WorldWideScience

Sample records for based biokinetic pbbk

  1. A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat

    International Nuclear Information System (INIS)

    Punt, Ans; Freidig, Andreas P.; Delatour, Thierry; Scholz, Gabriele; Boersma, Marelle G.; Schilter, Benoit; Bladeren, Peter J. van; Rietjens, Ivonne M.C.M.

    2008-01-01

    The present study defines a physiologically based biokinetic (PBBK) model for the alkenylbenzene estragole in rat based on in vitro metabolic parameters determined using relevant tissue fractions, in silico derived partition coefficients, and physiological parameters derived from the literature. The model consists of eight compartments including liver, lung and kidney as metabolizing compartments, and additional compartments for fat, arterial blood, venous blood, rapidly perfused tissue and slowly perfused tissue. Evaluation of the model was performed by comparing the PBBK predicted dose-dependent formation of the estragole metabolites 4-allylphenol and 1'-hydroxyestragole glucuronide to literature reported levels of these metabolites, which were demonstrated to be in the same order of magnitude. With the model obtained the relative extent of bioactivation and detoxification of estragole at different oral doses was examined. At low doses formation of 4-allylphenol, leading to detoxification, is observed to be the major metabolic pathway, occurring mainly in the lung and kidney due to formation of this metabolite with high affinity in these organs. Saturation of this metabolic pathway in the lung and kidney leads to a relative increase in formation of the proximate carcinogenic metabolite 1'-hydroxyestragole, occurring mainly in the liver. This relative increase in formation of 1'-hydroxyestragole leads to a relative increase in formation of 1'-hydroxyestragole glucuronide and 1'-sulfooxyestragole the latter being the ultimate carcinogenic metabolite of estragole. These results indicate that the relative importance of different metabolic pathways of estragole may vary in a dose-dependent way, leading to a relative increase in bioactiviation of estragole at higher doses

  2. Physiologically based biokinetic (PBBK) modeling and validation of dose-, species-, interindividual- and matrix dependent effects on the bioactivation and detoxification of safrole

    NARCIS (Netherlands)

    Martati, E.

    2013-01-01

    Keywords: safrole, PBBK model, DNA adduct, mace  Safrole has been demonstrated to be carcinogenic in rodent studies at high doses of the pure compound. The use of pure safrole in foodshas already been prohibited. As a result, the main

  3. Structure of a physiologically based biokinetic model for use in 14C and organically bound tritium dosimetry

    International Nuclear Information System (INIS)

    Whillians, D.W.

    2003-01-01

    Physiologically based biokinetic (PBBK) dosimetry models for beta emitters like 3 H and 14 C must include rapid turnover compartments which, while they may be minor in terms of dose commitment, can dominate bioassay measurements at early times after intake. In this paper a consistent PBBK model structure will be described for use in dose assessments for organic 14 C and organically bound tritium (OBT), and also for 14 CO 2 , based on the literature of human carbon metabolism, and on direct measurements of human excretion. CO 2 /HCO 3 - is a central compartment in carbon metabolism. The 14 CO 2 biokinetic model described in ICRP Publication 80 for the calculation of dose coefficients was found to omit early components of excretion necessary for the accurate interpretation of bioassay results. Recommendations on the requirements on dosimetry models for intakes of 14 C and OBT are made. (author)

  4. Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect

    International Nuclear Information System (INIS)

    Alhusainy, W.; Paini, A.; Punt, A.; Louisse, J.; Spenkelink, A.; Vervoort, J.; Delatour, T.; Scholz, G.; Schilter, B.; Adams, T.; Bladeren, P.J. van; Rietjens, I.M.C.M.

    2010-01-01

    Estragole is a natural constituent of several herbs and spices including sweet basil. In rodent bioassays, estragole induces hepatomas, an effect ascribed to estragole bioactivation to 1'-sulfooxyestragole resulting in DNA adduct formation. The present paper identifies nevadensin as a basil constituent able to inhibit DNA adduct formation in rat hepatocytes exposed to the proximate carcinogen 1'-hydroxyestragole and nevadensin. This inhibition occurs at the level of sulfotransferase (SULT)-mediated bioactivation of 1'-hydroxyestragole. The Ki for SULT inhibition by nevadensin was 4 nM in male rat and human liver fractions. Furthermore, nevadensin up to 20 μM did not inhibit 1'-hydroxyestragole detoxification by glucuronidation and oxidation. The inhibition of SULT by nevadensin was incorporated into the recently developed physiologically based biokinetic (PBBK) rat and human models for estragole bioactivation and detoxification. The results predict that co-administration of estragole at a level inducing hepatic tumors in vivo (50 mg/kg bw) with nevadensin at a molar ratio of 0.06, representing the ratio of their occurrence in basil, results in almost 100% inhibition of the ultimate carcinogen 1'-sulfooxyestragole when assuming 100% uptake of nevadensin. Assuming 1% uptake, inhibition would still amount to more than 83%. Altogether these data point at a nevadensin-mediated inhibition of the formation of the ultimate carcinogenic metabolite of estragole, without reducing the capacity to detoxify 1'-hydroxyestragole via glucuronidation or oxidation. These data also point at a potential reduction of the cancer risk when estragole exposure occurs within a food matrix containing SULT inhibitors compared to what is observed upon exposure to pure estragole.

  5. A physiologically based biodynamic (PBBD) model for estragole DNA binding in rat liver based on in vitro kinetic data and estragole DNA adduct formation in primary hepatocytes

    International Nuclear Information System (INIS)

    Paini, Alicia; Punt, Ans; Viton, Florian; Scholz, Gabriele; Delatour, Thierry; Marin-Kuan, Maricel; Schilter, Benoit; Bladeren, Peter J. van; Rietjens, Ivonne M.C.M.

    2010-01-01

    Estragole has been shown to be hepatocarcinogenic in rodent species at high-dose levels. Translation of these results into the likelihood of formation of DNA adducts, mutation, and ultimately cancer upon more realistic low-dose exposures remains a challenge. Recently we have developed physiologically based biokinetic (PBBK) models for rat and human predicting bioactivation of estragole. These PBBK models, however, predict only kinetic characteristics. The present study describes the extension of the PBBK model to a so-called physiologically based biodynamic (PBBD) model predicting in vivo DNA adduct formation of estragole in rat liver. This PBBD model was developed using in vitro data on DNA adduct formation in rat primary hepatocytes exposed to 1'-hydroxyestragole. The model was extended by linking the area under the curve for 1'-hydroxyestragole formation predicted by the PBBK model to the area under the curve for 1'-hydroxyestragole in the in vitro experiments. The outcome of the PBBD model revealed a linear increase in DNA adduct formation with increasing estragole doses up to 100 mg/kg bw. Although DNA adduct formation of genotoxic carcinogens is generally seen as a biomarker of exposure rather than a biomarker of response, the PBBD model now developed is one step closer to the ultimate toxic effect of estragole than the PBBK model described previously. Comparison of the PBBD model outcome to available data showed that the model adequately predicts the dose-dependent level of DNA adduct formation. The PBBD model predicts DNA adduct formation at low levels of exposure up to a dose level showing to cause cancer in rodent bioassays, providing a proof of principle for modeling a toxicodynamic in vivo endpoint on the basis of solely in vitro experimental data.

  6. Molecular Biomarker-Based Biokinetic Modeling of a PCE-Dechlorinating and Methanogenic Mixed Culture

    Energy Technology Data Exchange (ETDEWEB)

    Heavner, Gretchen L. W.; Rowe, Annette R.; Mansfeldt, Cresten B.; Pan, Ju Khuan; Gossett, James M.; Richardson, Ruth E.

    2013-04-16

    Bioremediation of chlorinated ethenes via anaerobic reductive dechlorination relies upon the activity of specific microbial population-most notably Dehalococcoides (DHC) strains. In the lab and field Dehalococcoides grow most robustly in mixed communities which usually contain both fermenters and methanogens. Recently, researchers have been developing quantitative molecular biomarkers to aid in field site diagnostics and it is hoped that these biomarkers could aid in the modeling of anaerobic reductive dechlorination. A comprehensive biokinetic model of a community containing Dehalococcoides mccartyi (formerly D. ethenogenes) was updated to describe continuously fed reactors with specific biomass levels based on quantitative PCR (qPCR)-based population data (DNA and RNA). The model was calibrated and validated with subsets of chemical and molecular biological data from various continuous feed experiments (n = 24) with different loading rates of the electron acceptor (1.5 to 482 μeeq/L-h), types of electron acceptor (PCE, TCE, cis-DCE) and electron donor to electron acceptor ratios. The resulting model predicted the sum of dechlorination products vinyl chloride (VC) and ethene (ETH) well. However, VC alone was under-predicted and ETH was over predicted. Consequently, competitive inhibition among chlorinated ethenes was examined and then added to the model. Additionally, as 16S rRNA gene copy numbers did not provide accurate model fits in all cases, we examined whether an improved fit could be obtained if mRNA levels for key functional enzymes could be used to infer respiration rates. The resulting empirically derived mRNA “adjustment factors” were added to the model for both DHC and the main methanogen in the culture (a Methanosaeta species) to provide a more nuanced prediction of activity. Results of this study suggest that at higher feeding rates competitive inhibition is important and mRNA provides a more accurate indicator of a population’s instantaneous

  7. A simple allometric diffusion-based biokinetic model to predict Cu(II) uptake across gills of freshwater clam Corbicula fluminea.

    Science.gov (United States)

    Chen, W-Y; Lin, C-M; Ju, Y-R; Liao, C-M

    2010-06-01

    The purpose of this study was to link Fick's type mass transfer and biokinetics together with Michaelis-Menten kinetics to arrive at a simple predictive framework for quantifying biouptake mechanisms in gills of freshwater clam Corbicula fluminea exposed to Cu(II). A diffusion-based Cu(II) influx and permeability can be calculated using physiological and allometric-related parameters. Simulations indicate that Cu(II) bioconcentration factor of gills was 42. Estimated steady-state Cu(II) gill uptake influx and permeability were 0.097 nmol cm(-2) s(-1) and 0.48 cm s(-1), respectively. The proposed simple allometric diffusion-based biokinetic model meets the need for describing nonequilibrium aspects of biouptake mechanisms in bivalve gills.

  8. Lead Bioaccumulation Factor of Cockle Shell (Anadara granosa) Base on Biokinetic Study that Used Radiotracer 210Pb

    International Nuclear Information System (INIS)

    Heru Umbara; Heny Suseno

    2007-01-01

    Lead is kind of hazardous heavy metal to human health and the concentration in the coastal environment should be monitored continuously because lead could be accumulated by marine biota. One of the monitoring techniques is bio indicator. Anadara granosa is a marine biota which spread in almost all Indonesian coastal, life in the bottom and mud sandy environment in the depth of until 4 meter and relatively still. Base on the book of environmental equilibrium balance DKI Jakarta, Anadara granosa is a macrozobenthos in Jakarta bay which have second highest density after Donax or with density of 14 individual per meter square. Base on the environmental equilibrium balance from 26 locations, 22 locations can be found Anadara granosa so this mollusk could be used for bio indicator. The objective of research for bioaccumulation that use 210 Pb as a tracer is to find bio indicator base on biokinetic process which include concentration factor, uptake and depuration processes and biology half life. The result shows that Anadara granosa could be use as a lead bio indicator in Jakarta bay. (author)

  9. A physiologically based biokinetic model for cesium in the human body

    International Nuclear Information System (INIS)

    Leggett, R.W.; Williams, L.R.; Melo, D.R.; Lipsztein, J.L.

    2003-01-01

    A physiologically descriptive model of the biological behavior of cesium in the human body has been constructed around a detailed blood flow model. The rate of transfer from plasma into a tissue is determined by the blood perfusion rate and the tissue-specific extraction fraction of Cs during passage from arterial to venous plasma. Information on tissue-specific extraction of Cs is supplemented with information on the Cs analogues, K and Rb, and known patterns of discrimination between these metals by tissues. The rate of return from a tissue to plasma is estimated from the relative contents of Cs in plasma and the tissue at equilibrium as estimated from environmental studies. Transfers of Cs other than exchange between plasma and tissues (e.g. secretions into the gastrointestinal tract) are based on a combination of physiological considerations and empirical data on Cs or related elements. Model predictions are consistent with the sizable database on the time-dependent distribution and retention of radiocesium in the human body

  10. Uranium: biokinetics and toxicity

    International Nuclear Information System (INIS)

    Menetrier, F.; Renaud-Salis, V.; Flury-Herard, A.

    2000-01-01

    This report was achieved as a part of a collaboration with the Fuel Cycle Direction. Its aim was to give the state of the art about: the behaviour of uranium in the human organism (biokinetics) after ingestion, its toxicity (mainly renal) and the current regulation about its incorporation. Both in the upstream and in the downstream of the fuel cycle, uranium remains, quantitatively, the first element in the cycle which is, at the present time, temporarily disposed or recycled. Such a considerable quantity of uranium sets the problem of its risk on the health. In the long term, the biosphere may be affected and consequently the public may ingest water or food contaminated with uranium. In this way, radiological and chemical toxicity risk may be activated. This report emphasizes: the necessity of confirming some experimental and epidemiological biokinetic data used or not in the ICRP models. Unsolved questions remain about the gastrointestinal absorption according to chemical form (valency state, mixtures...), mass and individual variations (age, disease) further a chronic ingestion of uranium. It is well established that uranium is mainly deposited in the skeleton and the kidney. But the skeleton kinetics following a chronic ingestion and especially in some diseases has to be more elucidated; the necessity of taking into account uranium at first as a chemical toxic, essentially in the kidney and determining the threshold of functional lesion. In this way, it is important to look for some specific markers; the problem of not considering chemical toxicity of uranium in the texts regulating its incorporation

  11. Biokinetic models for radionuclides in experimental animals

    International Nuclear Information System (INIS)

    Morcillo, M. A.

    2003-01-01

    The biokinetic models for many radionuclides are, to a large extent, based on data obtained in experimental animals. The methods used in the experimental development of a biokinetic model can be classified in two groups (i) those applied during the experimental work, which include the activity determination of a given radionuclide at different times and in different biological media such as blood, serum, organs/tissues, urine, bile and faeces and (ii) those methods used for the analysis and study of the experimental data, based in mathematical tools. Some of these methods are reviewed,with special emphasis in the whole body macro autoradiography. To conclude, the contribution that this type of studies can have in two fields of radiation protection is discussed, namely optimization of dosimetric evaluations and decorporation of radionuclides. (Author)

  12. A biokinetic model for manganese

    Energy Technology Data Exchange (ETDEWEB)

    Leggett, R.W., E-mail: rwl@ornl.gov

    2011-09-15

    The International Commission on Radiological Protection (ICRP) is updating its biokinetic models used to derive dose coefficients and assess bioassay data for intake of radionuclides. This paper reviews biokinetic data for manganese and proposes a biokinetic model for systemic manganese in adult humans. The proposed model provides a more detailed and physiologically meaningful description of the behavior of absorbed manganese in the body than the current ICRP model. The proposed model and current ICRP model yield broadly similar estimates of dose per unit activity of inhaled or ingested radio-manganese but differ substantially with regard to interpretation of bioassay data. The model is intended primarily for use in radiation protection but can also serve as a baseline model for evaluation of potentially excessive intakes of stable manganese in occupational settings. - Highlights: {yields} Manganese is an essential trace element but a neurotoxin when inhaled excessively. {yields} Manganese-54 is an important radiation hazard in and around nuclear reactors. {yields} Biokinetic data for manganese are reviewed and a new biokinetic model is developed. {yields} The main purpose is to update the manganese model used in radiation protection. {yields} The model can also be applied in evaluations of manganese as a chemical hazard.

  13. A biokinetic model for manganese

    International Nuclear Information System (INIS)

    Leggett, R.W.

    2011-01-01

    The International Commission on Radiological Protection (ICRP) is updating its biokinetic models used to derive dose coefficients and assess bioassay data for intake of radionuclides. This paper reviews biokinetic data for manganese and proposes a biokinetic model for systemic manganese in adult humans. The proposed model provides a more detailed and physiologically meaningful description of the behavior of absorbed manganese in the body than the current ICRP model. The proposed model and current ICRP model yield broadly similar estimates of dose per unit activity of inhaled or ingested radio-manganese but differ substantially with regard to interpretation of bioassay data. The model is intended primarily for use in radiation protection but can also serve as a baseline model for evaluation of potentially excessive intakes of stable manganese in occupational settings. - Highlights: → Manganese is an essential trace element but a neurotoxin when inhaled excessively. → Manganese-54 is an important radiation hazard in and around nuclear reactors. → Biokinetic data for manganese are reviewed and a new biokinetic model is developed. → The main purpose is to update the manganese model used in radiation protection. → The model can also be applied in evaluations of manganese as a chemical hazard.

  14. A biokinetic and dosimetric model for ionic indium in humans

    Science.gov (United States)

    Andersson, Martin; Mattsson, Sören; Johansson, Lennart; Leide-Svegborn, Sigrid

    2017-08-01

    This paper reviews biokinetic data for ionic indium, and proposes a biokinetic model for systemic indium in adult humans. The development of parameter values focuses on human data and indium in the form of ionic indium(III), as indium chloride and indium arsenide. The model presented for systemic indium is defined by five different pools: plasma, bone marrow, liver, kidneys and other soft tissues. The model is based on two subsystems: one corresponding to indium bound to transferrin and one where indium is transported back to the plasma, binds to red blood cell transferrin and is then excreted through the kidneys to the urinary bladder. Absorbed doses to several organs and the effective dose are calculated for 111In- and 113mIn-ions. The proposed biokinetic model is compared with previously published biokinetic indium models published by the ICRP. The absorbed doses are calculated using the ICRP/ICRU adult reference phantoms and the effective dose is estimated according to ICRP Publication 103. The effective doses for 111In and 113mIn are 0.25 mSv MBq-1 and 0.013 mSv MBq-1 respectively. The updated biokinetic and dosimetric models presented in this paper take into account human data and new animal data, which represent more detailed and presumably more accurate dosimetric data than that underlying previous models for indium.

  15. Stable tracer investigations in humans for assessing the biokinetics of ruthenium and zirconium radionuclides

    International Nuclear Information System (INIS)

    Veronese, I.; Cantone, M.C.; Giussani, A.; Maggioni, T.; Birattari, C.; Bondardi, M.; Groppi, F.; Garlaschelli, I.; Werner, E.; Roth, P.; Hoellriegl, V.; Louvat, P.; Felgenhauer, N.; Zilker, Th.

    2003-01-01

    The interest in the biokinetics of ruthenium and zirconium in humans is justified by the potential radiological risk represented by their radionuclides. Only a few data related to the biokinetics of ruthenium and zirconium in humans are available and, accordingly, the biokinetic models currently recommended by the ICRP for these elements are mainly based on data from animal experiments. The use of stable isotopes as tracers, coupled with a proper analytical technique (nuclear activation analysis with protons) for their determination in biological samples, represents an ethically acceptable methodology for biokinetic investigations, being free from any radiation risk for the volunteer subjects. In this work, the results obtained in eight biokinetic investigations for ruthenium, conducted on a total of three healthy volunteers, and six for zirconium, performed on a total of three subjects, are presented and compared to the predictions of the ICRP models. (author)

  16. A biokinetic model for zinc for use in radiation protection

    International Nuclear Information System (INIS)

    Leggett, Richard Wayne

    2012-01-01

    The physiology of the essential trace element zinc has been studied extensively in human subjects using kinetic analysis of time-dependent measurements of administered zinc tracers. A number of biokinetic models describing zinc exchange between plasma and tissues and loss of systemic zinc in excreta have been developed from the derived data. More rudimentary biokinetic models for zinc have been developed to estimate radiation doses from internally deposited radioisotopes of zinc. The latter models are designed to provide broadly accurate estimates of cumulative decays of zinc radioisotopes in tissues and are not intended as realistic descriptions of the directions of movement of zinc in the body. This paper reviews biokinetic data for zinc and proposes a physiologically meaningful biokinetic model for systemic zinc for use in radiation protection. The proposed model bears some resemblance to zinc models developed in physiological studies but depicts a finer division of systemic zinc and is based on a broader spectrum of data than previous models. The proposed model and current radiation protection model for zinc yield broadly similar estimates of effective dose from internally deposited radioisotopes of zinc but substantially different dose estimates for several individual tissues, particularly the liver.

  17. The Effect of Body Size in Mercury Accumulation Biokinetic of Cockle Shell (Anadara Granosa)

    International Nuclear Information System (INIS)

    Wahyu Retno Prihatiningsih

    2007-01-01

    Accumulation of mercury biokinetic in cockle shell (Anadara granosa) through water pathway has been investigated under laboratory condition. The objective of research is to find the effect of body size in mercury biokinetic of Anadara granosa and to find bioindicator based on biokinetic parameter. The research shows that body size of Anadara granosa give an effect to concentration factor and could barrier mercury contaminant. Concentration factor for size 1.9, 2.5 and 3.9 cm of biota moving high and reach steady state condition after 24 days. Concentration factor of Anadara granosa in size 1.9, 2.5 and 3.9 is 0.1476, 0.1645 and 0.2573 day. Based on mechanism of mercury biokinetic process, it was proof that Anadara granosa is an ideal invertebrate for bioindicator. (author)

  18. Towards a consensus-based biokinetic model for green microalgae – The ASM-A

    DEFF Research Database (Denmark)

    Wágner, Dorottya Sarolta; Valverde Pérez, Borja; Sæbø, Mariann

    2016-01-01

    Cultivation of microalgae in open ponds and closed photobioreactors (PBRs) using wastewater resources offers an opportunity for biochemical nutrient recovery. Effective reactor system design and process control of PBRs requires process models. Several models with different complexities have been...... of microalgae. Model parameters were estimated using laboratory-scale batch and sequenced batch experiments using the novel Latin Hypercube Sampling based Simplex (LHSS) method. The model was evaluated using independent data obtained in a 24-L PBR operated in sequenced batch mode. Identifiability of the model...

  19. Towards a consensus-based biokinetic model for green microalgae - The ASM-A.

    Science.gov (United States)

    Wágner, Dorottya S; Valverde-Pérez, Borja; Sæbø, Mariann; Bregua de la Sotilla, Marta; Van Wagenen, Jonathan; Smets, Barth F; Plósz, Benedek Gy

    2016-10-15

    Cultivation of microalgae in open ponds and closed photobioreactors (PBRs) using wastewater resources offers an opportunity for biochemical nutrient recovery. Effective reactor system design and process control of PBRs requires process models. Several models with different complexities have been developed to predict microalgal growth. However, none of these models can effectively describe all the relevant processes when microalgal growth is coupled with nutrient removal and recovery from wastewaters. Here, we present a mathematical model developed to simulate green microalgal growth (ASM-A) using the systematic approach of the activated sludge modelling (ASM) framework. The process model - identified based on a literature review and using new experimental data - accounts for factors influencing photoautotrophic and heterotrophic microalgal growth, nutrient uptake and storage (i.e. Droop model) and decay of microalgae. Model parameters were estimated using laboratory-scale batch and sequenced batch experiments using the novel Latin Hypercube Sampling based Simplex (LHSS) method. The model was evaluated using independent data obtained in a 24-L PBR operated in sequenced batch mode. Identifiability of the model was assessed. The model can effectively describe microalgal biomass growth, ammonia and phosphate concentrations as well as the phosphorus storage using a set of average parameter values estimated with the experimental data. A statistical analysis of simulation and measured data suggests that culture history and substrate availability can introduce significant variability on parameter values for predicting the reaction rates for bulk nitrate and the intracellularly stored nitrogen state-variables, thereby requiring scenario specific model calibration. ASM-A was identified using standard cultivation medium and it can provide a platform for extensions accounting for factors influencing algal growth and nutrient storage using wastewater resources. Copyright

  20. The STATFLUX code: a statistical method for calculation of flow and set of parameters, based on the Multiple-Compartment Biokinetical Model

    Science.gov (United States)

    Garcia, F.; Mesa, J.; Arruda-Neto, J. D. T.; Helene, O.; Vanin, V.; Milian, F.; Deppman, A.; Rodrigues, T. E.; Rodriguez, O.

    2007-03-01

    The code STATFLUX, implementing a new and simple statistical procedure for the calculation of transfer coefficients in radionuclide transport to animals and plants, is proposed. The method is based on the general multiple-compartment model, which uses a system of linear equations involving geometrical volume considerations. Flow parameters were estimated by employing two different least-squares procedures: Derivative and Gauss-Marquardt methods, with the available experimental data of radionuclide concentrations as the input functions of time. The solution of the inverse problem, which relates a given set of flow parameter with the time evolution of concentration functions, is achieved via a Monte Carlo simulation procedure. Program summaryTitle of program:STATFLUX Catalogue identifier:ADYS_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADYS_v1_0 Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland Licensing provisions: none Computer for which the program is designed and others on which it has been tested:Micro-computer with Intel Pentium III, 3.0 GHz Installation:Laboratory of Linear Accelerator, Department of Experimental Physics, University of São Paulo, Brazil Operating system:Windows 2000 and Windows XP Programming language used:Fortran-77 as implemented in Microsoft Fortran 4.0. NOTE: Microsoft Fortran includes non-standard features which are used in this program. Standard Fortran compilers such as, g77, f77, ifort and NAG95, are not able to compile the code and therefore it has not been possible for the CPC Program Library to test the program. Memory required to execute with typical data:8 Mbytes of RAM memory and 100 MB of Hard disk memory No. of bits in a word:16 No. of lines in distributed program, including test data, etc.:6912 No. of bytes in distributed program, including test data, etc.:229 541 Distribution format:tar.gz Nature of the physical problem:The investigation of transport mechanisms for

  1. Preclinical Biokinetic Modelling of Tc-99m Radiophamaceuticals Obtained from Semi-Automatic Image Processing.

    Science.gov (United States)

    Cornejo-Aragón, Luz G; Santos-Cuevas, Clara L; Ocampo-García, Blanca E; Chairez-Oria, Isaac; Diaz-Nieto, Lorenza; García-Quiroz, Janice

    2017-01-01

    The aim of this study was to develop a semi automatic image processing algorithm (AIPA) based on the simultaneous information provided by X-ray and radioisotopic images to determine the biokinetic models of Tc-99m radiopharmaceuticals from quantification of image radiation activity in murine models. These radioisotopic images were obtained by a CCD (charge couple device) camera coupled to an ultrathin phosphorous screen in a preclinical multimodal imaging system (Xtreme, Bruker). The AIPA consisted of different image processing methods for background, scattering and attenuation correction on the activity quantification. A set of parametric identification algorithms was used to obtain the biokinetic models that characterize the interaction between different tissues and the radiopharmaceuticals considered in the study. The set of biokinetic models corresponded to the Tc-99m biodistribution observed in different ex vivo studies. This fact confirmed the contribution of the semi-automatic image processing technique developed in this study.

  2. Development, implementation and quality assurance of biokinetic models within CONRAD

    International Nuclear Information System (INIS)

    Nosske, D.; Birchall, A.; Blanchardon, E.; Breustedt, B.; Giussani, A.; Luciani, A.; Oeh, U.; Lopez, M. A.

    2008-01-01

    The work of the Task Group 5.2 'Research Studies on Biokinetic Models' of the CONRAD project is presented. New biokinetic models have been implemented by several European institutions. Quality assurance procedures included intercomparison of the results as well as quality assurance of model formulation. Additionally, the use of the models was examined leading to proposals of tuning parameters. Stable isotope studies were evaluated with respect to their implications to the new models, and new biokinetic models were proposed on the basis of their results. Furthermore, the development of a biokinetic model describing the effects of decorporation of actinides by diethylenetriaminepentaacetic acid treatment was initiated. (authors)

  3. Evolution of the profession of biokinetics | Ellapen | South African ...

    African Journals Online (AJOL)

    The profession of Biokinetics has been undergoing significant evolution over the last decades. This paper provides an overview of the history of Biokinetics and the progressive changes to the professional bodies regulating the profession. These changes include the formulation of the Professional Board of Physiotherapy, ...

  4. Biokinetics of radionuclides and treatment of accidental intakes

    International Nuclear Information System (INIS)

    Taylor, D.M.; Stradling, G.N.; Menetrier, F.

    2003-01-01

    This paper describes the objectives and reviews the progress of EULEP Working Party 5, convened under the auspices of the European Union's Fifth Framework Programme, to 'cluster' two EU-supported contracts, Biokinetics and Dosimetry of Internal Contamination (BIODOS (EU Contract FIS5-1999-00214)) and Radionuclide Biokinetics Database (EULEP) ( RBDATA-EULEP (Concerted Action Contract FIS5-1999-00218), and two non-EU funded projects, Biokinetics of Radionuclides in Human Volunteers (RNHV (non-EU Funded Project) and Treatment of Accidental Intakes of Radionuclides (TAIR (part-funded by EULEP)). (author)

  5. Biokinetic model-based multi-objective optimization of Dunaliella tertiolecta cultivation using elitist non-dominated sorting genetic algorithm with inheritance.

    Science.gov (United States)

    Sinha, Snehal K; Kumar, Mithilesh; Guria, Chandan; Kumar, Anup; Banerjee, Chiranjib

    2017-10-01

    Algal model based multi-objective optimization using elitist non-dominated sorting genetic algorithm with inheritance was carried out for batch cultivation of Dunaliella tertiolecta using NPK-fertilizer. Optimization problems involving two- and three-objective functions were solved simultaneously. The objective functions are: maximization of algae-biomass and lipid productivity with minimization of cultivation time and cost. Time variant light intensity and temperature including NPK-fertilizer, NaCl and NaHCO 3 loadings are the important decision variables. Algal model involving Monod/Andrews adsorption kinetics and Droop model with internal nutrient cell quota was used for optimization studies. Sets of non-dominated (equally good) Pareto optimal solutions were obtained for the problems studied. It was observed that time variant optimal light intensity and temperature trajectories, including optimum NPK fertilizer, NaCl and NaHCO 3 concentration has significant influence to improve biomass and lipid productivity under minimum cultivation time and cost. Proposed optimization studies may be helpful to implement the control strategy in scale-up operation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Laboratory-scale in situ bioremediation in heterogeneous porous media: biokinetics-limited scenario.

    Science.gov (United States)

    Song, Xin; Hong, Eunyoung; Seagren, Eric A

    2014-03-01

    Subsurface heterogeneities influence interfacial mass-transfer processes and affect the application of in situ bioremediation by impacting the availability of substrates to the microorganisms. However, for difficult-to-degrade compounds, and/or cases with inhibitory biodegradation conditions, slow biokinetics may also limit the overall bioremediation rate, or be as limiting as mass-transfer processes. In this work, a quantitative framework based on a set of dimensionless coefficients was used to capture the effects of the competing interfacial and biokinetic processes and define the overall rate-limiting process. An integrated numerical modeling and experimental approach was used to evaluate application of the quantitative framework for a scenario in which slow-biokinetics limited the overall bioremediation rate of a polycyclic aromatic hydrocarbon (naphthalene). Numerical modeling was conducted to simulate the groundwater flow and naphthalene transport and verify the system parameters, which were used in the quantitative framework application. The experiments examined the movement and biodegradation of naphthalene in a saturated, heterogeneous intermediate-scale flow cell with two layers of contrasting hydraulic conductivities. These experiments were conducted in two phases: Phase I, simulating an inhibited slow biodegradation; and Phase II, simulating an engineered bioremediation, with system perturbations selected to enhance the slow biodegradation rate. In Phase II, two engineered perturbations to the system were selected to examine their ability to enhance in situ biodegradation. In the first perturbation, nitrogen and phosphorus in excess of the required stoichiometric amounts were spiked into the influent solution to mimic a common remedial action taken in the field. The results showed that this perturbation had a moderate positive impact, consistent with slow biokinetics being the overall rate-limiting process. However, the second perturbation, which was to

  7. Lead toxicokinetics. Development of a biokinetic model to understand and predict the outcome of treatment.

    Science.gov (United States)

    de Vries, I; Spaans, E; van Dijk, A; Meulenbelt, J

    1998-01-01

    Quite often physicians contact the Dutch Poisons Control Centre for information on patients with increased lead exposure. The most important questions raised by physicians dealing with these patients are how to estimate the lead exposure and the total lead body burden, how to interpret blood lead concentrations and whether the patient needs treatment. In order to answer these questions we need knowledge of the toxicokinetics of lead in the human body. To achieve insight and to make this knowledge accessible to physicians a biokinetic model for lead metabolism in the human body was developed. A four-compartment model with first-order kinetics, based on the concept of Kneip, was used. A biokinetic model uses a mathematical approach to translate the complex biological and kinetic behaviour of lead. In order to develop this biokinetic model two computer programmes were used. At the moment the model is tested with clinical data from patient treated at the medical toxicology outpatient clinic of the Utrecht University Hospital (this department cooperates very closely with the National Poisons Control Centre). Especially with regard to chelation therapy for elevated blood lead levels due to chronic exposure, the model is very helpful in visualising the toxicokinetics of lead in the human body. Toxicokinetic model might help improve knowledge of lead toxicokinetics, leading to well-considered guidelines for treatment of lead intoxications.

  8. Proposal of a new biokinetic model for niobium

    International Nuclear Information System (INIS)

    Oliveira, Roges

    2006-01-01

    There are two niobium isotopes generated in nuclear power plants: 95 Nb and 94 Nb. Workers and members of the public are subjects to intake these radionuclides in accident situation. For dose calculation purpose, it is very important to develop a model that describes in a more realistic way the kinetics of niobium inside of the human body. Presently the model adopted by ICRP (ICRP, 1989) is based on animal studies and describes the behavior of niobium in human being in a simple manner. The new model proposal describes the kinetics of the niobium from the intake into the blood until the excretion, doing this in a more realistic form and considering not only data from animals but data from human beings as well. For this objective, a workers group of a niobium extraction and processing industry exposed to stable niobium (93 Nb) in oxide insoluble form with associated uranium, was monitored for uranium and niobium determination in urinary and fecal excretion, by mass spectrometry. Based in the ratios of the niobium concentration in urinary and faecal excretion of this workers and animal data study, a new biokinetic model for niobium was proposed, with the followings modifications relative to ICRP model: a new compartment that represents muscular tissue; the fractions which are deposited into the compartment are modified; a third component in the retention equation of the bone tissue; introduction of recirculation between organs and blood. The new model was applied for a case of accidental intake and described adequately the experimental data

  9. Biokinetics and effects of barium sulfate nanoparticles.

    Science.gov (United States)

    Konduru, Nagarjun; Keller, Jana; Ma-Hock, Lan; Gröters, Sibylle; Landsiedel, Robert; Donaghey, Thomas C; Brain, Joseph D; Wohlleben, Wendel; Molina, Ramon M

    2014-10-21

    Nanoparticulate barium sulfate has potential novel applications and wide use in the polymer and paint industries. A short-term inhalation study on barium sulfate nanoparticles (BaSO₄ NPs) was previously published [Part Fibre Toxicol 11:16, 2014]. We performed comprehensive biokinetic studies of ¹³¹BaSO₄ NPs administered via different routes and of acute and subchronic pulmonary responses to instilled or inhaled BaSO₄ in rats. We compared the tissue distribution of ¹³¹Ba over 28 days after intratracheal (IT) instillation, and over 7 days after gavage and intravenous (IV) injection of ¹³¹BaSO₄. Rats were exposed to 50 mg/m³ BaSO₄ aerosol for 4 or 13 weeks (6 h/day, 5 consecutive days/week), and then gross and histopathologic, blood and bronchoalveolar lavage (BAL) fluid analyses were performed. BAL fluid from instilled rats was also analyzed. Inhaled BaSO₄ NPs showed no toxicity after 4-week exposure, but a slight neutrophil increase in BAL after 13-week exposure was observed. Lung burden of inhaled BaSO₄ NPs after 4-week exposure (0.84 ± 0.18 mg/lung) decreased by 95% over 34 days. Instilled BaSO₄ NPs caused dose-dependent inflammatory responses in the lungs. Instilled BaSO₄ NPs (0.28 mg/lung) was cleared with a half-life of ≈ 9.6 days. Translocated ¹³¹Ba from the lungs was predominantly found in the bone (29%). Only 0.15% of gavaged dose was detected in all organs at 7 days. IV-injected ¹³¹BaSO₄ NPs were predominantly localized in the liver, spleen, lungs and bone at 2 hours, but redistributed from the liver to bone over time. Fecal excretion was the dominant elimination pathway for all three routes of exposure. Pulmonary exposure to instilled BaSO₄ NPs caused dose-dependent lung injury and inflammation. Four-week and 13-week inhalation exposures to a high concentration (50 mg/m³) of BaSO₄ NPs elicited minimal pulmonary response and no systemic effects. Instilled and inhaled BaSO₄ NPs were cleared quickly yet

  10. Biokinetics – the development of a health profession from physical ...

    African Journals Online (AJOL)

    Biokinetics – the development of a health profession from physical education - a historical perspective. ... In this respect some medical aid funds supported this philosophy of health promotion, as the curative treatment of health problems are becoming increasingly expensive and are burdening health-care costs. At present ...

  11. The biokinetic of incorporates radionuclides; Die Biokinetik von inkorporierten Radionukliden

    Energy Technology Data Exchange (ETDEWEB)

    Breustedt, Bastian [Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany). Inst. fuer Strahlenforschung; Giussani, Augusto [Bundesamt fuer Strahlenschutz, Oberschleissheim (Germany). Arbeitsgruppe ' ' Externe und interne Dosimetrie, Biokinetik' '

    2017-08-01

    Incorporated radionuclides from nuclear accidents, fission product releases or nuclear medical administration are distributed in the human body in organs and tissue, absorbed 9or excreted. The interpretation of incorporation monitoring results and the estimation of the internal doses that cannot be measured directly need mathematical methods and the formulation of biokinetic models.

  12. 99mTc-UBI Biokinetics: A Specific Peptide for Infection Detection

    Science.gov (United States)

    Rodríguez-Cortés, J.; Meléndez-Alafort, L.; Herrera-Rodríguez, R.; Ferro-Flores, G.; Mitsoura, E.; Martínez-Duncker, C.

    2003-09-01

    Recently, antimicrobial peptides have been proposed as new agents to distinguish between bacterial infections and sterile inflammatory processes. Based on these considerations, Ubiquicidin peptide 29-41 (UBI) has been labeled with 99mTc using a new direct method showing a radiochemical purity > 97 %, high stability in human serum, and low protein binding. In addition 99mTc-UBI showed a specific in vitro and in vivo binding to bacteria. However its biokinetic parameters have not been evaluated since it is one of the new generation radiopharmaceuticals based on peptide structures. Therefore the aim of this project was to establish the biokinetic model for 99mTc-UBI. An activity from 74 to 148 MBq was injected to patients with bone infection and 5 whole body scans were taken at 1, 30, 120, 240 min and 24 h after radiopharmaceutical administration, with a dual head scanner. Urine was collected for 24 h. An antropomorphic phantom was previously used to calculate the effect of attenuation and scattered radiation on the gamma camera acquisition images. ROIs of the selected organs in patients (kidney, liver, heart, bone, soft tissue and lesion) were drawn, and attenuation and scatter corrected. The % urine elimination at 24 h and time integrated ROIs (cpm/pixel/ROIs) were used to obtain the residence time (τ) in each tissue and to establish the biokinetic model. Pharmacokinetic data show that blood clearance is biexponential with a mean residence time in the central compartment of 0.52 h. The images showed non-accumulation in metabolic organs. More than 75 % of the injected activity was eliminated by renal clearance 4 h after 99mTc-UBI administration. The mean radiation dose calculated according to the MIRD formalism was 0.130 mGy/MBq for kidney and the effective dose was 4.29 × 10-3 mSv/MBq.

  13. A biokinetic model of inhaled Cm compounds in dogs: Application to human exposure data

    International Nuclear Information System (INIS)

    Guilmette, R.A.; Mewhinney, J.A.

    1989-01-01

    Curium isotopes are major by-products in irradiated nuclear reactor fuel and comprise a significant fraction of the alpha-emitting radionuclide inventory. Although little use is currently being made of purified Cm sources, such usage is possible if reprocessing of spent fuel becomes feasible. Because little information is available on the biokinetics and dosimetry of inhaled Cm compounds, a study was conducted in which adult beagle dogs received a single inhalation exposure to either a monodisperse aerosol of 244Cm2O3 (1.4 micron activity median aerodynamic diameter [AMAD]; sigma g = 1.16) or a polydisperse aerosol of 244Cm (NO3)3 (1.1 micron AMAD; sigma g = 1.74). At times ranging from 4 h to 2 y after exposure, animals were sacrificed and their tissues analyzed for Cm content. The data describing the uptake and retention of 244Cm in the different organs and tissues and the measured rates of excretion of these dogs formed the basis on which a biokinetic model of Cm metabolism was constructed. This Cm model was based on a previously published model of the biokinetics of 241Am that was shown to be applicable to data from human cases of inhalation exposure to 241Am aerosols. This Cm model was found to be adequate to describe the biological distribution of Cm in dogs and was also applied to the sparse data from humans. Reasonable agreement was found between the model predictions for lung retention of Cm and for urinary excretion patterns in humans

  14. Different biokinetics of nanomedicines linking to their toxicity; an overview

    Directory of Open Access Journals (Sweden)

    Abdollahi Mohammad

    2013-02-01

    Full Text Available Abstract In spite of the extreme rise to the knowledge of nanotechnology in pharmaceutical sciences, there are currently limited experimental works studying the interactions between nanoparticles (NPs and the biological system. Adjustment of size and surface area plays the main role in the reaction between NPs and cells leading to their increased entrance into cells through skin, gastrointestinal and respiratory system. Moreover, change in physicochemical reactivity of NPs causes them to interact with circulatory and cellular proteins differentially leading to the altered parameters of their biokinetics, including adsorption, distribution, translocation, transformation, and elimination. A direct relationship between the surface area, reactive oxygen species generating capability, and proinflammatory effects of NPs have been found in respiratory tract toxicity. Additionally, complement-mediated hypersensitivity reactions to liposomes and other lipid-based nanodrugs have been well defined. Inhalation studies of some NPs have confirmed the translocation of inhaled materials to extra pulmonary organs such as central nervous system (CNS via olfactory neurons and induction of inflammatory response. Injectable uncoated NPs have a tendency to remain on the injection site while the poly ethanol glycol (PEG-coated NPs can be notably drained from the injection site to get as far as the lymph nodes where they accumulate. This confirms the existence of channels within the extracellular matrix for NPs to move along. Furthermore, induction of DNA strand breaks and formation of micronuclei have been recorded for exposure to some NPs such as single-walled carbon nanotubes. In the recent years, most of the studies have simply outlined better efficacy of nanodrugs, but few discussed their possible toxic reactions specially if used chronically. Therefore, we emphasize that this part of the nanoscience must not be undermined and toxicologists must be sensitive to

  15. Capstone depleted uranium aerosol biokinetics, concentrations, and doses.

    Science.gov (United States)

    Guilmette, Raymond A; Miller, Guthrie; Parkhurst, Mary Ann

    2009-03-01

    One of the principal goals of the Capstone Depleted Uranium (DU) Aerosol Study was to quantify and characterize DU aerosols generated inside armored vehicles by perforation with a DU penetrator. This study consequently produced a database in which the DU aerosol source terms were specified both physically and chemically for a variety of penetrator-impact geometries and conditions. These source terms were used to calculate radiation doses and uranium concentrations for various scenarios as part of the Capstone Human Health Risk Assessment (HHRA). This paper describes the scenario-related biokinetics of uranium, and summarizes intakes, chemical concentrations to the organs, and E(50) and HT(50) for organs and tissues based on exposure scenarios for personnel in vehicles at the time of perforation as well as for first responders. For a given exposure scenario (duration time and breathing rates), the range of DU intakes among the target vehicles and shots was not large, about a factor of 10, with the lowest being for a ventilated operational Abrams tank and the highest being for an unventilated Abrams with DU penetrator perforating DU armor. The ranges of committed effective doses were more scenario-dependent than were intakes. For example, the largest range, a factor of 20, was shown for scenario A, a 1 min exposure, whereas, the range was only a factor of two for the first-responder scenario (E). In general, the committed effective doses were found to be in the tens of mSv. The risks ascribed to these doses are discussed separately.

  16. Reliability of Current Biokinetic and Dosimetric Models for Radionuclides: A Pilot Study

    Energy Technology Data Exchange (ETDEWEB)

    Leggett, Richard Wayne [ORNL; Eckerman, Keith F [ORNL; Meck, Robert A. [U.S. Nuclear Regulatory Commission

    2008-10-01

    studied radionuclides. (4) The biokinetics of a radionuclide in the human body typically represents the greatest source of uncertainty or variability in dose per unit intake. (5) Characterization of uncertainty in dose per unit exposure is generally a more straightforward problem for external exposure than for intake of a radionuclide. (6) For many radionuclides the most important outcome of a large-scale critical evaluation of databases and biokinetic models for radionuclides is expected to be the improvement of current models. Many of the current models do not fully or accurately reflect available radiobiological or physiological information, either because the models are outdated or because they were based on selective or uncritical use of data or inadequate model structures. In such cases the models should be replaced with physiologically realistic models that incorporate a wider spectrum of information.

  17. Calibration of Biokinetic and Biological Parameters for a Groundwater Bioremediation Model using Heuristics and Function Approximation Optimization

    Science.gov (United States)

    Mugunthan, P.; Shoemaker, C. A.; Regis, R. G.

    2003-12-01

    Heuristics and function approximation optimization methods were applied in calibrating biological and biokinetic parameters for a computationally expensive groundwater bioremediation model for engineered reductive dechlorination of chlorinated ethenes. Multi-species groundwater bioremediation models that use monod type kinetics are often not amenable to traditional derivative based optimization due to stiff biokinetic equations. The performance of three heuristic methods, Stochastic Greedy Search (GS), Real Genetic Algorithm (RGA), Derandomized Evolution Strategy (DES), and, Function Approximation Optimization based on Radial Basis Function (FA-RBF) were compared on three-dimensional hypothetical and field problems. GS was implemented so as to perform a more global search. Optimization results on hypothetical problem indicated that FA-RBF performed statistically significantly better than heuristic based evolutionary algorithms at a 10% significance level. Further, this particular implementation of GS performed well and proved superior to RGA. These heuristic methods and FA-RBF, with the exception of RGA, were applied to calibrate biological and biokinetic parameters using treatability test data for enhanced bioremediation at a Naval Air Station in Alameda Point, CA. All three methods performed well and identified similar solutions. The approximate simulation times for the hypothetical and real problems were 7 min and 2.5 hours respectively. Calibration of such computationally expensive models by heuristic and function approximation methods appears promising.

  18. The biokinetics of uranium migrating from embedded DU fragments

    International Nuclear Information System (INIS)

    Leggett, R.W.; Pellmar, T.C.

    2003-01-01

    Military uses of depleted uranium (DU) munitions have resulted in casualties with embedded DU fragments. Assessment of radiological or chemical health risks from these fragments requires a model relating urinary U to the rate of migration of U from the fragments, and its accumulation in systemic tissues. A detailed biokinetic model for U has been published by the International Commission on Radiological Protection (ICRP), but its applicability to U migrating from embedded DU fragments is uncertain. Recently, ) conducted a study at the Armed Forces Radiobiology Research Institute (AFRRI) on the redistribution and toxicology of U in rats with implanted DU pellets, simulating embedded fragments. This paper compares the biokinetic data from that study with the behavior of commonly studied forms of U in rats (e.g., intravenously injected U nitrate). The comparisons indicate that the biokinetics of U migrating from embedded DU is similar to that of commonly studied forms of U with regard to long-term accumulation in kidneys, bone, and liver. The results provide limited support for the application of the ICRP's model to persons with embedded DU fragments. Additional information is needed with regard to the short-term behavior of migrating U and its accumulation in lymph nodes, brain, testicles, and other infrequently studied U repositories

  19. Age and gender specific biokinetic model for strontium in humans

    Energy Technology Data Exchange (ETDEWEB)

    Shagina, N. B.; Tolstykh, E. I.; Degteva, M. O.; Anspaugh, L. R.; Napier, Bruce A.

    2015-03-01

    A biokinetic model for strontium in humans is necessary for quantification of internal doses due to strontium radioisotopes. The ICRP-recommended biokinetic model for strontium has limitation for use in a population study, because it is not gender specific and does not cover all age ranges. The extensive Techa River data set on 90Sr in humans (tens of thousands of measurements) is a unique source of data on long-term strontium retention for men and women of all ages at intake. These, as well as published data, were used for evaluation of age- and gender-specific parameters for a new compartment biokinetic model for strontium (Sr-AGe model). The Sr-AGe model has similar structure as the ICRP model for the alkaline earth elements. The following parameters were mainly reevaluated: gastro-intestinal absorption and parameters related to the processes of bone formation and resorption defining calcium and strontium transfers in skeletal compartments. The Sr-AGe model satisfactorily describes available data sets on strontium retention for different kinds of intake (dietary and intravenous) at different ages (0–80 years old) and demonstrates good agreement with data sets for different ethnic groups. The Sr-AGe model can be used for dose assessment in epidemiological studies of general population exposed to ingested strontium radioisotopes.

  20. A physiological biokinetic model for the [7(N)-{sup 3}H]-cholesterol dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Adriano dos Santos; Martins, Joao Francisco Trencher; Velo, Alexandre Franca; Hamada, Margarida M.; Mesquita, Carlos Henrique de, E-mail: adriano_oliveira@usp.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2015-07-01

    Cardiovascular diseases (CVD) are a major source of deaths worldwide according to WHO (World Health Organization). It is well-known that the change of the level of plasma lipoproteins, which are responsible for the cholesterol transport in the bloodstream, is a main cause of these diseases. For this reason, to know the biokinetic parameters of plasma lipoproteins and quantifies them is important to correct and deepen the understanding of associated diseases. The main objective of this work is to provide a biokinetic model in order to estimate the radiometric dose, due to the intake of [7(N){sup -3}H] –Cholesterol in physiological issues, in metabolic studies. The internal dosimetry is important to know the biological effects of radiation. The model was based on Schwartz et al (2004), using parameters for the plasmatic lipoproteins and ICRP 30 (1979) gastrointestinal tract; the dose in the compartments were calculated using the MIRD methodology and the compartmental analysis by Matlab® software. The coefficients were estimated for an adult phantom with a body mass of 73.3 kg. (author)

  1. A physiological biokinetic model for the [7(N)-3H]-cholesterol dosimetry

    International Nuclear Information System (INIS)

    Oliveira, Adriano dos Santos; Martins, Joao Francisco Trencher; Velo, Alexandre Franca; Hamada, Margarida M.; Mesquita, Carlos Henrique de

    2015-01-01

    Cardiovascular diseases (CVD) are a major source of deaths worldwide according to WHO (World Health Organization). It is well-known that the change of the level of plasma lipoproteins, which are responsible for the cholesterol transport in the bloodstream, is a main cause of these diseases. For this reason, to know the biokinetic parameters of plasma lipoproteins and quantifies them is important to correct and deepen the understanding of associated diseases. The main objective of this work is to provide a biokinetic model in order to estimate the radiometric dose, due to the intake of [7(N) -3 H] –Cholesterol in physiological issues, in metabolic studies. The internal dosimetry is important to know the biological effects of radiation. The model was based on Schwartz et al (2004), using parameters for the plasmatic lipoproteins and ICRP 30 (1979) gastrointestinal tract; the dose in the compartments were calculated using the MIRD methodology and the compartmental analysis by Matlab® software. The coefficients were estimated for an adult phantom with a body mass of 73.3 kg. (author)

  2. Software for biokinetic modeling of the radiopharmaceuticals used in PET

    International Nuclear Information System (INIS)

    Cordeiro, Leanderson P.; Vieira, Igor F.; Lima, Fernando R.A. de; Vieira, Jose W.

    2013-01-01

    In this work will be presented the current state of software in development to estimate the dose from PET images. Will be given the main biokinetic models used in PET, as well as the general features of a tool in development, whose current features allow quantitative analysis of compartmental models. Further, the tool allows display images 2D PET (in DICOM format) and quantify the intensity map of regions of interest in counts per second coincidence events. The next step is to insert in the same tool to estimate the activity concentration for ROI and estimate dose from PET images static and / or dynamic

  3. Biokinetics and dosimetric studies about 99mTc(V)DMSA distribution

    International Nuclear Information System (INIS)

    Correia, M.B.L.; Magnata, S.S.L.P.; Silva, I.M.S.; Lima, F.F.; Catanho, M.T.J.A.

    2008-01-01

    Research for radiodiagnostic agents should considerate biological critical parameters as half-life effective, target/not target uptake ratio and metabolites that together will determinate the biokinetic. Each parameter give own contribution in the absorbed dose. The dimercaptosuccinic acid (DMSA) labeled with 99m Tc(VN) is a radiopharmaceutical which has well established role in medullar thyroid carcinoma and has been proposed in complementary evaluation of bone metastasis. The aim of this work was study the biokinetics and dosimetry of 99m Tc(V)-DMSA by animal model. The 99m Tc(V)-DMSA was prepared by (III)DMSA kit alkalized. The methodology used mice, 70 days old, both males and females. The animals (n=5) received 99m Tc(V)DMSA administered IV (tail vein). After determinate times (30 min, 1h, 5h and 12h) the animals were sacrificed, the organs (blood, lungs, kidneys, muscle and bone) were excised and the activities were measured by a gamma counter. The results were evaluated based on %activity/g and the absorbed dose was estimated by extrapolation of data from animal to human, using the residence time to each organ in the MIRDOSE 3.0 program. The results show that the majority of organs reaches the top uptake at 30 min, the kidney has the greatest uptake in this time, (4.81 ± 1.38) % activity per gram, while the bone presents its highest uptake at 1h (5.49 ± 0.47)% activity per gram, after 1h all the organs had activity exponential decrease. About the absorbed dose estimated to human scale, the preliminary results showed higher value to bone, being the soft tissue dose relatively low. These dose values, however, are submitted to biological implications which are under studying yet. The biokinetic profile of 99m Tc(V)-DMSA, prepared from a DMSA kit by IPEN, was well established, allowing quantifying of residence time, while the dosimetric model presented preliminary data which directs to new analyzes

  4. A biokinetic study of {sup 209}Po in man

    Energy Technology Data Exchange (ETDEWEB)

    Henricsson, C.F.; Ranebo, Y. [Department of Medical Radiation Physics, Clinical Sciences in Lund, Lund University, Skane University Hospital in Lund (Sweden); Hansson, M. [Medical Radiation Physics, Department of Clinical Sciences in Malmoe, Lund University, Skane University Hospital in Malmoe (Sweden); Raeaef, C.L., E-mail: Christopher.Raaf@med.lu.se [Medical Radiation Physics, Department of Clinical Sciences in Malmoe, Lund University, Skane University Hospital in Malmoe (Sweden); Holm, E. [Norwegian Radiation Protection Authority, Osteras (Norway)

    2012-10-15

    Five adult volunteers participated in a biokinetic study of radioactive polonium. Portions of about 10 Bq of {sup 209}Po were orally administrated to four of the volunteers in a single ingestion. The fifth volunteer ingested a daily amount of 53 mBq of 209Po for 243 d to study the time to achieve equilibrium between intake and excretion for protracted intakes. For the subjects ingesting single intakes of {sup 209}Po complete sampling of urine and feces was subsequently collected the first few days upon the ingestion. The samples were processed with radiochemical extraction and analyzed with alpha spectrometry. In the study, the maximum daily excretion rates in feces were 18-50% of the ingested activity, observed within 3 d after intake. Regarding the urine excretion, the daily excretion peaked, on average, at 0.15-1% of the ingested activity within two days upon intake. These results indicate an average gastro-intestinal uptake fraction of 0.46 {+-} 0.08, which agrees well with earlier biokinetic studies of polonium in man. -- Highlights: Black-Right-Pointing-Pointer Human metabolism of an oral intake of polonium. Black-Right-Pointing-Pointer 4 individuals were administrated about 10 Bq polonium-209. Black-Right-Pointing-Pointer Gastro-intestinal uptake fraction, if orally administrated polonium-209 was investigated. Black-Right-Pointing-Pointer The biological half-time of polonium in human body was studied.

  5. An optimization strategy for a biokinetic model of inhaled radionuclides

    International Nuclear Information System (INIS)

    Shyr, L.J.; Griffith, W.C.; Boecker, B.B.

    1991-01-01

    Models for material disposition and dosimetry involve predictions of the biokinetics of the material among compartments representing organs and tissues in the body. Because of a lack of human data for most toxicants, many of the basic data are derived by modeling the results obtained from studies using laboratory animals. Such a biomathematical model is usually developed by adjusting the model parameters to make the model predictions match the measured retention and excretion data visually. The fitting process can be very time-consuming for a complicated model, and visual model selections may be subjective and easily biased by the scale or the data used. Due to the development of computerized optimization methods, manual fitting could benefit from an automated process. However, for a complicated model, an automated process without an optimization strategy will not be efficient, and may not produce fruitful results. In this paper, procedures for, and implementation of, an optimization strategy for a complicated mathematical model is demonstrated by optimizing a biokinetic model for 144Ce in fused aluminosilicate particles inhaled by beagle dogs. The optimized results using SimuSolv were compared to manual fitting results obtained previously using the model simulation software GASP. Also, statistical criteria provided by SimuSolv, such as likelihood function values, were used to help or verify visual model selections

  6. Nuclear analytical techniques applied to the research on biokinetics of incorporated radionuclides for internal dosimetry

    International Nuclear Information System (INIS)

    Cantone, M.C.

    2005-01-01

    Full text: The presentation intends to discuss the contribution that techniques of analysis, based on activation analysis or mass spectrometry, can give to a very selected item of the protection against ionizing radiation: the biokinetics of relevant elements. The assessment of radiation dose to body tissues, following intakes of radionuclides in occupational, accidental exposures and environmental exposure in case of dispersion in the environment of radio contaminants of potential concerns, is essential to evaluate and manage the the related radiological risk, including the decisions and actions to be undertake. Internal dose is not directly measurable and the International Commission on Radiological Protection ICRP has developed models which describes the behavior of the substances in the human body, following their entry ways by inhalation or ingestion. Generally, all the available sources of information contribute in the modeling process, including studies on animals, use of chemical analogues and, obviously direct information on humans, which is definitely the preferred source on which a biokinetic model can be based. Biokinetic data on human are available for most of the biological essential elements (Fe, Zn, Cu, Se) and for some elements the metabolic behavior is well know due to their use in clinical application (I, Sr, Tc), moreover research is in progress for non-essential alpha emitters. However, for a number of element, including elements with radionuclide of radiological significance in case of environmental contamination (Ru, Zr, Ce, Te and Mo), human data are poor or missing and biokinetic parameters are essentially extrapolated from data on animals. The use of stable isotopes is a publicly well acceptable and ethically justifiable method, compared to the use of radioisotopes, when volunteer subjects are considered in the investigations. The design of the investigation is based on the double tracer approach: one isotope is given orally and a second

  7. Biokinetic study for SRC-I wastewater

    Energy Technology Data Exchange (ETDEWEB)

    1984-06-01

    Biooxidation is an important part of the overall wastewater treatment system for the proposed SRC-I Demonstration Plant in Newman, Kentucky. After the completion of a Baseline Design for the plant in April 1982, various refinements were evaluated. One of these was the inclusion of a process for phenol recovery from four sour-water streams. As part of this evaluation, an extensive laboratory treatability study was conducted on wastewaters both with and without this phenol recovery step. The purpose of the study was to compare the results of different treatment schemes on different wastewaters and did not include the development of the kinetic coefficients that govern the biooxidation process. Additional treatability testing documented herein, has been performed to establish the kinetic coefficients for biooxidation of the SRC-I wastewaters. This will provide a rational basis for any subsequent changes in design. The wastewater feed used in this study was process recycle water from the Fort Lewis, Washington, pilot plant. Prior to biooxidation, it was pretreated by solvent extraction for removal of phenolics and by steam stripping for removal of ammonia and hydrogen sulfide. Two, 2-stage bench scale bioreactors were operated for approximately eight months, during which time they were stabilized at various steady-state conditions. Kinetic coefficients were evaluated according to the Lawrence and McCarty model, based on BOD, COD, and TOC. Nitrification, oxygen utilization, and solids settling velocities were also studied. The results showed that BOD is a poor basis for the model mainly because almost all BOD/sub 5/ was removed at all steady-state conditions. Also, the model was more accurate for steady-state conditions of lower solids retention times. The bulk of both organic and ammonia reductions occurred in the first stage reactors.

  8. Compared biokinetic and biological studies of chronic and acute inhalations of uranium compounds in the rat

    International Nuclear Information System (INIS)

    Monleau, M.

    2005-12-01

    Uranium is a natural, radioactive heavy metal, widely used in the nuclear industry in various chemical and isotopic forms. Its use in the fuel cycle involves the risk of radiological exposure for the workers, mainly via the inhalation of uranium particles. According to the workplace configuration, uranium contaminations can be acute or repeated, involve various chemical forms and different levels of enrichment, as well as involving one or several components. The dosimetric concepts and models available for workers' radiological protection, as well as most of the studies of the biological effects, correspond to acute exposure situations. Moreover the processes leading to pathological effects are little known in vivo. In this context, the main question is to know whether exposures due to repeated inhalation by rats induce the element kinetics and toxicity, which may be different from those observed after an acute exposure. In this study, comparison of the experimental and theoretical biokinetics of an insoluble uranium repeatedly inhaled over three weeks shows that a chronic contamination is correctly modelled, except for bone retention, by the sum of acute, successive and independent incorporations. Moreover, the kinetics of a soluble uranium inhaled irregularly can be modified by previous repeated exposure to an insoluble uranium. In certain cases therefore, exposure to uranium could modify its biokinetics during later exposures. At a toxicological level, the study demonstrates that the uranium particles inhaled repeatedly induce behavioural disruptions and genotoxic effects resulting in various sorts of DNA damage, in several cell types and certainly depending on the quantity inhaled. Exposures involving several uraniferous components produce a synergy effect. Moreover, repeated inhalations worsen the genotoxic effects in comparison to an acute exposure. This work demonstrates the importance of not ignoring the effects of the repetition of uranium exposure. It

  9. Study of the influence of radionuclide biokinetics on in vivo counting using voxel phantoms

    International Nuclear Information System (INIS)

    Lamart, St.

    2008-10-01

    The in vivo measurement is an efficient method to estimate the retention of activity in case of internal contamination. However, it is currently limited by the use of physical phantoms for the calibration, not enabling to reproduce neither the morphology of the measured person nor the actual distribution of the contamination. The current method of calibration therefore leads to significant systematic uncertainties on the quantification of the contamination. To improve the in vivo measurement, the Laboratory of Internal Dose Assessment (LEDI, IRSN) has developed an original numerical calibration method with the OEDIPE software. It is based on voxel phantoms created from the medical images of persons, and associated with the MCNPX Monte Carlo code of particle transport. The first version of this software enabled to model simple homogeneous sources and to better estimate the systematic uncertainties in the lung counting of actinides due to the detector position and to the heterogeneous distribution of activity inside the lungs. However, it was not possible to take into account the dynamic feature, and often heterogeneous distribution between body organs and tissues of the activity. Still, the efficiency of the detection system depends on the distribution of the source of activity. The main purpose of the thesis work is to answer to the question: what is the influence of the biokinetics of the radionuclides on the in vivo counting? To answer it, it was necessary to deeply modify OEDIPE. This new development enabled to model the source of activity more realistically from the reference biokinetic models defined by the ICRP. The first part of the work consisted in developing the numerical tools needed to integrate the biokinetics in OEDIPE. Then, a methodology was developed to quantify its influence on the in vivo counting from the results of simulations. This method was carried out and validated on the model of the in vivo counting system of the LEDI. Finally, the

  10. Performance analysis of numeric solutions applied to biokinetics of radionuclides

    International Nuclear Information System (INIS)

    Mingatos, Danielle dos Santos; Bevilacqua, Joyce da Silva

    2013-01-01

    Biokinetics models for radionuclides applied to dosimetry problems are constantly reviewed by ICRP. The radionuclide trajectory could be represented by compartmental models, assuming constant transfer rates between compartments. A better understanding of physiological or biochemical phenomena, improve the comprehension of radionuclide behavior in the human body and, in general, more complex compartmental models are proposed, increasing the difficulty of obtaining the analytical solution for the system of first order differential equations. Even with constant transfer rates numerical solutions must be carefully implemented because of almost singular characteristic of the matrix of coefficients. In this work we compare numerical methods with different strategies for ICRP-78 models for Thorium-228 and Uranium-234. The impact of uncertainty in the parameters of the equations is also estimated for local and global truncation errors. (author)

  11. A biokinetic and dosimetric model for the metabolism of uranium

    International Nuclear Information System (INIS)

    Wrenn, M.E.; Bertelli, L.; Durbin, P.W.; Eckerman, K.F.; Lipsztein, J.L.; Singh, N.P.

