WorldWideScience

Sample records for barrier free design

  1. Designing and Operating a Barrier Free Campus.

    Science.gov (United States)

    Potter, Laurie S.; Potter, George T.

    An account of the Ramapo College (New Jersey) experience in the design and development of a barrier-free campus includes discussion of the academic and service problems that arise in meeting the needs of handicapped students in college. Special attention is given to: campus bathrooms, campus housing (ramps, locks, bathrooms, roommate selection,…

  2. On barrier-free design for museums%博物馆的无障碍设计探析

    Institute of Scientific and Technical Information of China (English)

    贾祝军; 申黎明; 沈怡君

    2011-01-01

    The paper introduces the current status for the barrier-free design in museums in China,analyzes the shortages for the barrier-free design in museums in China,explores the barrier-free design in museums,indicates its important role for improving the service quality of the museums and the enhancing the construction of the harmonious society,and analyzes its development tendency in future,so as to enhance the better development of the barrier-free design for museums.%总结了我国博物馆无障碍设计的现状,分析了我国博物馆无障碍设计中的一些不足之处,并就此对博物馆无障碍设计进行了一些探索,说明了其对提高博物馆服务水平和推动建设和谐社会等方面的重要作用,对将来的发展趋势进行了分析,从而进一步促进博物馆无障碍设计更好的发展。

  3. Study on the Barrier-free Design in Airport Terminal%机场航站楼的无障碍设计研究

    Institute of Scientific and Technical Information of China (English)

    贾祝军; 申黎明

    2012-01-01

    本文在介绍我国机场航站楼的现状及无障碍设计概念的基础上,对无障碍人群及其生理特性进行了分析,探讨了机场航站楼无障碍设计的设计原则,并提出了针对性建议.%Based on the introduction of domestic airport terminal's current situation and barrier-free design's definition, the author analyze barrier-free users and users' physiological characteristics, explores the design principles of airport terminal's barrier-free design. Specific suggestions on barrier-free design are given according to the airport terminal.

  4. 谈无障碍设计在居室的应用%On application of barrier-free design at residential rooms

    Institute of Scientific and Technical Information of China (English)

    何依航

    2012-01-01

    通过对人口现状的调查,阐述了无障碍设计的重要性以及无障碍设计概念意识层面的提高与普及,并分析了无障碍设计在居室设计中的推广与应用,为弱势群体的生活需要提供了保障。%According to the investigation over the population, the study illustrates the importance of the barrier-free design and the improvement and publicity of the barrier-free design at the ideological layer, and analyzes the extension and application of the barrier-free design in residential rooms, so as to provide the guarantee for the life of vulnerable people.

  5. 工程项目建设无障碍设计的实践与探究%Practice and discuss on barrier-free design of construction project

    Institute of Scientific and Technical Information of China (English)

    肖山

    2013-01-01

      以项目建设无障碍设计实践为案例,从无障碍集成化统筹设计、面对不同类别残障人士的对象差别化设计、针对气候经济社会条件差异的地域化无障碍设计几个方面深入探讨了工程建设人性化无障碍设计的问题。%This paper takes the design practice of barrier-free project construction as the study case, no obstacle integrated overall design, object-oriented different types of the disabled differentiation design, according to the regional differences in climate of economic and social conditions of the barrier-free design aspects discussed the construction of barrier-free design of humanization

  6. A Research of Barrier-free Design of Residential Environment%住宅环境中的无障碍设计探究

    Institute of Scientific and Technical Information of China (English)

    周凌琳; 王淮梁

    2015-01-01

    The barrier-free design of residential environment, a compass to show the respect for human rights and social morality, can provide disabled people with some convenience and more jobs, and make them better participate in national social security system.A good residential environment is not only convenient for disabled people’ s life, but also able to alleviate the psychological barriers of disabled people and help them integrate into the society better.%住宅环境的无障碍设计是尊重人权、体现社会道德的指南针,它能给残疾人群的居住和外出带来一定的便利,同时也能给残疾人群提供更多的工作岗位,从而更好地参与国家所实行的社保制度。一个好的住宅环境不光是方便残疾人的生活,还要能够缓和残疾人的心理障碍,帮助他们更好地融入社会。

  7. Analysis of Barrier-free Design of Slow Traffic System——Taking Changshu City as an Example%常熟市慢行系统无障碍设计探讨

    Institute of Scientific and Technical Information of China (English)

    李三毛

    2012-01-01

    Most of the service objects of the current studies are the able-bodied adult,thus the design of products often can not meet the accessibility requirements of disabled people.To give disabled people a better life,this paper makes researches on handicapped accessibility design. This paper introduces the development and status quo of handicapped accessibility design at home and abroad,discusses the content,purpose and significance of barrier-free design,and makes a clear definition of the core concepts.Besides,through describing the range of project planning in detail,and analysing the requirements of barrier-free design,the paper determines the barrier-free design principles,and conducts in-depth design of barrier-free design,which meet the requirements of disabled people.%论述了无障碍设计内容、目的和意义,对其核心概念进行了明确的界定。探讨了无障碍设计要求、无障碍设计原则,提出了无障碍设计整体规划,设计出了符合残障者要求的慢行系统。

  8. 谈厨房空间的无障碍设计%Discussion on barrier-free design of kitchen space

    Institute of Scientific and Technical Information of China (English)

    钱治科; 盛那

    2012-01-01

    深入分析老年人的生理特点和活动规律,结合室内设计中人体工程学和心理学的相关知识,分析厨房设计中存在的问题,并且运用无障碍设计的方法,为老年人设计一个更加人性化的厨房环境,确保老年人在厨房空间的方便和安全,提高老年人的自理能力和自信心。%This paper in-depth analyzed the physiological characteristics and activity patterns of the older people, combining with the related knowledge of ergonomics and psychology in interior design, analyzed the existing problems in the kitchen design, and used the barrier-free design method, designed a more user-friendly kitchen environment for the older people, ensure the convenience and safety of older people in the kitchen space, improved the self-care ability and self-confidence of older people.

  9. 浅谈卫生间的无障碍设计%Discussion on Barrier-free Design of Toilet

    Institute of Scientific and Technical Information of China (English)

    钱治科; 盛那

    2013-01-01

    Toilet because of the diversity and particularity of the small space intensive furniture and use, is the most special space in the living space, especially for older people, if poorly designed, will give the elderly caused a lot of inconvenience and even endanger the safety of life, so we want to analyze usage behavior of the elderly in the bathroom, there may be found in the course of obstacles, and through the graphic design, the inside layout, detail design, the elderly bathroom accessibility design to meet the needs of the elderly, to ensure the security of the elderly.%卫生间由于其小空间、高密度的家具和使用方式的多样性和特殊性,是居住空间中最为特殊的空间,尤其对老年人来说,若设计不当,会给老年人造成很大的不便,甚至危及到生命安全,所以,本文想通过对老年人在卫生间的使用行为进行分析,发现在使用过程中可能存在的障碍,并通过平面设计、里面布置、细节设计等方面,进行老年人卫生间的无障碍设计,满足老年人的使用需求,保证老年人使用的安全性.

  10. Prototype Hanford Surface Barrier: Design basis document

    International Nuclear Information System (INIS)

    The Hanford Site Surface Barrier Development Program (BDP) was organized in 1985 to develop the technology needed to provide a long-term surface barrier capability for the Hanford Site and other arid sites. This document provides the basis of the prototype barrier. Engineers and scientists have momentarily frozen evolving barrier designs and incorporated the latest findings from BDP tasks. The design and construction of the prototype barrier has required that all of the various components of the barrier be brought together into an integrated system. This integration is particularly important because some of the components of the protective barreir have been developed independently of other barreir components. This document serves as the baseline by which future modifications or other barrier designs can be compared. Also, this document contains the minutes of meeting convened during the definitive design process in which critical decisions affecting the prototype barrier's design were made and the construction drawings

  11. Barrier-Free Design of Passenger Trains in China%中国铁路客车无障碍设计研究

    Institute of Scientific and Technical Information of China (English)

    向泽锐; 徐伯初; 支锦亦; 董石羽; 郭小锋; 章勇

    2014-01-01

    为获取我国铁路客车无障碍设计的相关依据,从分析乘客的需求出发,先后建立了行动不便旅客乘坐铁路客车的需求模型、车厢的无障碍流线模型和无障碍区域的基本布局模型,对比得出了最优的理论布局方案;通过真人实验和虚拟人仿真研究,明确了轮椅回转空间、通行宽度、轮椅使用者手的可及范围等关键尺寸;最后整理提出了我国铁路客车无障碍信息符号及其放置位置.研究结果表明:我国铁路客车应设有优先座位、专用无障碍车厢和通用齐全的无障碍信息符号;宜将轮椅席位和无障碍厕所集中设置于无障碍车厢侧门入口处的两侧;优先座位数应不低于每列车总席位的5%;列车8节及以下数量编组时应设置1个轮椅席位,8节以上编组时应设置2个轮椅席位;无障碍流线上的转弯处应预留轮椅转弯空间,直径应不小于1500 mm;通行的最小宽度应不小于950 mm;操控设备宜安装于离地板面高389~1354 mm范围;操作台面深度宜小于423 mm.%To find out the solution for barrier-free design of passenger trains in China,three models were proposed by analyzing the passengers special needs,including the demand model of passenger with reduced mobility,the accessible passageway model of coach,and the basic layout model of wheelchair accessible zone. Then,the theoretically optimal layout was obtained by comparing the all schemes. By both human tests and virtual simulations,some key dimensions were determined for barrier-free design of passenger trains,such as wheelchair turning space,passage width,and the controllable range of wheelchair users' hands. Further, the accessibility information symbols in passenger trains were introduced and some suggestions were provided for their places. The results show that trains should be equipped with priority seats,accessible coach and accessibility information symbols. Wheelchair

  12. On Electrical Design Scheme of Calling System in Barrier-free Facilities%无障碍设施呼叫系统的电气设计方案探讨

    Institute of Scientific and Technical Information of China (English)

    邵敏

    2011-01-01

    无障碍设施呼叫系统能满足残障者的求助需求,对维护无障碍化环境的安全、可靠和稳定具有十分重要的作用.基于实体工程中常见的几种呼叫系统,对其电气设计方案进行了归纳、分析和探讨,并对无障碍场所配电设计应注意的问题进行了分析.%Calling system in barrier-free facilities can meet disabled people's recourse requirement and has very important effect in maintaining safety,reliableness and stability of barrier-free environment.Based on several kinds of common calling systems in practical engineering,this paper carries out inductions,analyses and studies on their electrical design schemes and analyses problems of distribution design in barrier-free places.

