implied catabolism terms might not be appropriate. For such quantities, the author proposes an approach for derivation of growth models based on stochastic and microscopic interpretation. Results show that ordinary growth models can be interpreted from the perspective. The approach enables one to derive growth functions without solving differential equations. Based on that approach, growth functions are derived by integrating cumulative distribution functions. Three growth functions are generated using reasonable probability distributions. The fitness of the generated growth functions for real diameter growth data was compared with that of generalized ordinary growth models. Results show that the presented approach has high ability to generate growth models that fit data much better than ordinary growth models for a given number of parameters.

  19. Computing derivative-based global sensitivity measures using polynomial chaos expansions

    International Nuclear Information System (INIS)

    Sudret, B.; Mai, C.V.

    2015-01-01

    In the field of computer experiments sensitivity analysis aims at quantifying the relative importance of each input parameter (or combinations thereof) of a computational model with respect to the model output uncertainty. Variance decomposition methods leading to the well-known Sobol' indices are recognized as accurate techniques, at a rather high computational cost though. The use of polynomial chaos expansions (PCE) to compute Sobol' indices has allowed to alleviate the computational burden though. However, when dealing with large dimensional input vectors, it is good practice to first use screening methods in order to discard unimportant variables. The derivative-based global sensitivity measures (DGSMs) have been developed recently in this respect. In this paper we show how polynomial chaos expansions may be used to compute analytically DGSMs as a mere post-processing. This requires the analytical derivation of derivatives of the orthonormal polynomials which enter PC expansions. Closed-form expressions for Hermite, Legendre and Laguerre polynomial expansions are given. The efficiency of the approach is illustrated on two well-known benchmark problems in sensitivity analysis. - Highlights: • Derivative-based global sensitivity measures (DGSM) have been developed for screening purpose. • Polynomial chaos expansions (PC) are used as a surrogate model of the original computational model. • From a PC expansion the DGSM can be computed analytically. • The paper provides the derivatives of Hermite, Legendre and Laguerre polynomials for this purpose

  20. Utility of radioisotopic filtration markers in chronic renal insufficiency: Simultaneous comparison of 125I-iothalamate, 169Yb-DTPA, 99mTc-DTPA, and inulin. The Modification of Diet in Renal Disease Study

    International Nuclear Information System (INIS)

    Perrone, R.D.; Steinman, T.I.; Beck, G.J.; Skibinski, C.I.; Royal, H.D.; Lawlor, M.; Hunsicker, L.G.

    1990-01-01

    Assessment of glomerular filtration rate (GFR) with inulin is cumbersome and time-consuming. Radioisotopic filtration markers have been studied as filtration markers because they can be used without continuous intravenous (IV) infusion and because analysis is relatively simple. Although the clearances of 99mTc-DTPA, 169Yb-DTPA, and 125I-iothalamate have each been compared with inulin, rarely has the comparability of radioisotopic filtration markers been directly evaluated in the same subject. To this purpose, we determined the renal clearance of inulin administered by continuous infusion and the above radioisotopic filtration markers administered as bolus injections, simultaneously in four subjects with normal renal function and 16 subjects with renal insufficiency. Subjects were studied twice in order to assess within-study and between-study variability. Unlabeled iothalamate was infused during the second half of each study to assess its effect on clearances. We found that renal clearance of 125I-iothalamate and 169Yb-DTPA significantly exceeded clearance of inulin in patients with renal insufficiency, but only by several mL.min-1.1.73m-2. Overestimation of inulin clearance by radioisotopic filtration markers was found in all normal subjects. No differences between markers were found in the coefficient of variation of clearances either between periods on a given study day (within-day variability) or between the two study days (between-day variability). The true test variability between days did not correlate with within-test variability. We conclude that the renal clearance of 99mTc-DTPA, 169Yb-DTPA, or 125I-iothalamate administered as a single IV or subcutaneous injection can be used to accurately measure GFR in subjects with renal insufficiency; use of the single injection technique may overestimate GFR in normal subjects

  1. Capillary permeability of 99mTc-DTPA in canine myocardium determined by intracoronary bolus injection and residue detection

    DEFF Research Database (Denmark)

    Svendsen, J H; Efsen, Fritz; Haunsø, S

    1989-01-01

    Capillary permeability of 99mtechnetium-diethylenetriaminepenta-acetic acid (99mTc-DTPA; MW 485.0) and 51chromium-ethylenediaminetetra-acetate (51Cr-EDTA; MW 340.2) was studied in an in vivo canine heart preparation by the single injection, residue detection (SIRD) method. In experiments on open...

  2. Stability, protein binding and clearance studies of [99mTc]DTPA. Evaluation of a commercially available dry-kit

    DEFF Research Database (Denmark)

    Rehling, M

    1988-01-01

    the quality of a commercial [99mTc]DTPA preparation (C.I.S., France) with reference to stability, protein binding and accuracy of the determined plasma clearance values as a measure of GFR. The stability of the preparations was studied by thin-layer chromatography, the in vitro protein binding by Sephadex...

  3. Magnetic resonance tomography for focal lesions in the liver using the para-magnetic contrast medium gadolinium DTPA

    International Nuclear Information System (INIS)

    Hamm, B.; Roemer, T.; Felix, R.; Wolf, K.J.; Klinikum Charlottenburg, Berlin

    1986-01-01

    The use of the para-magnetic contrast medium gadolinium DTPA for magnetic resonance tomography of focal lesions in the liver was investigated in 31 patients. Two dosage schedules of the contrast medium (0.1 and 0.2 mmol/kg body weight) were used with field strengths of 0.35 and 0.5 Tesla. Using T 1 sequences, gadolinium DTPA showed increased signal intensity in the liver and in tumours, but this was significantly more marked in the tumour. On T 1 spin-echo sequences, previously iso-intense lesions became visible after administration of contrast. On the other hand, contrast-enhanced lesions were less well seen on inversion recovery sequences because of a reduction in the contrast between tumour and liver tissue. The contrast between tumour and liver tissue was not improved by gadolinium DTPA in comparison with precontrast inversion recovery sequences and T 2 spin-echo sequences. The perfusion of intra-hepatic tumours could be elucidated by magnetic resonance tomography after the administration of gadolinium DTPA. (orig.) [de

  4. [111In-DTPA-D-Phe1] octreotide scintigraphy in thyroidal and orbital Graves' disease: a parameter for disease activity?

    NARCIS (Netherlands)

    Postema, P. T.; Krenning, E. P.; Wijngaarde, R.; Kooy, P. P.; Oei, H. Y.; van den Bosch, W. A.; Reubi, J. C.; Wiersinga, W. M.; Hooijkaas, H.; van der Loos, T.

    1994-01-01

    Visualization of malignant lymphomas and granulomatous disease is possible by [111In-DTPA-D-Phe1]octreotide scintigraphy through binding of the radioligand to somatostatin receptors on activated leukocytes. Because thyroidal and orbital tissues are infiltrated by activated leukocytes in Graves'

  5. Glomerular filtration rate in relation to extracellular fluid volume: similarity between 99mTc-DTPA and inulin

    International Nuclear Information System (INIS)

    Gunasekera, R.D.; Allison, D.J.; Peters, A.M.

    1996-01-01

    The aim of the present study was to compare 99m Tc-DTPA plasma clearance kinetics with those of inulin, injected simultaneously, with respect especially to α 2 , rapidity of equilibration within the distribution volume and the components and size of the distribution volume. (orig./MG)

  6. 99mTc-DTPA renal scanning as a confirmatory study in the diagnosis of neonatal adrenal hemorrhage

    International Nuclear Information System (INIS)

    Habif, D.V. Jr.; Berdon, W.E.; Baker, D.H.; Pritzker, H.; Fawwaz, R.; Johnson, P.

    1979-01-01

    99mTc-DTPA renal scanning offers a method for demonstrating adrenal hemorrhage as a cause of flank mass in the neonate and for assessing renal function. The hemorrhagic adrenal appears as a tracer-free area over the flattened and displaced kidney. The method is low in radiation and is not hampered by obscuring bowel contents

  7. 177Lu-DTPA-BIS-BIOTIN Binding of Octreotide-dextran-avidinated PANC-1 Cell Lines in Vitro

    International Nuclear Information System (INIS)

    Deng Xinrong; Zhai Shizhen; Shen Yijia; Luo Zhifu; Du Jin

    2011-01-01

    Tyr3-octreotide, dextran-40 and avidin were used to prepare octreotide-dextran-avidin (TOC-Dx 40 -Av). DTPA-BIS-BIOTIN was labelled with 177 Lu. The in vitro somatostatin receptor binding study was carried out by pretargeted method using TOC-Dx 40 -Av and 177 Lu-DTPA-BIS-BIOTIN. The 24 well cell culture plates were prepared with PANC-1 cell monolayer and then incubated with TOC-Dx 40 -Av. After two washed with PBS, the cells were incubated with different concentration of 177 Lu-DTPA-BIS-BIOTIN (48.8 ∼ 391 pmol). Cells uptake was evaluated with γ counter. The results showed that the chemical purity of TOC-Dx 40 -Av was over 99%. The results also showed that TOC-Dx 40 -Av remained high receptor binding affinity to somatostatin receptor which indicated that TOC- Dx 40 -Av could bind to 177 Lu-DTPA-BIS-BIOTIN with the molar ratio of 1 : 1 on the cell surface. (authors)

  8. Preparation of 177Lu-DOTA/DTPA-Bz-Cys-RGD dimer and biodistribution evaluation in normal mice

    International Nuclear Information System (INIS)

    Sheng Feng; Jia Bing; Wang Fan; He Weiwei; Liu Zhaofei; Zhao Huiyun

    2008-01-01

    177 Lu-DOTA-Bz-Cys-RGD dimer and 177 Lu-DTPA-Bz-Cys-RGD dimer were prepared, and the in vitro and in vivo properties were compared. TLC and HPLC show that the labeling yields of two radiolabeled compounds are more than 95% under optimal conditions (pH=5.0, reacting at 100 degree C for 15-20 min), and the two radiolabeled compounds show pretty good in vitro stability. HPLC analyses and lg P values reveal that lipophilicity of 177 Lu-DOTA-Bz-Cys- RGD dimer is higher than 177 Lu-DTPA-Bz-Cys-RGD dimer. The uptake of 177 Lu-DTPA-Bz-Cys- RGD dimer in other tissues is significantly higher than that of 177 Lu-DOTA-Bz-Cys-RGD dimer at 4 h postinjection, except for blood and spleen. The in vivo stability of 177 Lu-DOTA-Bz-Cys-RGD dimer is much better than 177 Lu-DTPA-Bz-Cys-RGD dimer. Bz-DOTA is an ideal bifunctional chelator for 177 Lu labeling of RGD dimer. (authors)

  9. Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives

    Directory of Open Access Journals (Sweden)

    Denisa Leonte

    2015-07-01

    Full Text Available This paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings (thiazole, furane, thiophene, pyridine by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild and eco-friendly reaction conditions. The obtained Mannich bases were acylated to their corresponding N-acetyl derivatives. All compounds were characterized by 1H-NMR, 13C-NMR and MS spectrometry.

  10. Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives.

    Science.gov (United States)

    Leonte, Denisa; Bencze, László Csaba; Paizs, Csaba; Irimie, Florin Dan; Zaharia, Valentin

    2015-07-06

    This paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings (thiazole, furane, thiophene, pyridine) by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild and eco-friendly reaction conditions. The obtained Mannich bases were acylated to their corresponding N-acetyl derivatives. All compounds were characterized by 1H-NMR, 13C-NMR and MS spectrometry.

  11. A derivative-free approach for a simulation-based optimization problem in healthcare

    OpenAIRE

    Lucidi, Stefano; Maurici, Massimo; Paulon, Luca; Rinaldi, Francesco; Roma, Massimo

    2016-01-01

    In this work a simulation-based optimization model is considered in the framework of the management of hospital services. Given specific parameters which describe the hospital setting, the simulation model aims at reproducing the hospital processes and evaluating their efficiency. The use of a simulation-based optimization approach is necessary since the model can not be expressed as closed–form function. In order to obtain the optimal setting, we combine a derivative-free optimization meth...

  12. Separation of piracetam derivatives on polysaccharide-based chiral stationary phases.

    Science.gov (United States)

    Kažoka, H; Koliškina, O; Veinberg, G; Vorona, M

    2013-03-15

    High-performance liquid chromatography was used for the enantiomeric separation of two chiral piracetam derivatives. The suitability of six commercially available polysaccharide-based chiral stationary phases (CSPs) under normal phase mode for direct enantioseparation has been investigated. The influence of the CSPs as well the nature and content of an alcoholic modifier in the mobile phase on separation and elution order was studied. It was established that CSP Lux Amylose-2 shows high chiral recognition ability towards 4-phenylsubstituted piracetam derivatives. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. Gd-EOB-DTPA-enhanced MR guidance in thermal ablation of liver malignancies.

    Directory of Open Access Journals (Sweden)

    Christian Rosenberg

    Full Text Available OBJECTIVE: To evaluate the potency of Gd-EOB-DTPA to support hepatic catheter placement in laser ablation procedures by quantifying time-dependent delineation effects for instrumentation and target tumor within liver parenchyma. Monitoring potential influence on online MR thermometry during the ablation procedure is a secondary aim. MATERIALS AND METHODS: 30 cases of MR-guided laser ablation were performed after i.v. bolus injection of gadoxetic acid (0.025 mmol/Kg Gd-EOB-DTPA; Bayer Healthcare, Berlin, Germany. T1-weighted GRE sequences were used for applicator guidance (FLASH 3D in the catheter placement phase and for therapy monitoring (FLASH 2D in the therapy phase. SNR and consecutive CNR values were measured for elements of interest plotted over time both for catheter placement and therapy phase and compared with a non-contrast control group of 19 earlier cases. Statistical analysis was realized using the paired Wilcoxon test. RESULTS: Sustainable signal elevation of liver parenchyma in the contrast-enhanced group was sufficient to silhouette both target tumor and applicator against the liver. Differences in time dependent CNR alteration were highly significant between contrast-enhanced and non-contrast interventions for parenchyma and target on the one hand (p = 0.020 and parenchyma and instrument on the other hand (p = 0.002. Effects lasted for the whole procedure (monitoring up to 60 min and were specific for the contrast-enhanced group. Contrasting maxima were seen after median 30 (applicator and 38 (tumor minutes, in the potential core time of a multineedle procedure. Contrast influence on T1 thermometry for real-time monitoring of thermal impact was not significant (p = 0.068-0.715. CONCLUSION: Results strongly support anticipated promotive effects of Gd-EOB-DTPA for MR-guided percutaneous liver interventions by proving and quantifying the delineating effects for therapy-relevant elements in the procedure. Time benefit, cost

  14. Differentiation of hypertensive heart disease with hypertrophy and hepertrophic cardiomyopathy using consecutive time-course images of Gd-DTPA enhanced MRI

    Energy Technology Data Exchange (ETDEWEB)

    Ochiai, Kouichi; Isibashi, Yutaka; Shimada, Toshio; Tsukihashi, Hironori; Sato, Hidetoshi; Kitamura, Jun; Morioka, Shigefumi; Kawamitsu, Hideaki; Sugimura, Kazuro [Shimane Medical Univ., Izumo, Shimane (Japan)

    1996-03-01

    We used consecutive time-course Gd-DTPA contrast magnetic resonance images to differentiate hypertrophic cardiomyopathy (HCM) from hypertensive heart disease with hypertrophy (HHD). Seventeen patients with HCM, 6 patients with HHD and 5 normal subjects (control) were studied. ECG-gated MRI with 1.5T system was performed before and after intravenous injection of Gd-DTPA (0.1mmol/Kg) using spin echo sequence. Gd-DTPA enhanced MRI was repeated every 10 to 55 minutes. We measured signal intensity (SI) of midleft ventricular myocardium and skeletal muscle, and then calculated the ratio between myocardial SI and skeletal muscle SI. Myocardium was enhanced by Gd-DTPA in all patients. However, there was difference in the decay of enhancement effect by Gd-DTPA between HCM and HHD. The decay in HCM was more slowly than in both HHD and control. There was no difference in the decay between HHD and control. The difference in the decay between HCM and HHD became significant 25 minutes after Gd-DTPA injection and lasted until 55 minutes. We conclude that the time-course of the decay of enhancement effect by Gd-DTPA is helpful to differentiate HCM from HHD and the difference of the decay might reflect structural changes of myocardium. (author).

  15. Added value of Gd-EOB-DTPA-enhanced Hepatobiliary phase MR imaging in evaluation of focal solid hepatic lesions

    International Nuclear Information System (INIS)

    Haimerl, Michael; Wächtler, Max; Platzek, Ivan; Müller-Wille, Rene; Niessen, Christoph; Hoffstetter, Patrick; Schreyer, Andreas Georg; Stroszczynski, Christian; Wiggermann, Philipp

    2013-01-01

    Correct characterization of focal solid hepatic lesions has always been a challenge and is of great diagnostic and therapeutic relevance. The purpose of this study was to determine the added value of hepatobiliary phase images in Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for differentiating focal solid hepatic lesions. In this retrospective trial 84 consecutive patients underwent Gd-EOB-DTPA-enhanced MR examinations. MRI was conducted for 64 patients with malignant focal hepatic lesions (34 hepatocellular carcinoma (HCC), 30 metastases) and for 20 patients with benign hepatic lesions (14 focal nodular hyperplasia (FNH), 3 adenoma, 3 hemangioma). Five radiologists independently reviewed three sets of MR images by means of a 5-point confidence scale from score 1 (definitely benign) to score 5 (definitely malignant): set 1: unenhanced images; set 2: unenhanced and Gd-EOB-DTPA-enhanced dynamic images; set 3: hepatobiliary phase images in addition to set 2. Accuracy was assessed by the alternative free-response receiver operating characteristic curve (A z ) and the index of diagnostic performance was calculated. Diagnostic accuracy was significantly improved by the addition of Gd-EOB-DTPA-enhanced dynamic images: A z in set 1 was 0.708 and 0.833 in set 2 (P = 0.0002). The addition of hepatobiliary phase images increased the A z value to 0.941 in set 3 (set 3 vs set 2, P < 0.0001; set 3 vs set 1, P < 0.0001). The index of diagnostic performance was lowest in set 1 (45%), improved in set 2 (71%), and highest in set 3 (94%). Hepatobiliary phase images obtained after Gd-EOB-DTPA-enhanced dynamic MRI improve the differentiation of focal solid hepatic lesions

  16. Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives

    Directory of Open Access Journals (Sweden)

    Pedro Almendros

    2011-09-01

    Full Text Available The last decade has witnessed dramatic growth in the number of reactions catalyzed by gold complexes because of their powerful soft Lewis acid nature. In particular, the gold-catalyzed activation of propargylic compounds has progressively emerged in recent years. Some of these gold-catalyzed reactions in alkynes have been optimized and show significant utility in organic synthesis. Thus, apart from significant methodology work, in the meantime gold-catalyzed cyclizations in alkynol derivatives have become an efficient tool in total synthesis. However, there is a lack of specific review articles covering the joined importance of both gold salts and alkynol-based compounds for the synthesis of natural products and derivatives. The aim of this Review is to survey the chemistry of alkynol derivatives under gold-catalyzed cyclization conditions and its utility in total synthesis, concentrating on the advances that have been made in the last decade, and in particular in the last quinquennium.

  17. Cerebral and meningeal manifestations of AIDS: comparison of plain T2-weighted images and Gd-DTPA enhanced T1-weighted images in 105 patients

    International Nuclear Information System (INIS)

    Jochens, R.; Henkes, H.; Steinkamp, H.J.; Terstegge, K.; Hosten, N.; Ruf, B.; Schoerner, W.

    1994-01-01

    The purpose of the present study was to evaluate the potential of T1-weighted Gd-DTPA enhanced MR imaging in the diagnosis of cerebral manifestations of AIDS. 105 patients with AIDS were imaged with plain T2-weighted images as well as with Gd-DTPA enhanced T1-weighted pulse sequences. Our study revealed comparable sensitivities in the detection of morphological changes as shown on plain T2-weighted images and Gd-DTPA enhanced T1-weighted images in 55% of patients (normal and pathologic findings). Plain T2-weighted images were superior in 28.5% and provided significantly better results in 8.5% of patients. Gd-DTPA enhanced T1-weighted images were superior in only 5% cases and revealed significantly better results in 3%. As a result, T2-weighted plain images were superior in approximately 40% of patients concerning detection of morphologic changes. In almost 10% of patients with parechymal and meningeal lesions, Gd-DTPA enhanced T1-weighted images, however, were superior or even significantly better compared to T2-weighted plain images. The detection of morphologic changes in MR imaging can be further increased with Gd-DTPA. With regard to differential diagnosis and diesease activity, plain T2-weighted images and Gd-DTPA enhanced T1-weighted images revealed comparable results in 42% of patients (normal and pathologic findings). T2-weighted plain images were superior in 2% of cases whereas Gd-DTPA enhanced T1-weighted images were superior in as much as 56% of patient. MR imaging enhanced with Gd-DTPA yielded additional information on disease activity in 73% of patients with pathologic findings in the cerebral parechyma and the meninges. The surplus of information also refers to the etiology of cerebral pathology and differential diagnosis. Because of the frequency of cerebral manifestations in AIDS, early diagnosis for initiation of therapy and follow-up studies to monitor therapy are crucial. (orig./MG) [de

  18. Derivation of energy-based base shear force coefficient considering hysteretic behavior and P-delta effects

    Science.gov (United States)

    Ucar, Taner; Merter, Onur

    2018-01-01

    A modified energy-balance equation accounting for P-delta effects and hysteretic behavior of reinforced concrete members is derived. Reduced hysteretic properties of structural components due to combined stiffness and strength degradation and pinching effects, and hysteretic damping are taken into account in a simple manner by utilizing plastic energy and seismic input energy modification factors. Having a pre-selected yield mechanism, energy balance of structure in inelastic range is considered. P-delta effects are included in derived equation by adding the external work of gravity loads to the work of equivalent inertia forces and equating the total external work to the modified plastic energy. Earthquake energy input to multi degree of freedom (MDOF) system is approximated by using the modal energy-decomposition. Energy-based base shear coefficients are verified by means of both pushover analysis and nonlinear time history (NLTH) analysis of several RC frames having different number of stories. NLTH analyses of frames are performed by using the time histories of ten scaled ground motions compatible with elastic design acceleration spectrum and fulfilling duration/amplitude related requirements of Turkish Seismic Design Code. The observed correlation between energy-based base shear force coefficients and the average base shear force coefficients of NLTH analyses provides a reasonable confidence in estimation of nonlinear base shear force capacity of frames by using the derived equation.

  19. Earthquake magnitudes based on Coda-Derived Moment-Rate Spectra in Taiwan

    Science.gov (United States)

    Tu, F.; Gung, Y.; Yoo, S.; Rhie, J.

    2010-12-01

    We use the coda-derived moment-rate spectra method to estimate earthquake magnitudes in Taiwan. We extract coda-envelope at several frequency bands ranging from 0.03 to 8.0 hz using the horizontal component of broad-band waveform data recorded by BATS (Broadband Array in Taiwan for Siemology). We derived synthetic coda-envelope using various empirical frequency-dependent corrections mainly based upon Mayeda et al. (2003), which may account for all propagation, site and S-to-coda transfer function effects. After proper calibration and distance-corrections, the dimensionless coda amplitudes are used to determine the earthquake magnitude and source spectra. Selected events with magnitudes between 4 and 6 that occurred in 2009 are used to derive the empirical corrections and calibrations. We present detailed results of each procedure. Moreover, with the empirical corrections, we apply this measurement to an expanded data set and compare the derived coda-magnitude with other magnitude scales derived from conventional methods.

  20. Entropy-based derivation of generalized distributions for hydrometeorological frequency analysis

    Science.gov (United States)

    Chen, Lu; Singh, Vijay P.

    2018-02-01

    Frequency analysis of hydrometeorological and hydrological extremes is needed for the design of hydraulic and civil infrastructure facilities as well as water resources management. A multitude of distributions have been employed for frequency analysis of these extremes. However, no single distribution has been accepted as a global standard. Employing the entropy theory, this study derived five generalized distributions for frequency analysis that used different kinds of information encoded as constraints. These distributions were the generalized gamma (GG), the generalized beta distribution of the second kind (GB2), and the Halphen type A distribution (Hal-A), Halphen type B distribution (Hal-B) and Halphen type inverse B distribution (Hal-IB), among which the GG and GB2 distribution were previously derived by Papalexiou and Koutsoyiannis (2012) and the Halphen family was first derived using entropy theory in this paper. The entropy theory allowed to estimate parameters of the distributions in terms of the constraints used for their derivation. The distributions were tested using extreme daily and hourly rainfall data. Results show that the root mean square error (RMSE) values were very small, which indicated that the five generalized distributions fitted the extreme rainfall data well. Among them, according to the Akaike information criterion (AIC) values, generally the GB2 and Halphen family gave a better fit. Therefore, those general distributions are one of the best choices for frequency analysis. The entropy-based derivation led to a new way for frequency analysis of hydrometeorological extremes.

  1. Use of activable cations as tracers in groundwater hydrology. The case of DTPA-Indium

    International Nuclear Information System (INIS)

    Lumu, Badimbayi Matu.

    1978-01-01

    The possibilities of EDTA, CDTA and DTPA metallic complexes use as activable groundwater, tracers are discussed. Indium, which has good nuclear caracteristics for activation analysis and forms complexes of great stability with polyamino carboxylic acid has been for Laboratory and field studies. For corporative studies, Rhodomine B, a fluorescent tracer have been studied together with Indium complexes. In laboratory retention studies have been carried with In-EDTA, Iodine 131 and Rhodomine B, as tracers and bentonite, zeolite 13X and Dowex-1 and Dowex-50 as sorbents. As field studies, drainage evolution flow and resident time distribution of tracers substances in water, have been carried, under artificial rain conditions realized by aspersion. Results from field studies showed good characteristics of Indium Complexes especially in very absorbent medium (argilaceous limon) where their restitution balance were superior to that of Rhodomine B

  2. An analysis of 'obstructive type' renography cases in 99mTc-DTPA renal dynamic imaging

    International Nuclear Information System (INIS)

    Wang Xinhui

    1991-01-01

    99m Tc-DTPA renal dynamic imaging and computed renography were performed in 61 cases. Renal blood perfusion imaging was also performed in some cases. Renography curves, which did not decrease in 20 min on all 61 cases (90 kidneys), are analysed in combination with renal dynamic imaging and renal perfusion imaging. 11 cases (12 kidneys) are only obstructive. 24 cases (32 kidneys) are obstructive and renal function impaired. Other 26 cases (46 kidneys) are renal function impaired or blood perfusion insufficient, but are not obstructive. The result demonstrated that the obstructive type renography may be obstructive or may be renal function impaired or blood supply insufficient. An analysis of renography in combination with renal dynamic imaging and blood perfusion imaging is more accurate than renography alone

  3. Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors

    DEFF Research Database (Denmark)

    Larsson, H B; Stubgaard, M; Frederiksen, J L

    1990-01-01

    In this study quantitation of the degree of deficiency of the blood-brain barrier (BBB) in patients with multiple sclerosis or brain tumors, by using MRI, is shown to be possible. As a measure of permeability of the BBB to Gadolinium-DTPA (Gd-DTPA) the flux per unit of distribution volume per unit...... of brain mass was used. This quantity was found by introducing the longitudinal relaxation rate (R1) as a measure of concentration of Gd-DTPA in the brain tissue in the mathematical model for the transcapillary transport over the BBB. High accordance between the observed data points and the model was found...

  4. In-vivo behavior of tin-117m(2+ and 4+)-labeled DTPA and MDP. Preparation, tissue distribution in mice, and imaging in dogs

    International Nuclear Information System (INIS)

    Srivastava, S.C.; Richards, P.; Meinken, G.E.; Som, P.; Knapp, F.F. Jr.; Butler, T.A.

    1982-01-01

    Tissue distribution in mice of stannous chloride (pH 2), and of stannous as well as stannic chelates of MDP and DTPA is described. The bone-to-tissue ratios of these compounds are evaluated. High bone uptake of all these compounds point out the high affinity of tin for bone despite the chemically diverse ligands. Whole body autoradiographs of mice injected with tin-117m(IV)-DTPA demonstrate the almost exclusive localization of tin-117m activity in bone. Clarity of bone images in a dog, obtained up to 15 days following the injection of tin-117m(IV)-DTPA is demonstrated

  5. Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives.

    Science.gov (United States)

    Taha, Muhammad; Shah, Syed Adnan Ali; Afifi, Muhammad; Imran, Syahrul; Sultan, Sadia; Rahim, Fazal; Khan, Khalid Mohammed

    2018-04-01

    We have synthesized seventeen Coumarin based derivatives (1-17), characterized by 1 HNMR, 13 CNMR and EI-MS and evaluated for α-glucosidase inhibitory potential. Among the series, all derivatives exhibited outstanding α-glucosidase inhibition with IC 50 values ranging between 1.10 ± 0.01 and 36.46 ± 0.70 μM when compared with the standard inhibitor acarbose having IC 50 value 39.45 ± 0.10 μM. The most potent derivative among the series is derivative 3 having IC 50 value 1.10 ± 0.01 μM, which are many folds better than the standard acarbose. The structure activity relationship (SAR) was mainly based upon by bring about difference of substituent's on phenyl part. Molecular docking studies were carried out to understand the binding interaction of the most active compounds. Copyright © 2018 Elsevier Inc. All rights reserved.

  6. Immunoscintigraphy using 111In-DTPA labeled monoclonal antibodies: Comparison between ETC and planar imaging

    International Nuclear Information System (INIS)

    Happ, J.; Baum, R.P.; Frohn, J.; Weimer, B.; Hoer, G.; Halbsguth, A.; Lochner, B.; Brandhorst, I.

    1987-01-01

    The present study was done in order to examine if the use of 111 In-DTPA-labeled MAb fragments in place of 131 I-labeled MAb fragments increases the sensitivity of tomographic immunoscintigraphy to reach the level of that of planar imaging techniques. In 11 patients with various primary tumors, local recurrences or metastases [colorectal carcinoma (n=7), ovarian carcinoma (n=2), papillary thyroid carcinoma (n=1), undifferentiated carcinoma of the lung (n=1)], immuniscintigraphy (IS) was carried out using 111 In-DTPA-labeled F(ab') 2 fragments of various MAbs (anti-CEA, OC 125, anti-hTG) and planar and tomographic imaging were compared intraindividually. By conventional diagnostic procedures, the presence of a tumor mass was confirmed (transmission computer tomography, ultrasound) or verified ( 131 I whole-body scintigraphy, histology) in all cases. Immunoscintigraphy was positive in 9 out of 11 cases by ECT and in 10 out of 11 cases by planar imaging. When using 111 In-labeled MAb fragments, intraindividual comparison of ECT and planar imaging resulted in a similar sensitivity. The increased sensitivity of ECT using this tracer in contrast to 131 I-labeled MAb fragments may be attributed to the fact that the physical properties of 111 In are much more suitable for the gamma cameras most commonly used (single detector, 3/8'' crystal); using 111 In-labelled MAb fragments, count rates sufficient for ECT can be obtained within a reasonable acquisition time. This allows to combine IS with the advantages of ECT regarding tumour localization and prevention of artefacts due to superposition of background. (orig.) [de

  7. Tin-117m(4+)-DTPA for palliation of pain from osseous metastases: A pilot study

    International Nuclear Information System (INIS)

    Atkins, H.L.; Mausner, L.F.; Srivastava, S.C.

    1995-01-01

    The physical and biological attributes of 117m Sn(4+)-DTPA indicate that it should be an effective agent for palliative therapy of painful bony metastatic disease. The aim of this study was to evaluate whether or not this agent could effectively reduce pain while sparing the hemopoietic marrow from adverse effects. Fifteen patients (10 males and 5 females) with painful bony metastases from various primary cancers were included in the study. Seven patients received 1.22 to 3.11 MBq/kg of 117m Sn intravenously (Group 1) and eight patients received 4.85 to 5.77 MBq/kg (Group 2). All but one were treated as outpatients and followed for a minimum of 2 mo. In the first group, pain relief was nonassessable in four patients because of death or additional treatment of soft-tissue disease by another modality. One patient had no relief of pain, one had complete relief of pain and one had transient relief of pain. No myelotoxicity was observed. For Group 2, three patients achieved complete relief of pain, two good relief, two partial relief and one began to experience pain relief when he suffered a pathological fracture 2 mo most-treatment. None of these patients had myelotoxicity. Tin-117m(4+)-DTPA can reduce pain from metastatic disease to bone without inducing adverse reactions related to bone marrow. Further studies are needed to assess tolerance levels for the bone marrow and to evaluate response rates and duration of effect. 6 refs., 4 figs., 4 tabs

  8. MRT of scaphoid pseudo-arthrosis using Gd-DTPA. Staging and clinical correlation; MRT der Skaphoidpseudarthrose mit Gd-DTPA. Stadieneinteilung und klinische Korrelation

    Energy Technology Data Exchange (ETDEWEB)

    Vogl, T.J. [Freie Univ. Berlin (Germany). Strahlenklinik und Poliklinik; Beutel, F. [Freie Univ. Berlin (Germany). Strahlenklinik und Poliklinik; Wilhelm, K. [LMU Muenchen (Germany). Abt. fuer Handchirurgie; Tempka, A. [Freie Univ. Berlin (Germany). Klinik fuer Unfall- und Wiederherstellungschirurgie; Schedel, H. [Freie Univ. Berlin (Germany). Strahlenklinik und Poliklinik; Haas, R. [Freie Univ. Berlin (Germany). Strahlenklinik und Poliklinik; Felix, R. [Freie Univ. Berlin (Germany). Strahlenklinik und Poliklinik

    1994-11-01

    During a period of two years, 134 patients with pseudo-arthrosis of the scaphoid were examined by conventional radiography and by MRI in the course of a prospective study. The aim of the study was to define radiological staging using contrast enhanced MRI in order to improve the prognostic criteria. All MRI examinations were carried out with a 1.5 Tesla scanner (SP63) using a surface coil and T{sub 1} weighted spin echo sequences in sagittal and frontal projection and frontal FLASH T{sub 2}-sequences and axial spin echo T{sub 2} sequences. The T{sub 1} weighted SE sequences in frontal projection were carried out before and after iv contrast (0.1 mmol Gd-DTPA/kg KG). All sequences were compared with conventional radiographs and the operative findings. Eight patients in stage 0 showed high signal intensity of both fragments in T{sub 1} weighted SE sequences and at surgery there was good vascularisation. In 22 cases there was reduced signal intensity in at least one fragment (stage I). 45 patients with scaphoid pseudo-arthrosis showed complete signal loss but marked contrast uptake with still vital nuclei at surgery (stage II). In 22 patients, there was no increase in signal intensity after contrast and complete loss of vitality of the fragments at surgery. Staging was not possible in 37 patients because of previous operative intervention. The use of contrast enhanced MRI provides additional information compared with conventional radiography or plain MRI. (orig.) [Deutsch] Im Rahmen einer prospektiven Studie wurden in einem Zeitraum von 2 Jahren 134 Patienten mit einer Skaphoidpseudarthrose (SPA) vergleichend konventionell roentgenologisch und magnetresonanztomographisch untersucht. Ziel der Studie war die Erstellung einer klinisch radiologischen Stadieneinteilung mit Hilfe der kontrastverstaerkten MRT zur Verbesserung von Prognosekriterien. Alle MRT-Untersuchungen wurden an einem 1,5 Tesla-Geraet (SP63) mittels einer Oberflaechenspule unter Verwendung von T{sub 1

  9. Preparation of {sup 166} Dy/{sup 166} Ho DTPA-bis biotin as a system of In vivo generator; Preparacion de {sup 166} Dy/{sup 166} Ho DTPA-bis biotina como un sistema de generador In vivo

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez V, M.R

    2003-07-01

    The objective of this work was to synthesize the complex {sup 166} Dy/{sup 166} Ho - diethylen triamine pentaacetic-bis Biotin ({sup 166} Dy/{sup 166} Ho DTPA-bis Biotin) to evaluate its potential as a new radiopharmaceutical in directed radiotherapy. The Dysprosium-166 was obtained for neutron irradiation of {sup 164} Dy{sub 2}0{sub 3} in the TRIGA Mark III reactor. The labelled was carried out in aqueous solution to p H 8.0 for addition of {sup 166} Dy Cl{sub 3} to the diethylen triamine pentaacetic-{alpha}, {omega}-bis Biotin (DTPA-bis Biotin). The radiochemical purity was determined for HPLC and ITLC. The biological integrity of the marked biotin is evaluated by the biological recognition of the avidin for HPLC - molecular exclusion with and without avidin addition. The studies of stability in vitro were made in dilutions of saline solution to 0.9% and with human serum at 37 C incubated 1 and 24 hours. The complex {sup 166} Dy/{sup 166} Ho DTPA-bis Biotin was obtained with a radiochemical purity of 99.1 {+-} 0.6%. The biological recognition of the complex {sup 166} Dy/{sup 166} Ho DTPA-bis Biotin for the avidin it doesn't affect the labelling procedure. The studies in vitro demonstrated that the {sup 166} Dy/{sup 166} Ho DTPA-bis Biotin is stable after the dilution in saline solution and in human serum that there is not translocation of the one radionuclide subsequent son to the beta decay of the {sup 166} Dy that could produce the {sup 166} Ho{sup 3+} liberation. The studies of Biodistribution in healthy mice demonstrated that the one complex {sup 166} Dy/{sup 166} Ho DTPA-bis Biotin have a high renal distribution. In conclusion the radiolabelled biotin in this investigation has the appropriate properties to be used as an In vivo generator system stable for directed radiotherapy. (Author)

  10. Electrochemical and optical sugar sensors based on phenylboronic acid and its derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Egawa, Yuya; Seki, Toshinobu [Faculty of Pharmaceutical Sciences, Josai University, Keyakidai, Sakado, Saitama 350-0295 (Japan); Takahashi, Shigehiro [Graduate School of Pharmaceutical Sciecnes, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578 (Japan); Anzai, Jun-ichi, E-mail: junanzai@mail.pharm.tohoku.ac.jp [Graduate School of Pharmaceutical Sciecnes, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578 (Japan)

    2011-10-10

    Recent progress in electrochemical and optical sugar sensors based on phenylboronic acid (PBA) and its derivatives as recognition components is reviewed. PBAs are known to bind diol compounds including sugars to form cyclic boronate esters that are negatively charged as a result of the addition of OH{sup -} ions from solution. Based on the formation of PBA charged species, sugars and their derivatives can be detected by means of electrochemical and optical techniques. For the development of PBA-based electrochemical sensing systems or sensors, PBA is modified with a redox-active marker, because PBA itself is electrochemically inactive, and ferrocene derivatives are often employed for this purpose. Ferrocene-modified PBAs have been used as redox-active additives in solution for the electrochemical detection of sugars and derivatives. PBA-modified electrodes have also been constructed as reagentless electrochemical sensors, where PBAs are immobilized on the surface of metal and carbon electrodes through mainly two routes: as a self-assembled monolayer film and as a polymer thin film. PBA-modified electrodes can be successfully used to detect sugars and derivatives through potentiometric and voltammetric responses. In addition, PBA-modified electrodes can be used for the immobilization of glycoenzymes on an electrode surface by the formation of boronate esters with carbohydrate chains in the glycoenzymes, thus resulting in enzyme biosensors. For the development of PBA-based optical sensors, a variety of chromophores and fluorophores have been coupled with PBA. Azobenzene dyes have been most frequently used for the preparation of colorimetric sugar sensors, in which the absorption wavelength and intensity of the dye are dependent on the type and concentration of added sugars. The sensitivity of the sensors is significantly improved based on multi-component systems in which alizalin red S, pyrocatechol violet, starch-iodine complex, and cyclodextrin are employed as

  11. Electrochemical and optical sugar sensors based on phenylboronic acid and its derivatives

    International Nuclear Information System (INIS)

    Egawa, Yuya; Seki, Toshinobu; Takahashi, Shigehiro; Anzai, Jun-ichi

    2011-01-01

    Recent progress in electrochemical and optical sugar sensors based on phenylboronic acid (PBA) and its derivatives as recognition components is reviewed. PBAs are known to bind diol compounds including sugars to form cyclic boronate esters that are negatively charged as a result of the addition of OH - ions from solution. Based on the formation of PBA charged species, sugars and their derivatives can be detected by means of electrochemical and optical techniques. For the development of PBA-based electrochemical sensing systems or sensors, PBA is modified with a redox-active marker, because PBA itself is electrochemically inactive, and ferrocene derivatives are often employed for this purpose. Ferrocene-modified PBAs have been used as redox-active additives in solution for the electrochemical detection of sugars and derivatives. PBA-modified electrodes have also been constructed as reagentless electrochemical sensors, where PBAs are immobilized on the surface of metal and carbon electrodes through mainly two routes: as a self-assembled monolayer film and as a polymer thin film. PBA-modified electrodes can be successfully used to detect sugars and derivatives through potentiometric and voltammetric responses. In addition, PBA-modified electrodes can be used for the immobilization of glycoenzymes on an electrode surface by the formation of boronate esters with carbohydrate chains in the glycoenzymes, thus resulting in enzyme biosensors. For the development of PBA-based optical sensors, a variety of chromophores and fluorophores have been coupled with PBA. Azobenzene dyes have been most frequently used for the preparation of colorimetric sugar sensors, in which the absorption wavelength and intensity of the dye are dependent on the type and concentration of added sugars. The sensitivity of the sensors is significantly improved based on multi-component systems in which alizalin red S, pyrocatechol violet, starch-iodine complex, and cyclodextrin are employed as

  12. PET imaging of HER1-expressing xenografts in mice with {sup 86}Y-CHX-A''-DTPA-cetuximab

    Energy Technology Data Exchange (ETDEWEB)

    Nayak, Tapan K.; Regino, Celeste A.S.; Milenic, Diane E.; Garmestani, Kayhan; Baidoo, Kwamena E.; Brechbiel, Martin W. [National Institutes of Health, Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, Bethesda, MD (United States); Wong, Karen J. [National Institutes of Health, Molecular Imaging Program, National Cancer Institute, Bethesda, MD (United States); Szajek, Lawrence P. [National Institutes of Health, PET Department, Warren G. Magnuson Clinical Center, Bethesda, MD (United States)

    2010-07-15

    Cetuximab is a recombinant, human/mouse chimeric IgG{sub 1} monoclonal antibody that binds to the epidermal growth factor receptor (EGFR/HER1). Cetuximab is approved for the treatment of patients with HER1-expressing metastatic colorectal cancer. Limitations in currently reported radiolabeled cetuximab for PET applications prompted the development of {sup 86}Y-CHX-A''-DTPA-cetuximab as an alternative for imaging HER1-expressing cancer. {sup 86}Y-CHX-A''-DTPA-cetuximab can also serve as a surrogate marker for {sup 90}Y therapy. Bifunctional chelate, CHX-A''-DTPA was conjugated to cetuximab and radiolabeled with {sup 86}Y. In vitro immunoreactivity was assessed in HER1-expressing A431 cells. In vivo biodistribution, PET imaging and noncompartmental pharmacokinetics were performed in mice bearing HER1-expressing human colorectal (LS-174T and HT29), prostate (PC-3 and DU145), ovarian (SKOV3) and pancreatic (SHAW) tumor xenografts. Receptor blockage was demonstrated by coinjection of either 0.1 or 0.2 mg cetuximab. {sup 86}Y-CHX-A''-DTPA-cetuximab was routinely prepared with a specific activity of 1.5-2 GBq/mg and in vitro cell-binding in the range 65-75%. Biodistribution and PET imaging studies demonstrated high HER1-specific tumor uptake of the radiotracer and clearance from nonspecific organs. In LS-174T tumor-bearing mice injected with {sup 86}Y-CHX-A''-DTPA-cetuximab alone, {sup 86}Y-CHX-A''-DTPA-cetuximab plus 0.1 mg cetuximab or 0.2 mg cetuximab, the tumor uptake values at 3 days were 29.3 {+-} 4.2, 10.4 {+-} 0.5 and 6.4 {+-} 0.3%ID/g, respectively, demonstrating dose-dependent blockage of the target. Tumors were clearly visualized 1 day after injecting 3.8-4.0 MBq {sup 86}Y-CHX-A''-DTPA-cetuximab. Quantitative PET revealed the highest tumor uptake in LS-174T (29.55 {+-} 2.67%ID/cm{sup 3}) and the lowest tumor uptake in PC-3 (15.92 {+-} 1.55%ID/cm{sup 3}) xenografts at 3 days after injection

  13. Lubricity of bio-based lubricant derived from chemically modified jatropha methyl ester

    OpenAIRE

    N.W.M. Zulkifli; H.H. Masjuki; M.A. Kalam; R. Yunus; S.S.N. Azman

    2014-01-01

    Many studies have been undertaken with a view to using chemically modified vegetable oil as a bio-based lubricant. This research focused on tribological properties of trimethylolpropane (TMP) ester, which is derived from renewable resource. This TMP ester was produced from jatropha methyl ester; it is biodegradable and has high lubricity properties. Two different conditions of lubrication are being investigated: extreme pressure and anti-wear. It was found that the TMP ester (Jatropha) has be...

