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Sample records for bars affect lipid

  1. Additions of caffeic acid, ascorbyl palmitate or gamma-tocopherol to fish oil-enriched energy bars affect lipid oxidation differently

    DEFF Research Database (Denmark)

    Horn, Anna Frisenfeldt; Nielsen, Nina Skall; Jacobsen, Charlotte

    2009-01-01

    The objectives of the study were to investigate the effects of caffeic acid, ascorbyl palmitate and gamma-tocopherol on protection of fish oil-enriched energy bars against lipid oxidation during storage for 10 weeks at room temperature. The lipophilic gamma-tocopherol reduced lipid oxidation during......, or the hydrophilic caffeic acid, or the amphiphilic ascorbyl palmitate at concentrations of 75, 150 and 300 mu g/g fish oil. Prooxidative effects were observed as an increase in the formation of lipid hydroperoxides and volatile secondary oxidation products, as well as the development of rancid off...

  2. Membrane-Sculpting BAR Domains Generate Stable Lipid Microdomains

    Science.gov (United States)

    Zhao, Hongxia; Michelot, Alphée; Koskela, Essi V.; Tkach, Vadym; Stamou, Dimitrios; Drubin, David G.; Lappalainen, Pekka

    2014-01-01

    SUMMARY Bin-Amphiphysin-Rvs (BAR) domain proteins are central regulators of many cellular processes involving membrane dynamics. BAR domains sculpt phosphoinositide-rich membranes to generate membrane protrusions or invaginations. Here, we report that, in addition to regulating membrane geometry, BAR domains can generate extremely stable lipid microdomains by “freezing” phosphoinositide dynamics. This is a general feature of BAR domains, because the yeast endocytic BAR and Fes/CIP4 homology BAR (F-BAR) domains, the inverse BAR domain of Pinkbar, and the eisosomal BAR protein Lsp1 induced phosphoinositide clustering and halted lipid diffusion, despite differences in mechanisms of membrane interactions. Lsp1 displays comparable low diffusion rates in vitro and in vivo, suggesting that BAR domain proteins also generate stable phosphoinositide microdomains in cells. These results uncover a conserved role for BAR superfamily proteins in regulating lipid dynamics within membranes. Stable microdomains induced by BAR domain scaffolds and specific lipids can generate phase boundaries and diffusion barriers, which may have profound impacts on diverse cellular processes. PMID:24055060

  3. Membrane-sculpting BAR domains generate stable lipid microdomains

    DEFF Research Database (Denmark)

    Zhao, Hongxia; Michelot, Alphée; Koskela, Essi V.; Tkach, Vadym; Stamou, Dimitrios; Drubin, David G.; Lappalainen, Pekka

    2013-01-01

    Bin-Amphiphysin-Rvs (BAR) domain proteins are central regulators of many cellular processes involving membrane dynamics. BAR domains sculpt phosphoinositide-rich membranes to generate membrane protrusions or invaginations. Here, we report that, in addition to regulating membrane geometry, BAR dom...

  4. Spastin binds to lipid droplets and affects lipid metabolism.

    Directory of Open Access Journals (Sweden)

    Chrisovalantis Papadopoulos

    2015-04-01

    Full Text Available Mutations in SPAST, encoding spastin, are the most common cause of autosomal dominant hereditary spastic paraplegia (HSP. HSP is characterized by weakness and spasticity of the lower limbs, owing to progressive retrograde degeneration of the long corticospinal axons. Spastin is a conserved microtubule (MT-severing protein, involved in processes requiring rearrangement of the cytoskeleton in concert to membrane remodeling, such as neurite branching, axonal growth, midbody abscission, and endosome tubulation. Two isoforms of spastin are synthesized from alternative initiation codons (M1 and M87. We now show that spastin-M1 can sort from the endoplasmic reticulum (ER to pre- and mature lipid droplets (LDs. A hydrophobic motif comprised of amino acids 57 through 86 of spastin was sufficient to direct a reporter protein to LDs, while mutation of arginine 65 to glycine abolished LD targeting. Increased levels of spastin-M1 expression reduced the number but increased the size of LDs. Expression of a mutant unable to bind and sever MTs caused clustering of LDs. Consistent with these findings, ubiquitous overexpression of Dspastin in Drosophila led to bigger and less numerous LDs in the fat bodies and increased triacylglycerol levels. In contrast, Dspastin overexpression increased LD number when expressed specifically in skeletal muscles or nerves. Downregulation of Dspastin and expression of a dominant-negative variant decreased LD number in Drosophila nerves, skeletal muscle and fat bodies, and reduced triacylglycerol levels in the larvae. Moreover, we found reduced amount of fat stores in intestinal cells of worms in which the spas-1 homologue was either depleted by RNA interference or deleted. Taken together, our data uncovers an evolutionarily conserved role of spastin as a positive regulator of LD metabolism and open up the possibility that dysfunction of LDs in axons may contribute to the pathogenesis of HSP.

  5. Mechanics of lipid bilayer junctions affecting the size of a connecting lipid nanotube

    OpenAIRE

    Voinova Marina; Kurczy Michael; Cans Ann-Sofie; Adams Kelly; Grzhibovskis Richards; Karlsson Roger; Ewing Andrew

    2011-01-01

    Abstract In this study we report a physical analysis of the membrane mechanics affecting the size of the highly curved region of a lipid nanotube (LNT) that is either connected between a lipid bilayer vesicle and the tip of a glass microinjection pipette (tube-only) or between a lipid bilayer vesicle and a vesicle that is attached to the tip of a glass microinjection pipette (two-vesicle). For the tube-only configuration (TOC), a micropipette is used to pull a LNT into the interior of a surfa...

  6. Methods for reducing lipid oxidation in fish-oil-enriched energy bars

    DEFF Research Database (Denmark)

    Nielsen, Nina Skall; Jacobsen, Charlotte

    2009-01-01

    5% FO. Heating of bars during baking did, apparently, not increase oxidation. Energy bars produced with neat FO were oxidatively unstable as measured by peroxide value, secondary volatile oxidation products and sensory analysis. Pre-emulsification of the FO with sodium caseinate in water offered...

  7. The choice of homogenisation equipment affects lipid oxidation in emulsions

    DEFF Research Database (Denmark)

    Horn, Anna Frisenfeldt; Nielsen, Nina Skall; Jensen, Louise Helene Søgaard;

    2012-01-01

    Milk proteins are often used by the food industry because of their good emulsifying properties. In addition, they can also provide oxidative stability to foods. However, different milk proteins or protein components have been shown to differ in their antioxidative properties, and their localisation...... in emulsions has been shown to be affected by the emulsification conditions. The objective of this study was to investigate the influence of homogenisation equipment (microfluidizer vs. two-stage valve homogeniser) on lipid oxidation in 10% fish oil-in-water emulsions prepared with two different milk...

  8. Lipidome analysis reveals antifungal polyphenol curcumin affects membrane lipid homeostasis.

    Science.gov (United States)

    Sharma, Monika; Dhamgaye, Sanjiveeni; Singh, Ashutosh; Prasad, Rajendra

    2012-01-01

    This study shows that antifungal curcumin (CUR), significantly depletes ergosterol levels in Candida albicans. CUR while displaying synergy with fluconazole (FLC) lowers ergosterol. However, CUR alone at its synergistic concentration (lower than MIC50), could not affect ergosterol contents. For deeper insight of CUR effects on lipids, we performed high throughput mass spectroscopy (MS) based lipid profiling of C. albicans cells. The lipidome analysis revealed that there were no major changes in phosphoglycerides (PGLs) composition following CUR treatment of Candida, however, significant differences in molecular species of PGLs were detected. Among major SPLs, CUR treatment resulted in the reduction of ceramide and accumulation of IPCs levels. The lipidome of CUR treated cells confirmed a dramatic drop in the ergosterol levels with a simultaneous accumulation of its biosynthetic precursors. This was further supported by the fact that the mutants defective in ergosterol biosynthesis (ERG2 and ERG11) and those lacking the transcription factor regulating ergosterol biosynthesis, UPC2, were highly susceptible to CUR. Our study first time shows that CUR, for its antifungal activity, targets and down regulates delta 5, 6 desaturase (ERG3) resulting in depletion of ergosterol. This results in parallel accumulation of ergosterol biosynthetic precursors, generation of reactive oxygen species (ROS) and cell death. PMID:22201946

  9. An Onion Byproduct Affects Plasma Lipids in Healthy Rats

    DEFF Research Database (Denmark)

    Roldan-Marin, E.; Jensen, R. I.; Krath, Britta;

    2010-01-01

    that the controls could be completely separated from OBP, OE, and OR groups in the scores plot and also that OE and OR groups were separated. Plasma lipids and bile acid excretion were the discriminating loading factors for separating OE and OR but also contributed to the separation of onion......Onion may contribute to the health effects associated with high fruit and vegetable consumption. A considerable amount of onion production ends up as waste that might find use in foods. Onion byproduct has not yet been explored for potential health benefits. The aim of this study is to elucidate...... the safety and potential role of onion byproducts in affecting risk markers of cardiovascular disease (CVD). For that purpose, the effects of an onion byproduct, Allium cepa L. cepa 'Recas' (OBP), and its two derived fractions, an ethanolic extract (OE) and a residue (OR), on the distribution of...

  10. Mechanics of lipid bilayer junctions affecting the size of a connecting lipid nanotube

    Science.gov (United States)

    Karlsson, Roger; Kurczy, Michael; Grzhibovskis, Richards; Adams, Kelly L.; Ewing, Andrew G.; Cans, Ann-Sofie; Voinova, Marina V.

    2011-06-01

    In this study we report a physical analysis of the membrane mechanics affecting the size of the highly curved region of a lipid nanotube (LNT) that is either connected between a lipid bilayer vesicle and the tip of a glass microinjection pipette (tube-only) or between a lipid bilayer vesicle and a vesicle that is attached to the tip of a glass microinjection pipette (two-vesicle). For the tube-only configuration (TOC), a micropipette is used to pull a LNT into the interior of a surface-immobilized vesicle, where the length of the tube L is determined by the distance of the micropipette to the vesicle wall. For the two-vesicle configuration (TVC), a small vesicle is inflated at the tip of the micropipette tip and the length of the tube L is in this case determined by the distance between the two interconnected vesicles. An electrochemical method monitoring diffusion of electroactive molecules through the nanotube has been used to determine the radius of the nanotube R as a function of nanotube length L for the two configurations. The data show that the LNT connected in the TVC constricts to a smaller radius in comparison to the tube-only mode and that tube radius shrinks at shorter tube lengths. To explain these electrochemical data, we developed a theoretical model taking into account the free energy of the membrane regions of the vesicles, the LNT and the high curvature junctions. In particular, this model allows us to estimate the surface tension coefficients from R( L) measurements.

  11. Mechanics of lipid bilayer junctions affecting the size of a connecting lipid nanotube

    Directory of Open Access Journals (Sweden)

    Voinova Marina

    2011-01-01

    Full Text Available Abstract In this study we report a physical analysis of the membrane mechanics affecting the size of the highly curved region of a lipid nanotube (LNT that is either connected between a lipid bilayer vesicle and the tip of a glass microinjection pipette (tube-only or between a lipid bilayer vesicle and a vesicle that is attached to the tip of a glass microinjection pipette (two-vesicle. For the tube-only configuration (TOC, a micropipette is used to pull a LNT into the interior of a surface-immobilized vesicle, where the length of the tube L is determined by the distance of the micropipette to the vesicle wall. For the two-vesicle configuration (TVC, a small vesicle is inflated at the tip of the micropipette tip and the length of the tube L is in this case determined by the distance between the two interconnected vesicles. An electrochemical method monitoring diffusion of electroactive molecules through the nanotube has been used to determine the radius of the nanotube R as a function of nanotube length L for the two configurations. The data show that the LNT connected in the TVC constricts to a smaller radius in comparison to the tube-only mode and that tube radius shrinks at shorter tube lengths. To explain these electrochemical data, we developed a theoretical model taking into account the free energy of the membrane regions of the vesicles, the LNT and the high curvature junctions. In particular, this model allows us to estimate the surface tension coefficients from R(L measurements.

  12. Factors affecting Archaeal Lipid Compositions of the Sulfolobus Species

    Science.gov (United States)

    He, L.; Han, J.; Wei, Y.; Lin, L.; Wei, Y.; Zhang, C.

    2010-12-01

    Temperature is the best known variable affecting the distribution of the archaeal glycerol dibiphytanyl glycerol tetraethers (GDGTs) in marine and freshwater systems. Other variables such as pH, ionic strength, or bicarbonate concentration may also affect archaeal GDGTs in terrestrial systems. Studies of pure cultures can help us pinpoint the specific effects these variables may have on archaeal lipid distribution in natural environments. In this study, three Sulfolobus species (HG4, HB5-2, HB9-6) isolated from Tengchong hot springs (pH 2-3, temperature 73-90°C) in China were used to investigate the effects of temperature, pH, substrate, and type of strain on the composition of GDGTs. Results showed that increase in temperature had negative effects on the relative contents of GDGT-0 (no cyclopentyl rings), GDGT-1 (one cyclopentyl ring), GDGT-2 and GDGT-3 but positive effects on GDGT-4, GDGT-4', GDGT-5 and GDGT-5'. Increase in pH, on the other hand, had negative effects on GDGT-0, GDGT-1, GDGT-4', GDGT-5 and GDGT-5', and positive effects on GDGT-3 and GDGT-4. GDGT-2 remained relatively constant with changing pH. When the HG4 was grown on different substrates, GDGT-5 was five time more abundant in sucrose-grown cultures than in yeast extract- or sulfur- grown cultures, suggesting that carbohydrates may stimulate the production of GDGT-5. For all three species, the ring index (average number of rings) of GDGTs correlated positively with incubation temperature. In HG4, ring index was much lower at optimal pH (3.5) than at other pH values. Ring index of HB5-2 or HB9-6 is higher than that of HG4, suggesting that speciation may affect the degree of cyclization of GDGT of the Sulfolobus. These results indicate that individual archaeal lipids respond differently to changes in environmental variables, which may be also species specific.

  13. Scoparone affects lipid metabolism in primary hepatocytes using lipidomics.

    Science.gov (United States)

    Zhang, Aihua; Qiu, Shi; Sun, Hui; Zhang, Tianlei; Guan, Yu; Han, Ying; Yan, Guangli; Wang, Xijun

    2016-01-01

    Lipidomics, which focuses on the global study of molecular lipids in biological systems, could provide valuable insights about disease mechanisms. In this study, we present a nontargeted lipidomics strategy to determine cellular lipid alterations after scoparone exposure in primary hepatocytes. Lipid metabolic profiles were analyzed by high-performance liquid chromatography coupled with time-of-flight mass spectrometry, and a novel imaging TransOmics tool has been developed for the analysis of high-resolution MS data, including the data pretreatment, visualization, automated identification, deconvolution and quantification of lipid species. Chemometric and statistical analyses of the obtained lipid fingerprints revealed the global lipidomic alterations and tested the therapeutic effects of scoparone. Identification of ten proposed lipids contributed to the better understanding of the effects of scoparone on lipid metabolism in hepatocytes. The most striking finding was that scoparone caused comprehensive lipid changes, as represented by significant changes of the identificated lipids. The levels of identified PG(19:1(9Z)/14:0), PE(17:1(9Z)/0:0), PE(19:1(9Z)/0:0) were found to be upregulated in ethanol-induced group, whereas the levels in scoparone group were downregulated. Lipid metabolism in primary hepatocytes was changed significantly by scoparone treatment. We believe that this novel approach could substantially broaden the applications of high mass resolution mass spectrometry for cellular lipidomics. PMID:27306123

  14. Prenatal hyperandrogenism induces alterations that affect liver lipid metabolism.

    Science.gov (United States)

    Abruzzese, Giselle Adriana; Heber, Maria Florencia; Ferreira, Silvana Rocio; Velez, Leandro Martin; Reynoso, Roxana; Pignataro, Omar Pedro; Motta, Alicia Beatriz

    2016-07-01

    Prenatal hyperandrogenism is hypothesized as one of the main factors contributing to the development of polycystic ovary syndrome (PCOS). PCOS patients have high risk of developing fatty liver and steatosis. This study aimed to evaluate the role of prenatal hyperandrogenism in liver lipid metabolism and fatty liver development. Pregnant rats were hyperandrogenized with testosterone. At pubertal age, the prenatally hyperandrogenized (PH) female offspring displayed both ovulatory (PHov) and anovulatory (PHanov) phenotypes that mimic human PCOS features. We evaluated hepatic transferases, liver lipid content, the balance between lipogenesis and fatty acid oxidation pathway, oxidant/antioxidant balance and proinflammatory status. We also evaluated the general metabolic status through growth rate curve, basal glucose and insulin levels, glucose tolerance test, HOMA-IR index and serum lipid profile. Although neither PH group showed signs of liver lipid content, the lipogenesis and fatty oxidation pathways were altered. The PH groups also showed impaired oxidant/antioxidant balance, a decrease in the proinflammatory pathway (measured by prostaglandin E2 and cyclooxygenase-2 levels), decreased glucose tolerance, imbalance of circulating lipids and increased risk of metabolic syndrome. We conclude that prenatal hyperandrogenism generates both PHov and PHanov phenotypes with signs of liver alterations, imbalance in lipid metabolism and increased risk of developing metabolic syndrome. The anovulatory phenotype showed more alterations in liver lipogenesis and a more impaired balance of insulin and glucose metabolism, being more susceptible to the development of steatosis. PMID:27179108

  15. Investigation of Molecular Marker Lipids in Alpine Ice Cores Via Stir Bar Sorptive Extraction

    Science.gov (United States)

    Makou, M. C.; Eglinton, T. I.; Thompson, L. G.; Hughen, K. A.

    2005-12-01

    Recently developed analytical techniques were employed to identify and quantify organic molecular markers trapped in high-altitude ice. While various compounds represent potentially useful proxies for biomass burning, vegetation type, atmospheric circulation, and anthropogenic activity, prior attempts to measure organic compounds in ice cores have typically required large volumes of sample material that are incompatible with generation of high-resolution paleoclimate records. We employed stir bar sorptive extraction (SBSE) and thermal desorption (TD), coupled with gas chromatography/time-of-flight mass spectrometry (GC/TOF-MS), to examine the organic content of small quantities (≤ 30 ml) of ice. To test the utility of the approach, post-industrial ice core samples from the Huascarán and Sajama sites (Andes), the Dasuopu and Puruogangri sites (Tibetan Plateau), and Mt. Kilimanjaro (east Africa) were tested. n-Alkanes, n-alkanoic acids, n-alkyl amides and nitriles, polycyclic aromatic hydrocarbons (PAHs), and various diterpenoids were identified in this suite of cores. These marker compounds suggest inputs from biomass burning, fresh vascular plant material, and anthropogenic activities such as fossil fuel combustion. Differences in distributions of the alkyl amide and nitrile homologues between the different sites suggest a predominantly local or regional supply of organic matter. Pre-industrial samples from the Sajama and Puruogangri ice cores were also analyzed in order to assess the character of biomarker assemblages in the absence of anthropogenic contributions and investigate changes in inputs over time. PAHs and diterpenoids, which may result from biomass burning and were observed in the modern Sajama samples, occurred in two Holocene Sajama samples, but not in a last glacial sample. Enhanced inputs of terrestrial vegetation combustion biomarkers were consistent with periods of enhanced aridity in both cores. This study demonstrates the utility of SBSE, TD

  16. The Effects of Long-Term Feeding of Rodent Food Bars on Lipid Peroxidation And Antioxidant Enzyme Levels In Fisher Rats

    Science.gov (United States)

    Ramirez, Joel; Zirkle-Yoshida, M.; Piert, S.; Barrett, J.; Yul, D.; Dalton, B.; Girten, B.

    2001-01-01

    A specialized rodent food bar diet has been developed and utilized successfully for short-duration shuttle missions. Recent tests conducted in preparation for experiments aboard the International Space Station (ISS) indicated that long-term food bar feeding for three months induced hyperlipidemia in rats. This study examined oxidative stress status in livers of these same animals. Spectrophotometric analysis of 79 Fischer rat livers (40 female and 39 male) for lipid peroxidation (LPO) and superoxide dismutase (SOD) was conducted using Bioxytech LPO-587(TM) assay kit and SOD-525(Tm) assay kit, respectively. The treatment groups consisted of 20 male CHOW and 19 male FOOD BAR rats and 20 female CHOW and 20 female FOOD BAR rats. Statistical analysis to compare differences between groups was performed by standard analysis of variance procedures. The male FOOD BAR group LPO mean (3.6 +/- 0.2 mmol/g) was significantly (p less than or equal to 0.05) greater than that of the male CHOW group (2.1 +/-0.1 mmol/g). Moreover the female FOOD BAR group LPO mean (2.9 +/-0.1 mmol/g) was also significantly greater than the female CHOW group mean (2.2 +/-0.1 mmol/g). The mean values for SOD in both male and female groups showed no significant differences between CHOW and FOOD BAR groups. These results show that LPO levels were significantly higher in both the male and female FOOD BAR groups compared to CHOW groups and that there was no concomitant increase in SOD levels across the group. In addition, males showed a greater difference than females in terms of LPO levels. These findings suggest a need for further investigation into the use of the current food bar formulation for long-term experiments such as those planned for the ISS.

  17. Does the type of CIA policy significantly affect bar and restaurant employment in Minnesota cities?

    Science.gov (United States)

    Klein, Elizabeth G.; Forster, Jean L.; Erickson, Darin J.; Lytle, Leslie A.; Schillo, Barbara

    2009-01-01

    Background Clean indoor air (CIA) policies that include free-standing bars and restaurants have been adopted by communities to protect employees in all workplaces from exposure to environmental tobacco smoke, most notably employees working in restaurants and free-standing bars. However, due to the perception of negative economic effects on alcohol-licensed hospitality businesses, partial CIA policies (those that provide an exemption for free-standing bars) have been proposed as a means to reduce the risk of economic effects of comprehensive CIA policies applied to all worksites. Objective To determine if partial CIA produce differential economic effects compared to comprehensive CIA policies using bar and restaurant employment per capita. Design, setting, and subjects Ten cities in the state of Minnesota were studied from 2003 to 2006. Economic data were drawn from monthly employment in bars and restaurants, and a pooled time-series was completed to evaluate three types of local CIA policies: Comprehensive, partial, or none beyond the state law. Results Communities with a comprehensive CIA policy had a decrease of 9 employees per 10,000 residents compared with communities with a partial CIA policies (p=0.10). Communities with any type of CIA policy (partial or comprehensive) had an increase of 3 employees per 10,000 residents compared to communities without any CIA policies (p=0.36). Conclusion There were no significant differential economic effects by CIA policy type in Minnesota cities. These findings support the adoption of comprehensive CIA policies to provide all employees protection from environmental tobacco smoke exposure. PMID:19184432

  18. Miltefosine Affects Lipid Metabolism in Leishmania donovani Promastigotes▿

    OpenAIRE

    Rakotomanga, M.; Blanc, S.; Gaudin, K.; Chaminade, P.; Loiseau, P.M.

    2007-01-01

    Miltefosine (hexadecylphosphocholine [HePC]) is the first orally active antileishmanial drug. Transient HePC treatment of Leishmania donovani promastigotes at 10 μM significantly reduced the phosphatidylcholine content and enhanced the phosphatidylethanolamine (PE) content in parasite membranes, suggesting a partial inactivation of PE-N-methyltransferase. Phospholipase D activity did not seem to be affected by HePC. In addition, the enhancement of the lysophosphatidylcholine content could be ...

  19. Effect of Lipid Partitioning on Predictions of Acute Toxicity of Oil Sands Process Affected Water to Embryos of Fathead Minnow (Pimephales promelas).

    Science.gov (United States)

    Morandi, Garrett D; Zhang, Kun; Wiseman, Steve B; Pereira, Alberto Dos Santos; Martin, Jonathan W; Giesy, John P

    2016-08-16

    Dissolved organic compounds in oil sands process affected water (OSPW) are known to be responsible for most of its toxicity to aquatic organisms, but the complexity of this mixture prevents use of traditional bottom-up approaches for predicting toxicities of mixtures. Therefore, a top-down approach to predict toxicity of the dissolved organic fraction of OSPW was developed and tested. Accurate masses (i.e., m/z) determined by ultrahigh resolution mass spectrometry in negative and positive ionization modes were used to assign empirical chemical formulas to each chemical species in the mixture. For each chemical species, a predictive measure of lipid accumulation was estimated by stir-bar sorptive extraction (SBSE) to poly(dimethyl)siloxane, or by partitioning to solid-supported lipid membranes (SSLM). A narcosis mode of action was assumed and the target-lipid model was used to estimate potencies of mixtures by assuming strict additivity. A model developed using a combination of the SBSE and SSLM lipid partitioning estimates, whereby the accumulation of chemicals to neutral and polar lipids was explicitly considered, was best for predicting empirical values of LC50 in 96-h acute toxicity tests with embryos of fathead minnow (Pimephales promelas). Model predictions were within 4-fold of observed toxicity for 75% of OSPW samples, and within 8.5-fold for all samples tested, which is comparable to the range of interlaboratory variability for in vivo toxicity testing. PMID:27420640

  20. Mechanisms affecting performance of the BaBar resistive plate chambers and searches for remediation

    International Nuclear Information System (INIS)

    The BaBar experiment at PEPII relies on the instrumentation of the flux return (IFR) for both muon identification and KL detection. The active detector is composed of resistive plate chambers (RPCs) operated in streamer mode. Since the start of operation the RPCs have suffered persistent efficiency deterioration and dark current increase problems. The 'autopsy' of bad BaBar RPCs revealed that in many cases uncured linseed oil droplets had formed on the inner surface of the Bakelite plates, leading to current paths from oil 'stalagmites' bridging the 2 mm gap. In this paper, a possible model of this 'stalagmite' formation and its effect on the dark current and efficiency of RPC chambers is presented. Laboratory test results strongly support this model. Based upon this model we are searching for solutions to eliminate the unfavorable effect of the oil stalagmites. The lab tests show that the stalagmite resistivity increases dramatically if exposed to the air, an observation that points to a possible way to remedy the damage and increase the efficiency. We have seen that flowing an oxygen gas mixture into the chamber helps to polymerize the uncured linseed oil. Consequently, the resistivity of the bridged oil stalagmites increases, as does that of the oil coating on the frame edges and spacers, significantly reducing the RPC dark currents and low-efficiency regions. We have tested this idea on two chambers removed from BaBar because of their low efficiency and high dark current. These test results are reported in the paper, and two other remediation methods also mentioned. We continue to study this problem, and try to find new treatments with permanent improvement

  1. Providing lipid-based nutrient supplements does not affect developmental milestones among Malawian children

    Science.gov (United States)

    Our objective was to assess whether using lipid-based nutrient supplements (LNS) to complement the diets of infants and young children affected when they achieved selected developmental milestones. In rural Malawi, 840 6-month-old healthy infants were enrolled to a randomised trial. Control particip...

  2. Dietary lipid and gross energy affect protein utilization in the rare minnow Gobiocypris rarus

    Science.gov (United States)

    Wu, Benli; Xiong, Xiaoqin; Xie, Shouqi; Wang, Jianwei

    2015-10-01

    An 8-week feeding trial was conducted to detect the optimal dietary protein and energy, as well as the effects of protein to energy ratio on growth, for the rare minnow (Gobiocypris rarus), which are critical to nutrition standardization for model fish. Twenty-four diets were formulated to contain three gross energy (10, 12.5, 15 kJ/g), four protein (20%, 25%, 30%, 35%), and two lipid levels (3%, 6%). The results showed that optimal dietary E/P was 41.7-50 kJ/g for maximum growth in juvenile rare minnows at 6% dietary crude lipid. At 3% dietary lipid, specific growth rate (SGR) increased markedly when E/P decreased from 62.5 kJ/g to 35.7 kJ/g and gross energy was 12.5 kJ/g, and from 75 kJ/g to 42.9 kJ/g when gross energy was 15.0 kJ/g. The optimal gross energy was estimated at 12.5 kJ/g and excess energy decreased food intake and growth. Dietary lipid exhibited an apparent protein-sparing effect. Optimal protein decreased from 35% to 25%-30% with an increase in dietary lipid from 3% to 6% without adversely effecting growth. Dietary lipid level affects the optimal dietary E/P ratio. In conclusion, recommended dietary protein and energy for rare minnow are 20%-35% and 10-12.5 kJ/g, respectively.

  3. Dietary lipid and gross energy affect protein utilization in the rare minnow Gobiocypris rarus

    Science.gov (United States)

    Wu, Benli; Xiong, Xiaoqin; Xie, Shouqi; Wang, Jianwei

    2016-07-01

    An 8-week feeding trial was conducted to detect the optimal dietary protein and energy, as well as the effects of protein to energy ratio on growth, for the rare minnow ( Gobiocypris rarus), which are critical to nutrition standardization for model fish. Twenty-four diets were formulated to contain three gross energy (10, 12.5, 15 kJ/g), four protein (20%, 25%, 30%, 35%), and two lipid levels (3%, 6%). The results showed that optimal dietary E/P was 41.7-50 kJ/g for maximum growth in juvenile rare minnows at 6% dietary crude lipid. At 3% dietary lipid, specific growth rate (SGR) increased markedly when E/P decreased from 62.5 kJ/g to 35.7 kJ/g and gross energy was 12.5 kJ/g, and from 75 kJ/g to 42.9 kJ/g when gross energy was 15.0 kJ/g. The optimal gross energy was estimated at 12.5 kJ/g and excess energy decreased food intake and growth. Dietary lipid exhibited an apparent protein-sparing effect. Optimal protein decreased from 35% to 25%-30% with an increase in dietary lipid from 3% to 6% without adversely effecting growth. Dietary lipid level affects the optimal dietary E/P ratio. In conclusion, recommended dietary protein and energy for rare minnow are 20%-35% and 10-12.5 kJ/g, respectively.

  4. Migratory refueling affects non-enzymatic antioxidant capacity, but does not increase lipid peroxidation.

    Science.gov (United States)

    Eikenaar, Cas; Jönsson, Johanna; Fritzsch, Anna; Wang, Hong-Lei; Isaksson, Caroline

    2016-05-01

    All aerobic organisms are to some degree affected by oxidative stress, which is an imbalance between pro-oxidants and antioxidants in favor of the former. Pro-oxidants can damage DNA, proteins and lipids, and as such oxidative stress can carry considerably fitness costs. In mammals excessive calorie intake is a known cause of oxidative stress. We investigated whether in migrant birds, which typically engage in over-eating in between flights (refueling), high food intake causes oxidative stress. In an experiment we compared levels of plasmatic total non-enzymatic antioxidant capacity (AOX) and oxidative damage (lipid peroxidation) between migrants repeatedly fasted and refed (simulating the flight-refuel cycle of wild migrants), and migrants on ad libitum food. We found that refueling increased AOX, an effect mainly attributable to an increase in uric acid level, an antioxidant that is produced during protein metabolism. Accordingly, variation in AOX was mainly explained by the refueling birds' food intake. However, food intake in migrants on ad libitum food did not explain any variation in AOX. Refueling did not affect lipid peroxidation, nor were its levels explained by food intake. We propose that over-eating migrants retain uric acid, which might be a very low cost mechanism to forego oxidative damage. PMID:26921098

  5. Varying plant protein sources in the diet of sea bass Dicentrarchus labrax differently affects lipid metabolism and deposition

    Directory of Open Access Journals (Sweden)

    E. Tibaldi

    2010-04-01

    Full Text Available The liver activity of lipogenic enzymes, the lipid content in various tissues, and plasma lipid levels of major, were measured in sea bass (D. labrax fed over 96 days either a, fish meal-based control diet or preparations where 70% of fish meal protein was replaced by wheat gluten singly or in combination with pea or soybean meals. Relative to the controls, sea bass fed the wheat gluten-based diet resulted in stimulated lipogenesis in liver and increased lipid deposition in muscle. The opposite occurred when a substantial amount of soybean meal was included in the diet. Mesenteric fat depots were apparently insensitive to major changes in dietary protein source in fish showing similar intakes of digestible protein, energy and lipid. These results confirm that varying plant protein source in the diet differently affects lipid metabolism and deposition in sea bass.

  6. Lung inflammation does not affect the clearance kinetics of lipid nanocapsules following pulmonary administration.

    Science.gov (United States)

    Patel, Aateka; Woods, A; Riffo-Vasquez, Yanira; Babin-Morgan, Anna; Jones, Marie-Christine; Jones, Stuart; Sunassee, Kavitha; Clark, Stephen; T M de Rosales, Rafael; Page, Clive; Spina, Domenico; Forbes, Ben; Dailey, Lea Ann

    2016-08-10

    Lipid nanocapsules (LNCs) are semi-rigid spherical capsules with a triglyceride core that present a promising formulation option for the pulmonary delivery of drugs with poor aqueous solubility. Whilst the biodistribution of LNCs of different size has been studied following intravenous administration, the fate of LNCs following pulmonary delivery has not been reported. We investigated quantitatively whether lung inflammation affects the clearance of 50nm lipid nanocapsules, or is exacerbated by their pulmonary administration. Studies were conducted in mice with lipopolysaccharide-induced lung inflammation compared to healthy controls. Particle deposition and nanocapsule clearance kinetics were measured by single photon emission computed tomography/computed tomography (SPECT/CT) imaging over 48 h. A significantly lower lung dose of (111)In-LNC50 was achieved in the lipopolysaccharide (LPS)-treated animals compared with healthy controls (p<0.001). When normalised to the delivered lung dose, the clearance kinetics of (111)In-LNC50 from the lungs fit a first order model with an elimination half-life of 10.5±0.9h (R(2)=0.995) and 10.6±0.3h (R(2)=1.000) for healthy and inflamed lungs respectively (n=3). In contrast, (111)In-diethylene triamine pentaacetic acid (DTPA), a small hydrophilic molecule, was cleared rapidly from the lungs with the majority of the dose absorbed within 20min of administration. Biodistribution to lungs, stomach-intestine, liver, trachea-throat and blood at the end of the imaging period was unaltered by lung inflammation. This study demonstrated that lung clearance and whole body distribution of lipid nanocapsules were unaffected by the presence of acute lung inflammation. PMID:27180635

  7. Environmentally Relevant Dose of Bisphenol A Does Not Affect Lipid Metabolism and Has No Synergetic or Antagonistic Effects on Genistein’s Beneficial Roles on Lipid Metabolism

    Science.gov (United States)

    Fan, Ying; Li, Hongyu; Zhao, Nana; Yang, Huiqin; Ye, Xiaolei; He, Dongliang; Yang, Hui; Jin, Xin; Tian, Chong; Ying, Chenjiang

    2016-01-01

    Both bisphenol A (BPA, an endocrine disrupting chemicals) and genistein (a phytoestrogen mainly derived from leguminosae) are able to bind to estrogen receptors, but they are considered to have different effects on metabolic syndrome, surprisingly. We here investigate the effects of an environmentally relevant dose of BPA alone and the combined effects with genistein on lipid metabolism in rats. Eight groups of adult male Wistar rats, fed with either standard chow diet or high-fat diet, were treated with BPA (50μg/kg/day), genistein (10mg/kg/day), and BPA plus genistein for 35 weeks, respectively. Metabolic parameters in serum and liver were determined; the hematoxylin/eosin and oil Red O staining were used to observe liver histologically; gene expressions related to hepatic lipid metabolism were analyzed by Real-time PCR; protein expressions of PPARγ, PPARα and LC3 in liver were analyzed by western blotting. No difference of body weight gain, total energy intake, liver weight/body weight or body fat percentage in both STD- and HFD-fed sub-groups was observed after treatment with BPA, genistein, or BPA plus genistein (P>0.05). Genistein alleviated lipid metabolism disorder and decreased the mRNA and protein expression of PPARγ (P0.05) or combined with genistein. Our findings suggest that long-term environmentally relevant dose of BPA did not affect lipid metabolism, and had no synergetic or antagonistic roles on genistein’s beneficial function on hepatic lipid metabolism. PMID:27171397

  8. Nonbilayer lipids affect peripheral and integral membrane proteins via changes in the lateral pressure profile.

    Science.gov (United States)

    van den Brink-van der Laan, Els; Killian, J Antoinette; de Kruijff, Ben

    2004-11-01

    Nonbilayer lipids can be defined as cone-shaped lipids with a preference for nonbilayer structures with a negative curvature, such as the hexagonal phase. All membranes contain these lipids in large amounts. Yet, the lipids in biological membranes are organized in a bilayer. This leads to the question: what is the physiological role of nonbilayer lipids? Different models are discussed in this review, with a focus on the lateral pressure profile within the membrane. Based on this lateral pressure model, predictions can be made for the effect of nonbilayer lipids on peripheral and integral membrane proteins. Recent data on the catalytic domain of Leader Peptidase and the potassium channel KcsA are discussed in relation to these predictions and in relation to the different models on the function of nonbilayer lipids. The data suggest a general mechanism for the interaction between nonbilayer lipids and membrane proteins via the membrane lateral pressure. PMID:15519321

  9. Osmotic and curvature stress affect PEG-induced fusion of lipid vesicles but not mixing of their lipids.

    OpenAIRE

    Malinin, Vladimir S.; Frederik, Peter; Lentz, Barry R

    2002-01-01

    Poly (ethylene glycol) (PEG) in the external environment of membrane vesicles creates osmotic imbalance that leads to mechanical stress in membranes and may induce local membrane curvature. To determine the relative importance of membrane stress and curvature in promoting fusion, we monitored contents mixing (CM) and lipid mixing (LM) between different sized vesicles under a variety of osmotic conditions. CM between highly curved vesicles (SUV, 26 nm diameter) was up to 10 times greater than ...

  10. Imbalanced Hemolymph Lipid Levels Affect Feeding Motivation in the Two-Spotted Cricket, Gryllus bimaculatus

    Science.gov (United States)

    Konuma, Takahiro; Tsukamoto, Yusuke; Nagasawa, Hiromichi; Nagata, Shinji

    2016-01-01

    Insect feeding behavior is regulated by many intrinsic factors, including hemolymph nutrient levels. Adipokinetic hormone (AKH) is a peptide factor that modulates hemolymph nutrient levels and regulates the nutritional state of insects by triggering the transfer of lipids into the hemolymph. We recently demonstrated that RNA interference (RNAi)-mediated knockdown of the AKH receptor (AKHR) reduces hemolymph lipid levels, causing an increase in the feeding frequency of the two-spotted cricket, Gryllus bimaculatus. This result indicated that reduced hemolymph lipid levels might motivate crickets to feed. In the present study, to elucidate whether hemolymph lipid levels contribute to insect feeding behavior, we attempted to manipulate hemolymph lipid levels via the lipophorin (Lp)-mediated lipid transferring system in G. bimaculatus. Of the constituent proteins in Lp, we focused on apolipophorin-III (GrybiApoLp-III) because of its possible role in facilitating lipid mobilization. First, we used RNAi to reduce the expression of GrybiApoLp-III. RNAi-mediated knockdown of GrybiApoLp-III had little effect on basal hemolymph lipid levels and the amount of food intake. In addition, hemolymph lipid levels remained static even after injecting AKH into GrybiApoLp-IIIRNAi crickets. These observations indicated that ApoLp-III does not maintain basal hemolymph lipid levels in crickets fed ad libitum, but is necessary for mobilizing lipid transfer into the hemolymph following AKH stimulation. Second, Lp (containing lipids) was injected into the hemolymph to induce a temporary increase in hemolymph lipid levels. Consequently, the initiation of feeding was delayed in a dose-dependent manner, indicating that increased hemolymph lipid levels reduced the motivation to feed. Taken together, these data validate the importance of basal hemolymph lipid levels in the control of energy homeostasis and for regulating feeding behavior in crickets. PMID:27144650

  11. Imbalanced Hemolymph Lipid Levels Affect Feeding Motivation in the Two-Spotted Cricket, Gryllus bimaculatus.

    Directory of Open Access Journals (Sweden)

    Takahiro Konuma

    Full Text Available Insect feeding behavior is regulated by many intrinsic factors, including hemolymph nutrient levels. Adipokinetic hormone (AKH is a peptide factor that modulates hemolymph nutrient levels and regulates the nutritional state of insects by triggering the transfer of lipids into the hemolymph. We recently demonstrated that RNA interference (RNAi-mediated knockdown of the AKH receptor (AKHR reduces hemolymph lipid levels, causing an increase in the feeding frequency of the two-spotted cricket, Gryllus bimaculatus. This result indicated that reduced hemolymph lipid levels might motivate crickets to feed. In the present study, to elucidate whether hemolymph lipid levels contribute to insect feeding behavior, we attempted to manipulate hemolymph lipid levels via the lipophorin (Lp-mediated lipid transferring system in G. bimaculatus. Of the constituent proteins in Lp, we focused on apolipophorin-III (GrybiApoLp-III because of its possible role in facilitating lipid mobilization. First, we used RNAi to reduce the expression of GrybiApoLp-III. RNAi-mediated knockdown of GrybiApoLp-III had little effect on basal hemolymph lipid levels and the amount of food intake. In addition, hemolymph lipid levels remained static even after injecting AKH into GrybiApoLp-IIIRNAi crickets. These observations indicated that ApoLp-III does not maintain basal hemolymph lipid levels in crickets fed ad libitum, but is necessary for mobilizing lipid transfer into the hemolymph following AKH stimulation. Second, Lp (containing lipids was injected into the hemolymph to induce a temporary increase in hemolymph lipid levels. Consequently, the initiation of feeding was delayed in a dose-dependent manner, indicating that increased hemolymph lipid levels reduced the motivation to feed. Taken together, these data validate the importance of basal hemolymph lipid levels in the control of energy homeostasis and for regulating feeding behavior in crickets.

  12. Imbalanced Hemolymph Lipid Levels Affect Feeding Motivation in the Two-Spotted Cricket, Gryllus bimaculatus.

    Science.gov (United States)

    Konuma, Takahiro; Tsukamoto, Yusuke; Nagasawa, Hiromichi; Nagata, Shinji

    2016-01-01

    Insect feeding behavior is regulated by many intrinsic factors, including hemolymph nutrient levels. Adipokinetic hormone (AKH) is a peptide factor that modulates hemolymph nutrient levels and regulates the nutritional state of insects by triggering the transfer of lipids into the hemolymph. We recently demonstrated that RNA interference (RNAi)-mediated knockdown of the AKH receptor (AKHR) reduces hemolymph lipid levels, causing an increase in the feeding frequency of the two-spotted cricket, Gryllus bimaculatus. This result indicated that reduced hemolymph lipid levels might motivate crickets to feed. In the present study, to elucidate whether hemolymph lipid levels contribute to insect feeding behavior, we attempted to manipulate hemolymph lipid levels via the lipophorin (Lp)-mediated lipid transferring system in G. bimaculatus. Of the constituent proteins in Lp, we focused on apolipophorin-III (GrybiApoLp-III) because of its possible role in facilitating lipid mobilization. First, we used RNAi to reduce the expression of GrybiApoLp-III. RNAi-mediated knockdown of GrybiApoLp-III had little effect on basal hemolymph lipid levels and the amount of food intake. In addition, hemolymph lipid levels remained static even after injecting AKH into GrybiApoLp-IIIRNAi crickets. These observations indicated that ApoLp-III does not maintain basal hemolymph lipid levels in crickets fed ad libitum, but is necessary for mobilizing lipid transfer into the hemolymph following AKH stimulation. Second, Lp (containing lipids) was injected into the hemolymph to induce a temporary increase in hemolymph lipid levels. Consequently, the initiation of feeding was delayed in a dose-dependent manner, indicating that increased hemolymph lipid levels reduced the motivation to feed. Taken together, these data validate the importance of basal hemolymph lipid levels in the control of energy homeostasis and for regulating feeding behavior in crickets. PMID:27144650

  13. Plasma membrane lipid-protein interactions affect signaling processes in sterol-biosynthesis mutants of Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Henrik eZauber

    2014-03-01

    Full Text Available The plasma membrane is an important organelle providing structure, signaling and transport as major biological functions. Being composed of lipids and proteins with different physicochemical properties, the biological functions of membranes depend on specific protein-protein and protein-lipid interactions. Interactions of proteins with their specific sterol and lipid environment were shown to be important factors for protein recruitment into sub-compartmental structures of the plasma membrane. System-wide implications of altered endogenous sterol levels for membrane functions in living cells were not studied in higher plant cells. In particular, little is known how alterations in membrane sterol composition affect protein and lipid organization and interaction within membranes. Here, we conducted a comparative analysis of the plasma membrane protein and lipid composition in Arabidopsis sterol-biosynthesis mutants smt1 and ugt80A2;B1. smt1 shows general alterations in sterol composition while ugt80A2;B1 is significantly impaired in sterol glycosylation. By systematically analyzing different cellular fractions and combining proteomic with lipidomic data we were able to reveal contrasting alterations in lipid-protein interactions in both mutants, with resulting differential changes in plasma membrane signaling status.

  14. Higher endogenous methionine in transgenic Arabidopsis seeds affects the composition of storage proteins and lipids.

    Science.gov (United States)

    Cohen, Hagai; Pajak, Agnieszka; Pandurangan, Sudhakar; Amir, Rachel; Marsolais, Frédéric

    2016-06-01

    Previous in vitro studies demonstrate that exogenous application of the sulfur-containing amino acid methionine into cultured soybean cotyledons and seedlings reduces the level of methionine-poor storage proteins and elevates those that are methionine-rich. However, the effect of higher endogenous methionine in seeds on the composition of storage products in vivo is not studied yet. We have recently produced transgenic Arabidopsis seeds having significantly higher levels of methionine. In the present work we used these seeds as a model system and profiled them for changes in the abundances of 12S-globulins and 2S-albumins, the two major groups of storage proteins, using 2D-gels and MALDI-MS detection. The findings suggest that higher methionine affects from a certain threshold the accumulation of several subunits of 12S-globulins and 2S-albumins, regardless of their methionine contents, resulting in higher total protein contents. The mRNA abundances of most of the genes encoding these proteins were either correlated or not correlated with the abundances of these proteins, implying that methionine may regulate storage proteins at both transcriptional and post-transcriptional levels. The elevations in total protein contents resulted in reduction of total lipids and altered the fatty acid composition. Altogether, the data provide new insights into the regulatory roles of elevated methionine levels on seed composition. PMID:26888094

  15. Lipid hydrolysis products affect the composition of infant gut microbial communities in vitro

    DEFF Research Database (Denmark)

    Bennike, Rikke Mette Guldhammer; Bahl, Martin Iain; Vigsnæs, Louise Kristine;

    2015-01-01

    14 : 0 and MAG 12 : 0) or long-chained NEFA (LC-NEFA; 16 : 0 to 18 : 1 and MAG 16 : 0) with and without sphingosine, representing lipid hydrolysis products characteristic for intestinal hydrolysis of breast milk lipids. Ion Torrent sequencing of the bacterial 16S ribosomal RNA gene revealed that the...

  16. Lipid emulsions differentially affect LPS-induced acute monocytes inflammation: in vitro effects on membrane remodeling and cell viability.

    Science.gov (United States)

    Boisramé-Helms, Julie; Delabranche, Xavier; Klymchenko, Andrey; Drai, Jocelyne; Blond, Emilie; Zobairi, Fatiha; Mely, Yves; Hasselmann, Michel; Toti, Florence; Meziani, Ferhat

    2014-11-01

    The aim of this study was to assess how lipid emulsions for parenteral nutrition affect lipopolysaccharide (LPS)-induced acute monocyte inflammation in vitro. An 18 h long LPS induced human monocyte leukemia cell stimulation was performed and the cell-growth medium was supplemented with three different industrial lipid emulsions: Intralipid(®), containing long-chain triglycerides (LCT--soybean oil); Medialipid(®), containing LCT (soybean oil) and medium-chain triglycerides (MCT--coconut oil); and SMOFlipid(®), containing LCT, MCT, omega-9 and -3 (soybean, coconut, olive and fish oils). Cell viability and apoptosis were assessed by Trypan blue exclusion and flow cytometry respectively. Monocyte composition and membrane remodeling were studied using gas chromatography and NR12S staining. Microparticles released in supernatant were measured by prothrombinase assay. After LPS challenge, both cellular necrosis and apoptosis were increased (threefold and twofold respectively) and microparticle release was enhanced (sevenfold) after supplementation with Medialipid(®) compared to Intralipid(®), SMOFlipid(®) and monocytes in the standard medium. The monocytes differentially incorporated fatty acids after lipid emulsion challenge. Finally, lipid-treated cells displayed microparticles characterized by disrupted membrane lipid order, reflecting lipid remodeling of the parental cell plasma membrane. Our data suggest that lipid emulsions differentially alter cell viability, monocyte composition and thereby microparticle release. While MCT have deleterious effects, we have shown that parenteral nutrition emulsion containing LCT or LCT and MCT associated to n-3 and n-9 fatty acids have no effect on endotoxin-induced cell death and inflammation. PMID:25038627

  17. Sex Hormones Affect Aging Process by Influencing Lipid Profiles,Cellular Immunological Function and Lipid Peroxides and Oxidation System

    Institute of Scientific and Technical Information of China (English)

    吴赛珠; 谭家余; 周忠江; 周可祥; 容志毅

    2003-01-01

    Objectives To investigate the correlation between sex hormones(SH) and aging. Methods Through epidemiological investigation in our country, the levels of SH were measured by radioimmunoassy; lipid profile, glucose and apolipoprotein by automatic biochemic analytical instrument; T cell subsets by flow cytometer; and MDA, SOD were evaluated by the thiobarbituric acid (TBA) test and the nitrite method modified by Oyanagui respectively using spectrophotometry. Results In men, the serum levels of follicle stimulating hormone (FSH)、 luteinizing hormone(LH) increased significantly with aging, but serum prolactin(PRL) and progesterone(P) levels remained unchanged in all life; Both testosterone (T)and free testosterone (FT) all decreased greatly with aging, but 173 - estradiol( 17β - E2) was reverse; E2 was negatively correlated with T and E2/T increased with aging. The level of serum total cholesterol (TC) increased with aging, but triglycerides ( TG ) remain unchanged; compared with young group, high -density lipoprotein cholesterol (HDL - C); HDL - C/TC of other groups decreased significantly, but low - density lipoprotein cholesterol ( LDL - C ) changed inversely;HDL- C/LDL- C reduced slightly with aging and showed no difference between groups. Apolipoprotein A1 (apoA1) and apoB all enhanced greatly with aging;meanwhile the ratio of apoAl/apoB decreased. The concentration of serum glucose (GLU) was unchanged in all life. To compare with those in the young group,CD3 + , CD4 + in other groups reduced greatly, CD4 + remained unchanged. Meanwhile, CD8 + increased significantly with aging. Compared with the young group, serum malondialdehyde(MDA) value of the old ones increased obviously, but the activity of superoxide dismutase(SOD) was reverse. By partial correlation analysis (controlling BMI, FSH, LH and PRL), TC、LDL- C、apoA1 、apoB、CD8 + 、MDA of men all presented a positive correlation with E2/T respectively,their correlation coefficients (γ) were 0.262、0

  18. Phenolic Lipids Affect the Activity and Conformation of Acetylcholinesterase from Electrophorus electricus (Electric eel)

    OpenAIRE

    Maria Stasiuk; Alicja Janiszewska; Arkadiusz Kozubek

    2014-01-01

    Phenolic lipids were isolated from rye grains, cashew nutshell liquid (CNSL) from Anacardium occidentale, and fruit bodies of Merrulius tremellosus, and their effects on the electric eel acetylcholinesterase activity and conformation were studied. The observed effect distinctly depended on the chemical structure of the phenolic lipids that were available for interaction with the enzyme. All of the tested compounds reduced the activity of acetylcholinesterase. The degree of inhibition varied, ...

  19. Insulin Resistance and Obesity Affect Lipid Profile in the Salivary Glands

    Science.gov (United States)

    Matczuk, Jan; Zalewska, Anna; Łukaszuk, Bartłomiej; Knaś, Małgorzata; Maciejczyk, Mateusz; Garbowska, Marta; Ziembicka, Dominika M.; Waszkiel, Danuta; Chabowski, Adrian; Żendzian-Piotrowska, Małgorzata

    2016-01-01

    In today's world wrong nutritional habits together with a low level of physical activity have given rise to the development of obesity and its comorbidity, insulin resistance. More specifically, many researches indicate that lipids are vitally involved in the onset of a peripheral tissue (e.g., skeletal muscle, heart, and liver) insulin resistance. Moreover, it seems that diabetes can also induce changes in respect of lipid composition of both the salivary glands and saliva. However, judging by the number of research articles, the salivary glands lipid profile still has not been sufficiently explored. In the current study we aim to assess the changes in the main lipid fractions, namely, triacylglycerols, phospholipids, free fatty acids, and diacylglycerols, in the parotid and the submandibular salivary glands of rats exposed to a 5-week high fat diet regimen. We observed that the high caloric fat diet caused a significant change in the salivary glands lipid composition, especially with respect to PH and TG, but not DAG or FFAs, classes. The observed reduction in PH concentration is an interesting phenomenon frequently signifying the atrophy and malfunctions in the saliva secreting organs. On the other hand, the increased accumulation of TG in the glands may be an important clinical manifestation of metabolic syndrome and type 2 diabetes mellitus. PMID:27471733

  20. Insulin Resistance and Obesity Affect Lipid Profile in the Salivary Glands

    Directory of Open Access Journals (Sweden)

    Jan Matczuk

    2016-01-01

    Full Text Available In today’s world wrong nutritional habits together with a low level of physical activity have given rise to the development of obesity and its comorbidity, insulin resistance. More specifically, many researches indicate that lipids are vitally involved in the onset of a peripheral tissue (e.g., skeletal muscle, heart, and liver insulin resistance. Moreover, it seems that diabetes can also induce changes in respect of lipid composition of both the salivary glands and saliva. However, judging by the number of research articles, the salivary glands lipid profile still has not been sufficiently explored. In the current study we aim to assess the changes in the main lipid fractions, namely, triacylglycerols, phospholipids, free fatty acids, and diacylglycerols, in the parotid and the submandibular salivary glands of rats exposed to a 5-week high fat diet regimen. We observed that the high caloric fat diet caused a significant change in the salivary glands lipid composition, especially with respect to PH and TG, but not DAG or FFAs, classes. The observed reduction in PH concentration is an interesting phenomenon frequently signifying the atrophy and malfunctions in the saliva secreting organs. On the other hand, the increased accumulation of TG in the glands may be an important clinical manifestation of metabolic syndrome and type 2 diabetes mellitus.

  1. Melatonin affects the order, dynamics and hydration of brain membrane lipids

    Science.gov (United States)

    Akkas, Sara B.; Inci, Servet; Zorlu, Faruk; Severcan, Feride

    2007-05-01

    The brain is especially susceptible to free radical attack since it is rich in polyunsaturated fatty acids and consumes very high amounts of oxygen. Melatonin is a non-enzymatic amphiphilic antioxidant hormone that is widely used in medicine for protective and treatment purposes in cases of oxidative stress. In the present work, the effects of the clinically used dose of melatonin (a single intraperitoneal dose of 100 mg/kg) on rat brain homogenate were investigated as a function of temperature using Fourier transform infrared spectroscopy. The results showed that the lipid to protein ratio decreases in the melatonin treated brain samples. Moreover, it is revealed that melatonin disorders and decreases the dynamics of lipids and induces a strengthening in the hydrogen bonding between the functional groups of both melatonin and the polar parts of lipids and/or water at physiological temperatures.

  2. Fish oil affects blood pressure and the plasma lipid profile in healthy Danish infants

    DEFF Research Database (Denmark)

    Damsgaard, C.T.; Schack-Nielsen, L.; Michaelsen, K.F.; Fruekilde, Maj-Britt; Hels, O.; Lauritzen, L.

    2006-01-01

    Animal and epidemiologic studies indicate that early nutrition has lasting effects on metabolism and cardiovascular disease risk. In adults, (n-3) long-chain PUFA (LCPUFA) from fish oils improve blood pressure, the lipid profile, and possibly cardiovascular disease mortality. This randomized trial...... is the first to investigate the effects of fish oil on blood pressure and the lipid profile in infancy. Healthy term 9-mo old infants In 83) were randomly assigned to 5 mL fish oil daily or no fish oil for 3 mo and to 2 different milk types. Before and after the intervention, blood pressure was...... measured with an oscillometric device, and blood was sampled for analysis of erythrocyte fatty acid composition and the plasma lipid profile. This paper examines the effects of the fish oil supplement, with adjustment for the effects of the milk intervention when relevant. The fish oil intervention...

  3. Dietary vitamin E affects lipid oxidation and total volatiles of irradiated raw turkey meat

    International Nuclear Information System (INIS)

    Breast and leg meat patties, prepared from turkeys fed diets containing 25, 200, 400 or 600 IU of dl-alpha-tocopheryl acetate (TA) per kg diet, were irradiated at 0 or 2.5 kGy with vacuum or loose packaging. The effects of dietary TA on storage stability and production of volatiles in irradiated raw turkey meat were determined. Dietary TA at 200 IU/kg decreased lipid oxidation and reduced total volatiles of raw turkey patties after 7-days of storage. However, the antioxidant effects of dietary TA were more notable when the patties were loosely packaged than when vacuum-packaged. Irradiation increased lipid oxidation of raw turkey meats only when loosely packaged but had limited effects on formation of total volatiles after storage at 4 degrees C for 7 days or longer

  4. The hydroperoxide moiety of aliphatic lipid hydroperoxides is not affected by hypochlorous acid

    OpenAIRE

    Zschaler, Josefin; Arnhold, Jürgen

    2015-01-01

    The oxidation of polyunsaturated fatty acids to the corresponding hydroperoxide by plant and animal lipoxygenases is an important step for the generation of bioactive lipid mediators. Thereby fatty acid hydroperoxide represent a common intermediate, also in human innate immune cells, like neutrophil granulocytes. In these cells a further key component is the heme protein myeloperoxidase producing HOCl as a reactive oxidant. On the basis of different investigation a reaction of the fatty ac...

  5. Affected by abundant PLTP : the atherogenic role of a lipid transfer protein in transgenic mice

    OpenAIRE

    Samyn, Hannelore; Moerland, Matthijs

    2009-01-01

    markdownabstract__Abstract__ Atherosclerosis is a progressive disease of the large and medium-sized arteries. The disease is characterised by endothelial dysfunction, inflammation and the accumulation of fatty and fibrous substances in the vessel wall, resulting in thickening and loss of elasticity of the arteries. The word atherosclerosis has been derived from the Greek words "athera", porridge or gruel, and "skleros", hard or stiff. These words describe the external features of the lipid-lo...

  6. Cocoa and Whey Protein Differentially Affect Markers of Lipid and Glucose Metabolism and Satiety.

    Science.gov (United States)

    Campbell, Caroline L; Foegeding, E Allen; Harris, G Keith

    2016-03-01

    Food formulation with bioactive ingredients is a potential strategy to promote satiety and weight management. Whey proteins are high in leucine and are shown to decrease hunger ratings and increase satiety hormone levels; cocoa polyphenolics moderate glucose levels and slow digestion. This study examined the effects of cocoa and whey proteins on lipid and glucose metabolism and satiety in vitro and in a clinical trial. In vitro, 3T3-L1 preadipocytes were treated with 0.5-100 μg/mL cocoa polyphenolic extract (CPE) and/or 1-15 mM leucine (Leu) and assayed for lipid accumulation and leptin production. In vivo, a 6-week clinical trial consisted of nine panelists (age: 22.6 ± 1.7; BMI: 22.3 ± 2.1) consuming chocolate-protein beverages once per week, including placebo, whey protein isolate (WPI), low polyphenolic cocoa (LP), high polyphenolic cocoa (HP), LP-WPI, and HP-WPI. Measurements included blood glucose and adiponectin levels, and hunger ratings at baseline and 0.5-4.0 h following beverage consumption. At levels of 50 and 100 μg/mL, CPE significantly inhibited preadipocyte lipid accumulation by 35% and 50%, respectively, and by 22% and 36% when combined with 15 mM Leu. Leu treatment increased adipocyte leptin production by 26-37%. In the clinical trial, all beverages significantly moderated blood glucose levels 30 min postconsumption. WPI beverages elicited lowest peak glucose levels and HP levels were significantly lower than LP. The WPI and HP beverage treatments significantly increased adiponectin levels, but elicited no significant changes in hunger ratings. These trends suggest that combinations of WPI and cocoa polyphenols may improve markers of metabolic syndrome and satiety. PMID:26987021

  7. Kiwifruit consumption favourably affects plasma lipids in a randomised controlled trial in hypercholesterolaemic men.

    Science.gov (United States)

    Gammon, Cheryl S; Kruger, Rozanne; Minihane, Anne M; Conlon, Cathryn A; von Hurst, Pamela R; Stonehouse, Welma

    2013-06-28

    The unique composition of green kiwifruit has the potential to benefit CVD risk. The aim of the present study was to investigate the effect of consuming two green kiwifruits daily in conjunction with a healthy diet on plasma lipids and other metabolic markers and to examine response according to APOE genotype in hypercholesterolaemic men. After undergoing a 4-week healthy diet, eighty-five hypercholesterolaemic men (LDL-cholesterol (LDL-C) > 3.0 mmol/l and TAG < 3 mmol/l) completed an 8-week randomised controlled cross-over study of two 4-week intervention sequences of two green kiwifruits per d plus healthy diet (intervention) or healthy diet alone (control). Anthropometric measures, blood pressure (BP) and fasting blood samples (plasma lipids, serum apoA1 and apoB, insulin, glucose, high-sensitivity C-reactive protein (hs-CRP)) were taken at baseline, and at 4 and 8 weeks. After the kiwifruit intervention, plasma HDL-cholesterol (HDL-C) concentrations were significantly higher (mean difference 0.04; 95% CI 0.01, 0.07 mmol/l; P = 0.004) and the total cholesterol (TC):HDL-C ratio was significantly lower (mean difference 20.5; 95% CI 20.24, 20.05 mmol/l; P = 0.002) compared with the control. In carriers of the APOE4 allele, TAG decreased significantly (mean difference -0.18; 95% CI -0.34, -0.02 mol/l; P = 0.03) with kiwifruit compared with control. There were no significant differences between the two interventions for plasma TC, LDL-C, insulin, glucose, hs-CRP and BP. The small but significant increase in HDL-C and decrease in TC:HDL-C ratio and TAG (in APOE4 carriers) suggest that the regular inclusion of green kiwifruit as part of a healthy diet may be beneficial in improving the lipid profiles of men with high cholesterol. PMID:23151354

  8. Dietary conjugated linoleic acids affect tissue lipid composition but not de novo lipogenesis in finishing pigs

    OpenAIRE

    Bee, Giuseppe

    2001-01-01

    Influence de l'apport des acides linoléiques conjugués dans l'alimentation sur la composition des tissus adipeux et la lipogenèse de novo chez les porcs en finition. Plusieurs travaux ont révélé que les acides linoléiques conjugués (conjugated linoleic acids : CLA) ont une influence importante sur le métabolisme des lipides et des protéines. En revanche, les effets des CLA sur le profil des acides gras dans les tissus adipeux chez le porc sont peu connus. Dans cette étude, nous avons détermin...