    1995-10-01

    Experiments involving injection and inhalation of uranium compounds into several animal species as well as those associated with humans are described and analyzed. A revised biokinetic and dosimetric model for the metabolism of uranium suitable for bioassay procedures is proposed. The model consists of a systematic part coupled to a model of the respiratory tract. The model has been tested against human data which incorporates in vivo measurements over the chest and measurements of urine, feces, and autopsy and biopsy samples.In particular the lung model of the International Commission on Radiological Protection, Publication 30 ( ICRP-30 ), has been modified in order to provide a model which more nearly predicts urinary excretion in accord with the experiences in humans and animals. We have also tested the data against the new ICRP (LUDEP) lung model. (author). 55 refs., 14 tabs., 33 figs

  12. A generic biokinetic model for predicting the behaviour of the lanthanide elements in the human body

    International Nuclear Information System (INIS)

    Taylor, D.M.; Leggett, R.W.

    2003-01-01

    Information on the biokinetics of the 15 elements of the lanthanide series, 57 La to 71 Lu, is too sparse to permit individual development of meaningful biokinetic models to describe the behaviour of each of the elements in humans. The lanthanides show a regular gradation in chemical properties across the series, and animal studies indicate that this is reflected in regular differences in their deposition in tissues such as the liver and skeleton. These regular differences in chemical and biological behaviour have been utilised to construct a generic lanthanide biokinetic model and to define element-specific parameters for each element in the series. This report describes the use of the available biokinetic data for humans and animals to derive the parameters for each of the elements. (author)

  13. A case of accidental intake of Molybdenum Radionuclides: analysis of data with a revised biokinetic model

    International Nuclear Information System (INIS)

    Giussani, A.; Cantone, M.C.; Tavola, F.; Lopez, M.A.; Navarro, T.

    2002-01-01

    In recent years, a series of investigations on the biokinetics of molybdenum in humans, conducted using stable isotopes of Mo as tracers, has provided valuable experimental data about the dynamics of relevant processes such as the uptake from the gut walls, the clearance from the systemic circulation and the elimination pathways. The results of these studies are in good agreement with the findings of a group of nutritionist who also performed biokinetic studies with stable tracers. All measurements show several deviations from the predictions of the current ICRP model. On the basis of these data, a preliminary revision of the biokinetic model for Mo was presented. The modified model was thus used as a starting point for a new series of biokinetic investigations, aimed at a better definition of some of its features. In a total of 54 studies conducted in 15 volunteers, the influence of the mass and of the chemical form on intestinal absorption, internal kinetics and urinary excretion was investigated

  14. A generic biokinetic model for predicting the behaviour of the lanthanide elements in the human body

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, D.M.; Leggett, R.W

    2003-07-01

    Information on the biokinetics of the 15 elements of the lanthanide series, {sup 57}La to {sup 71}Lu, is too sparse to permit individual development of meaningful biokinetic models to describe the behaviour of each of the elements in humans. The lanthanides show a regular gradation in chemical properties across the series, and animal studies indicate that this is reflected in regular differences in their deposition in tissues such as the liver and skeleton. These regular differences in chemical and biological behaviour have been utilised to construct a generic lanthanide biokinetic model and to define element-specific parameters for each element in the series. This report describes the use of the available biokinetic data for humans and animals to derive the parameters for each of the elements. (author)

  15. Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction

    Directory of Open Access Journals (Sweden)

    Choi SJ

    2014-12-01

    Full Text Available Soo-Jin Choi,1 Jin-Ho Choy2 1Department of Food Science and Technology, Seoul Women's University, 2Center for Intelligent Nano Bio Materials (CINBM, Department of Bioinspired Science and Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, South Korea Abstract: Biokinetic studies of zinc oxide (ZnO nanoparticles involve systematic and quantitative analyses of absorption, distribution, metabolism, and excretion in plasma and tissues of whole animals after exposure. A full understanding of the biokinetics provides basic information about nanoparticle entry into systemic circulation, target organs of accumulation and toxicity, and elimination time, which is important for predicting the long-term toxic potential of nanoparticles. Biokinetic behaviors can be dependent on physicochemical properties, dissolution property in biological fluids, and nanoparticle–protein interaction. Moreover, the determination of biological fates of ZnO nanoparticles in the systemic circulation and tissues is critical in interpreting biokinetic behaviors and predicting toxicity potential as well as mechanism. This review focuses on physicochemical factors affecting the biokinetics of ZnO nanoparticles, in concert with understanding bioavailable fates and their interaction with proteins. Keywords: ZnO nanoparticles, biokinetics, distribution, excretion, fate, interaction

  16. Strontium biokinetic model for the lactating woman and transfer to breast milk: application to Techa River studies

    International Nuclear Information System (INIS)

    Shagina, N B; Tolstykh, E I; Degteva, M O; Fell, T P; Smith, T J; Harrison, J D

    2015-01-01

    This paper presents a biokinetic model for strontium metabolism in the lactating woman and transfer to breast milk for members of Techa River communities exposed as a result of discharges of liquid radioactive wastes from the Mayak plutonium production facility (Russia) in the early 1950s. This model was based on that developed for the International Commission for Radiological Protection with modifications to account for population specific features of breastfeeding and maternal bone mineral metabolism. The model is based on a biokinetic model for the adult female with allowances made for changes in mineral metabolism during periods of exclusive and partial breast-feeding. The model for females of all ages was developed earlier from extensive data on 90 Sr-body measurements for Techa Riverside residents. Measurements of 90 Sr concentrations in the maternal skeleton and breast milk obtained in the1960s during monitoring of global fallout in the Southern Urals region were used for evaluation of strontium transfer to breast and breast milk. The model was validated with independent data from studies of global fallout in Canada and measurements of 90 Sr body-burden in women living in the Techa River villages who were breastfeeding during maximum 90 Sr-dietary intakes. The model will be used in evaluations of the intake of strontium radioisotopes in breast milk by children born in Techa River villages during the radioactive releases and quantification of 90 Sr retention in the maternal skeleton. (paper)

  17. The biokinetics of Rhuthenium and Zirconium radionuclides in humans studied with stable tracers

    International Nuclear Information System (INIS)

    Veronese, I.; Cantone, M.C.; Giussani, A.

    2002-01-01

    The assessment of the internal radiation dose delivered by radionuclides incorporated in the human body after accidental release into the environment requires the use of suitable biokinetic models. These models describe the absorption of radionuclides into the blood circulation, their distribution and retention in various organs and tissues, and the excretion routes. Biokinetic models are also employed for interpreting bioassay measurements in exposed subjects, like activity concentration measurements in body fluids (e.g. urine, blood), in order to estimate the incorporated amount of radioactive substances. The reliability of a biokinetic model is closely linked to the available experimental data used to develop the model itself. Biokinetic data for human subjects are available for most essential elements, as well as for some important non-essential elements such as caesium, lead, radium, uranium, americium and plutonium. For many other radionuclides, either very little or no information is available from human studies, and the respective models must be derived from other sources. These may include results from studies in animals, comparative data on the behaviour of similar radionuclides or chemical analogues in vitro. Biokinetic models developed from such a variety of data sources can be applied to humans only with a limited degree of confidence. The availability of data directly obtained on human subjects is therefore fundamental to set up more reliable and realistic models. Ruthenium and zirconium are among the elements characterised by a serious lack of reliable data in humans

  18. Parameter uncertainty analysis of a biokinetic model of caesium

    International Nuclear Information System (INIS)

    Li, W.B.; Oeh, U.; Klein, W.; Blanchardon, E.; Puncher, M.; Leggett, R.W.; Breustedt, B.; Nosske, D.; Lopez, M.A.

    2015-01-01

    Parameter uncertainties for the biokinetic model of caesium (Cs) developed by Leggett et al. were inventoried and evaluated. The methods of parameter uncertainty analysis were used to assess the uncertainties of model predictions with the assumptions of model parameter uncertainties and distributions. Furthermore, the importance of individual model parameters was assessed by means of sensitivity analysis. The calculated uncertainties of model predictions were compared with human data of Cs measured in blood and in the whole body. It was found that propagating the derived uncertainties in model parameter values reproduced the range of bioassay data observed in human subjects at different times after intake. The maximum ranges, expressed as uncertainty factors (UFs) (defined as a square root of ratio between 97.5. and 2.5. percentiles) of blood clearance, whole-body retention and urinary excretion of Cs predicted at earlier time after intake were, respectively: 1.5, 1.0 and 2.5 at the first day; 1.8, 1.1 and 2.4 at Day 10 and 1.8, 2.0 and 1.8 at Day 100; for the late times (1000 d) after intake, the UFs were increased to 43, 24 and 31, respectively. The model parameters of transfer rates between kidneys and blood, muscle and blood and the rate of transfer from kidneys to urinary bladder content are most influential to the blood clearance and to the whole-body retention of Cs. For the urinary excretion, the parameters of transfer rates from urinary bladder content to urine and from kidneys to urinary bladder content impact mostly. The implication and effect on the estimated equivalent and effective doses of the larger uncertainty of 43 in whole-body retention in the later time, say, after Day 500 will be explored in a successive work in the framework of EURADOS. (authors)

  19. Bioavailability and Biokinetics of Anthocyanins From Red Grape Juice and Red Wine

    Directory of Open Access Journals (Sweden)

    Roland Bitsch

    2004-01-01

    Full Text Available In a comparative study, 9 healthy volunteers ingested a single oral dose of 400 mL red grape juice or red wine with dose-adjusted anthocyanin content (283.5 mg or 279.6 mg, resp. in crossover. The content of anthocyanin glucosides was detected in plasma and urinary excretion. Additionally, the plasmatic antioxidant activity was assessed after intake. Based on the plasma content, biokinetic criteria of the single anthocyanins were calculated, such as AUC, cmax, tmax, and the elimination rate t1/2. The urinary excretion of total anthocyanins differed significantly and amounted to 0.18% (red wine and 0.23% (red grape juice of the administered dose. Additionally, the plasmatic antioxidant activity increased to higher levels after juice ingestion compared to wine. The intestinal absorption of the anthocyanins of red grape juice seemed to be improved compared to red wine, suggesting a possible synergistic effect of the glucose content of the juice. The improved absorption resulted in an enhanced plasmatic bioactivity.

  20. A novel bench-scale column assay to investigate site-specific nitrification biokinetics in biological rapid sand filters

    DEFF Research Database (Denmark)

    Tatari, Karolina; Smets, Barth F.; Albrechtsen, Hans-Jørgen

    2013-01-01

    A bench-scale assay was developed to obtain site-specific nitrification biokinetic information from biological rapid sand filters employed in groundwater treatment. The experimental set-up uses granular material subsampled from a full-scale filter, packed in a column, and operated with controlled...... and continuous hydraulic and ammonium loading. Flowrates and flow recirculation around the column are chosen to mimic full-scale hydrodynamic conditions, and minimize axial gradients. A reference ammonium loading rate is calculated based on the average loading experienced in the active zone of the full......-scale filter. Effluent concentrations of ammonium are analyzed when the bench-scale column is subject to reference loading, from which removal rates are calculated. Subsequently, removal rates above the reference loading are measured by imposing short-term loading variations. A critical loading rate...

  1. Radiation fields, dosimetry, biokinetics and biophysical models for cancer induction by ionising radiation 1996-1999. Biokinetics and dosimetry of incorporated radionuclides. Final report

    International Nuclear Information System (INIS)

    Roth, P.; Aubineau-Laniece, I.; Bailly-Despiney, I.

    2000-01-01

    The final report 'Biokinetics and Dosimetry of Incorporated Radionuclides' presented here is one part of the 5 individual reports. The work to be carried out within this project is structured into four Work Packages: Workpackage 1 concentrates on ingested radionuclides, considering doses to the GI tract and radionuclide absorption. A major objective is the development of a new dosimetric model of the GI tract, taking account of most recent data on gut transit and dose to sensitive cells. Workpackage 2 seeks to improve and extend biokinetic and dosimetric models for systemic radionuclides. Existing models for adults and children will be extended to other elements and new models will be developed for the embryo and fetus. Workpackage 3 is to improve assessment of localised distribution of dose within tissues at the cellular level for specific examples of Auger emitters and alpha emitting isotopes, in relation to observed effects. The work will include experimental studies of dose/effect relationship and the development of localisation methods. Workpackage 4 concerns the development of computer codes for the new dosimetric models, quality assurance of the models and the calculation of dose coefficients. Formal sensitivity analysis will be used to identify critical areas of model development and to investigate the effects of variability and incertainty in biokinetic parameters. (orig.)

  2. A profile of Biokinetics service provided by the University of Kwa ...

    African Journals Online (AJOL)

    Biokinetics can be viewed as an emerging member of the South African health professions in comparison to the longstanding professions of physiotherapy, chiropractics and occupational therapy which were established in 1924, 1939 and 1945, respectively. The aim of this investigation was to determine the profile of the ...

  3. Distribution and biokinetic analysis of {sup 210}Pb and {sup 210}Po in poultry due to ingestion of dicalcium phosphate

    Energy Technology Data Exchange (ETDEWEB)

    Casacuberta, N., E-mail: Nuria.Casacuberta@uab.es [Departament de Fisica and Institut de Ciencia i Tecnologia Ambientals, Universitat Autonoma de Barcelona, 08193 Bellaterra (Spain); Traversa, F.L. [Departament d' Electronica, Escola Tecnica Superior d' Enginyeria, Universitat Autonoma de Barcelona, 08193 Bellaterra (Spain); Masque, P.; Garcia-Orellana, J. [Departament de Fisica and Institut de Ciencia i Tecnologia Ambientals, Universitat Autonoma de Barcelona, 08193 Bellaterra (Spain); Anguita, M.; Gasa, J. [Departament de Ciencia Animal i dels Aliments, Universitat Autonoma de Barcelona, 08193 Bellaterra (Spain); Garcia-Tenorio, R. [Universidad de Sevilla, Avda. Reina Mercedes s/n, 41012 Sevilla (Spain)

    2010-09-15

    Dicalcium phosphate (DCP) is used as a calcium supplement for food producing animals (i.e., cattle, poultry and pig). When DCP is produced via wet acid digestion of the phosphate rock and depending on the acid used in the industrial process, the final product can result in enhanced {sup 210}Pb and {sup 210}Po specific activities ({approx} 2000 Bq.kg{sup -1}). Both {sup 210}Pb and {sup 210}Po are of great interest because their contribution to the dose received by ingestion is potentially large. The aims of this work are to examine the accumulation of {sup 210}Pb and {sup 210}Po in chicken tissues during the first 42 days of life and to build a suitable single-compartment biokinetic model to understand the behavior of both radionuclides within the entire animal using the experimental results. Three commercial corn-soybean-based diets containing different amounts and sources of DCP were fed to broilers during a period of 42 days. The results show that diets containing enhanced concentrations of {sup 210}Pb and {sup 210}Po lead to larger specific accumulation in broiler tissues compared to the blank diet. Radionuclides do not accumulate homogeneously within the animal body: {sup 210}Pb follows the calcium pathways to some extent and accumulates largely in bones, while {sup 210}Po accumulates to a large extent in liver and kidneys. However, the total amount of radionuclide accumulation in tissues is small compared to the amounts excreted in feces. The single-compartment non-linear biokinetic model proposed here for {sup 210}Pb and {sup 210}Po in the whole animal takes into account the size evolution and is self-consistent in that no fitting parameterization of intake and excretions rates is required.

  4. Quantitative biokinetics of titanium dioxide nanoparticles after intravenous injection in rats: Part 1.

    Science.gov (United States)

    Kreyling, Wolfgang G; Holzwarth, Uwe; Haberl, Nadine; Kozempel, Ján; Hirn, Stephanie; Wenk, Alexander; Schleh, Carsten; Schäffler, Martin; Lipka, Jens; Semmler-Behnke, Manuela; Gibson, Neil

    2017-05-01

    Submicrometer TiO 2 particles, including nanoparticulate fractions, are used in an increasing variety of consumer products, as food additives and also drug delivery applications are envisaged. Beyond exposure of occupational groups, this entails an exposure risk to the public. However, nanoparticle translocation from the organ of intake and potential accumulation in secondary organs are poorly understood and in many investigations excessive doses are applied. The present study investigates the biokinetics and clearance of a low single dose (typically 40-400 μg/kg BW) of 48 V-radiolabeled, pure TiO 2 anatase nanoparticles ([ 48 V]TiO 2 NP) with a median aggregate/agglomerate size of 70 nm in aqueous suspension after intravenous (IV) injection into female Wistar rats. Biokinetics and clearance were followed from one-hour to 4-weeks. The use of radiolabeled nanoparticles allowed a quantitative [ 48 V]TiO 2 NP balancing of all organs, tissues, carcass and excretions of each rat without having to account for chemical background levels possibly caused by dietary or environmental titanium exposure. Highest [ 48 V]TiO 2 NP accumulations were found in liver (95.5%ID after one day), followed by spleen (2.5%), carcass (1%), skeleton (0.7%) and blood (0.4%). Detectable nanoparticle levels were found in all other organs. The [ 48 V]TiO 2 NP content in blood decreased rapidly after 24 h while the distribution in other organs and tissues remained rather constant until day-28. The present biokinetics study is part 1 of a series of studies comparing biokinetics after three classical routes of intake (IV injection (part 1), ingestion (part 2), intratracheal instillation (part 3)) under identical laboratory conditions, in order to test the common hypothesis that IV-injection is a suitable predictor for the biokinetics fate of nanoparticles administered by different routes. This hypothesis is disproved by this series of studies.

  5. Controlling intake of uranium in the workplace: Applications of biokinetic modeling and occupational monitoring data

    Energy Technology Data Exchange (ETDEWEB)

    Leggett, Richard Wayne [ORNL; Eckerman, Keith F [ORNL; McGinn, Wilson [ORNL; Meck, Dr. Robert A. [U.S. Nuclear Regulatory Commission

    2012-01-01

    This report provides methods for interpreting and applying occupational uranium monitoring data. The methods are based on current international radiation protection guidance, current information on the chemical toxicity of uranium, and best available biokinetic models for uranium. Emphasis is on air monitoring data and three types of bioassay data: the concentration of uranium in urine; the concentration of uranium in feces; and the externally measured content of uranium in the chest. Primary Reference guidance levels for prevention of chemical effects and limitation of radiation effects are selected based on a review of current scientific data and regulatory principles for setting standards. Generic investigation levels and immediate action levels are then defined in terms of these primary guidance levels. The generic investigation and immediate actions levels are stated in terms of radiation dose and concentration of uranium in the kidneys. These are not directly measurable quantities, but models can be used to relate the generic levels to the concentration of uranium in air, urine, or feces, or the total uranium activity in the chest. Default investigation and immediate action levels for uranium in air, urine, feces, and chest are recommended for situations in which there is little information on the form of uranium taken into the body. Methods are prescribed also for deriving case-specific investigation and immediate action levels for uranium in air, urine, feces, and chest when there is sufficient information on the form of uranium to narrow the range of predictions of accumulation of uranium in the main target organs for uranium: kidneys for chemical effects and lungs for radiological effects. In addition, methods for using the information herein for alternative guidance levels, different from the ones selected for this report, are described.

  6. Development of a New Bio-Kinetic Model for Assessing the Environmental Property of Military Hydraulic Fluids

    National Research Council Canada - National Science Library

    Rhee, In-Sik

    2006-01-01

    ... (POL) products utilized in the current and future combat systems. As part of these efforts, a bio-kinetic model was developed to predict the biodegradability of lubricants including hydraulic fluids...

  7. Quantitative biokinetics of titanium dioxide nanoparticles after oral application in rats: Part 2.

    Science.gov (United States)

    Kreyling, Wolfgang G; Holzwarth, Uwe; Schleh, Carsten; Kozempel, Ján; Wenk, Alexander; Haberl, Nadine; Hirn, Stephanie; Schäffler, Martin; Lipka, Jens; Semmler-Behnke, Manuela; Gibson, Neil

    2017-05-01

    The biokinetics of a size-selected fraction (70 nm median size) of commercially available and 48 V-radiolabeled [ 48 V]TiO 2 nanoparticles has been investigated in female Wistar-Kyoto rats at retention timepoints 1 h, 4 h, 24 h and 7 days after oral application of a single dose of an aqueous [ 48 V]TiO 2 -nanoparticle suspension by intra-esophageal instillation. A completely balanced quantitative body clearance and biokinetics in all organs and tissues was obtained by applying typical [ 48 V]TiO 2 -nanoparticle doses in the range of 30-80 μg•kg -1 bodyweight, making use of the high sensitivity of the radiotracer technique. The [ 48 V]TiO 2 -nanoparticle content was corrected for nanoparticles in the residual blood retained in organs and tissue after exsanguination and for 48 V-ions not bound to TiO 2 -nanoparticles. Beyond predominant fecal excretion about 0.6% of the administered dose passed the gastro-intestinal-barrier after one hour and about 0.05% were still distributed in the body after 7 days, with quantifiable [ 48 V]TiO 2 -nanoparticle organ concentrations present in liver (0.09 ng•g -1 ), lungs (0.10 ng•g -1 ), kidneys (0.29 ng•g -1 ), brain (0.36 ng•g -1 ), spleen (0.45 ng•g -1 ), uterus (0.55 ng•g -1 ) and skeleton (0.98 ng•g -1 ). Since chronic, oral uptake of TiO 2 particles (including a nano-fraction) by consumers has continuously increased in the past decades, the possibility of chronic accumulation of such biopersistent nanoparticles in secondary organs and the skeleton raises questions about the responsiveness of their defense capacities, and whether these could be leading to adverse health effects in the population at large. After normalizing the fractions of retained [ 48 V]TiO 2 -nanoparticles to the fraction that passed the gastro-intestinal-barrier and reached systemic circulation, the biokinetics was compared to the biokinetics determined after IV-injection (Part 1). Since the biokinetics patterns

  8. ICRP 67 Biokinetic Models for AM-241 Applied to Nonhuman Primates.

    Science.gov (United States)

    Alomairy, Nada A; Brey, Richard R; Guilmette, Raymond A

    2017-05-01

    Between 1960 and 1985, Patricia Durbin and colleagues performed studies on the distribution of intravenously and intramuscularly injected Am citrate with dosages ranging from 16 to 32 kBq kg in 30 male and female non-human primates (NHP). Dr. Durbin died unexpectedly in March of 2009, leaving much of the extensive serial blood, bioassay, and autopsy data from these NHP studies unanalyzed. As part of the experimental design, serial blood samples were taken, and urine and feces samples were collected separately for the duration of the study. The measurements of urine, fecal excretion, blood samples, and organ burden data obtained from the animals were used to evaluate the transfer rates of the ICRP 67 biokinetic model for Am. Seven cases, in which the primates were administered Am citrate by intravenous injection, were evaluated using the ICRP 67 systemic model. There were differences ranging from 51.4% underestimated to 102.7% overestimated activity between the predicted intake, which was calculated using IMBA Professional Plus software and based upon the urine bioassay data and the actual activity. The difference between the predicted activity at the time of death in the liver and skeleton using IMBA professional software and the value of the measured activity at the time of death were also compared. Generally, the ratios of predicted activity in the liver and skeleton at the time of death to the measured activity were consistently more than 1. However, the ratios were less than 1 in the skeleton for animals that were sacrificed 2,199 and 973 d post injection. The posterior probability distributions for model parameters derived using WeLMoS method were inconsistent with the ICRP 67 default parameters. The prediction made based on the posterior probability distributions for model parameters derived using WeLMoS gave the best fit to these data; however, the modified parameters overestimated the activity in almost all cases. The difference between the predicted Am

  9. Implementation of iodine biokinetic model for interpreting I-131 contamination in breast milk after the Fukushima nuclear disaster

    Science.gov (United States)

    Tani, Kotaro; Kurihara, Osamu; Kim, Eunjoo; Yoshida, Satoshi; Sakai, Kazuo; Akashi, Makoto

    2015-07-01

    After the accident at the Fukushima Daiichi Nuclear Power Plant run by Tokyo Electric Power Company in 2011, breast milk samples obtained from volunteers living in Fukushima and neighboring prefectures were examined and small amounts of I-131 (2.2-36.3 Bq/kg) were detected in some samples. In this work, the I-131 concentrations in breast milk from nursing mothers in Ibaraki prefecture were calculated based on the iodine biokinetic model during lactation together with time-variable intake scenarios by inhalation of ambient air and ingestion of tap water, using the authors’ code. The calculated I-131 concentrations in breast milk generally agreed with those measured for the volunteers. Based on the results, thyroid equivalent doses to breast-fed infants were estimated for each place of residence of the volunteers on the assumption that these infants consumed 800 ml of breast milk every day, resulting in 10-11 mSv for Mito and Kasama cities and 1.1-1.8 mSv for Tsukuba and Moriya cities. It was suggested that breast milk consumption could be a major contributor to internal dose of breast-fed infants in areas with mild I-131 pollution; however, further studies considering personal behavior surveys would be necessary to estimate individual doses.

  10. Proposal of a new biokinetic model for niobium; Proposta de um novo modelo biocinetico para o niobio

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Roges

    2006-07-01

    There are two niobium isotopes generated in nuclear power plants: 95 Nb and 94 Nb. Workers and members of the public are subjects to intake these radionuclides in accident situation. For dose calculation purpose, it is very important to develop a model that describes in a more realistic way the kinetics of niobium inside of the human body. Presently the model adopted by ICRP (ICRP, 1989) is based on animal studies and describes the behavior of niobium in human being in a simple manner. The new model proposal describes the kinetics of the niobium from the intake into the blood until the excretion, doing this in a more realistic form and considering not only data from animals but data from human beings as well. For this objective, a workers group of a niobium extraction and processing industry exposed to stable niobium (93 Nb) in oxide insoluble form with associated uranium, was monitored for uranium and niobium determination in urinary and fecal excretion, by mass spectrometry. Based in the ratios of the niobium concentration in urinary and faecal excretion of this workers and animal data study, a new biokinetic model for niobium was proposed, with the followings modifications relative to ICRP model: a new compartment that represents muscular tissue; the fractions which are deposited into the compartment are modified; a third component in the retention equation of the bone tissue; introduction of recirculation between organs and blood. The new model was applied for a case of accidental intake and described adequately the experimental data.

  11. Combining computational fluid dynamics with a biokinetic model for predicting ammonia and phosphate behavior in aeration tanks.

    Science.gov (United States)

    Zima, Piotr; Makinia, Jacek; Swinarski, Marek; Czerwionka, Krzysztof

    2009-11-01

    The aim of this study was to use computational fluid dynamics for predicting the behavior of reactive pollutants (ammonia and phosphate) in the aerobic zone of the bioreactor located at the Wschod wastewater treatment plant in Gdansk, Poland. The one-dimensional advection-dispersion equation was combined with simple biokinetic models incorporating the Monod-type expressions as source terms for the two pollutants. The problem was solved numerically by a multi-step splitting technique algorithm. The dispersion coefficient, E(L), was estimated using a statistical method and numerical optimization based on experimental data from three tracer studies. With the first method, the values of EL varied within the range 1082 to 1860 m2/h and 695 to 1355 m2/h, respectively, in sections 1 and 2 of the aerobic zone. Except for one case, deviations of the corresponding numerically optimized values of E(L) did not exceed 14%. The maximum specific rates of nitrification [r(n,max,20) = 4.6 g N/(kg VSS h)] and phosphate uptake [r(Pupt,max,20) = 13.5 g P/(kg VSS h)] at T = 20 degrees C were determined based on laboratory batch experiments. With minor adjustments of the kinetic parameters, the model was capable of accurately predicting the longitudinal profiles of ammonia and phosphate in the aerobic zone, and the simulation results were presented using the actual horizontal geometry of the bioreactor as a background.

  12. Quantitative biokinetic analysis of radioactively labelled, inhaled Titanium dioxide Nanoparticles in a rat model

    International Nuclear Information System (INIS)

    Kreyling, Wolfgang G.; Wenk, Alexander; Semmler-Behnke, Manuela

    2010-01-01

    The aim of this project was the determination of the biokinetics of TiO 2 nanoparticles (NP) in the whole body of healthy adult rats after NP administration to the respiratory tract - either via inhalation or instillation. We developed an own methodology to freshly synthesize and aerosolize TiO 2 -NP in our lab for the use of inhalation studies. These NP underwent a detailed physical and chemical characterization providing pure polycrystalline anatase TiO 2 -NP of about 20 nm (geometric standard deviation 1.6) and a specific surface area of 270 m 2 /g. In addition, we developed techniques for sufficiently stable radioactive 48 V labelling of the TiO 2 NP. The kinetics of solubility of 48 V was thoroughly determined. The methodology of quantitative biokinetics allows for a quantitative balance of the retained and excreted NP in control of the administered NP dose and provides a much more precise determination of NP fractions and concentrations of NP in organs and tissues of interest as compared to spotting biokinetics studies. Small fractions of TiO 2 -NP translocate across the air-blood-barrier and accumulate in secondary target organs, soft tissue and skeleton. The amount of translocated TiO 2 -NP is approximately 2% of TiO 2 -NP deposited in the lungs. A prominent fraction of these translocated TiO 2 -NP was found in the remainder. Smaller amounts of TiO 2 -NP accumulate in secondary organs following particular kinetics. TiO 2 -NP translocation was grossly accomplished within the first 2-4 hours after inhalation followed by retention in all organs and tissues studied without any detectable clearance of these biopersistent TiO 2 -NP within 28 days. Therefore, our data suggest crossing of the air-blood-barrier of the lungs and subsequent accumulation in secondary organs and tissues depends on the NP material and its physico-chemical properties. Furthermore, we extrapolate that during repeated or chronic exposure to insoluble NP the translocated fraction of NP will

  13. Comparison of predicted with observed biokinetics of inhaled plutonium nitrate and gadolinium oxide in humans

    International Nuclear Information System (INIS)

    Hodgson, A.; Shutt, A.L.; Etherington, G.; Hodgson, S.A.; Rance, E.; Stradling, G.N.; Youngman, M.J.; Ziesenis, A.; Kreyling, W.G.

    2003-01-01

    The absorption kinetics to blood of plutonium and gadolinium after inhalation as nitrate and oxide in humans and animals has been studied. For each material, values describing the time dependence of absorption were derived from the studies in animals and used with the ICRP human respiratory tract model to predict lung retention and cumulative amounts to blood for the volunteers inhaling the same materials. Comparison with the observed behaviour in the volunteers suggests that absorption of plutonium and gadolinium is reasonably species independent, and that data obtained from animal studies can be used to assess their biokinetic behaviour in humans. (author)

  14. Quantitative biokinetic analysis of radioactively labelled, inhaled Titanium dioxide Nanoparticles in a rat model

    Energy Technology Data Exchange (ETDEWEB)

    Kreyling, Wolfgang G.; Wenk, Alexander; Semmler-Behnke, Manuela [Helmholtz Zentrum Muenchen, Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH (Germany). Inst. fuer Lungenbiologie und Erkrankungen, Netzwerk Nanopartikel und Gesundheit

    2010-09-15

    The aim of this project was the determination of the biokinetics of TiO{sub 2} nanoparticles (NP) in the whole body of healthy adult rats after NP administration to the respiratory tract - either via inhalation or instillation. We developed an own methodology to freshly synthesize and aerosolize TiO{sub 2}-NP in our lab for the use of inhalation studies. These NP underwent a detailed physical and chemical characterization providing pure polycrystalline anatase TiO{sub 2}-NP of about 20 nm (geometric standard deviation 1.6) and a specific surface area of 270 m{sup 2}/g. In addition, we developed techniques for sufficiently stable radioactive {sup 48}V labelling of the TiO{sub 2} NP. The kinetics of solubility of {sup 48}V was thoroughly determined. The methodology of quantitative biokinetics allows for a quantitative balance of the retained and excreted NP in control of the administered NP dose and provides a much more precise determination of NP fractions and concentrations of NP in organs and tissues of interest as compared to spotting biokinetics studies. Small fractions of TiO{sub 2}-NP translocate across the air-blood-barrier and accumulate in secondary target organs, soft tissue and skeleton. The amount of translocated TiO{sub 2}-NP is approximately 2% of TiO{sub 2}-NP deposited in the lungs. A prominent fraction of these translocated TiO{sub 2}-NP was found in the remainder. Smaller amounts of TiO{sub 2}-NP accumulate in secondary organs following particular kinetics. TiO{sub 2}-NP translocation was grossly accomplished within the first 2-4 hours after inhalation followed by retention in all organs and tissues studied without any detectable clearance of these biopersistent TiO{sub 2}-NP within 28 days. Therefore, our data suggest crossing of the air-blood-barrier of the lungs and subsequent accumulation in secondary organs and tissues depends on the NP material and its physico-chemical properties. Furthermore, we extrapolate that during repeated or chronic

  15. Biokinetics aand dosimetry of inhaled 238PuO2 in the beagle dog: An update

    International Nuclear Information System (INIS)

    Guilmette, R.A.; Griffith, W.C.; Diel, J.H.

    1994-01-01

    The temporal and spatial distributions of 238 Pu have been measured during the course of a dose-response study of the biological effects of inhaled 238 PuO 2 in Beagle dogs. These measurements were done on the dose-response study animals, as well as a separate group of dogs exposed to similar aerosols and killed serially out to 4 y after exposure. The data from this latter group provided the basis for the development of a biokinetic/dosimetric model for 238 PuO 2 in dogs. Since the publication of this model, several important findings have been made that affected the dosimetric evaluations. The first involved the discovery of significant quantities of natural uranium (U) in the feces samples. The U was measured with the plutonium (Pu), which inflated the values for purported Pu in feces. The second finding involved the addition of Pu biokinetics data from the dose-response dogs, which increased the period of observation from 4 y to 15 y; these later data were not consistent with the earlier model predictions. The purpose of this investigation was (1) to remove the analytical bias in the 238 Pu radiochemical data due to the U and (2) to modify the original model of Mewhinney and Diel, taking into account all data from both studies

  16. Uranium: biokinetics and toxicity; Biocinetique et toxicite de l'uranium

    Energy Technology Data Exchange (ETDEWEB)

    Menetrier, F.; Renaud-Salis, V.; Flury-Herard, A

    2000-07-01

    This report was achieved as a part of a collaboration with the Fuel Cycle Direction. Its aim was to give the state of the art about: the behaviour of uranium in the human organism (biokinetics) after ingestion, its toxicity (mainly renal) and the current regulation about its incorporation. Both in the upstream and in the downstream of the fuel cycle, uranium remains, quantitatively, the first element in the cycle which is, at the present time, temporarily disposed or recycled. Such a considerable quantity of uranium sets the problem of its risk on the health. In the long term, the biosphere may be affected and consequently the public may ingest water or food contaminated with uranium. In this way, radiological and chemical toxicity risk may be activated. This report emphasizes: the necessity of confirming some experimental and epidemiological biokinetic data used or not in the ICRP models. Unsolved questions remain about the gastrointestinal absorption according to chemical form (valency state, mixtures...), mass and individual variations (age, disease) further a chronic ingestion of uranium. It is well established that uranium is mainly deposited in the skeleton and the kidney. But the skeleton kinetics following a chronic ingestion and especially in some diseases has to be more elucidated; the necessity of taking into account uranium at first as a chemical toxic, essentially in the kidney and determining the threshold of functional lesion. In this way, it is important to look for some specific markers; the problem of not considering chemical toxicity of uranium in the texts regulating its incorporation.

  17. Relevance of the ICRP biokinetic model for dietary organically bound tritium

    International Nuclear Information System (INIS)

    Trivedi, A.

    1999-10-01

    Ingested dietary tritium can participate in metabolic processes, and become synthesized into organically bound tritium in the tissues and organs. The distribution and retention of the organically bound tritium throughout the body are much different than tritium in the body water. The International Commission on Radiological Protection (ICRP) Publication 56 (1989) has a biokinetic model to calculate dose from the ingestion of organically bound dietary tritium. The model predicts that the dose from the ingestion of organically bound dietary tritium is about 2.3 times higher than from the ingestion of the same activity of tritiated water. Under steady-state conditions, the calculated dose rate (using the first principle approach) from the ingestion of dietary organically bound tritium can be twice that from the ingestion of tritiated water. For an adult, the upper-bound dose estimate for the ingestion of dietary organically bound tritium is estimated to be close to 2.3 times higher than that of tritiated water. Therefore, given the uncertainty in the dose calculation with respect to the actual relevant dose, the ICRP biokinetic model for organically bound tritium is sufficient for dosimetry for adults. (author)

  18. A multiple-compartment model for biokinetics studies in plants

    International Nuclear Information System (INIS)

    Garcia, Fermin; Pietrobron, Flavio; Fonseca, Agnes M.F.; Mol, Anderson W.; Rodriguez, Oscar; Guzman, Fernando

    2001-01-01

    In the present work is used the system of linear equations based in the general Assimakopoulos's GMCM model , for the development of a new method that will determine the flow's parameters and transfer coefficients in plants. The need of mathematical models to quantify the penetration of a trace substance in animals and plants, has often been stressed in the literature. Usually, in radiological environment studies, it is used the mean value of contaminant concentrations on whole or edible part plant body, without taking in account vegetable physiology regularities. In this work concepts and mathematical formulation of a Vegetable Multi-compartment Model (VMCM), taking into account the plant's physiology regularities is presented. The model based in general ideas of the GMCM , and statistical Square Minimum Method STATFLUX is proposed to use in inverse sense: the experimental time dependence of concentration in each compartment, should be input, and the parameters should be determined from this data in a statistical approach. The case of Uranium metabolism is discussed. (author)

  19. Comparison between two clones of Daphnia magna: effects of multigenerational cadmium exposure on toxicity, individual fitness, and biokinetics.

    Science.gov (United States)

    Guan, Rui; Wang, Wen-Xiong

    2006-03-10

    We investigated the effects of genotype (two different clones) and multigenerational Cd-exposure history on Cd toxicity, individual fitness, and biokinetics in populations of a freshwater cladoceran Daphnia magna. The adults of the tolerant (T) clone had longer mean-survival-time than the sensitive (S) clone in both control groups (without Cd-exposure) and continuous Cd-exposure groups, but the two clones showed comparable resistances to acute Cd stress in the recovery groups. The body concentration of metallothionein (MT) played a critical role in handling Cd stress, which mainly accounted for the significant difference between the two clones in terms of survival distribution. High comparability of these two clones in individual fitness parameters and biokinetics suggested that these parameters are unlikely driven by genetic variation. For each specific clone, continuous Cd-exposure inhibited the animal growth, elevated the MT induction, and increased the Cd uptake rate (ingestion rate, assimilation efficiency from dietary phase, and uptake rate from dissolved phase), all of which enhanced the weight-specific Cd accumulation in daphnids' bodies. The strong dependence of biokinetic parameters on environmental factors (e.g., food concentrations, pH, dissolved or dietary metal concentration, and metal exposure histories) rather than on genotypes implied the great potential of using biokinetics in inter-lab comparisons and environmental risk assessments.

  20. Depth investigation of rapid sand filters for drinking water production reveals strong stratification in nitrification biokinetic behavior

    DEFF Research Database (Denmark)

    Tatari, Karolina; Smets, Barth F.; Albrechtsen, Hans-Jørgen

    2016-01-01

    The biokinetic behavior of NH4 + removal was investigated at different depths of a rapid sand filter treating groundwater for drinking water preparation. Filter materials from the top, middle and bottom layers of a full-scale filter were exposed to various controlled NH4 + loadings in a continuous...

  1. Comparison between two clones of Daphnia magna: Effects of multigenerational cadmium exposure on toxicity, individual fitness, and biokinetics

    International Nuclear Information System (INIS)

    Guan Rui; Wang Wenxiong

    2006-01-01

    We investigated the effects of genotype (two different clones) and multigenerational Cd-exposure history on Cd toxicity, individual fitness, and biokinetics in populations of a freshwater cladoceran Daphnia magna. The adults of the tolerant (T) clone had longer mean-survival-time than the sensitive (S) clone in both control groups (without Cd-exposure) and continuous Cd-exposure groups, but the two clones showed comparable resistances to acute Cd stress in the recovery groups. The body concentration of metallothionein (MT) played a critical role in handling Cd stress, which mainly accounted for the significant difference between the two clones in terms of survival distribution. High comparability of these two clones in individual fitness parameters and biokinetics suggested that these parameters are unlikely driven by genetic variation. For each specific clone, continuous Cd-exposure inhibited the animal growth, elevated the MT induction, and increased the Cd uptake rate (ingestion rate, assimilation efficiency from dietary phase, and uptake rate from dissolved phase), all of which enhanced the weight-specific Cd accumulation in daphnids' bodies. The strong dependence of biokinetic parameters on environmental factors (e.g., food concentrations, pH, dissolved or dietary metal concentration, and metal exposure histories) rather than on genotypes implied the great potential of using biokinetics in inter-lab comparisons and environmental risk assessments

  2. Biokinetic behavior of Tc in the red abalone, Haliotis rufescens: a reassessment

    International Nuclear Information System (INIS)

    Beasley, T.M.; Lorz, H.V.; Gonor, J.J.

    1981-01-01

    The biokinetic behavior of /sup 95m/Tc in the red abalone, Haliotis rufescens, is reviewed in light of recent experiments on other molluscs. Additional experimentation has confirmed that, when uptake is directly from labeled seawater, abalone exhibit concentration factors in excess of 100. Bivalve molluscs under the same experimental conditions have concentration factors that do not exceed 2. However, uptake and loss kinetics cannot be described by a single compartment model as had been previously advanced. Assimilation of /sup 95m/Tc by the abalone following a single feeding of labeled macroalga, Nereocystis pyrifera, is high (approx. 45%) and loss kinetics are similar to those observed following direct uptake from seawater

  3. Biokinetics of carbohydrate and lipid matabolism in normal laying hen; pt. 3

    International Nuclear Information System (INIS)

    Chiang, Y.H.; Riis, P.M.

    1979-01-01

    The radiochemical purity of sup(14)C(U)-glucose solution to be injected to normal laying hen was investigated for studying biokinetics of carbohydrate and lipid metabolism. The liquid scintillation counter was employed for determining the activity of carbon-14. The barium hydroxide and zinc sulfate were adopted to precipitate the protein in the solution. The glucose content in the solution was observed as 0.912 mg per ml. applying Hultman's method. The specific activity of sup(14)C(U)-glucose solution was known as 31.3 nCi/mg glucose. The glucose pentaacetate was synthesized to isolate the pure glucose from the solution. The specific activity of pure glucose was measured as 28.5 nCi/mg glucose. Therefore, it was known that the radiochemical purity of the solution was 82.7%. (Author)

  4. From Technique of Tattooing to Biokinetics and Toxicology of Injected Tattoo Ink Particles and Chemicals

    DEFF Research Database (Denmark)

    Serup, Jørgen

    2017-01-01

    Tattoo colourants are colourful nano- and microparticles, which are practically insoluble and thus permanent once installed in the dermis by the tattooist. Tattoo ink also has soluble ingredients and contaminants. Pigments can distribute via the lymph and possibly also directly to the blood......, and a minute fraction may over time undergo metabolic breakdown and as hapten(s) induce allergic reactions of red tattoos. Carbon black of black tattoos has a tendency to agglomerate and form larger bodies that can elicit foreign body reactions in black tattoos and even granuloma formation with overlap...... to sarcoidosis in the clinic. Very little is known about the biokinetics and safety profile of the many tattoo pigments in use, and no specific pigment-related chemical of tattoo ink causing identified adverse reactions in humans has been depicted. Inks have many ingredients and contaminants. Insoluble...

  5. Selenium-75 and technetium-95m biokinetics in rats at different physiological states

    International Nuclear Information System (INIS)

    Archimbaud, Yves; Grillon, Gerard; Poncy, Jean-Luc; Masse, Roland

    1992-06-01

    Selenium 79 ( 79 Se) and technetium ( 99 Tc), beta emitters, components of nuclear wastes, may increase the dose equivalent to members of the public. Data used by ICRP show that there is relatively little information on Te and Se biokinetics at different physiologic stages. Retention was almost equivalent for young, male adult and pregnant rat. Selenium was concentrated in the testis, the kidneys, the liver and the spleen as technetium was in the skin, the thyroid and the kidneys. The biological half-time for Se and Te was respectively 20 and 41 days for pregnant rats, 33 and 15 days for young rats. Placental transfer per one fetus was 0.56% of the initial activity for Te and 1.27% for Se. These data point out the eventually high doses delivered to the skin for Te and to the testis for Se. They may be taken into consideration in estimating risk by humans at different stages of life [fr

  6. Calibration of hydrodynamic behavior and biokinetics for TOC removal modeling in biofilm reactors under different hydraulic conditions.

    Science.gov (United States)

    Zeng, Ming; Soric, Audrey; Roche, Nicolas

    2013-09-01

    In this study, total organic carbon (TOC) biodegradation was simulated by GPS-X software in biofilm reactors with carriers of plastic rings and glass beads under different hydraulic conditions. Hydrodynamic model by retention time distribution and biokinetic measurement by in-situ batch test served as two significant parts of model calibration. Experimental results showed that TOC removal efficiency was stable in both media due to the enough height of column, although the actual hydraulic volume changed during the variation of hydraulic condition. Simulated TOC removal efficiencies were close to experimental ones with low theil inequality coefficient values (below 0.15). Compared with glass beads, more TOC was removed in the filter with plastic rings due to the larger actual hydraulic volume and lower half saturation coefficient in spite of its lower maximum specific growth rate of biofilm, which highlighted the importance of calibrating hydrodynamic behavior and biokinetics. Copyright © 2013 Elsevier Ltd. All rights reserved.

  7. Intercomparison and biokinetic model validation of radionuclide intake assessment. Report of a co-ordinated research project. 1996-1998

    International Nuclear Information System (INIS)

    1999-03-01

    This TECDOC presents the results of a Co-ordinated Research Project (CRP) on Intercomparison and Biokinetic Model Validation of Radionuclide Intake Assessment, including the conclusions of a Research Co-ordination Meeting held from 6 to 8 July 1998. The present CRP on Intercomparison and Biokinetic Model Validation of Radionuclide Intake Assessment is part of the activities of the IAEA's Occupational Protection programme. The objective of this programme is to promote an internationally harmonized approach for optimizing occupational radiation protection through: the development of guides, within the IAEA's activities for establishing standards for radiation protection, for restricting radiation exposures in the workplace and for applying current occupational radiation protection techniques; and the promotion of application of these guidelines

  8. INDOSE V2.1.1, Internal Dosimetry Code Using Biokinetics Models

    International Nuclear Information System (INIS)

    Silverman, Ido

    2002-01-01

    A - Description of program or function: InDose is an internal dosimetry code developed to enable dose estimations using the new biokinetic models (presented in ICRP-56 to ICRP71) as well as the old ones. The code is written in FORTRAN90 and uses the ICRP-66 respiratory tract model and the ICRP-30 gastrointestinal tract model as well as the new and old biokinetic models. The code has been written in such a way that the user is able to change any of the parameters of any one of the models without recompiling the code. All the parameters are given in well annotated parameters files that the user may change and the code reads during invocation. As default, these files contains the values listed in ICRP publications. The full InDose code is planed to have three parts: 1) the main part includes the uptake and systemic models and is used to calculate the activities in the body tissues and excretion as a function of time for a given intake. 2) An optimization module for automatic estimation of the intake for a specific exposure case. 3) A module to calculate the dose due to the estimated intake. Currently, the code is able to perform only its main task (part 1) while the other two have to be done externally using other tools. In the future we would like to add these modules in order to provide a complete solution for the people in the laboratory. The code has been tested extensively to verify the accuracy of its results. The verification procedure was divided into three parts: 1) verification of the implementation of each model, 2) verification of the integrity of the whole code, and 3) usability test. The first two parts consisted of comparing results obtained with InDose to published results for the same cases. For example ICRP-78 monitoring data. The last part consisted of participating in the 3. EIE-IDA and assessing some of the scenarios provided in this exercise. These tests where presented in a few publications. It has been found that there is very good agreement

  9. Biokinetics and dosimetry of target-specific radiopharmaceuticals for molecular imaging and therapy

    Energy Technology Data Exchange (ETDEWEB)

    Ferro F, G.; Torres G, E. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico); Gonzalez V, A. [UAEM, Facultad de Medicina, Toluca (Mexico); Murphy, C.A. de [INCMNSZ, Mexico D.F. (Mexico)

    2006-07-01

    Molecular imaging techniques directly or indirectly monitor and record the spatiotemporal distribution of molecular or cellular processes for biochemical, biologic, diagnostic or therapeutic applications. {sup 99m}Tc-HYNlC-TOC has shown high in vitro and in vivo stability, rapid background clearance and rapid detection of somatostatin receptor-positive tumors. Therapies using radiolabeled anti-CD20 have demonstrated their efficacy in patients with B-cell non Hodgkin's Iymphoma (NHL). The aim of this study was to establish biokinetic models for {sup 99m}Tc-HYNlC-TOC and {sup 188}Re-anti-CD20 prepared from Iyophilized kits, and to evaluate their dosimetry as target-specific radiopharmaceuticals. Whole-body images were acquired at different times after {sup 99m}Tc-HYNlC-TOC or {sup 188}Re-anti-CD20 administration obtained from instant freeze-dried kit formulations with radiochemical purities > 95 %. Regions of interest (ROls) were drawn around source organs on each time frame. The cpm of each ROI was converted to activity using the conjugate view counting method. The image sequence was used to extrapolate time-activity curves in each organ, to adjust the biokinetic model using the SAAM software, and to calculate the total number of disintegrations (N) that occurred in the source regions. N data were the input for the OLINDA/EXM code to calculate internal radiation dose estimates. {sup 99m}Tc-HYNlC-TOC images showed an average tumor/blood (heart) ratio of 4.3 {+-} 0.7 in receptor-positive tumors at 1 h and the mean radiation absorbed dose calculated for a study using 740 MBq was 24, 21.5, 5.5 and 1.0 mSv for spleen, kidneys, liver and bone marrow respectively and the effective dose was 4.4 mSv. Results showed that after administration of 7 GBq of {sup 188}Re-anti-CD20 the absorbed dose to whole body would be 0.7 Gy (0.1 mGy/MBq) which is the indicated dose for non Hodgkin's Iymphome therapies. (Author)

  10. Quantitative biokinetics of titanium dioxide nanoparticles after intratracheal instillation in rats: Part 3.

    Science.gov (United States)

    Kreyling, Wolfgang G; Holzwarth, Uwe; Haberl, Nadine; Kozempel, Ján; Wenk, Alexander; Hirn, Stephanie; Schleh, Carsten; Schäffler, Martin; Lipka, Jens; Semmler-Behnke, Manuela; Gibson, Neil

    2017-05-01

    The biokinetics of a size-selected fraction (70 nm median size) of commercially available and 48 V-radiolabeled [ 48 V]TiO 2 nanoparticles has been investigated in healthy adult female Wistar-Kyoto rats at retention time-points of 1 h, 4 h, 24 h, 7 d and 28 d after intratracheal instillation of a single dose of an aqueous [ 48 V]TiO 2 -nanoparticle suspension. A completely balanced quantitative biodistribution in all organs and tissues was obtained by applying typical [ 48 V]TiO 2 -nanoparticle doses in the range of 40-240 μg·kg -1 bodyweight and making use of the high sensitivity of the radiotracer technique. The [ 48 V]TiO 2 -nanoparticle content was corrected for residual blood retained in organs and tissues after exsanguination and for 48 V-ions not bound to TiO 2 -nanoparticles. About 4% of the initial peripheral lung dose passed through the air-blood-barrier after 1 h and were retained mainly in the carcass (4%); 0.3% after 28 d. Highest organ fractions of [ 48 V]TiO 2 -nanoparticles present in liver and kidneys remained constant (0.03%). [ 48 V]TiO 2 -nanoparticles which entered across the gut epithelium following fast and long-term clearance from the lungs via larynx increased from 5 to 20% of all translocated/absorbed [ 48 V]TiO 2 -nanoparticles. This contribution may account for 1/5 of the nanoparticle retention in some organs. After normalizing the fractions of retained [ 48 V]TiO 2 -nanoparticles to the fraction that reached systemic circulation, the biodistribution was compared with the biodistributions determined after IV-injection (Part 1) and gavage (GAV) (Part 2). The biokinetics patterns after IT-instillation and GAV were similar but both were distinctly different from the pattern after intravenous injection disproving the latter to be a suitable surrogate of the former applications. Considering that chronic occupational inhalation of relatively biopersistent TiO 2 -particles (including nanoparticles) and accumulation in

  11. Biokinetics and dosimetry of target-specific radiopharmaceuticals for molecular imaging and therapy

    International Nuclear Information System (INIS)

    Ferro F, G.; Torres G, E.; Gonzalez V, A.; Murphy, C.A. de

    2006-01-01

    Molecular imaging techniques directly or indirectly monitor and record the spatiotemporal distribution of molecular or cellular processes for biochemical, biologic, diagnostic or therapeutic applications. 99m Tc-HYNlC-TOC has shown high in vitro and in vivo stability, rapid background clearance and rapid detection of somatostatin receptor-positive tumors. Therapies using radiolabeled anti-CD20 have demonstrated their efficacy in patients with B-cell non Hodgkin's Iymphoma (NHL). The aim of this study was to establish biokinetic models for 99m Tc-HYNlC-TOC and 188 Re-anti-CD20 prepared from Iyophilized kits, and to evaluate their dosimetry as target-specific radiopharmaceuticals. Whole-body images were acquired at different times after 99m Tc-HYNlC-TOC or 188 Re-anti-CD20 administration obtained from instant freeze-dried kit formulations with radiochemical purities > 95 %. Regions of interest (ROls) were drawn around source organs on each time frame. The cpm of each ROI was converted to activity using the conjugate view counting method. The image sequence was used to extrapolate time-activity curves in each organ, to adjust the biokinetic model using the SAAM software, and to calculate the total number of disintegrations (N) that occurred in the source regions. N data were the input for the OLINDA/EXM code to calculate internal radiation dose estimates. 99m Tc-HYNlC-TOC images showed an average tumor/blood (heart) ratio of 4.3 ± 0.7 in receptor-positive tumors at 1 h and the mean radiation absorbed dose calculated for a study using 740 MBq was 24, 21.5, 5.5 and 1.0 mSv for spleen, kidneys, liver and bone marrow respectively and the effective dose was 4.4 mSv. Results showed that after administration of 7 GBq of 188 Re-anti-CD20 the absorbed dose to whole body would be 0.7 Gy (0.1 mGy/MBq) which is the indicated dose for non Hodgkin's Iymphome therapies. (Author)

  12. Biokinetics of 13C in the human body after oral administration of 13C-labeled glucose as an index for the biokinetics of 14C.

    Science.gov (United States)

    Masuda, Tsuyoshi; Tako, Yasuhiro; Matsushita, Kensaku; Takeda, Hiroshi; Endo, Masahiro; Nakamura, Yuji; Hisamatsu, Shun'ichi

    2016-09-01

    The retention of 13 C in the human body after oral administration of 13 C-labeled glucose was studied in three healthy volunteer subjects to estimate the 50 year cumulative body burden for 13 C as an index of the committed dose of the radioisotope 14 C. After administration of 13 C-labeled glucose, the volunteers ingested controlled diets with a fixed number of calories for 112 d. Samples of breath and urine were collected up to 112 d after administration. Samples of feces were collected up to 14 d after administration. Hair samples were obtained at 119 d after administration and analyzed as a representative index of the rate of excretion of organic 13 C via pathways such as skin cell exfoliation and mucus secretion. All samples were analyzed for 13 C/ 12 C atomic ratio to determine the rate of excretion via each pathway. We then constructed a metabolic model with a total of four pathways (breath, urine, feces, and other) comprising seven compartments. We determined the values of the biokinetic parameters in the model by using the obtained excretion data. From 74% to 94% of the 13 C administered was excreted in breath, whereas    0.1). In addition, the dataset for one of the three subjects was markedly different from those of the other two. When we estimated the 50 year cumulative body burden for 13 C by using our model and we included non-statistically significant parameters, a considerable cumulative body burden was found in the compartments excreting to the other pathway. Although our results on the cumulative body burden of 13 C from orally administered carbon as glucose were inconclusive, we found that the compartments excreting to the other pathway had a markedly long residence time and therefore should be studied further to clarify the fate of carbon in the human body. In addition to excreta, data for serum and blood cell samples were also collected from the subjects to examine the metabolism of 13 C in human body.

  13. Physiologically based pharmacokinetics model for estimating urinary excretion of short half-life nuclides in nuclear medicine

    International Nuclear Information System (INIS)

    Akahane, K.; Kai, M.; Konishi, E.; Kusama, T.; Aoki, Y.

    1995-01-01

    The biokinetic model in ICRP 53 is used for calculating absorbed dose to each organ of a patient in nuclear medicine. The ICRP model is a simple compartment model based on human data; however, the model cannot produce the biokinetics of radiopharmaceuticals under various physiological conditions. On the other hand, a physiologically based pharmacokinetics model (PBPK model) can describe the flow of radiopharmaceuticals as a compartment model for any physiological conditions theoretically. The PBPK model was applied especially for the kidney-bladder dynamics, and similar results obtained compared with the ICRP model. This suggests the possibility of the PBPK model for predicting the biokinetics of radiopharmaceuticals under various physiological conditions. (Author)

  14. Excretion of radionuclides in human breast milk after nuclear medicine examinations. Biokinetic and dosimetric data and recommendations on breastfeeding interruption

    Energy Technology Data Exchange (ETDEWEB)

    Leide-Svegborn, Sigrid; Ahlgren, Lars; Mattsson, Soeren [Lund University, Department of Medical Radiation Physics, Skaane University Hospital, Malmoe (Sweden); Johansson, Lennart [Umeaa University, Department of Radiation Sciences, Umeaa (Sweden)

    2016-05-15

    To review early recommendations and propose guidelines for breastfeeding interruption after administration of radiopharmaceuticals, based on additional biokinetic and dosimetric data. Activity concentrations in breast milk from 53 breastfeeding patients were determined. The milk was collected at various times after administration of 16 different radiopharmaceuticals. The fraction of the activity administered to the mother excreted in the breast milk, the absorbed doses to various organs and tissues and the effective dose to the infant were estimated. The fraction of the administered activity excreted per millilitre of milk varied widely from 10{sup -10} to 10{sup -3} MBq/MBq administered. For {sup 99m}Tc-labelled radiopharmaceuticals, the total fraction of the administered activity excreted in the milk varied from 0.0057 % for {sup 99m}Tc-labelled red blood cells (RBC) to 19 % for {sup 99m}Tc-pertechnetate. The effective dose to an infant per unit activity administered to the mother ranged from 6.7 x 10{sup -6} mSv/MBq for {sup 99m}Tc-labelled RBC to 3.6 x 10{sup -2} mSv/MBq for {sup 99m}Tc-pertechnetate. For the other radiopharmaceuticals, the total fraction of administered activity excreted in the milk varied from 0.018 % ({sup 51}Cr-EDTA) to 48 % ({sup 131}I-NaI). The effective dose ranged from 5.6 x 10{sup -5} mSv{sub infant}/MBq{sub mother} ({sup 51}Cr-EDTA) to 106 mSv{sub infant}/MBq{sub mother} ({sup 131}I-NaI). Based on an effective dose limit of 1 mSv to the infant and a typical administered activity, we recommend cessation of breastfeeding for {sup 131}I-NaI and interruption of feeding for 12 h for {sup 125}I-iodohippurate, {sup 131}I-iodohippurate, {sup 99m}Tc-pertechnetate and {sup 99m}Tc-MAA. During this 12-h period all breast milk should be expressed at least three times and discarded. For the other radiopharmaceuticals included in this study, no interruption of breastfeeding is necessary. (orig.)

  15. Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods

    OpenAIRE

    Berggren, Elisabet; White, Andrew; Ouedraogo, Gladys; Paini, Alicia; Richarz, Andrea-Nicole; Bois, Frederic Y.; Exner, Thomas; Leite, Sofia; Grunsven, Leo A. van; Worth, Andrew; Mahony, Catherine

    2017-01-01

    Highlights • A workflow for an exposure driven chemical safety assessment to avoid animal testing. • Hypothesis based on existing data, in silico modelling and biokinetic considerations. • A tool to inform targeted and toxicologically relevant in vitro testing.

  16. Uniquely high turnover of nickel in contaminated oysters Crassostrea hongkongensis: Biokinetics and subcellular distribution.

    Science.gov (United States)

    Yin, Qijun; Wang, Wen-Xiong

    2018-01-01

    Despite the environmental concerns regarding nickel (Ni) especially in China, it has received little attention in aquatic animals due to its comparatively weak toxicity. In the present study, we explored the bioaccumulation, biokinetics, and subcellular distribution of Ni in an estuarine oyster Crassostrea hongkongensis. We demonstrated that Ni represented a new pattern of bioaccumulation in oysters characterized by rapid elimination and low dissolved uptake. The waterborne uptake rate constant and dietary assimilation efficiency were 0.036L/g/h and 28%, respectively, and dissolved uptake was the predominant exposure route. The efflux rate constant was positively related to tissue Ni concentration, with the highest efflux of 0.155d -1 . Such high elimination resulted in a high Ni turnover and steady-state condition reached rapidly, as shown with a 4-week waterborne exposure experiment at different Ni concentrations. Ni in oysters was mainly sequestered in metallothionein-like protein (MTLP), metal-rich granule, and cellular debris. MTLP was the most important binding fraction during accumulation and depuration, and played a dynamic role leading to rapid Ni elimination. Pre-exposure to Ni significantly reduced the dissolved uptake, probably accompanied by depressed filtration activity. Overall, the high turnover and regulation of Ni in oysters were achieved by enhanced efflux, suppressed uptake, and sequestration of most Ni into the detoxified pool. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Biokinetics and dosimetry of Depleted Uranium (DU) in rats implanted with DU fragments

    Energy Technology Data Exchange (ETDEWEB)

    Guilmette, R.A. [Los Alamos National Lab., Los Alamos, NM (United States); Hahn, F.F. [Lovelace Respiratory Research Inst., Albuquerque, NM (United States); Durbin, P.W. [Lawrence Berkeley National Lab., Berkeley, CA (United States)

    2005-07-01

    As part of a lifespan cancer study done in rats (Hahn et al. 2003), four square (5 mm x 5 mm) DU wafers were implanted in the leg muscles of rats for biokinetic studies. Twenty-four hour urine samples were collected periodically, and DU was analyzed in these samples, kidneys and eviscerated carcass. The daily DU urinary excretion rate increased steeply during the first 30 d after implantation, peaking at 60-90 d at 3-10 x 10{sup -3}%/d. During the first 150 d, the average excretion rate was 2.4 x 10{sup -3}%/d, decreasing thereafter to about 1 x 10{sup -3}%/d. Serial radiographs made of the wound sites showed that, as early as 1 w after implantation, surface corrosion and small, dense bodies were present near the original implant, presumably DU, which continued to increase with time. During this 3-mo period, connective tissue capsules also formed around the implants, and are hypothesized to have reduced the access of DU to tissue fluids by limiting the diffusion rate of dissolved chemical forms of DU from the wound site. Using a model of wound-site retention being developed by a committee of the U. S. NCRP, the DU wound retention could be described by a two-component exponential function in which 0.5% of the DU was retained with a half time of 80 d and the remainder with a half time of about 300 y. (orig.)