  14. Sensitivity of diamond-capped impedance transducer to Tröger’s base derivatives

    Czech Academy of Sciences Publication Activity Database

    Stehlík, Štěpán; Ižák, Tibor; Kromka, Alexander; Dolenský, B.; Havlík, M.; Rezek, Bohuslav

    2012-01-01

    Roč. 4, č. 8 (2012), s. 3860-3865 ISSN 1944-8244 R&D Projects: GA ČR(CZ) GBP108/12/G108 Institutional research plan: CEZ:AV0Z10100521 Keywords : Tröger’s base derivative * nanocrystalline diamond * chemical sensor * impedance spectroscopy * surface conductivity Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 5.008, year: 2012

  15. Synthesis and research of derived oxazol-5-ones based on α,β – unsaturated ketones

    Directory of Open Access Journals (Sweden)

    Сергей Александрович Петров

    2015-11-01

    Full Text Available The article deals with the production of new fluorescent dyes derived oxazol-5-ones based on α, β-unsaturated ketones, as well as confirmation of the structure of the compounds obtained using NMR and IR spectroscopy. The dyes of this series are relevant because one of the important practical problems in organic chemistry and chemical technology is currently seeking new fluorescent dyes for dyeing polyester materials and polymers

  16. The Circumpolar Arctic Vegetation Map: AVHRR-derived base maps, environmental controls, and integrated mapping procedures

    Science.gov (United States)

    D. A. WALKER; W. A. GOULD; MAIERH. A.; M. K. RAYNOLDS

    2002-01-01

    A new false-colour-infrared image derived from biweekly 1993 and 1995 Advanced Very High Resolution Radiometer (AVHRR) data provides a snow-free and cloud-free base image for the interpretation of vegetation as part of a 1:7.5M-scale Circumpolar Arctic Vegetation Map (CAVM). A maximum-NDVI (Normalized DiVerence Vegetation Index) image prepared from the same data...

  17. Design and application of natural product derived probes for activity based protein profiling

    OpenAIRE

    Battenberg, Oliver Alexander

    2015-01-01

    The identification of new antibacterial protein targets by activity based protein profiling (ABPP) is an important approach to face the increasing emergence of resistant bacteria. The scope of this work focuses on three new strategies for the labeling of antibacterial protein-targets with natural product derived ABPP-probes: A.) Evaluation of the intrinsic photo-reactivity of α-pyrones and pyrimidones for use as photo-crosslinkers. B.) Synthesis of a benzophenone-tag that combines photo-cross...

  18. Interlaminar Stresses by Refined Beam Theories and the Sinc Method Based on Interpolation of Highest Derivative

    Science.gov (United States)

    Slemp, Wesley C. H.; Kapania, Rakesh K.; Tessler, Alexander

    2010-01-01

    Computation of interlaminar stresses from the higher-order shear and normal deformable beam theory and the refined zigzag theory was performed using the Sinc method based on Interpolation of Highest Derivative. The Sinc method based on Interpolation of Highest Derivative was proposed as an efficient method for determining through-the-thickness variations of interlaminar stresses from one- and two-dimensional analysis by integration of the equilibrium equations of three-dimensional elasticity. However, the use of traditional equivalent single layer theories often results in inaccuracies near the boundaries and when the lamina have extremely large differences in material properties. Interlaminar stresses in symmetric cross-ply laminated beams were obtained by solving the higher-order shear and normal deformable beam theory and the refined zigzag theory with the Sinc method based on Interpolation of Highest Derivative. Interlaminar stresses and bending stresses from the present approach were compared with a detailed finite element solution obtained by ABAQUS/Standard. The results illustrate the ease with which the Sinc method based on Interpolation of Highest Derivative can be used to obtain the through-the-thickness distributions of interlaminar stresses from the beam theories. Moreover, the results indicate that the refined zigzag theory is a substantial improvement over the Timoshenko beam theory due to the piecewise continuous displacement field which more accurately represents interlaminar discontinuities in the strain field. The higher-order shear and normal deformable beam theory more accurately captures the interlaminar stresses at the ends of the beam because it allows transverse normal strain. However, the continuous nature of the displacement field requires a large number of monomial terms before the interlaminar stresses are computed as accurately as the refined zigzag theory.

  19. Syntheses of Azo-Imine Derivatives from Vanillin as an Acid Base Indicator

    Directory of Open Access Journals (Sweden)

    Bambang Purwono

    2013-05-01

    Full Text Available Preparations of azo, imine and azo-imine derivatives from vanillin as an indicator of acid-base titration have been carried out. The azo derivative of 4-hydroxy-3-methoxy-5-(phenylazobenzaldehyde 2 was produced by diazotitation reaction of vanillin in 37.04% yield. The azo product was then refluxed with aniline in ethanol to yield azo-imine derivatives, 2-methoxy-6-(phenylazo-4-((phenyliminomethylphenol 1 in 82.21% yield. The imine derivative, 2-methoxy-4-((phenyliminomethyl-phenol 3 was obtained by refluxing of vanillin and aniline mixture in ethanol solvent and produced 82.17% yield. The imine product was then reacted with benzenediazonium chloride salt. However, the products indicated hydrolyzed product of 4-hydroxy-3-methoxy-5-(phenylazobenzaldehyde 2 in 22.15% yield. The 2-methoxy-4-((phenyliminomethylphenol 2 could be used as an indicator for titration of NaOH by H2C2O4 with maximum concentration of H2C2O4 0.1 M while the target compound 1 could be used as titration indicator for titration of NaOH with H2C2O4 with same result using phenolphthalein indicator.

  20. New method for numerical approximations of vector derivatives based on digital signal processing techniques

    Science.gov (United States)

    Brice, Henry; Ahmed, Mohammed Z.

    2012-05-01

    Accurate propagation models are required for predicting the propagation of electromagnetic waves within complex environments. This paper proposes the use of a new method to accurately compute the divergence and curl of electromagnetic fields. The computation of the derivatives of vector fields is normally approximated using numerical methods such as the Finite-Dierence Time-Domain Method (FDTD), the Finite Integration Technique and the Multi-Resolution Time-Domain Method. These methods are all limited in terms of their accuracy, resolution, computational efficiency and numerical stability. This paper introduces a new method for computing derivatives based on Two-Dimensional (2D) Digital Signal Processing (DSP) techniques. The method involves computing a numerical approximation of the derivative of a function by considering the frequency domain definition of the derivative and designing a 2Dfinite impulse response (FIR) filter that implements the differentiation. Appropriate windowing functions are used to ensure that the FIR response is as close to the ideal 2D differentiator response as possible. This paper provides an example where the curl of a vectorfield is determined using this method and accuracy within a few percent is achieved. The proposed innovative method can be extended to three dimensions and used to find numerical solutions of Maxwells Equations, thus allowing it to be applied to the design of accurate propagation models.

  1. Design of quadrature mirror filter bank using Lagrange multiplier method based on fractional derivative constraints

    Directory of Open Access Journals (Sweden)

    B. Kuldeep

    2015-06-01

    Full Text Available Fractional calculus has recently been identified as a very important mathematical tool in the field of signal processing. Digital filters designed by fractional derivatives give more accurate frequency response in the prescribed frequency region. Digital filters are most important part of multi-rate filter bank systems. In this paper, an improved method based on fractional derivative constraints is presented for the design of two-channel quadrature mirror filter (QMF bank. The design problem is formulated as minimization of L2 error of filter bank transfer function in passband, stopband interval and at quadrature frequency, and then Lagrange multiplier method with fractional derivative constraints is applied to solve it. The proposed method is then successfully applied for the design of two-channel QMF bank with higher order filter taps. Performance of the QMF bank design is then examined through study of various parameters such as passband error, stopband error, transition band error, peak reconstruction error (PRE, stopband attenuation (As. It is found that, the good design can be obtained with the change of number and value of fractional derivative constraint coefficients.

  2. Derived limits for radiological protection against ionizing radiation based on ICRP-60 recommendations

    International Nuclear Information System (INIS)

    Jang, Si Young; Lee, Byung Soo

    2000-01-01

    In Korea the dose limits are reduced and are set at the ICRP-60 limits. However, derived limits tabulated as MPC in air and water are sill specified in Notice Nol 98-12. There are some discrepancies between the primary dose limits and MPCs in air and water. Therefore, in order to accept ICRP-60 recommendations fully, derived limits such as ALI, DAC, ECL for radiological protection against ionizing radiation based on ICRP-60 recommendations were calculated using modified methods of those of 10 CFR part 20, dose limits and committed effective dose coefficients of the Basic Safety Standards of the IAEA. The derived limits in this study were also compared with those prescribed in 10 CFR part 20 as well as MPCs of Notice No.98-12 in order to analyze the impact of implementing derived limits on nuclear facilities. ECLs in air and water for the control of radioactive discharge into the environment in this study are shown to have lower values (i.e. more conservative), for most part, than those in Notice No. 98-12. Especially, for uranium elements, ECLs in water are approximately a magnitude in the order of two lower than those in Notice No. 98-12. (author)

  3. Intraindividual comparison of T1 relaxation times after gadobutrol and Gd-DTPA administration for cardiac late enhancement imaging

    Energy Technology Data Exchange (ETDEWEB)

    Doeblin, Patrick, E-mail: Patrick.doeblin@charite.de [Department of Cardiology, Charité – Universitätsmedizin Berlin, Charité Campus Benjamin Franklin, Berlin (Germany); Schilling, Rene, E-mail: rene.schilling@charite.de [Department of Radiology, Charité – Universitätsmedizin Berlin, Charité Campus Mitte, Berlin (Germany); Wagner, Moritz, E-mail: moritz.wagner@charite.de [Department of Radiology, Charité – Universitätsmedizin Berlin, Charité Campus Mitte, Berlin (Germany); Luhur, Reny, E-mail: renyluhur@yahoo.com [Department of Radiology, Charité – Universitätsmedizin Berlin, Charité Campus Mitte, Berlin (Germany); Huppertz, Alexander, E-mail: alexander.huppertz@charite.de [Department of Radiology, Charité – Universitätsmedizin Berlin, Charité Campus Mitte, Berlin (Germany); Imaging Science Institute, Charité, Berlin (Germany); Hamm, Bernd, E-mail: bernd.hamm@charite.de [Department of Radiology, Charité – Universitätsmedizin Berlin, Charité Campus Mitte, Berlin (Germany); Taupitz, Matthias, E-mail: matthias.taupitz@harite.de [Department of Radiology, Charité – Universitätsmedizin Berlin, Charité Campus Mitte, Berlin (Germany); and others

    2014-04-15

    Purpose: To evaluate T1-relaxation times of chronic myocardial infarction (CMI) using gadobutrol and gadopentetate dimeglumine (Gd-DTPA) over time and to determine the optimal imaging window for late enhancement imaging with both contrast agents. Material and methods: Twelve patients with CMI were prospectively included and examined on a 1.5 T magnetic resonance (MR) system using relaxivity-adjusted doses of gadobutrol (0.15 mmol/kg) and Gd-DTPA (0.2 mmol/kg) in random order. T1-relaxation times of remote myocardium (RM), infarcted myocardium (IM), and left ventricular cavity (LVC) were assessed from short-axis TI scout imaging using the Look–Locker approach and compared intraindividually using a Wilcoxon paired signed-rank test (α < 0.05). Results: Within 3 min of contrast agent administration (CA), IM showed significantly lower T1-relaxation times than RM with both contrast agents, indicating beginning cardiac late enhancement. Differences between gadobutrol and Gd-DTPA in T1-relaxation times of IM and RM were statistically not significant through all time points. However, gadobutrol led to significantly higher T1-relaxation times of LVC than Gd-DTPA from 6 to 9 min (220 ± 15 ms vs. 195 ± 30 ms p < 0.01) onwards, resulting in a significantly greater ΔT1 of IM to LVC at 9–12 min (−20 ± 35 ms vs. 0 ± 35 ms, p < 0.05) and 12–15 min (−25 ± 45 ms vs. −10 ± 60 ms, p < 0.05). Using Gd-DTPA, comparable ΔT1 values were reached only after 25–35 min. Conclusion: This study indicates good delineation of IM to RM with both contrast agents as early as 3 min after administration. However, we found significant differences in T1 relaxation times with greater ΔT1 IM–LVC using 0.15 mmol/kg gadobutrol compared to 0.20 mmol/kg Gd-DTPA after 9–15 min post-CA suggesting earlier differentiability of IM and LVC using gadobutrol.

  4. Role of 99MTc-DTPA renal scintigraphy using gates protocol with extended acquisition time in evaluation of the function of pre-operative donor kidneys and post-operative remaining kidney

    International Nuclear Information System (INIS)

    Trinh Thi Minh Chau; Nguyen Xuan Canlh; Le Huu tam; Truong Quang Xuan

    2004-01-01

    Introduction: Radionuclide Methods have been extensively used in kidney transplantation. This non-invasive technique provides quantitative analysis of total and individual renal function as well as assessment of urinary outflow tract. Aim of this study was to evaluate renal function of potential kidney-donors and follow up post-nephrectomy kidney-donors by 99mTc-DTPA renal scintigraphy using Gates protocol with extended acquisition. MATERIALS AND Methods: This study included 72 living kidney donors. In addition to routine laboratory and radiological evaluations, a 99mTc-DTPA dynamic renal scintigraphy was acquired 15 second per frame for 30 minutes. Glomerular filtration rate (GFR) was calculated based on Gates protocol. Urinary outflow tract was assayed by renogram generated and consecutive dynamic renal images of up to 30 minute. Renal scintigraphy was also performed in follow-up of 37 post-nephrectomy kidney donors. Results 6 of 72 (8.3%) living related donors were excluded from nephrectomy due to reduced GFR of either total or individual kidney. One of 6 excluded donors had one non-functional kidney. No donors have shown urinary tract obstruction. In 66 kidney donors who were indicated nephrectomy, pre-nephrectomy mean total GFR, calculated by Gates method, was 108 mi/minute that was significantly higher than GFR result of 94 mi/minute by Cockcroft and Gault prediction equation (p 0.05). These results are not significant, indicative of functional compensation occuring after unilateral nephrectomy. Conclusion: Tc-99m DTPA dynamic renal scintigraphy using Gates protocol with extended acquisition time is a valuable simple radionuclide technique which is able to assess total and individual renal function and urinary outflow tract. This technique should be used as an integral part of the pre-operative evaluation contributing to the choice of nephrectomy side in potential kidney donors and as follow-up of post-operative remaining kidney. (authors)

  5. Synthesis, crystal structure and redox properties of dihydropyrazole-bridged ferrocene-based derivatives

    Science.gov (United States)

    Li, Heng-Dong; Ma, Zai-He; Yang, Kun; Xie, Li-Li; Yuan, Yao-Feng

    2012-09-01

    Dihydropyrazole-bridged ferrocene-based derivatives were prepared by corresponding chalcones with hydrazine hydrate, then acylation with 3-(ethoxycarbonyl)propionyl chloride directly in high yields and purity. All of these compounds were characterized by MS, IR, 1H NMR, 13C NMR and elemental analysis. The relationship between the structure and redox properties was investigated based on the results of single crystal X-ray structure determinations and cyclic voltammetry. The mechanism of the electron transfer for representative compound 4b was verified by density functional theory (DFT) calculations.

  6. Carbon-Based Functional Materials Derived from Waste for Water Remediation and Energy Storage.

    Science.gov (United States)

    Ma, Qinglang; Yu, Yifu; Sindoro, Melinda; Fane, Anthony G; Wang, Rong; Zhang, Hua

    2017-04-01

    Carbon-based functional materials hold the key for solving global challenges in the areas of water scarcity and the energy crisis. Although carbon nanotubes (CNTs) and graphene have shown promising results in various fields of application, their high preparation cost and low production yield still dramatically hinder their wide practical applications. Therefore, there is an urgent call for preparing carbon-based functional materials from low-cost, abundant, and sustainable sources. Recent innovative strategies have been developed to convert various waste materials into valuable carbon-based functional materials. These waste-derived carbon-based functional materials have shown great potential in many applications, especially as sorbents for water remediation and electrodes for energy storage. Here, the research progress in the preparation of waste-derived carbon-based functional materials is summarized, along with their applications in water remediation and energy storage; challenges and future research directions in this emerging research field are also discussed. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Deriving airborne laser scanning based computational canopy volume for forest biomass and allometry studies

    Science.gov (United States)

    Vauhkonen, Jari; Næsset, Erik; Gobakken, Terje

    2014-10-01

    A computational canopy volume (CCV) based on airborne laser scanning (ALS) data is proposed to improve predictions of forest biomass and other related attributes like stem volume and basal area. An approach to derive the CCV based on computational geometry, topological connectivity and numerical optimization was tested with sparse-density, plot-level ALS data acquired from 40 field sample plots of 500-1000 m2 located in a boreal forest in Norway. The CCV had a high correspondence with the biomass attributes considered when derived from optimized filtrations, i.e. ordered sets of simplices belonging to the triangulations based on the point data. Coefficients of determination (R2) between the CCV and total above-ground biomass, canopy biomass, stem volume, and basal area were 0.88-0.89, 0.89, 0.83-0.97, and 0.88-0.92, respectively, depending on the applied filtration. The magnitude of the required filtration was found to increase according to an increasing basal area, which indicated a possibility to predict this magnitude by means of ALS-based height and density metrics. A simple prediction model provided CCVs which had R2 of 0.77-0.90 with the aforementioned forest attributes. The derived CCVs always produced complementary information and were mainly able to improve the predictions of forest biomass relative to models based on the height and density metrics, yet only by 0-1.9 percentage points in terms of relative root mean squared error. Possibilities to improve the CCVs by a further analysis of topological persistence are discussed.

  8. Analytical derivation: An epistemic game for solving mathematically based physics problems

    Directory of Open Access Journals (Sweden)

    Rabindra R. Bajracharya

    2016-03-01

    Full Text Available Problem solving, which often involves multiple steps, is an integral part of physics learning and teaching. Using the perspective of the epistemic game, we documented a specific game that is commonly pursued by students while solving mathematically based physics problems: the analytical derivation game. This game involves deriving an equation through symbolic manipulations and routine mathematical operations, usually without any physical interpretation of the processes. This game often creates cognitive obstacles in students, preventing them from using alternative resources or better approaches during problem solving. We conducted hour-long, semi-structured, individual interviews with fourteen introductory physics students. Students were asked to solve four “pseudophysics” problems containing algebraic and graphical representations. The problems required the application of the fundamental theorem of calculus (FTC, which is one of the most frequently used mathematical concepts in physics problem solving. We show that the analytical derivation game is necessary, but not sufficient, to solve mathematically based physics problems, specifically those involving graphical representations.

  9. Bio-Based Production of Dimethyl Itaconate From Rice Wine Waste-Derived Itaconic Acid.

    Science.gov (United States)

    Joo, Young-Chul; You, Seung Kyou; Shin, Sang Kyu; Ko, Young Jin; Jung, Ki Ho; Sim, Sang A; Han, Sung Ok

    2017-11-01

    Dimethyl itaconate is an important raw material for copolymerization, but it is not synthesized from itaconic acid by organisms. Moreover, Corynebacterium glutamicum is used as an important industrial host for the production of organic acids, but it does not metabolize itaconic acid. Therefore, the biosynthetic route toward dimethyl itaconate from itaconic acid is highly needed. In this study, a biological procedure for dimethyl itaconate production is developed from rice wine waste-derived itaconic acid using the engineered C. glutamicum strain. The first step is to investigate the effect of the co-overexpression of the codon-optimized cis-aconitic acid decarboxylase (CadA*) and a transcriptional regulator of genes involved in acetic acid metabolism (RamA) on itaconic acid production. The second step is to convert itaconic acid into dimethyl itaconate by lipase-catalyzed esterification. The CadA* and RamA-overexpressing CG4 strain increases the itaconic acid concentration under N-starvation with glucose and acetic acid compared with the concentration produced in the base mCGXII medium with glucose. Furthermore, the rice wine waste-derived itaconic acid is successfully converted into dimethyl itaconate using lipase from Rhizomucor miehei and a methanol substrate. This study is the first trial for bio-based production of dimethyl itaconate from rice wine waste-derived itaconic acid. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Synthesis, characterisation and evaluation of N-mannich bases of 2-substituted Benzimidazole derivatives

    Science.gov (United States)

    Vinoth Kumar, Sekar; Subramanian, Mohan Raj; Chinnaiyan, Santhosh Kumar

    2013-01-01

    Rationale Benzimidazoles and its derivatives represent one of the mainly biological active classes of literature. Aim In this present study aimed to synthesize N-mannich bases derivatives compounds bearing of 2-substituted benzimidazole moiety, in order to investigate their possible biological activity. Method Benzimidazole compounds were prepared from the condensation reaction between ortho phenylene diamine and various acids. Mannich base of newly synthesized Benzimidazole derivatives were synthesized from 2-substituted Benzimidazoles by reacting with secondary amines. The purity of the compounds was ascertained by melting point (m.p) and thin layer chromatography (TLC). Structures of the synthesized compounds were elucidated by spectral data. Antimicrobial assay was performed by microbroth dilution method. Bacterial genomic DNA cleavage was assessed by Agarose gel electrophoresis. Toxicity of the most effective compounds was studied by Brine-shrimp lethality assay. Result Among the synthesized compounds, compound 5E (a) and (b) was establish to be the most potent against all tested microorganisms. This two compounds exhibited complete bacterial DNA cleavage and non-toxic. Conclusion These results suggest that it an interesting compound compared to the current therapeutic agents and are considered to investigate further for the same. PMID:24563595

  11. Development of derived limits for radiological protection against ionizing radiation based on ICRP-60 recommendations

    International Nuclear Information System (INIS)

    Jang, S. Y.; Lee, B. S.

    1999-01-01

    Derived limits such as the Annual Limit on Intake (ALI), Derived Air Concentration (DAC) and Effluent Concentration Limit (ECL) for radiological protection against ionizing radiation based on ICRP-60 recommendations were calculated using dose limits and committed effective dose coefficients of the basic Safety Standards of IAEA (i.e. safety series 115; BSS-96). Derived limits regarding occupational exposure were derived using methodologies of ICRP-61 and dose limit stated in ICRP -60. ECL in air and water for the control of radioactive discharge into the environment were derived using methodologies of 10 CFR part 20 and dose limit stated in ICRP-60. In order to analyze the impact of implementing derived limits on nuclear facilities, the derived values in this study were compared with those prescribed in 10 CFR part 20 as well as the Maximum Permissible Concentrations (MPC) of Notice No. 98-12 of the Ministry of Science and Technology (MOST). According to the comparison results, ECLs in air and water for the control of radioactive discharge into the environment in this study are shown to have lower values (i.e. more conservative), for most part, than those in Notice No. 98-12. These differences are due to the reduction of dose limit, adoption of a weighting factor for age-dependency in dose coefficients, and application of new respiratory tract model and bio-kinetics model. Especially, for uranium elements (i.e., 235 U, 238 U, etc.), which are governing ones in the nuclear fuel industries, ECLs in water are approximately a magnitude in the order of two lower than those in Notice No. 98-12. These are attributable to the adoption of a weighting factor for age-dependency in dose coefficients, newly recommended dose coefficients for ingestion pathway, and reduction of dose limit. It was found out that the differences in ECLs in water for uranium elements originated mostly from ingestion dose coefficients recommended by BSS-96. (author). 6 refs., 2 tabs., 5 figs

  12. Pre-conceptual-schema-based patterns for deriving key performance indicators from strategic objectives

    Directory of Open Access Journals (Sweden)

    Carlos Mario Zapata Jaramillo

    2017-05-01

    Full Text Available Performance measurement is crucial for achieving business success. Moreover, such success is also related to the fulfillment of the organizational strategic objectives. Hence, an adequate determination of relevant performance indicators—or key performance indicators (KPIs—and their relationships to organizational objectives is needed. Even though several approaches for treating KPIs and objective-KPI relationships have been proposed, they exhibit some drawbacks associated with the lack of reusability and traceability. We attempt to fill this gap by proposing a set of patterns based on pre-conceptual schemas for supporting the systematic derivation of KPIs and their relationships to organizational objectives. In this way, the proposed patterns guarantee a reusable and traceable derivation process of a set of candidate KPIs from organizational strategic objectives. Lastly, we provide a lab study in order to illustrate the usefulness of this proposal.

  13. Advanced nanocarriers based on heparin and its derivatives for cancer management.

    Science.gov (United States)

    Yang, Xiaoye; Du, Hongliang; Liu, Jiyong; Zhai, Guangxi

    2015-02-09

    To obtain a satisfying anticancer effect, rationally designed nanocarriers are intensively studied. In this field, heparin and its derivatives have been widely attempted recently as potential component of nanocarriers due to their unique biological and physiochemical features, especially the anticancer activity. This review focuses on state-of-the-art nanocarriers with heparin/heparin derivatives as backbone or coating material. At the beginning, the unique advantages of heparin used in cancer nanotechnology are discussed. After that, different strategies of heparin chemical modification are reviewed, laying the foundation of developing various nanocarriers. Then a systematic summary of diverse nanoparticles with heparin as component is exhibited, involving heparin-drug conjugate, polymeric nanoparticles, nanogels, polyelectrolyte complex nanoparticles, and heparin-coated organic and inorganic nanoparticles. The application of these nanoparticles in various novel cancer therapy (containing targeted therapy, magnetic therapy, photodynamic therapy, and gene therapy) will be highlighted. Finally, future challenges and opportunities of heparin-based biomaterials in cancer nanotechnology are discussed.

  14. Solution Processable Organic Solar Cell Based on Bulk Heterojunction Utilizing Phthalocyanine Derivative

    Science.gov (United States)

    Hori, Tetsuro; Miyake, Yasuo; Yamasaki, Naoyuki; Yoshida, Hiroyuki; Fujii, Akihiko; Shimizu, Yo; Ozaki, Masanori

    2010-10-01

    Organic thin-film solar cells based on a bulk heterojunction utilizing the phthalocyanine derivative 1,4,8,11,15,18,22,25-octahexylphthalocyanine (C6PcH2) have been studied. C6PcH2 is soluble in common organic solvents such as chloroform, and the blend uniform thin film with the fullerene derivative 1-(3-methoxy-carbonyl)-propyl-1-1-phenyl-(6,6)C61 (PCBM) could be fabricated by a spin-coating method. Solar cells with an indium-tin-oxide/polymer hole transport layer/C6PcH2:PCBM/Al structure, the active layer of which was prepared by a wet process using a low-weighted molecular system, have demonstrated a high external quantum efficiency of more than 70% in the Q-band absorption region of C6PcH2 and a high energy conversion efficiency of 3.1%.

  15. Fingerprint Image Enhancement Based on Second Directional Derivative of the Digital Image

    Directory of Open Access Journals (Sweden)

    Onnia Vesa

    2002-01-01

    Full Text Available This paper presents a novel approach of fingerprint image enhancement that relies on detecting the fingerprint ridges as image regions where the second directional derivative of the digital image is positive. A facet model is used in order to approximate the derivatives at each image pixel based on the intensity values of pixels located in a certain neighborhood. We note that the size of this neighborhood has a critical role in achieving accurate enhancement results. Using neighborhoods of various sizes, the proposed algorithm determines several candidate binary representations of the input fingerprint pattern. Subsequently, an output binary ridge-map image is created by selecting image zones, from the available binary image candidates, according to a MAP selection rule. Two public domain collections of fingerprint images are used in order to objectively assess the performance of the proposed fingerprint image enhancement approach.

  16. Luminescent liquid crystalline materials based on palladium(II) imine derivatives containing the 2-phenylpyridine core.

    Science.gov (United States)

    Micutz, Marin; Iliş, Monica; Staicu, Teodora; Dumitraşcu, Florea; Pasuk, Iuliana; Molard, Yann; Roisnel, Thierry; Cîrcu, Viorel

    2014-01-21

    In this work we report our studies concerning the synthesis and characterisation of a series of imine derivatives that incorporate the 2-phenylpyridine (2-ppy) core. These derivatives were used in the cyclometalating reactions of platinum(II) or palladium(II) in order to prepare several complexes with liquid crystalline properties. Depending on the starting materials used as well as the solvents employed, different metal complexes were obtained, some of them showing both liquid crystalline behaviour and luminescence properties at room temperature. It was found that, even if there are two competing coordination sites, the cyclometalation process takes place always at the 2-ppy core with (for Pt) or without (for Pd) the imine bond cleavage. We successfully showed that it is possible to prepare emissive room temperature liquid crystalline materials based on double cyclopalladated heteroleptic complexes by varying the volume fraction of the long flexible alkyl tails on the ancillary benzoylthiourea (BTU) ligands.

  17. Aspects of inhaled DTPA toxicity in the rat, hamster and beagle dog and treatment effectiveness for excorporation of Pu from the rat

    International Nuclear Information System (INIS)

    Smith, V.H.; Ballou, J.E.; Lund, J.E.; Dagle, G.E.; Ragan, H.A.; Busch, R.H.; Hackett, P.L.; Willard, D.W.

    1975-01-01

    After inhaling 1 to 4 HD (human dose equivalents, i.e., 1 g calcium trisodium N,N-bis (2-bis(carboxymethyl)amino) ethyl) glycinate/70 kg body weight) of Ca-DTPA rats and hamsters developed a transitory vesicular emphysema. This was not found in animals sacrificed later than 3 weeks after the last exposure. Dogs were anesthetised and administered Ca-DTPA aerosols via an intratracheal catheter for 30 min/day for 5 days. The average dose/exposure was 4 HD. One week following the last exposure, 3/4 treated dogs and 0/2 dogs exposed to saline aerosols showed enlargement and submucosal lymphoid follicles in the pyloric region of the stomach; this was not present in dogs sacrificed at 4, 8 or 18 weeks postexposure. Epithelial atypia in the alveolar lining was noted in 5/16 dogs inhaling Ca-DTPA and in 1/8 dogs exposed to saline aerosols, and may or may not be treatment-related. Rats receiving 1.2 μCi 238 Pu(NO 3 ) 4 intramuscularly were treated promptly with 1.2 HD inhaled or intraperitoneally injected Ca-DTPA. The two methods of Ca-DTPA administration gave statistically identical Pu excorporation. Similar treatments initiated 8 months following the Pu injection also showed no effect of administration route. These experiments and implications for the safety and efficacy of inhaled Ca-DTPA as treatment for transuranic incorporations in man are discussed

  18. A systematic study on the utility of CHX-A''-DTPA-NCS and NOTA-NCS as bifunctional chelators for177Lu radiopharmaceuticals.

    Science.gov (United States)

    Pandey, Usha; Gamre, Naresh; Lohar, Sharad Pandurang; Dash, Ashutosh

    2017-09-01

    This paper describes the evaluation of [(R)-2-Amino-3-(4-isothiocyanatophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-pentaacetic acid (CHX-A''-DTPA-NCS) and 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA-NCS) as bifunctional chelators for 177 Lu. While 177 Lu-CHX-A''-DTPA-NCS could be obtained in high yields at equimolar ratios of lutetium to CHX-A''-DTPA-NCS, >95% yield of 177 Lu-NOTA-NCS could be achieved at 1:2M ratio of lutetium to NOTA-NCS. Trace metals reduced the yields of 177 Lu-NOTA-NCS significantly as compared to 177 Lu-CHX-A''-DTPA-NCS. In vitro stability of 177 Lu-CHX-A''-DTPA-NCS was also superior to 177 Lu-NOTA-NCS. It could be concluded from this study that among the two chelators evaluated, CHX-A''-DTPA-NCS is more appropriate for preparation of 177 Lu radiopharmaceuticals. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Early Seizure Detection by Applying Frequency-Based Algorithm Derived from the Principal Component Analysis.

    Science.gov (United States)

    Lee, Jiseon; Park, Junhee; Yang, Sejung; Kim, Hani; Choi, Yun Seo; Kim, Hyeon Jin; Lee, Hyang Woon; Lee, Byung-Uk

    2017-01-01

    The use of automatic electrical stimulation in response to early seizure detection has been introduced as a new treatment for intractable epilepsy. For the effective application of this method as a successful treatment, improving the accuracy of the early seizure detection is crucial. In this paper, we proposed the application of a frequency-based algorithm derived from principal component analysis (PCA), and demonstrated improved efficacy for early seizure detection in a pilocarpine-induced epilepsy rat model. A total of 100 ictal electroencephalographs (EEG) during spontaneous recurrent seizures from 11 epileptic rats were finally included for the analysis. PCA was applied to the covariance matrix of a conventional EEG frequency band signal. Two PCA results were compared: one from the initial segment of seizures (5 sec of seizure onset) and the other from the whole segment of seizures. In order to compare the accuracy, we obtained the specific threshold satisfying the target performance from the training set, and compared the False Positive (FP), False Negative (FN), and Latency (Lat) of the PCA based feature derived from the initial segment of seizures to the other six features in the testing set. The PCA based feature derived from the initial segment of seizures performed significantly better than other features with a 1.40% FP, zero FN, and 0.14 s Lat. These results demonstrated that the proposed frequency-based feature from PCA that captures the characteristics of the initial phase of seizure was effective for early detection of seizures. Experiments with rat ictal EEGs showed an improved early seizure detection rate with PCA applied to the covariance of the initial 5 s segment of visual seizure onset instead of using the whole seizure segment or other conventional frequency bands.

  20. Assessment of Renal Functional Status with the ''Kidney to Liver Ratio'' - A comparative study with Tc-99m DTPA Renography

    International Nuclear Information System (INIS)

    Hussain, R; Haque, J.A.; Rahman, M.; Karim, M.A.

    2001-01-01

    For the assessment of renal functional status, DTPA renography is widely used. Split function provides excellent information, but it has certain shortcomings especially in bilateral renal disease or in solitary kidney. This study demonstrates the importance of kidney to liver ratio as a functional parameter. In 65 patients, a total of 123 kidney were studied. Renographic studies were done after a bolus of Tc-99m DTPA. The kidney to liver ratios was calculated at 3 minutes (K3/L3). The ratios and renography curve patterns correlated well in 101 (82%) kidneys, both normal in 42 and both abnormal in 59 kidneys. Only 22 (18%) kidneys had discrepancies and among them 12 showed abnormal ratios but having normal renogram curves. The findings display the usefulness of K3/L3 ratio. The authors advocate that it is a good parameter for renal studies. (author) 9 refs., 3 tabs

  1. Emergency treatment of pulmonary contaminations by transuranium elements. A new galenic form of Na3CaDTPA

    International Nuclear Information System (INIS)

    Tymen, H.; Curet, P.M.; Schoulz, D.; Caire-Maurisier, A.M.; Chevrier, F.

    2000-01-01

    The emergency treatment of pulmonary contamination by plutonium and transuranium elements needs the early use of a chelator, the Na 3 CaDTPA under mono-calcic tri-sodic form. The local administration of the active principle is carried out by an appliance. the Spinhaler, which delivers the active principle under micronized form without any propelled gas. The French Military Health Service is the manufacturer which produces this treatment and has studied a modification of the galenic form of Na 3 CaDTPA to improve the intrapulmonary distribution. This treatment, without any secondary effect, is proposed even for a presumed pulmonary contamination. Its easy use allows an early administration for a large number of people supposed to be contaminated. However, it cannot take the place of the other forms of treatment, especially intravenous, which needs a medical prescription in case of an established contamination. (author)

  2. MRT of experimental liver abscesses - comparison of a new blood pool contrast agent with gadolinium-DTPA

    International Nuclear Information System (INIS)

    Dick, A.; Adam, G.; Spuentrup, E.; Prescher, A.; Muehler, A.; Guenther, R.W.