  9. A review of nutritional and physiological factors affecting goat milk lipid synthesis and lipolysis.

    Science.gov (United States)

    Chilliard, Y; Ferlay, A; Rouel, J; Lamberet, G

    2003-05-01

    Although the effect of lactation stage is similar, the responses of milk yield and composition (fat and protein contents) to different types of lipid supplements differ greatly between goats and cows. Milk fat content increases with almost all studied fat supplements in goats but not in cows. However, the response of milk fatty acid (FA) composition is similar, at least for major FA, including conjugated linoleic acid (CLA) in goats and cows supplemented with either protected or unprotected lipid supplements. Goat milk CLA content increases sharply after either vegetable oil supplementation or fresh grass feeding, but does not change markedly when goats receive whole untreated oilseeds. Important interactions are observed between the nature of forages and of oil supplements on trans-10 and trans-11 C18:1 and CLA. Peculiarities of goat milk FA composition and lipolytic system play an important role in the development of either goat flavor (release of branched, medium-chain FA) or rancidity (excessive release of butyric acid). The lipoprotein lipase (LPL) activity, although lower in goat than in cow milk, is more bound to the fat globules and better correlated to spontaneous lipolysis in goat milk. The regulation of spontaneous lipolysis differs widely between goats and cows. Goat milk lipolysis and LPL activity vary considerably and in parallel across goat breeds or genotypes, and are low during early and late lactation, as well as when animals are underfed or receive a diet supplemented with protected or unprotected vegetable oils. This could contribute to decreases in the specific flavor of goat dairy products with diets rich in fat. PMID:12778586

  10. Carry-over effects and compensation: late arrival on non-breeding grounds affects wing moult but not plumage or schedules of departing bar-tailed godwits Limosa lapponica baueri

    NARCIS (Netherlands)

    Conklin, Jesse R.; Battley, Phil F.

    2012-01-01

    In the annual cycle of migratory birds, temporal and energetic constraints can lead to carry-over effects, in which performance in one life history stage affects later stages. Bar-tailed godwits Limosa lapponica baueri, which achieve remarkably high pre-migratory fuel loads, undertake the longest no

  11. Supplemental barley protein and casein similarly affect serum lipids in hypercholesterolemic women and men.

    Science.gov (United States)

    Jenkins, David J A; Srichaikul, Korbua; Wong, Julia M W; Kendall, Cyril W C; Bashyam, Balachandran; Vidgen, Edward; Lamarche, Benoicirct; Rao, A Venketeshwer; Jones, Peter J H; Josse, Robert G; Jackson, Chung-Ja C; Ng, Vivian; Leong, Tracy; Leiter, Lawrence A

    2010-09-01

    High-protein diets have been advocated for weight loss and the treatment of diabetes. Yet animal protein sources are often high in saturated fat and cholesterol. Vegetable protein sources, by contrast, are low in saturated fat and without associated cholesterol. We have therefore assessed the effect on serum lipids of raising the protein intake by 5% using a cereal protein, barley protein, as part of a standard therapeutic diet. Twenty-three hypercholesterolemic men and postmenopausal women completed a randomized crossover study comparing a bread enriched with either barley protein or calcium caseinate [30 g protein, 8374 kJ (2000 kcal)] taken separately as two 1-mo treatment phases with a minimum 2-wk washout. Body weight and diet history were collected weekly during each treatment. Fasting blood samples were obtained at wk 0, 2, and 4. Palatability, satiety, and compliance were similar for both the barley protein- and casein-enriched breads, with no differences between the treatments in effects on serum LDL cholesterol or C-reactive protein, measures of oxidative stress, or blood pressure. Nevertheless, because no adverse effects were observed on cardiovascular risk factors, barley protein remains an additional option for raising the protein content of the diet. PMID:20668250

  12. Calcium and protons affect the interaction of neurotransmitters and anesthetics with anionic lipid membranes.

    Science.gov (United States)

    Pérez-Isidoro, Rosendo; Ruiz-Suárez, J C

    2016-09-01

    We study how zwitterionic and anionic biomembrane models interact with neurotransmitters (NTs) and anesthetics (ATs) in the presence of Ca(2+) and different pH conditions. As NTs we used acetylcholine (ACh), γ-aminobutyric acid (GABA), and l-glutamic acid (LGlu). As ATs, tetracaine (TC), and pentobarbital (PB) were employed. By using differential scanning calorimetry (DSC), we analyzed the changes such molecules produce in the thermal properties of the membranes. We found that calcium and pH play important roles in the interactions of NTs and ATs with the anionic lipid membranes. Changes in pH promote deprotonation of the phosphate groups in anionic phospholipids inducing electrostatic interactions between them and NTs; but if Ca(2+) ions are in the system, these act as bridges. Such interactions impact the physical properties of the membranes in a similar manner that anesthetics do. Beyond the usual biochemical approach, we claim that these effects should be taken into account to understand the excitatory-inhibitory orchestrated balance in the nervous system. PMID:27362370

  13. Cholesterol strongly affects the organization of lipid monolayers studied as models of the milk fat globule membrane: Condensing effect and change in the lipid domain morphology.

    Science.gov (United States)

    Murthy, Appala Venkata Ramana; Guyomarc'h, Fanny; Paboeuf, Gilles; Vié, Véronique; Lopez, Christelle

    2015-10-01

    The biological membrane that surrounds the milk fat globules exhibits phase separation of polar lipids that is poorly known. The objective of this study was to investigate the role played by cholesterol in the organization of monolayers prepared as models of the milk fat globule membrane (MFGM). Differential scanning calorimetry and X-ray diffraction experiments allowed characterization of the gel to liquid crystalline phase transition temperature of lipids, Tm ~35°C, in vesicles prepared with a MFGM lipid extract. For temperature below Tm, atomic force microscopy revealed phase separation of lipids at 30 mN·m(-1) in Langmuir-Blodgett monolayers of the MFGM lipid extract. The high Tm lipids form liquid condensed (LC) domains that protrude by about 1.5 nm from the continuous liquid expanded (LE) phase. Cholesterol was added to the MFGM extract up to 30% of polar lipids (cholesterol/milk sphingomyelin (MSM) molar ratio of 50/50). Compression isotherms evidenced the condensing effect of the cholesterol onto the MFGM lipid monolayers. Topography of the monolayers showed a decrease in the area of the LC domains and in the height difference H between the LC domains and the continuous LE phase, as the cholesterol content increased in the MFGM lipid monolayers. These results were interpreted in terms of nucleation effects of cholesterol and decrease of the line tension between LC domains and LE phase in the MFGM lipid monolayers. This study revealed the major structural role of cholesterol in the MFGM that could be involved in biological functions of this interface (e.g. mechanisms of milk fat globule digestion). PMID:26087463

  14. Apolipoprotein M affecting lipid metabolism or just catching a ride with lipoproteins in the circulation?

    DEFF Research Database (Denmark)

    Dahlbäck, B; Nielsen, Lars Bo

    2009-01-01

    link to cholesterol metabolism. However, in casecontrol studies, apoM levels in patients with coronary heart disease (CHD) and controls were similar, suggesting apoM levels not to affect the risk for CHD in humans. Experiments in transgenic mice suggested apoM to have antiatherogenic properties......; possible mechanisms include increased formation of pre-ss HDL, enhanced cholesterol mobilization from foam cells, and increased antioxidant properties....

  15. Peripheral vagus nerve stimulation significantly affects lipid composition and protein secondary structure within dopamine-related brain regions in rats.

    Science.gov (United States)

    Surowka, Artur Dawid; Krygowska-Wajs, Anna; Ziomber, Agata; Thor, Piotr; Chrobak, Adrian Andrzej; Szczerbowska-Boruchowska, Magdalena

    2015-06-01

    Recent immunohistochemical studies point to the dorsal motor nucleus of the vagus nerve as the point of departure of initial changes which are related to the gradual pathological developments in the dopaminergic system. In the light of current investigations, it is likely that biochemical changes within the peripheral nervous system may influence the physiology of the dopaminergic system, suggesting a putative role for it in the development of neurodegenerative disorders. By using Fourier transform infrared microspectroscopy, coupled with statistical analysis, we examined the effect of chronic, unilateral electrical vagus nerve stimulation on changes in lipid composition and in protein secondary structure within dopamine-related brain structures in rats. It was found that the chronic vagal nerve stimulation strongly affects the chain length of fatty acids within the ventral tegmental area, nucleus accumbens, substantia nigra, striatum, dorsal motor nucleus of vagus and the motor cortex. In particular, the level of lipid unsaturation was found significantly increasing in the ventral tegmental area, substantia nigra and motor cortex as a result of vagal nerve stimulation. When it comes to changes in protein secondary structure, we could see that the mesolimbic, mesocortical and nigrostriatal dopaminergic pathways are particularly affected by vagus nerve stimulation. This is due to the co-occurrence of statistically significant changes in the content of non-ordered structure components, alpha helices, beta sheets, and the total area of Amide I. Macromolecular changes caused by peripheral vagus nerve stimulation may highlight a potential connection between the gastrointestinal system and the central nervous system in rat during the development of neurodegenerative disorders. PMID:25893743

  16. Sitamaquine-resistance in Leishmania donovani affects drug accumulation and lipid metabolism.

    Science.gov (United States)

    Imbert, L; Cojean, S; Libong, D; Chaminade, P; Loiseau, P M

    2014-09-01

    This study focuses on the mechanism of sitamaquine-resistance in Leishmania donovani. Sitamaquine accumulated 10 and 1.4 fold more in cytosol than in membranes of wild-type (WT) and of sitamaquine-resistant (Sita-R160) L. donovani promastigotes, respectively. The sitamaquine accumulation was a concentration-dependent process in WT whereas a saturation occurred in Sita-R160 suggesting a reduced uptake or an increase of the sitamaquine efflux. Membrane negative phospholipids being the main target for sitamaquine uptake, a lipidomic analysis showed that sitamaquine-resistance did not rely on a decrease of membrane negative phospholipid rate in Sita-R160, discarding the hypothesis of reduced uptake. However, sterol and phospholipid metabolisms were strongly affected in Sita-R160 suggesting that sitamaquine-resistance could be related to an alteration of phosphatidylethanolamine-N-methyl-transferase and choline kinase activities and to a decrease in cholesterol uptake and of ergosterol biosynthesis. Preliminary data of proteomics analysis exhibited different protein profiles between WT and Sita-160R remaining to be characterized. PMID:25201056

  17. Social Organization in Bars: Implications for Tobacco Control Policy

    OpenAIRE

    Lee, Juliet P.; Antin, Tamar M.J.; Roland S. Moore

    2008-01-01

    This paper considers social roles and relationships of the patrons, staff and owners of bars as critical factors determining adherence to public health policies, and specifically California’s smokefree workplace law. Specific elements of social organization in bars affecting health policy include the community within which the bar is set, the unique identity the bar creates, the bar staff and patrons who enact this identity, and their bar society. These elements were found to contribute to th...

  18. Embryonic exposures of lithium and homocysteine and folate protection affect lipid metabolism during mouse cardiogenesis and placentation.

    Science.gov (United States)

    Han, Mingda; Evsikov, Alexei V; Zhang, Lifeng; Lastra-Vicente, Rosana; Linask, Kersti K

    2016-06-01

    Embryonic exposures can increase the risk of congenital cardiac birth defects and adult disease. The present study identifies the predominant pathways modulated by an acute embryonic mouse exposure during gastrulation to lithium or homocysteine that induces cardiac defects. High dose periconceptional folate supplementation normalized development. Microarray bioinformatic analysis of gene expression demonstrated that primarily lipid metabolism is altered after the acute exposures. The lipid-related modulation demonstrated a gender bias with male embryos showing greater number of lipid-related Gene Ontology biological processes altered than in female embryos. RT-PCR analysis demonstrated significant change of the fatty acid oxidation gene Acadm with homocysteine exposure primarily in male embryos than in female. The perturbations resulting from the exposures resulted in growth-restricted placentas with disorganized cellular lipid droplet distribution indicating lipids have a critical role in cardiac-placental abnormal development. High folate supplementation protected normal heart-placental function, gene expression and lipid localization. PMID:26993217

  19. Parenteral lipids and partial enteral nutrition affect hepatic lipid composition but have limited short term effects on formula-induced necrotizing enterocolitis in preterm piglets

    DEFF Research Database (Denmark)

    Vegge, Andreas; Thymann, Thomas; Lauritzen, Lotte;

    2015-01-01

    Rapid transition from total parenteral nutrition (TPN) to enteral feeding is a risk factor for necrotizing enterocolitis (NEC) in preterm infants. We hypothesized that partial enteral nutrition with colostrum, increased proportion of n-3 polyunsaturated fatty acids (PUFA), or exclusion of lipid i...

  20. SCREENING OF SELECTED OLEAGINOUS YEASTS FOR LIPID PRODUCTION FROM GLYCEROL AND SOME FACTORS WHICH AFFECT LIPID PRODUCTION BY YARROWIA LIPOLYTICA STRAINS

    Directory of Open Access Journals (Sweden)

    Salinee Sriwongchai

    2013-04-01

    Full Text Available The ability of eight yeast strains to utilize glycerol as a sole carbon source and accumulate lipids in a chemically defined medium was screened. Among the yeasts, Yarrowia lipolytica strains DSM 70561 and JDC 335 grew to high cell densities on glycerol. These strains were further tested for lipid accumulation under varying nutritional conditions in Erlenmeyer flasks. The results showed that strains DSM 70561 and JDC 335 accumulated lipids up to 37.1 % and 54.4 % of total cell dry weight, respectively, when the defined medium was supplemented with 1 g/L urea and 2 g/L yeast extract. The lipids accumulated by the two yeasts contained a high proportion of C16:0, C18:1, C18:2 and C18:0 fatty acids. The results suggest that Y. lipolytica strains DSM 70561 and JDC 335 have the potential for converting crude glycerol into fatty acids which can in turn be utilized as substrate for biodiesel production.

  1. Does high offshore petroleum activity affect the lipid composition in wild Atlantic Cod (Gadus morhua) from the North Sea?

    OpenAIRE

    Liu, Li

    2012-01-01

    A combined two step extraction, using hexane/methanol to extract neutral lipids and chloroform/methanol to extract polar lipids, has been developed and validation. Four times methanol wash were done to hexane/methanol extract and merged with chloroform/methanol extract to ensure optimized lipid classes distribution between two solvent systems. Quick freeze of hexane/methanol solvent system by dry ice was adopted to avoid adverse effect of generation of micelle. The glass aminopropyl bonded co...

  2. How the multiple antioxidant properties of ascorbic acid affect lipid oxidation in oil-in-water emulsions.

    Science.gov (United States)

    Uluata, Sibel; McClements, D Julian; Decker, Eric A

    2015-02-18

    Lipid oxidation is a serious problem for oil-containing food products because it negatively affects shelf life and nutritional composition. An antioxidant strategy commonly employed to prevent or delay oxidation in foods is to remove oxygen from the closed food-packaging system. An alternative technique is use of an edible oxygen scavenger to remove oxygen within the food. Ascorbic acid (AA) is a particularly promising antioxidant because of its natural label and multiple antioxidative functions. In this study, AA was tested as an oxygen scavenger in buffer and an oil-in-water (O/W) emulsion. The effects of transition metals on the ability of AA to scavenge oxygen were determined. Headspace oxygen decrease less than 1% in the medium-chain triacylglycerol (MCT) O/W emulsion system (pH 3 and 7). AA was able to almost completely remove dissolved oxygen (DO) in a buffered solution. Transition metals (Fe(2+) and Cu(+)) significantly accelerated the degradation of AA; however, iron and copper only increased DO depletion rates, by 10.6-16.4% from day 1 to 7, compared to the control. AA (2.5-20 mM) decreased DO in a 1% O/W emulsion system 32.0-64.0% and delayed the formation of headspace hexanal in the emulsion from 7 to over 20 days. This research shows that, when AA is used in an O/W emulsion system, oxidation of the emulsion system can be delay by multiple mechanisms. PMID:25650525

  3. Too Much Bar and Not Enough Mitzvah? A Proposed Research Agenda on Bar/Bat Mitzvah

    Science.gov (United States)

    Schoenfeld, Stuart

    2010-01-01

    Jewish educators are understandably interested in research on how bar/bat mitzvah affect Jewish education or research on what Jewish schools have done to avoid the distortions of a focus on bar/bat mitzvah. Research might also focus on the somewhat different and more ambitious topic of the role that bar/bat mitzvah play in contemporary Jewish…

  4. Bar dimensions and bar shapes in estuaries

    Science.gov (United States)

    Leuven, Jasper; Kleinhans, Maarten; Weisscher, Steven; van der Vegt, Maarten

    2016-04-01

    Estuaries cause fascinating patterns of dynamic channels and shoals. Intertidal sandbars are valuable habitats, whilst channels provide access to harbors. We still lack a full explanation and classification scheme for the shapes and dimensions of bar patterns in natural estuaries, in contrast with bars in rivers. Analytical physics-based models suggest that bar length in estuaries increases with flow velocity, tidal excursion length or estuary width, depending on which model. However, these hypotheses were never validated for lack of data and experiments. We present a large dataset and determine the controls on bar shape and dimensions in estuaries, spanning bar lengths from centimeters (experiments) to 10s of kilometers length. First, we visually identified and classified 190 bars, measured their dimensions (width, length, height) and local braiding index. Data on estuarine geometry and tidal characteristics were obtained from governmental databases and literature on case studies. We found that many complex bars can be seen as simple elongated bars partly cut by mutually evasive ebb- and flood-dominated channels. Data analysis shows that bar dimensions scale with estuary dimensions, in particular estuary width. Breaking up the complex bars in simple bars greatly reduced scatter. Analytical bar theory overpredicts bar dimensions by an order of magnitude in case of small estuarine systems. Likewise, braiding index depends on local width-to-depth ratio, as was previously found for river systems. Our results suggest that estuary dimensions determine the order of magnitude of bar dimensions, while tidal characteristics modify this. We will continue to model bars numerically and experimentally. Our dataset on tidal bars enables future studies on the sedimentary architecture of geologically complex tidal deposits and enables studying effects of man-induced perturbations such as dredging and dumping on bar and channel patterns and habitats.

  5. Methylmalonic and propionic acidemias: lipid profiles of normal and affected human skin fibroblasts incubated with [1-14C]propionate

    International Nuclear Information System (INIS)

    Normal human skin fibroblasts and those from methylmalonic acidemia and propionic acidemia patients were grown in culture. Following incubation with [1-14C]propionate, the major lipid classes in the cells were separated by thin layer chromatography and isolated fractions analyzed by radio gas chromatography for the presence of odd-numbered long-chain fatty acids; the pattern of even-numbered long-chain fatty acids was obtained also. Normal fibroblasts incorporated a small percentage of propionate into odd-numbered fatty acids which were present in all lipids studied. The abnormal cells incorporated a larger amount while maintaining the characteristic ratios of odd-numbered fatty acids found in the normal line. Most of the radioactivity was associated with phospholipids which are the predominant constituents of cell membranes. A characteristic C15/C17 ratio was found for different phospholipids and the triglyceride fraction; pentadecanoic acid was the principal odd-numbered fatty acid utilized in the assembly of complex lipids. Compared to even-numbered long-chain fatty acids the absolute amount of odd-numbered fatty acids was low (1-2%), even in affected cells. An unusual polar lipid fraction was isolated in the course of the study. In the normal cell it contained several unlabeled eicosanoids which were missing from the same fraction of both affected cell lines

  6. Disruption of the lipid-transporting LdMT-LdRos3 complex in Leishmania donovani affects membrane lipid asymmetry but not host cell invasion.

    Directory of Open Access Journals (Sweden)

    Adrien Weingärtner

    Full Text Available Maintenance and regulation of the asymmetric lipid distribution across eukaryotic plasma membranes is governed by the concerted action of specific membrane proteins controlling lipid movement across the bilayer. Here, we show that the miltefosine transporter (LdMT, a member of the P4-ATPase subfamily in Leishmania donovani, and the Cdc50-like protein LdRos3 form a stable complex that plays an essential role in maintaining phospholipid asymmetry in the parasite plasma membrane. Loss of either LdMT or LdRos3 abolishes ATP-dependent transport of NBD-labelled phosphatidylethanolamine (PE and phosphatidylcholine from the outer to the inner plasma membrane leaflet and results in an increased cell surface exposure of endogenous PE. We also find that promastigotes of L. donovani lack any detectable amount of phosphatidylserine (PS but retain their infectivity in THP-1-derived macrophages. Likewise, infectivity was unchanged for parasites without LdMT-LdRos3 complexes. We conclude that exposure of PS and PE to the exoplasmic leaflet is not crucial for the infectivity of L. donovani promastigotes.

  7. Disruption of the lipid-transporting LdMT-LdRos3 complex in Leishmania donovani affects membrane lipid asymmetry but not host cell invasion.

    Science.gov (United States)

    Weingärtner, Adrien; Drobot, Björn; Herrmann, Andreas; Sánchez-Cañete, María P; Gamarro, Francisco; Castanys, Santiago; Günther Pomorski, Thomas

    2010-01-01

    Maintenance and regulation of the asymmetric lipid distribution across eukaryotic plasma membranes is governed by the concerted action of specific membrane proteins controlling lipid movement across the bilayer. Here, we show that the miltefosine transporter (LdMT), a member of the P4-ATPase subfamily in Leishmania donovani, and the Cdc50-like protein LdRos3 form a stable complex that plays an essential role in maintaining phospholipid asymmetry in the parasite plasma membrane. Loss of either LdMT or LdRos3 abolishes ATP-dependent transport of NBD-labelled phosphatidylethanolamine (PE) and phosphatidylcholine from the outer to the inner plasma membrane leaflet and results in an increased cell surface exposure of endogenous PE. We also find that promastigotes of L. donovani lack any detectable amount of phosphatidylserine (PS) but retain their infectivity in THP-1-derived macrophages. Likewise, infectivity was unchanged for parasites without LdMT-LdRos3 complexes. We conclude that exposure of PS and PE to the exoplasmic leaflet is not crucial for the infectivity of L. donovani promastigotes. PMID:20865154

  8. A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women

    DEFF Research Database (Denmark)

    Hallund, Jesper; Ravn-Haren, Gitte; Bügel, S.;

    2006-01-01

    A lignan complex rich in the plant lignan secoisolariciresinol diglucoside (SDG) was isolated from flaxseed. SDG is metabolized by the colonic microflora to the mammalian lignans enterodiol (END) and enterolactone (ENL), and was hypothesized to reduce plasma lipid concentrations and improve...... antioxidant capacity, The aim of this study was to investigate the effects of a lignan complex, providing 500 mg/d of SDG, on serum concentration and urinary excretion of ENL, plasma lipids, serum lipoprotein oxidation resistance, and markers of antioxidant capacity. Healthy postmenopausal women (n=22...

  9. Blurring in bar code signals

    Science.gov (United States)

    Tang, Hong

    1997-10-01

    When a bar code symbol is passed over a scanner, it is struck across by a fast moving laser beam. The laser light is scattered by the bar code. The total scattered power is modulated by the reflectivity of the bars and spaces in the symbol. A fraction of the scattered light is collected and focused onto a photodetector that converts the light variation into an electronic signal. The electronic signal is then digitized for analysis by a computer. The scanning and detection process can be modeled by a convolution of the laser beam profile and the bar code reflectivity function. The switching between states in the digitized bar code signal, which represents transitions from a space to a bar or vice versa, is determined by a zero-crossing point in the second derivative of the analog signal. The laser profile acts like a smoothing function. It blurs the analog electronic signal. If the width of the laser profile is less than the minimum width of bars and spaces in the bar code reflectivity function, the transition point is not affected by the location of its neighboring edges. If the laser profile is wider than the minimum width in the bar code, the transition point can be shifted due to the locations of its neighboring edges. The behavior of the shift of transition is analyzed here for all cases in a UPC symbol. It is found that the amount of shift in the transition point is almost the same for several different cases within the depth of field of the scanner. The knowledge of the behavior of transition point shift can be used to accurately compensate printing errors in an over-printed bar code. The modulation transfer function (MTF) of bar code scanning is the Fourier transform of the marginal function of the scanning laser beam. The MTF through focus for a scanning system is presented. By using an aperture with central obscuration in the laser focusing system, the high frequency resolution of bar code scanning can be enhanced and the depth of field of the scanner can

  10. JAK and STAT members of yellow catfish Pelteobagrus fulvidraco and their roles in leptin affecting lipid metabolism.

    Science.gov (United States)

    Wu, Kun; Tan, Xiao-Ying; Xu, Yi-Huan; Chen, Qi-Liang; Pan, Ya-Xiong

    2016-01-15

    The present study clones and characterizes the full-length cDNA sequences of members in JAK-STAT pathway, explores their mRNA tissue expression and the biological role in leptin influencing lipid metabolism in yellow catfish Pelteobagrus fulvidraco. Full-length cDNA sequences of five JAKs and seven STAT members, including some splicing variants, were obtained from yellow catfish. Compared to mammals, more members of the JAKs and STATs family were found in yellow catfish, which provided evidence that the JAK and STAT family members had arisen by the whole genome duplications during vertebrate evolution. All of these members were widely expressed across the eleven tissues (liver, white muscle, spleen, brain, gill, mesenteric fat, anterior intestine, heart, mid-kidney, testis and ovary) but at the variable levels. Intraperitoneal injection in vivo and incubation in vitro of recombinant human leptin changed triglyceride content and mRNA expression of several JAKs and STATs members, and genes involved in lipid metabolism. AG490, a specific inhibitor of JAK2-STAT pathway, partially reversed leptin-induced effects, indicating that the JAK2a/b-STAT3 pathway exerts main regulating actions of leptin on lipid metabolism at transcriptional level. Meanwhile, the different splicing variants were differentially regulated by leptin incubation. Thus, our data suggest that leptin activated the JAK/STAT pathway and increases the expression of target genes, which partially accounts for the leptin-induced changes in lipid metabolism in yellow catfish. PMID:26704851

  11. Lipid induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling

    DEFF Research Database (Denmark)

    Høeg, Louise D; Sjøberg, Kim Anker; Jeppesen, Jacob;

    2011-01-01

    (60%) after intralipid infusion. Hepatic glucose production was decreased during the clamp similarly in women and men irrespective of intralipid infusion. Intralipid did not impair insulin or AMPK signaling in muscle and subcutaneous fat, did not cause accumulation of muscle lipid intermediates...

  12. Lipid-based nutrient supplements do not affect efavirenz but lower plasma nevirapine concentrations in Ethiopian adult HIV patients

    DEFF Research Database (Denmark)

    Abdissa, A; Olsen, Mette Frahm; Yilma, D; Tesfaye, M; Girma, T; Christiansen, M; Hagen, C M; Wiesner, L; Castel, S; Aseffa, A; McIlleron, H; Pedersen, C; Friis, Henrik; Andersen, A B

    2015-01-01

    OBJECTIVES: Lipid-based nutrient supplements (LNSs) are increasingly used in HIV programmes in resource-limited settings. However, the possible effects of LNSs on the plasma concentrations of antiretroviral drugs have not been assessed. Here, we aimed to assess the effects of LNSs on plasma...

  13. Antifungal canthin-6-one series accumulate in lipid droplets and affect fatty acid metabolism in Saccharomyces cerevisiae

    OpenAIRE

    Lagoutte, D.; Nicolas, V; Poupon, E.; Fournet, Anne; Hocquemiller, R.; Libong, D.; Chaminade, P.; Loiseau, P.M.

    2008-01-01

    The mechanism of action of antifungal canthin-6-one series was investigated in Saccharomyces cerevisiae. After a rapid uptake, a preferential accumulation of the drug within lipid droplets was observed. The antifungal action of canthin-6-one was found as reversible. Canthin-6-one did not exhibit affinity for sterols, and membrane ergosterol was not necessary for the antifungal activity since the MICs were similar on an ergosterol-deleted and the wild-type S. cerevisiae clones. Relative amount...

  14. Hydrocortisone stimulates the development of oligodendrocytes in primary glial cultures and affects glucose metabolism and lipid synthesis in these cultures

    OpenAIRE

    Warringa, R.A.J.; Hoeben, R C; Koper, W.J.; Sykes, J.E.C.; Golde, L.M.G. van; Lopes-Cardozo, M.

    1987-01-01

    Cultures of glial cells were prepared from the brains of one-week-old rat pups. After one day in culture, serum was omitted from the medium and replaced by a combination of growth-stimulating hormones and other factors that enhanced the percentage of oligodendrocytes in the cultures. We investigated the effects of hydrocortisone on the development of oligodendrocytes, on the activities of oligodendrocyte-specific enzymes and on glucose- and lipid-metabolism of the glial cells. (1) Hydrocortis...

  15. Isolation and Expression Analysis of STAT Members from Synechogobius hasta and Their Roles in Leptin Affecting Lipid Metabolism

    Directory of Open Access Journals (Sweden)

    Kun Wu

    2016-03-01

    Full Text Available Signal transducers and activators of transcription proteins (STATs act as important mediators in multiple biological processes induced by a large number of cytokines. In the present study, full-length cDNA sequences of seven STAT members, including some splicing variants different from those in mammals, were obtained from Synechogobius hasta. The phylogenetic analysis revealed that the seven STAT members were derived from paralogous genes that might have arisen by whole genome duplication (WGD events during vertebrate evolution. All of these members share similar domain structure compared with those of mammals, and were widely expressed across the tested tissues (brain, gill, heart, intestine, liver, muscle and spleen, but at variable levels. Incubation in vitro of recombinant human leptin changed the intracellular triglyceride (TG content and mRNA levels of several STATs members, as well as expressions and activities of genes involved in lipid metabolism. Furthermore, Tyrphostin B42 (AG490, a specific inhibitor of the Janus Kinase 2(JAK2-STAT pathway, partially reversed leptin-induced change on STAT3 and its two spliced isoforms expression, as well as expressions and activities of genes involved in lipid metabolism. As a consequence, the decrease of TG content was also reversed. Thus, our study suggests that STAT3 is the requisite for the leptin signal and the activation of the STAT3 member may account for the leptin-induced changes in lipid metabolism in S. hasta.

  16. Ripened dairy products differentially affect hepatic lipid content and adipose tissue oxidative stress markers in obese and type 2 diabetic mice.

    Science.gov (United States)

    Geurts, Lucie; Everard, Amandine; le Ruyet, Pascale; Delzenne, Nathalie M; Cani, Patrice D

    2012-02-29

    Growing evidence suggests that the consumption of dairy products may contribute to a reduced incidence of cardiovascular risk factors, such as obesity, dyslipidemia, and type 2 diabetes. The fatty acid composition in milk fat, the duration of ripening, and the complexity of the food matrices are important factors that may interfere with the physiological impact. In this study, we treated genetic obese and type 2 diabetic mice (db/db) for 4 weeks with different dairy (cheese-based) products, differing by the duration of ripening (0, 15, or 35 days). We found that 35 days ripened product significantly improved glucose tolerance, an effect associated with a decreased adipose tissue lipid peroxide markers (TBARS and NAPDH-oxidase mRNA expression), without affecting body weight, food intake, and fat mass. Both fermented matrices significantly decreased the hepatic lipid content, without modifying plasma triglycerides or plasma total cholesterol. These data suggest that dairy products issued from longer ripening positively impact glucose tolerance, hepatic steatosis, and adipose tissue oxidative stress. Further investigations are warranted to decipher the interactions between milk products fermentation, lipids, and host metabolism. PMID:22300436

  17. Dietary energy sources affect the partition of body lipids and the hierarchy of energy metabolic pathways in growing pigs differing in feed efficiency

    OpenAIRE

    Gondret, Florence; Louveau, Isabelle; Mourot, Jacques; Duclos, Michel; Lagarrigue, Sandrine; Gilbert, Hélène; Van Milgen, Jacob

    2014-01-01

    The use and partition of feed energy are key elements in productive efficiency of pigs. This study aimed to determine whether dietary energy sources affect the partition of body lipids and tissue biochemical pathways of energy use between pigs differing in feed efficiency. Forty-eight barrows (pure Large White) from two divergent lines selected for residual feed intake (RFI), a measure of feed efficiency, were compared. From 74 d to 132 ± 0.5 d of age, pigs (n = 12 by line and by diet) were o...

  18. Lipid peroxidation in chicken meat during chilled storage as affected by antioxidants combined with low-dose gamma irradiation

    International Nuclear Information System (INIS)

    TBA values and carbonyl content for irradiated samples of ground chicken meat were higher than for nonirradiated samples. Addition of antioxidants tocopherol (natural) or BHT (synthetic) resulted in retardation of oxidative rancidity (p0.05). Meat treated with antioxidants prior to irradiation had lower TBA values as compared to untreated irradiated counterparts. Free fatty acid (FFA) values decreased after irradiation. Addition of antioxidants prior to irradiation showed a synergistic effect in decreasing FFA content. TLC of muscle lipids indicated a reduction in the triacylglcerols content with concomitant increases in FFA of all samples during storage. All irradiated meats were acceptable for consumption up to 4 wk of storage

  19. N-3 Polyunsaturated Fatty Acids Supplementation Does not Affect Changes of Lipid Metabolism Induced in Rats by Altered Thyroid Status

    Czech Academy of Sciences Publication Activity Database

    Rauchová, Hana; Vokurková, Martina; Pavelka, Stanislav; Behuliak, Michal; Tribulová, N.; Soukup, Tomáš

    2013-01-01

    Roč. 45, č. 7 (2013), s. 507-512. ISSN 0018-5043 R&D Projects: GA ČR(CZ) GA303/09/0570; GA ČR(CZ) GA304/08/0256; GA ČR(CZ) GAP304/12/0259; GA MŠk(CZ) 7AMB12SK158 Institutional research plan: CEZ:AV0Z50110509 Institutional support: RVO:67985823 Keywords : hypothyriodism * hyperthyroidism * mitochondrial glycerol-3-phosphate dehydrogenase * glucose * plasma lipids Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 2.038, year: 2013

  20. Oxidative stability and microstructure of 5% fish-oil-enriched granola bars added natural antioxidants derived from brown algaFucus vesiculosus

    DEFF Research Database (Denmark)

    Karadağ, Ayşe; Hermund, Ditte Baun; Jensen, Louise Helene Søgaard;

    2016-01-01

    oil droplets in granola bars. The oxidative stability of the bars at 20°C was evaluated over a period of 10 weeks by measuring the development of peroxides and volatile compounds using dynamic headspace gas chromatography mass spectrometry (DHS GC-MS). The physical microstructure was determined using......The aims of this study were to; 1) investigate the ability of Icelandic brown algae Fucus vesiculosus extracts to inhibit lipid oxidation in granola bars fortified with fish oil-in-water emulsion; 2) investigate whether addition of the seaweed extracts affected the physical microstructure of the...... efficacy of these two extracts was among other related to an improved incorporation of the fish oil-in-water emulsions in the bars, high total phenolic content, high radical scavenging activity together with high interfacial affinity of phenolic compounds and probably regeneration of tocopherol. Practical...

  1. How Do the Size, Charge and Shape of Nanoparticles Affect Amyloid β Aggregation on Brain Lipid Bilayer?

    Science.gov (United States)

    Kim, Yuna; Park, Ji-Hyun; Lee, Hyojin; Nam, Jwa-Min

    2016-01-01

    Here, we studied the effect of the size, shape, and surface charge of Au nanoparticles (AuNPs) on amyloid beta (Aβ) aggregation on a total brain lipid-based supported lipid bilayer (brain SLB), a fluid platform that facilitates Aβ-AuNP aggregation process. We found that larger AuNPs induce large and amorphous aggregates on the brain SLB, whereas smaller AuNPs induce protofibrillar Aβ structures. Positively charged AuNPs were more strongly attracted to Aβ than negatively charged AuNPs, and the stronger interactions between AuNPs and Aβ resulted in fewer β-sheets and more random coil structures. We also compared spherical AuNPs, gold nanorods (AuNRs), and gold nanocubes (AuNCs) to study the effect of nanoparticle shape on Aβ aggregation on the brain SLB. Aβ was preferentially bound to the long axis of AuNRs and fewer fibrils were formed whereas all the facets of AuNCs interacted with Aβ to produce the fibril networks. Finally, it was revealed that different nanostructures induce different cytotoxicity on neuroblastoma cells, and, overall, smaller Aβ aggregates induce higher cytotoxicity. The results offer insight into the roles of NPs and brain SLB in Aβ aggregation on the cell membrane and can facilitate the understanding of Aβ-nanostructure co-aggregation mechanism and tuning Aβ aggregate structures.

  2. Barred Owl [ds8

    Data.gov (United States)

    California Department of Resources — These data define the current range of Barred and hybrid Barred/Spotted Owls in California. The current range includes the coastal mountains of northern California...

  3. DIETARY MANGANESE INTAKE AND TYPE OF LIPID DO NOT AFFECT CLINICAL OR NEUROPSYCHOLOGICAL MEASURES IN HEALTHY YOUNG WOMEN

    Science.gov (United States)

    Because manganese (Mn) is potentially toxic, and because dietary fat type may affect Mn absorption, the objectives of the current study were to determine whether diets containing very low or very high amounts of Mn and enriched in either saturated or unsaturated fats affected measures of neuropsycho...

  4. Ascorbyl palmitate, gamma-tocopherol, and EDTA affect lipid oxidation in fish oil enriched salad dressing differently

    DEFF Research Database (Denmark)

    Let, M.B.; Jacobsen, Charlotte; Meyer, Anne S.

    2007-01-01

    The aim of the study was to investigate the ability of γ-tocopherol, ethylenediaminetetraacetate (EDTA), and ascorbyl palmitate to protect fish oil enriched salad dressing against oxidation during a 6 week storage period at room temperature. The lipid-soluble γ-tocopherol (220 and 880 µg g-1 of...... antioxidant, and overall peroxide values and volatiles were reduced by approximately 70 and 77-86%, respectively. Conversely, prooxidant effects were observed with a high concentration of ascorbyl palmitate (300 µg g-1 of fish oil), whereas a low concentration was slightly antioxidative (50 µg/g of fish oil......). Finally, a combination of all three antioxidants completely inhibited oxidation during storage, indicating that the prooxidant effects of ascorbyl palmitate were reverted or overshadowed by EDTA and γ-tocopherol....

  5. Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish

    Directory of Open Access Journals (Sweden)

    Hasumura Takahiro

    2012-08-01

    Full Text Available Abstract Background Visceral fat accumulation is one of the most important predictors of mortality in obese populations. Administration of green tea extract (GTE can reduce body fat and reduce the risk of obesity-related diseases in mammals. In this study, we investigated the effects and mechanisms of GTE on adiposity in diet-induced obese (DIO zebrafish. Methods Zebrafish at 3.5 to 4.5 months post-fertilization were allocated to four groups: non-DIO, DIO, DIO + 0.0025%GTE, and DIO + 0.0050%GTE. The non-DIO group was fed freshly hatched Artemia once daily (5 mg cysts/fish daily for 40 days. Zebrafish in the three DIO groups were fed freshly hatched Artemia three times daily (60 mg cysts/fish daily. Zebrafish in the DIO + 0.0025%GTE and DIO + 0.0050%GTE groups were exposed to GTE after the start of feeding three times daily for 40 days. Results Three-dimensional microcomputed tomography analysis showed that GTE exposure significantly decreased the volume of visceral but not subcutaneous fat tissue in DIO zebrafish. GTE exposure increased hepatic expression of the lipid catabolism genes ACOX1 (acyl-coenzyme A oxidase 1, palmitoyl, ACADM (acyl-coenzyme A dehydrogenase, c-4 to c-12 straight chain, and PPARA (peroxisome proliferator-activated receptor alpha. GTE exposure also significantly decreased the visceral fat expression of SOCS3 (suppressor of cytokine signaling 3b which inhibits leptin signaling. Conclusions The present results are consistent with those seen in mammals treated with GTE, supporting the validity of studying the effects of GTE in DIO zebrafish. Our results suggest that GTE exerts beneficial effects on adiposity, possibly by altering the expression of lipid catabolism genes and SOCS3.

  6. Estimated errors in vertical bar Vcd vertical bar / vertical bar Vcs vertical bar from semileptonic D decays

    International Nuclear Information System (INIS)

    We estimate statistical and systematic errors in the extraction of the CKM ratio vertical bar Vcd vertical bar / vertical bar Vcs vertical bar from exclusive D-meson semileptonic decays using lattice QCD and anticipated new experimental results

  7. Development of omega-3 rich energy bar with flaxseed

    OpenAIRE

    Mridula, D.; Singh, K. K.; Barnwal, P.

    2011-01-01

    Energy bar sample were prepared with different levels of flaxseed (0–20%) in addition to cereals and pulses with varying levels of sweeteners (45, 50, and 55%) to deliver a nutritious food to the consumer. The developed bars were evaluated for textural, colour, nutritional quality, sensory attributes and total microbial load. Different levels of flaxseed and sweeteners significantly affected the hue and chroma values of the energy bar. In general the level of flaxseed in energy bar did not af...

  8. Crystal Structures of the BAR-PH and PTB Domains of Human APPL1

    Energy Technology Data Exchange (ETDEWEB)

    Li,J.; Mao, X.; Dong, L.; Liu, F.; Tong, L.

    2007-01-01

    APPL1 interacts with adiponectin receptors and other important signaling molecules. It contains a BAR and a PH domain near its N terminus, and the two domains may function as a unit (BAR-PH domain). We report here the crystal structures of the BAR-PH and PTB domains of human APPL1. The structures reveal novel features for BAR domain dimerization and for the interactions between the BAR and PH domains. The BAR domain dimer of APPL1 contains two four-helical bundles, whereas other BAR domain dimers have only three helices in each bundle. The PH domain is located at the opposite ends of the BAR domain dimer. Yeast two-hybrid assays confirm the interactions between the BAR and PH domains. Lipid binding assays show that the BAR, PH, and PTB domains can bind phospholipids. The ability of APPL1 to interact with multiple signaling molecules and phospholipids supports an important role for this adaptor in cell signaling.

  9. Dietary energy sources affect the partition of body lipids and the hierarchy of energy metabolic pathways in growing pigs differing in feed efficiency.

    Science.gov (United States)

    Gondret, F; Louveau, I; Mourot, J; Duclos, M J; Lagarrigue, S; Gilbert, H; van Milgen, J

    2014-11-01

    The use and partition of feed energy are key elements in productive efficiency of pigs. This study aimed to determine whether dietary energy sources affect the partition of body lipids and tissue biochemical pathways of energy use between pigs differing in feed efficiency. Forty-eight barrows (pure Large White) from two divergent lines selected for residual feed intake (RFI), a measure of feed efficiency, were compared. From 74 d to 132 ± 0.5 d of age, pigs (n = 12 by line and by diet) were offered diets with equal protein and ME contents. A low fat, low fiber diet (LF) based on cereals and a high fat, high fiber diet (HF) where vegetal oils and wheat straw were used to partially substitute cereals, were compared. Irrespective of diet, gain to feed was 10% better (P percentage of PUFA, especially the EFA C18:2 and C18:3, was greater (P < 0.001) in backfat of HF-fed pigs. In both lines, these changes were associated with a marked decrease (P < 0.001) in the activities of two lipogenic enzymes, the fatty acid synthase (FASN) and the malic enzyme, in backfat. For the high RFI line, the hepatic lipid content was greater (P < 0.05) in pigs fed the HF diet than in pigs fed the LF diet, despite a reduced FASN activity (-32%; P < 0.001). In both lines, the HF diet also led to lower glycogen content (-70%) and lower glucokinase activity (-15%; P < 0.05) in the liver. These results show that dietary energy sources modified the partition of energy between liver, adipose tissue, and muscle in a way that was partly dependent of the genetics for feed efficiency, and changed the activity levels of biochemical pathways involved in lipid and glucose storage in tissues. PMID:25253805

  10. Perspectives on marine zooplankton lipids

    DEFF Research Database (Denmark)

    Kattner, G.; Hagen, W.; Lee, R.F.;

    2007-01-01

    climate change. The first addresses the role of lipids in membranes, storage lipids, and buoyancy with the following key question: How are the properties of membranes and deposits affected by the various types of lipids? The second deals with the importance of various types of lipids during reproduction...

  11. Dietary folate and choline status differentially affect lipid metabolism and behavior-mediated neurotransmitters in young rats

    Science.gov (United States)

    The relationship between choline and folate metabolisms is an important issue due to the essential role of these nutrients in brain plasticity and cognitive functions. Present study was designed to investigate whether modification of the dietary folate-choline status in young rats would affect brain...

  12. Comparison of the lipid properties of captive, healthy wild, and pansteatitis-affected wild Nile crocodiles (Crocodylus niloticus).

    Science.gov (United States)

    Osthoff, Gernot; Hugo, Arno; Bouwman, Henk; Buss, Peter; Govender, Danny; Joubert, Chris C; Swarts, Jannie C

    2010-01-01

    The results presented describe and compare the fatty acid composition and melting properties of captive, healthy wild, and pansteatitis-affected wild crocodiles (Crocodylus niloticus). Differences in fatty acid composition between intramuscular and adipose fat is noted in captive crocodiles, and the latter differs from wild crocodiles as a result of different diets. Adipose fat of healthy wild crocodiles differs minimally from diseased ones, respectively with 37.3+/-2.6% vs. 43.2+/-2.3% monounsaturated fatty acids, and 43.2+/-2.9% in dead crocodiles, while polyunsaturated fatty acids decrease from 27.3+/-1.9% to as low as 21.9+/-3.6% respectively. Of the unsaturated fatty acids 18:2n-6 decreased from 6.5+/-2.6% in unaffected crocodiles to 3.5+/-0.6% in highly affected and 3.2+/-0.4% in dead crocodiles, and 22:5n-3 from 2.8+/-0.6% to 1.8+/-0.3% and 2.2+/-0.3% respectively. The melting properties as determined by differential scanning calorimetry show that extracted adipose fat is a small degree softer in pansteatitis-affected tissue, specifically in the temperature range 7-36 degrees C, and does not contribute to the hard texture noted for adipose fat tissue of pansteatitis-affected animals. A high moisture content of 51.0+/-19.7% of the fat tissue of pansteatitis-affected animals vs.17.1+/-8.0% of healthy ones, suggests that physiological changes due to interstitial inflammation may contribute to the hard texture. PMID:19800020

  13. Effect of Protein-Lipid-Salt Interactions on Sodium Availability in the Mouth and Consequent Perception of Saltiness: As Affected by Hydration in Powders.

    Science.gov (United States)

    Yucel, Umut; Peterson, Devin G

    2015-09-01

    There is a broad need to reformulate lower sodium food products without affecting their original taste. The present study focuses on characterizing the role of protein-salt interactions on the salt release in low-moisture systems and saltiness perception during hydration. Sodium release from freeze-dried protein powders and emulsion powders formulated at different protein/lipid ratios (5:0 to 1:4) were characterized using a chromatography column modified with a porcine tongue. Emulsion systems with protein structured at the interface were found to have faster initial sodium release rates and faster hydration and were perceived to have a higher initial salt intensity with a lower salty aftertaste. In summary, exposure of the hydrophilic segments of the interface-structured proteins in emulsions was suggested to facilitate hydration and release of sodium during dissolution of low-moisture powder samples. PMID:26255668

  14. Selection for low erucic acid and genetic mapping of loci affecting the accumulation of very long-chain fatty acids in meadowfoam seed storage lipids.

    Science.gov (United States)

    Gandhi, S D; Kishore, V K; Crane, J M; Slabaugh, M B; Knapp, S J

    2009-06-01

    Erucic acid (22:1(13)) has been identified as an anti-nutritional compound in meadowfoam (Limnanthes alba) and other oilseeds in the Brassicales, a classification which has necessitated the development of low erucic acid cultivars for human consumption. The erucic acid concentrations of meadowfoam wild types (8%-24%) surpass industry standards for human consumption (affecting the accumulation of 22:1(13) and other very long-chain fatty acids (VLCFAs) in meadowfoam seed storage lipids. LE76, a low erucic acid line, was developed by 3 cycles of selection in an ethyl methanesulfonate-treated wildtype population. LE76 produced 3% 22:1(13), threefold less than the M0 population. Wildtype x LE76 F2 populations produced continuous, approximately normal erucic and dienoic acid distributions. Loss-of-function mutations apparently did not segregate and individuals with low 22:1(13) concentrations (affecting VLCFA profiles in seed storage lipids by genotyping and phenotyping wildtype x low erucic acid F2 progeny. Composite interval mapping identified 3 moderately large-effect erucic acid QTL. The low erucic acid parent transmitted favorable alleles for 2 of 3 QTL, suggesting low erucic acid cultivars can be developed by combining favorable alleles transmitted by wildtype and low erucic acid parents. PMID:19483773

  15. A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women

    DEFF Research Database (Denmark)

    Hallund, Jesper; Ravn-Haren, Gitte; Bügel, S.; Tholstrup, T.; Tetens, Inge

    2006-01-01

    ) completed a randomized, double-blind, placebo-controlled, crossover study. Women consumed daily a low-fat muffin, with or without a lignan complex, for 6 wk, separated by a 6-wk washout period. Serum ENL concentration, urinary ENL excretion, plasma concentrations of total cholesterol (TC), LDL cholesterol.......001) and ENL urinary excretion (P <0.001) were significantly higher after the lignan complex intervention period compared with placebo. Plasma concentrations of TC, LDL-C, HDL-C, TAG, lipoprotein oxidation lag time, TEAC and FRAP were not affected. Daily consumption for 6 wk of a low-fat muffin enriched...

  16. The ACTN3 R577X polymorphism affects the lipid profile and the prognosis of nutritional intervention in HIV-positive patients.

    Science.gov (United States)

    Aranalde, Laura C R; Pederzoli, Bruna S; Marten, Thais; Barros, Flavio C; Basso, Rossana P; Silveira, Jussara M; Valle, Sandra C; Pieniz, Simone; Araujo, Ronaldo C; Paredes-Gamero, Edgar J; Schadock, Ines; Schneider, Augusto; Barros, Carlos C

    2016-06-01

    The hypothesis of the present study is that the polymorphisms in the APOC3, CEPT, ACE, and ACTN3 genes can affect the outcome of nutritional intervention and the plasma lipid profile of HIV+ patients. To test the hypothesis, genetic material was collected from buccal cells, and serum was collected for biochemical analysis. Sixty-five patients were analyzed. The incorporation of protease inhibitor (PI) was more frequent in women (77% vs 33% in men). Nutritional intervention improved anthropometric parameters independent of the genotype. Patients with the RR genotype for the ACTN3 R577X polymorphism had lower glycemia (RR = 95.4 ± 6.5 mg/dL, RX = 102.6 ± 10.6 mg/dL, XX = 110.1 ± 16.3 mg/dL; P = .03) and a greater reduction in low-density lipoproteins (LDL) after intervention (LDL: RR = -23.7 ± 15.8 mg/dL, RX = 1.32 ± 5.13 mg/dL, XX = 30.21 ± 24.4 mg/dL; P = .01). Patients using PI had a negative response to dietary intervention regarding the levels of high-density lipoprotein (-2.4 ± 1.70 with PI, 2.56 ± 1.60 mg/dL without PI; P = .02), very low density lipoprotein (0.84 ± 2.73 with IP, -5.46 ± 3.37 mg/dL without PI; P = .03), and triglycerides (1.79 ± 13.22 with PI, -34.00 ± 17.67 mg/dL without PI; P = .052). This response was also independent of the genotype (P > 0.05) and suggested the need for oral lipid-lowering drugs in all HIV+ patients using PI. Our results indicate that the ACTN3 R577X polymorphism is a good predictor of both the lipid profile and the prognosis of nutritional intervention in reducing LDL in HIV+ patients. PMID:27188902

  17. Dissecting brick into bars

    OpenAIRE

    Feshchenko, Ivan; Radchenko, Danylo; Radzivilovsky, Lev; Tantsiura, Maksym

    2008-01-01

    An $N$-dimensional parallelepiped will be called a bar if and only if there are no more than $k$ different numbers among the lengths of its sides (the definition of bar depends on $k$). We prove that a parallelepiped can be dissected into finite number of bars iff the lengths of sides of the parallelepiped span a linear space of dimension no more than $k$ over $\\QQ$. This extends and generalizes a well-known theorem of Max Dehn about partition of rectangles into squares. Several other results...

  18. Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity

    Directory of Open Access Journals (Sweden)

    Layton Meredith J

    2012-12-01

    Full Text Available Abstract Background The α-isoform of the Type 1A Phosphoinositide 3-kinases (PI3Kα has protein kinase activity as well as phosphoinositide lipid kinase activity. The best described substrate for its protein kinase activity is its regulatory subunit, p85α, which becomes phosphorylated on Serine 608. Phosphorylation of Serine 608 has been reported to down-regulate its lipid kinase activity. Results We have assessed whether oncogenic mutants of PI3Kα, which have up-regulated lipid kinase activity, have altered levels of Serine 608 phosphorylation compared to wild type PI3Kα, and whether differential phosphorylation of Serine 608 contributes to increased activity of oncogenic forms of PI3Kα with point mutations in the helical or the kinase domains. Despite markedly increased lipid kinase activity, protein kinase activity was not altered in oncogenic compared to wild type forms of PI3Kα. By manipulating levels of phosphorylation of Serine 608 in vitro, we found no evidence that the protein kinase activity of PI3Kα affects its phosphoinositide lipid kinase activity in either wild-type or oncogenic mutants of PI3Kα. Conclusions Phosphorylation of p85α S608 is not a significant regulator of wild-type or oncogenic PI3Kα lipid kinase activity.

  19. Lipid Profile

    Science.gov (United States)

    ... be limited. Home Visit Global Sites Search Help? Lipid Profile Share this page: Was this page helpful? Also ... as: Lipid Panel; Coronary Risk Panel Formal name: Lipid Profile Related tests: Cholesterol ; HDL Cholesterol ; LDL Cholesterol ; Triglycerides ; ...

  20. Sports Season, Sports Bars

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ For foreigners in Beijing, the sports bar is a special place, a place to gather for watching matches and a place to feel the familiarity of home, while for some sports enthusiasts it serves as their second home.

  1. A diet rich in conjugated linoleic acid and butter increases lipid peroxidation but does not affect atherosclerotic, inflammatory, or diabetic risk markers in healthy young men

    DEFF Research Database (Denmark)

    Raff, Marianne; Tholstrup, Tine; Basu, Samar; Nonboe, Pernille; Sørensen, Martin Tang; Straarup, Ellen Marie

    2008-01-01

    fat intake. Our objective was to investigate the effect of CLA as part of a diet rich in butter as a source of milk fat on risk markers of atherosclerosis, inflammation, diabetes type 11, and lipid peroxidation. A total of 38 healthy young men were given a diet with 115g/d of CLA-rich fat (5.5 g/d CLA...... oil, a mixture of 39.4% cis9, trans11 and 38.5% trans10, cis12) or of control fat with a low content of CLA in a 5-wk double-blind, randomized, parallel intervention study. We collected blood and urine before and after the intervention. The fatty acid composition of plasma triacylglycerol, cholesterol......Intake of conjugated linoleic acid (CLA) has been demonstrated to beneficially affect risk markers of atherosclerosis and diabetes in rats. CLA is naturally found in milk fat, especially from cows fed a diet high in oleic acid, and increased CLA intake can occur concomitantly with increased milk...

  2. The bar instability revisited

    OpenAIRE

    Chiodi, Filippo; Andreotti, Bruno; Claudin, Philippe

    2012-01-01

    The river bar instability is revisited, using a hydrodynamical model based on Reynolds averaged Navier-Stokes equations. The results are contrasted with the standard analysis based on shallow water Saint-Venant equations. We first show that the stability of both transverse modes (ripples) and of small wavelength inclined modes (bars) predicted by the Saint-Venant approach are artefacts of this hydrodynamical approximation. When using a more reliable hydrodynamical model, the dispersion relati...

  3. $\\{Q\\bar{q}\\}\\{\\bar{Q}^{(')}q\\}$ molecular states

    OpenAIRE

    Zhang, Jian-Rong; Huang, Ming-Qiu(College of Science, National University of Defense Technology, 410073, Hunan, China)

    2009-01-01

    Masses for $\\{Q\\bar{q}\\}\\{\\bar{Q}^{(')}q\\}$ molecular states are systematically studied in QCD sum rules. The interpolating currents representing the related molecular states are proposed. Technically, contributions of the operators up to dimension six are included in operator product expansion (OPE). Mass spectra for molecular states with $\\{Q\\bar{q}\\}\\{\\bar{Q}^{(')}q\\}$ configurations are obtained.

  4. Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures

    Energy Technology Data Exchange (ETDEWEB)

    Pykäläinen, Anette; Boczkowska, Malgorzata; Zhao, Hongxia; Saarikangas, Juha; Rebowski, Grzegorz; Jansen, Maurice; Hakanen, Janne; Koskela, Essi V.; Peränen, Johan; Vihinen, Helena; Jokitalo, Eija; Salminen, Marjo; Ikonen, Elina; Dominguez, Roberto; Lappalainen, Pekka (Helsinki); (Penn)

    2013-05-29

    Bin/amphipysin/Rvs (BAR)-domain proteins sculpt cellular membranes and have key roles in processes such as endocytosis, cell motility and morphogenesis. BAR domains are divided into three subfamilies: BAR- and F-BAR-domain proteins generate positive membrane curvature and stabilize cellular invaginations, whereas I-BAR-domain proteins induce negative curvature and stabilize protrusions. We show that a previously uncharacterized member of the I-BAR subfamily, Pinkbar, is specifically expressed in intestinal epithelial cells, where it localizes to Rab13-positive vesicles and to the plasma membrane at intercellular junctions. Notably, the BAR domain of Pinkbar does not induce membrane tubulation but promotes the formation of planar membrane sheets. Structural and mutagenesis analyses reveal that the BAR domain of Pinkbar has a relatively flat lipid-binding interface and that it assembles into sheet-like oligomers in crystals and in solution, which may explain its unique membrane-deforming activity.

  5. Factors Affecting Gender Differences in the Association between Health-Related Quality of Life and Metabolic Syndrome Components: Tehran Lipid and Glucose Study.

    Directory of Open Access Journals (Sweden)

    Parisa Amiri

    Full Text Available Using structural equation modeling, this study is one of the first efforts aimed at assessing influential factors causing gender differences in the association between health-related quality of life (HRQoL and metabolic syndrome.A sample of 950 adults, from Tehran Lipid and Glucose Study were recruited for this cross sectional study in 2005-2007. Health-related quality of life was assessed using the Iranian version of SF-36. Metabolic syndrome components (MetSCs and physical and mental HRQoL were considered as continuous latent constructs explaining the variances of their observed components. Structural equation modeling was performed to examine the association between the constructs of MetSCs and the physical and mental HRQoL within the two gender groups.Based on the primary hypothesis, MetSCs and HRQoL were fitted in a model. The negative effect of MetSCs on HRQoL was found to be significant only in the physical domain and only in women. The proportion of all the cardio-metabolic risk factors as well as subscales of physical HRQoL that have been explained via the two constructs of MetSCs and HRQoL, respectively, were significantly higher in women. Physical activity in both men (β = 3.19, p<0.05 and women (β = 3.94, p<0.05, age (β = -3.28, p<0.05, education (β = 2.63, p<0.05 only in women and smoking (β = 2.28, p<0.05 just in men, directly affected physical HRQoL. Regarding the mental domain, physical activity (β = 3.37, p<0.05 and marital status (β = 3.44, p<0.05 in women and age (β = 2.01, p<0.05 in men were direct effective factors. Age and education in women as well as smoking in men indirectly affected physical HRQoL via MetSCs.Gender differences in the association between MetSCs and physical HRQoL could mostly be attributed to the different structures of both MetSCs and physical HRQoL constructs in men and women. Age and smoking are the most important socio-behavioral factors which could affect this gender-specific association in

  6. A postnatal diet containing phospholipids, processed to yield large, phospholipid-coated lipid droplets, affects specific cognitive behaviors in healthy male mice

    NARCIS (Netherlands)

    Schipper, Lidewij; van Dijk, Gertjan; Broersen, Laus M; Loos, Maarten; Bartke, Nana; Scheurink, Anton J.W.; van der Beek, Eline M

    2016-01-01

    BACKGROUND: Infant cognitive development can be positively influenced by breastfeeding rather than formula feeding. The composition of breast milk, especially lipid quality, and the duration of breastfeeding have been linked to this effect. OBJECTIVE: We investigated whether the physical properties

  7. Oxidative stability, lipid composition and nutritional value of ruminant meat as affected by animal feeding system, sex and common household treatments

    OpenAIRE

    Boe, Roberta

    2012-01-01

    Ruminant meats have been suffered from a negative health image related to the nature of their lipid fraction, mainly due to the higher content in SFA. Even so, ruminant edible fats are the major natural source of CLA, provide proteins of high biological value and important micronutrients, such as A, group B, D and E vitamins, minerals and essential fatty acids all these components are associated with potential health benefits. Oxidation of lipids in foods is the major biochemical process that...

  8. Evaluation of factors affecting on lipid extraction for recovery of fatty acids from Nannochloropsis oculata micro-algae to biodiesel production

    Directory of Open Access Journals (Sweden)

    Mohammad Malakootian

    2014-11-01

    Full Text Available Background: This study aimed at determining the appropriate method for dewatering and drying biomass and selecting a suitable organic solvent for lipid extraction. Methods: NannochloropsisOculata was cultured in Gillard F/2 medium and after reaching the end of the stationary growth phase, algal biomass was separated from aqueous by centrifuge and dried through three methods: Oven, Air-dried and Lyophilized. Soxhlet apparatus achieved lipid extraction of all samples: diethyl ether, n-hexane and n-pentane using three solvents. At each stage, the quantity and quality of the extracted lipids were determined by Gas Chromatography. Results: In all three drying methods, palmitic acid and palmitoleic acid, and most significantly fatty acid composition of microalgae were extracted. The fatty acid composition of palmitic acid extracted by Diethyl ether was significantly more than the other two solvents. Maximum production of triglyceride was observed in Lyophilized and air-dried microalgae where lipid extraction was performed with diethyl ether solvents and are 75.03% and 76.72% of fatty acid. Conclusion: The use of Lyophilized method for dewatering and drying of biomass and Diethyl ether as solvent for the extraction of lipids from biomass, studied in this paper, as compared to other methods, had higher yields and researches proved that the production of biodiesel from microalgae’s lipid was more efficient.