  18. Investigation on biokinetics of 134Cs and 241Am radionuclides in three different organisms and a new evaluation by using discrete time model

    International Nuclear Information System (INIS)

    Guengoer, N.

    1999-05-01

    In this study, 134 Cs and 241 Am biokinetic experiments have been observed originally for Black Sea condition with using the gastropod Patella coerulea and the macro algae Enteremorpha linza and the common mussel Mytilus galloprovlncialis as bio indicator organisms. The experiments that have at least three originality, have been carried out very carefully and biokinetic parameters have been calculated by using classical model. The results are compared with the proportionally similar experiments in the literature globally. In this thesis, a new model application has proposed for the biokinetic evaluation for loss experiments of organisms. That is discrete time model. Loss experiments can be evaluated proportionally in a quick and easy way by using this model. Then, it can be observed that the calculated decreasing factor (r) by discrete time model, shows the loss process quality. Moreover, the loss experiments can be stopped when the decreasing factor goes to 1. So, the loss experiment can be evaluated rapidly and quickly with the adequate reliability by using discrete time model. Furthermore, the loss process in the organisms becomes slower and biologic half-lives becomes longer, when the decreasing factor (r) goes to 1. On the other hand, the biological depuration rate (k) goes to nearly zero. So, the proposed discrete time model that is applied in this thesis originally for biokinetic, can be evident that it has an adequate reliability for the biokinetic evaluation

  19. 99mTc-exendin(9-39)/octreotide: biokinetics and radiation dosimetry in healthy individuals.

    Science.gov (United States)

    Ocampo-García, Blanca E; Santos-Cuevas, Clara L; Luna-Gutiérrez, Myrna A; Ignacio-Alvarez, Eleazar; Pedraza-López, Martha; Manzano-Mayoral, Cesar

    2017-11-01

    About 90% of insulinomas are benign and 5-15% are malignant. Benign insulinomas express the glucagon-like peptide-1 receptor (GLP-1R, which recognizes exendin-4 and low levels of the somatostatin receptor (SSTR, which recognizes octreotide), whereas malignant insulinomas overexpress SSTR and low levels of GLP-1R. Recently, Lys(Tc-EDDA/HYNIC)-exendin(9-39)/Tc-EDDA/HYNIC-Tyr-octreotide was formulated to detect 100% of insulinomas. The aim of this study was to estimate the biokinetics and dosimetry of Tc-exendin(9-39)/octreotide in four healthy individuals. Tc-exendin(9-39)/octreotide was obtained from a lyophilized formulation with radiochemical purities of more than 97%, determined by reversed-phase high-performance liquid chromatography. Whole-body images from four healthy individuals were acquired at 20 min, 2, 6, and 24 h after Tc-exendin(9-39)/octreotide administration. Regions of interest were drawn around the source organs on each time frame. Each region of interest was corrected by background, attenuation, scattered radiation, and physical decay. The image sequence was used to extrapolate the Tc-exendin(9-39)/octreotide time-activity curves of each organ to adjust the biokinetic model and calculate the total number of disintegrations (N) that occurred in the source regions. N data were the input for the OLINDA/EXM code to calculate internal radiation doses. Furthermore, in a patient suspicious of harboring an insulinoma, whole-body single-photon emission computed tomography/computed tomography images were obtained at 3 h. For four healthy individuals, the blood activity showed a half-life value of 1.20 min for the fast component (T1/2 α=ln 2/34.71), 8.7 min for the first slow component (T1/2 β=ln 2/4.76), and 1.7 h for the second slow component (T1/2 γ=ln 2/0.401). The average equivalent doses calculated for a study using 555 MBq were 15.10, 4.13, 3.08, 2.61, and 1.90 mSv for the kidneys, upper large intestinal wall, lower large

  20. From Technique of Tattooing to Biokinetics and Toxicology of Injected Tattoo Ink Particles and Chemicals.

    Science.gov (United States)

    Serup, Jørgen

    2017-01-01

    Tattoo colourants are colourful nano- and microparticles, which are practically insoluble and thus permanent once installed in the dermis by the tattooist. Tattoo ink also has soluble ingredients and contaminants. Pigments can distribute via the lymph and possibly also directly to the blood, and a minute fraction may over time undergo metabolic breakdown and as hapten(s) induce allergic reactions of red tattoos. Carbon black of black tattoos has a tendency to agglomerate and form larger bodies that can elicit foreign body reactions in black tattoos and even granuloma formation with overlap to sarcoidosis in the clinic. Very little is known about the biokinetics and safety profile of the many tattoo pigments in use, and no specific pigment-related chemical of tattoo ink causing identified adverse reactions in humans has been depicted. Inks have many ingredients and contaminants. Insoluble and soluble ingredients of inks supposedly have very different characteristics of absorption, distribution, metabolism, and excretion, with pigments being extremely slowly excreted, contrasting soluble ingredients with fast elimination. Tattoos are a single-dose exposure. Controlling the safety of tattoo inks by banning potentially critical chemicals hitherto has been unsuccessful due to lacking documentation of clinical and epidemiological relevance and because the tattoo industry is already internationally established, free, and in the ownership of the people. Doctors treating patients with tattoo complications consequently have a key role in identifying risk situations and local outbreaks, which needs clarification, therapy, and the intervention of authorities. In the treatment of complications, as seen in general practice and in other specialties, basic insight into the fate of tattoo pigments in the body is necessary. Tattoo complications are complicated and facetted with many entities and disease mechanisms; they are a new subspecialty in medicine and dermatology. © 2017 S

  1. Radionuclide decorporation: matching the biokinetics of actinides by transdermal delivery of pro-chelators.

    Science.gov (United States)

    Zhang, Yong; Sadgrove, Matthew P; Mumper, Russell J; Jay, Michael

    2013-10-01

    The threat of nuclear terrorism by the deliberate detonation of a nuclear weapon or radiological dispersion device ("dirty bomb") has made emergency response planning a priority. The only FDA-approved treatments for contamination with isotopes of the transuranic elements Am, Pu, and Cm are the Ca and Zn salts of diethylenetriaminepentaacetic acid (DTPA). These injectable products are not well suited for use in a mass contamination scenario as they require skilled professionals for their administration and are rapidly cleared from the circulation. To overcome the mismatch in the pharmacokinetics of the DTPA and the biokinetics of these transuranic elements, which are slowly released from contamination sites, the penta-ethyl ester of DTPA (C2E5) was prepared and formulated in a nonaqueous gel for transdermal administration. When gels comprised of 40% C2E5, 40-45% Miglyol® 840, and 15-20% ethyl cellulose were spiked with [(14)C]-C2E5 and applied to rat skin; over 60% of the applied dose was absorbed within a 24-h period. Radioactivity was observed in urinary and fecal excretions for over 3 days after removal of the gel. Using an (241)Am wound contamination model, transdermal C2E5 gels were able to enhance total body elimination and reduce the liver and skeletal burden of (241)Am in a dose-dependent manner. The efficacy achieved by a single 1,000 mg/kg dose to contaminated rats was statistically comparable to intravenous Ca-DTPA at 14 mg/kg. The effectiveness of this treatment, favorable sustained release profile of pro-chelators, and ease of administration support its use following radiological emergencies and for its inclusion in the Strategic National Stockpile.

  2. Investigation of biokinetics of cadmium in the mussel in various environmental conditions

    International Nuclear Information System (INIS)

    Erdener, B.

    1982-01-01

    The biokinetics of cadmium were investigated under different environmental conditions in mussel (M. galloprovincialis) using sup(115m)Cd as tracer. The accumulation experiment was followed from water for 34 days and observed concentration factor 68 was obtained. On the other hand, it is observed that between the concentrations used in the experiment, the accumulation increased proportionally with the stable cadmium concentration in water. During depuration, more than one compartment has been observed on the loss curves carried out under different temperature and salinity. The results showed that mussels under 22-1 0 C lost cadmium more rapidly at the beginning compared with the ones under 15-1 0 C, which were kept in the same salinity, 0.21%. At the same time, the loss rates were found significantly different under different salinities. For example, the biological half-lives were 407.6 and 866.2 at the salinities 0.21% and 0.7% S respectively. The loss rate of cadmium was also followed under field condition. It is concluded that the results obtained in the field and the laboratory cannot be comparable; for example, the biological half-lives for the slow components in these two experiments were 350 and 612 days respectively. The relative distribution of cadmium in different organs and tissues are examined, it is observed that cadmium both after accumulation and loss periods, is localized in stomach hepatopancreas, gills and mantle. At the end of the accumulation experiment the highest relative percentage of cadmium was 30% in stomach, 22.7% in hepatopancreas. Likely at the end of loss periods the highest percentages of retained cadmium were 42% in stomach and 32% in hepatopancreas. (author)

  3. Radiation fields, dosimetry, biokinetics and biophysical models for cancer induction by ionising radiation 1996-1999. Executive summary

    International Nuclear Information System (INIS)

    Jacob, P.; Paretzke, H.G.; Roth, P.

    2000-01-01

    The Association Contract covers a range of research domains that are important to the Radiation Protection Research Action, especially in the areas 'Evaluation of Radiation Risks' and 'Understanding Radiation Mechanisms and Epidemiology'. Three research projects concentrate on radiation dosimetry research and two projects on the modelling of radiation carcinogenesis. The following list gives an overview on the topics and responsible scientific project leaders of the Association Contract: Study of radiation fields and dosimetry at aviation altitudes. Biokinetics and dosimetry of incorporated radionuclides. Dose reconstruction. Biophysical models for the induction of cancer by radiation. Experimental data for the induction of cancer by radiation of different qualities. (orig.)

  4. Application for internal dosimetry using biokinetic distribution of photons based on nuclear medicine images

    International Nuclear Information System (INIS)

    Leal Neto, Viriato; Vieira, Jose Wilson; Lima, Fernando Roberto de Andrade

    2014-01-01

    Objective: this article presents a way to obtain estimates of dose in patients submitted to radiotherapy with basis on the analysis of regions of interest on nuclear medicine images. Materials and methods: a software called DoRadIo (Dosimetria das Radiacoes Ionizantes [Ionizing Radiation Dosimetry]) was developed to receive information about source organs and target organs, generating graphical and numerical results. The nuclear medicine images utilized in the present study were obtained from catalogs provided by medical physicists. The simulations were performed with computational exposure models consisting of voxel phantoms coupled with the Monte Carlo EGSnrc code. The software was developed with the Microsoft Visual Studio 2010 Service Pack and the project template Windows Presentation Foundation for C ⧣ programming language. Results: with the mentioned tools, the authors obtained the file for optimization of Monte Carlo simulations using the EGSnrc; organization and compaction of dosimetry results with all radioactive sources; selection of regions of interest; evaluation of grayscale intensity in regions of interest; the file of weighted sources; and, finally, all the charts and numerical results. Conclusion: the user interface may be adapted for use in clinical nuclear medicine as a computer-aided tool to estimate the administered activity. (author)

  5. Application for internal dosimetry using biokinetic distribution of photons based on nuclear medicine images

    Energy Technology Data Exchange (ETDEWEB)

    Leal Neto, Viriato, E-mail: viriatoleal@yahoo.com.br [Instituto Federal de Educacao, Ciencia e Tecnologia de Pernambuco (IFPE), Recife, PE (Brazil); Vieira, Jose Wilson [Universidade Federal de Pernambuco (UPE), Recife, PE (Brazil); Lima, Fernando Roberto de Andrade [Centro Regional de Ciencias Nucleares (CRCN-NE/CNEN-PE), Recife, PE (Brazil)

    2014-09-15

    Objective: this article presents a way to obtain estimates of dose in patients submitted to radiotherapy with basis on the analysis of regions of interest on nuclear medicine images. Materials and methods: a software called DoRadIo (Dosimetria das Radiacoes Ionizantes [Ionizing Radiation Dosimetry]) was developed to receive information about source organs and target organs, generating graphical and numerical results. The nuclear medicine images utilized in the present study were obtained from catalogs provided by medical physicists. The simulations were performed with computational exposure models consisting of voxel phantoms coupled with the Monte Carlo EGSnrc code. The software was developed with the Microsoft Visual Studio 2010 Service Pack and the project template Windows Presentation Foundation for C ⧣ programming language. Results: with the mentioned tools, the authors obtained the file for optimization of Monte Carlo simulations using the EGSnrc; organization and compaction of dosimetry results with all radioactive sources; selection of regions of interest; evaluation of grayscale intensity in regions of interest; the file of weighted sources; and, finally, all the charts and numerical results. Conclusion: the user interface may be adapted for use in clinical nuclear medicine as a computer-aided tool to estimate the administered activity. (author)

  6. Application for internal dosimetry using biokinetic distribution of photons based on nuclear medicine images.

    Science.gov (United States)

    Leal Neto, Viriato; Vieira, José Wilson; Lima, Fernando Roberto de Andrade

    2014-01-01

    This article presents a way to obtain estimates of dose in patients submitted to radiotherapy with basis on the analysis of regions of interest on nuclear medicine images. A software called DoRadIo (Dosimetria das Radiações Ionizantes [Ionizing Radiation Dosimetry]) was developed to receive information about source organs and target organs, generating graphical and numerical results. The nuclear medicine images utilized in the present study were obtained from catalogs provided by medical physicists. The simulations were performed with computational exposure models consisting of voxel phantoms coupled with the Monte Carlo EGSnrc code. The software was developed with the Microsoft Visual Studio 2010 Service Pack and the project template Windows Presentation Foundation for C# programming language. With the mentioned tools, the authors obtained the file for optimization of Monte Carlo simulations using the EGSnrc; organization and compaction of dosimetry results with all radioactive sources; selection of regions of interest; evaluation of grayscale intensity in regions of interest; the file of weighted sources; and, finally, all the charts and numerical results. The user interface may be adapted for use in clinical nuclear medicine as a computer-aided tool to estimate the administered activity.

  7. Compared biokinetic and biological studies of chronic and acute inhalations of uranium compounds in the rat; Etudes biocinetique et biologique comparees d'inhalations chroniques et aigues de composes uraniferes chez le rat

    Energy Technology Data Exchange (ETDEWEB)

    Monleau, M

    2005-12-15

    Uranium is a natural, radioactive heavy metal, widely used in the nuclear industry in various chemical and isotopic forms. Its use in the fuel cycle involves the risk of radiological exposure for the workers, mainly via the inhalation of uranium particles. According to the workplace configuration, uranium contaminations can be acute or repeated, involve various chemical forms and different levels of enrichment, as well as involving one or several components. The dosimetric concepts and models available for workers' radiological protection, as well as most of the studies of the biological effects, correspond to acute exposure situations. Moreover the processes leading to pathological effects are little known in vivo. In this context, the main question is to know whether exposures due to repeated inhalation by rats induce the element kinetics and toxicity, which may be different from those observed after an acute exposure. In this study, comparison of the experimental and theoretical biokinetics of an insoluble uranium repeatedly inhaled over three weeks shows that a chronic contamination is correctly modelled, except for bone retention, by the sum of acute, successive and independent incorporations. Moreover, the kinetics of a soluble uranium inhaled irregularly can be modified by previous repeated exposure to an insoluble uranium. In certain cases therefore, exposure to uranium could modify its biokinetics during later exposures. At a toxicological level, the study demonstrates that the uranium particles inhaled repeatedly induce behavioural disruptions and genotoxic effects resulting in various sorts of DNA damage, in several cell types and certainly depending on the quantity inhaled. Exposures involving several uraniferous components produce a synergy effect. Moreover, repeated inhalations worsen the genotoxic effects in comparison to an acute exposure. This work demonstrates the importance of not ignoring the effects of the repetition of uranium exposure

  8. Biokinetic data of various radioactive cationic molecules. An attempt at evaluation of significant chemical properties of myotropic agents

    International Nuclear Information System (INIS)

    Munze, R.; Kretzschmar, M.; Syhre, R.; Kampf, G.; Klotzer, D.; Guthert, I.; Bergmann, R.

    1986-01-01

    Research on lipophilic cationic radiopharmaceuticals has been established as an important field of modern radiopharmacology and experimental nuclear medicine. The present state is best demonstrated by scintigrams obtained with Tc-TBI (TBI = tertiary butylisocyanide). These images clearly reveal the advantage of these compounds, namely high information density, which resulted in an excellent delineation of activity accumulations, as well as the lasting drawback represented by partial overlapping of the right lobe of the liver in a certain region of the inferior wall of the heart. Current research is mainly focused on overcoming this disadvantage by synthesizing appropriate compounds with higher heart/liver uptake in man. A more sophisticated rationale than cationic charge and lipophilicity would be much appreciated. This paper deals with possible correlations between the biodistribution and biokinetics of such compounds, though not exclusively for technetium cations, and their important chemical properties such as composition, size, and polar regions within the lipophilic molecule, which are considered significant parameters

  9. Modeling Aspects of Activated Sludge Processes Part l l: Mathematical Process Modeling and Biokinetics of Activated Sludge Processes

    International Nuclear Information System (INIS)

    AbdElHaleem, H.S.; EI-Ahwany, A. H.; Ibrahim, H.I.; Ibrahim, G.

    2004-01-01

    Mathematical process modeling and biokinetics of activated sludge process were reviewed considering different types of models. It has been evaluated the task group models of ASMI. and 2, and 3 versioned by Henze et al considering the conditions of each model and the different processes of which every model consists. It is revealed that ASMI contains some defects avoided in ASM3. Relied on homogeneity, Models can be classified into homogenous models characterized by taking the activated sludge process as one phase. In this type of models, the internal mass transfer inside the floes was neglected.. Hence, the kinetic parameter produces can be considered inaccurate. The other type of models is the heterogeneous model This type considers the mass transfer operations in addition to the biochemical reaction processes; hence, the resulted kinetic parameters can be considered more accurate than that of homogenous type

  10. Biokinetics and radiation dosimetry of 14C-labelled triolein, urea, glycocholic acid and xylose in man. Studies related to nuclear medicine 'breath tests' using accelerator mass spectrometry

    International Nuclear Information System (INIS)

    Gunnarsson, Mikael

    2002-08-01

    14 C-labelled substances have been used in biomedical research and clinical medicine for over 50 years. Physicians and scientists however, often hesitate to use these substances in patients and volunteers because the radiation dosimetry is unclear. In this work detailed long-term biokinetic and dosimetric estimation have been carried out for four clinically used 14 C-breath tests: 14 C-triolein (examination of fat malabsorption), urea (detection of Helicobacter pylori infection in the stomach), glycocholic acid and xylose (examination of bacterial overgrowth in the small intestine) by using the highly sensitive accelerator mass-spectrometry (AMS) technique. The AMS technique has been used to measure low 14 C concentrations in small samples of exhaled air, urine, faeces and tissue samples and has improved the base for the estimation of the absorbed dose to various organs and tissues and the effective dose to man. The high sensitivity of the AMS system has also made it possible to perform 14 C breath tests on patient groups which were earlier subject for restriction (e.g. small children). In summary, our results show that for adult patients - and in the case of 14 C-urea breath test also for children down to 3 years of age - the dose contributions are comparatively low, both described as organ doses and as effective doses. For adults, the latter is: 14 C-glycocholic acid - 0.4 mSv/MBq, 14 C-triolein - 0.3 mSv/MBq, 14 C-xylose - 0.1 mSv/MBq and 14 C-urea - 0.04 mSv/MBq. Thus, from a radiation protection point of view there is no reason for restrictions in using any of the 14 C-labelled radiopharmaceutical included in this work in the activities normally used (0.07-0.2 MBq for a 70 kg patient)

  11. Intratherapeutic biokinetic measurements, dosimetry parameter estimates, and monitoring of treatment efficacy using cerenkov luminescence imaging in preclinical radionuclide therapy.

    Science.gov (United States)

    Timmermand, Oskar Vilhelmsson; Tran, Thuy A; Strand, Sven-Erik; Axelsson, Johan

    2015-03-01

    In recent years, there has been increasing interest in noninvasive Cerenkov luminescence imaging (CLI) of in vivo radionuclide distribution in small animals, a method proven to be a high-throughput modality for confirmation of tracer uptake. 11B6 is an IgG1 monoclonal antibody that is specific to free human kallikrein-related peptidase 2, an antigen abundant in malignant prostatic tissue. Free human kallikrein-related peptidase 2 was targeted in prostate cancer xenografts using (177)Lu-labeled 11B6 in either murine or humanized forms for radionuclide therapy. In this setting, CLI was investigated as a tool for providing parameters of dosimetric importance during radionuclide therapy. First, longitudinal imaging of biokinetics using CLI and SPECT was compared. Second, the CLI signal was correlated to quantitative ex vivo tumor activity measurements. Finally, CLI was used to monitor the radionuclide treatment, and the integrated CLI radiance was found to correlate well with subject-specific tumor volume reduction. 11B6 was radiolabeled with (177)Lu through the CHX-A″-DTPA chelator. In vivo CLI and SPECT imaging of (177)Lu-DTPA-11B6 uptake was performed on NMRI and BALB/c nude mice with subcutaneous LNCaP xenografts up to 14 d after injection. Tumor size was measured to assess response to radionuclide therapy. CLI correlated well with SPECT imaging and could be applied up to 14 d after injection of 20 MBq with the specific tracer used. Through integration of the CLI radiance as a function of time, a dose metric for the tumors could be formed that correlated exponentially with tumor volume reduction. CLI provided valuable intratherapeutic biokinetic measurements for treatment monitoring and could be used as a tool for subject-specific absorbed dose estimation. © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

  12. Biokinetic and dosimetric studies of 188Re-hyaluronic acid: a new radiopharmaceutical for treatment of hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Melendez-Alafort, Laura; Nadali, Anna; Zangoni, Elena; Banzato, Alessandra; Rondina, Maria; Rosato, Antonio; Mazzi, Ulderico

    2009-01-01

    Hepatocellular carcinoma (HCC) is the most common primary liver cancer and has very limited therapeutic options. Recently, it has been found that hyaluronic acid (HA) shows selective binding to CD44 receptors expressed in most cancer histotypes. Since the trend in cancer treatment is the use of targeted radionuclide therapy, the aim of this research was to label HA with rhenium-188 and to evaluate its potential use as a hepatocarcinoma therapeutic radiopharmaceutical. Methods: 188 Re-HA was prepared by a direct labelling method to produce a ReO(O-COO) 2 -type coordination complex. 188 Re-HA protein binding and its stability in saline, phosphate buffer, human serum and cysteine solutions were determined. Biokinetic and dosimetric data were estimated in healthy mice (n=60) using the Medical Internal Radiation Dose methodology and mouse model beta-absorbed fractions. To evaluate liver toxicity, alanine aminotranferase (AST) and aspartate aminotranferase (ALT) levels in mice were assessed and the liver maximum tolerated dose (MTD) of 188 Re-HA was determined. Results: A stable complex of 188 Re-HA was obtained with high radiochemical purity (>90%) and low serum protein binding (2%). Biokinetic studies showed a rapid blood clearance (T 1/2 α=21 min). Four hours after administration, 188 Re-HA was almost totally removed from the blood by the liver due to the selective uptake via HA-specific receptors (73.47±5.11% of the injected dose). The liver MTD in mice was ∼40 Gy after 7.4 MBq of 188 Re-HA injection. Conclusions: 188 Re-HA complex showed good stability, pharmacokinetic and dosimetric characteristics that confirm its potential as a new agent for HCC radiation therapy.

  13. Biokinetic and dosimetric studies of {sup 188}Re-hyaluronic acid: a new radiopharmaceutical for treatment of hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Melendez-Alafort, Laura [Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Padova, 35131 Padua (Italy)], E-mail: laura.melendez@unipd.it; Nadali, Anna; Zangoni, Elena [Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Padova, 35131 Padua (Italy); Banzato, Alessandra; Rondina, Maria [Dipartimento di Scienze Oncologiche e Chirurgiche, Universita degli Studi di Padova, Padua (Italy); Rosato, Antonio [Dipartimento di Scienze Oncologiche e Chirurgiche, Universita degli Studi di Padova, Padua (Italy); Istituto Oncologico Veneto, IOV, Padova, Padua (Italy); Mazzi, Ulderico [Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Padova, 35131 Padua (Italy)

    2009-08-15

    Hepatocellular carcinoma (HCC) is the most common primary liver cancer and has very limited therapeutic options. Recently, it has been found that hyaluronic acid (HA) shows selective binding to CD44 receptors expressed in most cancer histotypes. Since the trend in cancer treatment is the use of targeted radionuclide therapy, the aim of this research was to label HA with rhenium-188 and to evaluate its potential use as a hepatocarcinoma therapeutic radiopharmaceutical. Methods: {sup 188}Re-HA was prepared by a direct labelling method to produce a ReO(O-COO){sub 2}-type coordination complex. {sup 188}Re-HA protein binding and its stability in saline, phosphate buffer, human serum and cysteine solutions were determined. Biokinetic and dosimetric data were estimated in healthy mice (n=60) using the Medical Internal Radiation Dose methodology and mouse model beta-absorbed fractions. To evaluate liver toxicity, alanine aminotranferase (AST) and aspartate aminotranferase (ALT) levels in mice were assessed and the liver maximum tolerated dose (MTD) of {sup 188}Re-HA was determined. Results: A stable complex of {sup 188}Re-HA was obtained with high radiochemical purity (>90%) and low serum protein binding (2%). Biokinetic studies showed a rapid blood clearance (T{sub 1/2}{alpha}=21 min). Four hours after administration, {sup 188}Re-HA was almost totally removed from the blood by the liver due to the selective uptake via HA-specific receptors (73.47{+-}5.11% of the injected dose). The liver MTD in mice was {approx}40 Gy after 7.4 MBq of {sup 188}Re-HA injection. Conclusions: {sup 188}Re-HA complex showed good stability, pharmacokinetic and dosimetric characteristics that confirm its potential as a new agent for HCC radiation therapy.

  14. Biokinetics and dosimetry in patients of 99mTc-EDDA/HYNIC-Tyr3-octreotide prepared from lyophilized kits

    International Nuclear Information System (INIS)

    Gonzalez-Vazquez, Armando; Ferro-Flores, Guillermina; Arteaga de Murphy, Consuelo; Gutierrez-Garcia, Zohar

    2006-01-01

    99m Tc-EDDA/HYNIC-Tyr 3 -octreotide ( 99m Tc-HYNIC-TOC) has shown high in vitro and in vivo stability, rapid background clearance and rapid detection of somatostatin receptor-positive tumors. The aim of this study was to establish a biokinetic model for 99m Tc-HYNIC-TOC prepared from lyophilized kits, and to evaluate its dosimetry as a tumor imaging agent in patients with histologically confirmed neuroendocrine tumors. Whole-body images from eight patients were acquired at 5, 60, 90, 180 min and 24 h after 99m Tc-HYNIC-TOC administration obtained from instant freeze-dried kit formulations with radiochemical purities >95%. Regions of interest (ROIs) were drawn around source organs on each time frame. The same set of ROIs was used for all eight scans and the count per minute (cpm) of each ROI was converted to activity using the conjugate view counting method. The image sequence was used to extrapolate 99m Tc-HYNIC-TOC time-activity curves in each organ, to adjust a biokinetic model using the SAAM software, and to calculate the total number of disintegrations (N) that occurred in the source regions. N data were the input for the OLINDA/EXM code to calculate internal radiation dose estimates. Images showed an average tumor/blood (heart) ratio of 4.3±0.7 in receptor-positive tumors at 1 h. The mean radiation absorbed dose calculated for a study using 740 MBq was 24, 21.5, 5.5 and 1.0 mSv for spleen, kidneys, liver and bone marrow respectively and the effective dose was 4.4 mSv

  15. Dosimetric evaluation in organs of the Tc99m, I123 bio-kinetics to estimate dose in thyroid children 1 and 5 years

    International Nuclear Information System (INIS)

    Vasquez, A. M.; Quispe, R.; Vasquez, D. J.; Rocha, M. D.; Morales, N. R.; Marin, R. K.; Zelada, A. L.

    2012-10-01

    Using the formalism MIRD and the representation of Cristy-Eckerman for the thyroid in children of 1 and 5 years, is demonstrated that the dosimetric contribution of the organs of I 123 (iodure) bio-kinetics is not significant in the dose estimate. The total dose absorbed by the gland is its auto dose. The dosimetric contribution of the organs source of the Tc 99m (pertechnetate) bio-kinetics in the gland is significant in the dose estimate like to be ignored. The reported results for the iodure are not significantly different to the found for the Marinelli scheme (auto-dose) for thyroid represented by a sphere of 1,78 and 3,45 grams. (Author)

  16. Influence of zinc on the biokinetics of Zn-65 and hepatic trace elements of ethanol treated rats

    International Nuclear Information System (INIS)

    Dhawan, D.K.; Pathak, A.; Pathak, R.; Mahmood, A.

    2002-01-01

    Influence of zinc on the biokinetics of 65 Zn and hepatic trace elements of ethanol treated rats. The effect of zinc on the biokinetics of 65 Zn in liver and whole body and its relation to the hepatic levels of different elements was evaluated in male wistar rats under alcoholic conditions. The rats were segregated into four treatment groups viz., normal control, ethanol treated, zinc treated and combined zinc+ethanol treated. Animals were fed 3ml of 30% ethanol orally daily and zinc in the form of zinc sulfate (ZnSo 4 7H 2 O) was administrated to rats at a dose level of 227mg/L mixed in their drinking water for a total duration of 2 months. Whole body counting studies indicated that the Tb 1 i.e., the faster elimination of the radiotracer. On the contrary, Tb 2 i.e., the slower component was increased significantly following ethanol treatment. Percent uptake values of 65 Zn were found to be increased in liver, intestine, muscle and kidney and decreased in bone under alcoholic conditions. A significant elevation was noticed in in vitro uptake 65 Zn in ethanol treated animals. In the above said conditions, the values were reverted back to within normal limits upon zinc supplementation to these ethanol intoxicated animals, except in the case of in vitro 65 Zn uptake in liver where the uptake was further increased upon combined treatment. A significant decrease in zinc contents was noticed in ethanol treated rats, which however were raised to normal levels upon zinc supplementation. Copper levels, on the other hand, were found to be significantly enhanced in both ethanol fed and combined ethanol+zinc supplemented animals. Calcium levels were found to e significantly decreased in both ethanol and zinc treated rats, which however were further reduced upon zinc supplementation to ethanol fed rats. However, no significant change was observed in the concentrations of sodium and potassium in any of the treatment groups. Therefore, zinc appears to play a protective role by

  17. In vitro and in vivo interactions of selected nanoparticles with rodent serum proteins and their consequences in biokinetics

    Directory of Open Access Journals (Sweden)

    Wolfgang G. Kreyling

    2014-10-01

    Full Text Available When particles incorporated within a mammalian organism come into contact with body fluids they will bind to soluble proteins or those within cellular membranes forming what is called a protein corona. This binding process is very complex and highly dynamic due to the plethora of proteins with different affinities and fractions in different body fluids and the large variation of compounds and structures of the particle surface. Interestingly, in the case of nanoparticles (NP this protein corona is well suited to provide a guiding vehicle of translocation within body fluids and across membranes. This NP translocation may subsequently lead to accumulation in various organs and tissues and their respective cell types that are not expected to accumulate such tiny foreign bodies. Because of this unprecedented NP accumulation, potentially adverse biological responses in tissues and cells cannot be neglected a priori but require thorough investigations. Therefore, we studied the interactions and protein binding kinetics of blood serum proteins with a number of engineered NP as a function of their physicochemical properties. Here we show by in vitro incubation tests that the binding capacity of different engineered NP (polystyrene, elemental carbon for selected serum proteins depends strongly on the NP size and the properties of engineered surface modifications. In the following attempt, we studied systematically the effect of the size (5, 15, 80 nm of gold spheres (AuNP, surface-modified with the same ionic ligand; as well as 5 nm AuNP with five different surface modifications on the binding to serum proteins by using proteomics analyses. We found that the binding of numerous serum proteins depended strongly on the physicochemical properties of the AuNP. These in vitro results helped us substantially in the interpretation of our numerous in vivo biokinetics studies performed in rodents using the same NP. These had shown that not only the

  18. An integrated methodology for assessing the impact of food matrix and gastrointestinal effects on the biokinetics and cellular toxicity of ingested engineered nanomaterials.

    Science.gov (United States)

    DeLoid, Glen M; Wang, Yanli; Kapronezai, Klara; Lorente, Laura Rubio; Zhang, Roujie; Pyrgiotakis, Georgios; Konduru, Nagarjun V; Ericsson, Maria; White, Jason C; De La Torre-Roche, Roberto; Xiao, Hang; McClements, David Julian; Demokritou, Philip

    2017-10-13

    Engineered nanomaterials (ENMs) are increasingly added to foods to improve their quality, sensory appeal, safety and shelf-life. Human exposure to these ingested ENMs (iENMS) is inevitable, yet little is known of their hazards. To assess potential hazards, efficient in vitro methodologies are needed to evaluate particle biokinetics and toxicity. These methodologies must account for interactions and transformations of iENMs in foods (food matrix effect) and in the gastrointestinal tract (GIT) that are likely to determine nano-biointeractions. Here we report the development and application of an integrated methodology consisting of three interconnected stages: 1) assessment of iENM-food interactions (food matrix effect) using model foods; 2) assessment of gastrointestinal transformations of the nano-enabled model foods using a three-stage GIT simulator; 3) assessment of iENMs biokinetics and cellular toxicity after exposure to simulated GIT conditions using a triculture cell model. As a case study, a model food (corn oil-in-water emulsion) was infused with Fe 2 O 3 (Iron(III) oxide or ferric oxide) ENMs and processed using this three-stage integrated platform to study the impact of food matrix and GIT effects on nanoparticle biokinetics and cytotoxicity . A corn oil in phosphate buffer emulsion was prepared using a high speed blender and high pressure homogenizer. Iron oxide ENM was dispersed in water by sonication and combined with the food model. The resulting nano-enabled food was passed through a three stage (mouth, stomach and small intestine) GIT simulator. Size distributions of nano-enabled food model and digestae at each stage were analyzed by DLS and laser diffraction. TEM and confocal imaging were used to assess morphology of digestae at each phase. Dissolution of Fe2O3 ENM along the GIT was assessed by ICP-MS analysis of supernatants and pellets following centrifugation of digestae. An in vitro transwell triculture epithelial model was used to assess

  19. Calculating the interindividual geometric standard deviation for use in the integrated exposure uptake biokinetic model for lead in children.

    Science.gov (United States)

    Griffin, S; Marcus, A; Schulz, T; Walker, S

    1999-06-01

    The integrated exposure uptake biokinetic (IEUBK) model, recommended for use by the U.S. Environmental Protection Agency at residential Superfund sites to predict potential risks to children from lead exposure and to establish lead remediation levels, requires an interindividual geometric standard deviation (GSDi) as an essential input parameter. The GSDi quantifies the variability of blood lead concentrations for children exposed to similar environmental concentrations of lead. Estimates of potential risks are directly related to the GSDi, and therefore the GSDi directly impacts the scope of remediation at Superfund sites. Site-specific GSDi can be calculated for sites where blood lead and environmental lead have been measured. This paper uses data from blood and environmental lead studies conducted at the Bingham Creek and Sandy, Utah, Superfund sites to calculate GSDi using regression modeling, box modeling, and structural equation modeling. GSDis were calculated using various methods for treating values below the analytical method detection and quantitation limits. Treatment of nonquantifiable blood lead concentrations affected the GSDi more than the statistical method used to calculate the GSDi. For any given treatment, the different statistical methods produced similar GSDis. Because of the uncertainties associated with data in the blood lead studies, we recommend that a range of GSDis be used when analyzing site-specific risks associated with exposure to environmental lead instead of a single estimate. Because the different statistical methods produce similar GSDis, we recommend a simple procedure to calculate site-specific GSDi from a scientifically sound blood and environmental lead study.

  20. How well-mixed is well mixed? Hydrodynamic-biokinetic model integration in an aerated tank of a full-scale water resource recovery facility.

    Science.gov (United States)

    Rehman, Usman; Audenaert, Wim; Amerlinck, Youri; Maere, Thomas; Arnaldos, Marina; Nopens, Ingmar

    2017-10-01

    Current water resource recovery facility (WRRF) models only consider local concentration variations caused by inadequate mixing to a very limited extent, which often leads to a need for (rigorous) calibration. The main objective of this study is to visualize local impacts of mixing by developing an integrated hydrodynamic-biokinetic model for an aeration compartment of a full-scale WRRF. Such a model is able to predict local variations in concentrations and thus allows judging their importance at a process level. In order to achieve this, full-scale hydrodynamics have been simulated using computational fluid dynamics (CFD) through a detailed description of the gas and liquid phases and validated experimentally. In a second step, full ASM1 biokinetic model was integrated with the CFD model to account for the impact of mixing at the process level. The integrated model was subsequently used to evaluate effects of changing influent and aeration flows on process performance. Regions of poor mixing resulting in non-uniform substrate distributions were observed even in areas commonly assumed to be well-mixed. The concept of concentration distribution plots was introduced to quantify and clearly present spatial variations in local process concentrations. Moreover, the results of the CFD-biokinetic model were concisely compared with a conventional tanks-in-series (TIS) approach. It was found that TIS model needs calibration and a single parameter set does not suffice to describe the system under both dry and wet weather conditions. Finally, it was concluded that local mixing conditions have significant consequences in terms of optimal sensor location, control system design and process evaluation.

  1. Biokinetics of a transuranic ({sup 238}PU) and a rare earth element ({sup 152}Eu) in the lobster (Homarus gammarus): transfer mechanisms (accumulation and detoxification) in organs and at the cellular level; Biocinetiques d'un element transuranien, le {sup 238}PU, et d'une terre rare, le {sup 152}EU, chez le homard homarus gammarus (organes et niveau cellulaire) modalites des transferts (accumulation et detoxication)

    Energy Technology Data Exchange (ETDEWEB)

    Tocquet, N

    1995-07-01

    The work presented here is an experimental investigation of the biokinetics of transfer of a transuranic and a rare earth element ({sup 238}Pu and {sup 152}Eu) in the lobster Homarus gammarus. The study of {sup 238}Pu biokinetics forms part of a wider framework of research concerning the transfer of transuranic elements in marine species, while the study of {sup 152}Eu is carried out with a view to supporting the analogy between the behaviour of transuranics and rare earths in living organisms. Exactly the same experimental protocol, based on techniques from various disciplines (biology, biochemistry and metrology), was used to Investigate the biokinetics of transfer of these two radionuclides. The Individual lobsters were radiolabelled by means of one-shot or chronic ingestion of spiked meals. As the first approach, the kinetics and transfer mechanisms were studied In whole animal samples and in different organs distinct series of pathways through the different organs were identified in the case of both radionuclides, being mainly linked to digestive processes induced by the meal as well as the transport function of hemo-lymph in this way, the Important role of the digestive gland was picked out, with two of four cellular types displaying a successive involvement In the fixation and then the retention of the studied radionuclides. As a corroborative approach, the digestive gland was subjected to a more detailed investigation with the aim of describing the mechanisms of Incorporation and elucidating transfer processes at the cellular and molecular levels. {sup 238}Pu is preferentially partitioned into the cytosol, where it is associated with various constituents such as ferritin (iron-storing protein). {sup 152}Eu is more diffusely distributed in the hepato-pancreatic cells, while the lysosomes appear to play a more important role during transfer. The results obtained in this study, both on the macroscopic scale (i.e. the whole animal and different organs) as well

  2. Dosimetric contribution of the organs of the I123, I124 and I131 bio-kinetics in the dose estimate for euthyroid adults

    International Nuclear Information System (INIS)

    Vasquez, A. M.; Rojas, A. R.; Castillo, D. C.; Idrogo, C. J.; Flores, U. H.

    2011-10-01

    Using the formalism MIRD and the representation of Crysty-Eckerman for the thyroid adult, is demonstrated that the dosimetric contributions of source organs of the biokinetics of the radiopharmaceuticals I 123 , I 124 and I 131 (iodine) are not significant in the dose estimate. Therefore, the total absorbed dose by the gland is its auto-dose. Equally, the reported results do not present significant differences to the results found by the Marinelli scheme (auto-dose) for the thyroid represented by a sphere of 20 grams. (Author)

  3. Kit preparation and biokinetics in women of 99mTc-EDDA/HYNIC-E-[c(RGDfK)]2 for breast cancer imaging.

    Science.gov (United States)

    Ortiz-Arzate, Zareth; Santos-Cuevas, Clara L; Ocampo-García, Blanca E; Ferro-Flores, Guillermina; García-Becerra, Rocío; Estrada, Gisela; Gómez-Argumosa, Edgar; Izquierdo-Sánchez, Vanessa

    2014-04-01

    In breast cancer, α(ν)β(3) and/or α(ν)β(5) integrins are overexpressed in both endothelial and tumour cells. Radiolabelled peptides based on the Arg-Gly-Asp (RGD) sequence are radiopharmaceuticals with high affinity and selectivity for these integrins. The RGD-dimer peptide (E-[c(RGDfK)]2) radiolabelled with (99m)Tc has been reported as a radiopharmaceutical with a 10-fold higher affinity for the α(ν)β(3) integrin compared with the RGD-monomer. Ethylenediamine-N,N'-diacetic acid (EDDA) is a hydrophilic molecule that may favour renal excretion when used as coligand in the (99m)Tc labelling of hydrazinonicotinamide (HYNIC) peptides and can easily be formulated in a lyophilized kit. The aim of this study was to establish a biokinetic model for (99m)Tc-EDDA/HYNIC-E-[c(RGDfK)]2 prepared from lyophilized kits and evaluate its dosimetry as a tumour-imaging agent in seven healthy women and three breast cancer patients. (99m)Tc labelling was performed by adding sodium pertechnetate solution and 0.2 mol/l phosphate buffer (pH 7.0) to a lyophilized formulation containing E-[c(RGDfK)]2, EDDA, tricine, mannitol and stannous chloride. The radiochemical purity was evaluated using reverse-phase high-performance liquid chromatography and instant thin-layer chromatography on silica gel analyses. Stability studies in human serum were carried out using size-exclusion high-performance liquid chromatography. In-vitro cell uptake was tested using breast cancer cells (MCF7, T47D and MDA-MB-231) with blocked and nonblocked receptors. Biodistribution and tumour uptake were determined in MCF7 tumour-bearing nude mice with blocked and nonblocked receptors, and images were obtained using a micro-SPECT/PET/CT. Whole-body images from seven healthy women were acquired at 0.5, 1, 3, 6 and 24 h after (99m)Tc-EDDA/HYNIC-E-[c(RGDfK)]2 administration with radiochemical purities greater than 94%. Regions of interest were drawn around the source organs at each time frame. Each region of

  4. Biokinetics and dosimetry of 99m Tc-EDDA/HYNIC-[Lys3]-bombesin in humans: imaging of GRP receptors

    International Nuclear Information System (INIS)

    Santos C, C.L.; Ferro F, G.; Murphy, C.A de; Cardena, E.; Pichardo R, P.

    2007-01-01

    Full text: Bombesin (BN) receptor subtype 2 (GRP-r) is over-expressed on various human tumors including breast, prostate, small cell lung and pancreatic cancer. Recently we reported the 99- mTc-EDDA/HYNIC-[Lys 3 ]-Bombesin ( 99m Tc-HYNIC-BN) complex as a new radiopharmaceutical with high stability in human serum, specific cell GRP-receptor binding and rapid internalization. The aim of this study was to evaluate the 99m Tc-HYNIC-BN biokinetics and dosimetry in 5-healthy and 3-breast cancer women. Whole-body images were acquired at 20, 90, 180 min and 24 h after 99m Tc-HYNIC-BN administration. Regions of interest (ROIs) were drawn around source' organs on each time frame. The same set of ROIs was used for all 8 scans and the cpm of each ROI was converted to activity using the conjugate view counting method. The image sequence was used to extrapolate 99m Tc-HYNIC-BN time activity curves in each organ, to calculate the total number of disintegrations (N) that occurred in the source regions. N data were the input for the OLINDA/EXM code to calculate internal radiation dose estimates. Images showed a rapid radiopharmaceutical blood clearance with predominantly renal excretion and minimal hepatobiliary elimination. 99m Tc-HYNIC-BN exhibited high in vivo affinity for GRP-r over-expression successfully visualized in breast cancer lesions and well differentiated from GRP-r expression in lungs and airways with normal GRP-r density (ratio 3:1). The equivalent doses for a study using 370 MBq were 7.38±1.68, 0.59±0.08, 2.07±0.60, 0.58±0.1, 0.75±0.09 and 0.43±0.07 mSv for kidneys, liver, lungs, ovaries, pancreas and red marrow respectively. The effective dose was 1.64±0.25 mSv which is comparable with the doses known for most of the 99m Tc radiopharmaceutical studies in nuclear medicine. (Author)

  5. Biokinetics and dosimetry of {sup 111}In-DOTA-NOC-ATE compared with {sup 111}In-DTPA-octreotide

    Energy Technology Data Exchange (ETDEWEB)

    Boubaker, Ariane; Prior, John O.; Champendal, Melanie; Bischof Delaloye, Angelika [Lausanne University Hospital, CHUV, Department of Nuclear Medicine, Lausanne (Switzerland); Willi, Jean-Pierre [University Hospital of Geneva, Department of Nuclear Medicine, Geneva 14 (Switzerland); Kosinski, Marek; Baechler, Sebastien [Lausanne University Hospital, Institute of Radiation Physics, Lausanne (Switzerland); Maecke, Helmut R. [University Hospital of Freiburg, Department of Nuclear Medicine, Freiburg (Germany); Ginj, Mihaela [University Health Network, Joint Department of Medical Imaging, Toronto, ON (Canada); Buchegger, Franz [Lausanne University Hospital, CHUV, Department of Nuclear Medicine, Lausanne (Switzerland); University Hospital of Geneva, Department of Nuclear Medicine, Geneva 14 (Switzerland)

    2012-12-15

    The biokinetics and dosimetry of {sup 111}In-DOTA-NOC-ATE (NOCATE), a high-affinity ligand of SSTR-2 and SSTR-5, and {sup 111}In-DTPA-octreotide (Octreoscan trademark, OCTREO) were compared in the same patients. Seventeen patients (10 men, 7 women; mean age 60 years), referred for an OCTREO scan for imaging of a neuroendocrine tumour (15), thymoma (1) or medullary thyroid carcinoma (1), agreed to undergo a second study with NOCATE. Whole-body anterior-posterior scans were recorded 0.5 (100 % reference scan), 4, 24 and 48 h (17 patients) and 120 h (5 patients) after injection. In 16 patients the OCTREO scan (178 {+-} 15 MBq) was performed 16 {+-} 5 days before the NOCATE scan (108 {+-} 14 MBq) with identical timing; 1 patient had the NOCATE scan before the OCTREO scan. Blood samples were obtained from 14 patients 5 min to 48 h after injection. Activities expressed as percent of the initial (reference) activity in the whole body, lung, kidney, liver, spleen and blood were fitted to biexponential or single exponential functions. Dosimetry was performed using OLINDA/EXM. Initial whole-body, lung and kidney activities were similar, but retention of NOCATE was higher than that of OCTREO. Liver and spleen uptakes of NOCATE were higher from the start (p < 0.001) and remained so over time. Whole-body activity showed similar {alpha} and {beta} half-lives, but the {beta} fraction of NOCATE was double that of OCTREO. Blood T{sub 1/2}{beta} for NOCATE was longer (19 vs. 6 h). As a result, the effective dose of NOCATE (105 {mu}Sv/MBq) exceeded that of OCTREO (52 {mu}Sv/MBq), and the latter result was similar to the ICRP 106 value of 54 {mu}Sv/MBq. Differential activity measurement in blood cells and plasma showed an average of <5 % of NOCATE and OCTREO attached to globular blood components. NOCATE showed a slower clearance from normal tissues and its effective dose was roughly double that of OCTREO. (orig.)

  6. Dosimetric contribution of organs of biokinetics of {sup 99m}Tc and {sup 123}I to estimate radiation doses in thyroids of children of 1 and 5 years; Contribucion dosimetrica de organos de la biocinetica del {sup 99m}Tc y {sup 123}I para estimar dosis en tiroides de ninos de 1 y 5 anos

    Energy Technology Data Exchange (ETDEWEB)

    Vasquez, M.V.; Castillo, C.E.; Abanto, D.M.; Rocha, D.; Garcia, W.H.; Marin, K., E-mail: marvva@hotmail.com [Universidad Nacional de Trujillo (UNT), Trujillo (Peru); Quispe, R. [Centro de Ciencias Aplicadas y Desarrollo Tecnologico, UNAM, Mexico (Mexico)

    2015-07-01

    The absorbed doses by thyroids during uptake studies through biokinetics of radiopharmaceuticals containing {sup 123}I (iodine) or {sup 99m}Tc (pertechnetate) are estimated. Using the MIRD scheme and the representation of Cristy-Eckerman for thyroids in children of 1 and 5 years, the objective of the study was to determine whether the dosimetric biokinetic contributions of the organs of {sup 123}I (iodide) and {sup 99m}Tc (pertechnetate) biokinetic are significant in the estimated of the absorbed dose for thyroid uptake studies.

  7. Synthesis, labeling with 99mTc and biokinetics of brains scintigraphy diaminodithiol perfusion radiopharmaceuticals

    International Nuclear Information System (INIS)

    Goncalves, Marcos Moises

    1999-01-01

    The recent tomography status using radiopharmaceuticals have been contributing greatly with the 'age of certainty' in the diagnosis examination of syndromes, pathologies and clinical signs, because they can evidence some phenomena occurring in a molecular manner. The purpose of this work have had the development of new diaminodithiol (DADT) perfusion radiopharmaceuticals to be used in brain diagnosis using S.P.E.T. (Single Photon Emission Tomography). Initially, the rational planning had been performed with the new DADT molecular structures as radiopharmaceutical candidates. Using of Q.S.A.R. (Quantitative Structure Activity Relationship) techniques, the molecular descriptors such as partition coefficient and effective polarizability, have been studied in order to increase the blood brain barrier transport and the brain uptake respectively. Applying the Q.S.P.R. (Quantitative Structure Property Relationship) concepts to perform drug latentiation, based on bio-labile functional groups, the congener DADT derivative has been transformed into a pro-drug that works as a DADT moiety carrier, allowing the increasing of brain radiopharmaceutical uptake. Later on, synthetic routes and chemical purifications have been developed allowing the creation of the proposed chemical structure. Each new DADT derivative has been synthesized and analyzed in terms of elemental analysis, infrared and NMR spectra, in order to confirm its proposed chemical structure. Then, the new derivative has been labeled with 99m Tc, radiochemically purified, intravenously injected in Swiss mice, allowing its biodistribution to evidence its brain transport and uptake. The rational planning studies have been re-evaluated after each biodistribution had been performed, to see what kind of molecular descriptor was responsible for causing a stronger optimization in the brain perfusion characteristics and then, new DADT derivatives have been prepared. Three new DADT derivatives have been obtained by using

  8. Blood doses and remnant biokinetics after thyroid ablation therapy of differentiated thyroid cancer: withdrawal vs. rh TSH

    International Nuclear Information System (INIS)

    Lassmann, Michael; Haenscheid, Heribert; Luster, Markus; Reiners, Christoph; Ablation, Trial Study Group

    2005-01-01

    Full text: An international randomized multicenter trial (9 sites; North America: 5, Europe: 4) was carried out investigating the effectiveness of ablation therapy with 3.7 GBq 131 I in differentiated thyroid cancer. We present the results of the trial dosimetry assessments. 63 patients were randomized after thyroidectomy to either hypothyroidism (THW) or euthyroidism in combination with rh TSH (0.9 mg q d x 2, Thyrogen). The biokinetics and residence times (RT) of the remnants were assessed from 3 neck scans starting 48 h after administration. The blood doses (a surrogate for the bone marrow dose) were calculated from activity concentrations in blood samples and 131 I whole body retention measurements between 2 and 168 h after 131 I administration. The overall dosimetry results were calculated centrally (Wuerzberg) in an externally audited standardized data evaluation procedure. The patient ablation rate was 100%. The 48 h 131 I uptake was lower in the remnant tissue of the rh TSH group: 0.5 ± 0.7%; THW group: 0.9 ±1.0% (p=0.1), the effective half life showed smaller values for the THW group (48.0 ± 52.6 h vs. 67.6 ± 48.9 h, p=0.0116). The mean RT in the remnant tissue was shorter in the rh TSH group: 0.9 ± 1.3 h; THW group: 1.4 ± 1.5 h (p=0.1). A greater decrease in the mean percentage of administered activity in the blood at 48 h, and a lower mean residence time was seen in the rh TSH group: 0.8%, RT: 2.3 ± 0.7 h; THW group: 1.8% (p=0.0011), RT: 3.5 ± 1.63 h (p=0.0004). The mean specific blood dose was significantly lower (p<0.0001) in the rh TSH group (0.072 ± 0.017 mGy/MBq, blood vessel radius (VR):0.2 mm; 0.104 ± 0.025 mGy/MBq, VR: 5 mm) than in the Hypothyroid group (0.106 ± 0.037 mGy/MBq, VR: 0.2 mm; 0.158 ± 0.059 mGy/MBq, VR: 5 mm). Conclusion: Although the remnant RT tended to be lower in the rh TSH group the ablation rates in the 2 study arms were comparable. The radiation dose to the blood was significantly lower in the rh TSH group. This

  9. Biokinetics and dosimetry in patients of 99mTc-HYNIC-Lys3-Bombesin: images of GRP receptors

    International Nuclear Information System (INIS)

    Santos C, C. L.

    2007-01-01

    The bombesin (BN) receptor subtype 2 (GRP-r) is expressed in several normal human tissues and is over-expressed in various human tumors including breast, prostate, small cell lung and pancreatic cancer. Recently [ 99m Tc]EDDA/HYNIC-Lys 3 -bombesin ( 99m Tc-HYNIC-BN) was reported as a radiopharmaceutical with high stability in human serum, specific cell GRP-r binding and rapid cell internalization. The aim of this study was to evaluate the feasibility of using 99m Tc-HYNIC-BN to image GRP-r and to assess the radiopharmaceutical biokinetics and dosimetry in 4 breast cancer patients and in 7 healthy women. Methods: Whole-body images were acquired at 20, 90, 180 min and 24 h after 99m Tc-HYNIC-BN administration. Regions of interest (ROIs) were drawn around source organs on each time frame. The same set of ROIs was used for all 11 scans and the cpm of each ROI was converted to activity using the conjugate view counting method. The image sequence was used to extrapolate 99m Tc-HYNIC-BN time-activity curves in each organ in order to calculate the total number of disintegrations (N) that occurred in the source regions, according with MIRD methodology. N data were the input for the OLINDA/EXM code to calculate internal radiation dose estimates. Results: Images showed a rapid radiopharmaceutical blood clearance with renal excretion as predominant route. 99m Tc-HYNIC-BN exhibited high in vivo affinity for GRP-r over-expression successfully visualized in cancer mammary glands and well differentiated from the ubiquitous GRP-r expression in normal breast, lungs and airways. There was no statistically significant difference (p > 0.05) in the radiation absorbed doses between cancer patients and healthy women. The average equivalent doses (n=11) for a study using 740 MBq were 24.8 +- 8.8 mSv (kidneys), 7.3 +- 1.8 mSv (lungs), 6.5 +- 4.0 mSv (breast) 2.0 +- 0.3 mSv (pancreas), 1.6 +- 0.3 mSv (liver), 1.2 +- 0.2 mSv (ovaries) and 1.0 +- 0.2 mSv (red marrow). The mean effective dose

  10. Performance analysis of numeric solutions applied to biokinetics of radionuclides; Analise de desempenho de solucoes numericas aplicadas a biocinetica de radionuclideos

    Energy Technology Data Exchange (ETDEWEB)

    Mingatos, Danielle dos Santos; Bevilacqua, Joyce da Silva, E-mail: dani@ime.usp.br, E-mail: joyce@ime.usp.br [Universidade de Sao Paulo (IME/USP), SP (Brazil). Instituto de Matematica e Estatistica; Todo, Alberto Saburo; Rodrigues Junior, Orlando, E-mail: astodo@ipen.br, E-mail: rodrijr@ipen.br [Instituto de Pesquisas Energeticas Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    Biokinetics models for radionuclides applied to dosimetry problems are constantly reviewed by ICRP. The radionuclide trajectory could be represented by compartmental models, assuming constant transfer rates between compartments. A better understanding of physiological or biochemical phenomena, improve the comprehension of radionuclide behavior in the human body and, in general, more complex compartmental models are proposed, increasing the difficulty of obtaining the analytical solution for the system of first order differential equations. Even with constant transfer rates numerical solutions must be carefully implemented because of almost singular characteristic of the matrix of coefficients. In this work we compare numerical methods with different strategies for ICRP-78 models for Thorium-228 and Uranium-234. The impact of uncertainty in the parameters of the equations is also estimated for local and global truncation errors. (author)

  11. Biokinetics and radiation dosimetry of {sup 14}C-labelled triolein, urea, glycocholic acid and xylose in man. Studies related to nuclear medicine 'breath tests' using accelerator mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Gunnarsson, Mikael

    2002-08-01

    {sup 14}C-labelled substances have been used in biomedical research and clinical medicine for over 50 years. Physicians and scientists however, often hesitate to use these substances in patients and volunteers because the radiation dosimetry is unclear. In this work detailed long-term biokinetic and dosimetric estimation have been carried out for four clinically used {sup 14}C-breath tests: {sup 14}C-triolein (examination of fat malabsorption), urea (detection of Helicobacter pylori infection in the stomach), glycocholic acid and xylose (examination of bacterial overgrowth in the small intestine) by using the highly sensitive accelerator mass-spectrometry (AMS) technique. The AMS technique has been used to measure low {sup 14}C concentrations in small samples of exhaled air, urine, faeces and tissue samples and has improved the base for the estimation of the absorbed dose to various organs and tissues and the effective dose to man. The high sensitivity of the AMS system has also made it possible to perform {sup 14}C breath tests on patient groups which were earlier subject for restriction (e.g. small children). In summary, our results show that for adult patients - and in the case of {sup 14}C-urea breath test also for children down to 3 years of age - the dose contributions are comparatively low, both described as organ doses and as effective doses. For adults, the latter is: {sup 14}C-glycocholic acid - 0.4 mSv/MBq, {sup 14}C-triolein - 0.3 mSv/MBq, {sup 14}C-xylose - 0.1 mSv/MBq and {sup 14}C-urea - 0.04 mSv/MBq. Thus, from a radiation protection point of view there is no reason for restrictions in using any of the {sup 14}C-labelled radiopharmaceutical included in this work in the activities normally used (0.07-0.2 MBq for a 70 kg patient)

  12. Biokinetics and dosimetry in patients of {sup 99m}Tc-EDDA/HYNIC-Tyr{sup 3}-octreotide prepared from lyophilized kits

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez-Vazquez, Armando [Departamento de Medicina Nuclear, Hospital Militar (Mexico); Facultad de Medicina, Universidad Autonoma del Estado de Mexico (Mexico); Ferro-Flores, Guillermina [Departamento de Materiales Radiactivos, Gerencia de Aplicaciones Nucleares en la Salud, Instituto Nacional de Investigaciones Nucleares, Km. 36.5 Carretera Mexico-Toluca, Ocoyoacac, Estado de Mexico, C.P. 52045 (Mexico)]. E-mail: gff@nuclear.inin.mx; Arteaga de Murphy, Consuelo [Departamento de Medicina Nuclear, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (Mexico); Gutierrez-Garcia, Zohar [Departamento de Medicina Nuclear, Hospital Militar (Mexico)

    2006-07-15

    {sup 99m}Tc-EDDA/HYNIC-Tyr{sup 3}-octreotide ({sup 99m}Tc-HYNIC-TOC) has shown high in vitro and in vivo stability, rapid background clearance and rapid detection of somatostatin receptor-positive tumors. The aim of this study was to establish a biokinetic model for {sup 99m}Tc-HYNIC-TOC prepared from lyophilized kits, and to evaluate its dosimetry as a tumor imaging agent in patients with histologically confirmed neuroendocrine tumors. Whole-body images from eight patients were acquired at 5, 60, 90, 180 min and 24 h after {sup 99m}Tc-HYNIC-TOC administration obtained from instant freeze-dried kit formulations with radiochemical purities >95%. Regions of interest (ROIs) were drawn around source organs on each time frame. The same set of ROIs was used for all eight scans and the count per minute (cpm) of each ROI was converted to activity using the conjugate view counting method. The image sequence was used to extrapolate {sup 99m}Tc-HYNIC-TOC time-activity curves in each organ, to adjust a biokinetic model using the SAAM software, and to calculate the total number of disintegrations (N) that occurred in the source regions. N data were the input for the OLINDA/EXM code to calculate internal radiation dose estimates. Images showed an average tumor/blood (heart) ratio of 4.3{+-}0.7 in receptor-positive tumors at 1 h. The mean radiation absorbed dose calculated for a study using 740 MBq was 24, 21.5, 5.5 and 1.0 mSv for spleen, kidneys, liver and bone marrow respectively and the effective dose was 4.4 mSv.

  13. Estimation of parameters biokinetics from the resolution of a model compartment for I-131. Application to a patient with thyroid carcinoma hemodialysis; Estimacion de parametros bioceniticos a partir de la resolucion de un modelo compartimental para I-131. Aplicacion a un paciente hemodializado con carcinoma de torioides

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, R.; Jimenez Feltstrom, D.; Luis dimon, F. J.; Sanchez Carmona, G.; Herrador Cordoba, M.

    2013-07-01

    This work aims to define a biokinetic model for the I-131, and solve it for different conditions of the patient or person affected (normal, with cancer of the thyroid or hyperthyroid). Solve the model in the case of a patient treated with I-131 for ablation of thyroid remnants with undergoing renal insufficiency and hemodialysis . Get the parameters Biokinetic this model for different situations. (Author)

  14. Estimating 131I biokinetics and radiation doses to the red marrow and whole body in thyroid cancer patients: probe detection versus image quantification

    Directory of Open Access Journals (Sweden)

    José Willegaignon

    2016-06-01

    Full Text Available Abstract Objective: To compare the probe detection method with the image quantification method when estimating 131I biokinetics and radiation doses to the red marrow and whole body in the treatment of thyroid cancer patients. Materials and Methods: Fourteen patients with metastatic thyroid cancer, without metastatic bone involvement, were submitted to therapy planning in order to tailor the therapeutic amount of 131I to each individual. Whole-body scans and probe measurements were performed at 4, 24, 48, 72, and 96 h after 131I administration in order to estimate the effective half-life (Teff and residence time of 131I in the body. Results: The mean values for Teff and residence time, respectively, were 19 ± 9 h and 28 ± 12 h for probe detection, compared with 20 ± 13 h and 29 ± 18 h for image quantification. The average dose to the red marrow and whole body, respectively, was 0.061 ± 0.041 mGy/MBq and 0.073 ± 0.040 mGy/MBq for probe detection, compared with 0.066 ± 0.055 mGy/MBq and 0.078 ± 0.056 mGy/MBq for image quantification. Statistical analysis proved that there were no significant differences between the two methods for estimating the Teff (p = 0.801, residence time (p = 0.801, dose to the red marrow (p = 0.708, and dose to the whole body (p = 0.811, even when we considered an optimized approach for calculating doses only at 4 h and 96 h after 131I administration (p > 0.914. Conclusion: There is full agreement as to the feasibility of using probe detection and image quantification when estimating 131I biokinetics and red-marrow/whole-body doses. However, because the probe detection method is inefficacious in identifying tumor sites and critical organs during radionuclide therapy and therefore liable to skew adjustment of the amount of 131I to be administered to patients under such therapy, it should be used with caution.

  15. Prediction of iodine-131 biokinetics and radiation doses from therapy on the basis of tracer studies: an important question for therapy planning in nuclear medicine.