    1996-01-01

    Purpose: In an experimental pyogenic liver abscess model, the signal intensities were compared intraindividually and interindividually after the application of a new blood pool contrast agent, 24-gadolinium-DTPA (diethylenetriamine-pentaacetic acid) cascade polymer, and after the application of gadopentetate dimeglumine. Methods: In 20 rabbits with experimentally induced liver abscesses, the relative signal intensities of the liver, abscess centre, abscess wall and portal vein were assessed before and between 30 seconds and 60 minutes after injection of a 25 μmol/kg dose of gadolinium polymer and of 100 μmol/kg of gadolinium-DTPA, respectively. Measurements were performed at 1.5 Tesla, using a head coil and a Flash-2-D sequence. Results: The interindividual comparison (unpaired T-test, p [de

  3. The influence of age and plasma glucagon on renal clearance of sup(99m)Tc-DTPA (Sn)

    International Nuclear Information System (INIS)

    Sampson, W.F.D.; Macleod, M.A.; Houston, A.S.

    1980-01-01

    Using an external arm counting technique and sup(99m)Tc-DTPA(Sn), as previously described (Macleod, Sampson and Houston, 1977), the glomerular filtration rate (GFR) of 120 subjects with normal renal function was measured and found to correlate significantly with age (r = 0.91). Using the same technique in the investigation of 260 patients with a variety of diagnoses but who had normal renal function (GFR greater than 86 mls/min), 42 (16%) were found to clear the sup(99m)Tc-DTPA significantly faster. Twelve of these were subsequently found to be diabetic and to have significantly raised plasma glucagon levels. The remaining 30 also had significantly high plasma glucagon levels. (orig.) [de

  4. In vivo quantification of the unidirectional influx constant for Gd-DTPA diffusion across the myocardial capillaries with MR imaging

    DEFF Research Database (Denmark)

    Larsson, H B; Stubgaard, M; Søndergaard, Lise

    1994-01-01

    ) and the perfusion (F) by the equation Ki = E.F.Ki was obtained by using the longitudinal relaxation rate (R1) as a measure of the myocardial concentration of Gd-DTPA in the mathematical model for transcapillary transport across capillary membranes. Myocardial enhancement after Gd-DTPA injection was followed...... by using inversion-recovery Turbo-FLASH (fast low-angle shot) images obtained in real time. The results were comparable to those obtained from studies with positron emission tomography in humans and invasive studies in animals. A method for obtaining the input function noninvasively is also presented....... Comparison with direct arterial blood sampling showed that the noninvasive input function may be even more accurate with regard to timing and curve shape than the invasive input function. The procedure may therefore prove useful in clinical studies....

  5. Hot test of a TALSPEAK procedure for separation of actinides and lanthanides using recirculating DTPA-lactic acid solution

    International Nuclear Information System (INIS)

    Persson, G.; Svantesson, I.; Wingefors, S.; Liljenzin, J.O.

    1984-01-01

    Results are reported from a hot test of a TALSPEAK type process for separation of higher actinides (Am, Cm) from lanthanides. Actinides and lanthanides are extracted by 1 M HDEHP and separated by selective strip of the actinides, using a mixture of DTPA and lactic acid (reversed TALSPEAK process). In order to minimize the generation of secondary waste, a procedure using recirculating DTPA-Lactic acid solution has been developed. A separation factor between Am and Eu of 132 was achieved. In regard to separations of Am and Cm from commercial HLLW (high level liquid wastes), the factor corresponds to 1.5% of the lanthanide group remaining with the actinides. The loss of Am was about 0.2%. 9 figures, 3 tables

  6. Cerebrospinal fluid flow abnormalities in patients with neoplastic meningitis. An evaluation using 111In-DTPA ventriculography

    International Nuclear Information System (INIS)

    Grossman, S.A.; Trump, D.L.; Chen, D.C.; Thompson, G.; Camargo, E.E.

    1982-01-01

    Cerebrospinal fluid flow dynamics were evaluated by 111 In-diethylenetriamine pentaacetic acid ( 111 In-DTPA) ventriculography in 27 patients with neoplastic meningitis. Nineteen patients (70 percent) had evidence of cerebrospinal fluid flow disturbances. These occurred as ventricular outlet obstructions, abnormalities of flow in the spinal canal, or flow distrubances over the cortical convexities. Tumor histology, physical examination, cerebrospinal fluid analysis, myelograms, and computerized axial tomographic scans were not sufficient to predict cerebrospinal fluid flow patterns. These data indicate that cerebrospinal fluid flow abnormalities are common in patients with neoplastic meningitis and that 111 In-DTPA cerebrospinal fluid flow imaging is useful in characterizing these abnormalities. This technique provides insight into the distribution of intraventricularly administered chemotherapy and may provide explanations for treatment failure and drug-induced neurotoxicity in patients with neoplastic meningitis

  7. Research on the influencing factors of measuring glomerular filtration rate through 99Tcm-DTPA renal dynamic imaging

    International Nuclear Information System (INIS)

    Huang Jianmin; Tang Zidu; Pan Liping; Liu Xiaomei; Xie Peng; Gao Jianqing

    2011-01-01

    Glomerular filtration rate (GFR) is an important criterion to estimate renal function. The most common way to measure GFR clinically is 99 Tc m -DTPA Renal Dynamic Imaging. However, the result may be influenced by many factors such as plasma protein binding, delineation of kidney and background region of interest, kidney depth, age and renal function and preparation of patient, nurse's operative technique, etc. The article analyzed each factor above respectively for clinical reference. (authors)

  8. Pulmonary clearance of {sup 99m}Tc-DTPA in experimental surfactant dysfunction treated with surfactant installation

    Energy Technology Data Exchange (ETDEWEB)

    Nilsson, K.; John, J.; Lachmann, B.; Robertson, B.; Wollmer, P.

    1997-02-01

    Background: Breakdown of the alveolo-capillary barrier is a characteristic feature of respiratory distress syndrome. Restoration of alveolo-capillary barrier function may be an important aspect of surfactant replacement therapy. We examined the effect of surfactant installation on alveolo-capillary barrier function in an experimental model of surfactant dysfunction by measuring pulmonary clearance of {sup 99m}Tc-DTPA. Methods: Nineteen rabbits were tracheotomized and mechanically ventilated. Surfactant dysfunction was induced by administration of a synthetic detergent in aerosol form. Detergent was given to 13 rabbits; seven rabbits were then treated with installation of natural surfactant, whereas six rabbits received saline. Six rabbits were used as untreated controls. An aerosol of {sup 99m}Tc-DTPA was administered to all animals and the pulmonary clearance was measured with a gamma camera. Results: {sup 99m}Tc-DTPA cleared from the lungs with a half-life of 71{+-}22 min in the control animals, 21.4{+-}7.4 min in the surfactant-treated animals and 5.8{+-}1.5 min in the saline-treated animals. The difference in half-life between groups was highly significant (P<0.001). There was no change in arterial oxygenation or compliance in controls or in animals treated with saline. In animals treated with surfactant, a small transient reduction in arterial oxygen tension and a more long-standing reduction in compliance were observed. Conclusion: Surfactant treatment thus significantly attenuated the effect of detergent treatment but did not restore alveolo-capillary transfer of {sup 99m}Tc-DTPA to normal. (AU) 26 refs.

  9. Intracoronary delivery of Gd-DTPA and Gadophrin-2 for determination of myocardial viability with MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Ni, Y.; Bosmans, H.; Miao, Y.; Bogaert, J.; Dymarkowski, S.; Yu, J.; Baert, A.L.; Marchal, G. [Dept. of Radiology, University Hospitals, Catholic University Leuven (Belgium); Pislaru, C.; Pislaru, S.; Werf, F. van de [Dept. of Cardiology, University Hospitals, Catholic University Leuven (Belgium); Semmler, W. [Inst. fuer Diagnostikforschung GmbH, Berlin (Germany)

    2001-05-01

    The aim of this study was to compare intracoronary (i. c.) administration of Gadophrin-2, a necrosis-avid contrast agent (NACA), and nonspecific agent Gd-DTPA for determination of myocardial viability (MV) in acute myocardial infarction (AMI) with MRI. Reperfused AMI was induced in 12 dogs by transcatheter balloon occlusion of coronary artery. In 6 dogs each, Gd-DTPA at 0.1 mmol/kg or Gadophrin-2 at 0.005 mmol/kg was administered into coronary artery by fast bolus (n = 3) or slow infusion (n = 3). Serial ECG-triggered cardiac MRI of T1-weighted segmented turbo fast low-angle shot (FLASH) sequence was conducted and compared with triphenyltetrazolium chloride (TTC) histochemical staining. The contrast ratio and infarct size were quantified and analysed statistically. No cardiovascular side effects were found with local delivery of both agents. After i. c. administration, Gadophrin-2 induced a strong (CR {>=} 1.78) and persistent ({>=} 10 h) contrast enhancement of infarcted region. The infarct size defined with Gadophrin-2 was almost identical to that with TTC staining throughout the postcontrast period. With a dose 20 times higher, Gd-DTPA also strongly enhanced infarct-to-normal contrast; however, the enhancement diminished with time, i. e. from early strong to later faint enhancement and eventual loss of contrast. The delineated infarct size was also unstable, i. e. from early overestimation to later underestimation and eventual disappearance of the enhanced infarct. In combination with PTCA procedure, i. c. administration of MRI contrast agents may prove useful for post-procedure verification of diagnosis. The NACA-enhanced MRI may serve as an in vivo surrogate of postmortem histochemical staining for determination of MV. Although applicable in clinical setting, cardiac MRI with nonspecific Gd-DTPA is less reliable and should be performed within less than 1 h after contrast. (orig.)

  10. The fate of EDTA and DTPA in aquatic environments receiving waste water from two pulp and paper mills

    Energy Technology Data Exchange (ETDEWEB)

    Remberger, M.; Svenson, Anders

    1997-10-01

    To evaluate the fate of the complexing agents in receiving waters, two basic questions have been addressed: (i) are EDTA and DTPA found in the aquatic environment after discharge into receiving waters and (ii) are they photolytically converted. Two mills, one pulp mill localized at a fresh water lake and one pulp and paper mill at a brackish water were investigated, both mills using bleaching technologies with EDTA and DTPA as complexing agents. Samples were collected at the discharge point and along a gradient in the receiving waters at two occasions: summer at solstice and winter with low light intensity. Samples were taken from surface water, an intermediate depth, and bottom water. A new analytical method was applied, which made it possible to quantify the analytes at sub-{mu}g/l level. The complexing agents EDTA and DTPA and their primary degradation products were detected in the effluent and the receiving waters in the vicinity of the mills. DTPA and the degradation products could be detected a few kilometers from the effluent point while EDTA could be detected in more remote locations at fairly constant concentrations. The absorption of light in the sun spectrum in the water columns of the receiving waters was studied at different localities and during summer and winter conditions. The theoretical photochemical half-life of the ferric complex of EDTA in the surface layer of a central Swedish lake was confirmed. Analysis of EDTA in samples of receiving waters after photolytic treatment showed however, that a large portion of the complexing agent was unaffected by the treatment, indicating that most of the EDTA was complexed with other metals. EDTA in brackish water samples was unaffected by the photolytic treatment upon addition of excess ferric ions, except in winter close to the discharge point. The ease by which the ferric complexes are photochemically converted in ideal conditions seems to be hampered in receiving waters. 42 refs, 16 figs, 2 tabs

  11. Cerebral vasodilatory capacity mapping using technetium-99m-DTPA-HSA SPECT and acetazolamide in moyamoya disease.

    Science.gov (United States)

    Inoue, Y; Momose, T; Machida, K; Honda, N; Tsutsumi, K

    1993-11-01

    A cerebral vasodilatory capacity map, consisting of a 99mTc-DTPA-HSA SPECT image obtained after acetazolamide injection minus the baseline image, was produced in a patient with moyamoya disease. The map demonstrated diminished capacity in the posterior region of the right cerebral hemisphere. Subsequently, cerebral infarction occurred in the corresponding area. This observation suggests that regions of low vasodilatory capacity identified by cerebral vasodilatory capacity mapping may be at high risk of ischemic stroke.

  12. Cerebral and meningeal manifestations of AIDS: comparison of plain T2-weighted images and Gd-DTPA enhanced T1-weighted images in 105 patients; Zerebrale und meningeale Manifestationen des AIDS: Vergleich von nativer T2-gewichteter und Gd-DTPA unterstuetzter T1-gewichteter MRT (105 Patienten)

    Energy Technology Data Exchange (ETDEWEB)

    Jochens, R. [Strahlenklinik und Poliklinik, Universitaetsklinikum Rudolf Virchow, Standort Wedding, Freie Univ. Berlin (Germany); Henkes, H. [Klinik fuer Radiologische Diagnostik und Neuroradiologie, Alfried Krupp Krankenhaus, Essen (Germany); Steinkamp, H.J. [Strahlenklinik und Poliklinik, Universitaetsklinikum Rudolf Virchow, Standort Wedding, Freie Univ. Berlin (Germany); Terstegge, K. [Strahlenklinik und Poliklinik, Universitaetsklinikum Rudolf Virchow, Standort Wedding, Freie Univ. Berlin (Germany); Hosten, N. [Strahlenklinik und Poliklinik, Universitaetsklinikum Rudolf Virchow, Standort Wedding, Freie Univ. Berlin (Germany); Ruf, B. [II. Medizinische Klinik, Universitaetsklinikum Rudolf Virchow, Freie Univ. Berlin, Standort Wedding (Germany); Schoerner, W. [Inst. fuer Roentgendiagnostik und Nuklearmedizin, Staedtisches Klinikum, Braunschweig (Germany)

    1994-12-31

    The purpose of the present study was to evaluate the potential of T1-weighted Gd-DTPA enhanced MR imaging in the diagnosis of cerebral manifestations of AIDS. 105 patients with AIDS were imaged with plain T2-weighted images as well as with Gd-DTPA enhanced T1-weighted pulse sequences. Our study revealed comparable sensitivities in the detection of morphological changes as shown on plain T2-weighted images and Gd-DTPA enhanced T1-weighted images in 55% of patients (normal and pathologic findings). Plain T2-weighted images were superior in 28.5% and provided significantly better results in 8.5% of patients. Gd-DTPA enhanced T1-weighted images were superior in only 5% cases and revealed significantly better results in 3%. T2-weighted plain images were superior in approximately 40% of patients concerning detection of morphologic changes. In almost 10% of patients with parechymal and meningeal lesions, Gd-DTPA enhanced T1-weighted images, however, were superior or even significantly better compared to T2-weighted plain images. The detection of morphologic changes in MR imaging can be further increased with Gd-DTPA. With regard to differential diagnosis and diesease activity, plain T2-weighted images and Gd-DTPA enhanced T1-weighted images revealed comparable results in 42% of patients (normal and pathologic findings). T2-weighted plain images were superior in 2% of cases whereas Gd-DTPA enhanced T1-weighted images were superior in as much as 56% of patient. MR imaging enhanced with Gd-DTPA yielded additional information on disease activity in 73% of patients with pathologic findings in the cerebral parechyma and the meninges. The surplus of information also refers to the etiology of cerebral pathology and differential diagnosis. Because of the frequency of cerebral manifestations in AIDS, early diagnosis for initiation of therapy and follow-up studies to monitor therapy are crucial. (orig./MG) [Deutsch] Den Stellenwert der T1-gewichteten Gd-DTPA unterstuetzten MRT im

  13. Derivative Trade Optimizing Model Utilizing GP Based on Behavioral Finance Theory

    Science.gov (United States)

    Matsumura, Koki; Kawamoto, Masaru

    This paper proposed a new technique which makes the strategy trees for the derivative (option) trading investment decision based on the behavioral finance theory and optimizes it using evolutionary computation, in order to achieve high profitability. The strategy tree uses a technical analysis based on a statistical, experienced technique for the investment decision. The trading model is represented by various technical indexes, and the strategy tree is optimized by the genetic programming(GP) which is one of the evolutionary computations. Moreover, this paper proposed a method using the prospect theory based on the behavioral finance theory to set psychological bias for profit and deficit and attempted to select the appropriate strike price of option for the higher investment efficiency. As a result, this technique produced a good result and found the effectiveness of this trading model by the optimized dealings strategy.

  14. Myocardial tissue characterization in hypertrophic cardiomyopathy. Comparison between Gd-DTPA enhanced MR signal intensity ratio and myocardial biopsy

    Energy Technology Data Exchange (ETDEWEB)

    Tsukihashi, Hironori; Shimada, Toshio; Ishibashi, Yutaka [Shimane Medical Univ., Izumo (Japan)] [and others

    1995-09-01

    The aim of this study is to demonstrate whether Gd-DTPA enhanced magnetic resonance imaging (Gd-EMRI) can be used to evaluate myocardial tissue characterization. We performed Gd-EMRI in 20 patients with hypertrophic cardiomyopathy (HCM) and 6 normal controls. Ventricular myocardial biopsy was performed in 7 patients. Gd-EMRI was obtained every 10 minutes from 5 to 50 minutes after intravenous Gd-DTPA (0.1 mmol/kg) injection. Signal intensity (SI) in hypertrophic region of myocardium was measured from LV short axis image. We standardized the data according to following equations. IR (intensity ratio) =SI (myocardium) /SI (skeletal muscle). SIR=IR (in time course) /IR (before Gd-DTPA injection). SIR in HCM was delayed in time course compared with that in normal controls. Interstitial fibrosis was prominent when SIR (peak) minus SIR (40min. after) /SIR (peak) was small. The delayed decay of IR in HCM was closely related to the grade of interstitial fibrosis rather than the edema of interstitial tissue or the myocardial cell diameter. We conclude that the decay analysis with Gd-EMRI is useful to evaluate myocardial tissue characterization closely related to myocardial fibrosis in comparison with cardiac histology. (author).

  15. Influence of tyramine-induced neurotoxicity on kinetics of first-pass brain TC-99m-DTPA

    International Nuclear Information System (INIS)

    Malveaux, E.; Schmidt, F.; Sarper, R.; Camp, V.; Faraj, B.A.

    1986-01-01

    Tyramine (T) induces coma in phenelzine-treated dogs. The objective of the present investigation was to examine the influence of T in MAO-inhibited dogs on the kinetics of Tc-99m-DTPA during its first passage through the brain by nuclear imaging. The study began with anesthetized dogs (n=10) in a supine position over the camera detector. Data acquisition was started simultaneously following the rapid intracarotid injection of Tc-99m-DTPA (30 mCi) and 60 0.5 second images of the brain were taken. T induced increased uptake with a concomittant impairment in the elimination of Tc-99m-DPTA from the brain of these treated animals as compared to controls. This was accompanied by an appreciable reduction in hemispheric cerebral blood flow (CBF) (56 +/- 19 vs 110 +/- 16 ml/100g/min). Increased cerebrovascular permeability of Tc-99m-DTPA and decreased CBF correlated significantly with development of intracranial hypertension and elevation in CSF catecholamines in these animals. T may have implication in the development of cerebral edema of Reye's syndrome

  16. Sequential MR images of uterus after Gd-DTPA injection; Studies of normal volunteers and uterine endometrial malignant tumors

    Energy Technology Data Exchange (ETDEWEB)

    Okada, Susumu; Kato, Tomoyasu; Yamada, Keiko; Sawano, Seishi; Yamashita, Takashi; Hirai, Yasuo; Hasumi, Katsuhiko (Japanese Foundation for Cancer Research, Tokyo (Japan). Hospital)

    1993-03-01

    To investigate the sequential changes in signal intensity (SI) of normal and abnormal uteri, T1-weighted images were taken repeatedly after the injection of Gd-diethylenetriaminepentaacetic acid (DTPA). Six volunteers and 19 patients with known uterine body malignancy (18 carcinomas, one carcinosarcoma) were examined. The results in volunteers were as follows. In the secretory phase, SI of the endometrium was stronger in the late images than in the early ones, whereas in the proliferative phase, SI was stronger in the early images. SI of the myometrium decreased rapidly and there were no differences in SI between menstrual phases. In 17 of 18 endometrial carcinomas, the tumors showed hypointensity relative to the myometrium, and the contrast between the tumor and the myometrium was better in the early images. In the remaining two cases, the tumor showed hyperintensity and the contrast was better in the late images. After the injection of Gd-DTPA, the endometrium appeared differently according to the menstrual cycle in normal volunteers, and the appearance of uterine structures and endometrial malignant tumors changed sequentially. These findings must be kept in mind when evaluating uterine diseases by Gd-DTPA enhanced MRI. (author).

  17. Comparison of peritoneal equilibration test with {sup 99m}Tc-DTPA excretion in the assessment of peritoneal permeability

    Energy Technology Data Exchange (ETDEWEB)

    Das, B.K.; Senthilnathan, M.S.; Pradhan, P.K.; Nagabhushan, S. [Department of Nuclear Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, 226014, Lucknow (India); Jeloka, T.K.; Sharma, R.K. [Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow (India)

    2004-05-01

    Assessment of peritoneal permeability is necessary for successful management of end-stage renal disease (ESRD) patients by continuous ambulatory peritoneal dialysis (CAPD). The objective of this study was to develop an alternative method of assessing the peritoneal permeability and to compare this method with the conventional method, the peritoneal equilibrium test, first described by Twardowski in 1987. Twenty patients undergoing regular CAPD were included in this study. Before starting the peritoneal dialysis, 370 MBq (10 mCi) technetium-99m diethylene triamine penta-acetic acid ({sup 99m}Tc-DTPA) was injected intravenously. A standard dose of the same quantity was kept and used later for calculations. At the end of 4 h, a dialysate fluid sample (1 ml) was collected and the total dialysis effluent fluid volume was measured. Excretion of {sup 99m}Tc-DTPA into the dialysate fluid as a percentage of the injected dose was calculated. Simultaneously, standard peritoneal equilibrium test values were recorded for comparison. Peritoneal excretion of {sup 99m}Tc-DTPA ranged from 8% to 25% of the injected dose, depending on the peritoneal membrane permeability. When the results were compared with the conventional method, a good correlation (r=0.79) was found. This innovative radionuclide technique is a simple and convenient method to assess the peritoneal membrane permeability and can be used as an alternative to the peritoneal equilibrium test, which is very cumbersome and associated with many limitations. (orig.)

  18. The effect of x rays, DTPA, and aspirin on the absorption of plutonium from the gastrointestinal tract of rats

    International Nuclear Information System (INIS)

    Sullivan, M.F.; Gorham, L.S.; Miller, B.M.

    1983-01-01

    To measure the effect of radiation on plutonium transport, rats that were exposed to 250-kVp X rays were given 238 Pu 3 days afterwards by either gavage or injection into a ligated segment of the duodenum. In a second group of experiments, rats were either injected intraduodenally with 238 Pu-DTPA or administered the chelate intravenously and the 238 Pu by gavage. In a third experiment, rats that had been gavaged with 200 or 400 mg/kg/day of aspirin for 2 days were injected intragastrically with 238 Pu nitrate. Results of the first experiment showed a dose-dependent increase in 238 Pu absorption between 800 and 1500 rad of lower-body X irradiation. Intravenous or intraduodenal injections of DTPA caused a marked increase in 238 Pu absorption but resulted in decreased plutonium deposition in the skeleton and liver. Retention of 238 Pu in the skeleton of rats given aspirin was double that of controls, but the effect on plutonium absorption was less marked than that of DTPA

  19. The clinical value of glomerular filtration rate with 99Tcm-DTPA on living kidney transplantation donor

    International Nuclear Information System (INIS)

    Xue Jianjun; Yang Aimin; Deng Huixing; Ran Hongde; Cheng Hu

    2010-01-01

    Objective: To determine the normal reference range of glomerular filtration rate (GFR) in different ages with 99 Tc m -DTPA renal dynamic imaging on living kidney transplantation donor, and to evaluate the clinical value of GFR in living kidney transplantation. Methods: 99 Tc m -DTPA renal dynamic imaging was performed in 300 patients on living kidney transplantation donor. The image was processed according to Gates' method to obtain GFR. The normal reference range of GFR was obtained in different ages and the relationship between GFR and gender, age and body mass index was also analyzed. Results: The left, right and total renal GFR of 300 living kidney transplantation donors were 49.25±10.34 ml/min. 49.27±9.69 ml/min and 98.52±19.03 ml/min, respectively. The GFR in the group of age 4 0 was higher significantly than that of age ≥50 (P 0.05). The study of logistic regression showed that the age was the only important impact factor on GFR. Conclusions: GFR obtained by 99 Tc m -DTPA is simple and reliable, which can be used to accurately assess the individual renal filterability and the urinary drainage function, This affords an useful method on screening the living relative kidney transplantation donor. (authors)

  20. Homochiral coordination polymers with helixes and metal clusters based on lactate derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Zhong-Xuan, E-mail: xuzhongxuan4201@163.com [Department of Chemistry, Zunyi Normal College, Zunyi, Guizhou 563002 (China); Ma, Yu-Lu [School of Chemical Science and Technology, Yunnan University, Kunming 650091 (China); Lv, Guo-ling [Department of Chemistry, Zunyi Normal College, Zunyi, Guizhou 563002 (China)

    2017-05-15

    Utilizing the lactic acid derivatives (R)-4-(1-carboxyethoxy)benzoic acid (denoted: (R)-H{sub 2}CBA) and (S)-4-(1-carboxyethoxy)benzoic acid (denoted: (S)-H{sub 2}CBA)as chiral linkers to self-assemble with 4, 4′-bipyridine (denoted: BIP) and Cd(II) ions, a couple of three-dimensional homochiral coordination polymers, namely [Cd{sub 3}((R)-CBA){sub 3} (BIP){sub 2}(H{sub 2}O)]·xGuest (1-D) and [Cd{sub 3}((S)-CBA){sub 3}(BIP){sub 2}(H{sub 2}O)]·xGuest (1-L), have been synthesized under solvothermal reaction condition. Single crystal X-ray diffraction analysis reveals the two complexes contain single helical chains based on enantiopure ligands and cadmium clusters. Moreover, some physical characteristics such as PXRD, thermal stability, solid-state circular dichroism (CD) and luminescent were also investigated. - Graphical abstract: Utilizing enantiomeric lactic acid derivatives (R)-H{sub 2}CBA and (S)-H{sub 2}CBA to assemble with Cd{sup 2+} ions and ancillary BIP ligands, a couple of 3D homochiral coordination polymers with metal clusters and helical chains have been prepared by hydrothermal reaction. - Highlights: • Chiral lactic acid derivative. • Enantiomeric coordination polymer. • Helical chain. • Trinuclear cadmium cluster.

  1. Hybrid method for designing digital FIR filters based on fractional derivative constraints.

    Science.gov (United States)

    Baderia, Kuldeep; Kumar, Anil; Kumar Singh, Girish

    2015-09-01

    In this manuscript, a hybrid approach based on Lagrange multiplier method and cuckoo search (CS) optimization technique is proposed for the design of linear phase finite impulse response (FIR) filters using fractional derivative constraints. In the proposed method, FIR filter is designed by optimizing the integral squares in passband and stopband from ideal response such that the fractional derivatives of designed filter response become zero at a given frequency point. Lagrange multiplier method is exploited for finding the optimized filter coefficients. Optimal value of fractional derivative constraints for optimized filter coefficients are determined by minimizing the objective function constructed using a sum of maximum passband ripple and maximum stopband ripple in frequency domain using CS algorithm. Performance of the proposed method is evaluated by passband error (ϕ(p)), stopband error (ϕ(s)), stopband attenuation (A(s)), maximum passband ripple (MPR), maximum stopband ripple (MSR) and CPU time. A comparative study of the performance of particle swarm optimization (PSO) and artificial bee colony (ABC) for designing FIR filters using the proposed method is also made. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

  2. Deformation analysis of polymers composites: rheological model involving time-based fractional derivative

    Science.gov (United States)

    Zhou, H. W.; Yi, H. Y.; Mishnaevsky, L.; Wang, R.; Duan, Z. Q.; Chen, Q.

    2017-05-01

    A modeling approach to time-dependent property of Glass Fiber Reinforced Polymers (GFRP) composites is of special interest for quantitative description of long-term behavior. An electronic creep machine is employed to investigate the time-dependent deformation of four specimens of dog-bond-shaped GFRP composites at various stress level. A negative exponent function based on structural changes is introduced to describe the damage evolution of material properties in the process of creep test. Accordingly, a new creep constitutive equation, referred to fractional derivative Maxwell model, is suggested to characterize the time-dependent behavior of GFRP composites by replacing Newtonian dashpot with the Abel dashpot in the classical Maxwell model. The analytic solution for the fractional derivative Maxwell model is given and the relative parameters are determined. The results estimated by the fractional derivative Maxwell model proposed in the paper are in a good agreement with the experimental data. It is shown that the new creep constitutive model proposed in the paper needs few parameters to represent various time-dependent behaviors.

  3. Steganalysis of content-adaptive JPEG steganography based on Gauss partial derivative filter bank

    Science.gov (United States)

    Zhang, Yi; Liu, Fenlin; Yang, Chunfang; Luo, Xiangyang; Song, Xiaofeng; Lu, Jicang

    2017-01-01

    A steganalysis feature extraction method based on Gauss partial derivative filter bank is proposed in this paper to improve the detection performance for content-adaptive JPEG steganography. Considering that the embedding changes of content-adaptive steganographic schemes are performed in the texture and edge regions, the proposed method generates filtered images comprising rich texture and edge information using Gauss partial derivative filter bank, and histograms of absolute values of filtered subimages are extracted as steganalysis features. Gauss partial derivative filter bank can represent texture and edge information in multiple orientations with less computation load than conventional methods and prevent redundancy in different filtered images. These two properties are beneficial in the extraction of low-complexity sensitive features. The results of experiments conducted on three selected modern JPEG steganographic schemes-uniform embedding distortion, JPEG universal wavelet relative distortion, and side-informed UNIWARD-indicate that the proposed feature set is superior to the prior art feature sets-discrete cosine transform residual, phase aware rich model, and Gabor filter residual.

  4. Quantifying rainfall-derived inflow and infiltration in sanitary sewer systems based on conductivity monitoring

    Science.gov (United States)

    Zhang, Mingkai; Liu, Yanchen; Cheng, Xun; Zhu, David Z.; Shi, Hanchang; Yuan, Zhiguo

    2018-03-01

    Quantifying rainfall-derived inflow and infiltration (RDII) in a sanitary sewer is difficult when RDII and overflow occur simultaneously. This study proposes a novel conductivity-based method for estimating RDII. The method separately decomposes rainfall-derived inflow (RDI) and rainfall-induced infiltration (RII) on the basis of conductivity data. Fast Fourier transform was adopted to analyze variations in the flow and water quality during dry weather. Nonlinear curve fitting based on the least squares algorithm was used to optimize parameters in the proposed RDII model. The method was successfully applied to real-life case studies, in which inflow and infiltration were successfully estimated for three typical rainfall events with total rainfall volumes of 6.25 mm (light), 28.15 mm (medium), and 178 mm (heavy). Uncertainties of model parameters were estimated using the generalized likelihood uncertainty estimation (GLUE) method and were found to be acceptable. Compared with traditional flow-based methods, the proposed approach exhibits distinct advantages in estimating RDII and overflow, particularly when the two processes happen simultaneously.

  5. An efficient nonviral gene-delivery vector based on hyperbranched cationic glycogen derivatives

    Directory of Open Access Journals (Sweden)

    Liang X

    2014-01-01

    Full Text Available Xuan Liang,1,* Xianyue Ren,2,* Zhenzhen Liu,1 Yingliang Liu,1 Jue Wang,2 Jingnan Wang,2 Li-Ming Zhang,1 David YB Deng,2 Daping Quan,1 Liqun Yang1 1Institute of Polymer Science, School of Chemistry and Chemical Engineering, Key Laboratory of Designed Synthesis and Application of Polymer Material, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-Sen University, Guangzhou, People's Republic of China; 2Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China *Both these authors contributed equally to this work Background: The purpose of this study was to synthesize and evaluate hyperbranched cationic glycogen derivatives as an efficient nonviral gene-delivery vector. Methods: A series of hyperbranched cationic glycogen derivatives conjugated with 3-(dimethylamino-1-propylamine (DMAPA-Glyp and 1-(2-aminoethyl piperazine (AEPZ-Glyp residues were synthesized and characterized by Fourier-transform infrared and hydrogen-1 nuclear magnetic resonance spectroscopy. Their buffer capacity was assessed by acid–base titration in aqueous NaCl solution. Plasmid deoxyribonucleic acid (pDNA condensation ability and protection against DNase I degradation of the glycogen derivatives were assessed using agarose gel electrophoresis. The zeta potentials and particle sizes of the glycogen derivative/pDNA complexes were measured, and the images of the complexes were observed using atomic force microscopy. Blood compatibility and cytotoxicity were evaluated by hemolysis assay and MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay, respectively. pDNA transfection efficiency mediated by the cationic glycogen derivatives was evaluated by flow cytometry and fluorescence microscopy in the 293T (human embryonic kidney and the CNE2 (human nasopharyngeal carcinoma cell lines. In vivo delivery of pDNA in model animals (Sprague Dawley

  6. Complexes of trivalent lanthanide ions with schiff base derived from vanillin and triethylenetetraamine

    International Nuclear Information System (INIS)

    Shahma, A.; Athar, M.; Ahmad, N.

    1982-01-01

    Complexes of lanthanide(III) ions with the schiff base derived from vanillin and triethylenetetraamine have been synthesised and characterised on the basis of elemental analyses, molar conductance, magnetic moment, IR and thermal analysis data. The thermograms show the elimination (OH)(OCH 3 )C 6 H 3 CH-group at low temperatures before the elimination of triethylenetetraamine part corroborating the observation made on the basis of IR spectral data. This is a clear indication of the non-coordination of the phenolic hydroxyl groups. The lanthanide ions in the complexes exhibit eight coordination numbers. (author)

  7. Electrochemical Biosensors Based on Ferroceneboronic Acid and Its Derivatives: A Review

    Directory of Open Access Journals (Sweden)

    Baozhen Wang

    2014-07-01

    Full Text Available We review recent progress in the development of electrochemical biosensors based on ferroceneboronic acid (FcBA and ferrocene (Fc-modified boronic acids. These compounds can be used to construct electrochemical biosensors because they consist of a binding site (i.e., a boronic acid moiety and an electrochemically active part (i.e., an Fc residue. By taking advantage of the unique properties of FcBA and its derivatives, electrochemical sensors sensitive to sugars, glycated hemoglobin (HbA1c, fluoride (F− ions, and so forth have been widely studied. FcBA-based sugar sensors rely on the selective binding of FcBA to 1,2- or 1,3-diol residues of sugars through the formation of cyclic boronate ester bonds. The redox properties of FcBA-sugar adduct differ from those of free FcBA, which forms the basis of the electrochemical determination of sugars. Thus, non-enzymatic glucose sensors are now being actively studied using FcBA and Fc-modified boronic acids as redox markers. Using a similar principle, HbA1c can be detected by FcBA-based electrochemical systems because it contains hydrocarbon chains on the polypeptide chain. HbA1c sensors are useful for monitoring blood glucose levels over the preceding 8–12 weeks. In addition, FcBA and Fc-modified boronic acids have been used for the detection of F− ions due to the selective binding of boronic acid to F− ions. F−-ion sensors may be useful alternatives to conventional ion-selective electrodes sensitive to F− ion. Furthermore, FcBA derivatives have been studied to construct lectin; steroids; nucleotides; salicylic acid; and bacteria sensors. One of the limitations of FcBA-based sensors comes from the fact that FcBA derivatives are added in sample solutions as reagents. FcBA derivatives should be immobilized on the surface of electrodes for developing reagentless sensors.

  8. Role of geometry, substrate and atmosphere on performance of OFETs based on TTF derivatives

    OpenAIRE

    Marszalek, T.; Nosal, A.; Pfattner, R.; Jung, J.; Kotarba, S.; Mas-Torrent, M.; Krause, B.; Veciana, J.; Gazicki-Lipman, M.; Crickert, C.; Schmidt, G.; Rovira, C.; Ulanski, J.

    2012-01-01

    We report a comparative study of OFET devices based on zone-cast layers of three tetrathiafulvalene (TTF) derivatives in three configurations of electrodes in order to determine the best performing geometry. The first testing experiments were performed using SiO 2/Si substrates. Then the optimum geometry was employed for the preparation of flexible OFETs using Parylene C as both substrate and dielectric layer yielding, in the best case, to devices with μ FET = 0.1 cm 2/V s. With the performed...

  9. Scenario-based approach adopted in the ELECTRA project for deriving innovative control room functionality

    DEFF Research Database (Denmark)

    Marinelli, Mattia; Heussen, Kai; Prostejovsky, Alexander Maria

    2017-01-01

    Here, the authors analyse the operator point of view of the Web-of-Cells concept defined in the EU project ELECTRA, by identifying operator tasks into the supervision of a highly automated power system, and the information requirements to facilitate appropriate operator situation awareness....... The study outlines the methodology adopted, which is based on the cognitive work analysis framework, to provide an overview of the most interesting scenarios and to summarise the requirements analysis results. In order to derive required control room functionality, a set of relevant control room scenarios...

  10. An efficient physically based parameterization to derive surface solar irradiance based on satellite atmospheric products

    Science.gov (United States)

    Qin, Jun; Tang, Wenjun; Yang, Kun; Lu, Ning; Niu, Xiaolei; Liang, Shunlin

    2015-05-01

    Surface solar irradiance (SSI) is required in a wide range of scientific researches and practical applications. Many parameterization schemes are developed to estimate it using routinely measured meteorological variables, since SSI is directly measured at a very limited number of stations. Even so, meteorological stations are still sparse, especially in remote areas. Remote sensing can be used to map spatiotemporally continuous SSI. Considering the huge amount of satellite data, coarse-resolution SSI has been estimated for reducing the computational burden when the estimation is based on a complex radiative transfer model. On the other hand, many empirical relationships are used to enhance the retrieval efficiency, but the accuracy cannot be guaranteed out of regions where they are locally calibrated. In this study, an efficient physically based parameterization is proposed to balance computational efficiency and retrieval accuracy for SSI estimation. In this parameterization, the transmittances for gases, aerosols, and clouds are all handled in full band form and the multiple reflections between the atmosphere and surface are explicitly taken into account. The newly proposed parameterization is applied to estimate SSI with both Moderate Resolution Imaging Spectroradiometer (MODIS) atmospheric and land products as inputs. These retrievals are validated against in situ measurements at the Surface Radiation Budget Network and at the North China Plain on an instantaneous basis, and moreover, they are validated and compared with Global Energy and Water Exchanges-Surface Radiation Budget and International Satellite Cloud Climatology Project-flux data SSI estimates at radiation stations of China Meteorological Administration on a daily mean basis. The estimation results indicates that the newly proposed SSI estimation scheme can effectively retrieve SSI based on MODIS products with mean root-mean-square errors of about 100 Wm- 1 and 35 Wm- 1 on an instantaneous and daily

  11. T1 relaxivities of gadolinium-based magnetic resonance contrast agents in human whole blood at 1.5, 3, and 7 T.

    Science.gov (United States)

    Shen, Yaqi; Goerner, Frank L; Snyder, Christopher; Morelli, John N; Hao, Dapeng; Hu, Daoyu; Li, Xiaoming; Runge, Val M

    2015-05-01

    Calculation of accurate T1 relaxivity (r1) values for gadolinium-based magnetic resonance contrast agents (GBCAs) is a complex process. As such, often referenced r1 values for the GBCAs at 1.5 T, 3 T, and 7 T are based on measurements obtained in media that are not clinically relevant, derived from only a small number of concentrations, or available for only a limited number of GBCAs. This study derives the r1 values of the 8 commercially available GBCAs in human whole blood at 1.5 T, 3 T, and 7 T. Eight GBCAs were serially diluted in human whole blood, at 7 concentrations from 0.0625 to 4 mM. A custom-built phantom held the dilutions in air-tight cylindrical tubes maintained at 37 ± 0.5°C by a heat-circulating system. Images were acquired using inversion recovery sequences with inversion times from 30 milliseconds to 10 seconds at 1.5 T and 3 T as well as 60 milliseconds to 5 seconds at 7 T. A custom MATLAB program was used to automate signal intensity measurements from the images acquired of the phantom. SigmaPlot was used to calculate T1 relaxation times and, finally, r1. Measured r1 values in units of s⁻¹·mM⁻¹ at 1.5 T (3 T/7 T) were 3.9 ± 0.2 (3.4 ± 0.4/2.8 ± 0.4) for Gd-DOTA, 4.6 ± 0.2 (4.5 ± 0.3/4.2 ± 0.3) for Gd-DO3A-butrol, 4.3 ± 0.4 (3.8 ± 0.2/3.1 ± 0.4) for Gd-DTPA, 6.2 ± 0.5 (5.4 ± 0.3/4.7 ± 0.1) for Gd-BOPTA, 4.5 ± 0.1 (3.9 ± 0.2/3.7 ± 0.2) for Gd-DTPA-BMA, 4.4 ± 0.2 (4.2 ± 0.2/4.3 ± 0.2) for Gd-DTPA-BMEA, 7.2 ± 0.2 (5.5 ± 0.3/4.9 ± 0.1) for Gd-EOB-DTPA, and 4.4 ± 0.6 (3.5 ± 0.6/3.4 ± 0.1) for Gd-HP-DO3A. The agents can be stratified by relaxivity, with a significant additional dependency on field strength. This report quantifies, for the first time, T1 relaxivity for all 8 gadolinium chelates in common clinical use worldwide, at current relevant field strengths, in human whole blood at physiological temperature (37°C). The measured r1 values differ to a small degree from previously published values, where such

  12. A Comparison of Vertical Deformations Derived from Space-based Gravimetry, Ground-based Sensors, and Model-based Hydrologic Loading over the Western United States

    Science.gov (United States)

    Yin, G.; Forman, B. A.; Loomis, B. D.; Luthcke, S. B.