  9. Monitoring the laser marking of a bar code label

    International Nuclear Information System (INIS)

    A bar code label which has been laser marked onto the end of a nuclear fuel tube is tested for unacceptable depth penetration of the heat affected zone. The average gray level value of the bar code label is compared with a predetermined standard. The label is optically sensed by a video camera and a set of discrete digital values representative of the bar code label is generated. The average digital value representative of the bar code label is calculated and compared to a predetermined standard level derived from measurements of acceptable laser marked tubes. (author)

  10. Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells

    Science.gov (United States)

    Takahashi, Tomohiro; Sugawara, Wataru; Takiguchi, Yuya; Takizawa, Kento; Nakabayashi, Ami; Nakamura, Mitsuo; Nagano-Ito, Michiyo; Ichikawa, Shinichi

    2016-01-01

    Fatty liver disease is a condition in which abnormally large numbers of lipid droplets accumulate in liver cells. Fatty liver disease induces inflammation under conditions of oxidative stress and may result in cancer. To identify plants that protect against fatty liver disease, we examined the inhibitory effects of plant extracts on lipid droplet formation in mouse hepatoma cells. A screen of 98 water extracts of plants revealed 4 extracts with inhibitory effects. One of these extracts, Rubus suavissimus S. Lee (Tien-cha or Chinese sweet tea) leaf extract, which showed strong inhibitory effects, was tested in a mouse fatty liver model. In these mouse experiments, intake of the plant extract significantly protected mice against fatty liver disease without affecting body weight gain. Our results suggest that RSE directly affects liver cells and protects them from fatty liver disease.

  11. Highest Oxygen Bar

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The world’s highest altitude Lhalu Wetland in Tibet is rebounding from past environmental damage In Lhasa, where the oxygen content is just 60 percent of that of the plain area, a place known as the "natural oxygen bar"is highly prized by residents.

  12. The IPG BAR project

    NARCIS (Netherlands)

    Mentink, B.; Henriquez, L.; Van Niekerk, L.; Verheul, R.

    2013-01-01

    The booklets 'Making Patterns' and 'Using Patterns' describe two aspects of the the pattern method within the urban design process. The accompanying IPG BAR Pattern Library is a small pattern library of urban-airport symbiosis patterns. These documents are the result of the Interdisciplinary Projec

  13. Raising the Bar (3)

    NARCIS (Netherlands)

    Elhorst, P.; Abreu, M.; Amaral, P.; Bhattacharjee, A.; Corrado, L.; Fingleton, B.; Fuerst, F.; Garretsen, H.; Igliori, D.; Le Gallo, J.; McCann, P.; Monastiriotis, V.; Pryce, G.; Yu, J.

    2016-01-01

    This editorial summarizes and comments on the papers published in issue 11(3) so as to raise the bar in applied spatial economic research and highlight new trends. The first paper proposes spatial and a-spatial indicators to describe the networks of airline companies around the world. The second pap

  14. Warp evidence in precessing galactic bar models

    Science.gov (United States)

    Sánchez-Martín, P.; Romero-Gómez, M.; Masdemont, J. J.

    2016-04-01

    Most galaxies have a warped shape when they are seen edge-on. The reason for this curious form is not completely known so far, so in this work we apply dynamical system tools to contribute to its explanation. Starting from a simple, but realistic model formed by a bar and a disc, we study the effect of a small misalignment between the angular momentum of the system and its angular velocity. To this end, a precession model was developed and considered, assuming that the bar behaves like a rigid body. After checking that the periodic orbits inside the bar continue to be the skeleton of the inner system even after inflicting a precession to the potential, we computed the invariant manifolds of the unstable periodic orbits departing from the equilibrium points at the ends of the bar to find evidence of their warped shapes. As is well known, the invariant manifolds associated with these periodic orbits drive the arms and rings of barred galaxies and constitute the skeleton of these building blocks. Looking at them from a side-on viewpoint, we find that these manifolds present warped shapes like those recognised in observations. Lastly, test particle simulations have been performed to determine how the stars are affected by the applied precession, this way confirming the theoretical results.

  15. Observations of offshore bar decay

    DEFF Research Database (Denmark)

    Aagaard, Troels; Kroon, Aart; Greenwood, Brian; Hughes, Michael G

    2010-01-01

    the upper shoreface, and finally a stage of decaying bar form through loss of sediment volume at the outer boundary of the upper shoreface. The phenomenon has been previously documented in the Netherlands, the USA, the Canadian Great Lakes, and in New Zealand, but our present understanding of the...... morphodynamic processes and sediment transport pathways involved in bar decay is limited. In this paper, long-term, net offshore bar migration is investigated at Vejers Beach, located on the North Sea coast of Denmark where offshore bar migration rates are of the order of 45–55 m a-1. A wave height...... transformation model confirmed that the decay of the outer bar results in increased wave heights and undertow speeds at the more landward bar potentially causing this bar to speed up its offshore migration. The causes for outer bar decay were investigated through field measurements of sediment transport at the...

  16. Implementation of viscoelastic Hopkinson bars

    OpenAIRE

    Govender R; Cloete T.; Curry R.

    2012-01-01

    Knowledge of the properties of soft, viscoelastic materials at high strain rates are important in furthering our understanding of their role during blast or impact events. Testing these low impedance materials using a metallic split Hopkinson pressure bar setup results in poor signal to noise ratios due to impedance mismatching. These difficulties are overcome by using polymeric Hopkinson bars. Conventional Hopkinson bar analysis cannot be used on the polymeric bars due to the viscoelastic na...

  17. Dark Matter Trapping by Stellar Bars: The Shadow Bar

    CERN Document Server

    Petersen, Michael S; Katz, Neal

    2016-01-01

    We investigate the complex interactions between the stellar disc and the dark-matter halo during bar formation and evolution using N-body simulations with fine temporal resolution and optimally chosen spatial resolution. We find that the forming stellar bar traps dark matter in the vicinity of the stellar bar into bar-supporting orbits. We call this feature the shadow bar. The shadow bar modifies both the location and magnitude of the angular momentum transfer between the disc and dark matter halo and adds 10 per cent to the mass of the stellar bar over 4 Gyr. The shadow bar is potentially observable by its density and velocity signature in spheroid stars and by direct dark matter detection experiments. Numerical tests demonstrate that the shadow bar can diminish the rate of angular momentum transport from the bar to the dark matter halo by more than a factor of three over the naive dynamical friction prediction, and thus provides a possible physical explanation for the observed prevalence of fast bars in nat...

  18. Dark Matter Trapping by Stellar Bars: The Shadow Bar

    Science.gov (United States)

    Petersen, Michael S.; Weinberg, Martin D.; Katz, Neal

    2016-09-01

    We investigate the complex interactions between the stellar disc and the dark-matter halo during bar formation and evolution using N-body simulations with fine temporal resolution and optimally chosen spatial resolution. We find that the forming stellar bar traps dark matter in the vicinity of the stellar bar into bar-supporting orbits. We call this feature the shadow bar. The shadow bar modifies both the location and magnitude of the angular momentum transfer between the disc and dark matter halo and adds 10 per cent to the mass of the stellar bar over 4 Gyr. The shadow bar is potentially observable by its density and velocity signature in spheroid stars and by direct dark matter detection experiments. Numerical tests demonstrate that the shadow bar can diminish the rate of angular momentum transport from the bar to the dark matter halo by more than a factor of three over the rate predicted by dynamical friction with an untrapped dark halo, and thus provides a possible physical explanation for the observed prevalence of fast bars in nature.

  19. Cooling of rectangular bars

    International Nuclear Information System (INIS)

    A solution of the time-transient Heat Transfer Differential Equation in rectangular coordinates is presented, leading to a model which describes the temperature drop with time in rectangular bars. It is similar to an other model for cilindrical bars which has been previously developed in the Laboratory of Mechanical Metallurgy of UFRGS. Following these models, a generalization has been made, which permits cooling time evaluation for all profiles. These results are compared with experimental laboratory data in the 1200 to 8000C range. Some other existing models were also studied which have the purpose of studing the same phenomenon. Their mathematical forms and their evaluated values are analyzed and compared with experimental ones. (Author)

  20. The bar instability revisited

    CERN Document Server

    Chiodi, Filippo; Claudin, Philippe

    2012-01-01

    The river bar instability is revisited, using a hydrodynamical model based on Reynolds averaged Navier-Stokes equations. The results are contrasted with the standard analysis based on shallow water Saint-Venant equations. We first show that the stability of both transverse modes (ripples) and of small wavelength inclined modes (bars) predicted by the Saint-Venant approach are artefacts of this hydrodynamical approximation. When using a more reliable hydrodynamical model, the dispersion relation does not present any maximum of the growth rate when the sediment transport is assumed to be locally saturated. The analysis therefore reveals the fundamental importance of the relaxation of sediment transport towards equilibrium as it it is responsible for the stabilisation of small wavelength modes. This dynamical mechanism is characterised by the saturation number, defined as the ratio of the saturation length to the water depth Lsat/H. This dimensionless number controls the transition from ripples (transverse patte...

  1. Diacylglycerol oil does not affect portal vein transport of nonesterified fatty acids but decreases the postprandial plasma lipid response in catheterized Pigs

    DEFF Research Database (Denmark)

    Kristensen, Janni Brogaard; Jørgensen, Henry; Mu, Huiling

    2006-01-01

    responsible for the positive effects. We examined the portal vein transport of NEFA and other lipid related variables, in response to DAG and triacylglycerol (TAG) bolus feeding and a bolus of standard pig feed in 4 portal vein and mesenteric artery catheterized pigs. Also, the effect of the boluses on...

  2. The Possible Heavy Tetraquarks $qQ\\bar q \\bar Q$, $qq\\bar Q \\bar Q$ and $qQ\\bar Q \\bar Q$

    OpenAIRE

    CUI, Ying; Chen, Xiao-Lin; Deng, Wei-Zhen; Zhu, Shi-Lin

    2006-01-01

    Assuming X(3872) is a $qc \\bar q \\bar c$ tetraquark and using its mass as input, we perform a schematic study of the masses of possible heavy tetraquarks using the color-magnetic interaction with the flavor symmetry breaking corrections.

  3. A Study on a Bell Type Stabilizer Bar of a Small Coaxial Helicopter

    Science.gov (United States)

    Sunada, Shigeru; Kikuchi, Atsushi; Tokutake, Hiroshi

    The motion of a stabilizer bar of the small coaxial helicopter was analyzed in the previous study. It has been made clear by the measurements on the motion of the stabilizer bar that the following two revisions are required in the analysis. (1) The motion of stabilizer bar is affected by the upper rotor. (2) Neither of the terms in the moment acting on the stabilizer bar at its hinge, kββ+kββ, can be ignored.

  4. The effects of lipids on channel function

    OpenAIRE

    Lee, Anthony G.

    2009-01-01

    Anionic lipids affect the function of many channels, including connexins, as shown in a recent report in BMC Biology. These effects might follow from direct binding of the anionic lipids to the channels.

  5. Characterization of the Aroma-Active, Phenolic, and Lipid Profiles of the Pistachio (Pistacia vera L.) Nut as Affected by the Single and Double Roasting Process.

    Science.gov (United States)

    Rodríguez-Bencomo, Juan José; Kelebek, Hasim; Sonmezdag, Ahmet Salih; Rodríguez-Alcalá, Luis Miguel; Fontecha, Javier; Selli, Serkan

    2015-09-01

    The pistachio (Pistacia vera L.) nut is one of the most widely consumed edible nuts in the world. However, it is the roasting process that makes the pistachio commercially viable and valuable as it serves as the key step to improving the nut's hallmark sensory characteristics including flavor, color, and texture. Consequently, the present study explores the effects of the single-roasting and double-roasting process on the pistachio's chemical composition, specifically aroma-active compounds, polyphenols, and lipids. Results showed the total polyphenol content of increased with the roasting treatment; however, not all phenolic compounds demonstrated this behavior. With regard to the aroma and aroma-active compounds, the results indicated that roasting process results in the development of characteristics and pleasant aroma of pistachio samples due to the Maillard reaction. With regard to lipids, the pistachio roasting treatment reduced the concentration of CN38 diacylglycerides while increasing the amount of elaidic acid. PMID:26301818

  6. Green tea powder and Lactobacillus plantarum affect gut microbiota, lipid metabolism and inflammation in high-fat fed C57BL/6J mice

    OpenAIRE

    Axling Ulrika; Olsson Crister; Xu Jie; Fernandez Céline; Larsson Sara; Ström Kristoffer; Ahrné Siv; Holm Cecilia; Molin Göran; Berger Karin

    2012-01-01

    Abstract Background Type 2 diabetes is associated with obesity, ectopic lipid accumulation and low-grade inflammation. A dysfunctional gut microbiota has been suggested to participate in the pathogenesis of the disease. Green tea is rich in polyphenols and has previously been shown to exert beneficial metabolic effects. Lactobacillus plantarum has the ability to metabolize phenolic acids. The health promoting effect of whole green tea powder as a prebiotic compound has not been thoroughly inv...

  7. Computer Simulations of Lipid Bilayers and Proteins

    DEFF Research Database (Denmark)

    Sonne, Jacob

    2006-01-01

    The importance of computer simulations in lipid bilayer research has become more prominent for the last couple of decades and as computers get even faster, simulations will play an increasingly important part of understanding the processes that take place in and across cell membranes. This thesis...... entitled Computer simulations of lipid bilayers and proteins describes two molecular dynamics (MD) simulation studies of pure lipid bilayers as well as a study of a transmembrane protein embedded in a lipid bilayer matrix. Below follows a brief overview of the thesis. Chapter 1. This chapter is a short......, Pressure profile calculations in lipid bilayers: A lipid bilayer is merely $\\sim$5~nm thick, but the lateral pressure (parallel to the bilayer plane) varies several hundred bar on this short distance (normal to the bilayer). These variations in the lateral pressure are commonly referred to as the pressure...

  8. Dynamical Evolution of Barred Galaxies

    OpenAIRE

    Athanassoula, E

    2005-01-01

    Angular momentum redistribution within barred galaxies drives their dynamical evolution. Angular momentum is emitted mainly by near-resonant material in the bar region and absorbed by resonant material mainly in the outer disc and in the halo. This exchange determines the strength of the bar, the decrease of its pattern speed, as well as its morphology. If the galaxy has also a gaseous component and/or a companion or satellite, then these also take part in the angular momentum exchange. Durin...

  9. [Development of soy-based protein candy bars for athletes].

    Science.gov (United States)

    Wittig de Penna, E; Bunger, A; Sansur, M; López, L; Santana, R

    1993-09-01

    Two varieties of soy-based candy bars were developed for sportsmen who need a higher protein intake. The two varieties, almond and nut, were covered with chocolate. The ingredients used were isolated soy protein, texturized soy flour, milk solids, cocoa powder, toasted oat, nuts, almonds, authorized flavors, preservants and antioxidants. Controls were carried out in the optimized products, and the results indicate a very good sensory and microbiological quality. The average nutritional composition of both varieties is: 12,4% proteins, 9% lipids and 58,7% carbohydrates, and the caloric value is 375,2 kcal/100 g. A shelf-life study was performed at room temperature with the candy bars packed in an aluminium foil. Determining that the quality remains without significant changes during 30 days for the nut candy, and at least for 60 days for the almond candy bar. PMID:8779627

  10. Milk lipids

    Science.gov (United States)

    Milk fat conveys a number of desirable qualities to food, and various lipid components contribute to human nutrition and health. Over 96% of milk lipids consist of triacylglycerols, which contain a variety of fatty acids. Di- and monoacylglycerols, free fatty acids, sterols, and phospho-, glyco-,...

  11. Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Qian-fei; Liu, Xin; O' Connell, Jeff; Peng, Ze; Krauss, Ronald M.; Rainwater, David L.; VandeBerg, John L.; Rubin, Edward M.; Cheng, Jan-Fang; Pennacchio, Len A.

    2003-09-15

    Genetic studies in non-human primates serve as a potential strategy for identifying genomic intervals where polymorphisms impact upon human disease-related phenotypes. It remains unclear, however, whether independently arising polymorphisms in orthologous regions of non-human primates leads to similar variation in a quantitative trait found in both species. To explore this paradigm, we studied a baboon apolipoprotein gene cluster (APOA1/C3/A4/A5) for which the human gene orthologs have well established roles in influencing plasma HDL-cholesterol and triglyceride concentrations. Our extensive polymorphism analysis of this 68 kb gene cluster in 96 pedigreed baboons identified several haplotype blocks each with limited diversity, consistent with haplotype findings in humans. To determine whether baboons, like humans, also have particular haplotypes associated with lipid phenotypes, we genotyped 634 well characterized baboons using 16 haplotype tagging SNPs. Genetic analysis of single SNPs, as well as haplotypes, revealed an association of APOA5 and APOC3 variants with HDL cholesterol and triglyceride concentrations, respectively. Thus, independent variation in orthologous genomic intervals does associate with similar quantitative lipid traits in both species, supporting the possibility of uncovering human QTL genes in a highly controlled non-human primate model.

  12. Lipid metabolism in mitochondrial membranes.

    Science.gov (United States)

    Mayr, Johannes A

    2015-01-01

    Mitochondrial membranes have a unique lipid composition necessary for proper shape and function of the organelle. Mitochondrial lipid metabolism involves biosynthesis of the phospholipids phosphatidylethanolamine, cardiolipin and phosphatidylglycerol, the latter is a precursor of the late endosomal lipid bis(monoacylglycero)phosphate. It also includes mitochondrial fatty acid synthesis necessary for the formation of the lipid cofactor lipoic acid. Furthermore the synthesis of coenzyme Q takes place in mitochondria as well as essential parts of the steroid and vitamin D metabolism. Lipid transport and remodelling, which are necessary for tailoring and maintaining specific membrane properties, are just partially unravelled. Mitochondrial lipids are involved in organelle maintenance, fission and fusion, mitophagy and cytochrome c-mediated apoptosis. Mutations in TAZ, SERAC1 and AGK affect mitochondrial phospholipid metabolism and cause Barth syndrome, MEGDEL and Sengers syndrome, respectively. In these disorders an abnormal mitochondrial energy metabolism was found, which seems to be due to disturbed protein-lipid interactions, affecting especially enzymes of the oxidative phosphorylation. Since a growing number of enzymes and transport processes are recognised as parts of the mitochondrial lipid metabolism, a further increase of lipid-related disorders can be expected. PMID:25082432

  13. Implementation of viscoelastic Hopkinson bars

    Science.gov (United States)

    Curry, R.; Cloete, T.; Govender, R.

    2012-08-01

    Knowledge of the properties of soft, viscoelastic materials at high strain rates are important in furthering our understanding of their role during blast or impact events. Testing these low impedance materials using a metallic split Hopkinson pressure bar setup results in poor signal to noise ratios due to impedance mismatching. These difficulties are overcome by using polymeric Hopkinson bars. Conventional Hopkinson bar analysis cannot be used on the polymeric bars due to the viscoelastic nature of the bar material. Implementing polymeric Hopkinson bars requires characterization of the viscoelastic properties of the material used. In this paper, 30 mm diameter Polymethyl Methacrylate bars are used as Hopkinson pressure bars. This testing technique is applied to polymeric foam called Divinycell H80 and H200. Although there is a large body of of literature containing compressive data, this rarely deals with strain rates above 250s-1 which becomes increasingly important when looking at the design of composite structures where energy absorption during impact events is high on the list of priorities. Testing of polymeric foams at high strain rates allows for the development of better constitutive models.

  14. Implementation of viscoelastic Hopkinson bars

    Directory of Open Access Journals (Sweden)

    Govender R.

    2012-08-01

    Full Text Available Knowledge of the properties of soft, viscoelastic materials at high strain rates are important in furthering our understanding of their role during blast or impact events. Testing these low impedance materials using a metallic split Hopkinson pressure bar setup results in poor signal to noise ratios due to impedance mismatching. These difficulties are overcome by using polymeric Hopkinson bars. Conventional Hopkinson bar analysis cannot be used on the polymeric bars due to the viscoelastic nature of the bar material. Implementing polymeric Hopkinson bars requires characterization of the viscoelastic properties of the material used. In this paper, 30 mm diameter Polymethyl Methacrylate bars are used as Hopkinson pressure bars. This testing technique is applied to polymeric foam called Divinycell H80 and H200. Although there is a large body of of literature containing compressive data, this rarely deals with strain rates above 250s−1 which becomes increasingly important when looking at the design of composite structures where energy absorption during impact events is high on the list of priorities. Testing of polymeric foams at high strain rates allows for the development of better constitutive models.

  15. Dynamical Evolution of Barred Galaxies

    CERN Document Server

    Athanassoula, E

    2005-01-01

    Angular momentum redistribution within barred galaxies drives their dynamical evolution. Angular momentum is emitted mainly by near-resonant material in the bar region and absorbed by resonant material mainly in the outer disc and in the halo. This exchange determines the strength of the bar, the decrease of its pattern speed, as well as its morphology. If the galaxy has also a gaseous component and/or a companion or satellite, then these also take part in the angular momentum exchange. During the evolution a bar structure forms in the inner parts of the halo as well. This bar is shorter and fatter than the disc bar and stays so all through the simulation, although its length grows considerably with time. Viewed edge-on, the bar in the disc component acquires a boxy or peanut shape. I describe the families of periodic orbits that explain such structures and review the observations showing that boxy/peanut `bulges' are in fact just bars seen edge-on.

  16. Lipid oxidation in fish oil enriched oil-in-water emulsions and cream cheese with pre-emulsified fish oil is affected differently by the emulsifier used

    DEFF Research Database (Denmark)

    Horn, Anna Frisenfeldt; Nielsen, Nina Skall; Andersen, Ulf;

    emulsifier. The antioxidative properties of milk proteins make them an obvious choice as emulsifiers in delivery emulsions. Previous studies have furthermore shown that a combination of proteins and phospholipids may increase the thickness of the interfacial layer in an emulsion. This presentation will...... include results from studies on lipid oxidation in simple oil-in-water emulsions prepared with milk proteins alone or combinations of milk proteins and phospholipids. In addition, a study on fish oil enriched cream cheese will be presented. In this study, the cream cheese was enriched with either neat...... fish oil or a fish oil-in-water delivery emulsion prepared with whey protein isolate, sodium caseinate or a commercially available emulsifier that consisted of ~20% milk phospholipids and ~50% milk proteins. Results showed that simple emulsions prepared with a combination of milk proteins and...

  17. Tamoxifen affects glucose and lipid metabolism parameters, causes browning of subcutaneous adipose tissue and transient body composition changes in C57BL/6NTac mice

    International Nuclear Information System (INIS)

    Tamoxifen is a selective estrogen receptor (ER) modulator which is widely used to generate inducible conditional transgenic mouse models. Activation of ER signaling plays an important role in the regulation of adipose tissue (AT) metabolism. We therefore tested the hypothesis that tamoxifen administration causes changes in AT biology in vivo. 12 weeks old male C57BL/6NTac mice were treated with either tamoxifen (n = 18) or vehicle (n = 18) for 5 consecutive days. Tamoxifen treatment effects on body composition, energy homeostasis, parameters of AT biology, glucose and lipid metabolism were investigated up to an age of 18 weeks. We found that tamoxifen treatment causes: I) significantly increased HbA1c, triglyceride and free fatty acid serum concentrations (p < 0.01), II) browning of subcutaneous AT and increased UCP-1 expression, III) increased AT proliferation marker Ki67 mRNA expression, IV) changes in adipocyte size distribution, and V) transient body composition changes. Tamoxifen may induce changes in body composition, whole body glucose and lipid metabolism and has significant effects on AT biology, which need to be considered when using Tamoxifen as a tool to induce conditional transgenic mouse models. Our data further suggest that tamoxifen-treated wildtype mice should be characterized in parallel to experimental transgenic models to control for tamoxifen administration effects. - Highlights: • Tamoxifen treatment causes significantly increased HbA1c, triglyceride and free fatty acid serum concentrations. • Tamoxifen induces browning of subcutaneous AT and increased UCP-1 expression. • Tamoxifen changes adipocyte size distribution, and transient body composition

  18. Tamoxifen affects glucose and lipid metabolism parameters, causes browning of subcutaneous adipose tissue and transient body composition changes in C57BL/6NTac mice

    Energy Technology Data Exchange (ETDEWEB)

    Hesselbarth, Nico; Pettinelli, Chiara [Department of Medicine, University of Leipzig, D-04103 Leipzig (Germany); Gericke, Martin [Institute of Anatomy, University of Leipzig, D-04103 Leipzig (Germany); Berger, Claudia [IFB Adiposity Disease, Core Unit Animal Models, University of Leipzig, D-04103 Leipzig (Germany); Kunath, Anne [German Center for Diabetes Research (DZD), Leipzig (Germany); Stumvoll, Michael; Blüher, Matthias [Department of Medicine, University of Leipzig, D-04103 Leipzig (Germany); Klöting, Nora, E-mail: nora.kloeting@medizin.uni-leipzig.de [IFB Adiposity Disease, Core Unit Animal Models, University of Leipzig, D-04103 Leipzig (Germany)

    2015-08-28

    Tamoxifen is a selective estrogen receptor (ER) modulator which is widely used to generate inducible conditional transgenic mouse models. Activation of ER signaling plays an important role in the regulation of adipose tissue (AT) metabolism. We therefore tested the hypothesis that tamoxifen administration causes changes in AT biology in vivo. 12 weeks old male C57BL/6NTac mice were treated with either tamoxifen (n = 18) or vehicle (n = 18) for 5 consecutive days. Tamoxifen treatment effects on body composition, energy homeostasis, parameters of AT biology, glucose and lipid metabolism were investigated up to an age of 18 weeks. We found that tamoxifen treatment causes: I) significantly increased HbA{sub 1c}, triglyceride and free fatty acid serum concentrations (p < 0.01), II) browning of subcutaneous AT and increased UCP-1 expression, III) increased AT proliferation marker Ki67 mRNA expression, IV) changes in adipocyte size distribution, and V) transient body composition changes. Tamoxifen may induce changes in body composition, whole body glucose and lipid metabolism and has significant effects on AT biology, which need to be considered when using Tamoxifen as a tool to induce conditional transgenic mouse models. Our data further suggest that tamoxifen-treated wildtype mice should be characterized in parallel to experimental transgenic models to control for tamoxifen administration effects. - Highlights: • Tamoxifen treatment causes significantly increased HbA{sub 1c}, triglyceride and free fatty acid serum concentrations. • Tamoxifen induces browning of subcutaneous AT and increased UCP-1 expression. • Tamoxifen changes adipocyte size distribution, and transient body composition.

  19. Green tea powder and Lactobacillus plantarum affect gut microbiota, lipid metabolism and inflammation in high-fat fed C57BL/6J mice

    Directory of Open Access Journals (Sweden)

    Axling Ulrika

    2012-11-01

    Full Text Available Abstract Background Type 2 diabetes is associated with obesity, ectopic lipid accumulation and low-grade inflammation. A dysfunctional gut microbiota has been suggested to participate in the pathogenesis of the disease. Green tea is rich in polyphenols and has previously been shown to exert beneficial metabolic effects. Lactobacillus plantarum has the ability to metabolize phenolic acids. The health promoting effect of whole green tea powder as a prebiotic compound has not been thoroughly investigated previously. Methods C57BL/6J mice were fed a high-fat diet with or without a supplement of 4% green tea powder (GT, and offered drinking water supplemented with Lactobacillus plantarum DSM 15313 (Lp or the combination of both (Lp + GT for 22 weeks. Parameters related to obesity, glucose tolerance, lipid metabolism, hepatic steatosis and inflammation were examined. Small intestinal tissue and caecal content were collected for bacterial analysis. Results Mice in the Lp + GT group had significantly more Lactobacillus and higher diversity of bacteria in the intestine compared to both mice in the control and the GT group. Green tea strongly reduced the body fat content and hepatic triacylglycerol and cholesterol accumulation. The reduction was negatively correlated to the amount of Akkermansia and/or the total amount of bacteria in the small intestine. Markers of inflammation were reduced in the Lp + GT group compared to control. PLS analysis of correlations between the microbiota and the metabolic variables of the individual mice showed that relatively few components of the microbiota had high impact on the correlation model. Conclusions Green tea powder in combination with a single strain of Lactobacillus plantarum was able to promote growth of Lactobacillus in the intestine and to attenuate high fat diet-induced inflammation. In addition, a component of the microbiota, Akkermansia, correlated negatively with several metabolic parameters

  20. Increasing the stearate content in seed oil of Brassica juncea by heterologous expression of MlFatB affects lipid content and germination frequency of transgenic seeds.

    Science.gov (United States)

    Bhattacharya, Surajit; Sinha, Saheli; Das, Natasha; Maiti, Mrinal K

    2015-11-01

    Fatty acids from dietary lipids can impart both beneficial and harmful health effects. The compositional balance between saturated and unsaturated fatty acids plays a decisive role in maintaining the physiological harmony, proper growth and development in the human system. In case of Brassica juncea seed oil, the level of saturated fatty acid, especially desirable stearate is very much lower than the recommended value, along with a high content of nutritionally undesirable erucic acid. Therefore, in order to shift the carbon flux towards the production of stearate at the expense of erucate, the MlFatB gene encoding a FatB thioesterase from Madhuca longifolia (latifolia) was expressed heterologously in seed tissues of B. juncea. The functional MlFatB competed with the highly active endogenous BjFatA thioesterase, and the transgenic B. juncea lines showed noteworthy changes in their seed fatty acid profiles. The proportion of stearate increased up to 16-fold, constituting almost 31% of the total fatty acids along with the production of arachidic acid in significant amount (up to ∼11%). Moreover, the content of erucate was reduced up to 71% in the seed oils of transgenic lines. Although a nutritionally desirable fatty acid profile was achieved, the transgenic seeds exhibit reduction or abolition of seed germination in addition to a decrease in seed lipid content. The findings of the present study revealing the stearoyl-ACP thioesterase-mediated enhancement of the stearate content that is associated with reduced germination frequency of transgenic B. juncea seeds, may explain why no natural or induced stearate-rich Brassica has been found or developed. Furthermore, this study also suggests that the newly characterized MlFatB is a potential candidate gene for refined metabolic engineering strategy in B. juncea or other plant species for increasing stearate content in seed oil. PMID:26351151

  1. Niobium in engineering bar steels

    International Nuclear Information System (INIS)

    The use of niobium as a microalloying addition to hot rolled and cold finished bars offers many opportunities to achieve enhanced mechanical properties in a very cost effective manner. By the addition of niobium (sometimes in combination with vanadium) to selected carbon steel grades, it is possible to produce hot rolled bars with minimum yield strengths up to 689 MPa (100 ksi) and cold finished bars with yield strengths up to 1035 MPa (150 ksi). These high-strength-low-alloy bars have a myriad of applications particularly for automotive parts such as shafts, stabilizer bars, tie rods, piston rods, fasteners such as U-bolts, brackets, and various transmission parts. Of particular value has been the specification of Nb-microalloyed steels for such hot forgings as connecting rods and caps, and weld yokes a situation which has permitted elimination of post-forging heat treatment (quenching and tempering). Significant reductions in cost and energy consumption have been realized

  2. Bars in Cuspy Dark Halos

    CERN Document Server

    Dubinski, John; Shlosman, Isaac

    2008-01-01

    We examine the bar instability in models with an exponential disk and a cuspy NFW-like dark matter (DM) halo inspired by cosmological simulations. Bar evolution is studied as a function of numerical resolution in a sequence of models spanning 10K to 100M DM particles - including a multi-mass model with an effective resolution of 10G. The goal is to find convergence in dynamical behaviour. We characterize the bar growth, the buckling instability, pattern speed decay through resonant transfer of angular momentum, and possible destruction of the DM halo cusp. Overall, most characteristics converge in behaviour in detail for halos containing more than 10M particles. Notably, the formation of the bar does not destroy the density cusp in this case. These higher resolution simulations clearly illustrate the importance of discrete resonances in transporting angular momentum from the bar to the halo.

  3. Galaxy Zoo: CANDELS Barred Disks and Bar Fractions

    CERN Document Server

    Simmons, B D; Lintott, Chris; Masters, Karen L; Willett, Kyle W; Keel, William C; Smethurst, R J; Cheung, Edmond; Nichol, Robert C; Schawinski, Kevin; Rutkowski, Michael; Kartaltepe, Jeyhan S; Bell, Eric F; Casteels, Kevin R V; Conselice, Christopher J; Almaini, Omar; Ferguson, Henry C; Fortson, Lucy; Hartley, William; Kocevski, Dale; Koekemoer, Anton M; McIntosh, Daniel H; Mortlock, Alice; Newman, Jeffrey A; Ownsworth, Jamie; Bamford, Steven; Dahlen, Tomas; Faber, Sandra M; Finkelstein, Steven L; Fontana, Adriano; Galametz, Audrey; Grogin, N A; Grutzbauch, Ruth; Guo, Yicheng; Haussler, Boris; Jek, Kian J; Kaviraj, Sugata; Lucas, Ray A; Peth, Michael; Salvato, Mara; Wiklind, Tommy; Wuyts, Stijn

    2014-01-01

    The formation of bars in disk galaxies is a tracer of the dynamical maturity of the population. Previous studies have found that the incidence of bars in disks decreases from the local Universe to z ~ 1, and by z > 1 simulations predict that bar features in dynamically mature disks should be extremely rare. Here we report the discovery of strong barred structures in massive disk galaxies at z ~ 1.5 in deep rest-frame optical images from CANDELS. From within a sample of 876 disk galaxies identified by visual classification in Galaxy Zoo, we identify 123 barred galaxies. Selecting a sub-sample within the same region of the evolving galaxy luminosity function (brighter than L*), we find that the bar fraction across the redshift range 0.5< z < 2 (f_bar = 10.7 +6.3 -3.5% after correcting for incompleteness) does not significantly evolve. We discuss the implications of this discovery in the context of existing simulations and our current understanding of the way disk galaxies have evolved over the last 11 bil...

  4. Numerical Simulations of the Kolsky Compression Bar Test

    Energy Technology Data Exchange (ETDEWEB)

    Corona, Edmundo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-10-01

    The Kolsky compression bar, or split Hopkinson pressure bar (SHPB), is an ex- perimental apparatus used to obtain the stress-strain response of material specimens at strain rates in the order of 10 2 to 10 4 1/s. Its operation and associated data re- duction are based on principles of one-dimensional wave propagation in rods. Second order effects such as indentation of the bars by the specimen and wave dispersion in the bars, however, can significantly affect aspects of the measured material response. Finite element models of the experimental apparatus were used here to demonstrate these two effects. A procedure proposed by Safa and Gary (2010) to account for bar indentation was also evaluated and shown to improve the estimation of the strain in the bars significantly. The use of pulse shapers was also shown to alleviate the effects of wave dispersion. Combining the two can lead to more reliable results in Kolsky compression bar testing.

  5. Phosphoinositide 3-kinase γ affects LPS-induced disturbance of blood-brain barrier via lipid kinase-independent control of cAMP in microglial cells.

    Science.gov (United States)

    Frister, Adrian; Schmidt, Caroline; Schneble, Nadine; Brodhun, Michael; Gonnert, Falk A; Bauer, Michael; Hirsch, Emilio; Müller, Jörg P; Wetzker, Reinhard; Bauer, Reinhard

    2014-12-01

    The breakdown of the blood-brain barrier (BBB) is a key event in the development of sepsis-induced brain damage. BBB opening allows blood-born immune cells to enter the CNS to provoke a neuroinflammatory response. Abnormal expression and activation of matrix metalloproteinases (MMP) was shown to contribute to BBB opening. Using different mouse genotypes in a model of LPS-induced systemic inflammation, our present report reveals phosphoinositide 3-kinase γ (PI3Kγ) as a mediator of BBB deterioration and concomitant generation of MMP by microglia. Unexpectedly, microglia expressing lipid kinase-deficient mutant PI3Kγ exhibited similar MMP regulation as wild-type cells. Our data suggest kinase-independent control of cAMP phosphodiesterase activity by PI3Kγ as a crucial mediator of microglial cell activation, MMP expression and subsequent BBB deterioration. The results identify the suppressive effect of PI3Kγ on cAMP as a critical mediator of immune cell functions. PMID:25033932

  6. Valence band structure of the ZnO(1-bar 0-bar 1-bar -bar 0) surface studied by angle-resolved photoemission spectroscopy

    International Nuclear Information System (INIS)

    The electronic band structure of the ZnO(1-bar 0-bar 1-bar -bar 0) surface has been studied by angle-resolved photoemission spectroscopy utilizing synchrotron radiation. Photon-energy-dependent measurements and K- and O2-adsorption studies revealed that the O 2p dangling-bond state exists at 3.7eV below the Fermi level at the Γ-bar point. Polarization-dependent measurements show that the state has dominant contribution of the O 2px orbital (x is parallel to the (1-bar 2-bar -bar 1-bar 0) direction) at the Γ-bar point. It is found that the O 2p dangling-bond band lies within the projected bulk bands along the ΓX-bar -bar and-bar ΓX'-bar axes in the surface Brillouin zone. This result settles a controversial issue on the energetic position of the O 2p dangling-bond band, which has been in dispute among theoretical studies. The dispersion widths are found to be 0.8 and 0.5eV along the ΓX-bar -bar and-bar ΓX'-bar directions, respectively

  7. Quasinuclear N bar N states

    International Nuclear Information System (INIS)

    We present an interpretation of recent experimental results on nucleon-anti-nucleon annihilation reactions of the type N bar N → πX, which have yielded evidence for a new tensor meson AX (here called X2) with JπC(IG) = 2++(0+). The branching ratios for producing X2 from N bar N atomic states of orbital angular momentum L = 0,1, as well as its preference for decay into ρρ and ππ rather than K bar K channels, are consistent with the identifications of X2 as a 13P2-13F2 bound state of the N bar N potential. We suggest further key test of this interpretation. 21 refs

  8. Physical and metallurgical considerations of failures of soldered bars in bar attachment systems for implant overdentures: a review of the literature.

    Science.gov (United States)

    Waddell, J Neil; Payne, Alan G T; Swain, Michael V

    2006-10-01

    The purpose of this literature review was to identify the etiological factors of failure of soldered bars in bar attachment systems for removable implant overdentures. A search of MEDLINE using the key words "bar attachment systems" was performed of English language peer-reviewed journals published between 1975 and 2005. Clinical studies of implant overdentures with prosthodontic maintenance complications of bar attachment systems were identified to establish the perceived etiology of failure. A further search of MEDLINE using the key words "solder joint" was also performed of the fixed prosthodontic literature to identify specific factors affecting the strength, fatigue resistance, and quality of gold solder joints used for bar attachment systems. The first search on bar attachment systems produced evidence of low failure rates of interabutment bars, but higher failure rates of bars where distal cantilever extensions were used. There were no explanations or descriptions of the nature of those failures in the clinical studies reviewed. The second search on fixed prosthodontic literature identified multiple factors that could potentially relate to the failed solder joints with bar attachments. Two potential sites of failure in bar attachments with distal cantilevers were identified, and a simple estimate of the tensile stresses at the solder joints was performed. The values found are comparable to the fatigue failure stresses reported in the searched literature. PMID:17052473

  9. Electromagnetic Compressive Split Hopkinson Bar

    OpenAIRE

    Martins, P. A. F.; Rosa, P. A. R.; Silva, C. M. A.

    2008-01-01

    This paper proposes a new design for the compressive split Hopkinson bar that makes use of the intense pressure created in a transient magnetic field formed by the passage of a pulse of electric current through a series of coils. The proposed technology enables to characterize the behaviour of materials under high strain-rates with a small acceleration path length of the striker bar and, because propulsion is purely electromagnetic, the overall performance can be easily controlled and nearly ...

  10. Strength Degradation of Gfrp Bars

    OpenAIRE

    Bhise, Vikrant Sudhakar

    2002-01-01

    The primary objective of this research was to examine the strength degradation of Glass Fiber Reinforced Polymer (GFRP) bars at high temperature and alkalinity and determine if an Arrhenius type relationship can be used as a means of projecting life. The work done includes a thorough literature review, experiments and development of strength prediction models. The experimental work involves exposure of GFRP bars incased in cement mortar to lime-water solution at 30, 45 and 57°C. Overall 100 ...

  11. Multiprobe quantum spin Hall bars

    OpenAIRE

    Sanvito, Stefano

    2013-01-01

    PUBLISHED We analyze electron transport in multiprobe quantum spin Hall (QSH) bars using the B¨uttiker formalism and draw parallels with their quantum Hall (QH) counterparts. We find that in a QSH bar the measured resistance changes upon introducing side voltage probes, in contrast to the QH case. We also study four- and six-terminal geometries and derive the expressions for the resistances. For these our analysis is generalized from the single-channel to the multi-channel case...

  12. Barred disks in dense environments

    CERN Document Server

    Marinova, I; Heiderman, A; Barazza, F D; Gray, M E; Barden, M; Wolf, C; Peng, C Y; Bacon, D; Balogh, M; Bell, E F; Bohm, A; Caldwell, J A R; Haussler, B; Heymans, C; Jahnke, K; van Kampen, E; Koposov, S; Lane, K; McIntosh, D H; Meisenheimer, K; Rix, H -W; Sanchez, S F; Taylor, A; Wisotzki, L; Zheng, X

    2010-01-01

    We investigate the properties of bright (MV <= -18) barred and unbarred disks in the Abell 901/902 cluster system at z~0.165 with the STAGES HST ACS survey. To identify and characterize bars, we use ellipse-fitting. We use visual classification, a Sersic cut, and a color cut to select disk galaxies, and find that the latter two methods miss 31% and 51%, respectively of disk galaxies identified through visual classification. This underscores the importance of carefully selecting the disk sample in cluster environments. However, we find that the global optical bar fraction in the clusters is ~30% regardless of the method of disk selection. We study the relationship of the optical bar fraction to host galaxy properties, and find that the optical bar fraction depends strongly on the luminosity of the galaxy and whether it hosts a prominent bulge or is bulgeless. Within a given absolute magnitude bin, the optical bar fraction increases for galaxies with no significant bulge component. Within each morphological ...

  13. Bar Formation from Galaxy Flybys

    CERN Document Server

    Lang, Meagan; Sinha, Manodeep

    2014-01-01

    Recently, both simulations and observations have revealed that flybys - fast, one-time interactions between two galaxy halos - are surprisingly common, nearing/comparable to galaxy mergers. Since these are rapid, transient events with the closest approach well outside the galaxy disk, it is unclear if flybys can transform the galaxy in a lasting way. We conduct collisionless N-body simulations of three co-planer flyby interactions between pure-disk galaxies to take a first look at the effects flybys have on disk structure, with particular focus on stellar bar formation. We find that some flybys are capable of inciting a bar with bars forming in both galaxies during our 1:1 interaction and in the secondary during our 10:1 interaction. The bars formed have ellipticities >0.5, sizes on the order of the host disk's scale length, and persist to the end of our simulations, ~5 Gyr after pericenter. The ability of flybys to incite bar formation implies that many processes associated with secular bar evolution may be ...

  14. Changes in lipid metabolism and β-adrenergic response of adipose tissues of periparturient dairy cows affected by an energy-dense diet and nicotinic acid supplementation.

    Science.gov (United States)

    Kenéz, Á; Tienken, R; Locher, L; Meyer, U; Rizk, A; Rehage, J; Dänicke, S; Huber, K

    2015-08-01

    Dairy cattle will mobilize large amounts of body fat during early lactation as an effect of decreased lipogenesis and increased lipolysis. Regulation of lipid metabolism involves fatty acid synthesis from acetate and β-adrenergic-stimulated phosphorylation of hormone-sensitive lipase (HSL) and perilipin in adipocytes. Although basic mechanisms of mobilizing fat storage in transition cows are understood, we lack a sufficiently detailed understanding to declare the exact regulatory network of these in a broad range of dairy cattle. The objective of the present study was to quantify 1) protein abundance of fatty acid synthase (FAS), 2) extent of phosphorylation of HSL and perilipin in vivo, and 3) β-adrenergic stimulated lipolytic response of adipose tissues in vitro at different stages of the periparturient period. We fed 20 German Holstein cows an energy-dense or an energetically adequate diet prepartum and 0 or 24 g/d nicotinic acid (NA) supplementation. Biopsy samples of subcutaneous and retroperitoneal adipose tissue were obtained at d 42 prepartum (d -42) and at d 1, 21, and 100 postpartum (d +1, d +21, d +100, respectively). To assess β-adrenergic response, tissue samples were incubated with 1 μ isoproterenol for 90 min at 37°C. The NEFA and glycerol release, as well as HSL and perilipin phosphorylation, was measured as indicators of in vitro stimulated lipolysis. In addition, protein expression of FAS and extent of HSL and perilipin phosphorylation were measured in fresh, nonincubated samples. There was no effect of dietary energy density or NA on the observed variables. The extent of HSL and perilipin phosphorylation under isoproterenol stimulation was strongly correlated with the release of NEFA and glycerol, consistent with the functional link between β-adrenergic-stimulated protein phosphorylation and lipolysis. In the nonincubated samples, FAS protein expression was decreased at d +1 and d +21, whereas HSL and perilipin phosphorylation increased

  15. A diet rich in conjugated linoleic acid and butter increases lipid peroxidation but does not affect atherosclerotic, inflammatory, or diabetic risk markers in healthy young men

    DEFF Research Database (Denmark)

    Raff, Marianne; Tholstrup, Tine; Basu, Samar;

    2008-01-01

    Intake of conjugated linoleic acid (CLA) has been demonstrated to beneficially affect risk markers of atherosclerosis and diabetes in rats. CLA is naturally found in milk fat, especially from cows fed a diet high in oleic acid, and increased CLA intake can occur concomitantly with increased milk...... oil, a mixture of 39.4% cis9, trans11 and 38.5% trans10, cis12) or of control fat with a low content of CLA in a 5-wk double-blind, randomized, parallel intervention study. We collected blood and urine before and after the intervention. The fatty acid composition of plasma triacylglycerol, cholesterol...

  16. A note on the B*B-bar, B*B-bar*, D*D-bar, D*D-bar* molecular states

    International Nuclear Information System (INIS)

    In the framework of the one-boson-exchange model, we have performed an extensive study of the possible B*B-bar, B*B-bar*, D*D-bar, D*D-bar* molecular states with various quantum numbers after considering the S-wave and D-wave mixing. We also discuss the possible experimental research of these interesting states. (authors)

  17. Optimization of steel bar manufacturing process using six sigma

    Science.gov (United States)

    Naeem, Khawar; Ullah, Misbah; Tariq, Adnan; Maqsood, Shahid; Akhtar, Rehman; Nawaz, Rashid; Hussain, Iftikhar

    2016-03-01

    Optimization of a manufacturing process results in higher productivity and reduced wastes. Production parameters of a local steel bar manufacturing industry of Pakistan is optimized by using six Sigma-Define, measure, analyze, improve, and controlmethodology. Production data is collected and analyzed. After analysis, experimental design result is used to identify significant factors affecting process performance. The significant factors are controlled to optimized level using two-level factorial design method. A regression model is developed that helps in the estimation of response under multi variable input values. Model is tested, verified, and validated by using industrial data collected at a local steel bar manufacturing industry of Peshawar(Khyber Pakhtunkhwa, Pakistan). The sigma level of the manufacturing process is improved to 4.01 from 3.58. The novelty of the research is the identification of the significant factors along with the optimum levels that affects the process yield, and the methodology to optimize the steel bar manufacturing process.

  18. Optimization of Steel Bar Manufacturing Process Using Six Sigma

    Institute of Scientific and Technical Information of China (English)

    NAEEM Khawar; ULLAH Misbah; TARIQ Adnan; MAQSOOD Shahid; AKHTAR Rehman; NAWAZ Rashid; HUSSAIN Iftikhar

    2016-01-01

    Optimization of a manufacturing process results in higher productivity and reduced wastes. Production parameters of a local steel bar manufacturing industry of Pakistan is optimized by using six Sigma-Define, measure, analyze, improve, and control- methodology. Production data is collected and analyzed. After analysis, experimental design result is used to identify significant factors affecting process performance. The significant factors are controlled to optimized level using two-level factorial design method. A regression model is developed that helps in the estimation of response under multi variable input values. Model is tested, verified, and validated by using industrial data collected at a local steel bar manufacturing industry of Peshawar(Khyber Pakhtunkhwa, Pakistan). The sigma level of the manufacturing process is improved to 4.01 from 3.58. The novelty of the research is the identification of the significant factors along with the optimum levels that affects the process yield, and the methodology to optimize the steel bar manufacturing process.

  19. Modulation transfer function of bar code scanning

    Science.gov (United States)

    Tang, Hong; Milster, Tom D.

    1998-09-01

    Bar code scanners are ubiquitous in supermarkets. As a bar code is passed over a scanner, a laser beam scans across the bar code. The scattered light is modulated by the reflectivity of the bars and spaces of the bar code. The bar code scanning process can be described as a 1D convolution of the scanning laser profile and the bar code reflectivity function. The modulation transfer function (MTF) of bar code scanning is the Fourier transform of the marginal profile of the laser beam. The properties of the MTF of bar code scanning is similar to that of an incoherent imaging system. Measurements of the MTF of bar code scanning at one focus position are presented. The experimental results are then discussed.

  20. Gas flow in barred potentials II. Bar Driven Spiral Arms

    CERN Document Server

    Sormani, Mattia C; Magorrian, John

    2015-01-01

    Spiral arms that emerge from the ends of a galactic bar are important in interpreting observations of our and external galaxies. It is therefore important to understand the physical mechanism that causes them. We find that these spiral arms can be understood as kinematic density waves generated by librations around underlying ballistic closed orbits. This is even true in the case of a strong bar, provided the librations are around the appropriate closed orbits and not around the circular orbits that form the basis of the epicycle approximation. An important consequence is that it is a potential's orbital structure that determines whether a bar should be classified as weak or strong, and not crude estimates of the potential's deviation from axisymmetry.

  1. Application of roasted rice bran in cereal bars

    Directory of Open Access Journals (Sweden)

    Marina Costa Garcia

    2012-12-01

    Full Text Available The objective of this study was to evaluate the viability of using microwave-roasted rice bran as an ingredient in high-fiber cereal bars to obtain a product with good acceptability. The influence of the rice flakes, corn flakes, and roasted rice bran levels on the physical and chemical characteristics of the cereal bars was studied. The overall acceptability of three selected formulations was also evaluated. An increase in the roasted rice bran level in the formulation reduced the force of rupture and water activity, resulted in intermediate density, and caused darkening of the bars. The contents of lipid and total dietary fiber were higher in the formulation with the highest rice bran content, which was therefore classified as functional food. The formulation containing 0.34; 0.32; and 0.34 roasted rice bran, rice flakes, and corn flakes, respectively, seemed to be the best outcome. Cereal bars with roasted rice bran levels between 10 and 20% were accepted by consumers.

  2. ANATOMY OF THE BAR INSTABILITY IN CUSPY DARK MATTER HALOS

    International Nuclear Information System (INIS)

    We examine the bar instability in galactic models with an exponential disk and a cuspy dark matter (DM) halo with a Navarro-Frenk-White cosmological density profile. The equilibrium models are constructed from a three-integral composite distribution function but subject to the bar instability. We generate a sequence of models with a range of mass resolution from 1.8 K to 18 M particles in the disk and 10 K to 100 M particles in the halo along with a multimass model with an effective resolution of ∼1010 particles. We describe how mass resolution affects the bar instability, including its linear growth phase, the buckling instability, pattern speed decay through the resonant transfer of angular momentum to the DM halo, and the possible destruction of the halo cusp. Our higher resolution simulations show a converging spectrum of discrete resonance interactions between the bar and DM halo orbits. As the pattern speed decays, orbital resonances sweep through most of the DM halo phase space and widely distribute angular momentum among the halo particles. The halo does not develop a flat density core and preserves the cusp, except in the region dominated by gravitational softening. The formation of the bar increases the central stellar density and the DM is compressed adiabatically increasing the halo central density by 1.7 times. Overall, the evolution of the bar displays a convergent behavior for halo particle numbers between 1 M and 10 M particles, when comparing bar growth, pattern speed evolution, the DM halo density profile and a nonlinear analysis of the orbital resonances. Higher resolution simulations clearly illustrate the importance of discrete resonances in transporting the angular momentum from the bar to the halo.

  3. Lipid droplets, lipophagy, and beyond.

    Science.gov (United States)

    Wang, Chao-Wen

    2016-08-01

    Lipids are essential components for life. Their various structural and physical properties influence diverse cellular processes and, thereby, human health. Lipids are not genetically encoded but are synthesized and modified by complex metabolic pathways, supplying energy, membranes, signaling molecules, and hormones to affect growth, physiology, and response to environmental insults. Lipid homeostasis is crucial, such that excess fatty acids (FAs) can be harmful to cells. To prevent such lipotoxicity, cells convert excess FAs into neutral lipids for storage in organelles called lipid droplets (LDs). These organelles do not simply manage lipid storage and metabolism but also are involved in protein quality management, pathogenesis, immune responses, and, potentially, neurodegeneration. In recent years, a major trend in LD biology has centered around the physiology of lipid mobilization via lipophagy of fat stored within LDs. This review summarizes key findings in LD biology and lipophagy, offering novel insights into this rapidly growing field. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon. PMID:26713677

  4. Lipid Use and Misuse by the Heart.

    Science.gov (United States)

    Schulze, P Christian; Drosatos, Konstantinos; Goldberg, Ira J

    2016-05-27

    The heart utilizes large amounts of fatty acids as energy providing substrates. The physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids. Several processes that affect cardiac function, including ischemia, obesity, diabetes mellitus, sepsis, and most forms of heart failure lead to altered fatty acid oxidation and often also to the accumulation of lipids. There is now mounting evidence associating certain species of these lipids with cardiac lipotoxicity and subsequent myocardial dysfunction. Experimental and clinical data are discussed and paths to reduction of toxic lipids as a means to improve cardiac function are suggested. PMID:27230639

  5. Downstream-migrating fluvial point bars in the rock record

    Science.gov (United States)

    Ghinassi, Massimiliano; Ielpi, Alessandro; Aldinucci, Mauro; Fustic, Milovan

    2016-04-01

    Classical models developed for ancient fluvial point bars are based on the assumption that meander bends invariably increase their radius as meander-bend apices migrate in a direction transverse to the channel-belt axis (i.e., meander bend expansion). However, many modern meandering rivers are also characterized by down-valley migration of the bend apex, a mechanism that takes place without a significant change in meander radius and wavelength. Downstream-migrating fluvial point bars (DMFPB) are the dominant architectural element of these types of meander belts. Yet they are poorly known from ancient fluvial-channel belts, since their disambiguation from expansional point bars often requires fully-3D perspectives. This study aims to review DMFPB deposits spanning in age from Devonian to Holocene, and to discuss their main architectural and sedimentological features from published outcrop, borehole and 3D-seismic datasets. Fluvial successions hosting DMFPB mainly accumulated in low accommodation conditions, where channel belts were affected by different degrees of morphological (e.g., valleys) or tectonic (e.g., axial drainage of shortening basins) confinement. In confined settings, bends migrate downstream along the erosion-resistant valley flanks and little or no floodplain deposits are preserved. Progressive floor aggradation (e.g., valley filling) allow meander belts with DMFPB to decrease their degree of confinement. In less confined settings, meander bends migrate downstream mainly after impinging against older, erosion-resistant channel fill mud. By contrast, tectonic confinement is commonly associated with uplifted alluvial plains that prevented meander-bend expansion, in turn triggering downstream translation. At the scale of individual point bars, translational morphodynamics promote the preservation of downstream-bar deposits, whereas the coarser-grained upstream and central beds are less frequently preserved. However, enhanced preservation of upstream-bar

  6. Exogenous lipid pneumonia

    International Nuclear Information System (INIS)

    Exogenous lipid pneumonia (ELP) is caused by the aspiration of animal, vegetal or, more often, mineral oils. Even though it may also be acute, ELP is most frequently a chronic disease, affecting people with predisposing factors, such as neuromuscular disorders, structural abnormalities and so on; very often exogenous lipid pneumonia is found in tracheotomized patients. The pathology of lipid pneumonia is a chronic inflammatory process evolving in foreign-body-like reaction, and eventually in ''end-stage lung'' condition. Clinically, most patients are asymptomatic; few cases only present with cough, dyspnea and chest pain. Eight cases of ELP, studied over the past 3 years, are described in this paper. All the patients were examined by chest radiographs and standard tomograms; 3 patients underwent CT. X-ray features were mono/bilateral consolidation of the lower zones, with air bronchogram and variable reduction in volume. CT density was not specific for fat tissue. In all cases the diagnosis was confirmed at biopsy. In 5 patients, followed for at least one year, clinical-radiological features showed no change. Thus, complications of ELP (especially malignant evolution) could be excluded. The authors conclude that lipid pneumonia must be considered in differential diagnosis of patients with history of usage of oils and compatible X-ray findings. The usefulness of an accurate follow-up is stressed

  7. College Students' Exposure to Tobacco Marketing in Nightclubs and Bars

    Science.gov (United States)

    Ridner, S. Lee; Myers, John A.; Hahn, Ellen J.; Ciszewski, Tiffany N.

    2010-01-01

    Objective: To examine whether a college student's exposure to tobacco marketing in nightclubs and bars was affected by the presence of a smoke-free law. Participants: A random sample (N = 478) of students participated in the survey (no smoke-free law, n = 240; smoke-free law, n = 238). The analysis was limited to students who reported being in…

  8. Dynamically possible pattern speeds of double bars

    CERN Document Server

    Maciejewski, Witold

    2009-01-01

    The method to study oscillating potentials of double bars, based on invariant loops, is introduced here in a new way, intended to be more intelligible. Using this method, I show how the orbital structure of a double-barred galaxy (nested bars) changes with the variation of nuclear bar's pattern speed. Not all pattern speeds are allowed when the inner bar rotates in the same direction as the outer bar. Below certain minimum pattern speed orbital support for the inner bar abruptly disappears, while high values of this speed lead to loops that are increasingly round. For values between these two extremes, loops supporting the inner bar extend further out as its pattern speed decreases, and they become more eccentric and pulsate more. These findings do not apply to counter-rotating inner bars.

  9. Isolipidic diets differing in their essential fatty acid profiles affect the deposition of unsaturated neutral lipids in the intestine, liver and vascular system of Senegalese sole larvae and early juveniles

    OpenAIRE

    Boglino, A.; Gisbert, E.; Darias, Maria Jose; Estevez, A; Andree, K. B.; Sarasquete, C; Ortiz-Delgado, J.B.

    2012-01-01

    How lipid content and composition in the diet is utilized by the various organs and tissues of fish is reflected in their structure, such as the intestine through which dietary lipids are digested and absorbed, the vascular system which is involved in their transport, and the liver where lipids are stored and metabolized. However, no study has been conducted to compare the effect of different diets containing different levels of highly unsaturated fatty acids (HUFA) and essential fatty acids ...

  10. Bars in the Barkor Street

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In daytime,the Barkor Street is bustling with tourists,pious pilgrims and merchants crowded together.Only when darkness falls does the street become tranquil.Nevertheless,the area surrounding the Barkor Street(from Tibetan Hospital compound extending to east Beijing Road)is then revived by various kinds of bars.

  11. Bars in Beijing Old Town

    Institute of Scientific and Technical Information of China (English)

    GUANYUNZHANG

    2003-01-01

    It's seven pm on a summer's evening by Shichahao Lake,central Beijing.A welcome breeze whispers across the lake,and the ruddy vestiges of sunset linger on roofs and treetops.A low hum emanates from bars on the lakeshore packed with young people chatting,drinking and generally

  12. Demographic response of northern spotted owls to barred owl removal

    Science.gov (United States)

    Diller, V. Lowell; Hamm, Keith A; Early, Desiree A; Lamphear, David W; Katie Dugger; Yackulic, Charles B.; Schwarz, Carl J.; Carlson, Peter C.; McDonald, Trent L.

    2016-01-01

    Federally listed as threatened in 1990 primarily because of habitat loss, the northern spotted owl (Strix occidentalis caurina) has continued to decline despite conservation efforts resulting in forested habitat being reserved throughout its range. Recently, there is growing evidence the congeneric invasive barred owl (Strix varia) may be responsible for the continued decline primarily by excluding spotted owls from their preferred habitat. We used a long-term demographic study for spotted owls in coastal northern California as the basis for a pilot barred owl removal experiment. Our demography study used capture–recapture, reproductive output, and territory occupancy data collected from 1990 to 2013 to evaluate trends in vital rates and populations. We used a classic before-after-control-impact (BACI) experimental design to investigate the demographic response of northern spotted owls to the lethal removal of barred owls. According to the best 2-species dynamic occupancy model, there was no evidence of differences in barred or northern spotted owl occupancy prior to the initiation of the treatment (barred owl removal). After treatment, barred owl occupancy was lower in the treated relative to the untreated areas and spotted owl occupancy was higher relative to the untreated areas. Barred owl removal decreased spotted owl territory extinction rates but did not affect territory colonization rates. As a result, spotted owl occupancy increased in the treated area and continued to decline in the untreated areas. Prior to and after barred owl removal, there was no evidence that average fecundity differed on the 2 study areas. However, the greater number of occupied spotted owl sites on the treated areas resulted in greater productivity in the treated areas based on empirical counts of fledged young. Prior to removal, survival was declining at a rate of approximately 0.2% per year for treated and untreated areas. Following treatment, estimated survival was 0.859 for

  13. Galaxy Zoo: Observing Secular Evolution Through Bars

    CERN Document Server

    Cheung, Edmond; Masters, Karen L; Nichol, Robert C; Bosma, A; Bell, Eric F; Faber, S M; Koo, David C; Lintott, Chris; Melvin, Thomas; Schawinski, Kevin; Skibba, Ramin A; Willett, Kyle W

    2013-01-01

    Observations have shown that there is a connection between the presence of a bar and the properties of a galaxy. In a parallel effort, simulations have shown that this connection is consistent with the theory of bar-driven secular evolution. But observational evidence of bar-driven secular evolution has been sparse. In this paper, we use the Galaxy Zoo 2 dataset to look for evidence of this secular evolution. Our sample consists of 13,295 disk galaxies, with an overall bar fraction of 23.6 +/- 0.4%, of which 1,154 barred galaxies also have bar length measurements. These samples are the largest ever used to study the role of bars in disk galaxy evolution. We characterize bars by the bar likelihood, the likelihood a bar is present in a given galaxy, and the bar length. These two bar properties show interesting correlations with the specific star formation rate and the inner central structure of galaxies. Comparing these observations to state-of-the-art simulations of bar evolution, which include live halos and ...

  14. Characteristics of lipids and their feeding value in swine diets

    OpenAIRE

    Kerr, Brian J; Kellner, Trey A.; Shurson, Gerald C.

    2015-01-01

    In livestock diets, energy is one of the most expensive nutritional components of feed formulation. Because lipids are a concentrated energy source, inclusion of lipids are known to affect growth rate and feed efficiency, but are also known to affect diet palatability, feed dustiness, and pellet quality. In reviewing the literature, the majority of research studies conducted on the subject of lipids have focused mainly on the effects of feeding presumably high quality lipids on growth perform...