  13. Multilayer barrier films comprising nitrogen spacers between free-standing barrier layers

    Science.gov (United States)

    Granstrom, Jimmy Erik

    The air sensitivity of organic electronic devices has delayed the broad commercialization of the printed "plastics" electronics technology. The vacuum deposition methods used to fabricate multi-layers which fulfill the encapsulation requirements for plastic electronic devices are complex and expensive. Fully printed "plastic" electronics requires the development of encapsulation architectures which comprise solution deposited barriers and/or low-cost free-standing barrier films based on polymers, e.g. poly ethylene terephthalate (PET). One way to reach this goal is the insertion of contaminant-free (e.g. pure N2) gas-phase spacers between free-standing barrier films in a multilayer structure. The spacers themselves do not exhibit any barrier properties (diffusion of gas permeants in a gas phase is orders of magnitude faster than in a solid), but they delay the attainment of steady state. The spacer also reduces the chemical potential gradient across downstream barrier layers during the transient regime, reducing permeation rate to the device. Furthermore, if sorption is not fully equilibrated and introduces a kinetic barrier to transport, the additional sorption and desorption steps needed for permeant to reach the device may also slow the steady-state permeation rate. Encapsulation architectures utilizing both single-matrix (without nitrogen spacers) and multiple-matrix structures (with nitrogen spacers) were fabricated in this study, including Russian Doll structures utilizing pairs of free-standing barrier films and epoxy seals separated by nitrogen spacers. This structure enables the use of low-cost epoxy to attach two or more free-standing barrier films to a substrate with improved barrier performance. The performance of various Russian Doll encapsulations was evaluated with the calcium thin film optical transmission test, showing improved performance of the Russian doll configuration relative to a non-nested barrier/spacer architecture, and demonstrating that

  14. E-Business Barriers in Iran's Free Trade Zones

    OpenAIRE

    Mohammad A. Sarlak; Asghar A. Hastiani

    2008-01-01

    Currently there are 24 free trade and special economic zones in Iran. Problem Statement: of these zones is lack of e-business and this is in spite of managements' desire to have proper infrastructure for e-business in these zones. The goal of this study is to determine and explain e-business barriers in free trade and special economic zones in Iran. Approach: Our approach in this study is based-on Delphi method. We used Delphi method to conduct our study and chose 25 members for our Delphi pa...

  15. 中外无障碍出行比较研究%Study on Comparison of Barrier-free Travel in China and Foreign Countries

    Institute of Scientific and Technical Information of China (English)

    贾祝军; 申黎明; 来增祥

    2012-01-01

    本文在介绍我国残疾人的现状及无障碍设计概念的基础上,对无障碍人群进行了分析,探讨了无障碍设计的原则,对国内外的无障碍出行方式进行了比较研究.%Based on the introduction of the disabled people's current situation and barrier-free design's definition, the author analyzes barrier-free users and explores the principles of barrier-free design. Study on comparison of barrier-free travel in China and Foreign countries.

  16. Model assessment of protective barrier designs: Part 2

    International Nuclear Information System (INIS)

    Protective barriers are being considered for use at the Hanford Site to enhance the isolation of radioactive wastes from water, plant, and animal intrusion. This study assesses the effectiveness of protective barriers for isolation of wastes from water. In this report, barrier designs are reviewed and several barrier modeling assumptions are tested. 20 refs., 16 figs., 6 tabs

  17. Storm Surge Barrier: Overview and Design Considerations

    NARCIS (Netherlands)

    Mooyaart, L.F.; Jonkman, S.N.; De Vries, P.A.L.; Van der Toorn, A.; Van Ledden, M.

    2014-01-01

    In this study an overview of existing and planned storm surge barriers in the world is provided. A systematic analysis relates functional requirements (e.g. navigation and tidal exchange) to the main barrier characteristics (e.g. gate type, dimensions). Furthermore, as the costs of barriers are an i

  18. Encouraging a 'Barrier-free Built Environment' in a Malaysian University

    Directory of Open Access Journals (Sweden)

    Hazreena Hussein

    2005-12-01

    Full Text Available A good pedestrian network around the campus should be accessible and friendly for all users including disabled persons. The environment should offer some activity nodes to ensure that the learning and working in campus is more pleasant. The paper will clarify the importance of collaborative development among various professionals and organisations in order to achieve a 'barrier-free built environment', focusing on the University of Malaya as a case study. It will share experience on the education of inclusive design for students who will become professionals and responsible in implementing the legislation relating to safety, accessibility and usability of the built environment. As the objective is the issue of educating relevant professionals, it will introduce methods in teaching professionals as a strategy to advocate a 'barrier-free built environment'. The paper will also illustrate the efforts done in encouraging the agenda which have been implemented around the case study.

  19. Modeling the Catalysis of Anti-Cocaine Catalytic Antibody: Competing Reaction Pathways and Free Energy Barriers

    OpenAIRE

    Pan, Yongmei; Gao, Daquan; Zhan, Chang-Guo

    2008-01-01

    The competing reaction pathways and the corresponding free energy barriers for cocaine hydrolysis catalyzed by an anti-cocaine catalytic antibody, mAb 15A10, were studied by using a novel computational strategy based on the binding free energy calculations on the antibody binding with cocaine and transition states. The calculated binding free energies were used to evaluate the free energy barrier shift from the cocaine hydrolysis in water to the antibody-catalyzed cocaine hydrolysis for each ...

  20. 学生公寓无障碍门禁防盗系统的设计与实现%Design and Implementation of Barrier-Free Access Control System in Dormitory

    Institute of Scientific and Technical Information of China (English)

    朱葛俊; 张硕; 朱文龙

    2011-01-01

    The security of dormitory is related to the teaching and life order of school.According to the characteristics of dormitory,barrier-free access control system was developed based on RFID technology and multimedia video technology.Real-time,safely and effi%学生公寓的安全关系到学校的正常教学和生活秩序。根据学生公寓的特点,开发了基于无线射频识别技术和多媒体视频技术相结合的无障碍门禁系统。该系统在不妨碍学生正常通行的情况下,实现了学生公寓管理的实时、安全和高效,较好地解决了学生公寓管理的一些难题。

  1. Leading of Public Facilities from Non-Barrier Design to Universal Design

    OpenAIRE

    Wenting Dai

    2009-01-01

    The universal design is the best way for today’s design of public facilities. It develops from the non-barrier design and turns to be perfect. Starting from concluding the differences of non-barrier design and universal design in practice, this paper analyzes and describes the process of from non-barrier design to universal design, aiming at form a complete, systematic, and correct recognition toward the universal design.

  2. Use of computer modeling to aid in hydraulic barrier design

    International Nuclear Information System (INIS)

    Releases of No. 6 and No. 4 fuel oil were discovered at a private boarding school. The releases impact a nearby pond with non-aqueous phase liquid hydrocarbon (NAPL), and threaten to impact an adjacent wetland. Prior to implementation of a permanent remedial solution, such as surfactant treatment and bioremediation, immediate containment of the NAPL was proposed via a barrier-gate containment system. The proposed barrier-gate containment system consisted of a high-density polyethylene barrier, horizontal wells, three flow-through gates, and downgradient infiltration galleries. Computer modeling of groundwater and NAPL flow was conducted utilizing a finite element multiphase model to evaluate the impacts to local hydrogeology associated with the barrier. These impacts included upgradient groundwater mounding and restriction of groundwater flux to the wetland. Model simulations aided in the identification of improvements to the initial barrier design and guided subsequent design modifications. Results of the simulations indicate the usefulness of computer modeling in containment system design

  3. 基于无障碍设计理念的产品设计研究--以视觉障碍者为例%Analyses on the Product Design Based on Barrier-free Concept:Taking Visual Disabilities as an Example

    Institute of Scientific and Technical Information of China (English)

    文艳群

    2013-01-01

      努力消除障碍,为使用者提供最大可能的方便是无障碍设计理念的核心。从无障碍设计角度出发,对其现状和发展方向进行分析;以视觉障碍者为研究对象,对其生理、行为、需求特征进行考察;以“盲画娱乐设备”为案例展开产品设计思路的探讨,目的是要呼吁产品设计倾注对弱势人群的“恻隐之心”,彰显设计的人性化和人情味。%The core of barrier-free design lies in trying the best to remove obstacles and providing utmost convenience for users. This paper summarizes the statues and development direction of barrier-free design, sampling visual disabilities and analyzing their physiological features, behaviors and needs. The process of product design will be discussed with the example of"recreational painting device for visual disabilities", so as to call for more benevolence to disadvantaged groups in product design, demonstrating humanness and kindness.

  4. The application of barrier-free facilities in shopping centres in Hong Kong

    OpenAIRE

    Chan, Chun-chun; 陳真真

    2015-01-01

    This discussion studies the application of barrier-free facilities in shopping centres in Hong Kong. Through literature review of “barrier-free” concept and the oversea examples, the meaning of “barrier-free” is discussed. This study targets three categories of shopping centres namely shopping centers owned by The Hong Kong Housing Authority (the Housing Authority), shopping centres owned and managed by the Link and shopping centres privately owned by single developer. Via literature review, ...

  5. The Functional Requirements and Design Basis for Information Barriers

    Energy Technology Data Exchange (ETDEWEB)

    Fuller, James L.

    2012-05-01

    This report summarizes the results of the Information Barrier Working Group workshop held at Sandia National Laboratory in Albuquerque, NM, February 2-4, 1999. This workshop was convened to establish the functional requirements associated with warhead radiation signature information barriers, to identify the major design elements of any such system or approach, and to identify a design basis for each of these major elements. Such information forms the general design basis to be used in designing, fabricating, and evaluating the complete integrated systems developed for specific purposes.

  6. Subsurface barrier design alternatives for confinement and controlled advection flow

    International Nuclear Information System (INIS)

    Various technologies and designs are being considered to serve as subsurface barriers to confine or control contaminant migration from underground waste storage or disposal structures containing radioactive and hazardous wastes. Alternatives including direct-coupled flood and controlled advection designs are described as preconceptual examples. Prototype geotechnical equipment for testing and demonstration of these alternative designs tested at the Hanford Geotechnical Development and Test Facility and the Hanford Small-Tube Lysimeter Facility include mobile high-pressure injectors and pumps, mobile transport and pumping units, vibratory and impact pile drivers, and mobile batching systems. Preliminary laboratory testing of barrier materials and additive sequestering agents have been completed and are described

  7. Calculation and visualization of free energy barriers for several VOCs and TNT in HKUST-1.

    Science.gov (United States)

    Sarkisov, Lev

    2012-11-28

    A simple protocol based on a lattice representation of the porous space is proposed to locate and characterize the free energy bottle-necks in rigid metal organic frameworks. As an illustration we apply this method to HKUST-1 to demonstrate that there are impassable free energy barriers for molecules of trinitrotoluene in this structure. PMID:23069936

  8. Calculation and visualization of free energy barriers for several VOCs and TNT in HKUST-1

    OpenAIRE

    Sarkisov, Lev

    2012-01-01

    A simple protocol based on a lattice representation of the porous space is proposed to locate and characterize the free energy bottle-necks in rigid metal organic frameworks. As an illustration we apply this method to HKUST-1 to demonstrate that there are impassable free energy barriers for molecules of trinitrotoluene in this structure.

  9. Barriers and Challenges in the Integrated Design Process Approcach

    DEFF Research Database (Denmark)

    Knudstrup, Mary-Ann

    2006-01-01

    agreement for reducing the global heating. This paper will briefly present the method of the Integrated Design Process, IDP [1]. It describes the background and means for developing a new method for designing integrated architecture in an interdisciplinary approach between architecture and engineering. It...... also describes the barriers and the challenges that must be overcome when trying to cross the borders between the two fields of engineering and architecture to design sustainable architecture....

  10. 轮/履耦合式无障碍轮椅系统设计及运动分析%Design and Kinematic Analysis of Barrier-free Wheelchair System with a Wheel-tracked Coupling Mechanism

    Institute of Scientific and Technical Information of China (English)

    王冬晓; 高学山; 刘云辉

    2012-01-01

    针对目前城市障碍环境下对无障碍轮椅的运动需求,将轮式移动快速性的优点和履带式移动的高越障性的优点有机地加以组合,研制开发了一种多运动模式的轮/履耦合式无障碍轮椅.其特点在于结构紧凑,通过内部变形机构和弹性履带能够快速便捷的对轮式和履带式进行自由转换,同时通过系统自动调节轮椅座椅位置和倾斜度,能够实现智能重心控制并保证轮椅的安全性和舒适性.对该轮椅的结构设计、运动特性、越障性能以及重心平衡控制功能进行了详细的分析.采用模糊控制的方法保证了无障碍轮椅调节响应速度快以及安全可靠性好的控制要求.仿真分析表明,这种无障碍轮椅具有很好的环境适应性和较高的越障能力.%The intention in the present paper is to provide a novel berried-free wheelchair with a wheel-tracked deformable mechanism for the needs in urban obstacle environment in general. To combine the advantages of normal wheelchair and crawler wheelchair, for example rapidity and high over-obstacle ability, we design a wheel-tracked deformable mechanism and an elastic crawler which can help the wheelchair to do the mode conversion from wheel to track quickly. Moreover, it also presents a fuzzy method for adjusting the gravity center and controlling inclination of a stair-climbing wheelchair. To validate the proposed berried-free wheelchair, we have carried out simulations with analysis. The results demonstrate that the wheelchair has good environmental adaptability and high over-obstacle ability.