    Science.gov (United States)

    Willegaignon, José; Pelissoni, Rogério A; Lima, Beatriz C G D; Sapienza, Marcelo T; Coura-Filho, George B; Buchpiguel, Carlos A

    2016-05-01

    This study aimed to present a comparison of iodine-131 (I) biokinetics and radiation doses to red-marrow (rm) and whole-body (wb), following the administration of tracer and therapeutic activities, as a means of confirming whether I clearance and radiation doses for therapy procedures can be predicted by tracer activities. Eleven differentiated thyroid cancer patients were followed after receiving tracer and therapeutic I activity. Whole-body I clearance was estimated using radiation detectors and OLINDA/EXM software was used to calculate radiation doses to rm and wb. Tracer I activity of 86 (±14) MBq and therapeutic activity of 8.04 (±1.18) GBq were administered to patients, thereby producing an average wb I effective half-time and residence time of, respectively, 13.51 (±4.05) and 23.13 (±5.98) h for tracer activities and 13.32 (±3.38) and 19.63 (±4.77) h for therapy. Radiation doses to rm and wb were, respectively, 0.0467 (±0.0208) and 0.0589 (±0.0207) mGy/MBq in tracer studies and 0.0396 (±0.0169) and 0.0500 (±0.0163) mGy/MBq in therapy. Although the differences were not considered statistically significant between averages, those between the values of effective half-times (P=0.906), residence times (P=0.145), and radiation doses to rm (P=0.393) and to wb (P=0.272), from tracer and therapy procedures, large differences of up to 80% in wb I clearance, and up to 50% in radiation doses were observed when patients were analyzed individually, thus impacting on the total amount of I activity calculated to be safe for application in individual therapy. I biokinetics and radiation doses to rm and wb in therapy procedures are well predicted by diagnostic activities when average values of a group of patients are compared. Nonetheless, when patients are analyzed individually, significant differences may be encountered, thus implying that nuclear medicine therapy-planning requires due consideration of changes in individual patient-body status from

  16. Estimating {sup 131}I biokinetics and radiation doses to the red marrow and whole body in thyroid cancer patients: probe detection versus image quantification

    Energy Technology Data Exchange (ETDEWEB)

    Willegaignon, Jose; Pelissoni, Rogerio Alexandre; Lima, Beatriz Christine de Godoy Diniz; Coura-Filho, George Barberio; Queiroz, Marcelo Araujo, E-mail: j.willegaignon@gmail.com [Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira (ICESP), Sao Paulo, SP (Brazil); Sapienza, Marcelo Tatit; Buchpiguel, Carlos Alberto [Universidade de Sao Paulo (FM/USP), Sao Paulo, SP (Brazil). Faculdade de Medicina. Departamento de Radiologia

    2016-05-15

    Objective: to compare the probe detection method with the image quantification method when estimating {sup 131}I biokinetics and radiation doses to the red marrow and whole body in the treatment of thyroid cancer patients. Materials and methods: fourteen patients with metastatic thyroid cancer, without metastatic bone involvement, were submitted to therapy planning in order to tailor the therapeutic amount of {sup 131}I to each individual. Whole-body scans and probe measurements were performed at 4, 24, 48, 72, and 96 h after {sup 131}I administration in order to estimate the effective half-life (T{sub eff}) and residence time of {sup 131}I in the body. Results: the mean values for T{sub eff} and residence time, respectively, were 19 ± 9 h and 28 ± 12 h for probe detection, compared with 20 ± 13 h and 29 ± 18 h for image quantification. The average dose to the red marrow and whole body, respectively, was 0.061 ± 0.041 mGy/MBq and 0.073 ± 0.040 mGy/MBq for probe detection, compared with 0.066 ± 0.055 mGy/MBq and 0.078 ± 0.056 mGy/MBq for image quantification. Statistical analysis proved that there were no significant differences between the two methods for estimating the T{sub eff} (p = 0.801), residence time (p = 0.801), dose to the red marrow (p = 0.708), and dose to the whole body (p = 0.811), even when we considered an optimized approach for calculating doses only at 4 h and 96 h after {sup 131}I administration (p > 0.914). Conclusion: there is full agreement as to the feasibility of using probe detection and image quantification when estimating {sup 131}I biokinetics and red-marrow/whole-body doses. However, because the probe detection method is ineffective in identifying tumor sites and critical organs during radionuclide therapy and therefore liable to skew adjustment of the amount of {sup 131}I to be administered to patients under such therapy, it should be used with caution. (author)

  17. Biokinetics and dosimetry of a hybrid formulation of 9mTc-BN and 99mTc-RGD2 starting from optic images in a murine model

    International Nuclear Information System (INIS)

    Cornejo A, L. G.

    2015-01-01

    This work has the purpose of evaluate the biokinetics and absorbed dose of radiation of hybrid formulation 99m Tc-BN / 99m Tc-RGD 2 in a murine model by optical imaging techniques using the multimodal preclinical in vivo image system Xtreme. The used method were the 99m Tc-BN, 99m Tc-RGD 2 and 99m Tc-BN/ 99m Tc-RGD 2 formulas, with specific recognition for GRPr and the integrin s α(v)β(3) and α(v)β(5) respectively, was injected in the vein tail of three nude mousses with induce breast cancer tumors (cell line T-47-D), by the preclinical multimodal imaging system Xtreme (Bruker), optical images in different times was acquired (5, 10, 20 min, 2 and 24 h), using Images Processing Toolbox of MATLAB these images was transform from RGB format to gray scales and sectioned in five independent images corresponding to heart, kidneys, bladder and tumor areas. The intensity of each images was computed in counts per pixel, then those intensities was corrected for background, attenuation and scattering, using different factors for each phenomena previously calculated. Finally the activity values quantified vs time was fitted into a biokinetic model to obtain the disintegrations number and cumulate activities in each organ. With these data the radiation absorbed dose were calculated using MIRD methodology. Results: The number of disintegration and absorbed dose calculated in MBq h/MBq and mGy/MBq, of injected mouse with the 99m Tc-BN/ 99m Tc-RGD 2 formulation, was: 0.035 ± 0.65 E-02, 0.25 x 10 -5 ± 0.46 E-07; 0.393 ± 0.51 E-1, 2.85 E-05 ± 3.7 E-06; 0.306 ± 0.21 E-01, 2.11 E-05 ± 1.45 E-06 and 0.151 ± 0.19 E-01, 1.09 E-05 ± 1.42 E-06 , in heart, kidneys, bladder and tumor, respectively. The number of disintegration obtained in kidneys is comparable to those reported for Trinidad B. 2014 Conclusions: Our results demonstrated that using optical images and a code for image analyses development in MATLAB, could achieve comparable quantitative results as the conventional

  18. Energy use and carbon footprints differ dramatically for diverse wastewater-derived carbonaceous substrates: An integrated exploration of biokinetics and life-cycle assessment.

    Science.gov (United States)

    Li, Yanbo; Wang, Xu; Butler, David; Liu, Junxin; Qu, Jiuhui

    2017-03-21

    Energy neutrality and reduction of carbon emissions are significant challenges to the enhanced sustainability of wastewater treatment plants (WWTPs). Harvesting energy from wastewater carbonaceous substrates can offset energy demands and enable net power generation; yet, there is limited research about how carbonaceous substrates influence energy and carbon implications of WWTPs with integrated energy recovery at systems-level. Consequently, this research uses biokinetics modelling and life cycle assessment philology to explore this notion, by tracing and assessing the quantitative flows of energy embodied or captured, and by exploring the carbon footprint throughout an energy-intensive activated sludge process with integrated energy recovery facilities. The results indicate that energy use and carbon footprint per cubic meter of wastewater treated, varies markedly with the carbon substrate. Compared with systems driven with proteins, carbohydrates or other short-chain fatty acids, systems fed with acetic acid realized energy neutrality with maximal net gain of power from methane combustion (0.198 kWh) and incineration of residual biosolids (0.153 kWh); and also achieved a negative carbon footprint (72.6 g CO 2 ). The findings from this work help us to better understand and develop new technical schemes for improving the energy efficiency of WWTPs by repurposing the stream of carbon substrates across systems.

  19. Radiation fields, dosimetry, biokinetics and biophysical models for cancer induction by ionising radiation 1996 - 1999. Mid-term reports for the period 1996-1997

    International Nuclear Information System (INIS)

    Jacob, P.; Paretzke, H.G.; Roth, P.

    1998-01-01

    The main objectives of the first dosimetry project are the measurement of neutron and charged particle flux and energy spectra at altitudes in civil aviation, the determination of response characteristics for detectors, the investigation of calibration procedures, and the evaluation of exposures of aircrews. The overall objective of the second dosimetry project is to improve estimates of dose following the intake of radionuclides by adults and children. The work includes the development of biokinetic and dosimetric models, including models of the gastrointestinal tract, for the systemic behaviour of radionuclides, and for the developing embryo and foetus. Further subjects are target cell dosimetry for short-range particles and the development of computational tools for sensitivity and uncertainty analysis models. The third dosimetry project encompasses the study of different methods for retrospective dose assessments for individuals or groups of individuals accidentally exposed to increased levels of radiation. The methods investigated include electron paramagnetic resonance (EPR) of tooth enamel and chromosome painting (FISH) for lymphocytes in peripheral blood for individual retrospective dose assessments, luminescence techniques on materials in inhabited environment (ceramics, bricks) and model calculations using environmental data as input. (orig.)

  20. Radiation fields, dosimetry, biokinetics and biophysical models for cancer induction by ionising radiation 1996 - 1999. Mid-term reports for the period 1996-1997

    Energy Technology Data Exchange (ETDEWEB)

    Jacob, P.; Paretzke, H.G.; Roth, P. [GSF - Forschungszentrum fuer Umwelt und Gesundheit Neuherberg GmbH, Oberschleissheim (Germany). Inst. fuer Strahlenschutz; Michael, B.D. [Mount Vernon Hospital, Northwood (United Kingdom). Gray Lab.; O`Sullivan, D. [Dublin Inst. for Advanced Studies (Ireland)

    1998-12-31

    The main objectives of the first dosimetry project are the measurement of neutron and charged particle flux and energy spectra at altitudes in civil aviation, the determination of response characteristics for detectors, the investigation of calibration procedures, and the evaluation of exposures of aircrews. The overall objective of the second dosimetry project is to improve estimates of dose following the intake of radionuclides by adults and children. The work includes the development of biokinetic and dosimetric models, including models of the gastrointestinal tract, for the systemic behaviour of radionuclides, and for the developing embryo and foetus. Further subjects are target cell dosimetry for short-range particles and the development of computational tools for sensitivity and uncertainty analysis models. The third dosimetry project encompasses the study of different methods for retrospective dose assessments for individuals or groups of individuals accidentally exposed to increased levels of radiation. The methods investigated include electron paramagnetic resonance (EPR) of tooth enamel and chromosome painting (FISH) for lymphocytes in peripheral blood for individual retrospective dose assessments, luminescence techniques on materials in inhabited environment (ceramics, bricks) and model calculations using environmental data as input. (orig.)

  1. Biokinetics of ultrafine gold nanoparticles (AuNPs) relating to redistribution and urinary excretion: a long-term in vivo study.

    Science.gov (United States)

    Naz, Farhat; Koul, Veena; Srivastava, Amita; Gupta, Yogendra Kumar; Dinda, Amit Kumar

    2016-09-01

    Gold nanoparticles (AuNPs) of ultrafine size have drawn attention for their use in drug delivery systems. Tissue toxicity may be an issue when AuNPs are used for such applications. We investigated the long-term biokinetics (90 d), redistribution, and urinary excretion of three different-sized (2 ± 0.5 nm, 5 ± 1 nm, and 10 ± 2 nm) AuNPs after a single intravenous (i.v.) administration of 1250 µg/kg dose in mice. ICP-AES analysis of lungs, liver, spleen, heart, kidney, brain, blood, and urine revealed highest accumulation of gold in spleen around 15 d after injection. A low concentration was detected in brain after 1 d without any residual AuNPs after 30 d. Ultrastructural study of brain tissue also showed few AuNPs in lysosome with no changes in cellular architecture. Renal retention of AuNPs was limited indicating low nephrotoxic potential. AuNPs were detectable in urine till 30 d after single injection indicating slow excretion from the body. No evidence of significant toxicity was observed in hemogram, serum biochemistry, and tissue histology. No mortality, changes in behavior, hair color, weight, and food intake was observed as compared to control mice. Therefore, we conclude that the ultrafine AuNPs are predominantly excreted in urine without any systemic toxicity following i.v. administration and are hence safe for use in drug delivery systems.

  2. Dimer of the peptide cycle (Ar-Gly-Asp-D-Phe-Lys) radiolabeled with 99mTc for the integrin s over-expression image: formulation, biokinetics and dosimetry

    International Nuclear Information System (INIS)

    Ortiz A, Z.

    2013-01-01

    In breast cancer, α(v)β(3) and/or α(v)β(5) integrin s are over-expressed in both endothelial and tumour cells. Radiolabeled peptides based on the RGD (Arg-Gly-Asp) sequence are radiopharmaceuticals with high affinity and selectivity for those integrin s. The RGD-dimer peptide (E-[c(RGDfK)] 2 ) radiolabeled with 99m Tc has been reported as a radiopharmaceutical with 10-fold higher affinity for the α(v)β(3) integrin as compared to the RGD-monomer. EDDA (Ethylenediamine-N,N-diacetic acid) is a hydrophilic molecule that may favours renal excretion when used as coligand in the 99m Tc labelling of HYNIC-peptides and can easily be formulated in a lyophilized kit. Aim: Establish a biokinetic model for 99m Tc-EDDA/HYNIC-E-[c(RGDfK)] 2 prepared from lyophilized kits and evaluate the dosimetry as breast cancer imaging agent. Methods: 99m Tc labelling was performed by addition of sodium pertechnetate solution and 0.2 M phosphate buffer ph 7.0 to a lyophilized formulation containing E-[c(RGDfK)] 2 , EDDA, tricine, mannitol and stannous chloride. Radiochemical purity was evaluated by reversed phase HPLC and ITLC-SG analyses. Stability studies in human serum were carried out by size-exclusion HPLC. In-vitro cell uptake was tested using breast cancer cells (MCF7, T47D and MDA-MB-231) with blocked and non-blocked receptors. Biodistribution and tumour uptake were determined in MCF7 tumour-bearing nude mice with blocked and non-blocked receptors, and images were obtained using a micro-SPECT/CT. Whole-body images from seven healthy women were acquired at 1, 3, 6 and 24 h after 99m Tc-EDDA/HYNIC-E-[c(RGDfK)] 2 administration obtained with radiochemical purities of >94 %. Regions of interest (ROIs) were drawn around source organs on each time frame. Each ROI was converted to activity using the conjugate view counting method. The image sequence was used to extrapolate 99m Tc-EDDA/HYNIC-E-[c(RGDfK)] 2 time-activity curves in each organ in order to adjust the biokinetic model and to

  3. Sentinel lymph node diagnostic in prostate carcinoma. Part II. Biokinetics and dosimetry of 99mTc-nanocolloid after intraprostatic injection

    International Nuclear Information System (INIS)

    Wengenmair, H.; Kopp, J.; Vogt, H.; Groeber, S.; Dorn, R.; Heidenreich, P.; Wawroschek, F.

    2002-01-01

    Aim: To visualise the sentinel lymph nodes (SLNs) of the prostate we injected the radiotracer into the parenchyma of the prostate. The activity was deposited in liver, spleen, bone marrow, urinary bladder and regional lymphatic system. The aim of this work is to determine biokinetical data and to estimate radiation doses to the patient. Methods: The patients with prostate cancer received a sonographically controlled, transrectal administration of 99m Tc-Nanocoll trademark, injected directly into both prostate lobes. In 10 randomly selected patients radionuclide distribution and its time course was determined via regions of interest (ROIs) over prostate, urinary bladder, liver, spleen and the lymph nodes. The uptake in the SLNs was estimated from gamma probe measurements at the surgically removed nodes. To compare tumour positive with tumour free lymph nodes according to SLN-uptake and SLN-localisation we evaluated 108 lymph nodes out of 24 patients with tumour positive SLN. For calculating the effective dose according to ICRP 60 of the patients we used the MIRD-method and the Mirdose 3.1 software. Results: The average uptake of separate organs was: bladder content 24%, liver 25.5%, spleen 2%, sum of SLN 0.5%. An average of 9% of the applied activity remained in the prostate. The residual activity was mainly accumulated in bone marrow and blood. Occasionally a weak activity enrichment in intestinal tract and kidneys could be recognized. The effective dose to the patient was estimated to 7.6 μSv/MBq. The radioactivity uptake of the SLN varied in several orders of magnitude between 0.006% and 0.6%. The probability of SLN-metastasis was found to be independent from tracer uptake in the lymph node. The radioactivity uptake of the SLNs in distinct lymph node regions showed no significant differences. Conclusion: The radiotracer is transferred out of the prostate via blood flow, by direct transfer via the urethra into the bladder and by lymphatic transport. Injecting a

  4. Biokinetics and dosimetry of {sup 99m} Tc-EDDA/HYNIC-[Lys{sup 3}]-bombesin in humans: imaging of GRP receptors

    Energy Technology Data Exchange (ETDEWEB)

    Santos C, C.L.; Ferro F, G. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico); Murphy, C.A de [INCMNSZ, 14000 Mexico D.F. (Mexico); Cardena, E.; Pichardo R, P. [Departamento de Medicina Nuclear, Oncologia Centro Medico Siglo XXI, Mexico D.F. (Mexico)

    2007-07-01

    Full text: Bombesin (BN) receptor subtype 2 (GRP-r) is over-expressed on various human tumors including breast, prostate, small cell lung and pancreatic cancer. Recently we reported the {sup 99-}mTc-EDDA/HYNIC-[Lys{sup 3}]-Bombesin ({sup 99m}Tc-HYNIC-BN) complex as a new radiopharmaceutical with high stability in human serum, specific cell GRP-receptor binding and rapid internalization. The aim of this study was to evaluate the {sup 99m}Tc-HYNIC-BN biokinetics and dosimetry in 5-healthy and 3-breast cancer women. Whole-body images were acquired at 20, 90, 180 min and 24 h after {sup 99m}Tc-HYNIC-BN administration. Regions of interest (ROIs) were drawn around source' organs on each time frame. The same set of ROIs was used for all 8 scans and the cpm of each ROI was converted to activity using the conjugate view counting method. The image sequence was used to extrapolate {sup 99m}Tc-HYNIC-BN time activity curves in each organ, to calculate the total number of disintegrations (N) that occurred in the source regions. N data were the input for the OLINDA/EXM code to calculate internal radiation dose estimates. Images showed a rapid radiopharmaceutical blood clearance with predominantly renal excretion and minimal hepatobiliary elimination. {sup 99m}Tc-HYNIC-BN exhibited high in vivo affinity for GRP-r over-expression successfully visualized in breast cancer lesions and well differentiated from GRP-r expression in lungs and airways with normal GRP-r density (ratio 3:1). The equivalent doses for a study using 370 MBq were 7.38{+-}1.68, 0.59{+-}0.08, 2.07{+-}0.60, 0.58{+-}0.1, 0.75{+-}0.09 and 0.43{+-}0.07 mSv for kidneys, liver, lungs, ovaries, pancreas and red marrow respectively. The effective dose was 1.64{+-}0.25 mSv which is comparable with the doses known for most of the {sup 99m}Tc radiopharmaceutical studies in nuclear medicine. (Author)

  5. Bibliographic study on molybdenum biokinetics

    International Nuclear Information System (INIS)

    Erzberger, A.

    1988-05-01

    This bibliographical study compiles and analyzes findings about the metabolism and resorption of molybdenum. Besides including studies on the physiology of molybdenum 99, a general survey is given on molybdenum in the environment and on its physiological behaviour. In particular, information on the dependence of molybdenum resorption on various factors, such as the chemical form, antagonisms etc., are gathered from literature. These factors have to be considered for sensibly carrying out necessary experiments. (orig./MG) [de

  6. ASM1-based activated sludge model with biopolymer kinetics for integrated simulation of membrane bioreactors for wastewater treatment

    OpenAIRE

    Janus, Tomasz; Ulanicki, Bogumil

    2015-01-01

    This paper presents an activated sludge model suitable for modelling membrane bioreactors (MBRs) for wastewater treatment. The model, later referred to as combined EPS and SMP production ASM1-based model (CES-ASM1), extends Activated Sludge Model No. 1 (ASM1) with biokinetics of two types of bacterial biopolymers: soluble microbial products (SMP) and extracellular polymeric substances (EPS). The biopolymer kinetics in CES-ASM1 are, in their majority, borrowed from Laspidou and Rittmann[1] ...

  7. Matrix modulation of the toxicity of alkenylbenzenes, studied by an integrated approach using in vitro, in vivo, and physiologically based biokinetic models

    NARCIS (Netherlands)

    Al-Husainy, W.A.A.M.

    2013-01-01

    Alkenylbenzenes such as estragole and methyleugenol are common components of spices and herbs such as tarragon, basil, fennel, mace, allspice, star anise and anise and their essential oils (Smithet al.,

  8. Matrix modulation of the toxicity of alkenylbenzenes, studied by an integrated approach using in vitro, in vivo, and physiologically based biokinetic models

    NARCIS (Netherlands)

    Al-Husainy, W.A.A.M.

    2013-01-01

    Alkenylbenzenes such as estragole and methyleugenol are common components of spices and herbs such as tarragon, basil, fennel, mace, allspice, star anise and anise and their essential oils (Smithet al., 2002). There is an interest in the safety evaluation of alkenylbenzenes because

  9. Dosimetric evaluation in organs of the Tc{sup 99m}, I{sup 123} bio-kinetics to estimate dose in thyroid children 1 and 5 years; Evaluacion dosimetrica en organos de la biocinetica del Tc{sup 99m}, I{sup 123} para estimar dosis en tiroides ninos 1 y 5 anos

    Energy Technology Data Exchange (ETDEWEB)

    Vasquez, A. M.; Quispe, R.; Vasquez, D. J.; Rocha, M. D.; Morales, N. R.; Marin, R. K. [Universidad Nacional de Trujillo, Av. Juan Pablo II s/n, Ciudad Universitaria, Trujillo (Peru); Zelada, A. L., E-mail: marvva@hotmail.com [Universidad Cesar Vallejo, Grupo de Fisica Medica, Av. Larco s/n, Trujillo (Peru)

    2012-10-15

    Using the formalism MIRD and the representation of Cristy-Eckerman for the thyroid in children of 1 and 5 years, is demonstrated that the dosimetric contribution of the organs of I{sup 123} (iodure) bio-kinetics is not significant in the dose estimate. The total dose absorbed by the gland is its auto dose. The dosimetric contribution of the organs source of the Tc{sup 99m} (pertechnetate) bio-kinetics in the gland is significant in the dose estimate like to be ignored. The reported results for the iodure are not significantly different to the found for the Marinelli scheme (auto-dose) for thyroid represented by a sphere of 1,78 and 3,45 grams. (Author)

  10. Empleo de isótopos radiactivos en estudios biocinéticos con animales de experimentación Use of radioisotopes in biokinetic models with experimental animals

    Directory of Open Access Journals (Sweden)

    F. R. Martín Martín

    2002-06-01

    Full Text Available En el presente trabajo se pretende realizar una revisión de las diferentes técnicas radioisotópicas que se utilizan con animales de experimentación a la hora de desarrollar modelos biocinéticos tanto de sustancias como de elementos químicos presentes en el medio ambiente. Dicha experimentación permite relacionar la exposición externa a un xenobiótico con la medida interna de la dosis en el organismo y, consecuentemente, sus posibles efectos tóxicos, todo ello con vistas a evaluar los efectos adversos que pudieran existir sobre la salud humana. Se hace hincapié en la macroautorradiografía de animal completo, técnica que permite la detección, localización y cuantificación del radionucleido de interés en diferentes órganos/tejidos del organismo y, por tanto, contribuye a la estimación de la dosis interna y al conocimiento del comportamiento biocinético del compuesto/elemento objeto de estudio. Se presentan algunos ejemplos de la utilidad de esta técnica en estudios biocinéticos con animales de experimentación de interés en diferentes áreas relacionadas con la Salud y el Medio Ambiente. Se destaca la utilidad que presenta esta experimentación a la hora de extrapolar el comportamiento metabólico de contaminantes de máxima radiotoxicidad en personas expuestas a la radiación ionizante, con el objeto de optimizar las evaluaciones dosimétricas y los protocolos de vigilancia que ayudan a conocer con más exactitud los daños de la exposición interna sobre la salud humana.Biokinetic models are useful tools to relate external exposures to internal measures of dose. The knowledge of internal dose and factors that influence absorption, distribution, metabolism, and elimination in experimental animals provide a scientific rationale for estimating low-dose human risk. A bioanalytical procedure to support biokinetic studies is the use of radiolabeled compounds, so that mass balance, autoradiography, and preliminary metabolism

  11. Dosimetric contribution of the organs of the I{sup 123}, I{sup 124} and I{sup 131} bio-kinetics in the dose estimate for euthyroid adults; Contribucion dosimetrica de los organos de la biocinetica de I{sup 123}, I{sup 124} y I{sup 131} en el estimado de dosis para adultos eutiroideos

    Energy Technology Data Exchange (ETDEWEB)

    Vasquez, A. M.; Rojas, A. R.; Castillo, D. C.; Idrogo, C. J.; Flores, U. H., E-mail: marvva@hotmail.com [Universidad Nacional de Trujillo, Av. Juan Pablo II s/n, Ciudad Universitaria, Trujillo (Peru)

    2011-10-15

    Using the formalism MIRD and the representation of Crysty-Eckerman for the thyroid adult, is demonstrated that the dosimetric contributions of source organs of the biokinetics of the radiopharmaceuticals I{sup 123}, I{sup 124} and I{sup 131} (iodine) are not significant in the dose estimate. Therefore, the total absorbed dose by the gland is its auto-dose. Equally, the reported results do not present significant differences to the results found by the Marinelli scheme (auto-dose) for the thyroid represented by a sphere of 20 grams. (Author)

  12. Dimer of the peptide cycle (Ar-Gly-Asp-D-Phe-Lys) radiolabeled with {sup 99m}Tc for the integrin s over-expression image: formulation, biokinetics and dosimetry; Dimero del peptido ciclo(Arg-Gly-Asp-D-Phe-Lys) radiomarcado con {sup 99m}Tc para la imagen de sobre-expresion de integrinas: formulacion, biocinetica y dosimetria

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz A, Z.

    2013-07-01

    In breast cancer, α(v)β(3) and/or α(v)β(5) integrin s are over-expressed in both endothelial and tumour cells. Radiolabeled peptides based on the RGD (Arg-Gly-Asp) sequence are radiopharmaceuticals with high affinity and selectivity for those integrin s. The RGD-dimer peptide (E-[c(RGDfK)]{sub 2}) radiolabeled with {sup 99m}Tc has been reported as a radiopharmaceutical with 10-fold higher affinity for the α(v)β(3) integrin as compared to the RGD-monomer. EDDA (Ethylenediamine-N,N-diacetic acid) is a hydrophilic molecule that may favours renal excretion when used as coligand in the {sup 99m}Tc labelling of HYNIC-peptides and can easily be formulated in a lyophilized kit. Aim: Establish a biokinetic model for {sup 99m}Tc-EDDA/HYNIC-E-[c(RGDfK)]{sub 2} prepared from lyophilized kits and evaluate the dosimetry as breast cancer imaging agent. Methods: {sup 99m}Tc labelling was performed by addition of sodium pertechnetate solution and 0.2 M phosphate buffer ph 7.0 to a lyophilized formulation containing E-[c(RGDfK)]{sub 2}, EDDA, tricine, mannitol and stannous chloride. Radiochemical purity was evaluated by reversed phase HPLC and ITLC-SG analyses. Stability studies in human serum were carried out by size-exclusion HPLC. In-vitro cell uptake was tested using breast cancer cells (MCF7, T47D and MDA-MB-231) with blocked and non-blocked receptors. Biodistribution and tumour uptake were determined in MCF7 tumour-bearing nude mice with blocked and non-blocked receptors, and images were obtained using a micro-SPECT/CT. Whole-body images from seven healthy women were acquired at 1, 3, 6 and 24 h after {sup 99m}Tc-EDDA/HYNIC-E-[c(RGDfK)]{sub 2} administration obtained with radiochemical purities of >94 %. Regions of interest (ROIs) were drawn around source organs on each time frame. Each ROI was converted to activity using the conjugate view counting method. The image sequence was used to extrapolate {sup 99m}Tc-EDDA/HYNIC-E-[c(RGDfK)]{sub 2} time-activity curves in each

  13. Biokinetic of plutonium in human beings. Analysis and modification of ICRP 67 model; Biocinetica del plutonio nell'organismo umano. Analisi e modifica del modello ICRP 67

    Energy Technology Data Exchange (ETDEWEB)

    Luciani, A.; Castellani, C.M. [ENEA, Divisione Protezione dell' Uomo e degli Ecosistemi, Centro Ricerche Ezio Clementel, Bologna (Italy)

    2001-07-01

    A preliminary research of the available data and empirical functions for the plutonium excretion after injection was carried out. The ICRP model presented in the Publication no. 67 was then analyzed comparing its predictions for the activity in urine and, at a lesser extent, in feces and blood, with the collected data and empirical curves. The model was modified and an optimized age-related compartmental model was developed. A new skeletal model recently developed was also introduced and age depending bone remodelling rates were assumed on the basis of the ICRP Publication 70. This model provides a better agreement with measured urinary excretion data than the current ICRP 67 model, avoiding unphysiological assumptions such as the transfer of activity from soft tissue to urinary bladder, that were part of the ICRP model. The new optimized model predictions of the activity in faeces and in blood after an injection are also closer to the available data than the ICRP 67 estimations. A good agreement with the partitioning factor of plutonium between skeleton and liver obtained from different autopsy studies was also observed. [Italian] E' stata effettuata preliminarmente una ricerca bibliografica dei dati e delle funzioni di escrezione del plutonio attualmente disponibili in letteratura. Sulla base dei risultati di tale ricerca e' stato verificato il modello proposto dall'ICRP nella Pubblicazione n. 67. Tale modello e' stato quindi modificato al fine non solo di avere una piu' realistica descrizione dei valori predetti per l'escrezione urinaria, ma anche di modellare la cinetica del plutonio evitando quelle assunzioni introdotte appositamente nel modello dell'ICRP per correggere le previsini del modello ma che mancano di una chiara spiegazione di carattere fisiologico. Esso fornisce valutazioni piu' realistiche anche per l'attivita' nelle feci e nel sangue. Il modello sviluppato comprende un modello scheletrico

  14. Biokinetics and Biodynamics of Nanomaterial Interactions

    Science.gov (United States)

    2009-09-30

    onspecific interactions between the Ag NP ncrease in absorbance at the highest dosing P. The unwashed 20nm (Figure 5a), 50nm significant increase in...the molecular interactions of the probe compounds with the surface of the nanoparticle. The competitive adsorption of the diverse compounds reveals the...MNM) and its interaction with biological systems, very complicated adsorption mechanisms could be involved (e.g. competitive probe adsorption

  15. Biokinetics and dosimetry in patients of {sup 99m}Tc-HYNIC-Lys{sup 3}-Bombesin: images of GRP receptors; Biocinetica y dosimetria en humanos de {sup 99m}Tc-HYNIC-Lys{sup 3}-Bombesina: imagenes de receptores GRP

    Energy Technology Data Exchange (ETDEWEB)

    Santos C, C. L. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2007-07-01

    The bombesin (BN) receptor subtype 2 (GRP-r) is expressed in several normal human tissues and is over-expressed in various human tumors including breast, prostate, small cell lung and pancreatic cancer. Recently [{sup 99m}Tc]EDDA/HYNIC-Lys{sup 3}-bombesin ({sup 99m}Tc-HYNIC-BN) was reported as a radiopharmaceutical with high stability in human serum, specific cell GRP-r binding and rapid cell internalization. The aim of this study was to evaluate the feasibility of using {sup 99m}Tc-HYNIC-BN to image GRP-r and to assess the radiopharmaceutical biokinetics and dosimetry in 4 breast cancer patients and in 7 healthy women. Methods: Whole-body images were acquired at 20, 90, 180 min and 24 h after {sup 99m}Tc-HYNIC-BN administration. Regions of interest (ROIs) were drawn around source organs on each time frame. The same set of ROIs was used for all 11 scans and the cpm of each ROI was converted to activity using the conjugate view counting method. The image sequence was used to extrapolate {sup 99m}Tc-HYNIC-BN time-activity curves in each organ in order to calculate the total number of disintegrations (N) that occurred in the source regions, according with MIRD methodology. N data were the input for the OLINDA/EXM code to calculate internal radiation dose estimates. Results: Images showed a rapid radiopharmaceutical blood clearance with renal excretion as predominant route. {sup 99m}Tc-HYNIC-BN exhibited high in vivo affinity for GRP-r over-expression successfully visualized in cancer mammary glands and well differentiated from the ubiquitous GRP-r expression in normal breast, lungs and airways. There was no statistically significant difference (p > 0.05) in the radiation absorbed doses between cancer patients and healthy women. The average equivalent doses (n=11) for a study using 740 MBq were 24.8 +- 8.8 mSv (kidneys), 7.3 +- 1.8 mSv (lungs), 6.5 +- 4.0 mSv (breast) 2.0 +- 0.3 mSv (pancreas), 1.6 +- 0.3 mSv (liver), 1.2 +- 0.2 mSv (ovaries) and 1.0 +- 0.2 mSv (red

  16. Physiologically based pharmacokinetic modeling of 18F-SiFAlin-Asp3-PEG1-TATE in AR42J tumor bearing mice

    International Nuclear Information System (INIS)

    Maaß, Christian; Rivas, Jose Ricardo Avelar; Attarwala, Ali Asgar; Hardiansyah, Deni; Niedermoser, Sabrina; Litau, Shanna; Wängler, Carmen; Wängler, Björn; Glatting, Gerhard

    2016-01-01

    Purpose: Peptide receptor radionuclide therapy (PRRT) is commonly performed in the treatment of neuroendocrine tumors (NET), where somatostatin analogs (DOTATATE) are radiolabeled with 90 Y, 68 Ga or 111 In for pre-therapeutic and therapeutic purposes. Quantitative evaluation of the biokinetic data can be performed by using physiologically based pharmacokinetic (PBPK) models. Knowledge about the biodistribution in a pre-clinical setting would allow optimizing the translation from bench to bedside. The aim of this study was to develop a PBPK model to describe the biodistribution of a novel sst2-targeting radiotracer. Methods: Biokinetic data of six mice after injection of 18 F-SiFAlin-Asp 3 -PEG 1 -TATE were investigated using two PBPK models. The PBPK models describe the biodistribution of the tracer in the tumor, kidneys, liver, remainder and whole body via blood flow to these organs via absorption, distribution, metabolism and excretion. A recently published sst2 PBPK model for humans (model 1) was used to describe the data. Physiological information in this model was adapted to that of a mouse. Model 1 was further modified by implementing receptor-mediated endocytosis (model 2). Model parameters were fitted to the biokinetic data of each mouse. Model selection was performed by calculating Akaike weights w i using the corrected Akaike Information Criterion (AICc). Results: The implementation of receptor-mediated endocytosis considerably improved the description of the biodistribution (Akaike weights w 1 = 0% and w 2 = 100% for model 1 and 2, respectively). The resulting time-integrated activity coefficients determined by model 2 were for tumor (0.05 ± 0.02) h, kidneys (0.11 ± 0.01) h and liver (0.02 ± 0.01) h. Conclusion: Simply downscaling a human PBPK model does not allow for an accurate description of 18 F-SiFAlin-Asp 3 -PEG 1 -TATE in mice. Biokinetics of this tracer can be accurately and adequately described using a physiologically based pharmacokinetic

  17. Radiation exposure of the patient in diagnostic nuclear medicine. Experimental studies of the biokinetics of {sup 111}In-DTPA-D-Phe{sup 1}-octreotide, {sup 99m}Tc-MIBI, {sup 14}C-triolein and {sup 14}C-urea, and development of dosimetric models

    Energy Technology Data Exchange (ETDEWEB)

    Leide Svegborn, S

    1999-03-01

    Biokinetic and dosimetric models for a number of clinically used radiopharmaceuticals, for which information on the radiation dosimetry is scarce, have been produced. On patients undergoing investigations with {sup 111}In-DTPA-D-Phe{sup 1}-octreotide (for diagnosis of neuroendocrine tumours) and {sup 99m}Tc-MIBI (for myocardial perfusion imaging), whole body gamma camera scanning was performed several times after administration of the radiopharmaceutical. Total body and organ activity content was determined using the geometric mean of the number of counts in two 180 deg opposed planar images. A thorough investigation of sources influencing the accuracy of the quantification of activity was carried out, showing an overall uncertainty varying from 10% to 30% for organs with a significant uptake and 5% for the whole body. The activity in blood and urine was also measured. {sup 111}In-DTPA-D-Phe{sup 1}-octreotide was predominantly excreted via the kidney-bladder system and a typical investigation with 1200 MBq resulted in an effective dose of 8.4 mSv (0.076 mSv/MBq). {sup 99m}Tc-MIBI was to a great extent excreted via the gastrointestinal tract and an investigation with 1200 MBq resulted in an effective dose of 13 mSv (0.011 mSv/MBq). Accelerator mass spectrometry (AMS) was used to investigate the possibility to measure ultra-low activity concentrations of {sup 14}CO{sub 2}, in exhaled air from patients undergoing {sup 14}C-breath tests, with special application to {sup 14}C-triolein (for study of fat malabsorption). AMS was proven to be a useful technique for long-term retention studies of {sup 14}C, and was used together with liquid scintillation counting in an investigation of the biokinetics of {sup 14}C-urea in adult and paediatric patients (for diagnosis of Helicobacter pylori infection in the upper gastrointestinal tract). The effective dose for {sup 14}C-urea was 0.019 mSv/MBq for adults and from 0.041 to 0.019 mSv/MBq for seven- to fourteen -year-old children

  18. Radiation exposure of the patient in diagnostic nuclear medicine. Experimental studies of the biokinetics of 111In-DTPA-D-Phe1-octreotide, 99mTc-MIBI, 14C-triolein and 14C-urea, and development of dosimetric models

    International Nuclear Information System (INIS)

    Leide Svegborn, S.

    1999-03-01

    Biokinetic and dosimetric models for a number of clinically used radiopharmaceuticals, for which information on the radiation dosimetry is scarce, have been produced. On patients undergoing investigations with 111 In-DTPA-D-Phe 1 -octreotide (for diagnosis of neuroendocrine tumours) and 99m Tc-MIBI (for myocardial perfusion imaging), whole body gamma camera scanning was performed several times after administration of the radiopharmaceutical. Total body and organ activity content was determined using the geometric mean of the number of counts in two 180 deg opposed planar images. A thorough investigation of sources influencing the accuracy of the quantification of activity was carried out, showing an overall uncertainty varying from 10% to 30% for organs with a significant uptake and 5% for the whole body. The activity in blood and urine was also measured. 111 In-DTPA-D-Phe 1 -octreotide was predominantly excreted via the kidney-bladder system and a typical investigation with 1200 MBq resulted in an effective dose of 8.4 mSv (0.076 mSv/MBq). 99m Tc-MIBI was to a great extent excreted via the gastrointestinal tract and an investigation with 1200 MBq resulted in an effective dose of 13 mSv (0.011 mSv/MBq). Accelerator mass spectrometry (AMS) was used to investigate the possibility to measure ultra-low activity concentrations of 14 CO 2 , in exhaled air from patients undergoing 14 C-breath tests, with special application to 14 C-triolein (for study of fat malabsorption). AMS was proven to be a useful technique for long-term retention studies of 14 C, and was used together with liquid scintillation counting in an investigation of the biokinetics of 14 C-urea in adult and paediatric patients (for diagnosis of Helicobacter pylori infection in the upper gastrointestinal tract). The effective dose for 14 C-urea was 0.019 mSv/MBq for adults and from 0.041 to 0.019 mSv/MBq for seven- to fourteen -year-old children, resulting in an effective dose of approximately 0.002 mSv per

  19. Biokinetics and dosimetry of a hybrid formulation of {sup 9{sup m}}Tc-BN and {sup 99m}Tc-RGD{sub 2} starting from optic images in a murine model; Biocinetica y dosimetria de una formulacion hibrida de {sup 99m}Tc-BN y {sup 99m}Tc-RGD{sub 2} a partir de imagenes opticas en un modelo murino

    Energy Technology Data Exchange (ETDEWEB)

    Cornejo A, L. G.

    2015-07-01

    This work has the purpose of evaluate the biokinetics and absorbed dose of radiation of hybrid formulation {sup 99m}Tc-BN /{sup 99m}Tc-RGD{sub 2} in a murine model by optical imaging techniques using the multimodal preclinical in vivo image system Xtreme. The used method were the {sup 99m}Tc-BN, {sup 99m}Tc-RGD{sub 2} and {sup 99m}Tc-BN/{sup 99m}Tc-RGD{sub 2} formulas, with specific recognition for GRPr and the integrin s α(v)β(3) and α(v)β(5) respectively, was injected in the vein tail of three nude mousses with induce breast cancer tumors (cell line T-47-D), by the preclinical multimodal imaging system Xtreme (Bruker), optical images in different times was acquired (5, 10, 20 min, 2 and 24 h), using Images Processing Toolbox of MATLAB these images was transform from RGB format to gray scales and sectioned in five independent images corresponding to heart, kidneys, bladder and tumor areas. The intensity of each images was computed in counts per pixel, then those intensities was corrected for background, attenuation and scattering, using different factors for each phenomena previously calculated. Finally the activity values quantified vs time was fitted into a biokinetic model to obtain the disintegrations number and cumulate activities in each organ. With these data the radiation absorbed dose were calculated using MIRD methodology. Results: The number of disintegration and absorbed dose calculated in MBq h/MBq and mGy/MBq, of injected mouse with the {sup 99m}Tc-BN/{sup 99m}Tc-RGD{sub 2} formulation, was: 0.035 ± 0.65 E-02, 0.25 x 10{sub -5} ± 0.46 E-07; 0.393 ± 0.51 E-1, 2.85 E-05 ± 3.7 E-06; 0.306 ± 0.21 E-01, 2.11 E-05 ± 1.45 E-06 and 0.151 ± 0.19 E-01, 1.09 E-05 ± 1.42 E-06 , in heart, kidneys, bladder and tumor, respectively. The number of disintegration obtained in kidneys is comparable to those reported for Trinidad B. 2014 Conclusions: Our results demonstrated that using optical images and a code for image analyses development in MATLAB, could

  20. Annual limits on intake of radionuclides by workers based on the 1990 recommendations

    International Nuclear Information System (INIS)

    1991-01-01

    The Commission's new radiation protection recommendations (ICRP, 1991) were developed to take into account new biological information related to the detriment associated with radiation exposures and supersede earlier recommendations in Publication 26 (ICRP, 1977). Adoption of the recommendations necessitates a revision in the Commission's secondary limits contained in Publication 30, Parts 1-4 (ICRP, 1979a, 1980, 1981b, 1988). In order to permit immediate application of these new recommendations, new values of the Annual Limits on Intake (ALIs) which incorporate the new dose limits, radiation weighting factors, and tissue weighting factors and the metabolic and biokinetic information from Publication 30 have been calculated. Presented here are secondary limits for the 1990 Recommendations based on the dosimetric data assembled during the preparation of Publication 30. (author)

  1. Synthesis, labeling with {sup 99m}Tc and biokinetics of brains scintigraphy diaminodithiol perfusion radiopharmaceuticals; Sintese, marcacao com {sup 99m}Tc e biocinetica de radiofarmacos perfusorios diaminoditiolicos para cintilografias cerebrais

    Energy Technology Data Exchange (ETDEWEB)

    Goncalves, Marcos Moises

    1999-07-01

    The recent tomography status using radiopharmaceuticals have been contributing greatly with the 'age of certainty' in the diagnosis examination of syndromes, pathologies and clinical signs, because they can evidence some phenomena occurring in a molecular manner. The purpose of this work have had the development of new diaminodithiol (DADT) perfusion radiopharmaceuticals to be used in brain diagnosis using S.P.E.T. (Single Photon Emission Tomography). Initially, the rational planning had been performed with the new DADT molecular structures as radiopharmaceutical candidates. Using of Q.S.A.R. (Quantitative Structure Activity Relationship) techniques, the molecular descriptors such as partition coefficient and effective polarizability, have been studied in order to increase the blood brain barrier transport and the brain uptake respectively. Applying the Q.S.P.R. (Quantitative Structure Property Relationship) concepts to perform drug latentiation, based on bio-labile functional groups, the congener DADT derivative has been transformed into a pro-drug that works as a DADT moiety carrier, allowing the increasing of brain radiopharmaceutical uptake. Later on, synthetic routes and chemical purifications have been developed allowing the creation of the proposed chemical structure. Each new DADT derivative has been synthesized and analyzed in terms of elemental analysis, infrared and NMR spectra, in order to confirm its proposed chemical structure. Then, the new derivative has been labeled with {sup 99m}Tc, radiochemically purified, intravenously injected in Swiss mice, allowing its biodistribution to evidence its brain transport and uptake. The rational planning studies have been re-evaluated after each biodistribution had been performed, to see what kind of molecular descriptor was responsible for causing a stronger optimization in the brain perfusion characteristics and then, new DADT derivatives have been prepared. Three new DADT derivatives have been

  2. Biokinetic characterization of the acceleration phase in autotrophic ammonia oxidation.

    Science.gov (United States)

    Chandran, Kartik; Smets, Barth F

    2008-08-01

    Batch autotrophic ammonia oxidation tracked through oxygen uptake measurements displays a preliminary acceleration phase. Failure to recognize the acceleration phase and fitting batch ammonia oxidation profiles with standard Monod-type mathematical models can result in meaningless kinetic parameter estimates. The objectives of this study were to examine the factors controlling the acceleration phase and to derive and test empirical and metabolic models for its description. Because of possible sustained reducing power limitation during batch ammonia oxidation, the extent of the acceleration phase (1) increased with increasing initial ammonia concentration, (2) did not systematically vary with initial biomass concentrations, and (3) increased in response to starvation. Concurrent hydroxylamine oxidation significantly reduced the acceleration phase potentially by relieving reducing power limitation. A nonlinear empirical model described the acceleration phase more accurately than a linear empirical model. The metabolic model also captured experimental trends exceedingly well, but required determination of additional parameters and variables.

  3. Biokinetic aspects of tissue-bound tritium in algae

    International Nuclear Information System (INIS)

    Strack, S.; Kistner, G.

    1978-01-01

    For the estimate of the radiation exposure of man and for the calculation of the risk of artificial tritium from nuclear power plants, organic tissue-bound tritium is of decisive importance. In model experiments, a tritium incorporation of 61 to 71% was found from tritiated water (HTO) into organic matter of planctonic algae under reproducible conditions and this was related to the theoretical value. In further experiments the tritium release from these high tritiated algae was of interest. Kept in darkness in tritium-free, non-sterile river water, so that autolytic processes and bacterial decomposition could occur, the concentration of HTO was measured over a period of three weeks. A relatively long half-life of tissue-bound tritium was found under various temperature conditions. Therefore it must be considered that a significant retention of tritium in biological matter has to be taken into account in a natural ecosystem. In streams into which the cooling water of a nuclear reactor is released all conditions are found already for a long turnover and cycling of artificial tritium in living organisms as well as the conditions for a favourable transport of tritium by food chains to man. (Auth.)

  4. Evaluating Alternate Biokinetic Models for Trace Pollutant Cometabolism

    DEFF Research Database (Denmark)

    Liu, Li; Binning, Philip John; Smets, Barth F.

    2015-01-01

    Mathematical models of cometabolic biodegradation kinetics can improve our understanding of the relevant microbial reactions and allow us to design in situ or in-reactor applications of cometabolic bioremediation. A variety of models are available, but their ability to describe experimental data...

  5. Bibliographic study on molybdenum biokinetics. Literaturstudie zur Biokinetik von Molybdaen

    Energy Technology Data Exchange (ETDEWEB)

    Erzberger, A.

    1988-05-01

    This bibliographical study compiles and analyzes findings about the metabolism and resorption of molybdenum. Besides including studies on the physiology of molybdenum 99, a general survey is given on molybdenum in the environment and on its physiological behaviour. In particular, information on the dependence of molybdenum resorption on various factors, such as the chemical form, antagonisms etc., are gathered from literature. These factors have to be considered for sensibly carrying out necessary experiments.

  6. Micro-dosing for early biokinetic studies in humans

    International Nuclear Information System (INIS)

    Stenstroem, K.; Sydoff, M.; Mattsson, S.

    2010-01-01

    Micro-dosing is a new concept in drug development that-if implemented in the pharmaceutical industry-would mean that new drugs can be tested earlier in humans than done today. The human micro-dosing concept-or 'Phase 0'-may offer improved candidate selection, reduced failure rates in the drug development line and a reduction in the use of laboratory animals in early drug development, factors which will help to speed up drug development and also reduce the costs. Micro-dosing utilises sub-pharmacological amounts of the substance to open opportunities for early studies in man. Three technologies are used for micro-dosing: accelerator mass spectrometry (AMS), positron emission tomography and liquid chromatography-tandem mass spectrometry. This paper focuses on the principle of AMS and discusses the current status of micro-dosing with AMS. (authors)

  7. Nitrification biokinetics in rapid sand filters for drinking water treatment

    DEFF Research Database (Denmark)

    Tatari, Karolina

    Danmarks drikkevandsforsyning er udelukkende baseret på grundvand – og mere end 2500 vandværker behandler hver dag vand til de danske forbrugere. Selv om denne vandbehandling betegnes som simpel, er den i virkeligheden baseret på komplicerede mikrobielle processer, som vi hidtil har vidst relativ...

  8. Biokinetic studies on 14C-chitosan in rats

    International Nuclear Information System (INIS)

    Jia Minghong; Nishimura, Y.; Watanabe, Y.; Yukawa, M.

    1998-05-01

    The absorption and the basic metabolism of chitosan in rats are investigated. The results indicated that 14 C-chitosan from gastrointestinal tract was absorbed, metabolized and excreted quickly without re-bioavailability. The radioactive compounds perhaps with specifically chemical forms in serum, liver and the contents of small intestines were separated on GPC column and measured by radioactivity counting. A big pile of peaks with the retention volume almost same as that of standard 14 C-chitosan and another sharp one with the retention volume in the range of higher molecular weight same as that of BSA were discovered in analysis respectively for contents of intestine and serum or liver. The sharp peak would disappear if the proteins contained in the serum or liver were removed. In addition, and interesting tail peak, followed with the pile ones and eluted with the retention volume of lower molecular weight range same as that of chitooligosaccharides was also found in each of the 3 samples, ignoring the protein removal or not. These results suggested that most of 14 C-chitosan was not to be digested in intestine. On the other hand, a small amount of 14 C-chitosan was likely to be absorbed directly or after degraded to small molecular compounds into blood, liver and other tissues, and then connected with the proteins. Perhaps it is these trace materials that were playing important roles in reduction of the bioavailability of radiostrontium in rats

  9. Upon biodistribution and biokinetics of radioiodine-labelled diethylstilbestroldiphosphate

    International Nuclear Information System (INIS)

    Mende, T.; Wollny, G.; Gens, J.; Franke, W.G.; Schubert, J.; Kelly, L.U.

    1983-01-01

    Radioiodine-labelled ( 131 I, 125 I, 123 I) diethylstilbestroldiphosphate (DES) was investigated with respect to measuring radio-labelled hormone derivatives in animals and men. DES was injected intravenously in Wistar rats and mammatumor-bearing mice (Carcinoma solidum simplex), and activities were measured in several organs between 10 minutes and 7 days, p.inj. The liver showed strong activity concentration and long-lasting retention, smaller concentrations were found in kidneys, adrenals, blood, abdominal wall and prostate. The tumor concentration between 10 minutes and 15 hours p.inj. was below the blood concentrations and later on up to 7 days in the order of the blood concentrations, however, always significantly exceeding muscle tissue concentrations. Respective measurements were done in men using tissue cylinders from the prostate gained by puncture-biopsy or other tissue specimens gained during surgery. Activity concentration in the liver is high, therefore the scintigraphic visualization of the liver is possible immediately after injection up to 13 days later. Potentially it is a receptor-sensitive scintigraphy of the liver. (orig.) [de

  10. Bio-kinetic energy harvesting using electroactive polymers

    Science.gov (United States)

    Slade, Jeremiah R.; Bowman, Jeremy; Kornbluh, Roy

    2012-06-01

    In hybrid vehicles, electric motors are used on each wheel to not only propel the car but also to decelerate the car by acting as generators. In the case of the human body, muscles spend about half of their time acting as a brake, absorbing energy, or doing what is known as negative work. Using dielectric elastomers it is possible to use the "braking" phases of walking to generate power without restricting or fatiguing the Warfighter. Infoscitex and SRI have developed and demonstrated methods for using electroactive polymers (EAPs) to tap into the negative work generated at the knee during the deceleration phase of the human gait cycle and convert it into electrical power that can be used to support wearable information systems, including display and communication technologies. The specific class of EAP that has been selected for these applications is termed dielectric elastomers. Because dielectric elastomers dissipate very little mechanical energy into heat, greater amounts of energy can be converted into electricity than by any other method. The long term vision of this concept is to have EAP energy harvesting cells located in components of the Warfighter ensemble, such as the boot uppers, knee pads and eventually even the clothing itself. By properly locating EAPs at these sites it will be possible to not only harvest power from the negative work phase but to actually reduce the amount of work done by the Warfighter's muscles during this phase, thereby reducing fatigue and minimizing the forces transmitted to the joints.

  11. Base

    DEFF Research Database (Denmark)

    Hjulmand, Lise-Lotte; Johansson, Christer

    2004-01-01

    BASE - Engelsk basisgrammatik er resultatet af Lise-Lotte Hjulmands grundige bearbejdning og omfattende revidering af Christer Johanssons Engelska basgrammatik. Grammatikken adskiller sig fra det svenske forlæg på en lang række punkter. Den er bl.a. tilpasset til et dansk publikum og det danske...

  12. Technoeconomic evaluation of bio-based styrene production by engineered Escherichia coli.

    Science.gov (United States)

    Claypool, Joshua T; Raman, D Raj; Jarboe, Laura R; Nielsen, David R

    2014-08-01

    Styrene is an important commodity chemical used in polymers and resins, and is typically produced from the petrochemical feedstocks benzene and ethylene. Styrene has recently been produced biosynthetically for the first time using engineered Escherichia coli, and this bio-based route may represent a lower energy and renewable alternative to petroleum-derived styrene. However, the economics of such an approach has not yet been investigated. Using an early-stage technoeconomic evaluation tool, a preliminary economic analysis of bio-based styrene from C(6)-sugar feedstock has been conducted. Owing to styrene's limited water solubility, it was assumed that the resulting fermentation broth would spontaneously form two immiscible liquid phases that could subsequently be decanted. Assuming current C(6) sugar prices and industrially achievable biokinetic parameter values (e.g., product yield, specific growth rate), commercial-scale bio-based styrene has a minimum estimated selling price (MESP) of 1.90 USD kg(-1) which is in the range of current styrene prices. A Monte Carlo analysis revealed a potentially large (0.45 USD kg(-1)) standard deviation in the MESP, while a sensitivity analysis showed feedstock price and overall yield as primary drivers of MESP.

  13. Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods.

    Science.gov (United States)

    Berggren, Elisabet; White, Andrew; Ouedraogo, Gladys; Paini, Alicia; Richarz, Andrea-Nicole; Bois, Frederic Y; Exner, Thomas; Leite, Sofia; Grunsven, Leo A van; Worth, Andrew; Mahony, Catherine

    2017-11-01

    We describe and illustrate a workflow for chemical safety assessment that completely avoids animal testing. The workflow, which was developed within the SEURAT-1 initiative, is designed to be applicable to cosmetic ingredients as well as to other types of chemicals, e.g. active ingredients in plant protection products, biocides or pharmaceuticals. The aim of this work was to develop a workflow to assess chemical safety without relying on any animal testing, but instead constructing a hypothesis based on existing data, in silico modelling, biokinetic considerations and then by targeted non-animal testing. For illustrative purposes, we consider a hypothetical new ingredient x as a new component in a body lotion formulation. The workflow is divided into tiers in which points of departure are established through in vitro testing and in silico prediction, as the basis for estimating a safe external dose in a repeated use scenario. The workflow includes a series of possible exit (decision) points, with increasing levels of confidence, based on the sequential application of the Threshold of Toxicological (TTC) approach, read-across, followed by an "ab initio" assessment, in which chemical safety is determined entirely by new in vitro testing and in vitro to in vivo extrapolation by means of mathematical modelling. We believe that this workflow could be applied as a tool to inform targeted and toxicologically relevant in vitro testing, where necessary, and to gain confidence in safety decision making without the need for animal testing.

  14. Generally applicable limits on intakes of uranium based on its chemical toxicity and the radiological significance of intakes at those limits

    International Nuclear Information System (INIS)

    Thorne, M C; Wilson, J

    2015-01-01

    Uranium is chemically toxic and radioactive, and both considerations have to be taken into account when limiting intakes of the element, in the context of both occupational and public exposures. Herein, the most recent information available on the chemical toxicity and biokinetics of uranium is used to propose new standards for limiting intakes of the element. The approach adopted allows coherent standards to be set for ingestion and inhalation of different chemical forms of the element by various age groups. It also allows coherent standards to be set for occupational and public exposures (including exposures of different age groups) and for various exposure regimes (including short-term and chronic exposures). The proposed standards are more restrictive than those used previously, but are less restrictive than the Minimal Risk Levels proposed recently by the US Agency for Toxic Substances and Disease Registry. Having developed a set of proposed limits based solely on chemical toxicity considerations, the radiological implications of exposure at those proposed limits are investigated for natural, depleted and enriched uranium. (paper)

  15. Synchrotron-based ν-XRF mapping and μ-FTIR microscopy enable to look into the fate and effects of tattoo pigments in human skin.

    Science.gov (United States)

    Schreiver, Ines; Hesse, Bernhard; Seim, Christian; Castillo-Michel, Hiram; Villanova, Julie; Laux, Peter; Dreiack, Nadine; Penning, Randolf; Tucoulou, Remi; Cotte, Marine; Luch, Andreas

    2017-09-12

    The increasing prevalence of tattoos provoked safety concerns with respect to particle distribution and effects inside the human body. We used skin and lymphatic tissues from human corpses to address local biokinetics by means of synchrotron X-ray fluorescence (XRF) techniques at both the micro (μ) and nano (ν) scale. Additional advanced mass spectrometry-based methodology enabled to demonstrate simultaneous transport of organic pigments, heavy metals and titanium dioxide from skin to regional lymph nodes. Among these compounds, organic pigments displayed the broadest size range with smallest species preferentially reaching the lymph nodes. Using synchrotron μ-FTIR analysis we were also able to detect ultrastructural changes of the tissue adjacent to tattoo particles through altered amide I α-helix to β-sheet protein ratios and elevated lipid contents. Altogether we report strong evidence for both migration and long-term deposition of toxic elements and tattoo pigments as well as for conformational alterations of biomolecules that likely contribute to cutaneous inflammation and other adversities upon tattooing.

  16. High Throughput PBPK: Evaluating EPA's Open-Source Data and Tools for Dosimetry and Exposure Reconstruction (SOT)

    Science.gov (United States)

    To address this need, new tools have been created for characterizing, simulating, and evaluating chemical biokinetics. Physiologically-based pharmacokinetic (PBPK) models provide estimates of chemical exposures that produce potentially hazardous tissue concentrations, while tissu...

  17. The role of patient-based treatment planning in peptide receptor radionuclide therapy

    Energy Technology Data Exchange (ETDEWEB)

    Hardiansyah, Deni; Attarwala, Ali Asgar [Heidelberg University, Medical Radiation Physics/Radiation Protection, Universitaetsmedizin Mannheim, Medical Faculty Mannheim, Mannheim (Germany); Universitaetsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Department of Radiation Oncology, Mannheim (Germany); Maass, Christian; Glatting, Gerhard [Heidelberg University, Medical Radiation Physics/Radiation Protection, Universitaetsmedizin Mannheim, Medical Faculty Mannheim, Mannheim (Germany); Mueller, Berthold [University Hospital, RWTH Aachen University, Klinik fuer Nuklearmedizin, Aachen (Germany); Kletting, Peter [Universitaet Ulm, Klinik fuer Nuklearmedizin, Ulm (Germany); Mottaghy, Felix M. [University Hospital, RWTH Aachen University, Klinik fuer Nuklearmedizin, Aachen (Germany); Maastricht University Medical Center (MUMC+), Department of Nuclear Medicine, Maastricht (Netherlands)

    2016-05-15

    Accurate treatment planning is recommended in peptide-receptor radionuclide therapy (PRRT) to minimize the toxicity to organs at risk while maximizing tumor cell sterilization. The aim of this study was to quantify the effect of different degrees of individualization on the prediction accuracy of individual therapeutic biodistributions in patients with neuroendocrine tumors (NETs). A recently developed physiologically based pharmacokinetic (PBPK) model was fitted to the biokinetic data of 15 patients with NETs after pre-therapeutic injection of {sup 111}In-DTPAOC. Mathematical phantom patients (MPP) were defined using the assumed true (true MPP), mean (MPP 1A) and median (MPP 1B) parameter values of the patient group. Alterations of the degree of individualization were introduced to both mean and median patients by including patient-specific information as a priori knowledge: physical parameters and hematocrit (MPP 2A/2B). Successively, measurable individual biokinetic parameters were added: tumor volume V{sub tu} (MPP 3A/3B), glomerular filtration rate GFR (MPP 4A/4B), and tumor perfusion f{sub tu} (MPP 5A/5B). Furthermore, parameters of MPP 5A/5B and a simulated {sup 68}Ga-DOTATATE PET measurement 60 min p.i. were used together with the population values used as Bayesian parameters (MPP 6A/6B). Therapeutic biodistributions were simulated assuming an infusion of {sup 90}Y-DOTATATE (3.3 GBq) over 30 min to all MPPs. Time-integrated activity coefficients were predicted for all MPPs and compared to the true MPPs for each patient in tumor, kidneys, spleen, liver, remainder, and whole body to obtain the relative differences RD. The large RD values of MPP 1A [RD{sub tumor} = (625 ± 1266)%, RD{sub kidneys} = (11 ± 38)% ], and MPP 1B [RD{sub tumor} = (197 ± 505)%, RD{sub kidneys} = (11 ± 39)% ] demonstrate that individual treatment planning is needed due to large physiological differences between patients. Although addition of individual patient parameters reduced the

  18. Biokinetic of plutonium in human beings. Analysis and modification of ICRP 67 model

    International Nuclear Information System (INIS)

    Luciani, A.; Castellani, C. M.