  15. Predicting vertical jump height from bar velocity.

    Science.gov (United States)

    García-Ramos, Amador; Štirn, Igor; Padial, Paulino; Argüelles-Cienfuegos, Javier; De la Fuente, Blanca; Strojnik, Vojko; Feriche, Belén

    2015-06-01

    The objective of the study was to assess the use of maximum (Vmax) and final propulsive phase (FPV) bar velocity to predict jump height in the weighted jump squat. FPV was defined as the velocity reached just before bar acceleration was lower than gravity (-9.81 m·s(-2)). Vertical jump height was calculated from the take-off velocity (Vtake-off) provided by a force platform. Thirty swimmers belonging to the National Slovenian swimming team performed a jump squat incremental loading test, lifting 25%, 50%, 75% and 100% of body weight in a Smith machine. Jump performance was simultaneously monitored using an AMTI portable force platform and a linear velocity transducer attached to the barbell. Simple linear regression was used to estimate jump height from the Vmax and FPV recorded by the linear velocity transducer. Vmax (y = 16.577x - 16.384) was able to explain 93% of jump height variance with a standard error of the estimate of 1.47 cm. FPV (y = 12.828x - 6.504) was able to explain 91% of jump height variance with a standard error of the estimate of 1.66 cm. Despite that both variables resulted to be good predictors, heteroscedasticity in the differences between FPV and Vtake-off was observed (r(2) = 0.307), while the differences between Vmax and Vtake-off were homogenously distributed (r(2) = 0.071). These results suggest that Vmax is a valid tool for estimating vertical jump height in a loaded jump squat test performed in a Smith machine. Key pointsVertical jump height in the loaded jump squat can be estimated with acceptable precision from the maximum bar velocity recorded by a linear velocity transducer.The relationship between the point at which bar acceleration is less than -9.81 m·s(-2) and the real take-off is affected by the velocity of movement.Mean propulsive velocity recorded by a linear velocity transducer does not appear to be optimal to monitor ballistic exercise performance. PMID:25983572

  16. Bar, Orliac-de-Bar, Beaumont, Saint–Augustin, Ussel

    OpenAIRE

    Simonnot, Bernard

    2013-01-01

    Identifiant de l'opération archéologique : 2735 Date de l'opération : 2007 (PR) Inventeur(s) : Simonnot Bernard (BEN) La prospection sur les communes de Bar, Orliac-de-Bar, Beaumont et Saint-Augustin n’ayant pas donné pour le moment de nouveaux résultats satisfaisants, une reprise sera nécessaire lors de la prochaine campagne. Ceux découverts récemment demandent une étude plus approfondie. Cette année, la prospection s’est limitée à la partie ouest de la commune d’Ussel, dans la zone de renc...

  17. Secular Damping of Stellar Bars in Spinning Dark Matter Halos

    CERN Document Server

    Long, Stacy; Heller, Clayton

    2014-01-01

    We demonstrate that growth of stellar bars in spinning dark matter halos is heavily suppressed in the secular phase of evolution, using numerical simulations of isolated galaxies. In a representative set of models, we show that for values of the cosmological spin parameter lambda > 0.03, bar growth (in strength and size) becomes increasingly quenched. Furthermore, slowdown of bar pattern speed weakens substantially with increasing `lambda,' until it ceases completely. The terminal structure of bars is affected as well, including extent and shape of their boxy/peanut bulges. The essence of this effect lies in the modified angular momentum exchange between the disk and the halo facilitated by the bar. For the first time we have demonstrated that a dark matter halo can emit and not purely absorb angular momentum. Although the halo as a whole is not found to emit, the net transfer of angular momentum from the disk to the halo is significantly reduced or completely eliminated. The paradigm shift implies that the a...

  18. Going Smokefree Matters - Bars and Restaurants Infographic

    Data.gov (United States)

    U.S. Department of Health & Human Services — Explore the Going Smokefree Matters – Bars and Restaurants Infographic which outlines key facts related to the effects of secondhand smoke exposure in bars and...

  19. Bar instabilities in Coma cluster galaxies

    International Nuclear Information System (INIS)

    The radial distribution of bar versus nonbar galaxies within the Coma cluster shows that a significantly larger fraction of bar galaxies are members of the cluster core. This result can be used either to estimate the time scale for the decay of bar instabilities or to argue that galaxies in the core of Coma are confined within the core

  20. Bar code instrumentation for nuclear safeguards

    International Nuclear Information System (INIS)

    This paper presents a brief overview of the basic principles of bar codes and the equipment used to make and to read bar code labels, and a summary of some of the more important factors that need to be considered in integrating bar codes into an information system

  1. One year of smokefree bars and restaurants in New Zealand: Impacts and responses

    Directory of Open Access Journals (Sweden)

    Wilson Nick

    2006-03-01

    Full Text Available Abstract Background New Zealand introduced a smokefree bars and restaurants policy in December 2004. We reviewed the data available at December 2005 on the main public health, societal and political impacts and responses within New Zealand to the new law. Methods Data were collected from publicly available survey reports, and from government departments and interviews. This included data on smoking in bars, attitudes to smokefree bars, bar patronage, socially cued smoking, and perceived rights to smokefree workplaces. Results The proportion of surveyed bars with smoking occurring decreased from 95% to 3% during July 2004 – April 2005. Between 2004 and 2005, public support for smokefree bars rose from 56% to 69%. In the same period, support for the rights of bar workers to have smokefree workplaces rose from 81% to 91%. During the first ten months of the smokefree bars policy, there were only 196 complaints to officials about smoking in the over 9900 licensed premises. The proportion of smokers who reported that they smoked more than normal at bars, nightclubs, casinos and cafés halved between 2004 and 2005 (from 58% to 29%. Seasonally adjusted sales in bars and clubs changed little (0.6% increase between the first three quarters of 2004 and of 2005, while café and restaurant sales increased by 9.3% in the same period. Both changes continued existing trends. Compared to the same period in 2004, average employment during the first three quarters of 2005 was up 24% for 'pubs, taverns and bars', up 9% for cafés/restaurants, and down 8% for clubs (though employment in 'pubs, taverns and bars' may have been affected by unusually high patronage around a major sports-series. The proportion of bar managers who approved of smokefree bars increased from 44% to 60% between November 2004 and May 2005. Bar managers also reported increased agreement with the rights of bar workers and patrons to smokefree environments. The main reported concerns of the

  2. WRP/srGAP3 Facilitates the Initiation of Spine Development by an Inverse F-BAR Domain, and Its Loss Impairs Long-Term Memory

    OpenAIRE

    Carlson, Benjamin R.; Lloyd, Krissey E; Kruszewski, Allison; Kim, Il-Hwan; Rodriguiz, Ramona M.; Heindel, Clifford; Faytell, Marika; Dudek, Serena M.; Wetsel, William C.; Soderling, Scott H.

    2011-01-01

    The WAVE-associated Rac GAP, WRP, is thought to regulate key aspects of synapse development and function and may be linked to mental retardation in humans. WRP contains a newly described inverse F-BAR (IF-BAR) domain of unknown function. Our studies show that this domain senses/facilitates outward protrusions analogous to filopodia and that the molecular basis for this is likely explained by a convex lipid-binding surface on the WRP IF-BAR domain. In dendrites the IF-BAR domain of WRP forms a...

  3. Higher-order assemblies of BAR domain proteins for shaping membranes.

    Science.gov (United States)

    Suetsugu, Shiro

    2016-06-01

    Most cellular organelles contain lipid bilayer membranes. The earliest characterization of cellular organelles was performed by electron microscopy observation of such membranes. However, the precise mechanisms for shaping the membrane in particular subcellular organelles is poorly understood. Classically, the overall cellular shape, i.e. the shape of the plasma membrane, was thought to be governed by the reorganization of cytoskeletal components such as actin and microtubules. The plasma membrane contains various submicron structures such as clathrin-coated pits, caveolae, filopodia and lamellipodia. These subcellular structures are either invaginations or protrusions and are associated with the cytoskeleton. Therefore, it could be hypothesized that there are membrane-binding proteins that cooperates with cytoskeleton in shaping of plasma membrane organelles. Proteins with the Bin-Amphiphysin-Rvs (BAR) domain connect a variety of membrane shapes to actin filaments. The BAR domains themselves bend the membranes by their rigidity and then mold the membranes into tubules through their assembly as spiral polymers, which are thought to be involved in the various submicron structures. Membrane tubulation by polymeric assembly of the BAR domains is supposed to be regulated by binding proteins, binding lipids and the mechanical properties of the membrane. This review gives an overview of BAR protein assembly, describes the significance of the assembly and discusses how to study the assembly in the context of membrane and cellular morphology. The technical problems encountered in microscopic observation of BAR domain assembly are also discussed. PMID:26884618

  4. Preparation of a cereal bar containing bocaiuva: physical, nutritional, microbiological and sensory evaluation

    Directory of Open Access Journals (Sweden)

    Cláudia Leite Munhoz

    2014-02-01

    Full Text Available Regional fruit have been increasingly used in recent years in the preparation of foodstuffs because besides promoting the biome preservation, it is obtained differentiated and value-added products. This study aimed to prepare cereal bars containing pulp and kernel of bocaiuva and determine the nutritional quality, assess the acceptability, and microbiological quality. Two formulations of cereal bar were prepared with pulp dehydrated by osmoconvection and kernel of bocaiuva. The formulations were analyzed as for the texture, color analysis, proximate composition, fatty acids profile, mineral, microbiology and sensory evaluation. Cereal bars presented on average, in g 100 g-1, 4.83 moisture, 8.01 protein, 12.93 lipids, 1.30 ash, 53.75 total carbohydrate, 19.78 fiber and 363.41 kcal 100 g-1 total caloric value. Bars represented a source of calcium and iron and had a high content of oleic acid, average of 20 g 100 g-1 total lipids. In the microbiological evaluation, cereal bars have met the standards set by the legislation, being suitable for consumption. As for the attributes evaluated in the sensory analysis, all showed mean values above 6, considered acceptable for consumption. The use of bocaiuva may contribute to highlight differentiated taste and appearance, emphasizing the use of native fruits in the preparation of new products.

  5. Galaxy Zoo: Observing secular evolution through bars

    Energy Technology Data Exchange (ETDEWEB)

    Cheung, Edmond; Faber, S. M.; Koo, David C. [Department of Astronomy and Astrophysics, 1156 High Street, University of California, Santa Cruz, CA 95064 (United States); Athanassoula, E.; Bosma, A. [Aix Marseille Université, CNRS, LAM (Laboratoire d' Astrophysique de Marseille) UMR 7326, F-13388, Marseille (France); Masters, Karen L.; Nichol, Robert C.; Melvin, Thomas [Institute of Cosmology and Gravitation, University of Portsmouth, Dennis Sciama Building, Portsmouth, PO1 3FX (United Kingdom); Bell, Eric F. [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48109 (United States); Lintott, Chris [Oxford Astrophysics, Department of Physics, University of Oxford, Denys Wilkinson Building, Keble Road, Oxford OX1 3RH (United Kingdom); Schawinski, Kevin [Institute for Astronomy, Department of Physics, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093 Zurich (Switzerland); Skibba, Ramin A. [Center for Astrophysics and Space Sciences, Department of Physics, 9500 Gilman Drive, University of California, San Diego, CA 92093 (United States); Willett, Kyle W., E-mail: ec2250@gmail.com [School of Physics and Astronomy, University of Minnesota, MN 55455 (United States)

    2013-12-20

    In this paper, we use the Galaxy Zoo 2 data set to study the behavior of bars in disk galaxies as a function of specific star formation rate (SSFR) and bulge prominence. Our sample consists of 13,295 disk galaxies, with an overall (strong) bar fraction of 23.6% ± 0.4%, of which 1154 barred galaxies also have bar length (BL) measurements. These samples are the largest ever used to study the role of bars in galaxy evolution. We find that the likelihood of a galaxy hosting a bar is anticorrelated with SSFR, regardless of stellar mass or bulge prominence. We find that the trends of bar likelihood and BL with bulge prominence are bimodal with SSFR. We interpret these observations using state-of-the-art simulations of bar evolution that include live halos and the effects of gas and star formation. We suggest our observed trends of bar likelihood with SSFR are driven by the gas fraction of the disks, a factor demonstrated to significantly retard both bar formation and evolution in models. We interpret the bimodal relationship between bulge prominence and bar properties as being due to the complicated effects of classical bulges and central mass concentrations on bar evolution and also to the growth of disky pseudobulges by bar evolution. These results represent empirical evidence for secular evolution driven by bars in disk galaxies. This work suggests that bars are not stagnant structures within disk galaxies but are a critical evolutionary driver of their host galaxies in the local universe (z < 1).

  6. Galaxy Zoo: Observing secular evolution through bars

    International Nuclear Information System (INIS)

    In this paper, we use the Galaxy Zoo 2 data set to study the behavior of bars in disk galaxies as a function of specific star formation rate (SSFR) and bulge prominence. Our sample consists of 13,295 disk galaxies, with an overall (strong) bar fraction of 23.6% ± 0.4%, of which 1154 barred galaxies also have bar length (BL) measurements. These samples are the largest ever used to study the role of bars in galaxy evolution. We find that the likelihood of a galaxy hosting a bar is anticorrelated with SSFR, regardless of stellar mass or bulge prominence. We find that the trends of bar likelihood and BL with bulge prominence are bimodal with SSFR. We interpret these observations using state-of-the-art simulations of bar evolution that include live halos and the effects of gas and star formation. We suggest our observed trends of bar likelihood with SSFR are driven by the gas fraction of the disks, a factor demonstrated to significantly retard both bar formation and evolution in models. We interpret the bimodal relationship between bulge prominence and bar properties as being due to the complicated effects of classical bulges and central mass concentrations on bar evolution and also to the growth of disky pseudobulges by bar evolution. These results represent empirical evidence for secular evolution driven by bars in disk galaxies. This work suggests that bars are not stagnant structures within disk galaxies but are a critical evolutionary driver of their host galaxies in the local universe (z < 1).

  7. Amylose content in rice (Oryza sativa affects performance, glycemic and lipidic metabolism in rats Teor de amilose do arroz (Oryza sativa afeta o desempenho, metabolismo glicêmico e lipídico em ratos

    Directory of Open Access Journals (Sweden)

    Cristiane Casagrande Denardin

    2012-02-01

    Full Text Available This research aimed at evaluating the effect of diets with high, intermediate and low amylose content of rice on performance, glycemic and lipidic metabolism in rats. Male Wistar rats were fed diets with grains of cooked rice of the cultivars 'IRGA 417', 'IRGA 416' and 'MOCHI' with high, intermediate and low amylose content, respectively. Wet and dry fecal production and serum HDL cholesterol were not affected by amylose content. The animals in the treatments with high amylose content ('IRGA 417' presented lower feed intake, body weight gain and apparent digestibility, higher fecal water content and nitrogen excretion, reduced fecal pH, lower postprandial blood glucose response, serum total cholesterol and triglycerides levels and pancreas weight, and higher fasting serum glucose concentration and liver weight. Amylose:amylopectin ratio significantly affects rice starch digestion in the gastrointestinal tract, affecting some biologically relevant parameters.O objetivo deste trabalho foi avaliar o efeito de dietas com alto, intermediário e baixo teor de amilose sobre o desempenho, metabolismo glicêmico e lipídico em ratos. Foram utilizados ratos machos Wistar alimentados com rações experimentais elaboradas com grãos de arroz cozido das cultivares 'IRGA 417', 'IRGA 416' e 'MOCHI' com alto, intermediário e baixo teores de amilose, respectivamente. A produção de fezes úmidas e secas e colesterol HDL não foram afetados pelo teor de amilose dos grãos. Os animais submetidos ao tratamento com alto teor de amilose (IRGA 417 apresentaram menores consumo, ganho de peso e digestibilidade aparente, maiores umidade nas fezes e excreção de nitrogênio, reduzido pH fecal, concentração plasmática posprandial de glicose, colesterol total, triglicerídeos e peso do pâncreas e maior concentração de glicose no jejum e peso do fígado. A proporção amilose e amilopectina nos grãos afeta significativamente a digestão do amido de arroz no trato

  8. Galaxy Zoo: Observing Secular Evolution Through Bars

    Science.gov (United States)

    Cheung, Edmond; Athanassoula, L.; Masters, K.; Faber, S. M.; Koo, D. C.; Zoo, Galaxy

    2014-01-01

    In this talk, I use the Galaxy Zoo 2 dataset to study the behavior of bars in disk galaxies as a function of specific star formation rate (SSFR), and inner galactic structure, i.e., the prominence of the bulge as parameterized by Sérsic index and central surface stellar mass density. Our sample consists of 13,295 disk galaxies, with an overall bar fraction of 23.6 ± 0.4%, of which 1,154 barred galaxies also have bar length measurements. These samples are the largest ever used to study the role of bars in disk galaxy evolution. I find that the likelihood of a galaxy hosting a bar is anti-correlated with SSFR, regardless of stellar mass or bulge prominence. I find that the trends of bar likelihood with bulge prominence are bimodal with SSFR, i.e., in star-forming galaxies, bulges are more prominent in galaxies more likely to host bars, while in quiescent disk galaxies, bars are less frequent where there are prominent bulges. Our observations of bar length reveal a complex picture. In star-forming disks, longer bars are found where the bulges are more prominent, while in quiescent disks there is a maximum in the average bar length as a function of bulge prominence. I interpret these observations using state-of-the-art simulations of bar evolution which include live halos and the effects of gas and star formation. I suggest our observed trends of bar likelihood with SSFR are driven by the gas fraction of the disks; a factor demonstrated to significantly retard both bar formation and evolution in models. I interpret the bimodal relationship between bulge prominence and bar properties as due to the complicated effects of classical bulges and central mass concentrations on bar evolution, and also to the growth of disky pseudobulges by bar evolution. These results represent empirical evidence for secular evolution driven by bars in disk galaxies. This work suggests that bars are not stagnant structures within disk galaxies, but are a critical evolutionary driver of their

  9. Search for \\bar{B}^0\\to\\Lambda_c^+\\bar{\\Lambda}_c^- decay at Belle

    OpenAIRE

    The Belle Collaboration; Abe, K

    2007-01-01

    We search for the doubly charmed baryonic decay $\\bar{B}^0\\to\\Lambda_c^+\\bar{\\Lambda}_c^-$, in a data sample of $520\\times10^6$ $B{\\bar B}$ events accumulated at the $\\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric e^+e^- collider. We find no significant signal and set an upper limit of ${\\cal B}(\\bar{B}^0\\to\\Lambda_c^+\\bar{\\Lambda}_c^-)

  10. Effect of bars on the galaxy properties

    CERN Document Server

    Vera, Matias; Coldwell, Georgina

    2016-01-01

    Aims: With the aim of assessing the effects of bars on disc galaxy properties, we present an analysis of different characteristics of spiral galaxies with strong, weak and without bars. Method: We identified barred galaxies from the Sloan Digital Sky Survey. By visual inspection, we classified the face-on spiral galaxies brighter than g<16.5 mag into strong-bar, weak-bar and unbarred. In order to provide an appropiate quantification of the influence of bars on galaxy properties, we also constructed a suitable control sample of unbarred galaxies with similar redshift, magnitude, morphology, bulge sizes, and local density environment distributions to that of barred galaxies. Results: We found 522 strong-barred and 770 weak-barred galaxies, representing a 25.82% of the full sample of spiral galaxies, in good agreement with previous studies. We also found that strong-barred galaxies show less efficient star formation activity and older stellar populations compared to weak-barred and unbarred spirals from the c...

  11. Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity

    OpenAIRE

    Layton Meredith J; Saad Mirette; Church Nicole L; Pearson Richard B; Mitchell Christina A; Phillips Wayne A

    2012-01-01

    Abstract Background The α-isoform of the Type 1A Phosphoinositide 3-kinases (PI3Kα) has protein kinase activity as well as phosphoinositide lipid kinase activity. The best described substrate for its protein kinase activity is its regulatory subunit, p85α, which becomes phosphorylated on Serine 608. Phosphorylation of Serine 608 has been reported to down-regulate its lipid kinase activity. Results We have assessed whether oncogenic mutants of PI3Kα, which have up-regulated lipid kinase activi...

  12. The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells

    DEFF Research Database (Denmark)

    da Silva Pinheiro, Paulo César; Jansen, Anna M; de Wit, Heidi;

    2014-01-01

    Protein Interacting with C Kinase 1 (PICK1) is a Bin/Amphiphysin/Rvs (BAR) domain protein involved in AMPA receptor trafficking. Here, we identify a selective role for PICK1 in the biogenesis of large, dense core vesicles (LDCVs) in mouse chromaffin cells. PICK1 colocalized with syntaxin-6, a......, consistent with an upstream role for PICK1. Disrupting lipid binding of the BAR domain (2K-E mutation) or of the PDZ domain (CC-GG mutation) was sufficient to reproduce the secretion phenotype of the null mutant. The same mutations are known to eliminate PICK1 function in receptor trafficking, indicating...

  13. Irradiation test of bar code label

    International Nuclear Information System (INIS)

    The irradiation test of bar code label tagged on radioactive waste container was done to determine the effect of radiation. Low and medium radioactive waste is that below total activity of 4,000Bq/g according to the Korean nuclear law. The irradiation amount to radiate bar code label tagged on radioactive waste container was calculated by MCNP-4b computer code. The nuclide such as Co-60 and Cs-137 was assumed to contribute 50 % of total activity. Real irradiation amount for bar code label was finally calculated by the dimensions of the container and the bar code label. The identification of post and the physical deflection of irradiated bar code label was tested by the bar code reader. The coated bar code label was suitable to use on low and medium radioactive waste container

  14. Atomic simulations of (10 1-bar 2), (10 1-bar 1) twinning and (10 1-bar 2) detwinning in magnesium

    International Nuclear Information System (INIS)

    (10 1-bar 2) and (10 1-bar 1) twinning and (10 1-bar 2) detwinning for Mg were investigated from the viewpoint of mobility of twinning dislocations and atomic shuffling. First-principles calculations suggested that the twinning dislocations glide more readily for the (10 1-bar 1) twinning than for the (10 1-bar 2) twinning. However, this conflicts with the experimental fact of easier (10 1-bar 2) twin formation. On the other hand, molecular dynamics simulations showed that the atomic shuffling was more activated for the (10 1-bar 2) twinning than for the (10 1-bar 1) twinning, which corresponds to the experimental fact. Therefore, it is suggested that the rate-controlling process for the twin formation is the atomic shuffling. Moreover, the calculations and simulations showed that the twinning dislocations glide more readily for the (10 1-bar 2) detwinning than for the (10 1-bar 2) twinning, whereas the atomic shuffling is less activated for the detwinning, suggesting that the detwinning occurs easily but is unstable, resulting in easy repetition of twinning–detwinning. (paper)

  15. Lipid14: The Amber Lipid Force Field

    OpenAIRE

    Dickson, Callum J.; Madej, Benjamin D.; Skjevik, Åge A.; Betz, Robin M.; Teigen, Knut; Gould, Ian R.; Walker, Ross C.

    2014-01-01

    The AMBER lipid force field has been updated to create Lipid14, allowing tensionless simulation of a number of lipid types with the AMBER MD package. The modular nature of this force field allows numerous combinations of head and tail groups to create different lipid types, enabling the easy insertion of new lipid species. The Lennard-Jones and torsion parameters of both the head and tail groups have been revised and updated partial charges calculated. The force field has been validated by si...

  16. First observation of B-bars0→Ds2*+Xμ-ν-bar decays

    International Nuclear Information System (INIS)

    Using data collected with the LHCb detector in proton-proton collisions at a centre-of-mass energy of 7 TeV, the semileptonic decays B-bars0→Ds+Xμ-ν-bar and B-bars0→D0K+Xμ-ν-bar are detected. Two structures are observed in the D0K+ mass spectrum at masses consistent with the known Ds1(2536)+ and Ds2*(2573)+ mesons. The measured branching fractions relative to the total B-bars0 semileptonic rate are B(B-bars0→Ds2*+Xμ-ν-bar)/B(B-bars0→Xμ-ν-bar)=(3.3±1.0±0.4)%, and B(B-bars0→Ds1+Xμ-ν-bar)/B(B-bars0→Xμ-ν-bar)=(5.4±1.2±0.5)%, where the first uncertainty is statistical and the second is systematic. This is the first observation of the Ds2*+ state in B-bars0 decays; we also measure its mass and width.

  17. Vibro-Impact Response of a Cracked Bar

    OpenAIRE

    Vikrant R. Hiwarkar; Vladimir I. Babitsky; Silberschmidt, Vadim V.

    2011-01-01

    The presence of a crack in a structure affects its dynamic behaviour under working conditions. Cracks introduce nonlinearities into the system; the use of such nonlinearities for damage detection should be investigated. A model of a one-dimensional cracked cantilever bar subjected to longitudinal harmonic excitation is used to analyse a vibro-impact response as a way to monitor structural health. The effect of contact nonlinearity due to crack's faces interaction is considered. This nonlinear...

  18. BaBar Data Aquisition

    CERN Document Server

    Scott, I; Grosso, P; Hamilton, R T; Huffer, M E; O'Grady, C; Russell, J J

    1998-01-01

    The BaBar experiment at the Stanford Linear Accelerator Center is designed to perform a search for CP violation by analysing the decays of a very large sample of B and Bbar mesons produced at the high luminosity PEP-11 accelerator. The data acquisition system must cope with a sustained high event rate, while supporting real time feature extraction and data compression with minimal dead time. The BaBar data acquisition system is based around a common VME interface to the electronics read-out of the separate detector subsystems. Data from the front end electronics is read into commercial VME processors via a custom "personality card" and PCI interface. The commercial CPUs run the Tornado operating system to provide a platform for detector subsystem code to perform the necessary data processing. The data are read out via a non-blocking network switch to a farm of commercial UNIX processors. Careful design of the core data acquisition code has enabled us to sustain events rates in excess of 20 kHz while maintaini...

  19. Results from bar pp colliders

    International Nuclear Information System (INIS)

    Recent results bar pp colliders are presented. From elastic scattering experiments at the Tevatron, an average value of σtot = 72.1±2 mb is reported, along with a new measurement of ρ = 0.13 ± 0.7. New measurements of jet direct photon and high pt W and Z production are compared to more precise, higher order predictions from perturbative QCD. Recently available data on the W mass and width give combined values for MW = 80.14±0.27 GeV/c2, and Γ(W) =2. 14 ± 0.08 GeV. From electroweak radiative corrections and MW, one finds Mtop = 130±40 GeV/c2, with a 95% C.L. upper limit at 210 GeV/c2. Current limits on Mtop are presented, along with a review of the prospects for top discovery. From jet data there is no evidence of quark substructure down to the distance scale of 1.4 x 10-17 cm, nor is there evidence for supersymmetry or heavy gauge bosons at bar pp colliders, allowing lower limits on MW, > 520 GeV/c2 and MZ 412 GeV/c2. 66 refs., 26 figs

  20. Anti vibration bars replacement in Vandellos II steam generators

    International Nuclear Information System (INIS)

    C.N. Vandellos II is equipped with three steam generators Westinghouse model F. The number of tubes is 5626 each SG and the material Inconel 600TT. During the first inservice inspection, in 1989, tube wall thickness reductions were observed due to fretting in zones of contact with the tubes anti vibration bars. In the 2 nd shutdown for refueling (1990) all the tubes subject to this type of degradation were inspected by eddy currents, occurring a significative increase in number of tubes affected as well as the quantity of plugged tubes for that reason. Additionally, Westinghouse performed visual inspection and dimensional control of gaps in the tube bundles. Taking in account the results, the replacement with AVBs of new design was decided. AVBs new design is more complex than the original due to the combination of flexible and expandable bars in order to eliminate gaps between tubes an bars an assure proper bundle support. Given that the installation has to be done under water for shielding, all unions are bolted so that no welding is required. Each one of the bars, 333 per SG, is attached to a support structure consisting in 6 retaining plates and 4 bridge plates. (Author)

  1. Loss of halo triaxiality due to bar formation

    CERN Document Server

    Machado, Rubens E G

    2010-01-01

    Cosmological N-body simulations indicate that the dark matter haloes of galaxies should be generally triaxial. Yet, the presence of a baryonic disc is believed to alter the shape of the haloes. Here we aim to study how bar formation is affected by halo triaxiality and how, in turn, the presence of the bar influences the shape of the halo. We perform a set of collisionless N-body simulations of disc galaxies with triaxial dark matter haloes, using elliptical discs as initial conditions. We study models of different halo triaxialities and, to investigate the behaviour of the halo shape in the absence of bar formation, we run models with different disc masses, halo concentrations, disc velocity dispersions and also models where the disc shape is kept artificially axisymmetric. We find that the introduction of a massive disc causes the halo triaxiality to be partially diluted. Once the disc is fully grown, a strong stellar bar develops within the halo that is still non-axisymmetric, causing it to lose its remaini...

  2. Rings and spirals in barred galaxies. I Building blocks

    CERN Document Server

    Athanassoula, E; Masdemont, J J

    2008-01-01

    In this paper we present building blocks which can explain the formation and properties both of spirals and of inner and outer rings in barred galaxies. We first briefly summarise the main results of the full theoretical description we have given elsewhere, presenting them in a more physical way, aimed to an understanding without the requirement of extended knowledge of dynamical systems or of orbital structure. We introduce in this manner the notion of manifolds, which can be thought of as tubes guiding the orbits. The dynamics of these manifolds can govern the properties of spirals and of inner and outer rings in barred galaxies. We find that the bar strength affects how unstable the L1 and L2 Lagrangian points are, the motion within the 5A5A5Amanifold tubes and the time necessary for particles in a manifold to make a complete turn around the galactic centre. We also show that the strength of the bar, or, to be more precise, of the non-axisymmetric forcing at and somewhat beyond the corotation region, deter...

  3. P{bar P} collider physics

    Energy Technology Data Exchange (ETDEWEB)

    Demarteau, M. [State Univ. of New York, Stony Brook, NY (United States)

    1992-04-01

    A brief introduction to {bar p}p collider physics is given. Selected results from the collider experiments at the CERN S{bar p}pS and the Tevatron collider are described. The emphasis is on experimental aspects of {bar p}p collisions. Minimum bias physics and the production of jets, Intermediate Vector Bosons and heavy flavors is reviewed. The outlook for physics at hadron colliders for the near future is briefly discussed.

  4. Predictions for $B \\to \\tau \\bar{\\mu} + \\mu \\bar{\\tau} $

    CERN Document Server

    Boubaa, D; Duraisamy, M; Khalil, S

    2012-01-01

    The observation of $B \\to \\tau \\bar{\\mu} + \\mu \\bar{\\tau} $ at present experiments would be a clear sign of new physics. In this paper we calculate this process in a 2HDM framework where the decay is mediated by the exchange of spin zero particle with flavour changing neutral current couplings. If we identify the scalar with the the newly discovered state at LHC with a mass $% \\sim 125 $ GeV then we get $BR(B_s \\to \\tau \\bar{\\mu} + \\mu \\bar{\\tau}) \\sim 10^{-6}$ and $BR(B_d \\to \\tau \\bar{\\mu} + \\mu \\bar{\\tau}) \\sim 10^{-7}$. We also calculate this process in minimal supersymmetric standard model and find $BR(B_s \\to \\tau \\bar{\\mu} + \\mu \\bar{\\tau}) \\sim 10^{-11}$.

  5. PREDICTIONS FOR $B \\to \\tau \\bar{\\mu} + \\mu \\bar{\\tau}$

    Science.gov (United States)

    Boubaa, Dris; Datta, Alakabha; Duraisamy, Murugeswaran; Khalil, Shaaban

    2013-12-01

    The observation of B -> τ \\bar {μ } + μ \\bar {τ } at present experiments would be a clear sign of new physics. In this paper, we calculate this process in an extended Higgs sector framework where the decay is mediated by the exchange of spin zero particle with flavor changing neutral current couplings. If we identify the scalar with the newly discovered state at LHC with a mass 125 GeV then we find that, after imposing all experimental constraints, the BR(Bs -> τ \\bar {μ } + μ \\bar {τ }) can be as high as 10-6 and BR (Bd -> τ \\bar {μ } + μ \\bar {τ }) can be as high as 10-7. We also calculate this process in the minimal supersymmetric standard model and find the BR(Bs ->τ \\bar {μ } + μ \\bar {τ }) is typically of the order 10-8.

  6. Chiral Perturbation Theory and the $\\bar B \\bar B$ Strong Interaction

    CERN Document Server

    Liu, Zhan-Wei; Zhu, Shi-Lin

    2012-01-01

    We have calculated the potentials of the heavy (charmed or bottomed) pseudoscalar mesons up to $O(\\epsilon^2)$ with the heavy meson chiral perturbation theory. We take into account the contributions from the football, triangle, box, and crossed diagrams with the 2$\\phi$ exchange and one-loop corrections to the contact terms. We notice that the total 2$\\phi$-exchange potential alone is attractive in the small momentum region in the channel ${\\bar B \\bar B}^{I=1}$, ${\\bar B_s \\bar B_s}^{I=0}$, or ${\\bar B \\bar B_s}^{I=1/2}$, while repulsive in the channel ${\\bar B \\bar B}^{I=0}$. Hopefully the analytical chiral structures of the potentials may be useful in the extrapolation of the heavy meson interaction from lattice QCD simulation.

  7. B-bar → πlν-bar at three lattice spacings

    International Nuclear Information System (INIS)

    The increasing accuracy of experimental results for the exclusive, semileptonic decay B-bar → πlν-bar requires a similarly accurate calculation of the hadronic matrix elements, to determine vertical bar Vub vertical bar. We present preliminary results for the form factors of the B to light meson decay mode. Using results from three lattices in the range 5.7 ≤ β ≤ 6.1 we study the dependence on the lattice spacing

  8. Heart Disease Affects Women of All Ages

    Science.gov (United States)

    Skip Navigation Bar Home Current Issue Past Issues Heart Disease Affects Women of All Ages Past Issues / Winter ... weeks of a heart attack. For Women with Heart Disease: About 6 million American women have coronary heart ...

  9. Orbital Support of Fast and Slow Inner Bars in Double Barred Galaxies

    CERN Document Server

    Maciejewski, Witold

    2010-01-01

    We analyze how the orbital support of the inner bar in a double-barred galaxy (nested bars) depends on the angular velocity (i.e. pattern speed) of this bar. We study orbits in seven models of double bars using the method of invariant loops. The range of pattern speed is covered exhaustively. We find that not all pattern speeds are allowed when the inner bar rotates in the same direction as the outer bar. Below a certain minimum pattern speed orbital support for the inner bar abruptly disappears, while at high values of this speed the orbits indicate an increasingly round bar that looks more like a twist in the nuclear isophotes than a dynamically independent component. For values between these two extremes, orbits supporting the inner bar extend further out as the bar's pattern speed decreases, their corresponding loops become more eccentric, pulsate more, and their rotation becomes increasingly non-uniform, as they speed up and slow down in their motion. Lower pattern speeds also lead to a less coherent bar...

  10. Lipid nanoparticle interactions and assemblies

    Science.gov (United States)

    Preiss, Matthew Ryan

    oxide nanoparticles encapsulated in the lipid bilayer, the local temperature and membrane fluidity could be observed. DLNAs were encapsulated with different sized nanoparticles and concentrations in order to observe the effect of the bilayer nanoparticles on the lipid bilayer's phase behavior and leakage. Two different sized nanoparticles were used, a 2 nm gold nanoparticle (GNP) much smaller than the thickness of the bilayer and a 4 nm GNP near the thickness of the lipid bilayer. The 2 nm GNPs were shown to affect the lipid bilayer differently than the 4 nm GNP. Specifically, the two nanoparticles altered the phase behavior and leakage differently in a temperature dependent fashion, demonstrating that embedded nanoparticle size can be used induce or inhibit bilayer leakage. A dual solvent exchange method was used to control the lipid surface composition of an iron oxide nanoparticle with a cationic lipid and a polyethylene glycol (PEG) lipid to produce lipid coated magnetic nanoparticles (LMNPs). PEG is well known for its ability to enhance the pharmacokinetics of nanostructures by preventing uptake by the immune system. By controlling the lipid surface composition, the surface charge and PEG conformation can be controlled which allowed the LMNPs to be used as an MRI contrast agent and a delivery system for siRNA that could be triggered with temperature.

  11. Method for extracting internal lipids from wool using supercritical fluids

    OpenAIRE

    Coderch Negra, M. Luisa; Ramírez Mileo, Raquel; Martí Gelabert, Meritxell; Parra Juez, José Luis; Garay Peral, Iratxe; Salas Baquero, Oscar; Alvarez Alcega, Jorge

    2008-01-01

    [EN] A method for extracting internal lipids from wool that is substantially free of lanolin, comprising the use of a fluid under supercritical conditions and an agent that can change the polarity of said fluid, selected from methanol and/or ethanol, is disclosed. According to the operating conditions described, the temperature is between 40 DEG C. and 120 DEG C., and the pressure is between 120 bars and 330 bars. The polarity-changing agent represents between 3% and 15% expressed as volume/v...

  12. Loss of power of a 220 VAC safety bus bar at Embalse NPP

    International Nuclear Information System (INIS)

    Embalse nuclear power plant is located at the Cordoba Province, 5 kilometres Southern the town of Embalse. It is equipped with one 600 MWe CANDU reactor. At the time of the event, which occurred on 11 October 2004, the plant was operating normally at full power. The Embalse nuclear power plant electrical power system buses are classified, in reliability decreasing order, into the following four different levels: 1) Class I: uninterrupted direct current supplies for safety related and other essential loads; 2) Class II: uninterrupted alternating current supplies for safety related and other essential loads; 3) Class III: alternating current supplies to essential auxiliaries which can tolerate the short interruption required until to start up and load the on-site standby generators and 4) Class IV: normal alternating current supplies to auxiliaries which can tolerate long duration interruptions without affecting personnel or equipment safety (Class IV is the normal source of power to Class III system). In particular, the Class II 220 VAC uninterrupted monophasic safety bus bars are composed by three 220 VAC subsystems powered by the following two sources of power: Class I uninterrupted safety bus bars (5551 BUA, BUB and BUC bars) and Class III secondary distribution 5433-MCC5 and MCC6. The Class II 220 VAC bus bars are normally powered from Class I bus bars through static monophasic inverters. Beside, in a static monophasic out of service case, Class II bus bar affected could be powered from Class III bus bars via a transformer stabilizer. Class II bus bars supplies power to both control computers and the AC instrumentation and control devices. When 220 VAC (Class II) 5542-BUC-monophasic-inverter failure was coincident with a subsequent independent failure to transfer to the Class III through static commuter 5542-SVR-C, a loss of the 220 VAC uninterrupted monophasic safety bus bar (Class II) event was caused. (author)

  13. Bar Study Stories. Issues in Prevention

    Science.gov (United States)

    Higher Education Center for Alcohol, Drug Abuse, and Violence Prevention, 2012

    2012-01-01

    This issue of "Issues in Prevention" focuses on the impact of the availability of drinks in licensed establishments, such as bars and taverns on student drinking. This issue contains the following articles: (1) Cheap Drinks at College Bars Can Escalate Student Drinking (John D. Clapp); (2) High Alcohol Outlet Density: A Problem for Campuses and…

  14. The Bar Tack Machine. Module 16.

    Science.gov (United States)

    South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

    This module on the bar tack machine, one in a series dealing with industrial sewing machines, their attachments, and operation, covers one topic: performing special operations on the bar tack machine. These components are provided: an introduction, directions, an objective, learning activities, student information, a student self-check, and a…

  15. The impact of lipid composition on the stability of the tear fluid lipid layer

    DEFF Research Database (Denmark)

    Kulovesi, P.; Telenius, J.; Koivuniemi, A.;

    2012-01-01

    The tear fluid protects the corneal epithelium from drying and pathogens and it also provides nutrients to these cells. Tear fluid is composed of an aqueous layer as well as a lipid layer that resides at the air-tear interface. The function of the lipid layer is to lower the surface tension of the...... tear fluid and probably prevent evaporation. We have studied the impact of lipid composition on the structural and dynamical properties of the tear lipid film using Langmuir films, X-ray diffraction, and coarse-grained molecular dynamics simulations. Based on recently published lipidomic data, we have...... selected a number of model systems comprised of phospholipids, cholesteryl oleates, triglycerides, and free fatty acids to study how the organization, stability, and dynamics of the lipid layer depend on its composition. In particular our aim is to unravel how excess neutral lipids affect the stability and...

  16. Yeast Ivy1p Is a Putative I-BAR-domain Protein with pH-sensitive Filament Forming Ability in vitro.

    Science.gov (United States)

    Itoh, Yuzuru; Kida, Kazuki; Hanawa-Suetsugu, Kyoko; Suetsugu, Shiro

    2016-01-01

    Bin-Amphiphysin-Rvs161/167 (BAR) domains mold lipid bilayer membranes into tubules, by forming a spiral polymer on the membrane. Most BAR domains are thought to be involved in forming membrane invaginations through their concave membrane binding surfaces, whereas some members have convex membrane binding surfaces, and thereby mold membranes into protrusions. The BAR domains with a convex surface form a subtype called the inverse BAR (I-BAR) domain or IRSp53-MIM-homology domain (IMD). Although the mammalian I-BAR domains have been studied, those from other organisms remain elusive. Here, we found putative I-BAR domains in Fungi and animal-like unicellular organisms. The fungal protein containing the putative I-BAR-domain is known as Ivy1p in yeast, and is reportedly localized in the vacuole. The phylogenetic analysis of the I-BAR domains revealed that the fungal I-BAR-domain containing proteins comprise a distinct group from those containing IRSp53 or MIM. Importantly, Ivy1p formed a polymer with a diameter of approximately 20 nm in vitro, without a lipid membrane. The filaments were formed at neutral pH, but disassembled when pH was reverted to basic. Moreover, Ivy1p and the I-BAR domain expressed in mammalian HeLa cells was localized at a vacuole-like structure as filaments as revealed by super-resolved microscopy. These data indicate the pH-sensitive polymer forming ability and the functional conservation of Ivy1p in eukaryotic cells. PMID:26657738

  17. Dynamical evolution of two associated galactic bars

    CERN Document Server

    Garzon, F

    2014-01-01

    We study the dynamical interactions of mass systems in equilibrium under their own gravity that mutually exert and experience gravitational forces. The method we employ is to model the dynamical evolution of two isolated bars, hosted within the same galactic system, under their mutual gravitational interaction. In this study we present an analytical treatment of the secular evolution of two bars that oscillate with respect one another. Two cases of interaction, with and without geometrical deformation, are discussed. In the latter case, the bars are described as modified Jacobi ellipsoids. These triaxial systems are formed by a rotating fluid mass in gravitational equilibrium with its own rotational velocity and the gravitational field of the other bar. The governing equation for the variation of their relative angular separation is then numerically integrated, which also provides the time evolution of the geometrical parameters of the bodies. The case of rigid, non-deformable, bars produces in some cases an ...

  18. OPG operational experience with stator conductor bars fouling

    International Nuclear Information System (INIS)

    Over the last three years, Ontario Power Generation (OPG) Pickering Nuclear has experienced fouling of the stator conductor bar cooling water channels on two units. To address the associated stator bar temperature rises, chemical cleaning was undertaken three times on one unit and once on the other. These events were the subject of two formal investigations and a single rigorous chemistry assessment. The investigations were conducted using a formalized root-cause protocol. The assessment involved a system chemistry review over a 10-year period and a critical evaluation of dissolved oxygen control. This paper describes: - the internal investigations undertaken by OPG to better understand and resolve the problem, - OPG's cleaning strategy and different cleaning options performed on affected units, - the remedial actions undertaken by OPG, and - The interim actions following the final post-cleaning inspections. (orig.)

  19. The role of the kidney in lipid metabolism

    DEFF Research Database (Denmark)

    Moestrup, Søren K; Nielsen, Lars Bo

    2005-01-01

    PURPOSE OF REVIEW: Cellular uptake of plasma lipids is to a large extent mediated by specific membrane-associated proteins that recognize lipid-protein complexes. In the kidney, the apical surface of proximal tubules has a high capacity for receptor-mediated uptake of filtered lipid-binding plasma...... proteins. We describe the renal receptor system and its role in lipid metabolism in health and disease, and discuss the general effect of the diseased kidney on lipid metabolism. RECENT FINDINGS: Megalin and cubilin are receptors in the proximal tubules. An accumulating number of lipid-binding and...... regulating proteins (e.g. albumin, apolipoprotein A-I and leptin) have been identified as ligands, suggesting that their receptors may directly take up lipids in the proximal tubules and indirectly affect plasma and tissue lipid metabolism. Recently, the amnionless protein was shown to be essential for the...

  20. Vincristine Lipid Complex Injection

    Science.gov (United States)

    Vincristine lipid complex is used to treat a certain type of acute lymphoblastic leukemia (ALL; a type ... at least two different treatments with other medications. Vincristine lipid complex is in a class of medications ...

  1. Irinotecan Lipid Complex Injection

    Science.gov (United States)

    Irinotecan lipid complex is used in combination with other medications to treat pancreatic cancer that has spread to other parts of ... after treatment with other chemotherapy medications. Irinotecan lipid complex is in a class of antineoplastic medications called ...

  2. Vincristine Lipid Complex Injection

    Science.gov (United States)

    Vincristine lipid complex is used to treat a certain type of acute lymphoblastic leukemia (ALL; a type of cancer of the ... two different treatments with other medications. Vincristine lipid complex is in a class of medications called vinca ...

  3. Doxorubicin Lipid Complex Injection

    Science.gov (United States)

    Doxorubicin lipid complex is used to treat ovarian cancer that has not improved or that has worsened after treatment with other medications. Doxorubicin lipid complex is also used to treat Kaposi's sarcoma (a ...

  4. Cytarabine Lipid Complex Injection

    Science.gov (United States)

    Cytarabine lipid complex is used to treat lymphomatous meningitis (a type of cancer in the covering of the spinal cord and brain). Cytarabine lipid complex is in a class of medications called antimetabolites. ...

  5. Crystallization modifiers in lipid systems.

    Science.gov (United States)

    Ribeiro, Ana Paula Badan; Masuchi, Monise Helen; Miyasaki, Eriksen Koji; Domingues, Maria Aliciane Fontenele; Stroppa, Valter Luís Zuliani; de Oliveira, Glazieli Marangoni; Kieckbusch, Theo Guenter

    2015-07-01

    Crystallization of fats is a determinant physical event affecting the structure and properties of fat-based products. The stability of these processed foods is regulated by changes in the physical state of fats and alterations in their crystallization behavior. Problems like polymorphic transitions, oil migration, fat bloom development, slow crystallization and formation of crystalline aggregates stand out. The change of the crystallization behavior of lipid systems has been a strategic issue for the processing of foods, aiming at taylor made products, reducing costs, improving quality, and increasing the applicability and stability of different industrial fats. In this connection, advances in understanding the complex mechanisms that govern fat crystallization led to the development of strategies in order to modulate the conventional processes of fat structuration, based on the use of crystallization modifiers. Different components have been evaluated, such as specific triacyglycerols, partial glycerides (monoacylglycerols and diacylglycerols), free fatty acids, phospholipids and emulsifiers. The knowledge and expertise on the influence of these specific additives or minor lipids on the crystallization behavior of fat systems represents a focus of current interest for the industrial processing of oils and fats. This article presents a comprehensive review on the use of crystallization modifiers in lipid systems, especially for palm oil, cocoa butter and general purpose fats, highlighting: i) the removal, addition or fractionation of minor lipids in fat bases; ii) the use of nucleating agents to modify the crystallization process; iii) control of crystallization in lipid bases by using emulsifiers. The addition of these components into lipid systems is discussed in relation to the phenomena of nucleation, crystal growth, morphology, thermal behavior and polymorphism, with the intention of providing the reader with a complete panorama of the associated mechanisms

  6. Monstrous Mycobacterial Lipids.

    Science.gov (United States)

    Seeliger, Jessica; Moody, D Branch

    2016-02-18

    When it comes to lipid diversity, no bacterial genus approaches Mycobacterium. In this issue of Cell Chemical Biology, Burbaud et al. (2016) provide a multi-genic working model for the biosynthesis of trehalose polyphleate (TPP), one of the largest known lipids in mycobacteria. They demonstrate that this lipid is made by diverse mycobacterial species, including those of medical importance. PMID:26971870

  7. Solid lipid nanoparticles from amphiphilic calixpyrroles

    OpenAIRE

    Helttunen, Kaisa; Galán, Albano; Ballester, Pablo; Bergenholtz, Johan; Nissinen, Maija

    2016-01-01

    Hypothesis Macrocyclic amphiphiles form interesting self-assembling structures, including solid lipid nanoparticles, which have potential applications in drug encapsulation. Aryl-extended calixpyrroles, which act as anion binding hosts, are expected to form solid lipid nanoparticles, even though the alkyl chains have unusual perpendicular geometry with respect to the hydrophilic head group. The preparation conditions and the alkyl chain length should affect the size and stability of the p...

  8. Reactivity of lipids during cereal processing

    OpenAIRE

    Lehtinen, Pekka

    2003-01-01

    The study elucidates factors affecting the reactivity of lipids in multiphase food systems, such as processed cereal food products. By using oat and oat products as model materials, both enzymatic and non-enzymatic lipid reactions were studied in aqueous suspensions and in dry flour. The information obtained can be used to improve existing cereal processing schemes and to develop new processing technologies for obtaining high quality food products with enhanced shelf stability. In aqueous...

  9. Impact resistance of bar glasses.

    Science.gov (United States)

    Shepherd, J P; Huggett, R H; Kidner, G

    1993-12-01

    Bar glasses are often used as weapons in interpersonal violence. Violence often erupts spontaneously and assailants use objects close to hand as weapons. After an initial national Accident and Emergency Department study to identify glass designs most often implicated in interpersonal violence, the impact resistance of 1-pint beer glasses was tested in a materials laboratory with a Zwick 5102 pendulum impact tester. Both straight-sided (nonik) glasses (annealed and tempered) and handled tankards (annealed) were tested to destruction. The impact resistance of new glasses was compared with that of glasses subjected to wear. The mean impact resistance of new annealed noniks did not differ significantly although new glasses were significantly more resistant than worn glasses (p shards although the thicker bases remained intact. The mean impact resistance of new annealed noniks was 0.5 J, of worn annealed noniks 0.08 J, of tempered new noniks > 4 J, of worn tempered noniks 0.18 J, and of tankards, 1.7 J.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8263994

  10. Do Bars Drive Spiral Density Waves?

    CERN Document Server

    Buta, R J; Elmegreen, B G; Salo, H; Laurikainen, E; Elmegreen, D M; Puerari, I; Block, D L

    2009-01-01

    We present deep near-infrared K_s-band AAT IRIS2 observations of a selected sample of nearby barred spiral galaxies, including some with the strongest known bars. The sample covers a range of Hubble types from SB0- to SBc. The goal is to determine if the torque strengths of the spirals correlate with those of the bars, which might be expected if the bars actually drive the spirals as has been predicted by theoretical studies. This issue has implications for interpreting bar and spiral fractions at high redshift. Analysis of previous samples suggested that such a correlation exists in the near-infrared, where effects of extinction and star formation are less important. However, the earlier samples had only a few excessively strong bars. Our new sample largely confirms our previous studies, but still any correlation is relatively weak. We find two galaxies, NGC 7513 and UGC 10862, where there is a only a weak spiral in the presence of a very strong bar. We suggest that some spirals probably are driven by their ...

  11. Barred Galaxies in the Coma Cluster

    CERN Document Server

    Marinova, Irina; Trentham, Neil; Ferguson, Henry C; Weinzirl, Tim; Balcells, Marc; Carter, David; Brok, Mark den; Erwin, Peter; Graham, Alister W; Goudfrooij, Paul; Guzman, Rafael; Hammer, Derek; Hoyos, Carlos; Peletier, Reynier F; Huxor, Avon P; Peng, Erik; Kleijn, Gijs Verdoes

    2010-01-01

    We use ACS data from the HST Treasury survey of the Coma cluster (z~0.02) to study the properties of barred galaxies in the Coma core, the densest environment in the nearby Universe. This study provides a complementary data point for studies of barred galaxies as a function of redshift and environment. From ~470 cluster members brighter than M_I = -11 mag, we select a sample of 46 disk galaxies (S0--Im) based on visual classification. The sample is dominated by S0s for which we find an optical bar fraction of 47+/-11% through ellipse fitting and visual inspection. Among the bars in the core of the Coma cluster, we do not find any very large (a_bar > 2 kpc) bars. Comparison to other studies reveals that while the optical bar fraction for S0s shows only a modest variation across low-to-intermediate density environments (field to intermediate-density clusters), it can be higher by up to a factor of ~2 in the very high-density environment of the rich Coma cluster core.

  12. Tidally Induced Bars of Galaxies in Clusters

    Science.gov (United States)

    Łokas, Ewa L.; Ebrová, Ivana; del Pino, Andrés; Sybilska, Agnieszka; Athanassoula, E.; Semczuk, Marcin; Gajda, Grzegorz; Fouquet, Sylvain

    2016-08-01

    Using N-body simulations, we study the formation and evolution of tidally induced bars in disky galaxies in clusters. Our progenitor is a massive, late-type galaxy similar to the Milky Way, composed of an exponential disk and a Navarro-Frenk-White dark matter halo. We place the galaxy on four different orbits in a Virgo-like cluster and evolve it for 10 Gyr. As a reference case, we also evolve the same model in isolation. Tidally induced bars form on all orbits soon after the first pericenter passage and survive until the end of the evolution. They appear earlier, are stronger and longer, and have lower pattern speeds for tighter orbits. Only for the tightest orbit are the properties of the bar controlled by the orientation of the tidal torque from the cluster at pericenter. The mechanism behind the formation of the bars is the angular momentum transfer from the galaxy stellar component to its halo. All of the bars undergo extended periods of buckling instability that occur earlier and lead to more pronounced boxy/peanut shapes when the tidal forces are stronger. Using all simulation outputs of galaxies at different evolutionary stages, we construct a toy model of the galaxy population in the cluster and measure the average bar strength and bar fraction as a function of clustercentric radius. Both are found to be mildly decreasing functions of radius. We conclude that tidal forces can trigger bar formation in cluster cores, but not in the outskirts, and thus can cause larger concentrations of barred galaxies toward the cluster center.

  13. Star Formation Properties in Barred Galaxies(SFB). III. Statistical Study of Bar-driven Secular Evolution using a sample of nearby barred spirals

    CERN Document Server

    Zhou, Zhi-Min; Wu, Hong

    2014-01-01

    Stellar bars are important internal drivers of secular evolution in disk galaxies. Using a sample of nearby spiral galaxies with weak and strong bars, we explore the relationships between the star formation feature and stellar bars in galaxies. We find that galaxies with weak bars tend to be coincide with low concentrical star formation activity, while those with strong bars show a large scatter in the distribution of star formation activity. We find enhanced star formation activity in bulges towards stronger bars, although not predominantly, consistent with previous studies. Our results suggest that different stages of the secular process and many other factors may contribute to the complexity of the secular evolution. In addition, barred galaxies with intense star formation in bars tend to have active star formation in their bulges and disks, and bulges have higher star formation densities than bars and disks, indicating the evolutionary effects of bars. We then derived a possible criterion to quantify the ...

  14. Nearshore bar migration and sediment-induced buoyancy effects

    Science.gov (United States)

    Falchetti, Silvia; Conley, Daniel C.; Brocchini, Maurizio; Elgar, Steve

    2010-02-01

    A 1-D General Ocean Turbulence Model that includes the effects of sediment-induced stratification is shown to simulate the observed onshore and offshore migration of a nearshore sandbar. The only two free parameters of the model, the bed reference concentration and the sediment diffusivity, are taken from the literature, rather than tuned to the data used here. The model results suggest that predictions of onshore bar migration, in which wave-induced sediment transport confined to within a few centimeters of the bottom dominates, are not greatly affected by accounting for buoyancy effects. The model results also suggest that both mean flows and waves transport sediment during offshore bar migration, with different components of transport dominating at different cross-shore locations across the bar-trough bathymetry. Neglecting the effects of sediment-induced stratification results in higher model skill during the largest waves, likely because the excess turbulence production simulated by the non-stratified model is counterbalanced by neglected breaking-wave-generated turbulence. Considering both onshore and offshore migration, the model that includes sediment-induced stratification has higher skill than the model without stratification.

  15. Two-Dimensional Magnetohydrodynamic Simulations of Barred Galaxies

    CERN Document Server

    Kim, Woong-Tae

    2012-01-01

    Barred galaxies are known to possess magnetic fields that may affect the properties of bar substructures such as dust lanes and nuclear rings. We use two-dimensional high-resolution magnetohydrodynamic (MHD) simulations to investigate the effects of magnetic fields on the formation and evolution of such substructures as well as on the mass inflow rates to the galaxy center. The gaseous medium is assumed to be infinitesimally-thin, isothermal, non-self-gravitating, and threaded by initially uniform, azimuthal magnetic fields. We find that there exists an outermost x1-orbit relative to which gaseous responses to an imposed stellar bar potential are completely different between inside and outside. Inside this orbit, gas is shocked into dust lanes and infalls to form a nuclear ring. Magnetic fields are compressed in dust lanes, reducing their peak density. Magnetic stress removes further angular momentum of the gas at the shocks, temporarily causing the dust lanes to bend into an 'L' shape and eventually leading ...

  16. Function and regulation of lipid biology in Caenorhabditis elegans aging

    Directory of Open Access Journals (Sweden)

    Nicole Shangming Hou

    2012-05-01

    Full Text Available Rapidly expanding aging populations and a concomitant increase in the prevalence of age-related diseases are global health problems today. Over the past three decades, a large body of work has led to the identification of genes and regulatory networks that affect longevity and health span, often benefitting from the tremendous power of genetics in vertebrate and invertebrate model organisms. Interestingly, many of these factors appear linked to lipids, important molecules that participate in cellular signaling, energy metabolism, and structural compartmentalization. Despite the putative link between lipids and longevity, the role of lipids in aging remains poorly understood. Emerging data from the model organism Caenorhabditis elegans suggest that lipid composition may change during aging, as several pathways that influence aging also regulate lipid metabolism enzymes; moreover, some of these enzymes apparently play key roles in the pathways that affect the rate of aging. By understanding how lipid biology is regulated during C. elegans aging, and how it impacts molecular, cellular and organismal function, we may gain insight into novel ways to delay aging using genetic or pharmacological interventions. In the present review we discuss recent insights into the roles of lipids in C. elegans aging, including regulatory roles played by lipids themselves, the regulation of lipid metabolic enzymes, and the roles of lipid metabolism genes in the pathways that affect aging.

  17. ${{\\bar{d}} - {\\bar{u}}}$ Flavor Asymmetry in the Proton in Chiral Effective Field Theory

    Energy Technology Data Exchange (ETDEWEB)

    Salamu, Y. [Institute of High Energy Physics, CAS, Beijing, 100049, China; Ji, Cheung-Ryong [North Carolina State University, Raleigh, NC; Melnitchouk, Wally [Jefferson Lab, Newport News, VA; Wang, P. [Theoretical Physics Center for Science Facilities, CAS, Beijing, 100049, China

    2015-09-01

    The ${\\bar d - \\bar u}$ flavor asymmetry in the proton arising from pion loops is computed using chiral effective field theory. The calculation includes both nucleon and Δ intermediate states, and uses both the fully relativistic and heavy baryon frameworks. The x dependence of ${\\bar d - \\bar u}$ extracted from the Fermilab E866 Drell–Yan data can be well reproduced in terms of a single transverse momentum cutoff parameter regulating the ultraviolet behavior of the loop integrals. In addition to the distribution at x > 0, corrections to the integrated asymmetry from zero momentum contributions are computed, which arise from pion rainbow and bubble diagrams at x = 0. These have not been accounted for in previous analyses, and can make important contributions to the lowest moment of ${\\bar d-\\bar u}$ .

  18. BARS DO DRIVE SPIRAL DENSITY WAVES

    International Nuclear Information System (INIS)

    Recently, Buta et al. examined the question 'Do Bars Drive Spiral Density Waves?', an idea supported by theoretical studies and also from a preliminary observational analysis. They estimated maximum bar strengths Qb , maximum spiral strengths Qs , and maximum m = 2 arm contrasts A 2s for 23 galaxies with deep Anglo-Australian Telescope (AAT) Ks -band images. These were combined with previously published Qb and Qs values for 147 galaxies from the Ohio State University Bright Spiral Galaxy Survey (OSUBSGS) sample and with the 12 galaxies from Block et al. Weak correlation between Qb and Qs was confirmed for the combined sample, whereas the AAT subset alone showed no significant correlations between Qb and Qs , nor between Qb and A 2s. A similar negative result was obtained in Durbala et al. for 46 galaxies. Based on these studies, the answer to the above question remains uncertain. Here we use a novel approach, and show that although the correlation between the maximum bar and spiral parameters is weak, these parameters do correlate when compared locally. For the OSUBSGS sample, a statistically significant correlation is found between the local spiral amplitude, and the forcing due to the bar's potential at the same distance, out to ∼1.6 bar radii (the typical bar perturbation is then of the order of a few percent). Also for the sample of 23 AAT galaxies of Buta et al., we find a significant correlation between local parameters out to ∼1.4 bar radii. Our new results confirm that, at least in a statistical sense, bars do indeed drive spiral density waves.

  19. Chocolate Bars Based on Human Nutritional Requirements

    OpenAIRE

    Robson, Anthony

    2013-01-01

    International audience Key Points * The nutritional value of chocolate bars should be based on the nutritional value of the low energy dense late Paleolithic human diet to help reduce mental ill health, obesity, and other postprandial insults. * Current chocolate bars have a high energy density (>2 kcal/g). * Cocoa can be sweetened by the addition of calorie-free Purefruit™ (Tate & Lyle) monk fruit ( Siraitia grosvenorii ) extract. PUREFRUIT™ is approximately 200 times sweeter than sugar a...

  20. The DIRC detector at BaBar

    International Nuclear Information System (INIS)

    A dedicated particle identification system based on the Detection of Internally Reflected Cherenkov (DIRC) light will be used in the BaBar detector. We provide an overview of the DIRC concept, design, and expected performance of the production device and a status report on its construction and commissioning. The DIRC is expected to be operating in the BaBar detector on beam line at the PEP-II B Factory in late spring 1999

  1. The Influence of Bars on Nuclear Activity

    CERN Document Server

    Ho, L C; Sargent, W L W; Ho, Luis C.; Filippenko, Alexei V.; Sargent, Wallace L. W.

    1997-01-01

    We test ideas on fueling of galactic nuclei by bar-driven inflow by comparing the detection rate and intensity of nuclear H II regions and AGNs among barred and unbarred galaxies in a sample of over 300 spirals selected from our recent optical spectroscopic survey of nearby galaxies. Among late-type spirals (Sc-Sm), but not early-type (S0/a-Sbc), we observe in the barred group a very marginal increase in the detection rate of H II nuclei and a corresponding decrease in the incidence of AGNs. The minor differences in the detection rates, however, are statistically insignificant, most likely stemming from selection effects and not from a genuine influence from the bar. The presence of a bar seems to have no noticeable impact on the likelihood of a galaxy to host either nuclear star formation or an AGN. The nuclei of early-type barred spirals do exhibit measurably higher star-formation rates than their unbarred counterparts, as indicated by either the luminosity or the equivalent width of H-alpha emission. By co...