  11. HEURISTIC OPTIMIZATION AND ALGORITHM TUNING APPLIED TO SORPTIVE BARRIER DESIGN

    Science.gov (United States)

    While heuristic optimization is applied in environmental applications, ad-hoc algorithm configuration is typical. We use a multi-layer sorptive barrier design problem as a benchmark for an algorithm-tuning procedure, as applied to three heuristics (genetic algorithms, simulated ...

  12. Designing coupled free-form surfaces.

    Science.gov (United States)

    Hicks, R Andrew; Croke, Christopher

    2010-10-01

    The problem of designing optical systems that contain free-form surfaces is a challenging one, even in the case of designing a single surface. Here we present a method for the coupled design of two free-form reflective surfaces that will have a prescribed distortion. On one hand, the method can be described using traditional vectors and matrices, which we do, but it is motivated by viewing the problem in the language of distributions from differential geometry and makes use of the exterior differential systems, which we relegate to an appendix. Example applications are given to the design of a mirror pair that increases the field of view of an observer, a similar mirror pair that also rotates the observer's view, and a pair of mirrors that give the observer a traditional panoramic strip view of the scene.

  13. Calculation of Free Energy Barriers to the Fusion of Small Vesicles☆

    OpenAIRE

    Lee, J Y; Schick, M.

    2008-01-01

    The fusion of small vesicles, either with a planar bilayer or with one another, is studied using a microscopic model in which the bilayers are composed of hexagonal- and lamellar-forming amphiphiles. The free energy of the system is obtained within the self-consistent field approximation. We find that the free energy barrier to form the initial stalk is hardly affected by the radius of the vesicle, but that the barrier to expand the hemifusion diaphragm and form a fusion pore decreases rapidl...

  14. Computational design and experimental validation of new thermal barrier systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin [Louisiana State Univ., Baton Rouge, LA (United States)

    2015-03-31

    The focus of this project is on the development of a reliable and efficient ab initio based computational high temperature material design method which can be used to assist the Thermal Barrier Coating (TBC) bond-coat and top-coat design. Experimental evaluations on the new TBCs are conducted to confirm the new TBCs’ properties. Southern University is the subcontractor on this project with a focus on the computational simulation method development. We have performed ab initio density functional theory (DFT) method and molecular dynamics simulation on screening the top coats and bond coats for gas turbine thermal barrier coating design and validation applications. For experimental validations, our focus is on the hot corrosion performance of different TBC systems. For example, for one of the top coatings studied, we examined the thermal stability of TaZr2.75O8 and confirmed it’s hot corrosion performance.

  15. Direct measurement of free-energy barrier to nucleation of crystallites in amorphous silicon thin films

    Science.gov (United States)

    Shi, Frank G.

    1994-01-01

    A method is introduced to measure the free-energy barrier W(sup *), the activation energy, and activation entropy to nucleation of crystallites in amorphous solids, independent of the energy barrier to growth. The method allows one to determine the temperature dependence of W(sup *), and the effect of the preparation conditions of the initial amorphous phase, the dopants, and the crystallization methds on W(sup *). The method is applied to determine the free-energy barrier to nucleation of crystallites in amorphous silicon (a-Si) thin films. For thermally induced nucleation in a-Si thin films with annealing temperatures in the range of from 824 to 983 K, the free-energy barrier W(sup *) to nucleation of silicon crystals is about 2.0 - 2.1 eV regardless of the preparation conditions of the films. The observation supports the idea that a-Si transforms into an intermediate amorphous state through the structural relaxation prior to the onset of nucleation of crystallites in a-Si. The observation also indicates that the activation entropy may be an insignificant part of the free-energy barrier for the nucleation of crystallites in a-Si. Compared with the free-energy barrier to nucleation of crystallites in undoped a-Si films, a significant reduction is observed in the free-energy barrier to nucleation in Cu-doped a-Si films. For a-Si under irradiation of Xe(2+) at 10(exp 5) eV, the free-energy barrier to ion-induced nucleation of crystallites is shown to be about half of the value associated with thermal-induced nucleation of crystallites in a-Si under the otherwise same conditions, which is much more significant than previously expected. The present method has a general kinetic basis; it thus should be equally applicable to nucleation of crystallites in any amorphous elemental semiconductors and semiconductor alloys, metallic and polymeric glasses, and to nucleation of crystallites in melts and solutions.

  16. Estimation of protein folding free energy barriers from calorimetric data by multi-model Bayesian analysis.

    Science.gov (United States)

    Naganathan, Athi N; Perez-Jimenez, Raul; Muñoz, Victor; Sanchez-Ruiz, Jose M

    2011-10-14

    The realization that folding free energy barriers can be small enough to result in significant population of the species at the barrier top has sprouted in several methods to estimate folding barriers from equilibrium experiments. Some of these approaches are based on fitting the experimental thermogram measured by differential scanning calorimetry (DSC) to a one-dimensional representation of the folding free-energy surface (FES). Different physical models have been used to represent the FES: (1) a Landau quartic polynomial as a function of the total enthalpy, which acts as an order parameter; (2) the projection onto a structural order parameter (i.e. number of native residues or native contacts) of the free energy of all the conformations generated by Ising-like statistical mechanical models; and (3) mean-field models that define conformational entropy and stabilization energy as functions of a continuous local order parameter. The fundamental question that emerges is how can we obtain robust, model-independent estimates of the thermodynamic folding barrier from the analysis of DSC experiments. Here we address this issue by comparing the performance of various FES models in interpreting the thermogram of a protein with a marginal folding barrier. We chose the small α-helical protein PDD, which folds-unfolds in microseconds crossing a free energy barrier previously estimated as ~1 RT. The fits of the PDD thermogram to the various models and assumptions produce FES with a consistently small free energy barrier separating the folded and unfolded ensembles. However, the fits vary in quality as well as in the estimated barrier. Applying Bayesian probabilistic analysis we rank the fit performance using a statistically rigorous criterion that leads to a global estimate of the folding barrier and its precision, which for PDD is 1.3 ± 0.4 kJ mol(-1). This result confirms that PDD folds over a minor barrier consistent with the downhill folding regime. We have further

  17. Free energy barrier for dissociation of the guanosine monophosphate anion in water

    Science.gov (United States)

    Cornetta, Lucas M.; Coutinho, Kaline; Canuto, Sylvio; Varella, Márcio T. do N.

    2016-08-01

    We report free energy barriers for the ground-state dissociation of the guanosine nucleotide anion in solution, employing implicit and explicit solvation models. The latter was based on the Free Energy Perturbation technique and Monte Carlo simulations. For the lowest-energy structure, both solvation models indicate a solvent-induced transition from a dipole-bound state in the gas phase to a π∗ valence state in solution. The free barrier estimates obtained from explicit and implicit solvation are in fair agreement with each other, although significantly overestimated in comparison to a previously reported explicit solvation model based on ab initio molecular dynamics simulations. Accounting for corrections related to the different DFT functionals used in the present and previous studies significantly improves the agreement. Contribution to the Topical Issue "Advances in Positron and Electron Scattering", edited by Paulo Limao-Vieira, Gustavo Garcia, E. Krishnakumar, James Sullivan, Hajime Tanuma and Zoran Petrovic.

  18. Directed site exploration for permeable reactive barrier design

    Science.gov (United States)

    Lee, J.; Graettinger, A.J.; Moylan, J.; Reeves, H.W.

    2009-01-01

    Permeable reactive barriers (PRBs) are being employed for in situ site remediation of groundwater that is typically flowing under natural gradients. Site characterization is of critical importance to the success of a PRB. A design-specific site exploration approach called quantitatively directed exploration (QDE) is presented. The QDE approach employs three spatially related matrices: (1) covariance of input parameters, (2) sensitivity of model outputs, and (3) covariance of model outputs to identify the most important location to explore based on a specific design. Sampling at the location that most reduces overall site uncertainty produces a higher probability of success of a particular design. The QDE approach is demonstrated on the Kansas City Plant, Kansas City, MO, a case study where a PRB was installed and failed. It is shown that additional quantitatively directed site exploration during the design phase could have prevented the remedial failure that was caused by missing a geologic body having high hydraulic conductivity at the south end of the barrier. The most contributing input parameter approach using head uncertainty clearly indicated where the next sampling should be made toward the high hydraulic conductivity zone. This case study demonstrates the need to include the specific design as well as site characterization uncertainty when choosing the sampling locations. ?? 2008 Elsevier B.V.

  19. Directed site exploration for permeable reactive barrier design.

    Science.gov (United States)

    Lee, Jejung; Graettinger, Andrew J; Moylan, John; Reeves, Howard W

    2009-02-15

    Permeable reactive barriers (PRBs) are being employed for in situ site remediation of groundwater that is typically flowing under natural gradients. Site characterization is of critical importance to the success of a PRB. A design-specific site exploration approach called quantitatively directed exploration (QDE) is presented. The QDE approach employs three spatially related matrices: (1) covariance of input parameters, (2) sensitivity of model outputs, and (3) covariance of model outputs to identify the most important location to explore based on a specific design. Sampling at the location that most reduces overall site uncertainty produces a higher probability of success of a particular design. The QDE approach is demonstrated on the Kansas City Plant, Kansas City, MO, a case study where a PRB was installed and failed. It is shown that additional quantitatively directed site exploration during the design phase could have prevented the remedial failure that was caused by missing a geologic body having high hydraulic conductivity at the south end of the barrier. The most contributing input parameter approach using head uncertainty clearly indicated where the next sampling should be made toward the high hydraulic conductivity zone. This case study demonstrates the need to include the specific design as well as site characterization uncertainty when choosing the sampling locations. PMID:18573602

  20. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2012-10-01

    This project (10/01/2010-9/30/2013), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This project will directly support the technical goals specified in DEFOA- 0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. We will develop and implement novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; perform material characterizations and oxidation/corrosion tests; and demonstrate our new thermal barrier coating (TBC) systems experimentally under integrated gasification combined cycle (IGCC) environments. The durability of the coating will be examined using the proposed Durability Test Rig.

  1. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2014-04-01

    This project (10/01/2010-9/30/2014), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This project will directly support the technical goals specified in DE-FOA-0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. In this project, the focus is to develop and implement novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; perform material characterizations and oxidation/corrosion tests; and demonstrate our new thermal barrier coating (TBC) systems experimentally under integrated gasification combined cycle (IGCC) environments.