    2001-01-01

    A preliminary research of the available data and empirical functions for the plutonium excretion after injection was carried out. The ICRP model presented in the Publication no. 67 was then analyzed comparing its predictions for the activity in urine and, at a lesser extent, in feces and blood, with the collected data and empirical curves. The model was modified and an optimized age-related compartmental model was developed. A new skeletal model recently developed was also introduced and age depending bone remodelling rates were assumed on the basis of the ICRP Publication 70. This model provides a better agreement with measured urinary excretion data than the current ICRP 67 model, avoiding unphysiological assumptions such as the transfer of activity from soft tissue to urinary bladder, that were part of the ICRP model. The new optimized model predictions of the activity in faeces and in blood after an injection are also closer to the available data than the ICRP 67 estimations. A good agreement with the partitioning factor of plutonium between skeleton and liver obtained from different autopsy studies was also observed [it

  19. Biokinetics and dose estimation of {sup 65}Zn in the salivary gland and male reproductive organs

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, M. [Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba-shi 263-8555 (Japan); Homma-Takeda, S. [Research Center for Radiation Protection, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba-shi 263-8555 (Japan); Nishimura, Y. [Fundamental Technology Center, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba-shi 263-8555 (Japan)

    2007-07-01

    ICRP is revising its recommendations for radiological protection and has added salivary and secretory glands as new target organs. However, little information is available on the distributions of radionuclides in the salivary gland, secretory glands and male reproductive organs. This study deals with the distribution of {sup 65}Zn in the salivary gland and male reproductive organs as a function of time after a single intravenous and oral administration. For the study, 64 Wistar strain male rats, eight weeks of age were used. The rats were periodically sacrificed, the liver, kidney, spleen, pancreas, thymus, salivary gland, testis, epididymitis and prostate gland sampled and the radioactivity of these organs measured with an NaI scintillation counter. The relative concentration of {sup 65}Zn was highest in the prostate gland. We estimated the radiation dose in humans using rat data for the salivary and secretory glands as well as reproductive organs after intake of {sup 65}Zn. (authors)

  20. Evaluation of the various biokinetic models of liberation from characteristic deposition fraction of brazilian population sample

    International Nuclear Information System (INIS)

    Reis, Arlene A. dos; Cardoso, Joaquim C.S.; Lourenco, Maria Cristina

    2005-01-01

    The Publication 66 of International Commission of Radiological Protection (ICRP, 1994) presented the Human Respiratory tract Model that simulates the deposition and translocation of radioactive material in the air that penetrates in the body by inhalation. The main objective of this study is to evaluate the variation in fractional activity absorbed into blood when physiological and morphological parameters from Brazilian population are applied in the deposition model. The clearance model was implemented in the software Excel (version 2000) using a system of differential equations to solve simultaneous process of translocation and absorption of material deposited. After implementation were applied in the model fractional deposition calculated by deposition model using physiological and morphological parameters from Brazilian population. The results show that the variation in the clearance model depends on the material dissolution. For materials of rapid absorption, the variations calculated are not significant. Materials of moderate and slow absorption, presented variation greater than 20% in fractional activity absorbed into blood, depending on levels of exercise. (author)

  1. Absorption and biokinetics of U in rats following an oral administration of uranyl nitrate solution

    Energy Technology Data Exchange (ETDEWEB)

    La Touche, Y.D.; Willis, D.L.; Dawydiak, O.I.

    1987-08-01

    The absorption of U within the male Wistar rat was determined following oral gavage with uranyl nitrate solutions at seven different dosages. Gavage levels ranged from 0.003 to 45 mg U per kilogram body weight. Uranium tissue burdens were determined at 0.25, 0.5, 1, 2, 4, 8, 24, 48, 96 and 240 h following gavage. Blood, kidney, liver and bone were analyzed for U content using neutron activation followed by delayed neutron counting. Uranium rapidly localized in the kidneys and bone following ingestion. Bone was found to be the primary tissue of deposition. Skeletal and kidney burdens closely paralleled each other from 15 min to 10 d after oral gavage. Uranium burdens in the blood reached a maximum within 30 min but declined rapidly thereafter. Burdens of all tissues were well correlated with each other and with dosage at all dose levels. Equations relating body burdens with blood levels were developed and found to be useful for predicting body burdens for the initial 8 h following gavage. Gastrointestinal absorption (f1) was 0.6-2.8% over the range of U administered. Movement of U through the GI tract was assessed at two dosages. The transit time of U through the GI tract was approximately 48 h. Uranium loss from the stomach was described as a power function of time. The maximum value in the small intestine was attained within 2 h, and thereafter its rapid loss was linear up to 8 h. A minor residual loss component from the small intestine was evident beyond 8 h post-gavage.

  2. On the incorporation of biokinetic and mechanistic data in modeling for risk assessment

    NARCIS (Netherlands)

    Clewell, H.J.

    2007-01-01

    The goal of the studies described in this thesis was to foster the increased use of emerging scientific information and innovative methods in chemical risk assessments, in order to assure the protection of public health while limiting the economic and social consequences of over-regulation. The

  3. Biokinetics of indium-111 labeled platelets after cryotherapy of hepatic metastases

    International Nuclear Information System (INIS)

    Alexander, C.; Kirsch, C.-M.; Pistorius, G.; Feifel, G.

    2002-01-01

    Full text: The present investigation was performed to evaluate mean platelet live-span and the proportion of platelet disposal in different organs in patients after hepatic cryotherapy. Seven patients with advanced colorectal cancer and liver metastases were included. Directly before the surgical procedure a blood specimen was drawn and an in vitro labeling of patients platelets with 18 MBq Indium-111 oxime was performed. Reinjection was done intraoperatively just before cryotherapy. Blood specimen were drawn at 1, 2, 3, 24 und 48 h p.i.. Whole-body scintigraphy was acquired on day two alter operation. The evaluation comprised the calculation of mean platelet live-span and of organ activities as percentage of whole-body activity. The local disposal of platelets at the site of cryotherapy ranged from 0 to 35.2 percent, the mean value was 16,2 ± 12,2 percent (mean ± SD). The mean half-time of time-activity curve gave 0.6 to 2.4 days (mean ± SD: 1.6 ± 0.6 d; normal value: 3.5-6 d), the mean platelet life-span was between 2.1 and 5.2 days corresponding to a mean value of 3.4 ± 1.0 days (normal value: 7-11 d). The evaluation of SPECT slices of large liver metastases demonstrated that platelet disposal takes place at the border zone of the metastases just around the necrotic center. We conclude that the enhanced local platelet trapping is a major cause for cryothermia-induced systemic thrombocytopenia. (author)

  4. Biokinetics of different-shaped copper oxide nanoparticles in the freshwater gastropod, Potamopyrgus antipodarum

    DEFF Research Database (Denmark)

    Ramskov, Tina; Croteau, Marie-Noelle; Forbes, Valery E

    2015-01-01

    Sediment is recognized as a major environmental sink for contaminants, including engineered nanoparticles (NPs). Consequently, sediment-living organisms are likely to be exposed to NPs. There is evidence that both accumulation and toxicity of metal NPs to sediment-dwellers increase with decreasing...... particle size, although NP size does not always predict effects. In contrast, not much is known about the influence of particle shape on bioaccumulation and toxicity. Here, we examined the influence of copper oxide (CuO) NP shape (rods, spheres, and platelets) on their bioaccumulation kinetics and toxicity...

  5. Biokinetics of Radiocobalt in the Asteroid Asterias rubens (Echinodermata): Sea Water and Food Exposures

    Energy Technology Data Exchange (ETDEWEB)

    Warnau, Michel; Fowler, Scott W.; Teyssie, Jean-Louis

    1999-01-01

    Uptake and loss of cobalt-57 were investigated in the starfish Asterias rubens, in order to assess its value as a sentinel organism for nearshore radionuclide contamination. Whole-body uptake from sea water was linear over a 32-day exposure period and reached wet weight concentration factor (CF) of 23 {+-} 5. Bioaccumulation of {sup 57}Co was dependent upon body compartment, the aboral part of the body wall concentrating cobalt to the greatest degree (wet weight CF: 77 {+-} 16). After restoration of uncontaminated conditions, radiocobalt was released following an exponential loss kinetics characterized by a biological half-life (T{sub b1/2}) of 27 {+-} 6 day. Dietary radiocobalt (taken up during a short-term feeding for 24 h on radiolabelled mussels) showed a much more rapid turnover time (T{sub b1/2}: 14 {+-} 4 d), suggesting that A. rubens accumulates this radionuclide predominantly from sea water. A. rubens, and more particularly the aboral part of its body wall, would readily reveal the presence of an environmental contamination by radiocobalt and could preserve this information over a period of few months.

  6. Biokinetics of Radiocobalt in the Asteroid Asterias rubens (Echinodermata): Sea Water and Food Exposures

    International Nuclear Information System (INIS)

    Warnau, Michel; Fowler, Scott W.; Teyssie, Jean-Louis

    1999-01-01

    Uptake and loss of cobalt-57 were investigated in the starfish Asterias rubens, in order to assess its value as a sentinel organism for nearshore radionuclide contamination. Whole-body uptake from sea water was linear over a 32-day exposure period and reached wet weight concentration factor (CF) of 23 ± 5. Bioaccumulation of 57 Co was dependent upon body compartment, the aboral part of the body wall concentrating cobalt to the greatest degree (wet weight CF: 77 ± 16). After restoration of uncontaminated conditions, radiocobalt was released following an exponential loss kinetics characterized by a biological half-life (T b1/2 ) of 27 ± 6 day. Dietary radiocobalt (taken up during a short-term feeding for 24 h on radiolabelled mussels) showed a much more rapid turnover time (T b1/2 : 14 ± 4 d), suggesting that A. rubens accumulates this radionuclide predominantly from sea water. A. rubens, and more particularly the aboral part of its body wall, would readily reveal the presence of an environmental contamination by radiocobalt and could preserve this information over a period of few months

  7. Biokinetics of different-shaped copper oxide nanoparticles in the freshwater gastropod, Potamopyrgus antipodarum

    Science.gov (United States)

    Ramskov, Tina; Croteau, Marie-Noele; Forbes, Valery E.; Selck, Henriette

    2015-01-01

    Sediment is recognized as a major environmental sink for contaminants, including engineered nanoparticles (NPs). Consequently, sediment-living organisms are likely to be exposed to NPs. There is evidence that both accumulation and toxicity of metal NPs to sediment-dwellers increase with decreasing particle size, although NP size does not always predict effects. In contrast, not much is known about the influence of particle shape on bioaccumulation and toxicity. Here, we examined the influence of copper oxide (CuO) NP shape (rods, spheres, and platelets) on their bioaccumulation kinetics and toxicity to the sediment-dwelling gastropod, Potamopyrgus antipodarum. The influence of Cu added as CuCl2 (i.e., aqueous Cu treatment) was also examined. Exposure to sediment mixed with aqueous Cu or with different-shaped CuO NPs at an average measured exposure concentration of 207 μg Cu per g dry weight sediment for 14 days did not significantly affect snail mortality. However, growth decreased for snails exposed to sediment amended with CuO NP spheres and platelets. P. antipodarum accumulated Cu from all Cu forms/shapes in significant amounts compared to control snails. In addition, once accumulated, Cu was efficiently retained (i.e., elimination rate constants were generally not significantly different from zero). Consequently, snails are likely to concentrate Cu over time, from both aqueous and NP sources, resulting in a high potential for toxicity.

  8. Nanomaterial translocation - the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs

    DEFF Research Database (Denmark)

    Kermanizadeh, Ali; Balharry, Dominique; Wallin, Håkan

    2015-01-01

    indicates that pulmonary exposure is associated with low (inhalation route-0.00001-1% of total applied dose-24 h) translocation of virtually insoluble NMs such as iridium, carbon black, gold and polystyrene, while slightly higher translocation has been observed for NMs with either slow (e.g. silver, cerium...

  9. Radionuclide Decorporation: Matching the Biokinetics of Actinides by Transdermal Delivery of Pro-chelators

    OpenAIRE

    Zhang, Yong; Sadgrove, Matthew P.; Mumper, Russell J.; Jay, Michael

    2013-01-01

    The threat of nuclear terrorism by the deliberate detonation of a nuclear weapon or radiological dispersion device (“dirty bomb”) has made emergency response planning a priority. The only FDA-approved treatments for contamination with isotopes of the transuranic elements Am, Pu, and Cm are the Ca and Zn salts of diethylenetriaminepentaacetic acid (DTPA). These injectable products are not well suited for use in a mass contamination scenario as they require skilled professionals for their admin...

  10. Activated sludge model (ASM) based modelling of membrane bioreactor (MBR) processes: a critical review with special regard to MBR specificities.

    Science.gov (United States)

    Fenu, A; Guglielmi, G; Jimenez, J; Spèrandio, M; Saroj, D; Lesjean, B; Brepols, C; Thoeye, C; Nopens, I

    2010-08-01

    Membrane bioreactors (MBRs) have been increasingly employed for municipal and industrial wastewater treatment in the last decade. The efforts for modelling of such wastewater treatment systems have always targeted either the biological processes (treatment quality target) as well as the various aspects of engineering (cost effective design and operation). The development of Activated Sludge Models (ASM) was an important evolution in the modelling of Conventional Activated Sludge (CAS) processes and their use is now very well established. However, although they were initially developed to describe CAS processes, they have simply been transferred and applied to MBR processes. Recent studies on MBR biological processes have reported several crucial specificities: medium to very high sludge retention times, high mixed liquor concentration, accumulation of soluble microbial products (SMP) rejected by the membrane filtration step, and high aeration rates for scouring purposes. These aspects raise the question as to what extent the ASM framework is applicable to MBR processes. Several studies highlighting some of the aforementioned issues are scattered through the literature. Hence, through a concise and structured overview of the past developments and current state-of-the-art in biological modelling of MBR, this review explores ASM-based modelling applied to MBR processes. The work aims to synthesize previous studies and differentiates between unmodified and modified applications of ASM to MBR. Particular emphasis is placed on influent fractionation, biokinetics, and soluble microbial products (SMPs)/exo-polymeric substances (EPS) modelling, and suggestions are put forward as to good modelling practice with regard to MBR modelling both for end-users and academia. A last section highlights shortcomings and future needs for improved biological modelling of MBR processes. (c) 2010 Elsevier Ltd. All rights reserved.

  11. Development of derived limits for radiological protection against ionizing radiation based on ICRP-60 recommendations

    International Nuclear Information System (INIS)

    Jang, S. Y.; Lee, B. S.

    1999-01-01

    Derived limits such as the Annual Limit on Intake (ALI), Derived Air Concentration (DAC) and Effluent Concentration Limit (ECL) for radiological protection against ionizing radiation based on ICRP-60 recommendations were calculated using dose limits and committed effective dose coefficients of the basic Safety Standards of IAEA (i.e. safety series 115; BSS-96). Derived limits regarding occupational exposure were derived using methodologies of ICRP-61 and dose limit stated in ICRP -60. ECL in air and water for the control of radioactive discharge into the environment were derived using methodologies of 10 CFR part 20 and dose limit stated in ICRP-60. In order to analyze the impact of implementing derived limits on nuclear facilities, the derived values in this study were compared with those prescribed in 10 CFR part 20 as well as the Maximum Permissible Concentrations (MPC) of Notice No. 98-12 of the Ministry of Science and Technology (MOST). According to the comparison results, ECLs in air and water for the control of radioactive discharge into the environment in this study are shown to have lower values (i.e. more conservative), for most part, than those in Notice No. 98-12. These differences are due to the reduction of dose limit, adoption of a weighting factor for age-dependency in dose coefficients, and application of new respiratory tract model and bio-kinetics model. Especially, for uranium elements (i.e., 235 U, 238 U, etc.), which are governing ones in the nuclear fuel industries, ECLs in water are approximately a magnitude in the order of two lower than those in Notice No. 98-12. These are attributable to the adoption of a weighting factor for age-dependency in dose coefficients, newly recommended dose coefficients for ingestion pathway, and reduction of dose limit. It was found out that the differences in ECLs in water for uranium elements originated mostly from ingestion dose coefficients recommended by BSS-96. (author). 6 refs., 2 tabs., 5 figs

  12. EURADOS coordinated action on research, quality assurance and training of internal dose assessments.

    Science.gov (United States)

    Lopez, M A; Balásházy, I; Bérard, P; Blanchardon, E; Breustedt, B; Broggio, D; Castellani, C M; Franck, D; Giussani, A; Hurtgen, C; James, A C; Klein, W; Kramer, G H; Li, W B; Marsh, J W; Malatova, I; Nosske, D; Oeh, U; Pan, G; Puncher, M; Peixoto Telles, P; Teixoto Telles, P; Schimmelpfeng, J; Vrba, T

    2011-03-01

    EURADOS working group on 'Internal Dosimetry (WG7)' represents a frame to develop activities in the field of internal exposures as coordinated actions on quality assurance (QA), research and training. The main tasks to carry out are the update of the IDEAS Guidelines as a reference document for the internal dosimetry community, the implementation and QA of new ICRP biokinetic models, the assessment of uncertainties related to internal dosimetry models and their application, the development of physiology-based models for biokinetics of radionuclides, stable isotope studies, biokinetic modelling of diethylene triamine pentaacetic acid decorporation therapy and Monte-Carlo applications to in vivo assessment of intakes. The working group is entirely supported by EURADOS; links are established with institutions such as IAEA, US Transuranium and Uranium Registries (USA) and CEA (France) for joint collaboration actions.

  13. Study of the biokinetic behavior of 99mTc-DMSA in renal scintigraphy of pediatric patients

    International Nuclear Information System (INIS)

    Santos, Felipe Simas dos

    2013-01-01

    In Brazil, renal studies with 99m Tc D TPA and 99m Tc-DMSA constitute about 18% of pediatric diagnostic procedures. A retrospective non-randomized study was conducted in 2010, for absolute quantification of kidney activities. In 2010,51 patients underwent renal studies in the Hospital of the Rio de Janeiro State University - HUPE-UERJ/ RJ, Brazil. 19 of them with 9±4 years of age and body mass of 31.8±20.8 kg showed relative uptake of 99m Tc-DMSA between 45% and 55%. Still images (AP, PA and posterior oblique abdomen incidences) were acquired 4 h after intravenous administration of 115.69±42.31 MBq of 99m Tc-DMSA using gamma camera (Siemens E-Cam), LEHR collimator, matrix of 256x256 and 5min imaging. In 2012, 3 patients (9.3±2.1 years, 31.97±10.75 kg) in the previous study were followed in a prospective study. All urinary excretions samples were collected from administration of 99m Tc-DMSA to 6 h after, while simultaneously images were acquired AP and PA abdominal region with Philips model Picker Prism 2000XP. Aliquots of each urine sample were measured in gamma counter shaft GenesysTM Gamma 1 with Nal (TI) detector. For whole body, the biological half-life estimate was 11.0±2.0 h, and the residence time was found to be 5.6±0.4 h while the literature suggests 4.l±0.5 h for age range studied. Residence time for kidney was found to be 0.7±0.4 h, while the literature shows, 3.07 h and 1.4 h for patients with normal and renal pathologies, respectively. This difference may be attributed to the methodology because while the images were taken during the first 6 h, SMITH et aI. (1996) performed images of the kidneys and whole body 30 h after administration of 99mTc D MSA, incorporating the slow term of biological half-life. For liver, it was found the average residence time of 3.0±0.4 min, whereas the literature indicates 20.8 min and 25.1 min, respectively according to SMITH et. ai (1996) and ICRP (1998). The fact that the administered activity was higher than the activity estimated by 3 different criteria is not a single parameter to be considered for the optimization of doses, once for diagnostic image quality it must be ensured. Therefore, the analysis of the quality of the images should be part of the study. It is recommended to include in the study protocol whole body images on the first day and 24 h after administration of 99m Tc-DMSA. To quantify the activity in the whole body, it is recommended to perform the patient attenuation map through an emission image. For organ images, it is recommended to use physical simulator to obtain the calibration factor of the respective body. The acquisition time of the images should follow the estimated time for the biological half-life of 2 terms (fast and slow). (author)

  14. Prostate lymphoscintigraphy for sentinel lymph node identification in canines: reproducibility, uptake, and biokinetics depending on different injection strategies.

    Science.gov (United States)

    Wawroschek, Friedhelm; Wengenmair, Hermann; Senekowitsch-Schmidtke, Reingard; Hamm, Michael; Henke, Julia; Schönberger, Tanja; Hauser, Andrea; Erhardt, Wolf; Harzmann, Rolf

    2003-07-01

    At present there are neither clinical nor experimental data available on the influence of technical details on the quality and reproducibility of prostate lymphoscintigraphy. Six adult fox hounds received repeated transrectal ultrasound guided intraprostatic injections of a technetium 99m labeled nanocolloid to prove the influence of different techniques of injection (one central injection in both prostate lobes vs two peripheral injections in both lobes) on tracer accumulation in sentinel lymph nodes (SLN) and other organs. The reproducibility of the favored technique was examined and in a last step it was subject to scrutiny following a reduction of the injected volume to 1% of the prostate volume. The number of scintigraphically visualized SLN varied between four and seven. They were located in the region of the internal and external iliac vessels, presacrally, paravesically, and directly paraprostatically. In five of six cases, the localization was reproducible both with the central application of an identical volume as well as with the volume reduced central injection. Tracer accumulation of SLNs and other organs varied enormously. We expect that with the combination of both injection techniques, even with the reduced injection volume, an optimized prostate lymphoscintigraphy will be the outcome.

  15. Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs

    NARCIS (Netherlands)

    Notenboom, Sylvia; Weigand, Karl M; Proost, Johannes H; van Lipzig, Marola M H; van de Steeg, Evita; van den Broek, Petra H H; Greupink, Rick; Russel, Frans G M; Groothuis, Geny M M

    2018-01-01

    Drug-induced liver injury (DILI) is a common reason for drug withdrawal from the market. An important cause of DILI is drug-induced cholestasis. One of the major players involved in drug-induced cholestasis is the bile salt efflux pump (BSEP; ABCB11). Inhibition of BSEP by drugs potentially leads to

  16. Biokinetic and dosimetry of {sup 99m}Tc-14F7-monoclonal antibody in patients with breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, Joaquin; Calderon, Carlos; Pimentel, Gilmara; Oliva, Juan P., E-mail: jgg@infomed.sld.cu [Departmento de Medicina Nuclear, Instituto de Oncologia y Radiobiologia, Cidad Habana (Cuba); Casaco, Angel [Division de Ensayos Clinicos, Centro de Inmunologia Molecular, Reparto Siboney, Ciudad Habana (Cuba)

    2008-07-01

    Full text: The 14F7 murine MAb is an IgG1 that binds specifically to GM3(Neu-Gc) ganglioside strongly recognizing the antigen displayed in human breast and melanoma tumors. A preliminary report showed in vivo evidences of presence of GM3(Neu-Gc) ganglioside in human breast primary tumors using 14F7 MAb labelled with {sup 99m}Tc. In this work the pharmacokinetics and biodistribution of {sup 99m}Tc-14F7 MAb in patient with breast cancer were studied. The absorbed dose in normal organ and tumors was also calculated. The patients were selected from a Phase I/II clinical trial which included 14 female patients with cytological diagnose of breast carcinoma in stage II without previous onco-specific treatment. Three groups were conformed: Group I (0.3mg, n=5), Group II (1mg, n=5) and Group III (3mg, n=4). The activity ranged in 1.11 - 1.48GBq (30- 40mCi) was intravenously administered during 1-2min. The {sup 99m}Tc-14F7 plasma clearance was determined by blood sampling at 5, 10, 20, 30min and 1, 2, 4, 8 and 24h after injection. All urine excreted by patients was collected during 24h after injection at intervals of 0-2h, 2-8h and 8-24h. Prior to injection, a transmission scan of head, thorax, abdomen and pelvis was obtained using a {sup 57}Co flood source. Anterior and posterior whole body images were acquired at 30min, 2h, 4h, 8h and 24h after injection using a Gamma Camera (SophyCamera DS7) with pinhole collimator. Static anterior and posterior images were obtained from head, thorax, abdomen, pelvis and lateral images of each breast in pendular position at 2h, 4h, 8h and 24h. Internal absorbed dose calculation was performed according to MIRD formalism using the S values for adult non-pregnant female phantom downloaded from the RADAR website. Self-absorbed tumor dose were calculated assuming those as spheres with uniform distribution of activity. The plasma clearance of radiotracer in all groups shows a monoexponential decay behaviour with biological elimination half time ranged in 15h and 19h. The distribution volume was similar to physiological volume in normal subject. A low urinary excretion was observed. The biodistribution shows a high retention of radiotracer in whole-body. A high uptake and retention was observed in bone marrow, kidneys and liver. The highest absorbed dose per MBq was observed in liver and kidneys. The {sup 99m}Tc-14F7 shows a rapid tumor uptake (<2.5h) with a delayed biological elimination half time (>4.5 days). In most cases, the maximum activity uptake in tumor (<1%/100g of tumor) was observed at 24 hours after injection. The pharmacokinetic data observed for {sup 99m}Tc-14F7 MAb behaves as a monoexponential model showing a slow clearance from plasma and a low urinary excretion. (author)

  17. Biokinetic and dosimetry of 99mTc-14F7-monoclonal antibody in patients with breast cancer

    International Nuclear Information System (INIS)

    Gonzalez, Joaquin; Calderon, Carlos; Pimentel, Gilmara; Oliva, Juan P.; Casaco, Angel

    2008-01-01

    Full text: The 14F7 murine MAb is an IgG1 that binds specifically to GM3(Neu-Gc) ganglioside strongly recognizing the antigen displayed in human breast and melanoma tumors. A preliminary report showed in vivo evidences of presence of GM3(Neu-Gc) ganglioside in human breast primary tumors using 14F7 MAb labelled with 99m Tc. In this work the pharmacokinetics and biodistribution of 99m Tc-14F7 MAb in patient with breast cancer were studied. The absorbed dose in normal organ and tumors was also calculated. The patients were selected from a Phase I/II clinical trial which included 14 female patients with cytological diagnose of breast carcinoma in stage II without previous onco-specific treatment. Three groups were conformed: Group I (0.3mg, n=5), Group II (1mg, n=5) and Group III (3mg, n=4). The activity ranged in 1.11 - 1.48GBq (30- 40mCi) was intravenously administered during 1-2min. The 99m Tc-14F7 plasma clearance was determined by blood sampling at 5, 10, 20, 30min and 1, 2, 4, 8 and 24h after injection. All urine excreted by patients was collected during 24h after injection at intervals of 0-2h, 2-8h and 8-24h. Prior to injection, a transmission scan of head, thorax, abdomen and pelvis was obtained using a 57 Co flood source. Anterior and posterior whole body images were acquired at 30min, 2h, 4h, 8h and 24h after injection using a Gamma Camera (SophyCamera DS7) with pinhole collimator. Static anterior and posterior images were obtained from head, thorax, abdomen, pelvis and lateral images of each breast in pendular position at 2h, 4h, 8h and 24h. Internal absorbed dose calculation was performed according to MIRD formalism using the S values for adult non-pregnant female phantom downloaded from the RADAR website. Self-absorbed tumor dose were calculated assuming those as spheres with uniform distribution of activity. The plasma clearance of radiotracer in all groups shows a monoexponential decay behaviour with biological elimination half time ranged in 15h and 19h. The distribution volume was similar to physiological volume in normal subject. A low urinary excretion was observed. The biodistribution shows a high retention of radiotracer in whole-body. A high uptake and retention was observed in bone marrow, kidneys and liver. The highest absorbed dose per MBq was observed in liver and kidneys. The 99m Tc-14F7 shows a rapid tumor uptake (<2.5h) with a delayed biological elimination half time (>4.5 days). In most cases, the maximum activity uptake in tumor (<1%/100g of tumor) was observed at 24 hours after injection. The pharmacokinetic data observed for 99m Tc-14F7 MAb behaves as a monoexponential model showing a slow clearance from plasma and a low urinary excretion. (author)

  18. Determination of biokinetic coefficients for an adsorption/bio-oxidation process on municipal wastewater in pilot-scale

    Directory of Open Access Journals (Sweden)

    Mostafa Hadei

    2015-01-01

    Conclusions: All coefficients were in the range of activated sludge coefficients that are mentioned in the literature, except μmax and K S of B-stage. However, K S value of B-stage was close to the desired range. Sensitivity analysis showed that μmax and K S have the most influence on effluent substrate concentration (sCOD.

  19. Experimental studies on the biokinetics of Cs-134 and Cd-109 in the blood cockle (Anadara granosa)

    International Nuclear Information System (INIS)

    Norfaizal Mohamed; Nita Salina Abu Bakar; Zal Uyun Wan Mahmood; Nur Hidaya Dmuliany Mohd Sidek; Zaharudin Ahmad

    2010-01-01

    Bioaccumulation and depuration study under controlled laboratory conditions of Cs and Cd in Anadara granosa collected at coastal Kapar, Selangor was carried out using respective radiotracer, Cs-134 and Cd-109. The radioactivity of Cs-134 and Cd-109 were determined using high resolution hyper germanium detector. Our results demonstrate that Cd-109 was accumulated efficiently by this species, except Cs-134. The steady state concentration factor (CF) for accumulation of Cs-134 and Cd-109 from seawater was estimated to be about 5.86 and 51.31, respectively. For the depuration stage, loss kinetics of Cs-134 and Cd-109 was best described by 2-compartment exponential model. Results shown that A. granosa exposed to Cs-134 have a total loss of 69% in compared to 19 % of Cd-109. Results gained in this experiment are a baseline data to evaluate future released of radioactive material from nuclear power programme facilities within this region. (author)

  20. Radiation fields, dosimetry, biokinetics and biophysical models for cancer induction by ionising radiation 1996-1999. Dose reconstruction. Final report

    International Nuclear Information System (INIS)

    Jacob, P.; Aragno, D.; Bailiff, I.K.

    2000-01-01

    The project Dose Reconstruction was conducted within the five work packages: - EPR with teeth, - Chromosome painting (FISH) in lymphocytes, - Luminescence methods, - Modelling, and - Evaluation. (orig.)

  1. Biokinetic Analysis and Metabolic Fate of 2,4-D in 2,4-D-Resistant Soybean (Glycine max).

    Science.gov (United States)

    Skelton, Joshua J; Simpson, David M; Peterson, Mark A; Riechers, Dean E

    2017-07-26

    The Enlist weed control system allows the use of 2,4-D in soybean but slight necrosis in treated leaves may be observed in the field. The objectives of this research were to measure and compare uptake, translocation, and metabolism of 2,4-D in Enlist (E, resistant) and non-AAD-12 transformed (NT, sensitive) soybeans. The adjuvant from the Enlist Duo herbicide formulation (ADJ) increased 2,4-D uptake (36%) and displayed the fastest rate of uptake (U 50 = 0.2 h) among treatments. E soybean demonstrated a faster rate of 2,4-D metabolism (M 50 = 0.2 h) compared to NT soybean, but glyphosate did not affect 2,4-D metabolism. Metabolites of 2,4-D in E soybean were qualitatively different than NT. Applying 2,4-D-ethylhexyl ester instead of 2,4-D choline (a quaternary ammonium salt) eliminated visual injury to E soybean, likely due to the time required for initial de-esterification and bioactivation. Excessive 2,4-D acid concentrations in E soybean resulting from ADJ-increased uptake may significantly contribute to foliar injury.

  2. Excretion of radionuclides in human breast milk after nuclear medicine examinations. Biokinetic and dosimetric data and recommendations on breastfeeding interruption

    Energy Technology Data Exchange (ETDEWEB)

    Liepe, K. [GH Hospital Frankfurt/Oder, Department of Nuclear Medicine, Frankfurt an der Oder (Germany); Becker, A. [GH Hospital Frankfurt/Oder, Department of Internal Medicine, Frankfurt an der Oder (Germany)

    2016-05-15

    Since the 1990s the advantages of breastfeeding have been emphasized and the number of women who nurse their infant has increased significantly. Although women in this population are generally healthy and relatively rarely need radionuclide imaging or radionuclide therapies, the issue of radiation protection of breastfed children arises because of their higher radiosensitivity. Approximately 55 papers on excretion of radionuclides in human breast milk after radionuclide imaging or therapy have been published. Unfortunately, most of them are case reports or include only a small number of cases. In 1955 the first report was published about a breastfeeding woman after radioiodine treatment of thyrotoxicosis. This early study showed a higher concentration of radioiodine in breast milk than in plasma and investigated the risk to the infant, especially to the thyroid gland.

  3. Modeling and monitoring of the acclimatization of conventional activated sludge to a biohydrogen producing culture by biokinetic control

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez-Morales, F.J.; Villasenor, J.; Infantes, D. [University of Castilla-La Mancha, ITQUIMA, Chemical Engineering Department, Avenida Camilo Jose Cela S/N. 13071 Ciudad Real (Spain)

    2010-10-15

    The purpose of this work was to study the acclimatization of activated sludge as it evolved into an acidogenic culture capable of producing volatile fatty acids and hydrogen from glucose. The experiments were conducted in a Sequential Batch Reactor with a pH of 5, a temperature of 35 C and in the absence of oxygen. Biomass, substrate and product concentrations were monitored during the experiment. The presence of aerobic, facultative and acidogenic microorganisms was determined for the initial seed, and their main kinetic and stoichiometric properties were determined. For the acidogenic microorganisms, {mu}{sub max}, b and Y{sub x} increased during the acclimatization process, reaching final values of 0.125 h{sup -1}, 0.025 h{sup -1}, 0.025 g mmol{sup -1}, respectively. However, for the facultative microorganisms, {mu}{sub max} and b decreased, whereas Y{sub x} remained constant during the acclimatization process, reaching final values of 0.032 h{sup -1}, 0.007 h{sup -1}, 0.017 g mmol{sup -1}, respectively. The evolution of the facultative organisms was significantly related to lactic acid production, whereas the evolution of the acidogenic microorganisms was related to hydrogen, acetic acid and butyric acid production. The biomass concentration of each group was estimated by modeling the experimental data. (author)

  4. Experimental and theoretical study of the transport of silver nanoparticles at their prolonged administration into a mammal organism

    Science.gov (United States)

    Antsiferova, A. A.; Buzulukov, Yu. P.; Kashkarov, P. K.; Kovalchuk, M. V.

    2016-11-01

    The transport of silver nanoparticles in the organism of laboratory animals has been investigated. A mathematical model of the biokinetics of prolonged administration of nonmetabolizable and nonaglomerating pharmaceutical preparations is proposed, and its analytical solution is found. Based on the experimental data on the prolonged introduction and excretion of colloidal silver nanoparticles and the numerical approximation of the solutions to the equations for the proposed model, time dependences of the silver mass content in brain and blood are obtained and some other important biokinetic parameters are determined. It is concluded that both chronic1 and subchronic2 peroral application of these nanoparticles as an biologically active additive or antiseptic is potentially dangerous.

  5. Determination and reliability of dose coefficients for radiopharmaceuticals; Ermittlung der Zuverlaessigkeit von Dosiskoeffizienten fuer Radiopharmaka

    Energy Technology Data Exchange (ETDEWEB)

    Spielmann, V.; Li, W.B.; Zankl, M.; Oeh, U.

    2015-11-15

    The dose coefficients used in nuclear medicine for dose calculations of radiopharmaceuticals are based on recommendations by ICRP (International Commission on radiological protection) and the MIRD (Medical Internal Radiation Dose Committee) using mathematical models for the temporal activity distributions in organs and tissues (biokinetic models) and mathematical models of the human body. These models using an idealized human body do not include uncertainty estimations. The research project is aimed to determine the uncertainties and thus the reliability of the dose coefficients for radiopharmaceuticals and to identify the biokinetic and dosimetric parameters that contribute most of the uncertainties.

  6. IDAC-Dose 2.1, an internal dosimetry program for diagnostic nuclear medicine based on the ICRP adult reference voxel phantoms.

    Science.gov (United States)

    Andersson, Martin; Johansson, Lennart; Eckerman, Keith; Mattsson, Sören

    2017-11-03

    To date, the estimated radiation-absorbed dose to organs and tissues in patients undergoing diagnostic examinations in nuclear medicine is derived via calculations based on models of the human body and the biokinetic behaviour of the radiopharmaceutical. An internal dosimetry computer program, IDAC-Dose2.1, was developed based on the International Commission on Radiological Protection (ICRP)-specific absorbed fractions and computational framework of internal dose assessment given for reference adults in ICRP Publication 133. The program uses the radionuclide decay database of ICRP Publication 107 and considers 83 different source regions irradiating 47 target tissues, defining the effective dose as presented in ICRP Publications 60 and 103. The computer program was validated against another ICRP dosimetry program, Dose and Risk Calculation (DCAL), that employs the same computational framework in evaluation of occupational and environmental intakes of radionuclides. IDAC-Dose2.1 has a sub-module for absorbed dose calculations in spherical structures of different volumes and composition; this sub-module is intended for absorbed dose estimates in radiopharmaceutical therapy. For nine specific alpha emitters, the absorbed dose contribution from their decay products is also included in the committed absorbed dose calculations. The absorbed doses and effective dose of 131 I-iodide determined by IDAC-Dose2.1 were validated against the dosimetry program DCAL, showing identical results. IDAC-Dose2.1 was used to calculate absorbed doses for intravenously administered 18 F-FDG and orally administered 99m Tc-pertechnetate and 131 I-iodide, three frequently used radiopharmaceuticals. Using the tissue weighting factors from ICRP Publication 103, the effective dose per administered activity was estimated to be 0.016 mSv/MBq for 18 F-FDG, 0.014 mSv/MBq for 99m Tc-pertechnetate, and 16 mSv/MBq for 131 I-iodide. The internal dosimetry program IDAC-Dose2.1 was developed and

  7. Uptake kinetics and biodistribution of 14C-d-luciferin - a radiolabeled substrate for the firefly luciferase catalyzed bioluminescence reaction: impact on bioluminescence based reporter gene imaging

    International Nuclear Information System (INIS)

    Berger, Frank; Bhaumik, Srabani

    2008-01-01

    Firefly luciferase catalyzes the oxidative decarboxylation of d-luciferin to oxyluciferin in the presence of cofactors, producing bioluminescence. This reaction is used in optical bioluminescence-based molecular imaging approaches to detect the expression of the firefly luciferase reporter gene. Biokinetics and distribution of the substrate most likely have a significant impact on levels of light signal and therefore need to be investigated. Benzene ring 14 C(U)-labeled d-luciferin was utilized. Cell uptake and efflux assays, murine biodistribution, autoradiography and CCD-camera based optical bioluminescence imaging were carried out to examine the in vitro and in vivo characteristics of the tracer in cell culture and in living mice respectively. Radiolabeled and unlabeled d-luciferin revealed comparable levels of light emission when incubated with equivalent amounts of the firefly luciferase enzyme. Cell uptake assays in pCMV-luciferase-transfected cells showed slow trapping of the tracer and relatively low uptake values (up to 22.9-fold higher in firefly luciferase gene-transfected vs. nontransfected cells, p=0.0002). Biodistribution studies in living mice after tail-vein injection of 14 C-d-luciferin demonstrated inhomogeneous tracer distribution with early predominant high radioactivity levels in kidneys (10.6% injected dose [ID]/g) and liver (11.9% ID/g), followed at later time points by the bladder (up to 81.3% ID/g) and small intestine (6.5% ID/g), reflecting the elimination routes of the tracer. Kinetics and uptake levels profoundly differed when using alternate injection routes (intravenous versus intraperitoneal). No clear trapping of 14 C-d-luciferin in firefly luciferase-expressing tissues could be observed in vivo. The data obtained with 14 C-d-luciferin provide insights into the dynamics of d-luciferin cell uptake, intracellular accumulation, and efflux. Results of the biodistribution and autoradiographic studies should be useful for optimizing and

  8. A practical guideline for the release of patients treated by I-131 based on Monte Carlo dose calculations for family members

    International Nuclear Information System (INIS)

    Han, Eun Young; Lee, Choonsik; Mcguire, Lynn; Bolch, Wesley E

    2014-01-01

    We recently published effective doses per time-integrated activity (mSv MBq −1  s −1 ) for paediatric and adult family members exposed to an adult patient released from hospital following I-131 therapy. In the present study, we intend to provide medical physicists with a methodology to estimate family member effective dose in daily clinical practice because the duration of post-radiation precautions for the patient–family member exposure scenario has not been explicitly delineated based on the effective dose. Four different exposure scenarios are considered in this study including (1) a patient and a family member standing face to face, (2) a patient and a family member lying side by side, (3) an adult female patient holding a newborn child to her chest and (4) a one-year-old child standing on the lap of an adult female patient following her I-131 therapy. The results of this study suggest that an adult female hyperthyroidism (HT) patient who was administered with 740 MBq should keep a distance of 100 cm from a 15-year-old child for six days and the same distance from other adults for seven days. The HT female patient should avoid holding a newborn against her chest for at least 16 days following hospital discharge, and a female patient treated with 5550 MBq for differentiated thyroid cancer should not hold her newborn child for at least 15 days following hospital discharge. This study also gives dose coefficients allowing one to predict age-specific effective doses to family members given the measured dose rate (mSv h −1 ) of the patient. In conclusion, effective dose-based patient release criteria with a modified NRC two-component model provide a site medical physicist with less restrictive and age-specific radiation precaution guidance as they fully consider a patient’s iodine biokinetics and photon attenuation within both the patient and the exposed family members. (note)

  9. Polonium-210 and other radionuclides in terrestrial, freshwater and brackish environments Results from the NKS project GAPRAD (Filling knowledge gaps in radiation protection methodologies for non-human biota)

    International Nuclear Information System (INIS)

    Gjelsvik, R.; Brown, J.; Holm, E.; Roos, P.; Saxen, R.; Outola, I.

    2012-01-01

    The background and rationale to filling knowledge gaps in radiation protection methodologies for biota are presented. Concentrations of Po-210 and Pb-210 are reported for biota sampled in Dovrefjell, Norway and selected lake and brackish ecosystems in Finland. Furthermore, details in relation to Po-210 uptake and biokinetics in humans based on experimental studies are recounted. (Author)

  10. Polonium-210 and other radionuclides in terrestrial, freshwater and brackish environments Results from the NKS project GAPRAD (Filling knowledge gaps in radiation protection methodologies for non-human biota)

    Energy Technology Data Exchange (ETDEWEB)

    Gjelsvik, R.; Brown, J.; Holm, E.; Roos, P.; Saxen, R.; Outola, I.

    2012-01-15

    The background and rationale to filling knowledge gaps in radiation protection methodologies for biota are presented. Concentrations of Po-210 and Pb-210 are reported for biota sampled in Dovrefjell, Norway and selected lake and brackish ecosystems in Finland. Furthermore, details in relation to Po-210 uptake and biokinetics in humans based on experimental studies are recounted. (Author)

  11. Binary mixtures of mercury/ selenium, and lead/selenium

    African Journals Online (AJOL)

    Physiologically-based biokinetic models have been developed for predicting simultaneously the Absorption, Distribution, Metabolism and Elimination (ADME) properties of lead (Pb) and selenium (Se), and mercury (Hg) and selenium in a number of target tissues of humans. This was done for three population groups, ...

  12. Touch BASE

    CERN Multimedia

    Antonella Del Rosso

    2015-01-01

    In a recent Nature article (see here), the BASE collaboration reported the most precise comparison of the charge-to-mass ratio of the proton to its antimatter equivalent, the antiproton. This result is just the beginning and many more challenges lie ahead.   CERN's AD Hall, where the BASE experiment is set-up. The Baryon Antibaryon Symmetry Experiment (BASE) was approved in June 2013 and was ready to take data in August 2014. During these 14 months, the BASE collaboration worked hard to set up its four cryogenic Penning traps, which are the heart of the whole experiment. As their name indicates, these magnetic devices are used to trap antiparticles – antiprotons coming from the Antiproton Decelerator – and particles of matter – negative hydrogen ions produced in the system by interaction with a degrader that slows the antiprotons down, allowing scientists to perform their measurements. “We had very little time to set up the wh...

  13. Web based foundry knowledge base

    Directory of Open Access Journals (Sweden)

    A. Stawowy

    2009-01-01

    Full Text Available The main assumptions and functions of proposed Foundry Knowledge Base (FKB are presented in this paper. FKB is a framework forinformation exchange of casting products and manufacturing methods. We use CMS (Content Management System to develope andmaintain our web-based system. The CastML – XML dialect developed by authors for description of casting products and processes – isused as a tool for information interchange between ours and outside systems, while SQL is used to store and edit knowledge rules and alsoto solve the basic selection problems in the rule-based module. Besides the standard functions (companies data, news, events, forums and media kit, our website contains a number of nonstandard functions; the intelligent search module based on expert system is the main advantage of our solution. FKB is to be a social portal which content will be developed by foundry community.

  14. Fragmentation based

    Directory of Open Access Journals (Sweden)

    Shashank Srivastava

    2014-01-01

    Gaining the understanding of mobile agent architecture and the security concerns, in this paper, we proposed a security protocol which addresses security with mitigated computational cost. The protocol is a combination of self decryption, co-operation and obfuscation technique. To circumvent the risk of malicious code execution in attacking environment, we have proposed fragmentation based encryption technique. Our encryption technique suits the general mobile agent size and provides hard and thorny obfuscation increasing attacker’s challenge on the same plane providing better performance with respect to computational cost as compared to existing AES encryption.

  15. In vivo biokinetic and metabolic characterization of the {sup 68}Ga-labelled α5β1-selective peptidomimetic FR366

    Energy Technology Data Exchange (ETDEWEB)

    D' Alessandria, Calogero; Pohle, Karolin; Schwaiger, Markus [Technische Universitaet Muenchen, Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Muenchen (Germany); Rechenmacher, Florian; Neubauer, Stefanie; Kessler, Horst [Technische Universitaet Muenchen, Institute for Advanced Study (IAS) and Center of Integrated Protein Science (CIPSM), Department Chemie, Garching (Germany); Notni, Johannes; Wester, Hans-Juergen [Technische Universitaet Muenchen, Lehrstuhl fuer Pharmazeutische Radiochemie, Garching (Germany); Beer, Ambros J. [Technische Universitaet Muenchen, Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Muenchen (Germany); Ulm University, Department of Nuclear Medicine, Ulm (Germany)

    2016-05-15

    Integrins are transmembrane receptors responsible for cell-cell adhesion and cell-extracellular matrix binding and play an important role in angiogenesis and tumour metastasis. For this reason, integrins are increasingly used as targets for molecular imaging. Up to now interest has mostly been focused on the integrin subtype αvβ3. However, targeting of other subtypes such as the integrin α5β1 is also of high interest due to its central role in colonization of metastatic cells, resistance of tumour cells to chemotherapy and ionizing radiation, and tumour aggressiveness. Recently, a highly active antagonist ligand (2,2'-(7-(1-carboxy-4-((6-((3-(4-(((S)-1-carboxy-2-(2- (3-guanidinobenzamido)acet amido)ethyl)carbamoyl)-3,5-dimethylphenoxy) propyl)amino)-6-oxohexyl)amino)-4-oxo butyl)-1,4,7-triazonane-1,4-diyl)diacetic acid, FR366) for the integrin subtype α5β1 with high selectivity versus αvβ3, has been developed and tested successfully in preliminary in vitro and in vivo experiments. Here, we present our results of an investigation of the use of {sup 68}Ga-labelled α5β1 ligand in PET imaging. The free α5β1 peptidomimetic ligand was functionalized with a spacer (6-aminohexanoic acid) and the bifunctional chelator 1-((1,3-dicarboxy)propyl) -4,7-(carboxymethyl)-1,4,7-triazacyclononane (NODAGA) to yield FR366 and labelled with {sup 68}Ga. To confirm selective in vivo targeting of α5β1, female BALB/c nude mice xenografted with α5β1-expressing RKO cells in the right shoulder and α5β1/αvβ3-expressing M21 cells in the left shoulder were subjected to PET/CT scans and biodistribution experiments. Specificity of tracer uptake was proven by blocking studies. Metabolic stability of the injected tracer was measured in urine and in plasma. MicroPET/CT scans with radiolabelled FR366 showed a good tumour-to-normal tissue ratio with low uptake in the liver (0.32 ± 0.14 %ID/g) and good retention of {sup 68}Ga-NODAGA-FR366 in the tumour (0.71 ± 0.20 %ID/g and 0.40 ± 0.12 %ID/g for RKO and M21 tumours, respectively, at 90 min after injection). Biodistribution experiments showed uptake in the α5β1-expressing RKO tumour of 1.05 ± 0.23 %ID/g at 90 min after injection. Specificity of tracer uptake was demonstrated by injection of 5 mg/kg unlabelled ligand 10 min prior to tracer injection, resulting in a 67 % reduction in uptake in the RKO tumour. The tracer was found to be metabolically stable in urine and plasma 30 min after injection. Our results show that PET imaging of α5β1 expression with the {sup 68}Ga-labelled α5β1-specific ligand is feasible with good image quality. Thus, FR366 is a promising new tool for investigating the role of α5β1 in angiogenesis and the influence of this integrin subtype on cancer aggressiveness and metastatic potential. (orig.)

  16. Radiation fields, dosimetry, biokinetics and biophysical models for cancer induction by ionising radiation 1996-1999. Biophysical models for the induction of cancer by radiation. Final report

    International Nuclear Information System (INIS)

    Paretzke, H.G.; Ballarini, F.; Brugmans, M.

    2000-01-01

    The overall project is organised into seven work packages. WP1 concentrates on the development of mechanistic, quantitative models for radiation oncogenesis using selected data sets from radiation epidemiology and from experimental animal studies. WP2 concentrates on the development of mechanistic, mathematical models for the induction of chromosome aberrations. WP3 develops mechanistic models for radiation mutagenesis, particularly using the HPRT-mutation as a paradigm. WP4 will develop mechanistic models for damage and repair of DNA, and compare these with experimentally derived data. WP5 concentrates on the improvement of our knowledge on the chemical reaction pathways of initial radiation chemical species in particular those that migrate to react with the DNA and on their simulation in track structure codes. WP6 models by track structure simulation codes the production of initial physical and chemical species, within DNA, water and other components of mammalian cells, in the tracks of charged particles following the physical processes of energy transfer, migration, absorption, and decay of excited states. WP7 concentrates on the determination of the start spectra of those tracks considered in WP6 for different impinging radiation fields and different irradiated biological objects. (orig.)

  17. Biokinetics of cadmium, selenium, and zinc in freshwater alga Scenedesmus obliquus under different phosphorus and nitrogen conditions and metal transfer to Daphnia magna

    International Nuclear Information System (INIS)

    Yu Riqing; Wang Wenxiong

    2004-01-01

    The uptake of Cd, Se(IV) and Zn by the freshwater alga Scenedesmus obliquus and the subsequent transfer and release budget in Daphnia magna were investigated under different nutrient additions and cell incubation conditions. An increase in ambient phosphate concentrations from 0.5 μmol l -1 to 50 μmol l -1 significantly increased the intracellular accumulation of Cd (by 18x) and Zn (by 5x), but decreased the accumulation of Se (by 126x) in the alga. The percentage of these metals distributing in the intracellular pool of algae also increased substantially with increasing ambient P concentrations. Nitrate addition from 5.0 to 200 μmol l -1 did not influence the uptake of any of the three metals, although a significant decrease in the intracellular Se distribution was observed. Radiolabeled algae under different nutrient manipulations (semi-continuous culture, starvation, and P-pulse treatments) were used to measure trophic transfer assimilation efficiency (AE) in Daphnia. When the algal cells were grown in a semi-continuous culture, starved for N and P, or were treated with P-pulse, the AEs of Cd and Zn were generally independent of the nutritional conditions, but the Se AE was significantly affected by different P levels. The efflux rate constants, determined during 10 d depuration following 7 days of dietary uptake, decreased significantly for Cd and Zn, but were relatively constant for Se with increasing P concentration. N-addition caused no effect on the metal efflux rate constants. P- or N-additions did not influence the release budget (including molting, neonates, excretion and feces) for all three elements in Daphnia. Our study indicated that phosphate enrichment may substantially increase metal uptake in green alga S. obliquus. Responses of trophic transfer in Daphnia to nutrient enrichment were metal specific. P-enrichment can possibly lead to considerable decrease on Se transfer from algae to zooplankton. - Phosphorous enrichment influences metal uptake by algae, but not transfer to a zooplankton grazer

  18. Experimental study of Americium-241 biokinetics in Homarus Gammarus lobster. Analysis of the accumulation and detoxication mechanisms at the sub-cellular level

    International Nuclear Information System (INIS)

    Paquet, F.

    1991-12-01

    The Americium 241 radioelement accumulation and elimination rate and mechanisms in the lobster organism have been experimentally studied; incorporation and detoxification capacities of each organ are evaluated. The existence of various biological compartments is shown; the major role of the digestive gland in accumulation of the radioelement, its distribution towards the various organs, and its resorption is comprehensively described, with an analysis at the subcellular and molecular levels. 401 p., 65 fig., 43 tab., 428 ref

  19. An experimental study of americium-241 biokinetics in the Lobster Homarus Gammarus. Analysis of the accumulation/storage and detoxification processes at the subcellular level

    International Nuclear Information System (INIS)

    Paquet, F.

    1993-01-01

    An experimental study of americium-241 kinetics has been conducted in the lobster Homarus gammmarus. The investigations were conducted at all the levels from the whole body to the subcellular and molecular levels. The animals were contaminated by a single or chronic ingestion of 241 Am labelled mussels. Assessments of accumulation, elimination and distribution of the radionuclide were established on organisms kept in the laboratory; they made it possible to demonstrate the importance of the digestive gland in the radionuclide transfer pathways. The preliminary results led to structural then ultrastructural investigations of the digestive gland in association with radioautographic studies and cellular extractions methods. Four cellular types were demonstrated, only two of them being implied in the radionuclide retention, the former being responsible for americium intake and the latter for its long-term retention. By means of biochemical techniques, subcellular accumulation was studied and the organelles implied in the nuclide retention were specified. Finally, a method of cellular nuclei dissociation was developed; it made it possible to analyse the molecular nature of americium ligands and to demonstrate the function of the protein nuclear matrix in the nuclide retention

  20. Optimization of GATE simulations for whole-body planar scintigraphic acquisitions using the XCAT male phantom with177Lu-DOTATATE biokinetics in a Siemens Symbia T2.

    Science.gov (United States)

    Costa, G C A; Bonifácio, D A B; Sarrut, D; Cajgfinger, T; Bardiès, M

    2017-10-01

    Simulations of planar whole body acquisitions in therapeutic procedures are often extensively time-consuming and therefore rarely used. However, optimising tools and variance reduction techniques can be employed to overcome this problem. In this paper, a variety of features available in GATE are explored and their capabilities to reduce simulation time are evaluated. For this purpose, the male XCAT phantom was used as a virtual patient with 177 Lu-DOTATATE pharmacokinetic for whole body planar acquisition simulations in a Siemens Symbia T2 model. Activity distribution was divided into 8 compartments that were simulated separately. GATE optimization techniques included reducing the amount of time spent in both voxel and detector tracking. Some acceleration techniques led to a decrease of CPU-time by a factor of 167, while image statistics were kept constant. In that context, the simulation of therapeutic procedure imaging would still require 46days on a single CPU, but this could be reduced to hours on a dedicated cluster. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  1. The estimation of daily intake and organ content of Cs, I, Sr, Th and U in Indian population: Application to the study of their biokinetics

    International Nuclear Information System (INIS)

    Dang, H.S.; Jaiswal, D.D.; Pullat, V.R.; Parameswaran, M.; Krishnamony, S.

    1998-01-01

    The analytical methods involving both instrumental and radiochemical neutron activation techniques (INAA and RNAA) are being standardised for the determination of the elements Cs, I, Sr, Th and U in various kinds of biological samples. The sampling method proposed to be adopted for the estimation of the daily dietary intake, of the above elements is described. Also reported in this paper are the preliminary results on the concentrations of these elements in the food ingredients which form important components of the diet of Indian population. (author)

  2. Biokinetic studies and scintigraphic imaging of human pancreatic carcinoma xenografts with iodine 131-labeled F(ab')2-fragments of monoclonal antibodies

    International Nuclear Information System (INIS)

    Senekowitsch, R.; Moellenstaedt, S.; Kriegel, H.; Baum, R.P.; Maul, F.D.; Hoer, G.; Wenisch, H.J.C.

    1985-01-01

    Biodistribution and tumor uptake of I-131 labeled F(ab') 2 -fragments of monoclonal antibodies to CA 125, CA 19-9 and CEA were investigated in nuce mice with human pancreatic carcinoma xenografts. To assess the immunological specificity of these antibody fragments their tumor uptake was compared with that of unspecific IgG F(ab') 2 . Additionally serum levels of CA 125 and CA 19-9 were determined in tumor bearing mice by radioimmunoassay and the expression of CA 125 and CA 19-9 in pancreatic carcinoma was demonstrated by immunhistochemicals studies. The rapid blood clearance of the antibody fragments leads to increasing tumor-to-blood ratios with time after injection for all antibody fragments. The highest ratios were found for OC 125 at all time points p.i., with mean values of 9.6 at 48 h p.i. and 11.8 at 96 h p.i. On scintigraphic images tumors with a weight of 100 mg could be localized between 24 and 48 h after injection of iodinated OC 125 F(ab') 2 . The serum levels of CA 125 and CA 19-9 were elevated only in some animals and no correlation between the antigen serum levels and the antigen expression in the tumor shown by immunhistochemical staining could be determined. (orig.) [de

  3. Foundation: Transforming data bases into knowledge bases

    Science.gov (United States)

    Purves, R. B.; Carnes, James R.; Cutts, Dannie E.

    1987-01-01

    One approach to transforming information stored in relational data bases into knowledge based representations and back again is described. This system, called Foundation, allows knowledge bases to take advantage of vast amounts of pre-existing data. A benefit of this approach is inspection, and even population, of data bases through an intelligent knowledge-based front-end.

  4. Underbody Blast Models of TBI Caused by Hyper-Acceleration and Secondary Head Impact

    Science.gov (United States)

    2016-02-01

    pixels in the selected area. Final PCI helmet selection was based on several criteria including elastic modulus, load transfer char - acteristics and the...Biokinetics of Impacts (IRCOBI), San Diego, California, October 17–19, 1983. 17Hong, Y., and R. Bartlett. Routledge handbook of bio - mechanics and human...Kochanek PM, Dixon CE, Shellington DK, Shin SS, Bayır H, Jackson EK, Kagan VE, Yan HQ, Swauger PV, Parks SA, et al. Screening of bio - chemical and molecular

  5. Energy Metabolism and Human Dosimetry of Tritium

    International Nuclear Information System (INIS)

    Galeriu, D.; Takeda, H.; Melintescu, A.; Trivedi, A.

    2005-01-01

    In the frame of current revision of human dosimetry of 14 C and tritium, undertaken by the International Commission of Radiological Protection, we propose a novel approach based on energy metabolism and a simple biokinetic model for the dynamics of dietary intake (organic 14 C, tritiated water and Organically Bound Tritium-OBT). The model predicts increased doses for HTO and OBT comparing to ICRP recommendations, supporting recent findings

  6. Age-specific models for evaluating dose and risk from internal exposures to radionuclides: Report of current work of the Metabolism and Dosimetry Research Group, July 1, 1985-June 30, 1987

    Energy Technology Data Exchange (ETDEWEB)

    Leggett, R.W.; Warren, B.P. (eds.)

    1987-09-01

    A projection of the health risk to a population internally exposed to a radionuclide requires explicit or implicit use of demographic, biokinetic, dosimetric, and dose-response models. Exposure guidelines have been based on models for a reference adult with a fixed life span. In this report, we describe recent efforts to develop a comprehensive methodology for estimation of radiogenic risk to individuals and to heterogeneous populations. Emphasis is on age-dependent biokinetics and dosimetry for internal emitters, but consideration also is given to conversion of age-specific doses to estimates of risk using realistic, site-specific demographic models and best available age-specific dose-response functions. We discuss how the methods described here may also improve estimates for the reference adult usually considered in radiation protection. 159 refs.

  7. Age-specific models for evaluating dose and risk from internal exposures to radionuclides: Report of current work of the Metabolism and Dosimetry Research Group, July 1, 1985-June 30, 1987

    International Nuclear Information System (INIS)

    Leggett, R.W.; Warren, B.P.

    1987-09-01

    A projection of the health risk to a population internally exposed to a radionuclide requires explicit or implicit use of demographic, biokinetic, dosimetric, and dose-response models. Exposure guidelines have been based on models for a reference adult with a fixed life span. In this report, we describe recent efforts to develop a comprehensive methodology for estimation of radiogenic risk to individuals and to heterogeneous populations. Emphasis is on age-dependent biokinetics and dosimetry for internal emitters, but consideration also is given to conversion of age-specific doses to estimates of risk using realistic, site-specific demographic models and best available age-specific dose-response functions. We discuss how the methods described here may also improve estimates for the reference adult usually considered in radiation protection. 159 refs

  8. Mathematical Modeling of Hollow-Fiber Membrane System in Biological Wastewater Treatment

    Directory of Open Access Journals (Sweden)

    Jian PENG

    2006-02-01

    Full Text Available A set of mathematical models were derived based on the bio-kinetics and material balance principles to describe the performance of membrane system in this research. A synthetic wastewater and a meat packing wastewater were processed through a lab-scale membrane bioreactor system to generate experimental data for calibration and verification of the derived models. For the synthetic wastewater treatment, a high and stable Total Organic Carbon (TOC removal was achieved with volumetric organic loading from 0.2 to 24.2 kg TOC/m3ƒ(d. It was found that the derived system models fit the experimental data well. The bio-kinetic coefficients of k, Ks, Y and kd in the models were found to be 0.16 d-1, 1.0 mg/L, 1.75 mg Mixed Liquor Volatile Suspended Solids (MLVSS/mg TOC and 0.11 d-1, respectively. For the meat packing wastewater treatment, the bio-kinetic coefficients of k, Ks, Y and kd were found to be 0.48 d-1, 56.3 mg/L, 0.53 mg MLVSS/mg COD and 0.04 d-1, respectively. F/M ratio of 0.08 was found to be the proper operating condition for the system. Based on the proposed system models, the optimum MLSS concentration and F/M ratio can be computed to yield minimum cost of a membrane bioreactor system without excess biomass production.

  9. A physiological systems model for iodine for use in radiation protection

    International Nuclear Information System (INIS)

    Leggett, Richard Wayne

    2010-01-01

    This paper summarizes the biokinetic database for iodine in the human body and proposes a biokinetic model for use in dose assessments for radioiodine. The model unifies and extends existing physiological systems models describing three subsystems of the iodine cycle in the body: circulating (extrathyroidal) inorganic iodide; thyroidal iodine (trapping and organic binding of iodide, and synthesis, storage, and secretion of thyroid hormones); and extrathyroidal organic iodine. Thyroidal uptake of iodide is described as a function of daily stable iodine intake and requirements for thyroid hormones. Baseline parameter values are developed for adults with typical iodine intakes and hormone requirements. Estimated thyroid doses derived from the baseline parameter values and reference thyroid weights are higher than values predicted by the current model of the International Commission on Radiological Protection (ICRP) for adults for intake of iodine isotopes with half-lives up to a few hours but consistent with ICRP predictions for longer-lived isotopes. For nearly all iodine isotopes, the proposed model yields order-of-magnitude differences from the ICRP's current iodine model for adults for stomach wall, salivary gland, and kidneys. Dose estimates for intravenously injected 131I-labeled thyroid hormones based on the present model differ substantially from current ICRP values for adult patients for some organs, including the thyroid. Subsequent studies will address age-specific biokinetics of iodine, reduction of doses from radioiodine due to thyroid blocking, and effects of dietary iodine levels and thyroid hormone requirements on thyroid doses from radioiodine.

  10. A physiological systems model for iodine for use in radiation protection

    Energy Technology Data Exchange (ETDEWEB)

    Leggett, Richard Wayne [ORNL

    2010-01-01

    This paper summarizes the biokinetic database for iodine in the human body and proposes a biokinetic model for use in dose assessments for radioiodine. The model unifies and extends existing physiological systems models describing three subsystems of the iodine cycle in the body: circulating (extrathyroidal) inorganic iodide; thyroidal iodine (trapping and organic binding of iodide, and synthesis, storage, and secretion of thyroid hormones); and extrathyroidal organic iodine. Thyroidal uptake of iodide is described as a function of daily stable iodine intake and requirements for thyroid hormones. Baseline parameter values are developed for adults with typical iodine intakes and hormone requirements. Estimated thyroid doses derived from the baseline parameter values and reference thyroid weights are higher than values predicted by the current model of the International Commission on Radiological Protection (ICRP) for adults for intake of iodine isotopes with half-lives up to a few hours but consistent with ICRP predictions for longer-lived isotopes. For nearly all iodine isotopes, the proposed model yields order-of-magnitude differences from the ICRP s current iodine model for adults for stomach wall, salivary gland, and kidneys. Dose estimates for intravenously injected 131I-labeled thyroid hormones based on the present model differ substantially from current ICRP values for adult patients for some organs, including the thyroid. Subsequent studies will address age-specific biokinetics of iodine, reduction of doses from radioiodine due to thyroid blocking, and effects of dietary iodine levels and thyroid hormone requirements on thyroid doses from radioiodine.