    2017-12-01

    Vertical deformation of the Earth's crust due to the movement and redistribution of terrestrial freshwater can be studied using satellite measurements, ground-based sensors, hydrologic models, or a combination thereof. This current study explores the relationship between vertical deformation estimates derived from mass concentrations (mascons) from the Gravity Recovery and Climate Experiment (GRACE), vertical deformation from ground-based Global Positioning System (GPS) observations collected from the Plate Boundary Observatory (PBO), and hydrologic loading estimates based on model output from the NASA Catchment Land Surface Model (Catchment). A particular focus is made to snow-dominated basins where mass accumulates during the snow season and subsequently runs off during the ablation season. The mean seasonal cycle and the effects of atmospheric loading, non-tidal ocean loading, and glacier isostatic adjustment (GIA) are removed from the GPS observations in order to derive the vertical displacement caused predominately by hydrological processes. A low-pass filter is applied to GPS observations to remove high frequency noise. Correlation coefficients between GRACE- and GPS-based estimates at all PBO sites are calculated. GRACE-derived and Catchment-derived displacements are subtracted from the GPS height variations, respectively, in order to compute the root mean square (RMS) reduction as a means of studying the consistency between the three different methods. Results show that in most sites, the three methods exhibit good agreement. Exceptions to this generalization include the Central Valley of California where extensive groundwater pumping is witnessed in the GRACE- and GPS-based estimates, but not in the Catchment-based estimates because anthropogenic groundwater pumping activities are not included in the Catchment model. The relatively good agreement between GPS- and GRACE-derived vertical crustal displacements suggests that ground-based GPS has tremendous

  13. Modification of a two blood sample method used for measurement of GFR with 99mTc-DTPA.

    Science.gov (United States)

    Surma, Marian J; Płachcińska, Anna; Kuśmierek, Jacek

    2018-01-01

    Measurements of GFR may be performed with a slope/intercept method (S/I), using only two blood samples taken in strictly defined time points. The aim of the study was to modify this method in order to extend time intervals suitable for blood sampling. Modification was based on a variation of a Russel et al. model parameter, selection of time intervals suitable for blood sampling and assessment of uncertainty of calculated results. Archived values of GFR measurements of 169 patients with different renal function, from 5.5 to 179 mL/min, calculated with a multiple blood sample method were used. Concentrations of a radiopharmaceutical in consecutive minutes, from 60th to 190th after injection, were calculated theoretically, using archived parameters of biexponential functions describing a decrease in 99mTc-DTPA concentration in blood plasma with time. These values, together with injected activities, were treated as measurements and used for S/I clearance calculations. Next, values of S/I clearance were compared with the multiple blood sample method in order to calculate suitable values of exponent present in a Russel's model, for every combination of two blood sampling time points. A model was considered accurately fitted to measured values when SEE ≤ 3.6 mL/min. Assessments of uncertainty of obtained results were based on law of error superposition, taking into account mean square prediction error and also errors introduced by pipetting, time measurement and stochastic radioactive decay. The accepted criteria resulted in extension of time intervals suitable for blood sampling to: between 60 and 90 minutes after injection for the first sample and between 150 and 180 minutes for the second sample. Uncertainty of results was assessed as between 4 mL/min for GFR = 5-10 mL/min and 8 mL/min for GFR = 180 mL/min. Time intervals accepted for blood sampling fully satisfy nuclear medicine staff and ensure proper determination of GFR. Uncertainty of results is entirely

  14. MR imaging of the biliary tract with Gd-EOB-DTPA: Effect of liver function on signal intensity

    Energy Technology Data Exchange (ETDEWEB)

    Takao, Hidemasa, E-mail: takaoh-tky@umin.ac.jp [Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan); Akai, Hiroyuki; Tajima, Taku [Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan); Kiryu, Shigeru [Department of Radiology, Institute of Medical Science, University of Tokyo, 74-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639 (Japan); Watanabe, Yasushi [Department of Radiological Technology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan); Imamura, Hiroshi [Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431 (Japan); Akahane, Masaaki; Yoshioka, Naoki [Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan); Kokudo, Norihiro [Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan); Ohtomo, Kuni [Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan)

    2011-02-15

    Objective: To quantitatively evaluate the signal intensity of the biliary tract in gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) imaging and to investigate the effect of liver function on the signal intensity of the biliary tract. Materials and methods: A total of 32 patients with and without chronic liver disease (normal liver group, n = 15; chronic liver disease group, n = 17) were included in this study. All patients were prospectively enrolled for evaluation of known or suspected focal liver lesions. In the chronic liver disease group, the etiologies were chronic hepatitis C virus infection (n = 12) and chronic hepatitis B virus infection (n = 5). The median Child-Pugh score was 5 (range, 5-7). Each patient received the standard dose of Gd-EOB-DTPA (0.025 mmol/kg of body weight). Post-contrast T1-weighted MR images were obtained at 5, 10, 15, 20, 25, and 30 min after administration of Gd-EOB-DTPA. Maximum signal intensities (SIs) of the right and left hepatic ducts, common hepatic duct, and common bile duct were measured. Relative signal intensity was calculated as follows: relative SI = maximum SI{sub bileduct}/mean SI{sub muscle}. Serum albumin level, serum total bilirubin level, prothrombin time, indocyanine green retention rate at 15 min (ICG-R15), and estimated glomerular filtration rate were entered into regression analysis. Results: The signal intensity of the bile duct reached a peak 30 min after administration of Gd-EOB-DTPA. The mean relative signal intensity of the right and left hepatic ducts at the peak time point was not significantly different between the two groups, while increase in signal intensity was delayed in the chronic liver disease group. The mean relative signal intensity of the common hepatic duct and that of the common bile duct at the peak time point were significantly different between the two groups (Wilcoxon rank-sum test, P = 0.03, respectively). Stepwise regression

  15. Gd-EOB-DTPA-enhanced-MR imaging in the inflammation stage of nonalcoholic steatohepatitis (NASH) in mice.

    Science.gov (United States)

    Yamada, Tomomi; Obata, Atsushi; Kashiwagi, Yuto; Rokugawa, Takemi; Matsushima, Shuuichi; Hamada, Tadateru; Watabe, Hiroshi; Abe, Kohji

    2016-07-01

    The purpose of this study is to investigate the correlation between the liver kinetics of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) and liver histopathology in a mouse model of NASH by using dynamic contrast-enhanced MRI. Twenty male C57/BL6 mice aged 8weeks were fed a methionine-choline-deficient (MCD) diet for 2, 4 and 6weeks (MCD groups: MCD 2w, 4w, or 6w). Gd-EOB-DTPA-enhanced MR imaging of the liver was performed at 2, 4 and 6weeks after the MCD feeding. The signal intensity of the liver was obtained from dynamic MR images and relative enhancement (RE), and the time to maximum RE (Tmax) and half-life of elimination RE (T1/2) were calculated. After MRI scan, histopathological scores of hepatic steatosis and inflammation and blood biochemistry data, such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, were obtained. Plasma AST and ALT levels were significantly increased in mice fed MCD. Histopathological scores indicated that steatohepatitis progressed with the MCD feeding period from 2 to 6weeks, but significant fibrosis was observed only in mice fed MCD for 6weeks. Gd-EOB-DTPA-enhanced MRI showed that Tmax was significantly prolonged in the livers of the 6-week group compared to the control group (control, 4.0±0.7min; MCD 6w, 12.1±1.6min), although there was no alteration in the 2- and 4-week groups. T1/2 was significantly prolonged in mice fed MCD for 4 and 6weeks compared to the control group (control, 19.9±2.0min; MCD 4w, 46.7±8.7min; MCD 6w, 65.4±8.8min). The parameters of Gd-EOB-DTPA kinetics (Tmax and T1/2) in the liver were positively correlated with the liver histopathological score (steatosis vs Tmax, rho=0.69, P=0.0007; inflammation vs Tmax, rho=0.66, P=0.00155; steatosis vs T1/2, rho=0.77, Pmouse model of NASH, suggesting the possibility of detecting the steatohepatitis stage without fibrosis by Gd-EOB-DTPA-enhanced MR imaging. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. MRT of scaphoid pseudo-arthrosis using Gd-DTPA. Staging and clinical correlation

    International Nuclear Information System (INIS)

    Vogl, T.J.; Beutel, F.; Wilhelm, K.; Tempka, A.; Schedel, H.; Haas, R.; Felix, R.

    1994-01-01

    During a period of two years, 134 patients with pseudo-arthrosis of the scaphoid were examined by conventional radiography and by MRI in the course of a prospective study. The aim of the study was to define radiological staging using contrast enhanced MRI in order to improve the prognostic criteria. All MRI examinations were carried out with a 1.5 Tesla scanner (SP63) using a surface coil and T 1 weighted spin echo sequences in sagittal and frontal projection and frontal FLASH T 2 -sequences and axial spin echo T 2 sequences. The T 1 weighted SE sequences in frontal projection were carried out before and after iv contrast (0.1 mmol Gd-DTPA/kg KG). All sequences were compared with conventional radiographs and the operative findings. Eight patients in stage 0 showed high signal intensity of both fragments in T 1 weighted SE sequences and at surgery there was good vascularisation. In 22 cases there was reduced signal intensity in at least one fragment (stage I). 45 patients with scaphoid pseudo-arthrosis showed complete signal loss but marked contrast uptake with still vital nuclei at surgery (stage II). In 22 patients, there was no increase in signal intensity after contrast and complete loss of vitality of the fragments at surgery. Staging was not possible in 37 patients because of previous operative intervention. The use of contrast enhanced MRI provides additional information compared with conventional radiography or plain MRI. (orig.) [de

  17. Captopril {sup 99m}Tc-DTPA Renal Scintigraphy in Diagnosis of Renovascular Hypertension

    Energy Technology Data Exchange (ETDEWEB)

    Yang, In Hyung; Lee, Dong Soo; Kim, Sung Chul [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1992-07-15

    To evaluate the sensitivity and specificity of captopril renal scan for renovascular hypertension, we employed the captopril renal scan in conjunction with renal angiography in 81 patients, 159 kidneys, who were referred to evaluate the cause of hypertension. We defined the renovascular hypertension by the criteria of demonstration of renal artery stenosis by angiography, and improvement or cure of hypertension by revascularization. Visual and quantitative evaluation of {sup 99m}Tc-DTPA renal scan was performed pre and post captopril administration. The prevalence rate of renovascular hypertension was 40% in comparing with renal angiography, and 70% in confirmed cases. The causes of renovascular hypertension in 81 patients were Takayasu's arteritis, fibromuscular dysplasia, atherosclerosis, essential hypertension, chronic pyelonephritis etc. The sensitivity and specificity of captopril renal scan in comparing with renal angiography were 80%, 86.5%, respectively and also 84.2%, 72.6% in confirmed cases of renovascular hypertension, respectively. The causes of false negative cases were nonfunctioning kidney due to complete obstruction or long duration of disease in basal scan, segmental branch artery stenosis, unknown causes, and suspicious true negative cases without confirmation. The false positive cases were abdominal aortic stenosis or aneurysm, dehydration, unknown causes, and suspicious true positive cases. We conclude that captopril renal scintigraphy is highly sensitive, reasonably specific diagnostic method and comparable to other techniques very favorably.

  18. Captopril 99mTc-DTPA Renal Scintigraphy in Diagnosis of Renovascular Hypertension

    International Nuclear Information System (INIS)

    Yang, In Hyung; Lee, Dong Soo; Kim, Sung Chul

    1992-01-01

    To evaluate the sensitivity and specificity of captopril renal scan for renovascular hypertension, we employed the captopril renal scan in conjunction with renal angiography in 81 patients, 159 kidneys, who were referred to evaluate the cause of hypertension. We defined the renovascular hypertension by the criteria of demonstration of renal artery stenosis by angiography, and improvement or cure of hypertension by revascularization. Visual and quantitative evaluation of 99m Tc-DTPA renal scan was performed pre and post captopril administration. The prevalence rate of renovascular hypertension was 40% in comparing with renal angiography, and 70% in confirmed cases. The causes of renovascular hypertension in 81 patients were Takayasu's arteritis, fibromuscular dysplasia, atherosclerosis, essential hypertension, chronic pyelonephritis etc. The sensitivity and specificity of captopril renal scan in comparing with renal angiography were 80%, 86.5%, respectively and also 84.2%, 72.6% in confirmed cases of renovascular hypertension, respectively. The causes of false negative cases were nonfunctioning kidney due to complete obstruction or long duration of disease in basal scan, segmental branch artery stenosis, unknown causes, and suspicious true negative cases without confirmation. The false positive cases were abdominal aortic stenosis or aneurysm, dehydration, unknown causes, and suspicious true positive cases. We conclude that captopril renal scintigraphy is highly sensitive, reasonably specific diagnostic method and comparable to other techniques very favorably.

  19. Kinetic study of the reduction of Ferric-1, 10-Orthophenanthroline with Uranium (IV) DTPA

    International Nuclear Information System (INIS)

    Perveen, Rashida; Naqvi, Iftikhar Imam

    2006-01-01

    The reduction of ferric 1, 10-orthophenanthroline by Uranium (IV) complex of Diethylenetriaminepentaacetic acid was investigated in aqueous hydrochloride acid at 30C, ionic strength 0.01 mole dm-3 and pH 3.5. The mechanism and rate law for the formation of [Fe (opt) 3] was established by isolation method at constant and varying pH values. Spectroscopic method was employed for this investigation. The rate constant and order of reaction with respect to each of the reactant the [U (IV) DTPA] and [Fe(opt3)] was established by plotting a graph 1n (A-At) vs. time. The reaction was observed to be following first order with respect each of following reactants. Overall reaction order was found to be two, having the value of the rate constant 571.59 m min. at pH 3.5. Thermodynamic parameters for the reaction were determined to be E=26.47 kj mol, G=35.11 kj mol, H=24.86 mol and S= 50.17 mol. With the help of Arrhenius equation activation energy for the reaction was calculated. Change in enthalpy and entropy for the reaction (S, H) were determined from the slope and intercept of Eyring plot. Hydrogen ion dependence of the reaction was determined by varying the pH and the rate law was determined. (author)

  20. MRI enhancement of the facial nerve with Gd-DTPA, 2

    International Nuclear Information System (INIS)

    Yanagida, Masahiro

    1993-01-01

    We performed enhanced MRI using Gd-DTPA in 84 patients with facial palsy. After assessing enhancement of the normal facial nerve, we examined enhancement in patients with Bell's palsy and Ramsay Hunt syndrome. In 95% of patients with Bell's palsy, enhancement was obtained in the distal IAC and labyrinthine portions. In 72%, enhancement was significant from the distal IAC portion through the vertical portion. In some of the patients who underwent enhanced MRI twice, increased signal intensity was observed in distal portions such as the vertical portion. In many cases of Ramsay Hunt syndrome, enhancement was seen extensively in the IAC portion through the vertical portion. In the subjects with internal auditory symptoms such as vertigo and tinnitus, enhancement of the IAC portion was seen not only in the facial nerve but also in the vestibular and the cochlear nerves. These results suggest that the vascular permeability of lesions in Bell's palsy may be increased from the distal IAC portion to the vertical portion. Judging from the present findings with Ramsay Hunt syndrome, symptoms related to the enhanced portions suggest that accompanying internal auditory symptoms occur due to inflammation of the IAC portions of cochlear and vestibular nerves. (author)

  1. Liver hemangiona and metastasis: dynamic study with Gd-DTPA in magnetic resonance

    International Nuclear Information System (INIS)

    Ferrer, M.D.; Marti-Bonmati, L.; Martinez-Rodrigo, J.; Galant, J.

    1993-01-01

    The difference between liver hemangioma and metastases is a subject of clinical interest. Nineteen MR liver studies are presented, 10 of them correspond to hemangiomas and 9 to metastases. In all cases, intravenous gadolinium was used in dynamic slices with T1-weighted gradient echo sequences. Late uptake is studied in two lesions. One minute postinjection, the periphery appears hyperintense (more so than the fatty tissue) in 7 out of the 10 cases of hemangioma; in 4 cases, the metastases show less intense uptake than fatty tissue. From two and a half minutes on, the periphery is hyperintense (more so than the fatty tissue) in all the hemangiomas, while in 4 metastases, the periphery is hyperintense (but less so than the fatty tissue), and the rest of the metastases remain hypo-isointense. Uptake by the hemangiomas at two hours reveals the isointense lesion with the liver. In conclusion, at approximately one minute postinjection, hemangiomas show very marked and nodular uptake, with centripetal progression; the hypersignal persists in late slices. However, the metastases present variable, moderate, irregular uptake at the beginning, with no central progression and reduced contrast in the late slices at 5 minutes. In some cases, Gd-DTPA increases the diagnostic certainty, improving reliability with respect to conventional MR. (Author)

  2. Differential pulse polarographic determination of Sn (II) in DTPA radiopharmaceutical compound

    International Nuclear Information System (INIS)

    Mohamad Hadzri Yaacob; Fielden, P.R.

    1994-01-01

    A differential pulse polarographic technique has been developed for the assay of Sn(II). Acting as a reducing agent, Sn(II) is one of the most important components in radiopharmaceutical compounds. Under optimum conditions, Sn(II) undergoes reduction to form an amalgam at the dropping mercury electrode, producing a well-defined and characteristic peak at -0.45 + 0.030V, with respect to the standard calomel electrode (SCE) in 5M perchloric acid. For quantitative determination by this technique, a linear calibration graph was obtained over a concentration 0 to 70 ppm of stannous chloride for the analysis of diethylenetriamine pentaacetic acid (DTPA) samples. Average recovery from ten measurements of a fixed amount of standard solution was 90%. A detection limit of 2.3ppm which was fairly low compared to the actual content of Sn(II) which was 20 ppm, could be obtained. The analysis of the sample using this technique gave a well-defined Sn(II)peak without the interference of the chelate compounds present in the sample, and reproducible results with a typical coefficient variation of less than 7% for ten determinations. The results obtained demonstrated that the proposed DPP technique was a convenient, sensitive, accurate and rapid method. The results were in good agreement with those found by iodimetric titration. An advantage of this method is that it is free of interference from the other constituents of the sample, hence there is no need to separate the matrix

  3. Assessment of fixed charge density in regenerated cartilage by Gd-DTPA-enhanced MRI

    International Nuclear Information System (INIS)

    Miyata, Shogo; Homma, Kazuhiro; Numano, Tomokazu; Furukawa, Katsuko; Tateishi, Tetsuya; Ushida, Takashi

    2006-01-01

    Applying regenerated cartilage in a clinical setting requires noninvasive evaluation to detect the maturity of cartilage tissue. Magnetic resonance (MR) imaging of articular cartilage is well accepted and has been applied clinically in recent years. We attempt to establish a noninvasive method to evaluate the maturity of regenerated cartilage tissue using gadolinium-enhanced MR imaging. To reconstruct cartilaginous tissue, we embedded articular chondrocytes harvested from bovine humeral head in agarose gel and cultured the cells in vitro up to 4 weeks. The fixed charge density (FCD) of the cartilage was determined using MRI gadolinium exclusion method. The sulfated glycosaminoglycan (sGAG) content was determined by dimethylmethylene blue dye-binding assay. The sGAG content and FCD of the regenerated cartilage increased with duration of culture. In the T 1 Gd maps, the [Gd-DTPA 2- ] in the specimen decreased, and the boundary between the sample disk and the bath solution of phosphate buffered saline (PBS) became clearer as time in culture increased. In the linear regression analysis, FCD and sGAG content correlated significantly. Gadolinium-enhanced MR imaging measurements can be useful predictors of the degree of cartilaginous tissue formation. (author)

  4. Tc-99m-DTPA renal scintigraphy and detection of intrarenal reflux

    International Nuclear Information System (INIS)

    Poropat, M.; Basic, M.; Dodig, D.; Batinic, D.; Nizic, Lj.

    1994-01-01

    The intrarenal reflux plays the key role in the etiology of reflux nephropathy and its detection is of utmost importance in evaluating possible damage in kidney with reflux. In 176 kidneys (113 children) with different degree of vesicoureteric reflux (VUR), dynamic renal scintigraphy with Tc-99m-DTPA in zoom mode was performed. From each study 6 functional images of mean time were generated, kidney contour superimposed on each, and time activity curves (TAC) over possible areas of increased mean time were generated. In these study we analyzed only areas of increased mean time over the outer contour of the kidney which corresponds to the renal parenchyma. In later functional images of the mean time we found 53 focal retentions over the part of the kidney which corresponds to the renal cortex (33 in upper, 5 in middle and 15 in lower part of the kidney). TAC-s generated over these areas exhibited a sharp increase of activity on the descending part of the curves. We propose that the return of activity from the collecting system to the kidney cortex represents intrarenal reflux. In our opinion, analysis of functional images of the mean time could be a method for more accurate detection of intrarenal reflux and indicating the children with high risk to acquire renal scarring. (author)

  5. Absolute renal blood flow quantification by dynamic MRI and Gd-DTPA

    International Nuclear Information System (INIS)

    Vallee, J.P.; Lazeyras, F.; Khan, H.G.; Terrier, F.

    2000-01-01

    The aim of this study was to demonstrate the feasibility of the absolute renal blood flow quantification using MRI and injection of contrast media. Using a T1-weighted fast gradient sequence following an intravenous bolus injection of Gd-DTPA, dynamic images of the kidney were obtained in patients with well-functioning native kidneys (n=7) or transplant (n=9), with significant renal artery stenosis (n=4) and with renal failure (n=7). After signal intensity calibration, the absolute renal perfusion was equal to the wash-in slope of the renal transit curve divided by the contrast medium concentration at the peak of the bolus in the aorta. The cortical blood flow was 2.54±1.16 ml/min per gram in well-functioning kidneys decreasing to 1.09±0.75 ml/min per gram in case of renal artery stenosis (p=0.04) and to 0.51 ± 0.34 ml/min per gram in case of renal failure (p<0.001). These measurements were in agreement with previous results obtained by other methods. A standard MRI imaging sequence and a simple model can provide realistic quantitative data on renal perfusion. This work justifies further studies to compare this model with a gold standard for renal blood flow measurements. (orig.)

  6. Contrast-enhanced magnetic resonance cholangiography using gadolinium-EOB-DTPA. Preliminary experience and clinical applications

    International Nuclear Information System (INIS)

    Holzapfel, K.; Breitwieser, C.; Rummeny, E.J.; Gaa, J.; Prinz, C.

    2007-01-01

    Magnetic resonance cholangiopancreaticography (MRCP) with heavily T2-weighted RARE and HASTE sequences has become an important imaging modality for the morphologic evaluation of intra- and extrahepatic bile ducts. However, for the diagnosis of functional biliary disorders, cholangiopancreaticography (ERCP) and endoscopic manometry, two invasive techniques with considerable morbidity and mortality, remain the standard. Biliary scintigraphy, secretin-stimulated MRCP, and secretin-stimulated endoscopic ultrasound have not proven to be sufficient to replace these techniques as they lack diagnostic accuracy and correlate poorly with manometry results. Contrast-enhanced magnetic resonance cholangiography (CE-MRC) uses hepatocyte specifically contrast agents that are eliminated by the biliary system. Therefore, these substances can serve as biliary contrast agents in T1-weighted MR imaging. This method makes a noninvasive functional evaluation of the hepatobiliary system possible. In the present article, our preliminar experience with Gd-EOB-DTPA-enhanced MRC is summarized and potential clinical applications of this method are discussed. Additionally, the article reviews publications evaluating a possible benefit of CE-MRC with other hepathobiliary contrast agents such as mangafodipir trisodium. (orig.)

  7. A genetic algorithm-based weighted ensemble method for predicting transposon-derived piRNAs.

    Science.gov (United States)

    Li, Dingfang; Luo, Longqiang; Zhang, Wen; Liu, Feng; Luo, Fei

    2016-08-31

    Predicting piwi-interacting RNA (piRNA) is an important topic in the small non-coding RNAs, which provides clues for understanding the generation mechanism of gamete. To the best of our knowledge, several machine learning approaches have been proposed for the piRNA prediction, but there is still room for improvements. In this paper, we develop a genetic algorithm-based weighted ensemble method for predicting transposon-derived piRNAs. We construct datasets for three species: Human, Mouse and Drosophila. For each species, we compile the balanced dataset and imbalanced dataset, and thus obtain six datasets to build and evaluate prediction models. In the computational experiments, the genetic algorithm-based weighted ensemble method achieves 10-fold cross validation AUC of 0.932, 0.937 and 0.995 on the balanced Human dataset, Mouse dataset and Drosophila dataset, respectively, and achieves AUC of 0.935, 0.939 and 0.996 on the imbalanced datasets of three species. Further, we use the prediction models trained on the Mouse dataset to identify piRNAs of other species, and the models demonstrate the good performances in the cross-species prediction. Compared with other state-of-the-art methods, our method can lead to better performances. In conclusion, the proposed method is promising for the transposon-derived piRNA prediction. The source codes and datasets are available in https://github.com/zw9977129/piRNAPredictor .

  8. Incomplete data based parameter identification of nonlinear and time-variant oscillators with fractional derivative elements

    Science.gov (United States)

    Kougioumtzoglou, Ioannis A.; dos Santos, Ketson R. M.; Comerford, Liam

    2017-09-01

    Various system identification techniques exist in the literature that can handle non-stationary measured time-histories, or cases of incomplete data, or address systems following a fractional calculus modeling. However, there are not many (if any) techniques that can address all three aforementioned challenges simultaneously in a consistent manner. In this paper, a novel multiple-input/single-output (MISO) system identification technique is developed for parameter identification of nonlinear and time-variant oscillators with fractional derivative terms subject to incomplete non-stationary data. The technique utilizes a representation of the nonlinear restoring forces as a set of parallel linear sub-systems. In this regard, the oscillator is transformed into an equivalent MISO system in the wavelet domain. Next, a recently developed L1-norm minimization procedure based on compressive sensing theory is applied for determining the wavelet coefficients of the available incomplete non-stationary input-output (excitation-response) data. Finally, these wavelet coefficients are utilized to determine appropriately defined time- and frequency-dependent wavelet based frequency response functions and related oscillator parameters. Several linear and nonlinear time-variant systems with fractional derivative elements are used as numerical examples to demonstrate the reliability of the technique even in cases of noise corrupted and incomplete data.

  9. Electronic and Optical Properties of Novel Phases of Silicon and Silicon-Based Derivatives

    Science.gov (United States)

    Ong, Chin Shen; Choi, Sangkook; Louie, Steven

    2014-03-01

    The vast majority of solar cells in the market today are made from crystalline silicon in the diamond-cubic phase. Nonetheless, diamond-cubic Si has an intrinsic disadvantage: it has an indirect band gap with a large energy difference between the direct gap and the indirect gap. In this work, we perform a careful study of the electronic and optical properties of a newly discovered cubic-Si20 phase of Si that is found to sport a direct band gap. In addition, other silicon-based derivatives have also been discovered and found to be thermodynamically metastable. We carry out ab initio GW and GW-BSE calculations for the quasiparticle excitations and optical spectra, respectively, of these new phases of silicon and silicon-based derivatives. This work was supported by NSF grant No. DMR10-1006184 and U.S. DOE under Contract No. DE-AC02-05CH11231. Computational resources have been provided by DOE at Lawrence Berkeley National Laboratory's NERSC facility and the NSF through XSEDE resources at NICS.

  10. Rigid, bio-based polyamides from galactaric acid derivatives with elevated glass transition temperatures and their characterization

    NARCIS (Netherlands)

    Wróblewska, Aleksandra A.; Bernaerts, Katrien; de Wildeman, Stefaan

    2017-01-01

    A comparative study was prepared investigating the synthesis of polyamides using bio-based building blocks derived from sugar beet pulp, namely 2,3:4,5-di-O-methylene-galactarate (GalXH) and 2,3:4,5-di-O-isopropylidene-galactarate (GalXMe) derivatives. Two different approaches towards the synthesis

  11. Proportional derivative based stabilizing control of paralleled grid converters with cables in renewable power plants

    DEFF Research Database (Denmark)

    Wang, Xiongfei; Blaabjerg, Frede; Loh, Poh Chiang

    2014-01-01

    Resonant interactions of grid-connected converters with each other and with cable capacitance are challenging the stability and power quality of renewable energy sources based power plants. This paper addresses the instability of current control of converters with the multiple resonance frequencies...... consisting in LCL filters and cables. Both grid and converter current controls are analyzed. The frequency region, within which the system may be destabilized, is identified by means of the impedance-based stability analysis and frequency-domain passivity theory. A proportional derivative control strategy...... is then proposed to stabilize the system. Simulation case studies on four paralleled grid converters and experimental tests for two paralleled grid converters are carried out to validate the performance of the proposed control....

  12. Synthesis, characterisation and DFT studies of three Schiff bases derived from histamine

    Science.gov (United States)

    Touafri, Lasnouni; Hellal, Abdelkader; Chafaa, Salah; Khelifa, Abdellah; Kadri, Abdelaziz.

    2017-12-01

    In this paper, we report first, the synthesis and characterisation of three Schiff bases derived from histamine by condensation of histamine with various aldehydes. Then, we present a detailed DFT study based on B3LYP/6-31G(d,p) of geometrical structures and electronic properties of these compounds. The study was extended to the HOMO-LUMO analysis to calculate the energy gap (Δ), Ionisation potential (I), Electron Affinity (A), Global Hardness (η), Chemical Potential (μ), Electrophilicity (ω), Electronegativity (χ) and Polarisability (α). The calculated HOMO and LUMO energy reveals that the charge transfers occurring within the molecule. On the basis of vibration analyses, the thermodynamic properties of the titles compound were also calculated.

  13. Clinical applications of naturally derived biopolymer-based scaffolds for regenerative medicine.

    Science.gov (United States)

    Stoppel, Whitney L; Ghezzi, Chiara E; McNamara, Stephanie L; Black, Lauren D; Kaplan, David L

    2015-03-01

    Naturally derived polymeric biomaterials, such as collagens, silks, elastins, alginates, and fibrins are utilized in tissue engineering due to their biocompatibility, bioactivity, and tunable mechanical and degradation kinetics. The use of these natural biopolymers in biomedical applications is advantageous because they do not release cytotoxic degradation products, are often processed using environmentally-friendly aqueous-based methods, and their degradation rates within biological systems can be manipulated by modifying the starting formulation or processing conditions. For these reasons, many recent in vivo investigations and FDA-approval of new biomaterials for clinical use have utilized natural biopolymers as matrices for cell delivery and as scaffolds for cell-free support of native tissues. This review highlights biopolymer-based scaffolds used in clinical applications for the regeneration and repair of native tissues, with a focus on bone, skeletal muscle, peripheral nerve, cardiac muscle, and cornea substitutes.

  14. Sensitivity of diamond-capped impedance transducer to Tröger's base derivative.

    Science.gov (United States)

    Stehlik, Stepan; Izak, Tibor; Kromka, Alexander; Dolenský, Bohumil; Havlík, Martin; Rezek, Bohuslav

    2012-08-01

    Sensitivity of an intrinsic nanocrystalline diamond (NCD) layer to naphthalene Tröger's base derivative decorated with pyrrole groups (TBPyr) was characterized by impedance spectroscopy. The transducer was made of Au interdigitated electrodes (IDE) with 50 μm spacing on alumina substrate which were capped with the NCD layer. The NCD-capped transducer with H-termination was able to electrically distinguish TBPyr molecules (the change of surface resistance within 30-60 kΩ) adsorbed from methanol in concentrations of 0.04 mg/mL to 40 mg/mL. An exponential decay of the surface resistance with time was observed and attributed to the readsorption of air moisture after methanol evaporation. After surface oxidation the NCD cap layer did not show any leakage due to NCD grain boundaries. We analyzed electronic transport in the transducer and propose a model for the sensing mechanism based on surface ion replacement.

  15. Glomerular filtration values obtained with 99mTc-DTPA v/s measurements of creatinine Clearance and calculation of the filtered glomerular using the Schwartz formula in a pediatric population

    International Nuclear Information System (INIS)

    Opazo, Claudio; Gutierrez, Elisa; Zamorano, Julio; Troncoso, TM

    2005-01-01

    We compare glomerular filtration rate by DTPA Renogram (DTPA-GFR) with creatinine clearance (CC) and Glomerular filtration rate from Schwartz formula (Schwartz-GFR). The need for using (DTPA-GFR) method raised from the practical difficulties in getting an accurate (CC) in pediatric population. From Sep-2001 to May-2005, 48 patients aged 1month to 18 years, underwent (DTPA-GFR) and (Schwartz-GFR). 18 had also (CC). Comparison were made among these measurements also accounting for age groups. We found a better correlation between (DTPA-GFR) and (CC) Pearson = 0,895. (Schwartz)/(CC) comparison showed a slightly lower correlation Pearson = 0,857. The worst correlation was found comparing (DTPA-GFR)/(Schwartz-GFR) in children < 3 yr Pearson = 0,560. As we found a better correlation between (DTPA-GFR)/(CC) than (DTPA-GFR)/(Schwartz-GFR), DTPA-GFR could be considered reliable method in evaluating renal function in children having difficulties to get a Creatinine Clearance (au)

  16. Software failure events derivation and analysis by frame-based technique

    International Nuclear Information System (INIS)

    Huang, H.-W.; Shih, C.; Yih, Swu; Chen, M.-H.

    2007-01-01

    A frame-based technique, including physical frame, logical frame, and cognitive frame, was adopted to perform digital I and C failure events derivation and analysis for generic ABWR. The physical frame was structured with a modified PCTran-ABWR plant simulation code, which was extended and enhanced on the feedwater system, recirculation system, and steam line system. The logical model is structured with MATLAB, which was incorporated into PCTran-ABWR to improve the pressure control system, feedwater control system, recirculation control system, and automated power regulation control system. As a result, the software failure of these digital control systems can be properly simulated and analyzed. The cognitive frame was simulated by the operator awareness status in the scenarios. Moreover, via an internal characteristics tuning technique, the modified PCTran-ABWR can precisely reflect the characteristics of the power-core flow. Hence, in addition to the transient plots, the analysis results can then be demonstrated on the power-core flow map. A number of postulated I and C system software failure events were derived to achieve the dynamic analyses. The basis for event derivation includes the published classification for software anomalies, the digital I and C design data for ABWR, chapter 15 accident analysis of generic SAR, and the reported NPP I and C software failure events. The case study of this research includes: (1) the software CMF analysis for the major digital control systems; and (2) postulated ABWR digital I and C software failure events derivation from the actual happening of non-ABWR digital I and C software failure events, which were reported to LER of USNRC or IRS of IAEA. These events were analyzed by PCTran-ABWR. Conflicts among plant status, computer status, and human cognitive status are successfully identified. The operator might not easily recognize the abnormal condition, because the computer status seems to progress normally. However, a well

  17. Clearance of technetium-99m-labeled DTPA in hyperthyroidism without clinical evidence of lung disease, and relation to pulmonary function

    International Nuclear Information System (INIS)

    Guldiken, S.; Tugrul, A.; Altiay, G.; Hacimahmutoglu, S.; Durmus-Altun, G.

    2005-01-01

    The mechanisms of dyspnea and exercise intolerance have not been fully elucidated. We aimed to investigate the clearance rate of technetium-99m diethyltriaminepentaaceticacid (Tc-99m DTPA) from lungs in hyperthyroid patients without clinical evidence of lung disease and to explore the interactions between their Tc-99m DTPA radioaerosol lung scintigraphy, spirometric measurements, and the levels of thyroid hormones. We studied 19 hyperthyroid patients and 16 sex- and age-matched controls. Thyroid hormone levels were assessed. Spirometric lung function tests, diffusing capacity of the lung for carbon monoxide (DLCO) and the clearance rate of Tc-99m DTPA were performed in all participants. Ratio of DLCO value to the alveolar ventilation (DLCO/VA) and the means of half-time (T 1/2 ) of Tc-99m DTPA clearance rate, which were used to evaluate alveolar-capillary membrane permeability, were calculated. There were no statistical differences between spirometric parameters (vital capacity (VC), force vital capacity (FVC), one second forced expiratory volume (FEV 1 )/FVC, mean forced expiratory flow during the middle of FVC (FEF 25-75)) of the two groups (p>0.05). Although the mean FEV 1 level was significantly lower in the hyperthyroid patients than the control subjects (p 1 was only less than 80 percent of the predicted value. No significant difference in the means of DLCO, DLCO/VA or T 1/2 values of Tc-99m DTPA clearance was observed between the two groups (p>0.05). In hyperthyroid patients, there was a positive relation between DLCO/VA, DLCO/VA% and T 1/2 values of Tc-99m DTPA clearance (p 1/2 values of Tc-99m DTPA clearance in hyperthyroid group (p>0.05). We conclude that increased thyroid hormones have no effect on permeability of alveolar-capillary membrane in hyperthyroid patients. (author)

  18. Carbon Molecular Sieve Membranes Derived from Tröger's Base-Based Microporous Polyimide for Gas Separation.

    Science.gov (United States)

    Wang, Zhenggong; Ren, Huiting; Zhang, Shenxiang; Zhang, Feng; Jin, Jian

    2018-03-09

    Carbon molecular sieve (CMS)-based membranes have attracted great attention because of their outstanding gas-separation performance. The polymer precursor is a key point for the preparation of high-performance CMS membranes. In this work, a microporous polyimide precursor containing a Tröger's base unit was used for the first time to prepare CMS membranes. By optimizing the pyrolysis procedure and the soaking temperature, three TB-CMS membranes were obtained. Gas-permeation tests revealed that the comprehensive gas-separation performance of the TB-CMS membranes was greatly enhanced relative to that of most state-of-the-art CMS membranes derived from polyimides reported so far. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Copper(II)-selective membrane electrode based on a recently synthesized naphthol-derivative Schiff's base

    Energy Technology Data Exchange (ETDEWEB)

    Alizadeh, N.; Ershad, S. [Dept. of Chemistry, Tarbiat Moderres Univ., Tehran (Iran); Naeimi, H.; Sharghi, H. [Dept. of Chemistry, Shiraz Univ. (Iran); Shamsipur, M. [Dept. of Chemistry, Razi Univ., Kermanshah (Iran)

    1999-11-01

    A PVC membrane electrode for copper(II) ions based on a recently synthesized naphthol-derivative Schiff's base as membrane carrier was prepared. The sensor exhibits a Nernstian response for Cu{sup 2+} ions over a wide concentration range (5.0 x 10{sup -6}-5.0 x 10{sup -2} mol/L) with a detection limit of 3.1 x 10{sup -6} mol/L (0.2 {mu}g/mL). It has a very short response time of about 5 s and can be used for 3 months without any divergence in potential. The proposed electrode revealed good selectivities over a wide variety of other cations including alkali, alkaline earth, transition and heavy metal ions and could be used in a pH range of 4.0-7.0. It was successfully applied to the direct determination and potentiometric titration of copper ion. (orig.)