  2. SCC free design for nuclear steam turbine

    International Nuclear Information System (INIS)

    One of the major material degradation experiences in the nuclear turbine industry was LP rotor disc stress corrosion cracking (SCC). Besides basic laboratory researches, field monitoring tests in actual steam condition in service have been continuously conducted for 30 years to confirm the long term operation effects on SCC. Based on test results, blade/rotor design and material selection guidelines to prevent SCC were established. Principles to prevent SCC in nuclear turbines are: 1) using clean rotor materials with less inclusions or impurities, 2) using lower yield strength materials, and 3) reducing stresses. These requirements are achieved by the full integral or welded rotor design with integral shroud LP end blade design. Nuclear steam turbines applying these technologies have been operating without any SCC problems for more than 20 years. This paper presents the outline of SCC free solutions and review the SCC problems of nuclear steam turbines at present. (authors)

  3. Estimating free-energy barrier heights for an ultrafast folding protein from calorimetric and kinetic data.

    Science.gov (United States)

    Godoy-Ruiz, Raquel; Henry, Eric R; Kubelka, Jan; Hofrichter, James; Muñoz, Victor; Sanchez-Ruiz, Jose M; Eaton, William A

    2008-05-15

    Differential scanning calorimetry was used to measure the temperature dependence of the absolute heat capacity of the 35-residue subdomain of the villin headpiece, a protein that folds in 5 mus and is therefore assumed to have a small free-energy barrier separating folded and unfolded states. To obtain an estimate of the barrier height from the calorimetric data, two models, a variable-barrier model and an Ising-like model, were used to fit the heat capacity in excess of the folded state over the temperature range 15-125 degrees C. The variable-barrier model is based on an empirical mathematical form for the density of states, with four adjustable parameters and the enthalpy (H) as a reaction coordinate. The Ising-like model is based on the inter-residue contact map of the X-ray structure with exact enumeration of approximately 10(5) possible conformations, with two adjustable parameters in the partition function, and either the fraction of native contacts (Q) or the number of ordered residues (P) as reaction coordinates. The variable-barrier model provides an excellent fit to the data and yields a barrier height at the folding temperature ranging from 0.4 to 1.1 kcal mol(-1), while the Ising-like model provides a less good fit and yields barrier heights of 2.3 +/- 0.1 kcal mol(-1) and 2.1 +/- 0.1 kcal mol(-1) for the Q and P reaction coordinates, respectively. In both models, the barrier to folding increases with increasing temperature. Assuming a sufficiently large activation energy for diffusion on the free-energy surfaces, both models are consistent with the observation of a temperature-independent folding rate in previously published laser temperature-jump experiments. Analysis of this kinetic data, using an approximate form for the pre-exponential factor of Kramers theory and the 70 ns relaxation time for the fast phase that precedes the unfolding/refolding relaxation to determine the diffusion coefficient, results in a barrier height of 1.6 +/- 0.3 kcal mol

  4. Barriers to the free diffusion of proteins and lipids in the plasma membrane.

    Science.gov (United States)

    Trimble, William S; Grinstein, Sergio

    2015-02-01

    Biological membranes segregate into specialized functional domains of distinct composition, which can persist for the entire life of the cell. How separation of their lipid and (glyco)protein components is generated and maintained is not well understood, but the existence of diffusional barriers has been proposed. Remarkably, the physical nature of such barriers and the manner whereby they impede the free diffusion of molecules in the plane of the membrane has rarely been studied in depth. Moreover, alternative mechanisms capable of generating membrane inhomogeneity are often disregarded. Here we describe prototypical biological systems where membrane segregation has been amply documented and discuss the role of diffusional barriers and other processes in the generation and maintenance of their structural and functional compartmentalization.

  5. Adaptive trial designs: a review of barriers and opportunities

    Directory of Open Access Journals (Sweden)

    Kairalla John A

    2012-08-01

    Full Text Available Abstract Adaptive designs allow planned modifications based on data accumulating within a study. The promise of greater flexibility and efficiency stimulates increasing interest in adaptive designs from clinical, academic, and regulatory parties. When adaptive designs are used properly, efficiencies can include a smaller sample size, a more efficient treatment development process, and an increased chance of correctly answering the clinical question of interest. However, improper adaptations can lead to biased studies. A broad definition of adaptive designs allows for countless variations, which creates confusion as to the statistical validity and practical feasibility of many designs. Determining properties of a particular adaptive design requires careful consideration of the scientific context and statistical assumptions. We first review several adaptive designs that garner the most current interest. We focus on the design principles and research issues that lead to particular designs being appealing or unappealing in particular applications. We separately discuss exploratory and confirmatory stage designs in order to account for the differences in regulatory concerns. We include adaptive seamless designs, which combine stages in a unified approach. We also highlight a number of applied areas, such as comparative effectiveness research, that would benefit from the use of adaptive designs. Finally, we describe a number of current barriers and provide initial suggestions for overcoming them in order to promote wider use of appropriate adaptive designs. Given the breadth of the coverage all mathematical and most implementation details are omitted for the sake of brevity. However, the interested reader will find that we provide current references to focused reviews and original theoretical sources which lead to details of the current state of the art in theory and practice.

  6. Free energy barrier for melittin reorientation from a membrane-bound state to a transmembrane state

    CERN Document Server

    Irudayam, Sheeba J; Berkowitz, Max L

    2013-01-01

    An important step in a phospholipid membrane pore formation by melittin antimicrobial peptide is a reorientation of the peptide from a surface into a transmembrane conformation. In this work we perform umbrella sampling simulations to calculate the potential of mean force (PMF) for the reorientation of melittin from a surface-bound state to a transmembrane state and provide a molecular level insight into understanding peptide and lipid properties that influence the existence of the free energy barrier. The PMFs were calculated for a peptide to lipid (P/L) ratio of 1/128 and 4/128. We observe that the free energy barrier is reduced when the P/L ratio increased. In addition, we study the cooperative effect; specifically we investigate if the barrier is smaller for a second melittin reorientation, given that another neighboring melittin was already in the transmembrane state. We observe that indeed the barrier of the PMF curve is reduced in this case, thus confirming the presence of a cooperative effect.

  7. Barriers to Free Antiretroviral Treatment Access for Female Sex Workers in Chennai, India

    OpenAIRE

    Chakrapani, Venkatesan; Newman, Peter A.; Shunmugam, Murali; Kurian, Abraham K.; Dubrow, Robert

    2009-01-01

    India's National AIDS Control Organization (NACO) provides free first-line antiretroviral treatment (ART) at government centers for people living with HIV. To assist in developing policies and programs to ensure equity in ART access, we explored barriers to ART access among female sex workers (FSWs) living with HIV in Chennai. Between August and November 2007, we conducted three focus group discussions and two key informant interviews. Data were explored using framework analysis to identify c...

  8. Environmentally Design; Barriers and Challenges in the Integrated Design Process Approch

    DEFF Research Database (Denmark)

    Knudstrup, Mary-Ann

    heating. The paper will shortly present the method of the Integrated Design Process (IDP). It describes the background and means for developing a new method for designing integrated architecture in an interdisciplinary approach between architecture and engineering. It also describes the barriers and the...

  9. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2011-12-31

    This project (10/01/2010-9/30/2013), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This proposal will directly support the technical goals specified in DE-FOA-0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. We will develop novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; we will perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; we will perform material characterizations and oxidation/corrosion tests; and we will demonstrate our new Thermal barrier coating (TBC) systems experimentally under Integrated gasification combined cycle (IGCC) environments. The durability of the coating will be examined using the proposed High Temperature/High Pressure Durability Test Rig under real syngas product compositions.

  10. Lower-Temperature Invert Design For Diffusion Barrier

    International Nuclear Information System (INIS)

    The objective of this analysis is to advance the state of the subsurface facilities design to primarily support the ''Yucca Mountain Science and Engineering Report'' (DOE 2001) and to also support the preparation and revision of System Description Document's Section 2 system descriptions (CRWMS M and O 2001, pp. 9 and 11). The results may also eventually support the License Application (CRWMS M and O 2001, p. 3). The Performance Assessment Department will be the primary user of the information generated and will be used in abstraction modeling for the lower-temperature scenario (CRWMS M and O 200 1, p. 27). This analysis will evaluate the invert relative to the lower- and higher-temperature conditions in accordance with the primary tasks below. Invert design is a major factor in allowing water entering the drift to pass freely and enter the drift floor without surface ponding and in limiting diffusive transport into the host rock. Specific cost effective designs will be conceptualized under the new lower-temperature conditions in this analysis. Interfacing activities and all aspects of Integrated Safety Management and Nuclear Culture principles are included in this work scope by adhering to the respective principles during this design activity and by incorporating safety into the design analysis (CRWMS M and O 2001, p. 8). Primary tasks of this analysis include identifying available design information from existing sources on the invert as a diffusive barrier, developing concepts that reduce the amount steel, and developing other design features that accommodate both lower- and higher-temperature operating modes (CRWMS M and O 2001, p.16)

  11. CITY TRANSPORT IN BARRIER-FREE ARCHITECTURAL PLANNING SPACE FOR PEOPLE WITH LIMITED MOBILITY

    Directory of Open Access Journals (Sweden)

    Pryadko Igor’ Petrovich

    2014-09-01

    Full Text Available This paper reviews the current state of transport organization for people with limited mobility. The article evaluates the results of the actions the executive authorities of Moscow and Moscow Region take. Barrier-free space organization for disabled people and parents with prams is given a special attention. The lack of strategy in the sphere leads to considerable difficulties for people with limited ability. This problem should be solved in cooperation with the survey of other peoples' needs. The article gives examples of comfortable urban space in Sochi, Moscow, Chita, Mytishchi and analyses the ways urbanism influences people with limited abilities.

  12. How and Why To Free All Refereed Research From Access- and Impact-Barriers Online, Now

    CERN Document Server

    Harnad, S; Brody, T

    2001-01-01

    Researchers publish their findings in order to make an impact on research, not in order to sell their words. Access-tolls are barriers to research impact. Authors can now free their refereed research papers from all access tolls immediately by self-archiving them on-line in their own institution's Eprint Archives. Free eprints.org software creates Archives compliant with the Open Archives Initiative metadata-tagging Protocol OAI 1.0. These distributed institutional Archives are interoperable and can hence be harvested into global "virtual" archives, citation-linked and freely navigable by all. Self-archiving should enhance research productivity and impact as well as providing powerful new ways of monitoring and measuring it.

  13. Coarse-grained molecular dynamics study of membrane fusion: Curvature effects on free energy barriers along the stalk mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Kawamoto, Shuhei; Shinoda, Wataru, E-mail: w.shinoda@apchem.nagoya-u.ac.jp [Department of Applied Chemistry, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8603 (Japan); Klein, Michael L. [Institute for Computational Molecular Science, Temple University, SERC Building 1925 North 12th Street, Philadelphia, Pennsylvania 19122 (United States)

    2015-12-28

    The effects of membrane curvature on the free energy barrier for membrane fusion have been investigated using coarse-grained molecular dynamics (CG-MD) simulations, assuming that fusion takes place through a stalk intermediate. Free energy barriers were estimated for stalk formation as well as for fusion pore formation using the guiding potential method. Specifically, the three different geometries of two apposed membranes were considered: vesicle–vesicle, vesicle–planar, and planar–planar membranes. The free energy barriers for the resulting fusion were found to depend importantly on the fusing membrane geometries; the lowest barrier was obtained for vesicular membranes. Further, lipid sorting was observed in fusion of the mixed membranes of dimyristoyl phosphatidylcholine and dioleoyl phosphatidylethanolamine (DOPE). Specifically, DOPE molecules were found to assemble around the stalk to support the highly negative curved membrane surface. A consistent result for lipid sorting was observed when a simple continuum model (CM) was used, where the Helfrich energy and mixing entropy of the lipids were taken into account. However, the CM predicts a much higher free energy barrier than found using CG-MD. This discrepancy originates from the conformational changes of lipids, which were not considered in the CM. The results of the CG-MD simulations reveal that a large conformational change in the lipid takes place around the stalk region, which results in a reduction of free energy barriers along the stalk mechanism of membrane fusion.