  2. Hot Disks And Delayed Bar Formation

    CERN Document Server

    Sheth, Kartik; Elmegreen, Debra Meloy; Elmegreen, Bruce G; Athanassoula, E; Weiner, Ben

    2012-01-01

    We present observational evidence for the inhibition of bar formation in dispersion-dominated (dynamically hot) galaxies by studying the relationship between galactic structure and host galaxy kinematics in a sample of 257 galaxies between 0.1 $<$ z $\\leq$ 0.84 from the All-Wavelength Extended Groth Strip International Survey (AEGIS) and the Deep Extragalactic Evolutionary Probe 2 (DEEP2) survey. We find that bars are preferentially found in galaxies that are massive and dynamically cold (rotation-dominated) and on the stellar Tully-Fisher relationship, as is the case for barred spirals in the local Universe. The data provide at least one explanation for the steep ($\\times$3) decline in the overall bar fraction from z=0 to z=0.84 in L$^*$ and brighter disks seen in previous studies. The decline in the bar fraction at high redshift is almost exclusively in the lower mass (10 $<$ log M$_{*}$(\\Msun)$<$ 11), later-type and bluer galaxies. A proposed explanation for this "downsizing" of the bar formation ...

  3. Preparation of a Breadfruit Flour Bar

    Directory of Open Access Journals (Sweden)

    Carmen L. Nochera

    2016-05-01

    Full Text Available Breadfruit is a nutritious, high energy food with a low quantity of protein but excellent protein quality. It has the potential to be developed into desired products which will help increase its utilization and add value to the crop. The overall purposes of this investigation were to develop a portable, nutritious, ready-to-eat breadfruit product (bar, test the sensory qualities of the product, and evaluate the nutritional properties of the product. Flour made from the Micronesian variety, Meinpadahk (Artocarpus altilis × Artocarpus mariannensis, was utilized for the development of the breadfruit bar. Breadfruit is a rich source of fiber, vitamins such as vitamin C, minerals such as potassium, and phytochemicals such as flavonoids. Nutritional labeling indicates that the breadfruit bar is high in carbohydrates and low in fat, and sensory evaluation indicates that 81% of the panelists found the bar acceptable while 19% disliked the bar. The breadfruit bar can provide an appealing and inexpensive gluten-free food source based on locally available breadfruit.

  4. PRODUCCIÓN DE BIODIESEL A PARTIR DE MICROALGAS: PARÁMETROS DEL CULTIVO QUE AFECTAN LA PRODUCCIÓN DE LÍPIDOS Biodiesel Production from Microalgae: Cultivation Parameters that Affect Lipid Production

    Directory of Open Access Journals (Sweden)

    MARTHA TRINIDAD ARIAS PEÑARANDA

    2013-04-01

    Full Text Available Las microalgas poseen la capacidad para mitigar las emisiones de CO2 y producir lípidos, por lo que se consideran con potencial para la obtención de biocombustibles de tercera generación. La presente revisión proporciona información actualizada de la influencia de las condiciones de cultivo, sobre la obtención de lípidos con una productividad elevada y perfil adecuado para la producción de biodiesel, se proporciona una síntesis de resultados de investigaciones realizadas en los últimos 13 años en diversas partes del mundo. En la literatura consultada, los autores concluyen que aunque el comportamiento de las microalgas ante condiciones de estrés fisiológico es variable entre especies; la limitación de nutrientes especialmente nitrógeno y fósforo, asociado al crecimiento heterotrófico o a altas intensidades luminosas en fototrofía se consideran como las estrategias más eficientes para incrementar el contenido de lípidos en las microalgas, en particular de triglicéridos constituidos por ácidos grasos saturados y monoinsaturados, ideales para la producción de biodiesel. De igual forma, señalan que la presencia de pequeñas cantidades de CO2 y la cosecha de la biomasa en la fase estacionaria de crecimiento, incrementan el contenido de lípidos y disminuyen el número de insaturaciones de los ácidos grasos que lo conforman.The microalgae have the capacity to mitigate CO2 emissions and to produce lipids, which are considered with potential to obtain third-generation biofuel. This review provides updated information of the influence of culture conditions on the lipids production with high productivity and profile suitable for the biodiesel production. This document presents a compilation of research conclusions over the last 13 years around the world. In the literature consulted, the authors conclude that although the behavior of microalgae at physiological stress conditions, varies between species; the nutrients limitation

  5. Physical and numerical investigations of channel bar response to hydrograph form

    Science.gov (United States)

    Kenworthy, M.; Yager, E.; Yarnell, S. M.; Merritt, D.

    2013-12-01

    Physical and numerical modeling of river channel morphology often consider the influence of a single discharge or a series of individual discharges assumed to be in normal, steady conditions. However, the rate of change between these discharges may also affect channel morphology. Rapid flooding has been linked to poorly sorted, less armored beds compared to more gradual floods, but the influence on morphology is rarely considered. In addition, installation of vegetation is common in restoration projects though it is not always clear how this will impact morphological features such as bars. Here we present results from a set of flume experiments and 2D modeling designed to investigate the influence of hydrograph shape and vegetation on the morphology of a forced bar in sand-bed channel. Flume experiments were conducted in the Outdoor Stream Lab at Saint Anthony Falls Laboratory, Minneapolis, MN. We ran three falling limb only hydrographs with different recession rates (10, 30, and 70%). Minimum discharge, total volumetric water discharge, and estimated sediment transport capacity were held within 10% between runs. The ratio of sediment supply to estimated transport capacity was also held constant at all times. The 10% run peaked at 150 L/s, while the 30% and 70% runs peaked at 284 L/s. The 30 and 70% runs were repeated with vegetation (Juncus and Carex) that mimicked vegetation established at approximately bankful height. Similar initial conditions for all runs were established by running the flume to equilibrium at constant flow and feed rates. Detailed bar topography/bathymetry data were collected before, during, and following each run. Bar morphology at the conclusion of recession hydrographs indicated that bar development declines as recession rate increases. Both with and without vegetation, the faster recessions resulted in bar morphology that was less distinct. This observation is supported by bar-top widths and areas that both declined as recession rate

  6. $\\bar d - \\bar u$ asymmetry in the proton in chiral effective theory

    Energy Technology Data Exchange (ETDEWEB)

    Salamu, Yusupujiang [Institute of High Energy Physics, CAS, Beijing (China); Ji, Chueng -Ryong [North Carolina State Univ., Raleigh, NC (United States); Melnitchouk, W. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Wang, P. [Institute of High Energy Physics, Beijing (China); Theoretical Physics Center for Science Facilities, CAS, Beijing (China)

    2015-03-25

    We compute the $\\bar d - \\bar u$ asymmetry in the proton in chiral effective theory, including both nucleon and Δ degrees of freedom, within both relativistic and heavy baryon frameworks. In addition to the distribution at $x>0$, we estimate the correction to the integrated asymmetry arising from zero momentum contributions from pion rainbow and bubble diagrams at $x=0$, which have not been accounted for in previous analyses. In conclusion, we find that the empirical $x$ dependence of $\\bar d - \\bar u$ as well as the integrated asymmetry can be well reproduced in terms of a transverse momentum cutoff parameter.

  7. Lipid Chaperones and Metabolic Inflammation

    Directory of Open Access Journals (Sweden)

    Masato Furuhashi

    2011-01-01

    Full Text Available Over the past decade, a large body of evidence has emerged demonstrating an integration of metabolic and immune response pathways. It is now clear that obesity and associated disorders such as insulin resistance and type 2 diabetes are associated with a metabolically driven, low-grade, chronic inflammatory state, referred to as “metaflammation.” Several inflammatory cytokines as well as lipids and metabolic stress pathways can activate metaflammation, which targets metabolically critical organs and tissues including adipocytes and macrophages to adversely affect systemic homeostasis. On the other hand, inside the cell, fatty acid-binding proteins (FABPs, a family of lipid chaperones, as well as endoplasmic reticulum (ER stress, and reactive oxygen species derived from mitochondria play significant roles in promotion of metabolically triggered inflammation. Here, we discuss the molecular and cellular basis of the roles of FABPs, especially FABP4 and FABP5, in metaflammation and related diseases including obesity, diabetes, and atherosclerosis.

  8. Dietary lipid sources affect freshwater catfish jundiá, Rhamdia quelen, survival, when challenged with Aeromonas hydrophila - doi: 10.4025/actascianimsci.v35i4.19617

    Directory of Open Access Journals (Sweden)

    Rodrigo Javier Vargas

    2013-10-01

    Full Text Available The immune modulatory activity of diet long chain polyunsaturated fatty acids in fish has been previously demonstrated, although results for freshwater species are controversial.  This study evaluates the effect of different dietary lipids on freshwater catfish jundiá, Rhamdia quelen, survival and its non-specific response (phagocytosis after being inoculated with the pathogen  Aeromonas hydrophila. Five diets were offered to jundiá fingerlings during 150 days prior to challenge: cod liver oil (FO, sunflower oil (SO, linseed oil (LO, canola oil (CO and coconut oil (CNO. Accumulated mortality was significantly lower in fish fed FO and CNO diets and higher in fish fed LO. In spite of the highest values observed for phagocytotic activity in CNO-fed fish (50.0 + 12.7% and in FO-fed fish (45.0 + 10.5% when compared to those fed other diets, no significant differences in phagocytosis were reported.  Results show the relevance of a balanced dietary lipid source with adequate concentrations of n-3 and n-6 series of fatty acids to prevent mortality after pathogen challenge.   

  9. Cultural Factors Related to Smoking in San Francisco's Irish Bars

    Science.gov (United States)

    Satterlund, Travis D.; Antin, Tamar M. J.; Lee, Juliet P.; Moore, Roland S.

    2009-01-01

    California's Smoke-Free Workplace Act was extended to include bars in 1998. While the majority of bars in the state have become smoke free, in many bars patrons and staff continue to smoke despite the law. The authors present findings from a study which assessed cultural factors related to continued smoking in bars in the city of San Francisco. In…

  10. 21 CFR 886.1650 - Ophthalmic bar prism.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ophthalmic bar prism. 886.1650 Section 886.1650...) MEDICAL DEVICES OPHTHALMIC DEVICES Diagnostic Devices § 886.1650 Ophthalmic bar prism. (a) Identification. An ophthalmic bar prism is a device that is a bar composed of fused prisms of gradually...

  11. Evidence for the existence of $u d \\bar{b} \\bar{b}$ and the non-existence of $s s \\bar{b} \\bar{b}$ and $c c \\bar{b} \\bar{b}$ tetraquarks from lattice QCD

    CERN Document Server

    Bicudo, Pedro; Peters, Antje; Wagenbach, Björn; Wagner, Marc

    2015-01-01

    We combine lattice QCD results for the potential of two static antiquarks in the presence of two quarks $q q$ of finite mass and quark model techniques to study possibly existing $q q \\bar{b} \\bar{b}$ tetraquarks. While there is strong indication for a bound four-quark state for $q q = (ud-du) / \\sqrt{2}$, i.e. isospin $I=0$, we find clear evidence against the existence of corresponding tetraquarks with $q q \\in \\{ uu , (ud+du) / \\sqrt{2} , dd \\}$, i.e. isospin $I=1$, $q q = s s$ and $q q = c c$.

  12. Effect of Load on Peak Power of the Bar, Body and System during the Deadlift

    Directory of Open Access Journals (Sweden)

    Justin A. Blatnik, Courtney L. Goodman, Christopher R. Capps, Olumide O. Awelewa, Travis N. Triplett, Travis M. Erickson, Jeffery M. McBride

    2014-09-01

    Full Text Available The purpose of this investigation was to examine how load would affect peak power (PP of the bar, body and system (bar + body during the deadlift. Eight healthy males (age = 22.00 ± 2.38 years; height = 1.80 ± 0.05 m; body mass = 88.97 ± 14.88 kg; deadlift one repetition maximum [1RM] = 203.44 ± 21.59 kg, 1RM/BM = 2.32 ± 0.31 with a minimum of 2 years’ resistance training experience and a deadlift 1RM over 1.5 times their bodyweight participated in the investigation. During the first session, anthropometric data were recorded and a 1RM deadlift was obtained from the participants. During the second session, participants performed two repetitions at intensities of 30, 40, 50, 60, 70, 80 and 90% of their 1RM in a randomized order. Three-dimensional videography with a force plate was used for data collection and analysis. Peak force (PF, peak velocity (PV, an d PP were calculated for the bar, body, and system (bar + body during the deadlift. PP occurred at 50%, 30%, and 70% of 1RM for the bar, body, and system, respectively. The optimal loading for the deadlift exercise may vary depending on the desired stimulus and whether the bar, body, or system variables are of most interest.

  13. The effects of bar-spiral coupling on stellar kinematics in the Galaxy

    CERN Document Server

    Monari, Giacomo; Siebert, Arnaud; Grand, Robert J J; Kawata, Daisuke; Boily, Christian

    2016-01-01

    We investigate models of the Milky Way disc taking into account simultaneously the bar and a two-armed quasi-static spiral pattern. Away from major resonance overlaps, the mean stellar radial motions in the plane are essentially a linear superposition of the isolated effects of the bar and spirals. Thus, provided the bar is strong enough, even in the presence of spiral arms, these mean radial motions are predominantly affected by the Galactic bar for large scale velocity fluctuations. This is evident when comparing the peculiar line-of-sight velocity power spectrum of our coupled models with bar-only models. However, we show how forthcoming spectroscopic surveys could disentangle bar-only non-axisymmetric models of the Galaxy from models in which spiral arms have a significant amplitude. We also point out that overlaps of low-order resonances are sufficient to enhance stellar churning within the disc, even when the spirals amplitude is kept constant. Nevertheless, for churning to be truly non-local, stronger ...

  14. On the Relation between Spector's Bar Recursion and Modified Bar Recursion

    DEFF Research Database (Denmark)

    Oliva, Paulo Borges

    2002-01-01

    We introduce a variant of Spector's Bar Recursion in finite types to give a realizability interpretation of the classical axiom of dependent choice allowing for the extraction of witnesses from proofs of Sigma_1 formulas in classical analysis. We also give a bar recursive definition of the fan fu...

  15. Heavy-flavored tetraquark states with the $QQ\\bar{Q}\\bar{Q}$ configuration

    CERN Document Server

    Wu, Jing; Chen, Kan; Liu, Xiang; Zhu, Shi-Lin

    2016-01-01

    In the framework of the color-magnetic interaction, we systematically investigate the mass spectrum of the tetraquark states composed of four heavy quarks with the $QQ\\bar Q\\bar Q$ configuration in this work. We also discuss their strong decay patterns, which shall be helpful to the experimental search for these exotic states.

  16. Bar Admission--Default on Student Loan Warrants Denial of Admission to Minnesota Bar.

    Science.gov (United States)

    William Mitchell Law Review, 1980

    1980-01-01

    The Minnesota Supreme Court upheld a decision that student loan default, and subsequent dismissal through bankruptcy, is sufficient reason to deny a law student's bar admission. The bar's requirement of good moral character was interpreted as financial integrity in the Gahan case. (MSE)

  17. B → Dlν form factors and the determination of vertical bar Vcb vertical bar

    International Nuclear Information System (INIS)

    The zero recoil limit of the B → Dlν form factors is calculated on the lattice, which provides a model-independent determination of vertical bar Vcb vertical bar. Considering a ratio of form factors, in which the bulk of statistical and systematic errors cancel, we obtain a precise result both for h+(1) and for h-(1)

  18. The influence of the environment on bar formation

    OpenAIRE

    Mendez-Abreu, J.; Aguerri, J. A. L.; Zarattini, S.; Sanchez-Janssen, R.; Corsini, E. M.

    2009-01-01

    Galaxy mergers and interactions are mechanisms which could drive the formation of bars. Therefore, we could expect that the fraction of barred galaxies increases with the local density. Here we show the first results of an extensive search for barred galaxies in different environments. We conclude that the bar fraction on bright (L>L*) field, Virgo, and Coma cluster galaxies is compatible. These results point towards an scenario where the formation and/or evolution of bars depend mostly on in...

  19. Challenges implementing bar-coded medication administration in the emergency room in comparison to medical surgical units.

    Science.gov (United States)

    Glover, Nancy

    2013-03-01

    Bar-coded medication administration has been successfully implemented and utilized to decrease medication errors at a number of hospitals in recent years. The purpose of this article was to discuss the varying success in utilization of bar-coded medication administration on medical-surgical units and in the emergency department. Utilization reports were analyzed to better understand the challenges between the units. Many factors negatively impacted utilization in the emergency department, including the inability to use bar-coded medication administration for verbal orders or to document medications distributed by the prescribing providers, unique aspects of emergency department nursing workflow, additional steps to chart when using bar-coded medication administration, and alert fatigue. Hardware problems affected all users. Bar-coded medication administration in its current form is more suitable for use on medical-surgical floors than in the emergency department. New solutions should be developed for bar-coded medication administration in the emergency department, keeping in mind requirements to chart medications when there is no order in the system, document medications distributed by prescribing providers, adapt to unpredictable nursing workflow, minimize steps to chart with bar-coded medication administration, limit alerts to those that are clinically meaningful, and choose reliable hardware with adequate bar-code scanning capability. PMID:23321481

  20. CP Asymmetries in bar B -> bar K* (-> bar K pi) l+ l- and Untagged bar B_s,B_s -> phi (-> K+ K-) l+ l- Decays at NLO

    CERN Document Server

    Bobeth, Christoph; Piranishvili, Giorgi

    2008-01-01

    The decay bar B -> bar K* (-> bar K pi) l+ l- offers great opportunities to explore the physics at and above the electroweak scale by means of an angular analysis. We investigate the physics potential of the seven CP asymmetries plus the asymmetry in the rate, working at low dilepton mass using QCD factorization at next-to leading order (NLO). The b ->s CP asymmetries are doubly Cabibbo-suppressed \\lesssim 1 % in the Standard Model and its extensions where the CKM matrix is the only source of CP violation. Three CP asymmetries are T-odd, and can be O(1) in the presence of non-standard CP violation. The T-even asymmetries can reach O(0.1), limited by the small strong phases in the large recoil region. We furthermore point out an easy way to measure CP phases from time-integrated, untagged bar B_d, B_d -> K* (-> K0 pi0) l+ l- and bar B_s,B_s -> phi (-> K+ K-) l+ l- decays. Analyses of these CP asymmetries can rule out, or further support the minimal description of CP violation through the CKM mechanism. Experim...

  1. Tidally induced bars of galaxies in clusters

    CERN Document Server

    Lokas, Ewa L; del Pino, Andres; Sybilska, Agnieszka; Athanassoula, E; Semczuk, Marcin; Gajda, Grzegorz; Fouquet, Sylvain

    2016-01-01

    Using N-body simulations we study the formation and evolution of tidally induced bars in disky galaxies in clusters. Our progenitor is a massive, late-type galaxy similar to the Milky Way, composed of an exponential disk and an NFW dark matter halo. We place the galaxy on four different orbits in a Virgo-like cluster and evolve it for 10 Gyr. As a reference case we also evolve the same model in isolation. Tidally induced bars form on all orbits soon after the first pericenter passage and survive until the end of the evolution. They appear earlier, are stronger, longer and have lower pattern speeds for tighter orbits. Only for the tightest orbit the properties of the bar are controlled by the orientation of the tidal torque from the cluster at pericenters. The mechanism behind the formation of the bars is the angular momentum transfer from the galaxy stellar component to its halo. All bars undergo extended periods of buckling instability that occur earlier and lead to more pronounced boxy/peanut shapes when th...

  2. Bar code application to nuclear material accountancy

    International Nuclear Information System (INIS)

    For the purpose of efficient implementation of IAEA safeguards inspection, operators ought to prepare the information which is related to the strata for flow verification in a timely manner, such as physical inventory listing and summary of the fuel bundles. Today the use of bar code technique in tracing of products related data or counting number of items has been more and more applied to many facets of industry. From these points of view, the Japan Nuclear Fuel Company (NF) has been developing JNF Total Bar Code System. Now JNF has established an on-line input system of the fuel bundle accountability data by use of the bar code system to quickly prepare the information necessary for the inspection. As the first step, JNF implemented this bar code system at the flow verification to prepare physical inventory summary and location map of the fuel bundles in the storage. This paper reports that as a result of this, NF confirmed that this bar code system made it possible to input easily and quickly nuclear material accountancy information, and therefore this system is utilized as an effective and efficient measure of timely preparation for the inspection

  3. Bar code usage in nuclear materials accountability

    International Nuclear Information System (INIS)

    The age old method of physically taking an inventory of materials by listing each item's identification number has lived beyond its usefulness. In this age of computerization, which offers the local grocery store a quick, sure, and easy means to inventory, it is time for nuclear materials facilities to automate accountability activities. The Oak Ridge Y-12 Plant began investigating the use of automated data collection devices in 1979. At that time, bar code and optical-character-recognition (OCR) systems were reviewed with the purpose of directly entering data into DYMCAS (Dynamic Special Nuclear Materials Control and Accountability System). Both of these systems appeared applicable; however, other automated devices already employed for production control made implementing the bar code and OCR seem improbable. However, the DYMCAS was placed on line for nuclear material accountability, a decision was made to consider the bar code for physical inventory listings. For the past several months a development program has been underway to use a bar code device to collect and input data to the DYMCAS on the uranium recovery operations. Programs have been completed and tested, and are being employed to ensure that data will be compatible and useful. Bar code implementation and expansion of its use for all nuclear material inventory activity in Y-12 is presented

  4. Bar code usage in nuclear materials accountability

    International Nuclear Information System (INIS)

    The Oak Ridge Y-12 Plant began investigating the use of automated data collection devices in 1979. At this time, bar code and optical-character-recognition (OCR) systems were reviewed with the purpose of directly entering data into DYMCAS (Dynamic Special Nuclear Materials Control and Accountability System). Both of these systems appeared applicable, however, other automated devices already employed for production control made implementing the bar code and OCR seem improbable. However, the DYMCAS was placed on line for nuclear material accountability, a decision was made to consider the bar code for physical inventory listings. For the past several months a development program has been underway to use a bar code device to collect and input data to the DYMCAS on the uranium recovery operations. Programs have been completed and tested, and are being employed to ensure that data will be compatible and useful. Bar code implementation and expansion of its use for all nuclear material inventory activity in Y-12 is presented

  5. Warp evidences in precessing galactic bar models

    CERN Document Server

    Sanchez-Martin, Patricia; Masdemont, Josep J

    2016-01-01

    Most galaxies have a warped shape when they are seen from an edge-on point of view. The reason for this curious form is not completely known so far and in this work we apply dynamical system tools to contribute to its explanation. Starting from a simple, but realistic, model formed by a bar and a disc, we study the effect produced by a small misalignment between the angular momentum of the system and its angular velocity. To this end, a precession model is developed and considered, assuming that the bar behaves like a rigid body. After checking that the periodic orbits inside the bar keep being the skeleton of the inner system, even after inflicting a precession to the potential, we compute the invariant manifolds of the unstable periodic orbits departing from the equilibrium points at the ends of the bar to get evidences of their warped shapes. As it is well known, the invariant manifolds associated with these periodic orbits drive the arms and rings of barred galaxies and constitute the skeleton of these bu...

  6. Partial entrainment of gravel bars during floods

    Science.gov (United States)

    Konrad, C.P.; Booth, D.B.; Burges, S.J.; Montgomery, D.R.

    2002-01-01

    Spatial patterns of bed material entrainment by floods were documented at seven gravel bars using arrays of metal washers (bed tags) placed in the streambed. The observed patterns were used to test a general stochastic model that bed material entrainment is a spatially independent, random process where the probability of entrainment is uniform over a gravel bar and a function of the peak dimensionless shear stress ??*0 of the flood. The fraction of tags missing from a gravel bar during a flood, or partial entrainment, had an approximately normal distribution with respect to ??*0 with a mean value (50% of the tags entrained) of 0.085 and standard deviation of 0.022 (root-mean-square error of 0.09). Variation in partial entrainment for a given ??*0 demonstrated the effects of flow conditioning on bed strength, with lower values of partial entrainment after intermediate magnitude floods (0.065 entrainment was approximately uniform over a gravel bar during individual floods and independent from flood to flood, regions of preferential stability and instability emerged at some bars over the course of a wet season. Deviations from spatially uniform and independent bed material entrainment were most pronounced for reaches with varied flow and in consecutive floods with small to intermediate magnitudes.

  7. Results from the KARMEN nu-bar submu -> nu-bar sub e neutrino oscillation search

    CERN Document Server

    Eitel, K

    1999-01-01

    The neutrino experiment KARMEN is situated at the beam stop neutrino source ISIS. It provides nu submu's, nu sub e 's and nu-bar's in equal intensities from the pi sup + -mu sup + -decay at rest (DAR). The oscillation channel nu-bar submu -> nu-bar sub e is investigated in the appearance mode with a 56 t liquid scintillation calorimeter at a mean distance of 17.7 m from the nu-source looking for p (nu-bar sub e , e sup +) n reactions. In the data collected through 1997 and 1998 no potential oscillation event was observed. Using a unified approach to small signals as recommended by the PDG, this leads to an upper limit for the mixing angle of sin sup 2 (2 THETA) nu-bar sub e evidence.

  8. A lipid transfer protein that transfers lipid

    OpenAIRE

    Levine, T. P.

    2007-01-01

    Very few lipid transfer proteins (LTPs) have been caught in the act of transferring lipids in vivo from a donor membrane to an acceptor membrane. Now, two studies (Halter, D., S. Neumann, S. M. van Dijk, J. Wolthoorn, A. M. de Maziere, O.V. Vieira, P. Mattjus, J. Klumperman, G. van Meer, and H. Sprong. 2007. J. Cell Biol. 179: 101 115; D'Angelo, G., E. Polishchuk, G. D. Tullio, M. Santoro, A. D. Campli, A. Godi, G. West, J. Bielawski, C.C. Chuang, A. C. van der Spoel, et al. 2007. Nature. 449...

  9. DARK MATTER HALOS AND EVOLUTION OF BARS IN DISK GALAXIES: VARYING GAS FRACTION AND GAS SPATIAL RESOLUTION

    International Nuclear Information System (INIS)

    We conduct numerical experiments by evolving gaseous/stellar disks embedded in live dark matter halos aiming at quantifying the effect of gas spatial resolution and gas content on the bar evolution. Three model sequences have been constructed using different resolutions, and the gas fraction has been varied along each sequence within the range of fg = 0%-50%, but keeping the disk and halo properties unchanged. We find that the spatial resolution becomes important with an increase in the gas content. For the higher resolution model sequences, we observe a bimodal behavior in the bar evolution with respect to the gas fraction, especially during the secular phase of this evolution. The switch from the gas-poor to gas-rich behavior is abrupt and depends on the resolution used, being reasonably confined to fg ∼ 5%-12%. The diverging evolution has been observed in nearly all basic parameters characterizing bars, such as the bar strength, central mass concentration, bar vertical buckling amplitude, bar size, etc. We find that the presence of the gas component severely limits the bar growth and affects its pattern speed evolution. Gas-poor models display rapidly decelerating bars, while gas-rich models exhibit bars with constant or even slowly accelerating tumbling. We also find that the gas-rich models have bar corotation (CR) radii within the disk at all times, in contrast with gas-poor and purely stellar disks. In addition, the CR-to-bar size ratio is less than 2 for gas-rich models. Next, we have confirmed that the disk angular momentum within the CR remains unchanged in the gas-poor models, as long as the CR stays within the disk, but experiences a sharp drop before leveling off in the gas-rich models. Finally, we discuss a number of observed correlations between various parameters of simulated bars, such as between the bar sizes and the gas fractions, between the bar strength and the buckling amplitude, and between the bar strength and its size, etc.

  10. Environmentally friendly analysis of emerging contaminants by pressurized hot water extraction-stir bar sorptive extraction-derivatization and gas chromatography-mass spectrometry

    OpenAIRE

    Pintado-Herrera, Marina G.; González-Mazo, Eduardo; Lara-Martín, Pablo A.

    2013-01-01

    This work describes the development, optimiza- tion, and validation of a new method for the simultaneous determination of a wide range of pharmaceuticals (beta- blockers, lipid regulators ... ) and personal care products (fragrances, UV filters, phthalates ... ) in both aqueous and solid environmental matrices. Target compounds were extracted from sediments using pressurized hot water ex- traction followed by stir bar sorptive extraction. The first stage wa...

  11. A new magnetic bar code system based on a magnetic anisotropy detection (abstract)

    Science.gov (United States)

    Sasada, I.; Watanabe, N.

    1996-04-01

    Magnetic bar codes can be used in unclean environments, where widely used optical bar code systems cannot be applied. Readout system for magnetic bar codes can also be made much simpler than optical ones. A new magnetic bar code system is proposed, in which binary information is coded in the sign of tilted angles of magnetic strips from a given standard direction. This scheme is unique compared to the conventional optical bar code, where width or space of the parallel pattern carries information, or an already reported magnetic bar code, where cross sectional shapes of pattern engraved in a ferromagnetic body carries information. Each of the magnetic strips brings about magnetic anisotropy due to its shape effect, hence angular dependent permeability in the proximity of the strip. The sign of the tilted angle of each magnetic strip is detected inductively through the angular dependent permeability by using a magnetic pickup head with a pair of cross-coupled figure-eight coils, where the sign of mutual inductance between the primary and the secondary figure-eight coil has one to one relationship to the sign of the tilted angle. Because the detection of the tilted angle is independent of scanning speed, variation in the scanning speed of the readout head does not affect the performance. In our preliminary study, the proposed magnetic bar code system was examined using pickup head consisting of a pair of cross-coupled 10-turn figure-eight coils which was embedded in a rectangular ferrite rod with cross-shape groove on the top surface of 6.5×3 mm dimension. The head was made thinner in the scanning direction to allow dense alignment of the pattern. Two kinds of pattern were made: the one was by aligning short amorphous wires (5 mm in length and 120 μm in diameter) on the plastic film and the other by using a thin (10 μm in thickness) copper film with tilted slits backed by an amorphous ribbon. These samples of magnetic bar code patterns were scanned with lift-off of

  12. Development of a miniature tensile Kolsky bar for dynamic testing of thin films

    Science.gov (United States)

    Paul, Jastin V.

    Mechanical properties such as yield stress and ultimate strength are most commonly obtained under quasi-static (strain rate of 10--4 s--1) loading conditions Materials such as metals, ceramics, and polymers may exhibit significant changes in mechanical response when subjected to high strain rate (102 --105 per second) conditions. The loading rate or strain rate can affect the material properties such as elastic modulus, yield strength, work hardening, and ductility. To ensure product quality and reliability under impact conditions, the mechanical responses of materials under dynamic loading conditions must be characterized. A Kolsky bar is a tool that can be used to study the uniaxial compressive constitutive behavior of materials under high strain rates. The goal of this thesis is to develop a miniature Tensile Kolsky bar that can be used to test materials with thickness on the order of 200 micrometers (thin foils). The system consists of a cylindrical launch tube with an internal striker, a rectangular incident bar and a transmitted bar. The specimen is held in pockets that were milled directly into the incident and transmitted bar. The rectangular incident and transmitted bars facilitate specimen and strain gage mounting. The rectangular section also provides a reduced cross sectional bar area compared to a bar of circular cross section with diameter equivalent to the width of the rectangular bar, which increases the system sensitivity. This thesis presents the detailed description of the miniature Kolsky bar device, specimen geometry, diagnostic techniques and different calibration and validation techniques used for developing the system. The Kolsky bar setup was used to test 99.9 percent pure magnesium at two different strain rates (5000 and 10000 per second). Specimens were cut from billets processed via the 4Bc equal channel angular extrusion route and were tested in three different directions: extrusion, longitudinal and transverse. The results from the

  13. Imaging of physeal bars in children

    Energy Technology Data Exchange (ETDEWEB)

    Wang, David C. [Massachusetts General Hospital and Harvard Medical School, Department of Radiology, Boston, MA (United States); Deeney, Vincent; Roach, James W. [Children' s Hospital of Pittsburgh of UPMC, Department of Orthopedics, Pittsburgh, PA (United States); Shah, Amisha J. [Children' s Hospital of Pittsburgh of UPMC, Department of Radiology, Pittsburgh, PA (United States)

    2015-08-15

    The growth plate, also known as the physis or epiphyseal plate, is essential for longitudinal growth of bones in the immature skeleton. A variety of insults to the growth plate from trauma to infection to idiopathic causes can lead to physeal bar formation, an interruption in normal growth plate cartilage, where a bony or fibrous bridge develops between the metaphysis and epiphysis. This bridge restricts subsequent bone growth, leading to limb shortening and/or angular deformities. Early recognition of the presence of a physeal bar can help direct appropriate surgical management to restore linear growth of the bone. (orig.)

  14. Jazz Chants Born in a Piano Bar

    Directory of Open Access Journals (Sweden)

    Caroline Graham

    2010-01-01

    Full Text Available When I first arrived in New York in the late sixties, I began teaching ESL at New York University. I didn`t really think of teaching as a profession for me. I just thought it would pay the rent so I could do what I really wanted to do which was to sing and play ragtime piano in the piano bars. When I got my first piano job in an Irish Bar it was uptown, far away from NYU so I didn`t feel it was necessary to mention this night job to my boss.

  15. BAR-MOM Code and Its Application

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    BAR-MOM [1,2] code to calculate the height of the fission barrier Bf, the energy of the ground state, the compound nucleus stability by limit with respect to fission, i.e., the angular momentum(the spin value) Lmax at which the fission barrier disappears, the three principal axis moments of inertia at saddle point for a certain nucleus with atomic number Z, atomic mass number and angular momentum L for 19BAR-MOM code to include the results for Z≥102[3] by using more recent parameterization of the Thomas Fermi fission

  16. B Counting at BaBar

    Energy Technology Data Exchange (ETDEWEB)

    McGregor, Grant Duncan

    2008-12-16

    In this thesis we examine the method of counting B{bar B} events produced in the BABAR experiment. The original method was proposed in 2000, but improvements to track reconstruction and our understanding of the detector since that date make it appropriate to revisit the B Counting method. We propose a new set of cuts designed to minimize the sensitivity to time-varying backgrounds. We find the new method counts B{bar B} events with an associated systematic uncertainty of {+-} 0.6%.

  17. Sine-Bar Attachment For Machine Tools

    Science.gov (United States)

    Mann, Franklin D.

    1988-01-01

    Sine-bar attachment for collets, spindles, and chucks helps machinists set up quickly for precise angular cuts that require greater precision than provided by graduations of machine tools. Machinist uses attachment to index head, carriage of milling machine or lathe relative to table or turning axis of tool. Attachment accurate to 1 minute or arc depending on length of sine bar and precision of gauge blocks in setup. Attachment installs quickly and easily on almost any type of lathe or mill. Requires no special clamps or fixtures, and eliminates many trial-and-error measurements. More stable than improvised setups and not jarred out of position readily.

  18. Track Finding Efficiency in BaBar

    CERN Document Server

    Allmendinger, T; Brown, D N; Choi, H; Christ, S; Covarelli, R; Davier, M; Denig, A G; Fritsch, M; Hafner, A; Kowalewski, R; Long, O; Lutz, A M; Martinelli, M; Muller, D R; Nugent, I M; Pegna, D Lopes; Purohit, M V; Prencipe, E; Roney, J M; Simi, G; Solodov, E P; Telnov, A V; Varnes, E; Waldi, R; Wang, W F; White, R M

    2012-01-01

    We describe several studies to measure the charged track reconstruction efficiency and asymmetry of the BaBar detector. The first two studies measure the tracking efficiency of a charged particle using $\\tau$ and initial state radiation decays. The third uses the $\\tau$ decays to study the asymmetry in tracking, the fourth measures the tracking efficiency for low momentum tracks, and the last measures the reconstruction efficiency of $K_S^0$ particles. The first section also examines the stability of the measurements vs BaBar running periods.

  19. The Disability Dilemma: A Skeptical Bench & Bar

    OpenAIRE

    Wendy F. Hensel

    2008-01-01

    The legal profession is no stranger to the bias and prejudice present in American society. Members of the bar have been shown to engage in both conscious and subconscious sexism and racism, posing challenges to the profession as the profile of those practicing law has changed over the last several decades to admit increasing numbers of women and minorities.1 Nevertheless, it is notable that few, if any, members of the bar today would question openly whether women or people of color have the a...

  20. Brouwer’s Real Thesis on Bars

    OpenAIRE

    Veldman, W.H.M.

    2006-01-01

    L.E.J. Brouwer made a mistake in the formulation of his famous bar theorem, as was pointed out by S.C. Kleene. By repeating this mistake several times, Brouwer has caused confusion. We consider the assumption underlying his bar theorem, calling it Brouwer’s Thesis. This assumption is not refuted by Kleene’s example and we use it to obtain a conclusion different from Brouwer’s. Thus we come to support a view first expressed and defended by E. Martino and P. Giaretta in [Martino 1981]. We also ...

  1. Fibered Multilinks and singularities $f \\bar g$

    OpenAIRE

    Pichon, Anne; Seade, José

    2005-01-01

    In this article we extend Milnor's fibration theorem for complex singularities to the case of singularities $f \\bar g:(X,P) \\to (C,0))$ defined on a complex analytic singularity germ $(X,P)$, with $f, g$ holomorphic and $f \\bar g$ having an isolated critical value at $0 \\in C$. This can also be regarded as a result for meromorphic germs. Then we strenghten this fibration theorem when $X$ has complex dimension 2, obtaining a fibration theorem for multilinks that extends previous work by Pichon...

  2. Forming Double-barred Galaxies From Dynamically Cool Inner Disks

    CERN Document Server

    Du, Min; Debattista, Victor P

    2015-01-01

    About one third of early-type barred galaxies host small-scale secondary bars. The formation and evolution of such double-barred galaxies remain far from being well understood. In order to understand the formation of such systems, we explore a large parameter space of isolated pure-disk simulations. We show that a dynamically cool inner disk embedded in a hotter outer disk can naturally generate a steady secondary bar while the outer disk forms a large-scale primary bar. The independent bar instabilities of inner and outer disks result in long-lived double-barred structures whose dynamical properties are comparable with observations. This formation scenario indicates that the secondary bar might form from the general bar instability, the same as the primary bar. Under some circumstances, the interaction of the bars and the disk leads to the two bars aligning or single, nuclear, bars only. Simulations that are cool enough of the center to experience clump instabilities may also generate steady double-barred ga...

  3. Observation of B+ --> K0bar K+ and B0 --> K0 K0bar

    CERN Document Server

    Aubert, B; Boutigny, D; Couderc, F; Karyotakis, Yu; Lees, J P; Poireau, V; Tisserand, V; Zghiche, A; Graugès-Pous, E; Palano, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Gill, M S; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lynch, G; Mir, L M; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, M T; Wenzel, W A; Del, P; Amo Sanchez; Barrett, M; Ford, K E; Harrison, T J; Hart, A J; Hawkes, C M; Watson, A T; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schröder, T; Steinke, M; Boyd, J T; Burke, J P; Cottingham, W N; Walker, D; Asgeirsson, D J; Çuhadar-Dönszelmann, T; Fulsom, B G; Hearty, C; Knecht, N S; Mattison, T S; McKenna, J A; Khan, A; Kyberd, P; Saleem, M; Sherwood, D J; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Bondioli, M; Bruinsma, M; Chao, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M A; Mommsen, R K; Röthel, W; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Long, O; Shen, B C; Wang, K; Zhang, L; Hadavand, H K; Hill, E J; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Nesom, G; Schalk, T; Schumm, B A; Seiden, A; Spradlin, P; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dvoretskii, A; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Ruddick, W O; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Chen, A; Eckhart, E A; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Zeng, Q; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Merkel, J; Petzold, A; Spaan, B; Brandt, T; Klose, V; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Latour, E; Thiebaux, C; Verderi, M; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Contri, R; Lo, M; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Brandenburg, G; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Flack, R L; Nash, J A; Nikolich, M B; Panduro-Vazquez, W; Behera, P K; Chai, X; Charles, M J; Mallik, U; Meyer, N T; Ziegler, V; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gritsan, A V; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Davier, M; Grosdidier, G; Höcker, A; Le Diberder, F R; Lepeltier, V; Lutz, A M; Oyanguren, A; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Stocchi, A; Wang, W F; Wormser, G; Cheng, C H; Lange, D J; Wright, D M; Chavez, C A; Forster, I J; Fry, J R; Gabathuler, E; Gamet, R; George, K A; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; Di Lodovico, F; Menges, W; Sacco, R; Cowan, G; Flächer, H U; Hopkins, D A; Jackson, P S; McMahon, T R; Ricciardi, S; Salvatore, F; Wren, A C; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; Naisbit, M T; Williams, J C; Yi, J I; Chen, C; Hulsbergen, W D; Jawahery, A; Lae, C K; Roberts, D A; Simi, G; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Saremi, S; Stängle, H; Cowan, R; Sciolla, G; Sekula, S J; Spitznagel, M; Taylor, F; Yamamoto, R K; Kim, H; Mclachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Lombardo, V; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; Cavallo, N; De Nardo, Gallieno; Fabozzi, F; Gatto, C; Lista, L; Monorchio, D; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M A; Raven, G; Snoek, H L; Jessop, C P; LoSecco, J M; Allmendinger, T; Benelli, G; Corwin, L A; Gan, K K; Honscheid, K; Hufnagel, D; Jackson, P D; Kagan, H; Kass, R; Rahimi, A M; Regensburger, J J; Ter-Antonian, R; Wong, Q K; Blount, N L; Brau, J E; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; Del, L; Buono; La Vaissière, C de; Hamon, O; Hartfiel, B L; Leruste, P; Malcles, J; Ocariz, J; Roos, L; Therin, G; Gladney, L; Biasini, M; Covarelli, R; Angelini, C; Batignani, G; Bettarini, S; Bucci, F; Calderini, G; Carpinelli, M; Cenci, R; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Haire, M; Judd, D; Wagoner, D E; Biesiada, J; Danielson, N; Elmer, P; Lau, Y P; Lü, C; Olsen, J; Smith, A J S; Telnov, A V; Bellini, F; Cavoto, G; D'Orazio, A; Del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Safai-Tehrani, F; Voena, C; Ebert, M; Schröder, H; Waldi, R; Adye, T; De Groot, N; Franek, B; Olaiya, E O; Wilson, F F; Aleksan, R; Emery, S; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, Witold; Legendre, M; Vasseur, G; Yéche, C; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Berger, N; Claus, R; Coleman, J P; Convery, M R; Cristinziani, M; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Grenier, P; Halyo, V; Hast, C; Hrynóva, T; Innes, W R; Kelsey, M H; Kim, P; Leith, D W G S; Li, S; Luitz, S; Lüth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Müller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Pulliam, T; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Stelzer, J; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Vavra, J; Van Bakel, N; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Burchat, P R; Edwards, A J; Majewski, S A; Petersen, B A; Roat, C; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Ritchie, J L; Satpathy, A; Schilling, C J; Schwitters, R F; Izen, J M; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Dittongo, S; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martínez-Vidal, F; Banerjee, Sw; Bhuyan, B; Brown, C M; Fortin, D; Hamano, K; Kowalewski, R V; Nugent, I M; Roney, J M; Sobie, R J; Back, J J; Harrison, P F; Latham, T E; Mohanty, G B; Pappagallo, M; Band, H R; Chen, X; Cheng, B; Dasu, S; Datta, M; Flood, K T; Hollar, J J; Kutter, P E; Mellado, B; Mihályi, A; Pan, Y; Pierini, M; Prepost, R; Wu, S L; Yu, Z; Neal, H

    2006-01-01

    We report observations of the b --> d penguin-dominated decays B+ --> K0bar K+ and B0 --> K0 K0bar in approximately 350 million Upsilon(4S) --> BBbar decays collected with the BaBar detector. We measure the branching fractions B(B+ --> K0bar K+) = (1.61 +/- 0.44 +/- 0.09) * 10^-6 and B(B0 --> K0 K0bar) = (1.08 +/- 0.28 +/- 0.11) * 10^-6, and the CP-violating charge asymmetry A_{CP}(K0bar K+) = 0.10 +/- 0.26 +/- 0.03. Using a vertexing technique previously employed in several analyses of all-neutral final states containing kaons, we report the first measurement of time-dependent CP-violating asymmetries in B0 --> K0 K0bar, obtaining S = -1.28 +0.80/-0.73 +0.11/-0.16 and C = -0.40 +/- 0.41 +/- 0.06. We also report improved measurements of the branching fraction B(B0 --> K0 pi+) = (23.9 +/- 1.1 +/- 1.0) * 10^-6 and CP-violating charge asymmetry A_{CP}(K0 pi+) = -0.029 +/- 0.039 +/- 0.010.

  4. Lipid Microarray Biosensor for Biotoxin Detection.

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Anup K.; Throckmorton, Daniel J.; Moran-Mirabal, Jose C.; Edel, Joshua B.; Meyer, Grant D.; Craighead, Harold G.

    2006-05-01

    We present the use of micron-sized lipid domains, patterned onto planar substrates and within microfluidic channels, to assay the binding of bacterial toxins via total internal reflection fluorescence microscopy (TIRFM). The lipid domains were patterned using a polymer lift-off technique and consisted of ganglioside-populated DSPC:cholesterol supported lipid bilayers (SLBs). Lipid patterns were formed on the substrates by vesicle fusion followed by polymer lift-off, which revealed micron-sized SLBs containing either ganglioside GT1b or GM1. The ganglioside-populated SLB arrays were then exposed to either Cholera toxin subunit B (CTB) or Tetanus toxin fragment C (TTC). Binding was assayed on planar substrates by TIRFM down to 1 nM concentration for CTB and 100 nM for TTC. Apparent binding constants extracted from three different models applied to the binding curves suggest that binding of a protein to a lipid-based receptor is strongly affected by the lipid composition of the SLB and by the substrate on which the bilayer is formed. Patterning of SLBs inside microfluidic channels also allowed the preparation of lipid domains with different compositions on a single device. Arrays within microfluidic channels were used to achieve segregation and selective binding from a binary mixture of the toxin fragments in one device. The binding and segregation within the microfluidic channels was assayed with epifluorescence as proof of concept. We propose that the method used for patterning the lipid microarrays on planar substrates and within microfluidic channels can be easily adapted to proteins or nucleic acids and can be used for biosensor applications and cell stimulation assays under different flow conditions. KEYWORDS. Microarray, ganglioside, polymer lift-off, cholera toxin, tetanus toxin, TIRFM, binding constant.4

  5. Lectura en barómetro

    OpenAIRE

    Cháfer, Amparo

    2012-01-01

    Elaboración de material digital y recursos en la red para el tercer curso de la titulación de Química y nuevos grados. El objetivo de este vídeo es aprender a medir la presión atmosférica en un barómetro.

  6. High quality joints of copper bus bars

    Directory of Open Access Journals (Sweden)

    Samarjit Bhattacharyya,

    2010-08-01

    Full Text Available Efficient joints in copper bus bar conductors can be made very simply by bolting and clamping. This paper proposes the method to maximize the jointing efficiency in order to eliminate hot spots in switchgears by optimizing the effect of spreading resistance and interface resistance.

  7. The bar coil for NMR tomograph

    International Nuclear Information System (INIS)

    The bar coil (bi-planar) for the NMR tomograph, designed for medical diagnostics, has been described. The tests of coil shown that it generates good homogenous magnetic field in a big volume what results in improving of the signal-to-noise ratio

  8. The BaBar Data Acquisition System

    CERN Document Server

    Scott, I; Grosso, P; Huffer, M E; O'Grady, C; Russell, J J

    1999-01-01

    The BaBar experiment at the Stanford Linear Accelerator Center is designed to perform a search for CP violation by ana-lyzing the decays of a very large sample of B and B(Bar) mesons produced at the high luminosity PEP-II accelerator. The data acquisition system must cope with a sustained high event rate, while supporting real time feature extraction and data compression with minimal dead time. The BaBar data acquisition system is based around a common VME interface to the electronics read-out of the separate detec-tor subsystems. Data from the front end electronics is read into commercial VME processors via a custom "Personality Card" and PCI interface. The commercial CPUs run the Tornado operating system to provide a platform for detector subsystem code to perform the necessary data processing. The data is read out via a non-blocking network switch to a farm of commercial UNIX processors. The current implementation of the BaBar data acquisition sys-tem has been shown to sustain a Level 1 trigger rate of 1.3...

  9. Blast Quantification Using Hopkinson Pressure Bars.

    Science.gov (United States)

    Clarke, Samuel D; Fay, Stephen D; Rigby, Samuel E; Tyas, Andrew; Warren, James A; Reay, Jonathan J; Fuller, Benjamin J; Gant, Matthew T A; Elgy, Ian D

    2016-01-01

    Near-field blast load measurement presents an issue to many sensor types as they must endure very aggressive environments and be able to measure pressures up to many hundreds of megapascals. In this respect the simplicity of the Hopkinson pressure bar has a major advantage in that while the measurement end of the Hopkinson bar can endure and be exposed to harsh conditions, the strain gauge mounted to the bar can be affixed some distance away. This allows protective housings to be utilized which protect the strain gauge but do not interfere with the measurement acquisition. The use of an array of pressure bars allows the pressure-time histories at discrete known points to be measured. This article also describes the interpolation routine used to derive pressure-time histories at un-instrumented locations on the plane of interest. Currently the technique has been used to measure loading from high explosives in free air and buried shallowly in various soils. PMID:27404117

  10. BaBar Explores CP Violation

    International Nuclear Information System (INIS)

    The most recent results obtained by the BABAR experiment at the PEP-II asymmetric-energy B Factory at SLAC on CP-violating asymmetries and branching fractions for neutral and charged B decays are presented here. The analysis was performed on a data sample of ∼ 88 million Υ(4S) → B(bar B) decays collected between 1999 and 2002. Using b → c(bar c)s decays, we measure sin2β = 0.741 ± 0.067(stat) ± 0.034(syst). We also present sin2β measurements from, b → s(bar s)s and b → c(bar c)d processes. From neutral B meson decays to two-body final states of charged pions and kaons, we derive for the CP violating parameters, Sππ = 0.02 ± 0.34 ± 0.05 [-0.54, +0.58] and Cππ = -0.30 ± 0.25 ± 0.04 [-0.72, +0.12]. First results for B → π+π-π0 and K±π±π0 final states dominated by the ρ± resonance, are also presented

  11. Bar instability in disk-halo systems

    CERN Document Server

    Sellwood, J A

    2016-01-01

    We show that the exponential growth rate of a bar in a stellar disk is substantially greater when the disk is embedded in a live halo than in a rigid one having the same mass distribution. We also find that the vigor of the instability in disk-halo systems varies with the shape of the halo velocity ellipsoid. Disks in rigid halos that are massive enough to be stable by the usual criteria, quickly form bars in isotropic halos and much greater halo mass is needed to avoid a strong bar; thus stability criteria derived for disks in rigid halos do not apply when the halo is responsive. The study presented here is of an idealized family of models with near uniform central rotation and that lack an extended halo; we present more realistic models with extended halos in a companion paper. The puzzle presented by the absence of strong bars in some galaxies having gently rising inner rotation curves is compounded by the results presented here.

  12. Shooters:Mini Marvels of the Bar

    OpenAIRE

    Murphy, James Peter

    2010-01-01

    No cocktail bar or mixer repertoire is complete unless it includes a short selection of shooters. Unfortunately in the past these miniature cocktails had a bad image due to poorly conceived promotions where the emphasis was too heavily weighted towards volume rather than delivering a unique taste experience for customers.

  13. Possible strange hidden-charm pentaquarks from $\\Sigma_c^{(*)}\\bar{D}_s^*$ and $\\Xi^{(',*)}_c\\bar{D}^*$ interactions

    CERN Document Server

    Chen, Rui; Liu, Xiang

    2016-01-01

    In a one-boson-exchange model with one-pion and one-eta exchanges, we investigate possible strange hidden-charm pentaquarks produced from the $\\Lambda_c\\bar{D}_s^*$, $\\Sigma_c\\bar{D}_s^*$, $\\Sigma_c^*\\bar{D}_s^*$, $\\Xi_c\\bar{D}^*$, $\\Xi_c'\\bar{D}^*$, and $\\Xi_c^*\\bar{D}^*$ interactions with the S-D wave mixing. The Lagrangians with chiral symmetry, heavy quark symmetry, and/or hidden local symmetry are adopted to describe the interactions. With such Lagrangians, it is found that the $\\Lambda_c\\bar{D}_s^*$ and $\\Xi_c\\bar{D}^*$ interactions are forbidden. For the $\\Sigma_c\\bar{D}_s^*$ and $\\Sigma_c^*\\bar{D}_s^*$ systems where the one-pion exchange is forbidden and only one-eta exchange survives, there exist three molecular candidates at cutoffs about 3 GeV, i.e., a $\\Sigma_c\\bar{D}_s^*$ state with quantum number $I(J^P)=1(\\frac{3}{2}^-)$ and $\\Sigma_c^*\\bar{D}_s^*$ states with $1(\\frac{1}{2}^-)$ and $1(\\frac{3}{2}^-)$. For the $\\Xi_c'\\bar{D}^*$ and $\\Xi_c^*\\bar{D}^*$ systems where the one-pion exchange is allow...

  14. Regulation of lipid metabolism

    Institute of Scientific and Technical Information of China (English)

    Peng LI

    2011-01-01

    @@ Lipids including cholesterol, phospholipids, fatty acids and triacylglycerols are important cellular constituents involved in membrane structure, energy homeostasis and many biological processes such as signal transduction, organelle development and cell differentiation.Recently, the area of lipid metabolism has drawn a great deal of attention due to its emerging role in the development of metabolic disorders such as obesity, diabetes, atherosclerosis and liver steatosis.We decided to organize a special issue of Frontiers in Biology focusing on our current understanding of lipid metabolism.

  15. Star formation properties in barred galaxies. III. Statistical study of bar-driven secular evolution using a sample of nearby barred spirals

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Zhi-Min; Wu, Hong [Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 (China); Cao, Chen, E-mail: zmzhou@bao.ac.cn, E-mail: hwu@bao.ac.cn, E-mail: caochen@sdu.edu.cn [School of Space Science and Physics, Shandong University at Weihai, Weihai, Shandong 264209 (China)

    2015-01-01

    Stellar bars are important internal drivers of secular evolution in disk galaxies. Using a sample of nearby spiral galaxies with weak and strong bars, we explore the relationships between the star formation feature and stellar bars in galaxies. We find that galaxies with weak bars tend coincide with low concentrical star formation activity, while those with strong bars show a large scatter in the distribution of star formation activity. We find enhanced star formation activity in bulges toward stronger bars, although not predominantly, consistent with previous studies. Our results suggest that different stages of the secular process and many other factors may contribute to the complexity of the secular evolution. In addition, barred galaxies with intense star formation in bars tend to have active star formation in their bulges and disks, and bulges have higher star formation densities than bars and disks, indicating the evolutionary effects of bars. We then derived a possible criterion to quantify the different stages of the bar-driven physical process, while future work is needed because of the uncertainties.

  16. Comparison of the lipid properties of healthy and pansteatitis-affected African sharptooth catfish, Clarias gariepinus (Burchell), and the role of diet in pansteatitis outbreaks in the Olifants River in the Kruger National Park, South Africa.

    Science.gov (United States)

    Huchzermeyer, K D A; Osthoff, G; Hugo, A; Govender, D

    2013-11-01

    Pansteatitis has been identified in wild populations of sharptooth catfish, Clarias gariepinus (Burchell), and Nile crocodiles, Crocodylus niloticus Laurenti, inhabiting the same waters in the Olifants River Gorge in the Kruger National Park, South Africa. Mesenteric and pectoral fat tissue was investigated microscopically and by fatty acid analysis in healthy and pansteatitis-affected catfish from both captive and wild populations. Variation in fatty acid composition between pectoral and mesenteric fat was noted. Composition of mesenteric fat differed between fish from various localities as a result of differences in diet. Pansteatitis in the captive population, resulting from ingestion of high amounts of dietary oxidized fat, reflected higher levels of unsaturated fatty acids within the mesenteric fat. Mesenteric fat of pansteatitis-affected wild catfish was characterized by an increase in moisture content, a decrease in fat content and a decrease in stearic and linoleic acids. The n-3 to n-6 fatty acid ratio of mesenteric fat was higher in pansteatitis-affected wild catfish than in healthy catfish from the same locality, reflecting higher polyunsaturated fat intake by pansteatitis-affected fish. The possible role of alien, invasive, phytoplankton-feeding silver carp, Hypophthalmichthys molitrix (Valenciennes), in the aetiology of pansteatitis in both catfish and crocodiles in the Olifants Gorge is discussed. PMID:23634747

  17. Lipid rafts and Alzheimer’s disease: protein-lipid interactions and perturbation of signalling

    Directory of Open Access Journals (Sweden)

    NataliaNNalivaeva

    2012-06-01

    Full Text Available Lipid rafts are membrane domains, more ordered than the bulk membrane and enriched in cholesterol and sphingolipids. They represent a platform for protein-lipid and protein-protein interactions and for cellular signalling events. In addition to their normal functions, including membrane trafficking, ligand binding (including viruses, axonal development and maintenance of synaptic integrity, rafts have also been implicated in the pathogenesis of several neurodegenerative diseases including Alzheimer’s disease (AD. Lipid rafts promote interaction of the amyloid precursor protein (APP with the secretase (BACE-1 responsible for generation of the amyloid β peptide, Aβ. Rafts also regulate cholinergic signalling as well as acetylcholinesterase and Aβ interaction. In addition, such major lipid raft components as cholesterol and GM1 ganglioside have been directly implicated in pathogenesis of the disease. Perturbation of lipid raft integrity can also affect various signalling pathways leading to cellular death and AD. In this review, we discuss modulation of APP cleavage by lipid rafts and their components, while also looking at more recent findings on the role of lipid rafts in signalling events.

  18. Structural Behavior of Concrete Beams Reinforced with Basalt Fiber Reinforced Polymer (BFRP) Bars

    Science.gov (United States)

    Ovitigala, Thilan

    The main challenge for civil engineers is to provide sustainable, environmentally friendly and financially feasible structures to the society. Finding new materials such as fiber reinforced polymer (FRP) material that can fulfill the above requirements is a must. FRP material was expensive and it was limited to niche markets such as space shuttles and air industry in the 1960s. Over the time, it became cheaper and spread to other industries such as sporting goods in the 1980-1990, and then towards the infrastructure industry. Design and construction guidelines are available for carbon fiber reinforced polymer (CFRP), aramid fiber reinforced polymer (AFRP) and glass fiber reinforced polymer (GFRP) and they are currently used in structural applications. Since FRP is linear elastic brittle material, design guidelines for the steel reinforcement are not valid for FRP materials. Corrosion of steel reinforcement affects the durability of the concrete structures. FRP reinforcement is identified as an alternative to steel reinforcement in corrosive environments. Although basalt fiber reinforced polymer (BFRP) has many advantages over other FRP materials, but limited studies have been done. These studies didn't include larger BFRP bar diameters that are mostly used in practice. Therefore, larger beam sizes with larger BFRP reinforcement bar diameters are needed to investigate the flexural and shear behavior of BFRP reinforced concrete beams. Also, shear behavior of BFRP reinforced concrete beams was not yet studied. Experimental testing of mechanical properties and bond strength of BFRP bars and flexural and shear behavior of BFRP reinforced concrete beams are needed to include BFRP reinforcement bars in the design codes. This study mainly focuses on the use of BFRP bars as internal reinforcement. The test results of the mechanical properties of BFRP reinforcement bars, the bond strength of BFRP reinforcement bars, and the flexural and shear behavior of concrete beams

  19. Marine lipids and the bioavailability of omega-3 fatty acids

    DEFF Research Database (Denmark)

    Mu, Huiling; Müllertz, Anette

    2015-01-01

    Marine lipids are enriched with omega-3 fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Omega-3 fatty acids are important membrane lipids and have many recognized health benefits, the bioavailability of these fatty acids can therefore be important for achieving...... bioavailability of omega-3 fatty acids has been reported to be affected by several factors; among the important factors were the digestion and absorption processes of omega-3 containing lipids in the gastrointestinal tract. Both lipid structures and food structures can affect the bioavailability of omega-3 fatty....... In vitro studies provided a mechanistic understanding on the varied bioavailability caused by different lipid structures, the lower relative bioavailability of omega-3 fatty acids from FAEE formulation was closely related to the slower digestion rate of FAEE. Microencapsulated fish oil has often been...

  20. PASTING PROPERTY DIFFERENCES OF COMMERCIAL AND ISOLATED RICE STARCH WITH ADDED LIPIDS AND B-CYCLODEXTRIN

    Science.gov (United States)

    Lipids are known to generally affect starch properties but the effects of lipid structure and B-cyclodextrin (B-CD) on different starches has not been investigated. This study compared the effects of lipids and B-CD on pasting properties of isolated rice starch with commercial rice starch. Four wa...

  1. The Morphology of Collisionless Galactic Rings Exterior to Evolving Bars

    CERN Document Server

    Bagley, Micaela; Quillen, Alice C

    2008-01-01

    The morphology of the outer rings of early-type spiral galaxies is compared to integrations of massless collisionless particles initially in nearly circular orbits. Particles are perturbed by a quadrupolar gravitational potential corresponding to a growing and secularly evolving bar. We find that outer rings with R1R2 morphology and pseudorings are exhibited by the simulations even though they lack gaseous dissipation. Simulations with stronger bars form pseudorings earlier and more quickly than those with weaker bars. We find that the R1 ring, perpendicular to the bar, is fragile and dissolves after a few bar rotation periods if the bar pattern speed increases by more than ~ 8%, bar strength increases (by >~ 140%) after bar growth, or the bar is too strong (Q_T>0.3). If the bar slows down after formation, pseudoring morphology persists and the R2 ring perpendicular to the bar is populated due to resonance capture. The R2 ring remains misaligned with the bar and increases in ellipticity as the bar slows down....

  2. Short-term overt hypothyroidism affect on lipids after thyroxine-withdrawal in patients with differentiated thyroid carcinoma%骨巨细胞瘤软组织内复发两例报道及文献复习

    Institute of Scientific and Technical Information of China (English)

    Hongyu Wu; Shuyao Zuo; Chao Ma; Bin Liu; Fengyu Wu; Simin Liu; Qin Zhang; Xifu Lan

    2009-01-01

    Objective: The aim of the study was to investigate the effects of short-term overt hypothyroidism on lipids after thyroxine-withdrawal in patients with iatrogenically induced hypothyroidism before radioiodine treatment for differentiated thyroid carcinoma (DTC). Methods: Thirty patients with a history of differentiated thyroid carcinoma on thyroid-stimulating hormone (TSH)-suppressive thyroxine replacement therapy were studied. Blood sample were taken before and 4 weeks after withdrawal of thyroxine substitution. Venous blood was drawn after an overnight fast and analyzed for serum free T4 (FT4), free T3 (FT3), thyroid-stimulating hormone (TSH), total cholesterol (TC), triglyceddes (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB). Fifty healthy people matched for age and gender were controls. Their blood samples were taken only once. Results: After thyroxine-withdrawal, the patients presented with increased serum TSH and low serum FT4 and FT3 levels compared with controls. Serum TG, TC, LDL, HDL, APOB and Lp(a) increased after thyroxine withdrawal, reaching statistical significant dif-ferences with previous evaluation. However, when compared to euthyroid controls, only TC, LDL and ApoB were increased when patients were hypothyroidism. No changes were observed in ApoA1 in patients dudng thyroxine withdrawal, or when comparing the values observed in patients to those of euthyroid controls. Conclusion: TG, TC, LDL, HDL, APO8 and Lp(a) were increased during short-term overt hypothyroidism.