  20. Deriving a probabilistic syntacto-semantic grammar for biomedicine based on domain-specific terminologies.

    Science.gov (United States)

    Fan, Jung-Wei; Friedman, Carol

    2011-10-01

    Biomedical natural language processing (BioNLP) is a useful technique that unlocks valuable information stored in textual data for practice and/or research. Syntactic parsing is a critical component of BioNLP applications that rely on correctly determining the sentence and phrase structure of free text. In addition to dealing with the vast amount of domain-specific terms, a robust biomedical parser needs to model the semantic grammar to obtain viable syntactic structures. With either a rule-based or corpus-based approach, the grammar engineering process requires substantial time and knowledge from experts, and does not always yield a semantically transferable grammar. To reduce the human effort and to promote semantic transferability, we propose an automated method for deriving a probabilistic grammar based on a training corpus consisting of concept strings and semantic classes from the Unified Medical Language System (UMLS), a comprehensive terminology resource widely used by the community. The grammar is designed to specify noun phrases only due to the nominal nature of the majority of biomedical terminological concepts. Evaluated on manually parsed clinical notes, the derived grammar achieved a recall of 0.644, precision of 0.737, and average cross-bracketing of 0.61, which demonstrated better performance than a control grammar with the semantic information removed. Error analysis revealed shortcomings that could be addressed to improve performance. The results indicated the feasibility of an approach which automatically incorporates terminology semantics in the building of an operational grammar. Although the current performance of the unsupervised solution does not adequately replace manual engineering, we believe once the performance issues are addressed, it could serve as an aide in a semi-supervised solution. Copyright © 2011 Elsevier Inc. All rights reserved.

  1. Antipathogenic effects of structurally-related Schiff base derivatives: Structure–activity relationship

    Directory of Open Access Journals (Sweden)

    Soleiman Hisaindee

    2015-11-01

    Full Text Available Eighteen structurally-related Schiff base derivatives, which belong to salicylidenebenzylamine and 2-hydroxy-1-naphthylidenebenzylamine families were prepared and characterized by spectroscopic techniques. All the synthesized compounds were screened in vitro for their antibacterial and antifungal activities. Human pathogenic gram-negative (Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa and Serratia marcescens, gram-positive bacteria (Staphylococcus epidermidis, Staphylococcus aureus and Bacillus subtilis, and fungi (Alternaria alternata, Aspergillus niger, Penicillium roqueforti, and Saccharomyces cerevisiae were evaluated based on their toxicity to different concentrations of Schiff base compounds. For assessment of toxicity to pathogens, a disc diffusion assay was used to test the antimicrobial properties. The results revealed some antimicrobial activities of some of the synthesized compounds. Among the tested pathogens, the synthesized salicylidinaniline derivatives show highly potent action towards Alternaria alternata. Interestingly, a compound which contains the –Cl group is only effective against gram negative bacteria, but not gram positive bacteria. No remarkable antibacterial or antifungal activities were observed in the presence of –CH3 or –Br group. Furthermore, most of the naphthalene-containing compounds show no growth retardation towards bacterial or fungal pathogens. On the other hand, the presence of –OH or –SH group at para or ortho position, respectively, on the aniline site is correlated with an increased inhibitory drug effect on all pathogens. The importance of our findings to the drug research and developments is discussed in the context of finding a correlation between the structural properties of the new drugs and their biological activities.

  2. Robust Analysis of Network-Based Real-Time Kinematic for GNSS-Derived Heights

    Directory of Open Access Journals (Sweden)

    Tae-Suk Bae

    2015-10-01

    Full Text Available New guidelines and procedures for real-time (RT network-based solutions are required in order to support Global Navigation Satellite System (GNSS derived heights. Two kinds of experiments were carried out to analyze the performance of the network-based real-time kinematic (RTK solutions. New test marks were installed in different surrounding environments, and the existing GPS benchmarks were used for analyzing the effect of different factors, such as baseline lengths, antenna types, on the final accuracy and reliability of the height estimation. The RT solutions are categorized into three groups: single-base RTK, multiple-epoch network RTK (mRTN, and single-epoch network RTK (sRTN. The RTK solution can be biased up to 9 mm depending on the surrounding environment, but there was no notable bias for a longer reference base station (about 30 km In addition, the occupation time for the network RTK was investigated in various cases. There is no explicit bias in the solution for different durations, but smoother results were obtained for longer durations. Further investigation is needed into the effect of changing the occupation time between solutions and into the possibility of using single-epoch solutions in precise determination of heights by GNSS.

  3. Synthesis and characterization of nickel complexes derived from Schiff-Bases

    Directory of Open Access Journals (Sweden)

    Mirian Y. Matsumoto

    2012-06-01

    Full Text Available Aromatic Schiff-Bases constitute a large class of organic compounds containing the imine group (C=N [1-3]. 2-hydroxybenzaldehyde (salicylaldehyde which has been frequently used for the synthesis of aromatic Schiff-Bases, it has many biological applications, such as analgesics, anti-inflammatory, antibacterial, antiviral and bactericidal activities [4-6]. From above, this project proposed the synthesis of three Schiff bases derived from salicylaldehyde prepared by condensation between salicylaldehyde with different p-substituted anilines (H, NO2 and MeO. Schiff-Bases synthesized were used as starting compound for the synthesis of nickel complexes. The synthesis of nickel complexes were carried out by adding of alcoholic solution of ligands (2 eq. in aqueous solution of NiCl2.6 H2O (1 eq. contain KOH (1eq. 3 hours. After thisMatsumoto et al. time, the reaction was kept to r.t. to obtain a precipitates. The precipitates were filtered under vacuum and they were characterized by GC-MS, FT-IR and UV-Vis

  4. Synthesis, characterization and antibacterial studies of ruthenium(III) complexes derived from chitosan schiff base.

    Science.gov (United States)

    Vadivel, T; Dhamodaran, M

    2016-09-01

    Chitosan can be modified chemically by condensation reaction of deacetylated chitosan with aldehyde in homogeneous phase. This condensation is carried by primary amine (NH2) with aldehyde (CHO) to form corresponding schiff base. The chitosan biopolymer schiff base derivatives are synthesized with substituted aldehydes namely 4-hydroxy-3-methoxy benzaldehyde, 2-hydroxy benzaldehyde, and 2-hydroxy-3-methoxy benzaldehyde, becomes a complexing agent or ligand. The Ruthenium(III) complexes were obtained by complexation of Ruthenium with schiff base ligands and this product exhibits as an excellent solubility and more biocompatibility. The novel series of schiff base Ruthenium(III) complexes are characterized by Elemental analysis, FT-IR spectroscopy, and Thermo-gravimetric analysis (TGA). The synthesized complexes have been subjected to antibacterial study. The antibacterial results indicated that the antibacterial activity of the complexes were more effective against Gram positive and Gram negative pathogenic bacteria. These findings are giving suitable support for developing new antibacterial agent and expand our scope for applications. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Robust Analysis of Network-Based Real-Time Kinematic for GNSS-Derived Heights.

    Science.gov (United States)

    Bae, Tae-Suk; Grejner-Brzezinska, Dorota; Mader, Gerald; Dennis, Michael

    2015-10-26

    New guidelines and procedures for real-time (RT) network-based solutions are required in order to support Global Navigation Satellite System (GNSS) derived heights. Two kinds of experiments were carried out to analyze the performance of the network-based real-time kinematic (RTK) solutions. New test marks were installed in different surrounding environments, and the existing GPS benchmarks were used for analyzing the effect of different factors, such as baseline lengths, antenna types, on the final accuracy and reliability of the height estimation. The RT solutions are categorized into three groups: single-base RTK, multiple-epoch network RTK (mRTN), and single-epoch network RTK (sRTN). The RTK solution can be biased up to 9 mm depending on the surrounding environment, but there was no notable bias for a longer reference base station (about 30 km) In addition, the occupation time for the network RTK was investigated in various cases. There is no explicit bias in the solution for different durations, but smoother results were obtained for longer durations. Further investigation is needed into the effect of changing the occupation time between solutions and into the possibility of using single-epoch solutions in precise determination of heights by GNSS.

  6. Copper extraction by fatty hydroxamic acids derivatives synthesized based on palm kernel oil.

    Science.gov (United States)

    Haron, Jelas; Jahangirian, Hossein; Silong, Sidik; Yusof, Nor Azah; Kassim, Anuar; Moghaddam, Roshanak Rafiee; Peyda, Mazyar; Abdollahi, Yadollah; Amin, Jamileh; Gharayebi, Yadollah

    2012-01-01

    Fatty hydroxamic acids derivatives based on palm kernel oil which are phenyl fatty hydroxamic acids (PFHAs), methyl fatty hydroxamic acids (MFHAs), isopropyl fatty hydroxamic acids (IPFHAs) and benzyl fatty hydroxamic acids (BFHAs) were applied as chelating agent for copper liquid-liquid extraction. The extraction of copper from aqueous solution by MFHAs, PFHAs, BFHAs or IPFHAs were carried out in hexane as an organic phase through the formation of copper methyl fatty hydroxamate (Cu-MFHs), copper phenyl fatty hydroxamate (Cu-PFHs), copper benzyl fatty hydroxamate (Cu-BFHs) and copper isopropyl fatty hydroxamate (Cu-IPFHs). The results showed that the fatty hydroxamic acid derivatives could extract copper at pH 6.2 effectively with high percentage of extraction (the percentages of copper extraction by MFHAs, PFHAs, IPFHs and BFHAs were found to be 99.3, 87.5, 82.3 and 90.2%, respectively). The extracted copper could be quantitatively stripped back into sulphuric acid (3M) aqueous solution. The obtained results showed that the copper recovery percentages from Cu-MFHs, Cu-PFHs, Cu-BFHs and Cu-IPFHs are 99.1, 99.4, 99.6 and 99.9 respectively. The copper extraction was not affected by the presence of a large amount of Mg (II), Ni (II), Al (III), Mn (II) and Co (II) ions in the aqueous solution.

  7. Efficient OLEDs Fabricated by Solution Process Based on Carbazole and Thienopyrrolediones Derivatives

    Directory of Open Access Journals (Sweden)

    Luis-Abraham Lozano-Hernández

    2018-01-01

    Full Text Available Four low molecular weight compounds—three of them new, two of them with carbazole (Cz as functional group and the other two with thienopyrroledione (TPD group—were used as emitting materials in organic light emitting diodes (OLEDs. Devices were fabricated with the configuration ITO/PEDOT:PSS/emitting material/LiF/Al. The hole injector layer (HIL and the emitting sheet were deposited by spin coating; LiF and Al were thermally evaporated. OLEDs based on carbazole derivatives show luminances up to 4130 cd/m2, large current efficiencies about 20 cd/A and, cautiously, a very impressive External Quantum Efficiency (EQE up to 9.5%, with electroluminescence peaks located around 490 nm (greenish blue region. Whereas, devices manufactured with TPD derivatives, present luminance up to 1729 cd/m2, current efficiencies about 4.5 cd/A and EQE of 1.5%. These results are very competitive regarding previous reported materials/devices.

  8. Polyurethane and polyurea nanoparticles based on polyoxyethylene castor oil derivative surfactant suitable for endovascular applications.

    Science.gov (United States)

    Morral-Ruíz, Genoveva; Melgar-Lesmes, Pedro; García, María Luísa; Solans, Conxita; García-Celma, María José

    2014-01-30

    The design of new, safe and effective nanotherapeutic systems is an important challenge for the researchers in the nanotechnology area. This study describes the formation of biocompatible polyurethane and polyurea nanoparticles based on polyoxyethylene castor oil derivative surfactant formed from O/W nano-emulsions by polymerization at the droplet interfaces in systems composed by aqueous solution/Kolliphor(®) ELP/medium chain triglyceride suitable for intravenous administration. Initial nano-emulsions incorporating highly hydrophilic materials were prepared by the phase inversion composition (PIC) method. After polymerization, nanoparticles with a small particle diameter (25-55 nm) and low polydispersity index were obtained. Parameters such as concentration of monomer, O/S weight ratio as well as the polymerization temperature were crucial to achieve a correct formation of these nanoparticles. Moreover, FT-IR studies showed the full conversion of the monomer to polyurethane and polyurea polymers. Likewise the involvement of the surfactant in the polymerization process through their nucleophilic groups to form the polymeric matrix was demonstrated. This could mean a first step in the development of biocompatible systems formulated with polyoxyethylene castor oil derivative surfactants. In addition, haemolysis and cell viability assays evidenced the good biocompatibility of KELP polyurethane and polyurea nanoparticles thus indicating the potential of these nanosystems as promising drug carriers. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Lubricity of bio-based lubricant derived from chemically modified jatropha methyl ester

    Directory of Open Access Journals (Sweden)

    N.W.M. Zulkifli

    2014-06-01

    Full Text Available Many studies have been undertaken with a view to using chemically modified vegetable oil as a bio-based lubricant. This research focused on tribological properties of trimethylolpropane (TMP ester, which is derived from renewable resource. This TMP ester was produced from jatropha methyl ester; it is biodegradable and has high lubricity properties. Two different conditions of lubrication are being investigated: extreme pressure and anti-wear. It was found that the TMP ester (Jatropha has better lubricity in terms of wear and friction compared to paraffin oil under extreme pressure conditions. TMP ester (Jatropha has similar characteristics to fully formulated lubricant (FFL, in terms of the coefficient of friction (CoF. In terms of the anti-wear condition, TMP ester (Jatropha has the lowest CoF; however it also has the high wear scar diameter. This is due to corrosion and chemical attack.

  10. Prediction of rumen microbial outflow based on urinary excretion of purine derivatives

    International Nuclear Information System (INIS)

    Nolan, J.V.

    1999-01-01

    The method for predicting microbial protein outflow from the rumen based on the excretion of purine derivatives (PD) in the urine is being increasingly used by nutritionists. In contrast to methods that depend on estimates of digesta flow, the PD method does not require animals to be fitted surgically with cannulae into the gut, and studies can be performed with minimal disturbance to the experimental animals. Methods of analysis of PD have been improved and standardized. Certain assumptions, however, are required that could lead to errors when this method is used to predict microbial protein outflow from the rumen. The need for further investigation of these assumptions by means of isotopic tracers and other techniques is examined. (author)

  11. Preparation and characterization of polymer blends based on recycled PET and polyester derived by terephthalic acid

    International Nuclear Information System (INIS)

    Ohara, L.; Miranda, C.S.; Fiuza, R.P.; Luporini, S.; Carvalho, R.F.; Jose, N.M.

    2010-01-01

    Environmentally friendly materials, made from industrial waste, are being increasingly used as a solution to the growing amount of waste generated by society, but also as a cheaper alternative to replace conventional materials for use in construction. In this work were investigated the properties of polymer blends based on recycled PET and a polyester derived from terephthalic acid and glycerin, a co-product of biodiesel. The samples were characterized by XRD, TGA, DSC, FTIR and SEM. The polyester synthesized showed a degradation event near 300 deg C. The blends with higher ratio of PET showed thermal behavior similar to pure PET. The X-ray diffraction showed that the polymer blends are semicrystalline materials. The micrographs presents the presence of a smooth surface, indicating the possibility of miscibility between the arrays. Therefore, the blending makes possible the fabrication of low-cost materials with applications in several areas. (author)

  12. A new conceptual reprocessing process based on the diamide derivate extraction

    International Nuclear Information System (INIS)

    Chen, Jing; Wang, Shuwei

    2005-01-01

    Several diamide derivates were synthesized in our laboratory. The extraction of actinides and some fission products by these compounds were studied. N,N,N'N'-tetra-(2-ethylhexyl)-3-oxa-pentanediamide (TEHOPDA) was proven to be a suitable extractant for actinides removal from nitric acid solution. The actinides can be stripped from the loaded solvent by the dilute nitric acid. TEHOPDA showed a high loading capacity to actinides and lanthanides with a mixture of n-octanol and kerosene as the diluent. Considering the effective-extraction and easy-stripping of actinides, 0.25mol/L TEHOPDA - 30% n-octanol + 70% kerosene was selected as the solvent. A cascade extraction experiment was carried out with the simulated dissolver solution of spend fuel as feed. 99.99% U and 99.999% Am, Pu, and Np were extracted in a 4-stage test. Based on the experimental results, a conceptual reprocessing process was proposed. (author)

  13. Measurement of velocity and velocity derivatives based on pattern tracking in 3D LIF images

    Energy Technology Data Exchange (ETDEWEB)

    Deusch, S.; Merava, H.; Rys, P. [Swiss Federal Inst. of Technol., Zurich (Switzerland). Dept. of Chem. Eng.; Dracos, T. [Swiss Federal Institute of Technology, Untergasse 14, 8126 Zumikon (Switzerland)

    2000-10-01

    Pattern tracking in consecutive 3D LIF images based on least squares matching (LSM) of grey levels has been developed recently for velocity and velocity gradient measurements. The shortcomings of this method are clearly shown. The present article presents an improvement on this method by introducing a local multi-patch (LMP) technique through the LSM approach. The method is validated using the flow field of a turbulent channel flow obtained by direct numerical simulation (DNS) and a synthetic image with grey-level patterns. The results show that LMP matching allows the determination of the velocity and the velocity gradient fields with high accuracy including the second derivatives. Measurements of a round non-buoyant jet are presented which demonstrate the good performance of the method when applied under laboratory conditions. This method can also be applied on two-dimensional images provided that the flow is strictly two-dimensional. (orig.)

  14. Measurement of velocity and velocity derivatives based on pattern tracking in 3D LIF images

    Science.gov (United States)

    Deusch, S.; Merava, H.; Dracos, T.; Rys, P.

    Pattern tracking in consecutive 3D LIF images based on least squares matching (LSM) of grey levels has been developed recently for velocity and velocity gradient measurements. The shortcomings of this method are clearly shown. The present article presents an improvement on this method by introducing a local multi-patch (LMP) technique through the LSM approach. The method is validated using the flow field of a turbulent channel flow obtained by direct numerical simulation (DNS) and a synthetic image with grey-level patterns. The results show that LMP matching allows the determination of the velocity and the velocity gradient fields with high accuracy including the second derivatives. Measurements of a round non-buoyant jet are presented which demonstrate the good performance of the method when applied under laboratory conditions. This method can also be applied on two-dimensional images provided that the flow is strictly two-dimensional.

  15. Synthesis and Biological Evaluation of Mannich Bases of Isoxazoline Derivatives as Novel Anti-Microbial Agents

    Directory of Open Access Journals (Sweden)

    Pawar Sudhir

    2012-01-01

    Full Text Available A novel series of compounds were synthesized by condensation reaction of substituted acetophenone (1a-b with substituted aldehyde (2a-b in presence of alcoholic sodium hydroxide to get intermediate chalcones (3a-c, which were further treated with hydroxylamine hydrochloride in presence of sodium hydroxide to get isoxazolines derivatives (4a-c. The latter were refluxed with substituted primary amines and formaldehyde for 6-10 h to afford Mannich bases. The synthesized compounds were characterized on the basis of their spectral (IR, 1HNMR data and evaluated for the antimicrobial activity by using Zone of Inhibition by cup plate method and Minimum Inhibitory Concentration by broth dilution method.

  16. AN EXPLORATION ON THE SYNTHESIS AND BIO-APPLICATIONS OF DERIVATIVES OF HETEROCYCLIC MANNICH BASES

    Directory of Open Access Journals (Sweden)

    P. S. Manjula

    2016-01-01

    Full Text Available The Mannich reaction is a three-component reaction of an aldehyde, a primary or secondary amine and a ketone which is one of the most powerful C-C bond forming reactions in organic synthesis. It leads to β-amino carbonyl compounds, which are useful for the syntheses of nitrogen containing compounds, such as natural products and medicinally relevant compounds. The versatility and potential of these compounds to introduce both functional and structural diversity using the Mannich reaction have stimulated the creativity of chemists. Keeping in view of the importance of this organic moiety in the field of medicine and biology here an attempt has been made to review the synthesis and biological importance of heterocyclic Mannich base derivatives.

  17. Smart photovoltaics based on dye-sensitized solar cells using photochromic spiropyran derivatives as photosensitizers

    International Nuclear Information System (INIS)

    Ma, Shengbo; Ting, Hungkit; Ma, Yingzhuang; Zheng, Lingling; Zhang, Miwei; Xiao, Lixin; Chen, Zhijian

    2015-01-01

    In this paper, smart photovoltaic (SPV) devices, integrating both functions of solar cells and smart windows, was fabricated based on dye-sensitized solar cells using photochromic spiropyran derivatives SIBT as photosensitizers. SPV devices have self-regulated power conversion efficiency (PCE) and light transmission responding to the incident spectra due to the photoisomerization of SIBT. SIBT isomerize from closed-ring form to open-ring form under UV illumination, accompanied with enhanced visible light absorption and electron delocalization. Therefore, increased PCE and absorption in SPV devices were observed under UV treatment and the devices can be restored gradually to the initial status when kept in dark. The SPV devices have self-regulation of PCE and sunlight transmission responding to the changing sun spectra in different times of a day, providing a proper energy usage and a better sun-shading

  18. Earth's gravity field modelling based on satellite accelerations derived from onboard GPS phase measurements

    Science.gov (United States)

    Guo, X.; Ditmar, P.; Zhao, Q.; Klees, R.; Farahani, H. H.

    2017-09-01

    GPS data collected by satellite gravity missions can be used for extracting the long-wavelength part of the Earth's gravity field. We propose a new data processing method which makes use of the `average acceleration' approach to gravity field modelling. In this method, satellite accelerations are directly derived from GPS carrier phase measurements with an epoch-differenced scheme. As a result, no ambiguity solutions are needed and the systematic errors that do not change much from epoch to epoch are largely eliminated. The GPS data collected by the Gravity Field and Steady-State Ocean Circulation Explorer (GOCE) satellite mission are used to demonstrate the added value of the proposed method. An analysis of the residual accelerations shows that accelerations derived in this way are more precise, with noise being reduced by about 20 and 5% at the cross-track component and the other two components, respectively, as compared to those based on kinematic orbits. The accelerations obtained in this way allow the recovery of the gravity field to a slightly higher maximum degree compared to the solution based on kinematic orbits. Furthermore, the gravity field solution has an overall better performance. Errors in spherical harmonic coefficients are smaller, especially at low degrees. The cumulative geoid height error is reduced by about 15 and 5% up to degree 50 and 150, respectively. An analysis in the spatial domain shows that large errors along the geomagnetic equator, which are caused by a high electron density coupled with large short-term variations, are substantially reduced. Finally, the new method allows for a better observation of mass transport signals. In particular, sufficiently realistic signatures of regional mass anomalies in North America and south-west Africa are obtained.

  19. sup(99m)Tc-DTPA gamma-camera renography: Normal values and rapid determination of single-kidney glomerular filtration rate

    International Nuclear Information System (INIS)

    Rehling, M.; Moller, M.L.; Lund, J.O.; Trap-Jensen, J.; Jensen, K.B.; Thamdrup, B.

    1985-01-01

    A method for sup(99m)Tc-diethylenetriaminepentaacetate (DTPA) gamma-camera renography is presented. From each renogram an uptake index (UI) proportional to the single-kidney glomerular filtration rate (SKGFR) is defined. If the proportionality factor between UI and SKGFR is the same in all patients, UI can be used as an accurate measure of SKGFR. In order to test this, sup(99m)Tc-DTPA renography was performed in 101 patients with glomerular filtration rates (GFR) varying between 4 and 172 ml/min. The sum of the right- and left-kidney UIs correlated well with the total GFR calculated from the simultaneously measured plasma clearance of sup(99m)Tc-DTPA after a single injection. The correlation coefficient was 0.97. The method was tested in a prospective study of 57 patients. The total GFR estimated from the renograms was not significantly different from the GFR calculated from the plasma clearance of sup(99m)Tc-DTPA. The coefficient of variation -a combination of inaccuracy and imprecision in the estimates as well as in the reference values - was 11.8% at a GFR of 100 ml/min. It is concluded that, in adults, the SKGFR can be calculated as part of the clinical routine from sup(99m)Tc-DTPA gamma-camera renography without determining the injected dose or collecting urine or blood samples. Normal values for some parameters of the renogram obtained in 25 normal subjects are given. (orig.)

  20. Detection of active bile leak with Gd-EOB-DTPA enhanced MR cholangiography: comparison of 20-25 min delayed and 60-180 min delayed images.

    Science.gov (United States)

    Cieszanowski, Andrzej; Stadnik, Anna; Lezak, Aleksandra; Maj, Edyta; Zieniewicz, Krzysztof; Rowinska-Berman, Katarzyna; Grudzinski, Ireneusz P; Krawczyk, Marek; Rowiński, Olgierd

    2013-12-01

    The purpose of this study was to assess the value of contrast-enhanced magnetic resonance cholangiography (MRC) performed in different time delays after injection of gadoxetic acid disodium (Gd-EOB-DTPA) for the diagnosis of active bile leak. This retrospective analysis included Gd-EOB-DTPA enhanced MR images of 34 patients suspected of bile leak. Images were acquired 20-25 min after Gd-EOB-DTPA injection. If there was inadequate contrast in the bile ducts then delayed images after 60-90 min and 150-180 min were obtained. Results were correlated with intraoperative findings, ERCP results, clinical data, laboratory tests, and follow-up examinations. Gd-EOB-DTPA enhanced MRC yielded an overall sensitivity of 96.4%, specificity of 100% and accuracy of 97.1% for the diagnosis of an active bile leak. The sensitivity of 20-25 min delayed MR images was 42.9%, of combined 20-25 min and 60-90 min delayed images was 92.9% and of combined 20-25 min, 60-90 min and 150-180 min delayed images was 96.4%. Gd-EOB-DTPA enhanced MRC utilizing delayed phase images was effective for detecting the presence and location of active bile leaks. The images acquired 60-180 min post-injection enabled identification of bile leaks even in patients with a dilated biliary system or moderate liver dysfunction. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  1. 64Cu-DOTATATE PET for Neuroendocrine Tumors: a Prospective Head-to-Head Comparison with 111In-DTPA-octreotide in 112 Patients

    DEFF Research Database (Denmark)

    Pfeifer, Andreas Klaus; Knigge, Ulrich; Binderup, Tina

    2015-01-01

    )Cu-DOTATATE than with (111)In-DTPA-OC. Moreover, in 40 of 112 cases (36%) lesions were detected by (64)Cu-DOTATATE in organs not identified as disease-involved by (111)In-DTPA-OC. CONCLUSION: With these results, we demonstrate that (64)Cu-DOTATATE is far superior to (111)In-DTPA-OC in diagnostic...... of discrepant imaging findings. The McNemar test was used to compare the diagnostic performance. RESULTS: Eighty-seven patients were congruently PET- and SPECT-positive. No SPECT-positive cases were PET-negative, whereas 10 false-negative SPECT cases were identified using PET. The diagnostic sensitivity...... and accuracy of (64)Cu-DOTATATE (97% for both) were significantly better than those of (111)In-DTPA-OC (87% and 88%, respectively, P = 0.017). In 84 patients (75%), (64)Cu-DOTATATE identified more lesions than (111)In-DTPA-OC and always at least as many. In total, twice as many lesions were detected with (64...

  2. Tc-99m DTPA and Tc-99m DMSA renal scan findings in patients with congenital megacalyces and megaureter without urinary tract obstruction

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Byeong Cheol; Bae, Jin Ho; Jeong, Sin Young; Lee, Jae Tae; Lee, Kyu Bo [Kyungpook National University Medical School, Daegu (Korea, Republic of)

    2003-06-01

    A 10 days old male infant with congenital megacalyces and megaureter, diagnosed by prenatal ultrasonographic screening, underwent Tc-99m DTPA renal scan for evaluation of urinary tract patency, Tc-99m DMSA scan for evaluation of renal cortical damage. He also underwent intravenous urography(IVU) and renal ultrasonography. Tc-99m DTPA renal scan demonstrates intense tracer accumulation in enlarged both renal pelvocalyses and ureters, which rapidly washout diuretics administration. Tc-99m DMSA renal cortical scan shows no remarkable photon defect in both renal cortices and visible tracer uptake in both megaureter areas. Ultasonographic and IVU studies show enlarged both renal calyses and bullously dilated ureters, but no dilatation in renal pelvis. Follow up Tc-99m DTPA renal scan, performed at one year later, also reveals intense tracer accumulation in enlarged both urinary tracts which rapidly washout without diuretics, and shows no significant change compare to the previous Tc-99m DTPA renal scan. Urinary tract obstruction and renal cortical damage can be easily evaluated with Tc-99m DTPA and Tc-99m DMSA scans in patients with megacalyces and megaureter.

  3. Usefulness of {sup 99m}Tc-DTPA renography and diuretic renography in predicting successful stone discharge following outpatient ESWL in patients with a single ureteral stone

    Energy Technology Data Exchange (ETDEWEB)

    Soga, Norihito; Komeda, Yoshinori [Yokkaichi Health Insurance Hospital, Mie (Japan); Suzuki, Ryuichi; Kawamura, Juichi

    1996-11-01

    We analyzed the {sup 99m}Tc-DTPA renogram with and without diuresis to predict the possibility of stone discharge on the outpatient basis by renogram patterns. Between October 1993 and December 1995, {sup 99m}Tc-DTPA renography was performed in 79 patients with a single ureteral stone. The {sup 99m}Tc-DTPA renogram pattern was classified into the three types of normal function, obstruction and lower function patterns and the complete stone discharge rate was 93, 63 and 25%, respectively. In addition, diuretic renography using Furosemide was performed in patients with an obstruction pattern and the three renogram patterns of return to the normal curve, a diuretic response and no response were obtained; the complete stone discharge rate was 44, 65.3 and 93%, respectively. From this study, patients with a single ureteral stone with a normal pattern on the regular DTPA renogram and patients with no response pattern on the diuretic renogram, even if in such patients an obstructive pattern was seen on the regular DTPA renogram, seem to be a good candidate for obtaining a high rate of a stone discharge with extracorporeal shock wave lithotripsy (ESWL) treatment in the outpatients basis. (author)

  4. Comparison of renal clearance of 99mTc-DTPA and inulin 131I-hippurate and PAH as well as creatinine clearance in Wistar-rats

    International Nuclear Information System (INIS)

    Hagemann, J.; Li Min Su; Strangfeld, D.; Schuerer, M.; Siewert, H.; Pietsch, R.; Kruse, I.; Priem, F.

    1988-01-01

    Averages and standard deviations of 99m Tc-DTPA and 131 I-hippurate slope clearance were consecutively determined for 56 male Wistar rats, with a body-weight of 271 ± 69 g in a single investigation. Clearance of 99m Tc-DTPA was 17.4 ± 3.4, that of 131 I-hippurate was 34.3 ± 7.2 μl · s -1 per 100 g body weight. For 17 rats inulin and PAH clearances were determined after 3 days with the steady-state method with continuous infusion and 3-4 periods of urine collection. During the same periods endogeneous creatinine clearance was determined. 99m Tc-DTPA slope clearance correlated well with inulin clearance, also the hippurate with the PAH clearance. The high values of the filtration fraction, calculated from radioisotope and chemical methods, and the low PAH extraction of 42% lead to the conclusion, that PAH and hippurate are incompletely eliminated by the rat kidney from plasma and therefore are inadequate for determining renal blood flow in rats. Creatinine clearance was 4.7 ± 1.38 μl · s -1 per 100 g body weight, much lower than that of inulin and 99m Tc-DTPA. Therefore is assumed, that tubular reabsorption of creatinine occurs and creatinine clearance cannot serve for the evaluation of GFR in rats. For this, however, the clearance of 99m Tc-DTPA seems well applicable in Wistar rats. (author)

  5. Development of risk-based computer models for deriving criteria on residual radioactivity and recycling

    International Nuclear Information System (INIS)

    Chen, S.Y.

    1994-01-01

    Argonne National Laboratory (ANL) is developing multimedia environmental pathway and health risk computer models to assess radiological risks to human health and to derive cleanup guidelines for environmental restoration, decommissioning, and recycling activities. These models are based on the existing RESRAD code, although each has a separate design and serves different objectives. Two such codes are RESRAD-BUILD and RESRAD-PROBABILISTIC. The RESRAD code was originally developed to implement the US Department of Energy's (DOE's) residual radioactive materials guidelines for contaminated soils. RESRAD has been successfully used by DOE and its contractors to assess health risks and develop cleanup criteria for several sites selected for cleanup or restoration programs. RESRAD-BUILD analyzes human health risks from radioactive releases during decommissioning or rehabilitation of contaminated buildings. Risks to workers are assessed for dismantling activities; risks to the public are assessed for occupancy. RESRAD-BUILD is based on a room compartmental model analyzing the effects on room air quality of contaminant emission and resuspension (as well as radon emanation), the external radiation pathway, and other exposure pathways. RESRAD-PROBABILISTIC, currently under development, is intended to perform uncertainty analysis for RESRAD by using the Monte Carlo approach based on the Latin-Hypercube sampling scheme. The codes being developed at ANL are tailored to meet a specific objective of human health risk assessment and require specific parameter definition and data gathering. The combined capabilities of these codes satisfy various risk assessment requirements in environmental restoration and remediation activities

  6. Development of risk-based computer models for deriving criteria on residual radioactivity and recycling

    International Nuclear Information System (INIS)

    Chen, Shih-Yew

    1995-01-01

    Argonne National Laboratory (ANL) is developing multimedia environmental pathway and health risk computer models to assess radiological risks to human health and to derive cleanup guidelines for environmental restoration, decommissioning, and recycling activities. These models are based on the existing RESRAD code, although each has a separate design and serves different objectives. Two such codes are RESRAD-BUILD and RESRAD-PROBABILISTIC. The RESRAD code was originally developed to implement the U.S. Department of Energy's (DOE's) residual radioactive materials guidelines for contaminated soils. RESRAD has been successfully used by DOE and its contractors to assess health risks and develop cleanup criteria for several sites selected for cleanup or restoration programs. RESRAD-BUILD analyzes human health risks from radioactive releases during decommissioning or rehabilitation of contaminated buildings. Risks to workers are assessed for dismantling activities; risks to the public are assessed for occupancy. RESRAD-BUILD is based on a room compartmental model analyzing the effects on room air quality of contaminant emission and resuspension (as well as radon emanation), the external radiation pathway, and other exposure pathways. RESRAD-PROBABILISTIC, currently under development, is intended to perform uncertainty analysis for RESRAD by using the Monte Carlo approach based on the Latin-Hypercube sampling scheme. The codes being developed at ANL are tailored to meet a specific objective of human health risk assessment and require specific parameter definition and data gathering. The combined capabilities of these codes satisfy various risk assessment requirements in environmental restoration and remediation activities. (author)

  7. Deriving pathway maps from automated text analysis using a grammar-based approach.

    Science.gov (United States)

    Olsson, Björn; Gawronska, Barbara; Erlendsson, Björn

    2006-04-01

    We demonstrate how automated text analysis can be used to support the large-scale analysis of metabolic and regulatory pathways by deriving pathway maps from textual descriptions found in the scientific literature. The main assumption is that correct syntactic analysis combined with domain-specific heuristics provides a good basis for relation extraction. Our method uses an algorithm that searches through the syntactic trees produced by a parser based on a Referent Grammar formalism, identifies relations mentioned in the sentence, and classifies them with respect to their semantic class and epistemic status (facts, counterfactuals, hypotheses). The semantic categories used in the classification are based on the relation set used in KEGG (Kyoto Encyclopedia of Genes and Genomes), so that pathway maps using KEGG notation can be automatically generated. We present the current version of the relation extraction algorithm and an evaluation based on a corpus of abstracts obtained from PubMed. The results indicate that the method is able to combine a reasonable coverage with high accuracy. We found that 61% of all sentences were parsed, and 97% of the parse trees were judged to be correct. The extraction algorithm was tested on a sample of 300 parse trees and was found to produce correct extractions in 90.5% of the cases.

  8. Recent progress in electrochemical biosensors based on phenylboronic acid and derivatives.

    Science.gov (United States)

    Anzai, Jun-Ichi

    2016-10-01

    This review provides an overview of recent progress made in the development of electrochemical biosensors based on phenylboronic acid (PBA) and its derivatives. PBAs are known to selectively bind 1,2- and 1,3-diols to form negatively charged boronate esters in neutral aqueous media and have been used to construct electrochemical glucose sensors because of this selective binding. PBA-modified metal and carbon electrodes have been widely studied as voltammetric and potentiometric glucose sensors. In some cases, ferroceneboronic acid or ferrocene-modified phenylboronic acids are used as sugar-selective redox compounds. Another option for sensors using PBA-modified electrodes is potentiometric detection, in which the changes in surface potential of the electrodes are detected as an output signal. An ion-sensitive field effect transistor (FET) has been used as a signal transducer in potentiometric sensors. Glycoproteins, such as glycated hemoglobin (HbA1c), avidin, and serum albumin can also be detected by PBA-modified electrodes because they contain hydrocarbon chains on the surface. HbA1c sensors are promising alternatives to enzyme-based glucose sensors for monitoring blood glucose levels over the preceding 2-3months. In addition, PBA-modified electrodes can be used to detect a variety of compounds including hydroxy acids and fluoride (F(-)) ions. PBA-based F(-) ion sensors may be useful if reagentless sensors can be developed. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. Design of Optimal Proportional Integral Derivative Based Power System Stabilizer Using Bat Algorithm

    Directory of Open Access Journals (Sweden)

    Dhanesh K. Sambariya

    2016-01-01

    Full Text Available The design of a proportional, derivative, and integral (PID based power system stabilizer (PSS is carried out using the bat algorithm (BA. The design of proposed PID controller is considered with an objective function based on square error minimization to enhance the small signal stability of nonlinear power system for a wide range of operating conditions. Three benchmark power system models as single-machine infinite-bus (SMIB power system, two-area four-machine ten-bus power system, and IEEE New England ten-machine thirty-nine-bus power system are considered to examine the effectiveness of the designed controller. The BA optimized PID based PSS (BA-PID-PSS controller is applied to these benchmark systems, and the performance is compared with controllers reported in literature. The robustness is tested by considering eight plant conditions of each system, representing the wide range of operating conditions. It includes unlike loading conditions and system configurations to establish the superior performance with BA-PID-PSS over-the-counter controllers.

  10. Water-pipe smoking effects on pulmonary permeability using technetium-99m DTPA inhalation scintigraphy

    International Nuclear Information System (INIS)

    Aydin, A.; Durak, H.; Ucan, E.S.; Kaya, G.C.; Ceylan, E.; Kiter, G.