  14. Coarse-grained molecular dynamics study of membrane fusion: Curvature effects on free energy barriers along the stalk mechanism

    International Nuclear Information System (INIS)

    The effects of membrane curvature on the free energy barrier for membrane fusion have been investigated using coarse-grained molecular dynamics (CG-MD) simulations, assuming that fusion takes place through a stalk intermediate. Free energy barriers were estimated for stalk formation as well as for fusion pore formation using the guiding potential method. Specifically, the three different geometries of two apposed membranes were considered: vesicle–vesicle, vesicle–planar, and planar–planar membranes. The free energy barriers for the resulting fusion were found to depend importantly on the fusing membrane geometries; the lowest barrier was obtained for vesicular membranes. Further, lipid sorting was observed in fusion of the mixed membranes of dimyristoyl phosphatidylcholine and dioleoyl phosphatidylethanolamine (DOPE). Specifically, DOPE molecules were found to assemble around the stalk to support the highly negative curved membrane surface. A consistent result for lipid sorting was observed when a simple continuum model (CM) was used, where the Helfrich energy and mixing entropy of the lipids were taken into account. However, the CM predicts a much higher free energy barrier than found using CG-MD. This discrepancy originates from the conformational changes of lipids, which were not considered in the CM. The results of the CG-MD simulations reveal that a large conformational change in the lipid takes place around the stalk region, which results in a reduction of free energy barriers along the stalk mechanism of membrane fusion

  15. Random free energy barrier hopping model for ac conduction in chalcogenide glasses

    Science.gov (United States)

    Murti, Ram; Tripathi, S. K.; Goyal, Navdeep; Prakash, Satya

    2016-03-01

    The random free energy barrier hopping model is proposed to explain the ac conductivity (σac) of chalcogenide glasses. The Coulomb correlation is consistently accounted for in the polarizability and defect distribution functions and the relaxation time is augmented to include the overlapping of hopping particle wave functions. It is observed that ac and dc conduction in chalcogenides are due to same mechanism and Meyer-Neldel (MN) rule is the consequence of temperature dependence of hopping barriers. The exponential parameter s is calculated and it is found that s is subjected to sample preparation and measurement conditions and its value can be less than or greater than one. The calculated results for a - Se, As2S3, As2Se3 and As2Te3 are found in close agreement with the experimental data. The bipolaron and single polaron hopping contributions dominates at lower and higher temperatures respectively and in addition to high energy optical phonons, low energy optical and high energy acoustic phonons also contribute to the hopping process. The variations of hopping distance with temperature is also studied. The estimated defect number density and static barrier heights are compared with other existing calculations.

  16. Barriers to free antiretroviral treatment access for female sex workers in Chennai, India.

    Science.gov (United States)

    Chakrapani, Venkatesan; Newman, Peter A; Shunmugam, Murali; Kurian, Abraham K; Dubrow, Robert

    2009-11-01

    India's National AIDS Control Organization (NACO) provides free first-line antiretroviral treatment (ART) at government centers for people living with HIV. To assist in developing policies and programs to ensure equity in ART access, we explored barriers to ART access among female sex workers (FSWs) living with HIV in Chennai. Between August and November 2007, we conducted three focus group discussions and two key informant interviews. Data were explored using framework analysis to identify categories and derive themes. We found interrelated barriers at the family/social, health care system/programmatic, and individual levels. Major barriers included fear of adverse consequences of disclosure of HIV status due to stigma and discrimination associated with HIV and sex work, lack of family support, negative experiences with health care providers, lack of adequate counseling services at government centers and by outreach workers employed by nongovernmental organizations (NGOs), perceived biased treatment of FSWs who are not referred by NGOs, lack of adequate knowledge about ART, and fatalism. Barriers can be addressed by: creating effective measures to reduce stigma associated with HIV/AIDS and sex work at the familial, societal, and health care system levels; incorporating information about ART into targeted interventions among FSWs; training counselors at government hospitals and NGO outreach workers on treatment issues; improving infrastructure and staffing levels at government centers to allow adequate time and privacy for counseling; and implementing government mass media campaigns on ART availability. Finally, it is crucial that NACO begin monitoring ART coverage of FSWs and other marginalized populations to ensure equitable ART access. PMID:19821725

  17. Barrier properties of nano silicon carbide designed chitosan nanocomposites.

    Science.gov (United States)

    Pradhan, Gopal C; Dash, Satyabrata; Swain, Sarat K

    2015-12-10

    Nano silicon carbide (SiC) designed chitosan nanocomposites were prepared by solution technique. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) were used for studying structural interaction of nano silicon carbide (SiC) with chitosan. The morphology of chitosan/SiC nanocomposites was investigated by field emission scanning electron microscope (FESEM), and high resolution transmission electron microscope (HRTEM). The thermal stability of chitosan was substantially increased due to incorporation of stable silicon carbide nanopowder. The oxygen permeability of chitosan/SiC nanocomposites was reduced by three folds as compared to the virgin chitosan. The chemical resistance properties of chitosan were enhanced due to the incorporation of nano SiC. The biodegradability was investigated using sludge water. The tensile strength of chitosan/SiC nanocomposites was increased with increasing percentage of SiC. The substantial reduction in oxygen barrier properties in combination with increased thermal stability, tensile strength and chemical resistance properties; the synthesized nanocomposite may be suitable for packaging applications.

  18. Analysis and experimental study on formation conditions of large-scale barrier-free diffuse atmospheric pressure air plasmas in repetitive pulse mode

    Science.gov (United States)

    Li, Lee; Liu, Lun; Liu, Yun-Long; Bin, Yu; Ge, Ya-Feng; Lin, Fo-Chang

    2014-01-01

    Atmospheric air diffuse plasmas have enormous application potential in various fields of science and technology. Without dielectric barrier, generating large-scale air diffuse plasmas is always a challenging issue. This paper discusses and analyses the formation mechanism of cold homogenous plasma. It is proposed that generating stable diffuse atmospheric plasmas in open air should meet the three conditions: high transient power with low average power, excitation in low average E-field with locally high E-field region, and multiple overlapping electron avalanches. Accordingly, an experimental configuration of generating large-scale barrier-free diffuse air plasmas is designed. Based on runaway electron theory, a low duty-ratio, high voltage repetitive nanosecond pulse generator is chosen as a discharge excitation source. Using the wire-electrodes with small curvature radius, the gaps with highly non-uniform E-field are structured. Experimental results show that the volume-scaleable, barrier-free, homogeneous air non-thermal plasmas have been obtained between the gap spacing with the copper-wire electrodes. The area of air cold plasmas has been up to hundreds of square centimeters. The proposed formation conditions of large-scale barrier-free diffuse air plasmas are proved to be reasonable and feasible.

  19. Smoke-free homes: what are the barriers, motivators and enablers? A qualitative systematic review and thematic synthesis

    Science.gov (United States)

    Robinson, Jude; Wiggers, John

    2016-01-01

    Objective To thematically synthesise primary qualitative studies of the barriers, motivators and enablers of smoke-free homes (SFHs). Design Systematic review and thematic synthesis. Data sources Searches of MEDLINE, EBM Reviews (Cochrane Database of Systematic Reviews), PsycINFO, Global Health, CINAHL, Web of Science, Informit and EMBASE, combining terms for families, households and vulnerable populations; SFH and secondhand smoke; and qualitative research, were supplemented by searches of PhD theses, key authors, specialist journals and reference lists. Study selection We included 22 articles, reporting on 18 studies, involving 646 participants. Inclusion criteria: peer-reviewed; English language; published from 1990 onwards (to week 3 of April 2014); used qualitative data collection methods; explored participants’ perspectives of home smoking behaviours; and the barriers, motivators and enablers to initiating and/or maintaining a SFH. Data extraction 1 of 3 authors extracted data with checking by a second. Data synthesis A thematic synthesis was performed to develop 7 core analytic themes: (1) knowledge, awareness and risk perception; (2) agency and personal skills/attributes; (3) wider community norms and personal moral responsibilities; (4) social relationships and influence of others; (5) perceived benefits, preferences and priorities; (6) addiction and habit; (7) practicalities. Conclusions This synthesis highlights the complexity faced by many households in having a SFH, the practical, social, cultural and personal issues that need to be addressed and balanced by households, and that while some of these are common across study settings, specific social and cultural factors play a critical role in shaping household smoking behaviours. The findings can inform policy and practice and the development of interventions aimed at increasing SFHs. Trial registration number CRD42014014115. PMID:26988351

  20. Optimization Design Model of Functional Gradient Thermal Barrier Coating Material by Using Parallel Computation

    Directory of Open Access Journals (Sweden)

    Chen Zhao

    2016-01-01

    Full Text Available It is important for huge ship to find the ceramic/metal functional gradient thermal barrier coating materials. A parallel computation model is built for optimization design of three-dimensional ceramic/metal functionally gradient thermal barrier coating material. According to the control equation and initial-boundary conditions, the heat transfer problem is considered, and numerical algorithms of optimization design is constructed by adapting difference method. The numerical results shows that gradient thermal barrier coating material can improve the function of material.

  1. Molecular origin of high free energy barriers for alkali metal ion transfer through ionic liquid-graphene electrode interfaces.

    Science.gov (United States)

    Ivaništšev, Vladislav; Méndez-Morales, Trinidad; Lynden-Bell, Ruth M; Cabeza, Oscar; Gallego, Luis J; Varela, Luis M; Fedorov, Maxim V

    2016-01-14

    In this work we study mechanisms of solvent-mediated ion interactions with charged surfaces in ionic liquids by molecular dynamics simulations, in an attempt to reveal the main trends that determine ion-electrode interactions in ionic liquids. We compare the interfacial behaviour of Li(+) and K(+) at a charged graphene sheet in a room temperature ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate, and its mixtures with lithium and potassium tetrafluoroborate salts. Our results show that there are dense interfacial solvation structures in these electrolytes that lead to the formation of high free energy barriers for these alkali metal cations between the bulk and direct contact with the negatively charged surface. We show that the stronger solvation of Li(+) in the ionic liquid leads to the formation of significantly higher interfacial free energy barriers for Li(+) than for K(+). The high free energy barriers observed in our simulations can explain the generally high interfacial resistance in electrochemical storage devices that use ionic liquid-based electrolytes. Overcoming these barriers is the rate-limiting step in the interfacial transport of alkali metal ions and, hence, appears to be a major drawback for a generalised application of ionic liquids in electrochemistry. Some plausible strategies for future theoretical and experimental work for tuning them are suggested.

  2. Molecular origin of high free energy barriers for alkali metal ion transfer through ionic liquid-graphene electrode interfaces.