  3. Polyene-lipids: a new tool to image lipids

    DEFF Research Database (Denmark)

    Kuerschner, Lars; Ejsing, Christer S.; Ekroos, Kim;

    2005-01-01

    superiority of polyene-lipids to both NBD- and BODIPY-tagged lipids. Cells readily take up various polyene-lipid precursors and generate the expected end products with no apparent disturbance by the tag. Applying two-photon excitation microscopy, we imaged the distribution of polyene-lipids in living......Microscopy of lipids in living cells is currently hampered by a lack of adequate fluorescent tags. The most frequently used tags, NBD and BODIPY, strongly influence the properties of lipids, yielding analogs with quite different characteristics. Here, we introduce polyene-lipids containing five...

  4. Irradiation on cereal bars incorporated with pineapple skin

    International Nuclear Information System (INIS)

    One of the major current concerns to the food industry is the management of residues generated in its production processes. Thus, several studies have been developed, seeking alternative uses for these residues, in order to minimize environmental impacts and add value to products previously discarded. Combining this idea with the increasingly search for healthy and practical products, by consumers, this study aimed the characterization of cereal bars irradiated with doses of 0 kGy, 1 kGy, and 2 kGy, incorporated with dried pineapple skin. The following analyses were carried out: moisture, proteins, lipids, ashes, carbohydrates, energetic value, antioxidant potential, phenolic content, organic acids, and fatty acids profile. The results observed for the centesimal composition did not vary as a function of the radiation doses used, reducing only the levels of antioxidants, phenolic compounds, and organic acids. The product showed potential for becoming an effective way of reusing a food industry residue and the irradiation interfered on the nutritional characteristics of the final product. (author)

  5. CP asymmetry Relations Between $\\bar B^0\\rightarrow \\pi\\pi$ and $\\bar B^0\\rightarrow \\pi K$ Rates

    OpenAIRE

    Deshpande, N. G.; He, Xiao-Gang(INPAC, SKLPPC and Department of Physics, Shanghai Jiao Tong University, Shanghai, China)

    1994-01-01

    We prove that CP violating rate difference $\\Delta (\\bar B^0 \\rightarrow \\pi^+\\pi^-) = \\Gamma (\\bar B^0 \\rightarrow \\pi^+\\pi^-) - \\Gamma ( B^0 \\rightarrow \\pi^-\\pi^+)$ is related to $\\Delta (\\bar B^0 \\rightarrow \\pi^+ K^-) = \\Gamma (\\bar B^0 \\rightarrow \\pi^+K^-) - \\Gamma (B^0 \\rightarrow \\pi^-K^+)$ in the three generation Standard Model. Neglecting small annihilation diagrams, and in the SU(3) symmetry limit, we show $\\Delta (\\bar B^0 \\rightarrow \\pi^+\\pi^-) = - \\Delta (\\bar B^0 \\rightarrow ...

  6. Studies of bb-bar gluon and cc-bar vertices

    International Nuclear Information System (INIS)

    We report on several new studies of bb-barg and cc-barg vertices using 3- and 4-jet hadronic Z0 decays by e+e- collision. The gluon energy spectrum is measured over the full kinematic range, providing an improved test of QCD and limits on anomalous bbg couplings. The parity violation in Z0 → bb-barg decays is consistent with electroweak theory plus QCD. New tests of T- and CP-conservation at the bbg vertex are performed. A measurement of the probability of gluon splitting into cc-bar pairs finds gcc-bar = (2.45 ± 0.29 ± 0.53)%. A new measurement of the rate of gluon splitting into bb-bar pairs yields gbb-bar = (2.84 ± 0.61 (stat.) ± 0.59(yst.)) x 10-3 (Preliminary). (author)

  7. Atomistic study of lipid membranes containing chloroform: looking for a lipid-mediated mechanism of anesthesia.

    Directory of Open Access Journals (Sweden)

    Ramon Reigada

    Full Text Available The molecular mechanism of general anesthesia is still a controversial issue. Direct effect by linking of anesthetics to proteins and indirect action on the lipid membrane properties are the two hypotheses in conflict. Atomistic simulations of different lipid membranes subjected to the effect of small volatile organohalogen compounds are used to explore plausible lipid-mediated mechanisms. Simulations of homogeneous membranes reveal that electrostatic potential and lateral pressure transversal profiles are affected differently by chloroform (anesthetic and carbon tetrachloride (non-anesthetic. Simulations of structured membranes that combine ordered and disordered regions show that chloroform molecules accumulate preferentially in highly disordered lipid domains, suggesting that the combination of both lateral and transversal partitioning of chloroform in the cell membrane could be responsible of its anesthetic action.

  8. Simulations of Barred Galaxies in Triaxial Dark Matter Haloes: The Effects of Gas

    CERN Document Server

    Machado, Rubens E G; Rodionov, S A

    2012-01-01

    The baryonic discs of galaxies are believed to alter the shapes of the dark matter haloes in which they reside. We perform a set of hydrodynamical N-body simulations of disc galaxies with triaxial dark matter haloes, using elliptical discs with a gaseous component as initial conditions. We explore models of different halo triaxiality and also of different initial gas fractions, which allows us to evaluate how each affects the formations of the bar. Due to star formation, models of all halo shapes and of all initial gas fractions reach approximately the same gas content at the end of the simulation. Nevertheless, we find that the presence of gas in the early phases has important effects on the subsequent evolution. Bars are generally weaker for larger initial gas content and for larger halo triaxiality. The presence of gas, however, is a more efficient factor in inhibiting the formation of a strong bar than halo triaxiality is.

  9. Relationship among forging technology, structure and properties of TC21 alloy bars

    Institute of Scientific and Technical Information of China (English)

    QU Heng-lei; LI Hui; ZHANG Ying-nan; GUO Hong-chao; ZHOU Yi-gang; ZHOU Lian; ZHAO Yong-qing; ZENG Wei-dong; FENG Liang; YANG Yan-qing; CHEN Jun; YU Han-qing

    2005-01-01

    As candidate of structural material for advanced domestic aircraft, a new high strength and toughness titanium alloy TC21 was studied focusing on forging technology and microstructure as well as mechanical properties.Two specification ingots and bars were adopted. The results show that basket-weave microstructure is obtained in bars produced by beta finish-forging method; while duplex or tri-modal microstructure appears in bars manufactured by near-beta forging technology. Essential reason affecting structure characteristics is the difference in forging tem perature and deformation amount. Variation in lamellar spacing results in fluctuation of properties corresponding to basket-weave microstructure; however, ideal matching of properties can be reached by near-beta forging.

  10. Modelling anisotropic water transport in polymer composite reinforced with aligned triangular bars

    Indian Academy of Sciences (India)

    Bryan Pajarito; Masatoshi Kubouchi; Saiko Aoki

    2014-02-01

    This work reports anisotropic water transport in a polymer composite consisting of an epoxy matrix reinforced with aligned triangular bars made of vinyl ester. By gravimetric experiments, water diffusion in resin and polymer composites were characterized. Parameters for Fickian diffusion and polymer relaxation models were determined by least-square curve fitting to the experimental data. Diffusion parameters of epoxy and vinyl ester resin were used as input during development of finite element (FE) model of polymer composite. Through transient FE diffusion analysis, anisotropic water transport in thickness direction of the polymer composite was numerically predicted and validated against experimental results. The case of using impermeable triangular bars was also numerically simulated. The diffusivity of reinforced aligned triangular bars was confirmed to affect anisotropic water transport in the composite. The results of this work suggest possible use of polymer composite for barrier and fluid removal applications.

  11. Predictions for NDK, K-bar DN and ND D-bar molecules

    International Nuclear Information System (INIS)

    In this work baryon systems made of three hadrons which contain one nucleon and one D meson, and in addition another meson, D-bar , K or K-bar , are investigated using the Fixed Center Approximation to the Faddeev equations. In this work we use Λc(2595), X(3700) and D*s0(2317) bound states as a cluster and a third particle scattering form that clusters. In all cases we find bound states and quasibound states.

  12. DYNAMICAL CALCULATIONS OF (K)over-bar AND MULTI-(K)over-bar NUCLEI

    Czech Academy of Sciences Publication Activity Database

    Gazda, D.; Mareš, Jiří; Friedman, E.; Gal, A.

    2009-01-01

    Roč. 24, 2-3 (2009), s. 438-441. ISSN 0217-751X. [Conference MESON 2008. Jagiellonian Univ, Cracow, 06.06.2008-10.06.2008] R&D Projects: GA AV ČR IAA100480617 Institutional research plan: CEZ:AV0Z10480505 Keywords : (K)over-bar-nuclear RMF calculations * (K)over-bar-nuclear bound states * kaon condensation Subject RIV: BE - Theoretical Physics Impact factor: 0.941, year: 2009

  13. Lipids in Marine Ecosystems

    OpenAIRE

    Christopher C Parrish

    2013-01-01

    Lipids provide the densest form of energy in marine ecosystems. They are also a solvent and absorption carrier for organic contaminants and thus can be drivers of pollutant bioaccumulation. Among the lipids, certain essential fatty acids and sterols are considered to be important determinants of ecosystem health and stability. Fatty acids and sterols are also susceptible to oxidative damage leading to cytotoxicity and a decrease in membrane fluidity. The physical characteristics of biological...

  14. LIPID PEROXIDATION IN PREECLAMPSIA

    OpenAIRE

    T. Sharmila Krishna; D. Raja Rajeswari; E. Venkat Rao; Sk. Deepthi; Naidu, J.N.

    2015-01-01

    Hypertension in pregnancy is a leading cause of both maternal and fetal mortality and morbidity. Preeclampsia is characterised by hypertension and proteinuria. Lipid peroxidation is an important factor in the pathophysiology of Preeclampsia. The present study was undertaken to determine Serum Malondialdehyde (MDA) levels , a product of lipid peroxidation , in clinically diagnosed Preeclamptic women(n=30) and the values were compared with that of Normotensive pregnant women (n=30) aged between...

  15. Evaluation of FRP Bars Performance under High Temperature

    Science.gov (United States)

    Kashwani, Ghanim A.; Al-Tamimi, Adil K.

    Fiber reinforced polymer bars are increasingly used in the construction industry. Strength, durability and stability are the main criteria for selection and design of FRP. However in case of exposure to high temperature, the change in the material properties affects the overall structure performance. Extensive materials evaluation and numerical modeling are needed to determine any repair/demolish recommendations. FRP bar is one of the main choices for high corrosion resistance in sever environmental conditions. However, FRP materials lose their strength and stiffness at early stage due to high temperature. Many investigations have been carried out on the performance of FRP bond strength exposed to high temperature. In this paper, two different groups of Glass fiber reinforced polymer (GFRP) specimens were tested to determine the effect of the high temperature. Tensile test was applied on all specimens with three different speed rates where the critical temperature for this experiment was 350 °C. From the results and the graphs, the effects of the temperature were explained and analyzed. It showed a reduction of 32% in the tensile strength due to high temperature exposure and an increase in its ductility.

  16. A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress

    DEFF Research Database (Denmark)

    Surma, Michal A; Klose, Christian; Peng, Debby;

    2013-01-01

    ) desaturase Ole1p. Loss of Ubx2p affects the transcriptional control of OLE1, resulting in impaired FA desaturation and a severe shift toward more saturated membrane lipids. Both the induction of the unfolded protein response and aberrant nuclear membrane morphologies observed in cells lacking UBX2 are......Biological membranes are complex, and the mechanisms underlying their homeostasis are incompletely understood. Here, we present a quantitative genetic interaction map (E-MAP) focused on various aspects of lipid biology, including lipid metabolism, sorting, and trafficking. This E-MAP contains ∼250...... suppressed by the supplementation of unsaturated FAs. Our results point toward the existence of dedicated bilayer stress responses for membrane homeostasis....

  17. The Potential Power of Bar-HRM Technology in Herbal Medicine Identification

    Science.gov (United States)

    Sun, Wei; Li, Jing-jian; Xiong, Chao; Zhao, Bo; Chen, Shi-lin

    2016-01-01

    The substitution of low-cost or adulterated herbal products for high-priced herbs makes it important to be able to identify and trace herbal plant species and their processed products in the drug supply chain. PCR-based methods play an increasing role in monitoring the safety of herbal medicines by detecting adulteration. Recent studies have shown the potential of DNA barcoding combined with high resolution melting (Bar-HRM) analysis in herbal medicine identification. This method involves precisely monitoring the change in fluorescence caused by the release of an intercalating DNA dye from a DNA duplex as it is denatured by a gradual increase in temperature. Since the melting profile depends on the GC content, length, and strand complementarity of the amplification product, Bar-HRM analysis opens up the possibility of detecting single-base variants or species-specific differences in a short region of DNA. This review summarizes key factors affecting Bar-HRM analysis and describes how Bar-HRM is performed. We then discuss advances in Bar-HRM analysis of medicinal plant ingredients (herbal materia medica) as a contribution toward safe and effective herbal medicines. PMID:27066026

  18. The potential power of Bar-HRM technology in herbal medicine identification

    Directory of Open Access Journals (Sweden)

    Wei eSun

    2016-03-01

    Full Text Available The substitution of low-cost or adulterated herbal products for high-priced herbs makes it important to be able to identify and trace herbal plant species and their processed products in the drug supply chain. PCR-based methods play an increasing role in monitoring the safety of herbal medicines by detecting adulteration. Recent studies have shown the potential of DNA barcoding combined with High Resolution Melting (Bar-HRM analysis in herbal medicine identification. This method involves precisely monitoring the change in fluorescence caused by the release of an intercalating DNA dye from a DNA duplex as it is denatured by a gradual increase in temperature. Since the melting profile depends on the GC content, length, and strand complementarity of the amplification product, Bar-HRM analysis opens up the possibility of detecting single-base variants or species-specific differences in a short region of DNA. This review summarizes key factors affecting Bar-HRM analysis and describes how Bar-HRM is performed. We then discuss advances in Bar-HRM analysis of medicinal plant ingredients (herbal materia medica as a contribution towards safe and effective herbal medicines.

  19. The Potential Power of Bar-HRM Technology in Herbal Medicine Identification.

    Science.gov (United States)

    Sun, Wei; Li, Jing-Jian; Xiong, Chao; Zhao, Bo; Chen, Shi-Lin

    2016-01-01

    The substitution of low-cost or adulterated herbal products for high-priced herbs makes it important to be able to identify and trace herbal plant species and their processed products in the drug supply chain. PCR-based methods play an increasing role in monitoring the safety of herbal medicines by detecting adulteration. Recent studies have shown the potential of DNA barcoding combined with high resolution melting (Bar-HRM) analysis in herbal medicine identification. This method involves precisely monitoring the change in fluorescence caused by the release of an intercalating DNA dye from a DNA duplex as it is denatured by a gradual increase in temperature. Since the melting profile depends on the GC content, length, and strand complementarity of the amplification product, Bar-HRM analysis opens up the possibility of detecting single-base variants or species-specific differences in a short region of DNA. This review summarizes key factors affecting Bar-HRM analysis and describes how Bar-HRM is performed. We then discuss advances in Bar-HRM analysis of medicinal plant ingredients (herbal materia medica) as a contribution toward safe and effective herbal medicines. PMID:27066026

  20. Wave interaction with a partially reflecting vertical wall protected by a submerged porous bar

    Science.gov (United States)

    Zhao, Yang; Liu, Yong; Li, Huajun

    2016-08-01

    This study gives an analytical solution for wave interaction with a partially reflecting vertical wall protected by a submerged porous bar based on linear potential theory. The whole study domain is divided into multiple sub-regions in relation to the structures. The velocity potential in each sub-region is written as a series solution by the separation of variables. A partially reflecting boundary condition is used to describe the partial reflection of a vertical wall. Unknown expansion coefficients in the series solutions are determined by matching velocity potentials among different sub-regions. The analytical solution is verified by an independently developed multi-domain boundary element method (BEM) solution and experimental data. The wave run-up and wave force on the partially reflecting vertical wall are estimated and examined, which can be effectively reduced by the submerged porous bar. The horizontal space between the vertical wall and the submerged porous bar is a key factor, which affects the sheltering function of the porous bar. The wave resonance between the porous bar and the vertical wall may disappear when the vertical wall has a low reflection coefficient. The present analytical solution may be used to determine the optimum parameters of structures at a preliminary engineering design stage.

  1. Bar pattern speeds in CALIFA galaxies: I. Fast bars across the Hubble sequence

    CERN Document Server

    Aguerri, J A L; Falcón-Barroso, J; Amorin, A; Barrera-Ballesteros, J; Fernandes, R Cid; García-Benito, R; García-Lorenzo, B; Delgado, R M González; Husemann, B; Kalinova, V; Lyubenova, M; Marino, R A; Márquez, I; Mast, D; Pérez, E; Sánchez, S F; van de Ven, G; Walcher, C J; Backsmann, N; Cortijo-Ferrero, C; Bland-Hawthorn, J; del Olmo, A; Iglesias-Páramo, J; Pérez, I; Sánchez-Blázquez, P; Wisotzki, L; Ziegler, B

    2015-01-01

    The bar pattern speed ($\\Omega_{\\rm b}$) is defined as the rotational frequency of the bar, and it determines the bar dynamics. Several methods have been proposed for measuring $\\Omega_{\\rm b}$. The non-parametric method proposed by Tremaine \\& Weinberg (1984; TW) and based on stellar kinematics is the most accurate. This method has been applied so far to 17 galaxies, most of them SB0 and SBa types. We have applied the TW method to a new sample of 15 strong and bright barred galaxies, spanning a wide range of morphological types from SB0 to SBbc. Combining our analysis with previous studies, we investigate 32 barred galaxies with their pattern speed measured by the TW method. The resulting total sample of barred galaxies allows us to study the dependence of $\\Omega_{\\rm b}$ on galaxy properties, such as the Hubble type. We measured $\\Omega_{\\rm b}$ using the TW method on the stellar velocity maps provided by the integral-field spectroscopy data from the CALIFA survey. Integral-field data solve the problem...

  2. Rare kaon decays: $K^{+} → ^{+} \\bar{}$ and future

    Indian Academy of Sciences (India)

    Bipul Bhuyan

    2004-03-01

    The experimental progress in the search for $K^{+} → ^{+} \\bar{}$ will be presented in this paper. Also the physics potential of the proposed BNL experiment to search for $K_{L}^{0} → ^{0} \\bar{}$ (KOPIO) will be discussed.

  3. AGN spiral galaxies in groups: effects of bars

    OpenAIRE

    Alonso, Sol; Coldwell, Georgina; Lambas, Diego García

    2014-01-01

    We explore properties of barred active spiral galaxies in groups selected from the SDSS-DR7, with the aim of assessing the effects of bars on AGN and the role of the high density environment. We identified barred active galaxies that reside in groups from SDSS-DR7 group catalog. To provide a suitable quantification of the effects of bars, a reliable control sample of unbarred active galaxies in high density environments with similar redshift, magnitude, morphology, and bulge size distribution...

  4. Initial magnetic field distribution around high rectangular bus bars

    OpenAIRE

    Cividjian Grigore A.

    2014-01-01

    The one-dimensional transient electromagnetic field in and around a system of two nonmagnetic homogenous rectangular high thin bars can be analytically evaluated if the ratio of average initial magnetic field on the two sides of thin bar, or of the ratio of initial magnetic fields in middle of the bar height is known. In this paper, using appropriate conformal mappings, an exact analytical solution for these ratios are proposed in the case of very thin bars...

  5. A simple and rapid method to characterize lipid fate in skeletal muscle

    OpenAIRE

    Massart, Julie; Zierath, Juleen R.; Chibalin, Alexander V.

    2014-01-01

    Background Elevated fatty acids contribute to the development of type 2 diabetes and affect skeletal muscle insulin sensitivity. Since elevated intramuscular lipids and insulin resistance is strongly correlated, aberrant lipid storage or lipid intermediates may be involved in diabetes pathogenesis. The aim of this study was to develop a method to determine the dynamic metabolic fate of lipids in primary human skeletal muscle cells and in intact mouse skeletal muscle. We report a simple and fa...

  6. Applications of bar code technology at nuclear power plants

    International Nuclear Information System (INIS)

    Bar code is an emerging technology that can eliminate handwritten and keyboard data-entry errors. With application-specific software, bar code technology can provide inventory control, reducing staff time and paperwork. This paper summarizes bar code technology, describes hardware commercially available, and reviews application software systems for use in nuclear power plants

  7. Prediction of Vibration Transmission within Periodic Bar Structures

    DEFF Research Database (Denmark)

    Domadiya, Parthkumar Gandalal; Andersen, Lars Vabbersgaard; Sorokin, Sergey

    2012-01-01

    The present analysis focuses on vibration transmission within semi-infinite bar structure. The bar is consisting of two different materials in a periodic manner. A periodic bar model is generated using two various methods: The Finite Element method (FEM) and a Floquet theory approach. A parameter...

  8. 21 CFR 886.5800 - Ophthalmic bar reader.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ophthalmic bar reader. 886.5800 Section 886.5800...) MEDICAL DEVICES OPHTHALMIC DEVICES Therapeutic Devices § 886.5800 Ophthalmic bar reader. (a) Identification. An ophthalmic bar reader is a device that consists of a magnifying lens intended for use by...

  9. $\\chi^{\\vphantom\\dagger}_{c0}(3915)$ As the Lightest $c\\bar c s \\bar s$ State

    CERN Document Server

    Lebed, Richard F

    2016-01-01

    The state $\\chi^{\\vphantom\\dagger}_{c0}(3915)$ has recently been demoted by the Particle Data Group from its previous status as the conventional $c\\bar c$ $2 {}^3P_0$ state, largely due to the absence of expected $D\\bar D$ decays. We propose that $\\chi^{\\vphantom\\dagger}_{c0}(3915)$ is actually the lightest $c\\bar c s \\bar s$ state, and calculate the spectrum of such states using the diquark model, identifying many of the observed charmoniumlike states that lack open-charm decay modes as $c\\bar c s \\bar s$. Among other results, we argue that $Y(4140)$ is a $J^{PC} = 1^{++}$ $c\\bar c s \\bar s$ state that has been not been seen in two-photon fusion largely as a consequence of the Landau-Yang theorem.

  10. Influence of a hyperlipidic diet on the composition of the non-membrane lipid pool of red blood cells of male and female rats.

    OpenAIRE

    Remesar, Xavier; Antelo, Arantxa; Llivina, Clàudia; Albà, Emma; Berdié, Lourdes; Agnelli, Silvia; Arriarán, Sofía; Fernández-López, José Antonio; Alemany, Marià

    2015-01-01

    Background and objectives. Red blood cells (RBC) are continuously exposed to oxidative agents, affecting their membrane lipid function. However, the amount of lipid in RBCs is higher than the lipids of the cell membrane, and includes triacylglycerols, which are no membrane components. We assumed that the extra lipids originated from lipoproteins attached to the cell surface, and we intended to analyse whether the size and composition of this lipid pool were affected by sex or diet. Experiment...

  11. A train for the bus(bars)

    CERN Multimedia

    CERN Bulletin

    2013-01-01

    On 8 April, the first SMACC (Superconducting Magnets and Circuits Consolidation) teams began work in the LHC tunnel. They are responsible for opening the interconnects between the magnets, laying the groundwork for the series of operations that will be performed by the team riding the ‘consolidation train’.   A technician installs the machine tool that allows them to prepare the surface of the section of the bar where the shunt will be fixed. The LHC’s 1,670 dipoles and quadrupoles are powered by power converters and connected by copper 'busbars’. The superconducting cables run through these bars, carrying a current of up to 11,850 amps. Six superconducting cables meet at each interconnect, where they are held together by a soldered (see box) electrical connection sandwiched between two pieces of copper, forming the splice between the busbars of the neighbouring magnets. The integrity of the electrical circuit is depen...

  12. Bar-code automated waste tracking system

    International Nuclear Information System (INIS)

    The Bar-Code Automated Waste Tracking System was designed to be a site-Specific program with a general purpose application for transportability to other facilities. The system is user-friendly, totally automated, and incorporates the use of a drive-up window that is close to the areas dealing in container preparation, delivery, pickup, and disposal. The system features ''stop-and-go'' operation rather than a long, tedious, error-prone manual entry. The system is designed for automation but allows operators to concentrate on proper handling of waste while maintaining manual entry of data as a backup. A large wall plaque filled with bar-code labels is used to input specific details about any movement of waste

  13. The Disability Dilemma: A Skeptical Bench & Bar

    Directory of Open Access Journals (Sweden)

    Wendy F. Hensel

    2008-04-01

    Full Text Available The legal profession is no stranger to the bias and prejudice present in American society. Members of the bar have been shown to engage in both conscious and subconscious sexism and racism, posing challenges to the profession as the profile of those practicing law has changed over the last several decades to admit increasing numbers of women and minorities.1 Nevertheless, it is notable that few, if any, members of the bar today would question openly whether women or people of color have the ability to be successful, productive members of the profession. Instead, the conventional wisdom is that the greatest obstacles to their success will come in the form of external barriers and institutional policies based on preconceived norms that do not acknowledge the divergent challenges faced by these group members.

  14. A Distinct Structure Inside the Galactic Bar

    CERN Document Server

    Nishiyama, S; Baba, D; Haba, Y; Kadowaki, R; Kato, D; Kurita, M; Nagashima, C; Nagayama, T; Murai, Y; Nakajima, Y; Tamura, M; Nakaya, H; Sugitani, K; Naoi, T; Matsunaga, N; Tanabé, T; Kusakabe, N; Sato, S; Nishiyama, Shogo; Nagata, Tetsuya; Baba, Daisuke; Haba, Yasuaki; Kadowaki, Ryota; Kato, Daisuke; Kurita, Mikio; Nagashima, Chie; Nagayama, Takahiro; Murai, Yuka; Nakajima, Yasushi; Tamura, Motohide; Nakaya, Hidehiko; Sugitani, Koji; Naoi, Takahiro; Matsunaga, Noriyuki; Tanabe, Toshihiko; Kusakabe, Nobuhiko; Sato, Shuji

    2005-01-01

    We present the result of a near-infrared (J H Ks) survey along the Galactic plane, -10.5deg < l < +10.5deg and b=+1.0deg, with the IRSF 1.4m telescope and the SIRIUS camera. Ks vs. H-Ks color-magnitude diagrams reveal a well-defined population of red clump (RC) stars whose apparent magnitude peak changes continuously along the Galactic plane, from Ks=13.4 at l=-10deg to Ks=12.2 at l=+10deg after dereddening. This variation can be explained by the bar-like structure found in previous studies, but we find an additional inner structure at |l| < 4deg, where the longitude - apparent magnitude relation is distinct from the outer bar, and the apparent magnitude peak changes by only 0.1 mag over the central 8deg. The exact nature of this inner structure is as yet uncertain.

  15. Bar-code automated waste tracking system

    Energy Technology Data Exchange (ETDEWEB)

    Hull, T.E.

    1994-10-01

    The Bar-Code Automated Waste Tracking System was designed to be a site-Specific program with a general purpose application for transportability to other facilities. The system is user-friendly, totally automated, and incorporates the use of a drive-up window that is close to the areas dealing in container preparation, delivery, pickup, and disposal. The system features ``stop-and-go`` operation rather than a long, tedious, error-prone manual entry. The system is designed for automation but allows operators to concentrate on proper handling of waste while maintaining manual entry of data as a backup. A large wall plaque filled with bar-code labels is used to input specific details about any movement of waste.

  16. Strangeness production in pp-bar collision

    International Nuclear Information System (INIS)

    We study strangeness production reactions in the framework of a Chiral Constituent Quark Model. The model includes the coupling with the SU(3) pseudoscalar meson octet due to the spontaneous chiral symmetry breaking. It also includes QCD perturbative effects through the coupling with the gluon field. In this way the two traditional mechanism of strangeness production, i.e., the kaon exchange and gluon annihilation, are introduce in the same framework. Two meson exchanges are parametrized through the exchange of scalar mesons, namely a sigma and a kappa exchange. The kappa exchange allows a better description of the polarization observables of the pp-bar →ΛΛ-bar production reaction. Other strangeness production reaction in the isospin 1 sector are also studied.

  17. Investigating a Hypothetical Semiconductor Laser Bar with a Damaged Single Emitter Using a Laser Diode Simulation/Emulation Tool

    Directory of Open Access Journals (Sweden)

    C.K. Amuzuvi

    2014-02-01

    Full Text Available This study demonstrates the use of Barlase, a semiconductor laser diode emulation tool, to emulate the by-emitter degradation of high power semiconductor laser diodes.Barlase is software that uses a LabView control interface. In this study, a hypothetical laser diode bar (multiple emitters was used to investigate a damaged single emitter randomly located in the bar and its behavior analyzed within the bar. It should however, be noted that, this scenario is valid for devices at the start of the aging process only. When all other relevant effects that affect the performance of laser diodes bars are allowed to interact over time, high levels of defects can also play important role in the degradation process. The results of this simulation scenario show the successful implementation of Barlase in the by-emitter analysis of laser diodes.

  18. Measuring K+ → π+νν-bar and KL0 → π0νν-bar at BNL

    International Nuclear Information System (INIS)

    K+ →π+νν-bar and KL0 → π0νν-bar are ultra-rare kaon decay channels which offer unique opportunities for measuring Standard Model parameters relating to quark mixing and CP violation as well as searching for new physics. In this paper, the prospects for current and future progress on measuring K+ →π+νν-bar and KL0 → π0νν-bar at the Brookhaven AGS are reported. (author)

  19. Rock Bar BTR -liiketoimintasuunnitelma baariyrityksen perustamiseksi

    OpenAIRE

    Rieppo, Jani

    2015-01-01

    Laurea-ammattikorkeakoulu Tiivistelmä Laurea Leppävaara Hotelli- ja ravintola-alan liikkeenjohdon koulutusohjelma Rieppo, Jani Rock Bar BTR -liiketoimintasuunnitelma baariyrityksen perustamiseksi Vuosi 2015 Sivumäärä 58 Tämän toiminnallisen opinnäytetyön tarkoituksena on liiketoimintasuunnitelman laatiminen uudelle rock-baarille, jonka avaaminen Joensuuhun on suunnitelman laatijan toimesta mahdollista joskus tulevaisuudessa. Tavo...

  20. Hadron Physics in BaBar

    Energy Technology Data Exchange (ETDEWEB)

    Lafferty, G.D.; /Manchester U.

    2005-08-29

    Some recent results in hadron physics from the BaBar experiment are discussed. In particular, the observation of two new charmed states, the D*{sub sJ}{sup +}(2317) and the D*{sub sJ}{sup +}(2457), is described, and results are presented on the first measurement of the rare decay mode of the B meson, B{sup 0} {pi}{sup 0}{pi}{sup 0}.

  1. The Expansion of Speakeasy Bar and Grill

    OpenAIRE

    Mills, Joel

    2012-01-01

    This strategic analysis makes recommendations on a course of action for Speakeasy Bar and Grill, located in Vancouver, British Columbia, with regards to growth of the brand. The comprehensive analysis determined that Speakeasy currently generates a competitive source of advantage in large part from the high level of direct involvement of its owners as managers, both in terms of cost and customer value advantages. Sustaining this advantage as the company grows with greater demands being placed...

  2. Sohio's L-Bar uranium mill

    International Nuclear Information System (INIS)

    Sohio Petroleum Company's new L-Bar uranium mill near Grants, New Mexico, refines 2722 kilograms of yellowcake daily from 1360 metric tons of ore produced at Sohio's J.J. No. 1 mine and other nearby mines. This paper follows the ore from the mine through the various processing steps - semi-autogenous grinding, acid leaching, countercurrent decantation, solvent extraction, ammonium diuranate precipitation, washing and drying, and tailings disposal. (author)

  3. Dowel Bar Retrofit Mix Design and Specification

    OpenAIRE

    Deshpande, Yogini; Olek, Jan

    2012-01-01

    When dealing with the issue of repair of concrete pavement repair using dowel bar retrofit technique, it is very desirable for the repair material to have high fluidity that can ensure good compaction and facilitate flow to tight spaces, preferably without the use of a vibrator. The focus of this project was on identifying critical properties that control long-term performance of repair concrete, especially rapid-setting materials extended using pea gravel (maximum size aggregate 9.5 mm). ...

  4. Ballymore Inn Restaurant Back Bar Menu

    OpenAIRE

    Ballymore Inn

    2014-01-01

    We opened the doors of the Ballymore Inn in Kildare over 16 years ago guided by our philosophy that the best food comes from carefully selected ingredients infused with an imaginative simplicity. The Ballymore Inn has evolved over those 16 years but this philosophy has remained the same. We grow our own seasonal fruit and vegetables and work with some of the country's best suppliers to ensure the finest dining experience for our customers. Our tastefully decorated restaurant and Back Bar crea...

  5. CP violation in p bar p colliders

    International Nuclear Information System (INIS)

    This paper presents a simple calculation to investigate the possibility of studying CP violation in the B-environment at present p bar p colliders. The authors' conclusion, based on the comparison of CDF, as an example of a standard detector, with a proposed bottom collider detector (BCD), is that observation of CP violation seems to be possible, though very hard, only with specifically designed detectors and with a high integrated luminosity

  6. Bars do drive spiral density waves

    CERN Document Server

    Salo, H; Buta, R; Knapen, J H

    2010-01-01

    Recently, Buta etal. (2009) examined the question "Do Bars Drive Spiral Density Waves?", an idea supported by theoretical studies and also from a preliminary observational analysis Block etal (2004). They estimated maximum bar strengths Q_b, maximum spiral strengths Q_s, and maximum m=2 arm contrasts A_2s for 23 galaxies with deep AAT K_s-band images. These were combined with previously published Q_b and Q_s values for 147 galaxies from the OSUBSGS sample and with the 12 galaxies from Block etal(2004). Weak correlation between Q_b and Q_s was confirmed for the combined sample, whereas the AAT subset alone showed no significant correlations between Q_b and Q_s, nor between Q_b and A_2s. A similar negative result was obtained in Durbala etal. (2009) for 46 galaxies. Based on these studies, the answer to the above question remains uncertain. Here we use a novel approach, and show that although the correlation between the maximum bar and spiral parameters is weak, these parameters do correlate when compared local...

  7. Leptonic B Decays at BaBar

    Energy Technology Data Exchange (ETDEWEB)

    Baracchini, Elisabetta; /Rome U. /INFN, Rome

    2011-11-10

    We will present the most recent results on leptonic B decays B{sup {+-}(0)} {yields} K*{sup {+-}(0)}{nu}{bar {nu}} and B{sup {+-}} {yields} {mu}{sup {+-}}{nu}, based on the data collected by the BaBar detector at PEP-II, an asymmetric e{sup +}e{sup -} collider at the center of mass energy of the {Upsilon}(4S) resonance. Rare B decays have always been a standard probe for New Physics (NP) searches. The very low Standard Model (SM) rate of these decays often make them unaccessible with the present experimental datasets, unless NP effects enhance the rate up to the current experimental sensitivity. Moreover, as NP effects can modify the decay kinematic, particular attention must be paid in order to perform a model independent analysis. A B-Factory provides an unique environment to investigate these processes. The high number of B{bar B} pairs produced by a B-Factory often allows to approach the needed experimental sensitivity. Moreover, the clean environment and the closed kinematic of the initial state enable to obtaining a very pure sample where to look for these decays.

  8. Leptonic B Decays at BaBar

    Energy Technology Data Exchange (ETDEWEB)

    Monorchio, Diego; /INFN, Naples /Naples U.

    2011-09-13

    The authors will present the most recent results on leptonic B decays B{sup {+-}(0)} {yields} K*{sup {+-}(0)} {nu}{bar {nu}} and B{sup {+-}} {yields} {mu}{sup {+-}}{nu}, based on the data collected by the BaBar detector at PEP-II, an asymmetric e{sup +}e{sup -} collider at the center of mass energy of the {Upsilon}(4S) resonance. Rare B decays have always been a standard probe for New Physics (NP) searches. The very low Standard Model (SM) rate of these decays often make them unaccessible with the present experimental datasets, unless NP effects enhance the rate up to the current experimental sensitivity. Moreover, as NP effects can modify the decay kinematic, particular attention must be payed in order to perform a model independent analysis. A B-Factory provides an unique environment where to investigate these processes. The high number of B{bar B} pairs produced by a B-Factory often allows to approach the needed experimental sensitivity. Moreover, the clean environment and the closed kinematic of the initial state enable to obtaining a very pure sample where to look for these decays.

  9. New Spectroscopy at BaBar

    Energy Technology Data Exchange (ETDEWEB)

    Mazzoni, M.A.; /INFN, Rome

    2007-04-18

    The Babar experiment at the SLAC B factory has accumulated a high luminosity that offers the possibility of systematic studies of quarkonium spectroscopy and of investigating rare new phenomena. Recent results in this field are presented. In recent times spectroscopy has become exciting again, after the discovery of new states that are not easily explained by conventional models. States such as the X(3872) and the Y(4260) could be new excited charmonium states, but require precise measurements for positive identification. The BaBar experiment [1] is installed at the asymmetric storage ring PEP-II. 90% of the data accumulated by BaBar are taken at the Y(4S) (10.58 GeV) and 10% just below (10.54 GeV). The BaBar detector includes a 5-layer, double-sided silicon vertex tracker and a 40-layer drift chamber in a 1.5 T solenoidal magnetic field, which detect charged particles and measures their momenta and ionization energy losses. Photons, electrons, and neutral hadrons are detected with a CsI(Tl)-crystal electromagnetic calorimeter. An internally reflecting ring-imaging Cherenkov is also used for particle id. Penetrating muon and neutral hadrons are identified by an array of resistive-plate chambers embedded in the steel of the flux return. The detector allows good track and vertex resolution, good particle id and good photon detection so it is especially suited for spectroscopy studies.

  10. BAR-MOM code and its application

    International Nuclear Information System (INIS)

    BAR-MOM code for calculating the height of the fission barrier Bf , the energy of the ground state is presented; the compound nucleus stability by limit with respect to fission, i.e., the angular momentum (the spin value) Lmax at which the fission barrier disappears, the three principal axis moments of inertia at saddle point for a certain nucleus with atomic number Z, atomic mass number A and angular momentum L in units of ℎ for 19< Z<102, and the model used are introduced briefly. The generalized BAR-MOM code to include the results for Z ≥ 102 by using more recent parameterization of the Thomas Fermi fission barrier is also introduced briefly. We have learned the models used in Code BAR-MOM, and run it successfully and correctly for a certain nucleus with atomic mass number A, atomic number Z, and angular momentum L on PC by Fortran-90. The testing calculation values to check the implementation of the program show that the results of the present work are in good agreement with the original one

  11. INFINITELY VARIABLE TRANSMISSION USING FOUR BAR MECHANISM

    Directory of Open Access Journals (Sweden)

    Dr.N. ARUNKUMAR

    2014-04-01

    Full Text Available Most of the continuously variable transmission systems in automobiles now-a-days are non-positive drives. This means that they cannot be used in heavy vehicles that require very high torque to be transmitted. This new type of infinitely variable transmission is aimed at transmitting high torques by making it a positive drive, thus making continuously variable transmission systems to be suitable for heavy vehicles. Infinitely variable transmission system and continuously variable transmission system are both the same except that there is an extra zero gear ratio in infinitely variable transmission system. This newly developed transmission system is basically a four bar mechanism with variable crank radius which makes it possible to have continuously variable mechanical advantage. The output lever which oscillates in the four bar mechanism is connected to a ratchet mechanism which turns the output shaft intermittently, two four bar mechanisms with a phase difference of 180 degrees is used to avoid the intermittent rotation of the output shaft. A flywheel is used in the output shaft to reduce the fluctuations in both speed and torque.

  12. Lipid signalling in plant responses to abiotic stress.

    Science.gov (United States)

    Hou, Quancan; Ufer, Guido; Bartels, Dorothea

    2016-05-01

    Lipids are one of the major components of biological membranes including the plasma membrane, which is the interface between the cell and the environment. It has become clear that membrane lipids also serve as substrates for the generation of numerous signalling lipids such as phosphatidic acid, phosphoinositides, sphingolipids, lysophospholipids, oxylipins, N-acylethanolamines, free fatty acids and others. The enzymatic production and metabolism of these signalling molecules are tightly regulated and can rapidly be activated upon abiotic stress signals. Abiotic stress like water deficit and temperature stress triggers lipid-dependent signalling cascades, which control the expression of gene clusters and activate plant adaptation processes. Signalling lipids are able to recruit protein targets transiently to the membrane and thus affect conformation and activity of intracellular proteins and metabolites. In plants, knowledge is still scarce of lipid signalling targets and their physiological consequences. This review focuses on the generation of signalling lipids and their involvement in response to abiotic stress. We describe lipid-binding proteins in the context of changing environmental conditions and compare different approaches to determine lipid-protein interactions, crucial for deciphering the signalling cascades. PMID:26510494

  13. Study of the decay $\\bar{B}^{0}\\rightarrow\\Lambda_{c}^{+}\\bar{p}\\pi^{+}\\pi^{-}$ and its intermediate states

    CERN Document Server

    Lees, J P; Tisserand, V; Grauges, E; Palano, A; Eigen, G; Stugu, B; Brown, D N; Kerth, L T; Kolomensky, Yu G; Lynch, G; Koch, H; Schroeder, T; Asgeirsson, D J; Hearty, C; Mattison, T S; McKenna, J A; So, R Y; Khan, A; Blinov, V E; Buzykaev, A R; Druzhinin, V P; Golubev, V B; Kravchenko, E A; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Yushkov, A N; Kirkby, D; Lankford, A J; Mandelkern, M; Atmacan, H; Gary, J W; Long, O; Vitug, G M; Campagnari, C; Hong, T M; Kovalskyi, D; Richman, J D; West, C A; Eisner, A M; Kroseberg, J; Lockman, W S; Martinez, A J; Schumm, B A; Seiden, A; Chao, D S; Cheng, C H; Echenard, B; Flood, K T; Hitlin, D G; Ongmongkolkul, P; Porter, F C; Rakitin, A Y; Andreassen, R; Huard, Z; Meadows, B T; Sokoloff, M D; Sun, L; Bloom, P C; Ford, W T; Gaz, A; Nauenberg, U; Smith, J G; Wagner, S R; Ayad, R; Toki, W H; Spaan, B; Schubert, K R; Schwierz, R; Bernard, D; Verderi, M; Clark, P J; Playfer, S; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Fioravanti, E; Garzia, I; Luppi, E; Piemontese, L; Santoro, V; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Finocchiaro, G; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Contri, R; Guido, E; Vetere, M Lo; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Bhuyan, B; Prasad, V; Morii, M; Adametz, A; Uwer, U; Lacker, H M; Lueck, T; Dauncey, P D; Mallik, U; Chen, C; Cochran, J; Meyer, W T; Prell, S; Rubin, A E; Gritsan, A V; Arnaud, N; Davier, M; Derkach, D; Grosdidier, G; Diberder, F Le; Lutz, A M; Malaescu, B; Roudeau, P; Schune, M H; Stocchi, A; Wormser, G; Lange, D J; Wright, D M; Chavez, C A; Coleman, J P; Fry, J R; Gabathuler, E; Hutchcroft, D E; Payne, D J; Touramanis, C; Bevan, A J; Di Lodovico, F; Sacco, R; Sigamani, M; Cowan, G; Davis, C L; Denig, A G; Fritsch, M; Gradl, W; Griessinger, K; Hafner, A; Prencipe, E; Barlow, R J; Jackson, G; Lafferty, G D; Behn, E; Cenci, R; Hamilton, B; Jawahery, A; Roberts, D A; Dallapiccola, C; Cowan, R; Dujmic, D; Sciolla, G; Cheaib, R; Lindemann, D; Patel, P M; Robertson, S H; Biassoni, P; Neri, N; Palombo, F; Stracka, S; Cremaldi, L; Godang, R; Kroeger, R; Sonnek, P; Summers, D J; Nguyen, X; Simard, M; Taras, P; De Nardo, G; Monorchio, D; Onorato, G; Sciacca, C; Martinelli, M; Raven, G; Jessop, C P; LoSecco, J M; Wang, W F; Honscheid, K; Kass, R; Brau, J; Frey, R; Sinev, N B; Strom, D; Torrence, E; Feltresi, E; Gagliardi, N; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simi, G; Simonetto, F; Stroili, R; Akar, S; Ben-Haim, E; Bomben, M; Bonneaud, G R; Briand, H; Calderini, G; Chauveau, J; Hamon, O; Leruste, Ph; Marchiori, G; Ocariz, J; Sitt, S; Biasini, M; Manoni, E; Pacetti, S; Rossi, A; Angelini, C; Batignani, G; Bettarini, S; Carpinelli, M; Casarosa, G; Cervelli, A; Forti, F; Giorgi, M A; Lusiani, A; Oberhof, B; Perez, A; Rizzo, G; Walsh, J J; Pegna, D Lopes; Olsen, J; Smith, A J S; Anulli, F; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Gioi, L Li; Mazzoni, M A; Piredda, G; Bünger, C; Grünberg, O; Hartmann, T; Leddig, T; Schröder, H; Voß, C; Waldi, R; Adye, T; Olaiya, E O; Wilson, F F; Emery, S; de Monchenault, G Hamel; Vasseur, G; Y\\`, Ch; Aston, D; Bartoldus, R; Benitez, J F; Cartaro, C; Convery, M R; Dorfan, J; Dubois-Felsmann, G P; Dunwoodie, W; Ebert, M; Field, R C; Sevilla, M Franco; Fulsom, B G; Gabareen, A M; Graham, M T; Grenier, P; Hast, C; Innes, W R; Kelsey, M H; Kim, P; Kocian, M L; Leith, D W G S; Lewis, P; Lindquist, B; Luitz, S; Luth, V; Lynch, H L; MacFarlane, D B; Muller, D R; Neal, H; Nelson, S; Perl, M; Pulliam, T; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Snyder, A; Su, D; Sullivan, M K; Va'vra, J; Wagner, A P; Wisniewski, W J; Wittgen, M; Wright, D H; Wulsin, H W; Young, C C; Ziegler, V; Park, W; Purohit, M V; White, R M; Wilson, J R; Randle-Conde, A; Sekula, S J; Bellis, M; Burchat, P R; Miyashita, T S; Puccio, E M T; Alam, M S; Ernst, J A; Gorodeisky, R; Guttman, N; Peimer, D R; Soffer, A; Spanier, S M; Ritchie, J L; Ruland, A M; Schwitters, R F; Wray, B C; Izen, J M; Lou, X C; Bianchi, F; Gamba, D; Zambito, S; Lanceri, L; Vitale, L; Martinez-Vidal, F; Oyanguren, A; Villanueva-Perez, P; Ahmed, H; Albert, J; Banerjee, Sw; Bernlochner, F U; Choi, H H F; King, G J; Kowalewski, R; Lewczuk, M J; Nugent, I M; Roney, J M; Sobie, R J; Tasneem, N; Gershon, T J; Harrison, P F; Latham, T E; Band, H R; Dasu, S; Pan, Y; Prepost, R; Wu, S L

    2013-01-01

    We study the decay $\\bar{B}^{0}\\rightarrow\\Lambda_{c}^{+}\\bar{p}\\pi^{+}\\pi^{-}$, reconstructing the \\Lambda_{c}^{+} baryon in the $p K^{-}\\pi^{+}$ mode, using a data sample of $467\\times 10^{6}$ $B\\bar{B}$ pairs collected with the BaBar detector at the PEP-2 storage rings at SLAC. We measure branching fractions for decays with intermediate $\\Sigma_{c}$ baryons to be ${\\cal B}[\\bar{B}^{0}\\rightarrow\\Sigma_{c}(2455)^{++}\\bar{p}\\pi^{-}]=(21.3 \\pm 1.0 \\pm 1.0 \\pm 5.5) \\times 10^{-5}$, ${\\cal B}[\\bar{B}^{0}\\rightarrow\\Sigma_{c}(2520)^{++}\\bar{p}\\pi^{-}]=(11.5\\pm 1.0 \\pm 0.5 \\pm 3.0)\\times 10^{-5}$, ${\\cal B}[\\bar{B}^{0}\\rightarrow\\Sigma_{c}(2455)^{0}\\bar{p}\\pi^{+}]=(9.1 \\pm 0.7 \\pm 0.4 \\pm 2.4)\\times10^{-5}$, and ${\\cal B}[\\bar{B}^{0}\\rightarrow\\Sigma_{c}(2520)^{0}\\bar{p}\\pi^{+}]= (2.2 \\pm 0.7 \\pm 0.1\\pm 0.6) \\times 10^{-5}$, where the uncertainties are statistical, systematic, and due to the uncertainty on the $\\Lambda_{c}^{+}\\rightarrow\\proton\\Km\\pi^{+}$ branching fraction, respectively. For decays without $\\Sig...

  14. The impact of bars on the radial distribution of supernovae in disc galaxies

    CERN Document Server

    Hakobyan, A A; Barkhudaryan, L V; Mamon, G A; Kunth, D; Petrosian, A R; Adibekyan, V; Aramyan, L S; Turatto, M

    2016-01-01

    We present an analysis of the impact of bars on the radial distributions of the different types of supernovae (SNe) in the stellar discs of host galaxies with various morphologies. We find that in Sa-Sbc galaxies, the radial distribution of core-collapse (CC) SNe in barred hosts is inconsistent with that in unbarred ones, while the distributions of SNe Ia are not significantly different. At the same time, the radial distributions of both types of SNe in Sc-Sm galaxies are not affected by bars. We propose that the additional mechanism shaping the distributions of Type Ia and CC SNe can be explained within the framework of substantial suppression of massive star formation in the radial range swept by strong bars, particularly in early-type spirals. The radial distribution of CC SNe in unbarred Sa-Sbc galaxies is more centrally peaked and inconsistent with that in unbarred Sc-Sm hosts, while the distribution of SNe Ia in unbarred galaxies is not affected by host morphology. These results can be explained by the ...

  15. The impact of bars on the radial distribution of supernovae in disc galaxies

    Science.gov (United States)

    Hakobyan, A. A.; Karapetyan, A. G.; Barkhudaryan, L. V.; Mamon, G. A.; Kunth, D.; Petrosian, A. R.; Adibekyan, V.; Aramyan, L. S.; Turatto, M.

    2016-07-01

    We present an analysis of the impact of bars on the radial distributions of the different types of supernovae (SNe) in the stellar discs of host galaxies with various morphologies. We find that in Sa-Sbc galaxies, the radial distribution of core-collapse (CC) SNe in barred hosts is inconsistent with that in unbarred ones, while the distributions of SNe Ia are not significantly different. At the same time, the radial distributions of both types of SNe in Sc-Sm galaxies are not affected by bars. We propose that the additional mechanism shaping the distributions of Type Ia and CC SNe can be explained within the framework of substantial suppression of massive star formation in the radial range swept by strong bars, particularly in early-type spirals. The radial distribution of CC SNe in unbarred Sa-Sbc galaxies is more centrally peaked and inconsistent with that in unbarred Sc-Sm hosts, while the distribution of SNe Ia in unbarred galaxies is not affected by host morphology. These results can be explained by the distinct distributions of massive stars in the discs of early-and late-type spirals.

  16. Lipid Peroxidation and Lipid Metabolism in Postmenopausal Women

    OpenAIRE

    , Banu ÖNVURAL

    1998-01-01

    The aims of this study were to determine the degree of lipid peroxidation in the sera of postmenopausal women and compare this with the lipid peroxidation of a premenopausal group, and to see if there was any correlation between lipid parameters and lipid peroxidation within the groups. We assayed the lipid profiles and malondialdehyde (MDA), a marker for lipid peroxidation, in a postmenopausal group (n=57, mean age=49.4±6.6), an age-matched male group (n=21, mean age=48.5±6.7) an...

  17. Antihydrogen Production in $ \\bar{p} $ Z - interaction

    CERN Multimedia

    2002-01-01

    % PS210 \\\\ \\\\ The production of the antihydrogen atom $ \\bar {H}^0 \\equiv \\bar{p}e $ as the simplest atomic bound state of antimatter has been studied. Nine $ \\bar {H}^0 $ have been observed.\\\\ \\\\ The production of $ \\bar {H}^0 $ is predominantly mediated by the two-photon mechanism in the antiproton-nucleus interaction. In principle $ \\bar {H}^0 $ is well suited for investigations of fundamental CPT violation studies under different forces, however, in the present experiment we concentrated on the production of this antimatter object, since so far it never had been observed.

  18. Initial magnetic field distribution around high rectangular bus bars

    Directory of Open Access Journals (Sweden)

    Cividjian Grigore A.

    2014-01-01

    Full Text Available The one-dimensional transient electromagnetic field in and around a system of two nonmagnetic homogenous rectangular high thin bars can be analytically evaluated if the ratio of average initial magnetic field on the two sides of thin bar, or of the ratio of initial magnetic fields in middle of the bar height is known. In this paper, using appropriate conformal mappings, an exact analytical solution for these ratios are proposed in the case of very thin bars. Obtained values are compared with FEM results for relatively thick bars.

  19. The influence of the environment on bar formation

    CERN Document Server

    Mendez-Abreu, J; Zarattini, S; Sanchez-Janssen, R; Corsini, E M

    2009-01-01

    Galaxy mergers and interactions are mechanisms which could drive the formation of bars. Therefore, we could expect that the fraction of barred galaxies increases with the local density. Here we show the first results of an extensive search for barred galaxies in different environments. We conclude that the bar fraction on bright (L>L*) field, Virgo, and Coma cluster galaxies is compatible. These results point towards an scenario where the formation and/or evolution of bars depend mostly on internal galaxy processes rather than external ones.

  20. On the spectrum of $\\bar{X}$-bounded minimal submanifolds

    OpenAIRE

    Salavessa, Isabel M. C.

    2009-01-01

    We prove, under a certain boundedness condition at infinity on the $(\\bar{X}^{\\top}, \\bar{X}^{\\bot})$-component of the second fundamental form, the vanishing of the essential spectrum of a complete minimal $\\bar{X}$-bounded and $\\bar{X}$-properly immersed submanifold on a Riemannian manifold endowed with a strongly convex vector field $\\bar{X}$. The same conclusion also holds for any complete minimal $h$-bounded and $h$-properly immersed submanifold that lies in a open set of a Riemannian man...

  1. [Lipid synthesis by an acidic acid tolerant Rhodotorula glutinis].

    Science.gov (United States)

    Lin, Zhangnan; Liu, Hongjuan; Zhang, Jian'an; Wang, Gehua

    2016-03-01

    Acetic acid, as a main by-product generated in the pretreatment process of lignocellulose hydrolysis, significantly affects cell growth and lipid synthesis of oleaginous microorganisms. Therefore, we studied the tolerance of Rhodotorula glutinis to acetic acid and its lipid synthesis from substrate containing acetic acid. In the mixed sugar medium containing 6 g/L glucose and 44 g/L xylose, and supplemented with acetic acid, the cell growth was not:inhibited when the acetic acid concentration was below 10 g/L. Compared with the control, the biomass, lipid concentration and lipid content of R. glutinis increased 21.5%, 171% and 122% respectively when acetic acid concentration was 10 g/L. Furthermore, R. glutinis could accumulate lipid with acetate as the sole carbon source. Lipid concentration and lipid yield reached 3.20 g/L and 13% respectively with the initial acetic acid concentration of 25 g/L. The lipid composition was analyzed by gas chromatograph. The main composition of lipid produced with acetic acid was palmitic acid, stearic acid, oleic acid, linoleic acid and linolenic acid, including 40.9% saturated fatty acids and 59.1% unsaturated fatty acids. The lipid composition was similar to that of plant oil, indicating that lipid from oleaginous yeast R. glutinis had potential as the feedstock of biodiesel production. These results demonstrated that a certain concentration of acetic acid need not to be removed in the detoxification process when using lignocelluloses hydrolysate to produce microbial lipid by R. glutinis. PMID:27349116

  2. Automated bar detection in local disc galaxies from the SDSS - The colors of bars

    CERN Document Server

    Consolandi, Guido

    2016-01-01

    This paper describes an automatic isophotal fitting procedure that succeeds, without the support of any visual inspection of neither the images nor the ellipticity/P.A. radial profiles, at extracting a fairly pure sample of barred LTGs among thousands of optical images from the SDSS. The procedure relies on the methods described in Consolandi et al. (2016) to robustly extract the photometrical properties of a large sample of local SDSS galaxies and is tailored to extract bars on the basis of their well-known peculiarities in their P.A. and ellipticity profiles. It has been run on a sample of 5853 galaxies in the Coma and Local supercluster. The procedure extracted for each galaxy a color, an ellipticity and a position angle radial profile of the ellipses fitted to the isophotes. Examining automatically the profiles of 922 face-on late-type galaxies (B/A >0.7) the procedure found that ~ 36 % are barred. The local bar fraction strongly increases with stellar mass. The sample of barred galaxies is used to constr...

  3. Slowly rotating bars-Morphologies introduced by bistability in barred-spiral galactic potentials

    CERN Document Server

    Tsigaridi, L

    2015-01-01

    We investigate the orbital dynamics of a \\textit{barred-spiral} model when the system is rotating slowly and corotation is located beyond the end of the spiral arms. In the characteristic of the central family of periodic orbits we find a "bistable region". In the response model we observe a ring surrounding the bar and spiral arms starting tangential to the ring. This is a morphology resembling barred-spiral systems with inner rings. However, the dynamics associated with this structure in the case we study is different from that of a typical bar ending close to corotation. The ring of our model is round, or rather elongated perpendicular to the bar. It is associated with a folding (an "S" shaped feature) of the characteristic of the central family, which is typical in bistable bifurcations. Along the "S" part of the characteristic we have a change in the orientation of the periodic orbits from a x1-type to a x2-type morphology. The orbits populated in the response model change rather abruptly their orientati...

  4. Production of lipids in 10 strains of Chlorella and Parachlorella, and enhanced lipid productivity in Chlorella vulgaris

    Energy Technology Data Exchange (ETDEWEB)

    Pribyl, Pavel; Cepak, Vladislav [Academy of Sciences of the Czech Republic, Trebon (Czech Republic). Algological Centre and Centre for Bioindication and Revitalization; Zachleder, Vilem [Academy of Sciences of the Czech Republic, Trebon (Czech Republic). Lab. of the Cell Cycles of Algae

    2012-04-15

    We tested 10 different Chlorella and Parachlorella strains under lipid induction growth conditions in autotrophic laboratory cultures. Between tested strains, substantial differences in both biomass and lipid productivity as well as in the final content of lipids were found. The most productive strain (Chlorella vulgaris CCALA 256) was subsequently studied in detail. The availability of nitrates and/or phosphates strongly influenced growth and accumulation of lipids in cells by affecting cell division. Nutrient limitation substantially enhanced lipid productivity up to a maximal value of 1.5 g l{sup -1} day{sup -1}. We also demonstrated the production of lipids through large-scale cultivation of C. vulgaris in a thin layer photobioreactor, even under suboptimal conditions. After 8 days of cultivation, maximal lipid productivity was 0.33 g l{sup -1} day{sup -1}, biomass density was 5.7 g l{sup -1} dry weight and total lipid content was more than 30% dry weight. C. vulgaris lipids comprise fatty acids with a relatively high degree of saturation compared with canola oil offering a possible alternative to the use of higher plant oils. (orig.)

  5. Which bulges are favoured by barred S0 galaxies?

    CERN Document Server

    Barway, Sudhanshu; Vaghmare, Kaustubh; Kembhavi, Ajit K

    2016-01-01

    S0 galaxies are known to host classical bulges with a broad range of size and mass, while some such S0s are barred and some not. The origin of the bars has remained as a long-standing problem -- what made bar formation possible in certain S0s? By analysing a large sample of S0s with classical bulges observed by the Spitzer space telescope, we find that most of our barred S0s host comparatively low-mass classical bulges, typically with bulge-to-total ratio ($B/T$) less than $0.5$; whereas S0s with more massive classical bulges than these do not host any bar. Furthermore, we find that amongst the barred S0s, there is a trend for the longer and massive bars to be associated with comparatively bigger and massive classical bulges -- possibly suggesting bar growth being facilitated by these classical bulges. In addition, we find that the bulge effective radius is always less than the bar effective radius --indicating an interesting synergy between the host classical bulge and bars being maintained while bar growth ...

  6. LIPID PEROXIDATION IN PREECLAMPSIA

    Directory of Open Access Journals (Sweden)

    T.Sharmila Krishna

    2015-03-01

    Full Text Available Hypertension in pregnancy is a leading cause of both maternal and fetal mortality and morbidity. Preeclampsia is characterised by hypertension and proteinuria. Lipid peroxidation is an important factor in the pathophysiology of Preeclampsia. The present study was undertaken to determine Serum Malondialdehyde (MDA levels , a product of lipid peroxidation , in clinically diagnosed Preeclamptic women(n=30 and the values were compared with that of Normotensive pregnant women (n=30 aged between 18-30yrs. All of them were in their third trimester and were primigravida. Serum MDA was estimated by TBARS (thiobarbituric acid reactive substances method. We observed that Serum MDA levels were significantly increased in Preeclamptic women (p <0.000 as compared to that of Normotensive pregnant women . Increased levels of lipid peroxiation product - MDA may contribute to the pathophysiology of Preeclampsia.

  7. Lipid Production from Nannochloropsis.

    Science.gov (United States)

    Ma, Xiao-Nian; Chen, Tian-Peng; Yang, Bo; Liu, Jin; Chen, Feng

    2016-04-01

    Microalgae are sunlight-driven green cell factories for the production of potential bioactive products and biofuels. Nannochloropsis represents a genus of marine microalgae with high photosynthetic efficiency and can convert carbon dioxide to storage lipids mainly in the form of triacylglycerols and to the ω-3 long-chain polyunsaturated fatty acid eicosapentaenoic acid (EPA). Recently, Nannochloropsis has received ever-increasing interests of both research and public communities. This review aims to provide an overview of biology and biotechnological potential of Nannochloropsis, with the emphasis on lipid production. The path forward for the further exploration of Nannochloropsis for lipid production with respect to both challenges and opportunities is also discussed. PMID:27023568

  8. Lipid Ion Channels

    CERN Document Server

    Heimburg, Thomas

    2010-01-01

    The interpretation electrical phenomena in biomembranes is usually based on the assumption that the experimentally found discrete ion conduction events are due to a particular class of proteins called ion channels while the lipid membrane is considered being an inert electrical insulator. The particular protein structure is thought to be related to ion specificity, specific recognition of drugs by receptors and to macroscopic phenomena as nerve pulse propagation. However, lipid membranes in their chain melting regime are known to be highly permeable to ions, water and small molecules, and are therefore not always inert. In voltage-clamp experiments one finds quantized conduction events through protein-free membranes in their melting regime similar to or even undistinguishable from those attributed to proteins. This constitutes a conceptual problem for the interpretation of electrophysiological data obtained from biological membrane preparations. Here, we review the experimental evidence for lipid ion channels...