    2004-01-01

    Although extensive work has been done on cigarette smoking and its effects on pulmonary function, there are limited number of studies on water-pipe smoking. The effects of water-pipe smoking on health are not widely investigated. The aim of this study was to determine the effects of water-pipe smoking on pulmonary permeability. Technetium-99m DTPA inhalation scintigraphy was performed on 14 water-pipe smoker volunteers (all men, mean age 53.7±9.8) and 11 passive smoker volunteers (1 woman, 10 men, mean age 43.8±12). Clearance half-time (T 1/2) was calculated by placing a monoexponential fit on the time activity curves. Penetration index (PI) of the radioaerosol was also calculated. PI was 0.58±0.14 and 0.50±0.12 for water-pipe smokers (WPS) and passive smokers (PS) respectively. T 1/2 of peripheral lung was 57.3±12.7 and 64.6±13.2 min, central airways was 55.8±23.5 and 80.1±35.2 min for WPS and PS, respectively (p≤0.05). Forced expiratory volume in one second/forced vital capacity (FEV 1 /FVC)% was 82.1±8.5 (%) and 87.7±6.5 (%) for WPS and PS, respectively (0.025< p≤0.05). We suggest that water-pipe smoking effects pulmonary epithelial permeability more than passive smoking. Increased central mucociliary clearance in water-pipe smoking may be due to preserved humidity of the airway tracts. (author)

  11. Detectability of hepatocellular carcinoma: comparison of Gd-DTPA-enhanced and SPIO-enhanced MR imaging

    International Nuclear Information System (INIS)

    Kwak, Hyo Sung; Lee, Jeong Min; Kim In Hwan; Kim, Chong Soo; Han, Hyeun Young; Yoon, Kwon ha; Shin, Kyung Sook

    2000-01-01

    To compare the detectability of hepatocellular carcinoma (HCC) using superparamagnetic iron oxide (SPIO)-enhanced T2-weighted turbo spin echo (TSE), SPIO-enhanced T2-weighted FISP, and dynamic Gd-DTPA-enhanced fast low-angle shot (FLASH) MR images. In order to assess their hepatic lesions, 25 patients (20 men and 5 women) with HCC were enrolled in an MR study in which both gadolinium and Spiro were used. Since the lesions were most conspicuous during the phase of dynamic arterial dominant phase of dynamic gadolinium-enhanced imaging, this was the phase used for analysis. Images were analyzed qualitatively and quantitatively, and to compare the diagnostic value of gadolinium-enhanced imaging with that of SPIO-enhanced imaging for the detection of HCCs, a receiver-operated characteristic curve was obtained. Qualitative analysis revealed a significantly higher percentage of signal loss and a higher liver-lesion contrast-to-noise ratio on SPIO-enhanced FISP imaging than on SPIO-enhanced T2-weighted TSE imaging (p less than 0.05). It also showed that the lesions were most clearly visible on SPIO-enhanced FISP imaging (and significantly so), followed by SPIO-enhanced T2-weighted TSE imaging, and dynamic gadolinium-enhanced imaging. Imaging artifacts were more prominent on SPIO-enhanced T2-weighted TSE than on SPIO-enhanced PISF imaging or dynamic gadolinium-enhanced imaging (p less than 0.05). According to ROC analysis, SPIO-enhanced T2-weighted turbo spin echo (TSE) or SPIO-enhanced FISP imaging achieved higher accuracy than did dynamic gadolinium-enhanced FLASH imaging (p less than 0.05). For the detection of hepatocellular carcinomas, SPIO-enhanced MR imaging is better than gadolinium-enhanced FLASH imaging

  12. Assessment of viability of acute myocardial infarction using MRI and gadolinium DTPA

    International Nuclear Information System (INIS)

    Toyama, Takuji; Nishimura, Tsunehiko; Yamada, Naoaki

    1993-01-01

    To evaluate the myocardial viability using gated MRI and gadolinium-DTPA enhancement, we compared with Tl-201 exercise myocardial scintigraphy (Ex-Tl) and two-dimensional echocardiography (UCG) in 22 patients with acute myocardial infarction (AMI). These patients were divided into three groups. In group A (8 patients), thallium redistribution (RD) was found at infarcted region. In group B (6 patients), RD was not found at infarcted region, but wall motion by UCG was normal or hypokinesis at infarcted region. In group C (8 patients), RD was not found at infarcted region, and wall motion by UCG was akinesis or dyskinesis at infarcted region. MRI was performed at one week, two weeks, one month and three months from the onset of AMI. We evaluated signal intensity (SI), extent of Gd-E and wall thinning at short axial image of T 1 weighted image. Ex-T l was performed at one month after AMI to evaluate presence of RD and extent of perfusion defect on delayed SPECT image. In addition, UCG was performed within one month after AMI to evaluate regional wall motion at infarcted region. In most cases of groups A and B Gd-E>PD was found. Decrease of Gd-E area was found in group A, but early disappearance of Gd-E within three months was not different among three groups. This study indicated that Gd-E>PD and decrease of Gd-E area reflected myocardial viability at infarcted region to some extent, but SI of Gd-E and early disappearance of Gd-E did not reflect myocardial viability. Gd-E was slightly useful for detecting the myocardial viability of acute myocardial infarction. (author)

  13. Diagnosis und differential diagnosis of focal liver lesions using the hepatocyte-specific contrast agent Gd-EOB-DTPA; Diagnose und Differenzialdiagnose fokaler Leberlaesionen unter Verwendung von Gd-EOB-DTPA (Primovist)

    Energy Technology Data Exchange (ETDEWEB)

    Ringe, Kristina Imeen [Medizinische Hochschule Hannover (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie

    2016-03-15

    The implementation of MR contrast agents significantly improves detection and characterization of focal liver lesions. This article is focusing on the hepatocyte-specific contrast agent Gd-EOB-DTPA, which has been available in Germany for liver MRI since 2004. In the introduction, the specific pharmacokinetic and -dynamic properties of this contrast agent are reviewed, and a workflow-optimized pulse sequence protocol for comprehensive hepatobiliary MRI in daily routine is presented. Afterwards, the appearance of the most common focal liver lesions is illustrated, including the differences to the use of extracellular contrast agents as well as a discussion of the most important differential diagnoses.

  14. First experiences with application of gadolinium-DTPA in infants and small children under two years of age. Erste Erfahrungen beim Einsatz von Gadolinium-DTPA bei Saeuglingen und Kleinkindern unter zwei Jahren

    Energy Technology Data Exchange (ETDEWEB)

    Maas, R.; Lausch, N.; Buecheler, E. (Hamburg Univ. (Germany). Radiologische Klinik); Grzyska, U. (Hamburg Univ. (Germany). Neurologische Klinik)

    1991-07-01

    The use of Gadolinium-DTPA as a paramagnetic contrast agent in MRI with adults and juveniles concerning brain and spinal cord pathology is well proven since years. In the FRG it is only introduced for children over two years of age. Therefore this report deales with the experience in four infants and small children under the age of two. They all were suffering from neurological tumors and got additional diagnostic information in three cases. Clinical side-effects like urticaria, vomiting or convulsions had not been observed nor had pathologic changes of the biochemical parameters been noticed. (orig./GDG).

  15. HIGHLY PRECISE APPROXIMATION OF FREE SURFACE GREEN FUNCTION AND ITS HIGH ORDER DERIVATIVES BASED ON REFINED SUBDOMAINS

    Directory of Open Access Journals (Sweden)

    Jiameng Wu

    2018-01-01

    Full Text Available The infinite depth free surface Green function (GF and its high order derivatives for diffraction and radiation of water waves are considered. Especially second order derivatives are essential requirements in high-order panel method. In this paper, concerning the classical representation, composed of a semi-infinite integral involving a Bessel function and a Cauchy singularity, not only the GF and its first order derivatives but also second order derivatives are derived from four kinds of analytical series expansion and refined division of whole calculation domain. The approximations of special functions, particularly the hypergeometric function and the algorithmic applicability with different subdomains are implemented. As a result, the computation accuracy can reach 10-9 in whole domain compared with conventional methods based on direct numerical integration. Furthermore, numerical efficiency is almost equivalent to that with the classical method.

  16. Exercise induced renal dysfunction demonstrated both in hypertensives and normotensive controls studies by Tc-99m-DTPA

    International Nuclear Information System (INIS)

    Mizuiri, S.; Hayashi, I.; Ohara, T.; Hirata, K.; Sasaki, Y.

    1985-01-01

    It was previously reported that the hippurate transport disturbance after exercise is a specific phenomenon to patients with hypertension. The authors' study with Tc-99m-DTPA revealed exercise induced renal dysfunction not only in hypertensives (H) but also in normotensive controls (N). The details of the investigation is presented. Tc-99m-DTPA was intravenously injected at rest and during bicycle ergometric stress to 14 H and 14 N in sitting position. Serial dynamic renal images were taken, of which data were simultaneously stored in a data processor for later analysis. The renogram was drawn setting ROI on each kidney. Peak counts (PC) of vascular phase, peak time (PT) of secretory phase and radioisotope retention rate (RR) at 10 minutes were the parameters being compared between at rest and at exercise. GFR of each kidney was determined. Blood samples were obtained at rest and at the end of exercise for the measurement of aldosterone (ALD), plasma renin activity (PRA) and catecholamines (A, NA). Exercise caused significant lowering of PC, prolongation of PT and increase in RR (10 min. counts/peak counts) both in H and N. GFR (miota/min.) during exercise was significantly lower than at rest in both H (80 +- 22 vs 93.8 +- 16.9, p<0.02) and N (84 +- 17 vs 102 +- 15, p<0.01). ALD, PRA, A and NA are all elevated during exercise both in H and N. None of the rest-exercise differences significantly differed between H and N. The data indicate the exercise induced renal dysfunction demonstrated by Tc-99m-DTPA renograms is not specified to H but can also be observed in N, which may be resulted from the common changes in H and N of GFR and humoral factors

  17. Quantitative evaluation of separate kidney function and dynamic renal imaging with sup(99m) Tc-DTPA

    International Nuclear Information System (INIS)

    Seto, Hikaru

    1979-01-01

    A new method of quantitative evaluation of separate kidney function and dynamic renal imaging, using sup(99m) Tc-diethylenetriaminepentaacetic acid (sup(99m) Tc-DTPA) and a scintillation camera interfaced to a computer and its clinical applications are described. Normal values of separate kidney clearance are measured on 6 normal subjects. Left kidney: 59.0 +- 11.3 ml/min, right kidney: 55.1 +- 5.7 ml/min, total kidney: 114.1 +- 16.2 ml/min. This value corresponds well to the normal value of gromerular filtration rate (GFR) measured with sodium thiosulfate. Relative separate renal perfusion function ratios are correlated well with 131 I-hippuran (r = 0.974). Normal values in 42 subjects are as follows; left kidney: 52.2 +- 2.5%, right kidney: 47.8 +- 2.5%. Separate kidney function ratios are correlated well with sup(99m) Tc-DTPA clearance and GFR. Correlation coefficients are 0.977 (n-13), 0.937 (n-112), respectively. Separate kidney function ratios of the diseased kidneys are significantly decreased (p < 0.01) in comparison with normal kidneys. Separate kidney excretion ratios of the diseased kidneys of unilateral renal disease and bilateral moderate to severe renal disease reveal significant increase (P < 0.01) in comparison with normal kidneys. Sensitivity to detect renal space occupying lesions with sup(99m) Tc-DTPA dynamic images in 95.0% (38 in 40 cases), which is superior to sup(99m) Tc-dimercaptosuccinic acid static images (87.5%). (author)

  18. [Scintigraphy of pulmonary ventilation with 99mTc-DTPA radio-aerosol. I. Semiotics of the static images].

    Science.gov (United States)

    Maini, C L; Bonetti, M G; Giordano, A; Pistelli, R; Antonelli Incalzi, R; Vecchioli, A; Galli, G

    1986-04-01

    Papers on deposition pattern analyses of radio-aerosol lung scans are few and not easy to interpret as there is a general lack of technical standardization and the number of patients studied is not large. Moreover these reports have been generally obtained with non-hydrosoluble radioaerosols. In the present study 43 patients underwent conventional pulmonary function testing and lung scanning using small droplet (equal or less than 2 microns) polydisperse 99mTc-DTPA radioaerosol produced with the "Settling Bag System"--Medi 400 (Sorin). The scans were analysed by two methods: a semiquantitative method proposed by Taplin (SQT); an original simpler semiquantitative method (SQM). Correlations of SQT and SQM with FEV1 and MEF75 resulted highly significant (p less than 0,001). SQM proved to be superior to SQT as far as reproducibility is concerned. The following conclusions can be drawn: small particle 99mTc-DTPA aerosol can be easily and cheaply produced by a commercial device; such a radioaerosol is well suited for the evaluation of small and large airways patency, as reflected by MEF75 and FEV1 respectively, with a diagnostic yield comparable to non-hydrosoluble radioaerosols; the original semiquantitative description of the deposition patterns proposed and validated in this study is quite easy to implement and it yields a high correlation with pulmonary function tests; moreover such an approach does not require digital data processing; the sensitivity of 99mTc-DTPA for the diagnosis of bronchial obstruction is very high and superior to routine pulmonary function tests; in addition the ventilation scan allows the topographical localization of the obstructions themselves.

  19. Large-scale derived flood frequency analysis based on continuous simulation

    Science.gov (United States)

    Dung Nguyen, Viet; Hundecha, Yeshewatesfa; Guse, Björn; Vorogushyn, Sergiy; Merz, Bruno

    2016-04-01

    There is an increasing need for spatially consistent flood risk assessments at the regional scale (several 100.000 km2), in particular in the insurance industry and for national risk reduction strategies. However, most large-scale flood risk assessments are composed of smaller-scale assessments and show spatial inconsistencies. To overcome this deficit, a large-scale flood model composed of a weather generator and catchments models was developed reflecting the spatially inherent heterogeneity. The weather generator is a multisite and multivariate stochastic model capable of generating synthetic meteorological fields (precipitation, temperature, etc.) at daily resolution for the regional scale. These fields respect the observed autocorrelation, spatial correlation and co-variance between the variables. They are used as input into catchment models. A long-term simulation of this combined system enables to derive very long discharge series at many catchment locations serving as a basic for spatially consistent flood risk estimates at the regional scale. This combined model was set up and validated for major river catchments in Germany. The weather generator was trained by 53-year observation data at 528 stations covering not only the complete Germany but also parts of France, Switzerland, Czech Republic and Australia with the aggregated spatial scale of 443,931 km2. 10.000 years of daily meteorological fields for the study area were generated. Likewise, rainfall-runoff simulations with SWIM were performed for the entire Elbe, Rhine, Weser, Donau and Ems catchments. The validation results illustrate a good performance of the combined system, as the simulated flood magnitudes and frequencies agree well with the observed flood data. Based on continuous simulation this model chain is then used to estimate flood quantiles for the whole Germany including upstream headwater catchments in neighbouring countries. This continuous large scale approach overcomes the several

  20. Catalytic wet air oxidation of 2-chlorophenol over sewage sludge-derived carbon-based catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Tu, Yuting [Institut de recherches sur la catalyse et l’environnement de Lyon (IRCELYON), CNRS – Université Claude Bernard Lyon 1, 2 Avenue Albert Einstein, 69626 Villeurbanne Cedex (France); School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275 (China); Xiong, Ya; Tian, Shuanghong [School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275 (China); Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Guangzhou 510275 (China); Kong, Lingjun [School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275 (China); Descorme, Claude, E-mail: claude.descorme@ircelyon.univ-lyon1.fr [Institut de recherches sur la catalyse et l’environnement de Lyon (IRCELYON), CNRS – Université Claude Bernard Lyon 1, 2 Avenue Albert Einstein, 69626 Villeurbanne Cedex (France)

    2014-07-15

    Highlights: • A sewage sludge derived carbon-supported iron oxide catalyst (FeSC) was prepared. • FeSC exhibited high catalytic activity in the wet air oxidation of 2-chlorophenol. • A strong correlation was observed between the 2-CP conversion, the iron leaching and the pH. • Using an acetate buffer, the iron leaching was suppressed while keeping some catalytic activity. • A simplified reaction pathway was proposed for the CWAO of 2-CP over the FeSC catalyst. - Abstract: A sewage sludge derived carbon-supported iron oxide catalyst (FeSC) was prepared and used in the Catalytic Wet Air Oxidation (CWAO) of 2-chlorophenol (2-CP). The catalysts were characterized in terms of elemental composition, surface area, pH{sub PZC}, XRD and SEM. The performances of the FeSC catalyst in the CWAO of 2-CP was assessed in a batch reactor operated at 120 °C under 0.9 MPa oxygen partial pressure. Complete decomposition of 2-CP was achieved within 5 h and 90% Total Organic Carbon (TOC) was removed after 24 h of reaction. Quite a straight correlation was observed between the 2-CP conversion, the amount of iron leached in solution and the pH of the reaction mixture at a given reaction time, indicating a strong predominance of the homogeneous catalysis contribution. The iron leaching could be efficiently prevented when the pH of the solution was maintained at values higher than 4.5, while the catalytic activity was only slightly reduced. Upon four successive batch CWAO experiments, using the same FeSC catalyst recovered by filtration after pH adjustment, only a very minor catalyst deactivation was observed. Finally, based on all the identified intermediates, a simplified reaction pathway was proposed for the CWAO of 2-CP over the FeSC catalyst.

  1. Assessment of vascularity and permeability in brain tumor using SPECT and [sup 99m]Tc-DTPA-human serum albumin in relation to [sup 201]Tl SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Nakagawara, Jyoji; Fukuoka, Seiji; Takahashi, Shuhei; Takahashi, Masaaki; Satoh, Katsuyasu; Suematsu, Katsumi; Nakamura, Jun-ichi (Nakamura Memorial Hospital, Sapporo (Japan))

    1994-02-01

    Single photon emission computed tomography (SPECT) using technetium-99m-DTPA-human serum albumin ([sup 99m]Tc-HSA-D) and thallium-201 chloride ([sup 201]Tl) was simultaneously performed on 25 patients with brain tumors; 10 with brain metastasis, 8 with astrocytoma (Gr. 3) and 7 with meningioma. The early image was obtained 10 minutes after [sup 99m]Tc-HSA-D (740 MBq) injection, and the delayed image was taken 5 hours after the injection. HSA-D index, based on the ratio of [sup 99m]Tc-HSA-D uptake in the tumor versus the cortical area, was calculated on each image, and compared with Tl index (tumor/contralateral cerebrum ratio). HSA-D delayed index was significantly greater than HSA-D early index in all tumor types (p<0.05 by the Wilcoxon ranked sign test). Linear correlation between HSA-D early index and HSA-D delayed index was significant in astrocytoma (GR. 3) (p<0.01) and meningioma (p<0.001), and a linear correlation between HSA-D delayed index and Tl index was significant in astrocytoma (Gr. 3) (p<0.05). It is concluded that HSA-D early index and delayed index could reflect tumor vascularity and permeability, respectively, and provide supplementary information for Tl index. (author).

  2. Synthesis, Radiolabelling and In Vitro Characterization of the Gallium-68-, Yttrium-90- and Lutetium-177-Labelled PSMA Ligand, CHX-A''-DTPA-DUPA-Pep

    Directory of Open Access Journals (Sweden)

    Benjamin Baur

    2014-04-01

    Full Text Available Since prostate-specific membrane antigen (PSMA has been identified as a diagnostic target for prostate cancer, many urea-based small PSMA-targeting molecules were developed. First, the clinical application of these Ga-68 labelled compounds in positron emission tomography (PET showed their diagnostic potential. Besides, the therapy of prostate cancer is a demanding field, and the use of radiometals with PSMA bearing ligands is a valid approach. In this work, we describe the synthesis of a new PSMA ligand, CHX-A''-DTPA-DUPA-Pep, the subsequent labelling with Ga-68, Lu-177 and Y-90 and the first in vitro characterization. In cell investigations with PSMA-positive LNCaP C4-2 cells, KD values of ≤14.67 ± 1.95 nM were determined, indicating high biological activities towards PSMA. Radiosyntheses with Ga-68, Lu-177 and Y-90 were developed under mild reaction conditions (room temperature, moderate pH of 5.5 and 7.4, respectively and resulted in nearly quantitative radiochemical yields within 5 min.

  3. Successful DTPA therapy in the case of 239Pu penetration via injured skin exposed to nitric acid

    International Nuclear Information System (INIS)

    Khokhryakov, V.F.; Belyaev, A.P.; Kidryavtseva, T.I.; Schadilov, A.E.; Moroz, G.S.; Shalaginov, V.A.

    2003-01-01

    This paper presents results of the radiological study and DTPA therapy for a worker exposed to a plutonium nitrate solution. Plutonium levels were measured in excreta, blood, plasma and wound for several weeks. Plutonium renal clearance ranged from 110-190 ml min -1 to 3-4 ml min -1 at different stages of chelation therapy. Plutonium absorption into blood from the injured skin amounted to 4.3%. As a result of intensive therapy, 96% of absorbed plutonium was successfully excreted. (author)

  4. Measurement of the arterial concentration of Gd-DTPA using MRI: a step toward quantitative perfusion imaging

    DEFF Research Database (Denmark)

    Fritz-Hansen, T; Rostrup, Egill; Larsson, H B

    1996-01-01

    A noninvasive method using an inversion recovery turbo-FLASH for dynamic measurement of the arterial input function represented by the bolus passage of Gd-DTPA in the descending aorta is presented, and the results are compared with the input function obtained by arterial blood samples. A good...... accordance between the two input functions was found, indicating that it is possible to measure the input function to the myocardium using MRI. A variation between the two concentration curves of 5% at upslope, 2.7% at peak point, and ... inversion time peak concentration....

  5. Determination of kidney function with 99mTc-DTPA renography using a dual-head camera

    DEFF Research Database (Denmark)

    Madsen, Claus J; Møller, Michael L; Zerahn, Bo

    2013-01-01

    Single-head gamma camera renography has been used for decades to estimate kidney function. An estimate of the glomerular filtration rate (GFR) can be obtained using Tc-diethylenetriaminepentaacetic acid (Tc-DTPA). However, because of differing attenuation, an error is introduced when the kidney...... depth or kidney size is unequal. This error can be reduced using geometric mean data obtained from dual-head renography. The aim of this study was to compare single-head versus dual-head assessment of single kidney function....

  6. Biological action of 239Pu during its administration to rats by inhalation and Zn- or CaDTPA- complexone therapy

    International Nuclear Information System (INIS)

    Sinyakov, E.G.; Nifatov, A.P.; Lyubchanskij, Eh.R.; Bazhin, A.G.

    1988-01-01

    The authors described the effect of substantial amounts of plutonium nitrate administered to rats by inhalation in the presence of Zn- or CaDTPA-complexone therapy for 2 months. A 2-fold decrease of absorbed doses in the lung, a 3-fold decrease in the skeleton and a 4-fold decrease in the liver were shown. The mean life span of the treated animals was considerably raised. A significant reduction of the frequency of development of severe pneumosclerosis and an increase in the frequency of lung tumor development were noted. In view of the above, complexone therapy should be necessarily recommended during inhalation of radionucleides in austantial ammounts

  7. Metabolomics-Based Elucidation of Active Metabolic Pathways in Erythrocytes and HSC-Derived Reticulocytes.

    Science.gov (United States)

    Srivastava, Anubhav; Evans, Krystal J; Sexton, Anna E; Schofield, Louis; Creek, Darren J

    2017-04-07

    A detailed analysis of the metabolic state of human-stem-cell-derived erythrocytes allowed us to characterize the existence of active metabolic pathways in younger reticulocytes and compare them to mature erythrocytes. Using high-resolution LC-MS-based untargeted metabolomics, we found that reticulocytes had a comparatively much richer repertoire of metabolites, which spanned a range of metabolite classes. An untargeted metabolomics analysis using stable-isotope-labeled glucose showed that only glycolysis and the pentose phosphate pathway actively contributed to the biosynthesis of metabolites in erythrocytes, and these pathways were upregulated in reticulocytes. Most metabolite species found to be enriched in reticulocytes were residual pools of metabolites produced by earlier erythropoietic processes, and their systematic depletion in mature erythrocytes aligns with the simplification process, which is also seen at the cellular and the structural level. Our work shows that high-resolution LC-MS-based untargeted metabolomics provides a global coverage of the biochemical species that are present in erythrocytes. However, the incorporation of stable isotope labeling provides a more accurate description of the active metabolic processes that occur in each developmental stage. To our knowledge, this is the first detailed characterization of the active metabolic pathways of the erythroid lineage, and it provides a rich database for understanding the physiology of the maturation of reticulocytes into mature erythrocytes.

  8. Synthesis, characterization, electrical and catalytic studies of some coordination compounds derived from unsymmetrical Schiff base ligand

    Directory of Open Access Journals (Sweden)

    G. B. Pethe

    2015-10-01

    Full Text Available New unsymmetrical tetradentate Schiff base ligand derived from 5-chloro-2-hydroxyacetophenone, 2-hydroxy-5-methyl-3-nitro acetophenone and carbohydrazide and its complexes with VO(IV, Cr(III, Mn(III, Fe(III, MoO2(VI, WO2(VI, Zr(IV and UO2(VI have been prepared. They were characterized by elemental analysis, IR and electronic spectra, magnetic susceptibility measurements and thermal analyses. The Schiff base ligand has also been characterised by 1H-NMR spectroscopy. The thermal behaviour of metal complexes shows that the hydrated complexes lose water molecules of hydration in the first and then is immediately followed by decomposition of ligand molecule in the subsequent steps. The IR spectra suggest that ligand acts as dibasic tetradentate nature and coordination takes place through azomethine nitrogen and phenolate oxygen. The crystalline nature of the VO(IV complex was conformed through the powder XRD analysis. The catalytic activity of the VO(IV and Mn(III complexes have been tested in the epoxidation reaction of styrene and conversion of styrene were 11.14-24.35% and 9.64-23.42%, respectively. The solid state electrical conductivity of ligand and its complexes were measured, which could obeyed the relation s = s0 exp (Ea/KT over the temperature range 313-413 K. DOI: http://dx.doi.org/10.4314/bcse.v29i3.6

  9. Size Switchable Supramolecular Nanoparticle Based on Azobenzene Derivative within Anionic Pillar[5]arene

    Science.gov (United States)

    Zhang, Cai-Cai; Li, Sheng-Hua; Zhang, Cui-Fang; Liu, Yu

    2016-11-01

    A photo/thermal-switchable supramolecular nanoparticles assembly has been constructed based on an inclusion complex between anionic pillar[5]arene 2C-WP5A and azobenzene derivative Azo-py-OMe (G). The novel anionic pillar[5]arene-based host-guest inclusion complexation was investigated by the 1H NMR titration, 2D ROESY and isothermal titration microcalorimetry (ITC) showing high association constant (Ka) of (2.60 ± 0.06) × 104 M-1 with 1:1 binding stoichiometry. Furthermore, the supramolecular nanoparticles assembly can be conveniently obtained from G and a small amount of 2C-WP5A in aqueous solution, which was so-called “host induced aggregating (HIA)”. The size and morphology of the supramolecular nanoparticles assembly were characterized by TEM and DLS. As a result of the photo/thermal-isomerization of G included in the cavity of 2C-WP5A, the size of these nanoparticles could reversibly change from ~800 nm to ~250 nm, which could switch the solution of this assembly from turbid to clear.

  10. Deriving Shape-Based Features for C. elegans Locomotion Using Dimensionality Reduction Methods.

    Science.gov (United States)

    Gyenes, Bertalan; Brown, André E X

    2016-01-01

    High-throughput analysis of animal behavior is increasingly common following the advances of recording technology, leading to large high-dimensional data sets. This dimensionality can sometimes be reduced while still retaining relevant information. In the case of the nematode worm Caenorhabditis elegans, more than 90% of the shape variance can be captured using just four principal components. However, it remains unclear if other methods can achieve a more compact representation or contribute further biological insight to worm locomotion. Here we take a data-driven approach to worm shape analysis using independent component analysis (ICA), non-negative matrix factorization (NMF), a cosine series, and jPCA (a dynamic variant of principal component analysis [PCA]) and confirm that the dimensionality of worm shape space is close to four. Projecting worm shapes onto the bases derived using each method gives interpretable features ranging from head movements to tail oscillation. We use these as a comparison method to find differences between the wild type N2 worms and various mutants. For example, we find that the neuropeptide mutant nlp-1(ok1469) has an exaggerated head movement suggesting a mode of action for the previously described increased turning rate. The different bases provide complementary views of worm behavior and we expect that closer examination of the time series of projected amplitudes will lead to new results in the future.

  11. Deriving shape-based features for C. elegans locomotion using dimensionality reduction methods

    Directory of Open Access Journals (Sweden)

    Bertalan Gyenes

    2016-08-01

    Full Text Available High-throughput analysis of animal behavior is increasingly common following advances of recording technology, leading to large high-dimensional data sets. This dimensionality can sometimes be reduced while still retaining relevant information. In the case of the nematode worm Caenorhabditis elegans, more than 90% of the shape variance can be captured using just four principal components. However, it remains unclear if other methods can achieve a more compact representation or contribute further biological insight to worm locomotion. Here we take a data-driven approach to worm shape analysis using independent component analysis (ICA, non-negative matrix factorization (NMF, a cosine series, and jPCA (a dynamic variant of principal component analysis and confirm that the dimensionality of worm shape space is close to four. Projecting worm shapes onto the bases derived using each method gives interpretable features ranging from head movements to tail oscillation. We use these as a comparison method to find differences between the wild type N2 worms and various mutants. For example, we find that the neuropeptide mutant nlp-1(ok1469 has an exaggerated head movement suggesting a mode of action for the previously described increased turning rate. The different bases provide complementary views of worm behavior and we expect that closer examination of the time series of projected amplitudes will lead to new results in the future.

  12. Recent developments and future prospects on bio-based polyesters derived from renewable resources: A review.

    Science.gov (United States)

    Zia, Khalid Mahmood; Noreen, Aqdas; Zuber, Mohammad; Tabasum, Shazia; Mujahid, Mohammad

    2016-01-01

    A significantly growing interest is to design a new strategy for development of bio-polyesters from renewable resources due to limited fossil fuel reserves, rise of petrochemicals price and emission of green house gasses. Therefore, this review aims to present an overview on synthesis of biocompatible, biodegradable and cost effective polyesters from biomass and their prospective in different fields including packaging, coating, tissue engineering, drug delivery system and many more. Isosorbide, 2,4:3,5-di-O-methylene-d-mannitol, bicyclic diacetalyzed galactaric acid, 2,5-furandicarboxylic acid, citric, 2,3-O-methylene l-threitol, dimethyl 2,3-O-methylene l-threarate, betulin, dihydrocarvone, decalactone, pimaric acid, ricinoleic acid and sebacic acid, are some important monomers derived from biomass which are used for bio-based polyester manufacturing, consequently, replacing the petrochemical based polyesters. The last part of this review highlights some recent advances in polyester blends and composites in order to improve their properties for exceptional biomedical applications i.e. skin tissue engineering, guided bone regeneration, bone healing process, wound healing and wound acceleration. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Analyzing dynamic fault trees derived from model-based system architectures

    International Nuclear Information System (INIS)

    Dehlinger, Josh; Dugan, Joanne Bechta

    2008-01-01

    Dependability-critical systems, such as digital instrumentation and control systems in nuclear power plants, necessitate engineering techniques and tools to provide assurances of their safety and reliability. Determining system reliability at the architectural design phase is important since it may guide design decisions and provide crucial information for trade-off analysis and estimating system cost. Despite this, reliability and system engineering remain separate disciplines and engineering processes by which the dependability analysis results may not represent the designed system. In this article we provide an overview and application of our approach to build architecture-based, dynamic system models for dependability-critical systems and then automatically generate Dynamic Fault Trees (DFT) for comprehensive, toolsupported reliability analysis. Specifically, we use the Architectural Analysis and Design Language (AADL) to model the structural, behavioral and failure aspects of the system in a composite architecture model. From the AADL model, we seek to derive the DFT(s) and use Galileo's automated reliability analyses to estimate system reliability. This approach alleviates the dependability engineering - systems engineering knowledge expertise gap, integrates the dependability and system engineering design and development processes and enables a more formal, automated and consistent DFT construction. We illustrate this work using an example based on a dynamic digital feed-water control system for a nuclear reactor

  14. The usefulness of sup(99m)Tc-DTPA renogram in the functional and diagnostic evaluations of chronic renal insufficiency in children

    International Nuclear Information System (INIS)

    Matsueda, Yoriko; Hiraiwa, Mikio; Meguro, Hidenori; Fujii, Ryochi

    1980-01-01

    As there are some difficulties in the performance of renal biopsy and intravenous pyelography is of little use in children with chronic renal insufficiency, we evaluated the usefulness of sup(99m)Tc-DTPA renogram in two children. The causes of the renal insufficiency presented were obstructive congenital anomalies and chronic pyelonephritis in one patient and polycystic kidneys in the other. As expected, intravenous pyelography poorly visualized in the upper urinary tracts of both the cases examined. sup(99m)Tc-DTPA renogram gave us distinct image for the diagnosis of the kidneys and urinary tracts, and the individual renal functions were clarified as well. It was apparently superior to the combined use of sup(99m)Tc-DMSA renoscintigram and 131 I-Hippuran renogram in both the imaging and functional evaluations. In such cases as are reported herein, sup(99m)Tc-DTPA renogram might be a useful alternative to several other diagnostic tests. (author)

  15. Influence of hydration status in normal subjects. Fractional analysis of parameters of Tc-99m DTPA and Tc-99m MAG3 renography

    International Nuclear Information System (INIS)

    Jung, Hyun Suk; Chung, Yong An; Kim, Eui Neyng; Kim, Sung Hoon; Lee, Sung Yong; Sohn, Hyung Sun; Park, Young Ha; Chung, Soo Kyo

    2005-01-01

    The purpose of this study was to evaluate the influence of hydration status upon renogram patterns and renal physiological parameters and clarify the differences between DTPA and MAG 3 studies in normal volunteers. The study populations were 22 kidneys of 11 volunteers with no history of hypertension or renal disease with normal serum creatinine levels. They were 6 men and 5 women aged from 24 to 48 yrs (mean age: 33.4 yrs). Renal scintigraphies with both 185 MBq (5 mCi) of Tc-99m DTPA and Tc-99m MAG 3 were performed after dehydration (urine specific gravity >1.025) and adequate hydration (urine specific gravity 3 with the whole kidney and cortical ROIs. Dehydration may bring about a false positive curve pattern on renograms which can be prevented or minimized by using the cortical ROI. There were insignificant differences between most parameters of Tc-99m DTPA and Tc-99m MAG 3 . (author)

  16. Removal of plutonium and americium from the rat using 3,4,3-LIHOPO and DTPA after simulated wound contamination: effect of delayed administration and mass of plutonium

    International Nuclear Information System (INIS)

    Gray, S.A.; Stradling, G.N.; Pearce, M.J.; Wilson, I.; Moody, J.C.; Burgada, R.; Durbin, P.W.; Raymond, K.N.

    1994-01-01

    The comparative efficacies of treatment with 3,4,3-LIHOPO and DTPA have been investigated in the rat after their subcutaneous intramuscular injection. Commencement of treatment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d. Under all conditions, 3,4,3-LIHOPO was considerably more effective than DTPA, although the efficacy of both ligands and their relative effectiveness decreased rapidly with their delay in administration. After early treatment of the intramuscular deposit of Pu and Am with 3,4,3-LIHOPO, the body content of Pu and Am was about 1% of those in untreated animals and about 30 times less than when using the same treatment regimen with DTPA. The value for Pu increased to 5% of controls when the amount deposited increased from 1.5 ng to 0.9 mg.kg -1 body mass. (author)

  17. Cost comparison of 111In-DTPA-octreotide scintigraphy and 68Ga-DOTATOC PET/CT for staging enteropancreatic neuroendocrine tumours

    International Nuclear Information System (INIS)

    Schreiter, Nils F.; Brenner, Winfried; Buchert, Ralph; Prasad, Vikas; Nogami, Munenobu; Huppertz, Alexander; Pape, Ulrich-Frank; Hamm, Bernd; Maurer, Martin H.

    2012-01-01

    Although somatostatin receptor positron emission tomography (PET)/CT is gaining increasing popularity and has shown its diagnostic superiority in several studies, 111 In-diethylenetriaminepentaacetic acid (DTPA)-octreotide is still the current standard for diagnosis of neuroendocrine tumours (NET). The aim of this study was to compare the costs for the two diagnostic tests and the respective consequential costs. From January 2009 to July 2009, 51 consecutive patients with enteropancreatic NET who underwent contrast-enhanced 68 Ga-DOTATOC PET/CT (n = 29) or 111 In-DTPA-octreotide (mean 3 whole-body scans plus 1.6 low-dose single photon emission computed tomography/CT; n = 22) were included. For cost analysis, direct costs (equipment) and variable costs (material, labour) per examination were calculated. Additionally required CT and/or MRI examinations within the staging process were assessed as consequential costs. An additional deterministic sensitivity analysis was performed. A 68 Ga-DOTATOC PET/CT examination yielded total costs (equipment, personnel and material costs) of 548 EUR. On the other hand, an 111 In-DTPA-octreotide examination resulted in 827 EUR total costs. Costs for equipment and material had a share of 460 EUR/720 EUR for 68 Ga-DOTATOC/ 111 In-DTPA-octreotide and labour costs of 89 EUR/106 EUR. With 68 Ga-DOTATOC additional MRI had to be performed in 7% of the patients resulting in a mean of 20 EUR for supplementary imaging per patient; 82% of patients with 111 In-DTPA-octreotide needed additional MRI and/or CT resulting in mean additional costs of 161 EUR per patient. 68 Ga-DOTATOC PET/CT was considerably cheaper than 111 In-DTPA-octreotide with respect to both material and personnel costs. Furthermore, by using 68 Ga-DOTATOC PET/CT considerably fewer additional examinations were needed reducing the consequential costs significantly. (orig.)

  18. DFT investigation of Ni(II) adsorption onto MA-DTPA/PVDF chelating membrane in the presence of coexistent cations and organic acids.

    Science.gov (United States)

    Song, Laizhou; Zhao, Xiaodan; Fu, Jie; Wang, Xiuli; Sheng, Yiping; Liu, Xiaowei

    2012-01-15

    Melamine-diethylenetriaminepentaacetic acid/polyvinylidene fluoride (MA-DTPA/PVDF) chelating membrane bearing polyaminecarboxylate groups was used to remove Ni(II) from nickel plating effluents. Adsorption experiments were conducted to study the adsorption of the membrane towards Ni(II) in Ni(II)-Ca(II), Ni(II)-NH(4)(+), Ni(II)-Fe(III) binary systems, and Ni(II)-lactic acid, Ni(II)-succinic acid and Ni(II)-citric acid complex systems. For the ternary nickel plating processes, the effects of 3d transition metals including Fe(II), Co(II), Cu(II) and Zn(II) on Ni(II) adsorption were evaluated. The influences of the aforementioned coexistent cations and organic acids were elucidated by the continuum solvation model (COSMO)-corrected density functional theory (DFT) method. Geometries and complexation energies were analyzed for metal-MA-DTPA and Ni(II)-organic acid complexes. DFT results accord with the experimental data, indicating that DFT is helpful to evaluate the complexation between the membrane and metal cations. The coexistent Ca(II) tends to form more stable complex with MA-DTPA ligand than NH(4)(+) and Fe(III), and can interfere with the formation of Ni(II)-MA-DTPA complex. The complexing sequence of 3d metals with MA-DTPA ligand is Zn(II)DTPA complex. Copyright © 2011 Elsevier B.V. All rights reserved.

  19. Non-invasive detection of biliary leaks using Gd-EOB-DTPA-enhanced MR cholangiography: comparison with T2-weighted MR cholangiography

    International Nuclear Information System (INIS)

    Kantarci, Mecit; Pirimoglu, Berhan; Bayraktutan, Ummugulsum; Ogul, Hayri; Kizrak, Yesim; Eren, Suat; Karabulut, Nevzat; Ozturk, Gurkan; Aydinli, Bulent; Yilmaz, Sinan

    2013-01-01

    To evaluate the added role of T1-weighted (T1w) gadolinium ethoxybenzyl diethylenetriamine penta-acetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance cholangiography (MRC) compared with T2-weighted MRC (T2w-MRC) in the detection of biliary leaks. Ninety-nine patients with suspected biliary complications underwent routine T2w-MRC and T1w contrast-enhanced (CE) MRC using Gd-EOB-DTPA to identify biliary leaks. Two observers reviewed the image sets separately and together. MRC findings were compared with those of surgery and percutaneous transhepatic cholangiopancreatography. The sensitivity, specificity and accuracy of the techniques in identifying biliary leaks were calculated. Accuracy of locating biliary leaks was superior with the combination of Gd-EOB-DTPA-enhanced MRC and T2w-MRC (P < 0.05).The mean sensitivities were 79 % vs 59 %, and the mean accuracy rates were 84 % vs 58 % for combined CE-MRC and T2w-MRC vs sole T2w-MRC. Nineteen out of 21 patients with biliary-cyst communication, 90.4 %, and 12/15 patients with post-traumatic biliary extravasations, 80 %, were detected by the combination of Gd-EOB-DTPA-enhanced MRC and T2w-MRC images, P < 0.05. Gd-EOB-DTPA-enhanced MRC yields information that complements T2w-MRC findings and improves the identification and localisation of the bile extravasations (84 % accuracy, 100 % specificity, P < 0.05). We recommend Gd-EOB-DTPA-enhanced MRC in addition to T2w-MRC to increase the preoperative accuracy of identifying and locating extravasations of bile. (orig.)