    Science.gov (United States)

    Ivaništšev, Vladislav; Méndez-Morales, Trinidad; Lynden-Bell, Ruth M; Cabeza, Oscar; Gallego, Luis J; Varela, Luis M; Fedorov, Maxim V

    2016-01-14

    In this work we study mechanisms of solvent-mediated ion interactions with charged surfaces in ionic liquids by molecular dynamics simulations, in an attempt to reveal the main trends that determine ion-electrode interactions in ionic liquids. We compare the interfacial behaviour of Li(+) and K(+) at a charged graphene sheet in a room temperature ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate, and its mixtures with lithium and potassium tetrafluoroborate salts. Our results show that there are dense interfacial solvation structures in these electrolytes that lead to the formation of high free energy barriers for these alkali metal cations between the bulk and direct contact with the negatively charged surface. We show that the stronger solvation of Li(+) in the ionic liquid leads to the formation of significantly higher interfacial free energy barriers for Li(+) than for K(+). The high free energy barriers observed in our simulations can explain the generally high interfacial resistance in electrochemical storage devices that use ionic liquid-based electrolytes. Overcoming these barriers is the rate-limiting step in the interfacial transport of alkali metal ions and, hence, appears to be a major drawback for a generalised application of ionic liquids in electrochemistry. Some plausible strategies for future theoretical and experimental work for tuning them are suggested. PMID:26661060

  3. Resonator design for a visible wavelength free-electron laser [*

    International Nuclear Information System (INIS)

    Design requirements for a visible wavelength free-electron laser being developed at the Accelerator Test Facility at Brookhaven National Laboratory are presented along with predictions of laser performance from 3-D numerical simulations. The design and construction of the optical resonator, its alignment and control systems are also described. 15 refs., 8 figs., 4 tabs

  4. When Free Is Not for Me: Confronting the Barriers to Use of Free Quitline Telephone Counseling for Tobacco Dependence

    Directory of Open Access Journals (Sweden)

    Christine Sheffer

    2015-12-01

    Full Text Available Remarkable disparities in smoking rates in the United States contribute significantly to socioeconomic and minority health disparities. Access to treatment for tobacco use can help address these disparities, but quitlines, our most ubiquitous treatment resource, reach just 1%–2% of smokers. We used community-based participatory methods to develop a survey instrument to assess barriers to use of the quitline in the Arkansas Mississippi delta. Barriers were quitline specific and barriers to cessation more broadly. Over one-third (34.9% of respondents (n = 799 did not have access to a telephone that they could use for the quitline. Respondents reported low levels of knowledge about the quitline, quitting, and trust in tobacco treatment programs as well as considerable ambivalence about quitting including significant concerns about getting sick if they quit and strong faith-based beliefs about quitting. These findings suggest quitlines are not accessible to all lower socioeconomic groups and that significant barriers to use include barriers to cessation. These findings suggest targets for providing accessible tobacco use treatment services and addressing concerns about cessation among lower income, ethnic minority, and rural groups.

  5. A Matrix-Free Algorithm for Multidisciplinary Design Optimization

    Science.gov (United States)

    Lambe, Andrew Borean

    Multidisciplinary design optimization (MDO) is an approach to engineering design that exploits the coupling between components or knowledge disciplines in a complex system to improve the final product. In aircraft design, MDO methods can be used to simultaneously design the outer shape of the aircraft and the internal structure, taking into account the complex interaction between the aerodynamic forces and the structural flexibility. Efficient strategies are needed to solve such design optimization problems and guarantee convergence to an optimal design. This work begins with a comprehensive review of MDO problem formulations and solution algorithms. First, a fundamental MDO problem formulation is defined from which other formulations may be obtained through simple transformations. Using these fundamental problem formulations, decomposition methods from the literature are reviewed and classified. All MDO methods are presented in a unified mathematical notation to facilitate greater understanding. In addition, a novel set of diagrams, called extended design structure matrices, are used to simultaneously visualize both data communication and process flow between the many software components of each method. For aerostructural design optimization, modern decomposition-based MDO methods cannot efficiently handle the tight coupling between the aerodynamic and structural states. This fact motivates the exploration of methods that can reduce the computational cost. A particular structure in the direct and adjoint methods for gradient computation. motivates the idea of a matrix-free optimization method. A simple matrix-free optimizer is developed based on the augmented Lagrangian algorithm. This new matrix-free optimizer is tested on two structural optimization problems and one aerostructural optimization problem. The results indicate that the matrix-free optimizer is able to efficiently solve structural and multidisciplinary design problems with thousands of variables and

  6. 城市无障碍设施浅论%Discussion About City Barrier-free Facilities

    Institute of Scientific and Technical Information of China (English)

    石冰; 于东

    2011-01-01

    According to the problems analysis of the actuality and construction of barrier-free facilities,this paper enlarges the definition of traditional barrier-free facilities,puts forward reasonable and perfect suggestions from the aspects of humanity and economy technique.%通过对我国无障碍设施建设的现状及建设中存在问题的分析,从而对传统的无障碍设施定义进行了扩展;并针对无障碍设施中存在的问题,着重从人文关怀及经济技术两方面提出了较合理完善的建议。

  7. Assessment as a Barrier in Developing Design Expertise: Interior Design Student Perceptions of Meanings and Sources of Grades

    Science.gov (United States)

    Smith, Kennon M.

    2013-01-01

    This article reports on a portion of a larger qualitative study focused on a group of interior design students' perceptions of their educational experiences. Twelve interior design students enrolled in their final studio course participated in interviews intended to elicit their perceptions of key barriers encountered during their…

  8. Spanning Knowledge Barriers in E-Learning Content Design

    Science.gov (United States)

    Chu, Tsai-Hsin; Lee, Yi; Lee, Yen-Hsien

    2013-01-01

    E-learning content development can be regarded as an example of knowledge delivery process because the developers have to receive knowledge transferred from subject-matter experts (SMEs), to translate the received knowledge with appropriate instructional design, and to transform the project outcomes to fulfill learner's learning needs. As…

  9. Development of a design package for a viscous barrier at the Savannah River Site

    International Nuclear Information System (INIS)

    This paper describes elements of a design for a pilot-scale field demonstration of a new subsurface containment technology for waste isolation developed at the Lawrence Berkeley National Laboratory (LBNL), which uses a new generation of barrier liquids for permeation grouting. The demonstration site was Retention Basin 281-3H, a shallow catchment basin at the Savannah River Site (SRS), originally built to control contaminated runoff for the H Reactor, and which has been contaminated mainly by radionuclides. The LBNL viscous barrier technology employs barrier liquids which, when injected into the subsurface, produce chemically benign nearly impermeable barriers through a very large increase in viscosity. The initially low-viscosity liquids are emplaced through multiple injection points in the subsurface and the intersecting plumes merge and completely surround the contaminant source and/or plume. Once in place, they gel or cure to form a nearly impermeable barrier. The barrier liquid to be used in this application is Colloidal Silica (CS), an aqueous suspension of silica microspheres in a stabilizing electrolyte. It has excellent durability characteristics, poses no health hazard, is practically unaffected by filtration, and is chemically and biologically benign

  10. Drawing a Roadmap: Barriers and Challenges to Designing the Ideal Virtual World for Higher Education

    Science.gov (United States)

    Johnson, Chris

    2008-01-01

    The goal of this article is to draw a roadmap for designing an "ideal" virtual world for higher education, pointing decision-makers in a general direction for implementing virtual worlds and noting various barriers along the way. When using a roadmap, one can take many different paths to reach a desired destination. Similarly, institutions can…

  11. Altered free radical metabolism in acute mountain sickness: implications for dynamic cerebral autoregulation and blood-brain barrier function

    DEFF Research Database (Denmark)

    Bailey, D M; Evans, K A; James, P E;

    2008-01-01

    We tested the hypothesis that dynamic cerebral autoregulation (CA) and blood-brain barrier (BBB) function would be compromised in acute mountain sickness (AMS) subsequent to a hypoxia-mediated alteration in systemic free radical metabolism. Eighteen male lowlanders were examined in normoxia (21% O...... developed clinical AMS (AMS+) and were more hypoxaemic relative to subjects without AMS (AMS-). A more marked increase in the venous concentration of the ascorbate radical (A(*-)), lipid hydroperoxides (LOOH) and increased susceptibility of low-density lipoprotein (LDL) to oxidation was observed during...

  12. Structural design of Stirling engine with free pistons

    Science.gov (United States)

    Matusov, Jozef; Gavlas, Stanislav; Malcho, Milan

    2014-08-01

    Stirling engine is a device that converts thermal energy to mechanical work, which is mostly used to drive a generator of electricity. Advantage of Stirling engine is that it works with closed-cycle, where working medium is regularly cooled and heated, which acts on the working piston. This engine can be made in three modifications - alpha, beta, gamma. This paper discusses the design of the gamma Stirling engine with free pistons.

  13. Design of active temperature compensated composite free-free beam MEMS resonators in a standard process

    Science.gov (United States)

    Xereas, George; Chodavarapu, Vamsy P.

    2014-03-01

    Frequency references are used in almost every modern electronic device including mobile phones, personal computers, and scientific and medical instrumentation. With modern consumer mobile devices imposing stringent requirements of low cost, low complexity, compact system integration and low power consumption, there has been significant interest to develop batch-manufactured MEMS resonators. An important challenge for MEMS resonators is to match the frequency and temperature stability of quartz resonators. We present 1MHz and 20MHz temperature compensated Free-Free beam MEMS resonators developed using PolyMUMPS, which is a commercial multi-user process available from MEMSCAP. We introduce a novel temperature compensation technique that enables high frequency stability over a wide temperature range. We used three strategies: passive compensation by using a structural gold (Au) layer on the resonator, active compensation through using a heater element, and a Free-Free beam design that minimizes the effects of thermal mismatch between the vibrating structure and the substrate. Detailed electro-mechanical simulations were performed to evaluate the frequency response and Quality Factor (Q). Specifically, for the 20MHz device, a Q of 10,000 was obtained for the passive compensated design. Finite Element Modeling (FEM) simulations were used to evaluate the Temperature Coefficient of frequency (TCf) of the resonators between -50°C and 125°C which yielded +0.638 ppm/°C for the active compensated, compared to -1.66 ppm/°C for the passively compensated design and -8.48 ppm/°C for uncompensated design for the 20MHz device. Electro-thermo-mechanical simulations showed that the heater element was capable of increasing the temperature of the resonators by approximately 53°C with an applied voltage of 10V and power consumption of 8.42 mW.

  14. Engineered Barrier Systems (EBS) in the safety case: design confirmation and demonstration

    International Nuclear Information System (INIS)

    The presence of several barriers serving complementary safety functions enhances confidence that radioactive waste placed in deep geological repositories will be adequately isolated and contained to protect human health and the environment. The barriers include the natural geological barrier and the engineered barrier system (EBS). The EBS itself may comprise a variety of sub-systems or components, such as the waste form, container, buffer, backfill, seals and plugs. Given the importance of this subject, the Integration Group for the Safety Case (IGSC) of the OECD Nuclear Energy Agency (NEA) sponsored a series of workshops with the European Commission to develop greater understanding of how to achieve the necessary integration for the successful design, testing, modelling and performance assessment of EBS for deep underground disposal of radioactive waste. These proceedings present the main findings from, and the papers delivered at, the fourth NEA-EC workshop on EBS, which took place in Tokyo, Japan, in September 2006. This final workshop of the series focused on strategies and methods to demonstrate that EBS designs will fulfill the relevant requirements for long-term safety, engineering feasibility and quality assurance. The workshop highlighted that large-scale experiments have confirmed the feasibility of techniques for manufacturing and installing engineered components in disposal systems and have also provided valuable lessons to improve designs and refine practical aspects to construct and implement EBS. (author)

  15. Diffusive Barrier and Getter Under Waste Packages VA Reference Design Feature Evaluations

    Energy Technology Data Exchange (ETDEWEB)

    MacNeil, K.