  11. The physics data base

    International Nuclear Information System (INIS)

    Gault, F.D.

    1984-01-01

    The physics data base is introduced along with its associated data base management system. The emphasis is on data and their use and a classification of data and of data bases is developed to distinguish compilation organizations. The characteristics of these organizations are examined briefly and the long term consequences of the physics data base discussed. (orig.)

  12. Solid Base Catalysis

    CERN Document Server

    Ono, Yoshio

    2011-01-01

    The importance of solid base catalysts has come to be recognized for their environmentally benign qualities, and much significant progress has been made over the past two decades in catalytic materials and solid base-catalyzed reactions. The book is focused on the solid base. Because of the advantages over liquid bases, the use of solid base catalysts in organic synthesis is expanding. Solid bases are easier to dispose than liquid bases, separation and recovery of products, catalysts and solvents are less difficult, and they are non-corrosive. Furthermore, base-catalyzed reactions can be performed without using solvents and even in the gas phase, opening up more possibilities for discovering novel reaction systems. Using numerous examples, the present volume describes the remarkable role solid base catalysis can play, given the ever increasing worldwide importance of "green" chemistry. The reader will obtain an overall view of solid base catalysis and gain insight into the versatility of the reactions to whic...

  13. Mobile Inquiry Based Learning

    NARCIS (Netherlands)

    Specht, Marcus

    2012-01-01

    Specht, M. (2012, 8 November). Mobile Inquiry Based Learning. Presentation given at the Workshop "Mobile inquiry-based learning" at the Mobile Learning Day 2012 at the Fernuniversität Hagen, Hagen, Germany.

  14. VectorBase

    Data.gov (United States)

    U.S. Department of Health & Human Services — VectorBase is a Bioinformatics Resource Center for invertebrate vectors. It is one of four Bioinformatics Resource Centers funded by NIAID to provide web-based...

  15. The ground based plan

    International Nuclear Information System (INIS)

    1989-01-01

    The paper presents a report of ''The Ground Based Plan'' of the United Kingdom Science and Engineering Research Council. The ground based plan is a plan for research in astronomy and planetary science by ground based techniques. The contents of the report contains a description of:- the scientific objectives and technical requirements (the basis for the Plan), the present organisation and funding for the ground based programme, the Plan, the main scientific features and the further objectives of the Plan. (U.K.)

  16. Stolen Base Physics

    Science.gov (United States)

    Kagan, David

    2013-01-01

    Few plays in baseball are as consistently close and exciting as the stolen base. While there are several studies of sprinting, the art of base stealing is much more nuanced. This article describes the motion of the base-stealing runner using a very basic kinematic model. The model will be compared to some data from a Major League game. The…

  17. Value-based pricing

    OpenAIRE

    Netseva-Porcheva Tatyana

    2010-01-01

    The main aim of the paper is to present the value-based pricing. Therefore, the comparison between two approaches of pricing is made - cost-based pricing and value-based pricing. The 'Price sensitively meter' is presented. The other topic of the paper is the perceived value - meaning of the perceived value, the components of perceived value, the determination of perceived value and the increasing of perceived value. In addition, the best company strategies in matrix 'value-cost' are outlined. .

  18. Soy-based polyols

    Science.gov (United States)

    Suppes, Galen; Lozada, Zueica; Lubguban, Arnold

    2013-06-25

    The invention provides processes for preparing soy-based oligomeric polyols or substituted oligomeric polyols, as well as urethane bioelasteromers comprising the oligomeric polyols or substituted oligomeric polyols.

  19. XML-BASED REPRESENTATION

    Energy Technology Data Exchange (ETDEWEB)

    R. KELSEY

    2001-02-01

    For focused applications with limited user and use application communities, XML can be the right choice for representation. It is easy to use, maintain, and extend and enjoys wide support in commercial and research sectors. When the knowledge and information to be represented is object-based and use of that knowledge and information is a high priority, then XML-based representation should be considered. This paper discusses some of the issues involved in using XML-based representation and presents an example application that successfully uses an XML-based representation.

  20. Imagery Data Base Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Imagery Data Base Facility supports AFRL and other government organizations by providing imagery interpretation and analysis to users for data selection, imagery...

  1. Synthetic Base Fluids

    Science.gov (United States)

    Brown, M.; Fotheringham, J. D.; Hoyes, T. J.; Mortier, R. M.; Orszulik, S. T.; Randles, S. J.; Stroud, P. M.

    The chemical nature and technology of the main synthetic lubricant base fluids is described, covering polyalphaolefins, alkylated aromatics, gas-to-liquid (GTL) base fluids, polybutenes, aliphatic diesters, polyolesters, polyalkylene glycols or PAGs and phosphate esters.Other synthetic lubricant base oils such as the silicones, borate esters, perfluoroethers and polyphenylene ethers are considered to have restricted applications due to either high cost or performance limitations and are not considered here.Each of the main synthetic base fluids is described for their chemical and physical properties, manufacture and production, their chemistry, key properties, applications and their implications when used in the environment.

  2. Strengths-based Learning

    DEFF Research Database (Denmark)

    Ledertoug, Mette Marie

    Strength-based learning - Children͛s Character Strengths as Means to their Learning Potential͛ is a Ph.D.-project aiming to create a strength-based mindset in school settings and at the same time introducing strength-based interventions as specific tools to improve both learning and well......-being. The Ph.D.-project in Strength-based learning took place in a Danish school with 750 pupils age 6-16 and a similar school was functioning as a control group. The presentation will focus on both the aware-explore-apply processes and the practical implications for the schools involved, and on measurable...

  3. Monitoring Knowledge Base (MKB)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Monitoring Knowledge Base (MKB) is a compilation of emissions measurement and monitoring techniques associated with air pollution control devices, industrial...

  4. Case-based reasoning

    CERN Document Server

    Kolodner, Janet

    1993-01-01

    Case-based reasoning is one of the fastest growing areas in the field of knowledge-based systems and this book, authored by a leader in the field, is the first comprehensive text on the subject. Case-based reasoning systems are systems that store information about situations in their memory. As new problems arise, similar situations are searched out to help solve these problems. Problems are understood and inferences are made by finding the closest cases in memory, comparing and contrasting the problem with those cases, making inferences based on those comparisons, and asking questions whe

  5. Secure base stations

    NARCIS (Netherlands)

    Bosch, Peter; Brusilovsky, Alec; McLellan, Rae; Mullender, Sape J.; Polakos, Paul

    2009-01-01

    With the introduction of the third generation (3G) Universal Mobile Telecommunications System (UMTS) base station router (BSR) and fourth generation (4G) base stations, such as the 3rd Generation Partnership Project (3GPP) Long Term Evolution (LTE) Evolved Node B (eNB), it has become important to

  6. Mutually unbiased bases

    Indian Academy of Sciences (India)

    Abstract. After a brief review of the notion of a full set of mutually unbiased bases in an N- dimensional Hilbert space, we summarize the work of Wootters and Fields (W K Wootters and. B C Fields, Ann. Phys. 191, 363 (1989)) which gives an explicit construction for such bases for the case N pr, where p is a prime. Further, we ...

  7. Game-Based Teaching

    DEFF Research Database (Denmark)

    Hanghøj, Thorkild

    2013-01-01

    This chapter outlines theoretical and empirical perspectives on how Game-Based Teaching can be integrated within the context of formal schooling. Initially, this is done by describing game scenarios as models for possible actions that need to be translated into curricular knowledge practices...... approaches to game-based teaching, which may or may not correspond with the pedagogical models of particular games....

  8. Home-based care

    African Journals Online (AJOL)

    Mrs. Patience Edoho Samson-Akpan

    PLWHA. The recommendation was that home based care should be encouraged and given priority by stake holders in the management of PLWHA. KEY WORDS: home-based care, quality of life, basic nursing care, psychosocial care. INTRODUCTION. HIV/AIDS is a chronic progressive disease which threatens the quality ...

  9. Diffusion Based Photon Mapping

    DEFF Research Database (Denmark)

    Schjøth, Lars; Olsen, Ole Fogh; Sporring, Jon

    2006-01-01

    . To address this problem we introduce a novel photon mapping algorithm based on nonlinear anisotropic diffusion. Our algorithm adapts according to the structure of the photon map such that smoothing occurs along edges and structures and not across. In this way we preserve the important illumination features......, while eliminating noise. We call our method diffusion based photon mapping....

  10. Skull base tumours

    Energy Technology Data Exchange (ETDEWEB)

    Borges, Alexandra [Instituto Portugues de Oncologia Francisco Gentil, Servico de Radiologia, Rua Professor Lima Basto, 1093 Lisboa Codex (Portugal)], E-mail: borgesalexandra@clix.pt

    2008-06-15

    With the advances of cross-sectional imaging radiologists gained an increasing responsibility in the management of patients with skull base pathology. As this anatomic area is hidden to clinical exam, surgeons and radiation oncologists have to rely on imaging studies to plan the most adequate treatment. To fulfil these endeavour radiologists need to be knowledgeable about skull base anatomy, about the main treatment options available, their indications and contra-indications and needs to be aware of the wide gamut of pathologies seen in this anatomic region. This article will provide a radiologists' friendly approach to the central skull base and will review the most common central skull base tumours and tumours intrinsic to the bony skull base.

  11. Context Based Wikipedia Linking

    Science.gov (United States)

    Granitzer, Michael; Seifert, Christin; Zechner, Mario

    Automatically linking Wikipedia pages can be done either content based by exploiting word similarities or structure based by exploiting characteristics of the link graph. Our approach focuses on a content based strategy by detecting Wikipedia titles as link candidates and selecting the most relevant ones as links. The relevance calculation is based on the context, i.e. the surrounding text of a link candidate. Our goal was to evaluate the influence of the link-context on selecting relevant links and determining a links best-entry-point. Results show, that a whole Wikipedia page provides the best context for resolving link and that straight forward inverse document frequency based scoring of anchor texts achieves around 4% less Mean Average Precision on the provided data set.

  12. Evidence-based radiography

    International Nuclear Information System (INIS)

    Hafslund, Bjorg; Clare, Judith; Graverholt, Birgitte; Wammen Nortvedt, Monica

    2008-01-01

    Evidence-based practice (EBP) offers the integration of the best research evidence with clinical knowledge and expertise and patient values. EBP is a well known term in health care. This paper discusses the implementation of EBP into radiography and introduces the term evidence-based radiography. Evidence-based radiography is radiography informed and based on the combination of clinical expertise and the best available research-based evidence, patient preferences and resources available. In Norway, EBP in radiography is being debated and radiographers are discussing the challenges of implementing EBP in both academic and clinical practice. This discussion paper explains why EBP needs to be a basis for a radiography curriculum and a part of radiographers' practice. We argue that Norwegian radiographers must increase participation in research and developing practice within their specific radiographic domain

  13. QuickBase

    CERN Document Server

    Conner, Nancy

    2007-01-01

    Ready to put Intuit's QuickBase to work? Our new Missing Manual shows you how to capture, modify, share, and manage data and documents with this web-based data-sharing program quickly and easily. No longer do you have to coordinate your team through a blizzard of emails or play frustrating games of "guess which document is the right one."QuickBase saves your organization time and money, letting you manage and share the information that makes your business tick: sales figures, project timelines, drafts of documents, purchase or work requests--whatever information you need to keep business flowi

  14. Equipment fragility data base

    International Nuclear Information System (INIS)

    Cover, L.E.

    1982-03-01

    Part of the effort of the Seismic Safety Margins Research Program (SSMRP) has been directed at generating a fragility data base for equipment used in control and safety systems in commercial nuclear power plants. Component fragility data exist in various forms, depending on their content, intended use, and level of reduction. Th data are stored in a relational data base on the LLNL CDC 7600 computers; this provides easy accessibility for LLNL computer users. This report describes the present structure of the data base and presents its contents through the use of tables

  15. Value-based pricing

    Directory of Open Access Journals (Sweden)

    Netseva-Porcheva Tatyana

    2010-01-01

    Full Text Available The main aim of the paper is to present the value-based pricing. Therefore, the comparison between two approaches of pricing is made - cost-based pricing and value-based pricing. The 'Price sensitively meter' is presented. The other topic of the paper is the perceived value - meaning of the perceived value, the components of perceived value, the determination of perceived value and the increasing of perceived value. In addition, the best company strategies in matrix 'value-cost' are outlined. .

  16. Design-Based Research

    DEFF Research Database (Denmark)

    Gynther, Karsten; Christensen, Ove; Petersen, Trine Brun

    2012-01-01

    I denne artikel introduceres Design Based Research for første gang på dansk i et videnskabeligt tidsskrift. Artiklen præsenterer de grundlæggende antagelser, som ligger til grund for Design Based Research-traditionen, og artiklen diskuterer de principper, som ligger til grund for gennemførelse af...... et DBR-forskningsprojekt. Med udgangspunkt i forsknings- og udviklingsprojektet ELYK: E-læring, Yderområder og Klyngedannelse, præsenteres den innovationsmodel, som projektet har udviklet med udgangspunkt i Design Based Research traditionen. ELYKs DBR innovationsmodel har vist sig effektiv i forhold...

  17. Nature-based integration

    DEFF Research Database (Denmark)

    Pitkänen, Kati; Oratuomi, Joose; Hellgren, Daniela

    Increased attention to, and careful planning of the integration of migrants into Nordic societies is ever more important. Nature based integration is a new solution to respond to this need. This report presents the results of a Nordic survey and workshop and illustrates current practices of nature...... based integration by case study descriptions from Denmark, Sweden Norway and Finland. Across Nordic countries several practical projects and initiatives have been launched to promote the benefits of nature in integration and there is also growing academic interest in the topic. Nordic countries have...... the potential of becoming real forerunners in nature based integration even at the global scale....

  18. Cheboygan Vessel Base

    Data.gov (United States)

    Federal Laboratory Consortium — Cheboygan Vessel Base (CVB), located in Cheboygan, Michigan, is a field station of the USGS Great Lakes Science Center (GLSC). CVB was established by congressional...

  19. Biomimetics: nature based innovation

    National Research Council Canada - National Science Library

    Bar-Cohen, Yoseph

    2012-01-01

    "Based on the concept that nature offers numerous sources of inspiration for inventions related to mechanisms, materials, processes, and algorithms, this book covers the topic of biomimetics and the inspired innovation...

  20. Kelomehele preemia Baseli festivalil

    Index Scriptorium Estoniae

    2000-01-01

    Baselis festivalil "VIPER - International Festival for Film Video and New Media" tunnistati parimaks CD-ROMiks Gustav Deutschi/Anna Schimeki "Odysee today", netiprojektiks itaallaste "01.ORG", äramärkimispreemia - Raivo Kelomehe "Videoweaver"

  1. Hanscom Air Force Base

    Data.gov (United States)

    Federal Laboratory Consortium — MIT Lincoln Laboratory occupies 75 acres (20 acres of which are MIT property) on the eastern perimeter of Hanscom Air Force Base, which is at the nexus of Lexington,...

  2. Network-Based Effectiveness

    National Research Council Canada - National Science Library

    Friman, Henrik

    2006-01-01

    ... (extended from Leavitt, 1965). This text identifies aspects of network-based effectiveness that can benefit from a better understanding of leadership and management development of people, procedures, technology, and organizations...

  3. Evidence based practice

    DEFF Research Database (Denmark)

    Hjørland, Birger

    2011-01-01

    Evidence-based practice (EBP) is an influential interdisciplinary movement that originated in medicine as evidence-based medicine (EBM) about 1992. EBP is of considerable interest to library and information science (LIS) because it focuses on a thorough documentation of the basis for the decision...... making that is established in research as well as an optimization of every link in documentation and search processes. EBP is based on the philosophical doctrine of empiricism and, therefore, it is subject to the criticism that has been raised against empiricism. The main criticism of EBP...... is that practitioners lose their autonomy, that the understanding of theory and of underlying mechanisms is weakened, and that the concept of evidence is too narrow in the empiricist tradition. In this article, it is suggested that we should speak of “research-based practice” rather than EBP, because this term is open...

  4. WormBase

    Data.gov (United States)

    U.S. Department of Health & Human Services — WormBase is an international consortium of biologists and computer scientists dedicated to providing the research community with accurate, current, accessible...

  5. Loyalty Based Investment

    OpenAIRE

    Pei-Hsuan Lee; Ching-Wen Wang

    2010-01-01

    This study investigates the loyalty-based investment behavior in Taiwan. The link between team associations and loyalty has been examined to understand the characteristics of loyalty-based investors. The results revealed that both behavioral loyalty and attitudinal loyalty have significant positive effects on fans' investment intentions. Moreover, both attributes and benefits are significantly and positively related to either aspect of loyalty. In specific, behavioral loyalty has a higher inf...

  6. Game-based telerehabilitation.

    Science.gov (United States)

    Lange, B; Flynn, Sheryl M; Rizzo, A A

    2009-03-01

    This article summarizes the recent accomplishments and current challenges facing game-based virtual reality (VR) telerehabilitation. Specifically this article addresses accomplishments relative to realistic practice scenarios, part to whole practice, objective measurement of performance and progress, motivation, low cost, interaction devices and game design. Furthermore, a description of the current challenges facing game based telerehabilitation including the packaging, internet capabilities and access, data management, technical support, privacy protection, seizures, distance trials, scientific scrutiny and support from insurance companies.

  7. REST based mobile applications

    Science.gov (United States)

    Rambow, Mark; Preuss, Thomas; Berdux, Jörg; Conrad, Marc

    2008-02-01

    Simplicity is the major advantage of REST based webservices. Whereas SOAP is widespread in complex, security sensitive business-to-business aplications, REST is widely used for mashups and end-user centric applicatons. In that context we give an overview of REST and compare it to SOAP. Furthermore we apply the GeoDrawing application as an example for REST based mobile applications and emphasize on pros and cons for the use of REST in mobile application scenarios.

  8. Participatory design based research

    DEFF Research Database (Denmark)

    Dau, Susanne; Falk, Lars; Jensen, Louise Bach

    This poster reveal how participatory design based research by the use of a CoED inspired creative process can be used for designing solutions to problems regarding students study activities outside campus.......This poster reveal how participatory design based research by the use of a CoED inspired creative process can be used for designing solutions to problems regarding students study activities outside campus....

  9. Knowledge Based Strategy

    OpenAIRE

    Nicolescu, Ovidiu

    2006-01-01

    The paper is focused on the essential of knowledge-based strategy taking into consideration the theoretical and practical development during the last 10 years and especially knowledge revolution. It demonstrates the specificity of the company knowledgebased strategies and their necesity. More than this it presents essential elements regarding how to elaborate and to implement a knowledge based strategy starting from well know research in the field.

  10. Evidence-Based Development

    DEFF Research Database (Denmark)

    Hertzum, Morten; Simonsen, Jesper

    2004-01-01

    Systems development is replete with projects that represent substantial resource investments but result in systems that fail to meet users’ needs. Evidence-based development is an emerging idea intended to provide means for managing customer-vendor relationships and working systematically toward...... and electronic patient records for diabetes patients, this paper reports research in progress regarding the prospects and pitfalls of evidence-based development....

  11. [Endonasal skull base endoscopy].

    Science.gov (United States)

    Simal-Julián, Juan Antonio; Miranda-Lloret, Pablo; Pancucci, Giovanni; Evangelista-Zamora, Rocío; Pérez-Borredá, Pedro; Sanromán-Álvarez, Pablo; Perez-de-Sanromán, Laila; Botella-Asunción, Carlos

    2013-01-01

    The endoscopic endonasal techniques used in skull base surgery have evolved greatly in recent years. Our study objective was to perform a qualitative systematic review of the likewise systematic reviews in published English language literature, to examine the evidence and conclusions reached in these studies comparing transcranial and endoscopic approaches in skull base surgery. We searched the references on the MEDLINE and EMBASE electronic databases selecting the systematic reviews, meta-analyses and evidence based medicine reviews on skull based pathologies published from January 2000 until January 2013. We focused on endoscopic impact and on microsurgical and endoscopic technique comparisons. Full endoscopic endonasal approaches achieved gross total removal rates of craniopharyngiomas and chordomas higher than those for transcranial approaches. In anterior skull base meningiomas, complete resections were more frequently achieved after transcranial approaches, with a trend in favour of endoscopy with respect to visual prognosis. Endoscopic endonasal approaches minimised the postoperative complications after the treatment of cerebrospinal fluid (CSF) leaks, encephaloceles, meningoceles, craniopharyngiomas and chordomas, with the exception of postoperative CSF leaks. Randomized multicenter studies are necessary to resolve the controversy over endoscopic and microsurgical approaches in skull base surgery. Copyright © 2013 Sociedad Española de Neurocirugía. Published by Elsevier España. All rights reserved.

  12. LDEF materials data bases

    Science.gov (United States)

    Funk, Joan G.; Strickland, John W.; Davis, John M.

    1993-01-01

    The Long Duration Exposure Facility (LDEF) and the accompanying experiments were composed of and contained a wide variety of materials representing the largest collection of materials flown in low Earth orbit (LEO) and retrieved for ground based analysis to date. The results and implications of the mechanical, thermal, optical, and electrical data from these materials are the foundation on which future LEO space missions will be built. The LDEF Materials Special Investigation Group (MSIG) has been charged with establishing and developing data bases to document these materials and their performance to assure not only that the data are archived for future generations but also that the data are available to the spacecraft user community in an easily accessed, user-friendly form. This paper discusses the format and content of the three data bases developed or being developed to accomplish this task. The hardware and software requirements for each of these three data bases are discussed along with current availability of the data bases. This paper also serves as a user's guide to the MAPTIS LDEF Materials Data Base.

  13. Swarm-based medicine.

    Science.gov (United States)

    Putora, Paul Martin; Oldenburg, Jan

    2013-09-19

    Occasionally, medical decisions have to be taken in the absence of evidence-based guidelines. Other sources can be drawn upon to fill in the gaps, including experience and intuition. Authorities or experts, with their knowledge and experience, may provide further input--known as "eminence-based medicine". Due to the Internet and digital media, interactions among physicians now take place at a higher rate than ever before. With the rising number of interconnected individuals and their communication capabilities, the medical community is obtaining the properties of a swarm. The way individual physicians act depends on other physicians; medical societies act based on their members. Swarm behavior might facilitate the generation and distribution of knowledge as an unconscious process. As such, "swarm-based medicine" may add a further source of information to the classical approaches of evidence- and eminence-based medicine. How to integrate swarm-based medicine into practice is left to the individual physician, but even this decision will be influenced by the swarm.

  14. Estimation of Radiation Doses in the Marshall Islands Based on Whole Body Counting of Cesium-137 (137Cs) and Plutonium Urinalysis

    Energy Technology Data Exchange (ETDEWEB)

    Daniels, J; Hickman, D; Kehl, S; Hamilton, T

    2007-06-11

    measurement. The amount of {sup 137}Cs detected is often reported in activity units of kilo-Becquerel (kBq), where 1 kBq equals 1000 Bq and 1 Bq = 1 nuclear transformation per second (t s{sup -1}). [However, in the United States the Curie (Ci) continues to be used as the unit of radioactivity; where 1 Ci = 3.7 x 10{sup 10} Bq.] The detection of {sup 239}Pu and {sup 240}Pu in bioassay (urine) samples indicates the presence of internally deposited (systemic) plutonium in the body. Urine samples that are collected in the Marshall Islands from volunteers participating in the RSMP are transported to LLNL, where measurements for {sup 239+240}Pu are performed using a state-of-the-art technology based on Accelerator Mass Spectrometry (AMS) (Hamilton et al., 2004, 2007; Brown et al., 2004). The urinary excretion of plutonium by RSMP volunteers is usually described in activity units, expressed as micro-Becquerel ({micro}Bq) of {sup 239+240}Pu (i.e., representing the sum of the {sup 239}Pu and {sup 240}Pu activity) excreted (lost) per day (d{sup -1}), where 1 {micro}Bq d{sup -1} = 10{sup -6} Bq d{sup -1} and 1 Bq = 1 t s{sup -1}. The systemic burden of plutonium is then estimated from biokinetic relationships as described by the International Commission on Radiological Protection (e.g., see ICRP, 1990). In general, nuclear transformations are accompanied by the emission of energy and/or particles in the form of gamma rays ({gamma}), beta particles ({beta}), and/or alpha particles ({alpha}). Tissues in the human body may adsorb these emissions, where there is a potential for any deposited energy to cause biological damage. The general term used to quantify the extent of any radiation exposure is referred to as the dose. The equivalent dose is defined by the average absorbed dose in an organ or tissue weighted by the average quality factor for the type and energy of the emission causing the dose. The effective dose equivalent (EDE; as applied to the whole body), is the sum of the average

  15. Paper based electronics platform

    KAUST Repository

    Nassar, Joanna Mohammad

    2017-07-20

    A flexible and non-functionalized low cost paper-based electronic system platform fabricated from common paper, such as paper based sensors, and methods of producing paper based sensors, and methods of sensing using the paper based sensors are provided. A method of producing a paper based sensor can include the steps of: a) providing a conventional paper product to serve as a substrate for the sensor or as an active material for the sensor or both, the paper product not further treated or functionalized; and b) applying a sensing element to the paper substrate, the sensing element selected from the group consisting of a conductive material, the conductive material providing contacts and interconnects, sensitive material film that exhibits sensitivity to pH levels, a compressible and/or porous material disposed between a pair of opposed conductive elements, or a combination of two of more said sensing elements. The method of sensing can further include measuring, using the sensing element, a change in resistance, a change in voltage, a change in current, a change in capacitance, or a combination of any two or more thereof.

  16. Cantilever Based Mass Sensing

    DEFF Research Database (Denmark)

    Dohn, Søren

    2007-01-01

    suitable for a portable device and to investigate the possibility of enhancing the functionality and sensitivity of cantilever based mass sensors. A readout method based on the hard contact between the cantilever and a biased electrode placed in close proximity to the cantilever is proposed. The viability...... the mass and position of a particle attached to a cantilever to the resonant frequency. It is shown theoretical possible to find the mass and position of a particle by measurements of the resonant frequency of several bending modes. In the measurements the sensitivity of the cantilever based mass sensor...... is improved when operated at higher bending modes. By measuring the resonant frequency of several bending modes both the mass and position of an attached gold bead are determined....

  17. Problem Based Learning

    DEFF Research Database (Denmark)

    de Graaff, Erik; Guerra, Aida

    Problem-Based Learning (PBL) is an innovative method to organize the learning process in such a way that the students actively engage in finding answers by themselves. During the past 40 years PBL has evolved and diversified resulting in a multitude in variations in models and practices. However......, the key principles remain the same everywhere. Graaff & Kolmos (2003) identify the main PBL principles as follows: 1. Problem orientation 2. Project organization through teams or group work 3. Participant-directed 4. Experiental learning 5. Activity-based learning 6. Interdisciplinary learning and 7...... in Engineering Education. In answer to the requests for visits the Aalborg Centre for Problem Based Learning in Engineering Science and Sustainability under the auspices of UNESCO (UCPBL) a two days programme for visitors is offered two times a year. The workshop is an introduction workshop to the Aalborg PBL...

  18. Location-based Scheduling

    DEFF Research Database (Denmark)

    Andersson, Niclas; Christensen, Knud

    the predominant scheduling method since it was introduced in the late 1950s. Over the years, CPM has proven to be a very powerful technique for planning, scheduling and controlling projects, which among other things is indicated by the development of a large number of CPM-based software applications available...... on the market. However, CPM is primarily an activity based method that takes the activity as the unit of focus and there is criticism raised, specifically in the case of construction projects, on the method for deficient management of construction work and continuous flow of resources. To seek solutions...... to the identified limitations of the CPM method, an alternative planning and scheduling methodology that includes locations is tested. Location-based Scheduling (LBS) implies a shift in focus, from primarily the activities to the flow of work through the various locations of the project, i.e. the building. LBS uses...

  19. Skull Base Anatomy.

    Science.gov (United States)

    Patel, Chirag R; Fernandez-Miranda, Juan C; Wang, Wei-Hsin; Wang, Eric W

    2016-02-01

    The anatomy of the skull base is complex with multiple neurovascular structures in a small space. Understanding all of the intricate relationships begins with understanding the anatomy of the sphenoid bone. The cavernous sinus contains the carotid artery and some of its branches; cranial nerves III, IV, VI, and V1; and transmits venous blood from multiple sources. The anterior skull base extends to the frontal sinus and is important to understand for sinus surgery and sinonasal malignancies. The clivus protects the brainstem and posterior cranial fossa. A thorough appreciation of the anatomy of these various areas allows for endoscopic endonasal approaches to the skull base. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Mutually unbiased unitary bases

    Science.gov (United States)

    Shaari, Jesni Shamsul; Nasir, Rinie N. M.; Mancini, Stefano

    2016-11-01

    We consider the notion of unitary transformations forming bases for subspaces of M (d ,C ) such that the square of the Hilbert-Schmidt inner product of matrices from the differing bases is a constant. Moving from the qubit case, we construct the maximal number of such bases for the four- and two-dimensional subspaces while proving the nonexistence of such a construction for the three-dimensional case. Extending this to higher dimensions, we commit to such a construct for the case of qutrits and provide evidence for the existence of such unitaries for prime dimensional quantum systems. Focusing on the qubit case, we show that the average fidelity for estimating any such transformation is equal to the case for estimating a completely unknown unitary from SU(2 ) . This is then followed by a quick application for such unitaries in a quantum cryptographic setup.

  1. On multivariate Wilson bases

    DEFF Research Database (Denmark)

    Bownik, Marcin; Jakobsen, Mads Sielemann; Lemvig, Jakob

    2017-01-01

    A Wilson system is a collection of finite linear combinations of time frequency shifts of a square integrable function. In this paper we give an account of the construction of bimodular Wilson bases in higher dimensions from Gabor frames of redundancy two.......A Wilson system is a collection of finite linear combinations of time frequency shifts of a square integrable function. In this paper we give an account of the construction of bimodular Wilson bases in higher dimensions from Gabor frames of redundancy two....

  2. Inkjet-based micromanufacturing

    CERN Document Server

    Korvink, Jan G; Shin, Dong-Youn; Brand, Oliver; Fedder, Gary K; Hierold, Christofer; Tabata, Osamu

    2012-01-01

    Inkjet-based Micromanufacturing Inkjet technology goes way beyond putting ink on paper: it enables simpler, faster and more reliable manufacturing processes in the fields of micro- and nanotechnology. Modern inkjet heads are per se precision instruments that deposit droplets of fluids on a variety of surfaces in programmable, repeating patterns, allowing, after suitable modifications and adaptations, the manufacturing of devices such as thin-film transistors, polymer-based displays and photovoltaic elements. Moreover, inkjet technology facilitates the large-scale production of flexible RFID tr

  3. Scenario-based strategizing

    DEFF Research Database (Denmark)

    Lehr, Thomas; Lorenz, Ullrich; Willert, Markus

    2017-01-01

    on behavioural strategy as a theoretical lens, we design a yardstick to study the impact of scenario-based strategizing. We then describe our approach, which includes developing scenarios and alternative strategies separately and supporting the strategy selection through an integrated assessment of the goal......-based efficacy and robustness. To facilitate the colla- borative strategizing in teams, we propose a matrix with robustness and efficacy as the two axes, which we call the Parmenides Matrix. We assess the impact of the novel approach by applying it in two cases, at a govern- mental agency (German Environmental...... Ministry) and a firm affected by disruptive change (Bosch, leading global supplier of technology and solutions)....

  4. Iron-based superconductivity

    CERN Document Server

    Johnson, Peter D; Yin, Wei-Guo

    2015-01-01

    This volume presents an in-depth review of experimental and theoretical studies on the newly discovered Fe-based superconductors.  Following the Introduction, which places iron-based superconductors in the context of other unconventional superconductors, the book is divided into three sections covering sample growth, experimental characterization, and theoretical understanding.  To understand the complex structure-property relationships of these materials, results from a wide range of experimental techniques and theoretical approaches are described that probe the electronic and magnetic proper

  5. Identity-based encryption

    CERN Document Server

    Chatterjee, Sanjit

    2011-01-01

    Identity Based Encryption (IBE) is a type of public key encryption and has been intensely researched in the past decade. Identity-Based Encryption summarizes the available research for IBE and the main ideas that would enable users to pursue further work in this area. This book will also cover a brief background on Elliptic Curves and Pairings, security against chosen Cipher text Attacks, standards and more. Advanced-level students in computer science and mathematics who specialize in cryptology, and the general community of researchers in the area of cryptology and data security will find Ide

  6. Video-based rendering

    CERN Document Server

    Magnor, Marcus A

    2005-01-01

    Driven by consumer-market applications that enjoy steadily increasing economic importance, graphics hardware and rendering algorithms are a central focus of computer graphics research. Video-based rendering is an approach that aims to overcome the current bottleneck in the time-consuming modeling process and has applications in areas such as computer games, special effects, and interactive TV. This book offers an in-depth introduction to video-based rendering, a rapidly developing new interdisciplinary topic employing techniques from computer graphics, computer vision, and telecommunication en

  7. Evidence-Based Development

    DEFF Research Database (Denmark)

    Hertzum, Morten; Simonsen, Jesper

    2004-01-01

    Systems development is replete with projects that represent substantial resource investments but result in systems that fail to meet users’ needs. Evidence-based development is an emerging idea intended to provide means for managing customer-vendor relationships and working systematically toward...... meeting customer needs. We are suggesting that the effects of the use of a system should play a prominent role in the contractual definition of IT projects and that contract fulfilment should be determined on the basis of evidence of these effects. Based on two ongoing studies of home-care management...

  8. Scenario-based strategizing

    DEFF Research Database (Denmark)

    Lehr, Thomas; Lorenz, Ullrich; Willert, Markus

    2017-01-01

    For over 40 years, scenarios have been promoted as a key technique for forming strategies in uncertain en- vironments. However, many challenges remain. In this article, we discuss a novel approach designed to increase the applicability of scenario-based strategizing in top management teams. Drawing...... on behavioural strategy as a theoretical lens, we design a yardstick to study the impact of scenario-based strategizing. We then describe our approach, which includes developing scenarios and alternative strategies separately and supporting the strategy selection through an integrated assessment of the goal...... Ministry) and a firm affected by disruptive change (Bosch, leading global supplier of technology and solutions)....

  9. Molecule-based magnets

    Indian Academy of Sciences (India)

    The design of molecule-based magnets has also been extended to the design of poly-functional molecular magnets, such as those exhibiting second-order optical nonlinearity, liquid crystallinity, or chirality simultaneously with long-range magnetic order. Solubility, low density and biocompatibility are attractive features of ...

  10. Project-Based Science

    Science.gov (United States)

    Krajcik, Joe

    2015-01-01

    Project-based science is an exciting way to teach science that aligns with the "Next Generation Science Standards" ("NGSS"). By focusing on core ideas along with practices and crosscutting concepts, classrooms become learning environments where teachers and students engage in science by designing and carrying out…

  11. based gel polymer electrolytes

    Indian Academy of Sciences (India)

    Bull. Mater. Sci., Vol. 29, No. 7, December 2006, pp. 673–678. © Indian Academy of Sciences. 673. Investigation on poly (vinylidene fluoride) based gel polymer electrolytes ... (Alamgir and Abraham 1993; Sukeshini et al 1996; Ra- jendran and Uma ... Yang et al 1996; Ramesh and Arof 2001) and such elec- trolytes exhibit ...

  12. Wrought cobalt- base superalloys

    Science.gov (United States)

    Klarstrom, D. L.

    1993-08-01

    Wrought cobalt-base superalloys are used extensively in gas turbine engines because of their excellent high-temperature creep and fatigue strengths and resistance to hot corrosion attack. In addition, the unique character of the oxide scales that form on some of the alloys provides outstanding resistance to high-temperature sliding wear. This article provides a review of the evolutionary development of wrought cobalt-base alloys in terms of alloy design and physical metallurgy. The topics include solid-so-lution strengthening, carbide precipitation characteristics, and attempts to introduce age hardening. The use of PHACOMP to enhance thermal stability characteristics and the incorporation of rare-earth ele-ments to improve oxidation resistance is also reviewed and discussed. The further development of cobalt-base superalloys has been severely hampered by past political events, which have accentuated the strategic vulnerability of cobalt as a base or as an alloying element. Consequently, alternative alloys have been developed that use little or no cobalt. One such alternative, Haynes® 230TMalloy, is discussed briefly.

  13. Refractive index based measurements

    DEFF Research Database (Denmark)

    2014-01-01

    In a method for performing a refractive index based measurement of a property of a fluid such as chemical composition or temperature by observing an apparent angular shift in an interference fringe pattern produced by back or forward scattering interferometry, ambiguities in the measurement caused...

  14. Refractive index based measurements

    DEFF Research Database (Denmark)

    2014-01-01

    In a method for performing a refractive index based measurement of a property of a fluid such as chemical composition or temperature, a chirp in the local spatial frequency of interference fringes of an interference pattern is reduced by mathematical manipulation of the recorded light intensity...

  15. Refractive index based measurements

    DEFF Research Database (Denmark)

    2014-01-01

    A refractive index based measurement of a property of a fluid is measured in an apparatus comprising a variable wavelength coherent light source (16), a sample chamber (12), a wavelength controller (24), a light sensor (20), a data recorder (26) and a computation apparatus (28), by - directing...

  16. Community-Based Care

    Science.gov (United States)

    ... Health A to Z › Community-Based Care Font size A A A Print Share Glossary Basic Facts & Information Other Resources Caregiving How To's Tools & Tips Latest Research Getting More Help Related Topics Assisted Living Home Care Nursing Homes Join our e-newsletter! ...

  17. Mutually unbiased bases

    Indian Academy of Sciences (India)

    Mutually unbiased bases play an important role in quantum cryptography [2] and in the optimal determination of the density operator of an ensemble [3,4]. A density operator ρ in N-dimensions depends on N2 1 real quantities. With the help of MUB's, any such density operator can be encoded, in an optimal way, in terms of ...

  18. Lunar Base Sitting

    Science.gov (United States)

    Staehle, Robert L.; Burke, James D.; Snyder, Gerald C.; Dowling, Richard; Spudis, Paul D.

    1993-01-01

    Speculation with regard to a permanent lunar base has been with us since Robert Goddard was working on the first liquid-fueled rockets in the 1920's. With the infusion of data from the Apollo Moon flights, a once speculative area of space exploration has become an exciting possibility. A Moon base is not only a very real possibility, but is probably a critical element in the continuation of our piloted space program. This article, originally drafted by World Space Foundation volunteers in conjuction with various academic and research groups, examines some of the strategies involved in selecting an appropriate site for such a lunar base. Site selection involves a number of complex variables, including raw materials for possible rocket propellant generation, hot an cold cycles, view of the sky (for astronomical considerations, among others), geological makeup of the region, and more. This article summarizes the key base siting considerations and suggests some alternatives. Availability of specific resources, including energy and certain minerals, is critical to success.

  19. Problem-based learning

    NARCIS (Netherlands)

    Loyens, Sofie; Kirschner, Paul A.; Paas, Fred

    2010-01-01

    Loyens, S. M. M., Kirschner, P. A., & Paas, F. (2011). Problem-based learning. In S. Graham (Editor-in-Chief), A. Bus, S. Major, & L. Swanson (Associate Editors), APA educational psychology handbook: Vol. 3. Application to learning and teaching (pp. 403-425). Washington, DC: American Psychological

  20. ISFET based enzyme sensors

    NARCIS (Netherlands)

    van der Schoot, Bart H.; Bergveld, Piet

    1987-01-01

    This paper reviews the results that have been reported on ISFET based enzyme sensors. The most important improvement that results from the application of ISFETs instead of glass membrane electrodes is in the method of fabrication. Problems with regard to the pH dependence of the response and the

  1. Internet based benchmarking

    DEFF Research Database (Denmark)

    Bogetoft, Peter; Nielsen, Kurt

    2005-01-01

    We discuss the design of interactive, internet based benchmarking using parametric (statistical) as well as nonparametric (DEA) models. The user receives benchmarks and improvement potentials. The user is also given the possibility to search different efficiency frontiers and hereby to explore...

  2. Financing Competency Based Programs.

    Science.gov (United States)

    Daniel, Annette

    Literature on the background, causes, and current prevalence of competency based programs is synthesized in this report. According to one analysis of the actual and probable costs of minimum competency testing, estimated costs for test development, test administration, bureaucratic structures, and remedial programs for students who cannot pass the…

  3. Diffusion Based Photon Mapping

    DEFF Research Database (Denmark)

    Schjøth, Lars; Fogh Olsen, Ole; Sporring, Jon

    2007-01-01

    . To address this problem we introduce a novel photon mapping algorithm based on nonlinear anisotropic diffusion. Our algorithm adapts according to the structure of the photon map such that smoothing occurs along edges and structures and not across. In this way we preserve the important illumination features...

  4. Graphene-based spaser

    Science.gov (United States)

    Berman, Oleg; Kezerashvili, Roman; Lozovik, Yurii

    2013-03-01

    We propose graphene-based surface plasmon amplification by stimulated emission of radiation (spaser) formed in the graphene nanoribbon located near a semiconductor quantum dot (QD). The population inversion of the two electron levels of the QD can be achieved by applying external electric current or laser pumping. If the frequency of the dipole plasmon resonance in a graphene nanoribbon comes in the resonance with the transition frequency for the QD, it is possible to excite plasmons and generate the coherent surface plasmon states in the graphene nanoribbon. Therefore, the oscillating dipole in the QD excites coherent surface plasmons in the graphene nanoribbon. By solving the system of equations for the number of coherent localized plasmons in a graphene-based spaser the optimal design, optimal width of graphene nanoribbon and optimal regime for the graphene-based spaser are found. The minimal size and minimal threshold pumping intensity for the graphene-based spaser are obtained. The advantage of using graphene for the spaser is discussed.

  5. Molecule-based magnets

    Indian Academy of Sciences (India)

    Administrator

    Being weakly coloured, unlike their opaque classical magnet 'cousins' listed above, possibilities of ..... which confers a memory effect on it. Stronger coercive fields are expected for Co. 2+. -based molecular ... of them a colour change, too, occurs reversibly and simultaneously with the change in magnetic properties at.

  6. Fundamental research data base

    Science.gov (United States)

    1983-01-01

    A fundamental research data base containing ground truth, image, and Badhwar profile feature data for 17 North Dakota, South Dakota, and Minnesota agricultural sites is described. Image data was provided for a minimum of four acquisition dates for each site and all four images were registered to one another.

  7. Base tree property

    Czech Academy of Sciences Publication Activity Database

    Balcar, B.; Doucha, Michal; Hrušák, M.

    2015-01-01

    Roč. 32, č. 1 (2015), s. 69-81 ISSN 0167-8094 R&D Projects: GA AV ČR IAA100190902 Institutional support: RVO:67985840 Keywords : forcing * Boolean algebras * base tree Subject RIV: BA - General Mathematics Impact factor: 0.614, year: 2015 http://link.springer.com/article/10.1007/s11083-013-9316-2

  8. Steel column base classification

    OpenAIRE

    Jaspart, J.P.; Wald, F.; Weynand, K.; Gresnigt, A.M.

    2008-01-01

    The influence of the rotational characteristics of the column bases on the structural frame response is discussed and specific design criteria for stiffness classification into semi-rigid and rigid joints are derived. The particular case of an industrial portal frame is then considered. Peer reviewed

  9. Web Based VRML Modelling

    NARCIS (Netherlands)

    Kiss, S.; Sarfraz, M.

    2004-01-01

    Presents a method to connect VRML (Virtual Reality Modeling Language) and Java components in a Web page using EAI (External Authoring Interface), which makes it possible to interactively generate and edit VRML meshes. The meshes used are based on regular grids, to provide an interaction and modeling

  10. Web Based VRML Modelling

    NARCIS (Netherlands)

    Kiss, S.; Banissi, E.; Khosrowshahi, F.; Sarfraz, M.; Ursyn, A.

    2001-01-01

    Presents a method to connect VRML (Virtual Reality Modeling Language) and Java components in a Web page using EAI (External Authoring Interface), which makes it possible to interactively generate and edit VRML meshes. The meshes used are based on regular grids, to provide an interaction and modeling

  11. based gel polymer electrolytes

    Indian Academy of Sciences (India)

    operating systems. With this situation, attempts have been made in poly (ethylene oxide) (PEO) based polymer electrolytes to reach an appreciable electrical conducti- vity at ambient temperature (Wright 1975; Martuscelli et al 1984). Generally solid polymer electrolytes have many advantages, viz. high ionic conductivity, ...

  12. Dictionary Based Image Segmentation

    DEFF Research Database (Denmark)

    Dahl, Anders Bjorholm; Dahl, Vedrana Andersen

    2015-01-01

    We propose a method for weakly supervised segmentation of natural images, which may contain both textured or non-textured regions. Our texture representation is based on a dictionary of image patches. To divide an image into separated regions with similar texture we use an implicit level sets...

  13. Molecule-based magnets

    Indian Academy of Sciences (India)

    Administrator

    SmCo5, Nd2Fe14B etc are all atom-based, and their preparation/processing require high temperature routes. Employing ... synthesis of molecular magnets in 1986, a large variety of them have been synthesized, which can be catego- rized on the basis of the ..... magnetic behaviour of Fe[Fe(CN)6⋅xH2O nanoparticles.

  14. REST based service composition

    DEFF Research Database (Denmark)

    Grönvall, Erik; Ingstrup, Mads; Pløger, Morten

    2011-01-01

    This paper presents an ongoing work developing and testing a Service Composition framework based upon the REST architecture named SECREST. A minimalistic approach have been favored instead of a creating a complete infrastructure. One focus has been on the system's interaction model. Indeed, an ai...

  15. Zero-Base Budgeting.

    Science.gov (United States)

    Harvey, L. James

    The concept of Zero-Base Budgeting (ZBB) is discussed in terms of its application, advantages, disadvantages, and implementation in an effective planning, management, and evaluation (PME) system. A ZBB system requires administrators to: review all programs and expenditures annually, set clear cut goals, and analyze all possible alternatives for…

  16. Zero-Base Budgeting.

    Science.gov (United States)

    Yagielski, John

    In outline form, this document presents basic information on the school district, the reasons the district considered zero-base budgeting (ZBB), the formation and membership of the advisory School Cost Analysis Team, the district's investigation of the ZBB concept, an overview of the ways the district used the ZBB process, the identification of…

  17. Internet Based Benchmarking

    OpenAIRE

    Bogetoft, Peter; Nielsen, Kurt

    2002-01-01

    We discuss the design of interactive, internet based benchmarking using parametric (statistical) as well as non-parametric (DEA) models. The user receives benchmarks and improvement potentials. The user is also given the possibility to search different efficiency frontiers and hereby to explore alternative improvement strategies. An implementation of both a parametric and a non parametric model are presented.

  18. Mutually unbiased bases

    Indian Academy of Sciences (India)

    ... we show how, by exploiting certain freedom in the Wootters–Fields construction, the task of explicitly writing down such bases can be simplified for the case when is an odd prime. In particular, we express the results entirely in terms of the character vectors of the cyclic group of order . We also analyse the connection ...

  19. Surfel Based Geometry Resonstruction

    DEFF Research Database (Denmark)

    Andersen, Vedrana; Aanæs, Henrik; Bærentzen, Jakob Andreas

    2010-01-01

    We propose a method for retrieving a piecewise smooth surface from noisy data. In data acquired by a scanning process sampled points are almost never on the discontinuities making reconstruction of surfaces with sharp features difficult. Our method is based on a Markov Random Field (MRF) formulat...

  20. Performance based fault diagnosis

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik

    2002-01-01

    Different aspects of fault detection and fault isolation in closed-loop systems are considered. It is shown that using the standard setup known from feedback control, it is possible to formulate fault diagnosis problems based on a performance index in this general standard setup. It is also shown...

  1. Cotton-based nonwovens

    Science.gov (United States)

    This article is an abbreviated description of a new cotton-based nonwovens research program at the Southern Regional Research Center, which is one of the four regional research centers of the Agricultural Research Service, U.S. Department of Agriculture. Since cotton is a significant cash crop inte...

  2. Diffusion Based Photon Mapping

    DEFF Research Database (Denmark)

    Schjøth, Lars; Sporring, Jon; Fogh Olsen, Ole

    2008-01-01

    . To address this problem, we introduce a photon mapping algorithm based on nonlinear anisotropic diffusion. Our algorithm adapts according to the structure of the photon map such that smoothing occurs along edges and structures and not across. In this way, we preserve important illumination features, while...

  3. Spiritual-based Leadership

    DEFF Research Database (Denmark)

    Pruzan, Peter

    2015-01-01

    Although far from mainstream, the concept of spiritual-based leadership is emerging as an inclusive and yet highly personal approach to leadership that integrates a leader’s inner perspectives on identity, purpose, responsibility and success with her or his decisions and actions in the outer worl...

  4. Convolution based profile fitting

    International Nuclear Information System (INIS)

    Kern, A.; Coelho, A.A.; Cheary, R.W.

    2002-01-01

    Full text: In convolution based profile fitting, profiles are generated by convoluting functions together to form the observed profile shape. For a convolution of 'n' functions this process can be written as, Y(2θ)=F 1 (2θ)x F 2 (2θ)x... x F i (2θ)x....xF n (2θ). In powder diffractometry the functions F i (2θ) can be interpreted as the aberration functions of the diffractometer, but in general any combination of appropriate functions for F i (2θ) may be used in this context. Most direct convolution fitting methods are restricted to combinations of F i (2θ) that can be convoluted analytically (e.g. GSAS) such as Lorentzians, Gaussians, the hat (impulse) function and the exponential function. However, software such as TOPAS is now available that can accurately convolute and refine a wide variety of profile shapes numerically, including user defined profiles, without the need to convolute analytically. Some of the most important advantages of modern convolution based profile fitting are: 1) virtually any peak shape and angle dependence can normally be described using minimal profile parameters in laboratory and synchrotron X-ray data as well as in CW and TOF neutron data. This is possible because numerical convolution and numerical differentiation is used within the refinement procedure so that a wide range of functions can easily be incorporated into the convolution equation; 2) it can use physically based diffractometer models by convoluting the instrument aberration functions. This can be done for most laboratory based X-ray powder diffractometer configurations including conventional divergent beam instruments, parallel beam instruments, and diffractometers used for asymmetric diffraction. It can also accommodate various optical elements (e.g. multilayers and monochromators) and detector systems (e.g. point and position sensitive detectors) and has already been applied to neutron powder diffraction systems (e.g. ANSTO) as well as synchrotron based

  5. Spintronics-based computing

    CERN Document Server

    Prenat, Guillaume

    2015-01-01

    This book provides a comprehensive introduction to spintronics-based computing for the next generation of ultra-low power/highly reliable logic, which is widely considered a promising candidate to replace conventional, pure CMOS-based logic. It will cover aspects from device to system-level, including magnetic memory cells, device modeling, hybrid circuit structure, design methodology, CAD tools, and technological integration methods. This book is accessible to a variety of readers and little or no background in magnetism and spin electronics are required to understand its content.  The multidisciplinary team of expert authors from circuits, devices, computer architecture, CAD and system design reveal to readers the potential of spintronics nanodevices to reduce power consumption, improve reliability and enable new functionality.  .

  6. PACS Data Base Design

    Science.gov (United States)

    Zeleznik, Michael P.; Maguire, G. Q.; Baxter, B.

    1983-05-01

    A PACS database must manage three different types of data; structured data in the form of patient/exam identification information, and unstructured data in the form of text and images. Queries based on the content of text documents as well as the content of images must be suported, in addition to those based on standard, well structured keys such as name, age and sex. We model the PACS database as three logically distinct databases, each supporting one of these data types, with mapping structures relating all three. Several design issues which have a bearing, both on these models and on physical implemtations, are discussed. Because image database systems are the least understood at this time, most of the paper focusses on the them. We briefly discuss current trends in structured and text databases, without discussing commercial systems, and then present some current methods of implementing image database systems.

  7. Concrete lunar base investigation

    Science.gov (United States)

    Lin, T. D.; Senseny, Jonathan A.; Arp, Larry D.; Lindbergh, Charles

    1992-01-01

    This paper presents results of structural analyses and a preliminary design of a precast, prestressed concrete lunar base subjected to 1-atm internal pressure. The proposed infrastructure measures 120 ft in diameter and 72 ft in height, providing 33,000 sq ft of work area for scientific and industrial operations. Three loading conditions were considered in the design (1) during construction, (2) under pressurization, and (3) during an air-leak scenario. A floating foundation, capable of rigid body rotation and translation as the lunar soil beneath it yields, was developed to support the infrastructure and to ensure the airtightness of the system. Results reveal that it is feasible to use precast, prestressed concrete for construction of large lunar bases on the Moon.

  8. Technology based Education System

    DEFF Research Database (Denmark)

    Kant Hiran, Kamal; Doshi, Ruchi; Henten, Anders

    2016-01-01

    Abstract - Education plays a very important role for the development of the country. Education has multiple dimensions from schooling to higher education and research. In all these domains, there is invariably a need for technology based teaching and learning tools are highly demanded in the acad......Abstract - Education plays a very important role for the development of the country. Education has multiple dimensions from schooling to higher education and research. In all these domains, there is invariably a need for technology based teaching and learning tools are highly demanded...... and operational data that is used within a university for daily routine work. This paper presents a hybrid cloud computing model for higher education institutions to share intellectual data. Moreover, it proposes, the strategies for the implementation of the cloud computing in the academic institutions. Keywords...

  9. Animation-based Sketching

    DEFF Research Database (Denmark)

    Vistisen, Peter

    of contributions. In the produced work, I expand upon animation as a sketching approach to communicate, and explore interaction and user experience design concepts that are hard to grasp via traditional means of sketching. I propose that the sequential, temporal, material and narrative qualities of animation may...... experiments has been carried out, applying animation-based sketching in various contexts and at varying points in the design process. In the studies, I evaluate the viability of the approach, the practical integration into the design process, and map how consensus between stakeholders in design can...... be established through animation -based sketches. Thus, the scope of this project is practice-inclined, towards qualifying animation as an approach for design sketching in practice....

  10. Sparse approximation with bases

    CERN Document Server

    2015-01-01

    This book systematically presents recent fundamental results on greedy approximation with respect to bases. Motivated by numerous applications, the last decade has seen great successes in studying nonlinear sparse approximation. Recent findings have established that greedy-type algorithms are suitable methods of nonlinear approximation in both sparse approximation with respect to bases and sparse approximation with respect to redundant systems. These insights, combined with some previous fundamental results, form the basis for constructing the theory of greedy approximation. Taking into account the theoretical and practical demand for this kind of theory, the book systematically elaborates a theoretical framework for greedy approximation and its applications.  The book addresses the needs of researchers working in numerical mathematics, harmonic analysis, and functional analysis. It quickly takes the reader from classical results to the latest frontier, but is written at the level of a graduate course and do...

  11. Maintaining Relationship Based Procurement

    Directory of Open Access Journals (Sweden)

    Peter Davis

    2012-11-01

    Full Text Available Alliance and relationship projects are increasingin number and represent a large pool of work. Tobe successful relationship style contracts dependon soft-dollar factors, particularly the participants'ability to work together within an agreedframework, generally they are not based on lowbid tendering. Participants should be prepared todo business in an open environment based ontrust and mutually agreed governance. Theresearch evaluates relationship maintenance inthe implementation phase of constructionalliances - a particular derivative of relationshipstyle contracts. To determine the factors thatcontribute to relationship maintenance forty-nineexperienced Australian alliance projectmanagers were interviewed. The main findingswere; the development of relationships early inthe project form building blocks of success fromwhich relationships are maintained and projectvalue added; quality facilitation plays animportant part in relationship maintenance and ahybrid organisation created as a result of alliancedevelopment overcomes destructiveorganisational boundaries. Relationshipmaintenance is integral to alliance project controland failure to formalise it and pay attention toprocess and past outcomes will undermine analliance project's potential for success.

  12. Fusion safety data base

    International Nuclear Information System (INIS)

    Laats, E.T.; Hardy, H.A.

    1983-01-01

    The purpose of this Fusion Safety Data Base Program is to provide a repository of data for the design and development of safe commercial fusion reactors. The program is sponsored by the United States Department of Energy (DOE), Office of Fusion Energy. The function of the program is to collect, examine, permanently store, and make available the safety data to the entire US magnetic-fusion energy community. The sources of data will include domestic and foreign fusion reactor safety-related research programs. Any participant in the DOE Program may use the Data Base Program from his terminal through user friendly dialog and can view the contents in the form of text, tables, graphs, or system diagrams

  13. Conducting Polymer Based Nanobiosensors

    Directory of Open Access Journals (Sweden)

    Chul Soon Park

    2016-06-01

    Full Text Available In recent years, conducting polymer (CP nanomaterials have been used in a variety of fields, such as in energy, environmental, and biomedical applications, owing to their outstanding chemical and physical properties compared to conventional metal materials. In particular, nanobiosensors based on CP nanomaterials exhibit excellent performance sensing target molecules. The performance of CP nanobiosensors varies based on their size, shape, conductivity, and morphology, among other characteristics. Therefore, in this review, we provide an overview of the techniques commonly used to fabricate novel CP nanomaterials and their biosensor applications, including aptasensors, field-effect transistor (FET biosensors, human sense mimicking biosensors, and immunoassays. We also discuss prospects for state-of-the-art nanobiosensors using CP nanomaterials by focusing on strategies to overcome the current limitations.

  14. Knowledge based maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Sturm, A. [Hamburgische Electacitaets-Werke AG Hamburg (Germany)

    1997-12-31

    The establishment of maintenance strategies is of crucial significance for the reliability of a plant and the economic efficiency of maintenance measures. Knowledge about the condition of components and plants from the technical and business management point of view therefore becomes one of the fundamental questions and the key to efficient management and maintenance. A new way to determine the maintenance strategy can be called: Knowledge Based Maintenance. A simple method for determining strategies while taking the technical condition of the components of the production process into account to the greatest possible degree which can be shown. A software with an algorithm for Knowledge Based Maintenance leads the user during complex work to the determination of maintenance strategies for this complex plant components. (orig.)

  15. Arduino based laser control

    OpenAIRE

    Bernal Muñoz, Ferran

    2015-01-01

    ARDUINO is a vey usefull platform for prototypes. In this project ARDUINO will be used for controling a Semiconductor Tuneable Laser. [ANGLÈS] Diode laser for communications control based on an Arduino board. Temperature control implementation. Software and hardware protection for the laser implementation. [CASTELLÀ] Control de un láser de comunicaciones ópticas desde el ordenador utilizando una placa Arduino. Implementación de un control de temperatura y protección software y hardware ...

  16. Design bases - Concrete structures

    International Nuclear Information System (INIS)

    Diaz-Llanos Ros, M.

    1993-01-01

    The most suitable title for Section 2 is 'Design Bases', which covers not only calculation but also the following areas: - Structural design concepts. - Project criteria. - Material specifications. These concepts are developed in more detail in the following sections. The numbering in this document is neither complete nor hierarchical since, for easier cross referencing, it corresponds to the paragraphs of Eurocode 2 Part 1 (hereinafter 'EUR-2') which are commented on. (author)

  17. Boid Based Timetable Generation

    Science.gov (United States)

    Fulmański, Piotr

    2008-09-01

    The general timetabling problem consists of scheduling a number of events into a finite number of periods so that no individual entity is required to attend two or more events simultaneously. In most cases there will also be restrictions on the amount of resources, time etc. In this document we try to investigate a new method of timetable generation based not on popular evolutionary approach but on boids concept.

  18. Copper Pyrimidine based MOFs

    Indian Academy of Sciences (India)

    Cl..Cu.. interactions but restricted ..Cu..N N..Cu interacations. Supramolecular isomers of Br and I are reported for the first time in this paper. [Cu2I(pdz)X2]. Figure S18. Self assembly of the simultaneous presence of tecton {Cu(sol)3X} and {Cu(pdz)(sol)2X} result in [Cu2I(pdz)X2]. 1. Table S3. Copper Pyrimidine based MOFs ...

  19. Air Force Smart Bases

    Science.gov (United States)

    2017-10-19

    and mobility for generating combat power while maintaining cybersecurity and accruing the benefits of technology in their lives . Figure 2...Designers ideate 100’s if not 1000’s of ways IoT and smart base technologies may improve the lives of Airmen. Figure 3: A conceptual AF mobile...innovation that unlock mission capabilities for Airmen. Both use cases are important (and can be integrated), but the functionals must continue to remind

  20. Microbead agglutination based assays

    KAUST Repository

    Kodzius, Rimantas

    2013-01-21

    We report a simple and rapid room temperature assay for point-of-care (POC) testing that is based on specific agglutination. Agglutination tests are based on aggregation of microbeads in the presence of a specific analyte thus enabling the macroscopic observation. Such tests are most often used to explore antibody-antigen reactions. Agglutination has been used for protein assays using a biotin/streptavidin system as well as a hybridization based assay. The agglutination systems are prone to selftermination of the linking analyte, prone to active site saturation and loss of agglomeration at high analyte concentrations. We investigated the molecular target/ligand interaction, explaining the common agglutination problems related to analyte self-termination, linkage of the analyte to the same bead instead of different microbeads. We classified the agglutination process into three kinds of assays: a two- component assay, a three-component assay and a stepped three- component assay. Although we compared these three kinds of assays for recognizing DNA and protein molecules, the assay can be used for virtually any molecule, including ions and metabolites. In total, the optimized assay permits detecting analytes with high sensitivity in a short time, 5 min, at room temperature. Such a system is appropriate for POC testing.

  1. As bases do petismo

    Directory of Open Access Journals (Sweden)

    David Samuels

    2004-10-01

    Full Text Available A partir dos dados do ESEB de 2002 o autor realiza um estudo das bases eleitorais do PT e de hipóteses sobre a natureza do petismo. Através de técnicas estatísticas multivariadas, são testadas relações do petismo com variáveis demográficas, socioeconômicas e variáveis relativas a questões políticas específicas. Os resultados apontam que apenas a escolaridade tem uma associação específica com o petismo, com implicações para o seu comportamento sócio-político.Based on the results of the 2002 Brazilian Electoral Study, the author analyses the electoral bases of the Worker´s Party and the factors associated with the "petismo". The relationships between the "petismo"and the socioeconomic, demographic and political variables are tested using multivariate analysis. The results indicate that the only "social category"associated with "petismo"is level of education, and it has clear implications to their social and political behavior.

  2. Knowledge-based utility

    International Nuclear Information System (INIS)

    Chwalowski, M.

    1997-01-01

    This presentation provides industry examples of successful marketing practices by companies facing deregulation and competition. The common thread through the examples is that long term survival of today's utility structure is dependent on the strategic role of knowledge. As opposed to regulated monopolies which usually own huge physical assets and have very little intelligence about their customers, unregulated enterprises tend to be knowledge-based, characterized by higher market value than book value. A knowledge-based enterprise gathers data, creates information and develops knowledge by leveraging it as a competitive weapon. It institutionalizes human knowledge as a corporate asset for use over and over again by the use of databases, computer networks, patents, billing, collection and customer services (BCCS), branded interfaces and management capabilities. Activities to become knowledge-based such as replacing inventory/fixed assets with information about material usage to reduce expenditure and achieve more efficient operations, and by focusing on integration and value-adding delivery capabilities, were reviewed

  3. Evidence-based policy

    DEFF Research Database (Denmark)

    Vohnsen, Nina Holm

    2013-01-01

    A current ambition in welfare states as diverse as Denmark, the UK, and in the USA is to base political decision making on rigorous research (Cartwright et al 2009; Mulgan 2009; Bason 2010). Sound as this might seem the ambition has nevertheless been problematized by both policy-makers and the re......A current ambition in welfare states as diverse as Denmark, the UK, and in the USA is to base political decision making on rigorous research (Cartwright et al 2009; Mulgan 2009; Bason 2010). Sound as this might seem the ambition has nevertheless been problematized by both policy......-makers and the research community (e.g. Boden & Epstein 2006; House of Commons 2006; Cartwright et al 2009; Rod 2010; Vohnsen 2011). This article intends to draw out some general pitfalls in the curious meeting of science and politics by focusing on a particular attempt to make evidence-based legislation in Denmark (for...... a full account, see Vohnsen 2011). These insights will be relevant for the anthropological researcher of legislative processes who wishes to move beyond a merely discursive approach to the study of policy and politics....