  20. Silver ion recognition using potentiometric sensor based on recently synthesized isoquinoline-1,3-dione derivatives

    Directory of Open Access Journals (Sweden)

    AJAR KAMAL

    2012-08-01

    Full Text Available The four derivatives of isoquinoline-1,3-dione based on β-lactum (I-IV, have been explored as neutral ionophores for preparing poly(vinylchloride based polymeric membrane electrodes (PME selective to silver(I ions. The addition of sodium tetraphenylborate (NaTPB and dioctylsebacate (DOS as a plasticizer was found to improve the performance of ion selective electrodes. The best performance was obtained with PME-1 based on ionophore I having composition: ionophore (9.2 mg, PVC (100.1 mg, DOS (201.1 mg and NaTPB (1.5 mg in 5 mL tetrahydrofuran. The electrode response was linear with Nernstian slope of 58.44 mV/decade in the concentration range of 1.0 x 10-1 M to 5.0 x 10-6 M and detection limit of 5.83 x 10-6 M. It performs satisfactorily over wide pH range of 1.0-5.5. The proposed sensor can be used over a period of more than three months without any significant drift in potential and shows good selectivity to silver(I ion over a number of cations especially with no interference of mercury(II ions. Sharp end point was obtained when the sensor was used as an indicator electrode for the potentiometric titration of silver(I ions with chloride ions and therefore this electrode (PME-1 could be used for quantitative determination of silver(I ion in synthetic water, silver foil and dental amalgam samples.

  1. A fungal phylogeny based on 42 complete genomes derived from supertree and combined gene analysis

    Directory of Open Access Journals (Sweden)

    Stajich Jason E

    2006-11-01

    Full Text Available Abstract Background To date, most fungal phylogenies have been derived from single gene comparisons, or from concatenated alignments of a small number of genes. The increase in fungal genome sequencing presents an opportunity to reconstruct evolutionary events using entire genomes. As a tool for future comparative, phylogenomic and phylogenetic studies, we used both supertrees and concatenated alignments to infer relationships between 42 species of fungi for which complete genome sequences are available. Results A dataset of 345,829 genes was extracted from 42 publicly available fungal genomes. Supertree methods were employed to derive phylogenies from 4,805 single gene families. We found that the average consensus supertree method may suffer from long-branch attraction artifacts, while matrix representation with parsimony (MRP appears to be immune from these. A genome phylogeny was also reconstructed from a concatenated alignment of 153 universally distributed orthologs. Our MRP supertree and concatenated phylogeny are highly congruent. Within the Ascomycota, the sub-phyla Pezizomycotina and Saccharomycotina were resolved. Both phylogenies infer that the Leotiomycetes are the closest sister group to the Sordariomycetes. There is some ambiguity regarding the placement of Stagonospora nodurum, the sole member of the class Dothideomycetes present in the dataset. Within the Saccharomycotina, a monophyletic clade containing organisms that translate CTG as serine instead of leucine is evident. There is also strong support for two groups within the CTG clade, one containing the fully sexual species Candida lusitaniae, Candida guilliermondii and Debaryomyces hansenii, and the second group containing Candida albicans, Candida dubliniensis, Candida tropicalis, Candida parapsilosis and Lodderomyces elongisporus. The second major clade within the Saccharomycotina contains species whose genomes have undergone a whole genome duplication (WGD, and their close

  2. {sup 99m}Tc-N, N'-bis(aminoethyl)propanediamine hexaacetic acid (BPHA): a glomerular filtration agent similar to {sup 99m}Tc-DTPA

    Energy Technology Data Exchange (ETDEWEB)

    Liu Guozheng E-mail: Guozheng.Liu@umassmed.edu; Zhang Chunli; Liu Fei; Wang Rongfu; Fu Zhanli; Li Guiqun; Miao Zengxing

    2002-05-01

    Investigations on the biodistribution of {sup 99m}Tc-BPHA in normal and probenecid treated mice and a comparison with {sup 99m}Tc-DTPA injected mice suggested that {sup 99m}Tc-BPHA is also a glomerular filtration agent. Whole body radioactivity measurements in mice and rabbits after administration of {sup 99m}Tc-BPHA showed negligible whole body radioactivity at 24 h. Excellent kidney images both in rabbits and a human volunteer were obtained. The significance of higher GFR estimates using {sup 99m}Tc-BPHA compared to {sup 99m}Tc-DTPA is discussed.

  3. The thoracic aortography by Gd-DTPA enhanced ultrafast cine MR imaging. Assessment of thoracic aortic dilatation in aging and in patients with hypertension and aortic valve disease

    International Nuclear Information System (INIS)

    Matsumura, Kentaro; Nakase, Emiko; Kawai, Ichiyoshi; Saito, Takayuki; Kikkawa, Nobutada; Haiyama, Toru

    1995-01-01

    To assess the morphology of thoracic aorta, we had a trial of Gd-DTPA enhanced ultrafast cine MR imaging on the thoracic aorta. This method was provided with high quality thoracic aortogram during 15-20 seconds. In patients without hypertension and aortic valve disease, dimensions of ascending aorta and aortic arch were significantly correlated with aging. In patients with hypertension, dimensions of ascending aorta and aortic arch were significantly dilated. In patients with aortic valve disease, thoracic aorta was diffusely enlarged, especially in ascending aorta. Gd-DTPA enhanced ultrafact cine MR imaging was useful to assess the thoracic aortic anatomy and diseases. (author)

  4. The synthesis of a D-glucosamine contrast agent, Gd-DTPA-DG, and its application in cancer molecular imaging with MRI

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Wei [Department of Nuclear Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000 (China); Chen Yue, E-mail: chenyue5523@126.com [Department of Nuclear Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000 (China); Guo Dajing [Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010 (China); Huang Zhanwen; Cai Liang [Department of Nuclear Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000 (China); He Ling [West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041 (China)

    2011-09-15

    Objective: The purpose of this study is to describe the synthesis of Gadolinium-diethylenetriamine pentaacetic acid-deoxyglucosamine (Gd-DTPA-DG) which is a D-glucosamine metabolic MR imaging contrast agent. We will also discuss its use in a pilot MRI study using a xenograft mouse model of human adenocarcinoma. Methods: This novel contrast agent was specifically studied because of its ability to 'target' metabolically active tumor tissues. In this study Gd-DTPA-DG is used to investigate how tumor tissues would react to a dose of 0.2 mmol Gd/kg over a 120 min exposure in a xenograft mouse model. These experiments used athymic mice implanted with human pulmonary adenocarcinoma (A549) as demonstrated by dynamic MRI. Alternately, another contrast agent that is not specific for targeting, Gd-DTPA, was used as the control at a similar dose of gadolinium. Efficacy of the targeted contrast agent was assessed by measuring relaxation rate in vitro and signal intensity (SI) in vivo. Statistical differences were calculated using one-way analysis of variance. Results: The synthesized Gd-DTPA-DG was shown to improve the contrast of tumor tissue in this model. Gd-DTPA-DG was also shown to have a similar pharmacokinetic rate but generated a higher relaxation rate in tumor tissues relative to the control contrast Gd-DTPA. In comparison to the pre-contrast imaging, the SI of tumor tissue in the experimental group was shown to be significantly increased at 15 min after injection of Gd-DTPA-DG (p < 0.001). The enhanced signal intensity spread from the edge of the tumor to the center and seemed to strengthen the idea that MRI performance would be useful in different tumor tissues. Conclusion: This preliminary study shows that this new chelated contrast agent, Gd-DTPA-DG, can be specifically targeted to accumulation in tumor tissue as compared to normal tissues. This targeted paramagnetic contrast agent has potential for specific cancer molecular imaging with MRI.

  5. MR angiography of collateral arteries in a hind limb ischemia model: comparison between blood pool agent Gadomer and small contrast agent Gd-DTPA.

    Directory of Open Access Journals (Sweden)

    Karolien Jaspers

    Full Text Available The objective of this study was to compare the blood pool agent Gadomer with a small contrast agent for the visualization of ultra-small, collateral arteries (diameter0.10. Inter-observer variation was 24% and 18% for Gadomer and Gd-DTPA, respectively. In conclusion, blood pool agent Gadomer improved vessel conspicuity compared to Gd-DTPA. Steady-state MRA can be considered as an excellent non-invasive alternative to intra-arterial XRA for the visualization of ultra-small collateral arteries.

  6. Oral contrast media for MR imaging of the abdomen. Pt. 4. Clinical trail on safety and efficacy of gadopentetate-dimeglumine. Orale Kontrastmittel fuer die magnetische Resonanztomographie des Abdomens. T. 4. Klinische Pruefung der Vertraeglichkeit von Gadolinium-DTPA

    Energy Technology Data Exchange (ETDEWEB)

    Kaminsky, S.; Gogoll, M.; Kornmesser, W.; Felix, R. (Klinikum Rudolf Virchow, Berlin (Germany). Strahlenklinik und Poliklinik); Laniado, M. (Tuebingen Univ. (Germany). Radiologische Klinik); Clauss, W. (Schering AG, Berlin (Germany))

    1992-01-01

    Safety and efficacy of gadopentetate-dimeglumine (Gd-DTPA) as a MR bowel contrast agent were determined in 133 patients with CT-proved abdominal and retroperitoneal mass lesions using a buffered formulation (1 mmol/l Gd-DTPA, 15 g/l mannitol, 25 mmol/l sodium-citrate, 6- 17 ml/kg). Short-lived gastrointestinal side effects were noted in 32% of patients. Gd-DTPA provided uniform, hyperintense bowel labelling and contrast enhancement in the region of interest in 81% of patients. Among 78 patients with pre- and postcontrast images lesion delineation was improved in 62%. In 55 studies with postcontrast images only, Gd-DTPA proved useful in 65%. In 105 of 109 cases IV injection of scopolamine or glucagon eliminated image artifacts arising from peristaltis of opacified bowel. The authors conclude that Gd-DTPA is a safe and effective MR bowel contrast agent. (orig.).

  7. New borehole-derived results on temperatures at the base of the Fennoscandian ice sheet

    Science.gov (United States)

    Rath, Volker; Vogt, Christian; Mottaghy, Darius; Kukkonen, Ilmo; Tarasov, Lev

    2014-05-01

    During the last few years, a data base of deep boreholes (>1000 m )in the area of the Fennoscandian ice sheet has been collected, including boreholes from Russia, Poland, Finland, Sweden and Norway. All of these are supposed to have recorded local basal ice conditions during the last glacial cycle. However, at each of these sites we are confronted with particular problems of interpretation. Here, we will concentrate on two very deep boreholes, namely the Outokumpu ICDP borehole (OKU, ≡2500 m) and a set of boreholes of intermediate depth (up to 1300 m) in the immediate meighborhood of the Kola superdeep borehole SG3. In the first case, OKU, we have developed a strategy combining the use of a traditional variational inversion of thye Tikhonov type, with a MCMC approach for the exploration of the associated uncertainty. A wide distribution around the result of the variational approach was chosen, with a time dependent temporal correlation length reflecting the loss of resolution back in time. The results fit very well with region independent results from different proxies, multi-proxy reconstructions, and instrumental data. They also are consistent with surface temperatures derived from recent calibrated ice sheet models. The SAT-GST offset independently derived from shallow borehole observations in the area was a crucial step to obtain theses results. The second case, SG3, has been studied a long time, and no final result was obtained regarding the question whether the observed heat flow density profile is caused by paleoclimate, fluid flow, or both. Earlier studies, as well as forward modelling using the results of the aforementioned ice sheet model indicate that paleoclimate alone can not explain the observations. We tested the model derived from the set of shallow boreholes against the temperature log from the main superdeep SG3, which, in contrast to these, transects the main high-permeability zone. The comparison led to a favorable results, and is also

  8. Evaluation of methods to derive green-up dates based on daily NDVI satellite observations

    Science.gov (United States)

    Doktor, Daniel

    2010-05-01

    Bridging the gap between satellite derived green-up dates and in situ phenological observations has been the purpose of many studies over the last decades. Despite substantial advancements in satellite technology and data quality checks there is as yet no universally accepted method for extracting phenological metrics based on satellite derived vegetation indices. Dependent on the respective method derived green-up dates can vary up to serveral weeks using identical data sets. Consequently, it is difficult to compare various studies and to accurately determine an increased vegetation length due to changing temperature patterns as observed by ground phenological networks. Here, I compared how the characteristic NDVI increase over temperate deciduous forests in Germany in spring relates to respective budburst events observed on the ground. MODIS Terra daily surface reflectances with a 250 m resolution (2000-2008) were gathered to compute daily NDVI values. As ground truth, observations of the extensive phenological network of the German Weather Service were used. About 1500 observations per year and species (Beech, Oak and Birch) were available evenly distributed all over Germany. Two filtering methods were tested to reduce the noisy raw data. The first method only keeps NDVI values which are classified as ‚ideal global quality' and applies on those a temporal moving window where values are removed which differ more than 20% of the mean. The second method uses an adaptation of the BISE (Best Index Slope Extraction) algorithm. Subsequently, three functions were fitted to the selected observations: a simple linear interpolation, a sigmoidal function and a double logistic sigmoidal function allowing to approximate two temporally separated green-up signals. The green-up date was then determined at halfway between minimum and maximum (linear interpolation) or at the inflexion point of the sigmoidal curve. A number of global threshold values (NDVI 0.4,0.5,0.6) and

  9. Synthesis and reactivity of some Mannich bases. VIII. Studies on several Mannich bases derived from ortho-hidroxyacetophenones and their conversion into oximino derivatives

    Directory of Open Access Journals (Sweden)

    BOGDAN COMANITA

    2001-01-01

    Full Text Available The synthesis of several Mannich bases resulting from the reaction of 2-hydroxy-4-methylacetophenone with paraformaldehyde and secondary amines is reported. Another series of products was obtained from N,N-dimethyl substituted Mannich bases by replacing the amino group with pyrrolidine. Most of the Mannich bases were transformed into oximes by treatment with hydroxylamine hydrochloride in 10 % NaOH.

  10. Enzyme assay for identification of pectin and pectin derivatives, based on recombinant pectate lyase.

    Science.gov (United States)

    Hansen, K M; Truesen, A B; Søderberg, J R

    2001-01-01

    A simple method was developed for fast identification of pectin, based on a recombinant endopectate lyase cloned from Aspergillus niger. When pectin was demethylated and treated with pectate lyase, beta-elimination occurred, resulting in a double bond between C-4 and C-5 in the galacturonic acid residue of the released nonreducing end. The formation of double bonds produced an increase in light absorption, which was detected at 235 nm. The assay was tested on pectin of different origins (apple, orange, sugar beet, sunflower, celery, lemon), pectin derivatives (amidated pectin), and speciality types such as low molecular weight and low %DE (degree of esterification, percentage of galacturonic acid groups esterified with methanol) pectin. The highest response was given by pectate (pectin with %DEgums (carboxymethylcellulose, carrageenan, locust bean gum, tragacanth, gellan, tamarind, xanthan, amylogum, sodium alginate, or agar) gave any response. Members of IPPA (International Pectin Producers Association) have evaluated the validity of the assay in a ring test. All members of the Association were able to identify pectin from other gums in a blind test. The method can replace more laborious and ambiguous identification tests which exist today.

  11. Emerging RNA-based drugs: siRNAs, microRNAs and derivates.

    Science.gov (United States)

    Pereira, Tiago Campos; Lopes-Cendes, Iscia

    2012-09-01

    An emerging new category of therapeutic agents based on ribonucleic acid has emerged and shown very promising in vitro, animal and pre-clinical results, known as small interfering RNAs (siRNAs), microRNAs mimics (miRNA mimics) and their derivates. siRNAs are small RNA molecules that promote potent and specific silencing of mutant, exogenous or aberrant genes through a mechanism known as RNA interference. These agents have called special attention to medicine since they have been used to experimentally treat a series of neurological conditions with distinct etiologies such as prion, viral, bacterial, fungal, genetic disorders and others. siRNAs have also been tested in other scenarios such as: control of anxiety, alcohol consumption, drug-receptor blockage and inhibition of pain signaling. Although in a much earlier stage, miRNAs mimics, anti-miRs and small activating RNAs (saRNAs) also promise novel therapeutic approaches to control gene expression. In this review we intend to introduce clinicians and medical researchers to the most recent advances in the world of siRNA- and miRNA-mediated gene control, its history, applications in cells, animals and humans, delivery methods (an yet unsolved hurdle), current status and possible applications in future clinical practice.

  12. A Gaussian process and derivative spectral-based algorithm for red blood cell segmentation

    Science.gov (United States)

    Xue, Yingying; Wang, Jianbiao; Zhou, Mei; Hou, Xiyue; Li, Qingli; Liu, Hongying; Wang, Yiting

    2017-07-01

    As an imaging technology used in remote sensing, hyperspectral imaging can provide more information than traditional optical imaging of blood cells. In this paper, an AOTF based microscopic hyperspectral imaging system is used to capture hyperspectral images of blood cells. In order to achieve the segmentation of red blood cells, Gaussian process using squared exponential kernel function is applied first after the data preprocessing to make the preliminary segmentation. The derivative spectrum with spectral angle mapping algorithm is then applied to the original image to segment the boundary of cells, and using the boundary to cut out cells obtained from the Gaussian process to separated adjacent cells. Then the morphological processing method including closing, erosion and dilation is applied so as to keep adjacent cells apart, and by applying median filtering to remove noise points and filling holes inside the cell, the final segmentation result can be obtained. The experimental results show that this method appears better segmentation effect on human red blood cells.

  13. Chiral copper(II) complex based on natural product rosin derivative as promising antitumour agent.

    Science.gov (United States)

    Fei, Bao-Li; Huang, Zhi-Xiang; Xu, Wu-Shuang; Li, Dong-Dong; Lu, Yang; Gao, Wei-Lin; Zhao, Yue; Zhang, Yu; Liu, Qing-Bo

    2016-07-01

    To evaluate the biological preference of chiral drug candidates for molecular target DNA, the synthesis and characterization of a chiral copper(II) complex (2) of a chiral ligand N,N'-(pyridin-2-ylmethylene) dehydroabietylamine (1) was carried out. The interactions of 1 and 2 with salmon sperm DNA were investigated by viscosity measurements, UV, fluorescence and circular dichroism (CD) spectroscopic techniques. Absorption spectral, emission spectral and viscosity analysis reveal that 1 and 2 interacted with DNA through intercalation and 2 exhibited a higher DNA binding ability. In the absence/presence of ascorbic acid, 1 and 2 cleaved supercoiled pBR322 DNA by single-strand and 2 displayed stronger DNA cleavage ability. In addition, in vitro cytotoxicity of 1 and 2 against HeLa, SiHa, HepG-2 and A431 cancer cell lines study show that they exhibited effective cytotoxicity against the tested cell lines, notably, 2 showed a superior cytotoxicity than the widely used drug cisplatin under identical conditions, indicating it has the potential to act as effective anticancer drug. Flow cytometry analysis indicates 2 produced death of HeLa cancer cells through an apoptotic pathway. Cell cycle analysis demonstrates that 2 mainly arrested HeLa cells at the S phase. The study represents the first step towards understanding the mode of the promising chiral rosin-derivative based copper complexes as chemotherapeutics. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. An Atomistic Carbide-Derived Carbon Model Generated Using ReaxFF-Based Quenched Molecular Dynamics

    Directory of Open Access Journals (Sweden)

    Matthew W. Thompson

    2017-10-01

    Full Text Available We report a novel atomistic model of carbide-derived carbons (CDCs, which are nanoporous carbons with high specific surface areas, synthesis-dependent degrees of graphitization, and well-ordered, tunable porosities. These properties make CDCs viable substrates in several energy-relevant applications, such as gas storage media, electrochemical capacitors, and catalytic supports. These materials are heterogenous, non-ideal structures and include several important parameters that govern their performance. Therefore, a realistic model of the CDC structure is needed in order to study these systems and their nanoscale and macroscale properties with molecular simulation. We report the use of the ReaxFF reactive force field in a quenched molecular dynamics routine to generate atomistic CDC models. The pair distribution function, pore size distribution, and adsorptive properties of this model are reported and corroborated with experimental data. Simulations demonstrate that compressing the system after quenching changes the pore size distribution to better match the experimental target. Ring size distributions of this model demonstrate the prevalence of non-hexagonal carbon rings in CDCs. These effects may contrast the properties of CDCs against those of activated carbons with similar pore size distributions and explain higher energy densities of CDC-based supercapacitors.

  15. Green synthesis of novel quinoline based imidazole derivatives and evaluation of their antimicrobial activity

    Directory of Open Access Journals (Sweden)

    N.C. Desai

    2014-12-01

    Full Text Available We have described the conventional and microwave method for the synthesis of N-(4-((2-chloroquinolin-3-ylmethylene-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl(arylamides 3a–l. It is observed that the solvent-free microwave thermolysis is a convenient, rapid, high-yielding, and environmental friendly protocol for the synthesis of quinoline based imidazole derivatives when compared with conventional reaction in a solution phase. Antimicrobial activity of the newly synthesized compounds is screened in vitro on the following microbial cultures: Escherichia coli (MTCC 443, Pseudomonas aeruginosa (MTCC 1688, Staphylococcus aureus (MTCC 96, Streptococcus pyogenes (MTCC 442, Candida albicans (MTCC 227, Aspergillus niger (MTCC 282, Aspergillus clavatus (MTCC 1323. All the synthesized bio-active molecules are tested for their in vitro antimicrobial activity by bioassay namely serial broth dilution. Among these compounds 3c, 3d, 3f, 3h and 3j show significant potency against different microbial strains. All the compounds have been characterized by IR, 1H NMR, 13C NMR and mass spectral data. On the basis of statistical analysis, it is observed that these compounds give significant co-relation.

  16. Metallic Langmuir and Langmuir-Blodgett films based on TTF derivatives and fatty acid

    International Nuclear Information System (INIS)

    Ohnuki, H.; Ishizaki, Y.; Suzuki, M.; Desbat, B.; Delhaes, P.; Giffard, M.; Imakubo, T.; Mabon, G.; Izumi, M.

    2002-01-01

    Recent progress in the metallic conducting Langmuir-Blodgett (LB) films built from TTF derivative and fatty acids is reported. A simple LB method of transferring the mixed Langmuir (L) film of BEDO-TTF (BO) and stearic acid (SA) onto substrates provided metallic conducting LB films. A homogeneous L film formation on the water surface observed by Brewster angle microscope (BAM) is an essential factor for the well-ordered LB films. In the L film, the carboxylate group of fatty acid forms anion layer bringing about a spontaneous formation of mixed valence state (MVS) of BO layer. Similar spontaneous formation was also found in the molecular combination of nonoxygen-substituted donor of EDT-TTF and octadecanesulfonic acid (OS). This type of reaction would be useful for obtaining conducting LB films. For the LB films of BEDO-TTF and stearic acid, we found a negative transverse magnetoresistance at low temperature that was interpreted in the weak localization of a two-dimensional (2D) electronic system based on the well-defined conducting layer

  17. Derivation of an inhalation TTC for the workplace based on DNEL values reported under REACH.

    Science.gov (United States)

    Hoersch, Johanna; Hoffmann-Doerr, Simone; Keller, Detlef

    2018-03-27

    The Threshold of Toxicological Concern (TTC) concept defines a generic tolerable exposure for chemicals of unknown toxicity below which the risk of adverse health effects is considered very small. The original concept was refined and extended over the years, based either on differentiated structural classes or on additional information on certain toxicological endpoints. Initially, the focus of the TTC application was only on systemic toxic effects after repeated oral intake and consisted of one value. However, under well-defined boundary conditions, a long-term systemic inhalation TTC could also serve as a cut-off criterion for occupational exposure in those cases where workers are exposed to very low levels of chemicals by inhalation contact and could therefore reduce the need to perform animal tests. Within the scope of the European REACH legislation, several thousand systemic long-term inhalation Derived No Effect Levels (DNELs) for workers have been published. By statistical evaluation of the DNEL distribution of 1876 chemicals and the resulting 99th percentiles, we propose an inhalation workplace TTC for systemic effects in the region of 50 μg/m 3 (7 μg/kg body weight/day). Specific exclusion criteria apply for the discussed concept. Copyright © 2018 Elsevier B.V. All rights reserved.

  18. QUALITATIVE RISK COVERAGE IN AGRICULTURE THROUGH DERIVATIVE FINANCIAL INSTRUMENTS BASED ON SELYANINOV INDICES

    Directory of Open Access Journals (Sweden)

    Cristian KEVORCHIAN

    2013-09-01

    Full Text Available The financial product designed by the authors belongs to the class of derivative financial instruments, having “weather conditions” as basic variable; the settlement is oriented to options on OTC markets, which are able to adapt to the farmers’ risk exposure level. Unfortunately, they cause certain problems at position liquidation, and, moreover, due to lack of stock prices, they require proper evaluation models. The transformation of the weather risk into financial risk and its trading on financial markets relies on the willingness for risk taking of those groups of farmers which are using this particular financial instrument. One needs to emphasize that the proposed product is covering the risk for the production segment only of a specific crop that cannot be covered by the regular agricultural insurance, and it is based upon the Selyaninov index. The calculation formulae for a put type option will be presented: pay-off, strike, tick,and the level of the insurance premium for cereals. The reference weather stations will be: Tulcea, Brăila, Buzău, Galaţi, Focşani and Medgidia.

  19. Synthesis and Evaluation of New Benzodioxole- Based Thiosemicarbazone Derivatives as Potential Antitumor Agents

    Directory of Open Access Journals (Sweden)

    Mehlika Dilek Altıntop

    2016-11-01

    Full Text Available New benzodioxole-based thiosemicarbazone derivatives were synthesized and evaluated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cells. In order to examine the correlation between anticancer activity and cholinesterases, the compounds were evaluated for their inhibitory effects on AChE and BuChE. The most effective anticancer agents were investigated for their effects on DNA synthesis, apoptosis and mitochondrial membrane potential. 4-(1,3-Benzodioxol-5-yl-1-([1,1′-biphenyl]-4-ylmethylenethiosemicarbazide (5 was identified as the most promising anticancer agent against C6 and A549 cell lines due to its inhibitory effects on C6 and A549 cells and low toxicity to NIH/3T3 cells. Compound 5 increased early and late apoptosis in A549 and C6 cells. Compound 5 also caused disturbance on mitochondrial membrane potential and showed DNA synthesis inhibitory activity in A549 and C6 cells. Compound 5 was investigated for SIRT1 inhibitory activity to provide mechanistic insight and for that purpose docking studies were also performed for this compound on SIRT1. On the other hand, compound 5 did not show any inhibitory activity against AChE and BuChE. This outcome pointed out that there is no relationship between anticancer activity of compound 5 and cholinesterases.

  20. Synthesis and biological evaluation of triazole based uracil derivatives as novel DPP-4 inhibitors.

    Science.gov (United States)

    Li, Qing; Han, Li; Zhang, Bin; Zhou, Jinpei; Zhang, Huibin

    2016-10-12

    A series of triazole based uracil derivatives were designed and synthesized as novel DPP-4 inhibitors. Compound A01 was identified as a lead compound for SAR studies focused on the structural modification at the S 2' subsite of DPP-4. The novel analogues A02-A25 were obtained by modifying the substituents at the phenyl group, and B01-B09, by introducing the carbonyl group. On screening in DPP-4, compounds B03, B04 and B08 showed a significant improvement in DPP-4 inhibitory activities compared to compound A01 and showed comparable activities to the marketed DPP-4 inhibitor, alogliptin. Docking studies revealed new favorable binding modes of designed compounds in the S 2' subsite and proved that structural modifications in the S 2' subsite were an effective option to increase the inhibition of DPP-4. In vitro DPP-8 and DPP-9 tests indicated that all compounds showed excellent selectivity against DPP-8 and DPP-9. Further in vivo evaluation showed that compound B04 could significantly improve oral glucose tolerance in ICR mice and dose-dependently reduced glucose levels in type 2 diabetic C57BL/6 mice. These data suggest that compound B04 could be a promising DPP-4 inhibitor for future treatment of T2DM.

  1. Synthesis, Spectroscopic Characterization and Biological Activities of Transition Metal Complexes Derived from a Tridentate Schiff Base

    Directory of Open Access Journals (Sweden)

    J. Senthil Kumaran

    2013-01-01

    Full Text Available A new series of Cu (II, Ni (II, Co (II and Zn (II complexes have been synthesized from the Schiff base derived from 4-hydroxy-3-methoxybenzylidine-4-aminoantipyrine and 2-aminophenol. The structural features have been determined from their elemental analysis, magnetic susceptibility, molar conductance, Mass, IR, UV-Vis, 1H-NMR, 13C-NMR and ESR spectral studies. The redox behavior of the copper complex has been studied by cyclic voltammetry. The data confirm that the complexes have composition of ML2 type. The electronic absorption spectral data of the complexes propose an octahedral geometry around the central metal ion. All the metal complexes with DNA structure were guided by the presence of inter-molecular C–H⋯O and C–H⋯N hydrogen bonds. The biological activity of the synthesized compounds were tested against the bacterial species such as Bacillus subtilis, Staphylococcus aureus, Proteus vulgaris and fungal species such as Candida albicans by the well-diffusion method.

  2. Strategies to Automatically Derive a Process Model from a Configurable Process Model Based on Event Data

    Directory of Open Access Journals (Sweden)

    Mauricio Arriagada-Benítez

    2017-10-01

    Full Text Available Configurable process models are frequently used to represent business workflows and other discrete event systems among different branches of large organizations: they unify commonalities shared by all branches and describe their differences, at the same time. The configuration of such models is usually done manually, which is challenging. On the one hand, when the number of configurable nodes in the configurable process model grows, the size of the search space increases exponentially. On the other hand, the person performing the configuration may lack the holistic perspective to make the right choice for all configurable nodes at the same time, since choices influence each other. Nowadays, information systems that support the execution of business processes create event data reflecting how processes are performed. In this article, we propose three strategies (based on exhaustive search, genetic algorithms and a greedy heuristic that use event data to automatically derive a process model from a configurable process model that better represents the characteristics of the process in a specific branch. These strategies have been implemented in our proposed framework and tested in both business-like event logs as recorded in a higher educational enterprise resource planning system and a real case scenario involving a set of Dutch municipalities.

  3. Tin(IV Complexes of Schiff Base Derived from Amino Acid: Synthesis and Characteristic Spectral Studies

    Directory of Open Access Journals (Sweden)

    Robina Aman

    2013-01-01

    Full Text Available A new series of tin(IV complexes of general formula [Sn(L-1(Opri2] (1, [Sn(HL-12(Opri2] (2, [Sn(L-2(Opri2] (3, [Sn(HL-22(Opri2] (4, (L is dianion of Schiff bases derived from the condensation of 2-hydroxy-1-naphthaldehyde with glycine (L-1 and Lβ-alanine (L-2 was synthesized by reaction of tin(IV tetraisopropoxide with the ligands, in appropriate stoichiometric ratios (1 : 1 and 1 : 2. This would result in the replacement of the isopropoxide group from the tin(IV tetraisopropoxide and hydrogen(s from ligand with the azeotropical removal of isopropanol. An attempt has been made to prove the structure of the resulting complexes on the basis of elemental analysis, IR, 1H nuclear magnetic resonance. The binding site of the ligand was identified by IR spectroscopic measurement. In these complexes, the tin(IV centre is bonded to oxygen atom of the hydroxyl or carboxylate group. The spectra data suggest that the carboxylate group is coordinated to tin(IV centre in monodentate manner.

  4. Statistical aspects of essential derivation, with illustrations based on lettuce and barley

    NARCIS (Netherlands)

    Eeuwijk, van F.A.; Law, J.R.

    2004-01-01

    The concept of essential derivation was introduced by UPOV in 1991 to refine the scope of breeders' rights. The intention of the essential derivation concept was to confer breeders protection against fraudulent practices in which `new¿ varieties are produced from current, protected ones without a

  5. Fe-based Fischer Tropsch Synthesis of biomass-derived syngas: Effect of synthesis method

    Science.gov (United States)

    Khiet Mai; Thomas Elder; Les Groom; James J. Spivey

    2015-01-01

    Two 100Fe/4Cu/4K/6Zn catalysts were prepared using two different methods: coprecipitation or impregnation methods. The effect of the preparation methods on the catalyst structure, catalytic properties, and the conversion of biomass-derived syngas via Fischer–Tropsch synthesis was investigated. Syngas was derived from gasifying Southern pine woodchips and had the...

  6. Non-volatile memory devices based on polystyrene derivatives with electron-donating oligofluorene pendent moieties.

    Science.gov (United States)

    Liu, Cheng-Liang; Hsu, Jung-Ching; Chen, Wen-Chang; Sugiyama, Kenji; Hirao, Akira

    2009-09-01

    We report bistable non-volatile memory devices based on polystyrene derivatives containing pendent electron-donating mono-, di-, and tri(9,9-dihexylfluorene), which are denoted as poly(St-Fl), poly(St-Fl(2)), and poly(St-Fl(3)), respectively. The effects of the oligofluorene chain lengths and polymer surface structures on the memory characteristics were explored. Poly(St-Fl)-, poly(St-Fl(2))-, and poly(St-Fl(3))-based devices exhibited a flash memory characteristic with different turn-on threshold voltages of 2.8, 2.0, and 1.8 V, respectively, which was on the reverse trend with the highest occupied molecular orbital levels of -5.86, -5.80, and -5.77 eV. Moreover, the memory device showed a high ON/OFF current ratio of 2.5 x 10(4) and a long retention time of 10(4) s. The possible mechanism of the switching behavior was explained by the space-charge-limited-current theory and filamentary conduction. The larger aggregation domain size of the polymer thin film processed from the mixed solvent of chlorobenzene/N,N-dimethylformamide probably promoted the diffusion of the Al atoms into the polymer film and formed the conduction channel. Thus, it significantly reduced the turn-on threshold voltage on the studied polymer memory devices. The present study suggested that the polymer memory characteristics could be efficiently tuned through the pendent conjugated chain length and surface structures.

  7. Geocenter variations derived from a combined processing of LEO- and ground-based GPS observations

    Science.gov (United States)

    Männel, Benjamin; Rothacher, Markus

    2017-08-01

    GNSS observations provided by the global tracking network of the International GNSS Service (IGS, Dow et al. in J Geod 83(3):191-198, 2009) play an important role in the realization of a unique terrestrial reference frame that is accurate enough to allow a detailed monitoring of the Earth's system. Combining these ground-based data with GPS observations tracked by high-quality dual-frequency receivers on-board low earth orbiters (LEOs) is a promising way to further improve the realization of the terrestrial reference frame and the estimation of geocenter coordinates, GPS satellite orbits and Earth rotation parameters. To assess the scope of the improvement on the geocenter coordinates, we processed a network of 53 globally distributed and stable IGS stations together with four LEOs (GRACE-A, GRACE-B, OSTM/Jason-2 and GOCE) over a time interval of 3 years (2010-2012). To ensure fully consistent solutions, the zero-difference phase observations of the ground stations and LEOs were processed in a common least-squares adjustment, estimating all the relevant parameters such as GPS and LEO orbits, station coordinates, Earth rotation parameters and geocenter motion. We present the significant impact of the individual LEO and a combination of all four LEOs on the geocenter coordinates. The formal errors are reduced by around 20% due to the inclusion of one LEO into the ground-only solution, while in a solution with four LEOs LEO-specific characteristics are significantly reduced. We compare the derived geocenter coordinates w.r.t. LAGEOS results and external solutions based on GPS and SLR data. We found good agreement in the amplitudes of all components; however, the phases in x- and z-direction do not agree well.

  8. Donor-Acceptor Interface Stabilizer Based on Fullerene Derivatives toward Efficient and Thermal Stable Organic Photovoltaics.

    Science.gov (United States)

    Li, Junli; Zhu, Xiaoguang; Yuan, Tao; Shen, Jiulin; Liu, Jikang; Zhang, Jian; Tu, Guoli

    2017-02-22

    An interface stabilizer based on alkylation-functionalized fullerene derivatives, [6, 6]-Phenyl-C61-butyric acid (3,5-bis(octyloxy)phenyl)methyl ester (PCB-C8oc), was successfully synthesized and applied for the active layer of Organic Photovoltaics (OPVs). The PCB-C8oc can replace part of the phenyl-C61-buty-ric acid methyl ester (PCBM) and be distributed on the interface of poly(3-hexylthiophene) (P3HT) and PCBM to form P3HT/PCBM/PCB-C8oc ternary blends, leading to thermally stable and efficient organic photovoltaics. The octyl groups of PCB-C8oc exhibit intermolecular interaction with the hexyl groups of P3HT, and the fullerene unit of PCB-C8oc are in tight contact with PCBM. The dual functions of PCB-C8oc will inhibit the phase separation between electron donor and acceptor, thereby improving the stability of devices under long-time thermal annealing at high temperature. When doped with 10 wt % PCB-C8oc, the power conversion efficiency (PCE) of the P3HT system decreased from 3.54% to 2.88% after 48 h of thermal treatment at 150 °C, whereas the PCE of the reference device without PCB-C8oc dramatically dropped from 3.53% to 0.73%. When doping 10 or 20 wt % PCB-C8oc, the unannealed P3HT/PCBM/PCB-C8oc device achieved a higher PCE than the P3HT/PCBM device without any annealing following the same fabricating condition. For the PTB7/PCBM-based devices, after adding only 5 wt % PCB-C8oc, the OPVs also exhibited thermally stable morphology and better device performances. All these results demonstrate that the utilization of alkyl interchain interactions is an effective and practical strategy to control morphological evolution.

  9. Synthesis of samarium complexes with the derivative binder of Schiff Quinolinic base. Characterization and photophysical study

    International Nuclear Information System (INIS)

    Lucas H, J.

    2016-01-01

    In this work we determined the metal: binder stoichiometry of the species formed during the UV/Vis spectrophotometric titration of the derivative binder of Schiff quinolinic base, L1 with the samarium nitrate pentahydrate in methanol. Statistical analysis of the data allowed proposing the metal: binder stoichiometry for the synthesis of the complexes which was one mole of samarium salt by 2.5 moles of binder and thus favor the formation of complexes with 1M: 1L and 1M: 2L stoichiometries. They were synthesized in aqueous-organic medium (water-ethanol), isolated and purified two complexes with stoichiometry 1 Sm: 1 L1, complex 1 and 1 Sm: 2 L1, complex 2. The overall yield of the reaction was 76%. The characterization of the formed complexes was performed by visible ultraviolet spectrometry (UV/Vis), nuclear magnetic resonance, X-ray photoelectron spectroscopy (XP S), thermal gravimetric analysis with differential scanning calorimetry (TGA/DSC), and radial distribution function. These complexes were studied by fluorescence and emission phosphorescence at variable temperature. Spectroscopic techniques used in both solution and solid demonstrated the formation and stability of these complexes. In addition XP S indicated that in both complexes the samarium retains its oxidation state 3+. Luminescence studies indicated that there is intra-binding charge transfer which decreases the transfer of light energy from the binder to the samarium. Based on the experimental results, L1 binder molecules and complexes 1 and 2 were modeled that demonstrated the proposed Nc for each complex, as well as allowed to visualize the structural arrangement of the molecules, complexes and binder. (Author)

  10. Assessing Viability and Sustainability: a Systems-based Approach for Deriving Comprehensive Indicator Sets

    Directory of Open Access Journals (Sweden)

    Hartmut Bossel

    2002-01-01

    Full Text Available Performance assessment in holistic approaches such as integrated natural resource management has to deal with a complex set of interacting and self-organizing natural and human systems and agents, all pursuing their own "interests" while also contributing to the development of the total system. Performance indicators must therefore reflect the viability of essential component systems as well as their contributions to the viability and performance of other component systems and the total system under study. A systems-based derivation of a comprehensive set of performance indicators first requires the identification of essential component systems, their mutual (often hierarchical or reciprocal relationships, and their contributions to the performance of other component systems and the total system. The second step consists of identifying the indicators that represent the viability states of the component systems and the contributions of these component systems to the performance of the total system. The search for performance indicators is guided by the realization that essential interests (orientations or orientors of systems and actors are shaped by both their characteristic functions and the fundamental and general properties of their system environments (e.g., normal environmental state, scarcity of resources, variety, variability, change, other coexisting systems. To be viable, a system must devote an essential minimum amount of attention to satisfying the "basic orientors" that respond to the properties of its environment. This fact can be used to define comprehensive and system-specific sets of performance indicators that reflect all important concerns. Often, qualitative indicators and the study of qualitative systems are sufficient for reliable performance assessments. However, this approach can also be formalized for quantitative computer-assisted assessment. Examples are presented of indicator sets for the sustainable development of

  11. Distribution and dosimetry of 111In DTPA-D-Phe-octreotide in man assessed by whole body scintigraphy

    International Nuclear Information System (INIS)

    Bajc, M.; Palmer, J.; Ohlsson, T.; Edenbrandt, L.