    1999-05-24

    This technical document evaluates those aspects of the diffusive barrier and getter features which have the potential for enhancing the performance of the Viability Assessment Reference Design and are also directly related to the key attributes for the repository safety strategy of that design. The effects of advection, hydrodynamic dispersion, and diffusion on the radionuclide migration rates through the diffusive barrier were determined through the application of the one-dimensional, advection/dispersion/diffusion equation. The results showed that because advective flow described by the advection-dispersion equation dominates, the diffusive barrier feature alone would not be effective in retarding migration of radiocuclides. However, if the diffusive barrier were combined with one or more features that reduced the potential for advection, then transport of radionuclides would be dominated by diffusion and their migration from the EBS would be impeded. Apatite was chosen as the getter material used for this report. Two getter configurations were developed, Case 1 and Case 2. As in the evaluation of the diffusive barrier, the effects of advection, hydrodynamic dispersion, and diffusion on the migration of radionuclides through the getter are evaluated. However, in addition to these mechanisms, the one-dimensional advection/dispersion/diffusion model is modified to include the effect of sorption on radionuclide migration rates through the sorptive medium (getter). As a result of sorption, the longitudinal dispersion coefficient, and the average linear velocity are effectively reduced by the retardation factor. The retardation factor is a function of the getter material's dry bulk density, sorption coefficient and moisture content. The results of the evaluation showed that a significant delay in breakthrough through the getter can be achieved if the thickness of the getter barrier is increased.

  16. Geotechnical, Hydrogeologic and Vegetation Data Package for 200-UW-1 Waste Site Engineered Surface Barrier Design

    Energy Technology Data Exchange (ETDEWEB)

    Ward, Andy L.

    2007-11-26

    Fluor Hanford (FH) is designing and assessing the performance of engineered barriers for final closure of 200-UW-1 waste sites. Engineered barriers must minimize the intrusion and water, plants and animals into the underlying waste to provide protection for human health and the environment. The Pacific Northwest National Laboratory (PNNL) developed Subsurface Transport Over Multiple Phases (STOMP) simulator is being used to optimize the performance of candidate barriers. Simulating barrier performance involves computation of mass and energy transfer within a soil-atmosphere-vegetation continuum and requires a variety of input parameters, some of which are more readily available than others. Required input includes parameter values for the geotechnical, physical, hydraulic, and thermal properties of the materials comprising the barrier and the structural fill on which it will be constructed as well as parameters to allow simulation of plant effects. This report provides a data package of the required parameters as well as the technical basis, rationale and methodology used to obtain the parameter values.

  17. The free energy barrier for arginine gating charge translation is altered by mutations in the voltage sensor domain.

    Directory of Open Access Journals (Sweden)

    Christine S Schwaiger

    Full Text Available The gating of voltage-gated ion channels is controlled by the arginine-rich S4 helix of the voltage-sensor domain moving in response to an external potential. Recent studies have suggested that S4 moves in three to four steps to open the conducting pore, thus visiting several intermediate conformations during gating. However, the exact conformational changes are not known in detail. For instance, it has been suggested that there is a local rotation in the helix corresponding to short segments of a 3(10-helix moving along S4 during opening and closing. Here, we have explored the energetics of the transition between the fully open state (based on the X-ray structure and the first intermediate state towards channel closing (C1, modeled from experimental constraints. We show that conformations within 3 Å of the X-ray structure are obtained in simulations starting from the C1 model, and directly observe the previously suggested sliding 3(10-helix region in S4. Through systematic free energy calculations, we show that the C1 state is a stable intermediate conformation and determine free energy profiles for moving between the states without constraints. Mutations indicate several residues in a narrow hydrophobic band in the voltage sensor contribute to the barrier between the open and C1 states, with F233 in the S2 helix having the largest influence. Substitution for smaller amino acids reduces the transition cost, while introduction of a larger ring increases it, largely confirming experimental activation shift results. There is a systematic correlation between the local aromatic ring rotation, the arginine barrier crossing, and the corresponding relative free energy. In particular, it appears to be more advantageous for the F233 side chain to rotate towards the extracellular side when arginines cross the hydrophobic region.

  18. Fast printing of thin, large area, ITO free electrochromics on flexible barrier foil

    DEFF Research Database (Denmark)

    Søndergaard, Roar R.; Hösel, Markus; Jørgensen, Mikkel;

    2013-01-01

    Processing of large area, indium tin oxide (ITO) free electrochromic (EC) devices has been carried out using roll-toroll (R2R) processing. By use of very fine high-conductive silver grids with a hexagonal structure, it is possible to achieve good transparency of the electrode covered substrates...

  19. The ASEAN Free Trade Agreement: Impact on Trade Flows and External Trade Barriers

    OpenAIRE

    Calvo-Pardo, Hector; Freund, Caroline; Ornelas, Emanuel

    2009-01-01

    Using detailed data on trade and tariffs from 1992-2007, the authors examine how the ASEAN Free Trade Agreement has affected trade with nonmembers and external tariffs facing nonmembers. First, the paper examines the effect of preferential and external tariff reduction on import growth from ASEAN insiders and outsiders across HS 6-digit industries. The analysis finds no evidence that prefe...

  20. Design of barrier coatings on kink-resistant peripheral nerve conduits.

    Science.gov (United States)

    Clements, Basak Acan; Bushman, Jared; Murthy, N Sanjeeva; Ezra, Mindy; Pastore, Christopher M; Kohn, Joachim

    2016-01-01

    Here, we report on the design of braided peripheral nerve conduits with barrier coatings. Braiding of extruded polymer fibers generates nerve conduits with excellent mechanical properties, high flexibility, and significant kink-resistance. However, braiding also results in variable levels of porosity in the conduit wall, which can lead to the infiltration of fibrous tissue into the interior of the conduit. This problem can be controlled by the application of secondary barrier coatings. Using a critical size defect in a rat sciatic nerve model, the importance of controlling the porosity of the nerve conduit walls was explored. Braided conduits without barrier coatings allowed cellular infiltration that limited nerve recovery. Several types of secondary barrier coatings were tested in animal studies, including (1) electrospinning a layer of polymer fibers onto the surface of the conduit and (2) coating the conduit with a cross-linked hyaluronic acid-based hydrogel. Sixteen weeks after implantation, hyaluronic acid-coated conduits had higher axonal density, displayed higher muscle weight, and better electrophysiological signal recovery than uncoated conduits or conduits having an electrospun layer of polymer fibers. This study indicates that braiding is a promising method of fabrication to improve the mechanical properties of peripheral nerve conduits and demonstrates the need to control the porosity of the conduit wall to optimize functional nerve recovery.

  1. Free energy barrier for melittin reorientation from a membrane-bound state to a transmembrane state

    OpenAIRE

    Irudayam, Sheeba J.; Pobandt, Tobias; Berkowitz, Max L.

    2013-01-01

    An important step in a phospholipid membrane pore formation by melittin antimicrobial peptide is a reorientation of the peptide from a surface into a transmembrane conformation. In this work we perform umbrella sampling simulations to calculate the potential of mean force (PMF) for the reorientation of melittin from a surface-bound state to a transmembrane state and provide a molecular level insight into understanding peptide and lipid properties that influence the existence of the free energ...

  2. Engineered barrier system and waste package design concepts for a potential geologic repository at Yucca Mountain

    Energy Technology Data Exchange (ETDEWEB)

    Short, D.W.; Ruffner, D.J.; Jardine, L.J.

    1991-10-01

    We are using an iterative process to develop preliminary concept descriptions for the Engineered Barrier System and waste-package components for the potential geologic repository at Yucca Mountain. The process allows multiple design concepts to be developed subject to major constraints, requirements, and assumptions. Involved in the highly interactive and interdependent steps of the process are technical specialists in engineering, metallic and nonmetallic materials, chemistry, geomechanics, hydrology, and geochemistry. We have developed preliminary design concepts that satisfy both technical and nontechnical (e.g., programmatic or policy) requirements.

  3. Ultraviolet Free Electron Laser Facility preliminary design report

    International Nuclear Information System (INIS)

    This document, the Preliminary Design Report (PDR) for the Brookhaven Ultraviolet Free Electron Laser (UV FEL) facility, describes all the elements of a facility proposed to meet the needs of a research community which requires ultraviolet sources not currently available as laboratory based lasers. Further, for these experiments, the requisite properties are not extant in either the existing second or upcoming third generation synchrotron light sources. This document is the result of our effort at BNL to identify potential users, determine the requirements of their experiments, and to design a facility which can not only satisfy the existing need, but have adequate flexibility for possible future extensions as need dictates and as evolving technology allows. The PDR is comprised of three volumes. In this, the first volume, background for the development of the proposal is given, including descriptions of the UV FEL facility, and representative examples of the science it was designed to perform. Discussion of the limitations and potential directions for growth are also included. A detailed description of the facility design is then provided, which addresses the accelerator, optical, and experimental systems. Information regarding the conventional construction for the facility is contained in an addendum to volume one (IA)

  4. Ultraviolet Free Electron Laser Facility preliminary design report

    Energy Technology Data Exchange (ETDEWEB)

    Ben-Zvi, I. (ed.)

    1993-02-01

    This document, the Preliminary Design Report (PDR) for the Brookhaven Ultraviolet Free Electron Laser (UV FEL) facility, describes all the elements of a facility proposed to meet the needs of a research community which requires ultraviolet sources not currently available as laboratory based lasers. Further, for these experiments, the requisite properties are not extant in either the existing second or upcoming third generation synchrotron light sources. This document is the result of our effort at BNL to identify potential users, determine the requirements of their experiments, and to design a facility which can not only satisfy the existing need, but have adequate flexibility for possible future extensions as need dictates and as evolving technology allows. The PDR is comprised of three volumes. In this, the first volume, background for the development of the proposal is given, including descriptions of the UV FEL facility, and representative examples of the science it was designed to perform. Discussion of the limitations and potential directions for growth are also included. A detailed description of the facility design is then provided, which addresses the accelerator, optical, and experimental systems. Information regarding the conventional construction for the facility is contained in an addendum to volume one (IA).

  5. Design and efficiency of stone dust barriers in modern Australian coal mines: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, B.; O`Beirne, T.; Australian Coal Industry Research Labs. Ltd., Sydney, NSW (Australia); SIMTARS

    1996-01-01

    This report focuses on explosibility conditions in the modern underground coal mine, the behaviour of explosions across the range of development from initiating gas ignitions to violent dust detonations and the effectiveness of current designs of passive explosion barriers to suppress the flame front. The principles of stone dusting and barrier operation, their effectiveness and limits of operation, based on full scale tests and incident reports, are presented. Current Australian stone dusting regulations include small safety margins in cases of very strong ignition energies. The report discusses increasing the levels, possibly to the United States requirements. The report concludes that good stone dusting practice is a more controllable and reliable strategy than using any other methods to suppress flames. However, as current dusting levels are considered to be marginal under some circumstances, it would be prudent to increase these levels if dusting was to be relied upon exclusively. Continuous miner headings are considered to be high ignition risk zones in a modern longwall, as there is potential for substantial pressure piling in the confined face area that could lead to a powerful dust ignition and a rapidly developing dust explosion. It is therefore proposed that the use of small triggered and active barriers, specifically designed to be fitted to cutting machines, should be evaluated. (author). Tabs., figs., refs.