  9. Lipid management in ramadan.

    Science.gov (United States)

    Slim, Ines; Ach, Koussay; Chaieb, Larbi

    2015-05-01

    During Ramadan fast, Muslims must refrain from smoking, eating, drinking, having sexual activity, and consuming oral medications from sunrise to sunset. It has been previously shown that Ramadan fasting induces favourable changes on metabolic parameters, reduces oxidative stress and inflammation and promotes cardiovascular benefits. Although ill people are exempted from fasting, most patients with chronic diseases are keen on performing this Islamic-ritual. During recent years, Risk stratification and treatment adjustment during Ramadan are well known and structured in several guidelines for patients with diabetes mellitus. Data related to the effect of Ramadan fast on lipid profiles are less known and several controversies have been reported. Here, we focus on lipid profile and lipid management during Ramadan taking into account comorbidities and cardiovascular risk. PMID:26013790

  10. The relation between bar formation, galaxy luminosity, and environment

    CERN Document Server

    Corsini, E M; Sanchez-Janssen, R; Aguerri, J A L; Zarattini, S

    2013-01-01

    We derive the bar fraction in three different environments ranging from the field to Virgo and Coma clusters, covering an unprecedentedly large range of galaxy luminosities (or, equivalently, stellar masses). We confirm that the fraction of barred galaxies strongly depends on galaxy luminosity. We also show that the difference between the bar fraction distributions as a function of galaxy luminosity (and mass) in the field and Coma cluster are statistically significant, with Virgo being an intermediate case. We interpret this result as a variation of the effect of environment on bar formation depending on galaxy luminosity. We speculate that brighter disk galaxies are stable enough against interactions to keep their cold structure, thus, the interactions are able to trigger bar formation. For fainter galaxies the interactions become strong enough to heat up the disks inhibiting bar formation and even destroying the disks. Finally, we point out that the controversy regarding whether the bar fraction depends on...

  11. Photopolymerization of Dienoyl Lipids Creates Planar Supported Poly(lipid) Membranes with Retained Fluidity.

    Science.gov (United States)

    Orosz, Kristina S; Jones, Ian W; Keogh, John P; Smith, Christopher M; Griffin, Kaitlyn R; Xu, Juhua; Comi, Troy J; Hall, H K; Saavedra, S Scott

    2016-02-16

    Polymerization of substrate-supported bilayers composed of dienoylphosphatidylcholine (PC) lipids is known to greatly enhance their chemical and mechanical stability; however, the effects of polymerization on membrane fluidity have not been investigated. Here planar supported lipid bilayers (PSLBs) composed of dienoyl PCs on glass substrates were examined to assess the degree to which UV-initiated polymerization affects lateral lipid mobility. Fluorescence recovery after photobleaching (FRAP) was used to measure the diffusion coefficients (D) and mobile fractions of rhodamine-DOPE in unpolymerized and polymerized PSLBs composed of bis-sorbyl phosphatidylcholine (bis-SorbPC), mono-sorbyl-phosphatidylcholine (mono-SorbPC), bis-dienoyl-phosphatidylcholine (bis-DenPC), and mono-dienoyl phosphatidylcholine (mono-DenPC). Polymerization was performed in both the Lα and Lβ phase for each lipid. In all cases, polymerization reduced membrane fluidity; however, measurable lateral diffusion was retained which is attributed to a low degree of polymerization. The D values for sorbyl lipids were less than those of the denoyl lipids; this may be a consequence of the distal location of polymerizable group in the sorbyl lipids which may facilitate interleaflet bonding. The D values measured after polymerization were 0.1-0.8 of those measured before polymerization, a range that corresponds to fluidity intermediate between that of a Lα phase and a Lβ phase. This D range is comparable to ratios of D values reported for liquid-disordered (Ld) and liquid-ordered (Lo) lipid phases and indicates that the effect of UV polymerization on lateral diffusion in a dienoyl PSLB is similar to the transition from a Ld phase to a Lo phase. The partial retention of fluidity in UV-polymerized PSLBs, their enhanced stability, and the activity of incorporated transmembrane proteins and peptides is discussed. PMID:26794208

  12. (Ln-bar, g)-spaces. General relativity over V4-bar - spaces

    International Nuclear Information System (INIS)

    The results from the considerations of differentiable manifolds with contravariant and covariant affine connections and metrics are specialized for the case of (Ln bar, g)-spaces with metric transport (∇ξ g = 0 for all ξ is T (M), gij;k = 0 and fji = eφ · gji (the s.c. (pseudo)Riemannian spaces with contravariant and covariant symmetric affine connections). Einstein's theory of gravitation is considered in (pseudo)Riemannian spaces with different (not only by sign) contravariant and covariant affine connections ((Vn bar)-spaces, n = 4). The Euler-Lagrange equations and the corresponding energy-momentum tensors (EMT-s) are obtained and compared with the Einstein equations and the EMT-s in V4-spaces. The geodesic and autoparallel equations in V4 bar -spaces are found as different equations in contrast to the case of V4-spaces

  13. 50 CFR Figures 14a and 14b to Part... - Maximum Angle of Deflector Bars With Straight Bars Attached to the Bottom of the Frame and...

    Science.gov (United States)

    2010-10-01

    ... Straight Bars Attached to the Bottom of the Frame and Maximum Angle of Deflector Bars With Bent Bars Attached to the Bottom of the Frame 14a Figures 14a and 14b to Part 223 Wildlife and Fisheries NATIONAL... 223—Maximum Angle of Deflector Bars With Straight Bars Attached to the Bottom of the Frame and...

  14. The effect of charged lipids on bacteriorhodopsin membrane reconstitution and its photochemical activities

    International Nuclear Information System (INIS)

    Bacteriorhodopsin (BR) was reconstituted into artificial lipid membrane containing various charged lipid compositions. The proton pumping activity of BR under flash and continuous illumination, proton permeability across membrane, as well as the decay kinetics of the photocycle intermediate M412 were studied. The results showed that lipid charges would significantly affect the orientation of BR inserted into lipid membranes. In liposomes containing anionic lipids, BRs were more likely to take natural orientation as in living cells. In neutral or positively charged liposomes, most BRs were reversely assembled, assuming an inside out orientation. Moreover, the lipids charges also affect BR's M intermediate kinetics, especially the slow component in M intermediate decay. The half-life M412s increased significantly in BRs in liposomes containing cationic lipids, while decreased in those in anionic liposomes

  15. Lipids in airway secretions

    International Nuclear Information System (INIS)

    Lipids form a significant portion of airway mucus yet they have not received the same attention that epithelial glycoproteins have. We have analysed, by thin layer chromatography, lipids present in airway mucus under 'normal' and hypersecretory (pathological) conditions.The 'normals' included (1) bronchial lavage obtained from healthy human volunteers and from dogs and (2) secretions produced ''in vitro'' by human (bronchial) and canine (tracheal) explants. Hypersecretory mucus samples included (1) lavage from dogs made bronchitic by exposure to SO2, (2) bronchial aspirates from acute and chronic tracheostomy patients, (3) sputum from patients with cystic fibrosis and chronic bronchitis and (4) postmortem secretions from patients who died from sudden infant death syndrome (SIDS) or from status asthmaticus. Cholesterol was found to be the predominant lipid in 'normal' mucus with lesser amounts of phospholipids. No glycolipids were detected. In the hypersecretory mucus, in addition to neutral and phospholipids, glycolipids were present in appreciable amounts, often the predominant species, suggesting that these may be useful as markers of disease. Radioactive precursors 14C acetate and 14C palmitate were incorporated into lipids secreted ''in vitro'' by canine tracheal explants indicating that they are synthesised by the airway. (author)

  16. Lipids in airway secretions

    Energy Technology Data Exchange (ETDEWEB)

    Bhaskar, K.R.; DeFeudis O' Sullivan, D.; Opaskar-Hincman, H.; Reid, L.M.

    1987-01-01

    Lipids form a significant portion of airway mucus yet they have not received the same attention that epithelial glycoproteins have. We have analysed, by thin layer chromatography, lipids present in airway mucus under 'normal' and hypersecretory (pathological) conditions.The 'normals' included (1) bronchial lavage obtained from healthy human volunteers and from dogs and (2) secretions produced ''in vitro'' by human (bronchial) and canine (tracheal) explants. Hypersecretory mucus samples included (1) lavage from dogs made bronchitic by exposure to SO/sub 2/, (2) bronchial aspirates from acute and chronic tracheostomy patients, (3) sputum from patients with cystic fibrosis and chronic bronchitis and (4) postmortem secretions from patients who died from sudden infant death syndrome (SIDS) or from status asthmaticus. Cholesterol was found to be the predominant lipid in 'normal' mucus with lesser amounts of phospholipids. No glycolipids were detected. In the hypersecretory mucus, in addition to neutral and phospholipids, glycolipids were present in appreciable amounts, often the predominant species, suggesting that these may be useful as markers of disease. Radioactive precursors /sup 14/C acetate and /sup 14/C palmitate were incorporated into lipids secreted ''in vitro'' by canine tracheal explants indicating that they are synthesised by the airway.

  17. Lake Superior lipids

    Data.gov (United States)

    U.S. Environmental Protection Agency — Fish chemistry data (d13C, d15N, C:N, lipid content) published in Rapid Commun. Mass Spectrom. 2015, 29, 2069–2077 DOI: 10.1002/rcm.7367 This dataset is associated...

  18. High fat intake and equine lipid metabolism

    OpenAIRE

    Geelen, Suzanne Nicole Jeanne

    2002-01-01

    This thesis deals with the influence of fat feeding on lipid metabolism in horses. Highfat diets have attained considerable interest as a potential tool to improve performance.Many factors affect performance so that large numbers of horses are needed to unequivocally determine the effect of diet on performance. In practice, the execution of trials on diet in relation to performance is not possible. However, based on the reported effects of nutrition on metabolism, it should be possible to pre...

  19. Amphotericin B Lipid Complex Injection

    Science.gov (United States)

    Amphotericin B lipid complex injection is used to treat serious, possibly life-threatening fungal infections in people who did ... respond or are unable to tolerate conventional amphotericin B therapy. Amphotericin B lipid complex injection is in ...

  20. Dependence of Barred Galaxy Fraction on Galaxy Properties and Environment

    CERN Document Server

    Lee, Gwang-Ho; Lee, Myung Gyoon; Choi, Yun-Young

    2011-01-01

    We investigate the dependence of occurrence of bars in galaxies on galaxy properties and environment. We use a volume-limited sample of 33,391 galaxies brighter than $M_{r}=-19.5+5$log$h$ at $0.02\\le z\\le0.05489$, drawn from the SDSS DR 7. We classify the galaxies into early and late types, and identify bars by visual inspection. Among 10,674 late-type galaxies with axis ratio $b/a>0.60$, we find 3,240 barred galaxies ($f_{bar}=30.4%$) which divide into 2,542 strong bars ($f_{SB1}=23.8%$) and 698 weak bars ($f_{SB2}=6.5%$). We find that $f_{SB1}$ increases as $u-r$ color becomes redder, and that it has a maximum value at intermediate velocity dispersion ($\\sigma\\simeq$150 km s$^{-1}$). This trend suggests that strong bars are dominantly hosted by intermediate-mass systems. Weak bars prefer bluer galaxies with lower mass and lower concentration. In the case of strong bars, their dependence on the concentration index appears only for massive galaxies with $\\sigma>150$ km s${}^{-1}$. We also find that $f_{bar}$ ...

  1. How can double-barred galaxies be long-lived?

    CERN Document Server

    Wozniak, Herve

    2015-01-01

    Double-barred galaxies account for almost one third of all barred galaxies, suggesting that secondary stellar bars, which are embedded in large-scale primary bars, are long-lived structures. However, up to now it has been hard to self-consistently simulate a disc galaxy that sustains two nested stellar bars for longer than a few rotation periods. N-body/hydrodynamical simulations including star formation recipes have been performed. Their properties have been compared with the most recent observational data in order to prove that they are representative of double-barred galaxies, even SB0. Overlaps in dynamical resonances and bar modes have been looked for using Fourier spectrograms. Double-barred galaxies have been successfully simulated with lifetimes as long as 7 Gyr. The stellar population of the secondary bar is younger on average than for the primary large-scale bar. An important feature of these simulations is the absence of any resonance overlap for several Gyr. In particular, there is no overlap betw...

  2. AGN spiral galaxies in groups: effects of bars

    CERN Document Server

    Alonso, Sol; Lambas, Diego García

    2014-01-01

    We explore properties of barred active spiral galaxies in groups selected from the SDSS-DR7, with the aim of assessing the effects of bars on AGN and the role of the high density environment. We identified barred active galaxies that reside in groups from SDSS-DR7 group catalog. To provide a suitable quantification of the effects of bars, a reliable control sample of unbarred active galaxies in high density environments with similar redshift, magnitude, morphology, and bulge size distributions was constructed. We found that the fraction of barred AGN galaxies in groups (~ 38 %) is higher than those in the total barred AGN sample ( ~ 28 %), indicating that AGN spiral galaxies in groups are more likely to be barred than those in the field. We also found that barred AGN galaxies are more concentrated towards the group centers than the other unbarred AGN group members. In addition, barred AGN host galaxies show an excess of population dominated by red colors suggesting that bars produce an importanteffect on gala...

  3. The Structure of the Milky Way's Bar Outside the Bulge

    CERN Document Server

    Wegg, Christopher; Portail, Matthieu

    2015-01-01

    While it is incontrovertible that the inner Galaxy contains a bar, its structure near the Galactic plane has remained uncertain, where extinction from intervening dust is greatest. We investigate here the Galactic bar outside the bulge, the long bar, using red clump giant (RCG) stars from UKIDSS, 2MASS, VVV, and GLIMPSE. We match and combine these surveys to investigate a wide area in latitude and longitude, |b|<9deg and |l|<40deg. We find: (1) The bar extends to l~25deg at |b|~5deg from the Galactic plane, and to l~30deg at lower latitudes. (2) The long bar has an angle to the line-of-sight in the range (28-33)deg, consistent with studies of the bulge at |l|<10deg. (3) The scale-height of RCG stars smoothly transitions from the bulge to the thinner long bar. (4) There is evidence for two scale heights in the long bar. We find a ~180pc thin bar component reminiscent of the old thin disk near the sun, and a ~45pc super-thin bar component which exists predominantly towards the bar end. (5) Constructing...

  4. Bars and secular evolution in disk galaxies: Theoretical input

    CERN Document Server

    Athanassoula, E

    2012-01-01

    Bars play a major role in driving the evolution of disk galaxies and in shaping their present properties. They cause angular momentum to be redistributed within the galaxy, emitted mainly from (near-)resonant material at the inner Lindblad resonance of the bar, and absorbed mainly by (near-)resonant material in the spheroid (i.e., the halo and, whenever relevant, the bulge) and in the outer disk. Spheroids delay and slow down the initial growth of the bar they host, but, at the later stages of the evolution, they strengthen the bar by absorbing angular momentum. Increased velocity dispersion in the (near-)resonant regions delays bar formation and leads to less strong bars. When bars form they are vertically thin, but soon their inner parts puff up and form what is commonly known as the boxy/peanut bulge. This gives a complex and interesting shape to the bar which explains a number of observations and also argues that the COBE/DIRBE bar and the Long bar in our Galaxy are, respectively, the thin and the thick p...

  5. Finite Element Simulations to Explore Assumptions in Kolsky Bar Experiments.

    Energy Technology Data Exchange (ETDEWEB)

    Crum, Justin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-08-05

    The chief purpose of this project has been to develop a set of finite element models that attempt to explore some of the assumptions in the experimental set-up and data reduction of the Kolsky bar experiment. In brief, the Kolsky bar, sometimes referred to as the split Hopkinson pressure bar, is an experimental apparatus used to study the mechanical properties of materials at high strain rates. Kolsky bars can be constructed to conduct experiments in tension or compression, both of which are studied in this paper. The basic operation of the tension Kolsky bar is as follows: compressed air is inserted into the barrel that contains the striker; the striker accelerates towards the left and strikes the left end of the barrel producing a tensile stress wave that propogates first through the barrel and then down the incident bar, into the specimen, and finally the transmission bar. In the compression case, the striker instead travels to the right and impacts the incident bar directly. As the stress wave travels through an interface (e.g., the incident bar to specimen connection), a portion of the pulse is transmitted and the rest reflected. The incident pulse, as well as the transmitted and reflected pulses are picked up by two strain gauges installed on the incident and transmitted bars as shown. By interpreting the data acquired by these strain gauges, the stress/strain behavior of the specimen can be determined.

  6. Neutralino annihilation to q \\bar q g

    CERN Document Server

    Barger, V; Logan, H; Shaughnessy, G; Barger, Vernon; Keung, Wai-Yee; Logan, Heather; Shaughnessy, Gabe

    2006-01-01

    We compute the cross section for \\chi\\chi \\to q \\bar q g at order \\alpha_s^2/M_{\\widetilde q}^6 arising from interference between the tree-level and loop-induced processes. This interference term is the same order in \\alpha_s as \\chi\\chi \\to gg; for mass degenerate squarks M_{\\widetilde q_R} = M_{\\widetilde q_L} = M_{\\widetilde q} we find v_{\\rm rel} \\sigma_{\\rm int} = [-2 m_{\\chi}^2/3 M_{\\widetilde q}^2] v_{\\rm rel} \\sigma (\\chi\\chi \\to gg).

  7. System analysis of bar code laser scanner

    Science.gov (United States)

    Wang, Jianpu; Chen, Zhaofeng; Lu, Zukang

    1996-10-01

    This paper focuses on realizing the three important aspects of bar code scanner: generating a high quality scanning light beam, acquiring a fairly even distribution characteristic of light collection, achieving a low signal dynamic range over a large depth of field. To do this, we analyze the spatial distribution and propagation characteristics of scanning laser beam, the vignetting characteristic of optical collection system and their respective optimal design; propose a novel optical automatic gain control method to attain a constant collection over a large working depth.

  8. Warp evidences in precessing galactic bar models

    OpenAIRE

    Sanchez-Martin, Patricia; Romero-Gomez, Merce; Masdemont, Josep J.

    2016-01-01

    Most galaxies have a warped shape when they are seen from an edge-on point of view. The reason for this curious form is not completely known so far and in this work we apply dynamical system tools to contribute to its explanation. Starting from a simple, but realistic, model formed by a bar and a disc, we study the effect produced by a small misalignment between the angular momentum of the system and its angular velocity. To this end, a precession model is developed and considered, assuming t...

  9. A Distinct Structure Inside the Galactic Bar

    OpenAIRE

    Nishiyama, Shogo; Nagata, Tetsuya; Baba, Daisuke; Haba, Yasuaki; Kadowaki, Ryota; Kato, Daisuke; Kurita, Mikio; Nagashima, Chie; Nagayama, Takahiro; Murai, Yuka; Nakajima, Yasushi; Tamura, Motohide; Nakaya, Hidehiko; Sugitani, Koji; Naoi, Takahiro

    2005-01-01

    We present the result of a near-infrared (J H Ks) survey along the Galactic plane, -10.5deg < l < +10.5deg and b=+1.0deg, with the IRSF 1.4m telescope and the SIRIUS camera. Ks vs. H-Ks color-magnitude diagrams reveal a well-defined population of red clump (RC) stars whose apparent magnitude peak changes continuously along the Galactic plane, from Ks=13.4 at l=-10deg to Ks=12.2 at l=+10deg after dereddening. This variation can be explained by the bar-like structure found in previous studies, ...

  10. $B$--$\\bar B$ Mixing Results

    CERN Document Server

    Daoudi, M

    1999-01-01

    A review of B B-bar mixing results at the end of July 1999 is presented. Emphasis is put on recent measurements of Delta-Md and Delta-Ms. For Delta-Md, the new world average is Delta-Md = 0.473 +- 0.016 ps-1. For Delta-Ms, the new world average 95% CL limit is 12.4 ps-1, with a sensitivity of 14.2 ps-1. Other related results are covered very briefly.

  11. The Pattern Speed of the Galactic Bar

    OpenAIRE

    Dehnen, Walter

    1999-01-01

    Most late-type stars in the solar neighborhood have velocities similar to the local standard of rest (LSR), but there is a clearly separated secondary component corresponding to a slower rotation and a mean outward motion. Detailed simulations of the response of a stellar disk to a central bar show that such a bi-modality is expected from outer-Lindblad resonant scattering. When constraining the run of the rotation curve by the proper motion of Sgr A* and the terminal gas velocities, the valu...

  12. BarLaurean mahdollisuudet saavuttaa Joutsenmerkki

    OpenAIRE

    Järveläinen, Tuomas; Paavola, Salme

    2009-01-01

    Joutsenmerkki on vapaaehtoinen yhteispohjoismainen Ympäristömerkki. Opinnäytetyö on osa kehittämistyötä, jonka tavoitteena on hakea Joutsenmerkintää BarLaurean toiminnalle. Joutsenmerkin anomiseen tähtäävät toimenpiteet on aloitettu keväällä 2009 tekemällä aiheesta alustava toimintasuunnitelma. Opinnäytetyön tavoitteena on soveltaa käytäntöön toimintasuunnitelmassa kuvattuja toimenpiteitä, jotka dokumentoidaan Joutsenmerkkikansioon osana Joutsenmerkki-hakemusta. Opinnäytetyön tavoitteena ...

  13. Search for the decay of a B0 or B0bar meson to K*0bar K0 or K*0 K0bar

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.

    2006-06-27

    The authors present a search for the decay of a B{sup 0} or {bar B}{sup 0} meson to a {bar K}*{sup 0} K{sup 0} or K*{sup 0} {bar K}{sup 0} final state, using a sample of approximately 232 million B{bar B} events collected with the BABAR detector at the PEP-II asymmetric energy e{sup +}e{sup -} collider at SLAC. The measured branching fraction is {Beta}(B{sup 0} {yields} {bar K}*{sup 0} K{sup 0}) + {Beta}(B{sup 0} {yields} K*{sup 0} {bar K}{sup 0}) = (0.2{sub -0.8, -0.3}{sup +0.9, +0.1}) x 10{sup -6}. They obtain the following upper limit for the branching fraction at 90% confidence level: {Beta}(B{sup 0} {yields} {bar K}*{sup 0} K{sup 0}) + {Beta}(B{sup 0} {yields} K*{sup 0} {bar K}{sup 0}) < 1.9 x 10{sup -6}. They use our result to constrain the Standard Model prediction for the deviation of the CP asymmetry in B{sup 0} {yields} {phi}K{sup 0} from sin 2{beta}.

  14. Effects of packaging on the performances of high brightness 9xx nm CW mini-bar diode lasers

    Science.gov (United States)

    Li, Xiaoning; Wang, Jingwei; Feng, Feifei; Liu, Yalong; Yu, Dongshan; Zhang, Pu; Liu, Xingsheng

    2015-02-01

    9xx nm CW mini-bar diode lasers and stacks with high brightness and reliability are desired for pumping fiber lasers and direct fiber coupling applications. For the traditional cm-bar with 1mm-2mm cavity, it can provide CW output power up to 80W-100W and high reliability, whereas the brightness is relatively low. In comparison, mini-bar based diode lasers with 4mm cavity offer a superior performance balance between power, brightness, and reliability. However, the long cavity and large footprint of mini-bar diode laser renders its sensitivity towards thermal stress formed in packaging process, which directly affects the performances of high bright mini-bar diode lasers. In this work, the thermal stress correlating with package structure and packaging process are compared and analyzed. Based on the experiment and analysis results, an optimized package structure of CW 60W 976 nm mini-bar diode lasers is designed and developed which relieves thermal stress.

  15. Measurement of Parasitic Inductances in the Bus-Bar Assembly of a High Power Voltage Source Converter

    Science.gov (United States)

    Datta, Aniket; Narayanan, G.

    2016-05-01

    Insulated gate bipolar transistor (IGBT) based voltage source converters use copper plates with insulating sheets in between them (sandwich bus-bar arrangement) for connecting the different device terminals in the power circuit. In such converters, the parasitic inductances in the power circuit are crucial as they cause overvoltage spikes across the device. Also, the parasitics affect the current sharing between IGBTs when they are connected in parallel in high power converters. The conduction path through plates and fasteners in the bus-bar assembly is three-dimensional and quite complex, making analytical evaluation of the stray inductance quite challenging. The first objective here is to present a simple experimental setup and experimental procedure, which are convenient for power electronic engineers, to measure the bus-bar inductance. The next objective is to carry out experimental studies on the inductances offered by different components and sub-assemblies in a bus-bar assembly. This includes evaluation of inductances of the different conduction paths in typical bus-bar plates. The third objective is to experimentally evaluate the parasitic inductances in the bus-bar assembly of a commercial 250 kVA high power converter. Each leg of this converter consists of two 300 A/1200 V IGBTs connected in parallel. The effective inductance seen by the individual device modules are determined experimentally.

  16. Lanolin-derived lipid mixtures mimic closely the lipid composition and organization of vernix caseosa lipids.

    Science.gov (United States)

    Rissmann, Robert; Oudshoorn, Marion H M; Kocks, Elise; Hennink, Wim E; Ponec, Maria; Bouwstra, Joke A

    2008-10-01

    The aim of the present study was to use semi-synthetic lipid mixtures to mimic the complex lipid composition, organization and thermotropic behaviour of vernix caseosa (VC) lipids. As VC shows multiple protecting and barrier supporting properties before and after birth, it is suggested that a VC substitute could be an innovative barrier cream for barrier deficient skin. Lanolin was selected as the source of the branched chain sterol esters and wax esters--the main lipid classes of VC. Different lipid fractions were isolated from lanolin and subsequently mixed with squalene, triglycerides, cholesterol, ceramides and fatty acids to generate semi-synthetic lipid mixtures that mimic the lipid composition of VC, as established by high-performance thin-layer chromatography. Differential scanning calorimetry and Fourier transform infrared spectroscopy investigations revealed that triglycerides play an important role in the (lateral) lipid organization and thermotropic behaviour of the synthetic lipid mixtures. Excellent resemblance of VC lipids was obtained when adding unsaturated triglycerides. Moreover, these lipid mixtures showed similar long range ordering as VC. The optimal lipid mixture was evaluated on tape-stripped hairless mouse skin in vivo. The rate of barrier recovery was increased and comparable to VC lipid treatment. PMID:18655769

  17. Impact of monoolein on aquaporin1-based supported lipid bilayer membranes

    Science.gov (United States)

    Wang, Zhining; Wang, Xida; Ding, Wande; Wang, Miaoqi; Qi, Xin; Gao, Congjie

    2015-08-01

    Aquaporin (AQP) based biomimetic membranes have attracted considerable attention for their potential water purification applications. In this paper, AQP1 incorporated biomimetic membranes were prepared and characterized. The morphology and structure of the biomimetic membranes were characterized by in situ atomic force microscopy (AFM), infrared absorption spectroscopy, fluorescence microscopy, and contact angle measurements. The nanofiltration performance of the AQP1 incorporated membranes was investigated at 4 bar by using 2 g l-1 NaCl as feed solution. Lipid mobility plays an important role in the performance of the AQP1 incorporated supported lipid bilayer (SLB) membranes. We demonstrated that the lipid mobility is successfully tuned by the addition of monoolein (MO). Through in situ AFM and fluorescence recovery after photo-bleaching (FRAP) measurements, the membrane morphology and the molecular mobility were studied. The lipid mobility increased in the sequence DPPC rejection. This study may provide some useful insights for improving the water purification performance of biomimetic membranes.

  18. Fatty Acids and Bioactive Lipids of Potato Cultivars: An Overview.

    Science.gov (United States)

    Ramadan, Mohamed Fawzy; Oraby, Hesahm Farouk

    2016-01-01

    Potato tuber is a highly nutritious, wherein genotype and environmental differences are known to exist in the shape, size and nutritional value of potatoes. Owing to its high consumption, potato could be an ideal carrier of health-promoting phytochemicals. Potato cultivars contain many bioactive lipidic compounds such as fatty acids, glycolipids, phospholipids, sterols, tocols and carotenoids, which are highly desirable in diet because of their health-promoting effects. In the scientific literature, information on the content and profile of bioactive lipidic compounds in potato cultivars are few. The concentration and stability of bioactive lipids are affected by many factors such as genotype, agronomic factors, postharvest storage, cooking and processing conditions. In this review levels and composition of bioactive lipids in terms of lipid classes, fatty acids, phytosterols, tocopherols, and caroteinoids distribution in different potato cultivars including genetically modified potato (GMP) were highlighted and discussed. In addition, factors affecting bioactive lipids levels, stability and health benefits are reviewed. In consideration of potential nutritional value, detailed knowledge on lipids of potato cultivars is of major importance. PMID:27250559

  19. Effects of Concrete on Propagation Characteristics of Guided Wave in Steel Bar Embedded in Concrete

    OpenAIRE

    Zhupeng Zheng; Ying Lei

    2014-01-01

    Techniques based on ultrasonic guided waves (UGWs) play important roles in the structural health monitoring (SHM) of large-scale civil infrastructures. In this paper, dispersion equations of longitudinal wave propagation in reinforced concrete member are investigated for the purpose of monitoring steels embedded in concrete. For a steel bar embedded in concrete, not the velocity but the attenuation dispersion curves will be affected by the concrete. The effects of steel-to-concrete shear modu...

  20. Experimental issues and interpretation of the necking phenomena in the dynamic characterization via Hopkinson bar

    OpenAIRE

    Mirone Giuseppe; Corallo Domenico

    2015-01-01

    The usual procedures for processing experimental data from Hopkinson bars (HB) are based on modeling hypotheses which, in some cases, may lead to considerable approximations. The effects of the specimen geometry and of the necking are analysed, both experimentally and by FE analyses, for assessing how much the conventional values of strain rate, strain and stress, based on strain gauges readings along the HB, are affected by approximations in different testing conditions. Also, from the way t...

  1. An Optical Method of Strain Measurement in the Split Hopkinson Pressure Bar

    OpenAIRE

    Swantek, Steven David

    2000-01-01

    The split Hopkinson pressure bar (SHPB) continues to be one of the most common methods of testing materials at medium rates of strain. Elevated rates of strain, such as those found in impact and explosive applications, have been shown to induce phenomena such as strain hardening and phase transitions that can significantly affect the strength of most materials [14]. Due to its relative simplicity and robustness, the SHPB remains one of the preferred platforms for evaluating mechanical prope...

  2. Hepatitis C Virus Life Cycle and Lipid Metabolism

    Directory of Open Access Journals (Sweden)

    Costin-Ioan Popescu

    2014-12-01

    Full Text Available Hepatitis C Virus (HCV infects over 150 million people worldwide. In most cases HCV infection becomes chronic, causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. HCV affects the cholesterol homeostasis and at the molecular level, every step of the virus life cycle is intimately connected to lipid metabolism. In this review, we present an update on the lipids and apolipoproteins that are involved in the HCV infectious cycle steps: entry, replication and assembly. Moreover, the result of the assembly process is a lipoviroparticle, which represents a peculiarity of hepatitis C virion. This review illustrates an example of an intricate virus-host interaction governed by lipid metabolism.

  3. Plant lipid transfer proteins : Evolution, expression and function

    OpenAIRE

    Edstam, Monika

    2013-01-01

    The plant non-specific lipid transfer proteins (nsLTPs) are known for the ability to transfer different lipids in vitro, but their in vivo functions have not yet been elucidated. They seem to play a role in the defense against biotic and abiotic stresses; the gene expression of nsLTPs is often upregulated when exposed to stresses. Further, two different nsLTPs have been shown to affect the lipid composition of the plant cuticle, a structure acting as a protective barrier. However, more eviden...

  4. Automated multisyringe stir bar sorptive extraction using robust montmorillonite/epoxy-coated stir bars.

    Science.gov (United States)

    Ghani, Milad; Saraji, Mohammad; Maya, Fernando; Cerdà, Víctor

    2016-05-01

    Herein we present a simple, rapid and low cost strategy for the preparation of robust stir bar coatings based on the combination of montmorillonite with epoxy resin. The composite stir bar was implemented in a novel automated multisyringe stir bar sorptive extraction system (MS-SBSE), and applied to the extraction of four chlorophenols (4-chlorophenol, 2,4-dichlorophenol, 2,4,6-trichlorophenol and pentachlorophenol) as model compounds, followed by high performance liquid chromatography-diode array detection. The different experimental parameters of the MS-SBSE, such as sample volume, selection of the desorption solvent, desorption volume, desorption time, sample solution pH, salt effect and extraction time were studied. Under the optimum conditions, the detection limits were between 0.02 and 0.34μgL(-1). Relative standard deviations (RSD) of the method for the analytes at 10μgL(-1) concentration level ranged from 3.5% to 4.1% (as intra-day RSD) and from 3.9% to 4.3% (as inter-day RSD at 50μgL(-1) concentration level). Batch-to-batch reproducibility for three different stir bars was 4.6-5.1%. The enrichment factors were between 30 and 49. In order to investigate the capability of the developed technique for real sample analysis, well water, wastewater and leachates from a solid waste treatment plant were satisfactorily analyzed. PMID:27062720

  5. The LHCb pentaquark as a $\\bar{D}^*\\Sigma_c-\\bar{D}^*\\Sigma_c^*$ molecular state

    CERN Document Server

    Roca, L; Oset, E

    2015-01-01

    We perform a theoretical analysis of the $\\Lambda_b \\to J/\\psi K^- p$ reaction from where a recent LHCb experiment extracts a $\\Lambda(1405)$ contribution in the $K^- p$ spectrum close to threshold and two baryon states of hidden charm in the $J/\\psi\\,p$ spectrum. We recall that baryon states of this type have been theoretically predicted matching the mass, width and $J^P$ of the experiment, concretely some states built up from the $J/\\psi\\, N$, $\\bar D^* \\Lambda_c$, $\\bar D^* \\Sigma_c$, $\\bar D \\Sigma^*_c$ and $\\bar D^* \\Sigma^*_c$ coupled channels. We assume that the observed narrow state around 4450 MeV has this nature and we are able to describe simultaneously the shapes and relative strength of the the $K^- p$ mass distribution close to threshold and the peak of the $J/\\psi\\,p$ distribution, with values of the $J/\\psi\\, p$ coupling to the resonance in line with the theoretical ones. The non trivial matching of many properties gives support to a $J^P=3/2^-$ assignment to this state and to its nature as a ...

  6. Study of the ρ-bar, β-bar and Λ parameters of a light-water reactor

    International Nuclear Information System (INIS)

    The kinetic and perturbation equations are derived from the time-dependent transport equation. Kinetic equations depend only on the ratios a = ρ-bar/β-bar and b = β-bar/Λ, which are definite, while the reactivity ρ-bar, the delayed neutron fraction (β-bar and the generation time Λ are expressed in terms of an arbitrary function I. The 'static' definitions of these parameters, which reduce kinetic problems to a set of purely term dependent equations, introduce the effective fraction β-bar. One way of determining experimentally the ratio b is presented; it consists in analysing the power transient after a rapid variation of the reactivity, caused by the implosion of an empty glass-bull. A simple interpretation is proposed. The apparatus can be transformed easily into a reactimeter. The value of the effective delayed neutron fraction β-bar has been determined by averaging the reactivity effects of a copper sheet through out the reactor core. Experimental results: b = β-bar/Λ = 129 s-1 and β-bar 795.10-5, have been determined on a light-water moderated, enriched-uranium fuelled reactor. The calculated values of the effectiveness of delayed neutrons γ β-bar/β 1.23 and the generation time Λ 59.10-6s agrees fairly well with the experimental results. (author)

  7. Stainless steel for reinforcing bar concrete

    International Nuclear Information System (INIS)

    Where corrosion resisting reinforcing bar is required, stainless steel has been employed for many applications. The longest recorded use so far is over 75 years for a restoration project in the United Kingdom. Other areas are highway bridge decks, retaining walls, tunnels, pier and overpass structures all of which use stainless steel to prevent corrosion and extend structure life. Carbon steel rebar leads to premature failure via concrete spalling that results in excessive repair, high cost, traffic delay and commerce disruption. Selection of stainless steel is based on its corrosion resistance, strength and long life. Installed cost using stainless steel reinforcing barranges from one to fifteen percent depending on structure complexity. Life Cycle Cost calculations reveal when stainless steel reinforcing bar is factored into the design, with a life expectancy up to 125 years, the alloy is cost effective. Data will be exhibited relative to mechanical and physical properties of stainless steel compared to carbon steel rebar. Some stainless rebar applications around the World will be discussed in addition to laboratory and field test results with U-bent stainless steel specimens embedded in concrete. Comments will also be made relative to the environment, lengthened journeys, delivery delay, fuel burned as vehicles sit at idle, drilling, blasting, crushing and transport of aggregate, cement and the attendant power units to manufacture these items for reconstruction. (author)

  8. Orbital structure in barred spiral galaxies

    CERN Document Server

    Harsoula, Maria; 10.1111/j.1365-2966.2009.14427.x

    2010-01-01

    We study the orbital structure in a series of self-consistent $N$-body configurations simulating rotating barred galaxies with spiral and ring structures. We perform frequency analysis in order to measure the angular and the radial frequencies of the orbits at two different time snapshots during the evolution of each $N$-body system. The analysis is done separately for the regular and the chaotic orbits. We thereby identify the various types of orbits, determine the shape and percentages of the orbits supporting the bar and the ring/spiral structures, and study how the latter quantities change during the secular evolution of each system. Although the frequency maps of the chaotic orbits are scattered, we can still identify concentrations around resonances. We give the distributions of frequencies of the most important populations of orbits. We explore the phase space structure of each system using projections of the 4D surfaces of section. These are obtained via the numerical integration of the orbits of test...

  9. Barómetro industrial LEON 50

    Directory of Open Access Journals (Sweden)

    Javier Álvarez Martínez

    2005-12-01

    Full Text Available El Barómetro indusrial LEON 50 es un trabajo de investigación que tiene como objetivo esencial identificar características patrimoniales, financieras y económicas de una muestra de empresas que actúan dentro de la industria leonesa. El soporte de este estudio empírico es la información contable anual auditada que depositan en el Registro Mercantil las empresas integrantes de la muestra, recogida básicamente en el balance de situación, la cuenta de pérdidas y ganacias y el cuadro de finaciación referidos al bienio 2001-02. En esencia, el Barómetro Industrial LEON 50 pretende ser un avance en el análisis, diagnóstico y mejor conocimiento de la industria regional, aportando una visión actualizada sobre estrategias y pautas de actuación empresarial que serán objeto de observación en períodos

  10. Asymptotic Orbits in Barred Spiral Galaxies

    CERN Document Server

    Harsoula, Maria; Contopoulos, George

    2010-01-01

    We study the formation of the spiral structure of barred spiral galaxies, using an $N$-body model. The evolution of this $N$-body model in the adiabatic approximation maintains a strong spiral pattern for more than 10 bar rotations. We find that this longevity of the spiral arms is mainly due to the phenomenon of stickiness of chaotic orbits close to the unstable asymptotic manifolds originated from the main unstable periodic orbits, both inside and outside corotation. The stickiness along the manifolds corresponding to different energy levels supports parts of the spiral structure. The loci of the disc velocity minima (where the particles spend most of their time, in the configuration space) reveal the density maxima and therefore the main morphological structures of the system. We study the relation of these loci with those of the apocentres and pericentres at different energy levels. The diffusion of the sticky chaotic orbits outwards is slow and depends on the initial conditions and the corresponding Jaco...

  11. Deriving the pattern speed using dynamical modelling of gas flows in barred galaxies

    CERN Document Server

    Perez, I; Fux, R; Zurita, A

    2010-01-01

    In this paper we analyse the methodology to derive the bar pattern speed from dynamical simulations. The results are robust to the changes in the vertical-scale height and in the mass-to-light (M/L) ratios. There is a small range of parameters for which the kinematics can be fitted. We have also taken into account the use of different type of dynamical modelling and the effect of using 2-D vs 1-D models in deriving the pattern speeds. We conclude that the derivation of the bar streaming motions and strength and position of shocks is not greatly affected by the fluid dynamical model used. We show new results on the derivation of the pattern speed for NGC 1530. The best fit pattern speed is around 10 km/s/kpc, which corresponds to a R_cor/R_bar = 1.4, implying a slower bar than previously derived from more indirect assumptions. With this pattern speed, the global and most local kinematic features are beautifully reproduced. However, the simulations fail to reproduce the velocity gradients close to some bright H...

  12. Spending too much time at the Galactic bar: chaotic fanning of the Ophiuchus stream

    CERN Document Server

    Price-Whelan, Adrian M; Johnston, Kathryn V; Rix, Hans-Walter

    2016-01-01

    The Ophiuchus stellar stream is peculiar: (1) its length is short given the age of its constituent stars, and (2) several probable member stars that lie close in both sky position and velocity have dispersions in these dimensions that far exceed those seen within the stream. The stream's proximity to the Galactic center suggests that the bar must have a significant influence on its dynamical history: The triaxiality and time-dependence of the bar may generate chaotic orbits in the vicinity of the stream that can greatly affect its morphology. We explore this hypothesis with models of stream formation along orbits consistent with Ophiuchus' properties in a Milky Way potential model that includes a rotating bar. We find that in all choices for the rotation parameters of the bar, orbits fit to the stream are strongly chaotic. Mock streams generated along these orbits qualitatively match the observed properties of the stream: because of chaos, stars stripped early generally form low-density, high-dispersion "fans...

  13. Identification of Drivers of Liking for Bar-Type Snacks Based on Individual Consumer Preference.

    Science.gov (United States)

    Kim, Mina K; Greve, Patrick; Lee, Youngseung

    2016-01-01

    Understanding consumer hedonic responses on food products are of greatest interests in global food industry. A global partial least square regression (GPLSR) had been well accepted method for understanding consumer preferences. Recently, individual partial least square regression (IPLSR) was accepted as an alternative method of predicting consumer preferences on given food product, because it utilizes the individual differences on product acceptability. To improve the understanding of what constitutes bar-type snack preference, the relationship between sensory attributes and consumer overall liking for 12 bar-type snacks was determined. Sensory attributes that drive consumer product likings were analyzed using averaged-consumer data by GPLSR. To facilitate the interpretation of individual consumer liking, a dummy matrix for the significant weighted regression coefficients of each consumer derived from IPLSR was created. From the application of GPLSR and IPLSR, current study revealed that chocolate and cereal-flavored bars were preferred over fruit-flavored bars. Attributes connected to chocolate flavor positively influenced consumer overall likings on the global and individual consumer levels. Textural attributes affected liking only on the individual level. To fully capture the importance of sensory attributes on consumer preference, the use of GPLSR in conjunction with IPLSR is recommended. PMID:26605753

  14. Anti-seismic behavior of HRB400 reinforced steel bars

    Institute of Scientific and Technical Information of China (English)

    QIN Bin; SHENG Guang-min; GONG Shi-hong

    2005-01-01

    The properties of anti-seismic HRB400 steel bars with 25 mm diameter were systematically investigated. The results showed that the properties of the HRB400 reinforced steel bars had been greatly enhanced comparing with HRB335 steel bars, i.e. coordination of strength and ductility, strain-aging sensibility, low temperature impact toughness, weld ability and high strain low cycle fatigue. The ductile-brittle transit temperatures of hot-rolled and strain-aged steel bars were evaluated as -17℃ and-8℃ respectively, and the low temperature impact toughness of HRB400 steel bars remains to be improved. Transmission electron microscopy (TEM) and electron diffraction showed little vanadium existed in ferrite as VN, most of which existed in pearlite as alloy cementite which resulted in the declination of impact toughness. Methods were suggested to improve the anti-seismic properties of steel bars.

  15. Shepherding Tidal Debris with the Galactic Bar: The Ophiuchus Stream

    CERN Document Server

    Hattori, Kohei; Sanders, Jason L

    2015-01-01

    The dynamics of stellar streams in rotating barred potentials is explained for the first time. Naturally, neighbouring stream stars reach pericentre at slightly different times. In the presence of a rotating bar, these neighbouring stream stars experience different bar orientations during pericentric passage and hence each star receives a different torque from the bar. These differing torques reshape the angular momentum and energy distribution of stars in the stream, which in turn changes the growth rate of the stream. For a progenitor orbiting in the same sense as the bar's rotation and satisfying a resonance condition, the resultant stream can be substantially shorter or longer than expected, depending on whether the pericentric passages of the progenitor occur along the bar's minor or major axis respectively. We present a full discussion of this phenomenon focusing mainly on streams confined to the Galactic plane. In stark contrast with the evolution in static potentials, which give rise to streams that g...

  16. Uncertainties in the Deprojection of the Observed Bar Properties

    CERN Document Server

    Zou, Yanfei; Li, Zhao-Yu

    2014-01-01

    In observations, it is important to deproject the two fundamental quantities characterizing a bar, i.e., its length ($a$) and ellipticity ($e$), to face-on values before any careful analyses. However, systematic estimation on the uncertainties of the commonly used deprojection methods is still lacking. Simulated galaxies are well suited in this study. We project two simulated barred galaxies onto a 2D plane with different bar orientations and disk inclination angles ($i$). Bar properties are measured and deprojected with the popular deprojection methods in the literature. Generally speaking, deprojection uncertainties increase with increasing $i$. All the deprojection methods behave badly when $i$ is larger than $60^\\circ$, due to vertical thickness of the bar. Thus, future statistical studies of barred galaxies should exclude galaxies more inclined than $60^\\circ$. At moderate inclination angles ($i\\leq60^\\circ$), 2D deprojection methods (analytical and image stretching) and Fourier-based methods (Fourier de...

  17. The application of bar coding technology at WIPP

    International Nuclear Information System (INIS)

    Bar coding at the Waste Isolation Pilot Plant (WIPP) can be used to track waste containers within the facility, control transuranic (TRU) waste inventory flow, and reduce manpower and error in recording package identification or control parameters. By choosing where and when to bar code, precise timelines or time-and-motion studies can be conducted to aid in streamlining waste handling throughput at WIPP. Additionally, the use of bar codes as waste container identification (ID) numbers increases the accuracy of recording the ID numbers by four orders of magnitude. The bar code label can also be utilized for other functions, such as shipping labels. Also, the bar code is integrated with the waste management data base such that the entire data base can be accessed on a computer using a bar code

  18. A unifying mechanism accounts for sensing of membrane curvature by BAR domains, amphipathic helices and membrane-anchored proteins

    DEFF Research Database (Denmark)

    Bhatia, Vikram Kjøller; Hatzakis, Nikos; Stamou, Dimitrios

    2010-01-01

    itself. We thus anticipate that membrane curvature will promote the redistribution of proteins that are anchored in membranes through any type of hydrophobic moiety, a thesis that broadens tremendously the implications of membrane curvature for protein sorting, trafficking and signaling in cell biology.......The discovery of proteins that recognize membrane curvature created a paradigm shift by suggesting that membrane shape may act as a cue for protein localization that is independent of lipid or protein composition. Here we review recent data on membrane curvature sensing by three structurally...... unrelated motifs: BAR domains, amphipathic helices and membrane-anchored proteins. We discuss the conclusion that the curvature of the BAR dimer is not responsible for sensing and that the sensing properties of all three motifs can be rationalized by the physicochemical properties of the curved membrane...

  19. Lipid-dependent effects of halothane on gramicidin channel kinetics: A new role for lipid packing stress

    OpenAIRE

    Weinrich, Michael; Rostovtseva, Tatiana K.; Bezrukov, Sergey M.

    2009-01-01

    We find that the sensitivity of gramicidin A channels to the anesthetic halothane is highly lipid dependent. Specifically, exposure of membranes made of lamellar DOPC to halothane in concentrations close to clinically relevant reduces channel life-times by an order of magnitude. At the same time, gramicidin channels in membranes of non-lamellar DOPE are little, if at all, affected by halothane. We attribute this difference in channel behavior to a difference in the stress of lipid packing int...

  20. Λ bar Λ production in two-photon interactions

    International Nuclear Information System (INIS)

    Using the CLEO detector at the Cornell e+e- storage ring CESR we study the two-photon production of Λ bar Λ, making the first observation of γγ→Λ bar Λ. We present the cross section for γγ→Λ bar Λ as a function of the γγ center of mass energy and compare it to that predicted by the quark-diquark model. copyright 1997 The American Physical Society

  1. Fault bars and the risk of feather damage in cranes

    OpenAIRE

    Jovani, Roger; Blas, Julio; Stoffel, M.J.; Bortolotti, L.E.; Bortolotti, Gary R.

    2010-01-01

    Fault bars are translucent areas across feathers grown under stressful conditions. They are ubiquitous across avian species and feather tracts. Because fault bars weaken feather structure and can lead to feather breakage, they may reduce flight performance and lower fitness. Therefore, natural selection might prime mechan- isms aimed at reducing the cost of fault bars, penalizing their occurrence in those feathers more relevant for flight. Here, we tested one prediction of this ‘fault...

  2. Kolkata Restaurant Problem as a Generalised El Farol Bar Problem

    Science.gov (United States)

    Chakrabarti, Bikas K.

    Generalisation of the El Farol bar problem to that of many bars here leads to the Kolkata restaurant problem, where the decision to go to any restaurant or not is much simpler (depending on the previous experience of course, as in the El Farol bar problem). This generalised problem can be exactly analysed in some limiting cases discussed here. The fluctuation in the restaurant service can be shown to have precisely an inverse cubic behavior, as widely seen in the stock market fluctuations.

  3. The structure of the Milky Way's bar outside the bulge

    Science.gov (United States)

    Wegg, Christopher; Gerhard, Ortwin; Portail, Matthieu

    2015-07-01

    While it is incontrovertible that the inner Galaxy contains a bar, its structure near the Galactic plane has remained uncertain, where extinction from intervening dust is greatest. We investigate here the Galactic bar outside the bulge, the long bar, using red clump giant (RCG) stars from United Kingdom Infrared Deep Sky Survey, Two Micron All Sky Survey, Vista Variables in the Via Lactea and Galactic Legacy Infrared Midplane Survey Extraordinaire. We match and combine these surveys to investigate a wide area in latitude and longitude, |b| ≤ 9° and |l| ≤ 40°. We find (i) the bar extends to l ˜ 25° at |b| ˜ 5° from the Galactic plane, and to l ˜ 30° at lower latitudes; (ii) the long bar has an angle to the line-of-sight in the range (28°-33°), consistent with studies of the bulge at |l| thin bar component reminiscent of the old thin disc near the Sun, and a ˜45 pc superthin bar components which exist predominantly towards the bar end; (v) constructing parametric models for the red clump magnitude distributions, we find a bar half-length of 5.0 ± 0.2 kpc for the two-component bar, and 4.6 ± 0.3 kpc for the thin bar component alone. We conclude that the Milky Way contains a central box/peanut bulge which is the vertical extension of a longer, flatter bar, similar as seen in both external galaxies and N-body models.

  4. Washing with contaminated bar soap is unlikely to transfer bacteria.

    OpenAIRE

    Heinze, J. E.; Yackovich, F.

    1988-01-01

    Recent reports of the isolation of microorganisms from used soap bars have raised the concern that bacteria may be transferred from contaminated soap bars during handwashing. Since only one study addressing this question has been published, we developed an additional procedure to test this concern. In our new method prewashed and softened commercial deodorant soap bars (0.8% triclocarban) not active against Gram-negative bacteria were inoculated with Escherichia coli and Pseudomonas aeruginos...

  5. Principles and Practices of Bar and Beverage Management

    OpenAIRE

    Murphy, James Peter

    2013-01-01

    Principles and Practices of Bar and Beverage Management is a comprehensive text and resource book designed to explain the latest developments and new complexities of managing modern bars - be they stand alone or part of larger institutions such as hotels and resorts. Consumer expectations have changed, and a bar today must deliver an integrated social experience in a safe modern environment, which also offers the latest products and services in a professional and engaging fashion. Against ...

  6. Dysregulated lipid metabolism in cancer

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Alteration of lipid metabolism has been increasingly recognized as a hallmark of cancer cells. The changes of expression and activity of lipid metabolizing enzymes are directly regulated by the activity of oncogenic signals. The dependence of tumor cells on the dysregulated lipid metabolism suggests that proteins involved in this process are excellent chemotherapeutic targets for cancer treatment. There are currently several drugs under development or in clinical trials that are based on specifically targeting the altered lipid metabolic pathways in cancer cells. Further understanding of dysregulated lipid metabolism and its associated signaling pathways will help us to better design efficient cancer therapeutic strategy.

  7. DWPF Melter No.2 Prototype Bus Bar Test Report

    International Nuclear Information System (INIS)

    Characterization and performance testing of a prototype DWPF Melter No.2 Dome Heater Bus Bar are described. The prototype bus bar was designed to address the design features of the existing system which may have contributed to water leaks on Melter No.1. Performance testing of the prototype revealed significant improvement over the existing design in reduction of both bus bar and heater connection maximum temperature, while characterization revealed a few minor design and manufacturing flaws in the bar. The prototype is recommended as an improvement over the existing design. Recommendations are also made in the area of quality control to ensure that critical design requirements are met

  8. CP violation and B0-(B0)-bar mixing

    International Nuclear Information System (INIS)

    The status of CP violation and B0-(B0)-bar mixing is given and the subsequent constraints in the framework of the Standard Model are discussed. Recent result on CP violation in the kaon system and related topics are reviewed, including the status of T violation and the tests of the CPT symmetry. The results on B0-(B0)-bar mixing are presented followed by the studies on Bd0-(Bd0)-bar and Bs0-(Bs0)-bar oscillations. Finally, the prospects of progress on understanding CP violation are discussed in framework of the new projects expected to produce results at the turn of the century. (author)

  9. Strain analysis of nonlocal viscoelastic Kelvin bar in tension

    Institute of Scientific and Technical Information of China (English)

    ZHAO Xue-chuan; LEI Yong-jun; ZHOU Jian-ping

    2008-01-01

    Based on viscoelastic Kelvin model and nonlocal relationship of strain and stress, a nonlocal constitutive relationship of viscoelasticity is obtained and the strain response of a bar in tension is studied. By transforming governing equation of the strain analysis into Volterra integration form and by choosing a symmetric exponential form of kernel function and adapting Neumann series, the closed-form solution of strain field of the bar is obtained. The creep process of the bar is presented. When time approaches infinite, the strain of bar is equal to the one of nonlocal elasticity.

  10. Shanghai’s Bars:Urban Romance and Sadness

    Institute of Scientific and Technical Information of China (English)

    LiuSha

    2002-01-01

    When speaking of Shanghai’s bars, what comes to people’s minds first must be Hengshan Street, a road known for its variety of bars. For many people, Hengshan Street is a landmark. On this street, bars in bold and unrestrained styles appeal to visitors. In fact, the whole street is a large open bar: the hurly-burly of "Hello" permeates every corner of the street; the resonant singing of "Rainbow Potato" echoes in the night sky; the rock’n roll of "Full House" fascinates passers-by with the wildness of John Lennon; even

  11. Stability of cassava flour-based food bars

    Directory of Open Access Journals (Sweden)

    Erica Caroline da Silva

    2013-03-01

    Full Text Available The consumption of Brazilian cassava has been reduced due to a lack of adjustment to the modern lifestyle. To reverse this trend, new products could be developed specifically targeted to high-value niche markets. Cereal bars stand out as fast food high in nutritional value. A bar formula mimicking cereal bars was prepared using a mixture of Brazilian cassava flour, hydrogenated vegetable fat, dried bananas, ground cashew nuts, and glucose syrup. After being pressed, the bars were dried for 1 hour at 65 °C, packaged in films, and stored under ambient conditions. Its stability was continuously monitored for 210 days in order to ensure its safety and enable its introduction to the market. Texture loss was observed in the packed bars after 90 days of storage, but the sensory characteristics allowed the testers to perceive this tendency after only 30 days of storage. However, chemical, physical, and microbial analyses confirmed that the bars were safe for consumption for 180 days. The results showed that a 45 g cassava flour-based bar enriched with nuts and dried fruits can meet 6% of the recommended daily fiber intake with a caloric value between that of the common cereal bar and that of an energy bar. Adapting the formula with ingredients (fruits, nuts from different regions of Brazil may add value to this traditional product as a fast food.

  12. Cosmic evolution of bars in simulations of galaxy formation

    CERN Document Server

    Okamoto, Takashi; Habe, Asao

    2014-01-01

    We investigate the evolution of two bars formed in fully self-consistent hydrodynamical simulations of the formation of Milky Way-mass galaxies. One galaxy shows higher central mass concentration and has a longer and stronger bar than the other at $z = 0$. The stronger bar evolves by transferring its angular momentum mainly to the dark halo. Consequently the rotation speed of the bar decreases with time, while the amplitude of the bar increases with time. While these features qualitatively agree with the results obtained by idealized simulations, our bars show some unusual behaviors. The pattern speed of the stronger bar largely goes up and down within a half revolution in its early evolutionary stage. This unsteady rotation occurs when the bar is misaligned with the $m = 4$ mode Fourier component. The amplitude of the weaker bar does not increase despite the fact that its rotation slows down with time. This result contradicts what is expected from idealized simulations and is caused by the decline of the cen...

  13. Lipid sorting revealed by SANS

    International Nuclear Information System (INIS)

    We have investigated the lipid sorting in a binary small unilamellar vesicle (SUV) composed of cone-shaped (1,2-dihexanoyl-sn-glycero-3-phosphocholine: DHPC) and cylinder-shaped (1,2-dipalmitoyl-sn-glycero-3-phosphocholine: DPPC) lipids. In order to reveal the lipid sorting we adopted a contrast matching technique of small angle neutron scattering (SANS), which extracts the distribution of deuterated lipids in the bilayer quantitatively. The SANS profile of deuterated SUVs at the contrast matching condition showed a characteristic scattering profile, indicating an asymmetric distribution of cone-shaped lipids in the bilayer. The fitting of the observed SANS profile revealed that most DHPC molecules are localized in the outer leaflet, which supports that the shape of the lipid is strongly coupled with the membrane curvature. We compared the obtained asymmetric distribution of the cone-shaped lipids in the bilayer with the theoretical prediction based on the curvature energy model. (author)

  14. Measurement of the B-bar 0 to D^* l ^- nu-bar Branching Fraction with a Partial Reconstruction Technique

    Energy Technology Data Exchange (ETDEWEB)

    Sonnek, Peter; /Mississippi U.

    2009-12-17

    Presented is a precise measurement of the {bar B}{sup 0} {yields} D*{sup +}{ell}{sup -}{bar {nu}}{sub {ell}} branching fraction using 81.47 fb{sup -1} of data collected with the BABAR detector at the PEP-II e{sup +}e{sup -} storage ring at the Stanford Linear Accelerator Center. The measurement was performed by partially reconstructing the D*{sup +} meson from {bar B}{sup 0} {yields} D*{sup +}{ell}{sup -}{bar {nu}}{sub {ell}} decays using only the soft pion of the D*{sup +} {yields} D{sup 0}{pi}{sup +} decay to reconstruct its four vector. The branching fraction was measured to be {Beta}({bar B}{sup 0} {yields} D*{sup +}{ell}{sup -}{bar {nu}}{sub {ell}}) = (4.91 {+-} 0.01{sub stat} {+-} 0.15{sub syst})%.

  15. Kondo effect of $\\bar{D}_{s}$ and $\\bar{D}_{s}^{\\ast}$ mesons in nuclear matter

    CERN Document Server

    Yasui, Shigehiro

    2016-01-01

    We study the Kondo effect for $\\bar{D}_{s}$ and $\\bar{D}_{s}^{\\ast}$ mesons as impurity particles in nuclear matter. The spin-exchange interaction between the $\\bar{D}_{s}$ or $\\bar{D}_{s}^{\\ast}$ meson and the nucleon induces the enhancement of the effective coupling in the low-energy scattering in the infrared region, whose scale of singularity is given by the Kondo scale. We investigate the Kondo scale in the renormalization group equation at nucleon one-loop level. We furthermore study the ground state with the Kondo effect in the mean-field approach, and present that the Kondo scale is related to the mixing strength between the $\\bar{D}_{s}$ or $\\bar{D}_{s}^{\\ast}$ meson and the nucleon in nuclear matter. We show the spectral function of the impurity when the Kondo effect occurs.