    1994-01-01

    The distribution and dosimetry of the somatostatin analog 111 In-DTPA-octreotide was evaluated in 6 patients. Whole body scintigraphy in anterior and posterior projections was performed 0.5, 5, 24 and 48 hours after injection. Region-of-interest analysis for different organs and the whole body was used to determine 111 In octreotide half-life-corrected uptake in absolute and relative terms. A rapid initial uptake was seen in the kidneys (2-7%), the spleen (2-6%) and in the liver (4-8%). A lower uptake was seen in the pituitary gland (maximum 0.3%), the thyroid (maximum 0.07%), in the female breast (maximum 1.2%), in the urinary bladder and in the intestinal tract. The elimination pattern varied between different organs. The effective dose equivalent was evaluated to be in the range 0.08 to 0.13 mSv/MBq (average 0.10 mSv/MBq). The behavior of 111 In-DTPA-octreotide suggests follow-up scintigraphy in a period extending up to at least 24 hours after injection. (orig.)

  12. Gd-DTPA enhanced MRI of the brain infarction: correlation between onset of infarction and enhancing patterns

    International Nuclear Information System (INIS)

    Joo, An Young; Kim, Myung Soon; Lee, Sung Soo

    1994-01-01

    To evaluate the correlation between onset of brain infarction and Gd-DTPA enhancing patterns on MRI. We reviewed MRI of 58 lesions in 45 patients with clinically documented brain infarction retrospectively. Axial, coronal and sagittal T1WI (TR/TE 450-520/20), T2WI (TR/TE 2190/90) and Gd-DTPA enhanced T1WI were performed with a 0.5T superconductive MR system. We analyzed Gd-enhancing patterns that were divided into intravascular, meningeal, and parenchymal enhancement. Parenchymal pattern was subdivided into mottled, partial ring like and dense enhancement. Intravascular enhancement was seen at 1-10 days in 30(53%) of 58 infarctions. Meningeal enhancement (13%) was noted at 1-6 days. Parenchymal enhancement (50%) was seen at 2-28 days and subdividing patterns are as follows: The mottled enhancement pattern was seen earlier at 2-8 days and partial ring like or dense enhancement patterns at 5-28 days. After reviewing Gd-enhanced MRI of infarction, the intravascular and meningeal enhancement patterns were earlier than parenchymal enhancement. Among parenchymal patterns, the mottled pattern was seen earlier than partial ring like or dense patterns. In conclusion, Gd-enhancing patterns of brain infarction are useful in estimating the age of infarction including acute infarction

  13. Communication between cochlear perilymph and cerebrospinal fluid through the cochlear modiolus visualized after intratympanic administration of Gd-DTPA

    International Nuclear Information System (INIS)

    Naganawa, Shinji; Satake, Hiroko; Iwano, Shingo; Sone, Michihiko; Nakashima, Tsutomu

    2008-01-01

    Intratympanic injection of gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) has been reported as a procedure to visualize endolymphatic hydrops of Meniere's disease. We frequently noted that cerebrospinal fluid (CSF) in the internal auditory canal (IAC) was also enhanced after this procedure. The purpose of this study was to evaluate how frequently this occurs and to investigate the specific features of patients who lack this communication. A total of 25 patients with clinically suspected endolymphatic hydrops underwent the procedure. After 24 h, three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) and 3D constructive interference in steady state (3D-CISS) were performed. The presence of contrast enhancement in the CSF space of the fundus of the IAC was evaluated. The contrast ratio between CSF of the IAC fundus and cerebellar white matter on the injected side was 1.49±0.65, and that of the noninjected side was 0.32±0.16 (P<0.01). Enhancement of the CSF space in the IAC fundus was seen in all but two subjects: one had enlarged endolymphatic duct and sac syndrome (EEDS), and the other had cochlear nerve agenesis. In these two patients, the cochlear modiolus seemed to be normal. Intratympanic Gd-DTPA administration can reveal permeability of the modiolus and might facilitate evaluation of functional abnormalities of the modiolus not detected by conventional imaging tests. (author)

  14. Dural invasion of meningiomas adjacent to the tumor margin on Gd-DTPA-enhanced MR images: histopathologic correlation

    International Nuclear Information System (INIS)

    Hutzelmann, A.; Palmie, S.; Freund, M.; Heller, M.; Buhl, R.

    1998-01-01

    In intracranial meningiomas a flat, contrast-enhancing, dural structure adjacent to the tumor can occasionally be observed on gadolinium-DTPA-enhanced MR images. We wished to evaluate whether there is a correlation between MR images and meningeal invasion of intracranial meningiomas. The study included 54 patients with intracranial meningioma and the meningeal sign. MR studies included T2-weighted and gadolinium-DTPA-enhanced T1-weighted images in axial, coronal, and sagittal planes. Histopathologic examinations were done on the meningiomas adjacent to the dura mater. The meningeal sign on MRI was observed from 2 up to 35 mm from the main tumor mass in 31 (57 %) of the 54 patients. In 20 of these 31 the histopathologic examination showed tumor invasion, while 11 patients had no tumor invasion but tissue proliferation, hypervascularity, and vascular dilatation. Seven of the 23 meningiomas without the meningeal sign had histologically proven infiltration of the adjacent dura. MR imaging is not able to determine definitive whether or not there is dural infiltration of the meningiomas. In conclusion, resection of the tumor with a wide margin is necessary to achieve complete excision of meningioma and to avoid recurrence. (orig.)

  15. Research progress in muscle-derived stem cells: Literature retrieval results based on international database.

    Science.gov (United States)

    Zhang, Li; Wang, Wei

    2012-04-05

    not in the ClinicalTrials.gov database. (b) We excluded clinical trials that dealt with stem cells other than MDSCs in the ClinicalTrials.gov database. (1) Type of literature; (2) annual publication output; (3) distribution according to journals; (4) distribution according to country; (5) distribution according to institution; (6) top cited authors over the last 10 years; (7) projects financially supported by the NIH; and (8) clinical trials registered. (1) In all, 802 studies on MDSCs appeared in the Web of Science from 2002 to 2011, almost half of which derived from American authors and institutes. The number of studies on MDSCs has gradually increased over the past 10 years. Most papers on MDSCs appeared in journals with a particular focus on cell biology research, such as Experimental Cell Research, Journal of Cell Science, and PLoS One. (2) Eight MDSC research projects have received over US$6 billion in funding from the NIH. The current project led by Dr. Johnny Huard of the University of Pittsburgh-"Muscle-Based Tissue Engineering to Improve Bone Healing"-is supported by the NIH. Dr. Huard has been the most productive and top-cited author in the field of gene therapy and adult stem cell research in the Web of Science over last 10 years. (3) On ClinicalTrials.gov, "Muscle Derived Cell Therapy for Bladder Exstrophy Epispadias Induced Incontinence" Phase 1 is registered and sponsored by Johns Hopkins University and has been led by Dr. John P. Gearhart since November 2009. From our analysis of the literature and research trends, we found that MDSCs may offer further benefits in regenerative medicine.

  16. Comparison of Cloud Base Height Derived from a Ground-Based Infrared Cloud Measurement and Two Ceilometers

    Directory of Open Access Journals (Sweden)

    Lei Liu

    2015-01-01

    Full Text Available The cloud base height (CBH derived from the whole-sky infrared cloud-measuring system (WSIRCMS and two ceilometers (Vaisala CL31 and CL51 from November 1, 2011, to June 12, 2012, at the Chinese Meteorological Administration (CMA Beijing Observatory Station are analysed. Significant differences can be found by comparing the measurements of different instruments. More exactly, the cloud occurrence retrieved from CL31 is 3.8% higher than that from CL51, while WSIRCMS data shows 3.6% higher than ceilometers. More than 75.5% of the two ceilometers’ differences are within ±200 m and about 89.5% within ±500 m, while only 30.7% of the differences between WSIRCMS and ceilometers are within ±500 m and about 55.2% within ±1000 m. These differences may be caused by the measurement principles and CBH retrieval algorithm. A combination of a laser ceilometer and an infrared cloud instrument is recommended to improve the capability for determining cloud occurrence and retrieving CBHs.

  17. A DSL-based Approach to Product Derivation for Software Product Line

    Directory of Open Access Journals (Sweden)

    Nesrine Lahiani

    2016-12-01

    Full Text Available Product derivation is an important part of the Software Product Line (SPL development process. The quality of a product derivation process has a direct impact in decreasing software product costs and time-to-market. In this paper, we present an approach that represents the SPL with a set of integrated models and automatically derives executable products with model transformations. We combine SPL and Model-Driven Engineering (MDE into a comprehensive and extremely effective framework in order to get advantages of both techniques. In order to evaluate the feasibility of our approach, we have designed and implemented it using existing and available technologies.

  18. Synthesis, Characterization, X-ray Crystallography, Acetyl Cholinesterase Inhibition and Antioxidant Activities of Some Novel Ketone Derivatives of Gallic Hydrazide-Derived Schiff Bases

    Directory of Open Access Journals (Sweden)

    Hamid Khaledi

    2012-02-01

    Full Text Available Alzheimer’s disease (AD is the most common form of dementia among older people and the pathogenesis of this disease is associated with oxidative stress. Acetylcholinesterase inhibitors with antioxidant activities are considered potential treatments for AD. Some novel ketone derivatives of gallic hydrazide-derived Schiff bases were synthesized and examined for their antioxidant activities and in vitro and in silico acetyl cholinesterase inhibition. The compounds were characterized using spectroscopy and X-ray crystallography. The ferric reducing antioxidant power (FRAP and 2,2-diphenyl-1-picrylhydrazyl (DPPH assays revealed that all the compounds have strong antioxidant activities. N-(1-(5-bromo-2-hydroxyphenyl-ethylidene-3,4,5-trihydroxybenzohydrazide (2 was the most potent inhibitor of human acetyl cholinesterase, giving an inhibition rate of 77% at 100 μM. Molecular docking simulation of the ligand-enzyme complex suggested that the ligand may be positioned in the enzyme’s active-site gorge, interacting with residues in the peripheral anionic subsite (PAS and acyl binding pocket (ABP. The current work warrants further preclinical studies to assess the potential for these novel compounds for the treatment of AD.

  19. Synthesis of New Chiral Ligands Based on Thiophene Derivatives for Use in Catalytic Asymmetric Oxidation of Sulfides

    International Nuclear Information System (INIS)

    Jeong, Yong Chul; Ahn, Dae Jun; Lee, Woo Sun; Lee, Seung Han; Ahn, Kwang Hyun

    2011-01-01

    We discovered that the vanadium complexes of new Schiff base ligands and prepared from thiophene derivatives efficiently catalyze the asymmetric oxidation of sulfides by hydrogen peroxide to provide sulfoxides with enantioselectivities up to 79% ee and in yields up to 89%. Notably, Schiff base showed better or similar enantioselectivity than the well-studied Schiff base. These results suggest possible applications of Schiff bases derived from and in other catalytic asymmetric reactions. Chiral sulfoxides are important functional groups for various applications. For example, the biological activities of sulfoxide containing drugs such as omeprazole are strongly related to the chirality of the sulfoxide group; for this reason, esomeprazole, the enantiomerically pure form of omeprazole, was later developed. There are several chiral sulfoxide based drugs that have been introduced by the pharmaceutical industry including armodafinil, aprikalim, oxisurane, and ustiloxin. Chiral sulfoxides have also been utilized as chiral auxiliaries in asymmetric syntheses of chiral intermediates

  20. Derived Intervention Levels for Tritium Based on Food and Drug Administration Methodology

    International Nuclear Information System (INIS)

    Blanchard, A.

    1998-01-01

    In 1998, the FDA released it recommendations for age-dependent derived intervention levels for several radionuclides involved in nuclear accidents. One radionuclide that is not included in that document is tritium

  1. Copula-based assimilation of radar and gauge information to derive bias-corrected precipitation fields

    Directory of Open Access Journals (Sweden)

    S. Vogl

    2012-07-01

    Full Text Available This study addresses the problem of combining radar information and gauge measurements. Gauge measurements are the best available source of absolute rainfall intensity albeit their spatial availability is limited. Precipitation information obtained by radar mimics well the spatial patterns but is biased for their absolute values.

    In this study copula models are used to describe the dependence structure between gauge observations and rainfall derived from radar reflectivity at the corresponding grid cells. After appropriate time series transformation to generate "iid" variates, only the positive pairs (radar >0, gauge >0 of the residuals are considered. As not each grid cell can be assigned to one gauge, the integration of point information, i.e. gauge rainfall intensities, is achieved by considering the structure and the strength of dependence between the radar pixels and all the gauges within the radar image. Two different approaches, namely Maximum Theta and Multiple Theta, are presented. They finally allow for generating precipitation fields that mimic the spatial patterns of the radar fields and correct them for biases in their absolute rainfall intensities. The performance of the approach, which can be seen as a bias-correction for radar fields, is demonstrated for the Bavarian Alps. The bias-corrected rainfall fields are compared to a field of interpolated gauge values (ordinary kriging and are validated with available gauge measurements. The simulated precipitation fields are compared to an operationally corrected radar precipitation field (RADOLAN. The copula-based approach performs similarly well as indicated by different validation measures and successfully corrects for errors in the radar precipitation.

  2. Expressions of pathologic markers in PRP based chondrogenic differentiation of human adipose derived stem cells.

    Science.gov (United States)

    Pakfar, Arezou; Irani, Shiva; Hanaee-Ahvaz, Hana

    2017-02-01

    Optimization of the differentiation medium through using autologous factors such as PRP is of great consideration, but due to the complex, variable and undefined composition of PRP on one hand and lack of control over the absolute regulatory mechanisms in in vitro conditions or disrupted and different mechanisms in diseased tissue microenvironments in in vivo conditions on the other hand, it is complicated and rather unpredictable to get the desired effects of PRP making it inevitable to monitor the possible pathologic or undesired differentiation pathways and therapeutic effects of PRP. Therefore, in this study the probable potential of PRP on inducing calcification, inflammation and angiogenesis in chondrogenically-differentiated cells was investigated. The expressions of chondrogenic, inflammatory, osteogenic and angiogenic markers from TGFβ or PRP-treated cells during chondrogenic differentiation of human adipose-derived stem cells (ADSCs) was evaluated. Expressions of Collagen II (Col II), Aggrecan, Sox9 and Runx2 were quantified using q-RT PCR. Expression of Col II and X was investigated by immunocytochemistry as well. Glycosaminoglycans (GAGs) production was also determined by GAG assay. Possible angiogenic/inflammatory potential was determined by quantitatively measuring the secreted VEGF, TNFα and phosphorylated VEGFR2 via ELISA. In addition, the calcification of the construct was monitored by measuring ALP activity and calcium deposition. Our data showed that PRP positively induced chondrogenesis; meanwhile the secretion of angiogenic and inflammatory markers was decreased. VEGFR2 phosphorylation and ALP activity had a decreasing trend, but tissue mineralization was enhanced upon treating with PRP. Although reduction in inflammatory/angiogenic potential of the chondrogenically differentiated constructs highlights the superior effectiveness of PRP in comparison to TGFβ for chondrogenic differentiation, yet further improvement of the PRP-based

  3. Diet index-based and empirically derived dietary patterns are associated with colorectal cancer risk.

    Science.gov (United States)

    Miller, Paige E; Lazarus, Philip; Lesko, Samuel M; Muscat, Joshua E; Harper, Gregory; Cross, Amanda J; Sinha, Rashmi; Ryczak, Karen; Escobar, Gladys; Mauger, David T; Hartman, Terryl J

    2010-07-01

    Previous studies have derived patterns by measuring compliance with preestablished dietary guidance or empirical methods, such as principal components analysis (PCA). Our objective was to examine colorectal cancer risk associated with patterns identified by both methods. The study included 431 incident colorectal cancer cases (225 men, 206 women) and 726 healthy controls (330 men, 396 women) participating in a population-based, case-control study. PCA identified sex-specific dietary patterns and the Healthy Eating Index-2005 (HEI-05) assessed adherence to the 2005 Dietary Guidelines for Americans. A fruits and vegetables pattern and a meat, potatoes, and refined grains pattern were identified among men and women; a third pattern (alcohol and sweetened beverages) was identified in men. The fruits and vegetables pattern was inversely associated with risk among men [odds ratio (OR) = 0.38, 95% CI = 0.21-0.69 for the highest compared with the lowest quartile] and women (OR = 0.35, 95% CI = 0.19-0.65). The meat, potatoes, and refined grains pattern was positively associated with risk in women (OR = 2.20, 95% CI = 1.08-4.50) and there was a suggestion of a positive association among men (OR = 1.56, 95% CI = 0.84-2.90; P-trend = 0.070). Men and women with greater HEI-05 scores had a significantly reduced risk of colorectal cancer (OR = 0.56, 95% CI = 0.31-0.99; OR = 0.44, 95% CI = 0.24-0.77, respectively). Following the Dietary Guidelines or a dietary pattern lower in meat, potatoes, high fat, and refined foods and higher in fruits and vegetables may reduce colorectal cancer risk.

  4. Effective Five Directional Partial Derivatives-Based Image Smoothing and a Parallel Structure Design.

    Science.gov (United States)

    Choongsang Cho; Sangkeun Lee

    2016-04-01

    Image smoothing has been used for image segmentation, image reconstruction, object classification, and 3D content generation. Several smoothing approaches have been used at the pre-processing step to retain the critical edge, while removing noise and small details. However, they have limited performance, especially in removing small details and smoothing discrete regions. Therefore, to provide fast and accurate smoothing, we propose an effective scheme that uses a weighted combination of the gradient, Laplacian, and diagonal derivatives of a smoothed image. In addition, to reduce computational complexity, we designed and implemented a parallel processing structure for the proposed scheme on a graphics processing unit (GPU). For an objective evaluation of the smoothing performance, the images were linearly quantized into several layers to generate experimental images, and the quantized images were smoothed using several methods for reconstructing the smoothly changed shape and intensity of the original image. Experimental results showed that the proposed scheme has higher objective scores and better successful smoothing performance than similar schemes, while preserving and removing critical and trivial details, respectively. For computational complexity, the proposed smoothing scheme running on a GPU provided 18 and 16 times lower complexity than the proposed smoothing scheme running on a CPU and the L0-based smoothing scheme, respectively. In addition, a simple noise reduction test was conducted to show the characteristics of the proposed approach; it reported that the presented algorithm outperforms the state-of-the art algorithms by more than 5.4 dB. Therefore, we believe that the proposed scheme can be a useful tool for efficient image smoothing.

  5. Electron Beam Lithography Using Highly Sensitive Negative Type of Plant-Based Resist Material Derived from Biomass on Hardmask Layer

    Science.gov (United States)

    Takei, Satoshi; Oshima, Akihiro; Sekiguchi, Atsushi; Yanamori, Naomi; Kashiwakura, Miki; Kozawa, Takahiro; Tagawa, Seiichi

    2011-10-01

    We investigated electron beam (EB) lithography using a novel highly sensitive negative type of plant-based resist material derived from biomass on a hardmask layer for trilayer processes. The chemical design concept for using the plant-based resist material with glucose and dextrin derivatives was first demonstrated in the EB lithography. The 1 µm line patterning images with highly efficient crosslinking properties and low film thickness shrinkage were provided under specific process conditions of EB lithography. The results shown reveal that the alpha-linked disaccharide formed by a 1,1-glucoside bond between two glucose units in dextrin derivatives was an important factor in controlling the highly sensitive EB patterning and developer properties.

  6. Synthesis and evaluation of phenylalanine-derived trifluoromethyl ketones for peptide-based oxidation catalysis.

    Science.gov (United States)

    Featherston, Aaron L; Miller, Scott J

    2016-10-15

    We report the synthesis of phenylalanine-derived trifluoromethyl ketones for the in situ generation of dioxiranes for the purpose of oxidation catalysis. The key features of this synthesis include the use of a masked ketone strategy and a Negishi cross-coupling to access the parent amino acid. The derivatives can be readily incorporated into a peptide for use in oxidation chemistry and exhibit good stability and reactivity. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. The correlation between effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) with renal scintigraphy 99mTc-DTPA study

    Science.gov (United States)

    Ratnasari, D.; Nazir, F.; Toresano, L. O. H. Z.; Pawiro, S. A.; Soejoko, D. S.

    2016-03-01

    The prevalence of chronic renal diseases in Indonesia has an increasing annual trend, because it is frequently unrecognized and often co-exists with other disease. GFR and ERPF are parameters currently utilized to estimate renal function at routine renal scintigraphy 99m-Tc DTPA study. This study used 99m-Tc DTPA to measure GFR and ERPF. The purpose of this study was to find the correlation between ERPF and GFR, for ERPF analysis with Schlegel's method, and GFR analysis with Gate's method, as well as to find correction factor between both variables. Analysis of renal scintigraphy has been performed at Department of Nuclear Medicine Pertamina Center Hospital to thirty patient images acquired from 2014 to 2015 which were analyzed retrospectively data, using gamma camera dual head with counting method from renal scintigraphy 99m-Tc DTPA study. The calculation was executed by means of both display and manual calculation. Pearson's statistical analysis resulted on Positive Correlation for all data, with ERPF and GFR (display) showing Strongly Positive Correlation (r = 0.82; p- value < 0.05). Standard deviation was found to be 27.58 and 107.64 for GFR and ERPF (display), respectively. Our result indicated that the use of 99mTc-DTPA measure ERPF was not recommended.

  8. Enrichment of rare-earth elements (REE) and Gd-DTPA in surface water samples by means of countercurrent chromatography (CCC)

    International Nuclear Information System (INIS)

    Hennebrueder, Kristina; Engewald, Werner; Staerk, Hans-Joachim; Wennrich, Rainer

    2005-01-01

    An analytical scheme was developed for the determination of rare-earth elements and gadolinium diethylenetriaminepentaacetate (Gd-DTPA) in river water by ICP-MS. Since the concentration of Gd-DTPA and the rare-earth elements in river water is often lower than the limits of detection in quadrupole ICP-MS applying pneumatic nebulization, a preconcentration procedure is essential. In this work, the capabilities of countercurrent chromatography (CCC) for preconcentration of REE were investigated. For preconcentration ethylhexylphosphates as stationary phase had been used. Acidified aqueous samples (pH 2) and river water spiked with REE and Gd-DTPA were under study. The procedure was compared with solid phase extraction (SPE) using the same samples and ethylhexylphosphates as stationary phase. The recovery of the light and middle REE was found to be at about 100%, which was found to be more efficient than applying SPE. In contrast, the recovery rates for Yb and Lu were low (and poorly reproducible) using CCC (57% and 73%, respectively) while significant better results were obtained with SPE (89% and 84%, respectively). The recoveries of Gd applying Gd-DTPA were 80 ± 4% in the investigation of river water samples

  9. Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese Infants

    Directory of Open Access Journals (Sweden)

    Pei-Lan Shao

    2011-06-01

    Full Text Available Immunogenicity and reactogenicity of the combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (Hib conjugate vaccine (DTPa-IPV/Hib, Infanrix™-IPV + Hib was assessed when co-administered with hepatitis B (HBV vaccine. Seventy healthy infants received DTPa-IPV/Hib at 1.5, 3.5, 6 and 15–18 months, and HBV at birth, 1.5, 6 and 15–18 months of age. Serological responses were assessed. Diphtheria, tetanus, Hib and pertussis seroprotection/seropositivity rates were 100% after primary vaccination. Post-primary immune responses to poliovirus could not be evaluated for technical reasons. However, after the booster dose, seroprotection/seropositivity rates, including poliovirus, were 100%. Over 95% were seroprotected against HBV. Post-booster geometric mean antibody concentrations/titers (GMC/GMTs rose from 14-fold to 45-fold, indicating effective priming against all antigens, including polioviruses. DTPa-IPV/Hib was well tolerated alone or co-administered with HBV. No serious adverse events were considered related to vaccination. Primary and booster vaccination with combined DTPa-IPV/Hib and HBV was immunogenic and well tolerated. Combination vaccines enable vaccine providers to conveniently provide routine pediatric immunizations, with minimal discomfort.

  10. Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance

    DEFF Research Database (Denmark)

    Gutte, Henrik; Møller, Michael L; Pfeifer, Andreas K

    2010-01-01

    study was to evaluate the accuracy of this non-invasive method in children. We calculated GFR from (99m)Tc-diethylene triamine pentaacetic acid (DTPA) renography and compared with (51)Cr-EDTA plasma clearance of 29 children between the age of 1 month and 12 years (mean 4.7 years). The correlation...

  11. Relationship between severity of clinical symptoms and delay in gastric emptying in chronic gastritis; studied with sup(99m)Tc-DTPA scintigraphy

    International Nuclear Information System (INIS)

    Rocha, A.F.G. da; Zuccaro, A.M.; Marquiotti, M.

    1986-01-01

    The gastric emptying time is studied with sup(99m)TC-DTPA-labeled mixed meal in 18 patients with chronic gastritis, all confirmed by endoscopic examination and biopsy. Emptying was slow in all such patients, but the intensity of symptomatology showed no correlation with gastric emptying half time. (orig.)

  12. Comparisons of labeling efficiency, biological activity and biodistribution among /sup 125/I, /sup 67/Ga-DTPA- and /sup 67/Ga-DFO-lectins

    Energy Technology Data Exchange (ETDEWEB)

    Kojima, Shuji; Jay, M.

    1987-10-01

    The labeling efficiency, biological activity and biodistribution of /sup 125/I labeled and /sup 67/Ga chelating agent conjugated lectins were investigated. Pisum sativum agglutinin (PSA) and Lens culinaris agglutinin (LCH) were efficiently labeled with /sup 67/Ga using bifunctional chelating agents such as diethylenetriaminepentaacetic acid (DTPA) and deferoxamine (DFO), whereas labeling with /sup 125/I was significantly less efficient. The agglutinating activity of these lectins towards Ehrlich ascites tumor (EAT) cells was retained on conjugation with DFO, but not with DTPA. The in vitro binding ratio of /sup 67/Ga-DFO-lectins for EAT cells was almost the same as that of /sup 125/I-lectins. However, the value was significantly decreased in the case of /sup 67/Ga-DTPA-lectins. In the biodistribution study of radiolabeled lectins in Ehrlich solid tumor (EST) bearing mice, the accumulation of radioactivity in tumor tissue was very much less with /sup 67/Ga-DTPA-lectins than with /sup 125/I-lectins. However, the concentration was significantly elevated in the case of /sup 67/Ga-DFO-lectins. While, these lectins accumulated in liver, spleen, lung, and kidney to a greater extent than /sup 67/Ga citrate, the tumor to organ ratios became very low. These low tumor to organ ratios, in contrast to /sup 67/Ga citrate, will certainly inhibit the tumor delineation, and therefore it seems that in spite of a high accumulation ratio of /sup 67/Ga-DFO-lectins in tumor tissue, these agents are not useful in tumor detection.

  13. Comparisons of labeling efficiency, biological activity and biodistribution among 125I, 67Ga-DTPA- and 67Ga-DFO-lectins

    International Nuclear Information System (INIS)

    Kojima, Shuji; Jay, M.

    1987-01-01

    The labeling efficiency, biological activity and biodistribution of 125 I labeled and 67 Ga chelating agent conjugated lectins were investigated. Pisum sativum agglutinin (PSA) and Lens culinaris agglutinin (LCH) were efficiently labeled with 67 Ga using bifunctional chelating agents such as diethylenetriaminepentaacetic acid (DTPA) and deferoxamine (DFO), whereas labeling with 125 I was significantly less efficient. The agglutinating activity of these lectins towards Ehrlich ascites tumor (EAT) cells was retained on conjugation with DFO, but not with DTPA. The in vitro binding ratio of 67 Ga-DFO-lectins for EAT cells was almost the same as that of 125 I-lectins. However, the value was significantly decreased in the case of 67 Ga-DTPA-lectins. In the biodistribution study of radiolabeled lectins in Ehrlich solid tumor (EST) bearing mice, the accumulation of radioactivity in tumor tissue was very much less with 67 Ga-DTPA-lectins than with 125 I-lectins. However, the concentration was significantly elevated in the case of 67 Ga-DFO-lectins. While, these lectins accumulated in liver, spleen, lung, and kidney to a greater extent than 67 Ga citrate, the tumor to organ ratios became very low. These low tumor to organ ratios, in contrast to 67 Ga citrate, will certainly inhibit the tumor delineation, and therefore it seems that in spite of a high accumulation ratio of 67 Ga-DFO-lectins in tumor tissue, these agents are not useful in tumor detection. (orig.)

  14. Gd-EOB-DTPA-enhanced MRI for monitoring future liver remnant function after portal vein embolization and extended hemihepatectomy: A prospective trial

    Energy Technology Data Exchange (ETDEWEB)

    Geisel, Dominik; Raabe, Philip; Hamm, Bernd; Denecke, Timm [Charite Campus Virchow-Klinikum, Department of Diagnostic and Interventional Radiology, Berlin (Germany); Luedemann, Lutz [Essen University Hospital, Department of Medical Physics, Essen (Germany); Malinowski, Maciej; Stockmann, Martin; Seehofer, Daniel; Pratschke, Johann [Charite Campus Virchow-Klinikum, Department of General, Visceral and Transplantation Surgery, Berlin (Germany)

    2017-07-15

    To evaluate changes in liver function after right portal vein embolization (PVE) and extended right hemihepatectomy using gadolinium ethoxybenzyl-DTPA-enhanced (Gd-EOB-DTPA) MRI. In this prospective trial, 37 patients undergoing PVE were examined before and 14 and 28 days after PVE and 10 days after extended hemihepatectomy using Gd-EOB-DTPA-enhanced MRI. Lobar volume, kinetic growth rate (KGR), relative enhancement (RE) as well as hepatocellular uptake index (HUI) and fat signal fraction (FSF) were calculated for each lobe. RE of the left liver lobe (LLL) was steadily increasing after PVE and decreased to 0.48 ± 0.19 10 days after surgery, which is significantly lower than 14 days and 28 days post PVE (P < 0.05). KGR was 14.06 ± 9.82%/week for the period from PVE to 14 days after PVE. HUI of the LLL increased steadily after PVE and was significantly higher at both 14 and 28 days after PVE compared to pre PVE (P < 0.05). HUI of the residual liver after surgery was lower than before. Gd-EOB-DTPA-enhanced MRI may be used to monitor the functional increase in the FLR after PVE and to depict the intraoperative liver injury leading to a decrease in liver remnant function. (orig.)

  15. Preparation and preliminary biological evaluation of radiogallium-labeled DTPA-amlodipine complex for possible L-type calcium channel imaging

    Energy Technology Data Exchange (ETDEWEB)

    Firuzyar, Tahereh; Shafiee-Ardestani, Mehdi; Khalaj, Ali [Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of). Faculty of Pharmacy; Jalilian, Amir R.; Fazaeli, Yousef; Aboudzadeh, Mohammad Reza [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of). Radiopharmacy Research Group

    2014-07-01

    A DTPA-conjugated amlodipine analog (DTPA-AMLO) 3, was prepared for possible voltage gated calcium channel imaging after radiolabeling with Ga-67. [{sup 67}Ga]-DTPA-AMLO complex was prepared starting [{sup 67}Ga]gallium chloride and DTPA-AMLO in 60-90 min at 50-60 C in phosphate buffer. The partition co-efficient and stability of the tracer was determined in final solution (25 C) and presence of human serum (37 C) up to 24 h. The biodistribution of the labeled compound in wild-type rats were determined up to 72 h using organ counting and SPECT. The radiolabled complex was prepared in high radiochemical purity (>96%, RTLC and >98% HPLC) and significant specific activity (7-10 GBq/mmol). The log P for the complex was calculated as -0.594, consistent with a water soluble complex. The tracer is mostly washed out through kidneys which were in full compliance with the amlodipine metabolism and imaging studies demonstrated the same behavior. The tracer uptake in organs with smooth muscles was observed in stomach, colon as well as intestine.

  16. Decontaminating effectiveness of Ca-, Zn-, MnDTPA chelates in contamination with inner radioisotopes 137Cs, 144Ce, 131I, 90Sr

    International Nuclear Information System (INIS)

    Kossakowski, S.

    1987-01-01

    The studies were carried out on 240 rabbits divided into 4 groups, in which, after contamination with radioisotopes 137 Cs (A), 144 Ce (B), 131 I (C), 90 Sr (D), Ca-, Zn-, MnDTPA chelates were used in 12.5% water solutions in doses of 0.4 g/kg of body weight. The evaluation of the decontaminating effectiveness of the above DTPA compounds, taking into account veterinary-clinical and veterinary-sanitary aspects, was made after 1,2,4,6,15 days from the contamination. The results expressing the per cent values of radioactivity of the organs are presented in individual groups. From these data it can be assumed for practical veterinary purposes that Ca-, Zn-, MnDTPA chelates show an effective action with respect to the veterinary-clinical aspect in contamination with radiocerium and with respect to the veterinary-sanitary aspect in contamination with radiocerium and radioiodine; less effective action with respect to the veterinary-sanitary aspect and ineffective with respect to the veterinary-clinical aspect in contamination with radiocesium; negative one with respect to both aspects in contamination with radiostrontium. As regards the individual chelating compounds, the most effective can be recognized sodium zinc salt of DTPA. 58 refs., 4 tabs. (author)

  17. Can biliary–cyst communication be predicted by Gd-EOB-DTPA-enhanced MR cholangiography before treatment for hepatic hydatid disease?

    International Nuclear Information System (INIS)

    Kantarci, M.; Pirimoglu, B.; Ogul, H.; Bayraktutan, U.; Eren, S.; Aydinli, B.; Ozturk, G.; Karaca, L.

    2014-01-01

    Aim: To evaluate the role of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance cholangiography (MRC) in the evaluation of biliary–cyst communication (BCC) before treatment for hepatic hydatid disease (HHD). Material and methods: Thirty-one patients with clinical and laboratory follow-up for HHD with suspected diagnosis of BCC underwent three-dimensional (3D) T2-weighted MRC and T1-weighted contrast-enhanced MRC, dynamic 3D gradient echo (GRE) sequences, using Gd-EOB-DTPA to identify the presence or absence of BCC. A total of 45 hepatic hydatid cysts in the 31 patients were evaluated for cyst diameter, BCC, and the time to contrast-enhancement of the hydatid cyst after Gd-EOB-DTPA injection. The surgical and interventional radiological procedures and imaging findings were compared. The sensitivity, specificity, and accuracy of both techniques in identification of BCC were calculated. Results: The accuracy of contrast-enhanced MRC for identifying BCC was superior with a sensitivity of 87.4% and accuracy of 90.5% (p < 0.05). A diameter of ≥10 cm was associated with significantly increased risk of BCC on contrast-enhanced MRC images (p < 0.05). Conclusion: The use of Gd-EOB-DTPA-enhanced MRC yields information that complements T2-weighted MRC findings and improves identification of BCC. The use of T2-weighted MRC, in addition to contrast-enhanced MRC, is recommended to increase preoperative accuracy of identifying BCC

  18. 40 CFR Appendix Vii to Part 266 - Health-Based Limits for Exclusion of Waste-Derived Residues*

    Science.gov (United States)

    2010-07-01

    ...-Based Limits for Exclusion of Waste-Derived Residues* Metals—TCLP Extract Concentration Limits...-66-3 6xE−02 Copper cyanide 544-92-3 2xE−01 Cresols (Cresylic acid) 1319-77-3 2xE+00 Cyanogen 460-19-5...

  19. Gastrointestinal transit measurements in mice with 99mTc-DTPA-labeled activated charcoal using NanoSPECT-CT.

    Science.gov (United States)

    Padmanabhan, Parasuraman; Grosse, Johannes; Asad, Abu Bakar Md Ali; Radda, George K; Golay, Xavier

    2013-08-02

    Gastrointestinal (GI) disorders are commonly associated with chronic conditions such as diabetes, obesity, and hypertension. Direct consequences are obstipation or diarrhea as opposite aspects of the irritable bowel syndrome, and more indirectly, alteration of appetite, feeling of fullness, flatulence, bloatedness, and eventually leading to altered absorption of nutrients. Moreover, GI retention and passage times have been recognized as important factors in determining the release site and hence the bioavailability of orally administered drugs. To facilitate the understanding of physiological and pathological processes involved, it is necessary to monitor the gut motility in animal models. Here, we describe a method for studying the GI transit time using technetium-labeled activated charcoal diethylenetriaminepentaacetic acid (99mTc-Ch-DTPA) detected by single-photon emission computed tomography (SPECT). Tc-DTPA was adsorbed onto activated charcoal and administered orally to trypan blue-tainted (n = 4) 129SvEv mice (50 to 80 MBq/animal, n = 11). The exact distribution and movement of radioactivity in the gastrointestinal tract was measured at intervals of 1, 3, 6, 12, and 22 h by SPECT-CT. In addition, in order to validate the imaging of GI transient time, loperamide (0.25 mg/animal, n = 3) was used to delay the GI transit. The transit time measured as the peak radioactivity occurring in the rectum was 6 to 7 h after gavaging of 99mTc-Ch-DTPA. After 1 h, the bolus had passed into the small intestine and entered the cecum and the colon. At 6 and 8 h, the cecum, the ascending, transverse, and descending colon, and the rectum showed significant labeling. Several pellets were stored in the rectum for defecation. After 22 h, little activity remained in the stomach and none was detected in the transverse colon or other GI locations. In contrast, 6 h after administration of loperamide, only the cecum and part of the transverse colon were labeled. After 22 h, both

  20. Evaluation of 99Tcm-DTPA glomerular filtration rate by the Gates method in patients with type 2 diabetes

    International Nuclear Information System (INIS)

    Yuan Jie; Zhang Guangming; Liu Congjin; Wang Yuankai; Zhu Huiqing; Kuai Dayu; Wu Xia; Hu Renming; Liu Xingdang

    2013-01-01

    Objective: To study the changes of GFR measured in different time intervals after the injection of 99 Tc m -DTPA and to evaluate the clinical value of GFR in patients with type 2 diabetes. Methods: Eleven healthy volunteers (6 males, 5 females; mean age (61.45±7.90) years, age range: 47-79 years) and 56 patients with type 2 diabetes (31 males, 25 females; mean age (60.98±6.96) years, age range: 45-75 years) were recruited. 99 Tc m -DTPA was used to measure GFR for all subjects. ROI was drawn at 2 and 3 min post-injection and GFR was calculated by Gates method. Two-sample t test and Pearson correlation analysis were performed with SPSS 15.0. Results: SCr ((84.90±14.38) μmol/L) was significantly correlated with GFR in patients with type 2 diabetes. There was negative correlation between SCr and GFR for both, left and right kidneys at 3 min post-injection (r=-0.652, -0.636, -0.470, all P≤0.001) and at 2 min post-injection (r=-0.599, -0.553, -0.529, all P<0.001). Total GFR, GFR for left kidney and GFR for right kidney at 3 min post-injection in diabetes group ((69.77 ± 11.00),(33.12 ± 5.74), (37.34 ± 9.81) ml/min) were lower than those in control group ((97.89±5.98), (46.60±4.91), (51.28±4.20) ml/min; t=-8.212, -7.233, -4.069, all P<0.001). Conclusions: To calculate the GFR of the patients with type 2 diabetes, 3 min post-injection is the optimal time. Measurement of GFR by 99 Tc m -DTPA is useful in early diagnosis of diabetic nephropathy. (authors)