  4. Effect of the kinetics of ammonium and nitrite oxidation on nitritation success or failure for different biofilm reactor geometries

    DEFF Research Database (Denmark)

    Lackner, Susanne; Smets, Barth F.

    2012-01-01

    The effect of biokinetics on nitritation was investigated in two biofilm geometries, the Membrane Aerated Biofilm Reactor (MABR) and a conventional biofilm system. A 1D biofilm model was used and evaluated by global sensitivity analysis using the variance based Sobol method. The main focus...... strongly depends on the chosen kinetic parameters of AOB and NOB. The maximum specific growth rates (μmax,AOB and μmax,NOB) had the strongest impact on nitritation efficiency (NE). In comparison, the counter-diffusion geometry yielded more parameter combinations (27.5%) that resulted in high NE than the co...

  5. Conjugate whole-body scanning system for quantitative measurement of organ distribution in vivo

    International Nuclear Information System (INIS)

    Tsui, B.M.W.; Chen, C.T.; Yasillo, N.J.; Ortega, C.J.; Charleston, D.B.; Lathrop, K.A.

    1979-01-01

    The determination of accurate, quantitative, biokinetic distribution of an internally dispersed radionuclide in humans is important in making realistic radiation absorbed dose estimates, studying biochemical transformations in health and disease, and developing clinical procedures indicative of abnormal functions. In order to collect these data, a whole-body imaging system is required which provides both adequate spatial resolution and some means of absolute quantitation. Based on these considerations, a new whole-body scanning system has been designed and constructed that employs the conjugate counting technique. The conjugate whole-body scanning system provides an efficient and accurate means of collecting absolute quantitative organ distribution data of radioactivity in vivo

  6. Shall we upgrade one-dimensional secondary settler models used in WWTP simulators? – An assessment of model structure uncertainty and its propagation

    DEFF Research Database (Denmark)

    Plósz, Benedek; De Clercq, Jeriffa; Nopens, Ingmar

    2011-01-01

    on characterising particulate organics in wastewater and on bacteria growth is well-established, whereas 1-D SST models and their impact on biomass concentration predictions are still poorly understood. A rigorous assessment of two 1-DSST models is thus presented: one based on hyperbolic (the widely used Taka´ cs...... results demonstrates a considerably improved 1-D model realism using the convection-dispersion model in terms of SBH, XTSS,RAS and XTSS,Eff. Third, to assess the propagation of uncertainty derived from settler model structure to the biokinetic model, the impact of the SST model as sub-model in a plant...

  7. Development and evaluation of a technique for in vivo monitoring of 60Co in the lungs

    International Nuclear Information System (INIS)

    Mello, J.Q. de; Lucena, E.A.; Dantas, A.L.A.; Dantas, B.M.

    2015-01-01

    60 Co is a fission product of 235 U and represents a risk of internal exposure of workers in nuclear power plants, especially those involved in the maintenance of potentially contaminated parts and equipment. The control of 60 Co intake by inhalation can be performed through in vivo monitoring. This work describes the evaluation of a technique through the minimum detectable activity and the corresponding minimum detectable effective doses, based on biokinetic and dosimetric models of 60 Co in the human body. The results allow to state that the technique is suitable either for monitoring of occupational exposures or evaluation of accidental intakes. (author)

  8. Nanoplatform-based molecular imaging

    National Research Council Canada - National Science Library

    Chen, Xiaoyuan

    2011-01-01

    "Nanoplathform-Based Molecular Imaging provides rationale for using nanoparticle-based probes for molecular imaging, then discusses general strategies for this underutilized, yet promising, technology...

  9. Comparison of sequence-based and structure-based phylogenetic ...

    Indian Academy of Sciences (India)

    Prakash

    Sequence-based and structure-based phylogeny. 85. J. Biosci. 32(1), January 2007 dispersion is independent of phylogenetic tree construction algorithms. 3. ... two groups only. 3.1 Families with high correlation between sequence- based and structure-based phylogenetic trees. There are 27 families with considerably high ...

  10. DOM Based XSS Detecting Method Based on Phantomjs

    Science.gov (United States)

    Dong, Ri-Zhan; Ling, Jie; Liu, Yi

    Because malicious code does not appear in html source code, DOM based XSS cannot be detected by traditional methods. By analyzing the causes of DOM based XSS, this paper proposes a detection method of DOM based XSS based on phantomjs. This paper uses function hijacking to detect dangerous operation and achieves a prototype system. Comparing with existing tools shows that the system improves the detection rate and the method is effective to detect DOM based XSS.

  11. Evidence-based guidelines

    DEFF Research Database (Denmark)

    Rovira, Àlex; Wattjes, Mike P; Tintoré, Mar

    2015-01-01

    The clinical use of MRI in patients with multiple sclerosis (MS) has advanced markedly over the past few years. Technical improvements and continuously emerging data from clinical trials and observational studies have contributed to the enhanced performance of this tool for achieving a prompt...... diagnosis in patients with MS. The aim of this article is to provide guidelines for the implementation of MRI of the brain and spinal cord in the diagnosis of patients who are suspected of having MS. These guidelines are based on an extensive review of the recent literature, as well as on the personal...... of MRI in clinical practice for the diagnosis of MS....

  12. Vision-based interaction

    CERN Document Server

    Turk, Matthew

    2013-01-01

    In its early years, the field of computer vision was largely motivated by researchers seeking computational models of biological vision and solutions to practical problems in manufacturing, defense, and medicine. For the past two decades or so, there has been an increasing interest in computer vision as an input modality in the context of human-computer interaction. Such vision-based interaction can endow interactive systems with visual capabilities similar to those important to human-human interaction, in order to perceive non-verbal cues and incorporate this information in applications such

  13. Polymerization Using Phosphazene Bases

    KAUST Repository

    Zhao, Junpeng

    2015-09-01

    In the recent rise of metal-free polymerization techniques, organic phosphazene superbases have shown their remarkable strength as promoter/catalyst for the anionic polymerization of various types of monomers. Generally, the complexation of phosphazene base with the counterion (proton or lithium cation) significantly improves the nucleophilicity of the initiator/chain end resulting in highly enhanced polymerization rates, as compared with conventional metalbased initiating systems. In this chapter, the general features of phosphazenepromoted/catalyzed polymerizations and the applications in macromolecular engineering (synthesis of functionalized polymers, block copolymers, and macromolecular architectures) are discussed with challenges and perspectives being pointed out.

  14. Oil based mud discharges

    International Nuclear Information System (INIS)

    Tiesma, R.

    1996-01-01

    The intensive use of oil based muds by the offshore oil and gas industry during the 1980s has caused considerable contamination around drilling sites. A recent investigation on the Norwegian continental shelf indicates that the situation is much worse than previously thought. This material suggests that oil pollution of this kind could be damaging the North Sea's endangered fish stocks, including cod, haddock and plaice. The amount of oil discharged in the UK sector is many times higher than in the other sectors, suggesting that the problem there may be even more serious. The amount discharged in the Dutch and Norwegian sectors are comparable. (author)

  15. Agent-Based Optimization

    CERN Document Server

    Jędrzejowicz, Piotr; Kacprzyk, Janusz

    2013-01-01

    This volume presents a collection of original research works by leading specialists focusing on novel and promising approaches in which the multi-agent system paradigm is used to support, enhance or replace traditional approaches to solving difficult optimization problems. The editors have invited several well-known specialists to present their solutions, tools, and models falling under the common denominator of the agent-based optimization. The book consists of eight chapters covering examples of application of the multi-agent paradigm and respective customized tools to solve  difficult optimization problems arising in different areas such as machine learning, scheduling, transportation and, more generally, distributed and cooperative problem solving.

  16. Teradata data base computer

    Energy Technology Data Exchange (ETDEWEB)

    1984-04-01

    To meet the growing demand for information management of large databases, Teradata Corporation has introduced the DBC/1012 data base computer, an IBM plug-compatible system that can handle data volumes up to a trillion bytes. Teradata estimates the DBC/1012 to be one-third the cost of an all-software relational system on a general purpose mainframe. Cost effectiveness, as well as fault tolerance, is achieved by a parallel architecture which processes data asynchronously using multiple independent microprocessors. Another cost saving results from the resources on the host mainframe that become available once the mainframe is relieved of the burden of maintaining the database.

  17. Problem Based Game Design

    DEFF Research Database (Denmark)

    Reng, Lars; Schoenau-Fog, Henrik

    2011-01-01

    At Aalborg University’s department of Medialogy, we are utilizing the Problem Based Learning method to encourage students to solve game design problems by pushing the boundaries and designing innovative games. This paper is concerned with describing this method, how students employ it in various...... projects and how they learn to analyse, design, and develop for innovation by using it. We will present various cases to exemplify the approach and focus on how the method engages students and aspires for innovation in digital entertainment and games....

  18. LIGHTWEIGHT CONCRETE BASED GRANSHLAK

    Directory of Open Access Journals (Sweden)

    NETESA M. I.

    2016-02-01

    Full Text Available Raising of problem. Concrete advisable to obtain a low strength with local secondary resources for recycling and reduce the environmental burden on the environment. But it is important to design such concrete compositions with a reduced flow of cement. It is known that the coefficient of efficiency of use of cement in the concrete of the heavy and B10 is less than about 0.5, which is almost two times smaller than in class B15 concrete and above. Even lower coefficient of efficiency in light concrete cement low strength. Therefore, it is important to find patterns determining the composition of lightweight concrete based on local-products industry with more efficient use of cement in them. Purpose.. Based on the analysis of earlier research results, including with the use of methods of mathematical planning of experiments to determine the concrete contents, which can provide the requirements for the underlying layers of the floor, the compressive strength of which should correspond to the class B5. It is important to provide the required strength at minimum flow of the cement, which is the most expensive and energy-intensive part of concrete. Conclusion. Analysis of the test results of control samples of concrete in 28-day-old, the following laws. The required tensile strength of concrete compressive strength of 7.0 MPa can be obtained in the test range when used in formulations as a filler as the Dnieper hydroelectric power station fly ash and tailings Krivoy Rog iron ore YuGOK. To ensure providing the required characteristic strength of the concrete in the underlying layers of the floor is advisable to use a nominal composition per cubic meter of concrete: cement 160 kg granshlaka Plant named after Petrovsky, 675 kg of fly ash Dnieper HPP 390 kg, 400 kg of sand, 230 liters of water. Thus, while ensuring rational grain composition components can obtain the desired strength lightweight concrete based granshlaka plant Petrovsky, using as fillers

  19. Web Based Customized Design

    OpenAIRE

    Moi, Morten Benestad

    2013-01-01

    This thesis studies the methods needed to create a web based application to remotely customize a CAD model. This includes customizing a CAD model by using a graphical user interface to be able to remotely control the inputs to- and outputs from the model in NX, and to get the result sent back to the user. Using CAD systems such as NX requires intensive training, is often a slow process and gives a lot of room for errors. An intuitive, simple user interface will eliminate the need for CAD trai...

  20. Sustainability Base Construction Update

    Science.gov (United States)

    Mewhinney, Michael

    2012-01-01

    Construction of the new Sustainability Base Collaborative support facility, expected to become the highest performing building in the federal government continues at NASA's Ames Research Center, Moffet Field, Calif. The new building is designed to achieve a platinum rating under the leadership in Energy and Environment Design (LEED) new construction standards for environmentally sustainable construction developed by the U. S. Green Building Council, Washington, D. C. When completed by the end of 2011, the $20.6 million building will feature near zero net energy consumption, use 90 percent less potable water than conventionally build buildings of equivalent size, and will result in reduced building maintenance costs.

  1. Cellular based cancer vaccines

    DEFF Research Database (Denmark)

    Hansen, M; Met, Ö; Svane, I M

    2012-01-01

    Cancer vaccines designed to re-calibrate the existing host-tumour interaction, tipping the balance from tumor acceptance towards tumor control holds huge potential to complement traditional cancer therapies. In general, limited success has been achieved with vaccines composed of tumor...... to transiently affect in vitro migration via autocrine receptor-mediated endocytosis of CCR7. In the current review, we discuss optimal design of DC maturation focused on pre-clinical as well as clinical results from standard and polarized dendritic cell based cancer vaccines....

  2. Pitch Based Sound Classification

    DEFF Research Database (Denmark)

    Nielsen, Andreas Brinch; Hansen, Lars Kai; Kjems, U

    2006-01-01

    A sound classification model is presented that can classify signals into music, noise and speech. The model extracts the pitch of the signal using the harmonic product spectrum. Based on the pitch estimate and a pitch error measure, features are created and used in a probabilistic model with soft......-max output function. Both linear and quadratic inputs are used. The model is trained on 2 hours of sound and tested on publicly available data. A test classification error below 0.05 with 1 s classification windows is achieved. Further more it is shown that linear input performs as well as a quadratic...

  3. Accelerator-based BNCT.

    Science.gov (United States)

    Kreiner, A J; Baldo, M; Bergueiro, J R; Cartelli, D; Castell, W; Thatar Vento, V; Gomez Asoia, J; Mercuri, D; Padulo, J; Suarez Sandin, J C; Erhardt, J; Kesque, J M; Valda, A A; Debray, M E; Somacal, H R; Igarzabal, M; Minsky, D M; Herrera, M S; Capoulat, M E; Gonzalez, S J; del Grosso, M F; Gagetti, L; Suarez Anzorena, M; Gun, M; Carranza, O

    2014-06-01

    The activity in accelerator development for accelerator-based BNCT (AB-BNCT) both worldwide and in Argentina is described. Projects in Russia, UK, Italy, Japan, Israel, and Argentina to develop AB-BNCT around different types of accelerators are briefly presented. In particular, the present status and recent progress of the Argentine project will be reviewed. The topics will cover: intense ion sources, accelerator tubes, transport of intense beams, beam diagnostics, the (9)Be(d,n) reaction as a possible neutron source, Beam Shaping Assemblies (BSA), a treatment room, and treatment planning in realistic cases. © 2013 Elsevier Ltd. All rights reserved.

  4. Situation based housing

    DEFF Research Database (Denmark)

    Duelund Mortensen, Peder; Welling, Helen; Wiell Nordberg, Lene

    2007-01-01

    of approaches to these goals. This working paper reviews not only a selection of new housing types, but also dwellings from the past, which each contain an aspect of changeability. Our study is based on information from users in the selected housing schemes, gathered from questionnaires, information about...... for living. The suitable condition consists of the dwelling's ability for physical displacement, spatial changes that can suit changing life styles. The situational condition is the not defined, the unfinished and the transitory, which continuously challenges the imagination and calls for the experiment. Our...

  5. Knowledge based Entrepreneurship

    DEFF Research Database (Denmark)

    Heebøll, John

    This book is dedicated enterprising people with a technical or a scientific background who consider commercializing ideas and inventions within their field of expertise via a new business activity or a new company. It aims at distilling experiences from many successful and not so successful start......-up ventures from the Technical University of Denmark, 1988 – 2008 into practical, portable knowledge that can be used by future knowledge-based entrepreneurs to set up new companies efficiently or to stay away from it; to do what’s needed and avoid the pitfalls....

  6. Problem Based Learning Online

    DEFF Research Database (Denmark)

    Kolbæk, Ditte

    2018-01-01

    “How do two online learning designs affect student engagement in the PBL online modules?” The empirical data were collected and analyzed using a netnographic approach. The study finds that concepts such as self-directed learning and active involvement may be perceived very differently from the students......Problem- and project- based learning (PBL) was originally developed for collaboration between physically present students and teachers, but political decisions at many universities also require that collaboration, dialogues, and other PBL activities take place online. Teachers design learning...

  7. Study of the biokinetic behavior of {sup 99m}Tc-DMSA in renal scintigraphy of pediatric patients; Estudo de comportamento biocinetico do {sup 99m}Tc-DMSA em cintilografia renal de pacientes pediatricos

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Felipe Simas dos

    2013-07-01

    In Brazil, renal studies with {sup 99m}Tc{sub D}TPA and {sup 99m}Tc-DMSA constitute about 18% of pediatric diagnostic procedures. A retrospective non-randomized study was conducted in 2010, for absolute quantification of kidney activities. In 2010,51 patients underwent renal studies in the Hospital of the Rio de Janeiro State University - HUPE-UERJ/ RJ, Brazil. 19 of them with 9±4 years of age and body mass of 31.8±20.8 kg showed relative uptake of {sup 99m}Tc-DMSA between 45% and 55%. Still images (AP, PA and posterior oblique abdomen incidences) were acquired 4 h after intravenous administration of 115.69±42.31 MBq of {sup 99m}Tc-DMSA using gamma camera (Siemens E-Cam), LEHR collimator, matrix of 256x256 and 5min imaging. In 2012, 3 patients (9.3±2.1 years, 31.97±10.75 kg) in the previous study were followed in a prospective study. All urinary excretions samples were collected from administration of {sup 99m}Tc-DMSA to 6 h after, while simultaneously images were acquired AP and PA abdominal region with Philips model Picker Prism 2000XP. Aliquots of each urine sample were measured in gamma counter shaft GenesysTM Gamma 1 with Nal (TI) detector. For whole body, the biological half-life estimate was 11.0±2.0 h, and the residence time was found to be 5.6±0.4 h while the literature suggests 4.l±0.5 h for age range studied. Residence time for kidney was found to be 0.7±0.4 h, while the literature shows, 3.07 h and 1.4 h for patients with normal and renal pathologies, respectively. This difference may be attributed to the methodology because while the images were taken during the first 6 h, SMITH et aI. (1996) performed images of the kidneys and whole body 30 h after administration of 99mTc{sub D}MSA, incorporating the slow term of biological half-life. For liver, it was found the average residence time of 3.0±0.4 min, whereas the literature indicates 20.8 min and 25.1 min, respectively according to SMITH et. ai (1996) and ICRP (1998). The fact that the administered activity was higher than the activity estimated by 3 different criteria is not a single parameter to be considered for the optimization of doses, once for diagnostic image quality it must be ensured. Therefore, the analysis of the quality of the images should be part of the study. It is recommended to include in the study protocol whole body images on the first day and 24 h after administration of {sup 99m}Tc-DMSA. To quantify the activity in the whole body, it is recommended to perform the patient attenuation map through an emission image. For organ images, it is recommended to use physical simulator to obtain the calibration factor of the respective body. The acquisition time of the images should follow the estimated time for the biological half-life of 2 terms (fast and slow). (author)

  8. Biokinetics of dietary RRR-alpha-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E. Evidence that vitamin C does not spare vitamin E in vivo

    International Nuclear Information System (INIS)

    Burton, G.W.; Wronska, U.; Stone, L.; Foster, D.O.; Ingold, K.U.

    1990-01-01

    The net rates of uptake of new and loss of old 2R,4'R,8'R-alpha-tocopherol (RRR-alpha-TOH) have been measured in the blood and in nine tissues of male guinea pigs over an eight week period by feeding diets containing deuterium-labelled alpha-tocopheryl acetate (d6-RRR-alpha-TOAc). There was an initial two week lead-in period during which 24 animals [the high vitamin E (HE) group] received diets containing 36 mg of unlabelled (d0) RRR-alpha-TOAc and 250 mg of ascorbic acid per kg diet, while another 24 animals [the low vitamin E (LE) group] received diets containing 5 mg d0-RRR-alpha-TOAc and 250 mg ascorbic acid per kg diet. The HE group was then divided into three equal subgroups, which were fed diets containing 36 mg d6-RRR-alpha-TOAc and 5000 mg [the high vitamin C (HEHC) subgroup], 250 mg [the normal vitamin C (HENC) subgroup] and 50 mg [the low vitamin C (HELC) subgroup] ascorbic acid per kg diet. One animal from each group was sacrificed each week and the blood and tissues were analyzed for d0- and d6-RRR-alpha-TOH by gas chromatography-mass spectrometry. The LE group was similarly divided into three equal subgroups with animals receiving diets containing 5 mg d6-RRR-alpha-TOAc and 5,000 mg (LEHC), 250 mg (LENC) and 50 mg (LELC) ascorbic acid per kg diet with a similar protocol being followed for sacrifice and analyses. In the HE group the total (d0(-) + d6-) RRR-alpha-TOH concentrations in blood and tissues remained essentially constant over the eight week experiment, whereas in the LE group the total RRR-alpha-TOH concentrations declined noticeably. There were no significant differences in the concentrations of old d0-RRR-alpha-TOH nor in the concentrations of new d6-RRR-alpha-TOH found in any tissue at a particular time between the HEHC, HENC and HELC subgroups, nor between the LEHC, LENC and LELC subgroups

  9. Microlaser-based displays

    Science.gov (United States)

    Bergstedt, Robert; Fink, Charles G.; Flint, Graham W.; Hargis, David E.; Peppler, Philipp W.

    1997-07-01

    Laser Power Corporation has developed a new type of projection display, based upon microlaser technology and a novel scan architecture, which provides the foundation for bright, extremely high resolution images. A review of projection technologies is presented along with the limitations of each and the difficulties they experience in trying to generate high resolution imagery. The design of the microlaser based projector is discussed along with the advantage of this technology. High power red, green, and blue microlasers have been designed and developed specifically for use in projection displays. These sources, in combination with high resolution, high contrast modulator, produce a 24 bit color gamut, capable of supporting the full range of real world colors. The new scan architecture, which reduces the modulation rate and scan speeds required, is described. This scan architecture, along with the inherent brightness of the laser provides the fundamentals necessary to produce a 5120 by 4096 resolution display. The brightness and color uniformity of the display is excellent, allowing for tiling of the displays with far fewer artifacts than those in a traditionally tiled display. Applications for the display include simulators, command and control centers, and electronic cinema.

  10. SPACE BASED INTERCEPTOR SCALING

    Energy Technology Data Exchange (ETDEWEB)

    G. CANAVAN

    2001-02-01

    Space Based Interceptor (SBI) have ranges that are adequate to address rogue ICBMs. They are not overly sensitive to 30-60 s delay times. Current technologies would support boost phase intercept with about 150 interceptors. Higher acceleration and velocity could reduce than number by about a factor of 3 at the cost of heavier and more expensive Kinetic Kill Vehicles (KKVs). 6g SBI would reduce optimal constellation costs by about 35%; 8g SBI would reduce them another 20%. Interceptor ranges fall rapidly with theater missile range. Constellations increase significantly for ranges under 3,000 km, even with advanced interceptor technology. For distributed launches, these estimates recover earlier strategic scalings, which demonstrate the improved absentee ratio for larger or multiple launch areas. Constellations increase with the number of missiles and the number of interceptors launched at each. The economic estimates above suggest that two SBI per missile with a modest midcourse underlay is appropriate. The SBI KKV technology would appear to be common for space- and surface-based boost phase systems, and could have synergisms with improved midcourse intercept and discrimination systems. While advanced technology could be helpful in reducing costs, particularly for short range theater missiles, current technology appears adequate for pressing rogue ICBM, accidental, and unauthorized launches.

  11. Location-based games

    DEFF Research Database (Denmark)

    Ejsing-Duun, Stine

    In this dissertation, it is explored which prerequisites are necessary in location-based games (LBGs) to make meaningful the meeting between players and spatiality with an emphasis on physical locations. Throughout the dissertation, it has been shown that LBGs affect players’ perception of and be......In this dissertation, it is explored which prerequisites are necessary in location-based games (LBGs) to make meaningful the meeting between players and spatiality with an emphasis on physical locations. Throughout the dissertation, it has been shown that LBGs affect players’ perception...... of and behavior in everyday spaces, as the games reside on the boundaries between the continuums of play and ordinary, authentic and fictional, and as they merge physical and digital media. These are termed the six dimensions of LBGs. LBGs let the player explore the boundaries between these dimensions...... experiences of being in the world and the creation of meaning. The theory on motivation defines what motivation consists of and how it relates to our actions. This theory has been combined with theories concerning play and play culture, digital media, (digital) games, (optimal) experiences, landscape...

  12. DVD Based Electronic Pulser

    International Nuclear Information System (INIS)

    Morris, Scott J.; Pratt, Rick M.; Hughes, Michael A.; Kouzes, Richard T.; Pitts, W K.; Robinson, Eric E.

    2005-01-01

    This paper describes the design, construction, and testing of a DVD based electronic pulser system (DVDEPS). Such a device is used to generate pulse streams for simulation of both gamma and neutron detector systems. The DVDEPS reproduces a random pulse stream of a full HPGe spectrum as well as a digital pulse stream representing the output of a neutron multiplicity detector. The exchangeable DVD media contains over an hour of data for both detector systems and can contain an arbitrary gamma spectrum and neutron pulse stream. The data is written to the DVD using a desktop computer program from either actual or simulated spectra. The targeted use of the DVDEPS is authentication or validation of monitoring equipment for non-proliferation purposes, but it is also of general use whenever a complex data stream is required. The DVD based pulser combines the storage capacity and simplicity of DVD technology with commonly available electronic components to build a relatively inexpensive yet highly capable testing instrument

  13. Metasurface-Based Polarimeters

    Directory of Open Access Journals (Sweden)

    Fei Ding

    2018-04-01

    Full Text Available The state of polarization (SOP is an inherent property of light that can be used to gain crucial information about the composition and structure of materials interrogated with light. However, the SOP is difficult to experimentally determine since it involves phase information between orthogonal polarization states, and is uncorrelated with the light intensity and frequency, which can be easily determined with photodetectors and spectrometers. Rapid progress on optical gradient metasurfaces has resulted in the development of conceptually new approaches to the SOP characterization. In this paper, we review the fundamentals of and recent developments within metasurface-based polarimeters. Starting by introducing the concepts of generalized Snell’s law and Stokes parameters, we explain the Pancharatnam–Berry phase (PB-phase which is instrumental for differentiating between orthogonal circular polarizations. Then we review the recent progress in metasurface-based polarimeters, including polarimeters, spectropolarimeters, orbital angular momentum (OAM spectropolarimeters, and photodetector integrated polarimeters. The review is ended with a short conclusion and perspective for future developments.

  14. [Competence based medical education].

    Science.gov (United States)

    Bernabó, Jorge G; Buraschi, Jorge; Olcese, Juan; Buraschi, María; Duro, Eduardo

    2007-01-01

    The strategy of curriculum planning in the majority of the Schools of Medicine has shifted, in the past years, from curriculum models based in contents to outcome oriented curricula. Coincidently the interest in defining and evaluating the clinical competences that a graduate must have has grown. In our country, and particularly in the Associated Hospitals belonging to the Unidad Regional de Enseñanza IV of the UBA School of Medicine, evidence has been gathered showing that the acquisition of clinical competences during the grade is in general insufficient. The foundations and characteristics of PREM (Programa de Requisitos Esenciales Mínimos) are described. PREM is a tool to promote the apprenticeship of abilities and necessary skills for the practice of medicine. The objective of the program is to promote the apprenticeship of a well defined list of core competences considered indispensable for a general practitioner. An outcome oriented curriculum with a clear definition of the expected knowledge, skills and attitudes of a graduate of the programme, the promotion of learning experiences centered in the practice and evaluation tools based in direct observation of the student's performance should contribute to close the gap between what the Medicine Schools traditionally teach and evaluate, and what the doctor needs to know and needs to do to perform correctly its profession.

  15. Challenge Based Innovation gala

    CERN Multimedia

    CERN. Geneva; Utriainen, Tuuli Maria; Toivonen, Harri; Nordberg, Markus

    2014-01-01

    Challenge Based Innovation gala   There’s a new experiment starting in CERN called IdeaLab where we work together with detector R&D researchers to help them to bridge their knowledge into a more human, societally oriented context. Currently we are located in B153, but will move our activities to a new facility next to the Globe in May 2014. One of our first pilot projects is a 5 month course CBI (Challenge Based Innovation) where two multidisciplinary student teams join forces with Edusafe & TALENT projects at CERN. Their goal is to discover what kind of tools for learning could be created in collaboration with the two groups. After months of user interviews and low resolution prototyping they are ready to share the results with us in the form of an afternoon gala. We warmly welcome you to join us to see the students' results and experience the prototypes they have conceived. The event is in three parts, you are welcome to visit all of them,...

  16. Model Based Definition

    Science.gov (United States)

    Rowe, Sidney E.

    2010-01-01

    In September 2007, the Engineering Directorate at the Marshall Space Flight Center (MSFC) created the Design System Focus Team (DSFT). MSFC was responsible for the in-house design and development of the Ares 1 Upper Stage and the Engineering Directorate was preparing to deploy a new electronic Configuration Management and Data Management System with the Design Data Management System (DDMS) based upon a Commercial Off The Shelf (COTS) Product Data Management (PDM) System. The DSFT was to establish standardized CAD practices and a new data life cycle for design data. Of special interest here, the design teams were to implement Model Based Definition (MBD) in support of the Upper Stage manufacturing contract. It is noted that this MBD does use partially dimensioned drawings for auxiliary information to the model. The design data lifecycle implemented several new release states to be used prior to formal release that allowed the models to move through a flow of progressive maturity. The DSFT identified some 17 Lessons Learned as outcomes of the standards development, pathfinder deployments and initial application to the Upper Stage design completion. Some of the high value examples are reviewed.

  17. Constraint-based reachability

    Directory of Open Access Journals (Sweden)

    Arnaud Gotlieb

    2013-02-01

    Full Text Available Iterative imperative programs can be considered as infinite-state systems computing over possibly unbounded domains. Studying reachability in these systems is challenging as it requires to deal with an infinite number of states with standard backward or forward exploration strategies. An approach that we call Constraint-based reachability, is proposed to address reachability problems by exploring program states using a constraint model of the whole program. The keypoint of the approach is to interpret imperative constructions such as conditionals, loops, array and memory manipulations with the fundamental notion of constraint over a computational domain. By combining constraint filtering and abstraction techniques, Constraint-based reachability is able to solve reachability problems which are usually outside the scope of backward or forward exploration strategies. This paper proposes an interpretation of classical filtering consistencies used in Constraint Programming as abstract domain computations, and shows how this approach can be used to produce a constraint solver that efficiently generates solutions for reachability problems that are unsolvable by other approaches.

  18. Skull base tumor model.

    Science.gov (United States)

    Gragnaniello, Cristian; Nader, Remi; van Doormaal, Tristan; Kamel, Mahmoud; Voormolen, Eduard H J; Lasio, Giovanni; Aboud, Emad; Regli, Luca; Tulleken, Cornelius A F; Al-Mefty, Ossama

    2010-11-01

    Resident duty-hours restrictions have now been instituted in many countries worldwide. Shortened training times and increased public scrutiny of surgical competency have led to a move away from the traditional apprenticeship model of training. The development of educational models for brain anatomy is a fascinating innovation allowing neurosurgeons to train without the need to practice on real patients and it may be a solution to achieve competency within a shortened training period. The authors describe the use of Stratathane resin ST-504 polymer (SRSP), which is inserted at different intracranial locations to closely mimic meningiomas and other pathological entities of the skull base, in a cadaveric model, for use in neurosurgical training. Silicone-injected and pressurized cadaveric heads were used for studying the SRSP model. The SRSP presents unique intrinsic metamorphic characteristics: liquid at first, it expands and foams when injected into the desired area of the brain, forming a solid tumorlike structure. The authors injected SRSP via different passages that did not influence routes used for the surgical approach for resection of the simulated lesion. For example, SRSP injection routes included endonasal transsphenoidal or transoral approaches if lesions were to be removed through standard skull base approach, or, alternatively, SRSP was injected via a cranial approach if the removal was planned to be via the transsphenoidal or transoral route. The model was set in place in 3 countries (US, Italy, and The Netherlands), and a pool of 13 physicians from 4 different institutions (all surgeons and surgeons in training) participated in evaluating it and provided feedback. All 13 evaluating physicians had overall positive impressions of the model. The overall score on 9 components evaluated--including comparison between the tumor model and real tumor cases, perioperative requirements, general impression, and applicability--was 88% (100% being the best possible

  19. Space-Based Range

    Science.gov (United States)

    2008-01-01

    Space-Based Range (SBR), previously known as Space-Based Telemetry and Range Safety (STARS), is a multicenter NASA proof-of-concept project to determine if space-based communications using NASA's Tracking and Data Relay Satellite System (TDRSS) can support the Range Safety functions of acquiring tracking data and generating flight termination signals, while also providing broadband Range User data such as voice, video, and vehicle/payload data. There was a successful test of the Range Safety system at Wallops Flight Facility (WFF) on December 20, 2005, on a two-stage Terrier-Orion spin-stabilized sounding rocket. SBR transmitted GPS tracking data and maintained links with two TDRSS satellites simultaneously during the 10-min flight. The payload section deployed a parachute, landed in the Atlantic Ocean about 90 miles downrange from the launch site, and was successfully recovered. During the Terrier-Orion tests flights, more than 99 percent of all forward commands and more than 95 percent of all return frames were successfully received and processed. The time latency necessary for a command to travel from WFF over landlines to White Sands Complex and then to the vehicle via TDRSS, be processed onboard, and then be sent back to WFF was between 1.0 s and 1.1 s. The forward-link margins for TDRS-10 (TDRS East [TDE]) were 11 dB to 12 dB plus or minus 2 dB, and for TDRS-4 (TDRS Spare [TDS]) were 9 dB to 10 dB plus or minus 1.5 dB. The return-link margins for both TDE and TDS were 6 dB to 8 dB plus or minus 3 dB. There were 11 flights on an F-15B at Dryden Flight Research Center (DFRC) between November 2006 and February 2007. The Range User system tested a 184-element TDRSS Ku-band (15 GHz) phased-array antenna with data rates of 5 Mbps and 10 Mbps. This data was a combination of black-and-white cockpit video, Range Safety tracking and transceiver data, and aircraft and antenna controller data streams. IP data formatting was used.

  20. Absorbed Doses to Patients in Nuclear Medicine

    International Nuclear Information System (INIS)

    Leide-Svegborn, Sigrid; Mattsson, Soeren; Nosslin, Bertil; Johansson, Lennart

    2004-09-01

    The work with a Swedish catalogue of radiation absorbed doses to patients undergoing nuclear medicine investigations has continued. After the previous report in 1999, biokinetic data and dose estimates (mean absorbed dose to various organs and tissues and effective dose) have been produced for a number of substances: 11 C- acetate, 11 C- methionine, 18 F-DOPA, whole antibody labelled with either 99m Tc, 111 In, 123 I or 131 I, fragment of antibody, F(ab') 2 labelled with either 99m Tc, 111 In, 123 I or 131 I and fragment of antibody, Fab' labelled with either 99m Tc, 111 In, 123 I or 131 I. The absorbed dose estimates for these substances have been made from published biokinetic information. For other substances of interest, e.g. 14 C-urea (children age 3-6 years), 14 C-glycocholic acid, 14 C-xylose and 14 C-triolein, sufficient literature data have not been available. Therefore, a large number of measurements on patients and volunteers have been carried out, in order to determine the biokinetics and dosimetry for these substances. Samples of breast milk from 50 mothers, who had been subject to nuclear medicine investigations, have been collected at various times after administration of the radiopharmaceutical to the mother. The activity concentration in the breast milk samples has been measured. The absorbed dose to various organs and tissues and the effective dose to the child who ingests the milk have been determined for 17 different radiopharmaceuticals. Based on these results revised recommendations for interruption of breast-feeding after nuclear medicine investigations are suggested

  1. Absorbed Doses to Patients in Nuclear Medicine; Doskatalogen foer nukleaermedicin

    Energy Technology Data Exchange (ETDEWEB)

    Leide-Svegborn, Sigrid; Mattsson, Soeren; Nosslin, Bertil [Universitetssjukhuset MAS, Malmoe (Sweden). Avd. foer radiofysik; Johansson, Lennart [Norrlands Universitetssjukhus, Umeaa (Sweden). Avd. foer radiofysik

    2004-09-01

    The work with a Swedish catalogue of radiation absorbed doses to patients undergoing nuclear medicine investigations has continued. After the previous report in 1999, biokinetic data and dose estimates (mean absorbed dose to various organs and tissues and effective dose) have been produced for a number of substances: {sup 11}C- acetate, {sup 11}C- methionine, {sup 18}F-DOPA, whole antibody labelled with either {sup 99m}Tc, {sup 111}In, {sup 123}I or {sup 131}I, fragment of antibody, F(ab'){sub 2} labelled with either {sup 99m}Tc, {sup 111}In, {sup 123}I or {sup 131}I and fragment of antibody, Fab' labelled with either {sup 99m}Tc, {sup 111}In, {sup 123}I or {sup 131}I. The absorbed dose estimates for these substances have been made from published biokinetic information. For other substances of interest, e.g. {sup 14}C-urea (children age 3-6 years), {sup 14}C-glycocholic acid, {sup 14}C-xylose and {sup 14}C-triolein, sufficient literature data have not been available. Therefore, a large number of measurements on patients and volunteers have been carried out, in order to determine the biokinetics and dosimetry for these substances. Samples of breast milk from 50 mothers, who had been subject to nuclear medicine investigations, have been collected at various times after administration of the radiopharmaceutical to the mother. The activity concentration in the breast milk samples has been measured. The absorbed dose to various organs and tissues and the effective dose to the child who ingests the milk have been determined for 17 different radiopharmaceuticals. Based on these results revised recommendations for interruption of breast-feeding after nuclear medicine investigations are suggested.

  2. Touching base with OPERA

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    Three seminars – at CERN, at Gran Sasso and in Japan – and an article calling for the scrutiny of the scientific community: the OPERA Collaboration opened its research publicly. In addition to huge press coverage, this triggered welcome reactions from colleagues around the world, many of whom will attempt to independently interpret and reproduce the measurement. OPERA’s Spokesperson touches base with the Bulletin.   The CERN Main Auditorium was crowded as OPERA Physics co-ordinator Dario Autiero presented the results of their research (23 September 2011). According to the OPERA strategy, the results of the measurements are in the hands of the scientific community and, as for any other scientific result, several months will be needed before other groups will be able to perform an independent measurement. In the meantime, the OPERA Collaboration is dealing with an avalanche of emails from the scientific community, members of the general public, and the press. &...

  3. Bases para proyectiles dirigidos

    Directory of Open Access Journals (Sweden)

    Editorial, Equipo

    1959-03-01

    Full Text Available Aunque actualmente no se ha llegado a una línea general de métodos o sistemas que gobiernen un tipo característico de rampa y servicios auxiliares necesarios para el lanzamiento al espacio de proyectiles dirigidos a grandes alturas y distancias, las experiencias obtenidas en diferentes ensayos, utilizando distintos tipos de proyectiles y trayectorias balísticas, han sentado toda una serie de procedimientos, datos y conclusiones de gran valor balístico que, aun teniendo en cuenta la continua evolución del proyectil, sus formas, combustibles y alcances, se conocen ya, con bastante aproximación, las condiciones mínimas que ha de reunir una base dedicada a este tipo de lanzamientos.

  4. Rate based failure detection

    Science.gov (United States)

    Johnson, Brett Emery Trabun; Gamage, Thoshitha Thanushka; Bakken, David Edward

    2018-01-02

    This disclosure describes, in part, a system management component and failure detection component for use in a power grid data network to identify anomalies within the network and systematically adjust the quality of service of data published by publishers and subscribed to by subscribers within the network. In one implementation, subscribers may identify a desired data rate, a minimum acceptable data rate, desired latency, minimum acceptable latency and a priority for each subscription. The failure detection component may identify an anomaly within the network and a source of the anomaly. Based on the identified anomaly, data rates and or data paths may be adjusted in real-time to ensure that the power grid data network does not become overloaded and/or fail.

  5. Behavior based safety

    International Nuclear Information System (INIS)

    Sudhikumaran, T.V.; Mehta, S.C.; Goyal, D.K.

    2009-01-01

    Behaviour Based Safety (popularly known as BBS) is a new methodology for achieving injury free work place and total Safety Culture. BBS is successfully being implemented and is being practiced as a work methodology for achieving a loss and injury free work environment and work practice. Through BBS, it was brought out that the root causes of all Industrial accidents some how originate from the 'at risk' behaviour of some individual or group of individuals at some level. The policy of NPCIL is to excel in the field of Industrial and Fire Safety in comparison to international standards. This article indents to bring out the various parameters helping in installing BBS programme at any plant. (author)

  6. Fuel cycle based safeguards

    International Nuclear Information System (INIS)

    De Montmollin, J.M.; Higinbotham, W.A.; Gupta, D.

    1985-07-01

    In NPT safeguards the same model approach and absolute-quantity inspection goals are applied at present to all similar facilities, irrespective of the State's fuel cycle. There is a continuing interest and activity on the part of the IAEA in new NPT safeguards approaches that more directly address a State's nuclear activities as a whole. This fuel cycle based safeguards system is expected to a) provide a statement of findings for the entire State rather than only for individual facilities; b) allocate inspection efforts so as to reflect more realistically the different categories of nuclear materials in the different parts of the fuel cycle and c) provide more timely and better coordinated information on the inputs, outputs and inventories of nuclear materials in a State. (orig./RF) [de

  7. Integrated data base program

    International Nuclear Information System (INIS)

    Notz, K.J.

    1981-01-01

    The IDB Program provides direct support to the DOE Nuclear Waste Management and Fuel Cycle Programs and their lead sites and support contractors by providing and maintaining a current, integrated data base of spent fuel and radioactive waste inventories and projections. All major waste types (HLW, TRU, and LLW) and sources (government, commerical fuel cycle, and I/I) are included. A major data compilation was issued in September, 1981: Spent Fuel and Radioactive Waste Inventories and Projections as of December 31, 1980, DOE/NE-0017. This report includes chapters on Spent Fuel, HLW, TRU Waste, LLW, Remedial Action Waste, Active Uranium Mill Tailings, and Airborne Waste, plus Appendices with more detailed data in selected areas such as isotopics, radioactivity, thermal power, projections, and land usage. The LLW sections include volumes, radioactivity, thermal power, current inventories, projected inventories and characteristics, source terms, land requirements, and a breakdown in terms of government/commercial and defense/fuel cycle/I and I

  8. Space-based detectors

    DEFF Research Database (Denmark)

    Sesana, A.; Weber, W. J.; Killow, C. J.

    2014-01-01

    ) is planned for 2015. This mission and its payload “LISA Technology Package” will demonstrate key technologies for LISA. In this context, reference masses in free fall for LISA, and gravitational physics in general, was described by William Weber, laser interferometry at the pico-metre level and the optical......The parallel session C5 on Space-Based Detectors gave a broad overview over the planned space missions related to gravitational wave detection. Overviews of the revolutionary science to be expected from LISA was given by Alberto Sesana and Sasha Buchman. The launch of LISA Pathfinder (LPF...... bench of LPF was presented by Christian Killow and the performance of the LPF optical metrology system by Paul McNamara. While LPF will not yet be sensitive to gravitational waves, it may nevertheless be used to explore fundamental physics questions, which was discussed by Michele Armano. Some parts...

  9. Base isolation: Fresh insight

    Energy Technology Data Exchange (ETDEWEB)

    Shustov, V.

    1993-07-15

    The objective of the research is a further development of the engineering concept of seismic isolation. Neglecting the transient stage of seismic loading results in a widespread misjudgement: The force of resistance associated with velocity is mostly conceived as a source of damping vibrations, though it is an active force at the same time, during an earthquake type excitation. For very pliant systems such as base isolated structures with relatively low bearing stiffness and with artificially added heavy damping mechanism, the so called `damping`` force may occur even the main pushing force at an earthquake. Thus, one of the two basic pillars of the common seismic isolation philosophy, namely, the doctrine of usefulness and necessity of a strong damping mechanism, is turning out to be a self-deception, sometimes even jeopardizing the safety of structures and discrediting the very idea of seismic isolation. There is a way out: breaking with damping dependancy.

  10. Transaction based approach

    Science.gov (United States)

    Hunka, Frantisek; Matula, Jiri

    2017-07-01

    Transaction based approach is utilized in some methodologies in business process modeling. Essential parts of these transactions are human beings. The notion of agent or actor role is usually used for them. The paper on a particular example describes possibilities of Design Engineering Methodology for Organizations (DEMO) and Resource-Event-Agent (REA) methodology. Whereas the DEMO methodology can be regarded as a generic methodology having its foundation in the theory of Enterprise Ontology the REA methodology is regarded as the domain specific methodology and has its origin in accountancy systems. The results of these approaches is that the DEMO methodology captures everything that happens in the reality with a good empirical evidence whereas the REA methodology captures only changes connected with economic events. Economic events represent either change of the property rights to economic resource or consumption or production of economic resources. This results from the essence of economic events and their connection to economic resources.

  11. Mucin-Based Vaccines

    Science.gov (United States)

    Richardson, Jonathan P.; MacMillan, Derek

    Mucins are heavily O-glycosylated cell surface and secreted glycoproteins . In addition to orchestrating cell-extracellular matrix and cell-cell interactions in healthy organisms mucins are also the major carriers of altered glycosylation in carcinomas. Tumor-associated antigens displayed by cancer cells comprise oligosaccharide and glycopeptide motifs not encountered in the same locale or at the same frequency in healthy cells, and potentially confer a selective advantage to the tumor. Frequently tumor-associated antigens are under-glycosylated and prematurely sialylated, and it is these relatively simple saccharide and glycopeptide structures that have been targeted to serve as drug candidates in most cases. A major goal is to assemble glycopeptide vaccine candidates based on partial mucin sequences and displaying tumor-associated antigens that can mount a potent immunological tumor-specific response when, in reality, the tumor has already coerced the immune system into a state of co-existence.

  12. Cellular based cancer vaccines

    DEFF Research Database (Denmark)

    Hansen, M; Met, Ö; Svane, I M

    2012-01-01

    -associated antigens introduced to dendritic cells (DCs) generated in vitro. This may in part result from suboptimal maturation of DCs leading to insufficient production of IL-12, a key driver of cellular immunity. Therefore, tremendous efforts have been put into the design of maturation cocktails that are able...... of tolerogenic molecules and activation-induced dendritic cell death should be avoided. Thus, compounds such as IFN-γ may initially induce immunity but later on tolerance. Maturation with PGE(2) obviously promotes migration via expression of CCR7 but on the down side PGE(2) limits the production of IL-12...... to transiently affect in vitro migration via autocrine receptor-mediated endocytosis of CCR7. In the current review, we discuss optimal design of DC maturation focused on pre-clinical as well as clinical results from standard and polarized dendritic cell based cancer vaccines....

  13. PROBLEM-BASED LEARNING

    Directory of Open Access Journals (Sweden)

    David Esema

    2012-12-01

    Full Text Available Problem-Based Learning (PBL, adalah model pembelajaran yang awalnya dikembangkan di dunia pendidikan medis, namun kini telah digunakan secara luas di berbagai jenjang dan bidang pendidikan. Basis teortits dari PBL adalah kolaborativisme dan konstruktivisme. Kemitraan, keterbukaan dan kejujuran, rasa hormat, dan kepercayaan menjadi nilai-nilai yang mendasari dan sekaligus menjadi prasyarat bagi keberhasilan PBL Sintaks PBL meliputi: pengenalan dan pemahaman konsep dasar, eksplorasi fakta dan informasi relevan secara mandiri, bertukar pemahaman dalam kelompok/kelas, kesimpulan dan evaluasi. Beberapa riset mengenai PBL baik di luar maupun di dalam negeri yang dipaparkan dan dibandingkan dalam tulisan ini menunjukkan data tentang efektifitas PBL dalam kegiatan pembelajaran.

  14. Graphene based biosensors

    Energy Technology Data Exchange (ETDEWEB)

    Gürel, Hikmet Hakan, E-mail: hhakan.gurel@kocaeli.edu.tr [Kocaeli University, Kocaeli (Turkey); Salmankurt, Bahadır [Sakarya University, Sakarya (Turkey)

    2016-03-25

    Nanometer-sized graphene as a 2D material has unique chemical and electronic properties. Because of its unique physical, chemical, and electronic properties, its interesting shape and size make it a promising nanomaterial in many biological applications. It is expected that biomaterials incorporating graphene will be developed for the graphene-based drug delivery systems and biomedical devices. The interactions of biomolecules and graphene are long-ranged and very weak. Development of new techniques is very desirable for design of bioelectronics sensors and devices. In this work, we present first-principles calculations within density functional theory to calculate effects of charging on nucleobases on graphene. It is shown that how modify structural and electronic properties of nucleobases on graphene by applied charging.

  15. Liaison based assembly design

    Energy Technology Data Exchange (ETDEWEB)

    Ames, A.; Kholwadwala, D.; Wilson, R.H.

    1996-12-01

    Liaison Based Assembly Design extends the current information infrastructure to support design in terms of kinematic relationships between parts, or liaisons. These liaisons capture information regarding contact, degrees-of-freedom constraints and containment relationships between parts in an assembly. The project involved defining a useful collection of liaison representations, investigating their properties, and providing for maximum use of the data in downstream applications. We tested our ideas by implementing a prototype system involving extensions to Pro/Engineer and the Archimedes assembly planner. With an expanded product model, the design system is more able to capture design intent. When a product update is attempted, increased knowledge availability improves our ability to understand the effect of design changes. Manufacturing and analysis disciplines benefit from having liaison information available, so less time is wasted arguing over incomplete design specifications and our enterprise can be more completely integrated.

  16. Lunar based massdriver applications

    Science.gov (United States)

    Ehresmann, Manfred; Gabrielli, Roland Atonius; Herdrich, Georg; Laufer, René

    2017-05-01

    The results of a lunar massdriver mission and system analysis are discussed and show a strong case for a permanent lunar settlement with a site near the lunar equator. A modular massdriver concept is introduced, which uses multiple acceleration modules to be able to launch large masses into a trajectory that is able to reach Earth. An orbital mechanics analysis concludes that the launch site will be in the Oceanus Procellarum a flat, Titanium rich lunar mare area. It is further shown that the bulk of massdriver components can be manufactured by collecting lunar minerals, which are broken down into its constituting elements. The mass to orbit transfer rates of massdriver case study are significant and can vary between 1.8 kt and 3.3 megatons per year depending on the available power. Thus a lunar massdriver would act as a catalyst for any space based activities and a game changer for the scale of feasible space projects.

  17. Model Based Temporal Reasoning

    Science.gov (United States)

    Rabin, Marla J.; Spinrad, Paul R.; Fall, Thomas C.

    1988-03-01

    Systems that assess the real world must cope with evidence that is uncertain, ambiguous, and spread over time. Typically, the most important function of an assessment system is to identify when activities are occurring that are unusual or unanticipated. Model based temporal reasoning addresses both of these requirements. The differences among temporal reasoning schemes lies in the methods used to avoid computational intractability. If we had n pieces of data and we wanted to examine how they were related, the worst case would be where we had to examine every subset of these points to see if that subset satisfied the relations. This would be 2n, which is intractable. Models compress this; if several data points are all compatible with a model, then that model represents all those data points. Data points are then considered related if they lie within the same model or if they lie in models that are related. Models thus address the intractability problem. They also address the problem of determining unusual activities if the data do not agree with models that are indicated by earlier data then something out of the norm is taking place. The models can summarize what we know up to that time, so when they are not predicting correctly, either something unusual is happening or we need to revise our models. The model based reasoner developed at Advanced Decision Systems is thus both intuitive and powerful. It is currently being used on one operational system and several prototype systems. It has enough power to be used in domains spanning the spectrum from manufacturing engineering and project management to low-intensity conflict and strategic assessment.

  18. DNA-based machines.

    Science.gov (United States)

    Wang, Fuan; Willner, Bilha; Willner, Itamar

    2014-01-01

    The base sequence in nucleic acids encodes substantial structural and functional information into the biopolymer. This encoded information provides the basis for the tailoring and assembly of DNA machines. A DNA machine is defined as a molecular device that exhibits the following fundamental features. (1) It performs a fuel-driven mechanical process that mimics macroscopic machines. (2) The mechanical process requires an energy input, "fuel." (3) The mechanical operation is accompanied by an energy consumption process that leads to "waste products." (4) The cyclic operation of the DNA devices, involves the use of "fuel" and "anti-fuel" ingredients. A variety of DNA-based machines are described, including the construction of "tweezers," "walkers," "robots," "cranes," "transporters," "springs," "gears," and interlocked cyclic DNA structures acting as reconfigurable catenanes, rotaxanes, and rotors. Different "fuels", such as nucleic acid strands, pH (H⁺/OH⁻), metal ions, and light, are used to trigger the mechanical functions of the DNA devices. The operation of the devices in solution and on surfaces is described, and a variety of optical, electrical, and photoelectrochemical methods to follow the operations of the DNA machines are presented. We further address the possible applications of DNA machines and the future perspectives of molecular DNA devices. These include the application of DNA machines as functional structures for the construction of logic gates and computing, for the programmed organization of metallic nanoparticle structures and the control of plasmonic properties, and for controlling chemical transformations by DNA machines. We further discuss the future applications of DNA machines for intracellular sensing, controlling intracellular metabolic pathways, and the use of the functional nanostructures for drug delivery and medical applications.

  19. Organic Biochar Based Fertilization

    Science.gov (United States)

    Schmidt, Hans-Peter; Pandit, Bishnu Hari; Cornelissen, Gerard; Kammann, Claudia

    2017-04-01

    Biochar produced in cost-efficient flame curtain kilns (Kon-Tiki) was nutrient enriched either with cow urine or with dissolved mineral (NPK) fertilizer to produce biochar-based fertilizers containing between 60-100 kg N, 5-60 kg P2O5 and 60-100 kg K2O, respectively, per ton of biochar. In 21 field trials nutrient-enriched biochars were applied at rates of 0.5 to 2 t ha-1 into the root zone of 13 different annual and perennial crops. Treatments combining biochar, compost and organic or chemical fertilizer were evaluated; control treatments contained the same amounts of nutrients but without biochar. All nutrient-enriched biochar substrates improved yields compared to their respective no-biochar controls. Biochar enriched with dissolved NPK produced on average 20% ± 5.1% (N=4) higher yields than standard NPK fertilization without biochar. Cow urine-enriched biochar blended with compost resulted on average in 123% ± 76.7% (N=13) higher yields compared to the organic farmer practice with cow urine-blended compost and outcompeted NPK-enriched biochar (same nutrient dose) by 103% ± 12.4% (N=4) on average. 21 field trials robustly revealed that low-dosage root zone application of organic biochar-based fertilizers caused substantial yield increases in rather fertile silt loam soils compared to traditional organic fertilization and to mineral NPK- or NPK-biochar fertilization. This can likely be explained by the nutrient carrier effect of biochar causing a slow nutrient release behavior, more balanced nutrient fluxes and reduced nutrient losses especially when liquid organic nutrients are used for the biochar enrichment. The results promise new pathways for optimizing organic farming and improving on-farm nutrient cycling.

  20. Mainstreaming gesture based interfaces

    Directory of Open Access Journals (Sweden)

    David Procházka

    2013-01-01

    Full Text Available Gestures are a common way of interaction with mobile devices. They emerged especially with the iPhone production. Gestures in currently used devices are usually based on the original gestures presented by Apple in its iOS (iPhone Operating System. Therefore, there is a wide agreement on the mobile gesture design. In last years, it is possible to see experiments with gesture usage also in the other areas of consumer electronics and computers. The examples can include televisions, large projections etc. These gestures can be marked as spatial or 3D gestures. They are connected with a natural 3D environment rather than with a flat 2D screen. Nevertheless, it is hard to find a comparable design agreement within the spatial gestures. Various projects are based on completely different gesture sets. This situation is confusing for their users and slows down spatial gesture adoption.This paper is focused on the standardization of spatial gestures. The review of projects focused on spatial gesture usage is provided in the first part. The main emphasis is placed on the usability point-of-view. On the basis of our analysis, we argue that the usability is the key issue enabling the wide adoption. The mobile gesture emergence was possible easily because the iPhone gestures were natural. Therefore, it was not necessary to learn them.The design and implementation of our presentation software, which is controlled by gestures, is outlined in the second part of the paper. Furthermore, the usability testing results are provided as well. We have tested our application on a group of users not instructed in the implemented gestures design. These results were compared with the other ones, obtained with our original implementation. The evaluation can be used as the basis for implementation of similar projects.

  1. Telephone-Based Coaching.

    Science.gov (United States)

    Boccio, Mindy; Sanna, Rashel S; Adams, Sara R; Goler, Nancy C; Brown, Susan D; Neugebauer, Romain S; Ferrara, Assiamira; Wiley, Deanne M; Bellamy, David J; Schmittdiel, Julie A

    2017-03-01

    Many Americans continue to smoke, increasing their risk of disease and premature death. Both telephone-based counseling and in-person tobacco cessation classes may improve access for smokers seeking convenient support to quit. Little research has assessed whether such programs are effective in real-world clinical populations. Retrospective cohort study comparing wellness coaching participants with two groups of controls. Kaiser Permanente Northern California, a large integrated health care delivery system. Two hundred forty-one patients who participated in telephonic tobacco cessation coaching from January 1, 2011, to March 31, 2012, and two control groups: propensity-score-matched controls, and controls who participated in a tobacco cessation class during the same period. Wellness coaching participants received an average of two motivational interviewing-based coaching sessions that engaged the patient, evoked their reason to consider quitting, and helped them establish a quit plan. Self-reported quitting of tobacco and fills of tobacco cessation medications within 12 months of follow-up. Logistic regressions adjusting for age, gender, race/ethnicity, and primary language. After adjusting for confounders, tobacco quit rates were higher among coaching participants vs. matched controls (31% vs. 23%, p Coaching participants and class attendees filled tobacco-cessation prescriptions at a higher rate (47% for both) than matched controls (6%, p coaching was as effective as in-person classes and was associated with higher rates of quitting compared to no treatment. The telephonic modality may increase convenience and scalability for health care systems looking to reduce tobacco use and improve health.

  2. Loyalty-based management.

    Science.gov (United States)

    Reichheld, F F

    1993-01-01

    Despite a flurry of activities aimed at serving customers better, few companies have systematically revamped their operations with customer loyalty in mind. Instead, most have adopted improvement programs ad hoc, and paybacks haven't materialized. Building a highly loyal customer base must be integral to a company's basic business strategy. Loyalty leaders like MBNA credit cards are successful because they have designed their entire business systems around customer loyalty--a self-reinforcing system in which the company delivers superior value consistently and reinvents cash flows to find and keep high-quality customers and employees. The economic benefits of high customer loyalty are measurable. When a company consistently delivers superior value and wins customer loyalty, market share and revenues go up, and the cost of acquiring new customers goes down. The better economics mean the company can pay workers better, which sets off a whole chain of events. Increased pay boosts employee moral and commitment; as employees stay longer, their productivity goes up and training costs fall; employees' overall job satisfaction, combined with their experience, helps them serve customers better; and customers are then more inclined to stay loyal to the company. Finally, as the best customers and employees become part of the loyalty-based system, competitors are left to survive with less desirable customers and less talented employees. To compete on loyalty, a company must understand the relationships between customer retention and the other parts of the business--and be able to quantify the linkages between loyalty and profits. It involves rethinking and aligning four important aspects of the business: customers, product/service offering, employees, and measurement systems.

  3. Base Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Everett Sondreal; John Hendrikson

    2009-03-31

    In June 2009, the Energy & Environmental Research Center (EERC) completed 11 years of research under the U.S. Department of Energy (DOE) Base Cooperative Agreement No. DE-FC26-98FT40320 funded through the Office of Fossil Energy (OFE) and administered at the National Energy Technology Laboratory (NETL). A wide range of diverse research activities were performed under annual program plans approved by NETL in seven major task areas: (1) resource characterization and waste management, (2) air quality assessment and control, (3) advanced power systems, (4) advanced fuel forms, (5) value-added coproducts, (6) advanced materials, and (7) strategic studies. This report summarizes results of the 67 research subtasks and an additional 50 strategic studies. Selected highlights in the executive summary illustrate the contribution of the research to the energy industry in areas not adequately addressed by the private sector alone. During the period of performance of the agreement, concerns have mounted over the impact of carbon emissions on climate change, and new programs have been initiated by DOE to ensure that fossil fuel resources along with renewable resources can continue to supply the nation's transportation fuel and electric power. The agreement has addressed DOE goals for reductions in CO{sub 2} emissions through efficiency, capture, and sequestration while expanding the supply and use of domestic energy resources for energy security. It has further contributed to goals for near-zero emissions from highly efficient coal-fired power plants; environmental control capabilities for SO{sub 2}, NO{sub x}, fine respirable particulate (PM{sub 2.5}), and mercury; alternative transportation fuels including liquid synfuels and hydrogen; and synergistic integration of fossil and renewable resources (e.g., wind-, biomass-, and coal-based electrical generation).

  4. Integrated Agent-based and Case-based Reasoning System

    International Nuclear Information System (INIS)

    Mohamed, A.H.

    2014-01-01

    Increasing the complexity of the modern systems drives to use multiple case bases in the case based reasoning (CBR) system to solve a single problem. Sometimes, it is difficult and unman gable task to store the knowledge of the domain of these complex systems in a single case base. On the other hand, usually these multiple case bases having different structures that cause main limitation for solving the problem. This research introduces integrating the case based systems using multiple case bases with agent-based technique. This enables the system to use different case base structures. The proposed system has been applied for designing the radiotherapy of the kidney, liver and skin cancers. It is found that, the suggested system has simplified, managed the complexity, increasing the accuracy of the of CBR systems. Therefore, it can be applied with a good performance for the practical sites

  5. A comparison between centre-based and expedition-based ...

    African Journals Online (AJOL)

    A comparison between centre-based and expedition-based (wilderness) adventure experiential learning regarding group effectiveness: A mixed methodology ... it is strongly recommended that a centre-based adventure program be used – mainly on account of active involvement, intensive social interaction and continuous ...

  6. NMR studies concerning base-base interactions in oligonucleotides

    International Nuclear Information System (INIS)

    Hoogen, Y.T. van den.

    1988-01-01

    Two main subjects are treated in the present thesis. The firsst part principally deals with the base-base interactions in single-stranded oligoribonucleotides. The second part presents NMR and model-building studies of DNA and RNA duplexes containing an unpaired base. (author). 242 refs.; 26 figs.; 24 tabs

  7. Implementation of Task-based and problem-based ...

    African Journals Online (AJOL)

    This paper describes implementation of new task-based and problem-based pharmacotherapy course for 3rd year pre-clinical medical students at Faculty of Medicine and Health Sciences, Omdurman Islamic University. Keywords: Pharmacotherapy, Task-based learning, P -drug. Sudan Journal of Medical Science Vol.

  8. Flow-Based Provenance

    Directory of Open Access Journals (Sweden)

    Sabah Al-Fedaghi

    2017-02-01

    Full Text Available Aim/Purpose: With information almost effortlessly created and spontaneously available, current progress in Information and Communication Technology (ICT has led to the complication that information must be scrutinized for trustworthiness and provenance. Information systems must become provenance-aware to be satisfactory in accountability, reproducibility, and trustworthiness of data. Background:\tMultiple models for abstract representation of provenance have been proposed to describe entities, people, and activities involved in producing a piece of data, including the Open Provenance Model (OPM and the World Wide Web Consortium. These models lack certain concepts necessary for specifying workflows and encoding the provenance of data products used and generated. Methodology: Without loss of generality, the focus of this paper is on OPM depiction of provenance in terms of a directed graph. We have redrawn several case studies in the framework of our proposed model in order to compare and evaluate it against OPM for representing these cases. Contribution: This paper offers an alternative flow-based diagrammatic language that can form a foundation for modeling of provenance. The model described here provides an (abstract machine-like representation of provenance. Findings: The results suggest a viable alternative in the area of diagrammatic representation for provenance applications. Future Research: Future work will seek to achieve more accurate comparisons with current models in the field.