  16. Topological regulation of lipid balance in cells.

    Science.gov (United States)

    Drin, Guillaume

    2014-01-01

    Lipids are unevenly distributed within and between cell membranes, thus defining organelle identity. Such distribution relies on local metabolic branches and mechanisms that move lipids. These processes are regulated by feedback mechanisms that decipher topographical information in organelle membranes and then regulate lipid levels or flows. In the endoplasmic reticulum, the major lipid source, transcriptional regulators and enzymes sense changes in membrane features to modulate lipid production. At the Golgi apparatus, lipid-synthesizing, lipid-flippase, and lipid-transport proteins (LTPs) collaborate to control lipid balance and distribution within the membrane to guarantee remodeling processes crucial for vesicular trafficking. Open questions exist regarding LTPs, which are thought to be lipid sensors that regulate lipid synthesis or carriers that transfer lipids between organelles across long distances or in contact sites. A novel model is that LTPs, by exchanging two different lipids, exploit one lipid gradient between two distinct membranes to build a second lipid gradient. PMID:24606148

  17. Study of J/psi -> p(p)over-bar and J/psi -> n(n)over-bar

    NARCIS (Netherlands)

    Ablikim, M.; Achasov, M. N.; Ambrose, D. J.; An, F. F.; An, Q.; An, Z. H.; Bai, J. Z.; Ban, Y.; Becker, J.; Berger, N.; Bertani, M.; Bian, J. M.; Boger, E.; Bondarenko, O.; Boyko, I.; Briere, R. A.; Bytev, V.; Cai, X.; Calcaterra, A.; Cao, G. F.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, S. J.; Chen, Y.; Chen, Y. B.; Cheng, H. P.; Chu, Y. P.; Cronin-Hennessy, D.; Dai, H. L.; Dai, J. P.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; Ding, W. M.; Ding, Y.; Dong, L. Y.; Dong, M. Y.; Du, S. X.; Fang, J.; Fang, S. S.; Fava, L.; Feldbauer, F.; Feng, C. Q.; Ferroli, R. B.; Fu, C. D.; Fu, J. L.; Gao, Y.; Geng, C.; Goetzen, K.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A. Q.; Guo, L. B.; Guo, Y. P.; Han, Y. L.; Hao, X. Q.; Harris, F. A.; He, K. L.; He, M.; He, Z. Y.; Held, T.; Heng, Y. K.; Hou, Z. L.; Hu, H. M.; Hu, J. F.; Hu, T.; Huang, B.; Huang, G. M.; Huang, J. S.; Huang, X. T.; Huang, Y. P.; Hussain, T.; Ji, C. S.; Ji, Q.; Ji, X. B.; Ji, X. L.; Jia, L. K.; Jiang, L. L.; Jiang, X. S.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Jing, F. F.; Kalantar-Nayestanaki, N.; Kavatsyuk, M.; Kuehn, W.; Lai, W.; Lange, J. S.; Leung, J. K. C.; Li, C. H.; Li, Cheng; Li, Cui; Li, D. M.; Li, F.; Li, G.; Li, H. B.; Li, J. C.; Li, K.; Li, Lei; Li, N. B.; Li, Q. J.; Li, S. L.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, X. R.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Liao, X. T.; Liu, B. J.; Liu, B. J.; Liu, C. L.; Liu, C. X.; Liu, C. Y.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H.; Liu, H. B.; Liu, H. H.; Liu, H. M.; Liu, H. W.; Liu, J. P.; Liu, K. Y.; Liu, Kai; Liu, Kun; Liu, P. L.; Liu, S. B.; Liu, X.; Liu, X. H.; Liu, Y.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqiang; Liu, Zhiqing; Loehner, H.; Lu, G. R.; Lu, H. J.; Lu, J. G.; Lu, Q. W.; Lu, X. R.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lv, M.; Ma, C. L.; Ma, F. C.; Ma, H. L.; Ma, Q. M.; Ma, S.; Ma, T.; Ma, X. Y.; Ma, Y.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, H.; Mao, Y. J.; Mao, Z. P.; Messchendorp, J. G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Morales, C. Morales; Motzko, C.; Muchnoi, N. Yu.; Nefedov, Y.; Nicholson, C.; Nikolaev, I. B.; Ning, Z.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Park, J. W.; Pelizaeus, M.; Peters, K.; Ping, J. L.; Ping, R. G.; Poling, R.; Prencipe, E.; Pun, C. S. J.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, X. S.; Qin, Y.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Rong, G.; Ruan, X. D.; Sarantsev, A.; Schulze, J.; Shao, M.; Shen, C. P.; Shen, X. Y.; Sheng, H. Y.; Shepherd, M. R.; Song, X. Y.; Spataro, S.; Spruck, B.; Sun, D. H.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, X. D.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Thorndike, E. H.; Tian, H. L.; Toth, D.; Ullrich, M.; Varner, G. S.; Wang, B.; Wang, B. Q.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, Q.; Wang, Q. J.; Wang, S. G.; Wang, X. F.; Wang, X. L.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. Y.; Wei, D. H.; Weidenkaff, P.; Wen, Q. G.; Wen, S. P.; Werner, M.; Wiedner, U.; Wu, L. H.; Wu, N.; Wu, S. X.; Wu, W.; Wu, Z.; Xia, L. G.; Xiao, Z. J.; Xie, Y. G.; Xiu, Q. L.; Xu, G. F.; Xu, G. M.; Xu, H.; Xu, Q. J.; Xu, X. P.; Xu, Y.; Xu, Z. R.; Xue, F.; Xue, Z.; Yan, L.; Yan, W. B.; Yan, Y. H.; Yang, H. X.; Yang, T.; Yang, Y.; Yang, Y. X.; Ye, H.; Ye, M.; Ye, M. H.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yu, S. P.; Yuan, C. Z.; Yuan, W. L.; Yuan, Y.; Zafar, A. A.; Zallo, A.; Zeng, Y.; Zhang, B. X.; Zhang, B. Y.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J.; Zhang, J. G.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, L.; Zhang, S. H.; Zhang, T. R.; Zhang, X. J.; Zhang, X. Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Y. S.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, H. S.; Zhao, J. W.; Zhao, K. X.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, S. J.; Zhao, T. C.; Zhao, X. H.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, Y. H.; Zheng, Z. P.; Zhong, B.; Zhong, J.; Zhou, L.; Zhou, X. K.; Zhou, X. R.; Zhu, C.; Zhu, K.; Zhu, K. J.; Zhu, S. H.; Zhu, X. L.; Zhu, X. W.; Zhu, Y. M.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zou, B. S.; Zou, J. H.; Zuo, J. X.

    2012-01-01

    The decays J/psi -> p (p) over bar and J/psi -> n (n) over bar have been investigated with a sample of 225.2 x 10(6) J/psi events collected with the BESIII detector at the BEPCII e(+)e(-) collider. The branching fractions are determined to be B(J/psi -> p (p) over bar) = (2.112 +/- 0.004 +/- 0.031 x

  18. CP violation in hyperon decays: the case p-bar p → Λ-bar Λ → p-bar π+ pπ-

    International Nuclear Information System (INIS)

    An account is given of the experimental status of CP violation and of the phenomenology of hyperon non-leptonic decays. Updated information on the estimate of CP-violating observable in these decays is presented. An experimental programme is outlined, which aims to pursue the search for direct CP violation in hyperon-antihyperon decays by means of the reaction p-bar p → Λ-bar Λ → p-bar π+ pπ-. The experiment as well as analysis methods are described. Alternative approaches employing hyperons are also discussed. 54 refs., 1 tab., 13 figs

  19. Investigation of the $X(5568)$ as a fully open-flavor $su\\bar b\\bar d$ tetraquark state

    CERN Document Server

    Chen, Wei; Liu, Xiang; Steele, T G; Zhu, Shi-Lin

    2016-01-01

    We investigate the newly observed charged $X(5568)$ meson as an exotic open-flavor tetraquark state $su\\bar b\\bar d$ with $J^P=0^+/1^+$ in the framework of QCD sum rules. We use the color antisymmetric $[\\mathbf{\\bar 3_c}]_{su} \\otimes [\\mathbf{3_c}]_{\\bar{b}\\bar d}$ tetraquark currents in both scalar and axial-vector channels to perform evaluations and numerical analyses. Our results imply that the $X(5568)$ can be interpreted as both the scalar $su\\bar b\\bar d$ tetraquark state and the axial-vector one, which are in good agreement with the experiment observation. We also investigate the possible decay patterns of the $X(5568)$ and suggest to search for its neutral partner in the radiative decay into $B_s^0 \\gamma$ and $B_s^* \\gamma$, which can be used to determine its spin-parity quantum numbers. Moreover, we predict its charmed partner state around $2.55$ GeV with the quark content $su\\bar c\\bar d$ and $J^P=0^+/1^+$.

  20. $\\chi^{\\vphantom\\dagger}_{c0}(3915)$ As the Lightest $c\\bar c s \\bar s$ State

    OpenAIRE

    Lebed, Richard F.; Polosa, Antonio D.

    2016-01-01

    The state $\\chi^{\\vphantom\\dagger}_{c0}(3915)$ has recently been demoted by the Particle Data Group from its previous status as the conventional $c\\bar c$ $2 {}^3P_0$ state, largely due to the absence of expected $D\\bar D$ decays. We propose that $\\chi^{\\vphantom\\dagger}_{c0}(3915)$ is actually the lightest $c\\bar c s \\bar s$ state, and calculate the spectrum of such states using the diquark model, identifying many of the observed charmoniumlike states that lack open-charm decay modes as $c\\b...

  1. Examination of the Effects of a Sphingolipid-Enriched Lipid Fraction from Wheat Gluten on the Incidence of Diabetes in BBdp Rats

    OpenAIRE

    Shi, Wenjuan

    2004-01-01

    This study was designed to examine if a sphingolipid-enriched lipid fraction from wheat gluten could affect the incidence of type I diabetes in BioBreeding diabetes prone (BBdp) rats. Wheat gluten was extracted with a chloroform-methanol (CM) mixture to isolate most of the lipids. Isolated lipids were subjected to silica gel column chromatography and saponification to remove most of neutral lipids and phospholipids, leaving behind a lipid fraction enriched in sphingolipids. This sphingolipid-...

  2. /bar p/p collider physics

    Energy Technology Data Exchange (ETDEWEB)

    Green, D.

    1989-03-01

    This note encompasses a set of six lectures given at the summer school held at Campos Do Jordao in January of 1989 near Sao Paulo, Brazil. The intent of the lectures was to describe the physics of /bar p/p at CERN and Fermilab. Particular attention has been paid to making a self contained presentation to a prospective audience of graduate students. Since large Monte Carlo codes might not be available to all members of this audience, great reliance was placed on ''back of the envelope estimates.'' Emphasis was also placed on experimental data rather than theoretical speculation, since predictions for, for example, supersymmetric particle production are easily obtained by transcription of formulae already obtained. 9 refs., 67 figs., 2 tabs.

  3. Bars and spheroids in gravimetry problem

    CERN Document Server

    Sizikov, Valery

    2016-01-01

    The direct gravimetry problem is solved by dividing each deposit body into a set of vertical adjoining bars, whereas in the inverse problem, each deposit body is modelled by a homogeneous ellipsoid of revolution (spheroid). Well-known formulae for the z-component of gravitational intensity for a spheroid are transformed to a convenient form. Parameters of a spheroid are determined by minimizing the Tikhonov smoothing functional with constraints on the parameters, which makes the ill-posed inverse problem by unique and stable. The Bulakh algorithm for initial estimating the depth and mass of a deposit is modified. The proposed technique is illustrated by numerical model examples of deposits in the form of two and five bodies. The inverse gravimetry problem is interpreted as a gravitational tomography problem or, in other words, as "introscopy" of Earth's crust and mantle.

  4. A Distinct Structure inside the Galactic Bar

    Science.gov (United States)

    Nishiyama, Shogo; Nagata, Tetsuya; Baba, Daisuke; Haba, Yasuaki; Kadowaki, Ryota; Kato, Daisuke; Kurita, Mikio; Nagashima, Chie; Nagayama, Takahiro; Murai, Yuka; Nakajima, Yasushi; Tamura, Motohide; Nakaya, Hidehiko; Sugitani, Koji; Naoi, Takahiro; Matsunaga, Noriyuki; Tanabé, Toshihiko; Kusakabe, Nobuhiko; Sato, Shuji

    2005-03-01

    We present the result of a near-infrared (JHKs) survey along the Galactic plane, -10.5dSIRIUS camera. Ks versus H-Ks color-magnitude diagrams reveal a well-defined population of red clump stars whose apparent magnitude peak changes continuously along the Galactic plane, from Ks=13.4 at l=-10deg to Ks=12.2 at l=10deg after dereddening. This variation can be explained by the barlike structure found in previous studies, but we find an additional inner structure at |l|<~4deg, where the longitude-apparent magnitude relation is distinct from the outer bar and where the apparent magnitude peak changes by only ~0.1 mag over the central 8°. The exact nature of this inner structure is as yet uncertain.

  5. Bus bar electrical feedthrough for electrorefiner system

    Science.gov (United States)

    Williamson, Mark; Wiedmeyer, Stanley G; Willit, James L; Barnes, Laurel A; Blaskovitz, Robert J

    2013-12-03

    A bus bar electrical feedthrough for an electrorefiner system may include a retaining plate, electrical isolator, and/or contact block. The retaining plate may include a central opening. The electrical isolator may include a top portion, a base portion, and a slot extending through the top and base portions. The top portion of the electrical isolator may be configured to extend through the central opening of the retaining plate. The contact block may include an upper section, a lower section, and a ridge separating the upper and lower sections. The upper section of the contact block may be configured to extend through the slot of the electrical isolator and the central opening of the retaining plate. Accordingly, relatively high electrical currents may be transferred into a glovebox or hot-cell facility at a relatively low cost and higher amperage capacity without sacrificing atmosphere integrity.

  6. A high luminosity bar BB factory

    International Nuclear Information System (INIS)

    In this paper the authors discuss a proposal for the construction of a high luminosity, L ∼ 1034 cm-2 s-1, electron-positron collider, operating in the energy range of 10 to 15 GeV total center of mass energy. The motivation for such a bar B-B system, in particular the rare decay modes and the CP violation. In this paper the authors give only a preliminary estimate of the main parameters of this system, with the purpose of establishing its feasibility. The high luminosity required to study the B physics makes any collider extremely difficult, and pushes the beam characteristics to a region not yet explored. What we propose is no exception and will require a large amount of research and development of beam physics and technology before a more detailed proposal can be made

  7. Dietary fructose and glucose differentially affect lipid and glucose homeostasis

    Science.gov (United States)

    Absorbed glucose and fructose differ in that glucose largely escapes first pass removal by the liver, whereas fructose does not, resulting in different metabolic effects of these two monosaccharides. In short-term controlled feeding studies, dietary fructose significantly increases postprandial trig...

  8. INFLUENCING OF FRICTION IN HINGES FORCE SIZE OF BARS

    Directory of Open Access Journals (Sweden)

    BOHOMAZ V. N.

    2016-04-01

    Full Text Available Formulation of the problem. The size of critical force of bar on the traditional method of calculation is determined in supposition of ideal hinge in the place of fixing of bar. There are both a hinge resistance at the turn of bar ends and their moving in the real hinges. Thus, there is the necessity of influencing character determination of these hinge imperfections on the size of critical force. In the existent scientific labours is devoted the alike problems, influencing of friction in the hinges of bar fastening on the size of critical force was not taken into account. At determination of bars stability with no ideality of hinges friction in them it is possible to take into account by the eccentric appendix of loading or appendix of moment. However at such approach it is difficult enough to define the size of attached force or moment. Purpose. To set influencing of friction in the hinge of bar fastening on of his critical force size in sense of Euler, and also build dependences for determination of bar critical force taking into account mechanical descriptions of hinges materials. Conclusion. For the task of determination the size of bar critical force with the joint fastening on ends are got the dependences which take into account mechanical descriptions of material hinge. The received dependences allow to define more exact meaning of critical force for bars. The examples of calculation of whole bar and bar with undercuting in the middle are resulted that values of critical force, certain on a traditional method are overpriced.

  9. Nutritional Evaluation of NASA's Rodent Food Bar Diet

    Science.gov (United States)

    Barrett, Joyce E.; Yu, Diane S.; Dalton, Bonnie P.

    2000-01-01

    Tests are being conducted on NASA's rodent Food Bar in preparation for long-term use as the rat and mouse diet aboard the International Space Station. Nutritional analyses are performed after the bars are manufactured and then repeated periodically to determine nutritional stability. The primary factors analyzed are protein, ash, fat, fiber, moisture, amino acids, fatty acids, and minerals. Nutrient levels are compared to values published in the National Research Council's dietary requirements for rodents, and also to those contained in several commonly used commercial rodent lab diets. The Food Bar is manufactured from a powdered diet to which moisture is added as it is processed through an extruder. The bars are dipped into potassium sorbate, vacuum-sealed, and irradiated. In order to determine nutrient changes during extrusion and irradiation, the powdered diet, the non-irradiated bars, and the irradiated bars are all analyzed. We have observed lower values for some nutrients (iodine, vitamin K, and iron) in the Food Bars compared with NRC requirements. Many nutrients in the Food Bars are contained at a higher level than levels in the NRC requirements. An additional factor we are investigating is the 26% moisture level in the Food Bars, which drops to about 15% within a week, compared to a stable 10% moisture in many standard lab chow diets. In addition to the nutritional analyses, the food bar is being fed to several strains of rats and mice, and feeding study and necropsy results are being observed (Barrett et al, unpublished data). Information from the nutritional analyses and from the rodent studies will enable us to recommend the formulation that will most adequately meet the rodent Food Bar requirements for long-term use aboard the Space Station.

  10. Dietary Lipid and Carbohydrate Interactions: Implications on Lipid and Glucose Absorption, Transport in Gilthead Sea Bream (Sparus aurata) Juveniles.

    Science.gov (United States)

    Castro, Carolina; Corraze, Geneviève; Basto, Ana; Larroquet, Laurence; Panserat, Stéphane; Oliva-Teles, Aires

    2016-06-01

    A digestibility trial was performed with gilthead sea bream juveniles (IBW = 72 g) fed four diets differing in lipid source (fish oil, FO; or a blend of vegetable oil, VO) and starch content (0 %, CH-; or 20 %, CH+) to evaluate the potential interactive effects between carbohydrates and VO on the processes involved in digestion, absorption and transport of lipids and glucose. In fish fed VO diets a decrease in lipid digestibility and in cholesterol (C), High Density Lipoprotein(HDL)-C and Low Density Lipoprotein (LDL)-C (only in CH+ group) were recorded. Contrarily, dietary starch induced postprandial hyperglycemia and time related alterations on serum triacylglycerol (TAG), phospholipid (PL) and C concentrations. Fish fed a CH+ diet presented lower serum TAG than CH- group at 6 h post-feeding, and the reverse was observed at 12 h post-feeding for TAG and PL. Lower serum C and PL at 6 h post-feeding were recorded only in VOCH+ group. No differences between groups were observed in hepatic and intestinal transcript levels of proteins involved in lipid transport and hydrolysis (FABP, DGAT, GPAT, MTP, LPL, LCAT). Lower transcript levels of proteins related to lipid transport (ApoB, ApoA1, FABP2) were observed in the intestine of fish fed the CH+ diet, but remained unchanged in the liver. Overall, transcriptional mechanisms involved in lipid transport and absorption were not linked to changes in lipid serum and digestibility. Dietary starch affected lipid absorption and transport, probably due to a delay in lipid absorption. This study suggests that a combination of dietary VO and starch may negatively affect cholesterol absorption and transport. PMID:27023202

  11. Predicting Vertical Jump Height from Bar Velocity

    Directory of Open Access Journals (Sweden)

    Amador García-Ramos, Igor Štirn, Paulino Padial, Javier Argüelles-Cienfuegos, Blanca De la Fuente, Vojko Strojnik, Belén Feriche

    2015-06-01

    Full Text Available The objective of the study was to assess the use of maximum (Vmax and final propulsive phase (FPV bar velocity to predict jump height in the weighted jump squat. FPV was defined as the velocity reached just before bar acceleration was lower than gravity (-9.81 m·s-2. Vertical jump height was calculated from the take-off velocity (Vtake-off provided by a force platform. Thirty swimmers belonging to the National Slovenian swimming team performed a jump squat incremental loading test, lifting 25%, 50%, 75% and 100% of body weight in a Smith machine. Jump performance was simultaneously monitored using an AMTI portable force platform and a linear velocity transducer attached to the barbell. Simple linear regression was used to estimate jump height from the Vmax and FPV recorded by the linear velocity transducer. Vmax (y = 16.577x - 16.384 was able to explain 93% of jump height variance with a standard error of the estimate of 1.47 cm. FPV (y = 12.828x - 6.504 was able to explain 91% of jump height variance with a standard error of the estimate of 1.66 cm. Despite that both variables resulted to be good predictors, heteroscedasticity in the differences between FPV and Vtake-off was observed (r2 = 0.307, while the differences between Vmax and Vtake-off were homogenously distributed (r2 = 0.071. These results suggest that Vmax is a valid tool for estimating vertical jump height in a loaded jump squat test performed in a Smith machine.

  12. INFLUENCE OF GENDER ON THE RELATIONSHIP BETWEEN INSULIN SENSITIVITY, ADIPOSITY AND PLASMA LIPIDS IN LEAN NON-DIABETIC SUBJECTS

    OpenAIRE

    Masharani, Umesh; Goldfine, Ira D; Youngren, Jack F.

    2009-01-01

    Individuals with obesity frequently have an atherogenic lipid profile. It has been proposed that the insulin resistance observed in these individuals is involved in the development of these lipid abnormalities. However, most studies that have examined the relationship between insulin resistance and lipid abnormalities have included subjects who are either obese and/or glucose intolerant, two factors that may affect lipid levels independent of insulin resistance. We have therefore examined the...

  13. Applying Schwarzschild's orbit superposition method to barred or non-barred disc galaxies

    CERN Document Server

    Vasiliev, Eugene

    2015-01-01

    We present an implementation of the Schwarzschild orbit superposition method which can be used for constructing self-consistent equilibrium models of barred or non-barred disc galaxies, or of elliptical galaxies with figure rotation. This is a further development of the publicly available code SMILE; its main improvements include a new efficient representation of an arbitrary gravitational potential using two-dimensional spline interpolation of Fourier coefficients in the meridional plane, as well as the ability to deal with rotation of the density profile and with multicomponent mass models. We compare several published methods for constructing composite axisymmetric disc--bulge--halo models and demonstrate that our code produces the models that are closest to equilibrium. We also apply it to create models of triaxial elliptical galaxies with cuspy density profiles and figure rotation, and find that such models can be found and are stable over many dynamical times in a wide range of pattern speeds and angula...

  14. Chiral perturbation theory for vertical bar ΔI vertical bar = (3(2)) hyperon decays

    International Nuclear Information System (INIS)

    We study the vertical bar ΔI vertical bar = (3(2)) amplitudes of hyperon non-leptonic decays of the form B → B'π in the context of chiral perturbation theory. The lowest-order predictions are determined in terms of only one unknown parameter and are consistent within errors with current data. We investigate the theoretical uncertainty of these predictions by calculating the leading non-analytic corrections. We also present an estimate for the size of the S-wave Λ and Ξ decays which vanish at leading order. We find that the corrections to the lowest-order predictions are within the expectations of naive power counting and, therefore, that this picture can be tested more accurately with improved measurements

  15. Study of the decays D0→K bar K, π bar π

    International Nuclear Information System (INIS)

    Using the CLEO detector we have observed the Cabibbo-suppressed decays D0→K0 bar K0, K+K-, and π+π-. We determine B(D0→K0 bar K0)= (0.13+0.07-0.05+0.02-0.02)%. Our measurement B(D0→K+K-)/B(D0→π+π-)=2.35±0.37±0.28 represents asubstantial improvement over previous results. We find no evidence for the decay D0→π0π0, and place a 90%-confidence-level upper limit of B(D0→π0π0)<0.46%

  16. Energy Drinks and Food Bars: Power or Hype?

    Science.gov (United States)

    ... How Can I Help a Friend Who Cuts? Energy Drinks and Food Bars: Power or Hype? KidsHealth > ... nutritivas: ¿Energía o mera exageración? The Buzz on Energy Foods Energy drinks and nutrition bars often make ...

  17. Dynamics of deeply bound (K) over-bar states

    Czech Academy of Sciences Publication Activity Database

    Mareš, Jiří; Friedman, E.; Gal, A.

    2007-01-01

    Roč. 22, 2-3 (2007), s. 633-636. ISSN 0217-751X R&D Projects: GA AV ČR IAA100480617 Institutional research plan: CEZ:AV0Z10480505 Keywords : over-bar-nuclear bound states * over-bar-nuclear relativistic mean field calculations Subject RIV: BE - Theoretical Physics Impact factor: 0.764, year: 2007

  18. Morphologies introduced by bistability in barred-spiral galactic potentials

    Science.gov (United States)

    Tsigaridi, L.; Patsis, P. A.

    2015-04-01

    We investigate the orbital dynamics of a barred-spiral model when the system is rotating slowly and corotation is located beyond the end of the spiral arms. In the characteristic of the central family of periodic orbits, we find a `bistable region'. In the response model, we observe a ring surrounding the bar and spiral arms starting tangential to the ring. This is a morphology resembling barred-spiral systems with inner rings. However, the dynamics associated with this structure in the case we study is different from that of a typical bar ending close to corotation. The ring of our model is round, or rather elongated perpendicular to the bar. It is associated with a folding (an `S'-shaped feature) of the characteristic of the central family, which is typical in bistable bifurcations. Along the `S' part of the characteristic, we have a change in the orientation of the periodic orbits from an x1-type to an x2-type morphology. The orbits populated in the response model change rather abruptly their orientation when reaching the lowest energy of the `S'. The spirals of the model follow a standard `precessing ellipses flow' and the orbits building them have energies beyond the `S' region. The bar is structured mainly by sticky orbits from regions around the stability islands of the central family. This leads to the appearance of X features in the bars on the galactic plane. Such a bar morphology appears in the unsharp-masked images of some moderately inclined galaxies.

  19. Mechanical Properties of Welded Deformed Reinforcing Steel Bars

    Directory of Open Access Journals (Sweden)

    Ghafur H. Ahmed

    2015-05-01

    Full Text Available Reinforcement strength, ductility and bendability properties are important components in design of reinforced concrete members, as the strength of any member comes mainly from reinforcement. Strain compatibility and plastic behaviors are mainly depending on reinforcement ductility. In construction practice, often welding of the bars is required. Welding of reinforcement is an instant solution in many cases, whereas welding is not a routine connection process. Welding will cause deficiencies in reinforcement bars, metallurgical changes and re-crystallization of microstructure of particles. Weld metal toughness is extremely sensitive to the welding heat input that decreases both of its strength and ductility. For determining the effects of welding in reinforcement properties, 48 specimens were tested with 5 different bar diameters, divided into six groups. Investigated parameters were: properties of un-welded bars; strength, ductility and density of weld metal; strength and ductility reduction due to heat input for bundled bars and transverse bars; welding effect on bars’ bending properties; behavior of different joint types; properties of three weld groove shapes also the locations and types of failures sections. Results show that, strength and elongation of the welded bars decreased by (10-40% and (30-60% respectively. Cold bending of welded bars and groove welds shall be prevented.

  20. Nutrition Education Strategies: A Trip to the Salad Bar.

    Science.gov (United States)

    Nutter, June; Kotch, Anne

    1995-01-01

    Learning activities related to visiting a salad bar can help students apply basic nutrition concepts to real-life situations and make healthier choices at restaurants and in food preparation. The paper describes a class activity involving students in setting up a salad bar, making choices among ingredients and dressings, and taking home leftovers.…

  1. Salt effects on lamellar repeat distance depending on head groups of neutrally charged lipids.

    Science.gov (United States)

    Hishida, Mafumi; Yamamura, Yasuhisa; Saito, Kazuya

    2014-09-01

    Change in lamellar repeat distances of neutrally charged lipids upon addition of monovalent salts was measured with small-angle X-ray scattering for combinations of two lipids (PC and PE lipids) and six salts. Large dependence on lipid head group is observed in addition to those on added cation and anion. The ion and lipid dependences have little correlation with measured surface potentials of lipid membranes. These results indicate that the lamellar swelling by salt is not explained through balance among interactions considered previously (van der Waals interaction, electrostatic repulsion emerged by ion binding, etc.). It is suggested that effect of water structure, which is affected by not only ions but also lipid itself, should be taken into account for understanding membrane-membrane interactions, as in the Hofmeister effect. PMID:25126900

  2. Thermoneutrality modifies the impact of hypoxia on lipid metabolism.

    Science.gov (United States)

    Jun, Jonathan C; Shin, Mi-Kyung; Yao, Qiaoling; Devera, Ronald; Fonti-Bevans, Shannon; Polotsky, Vsevolod Y

    2013-02-15

    Hypoxia has been shown to rapidly increase triglycerides in mice by decreasing plasma lipoprotein clearance. However, the usual temperature of hypoxic exposure is below thermoneutrality for mice, which may increase thermogenesis and energy requirements, resulting in higher tissue lipid uptake. We hypothesize that decreased lipid clearance and ensuing hyperlipidemia are caused by hypoxic suppression of metabolism at cold temperatures and, therefore, would not occur at thermoneutrality. Twelve-week-old, male C57BL6/J mice were exposed to 6 h of 10% O₂ at the usual temperature (22°C) or thermoneutrality (30°C). Acclimation to 22°C increased lipid uptake in the heart, lungs, and brown adipose tissue, resulting in lower plasma triglyceride and cholesterol levels. At this temperature, hypoxia attenuated lipid uptake in most tissues, thereby raising plasma triglycerides and LDL cholesterol. Thermoneutrality decreased tissue lipid uptake, and hypoxia did not cause a further reduction in lipid uptake in any organs. Consequently, hypoxia at thermoneutrality did not affect plasma triglyceride levels. Unexpectedly, plasma HDL cholesterol increased. The effect of hypoxia on white adipose tissue lipolysis was also modified by temperature. Independent of temperature, hypoxia increased heart rate and glucose and decreased activity, body temperature, and glucose sensitivity. Our study underscores the importance of ambient temperature for hypoxia research, especially in studies of lipid metabolism. PMID:23249698

  3. Lipid modulation of neuronal cholinergic activity

    International Nuclear Information System (INIS)

    Phospholipids are the major lipids in the plasma membrane, and it is now evident that the function of phospholipids exceeds that of the role of barrier between different aqueous compartments. Several lines of evidence suggest that a major plasma membrane lipids, phosphatidylcholine, may be a useful compound for modulating presynaptic cholinergic transmission. In order to investigate the effects of PC on cholinergic terminals, rat cortical synaptosomes were preloaded with [3H]-ACh and then treated with small unilamellar vesicles (SUV) composed of dipalmitoylphosphatidylcholine (DPPC) at concentrations (0.8-1.5 mg/ml) similar to those found circulating in plasma. The effects of DPPC on levels, hydrolysis, release, and synthesis of [3H]-ACh were then examined. Dipalmitoylphosphatidylcholine decreased the levels of [3H]-ACh. This decrease does not result from a dilution of the radioactive [3H]-choline by nonradioactive choline derived from PC. Specifically, it is the S3 (cytoplasmic) level of [3H]-ACh that is decreased by DPPC treatment. This decrease appears to be partially due to lipid activation of an intraterminal cholinesterase which results in hydrolysis of nonvesicular [3H]-ACh. The ability of the lipid to interfere with exocytosis may account for the blockade of the K+ induced [3H]-ACh release from the P3 (vesicular) fraction. The high affinity choline transporter was competitively inhibited by DPPC treatment when synaptosomes were treated with DPPC prior to [3H]-choline loading; the ubiquitous low affinity transport was not affected. These effects were specific for cholinergic neurons since the uptake and release of dopamine and norepinephrine from the substantia nigra and the cortex, respectively, were not affected

  4. Stellar population constraints on the ages of galactic bars

    CERN Document Server

    James, Phil A

    2016-01-01

    We present a study of the stellar populations within the central regions of four nearby barred galaxies, and use a novel technique to constrain the duration of bar activity. We focus on the star formation 'desert', a region within each of these galaxies where star formation appears to have been suppressed by the bar. New H beta spectroscopic data are presented, and used to produce spectroscopic line indices which are compared with theoretical predictions from population synthesis models for simple stellar populations and temporally truncated star formation histories. This analysis shows that the dearth of star formation activity in these regions appears to have been continuing for at least 1 Gyr, with timescales of several Gyr indicated for two of the galaxies. This favours models in which strong bars can be long-lived features of galaxies, but our results also indicate a significant diversity in stellar population ages, and hence in the implied histories of bar activity in these four galaxies.

  5. Spectral narrowing of a 980 nm tapered diode laser bar

    DEFF Research Database (Denmark)

    Vijayakumar, Deepak; Jensen, Ole Bjarlin; Lucas Leclin, Gaëlle;

    2011-01-01

    in wavelength specific applications and hence, it is vital to stabilize the emission spectrum of these devices. In our experiment, we describe the wavelength narrowing of a 12 element 980 nm tapered diode laser bar using a simple Littman configuration. The tapered laser bar which suffered from a big......High power diode laser bars are interesting in many applications such as solid state laser pumping, material processing, laser trapping, laser cooling and second harmonic generation. Often, the free running laser bars emit a broad spectrum of the order of several nanometres which limit their scope...... smile has been "smile corrected" using individual phase masks for each emitter. The external cavity consists of the laser bar, both fast and slow axis micro collimators, smile correcting phase mask, 6.5x beam expanding lens combination, a 1200 lines/mm reflecting grating with 85% efficiency in the first...

  6. Hydrodynamic and geomorphic controls on mouth bar evolution

    Science.gov (United States)

    Esposito, Christopher R.; Georgiou, Ioannis Y.; Kolker, Alexander S.

    2013-04-01

    While river deltas are one of the major repositories for sediments and carbon on Earth, there exists a paucity of field data on the formation of distributary mouth bars—one of their key features. Here we present results from an experiment that tested a model of mouth bar development using hydroacoustic, optical, sedimentary, and geochemical tools on a mouth bar in a crevasse splay near the mouth of the Mississippi River. Our results validate an existing model for mouth bar development, which we extend to explain mouth bar stratigraphy. We propose that changes across a hydrological cycle are important for mouth bar development, resulting in a stratigraphy that has alternating fine and coarse grain sediments. Results also indicate that sand is carried up to 6 km from the main stem of the Mississippi River, despite repeated channel bifurcations, which has important implications for our interpretation of the rock record, understanding of coastal sedimentary systems, and the restoration of large deltas.

  7. Bar code technology improves positive patient identification and transfusion safety.

    Science.gov (United States)

    Sandler, S G; Langeberg, A; Dohnalek, L

    2005-01-01

    As a result of human error, an estimated 1 in 12,000 blood transfusions is given to the wrong patient. The cause of nearly all of these errors is failure of hospital personnel to identify positively intended transfusion recipients, their blood samples for cross-matching, or their correct blood components. We describe our experience using a point-of-care bar code transfusion safety system that links patients' bar-coded wristbands, with bar-coded labels on blood sample tubes, blood component bags, and nurses' identification badges. The result was 100 % accuracy of matching patients, their blood samples, and components for transfusions. For verifying information before starting blood transfusions, nurses preferred bar code "double checks" to conventional visual "double checks" by a second nurse. Methods are needed to reinforce nurses' proficiency with technological approaches to transfusion safety, such as software-driven bar code scanning, in situations where transfusions are administered infrequently. PMID:16050151

  8. A Full Hydro- and Morphodynamic Description of Breaker Bar Development

    DEFF Research Database (Denmark)

    Jacobsen, Niels Gjøl

    net cross shore suspended sediment transport flux as a function of either of the variables $\\zeta_0$, $\\Omega$, or $\\Omega_{HK}$. Secondly, the bed is allowed to evolve under the influence of the sediment transport processes. The development of breaker bars in both laboratory scale settings and...... prototype scale settings is considered. The temporal development of the cross shore profile is simulated for several combinations of wave forcing and sediment grain diameters. The variation is described with emphasis on the development of the crest level of the breaker bar, the variation in the bed shear...... stress on the crest of the breaker bar, and its migration speed. Additionally, a net onshore current over a breaker bar is considered, where this current mimics the presence of a horizontal circulation cell. The development of the breaker bar is described for different values of the net onshore current...

  9. Characterizing Barred Galaxies in the Abell 901/902 Supercluster

    CERN Document Server

    Marinova, I; Bacon, D; Balogh, M; Barden, M; Barazza, F D; Bell, E F; Böhm, A; Caldwell, J A R; Gray, M E; Haussler, B; Heymans, C; Jahnke, K; Van Kampen, E; Koposov, S; Lane, K; McIntosh, D H; Meisenheimer, K; Peng, C Y; Rix, H -W; Sánchez, S F; Taylor, A; Wisotzki, L; Wolf, C; Zheng, X

    2008-01-01

    In dense clusters, higher densities at early epochs as well as physical processes, such as ram pressure stripping and tidal interactions become important, and can have direct consequences for the evolution of bars and their host disks. To study bars and disks as a function of environment, we are using the STAGES ACS HST survey of the Abell 901/902 supercluster (z~0.165), along with earlier field studies based the SDSS and the Ohio State University Bright Spiral Galaxy Survey (OSUBSGS). We explore the limitations of traditional methods for characterizing the bar fraction, and in particular highlight uncertainties in disk galaxy selection in cluster environments. We present an alternative approach for exploring the proportion of bars, and investigate the properties of bars as a function of host galaxy color, Sersic index, stellar mass, star formation rate (SFR), specific SFR, and morphology.

  10. Corrosion of reinforcement bars in steel ibre reinforced concrete structures

    DEFF Research Database (Denmark)

    Solgaard, Anders Ole Stubbe

    perpendicular to the reinforcement bar) was reduced for SFRC compared to plain concrete, whereas there was no clear impact on the slip at the concrete/steel-bar (displacement discontinuity parallel to the reinforcement bar) caused by the steel fibres. Additional experimental and numerical studies concerning......Steel fibres have been known as an alternative to traditional reinforcement bars for special applications of structural concrete for decades and the use of steel fibre reinforced concrete (SFRC) has gradually increased in recent years. Steel fibres lead to reduced crack widths in concrete formed......, among other reasons, due to shrinkage and/or mechanical loading. Steel fibres are nowadays also used in combination with traditional reinforcement for structural concrete, where the role of the fibres is to minimize the crack widths whereas the traditional reinforcement bars are used for structural...

  11. Near-infrared surface photometry of barred spiral galaxies

    International Nuclear Information System (INIS)

    On the basis of a number of theoretical studies, it must be concluded that bar-like stellar structures are a preferred dynamical form in the process of galaxy formation and evolution. The objective of the observational research reported in this paper is to study by surface photometry parameters which describe the radial and azimuthal luminosity distributions of the bars of barred spiral galaxies. Such information is important for a comparison with theoretical models. The observational data are discussed, taking into account the photographic material, the reduction of data, and the decomposition of the radial luminosity profiles. Attention is also given to the structure of the bars, a comparison with the Miller and Smith models, and a discussion of the results. The considered study has provided near-infrared surface photometry for the stellar bars of a number of barrel spiral galaxies. 53 references

  12. Microbial contamination of "In use" bar soap in dental clinics

    Directory of Open Access Journals (Sweden)

    Hegde P

    2006-01-01

    Full Text Available Bar soap from 18 different dental clinics were investigated for microbial contamination, while it was "in-use". Of the 32 samples obtained from the bar soap, 100% yielded positive culture. A total of 8 different genera of organisms were isolated. Each bar soap was found to harbor 2-5 different genera of micro organisms. Heavily used soap had more micro organisms compared to less used soap. The microbial load of the "in-use" bar soap constituted a mixed flora of gram positive, gram negative, aerobes, anaerobes, and fungi. The results indicate that the bar soap under "in-use" condition is a reservoir of microorganisms and handwashing with such a soap may lead to spread of infection.

  13. Polar Lipid Extraction

    OpenAIRE

    sprotocols

    2014-01-01

    Author: Biotechniques Polar lipids are generally extracted from dry cell material using chloroform:methanol:0.3% NaCl (1:2:0.8 v/v/v). This may be carried out by adding 9.5 ml of this mixture to 100 mg of freeze dried cells, or by adding a suitable amount of chloroform, methanol and 0.3% NaCl to the cell material, or to the aqueous methanolic phase remaining from the lipoquinone extraction. 1. The aqueous methanolic phase (4 ml total volume), together with the cell material from the ...

  14. Lipid-transfer proteins.

    Science.gov (United States)

    Ng, Tzi Bun; Cheung, Randy Chi Fai; Wong, Jack Ho; Ye, Xiujuan

    2012-01-01

    Lipid-transfer proteins (LTPs) are basic proteins found in abundance in higher plants. LTPs play lots of roles in plants such as participation in cutin formation, embryogenesis, defense reactions against phytopathogens, symbiosis, and the adaptation of plants to various environmental conditions. In addition, LTPs from field mustard and Chinese daffodil exhibit antiproliferative activity against human cancer cells. LTPs from chili pepper and coffee manifest inhibitory activity against fungi pathogenic to humans such as Candida species. The intent of this article is to review LTPs in the plant kingdom. PMID:23193591

  15. Mannosylerythritol lipids: a review.

    Science.gov (United States)

    Arutchelvi, Joseph Irudayaraj; Bhaduri, Sumit; Uppara, Parasu Veera; Doble, Mukesh

    2008-12-01

    Mannosylerythritol lipids (MELs) are surface active compounds that belong to the glycolipid class of biosurfactants (BSs). MELs are produced by Pseudozyma sp. as a major component while Ustilago sp. produces them as a minor component. Although MELs have been known for over five decades, they recently regained attention due to their environmental compatibility, mild production conditions, structural diversity, self-assembling properties and versatile biochemical functions. In this review, the MEL producing microorganisms, the production conditions, their applications, their diverse structures and self-assembling properties are discussed. The biosynthetic pathways and the regulatory mechanisms involved in the production of MEL are also explained here. PMID:18716809

  16. Bioactive lipids as modulators of immunity, inflammation and emotions.

    Science.gov (United States)

    Chiurchiù, Valerio; Maccarrone, Mauro

    2016-08-01

    Lipids are not only constituents of cellular membranes but also key signaling mediators, thus acting as 'bioactive lipids'. Among the prominent roles exerted by bioactive lipids are immune regulation, inflammation and maintenance of homeostasis. Accumulated evidence indicates the existence of a bidirectional relationship between immune and nervous systems, whereby inflammatory mediators can directly modulate emotions that, in turn, can strongly influence immune responses, thus affecting health. This review summarizes current knowledge on the ability of several families of bioactive lipids to regulate immunity and inflammation (through pro-inflammatory or anti-inflammatory effects), as well as to control emotions and mood-related manifestations, advocating these substances as an attractive interface between 'mind' and 'body', and as a potential target to treat inflammatory/immune-mediated mood disorders. PMID:27372887

  17. Revealing galactic scale bars with the help of Galaxy Zoo

    Science.gov (United States)

    Masters, Karen L.

    2015-03-01

    We use visual classifications of the brightest 250,000 galaxies in the Sloan Digital Sky Survey Main Galaxy Sample provided by citizen scientists via the Galaxy Zoo project (www.galaxyzoo.org, Lintott et al. 2008) to identify a sample of local disc galaxies with reliable bar identifications. These data, combined with information on the atomic gas content from the ALFALFA survey (Haynes et al. 2011) show that disc galaxies with higher gas content have lower bar fractions. We use a gas deficiency parameter to show that disc galaxies with more/less gas than expected for their stellar mass are less/more likely to host bars. Furthermore, we see that at a fixed gas content there is no residual correlation between bar fraction and stellar mass. We argue that this suggests previously observed correlations between galaxy colour/stellar mass and (strong) bar fraction (e.g. from the sample in Masters et al. 2011, and also see Nair & Abraham 2010) could be driven by the interaction between bars and the gas content of the disc, since more massive, optically redder disc galaxies are observed to have lower gas contents. Furthermore we see evidence that at a fixed gas content the global colours of barred galaxies are redder than those of unbarred galaxies. We suggest that this could be due to the exchange of angular momentum beyond co-rotation which might stop a replenishment of gas from external sources, and act as a source of feedback to temporarily halt or reduce the star formation in the outer parts of barred discs. These results (published as Masters et al. 2012) combined with those of Skibba et al. (2012), who use the same sample to show a clear (but subtle and complicated) environmental dependence of the bar fraction in disc galaxies, suggest that bars are intimately linked to the evolution of disc galaxies.

  18. Lipids of the Golgi membrane

    OpenAIRE

    van Meer, G.

    1998-01-01

    The thin membrane of the endoplasmic reticulum matures into the thick plasma membrane in the Golgi apparatus. Along the way, the concentrations of cholesterol and sphingolipids increase. Here, Gerrit van Meer discusses how this phenomenon may reflect an intricate lipid-protein sorting machinery. Synthesis of sphingolipids, translocation across the Golgi membrane and lateral segregation into lumenal domains seem to be key events. In addition, signalling lipids indicate the lipid status of the ...

  19. Absorption Of Dietary Lipid Components

    OpenAIRE

    Abdulkadir Hurşit

    2015-01-01

    Although the digestion and absorption of lipids that are necessary for the survival of living organisms are well known in general terms, nevertheless how different lipids to be digested, how it is distributed into the bloodstream, and how to be used by the cells, are unknown issues by most non specialist people. In recent years, knowledge of lipid digestion and absorption has expanded considerably. More insight has been gained in the mechanism of action of H + pump as a transport system in fa...

  20. Effects of the global regulator CsrA on the BarA/UvrY two-component signaling system.

    Science.gov (United States)

    Camacho, Martha I; Alvarez, Adrian F; Chavez, Ricardo Gonzalez; Romeo, Tony; Merino, Enrique; Georgellis, Dimitris

    2015-03-01

    The hybrid sensor kinase BarA and its cognate response regulator UvrY, members of the two-component signal transduction family, activate transcription of CsrB and CsrC noncoding RNAs. These two small RNAs act by sequestering the RNA binding protein CsrA, which posttranscriptionally regulates translation and/or stability of its target mRNAs. Here, we provide evidence that CsrA positively affects, although indirectly, uvrY expression, at both the transcriptional and translational levels. We also demonstrate that CsrA is required for properly switching BarA from its phosphatase to its kinase activity. Thus, the existence of a feedback loop mechanism that involves the Csr and BarA/UvrY global regulatory systems is exposed. PMID:25535275

  1. Effects of fatty acids on carbohydrates and lipids of canola seeds during germination

    OpenAIRE

    M.L.L. Ferrarese; C. R. S. Baleroni; O. Ferrarese-Filho

    1998-01-01

    The present work was carried out to investigate the effects of caprylic acid (C8) and oleic acid (C18) on carbohydrates and lipids during canola seed germination. The results showed that oleic acid influence carbohydrate concentration but did not influence lipid concentration. Significant results were found with caprylic acid that affected carbohydrates and lipids in cotyledons after three-day germination.O presente trabalho foi realizado com o objetivo de investigar os efeitos dos ácidos cap...

  2. Lawyers for Literacy. A Bar Leadership Manual. A Special Service Publication of the American Bar Association's Task Force on Literacy.

    Science.gov (United States)

    American Bar Association, Washington, DC.

    This manual is designed to provide materials to help state and local bar associations become involved with the literacy issue. Chapter 1 provides an overview of illiteracy as a very serious problem. Chapter 2 describes major public and private efforts to combat illiteracy. Chapter 3 explains why the bar associations should be involved. Chapter 4…

  3. $T \\bar{T}$-deformed 2D Quantum Field Theories

    CERN Document Server

    Cavaglià, Andrea; Szécsényi, István M; Tateo, Roberto

    2016-01-01

    It was noticed many years ago, in the framework of massless RG flows, that the irrelevant composite operator $T \\bar{T}$, built with the components of the energy-momentum tensor, enjoys very special properties in 2D quantum field theories, and can be regarded as a peculiar kind of integrable perturbation. Novel interesting features of this operator have recently emerged from the study of effective string theory models.In this paper we study further properties of this distinguished perturbation. We discuss how it affects the energy levels and one-point functions of a general 2D QFT in finite volume through a surprising relation with a simple hydrodynamic equation. In the case of the perturbation of CFTs, adapting a result by L\\"uscher and Weisz we give a compact expression for the partition function on a finite-length cylinder and make a connection with the exact $g$-function method. We argue that, at the classical level, the deformation naturally maps the action of $N$ massless free bosons into the Nambu-Goto...

  4. The $K \\bar K \\pi$ decay of the $f_1(1285)$ and its nature as a $K^* \\bar K -cc$ molecule

    OpenAIRE

    Aceti, F.; Xie, Ju-Jun; Oset, E

    2015-01-01

    We investigate the decay of $f_1(1285) \\to \\pi K \\bar K$ with the assumption that the $f_1(1285)$ is dynamically generated from the $K^* \\bar{K} - cc$ interaction. In addition to the tree level diagrams that proceed via $f_1(1285) \\to K^* \\bar{K} - cc \\to \\pi K \\bar K$, we take into account also the final state interactions of $K \\bar K \\to K \\bar K$ and $\\pi K \\to \\pi K$. The partial decay width and mass distributions of $f_1(1285) \\to \\pi K \\bar K$ are evaluated. We get a value for the part...

  5. Lipid hydroperoxides in plants.

    Science.gov (United States)

    Griffiths, G; Leverentz, M; Silkowski, H; Gill, N; Sánchez-Serrano, J J

    2000-12-01

    Hydroperoxides are the primary oxygenated products of polyunsaturated fatty acids and were determined spectrophotometrically based on their reaction with an excess of Fe2+ at low pH in the presence of the dye Xylenol Orange. Triphenylphosphine-mediated hydroxide formation was used to authenticate the signal generated by the hydroperoxides. The method readily detected lipid peroxidation in a range of plant tissues including Phaseolus hypocotyls (26 +/- 5 nmol.g of fresh weight(-1); mean +/- S.D.), Alstroemeria floral tissues (sepals, 66+/-13 nmol.g of fresh weight(-1); petals, 49+/-6 nmol.g of fresh weight(-1)), potato leaves (334+/-75 nmol.g of fresh weight(-1)), broccoli florets (568+/-68 nmol.g of fresh weight(-1)) and Chlamydomonas cells (602+/-40 nmol.g of wet weight(-1)). Relative to the total fatty acid content of the tissues, the percentage hydroperoxide content was within the range of 0.6-1.7% for all tissue types (photosynthetic and non-photosynthetic) and represents the basal oxidation level of membrane fatty acids in plant cells. Leaves of transgenic potato with the fatty acid hydroperoxide lyase enzyme expressed in the antisense orientation were elevated by 38%, indicating a role for this enzyme in the maintenance of cellular levels of lipid hydroperoxides. PMID:11171226

  6. Role of $Y(4630)$ in the $p\\bar{p}\\rightarrow\\Lambda_c\\bar{\\Lambda}_c$ reaction near threshold

    CERN Document Server

    Wang, Yan-Yan; Wang, En; li, De-Min

    2016-01-01

    We investigate the charmed baryon production reaction $p\\bar{p}\\rightarrow\\Lambda_c\\bar{\\Lambda}_c$ in an effective Lagrangian approach. Besides the $t$-channel $D^0$ and $D^{*0}$ mesons exchanges, the $s$-channel $Y(4630)$ meson exchange is taken into account. For the total cross sections, the $D^0$ and $D^{*0}$ mesons provide minor background contributions, while the $Y(4630)$ state gives a clear peak structure with the magnitude of 10 $\\mu$b at center of mass energy 4.63 GeV. Basing on the results, we suggest that the reaction of $p\\bar{p}\\rightarrow\\Lambda_c\\bar{\\Lambda}_c$ can be used to search for the $1^{--}$ charmonium-like $Y(4630)$ state, and our predictions can be tested in future by the $\\rm{\\bar PANDA}$ facility.

  7. Variation of Galactic Bar Length with Amplitude and Density as Evidence for Bar Growth over a Hubble Time

    CERN Document Server

    Elmegreen, Bruce G; Knapen, Johan H; Buta, Ronald J; Block, David L; Puerari, Ivanio

    2007-01-01

    K_s-band images of 20 barred galaxies show an increase in the peak amplitude of the normalized m=2 Fourier component with the R_25-normalized radius at this peak. This implies that longer bars have higher $m=2$ amplitudes. The long bars also correlate with an increased density in the central parts of the disks, as measured by the luminosity inside 0.25R_25 divided by the cube of this radius in kpc. Because denser galaxies evolve faster, these correlations suggest that bars grow in length and amplitude over a Hubble time with the fastest evolution occurring in the densest galaxies. All but three of the sample have early-type flat bars; there is no clear correlation between the correlated quantities and the Hubble type.

  8. Solid lipid nanoparticles for parenteral drug delivery

    NARCIS (Netherlands)

    Wissing, S.A.; Kayser, Oliver; Muller, R.H.

    2004-01-01

    This review describes the use of nanoparticles based on solid lipids for the parenteral application of drugs. Firstly, different types of nanoparticles based on solid lipids such as "solid lipid nanoparticles" (SLN), "nanostructured lipid carriers" (NLC) and "lipid drug conjugate" (LDC) nanoparticle

  9. Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites

    OpenAIRE

    Gong, Jingyi; Sun, Zhiqi; Wu, Lizhen; Xu, Wenyi; Schieber, Nicole; Xu, Dijin; Shui, Guanghou; Yang, Hongyuan; Parton, Robert G.; Li, Peng

    2011-01-01

    Lipid droplets (LDs) are dynamic cellular organelles that control many biological processes. However, molecular components determining LD growth are poorly understood. Genetic analysis has indicated that Fsp27, an LD-associated protein, is important in controlling LD size and lipid storage in adipocytes. In this paper, we demonstrate that Fsp27 is focally enriched at the LD–LD contacting site (LDCS). Photobleaching revealed the occurrence of lipid exchange between contacted LDs in wild-type a...

  10. Nuss procedure: Technical modifications to ease bending of the support bar and lateral stabilizer placement

    Directory of Open Access Journals (Sweden)

    Osman Zeki Karakus

    2016-01-01

    Conclusion: Preoperative bending of the support bar according to anthropometric measurements and fixation of the lateral stabilizers to the support bar in inverted position facilitates bar shaping and lateral stabilizer placement.

  11. Development of antileishmanial lipid nanocomplexes.

    Science.gov (United States)

    Pham, T T H; Gueutin, C; Cheron, M; Abreu, S; Chaminade, P; Loiseau, P M; Barratt, G

    2014-12-01

    Visceral leishmaniasis is a life-threatening disease that affects nearly a million people every year. The emergence of Leishmania strains resistant to existing drugs complicates its treatment. The purpose of this study was to develop a new lipid formulation based on nanocochleates combining two active drugs: Amphotericin B (AmB) and Miltefosine (HePC). Nanocochleates composed of dioleoylphosphatidylserine (DOPS) and Cholesterol (Cho) and Ca(2+), in which HePC and AmB were incorporated, were prepared. Properties such as particle size, zeta potential, drug payload, in-vitro drug release and storage stability were investigated. Moreover, in-vitro stability in gastrointestinal fluid was performed in view of an oral administration. AmB-HePC-loaded nanocochleates with a mean particle size of 250 ± 2 nm were obtained. The particles displayed a narrow size distribution and a drug payload of 29.9 ± 0.5 mg/g for AmB, and 14.0 ± 0.9 mg/g for HePC. Drug release occurred preferentially in intestinal medium containing bile salts. Therefore, AmB-HePC-loaded nanocochleates could be a promising oral delivery system for the treatment of visceral leishmaniasis. PMID:24952352

  12. Spitzer reveals what's behind Orion's Bar

    CERN Document Server

    Rubin, Robert H; O'Dell, C R; McNabb, Ian A; Colgan, Sean W J; Zhuge, Scott Y; Ferland, Gary J; Hidalgo, Sergio A

    2010-01-01

    We present Spitzer Space Telescope observations of 11 regions SE of the Bright Bar in the Orion Nebula, along a radial from the exciting star theta1OriC, extending from 2.6 to 12.1'. Our Cycle 5 programme obtained deep spectra with matching IRS short-high (SH) and long-high (LH) aperture grid patterns. Most previous IR missions observed only the inner few arcmin. Orion is the benchmark for studies of the ISM particularly for elemental abundances. Spitzer observations provide a unique perspective on the Ne and S abundances by virtue of observing the dominant ionization states of Ne (Ne+, Ne++) and S (S++, S3+) in Orion and H II regions in general. The Ne/H abundance ratio is especially well determined, with a value of (1.01+/-0.08)E-4. We obtained corresponding new ground-based spectra at CTIO. These optical data are used to estimate the electron temperature, electron density, optical extinction, and the S+/S++ ratio at each of our Spitzer positions. That permits an adjustment for the total gas-phase S abundan...

  13. Bond Strength of Composite CFRP Reinforcing Bars in Timber

    Directory of Open Access Journals (Sweden)

    Marco Corradi

    2015-07-01

    Full Text Available The use of near-surface mounted (NSM fibre-reinforced polymer (FRP bars is an interesting method for increasing the shear and flexural strength of existing timber members. This article examines the behaviour of carbon FRP (CFRP bars in timber under direct pull-out conditions. The objective of this experimental program is to investigate the bond strength between composite bars and timber: bars were epoxied into small notches made into chestnut and fir wood members using a commercially-available epoxy system. Bonded lengths varied from 150 to 300 mm. Failure modes, stress and strain distributions and the bond strength of CFRP bars have been evaluated and discussed. The pull-out capacity in NSM CFRP bars at the onset of debonding increased with bonded length up to a length of 250 mm. While CFRP bar’s pull-out was achieved only for specimens with bonded lengths of 150 and 200 mm, bar tensile failure was mainly recorded for bonded lengths of 250 and 300 mm.

  14. Shepherding Tidal Debris with the Galactic Bar: The Ophiuchus Stream

    Science.gov (United States)

    Hattori, Kohei; Erkal, Denis; Sanders, Jason L.

    2016-04-01

    The dynamics of stellar streams in rotating barred potentials is explained for the first time. Naturally, neighbouring stream stars reach pericentre at slightly different times. In the presence of a rotating bar, these neighbouring stream stars experience different bar orientations during pericentric passage and hence each star receives a different torque from the bar. These differing torques reshape the angular momentum and energy distribution of stars in the stream, which in turn changes the growth rate of the stream. For a progenitor orbiting in the same sense as the bar's rotation and satisfying a resonance condition, the resultant stream can be substantially shorter or longer than expected, depending on whether the pericentric passages of the progenitor occur along the bar's minor or major axis respectively. We present a full discussion of this phenomenon focusing mainly on streams confined to the Galactic plane. In stark contrast with the evolution in static potentials, which give rise to streams that grow steadily in time, rotating barred potentials can produce dynamically old, short streams. This challenges the traditional viewpoint that the inner halo necessarily consists of well phase-mixed material whilst the tidally-disrupted structures in the outer halo are more spatially coherent. We argue that this mechanism may play an important role in explaining the mysteriously short Ophiuchus stream that was recently discovered near the bulge region of the Milky Way.

  15. Shepherding tidal debris with the Galactic bar: the Ophiuchus stream

    Science.gov (United States)

    Hattori, Kohei; Erkal, Denis; Sanders, Jason L.

    2016-07-01

    The dynamics of stellar streams in rotating barred potentials is explained for the first time. Naturally, neighbouring stream stars reach pericentre at slightly different times. In the presence of a rotating bar, these neighbouring stream stars experience different bar orientations during pericentric passage and hence each star receives a different torque from the bar. These differing torques reshape the angular momentum and energy distribution of stars in the stream, which in turn changes the growth rate of the stream. For a progenitor orbiting in the same sense as the bar's rotation and satisfying a resonance condition, the resultant stream can be substantially shorter or longer than expected, depending on whether the pericentric passages of the progenitor occur along the bar's minor or major axis, respectively. We present a full discussion of this phenomenon focusing mainly on streams confined to the Galactic plane. In stark contrast with the evolution in static potentials, which give rise to streams that grow steadily in time, rotating barred potentials can produce dynamically old, short streams. This challenges the traditional viewpoint that the inner halo necessarily consists of well phase-mixed material whilst the tidally disrupted structures in the outer halo are more spatially coherent. We argue that this mechanism may play an important role in explaining the mysteriously short Ophiuchus stream that was recently discovered near the bulge region of the Milky Way.

  16. Formation and evolution of bars in disc galaxies

    CERN Document Server

    Athanassoula, E

    2002-01-01

    I follow a bar from its formation, via its evolution, to its destruction and, perhaps, regeneration. I discuss the main features at each stage and particularly the role of the halo. Bars can form even in sub-maximum discs. In fact, such bars can be stronger than bars which have grown in maximum discs. This is due to the response of the halo and, in particular, to the exchange of energy and angular momentum between the disc particles constituting the bar and the halo particles at resonance with it. The bar slowdown depends on the initial central concentration of the halo and the initial value of the disc Q. Contrary to the halo mass distribution, the disc changes its radial density profile considerably during the evolution. Applying the Sackett criterion, I thus find that discs become maximum in many simulations in which they have started off as sub-maximum. I briefly discuss the evolution if a gaseous component is present, as well as the destruction and regeneration of bars.

  17. The nature and nurture of bars and disks

    CERN Document Server

    Mendez-Abreu, J; Aguerri, J A L; Corsini, E M; Zarattini, S

    2012-01-01

    The effects that interactions produce on galaxy disks and how they modify the subsequent formation of bars need to be distinguished to fully understand the relationship between bars and environment. To this aim we derive the bar fraction in three different environments ranging from the field to Virgo and Coma clusters, covering an unprecedentedly large range of galaxy luminosities (or, equivalently, stellar masses). We confirm that the fraction of barred galaxies strongly depends on galaxy luminosity. We also show that the difference between the bar fraction distributions as a function of galaxy luminosity (and mass) in the field and Coma cluster are statistically significant, with Virgo being an intermediate case. The fraction of barred galaxies shows a maximum of about 50% at $M_r\\,\\simeq\\,-20.5$ in clusters, whereas the peak is shifted to $M_r\\,\\simeq\\,-19$ in the field. We interpret this result as a variation of the effect of environment on bar formation depending on galaxy luminosity. We speculate that b...

  18. Fourier Dissection of Early-Type Galaxy Bars

    CERN Document Server

    Buta, R; Salo, H; Block, D L; Knapen, J H

    2006-01-01

    This paper reports on a near-infrared survey of early-type galaxies designed to provide information on bar strengths, bulges, disks, and bar parameters in a statistically well-defined sample of S0-Sa galaxies. Early-type galaxies have the advantage that their bars are relatively free of the effects of dust, star formation, and spiral structure that complicate bar studies in later type galaxies. We describe the survey and present results on detailed analysis of the relative Fourier intensity amplitudes of bars in 26 early-type galaxies. We also evaluate the symmetry assumption of these amplitudes with radius, used recently for bar-spiral separation in later-type galaxies. The results show a wide variety of radial Fourier profiles of bars, ranging from simple symmetric profiles that can be represented in terms of a single gaussian component, to both symmetric and asymmetric profiles that can be represented by two overlapping gaussian components. More complicated profiles than these are also found, often due to ...

  19. Washing with contaminated bar soap is unlikely to transfer bacteria.

    Science.gov (United States)

    Heinze, J E; Yackovich, F

    1988-08-01

    Recent reports of the isolation of microorganisms from used soap bars have raised the concern that bacteria may be transferred from contaminated soap bars during handwashing. Since only one study addressing this question has been published, we developed an additional procedure to test this concern. In our new method prewashed and softened commercial deodorant soap bars (0.8% triclocarban) not active against Gram-negative bacteria were inoculated with Escherichia coli and Pseudomonas aeruginosa to give mean total survival levels of 4.4 X 10(5) c.f.u. per bar which was 70-fold higher than those reported on used soap bars. Sixteen panelists were instructed to wash with the inoculated bars using their normal handwashing procedure. After washing, none of the 16 panelists had detectable levels of either test bacterium on their hands. Thus, the results obtained using our new method were in complete agreement with those obtained with the previously published method even though the two methods differ in a number of procedural aspects. These findings, along with other published reports, show that little hazard exists in routine handwashing with previously used soap bars and support the frequent use of soap and water for handwashing to prevent the spread of disease. PMID:3402545

  20. Mechanisms of lipid regulation and lipid gating in TRPC channels.

    Science.gov (United States)

    Svobodova, Barbora; Groschner, Klaus

    2016-06-01

    TRPC proteins form cation channels that integrate and relay cellular signals by mechanisms involving lipid recognition and lipid-dependent gating. The lipohilic/amphiphilic molecules that function as cellular activators or modulators of TRPC proteins span a wide range of chemical structures. In this context, cellular redox balance is likely linked to the lipid recognition/gating features of TRPC channels. Both classical ligand-protein interactions as well as indirect and promiscuous sensory mechanisms have been proposed. Some of the recognition processes are suggested to involve ancillary lipid-binding scaffolds or regulators as well as dynamic protein-protein interactions determined by bilayer architecture. A complex interplay of protein-protein and protein-lipid interactions is likely to govern the gating and/or plasma membrane recruitment of TRPC channels, thereby providing a distinguished platform for signal integration and coincident signal detection. Both the primary molecular event(s) of lipid recognition by TRPC channels as well as the transformation of these events into distinct gating movements is poorly understood at the molecular level, and it remains elusive whether lipid sensing in TRPCs is conferred to a distinct sensor domain. Recent structural information on the molecular action of lipophilic activators in distantly related members of the TRP superfamily encourages speculations on TRPC gating mechanisms involved in lipid recognition/gating. This review aims to provide an update on the current understanding of the lipid-dependent control of TRPC channels with focus on the TRPC lipid sensing, signal-integration hub and a short discussion of potential links to redox signaling. PMID:27125985