  9. Refractory metal based superalloys

    International Nuclear Information System (INIS)

    Alonso, Paula R.; Vicente, Eduardo E.; Rubiolo, Gerardo H.

    1999-01-01

    Refractory metals are looked as promising materials for primary circuits in fission reactors and even as fusion reactor components. Indeed, superalloys could be developed which take advantage of their high temperature properties together with the benefits of a two- phase (intermetallic compound-refractory metal matrix) coherent structure. In 1993, researchers of the Office National d'Etudes et de Recherches Aerospatiales of France reported the observation of such a coherent structure in the Ta-Ti-Zr-Al-Nb-Mo system although the exact composition is not reported. The intermetallic compound would be Ti 2 AlMo based. However, the formation of this compound and its possible coexistence with a disordered bcc phase in the ternary system Ti-Al-Mo is a controversial subject in the related literature. In this work we develop a technique to obtain homogeneous alloys samples with 50 Ti-25 Al-25 Mo composition. The resulting specimens were characterized by optical and electronic metallography (SEM), microprobe composition measurements (EPMA) and X-ray diffraction (XRD) analyses. The results show the evidence for a bcc (A2→B2) ordering reaction in the Ti-Al-Mo system in the 50 Ti-25 Al-25 Mo composition. (author)

  10. Fluorescence lifetime based bioassays

    Science.gov (United States)

    Meyer-Almes, Franz-Josef

    2017-12-01

    Fluorescence lifetime (FLT) is a robust intrinsic property and material constant of fluorescent matter. Measuring this important physical indicator has evolved from a laboratory curiosity to a powerful and established technique for a variety of applications in drug discovery, medical diagnostics and basic biological research. This distinct trend was mainly driven by improved and meanwhile affordable laser and detection instrumentation on the one hand, and the development of suitable FLT probes and biological assays on the other. In this process two essential working approaches emerged. The first one is primarily focused on high throughput applications employing biochemical in vitro assays with no requirement for high spatial resolution. The second even more dynamic trend is the significant expansion of assay methods combining highly time and spatially resolved fluorescence data by fluorescence lifetime imaging. The latter approach is currently pursued to enable not only the investigation of immortal tumor cell lines, but also specific tissues or even organs in living animals. This review tries to give an actual overview about the current status of FLT based bioassays and the wide range of application opportunities in biomedical and life science areas. In addition, future trends of FLT technologies will be discussed.

  11. Mentalization-Based Treatment.

    Science.gov (United States)

    Bateman, Anthony; Fonagy, Peter

    2013-11-01

    The concept of mentalizing has captured the interest and imagination of an astonishing range of people-from psychoanalysts to neuroscientists, from child development researchers to geneticists, from existential philosophers to phenomenologists-all of whom seem to have found it useful. According to the Thompson Reuter maintained Web of Science, the use of the term in titles and abstracts of scientific papers increased from 10 to 2,750 between 1991 and 2011. Clinicians in particular have enthusiastically embraced the idea, and have put it to innovative use in their practices. Mentalization-based treatment (MBT)-making mentalizing a core focus of therapy-was initially developed for the treatment of borderline personality disorder (BPD) in routine clinical services delivered in group and individual modalities. Therapy with mentalizing as a central component is currently being developed for treatment of numerous groups, including people with antisocial personality disorder, substance abuse, eating disorders, and at-risk mothers with infants and children (A. Bateman & Fonagy, 2011). It is also being used with families and adolescents, in schools, and in managing social groups (Asen & Fonagy, 2011; Fonagy et al., 2009; Twemlow, Fonagy, & Sacco, 2005a, 2005b). In this article, we focus on MBT in the treatment of BPD.

  12. The Mayak Worker Dosimetry System (MWDS-2013): a comparison of intakes based on urine versus autopsy data from Mayak workers using the Leggett systemic model for plutonium

    International Nuclear Information System (INIS)

    Birchall, A.; Dorrian, M.-D.; Suslova, K. G.; Sokolova, A. B.

    2017-01-01

    The Mayak Worker Dosimetry System-2013 (MWDS-2013) uses a model developed by Leggett and colleagues to represent the biokinetic behaviour of plutonium after uptake to blood. Of particular importance, with regard to estimating intakes (and doses), is the distribution of activity between urine and body organs (particularly liver and skeleton). In this study, measurement data (urine and autopsy) from around 500 Mayak workers have been used to validate use of this model. A robust method has been developed and used to estimate intakes from both urine and autopsy data separately, and the ratio of these estimates has been calculated for each worker. The geometric mean ratio has been shown to lie within a range of 0.92-1.14, depending on assumptions made. Since this range includes 1, the hypothesis that the model is unbiased with regard to estimating intakes either with urine or autopsy data cannot be rejected on the basis of these data. This lends weight to the argument for increasing the MWDS-2013 cohort to include an additional 500 workers for whom only autopsy data are available, and who have previously been excluded from the cohort. Future directions in which this work could be extended are also suggested. (authors)

  13. Communication Base Station Log Analysis Based on Hierarchical Clustering

    Directory of Open Access Journals (Sweden)

    Zhang Shao-Hua

    2017-01-01

    Full Text Available Communication base stations generate massive data every day, these base station logs play an important value in mining of the business circles. This paper use data mining technology and hierarchical clustering algorithm to group the scope of business circle for the base station by recording the data of these base stations.Through analyzing the data of different business circle based on feature extraction and comparing different business circle category characteristics, which can choose a suitable area for operators of commercial marketing.

  14. Risk-based configuration control

    International Nuclear Information System (INIS)

    Szikszai, T.

    1997-01-01

    The presentation discusses the following issues: The Configuration Control; The Risk-based Configuration Control (during power operation mode, and during shutdown mode). PSA requirements. Use of Risk-based Configuration Control System. Configuration Management (basic elements, benefits, information requirements)

  15. Mindfulness-Based Stress Reduction

    Science.gov (United States)

    ... R S T U V W X Y Z Mindfulness-Based Stress Reduction (MBSR) Information 6 Things You ... Disease and Dementia (12/20/13) Research Spotlights Mindfulness-Based Stress Reduction, Cognitive-Behavioral Therapy Shown To ...

  16. ‘"Education-based Research"

    DEFF Research Database (Denmark)

    Degn Johansson, Troels

    This paper lays out a concept of education-based research-the production of research knowledge within the framework of tertiary design education-as an integration of problem-based learning and research-based education. This leads to a critique of reflective practice as the primary way to facilita...... learning at this level, a discussion of the nature of design problems in the instrumentalist tradition, and some suggestions as to how design studies curricula may facilitate education-based research....

  17. ASCOT data base management system

    Energy Technology Data Exchange (ETDEWEB)

    Barbieri, J.; Nyholm, R.; Castro, C.; Hill, K.

    1980-07-01

    The ASCOT data base management system is designed to handle the data produced by both the experimental and theoretical efforts of the DOE Atmospheric Studies in Complex Terrain (ASCOT) project. The data base envisioned is hierarchically structured, sparse, and compact. Information concerning any given data file is stored in a directory file. The data base management system uses a relational data management approach. Presently three management schema are being developed for use with the data base. 5 figures.

  18. Graphene based gene transfection

    Science.gov (United States)

    Feng, Liangzhu; Zhang, Shuai; Liu, Zhuang

    2011-03-01

    Graphene as a star in materials research has been attracting tremendous attentions in the past few years in various fields including biomedicine. In this work, for the first time we successfully use graphene as a non-toxic nano-vehicle for efficient gene transfection. Graphene oxide (GO) is bound with cationic polymers, polyethyleneimine (PEI) with two different molecular weights at 1.2 kDa and 10 kDa, forming GO-PEI-1.2k and GO-PEG-10k complexes, respectively, both of which are stable in physiological solutions. Cellular toxicity tests reveal that our GO-PEI-10k complex exhibits significantly reduced toxicity to the treated cells compared to the bare PEI-10k polymer. The positively charged GO-PEI complexes are able to further bind with plasmid DNA (pDNA) for intracellular transfection of the enhanced green fluorescence protein (EGFP) gene in HeLa cells. While EGFP transfection with PEI-1.2k appears to be ineffective, high EGFP expression is observed using the corresponding GO-PEI-1.2k as the transfection agent. On the other hand, GO-PEI-10k shows similar EGFP transfection efficiency but lower toxicity compared with PEI-10k. Our results suggest graphene to be a novel gene delivery nano-vector with low cytotoxicity and high transfection efficiency, promising for future applications in non-viral based gene therapy.Graphene as a star in materials research has been attracting tremendous attentions in the past few years in various fields including biomedicine. In this work, for the first time we successfully use graphene as a non-toxic nano-vehicle for efficient gene transfection. Graphene oxide (GO) is bound with cationic polymers, polyethyleneimine (PEI) with two different molecular weights at 1.2 kDa and 10 kDa, forming GO-PEI-1.2k and GO-PEG-10k complexes, respectively, both of which are stable in physiological solutions. Cellular toxicity tests reveal that our GO-PEI-10k complex exhibits significantly reduced toxicity to the treated cells compared to the bare PEI

  19. Home-based Healthcare Technology

    DEFF Research Database (Denmark)

    Verdezoto, Nervo

    of these systems target a specific treatment or condition and might not be sufficient to support the care management work at home. Based on a case study approach, my research investigates home-based healthcare practices and how they can inform future design of home-based healthcare technology that better account...

  20. Securing web-based exams

    NARCIS (Netherlands)

    Sessink, O.D.T.; Beeftink, H.H.; Tramper, J.; Hartog, R.J.M.

    2004-01-01

    Learning management systems may offer web-based exam facilities. Such facilities entail a higher risk to exams fraud than traditional paper-based exams. The article discusses security issues with web-based exams, and proposes precautionary measures to reduce the risks. A security model is presented

  1. Performance-Based Funding Brief

    Science.gov (United States)

    Washington Higher Education Coordinating Board, 2011

    2011-01-01

    A number of states have made progress in implementing performance-based funding (PFB) and accountability. This policy brief summarizes main features of performance-based funding systems in three states: Tennessee, Ohio, and Indiana. The brief also identifies key issues that states considering performance-based funding must address, as well as…

  2. Condition based spare parts supply

    NARCIS (Netherlands)

    Lin, X.; Basten, Robertus Johannes Ida; Kranenburg, A.A.; van Houtum, Geert-Jan

    2012-01-01

    We consider a spare parts stock point that serves an installed base of machines. Each machine contains the same critical component, whose degradation behavior is described by a Markov process. We consider condition based spare parts supply, and show that an optimal, condition based inventory policy

  3. Different perspectives on economic base.

    Science.gov (United States)

    Lisa K. Crone; Richard W. Haynes; Nicholas E. Reyna

    1999-01-01

    Two general approaches for measuring the economic base are discussed. Each method is used to define the economic base for each of the counties included in the Interior Columbia Basin Ecosystem Management Project area. A more detailed look at four selected counties results in similar findings from different approaches. Limitations of economic base analysis also are...

  4. Soy-based renoprotection

    Science.gov (United States)

    McGraw, Nancy J; Krul, Elaine S; Grunz-Borgmann, Elizabeth; Parrish, Alan R

    2016-01-01

    Chronic kidney disease (CKD) is a significant public health problem as risk factors such as advanced age, obesity, hypertension and diabetes rise in the global population. Currently there are no effective pharmacologic treatments for this disease. The role of diet is important for slowing the progression of CKD and managing symptoms in later stages of renal insufficiency. While low protein diets are generally recommended, maintaining adequate levels of intake is critical for health. There is an increasing appreciation that the source of protein may also be important. Soybean protein has been the most extensively studied plant-based protein in subjects with kidney disease and has demonstrated renal protective properties in a number of clinical studies. Soy protein consumption has been shown to slow the decline in estimated glomerular filtration rate and significantly improve proteinuria in diabetic and non-diabetic patients with nephropathy. Soy’s beneficial effects on renal function may also result from its impact on certain physiological risk factors for CKD such as dyslipidemia, hypertension and hyperglycemia. Soy intake is also associated with improvements in antioxidant status and systemic inflammation in early and late stage CKD patients. Studies conducted in animal models have helped to identify the underlying molecular mechanisms that may play a role in the positive effects of soy protein on renal parameters in polycystic kidney disease, metabolically-induced kidney dysfunction and age-associated progressive nephropathy. Despite the established relationship between soy and renoprotection, further studies are needed for a clear understanding of the role of the cellular and molecular target(s) of soy protein in maintaining renal function. PMID:27152261

  5. Telemetry-Based Ranging

    Science.gov (United States)

    Hamkins, Jon; Vilnrotter, Victor A.; Andrews, Kenneth S.; Shambayati, Shervin

    2011-01-01

    A telemetry-based ranging scheme was developed in which the downlink ranging signal is eliminated, and the range is computed directly from the downlink telemetry signal. This is the first Deep Space Network (DSN) ranging technology that does not require the spacecraft to transmit a separate ranging signal. By contrast, the evolutionary ranging techniques used over the years by NASA missions, including sequential ranging (transmission of a sequence of sinusoids) and PN-ranging (transmission of a pseudo-noise sequence) whether regenerative (spacecraft acquires, then regenerates and retransmits a noise-free ranging signal) or transparent (spacecraft feeds the noisy demodulated uplink ranging signal into the downlink phase modulator) relied on spacecraft power and bandwidth to transmit an explicit ranging signal. The state of the art in ranging is described in an emerging CCSDS (Consultative Committee for Space Data Systems) standard, in which a pseudo-noise (PN) sequence is transmitted from the ground to the spacecraft, acquired onboard, and the PN sequence is coherently retransmitted back to the ground, where a delay measurement is made between the uplink and downlink signals. In this work, the telemetry signal is aligned with the uplink PN code epoch. The ground station computes the delay between the uplink signal transmission and the received downlink telemetry. Such a computation is feasible because symbol synchronizability is already an integral part of the telemetry design. Under existing technology, the telemetry signal cannot be used for ranging because its arrival-time information is not coherent with any Earth reference signal. By introducing this coherence, and performing joint telemetry detection and arrival-time estimation on the ground, a high-rate telemetry signal can provide all the precision necessary for spacecraft ranging.

  6. Evidence-based dentistry.

    Science.gov (United States)

    Chambers, David W

    2010-01-01

    Both panegyric and criticism of evidence-based dentistry tend to be clumsy because the concept is poorly defined. This analysis identifies several contributions to the profession that have been made under the EBD banner. Although the concept of clinicians integrating clinical epidemiology, the wisdom of their practices, and patients' values is powerful, its implementation has been distorted by a too heavy emphasis of computerized searches for research findings that meet the standards of academics. Although EBD advocates enjoy sharing anecdotal accounts of mistakes others have made, faulting others is not proof that one's own position is correct. There is no systematic, high-quality evidence that EBD is effective. The metaphor of a three-legged stool (evidence, experience, values, and integration) is used as an organizing principle. "Best evidence" has become a preoccupation among EBD enthusiasts. That overlong but thinly developed leg of the stool is critiqued from the perspectives of the criteria for evidence, the difference between internal and external validity, the relationship between evidence and decision making, the ambiguous meaning of "best," and the role of reasonable doubt. The strongest leg of the stool is clinical experience. Although bias exists in all observations (including searches for evidence), there are simple procedures that can be employed in practice to increase useful and objective evidence there, and there are dangers in delegating policy regarding allowable treatments to external groups. Patient and practitioner values are the shortest leg of the stool. As they are so little recognized, their integration in EBD is problematic and ethical tensions exist where paternalism privileges science over patient's self-determined best interests. Four potential approaches to integration are suggested, recognizing that there is virtually no literature on how the "seat" of the three-legged stool works or should work. It is likely that most dentists

  7. Workplace Based Assessment in Psychiatry

    Directory of Open Access Journals (Sweden)

    Ayse Devrim Basterzi

    2009-11-01

    Full Text Available Workplace based assessment refers to the assessment of working practices based on what doctors actually do in the workplace, and is predominantly carried out in the workplace itself. Assessment drives learning and it is therefore essential that workplace-based assessment focuses on important attributes rather than what is easiest to assess. Workplacebased assessment is usually competency based. Workplace based assesments may well facilitate and enhance various aspects of educational supervisions, including its structure, frequency and duration etc. The structure and content of workplace based assesments should be monitored to ensure that its benefits are maximised by remaining tailored to individual trainees' needs. Workplace based assesment should be used for formative and summative assessments. Several formative assessment methods have been developed for use in the workplace such as mini clinical evaluation exercise (mini-cex, evidence based journal club assesment and case based discussion, multi source feedback etc. This review discusses the need of workplace based assesments in psychiatry graduate education and introduces some of the work place based assesment methods.

  8. Leveraging Evidence-Based Practice through Partnerships Based on Practice-Based Evidence

    Science.gov (United States)

    Cook, Bryan G.; Cook, Lysandra

    2016-01-01

    Evidence-based practice is among the most influential and compelling reforms in contemporary education. Despite their potential to improve the outcomes of students with disabilities, adoption and implementation of evidence-based reforms have been disappointing, with the gap between research and practice remaining wide. Practice-based evidence…

  9. Case-based reasoning: The marriage of knowledge base and data base

    Science.gov (United States)

    Pulaski, Kirt; Casadaban, Cyprian

    1988-01-01

    The coupling of data and knowledge has a synergistic effect when building an intelligent data base. The goal is to integrate the data and knowledge almost to the point of indistinguishability, permitting them to be used interchangeably. Examples given in this paper suggest that Case-Based Reasoning is a more integrated way to link data and knowledge than pure rule-based reasoning.

  10. Knowledge base verification based on enhanced colored petri net

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong Hyun; Seong, Poong Hyun [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    1997-12-31

    Verification is a process aimed at demonstrating whether a system meets it`s specified requirements. As expert systems are used in various applications, the knowledge base verification of systems takes an important position. The conventional Petri net approach that has been studied recently in order to verify the knowledge base is found that it is inadequate to verify the knowledge base of large and complex system, such as alarm processing system of nuclear power plant. Thus, we propose an improved method that models the knowledge base as enhanced colored Petri net. In this study, we analyze the reachability and the error characteristics of the knowledge base and apply the method to verification of simple knowledge base. 8 refs., 4 figs. (Author)

  11. XML-Based SHINE Knowledge Base Interchange Language

    Science.gov (United States)

    James, Mark; Mackey, Ryan; Tikidjian, Raffi

    2008-01-01

    The SHINE Knowledge Base Interchange Language software has been designed to more efficiently send new knowledge bases to spacecraft that have been embedded with the Spacecraft Health Inference Engine (SHINE) tool. The intention of the behavioral model is to capture most of the information generally associated with a spacecraft functional model, while specifically addressing the needs of execution within SHINE and Livingstone. As such, it has some constructs that are based on one or the other.

  12. Acids and bases solvent effects on acid-base strenght

    CERN Document Server

    Cox, Brian G

    2013-01-01

    Acids and bases are ubiquitous in chemistry. Our understanding of them, however, is dominated by their behaviour in water. Transfer to non-aqueous solvents leads to profound changes in acid-base strengths and to the rates and equilibria of many processes: for example, synthetic reactions involving acids, bases and nucleophiles; isolation of pharmaceutical actives through salt formation; formation of zwitter- ions in amino acids; and chromatographic separation of substrates. This book seeks to enhance our understanding of acids and bases by reviewing and analysing their behaviour in non-aqueous solvents. The behaviour is related where possible to that in water, but correlations and contrasts between solvents are also presented.

  13. Aperiodic-metamaterial-based absorber

    Directory of Open Access Journals (Sweden)

    Quanlong Yang

    2017-09-01

    Full Text Available The periodic-metamaterial-based perfect absorber has been studied broadly. Conversely, if the unit cell in the metamaterial-based absorber is arranged aperiodically (aperiodic-metamaterial-based absorber, how does it perform? Inspired by this, here we present a systematic study of the aperiodic-metamaterial-based absorber. By investigating the response of metamaterial absorbers based on periodic, Fibonacci, Thue-Morse, and quasicrystal lattices, we found that aperiodic-metamaterial-based absorbers could display similar absorption behaviors as the periodic one in one hand. However, their absorption behaviors show different tendency depending on the thicknesses of the spacer. Further studies on the angle and polarization dependence of the absorption behavior are also presented.

  14. Event-Based Conceptual Modeling

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    The paper demonstrates that a wide variety of event-based modeling approaches are based on special cases of the same general event concept, and that the general event concept can be used to unify the otherwise unrelated fields of information modeling and process modeling. A set of event-based mod......The paper demonstrates that a wide variety of event-based modeling approaches are based on special cases of the same general event concept, and that the general event concept can be used to unify the otherwise unrelated fields of information modeling and process modeling. A set of event......-based modeling approaches are analyzed and the results are used to formulate a general event concept that can be used for unifying the seemingly unrelated event concepts. Events are characterized as short-duration processes that have participants, consequences, and properties, and that may be modeled in terms...

  15. On Pimsner–Popa bases

    Indian Academy of Sciences (India)

    been mentioned for the Case of II1 factors in Lemma 4.3.4 (i) of [7] , but the proof there seems incomplete. Our characterization of bases now clarifies this point, and also shows that bases behave in a nice way with respect to the Jones' tower. As an application we show in §3.1 how the use of bases leads to a natural proof of.

  16. Principles of models based engineering

    Energy Technology Data Exchange (ETDEWEB)

    Dolin, R.M.; Hefele, J.

    1996-11-01

    This report describes a Models Based Engineering (MBE) philosophy and implementation strategy that has been developed at Los Alamos National Laboratory`s Center for Advanced Engineering Technology. A major theme in this discussion is that models based engineering is an information management technology enabling the development of information driven engineering. Unlike other information management technologies, models based engineering encompasses the breadth of engineering information, from design intent through product definition to consumer application.

  17. Estimating North Dakota's Economic Base

    OpenAIRE

    Coon, Randal C.; Leistritz, F. Larry

    2009-01-01

    North Dakota’s economic base is comprised of those activities producing a product paid for by nonresidents, or products exported from the state. North Dakota’s economic base activities include agriculture, mining, manufacturing, tourism, and federal government payments for construction and to individuals. Development of the North Dakota economic base data is important because it provides the information to quantify the state’s economic growth, and it creates the final demand sectors for the N...

  18. Image based Monument Recognition using Graph based Visual Saliency

    DEFF Research Database (Denmark)

    Kalliatakis, Grigorios; Triantafyllidis, Georgios

    2013-01-01

    This article presents an image-based application aiming at simple image classification of well-known monuments in the area of Heraklion, Crete, Greece. This classification takes place by utilizing Graph Based Visual Saliency (GBVS) and employing Scale Invariant Feature Transform (SIFT) or Speeded...

  19. Brain-Based Learning and Standards-Based Elementary Science.

    Science.gov (United States)

    Konecki, Loretta R.; Schiller, Ellen

    This paper explains how brain-based learning has become an area of interest to elementary school science teachers, focusing on the possible relationships between, and implications of, research on brain-based learning to the teaching of science education standards. After describing research on the brain, the paper looks at three implications from…

  20. Pyrone-based Cu (II) complexes, their characterization, DFT based ...

    Indian Academy of Sciences (India)

    Abstract. This work deals with the synthesis and characterization of a series of three -Dehydroacetic acid- 4-phenyl-3-thiosemicarbazide (H2dha-ptsc) Schiff base Cu(II) complexes based on combined experimental and theoretical approach, having the general composition formula as [Cu(dha-ptsc)(L-L)], where L-L is H2O, ...

  1. Managing the Gap between Curriculum Based and Problem Based Learning

    DEFF Research Database (Denmark)

    Bygholm, Ann; Buus, Lillian

    2009-01-01

    /or but rather both/and. In this paper we describe an approach to design and delivery of online courses in computer science which on the one hand is based on a specified curriculum and on the other hand gives room for different learning strategies, problem based learning being one of them. We discuss...

  2. Comparison of sequence-based and structure-based phylogenetic ...

    Indian Academy of Sciences (India)

    Prakash

    pairs of proteins which are inputs into the construction of phylogenetic trees. We find that correlation between the structure-based dissimilarity measures and the sequence-based dissimilarity measures is usually good if the sequence similarity among the homologues is about 30% or more. For protein families with low ...

  3. Capability-based computer systems

    CERN Document Server

    Levy, Henry M

    2014-01-01

    Capability-Based Computer Systems focuses on computer programs and their capabilities. The text first elaborates capability- and object-based system concepts, including capability-based systems, object-based approach, and summary. The book then describes early descriptor architectures and explains the Burroughs B5000, Rice University Computer, and Basic Language Machine. The text also focuses on early capability architectures. Dennis and Van Horn's Supervisor; CAL-TSS System; MIT PDP-1 Timesharing System; and Chicago Magic Number Machine are discussed. The book then describes Plessey System 25

  4. New Mexico Geothermal Data Base

    International Nuclear Information System (INIS)

    Witcher, J.C.; Whittier, J.; Morgan, R.

    1990-01-01

    This paper reports on the New Mexico Geothermal Data Base (NMGDB) which is a comprehensive public-domain data base of low-temperature geothermal resource information for New Mexico that is designed to assist researchers and developers. A broad range of geoscience, engineering, climatic, economic, and land status information are complied in the dBASE III PLUS data base management system for use on an IBM or IBM-compatible personal computer. A user friendly menu format with on-screen prompts allows easy and convenient use

  5. Fatigue data bases in Europe

    International Nuclear Information System (INIS)

    Olivier, R.; Koettgen, V.B.; Seeger, T.; Boller, C.

    1988-01-01

    Based on an inquiry with well-known European fatigue institutions the paper describes existing more or less extensive collections and data bases of S-N and crack growth data, mainly on unwelded and welded steel and aluminium in organizations and countries as follows: CEC, ESA, Federal Republic of Germany, GDR, Italy, Norway, Republic of Ireland, Switzerland, UK. This documentation of the present state is completed by a short survey on available European fatigue standards and design rules, serving as a data base for nominal materials data. Requirements for data base concepts, contents, user interface and data structure are presented in a short overview. (orig./HP)

  6. A Development of Domestic Food Chain Model Data for Chronic Effect Estimation of Off-site Consequence Analysis

    International Nuclear Information System (INIS)

    Han, Seok-Jung; KEUM, Dong-Kwon; Jang, Seung-Cheol

    2015-01-01

    The FCM includes complex transport phenomena of radiation materials on a biokinetic system of contaminated environments. An estimation of chronic health effects is a key part of the level 3 PSA (Probabilistic Safety Assessment), which depends on the FCM estimation from contaminated foods ingestion. A cultural ingestion habit of a local region and agricultural productions are different to the general features over worldwide scale or case by case. This is a reason to develop a domestic FCM data for the level 3 PSA. However, a generation of the specific FCM data is a complex process and under a large degree of uncertainty due to inherent biokinetic models. As a preliminary study, the present study focuses on an infrastructure development to generation of a specific FCM data. During this process, the features of FCM data to generate a domestic FCM data were investigated. Based on the insights obtained from this process, a specific domestic FCM data was developed. The present study was developed a domestic FCM data to estimate the chronic health effects of off-site consequence analysis. From this study, an insight was obtained, that a domestic FCM data is roughly 20 times higher than the MACCS2 defaults data. Based on this observation, it is clear that the specific chronic health effects of a domestic plant site should be considered in the off-site consequence analysis

  7. A Development of Domestic Food Chain Model Data for Chronic Effect Estimation of Off-site Consequence Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Han, Seok-Jung; KEUM, Dong-Kwon; Jang, Seung-Cheol [KAERI, Daejeon (Korea, Republic of)

    2015-05-15

    The FCM includes complex transport phenomena of radiation materials on a biokinetic system of contaminated environments. An estimation of chronic health effects is a key part of the level 3 PSA (Probabilistic Safety Assessment), which depends on the FCM estimation from contaminated foods ingestion. A cultural ingestion habit of a local region and agricultural productions are different to the general features over worldwide scale or case by case. This is a reason to develop a domestic FCM data for the level 3 PSA. However, a generation of the specific FCM data is a complex process and under a large degree of uncertainty due to inherent biokinetic models. As a preliminary study, the present study focuses on an infrastructure development to generation of a specific FCM data. During this process, the features of FCM data to generate a domestic FCM data were investigated. Based on the insights obtained from this process, a specific domestic FCM data was developed. The present study was developed a domestic FCM data to estimate the chronic health effects of off-site consequence analysis. From this study, an insight was obtained, that a domestic FCM data is roughly 20 times higher than the MACCS2 defaults data. Based on this observation, it is clear that the specific chronic health effects of a domestic plant site should be considered in the off-site consequence analysis.

  8. Methods in Logic Based Control

    DEFF Research Database (Denmark)

    Christensen, Georg Kronborg

    1999-01-01

    Desing and theory of Logic Based Control systems.Boolean Algebra, Karnaugh Map, Quine McClusky's algorithm. Sequential control design. Logic Based Control Method, Cascade Control Method. Implementation techniques: relay, pneumatic, TTL/CMOS,PAL and PLC- and Soft_PLC implementation. PLC...

  9. Component Based Testing with ioco

    NARCIS (Netherlands)

    van der Bijl, H.M.; Rensink, Arend; Tretmans, G.J.

    Component based testing concerns the integration of components which have already been tested separately. We show that, with certain restrictions, the ioco-test theory for conformance testing is suitable for component based testing, in the sense that the integration of fully conformant components is

  10. Theory-Based Stakeholder Evaluation

    Science.gov (United States)

    Hansen, Morten Balle; Vedung, Evert

    2010-01-01

    This article introduces a new approach to program theory evaluation called theory-based stakeholder evaluation or the TSE model for short. Most theory-based approaches are program theory driven and some are stakeholder oriented as well. Practically, all of the latter fuse the program perceptions of the various stakeholder groups into one unitary…

  11. Forest biomass-based energy

    Science.gov (United States)

    Janaki R. R. Alavalapati; Pankaj Lal; Andres Susaeta; Robert C. Abt; David N. Wear

    2013-01-01

    Key FindingsHarvesting woody biomass for use as bioenergy is projected to range from 170 million to 336 million green tons by 2050, an increase of 54 to 113 percent over current levels.Consumption projections for forest biomass-based energy, which are based on Energy Information Administration projections, have a high level of...

  12. Defining Nature-Based Preschools

    Science.gov (United States)

    Larimore, Rachel

    2016-01-01

    Nature-based early childhood education. Nature-based preschool. Nature preschool. Forest kindergarten. Nature kindergarten. Waldkindergarten. Forest school. These are a few of the program terms currently being discussed among early childhood environmental education professionals in the United States. Why is there so much discussion about the names…

  13. Cloud-Based Data Storage

    Science.gov (United States)

    Waters, John K.

    2011-01-01

    The vulnerability and inefficiency of backing up data on-site is prompting school districts to switch to more secure, less troublesome cloud-based options. District auditors are pushing for a better way to back up their data than the on-site, tape-based system that had been used for years. About three years ago, Hendrick School District in…

  14. Plasma-based accelerator structures

    International Nuclear Information System (INIS)

    Schroeder, Carl B.

    1999-01-01

    Plasma-based accelerators have the ability to sustain extremely large accelerating gradients, with possible high-energy physics applications. This dissertation further develops the theory of plasma-based accelerators by addressing three topics: the performance of a hollow plasma channel as an accelerating structure, the generation of ultrashort electron bunches, and the propagation of laser pulses is underdense plasmas

  15. Dimensions of problem based learning

    DEFF Research Database (Denmark)

    Nielsen, Jørgen Lerche; Andreasen, Lars Birch

    2013-01-01

    The article contributes to the literature on problem based learning and problem-oriented project work, building on and reflecting the experiences of the authors through decades of work with problem-oriented project pedagogy. The article explores different dimensions of problem based learning such...

  16. Dog Mathematics: Exploring Base-4

    Science.gov (United States)

    Kurz, Terri L.; Yanik, H. Bahadir; Lee, Mi Yeon

    2016-01-01

    Using a dog's paw as a basis for numerical representation, sixth grade students explored how to count and regroup using the dog's four digital pads. Teachers can connect these base-4 explorations to the conceptual meaning of place value and regrouping using base-10.

  17. Evidence-based playground design

    DEFF Research Database (Denmark)

    Refshauge, Anne Dahl; Stigsdotter, Ulrika K.; Lamm, Bettina

    2015-01-01

    opportunities for play, nature exploration and sensory stimulation. As it is increasingly expected that designers base their decisions on research evidence, there is a need to develop approaches to facilitate this, which also applies to playground design. The design of PlayLab Cph was based on relevant evidence...

  18. Power Reactor Embrittlement Data Base

    International Nuclear Information System (INIS)

    Kam, F.B.K.; Stallmann, F.W.; Wang, J.A.

    1990-01-01

    Regulatory and research evaluations of embrittlement predication models and of pressure vessel integrity can be greatly expedited by the use of a well-designed, computerized data base. The Power Reactor Embrittlement Data Base (PR-EDB) is such a comprehensive collection of data for US commercial nuclear reactors. The Nuclear Regulatory Commission (NRC) has provided financial support, and the Electric Power Research Institute (EPRI) has provided technical assistance in the quality assurance (QA) of the data to establish an industry-wide data base that will be maintained and updated on a long-term basis. Successful applications of the data base to several of NRC's evaluations have received favorable response and support for its continuation. The future direction of the data base has been designed to include the test reactor and other types of data of interest to the regulators and the researchers. 1 ref

  19. The knowledge base of journalism

    DEFF Research Database (Denmark)

    Svith, Flemming

    In this paper I propose the knowledge base as a fruitful way to apprehend journalism. With the claim that the majority of practice is anchored in knowledge – understood as 9 categories of rationales, forms and levels – this knowledge base appears as a contextual look at journalists’ knowledge....... It is an analytical framework to delineate what is special in journalists’ knowledge. While the base is referred to in singular, it makes good sense to talk about journalistic knowledge in plural, because of the variation in the categories’ specific content and significance. This depends on the field position, time......, and place. As an analytical framework, the knowledge base is limited to understand the practice of newspaper journalists, but, conversely, the knowledge base encompasses more general beginnings through the inclusion of overall structural relationships in the media and journalism and general theories...

  20. Content-Based Image Retrial Based on Hadoop

    Directory of Open Access Journals (Sweden)

    DongSheng Yin

    2013-01-01

    Full Text Available Generally, time complexity of algorithms for content-based image retrial is extremely high. In order to retrieve images on large-scale databases efficiently, a new way for retrieving based on Hadoop distributed framework is proposed. Firstly, a database of images features is built by using Speeded Up Robust Features algorithm and Locality-Sensitive Hashing and then perform the search on Hadoop platform in a parallel way specially designed. Considerable experimental results show that it is able to retrieve images based on content on large-scale cluster and image sets effectively.

  1. Value-based metrics and Internet-based enterprises

    Science.gov (United States)

    Gupta, Krishan M.

    2001-10-01

    Within the last few years, a host of value-based metrics like EVA, MVA, TBR, CFORI, and TSR have evolved. This paper attempts to analyze the validity and applicability of EVA and Balanced Scorecard for Internet based organizations. Despite the collapse of the dot-com model, the firms engaged in e- commerce continue to struggle to find new ways to account for customer-base, technology, employees, knowledge, etc, as part of the value of the firm. While some metrics, like the Balance Scorecard are geared towards internal use, others like EVA are for external use. Value-based metrics are used for performing internal audits as well as comparing firms against one another; and can also be effectively utilized by individuals outside the firm looking to determine if the firm is creating value for its stakeholders.

  2. Object-based media and stream-based computing

    Science.gov (United States)

    Bove, V. Michael, Jr.

    1998-03-01

    Object-based media refers to the representation of audiovisual information as a collection of objects - the result of scene-analysis algorithms - and a script describing how they are to be rendered for display. Such multimedia presentations can adapt to viewing circumstances as well as to viewer preferences and behavior, and can provide a richer link between content creator and consumer. With faster networks and processors, such ideas become applicable to live interpersonal communications as well, creating a more natural and productive alternative to traditional videoconferencing. In this paper is outlined an example of object-based media algorithms and applications developed by my group, and present new hardware architectures and software methods that we have developed to enable meeting the computational requirements of object- based and other advanced media representations. In particular we describe stream-based processing, which enables automatic run-time parallelization of multidimensional signal processing tasks even given heterogenous computational resources.

  3. SB certification for mixture-based specification for flexible base.

    Science.gov (United States)

    2012-10-01

    Presentation topics: : Establish List of Qualified Producers; : Producers Responsible for Process Control/Quality Control; : Reduce TxDOT Sampling and Testing; : Expedite Aggregate Base Acceptance; : Share Responsibility (Producer/TxDOT) for Quality ...

  4. Designing Android Based Augmented Reality Location-Based Service Application

    Directory of Open Access Journals (Sweden)

    Alim Hardiansyah

    2018-01-01

    Full Text Available Android is an operating system for Linux based smartphone. Android provides an open platform for the developers to create their own application. The most developed and used application now is location based application. This application gives personalization service for mobile device user and is customized to their location. Location based service also gives an opportunity for the developers to develop and increase the value of service. One of the technologies that could be combined with location based application is augmented reality. Augmented reality combines the virtual world with the real one. By the assistance of augmented reality, our surrounding environment could interact in digital form. Information of objects and environment surround us could be added to the augmented reality system and presented. Based on the background, the writers tried to implement those technologies on now rapidly developing android application as a final project to achieve bachelor degree in Department of Informatics Engineering, Faculty of Information Technology and Visual Communication, Al Kamal Science and Technology Institute. This application could be functioned to locate school by using location based service technology with the assistance of navigational applications such as waze and google maps, in form of live direction process through the smartphone

  5. WPS criterion proposition based on experimental data base interpretation

    International Nuclear Information System (INIS)

    Chapuliot, S.; Izard, J.P.; Moinereau, D.; Marie, S.

    2011-01-01

    This article gives the background and the methodology developed to define a K J based criterion for brittle fracture of Reactor Pressure Vessel (RPV) submitted to Pressurized Thermal Shock (PTS), and taking into account Warm Pre Stressing effect (WPS). The first step of this methodology is the constitution of an experimental data base. This work was performed through bibliography and partnerships, and allows merging experimental results dealing with: -) Various ferritic steels; -) Various material states (as received, thermally aged, irradiated...); -) Various mode of fracture (cleavage, inter-granular, mixed mode); -) Various specimen geometry and size (CT, SENB, mock-ups); -) Various thermo-mechanical transients. Based on this experimental data base, a simple K J based limit is proposed and compared to experimental results. Parametric studies are performed in order to define the main parameters of the problem. Finally, a simple proposition based on a detailed analysis of tests results is performed. This proposition giving satisfactory results in every cases, it constitutes a good candidate for integration in French RSE-M code for in service assessment. (authors)

  6. Home-based versus centre-based cardiac rehabilitation.

    Science.gov (United States)

    Anderson, Lindsey; Sharp, Georgina A; Norton, Rebecca J; Dalal, Hasnain; Dean, Sarah G; Jolly, Kate; Cowie, Aynsley; Zawada, Anna; Taylor, Rod S

    2017-06-30

    Cardiovascular disease is the most common cause of death globally. Traditionally, centre-based cardiac rehabilitation programmes are offered to individuals after cardiac events to aid recovery and prevent further cardiac illness. Home-based cardiac rehabilitation programmes have been introduced in an attempt to widen access and participation. This is an update of a review previously published in 2009 and 2015. To compare the effect of home-based and supervised centre-based cardiac rehabilitation on mortality and morbidity, exercise-capacity, health-related quality of life, and modifiable cardiac risk factors in patients with heart disease. We updated searches from the previous Cochrane Review by searching the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (Ovid), Embase (Ovid), PsycINFO (Ovid) and CINAHL (EBSCO) on 21 September 2016. We also searched two clinical trials registers as well as previous systematic reviews and reference lists of included studies. No language restrictions were applied. We included randomised controlled trials, including parallel group, cross-over or quasi-randomised designs) that compared centre-based cardiac rehabilitation (e.g. hospital, gymnasium, sports centre) with home-based programmes in adults with myocardial infarction, angina, heart failure or who had undergone revascularisation. Two review authors independently screened all identified references for inclusion based on pre-defined inclusion criteria. Disagreements were resolved through discussion or by involving a third review author. Two authors independently extracted outcome data and study characteristics and assessed risk of bias. Quality of evidence was assessed using GRADE principles and a Summary of findings table was created. We included six new studies (624 participants) for this update, which now includes a total of 23 trials that randomised a total of 2890 participants undergoing cardiac rehabilitation. Participants had an acute myocardial

  7. Eye-based head gestures

    DEFF Research Database (Denmark)

    Mardanbegi, Diako; Witzner Hansen, Dan; Pederson, Thomas

    2012-01-01

    A novel method for video-based head gesture recognition using eye information by an eye tracker has been proposed. The method uses a combination of gaze and eye movement to infer head gestures. Compared to other gesture-based methods a major advantage of the method is that the user keeps the gaze...... on the interaction object while interacting. This method has been implemented on a head-mounted eye tracker for detecting a set of predefined head gestures. The accuracy of the gesture classifier is evaluated and verified for gaze-based interaction in applications intended for both large public displays and small...

  8. Solar based hydrogen production systems

    CERN Document Server

    Dincer, Ibrahim

    2013-01-01

    This book provides a comprehensive analysis of various solar based hydrogen production systems. The book covers first-law (energy based) and second-law (exergy based) efficiencies and provides a comprehensive understanding of their implications. It will help minimize the widespread misuse of efficiencies among students and researchers in energy field by using an intuitive and unified approach for defining efficiencies. The book gives a clear understanding of the sustainability and environmental impact analysis of the above systems. The book will be particularly useful for a clear understanding

  9. Wavelength conversion based spectral imaging

    DEFF Research Database (Denmark)

    Dam, Jeppe Seidelin

    There has been a strong, application driven development of Si-based cameras and spectrometers for imaging and spectral analysis of light in the visible and near infrared spectral range. This has resulted in very efficient devices, with high quantum efficiency, good signal to noise ratio and high...... resolution for this spectral region. Today, an increasing number of applications exists outside the spectral region covered by Si-based devices, e.g. within cleantech, medical or food imaging. We present a technology based on wavelength conversion which will extend the spectral coverage of state of the art...... visible or near infrared cameras and spectrometers to include other spectral regions of interest....

  10. Reconsidering Community-based Retailing

    OpenAIRE

    Maughan, Rebecca; O'Driscoll, Aidan

    2012-01-01

    One of the areas with great potential for economic, social and environmental benefit is community-based retailing. The concept of community based retailing can incorporate a number of different tenets. We suggest that it is retailing that is based close to the community it serves, usually within the town or village centre rather than out-of-town locations, and which is composed of a diverse range of small and medium sized business that are often independently or co-operatively owned. These co...

  11. Mitochondrial base excision repair assays

    DEFF Research Database (Denmark)

    Maynard, Scott; de Souza-Pinto, Nadja C; Scheibye-Knudsen, Morten

    2010-01-01

    The main source of mitochondrial DNA (mtDNA) damage is reactive oxygen species (ROS) generated during normal cellular metabolism. The main mtDNA lesions generated by ROS are base modifications, such as the ubiquitous 8-oxoguanine (8-oxoG) lesion; however, base loss and strand breaks may also occur....... Many human diseases are associated with mtDNA mutations and thus maintaining mtDNA integrity is critical. All of these lesions are repaired primarily by the base excision repair (BER) pathway. It is now known that mammalian mitochondria have BER, which, similarly to nuclear BER, is catalyzed by DNA...

  12. Assessment of Dose to the Nursing Infant from Radionuclides in Breast Milk

    Energy Technology Data Exchange (ETDEWEB)

    Leggett, Richard Wayne [ORNL; Eckerman, Keith F [ORNL

    2010-03-01

    A computer software package was developed to predict tissue doses to an infant due to intake of radionuclides in breast milk based on bioassay measurements and exposure data for the mother. The package is intended mainly to aid in decisions regarding the safety of breast feeding by a mother who has been acutely exposed to a radionuclide during lactation or pregnancy, but it may be applied to previous intakes during the mother s adult life. The package includes biokinetic and dosimetric information needed to address intake of Co-60, Sr-90, Cs-134, Cs-137, Ir-192, Pu-238, Pu-239, Am-241, or Cf-252 by the mother. It has been designed so that the library of biokinetic and dosimetric files can be expanded to address a more comprehensive set of radionuclides without modifying the basic computational module. The methods and models build on the approach used in Publication 95 of the International Commission on Radiological Protection (ICRP 2004), Doses to Infants from Ingestion of Radionuclides in Mothers Milk . The software package allows input of case-specific information or judgments such as chemical form or particle size of an inhaled aerosol. The package is expected to be more suitable than ICRP Publication 95 for dose assessment for real events or realistic planning scenarios in which measurements of the mother s excretion or body burden are available.

  13. Compartmental analysis and dosimetric aspects applied to cholesterol with {sup 3}H labeled; Analise compartimental e aspectos dosimetricos aplicados ao colesterol marcado com {sup 3}H

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Adriano dos Santos

    2015-07-01

    Cardiovascular diseases (CVDs) are one of the major reasons of death around the world according to the World Health Organization (WHO). It is well known that changes in levels of plasma lipoproteins, which are responsible for the transport of cholesterol into the bloodstream, are associated with cardiovascular diseases. For this reason to know the biokinetic parameters of plasma lipoproteins and quantifies them is important to correct and deep understanding about the diseases associated with these disorders. The main aim of this study is to provide a biokinetic model and estimate the radiometric doses for {sup 3}H-Cholesterol, a radioactive tracer widely used in physiological and metabolic studies. The model was based on [Schwartz et al. 2004] about the distribution of cholesterol by the lipoprotein and gastrointestinal model [ICRP 30, 1979]. The doses distribution in compartments of the model and other organs and tissues of a standard adult described in [ICRP 106, 2008] was calculated using MIRD method (Medical Internal Radiation Dose) and compartmental analysis using the computer program Matlab®. The dose coefficients were estimated for a standard phantom man (73 kg) described in [ICRP 60, 1991]. The estimated doses for both model and for other organs were low and did not exceed the highest dose obtained that was in the upper large intestine, as 44,8 μGy these parameters will assist in ethics committee's opinions on the use of works that use the {sup 3}H-cholesterol which radioactive tracer. (author)

  14. Compartmental analysis and dosimetric aspects applied to cholesterol with 3H labeled

    International Nuclear Information System (INIS)

    Oliveira, Adriano dos Santos

    2015-01-01

    Cardiovascular diseases (CVDs) are one of the major reasons of death around the world according to the World Health Organization (WHO). It is well known that changes in levels of plasma lipoproteins, which are responsible for the transport of cholesterol into the bloodstream, are associated with cardiovascular diseases. For this reason to know the biokinetic parameters of plasma lipoproteins and quantifies them is important to correct and deep understanding about the diseases associated with these disorders. The main aim of this study is to provide a biokinetic model and estimate the radiometric doses for 3 H-Cholesterol, a radioactive tracer widely used in physiological and metabolic studies. The model was based on [Schwartz et al. 2004] about the distribution of cholesterol by the lipoprotein and gastrointestinal model [ICRP 30, 1979]. The doses distribution in compartments of the model and other organs and tissues of a standard adult described in [ICRP 106, 2008] was calculated using MIRD method (Medical Internal Radiation Dose) and compartmental analysis using the computer program Matlab®. The dose coefficients were estimated for a standard phantom man (73 kg) described in [ICRP 60, 1991]. The estimated doses for both model and for other organs were low and did not exceed the highest dose obtained that was in the upper large intestine, as 44,8 μGy these parameters will assist in ethics committee's opinions on the use of works that use the 3 H-cholesterol which radioactive tracer. (author)

  15. Animal study on biological responses by radon inhalation making use of waste rock which contains feeble activity of uranium (2) (Joint research)

    International Nuclear Information System (INIS)

    Ishimori, Yuu; Sakoda, Akihiro; Tanaka, Hiroshi; Mitsunobu, Fumihiro; Yamaoka, Kiyonori; Kataoka, Takahiro; Etani, Reo

    2016-03-01

    Okayama University and the Japan Atomic Energy Agency (JAEA) have carried out the collaborative study of physiological effects of inhaled radon for the low-dose range. Main assignments were as follows. Based on the clinical knowledge, Misasa Medical Center (Okayama University Hospital) clarified the issues that should be addressed. Graduate School of Health Sciences (Okayama University) supervised the research and studied the biological responses. The JAEA made the development and control of a facility for radon inhalation experiments and the investigation of biokinetics and exposure doses of radon. From 2009 to 2013, the following results were obtained. (1) Literature on drinking effects of radon hot spring water was surveyed to determine the present tasks. (2) Under the present experimental conditions, drinking of hot spring water into which radon was intentionally introduced using the equipment in the facility did not have significant effects on mice. (3) Inhibitory effects of antioxidant pre-supplements (Vitamins C and E) and radon pre-inhalation on hepatic or renal oxidative damage were examined to make the comparison. (4) In order to discuss biological responses quantitatively following radon inhalation, the biokinetics of inhaled radon were studied. (5) Some exposure routes due to inhalation of radon or its progeny were modeled to calculate organ doses in mice. (author)

  16. Animal study on biological responses by radon inhalation making use of waste rock which contains feeble activity of uranium (Joint research)

    International Nuclear Information System (INIS)

    Ishimori, Yuu; Sakoda, Akihiro; Tanaka, Hiroshi; Mitsunobu, Fumihiro; Yamaoka, Kiyonori; Kataoka, Takahiro; Yamato, Keiko; Nishiyama, Yuichi

    2013-06-01

    Okayama University and the Japan Atomic Energy Agency (JAEA) have carried out the collaborative study of physiological effects of inhaled radon for the low-dose range. Main assignments were as follows. Based on the clinical knowledge, Misasa Medical Center (Okayama University Hospital) clarified the issues that should be addressed. Graduate School of Health Sciences (Okayama University) supervised the research and studied the biological responses. The JAEA made the development and control of a facility for radon inhalation experiments and the investigation of biokinetics and absorbed doses of radon. From 2007 to 2011, the following results were obtained. (1) Literature on effects of radon for the low-dose range was surveyed to determine the present tasks. (2) The first Japanese large-scale facility was developed for radon inhalation experiments with small animals. (3) Relationships between radon concentration and inhalation time were widely examined to understand the change in antioxidative functions due to radon, which are the most basic parameters. (4) Inhibitory effects of radon on oxidative damages were observed using model mice with reactive oxygen- or free radical-related diseases like alcohol-induced oxidative damages and type I diabetes. (5) In order to discuss biological responses quantitatively following radon inhalation, the biokinetics of inhaled radon was examined and the model for calculation of absorbed doses for organs and tissues was obtained. (author)

  17. Measuring Rates of Herbicide Metabolism in Dicot Weeds with an Excised Leaf Assay.

    Science.gov (United States)

    Ma, Rong; Skelton, Joshua J; Riechers, Dean E

    2015-09-07

    In order to isolate and accurately determine rates of herbicide metabolism in an obligate-outcrossing dicot weed, waterhemp (Amaranthus tuberculatus), we developed an excised leaf assay combined with a vegetative cloning strategy to normalize herbicide uptake and remove translocation as contributing factors in herbicide-resistant (R) and -sensitive (S) waterhemp populations. Biokinetic analyses of organic pesticides in plants typically include the determination of uptake, translocation (delivery to the target site), metabolic fate, and interactions with the target site. Herbicide metabolism is an important parameter to measure in herbicide-resistant weeds and herbicide-tolerant crops, and is typically accomplished with whole-plant tests using radiolabeled herbicides. However, one difficulty with interpreting biokinetic parameters derived from whole-plant methods is that translocation is often affected by rates of herbicide metabolism, since polar metabolites are usually not mobile within the plant following herbicide detoxification reactions. Advantages of the protocol described in this manuscript include reproducible, accurate, and rapid determination of herbicide degradation rates in R and S populations, a substantial decrease in the amount of radiolabeled herbicide consumed, a large reduction in radiolabeled plant materials requiring further handling and disposal, and the ability to perform radiolabeled herbicide experiments in the lab or growth chamber instead of a greenhouse. As herbicide resistance continues to develop and spread in dicot weed populations worldwide, the excised leaf assay method developed and described herein will provide an invaluable technique for investigating non-target site-based resistance due to enhanced rates of herbicide metabolism and detoxification.

  18. Uncertainties in Cancer Risk Coefficients for Environmental Exposure to Radionuclides. An Uncertainty Analysis for Risk Coefficients Reported in Federal Guidance Report No. 13

    Energy Technology Data Exchange (ETDEWEB)

    Pawel, David [U.S. Environmental Protection Agency; Leggett, Richard Wayne [ORNL; Eckerman, Keith F [ORNL; Nelson, Christopher [U.S. Environmental Protection Agency

    2007-01-01

    Federal Guidance Report No. 13 (FGR 13) provides risk coefficients for estimation of the risk of cancer due to low-level exposure to each of more than 800 radionuclides. Uncertainties in risk coefficients were quantified in FGR 13 for 33 cases (exposure to each of 11 radionuclides by each of three exposure pathways) on the basis of sensitivity analyses in which various combinations of plausible biokinetic, dosimetric, and radiation risk models were used to generate alternative risk coefficients. The present report updates the uncertainty analysis in FGR 13 for the cases of inhalation and ingestion of radionuclides and expands the analysis to all radionuclides addressed in that report. The analysis indicates that most risk coefficients for inhalation or ingestion of radionuclides are determined within a factor of 5 or less by current information. That is, application of alternate plausible biokinetic and dosimetric models and radiation risk models (based on the linear, no-threshold hypothesis with an adjustment for the dose and dose rate effectiveness factor) is unlikely to change these coefficients by more than a factor of 5. In this analysis the assessed uncertainty in the radiation risk model was found to be the main determinant of the uncertainty category for most risk coefficients, but conclusions concerning the relative contributions of risk and dose models to the total uncertainty in a risk coefficient may depend strongly on the method of assessing uncertainties in the risk model.

  19. Oil-based paint poisoning

    Science.gov (United States)

    Paint - oil-based - poisoning ... Hydrocarbons are the primary poisonous ingredient in oil paints. Some oil paints have heavy metals such as lead, mercury, cobalt, and barium added as pigment. These heavy metals can cause additional ...

  20. Imprinted silicon-based nanophotonics

    DEFF Research Database (Denmark)

    Borel, Peter Ingo; Olsen, Brian Bilenberg; Frandsen, Lars Hagedorn

    2007-01-01

    We demonstrate and optically characterize silicon-on-insulator based nanophotonic devices fabricated by nanoimprint lithography. In our demonstration, we have realized ordinary and topology-optimized photonic crystal waveguide structures. The topology-optimized structures require lateral pattern...

  1. Querying Natural Logic Knowledge Bases

    DEFF Research Database (Denmark)

    Andreasen, Troels; Bulskov, Henrik; Jensen, Per Anker

    2017-01-01

    This paper describes the principles of a system applying natural logic as a knowledge base language. Natural logics are regimented fragments of natural language employing high level inference rules. We advocate the use of natural logic for knowledge bases dealing with querying of classes in ontol......This paper describes the principles of a system applying natural logic as a knowledge base language. Natural logics are regimented fragments of natural language employing high level inference rules. We advocate the use of natural logic for knowledge bases dealing with querying of classes...... in ontologies and class-relationships such as are common in life-science descriptions. The paper adopts a version of natural logic with recursive restrictive clauses such as relative clauses and adnominal prepositional phrases. It includes passive as well as active voice sentences. We outline a prototype...

  2. SAT-Based Software Certification

    National Research Council Canada - National Science Library

    Chaki, Sagar

    2006-01-01

    ... predicate abstraction and validated by generating and proving verification conditions. In addition, the first part of the report proposes the use of theorem provers based on Boolean propositional satisfiability (SAT...

  3. Chip-based droplet sorting

    Energy Technology Data Exchange (ETDEWEB)

    Beer, Neil Reginald; Lee, Abraham; Hatch, Andrew

    2017-11-21

    A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting.

  4. Chip-based droplet sorting

    Science.gov (United States)

    Beer, Neil Reginald; Lee, Abraham; Hatch, Andrew

    2014-07-01

    A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting.

  5. Graph Model Based Indoor Tracking

    DEFF Research Database (Denmark)

    Jensen, Christian Søndergaard; Lu, Hua; Yang, Bin

    2009-01-01

    The tracking of the locations of moving objects in large indoor spaces is important, as it enables a range of applications related to, e.g., security and indoor navigation and guidance. This paper presents a graph model based approach to indoor tracking that offers a uniform data management...... infrastructure for different symbolic positioning technologies, e.g., Bluetooth and RFID. More specifically, the paper proposes a model of indoor space that comprises a base graph and mappings that represent the topology of indoor space at different levels. The resulting model can be used for one or several...... indoor positioning technologies. Focusing on RFID-based positioning, an RFID specific reader deployment graph model is built from the base graph model. This model is then used in several algorithms for constructing and refining trajectories from raw RFID readings. Empirical studies with implementations...

  6. Base Flood Elevation (BFE) Lines

    Data.gov (United States)

    Department of Homeland Security — The Base Flood Elevation (BFE) table is required for any digital data where BFE lines will be shown on the corresponding Flood Insurance Rate Map (FIRM). Normally if...

  7. Hospital Value-Based Purchasing

    Data.gov (United States)

    U.S. Department of Health & Human Services — Hospital Value-Based Purchasing (VBP) is part of the Centers for Medicare and Medicaid Services (CMS) long-standing effort to link Medicares payment system to a...

  8. Random Decrement Based FRF Estimation

    DEFF Research Database (Denmark)

    Brincker, Rune; Asmussen, J. C.

    The problem of estimating frequency response functions and extracting modal parameters is the topic of this paper. A new method based on the Random Decrement technique combined with Fourier transformation and the traditional pure Fourier transformation based approach is compared with regard...... to speed and quality. The basis of the new method is the Fourier transformation of the Random Decrement functions which can be used to estimate the frequency response functions. The investigations are based on load and response measurements of a laboratory model of a 3 span bridge. By applying both methods...... to these measurements the estimation time of the frequency response functions can be compared. The modal parameters estimated by the methods are compared. It is expected that the Random Decrement technique is faster than the traditional method based on pure Fourier Transformations. This is due to the fact...

  9. Industry Based Survey (IBS) Yellowtail

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The "Southern New England Yellowtail Flounder Industry-Based Survey" was a collaboration between the Rhode Island Division of Fish and Wildlife and the fishing...

  10. PHYSIOLOGY OF ACID BASE BALANCE

    Directory of Open Access Journals (Sweden)

    Awati

    2014-12-01

    Full Text Available Acid-base, electrolyte, and metabolic disturbances are common in the intensive care unit. Almost all critically ill patients often suffer from compound acid-base and electrolyte disorders. Successful evaluation and management of such patients requires recognition of common patterns (e.g., metabolic acidosis and the ability to dissect one disorder from another. The intensivists needs to identify and correct these condition with the easiest available tools as they are the associated with multiorgan failure. Understanding the elements of normal physiology in these areas is very important so as to diagnose the pathological condition and take adequate measures as early as possible. Arterial blood gas analysis is one such tool for early detection of acid base disorder. Physiology of acid base is complex and here is the attempt to simplify it in our day to day application for the benefit of critically ill patients.

  11. NORTHWOODS Wildlife Habitat Data Base

    Science.gov (United States)

    Mark D. Nelson; Janine M. Benyus; Richard R. Buech

    1992-01-01

    Wildlife habitat data from seven Great Lakes National Forests were combined into a wildlife-habitat matrix named NORTHWOODS. Several electronic file formats of NORTHWOODS data base and documentation are available on floppy disks for microcomputers.

  12. GCCS Spatial Data Base Module

    National Research Council Canada - National Science Library

    Bell, Paul

    1998-01-01

    .... JMTK is divided into three primary areas: (1) Visual, (2) Analysis (non-visual), and (3) Spatial Data Base (SDBM). The primary objective of the SDBM effort is to define, design, develop and test mapping, charting and geodesy...

  13. Surface stress-based biosensors.

    Science.gov (United States)

    Sang, Shengbo; Zhao, Yuan; Zhang, Wendong; Li, Pengwei; Hu, Jie; Li, Gang

    2014-01-15

    Surface stress-based biosensors, as one kind of label-free biosensors, have attracted lots of attention in the process of information gathering and measurement for the biological, chemical and medical application with the development of technology and society. This kind of biosensors offers many advantages such as short response time (less than milliseconds) and a typical sensitivity at nanogram, picoliter, femtojoule and attomolar level. Furthermore, it simplifies sample preparation and testing procedures. In this work, progress made towards the use of surface stress-based biosensors for achieving better performance is critically reviewed, including our recent achievement, the optimally circular membrane-based biosensors and biosensor array. The further scientific and technological challenges in this field are also summarized. Critical remark and future steps towards the ultimate surface stress-based biosensors are addressed. Copyright © 2013 Elsevier B.V. All rights reserved.

  14. Chip-based droplet sorting

    Science.gov (United States)

    Beer, Neil Reginald; Lee, Abraham; Hatch, Andrew

    2017-11-21

    A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting.

  15. Cage-based performance capture

    CERN Document Server

    Savoye, Yann

    2014-01-01

    Nowadays, highly-detailed animations of live-actor performances are increasingly easier to acquire and 3D Video has reached considerable attentions in visual media production. In this book, we address the problem of extracting or acquiring and then reusing non-rigid parametrization for video-based animations. At first sight, a crucial challenge is to reproduce plausible boneless deformations while preserving global and local captured properties of dynamic surfaces with a limited number of controllable, flexible and reusable parameters. To solve this challenge, we directly rely on a skin-detached dimension reduction thanks to the well-known cage-based paradigm. First, we achieve Scalable Inverse Cage-based Modeling by transposing the inverse kinematics paradigm on surfaces. Thus, we introduce a cage inversion process with user-specified screen-space constraints. Secondly, we convert non-rigid animated surfaces into a sequence of optimal cage parameters via Cage-based Animation Conversion. Building upon this re...

  16. FEMA DFIRM Base Flood Elevations

    Data.gov (United States)

    Minnesota Department of Natural Resources — The Base Flood Elevation (BFE) table is required for any digital data where BFE lines will be shown on the corresponding Flood Insurance Rate Map (FIRM). Normally,...

  17. Consent Based Verification System (CBSV)

    Data.gov (United States)

    Social Security Administration — CBSV is a fee-based service offered by SSA's Business Services Online (BSO). It is used by private companies to verify the SSNs of their customers and clients that...

  18. Microprocessor based techniques at CESR

    International Nuclear Information System (INIS)

    Giannini, G.; Cornell Univ., Ithaca, NY

    1981-01-01

    Microprocessor based systems succesfully used in connection with the High Energy Physics experimental program at the Cornell Electron Storage Ring are described. The multiprocessor calibration system for the CUSB calorimeter is analyzed in view of present and future applications. (orig.)

  19. Consumption-based Equity Valuation

    DEFF Research Database (Denmark)

    Bach, Christian; Christensen, Peter Ove

    2013-01-01

    Using a CCAPM-based risk-adjustment model consistent with general asset pricing theory, we perform yearly valuations of a large sample of stocks listed on NYSE, AMEX and NASDAQ over a thirty-year period. The model differs from standard valuation models in the sense that it adjusts forecasted...... residual income for risk in the numerator rather than through a risk-adjusted cost of equity in the denominator. The risk-adjustments are derived based on assumptions about the time-series properties of residual income returns and aggregate consumption rather than on historical stock returns. We compare...... the performance of the model with several implementations of standard valuation models, both in terms of absolute valuation errors, and in terms of the returns on simple investment strategies based on the differences between model and market prices in the respective valuation models. The CCAPM-based valuation...

  20. Base compaction specification feasibility analysis.

    Science.gov (United States)

    2012-12-01

    The objective of this research is to establish the technical engineering and cost : analysis concepts that will enable WisDOT management to objectively evaluate the : feasibility of switching construction specification philosophies for aggregate base...