  6. Blood-Brain Barrier Disruption and Oxidative Stress in Guinea Pig after Systemic Exposure to Modified Cell-Free Hemoglobin

    Science.gov (United States)

    Butt, Omer I.; Buehler, Paul W.; D'Agnillo, Felice

    2011-01-01

    Systemic exposure to cell-free hemoglobin (Hb) or its breakdown products after hemolysis or with the use of Hb-based oxygen therapeutics may alter the function and integrity of the blood-brain barrier. Using a guinea pig exchange transfusion model, we investigated the effect of a polymerized cell-free Hb (HbG) on the expression of endothelial tight junction proteins (zonula occludens 1, claudin-5, and occludin), astrocyte activation, IgG extravasation, heme oxygenase (HO), iron deposition, oxidative end products (4-hydroxynonenal adducts and 8-hydroxydeoxyguanosine), and apoptosis (cleaved caspase 3). Reduced zonula occludens 1 expression was observed after HbG transfusion as evidenced by Western blot and confocal microscopy. Claudin-5 distribution was altered in small- to medium-sized vessels. However, total expression of claudin-5 and occludin remained unchanged except for a notable increase in occludin 72 hours after HbG transfusion. HbG-transfused animals also showed increased astrocytic glial fibrillary acidic protein expression and IgG extravasation after 72 hours. Increased HO activity and HO-1 expression with prominent enhancement of HO-1 immunoreactivity in CD163-expressing perivascular cells and infiltrating monocytes/macrophages were also observed. Consistent with oxidative stress, HbG increased iron deposition, 4-hydroxynonenal and 8-hydroxydeoxyguanosine immunoreactivity, and cleaved caspase-3 expression. Systemic exposure to an extracellular Hb triggers blood-brain barrier disruption and oxidative stress, which may have important implications for the use of Hb-based therapeutics and may provide indirect insight on the central nervous system vasculopathies associated with excessive hemolysis. PMID:21356382

  7. Experimental design for demonstration of bio-barriers placed in a simulated burial trench

    International Nuclear Information System (INIS)

    Studies which have been undertaken to improve burial techniques to prevent the intrusion of buried wastes by plants and animals are described. The study consists of two parts. The first part is a demonstration trench in which a layer of cobble has been placed over simulated wastes and covered with a deep layer of topsoil. The second part is an experiment in which several different kinds of biological barriers are tested in a replicated plot design. The ''simulated wastes'' consist of soil mixed with lithium chloride, which is biologically available and can be easily detected by spectrophotometric analysis. The purpose of the study is to evaluate the effectiveness of these barriers to biological invasion of buried wastes

  8. Environmental Barrier Coatings for Turbine Engines: A Design and Performance Perspective

    Science.gov (United States)

    Zhu, Dongming; Fox, Dennis S.; Ghosn, Louis; Smialek, James L.; Miller, Robert A.

    2009-01-01

    Ceramic thermal and environmental barrier coatings (TEBC) for SiC-based ceramics will play an increasingly important role in future gas turbine engines because of their ability to effectively protect the engine components and further raise engine temperatures. However, the coating long-term durability remains a major concern with the ever-increasing temperature, strength and stability requirements in engine high heat-flux combustion environments, especially for highly-loaded rotating turbine components. Advanced TEBC systems, including nano-composite based HfO2-aluminosilicate and rare earth silicate coatings are being developed and tested for higher temperature capable SiC/SiC ceramic matrix composite (CMC) turbine blade applications. This paper will emphasize coating composite and multilayer design approach and the resulting performance and durability in simulated engine high heat-flux, high stress and high pressure combustion environments. The advances in the environmental barrier coating development showed promise for future rotating CMC blade applications.

  9. Barriers to Co-Designing Mobile Technology with Persons with Dementia and Their Carers.

    Science.gov (United States)

    O'Connor, Siobhan; Bouamrane, Matt-Mouley; O'Donnell, Catherine A; Mair, Frances S

    2016-01-01

    Mobile applications can be used to help manage different aspects of long-term illnesses but many are not designed to meet the specific needs of people with dementia or their carers. This case study explores the barriers experienced when co-producing a memory and reminiscence app. A focus group and interviews were conducted with patient/carer dyads, an occupational therapist, project manager and software engineer involved in the design of the app. Data was analysed thematically using the framework approach. Several limitations such as poor technical knowledge and skills, negative attitudes and inaccurate perceptions of people with dementia slowed down or changed how the mobile app was developed. Compromises also had to be made over the final design of the app. More research to explore how mobile apps are co-designed with patients is needed. PMID:27332466

  10. Conceptual design of industrial free electron laser using superconducting accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Saldin, E.L.; Schneidmiller, E.A.; Ulyanov, Yu.N. [Automatic Systems Corporation, Samara (Russian Federation)] [and others

    1995-12-31

    Paper presents conceptual design of free electron laser (FEL) complex for industrial applications. The FEL complex consists of three. FEL oscillators with the optical output spanning the infrared (IR) and ultraviolet (UV) wave-lengths ({lambda} = 0.3...20 {mu}m) and with the average output power 10 - 20 kW. The driving beam for the FELs is produced by a superconducting accelerator. The electron beam is transported to the FELs via three beam lines (125 MeV and 2 x 250 MeV). Peculiar feature of the proposed complex is a high efficiency of the. FEL oscillators, up to 20 %. This becomes possible due to the use of quasi-continuous electron beam and the use of the time-dependent undulator tapering.

  11. Functionalization of Hydrogen-free Diamond-like Carbon Films using Open-air Dielectric Barrier Discharge Atmospheric Plasma Treatments

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Instituto de Materiales de Madrid, C.S.I.C., Cantoblanco, 28049 Madrid, Spain; Instituto de Quimica-Fisica" Rocasolano" C.S.I.C., 28006 Madrid, Spain; Mahasarakham University, Mahasarakham 44150, Thailand; CASTI, CNR-INFM Regional Laboratory, L' Aquila 67100, Italy; SUNY Upstate Medical University, Syracuse, NY 13210, USA; Endrino, Jose; Endrino, J. L.; Marco, J. F.; Poolcharuansin, P.; Phani, A.R.; Allen, M.; Albella, J. M.; Anders, A.

    2007-12-28

    A dielectric barrier discharge (DBD) technique has been employed to produce uniform atmospheric plasmas of He and N2 gas mixtures in open air in order to functionalize the surface of filtered-arc deposited hydrogen-free diamond-like carbon (DLC) films. XPS measurements were carried out on both untreated and He/N2 DBD plasma treated DLC surfaces. Chemical states of the C 1s and N 1s peaks were collected and used to characterize the surface bonds. Contact angle measurements were also used to record the short- and long-term variations in wettability of treated and untreated DLC. In addition, cell viability tests were performed to determine the influence of various He/N2 atmospheric plasma treatments on the attachment of osteoblast MC3T3 cells. Current evidence shows the feasibility of atmospheric plasmas in producing long-lasting variations in the surface bonding and surface energy of hydrogen-free DLC and consequently the potential for this technique in the functionalization of DLC coated devices.

  12. Waste package/engineered barrier system design concepts for Yucca Mountain repository

    International Nuclear Information System (INIS)

    The U.S. Department of Energy (DOE) is responsible for the siting, construction and operation of mined geologic disposal system (MGDS) for high level waste. The U.S. Nuclear Regulatory Commission (NRC) has the responsibility for promulgating the technical requirements necessary to license all phases of repository operation. The development of MGDS has been delegated to the DOE's Yucca Mountain Site Characterization Project Office. The B ampersand W Fuel Company, as part of the Civilian Radioactive Waste Management System Management and Operating Contractor, is responsible for designing the waste package (WP) and the engineered barrier system (EBS). The goal of the design effort is to achieve a conservative, licensable design that meets the regulatory requirements with sufficient margin for uncertainty. Attainment of this goal relies on a multibarrier approach, the unsaturated nature of the Yucca Mountain site, consideration of, technical alternatives, and sufficient resolution of technical and regulatory uncertainties

  13. Design of an x-ray free electron laser undulator

    International Nuclear Information System (INIS)

    An undulator designed to be used for an x-ray free electron laser has to meet a set of stringent requirements. With no optical cavity, an x-ray FEL operates in the single pass Self Amplified Spontaneous Emission (SASE) mode; an electron macropulse is microbunched by an undulator and the radiation it creates. The microbunched pulse emits spontaneous radiation and coherent FEL radiation, whose power may reach saturation in a sufficiently long and perfect undulator. The pulse must have low emittance and high current, and its trajectory in the undulator must keep the radiation and the pulse together with a very high degree of overlap. We shall consider the case of the Linear Coherent Light Source (LCLS) FEL project at SLAC, which is intended to create 1.5 A x-rays using an electron beam with 15 GeV energy, 1.5π mm-mrad normalized emittance, 3400 A peak current, and 280 fsec FWHM bunch duration. We find that this 65 μm rms diameter beam must overlap its radiation with a walkoff of no more than 5 μm for efficient gain. This places severe limitations on the magnetic field errors and other mechanical tolerances. The following is a discussion of the undulator design, specifications, alignment, engineering, and beam position monitoring we plan to implement for the LCLS X-ray FEL

  14. Design of an x-ray free electron laser undulator

    International Nuclear Information System (INIS)

    An undulator designed to be used for an x-ray free electron laser has to meet a set of stringent requirements. With no optical cavity, an x-ray FeL operates in the single pass Self Amplified Spontaneous Emission (SASE) mode; an electron macropulse is microbunched by an undulator and the radiation it creates. The microbunched pulse emits spontaneous radiation and coherent FEL radiation, whose power may reach saturation in a sufficiently long and perfect undulator. The pulse must have low emittance and high current, and its trajectory in the undulator must keep the radiation and the pulse together with a very high degree of overlap. The authors shall consider the case of the Linear Coherent Light Source (LCLS) FEL project at SLAC, which is intended to create 1.5 angstrom x-rays using an electron beam with 15 GeV energy, 1.5π mm-mrad normalized emittance, 3,400 A peak current, and 280 fsec FWHM bunch duration. They find that this 65 microm rms diameter beam must overlap its radiation with a walkfoff of no more than 5 microm for efficient gain. This places severe limitations on the magnetic field errors and other mechanical tolerances. The following is a discussion of the undulator design, specifications, alignment, engineering, and beam position monitoring they plan to implement for the LCLS X-ray FEL

  15. Development Strategies on Barrier-free Facility Integration of City Public Transportation System%城市公共交通无障碍设施一体化实施对策研究

    Institute of Scientific and Technical Information of China (English)

    严亚丹; 过秀成

    2011-01-01

    Barrier-free construction of a public transportation system is an embodiment of human-oriented,transit priority policies and the requirement for promoting city grade.The relationship between the public transportation system and sustainable mobility was explored.The paper proposed a definition and the service objects of public transport barrier-free construction.Then,according to the existed problems in the process of accessibility construction of the public transportation system,the development strategies and measures from the perspectives of facility,design and management on barrier-free facility integration were discussed.%公共交通无障碍设施的建设是以人为本、公交优先的具体体现,亦是城市功能和品质提升的必然要求。论文探讨了公共交通与可持续机动性的关系,并在分析公共交通无障碍建设的服务对象和内涵的基础上,针对我国城市公共交通无障碍设施的建设现状,从设施配置、工程设计、运营管理等方面提出公共交通无障碍设施一体化的实施对策。

  16. Evaluating the long-term hydrology of an evapotranspiration-capillary barrier with a 1000 year design life

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Z. F.

    2016-06-25

    A surface barrier (or cover) is a commonly used technology for subsurface remediation. A key function of the barrier is to reduce or eliminate the movement of meteoric precipitation into the underlying waste zone, where it could mobilize and transport contaminants. Surface barriers are expected to perform for centuries to millennia, yet there are very few examples of performance for periods longer than a decade. The Prototype Hanford Barrier was constructed in 1994 over an existing waste site to demonstrate its long-term performance for a design period of 1000 years. This barrier is a field-scale evapotranspiration-capillary (ETC) barrier. In this design, the storage layer consists of 2-m-thick silt loam. The 19-year monitoring results show that the store-and-release mechanism for the ETC barrier worked efficiently as the storage layer was recharged in the winter season (November to March) and the stored water was released to the atmosphere in the summer season (April to October) via soil evaporation and plant transpiration. The capillary break functioned normally in improving the storage capacity and minimizing drainage. The maximum drainage observed through the ET barrier at any of the monitoring stations was only 0.178 mm yr-1 (under an enhanced precipitation condition), which is less than the design criterion. A very small amount (2.0 mm yr-1 on average) of runoff was observed during the 19-year monitoring period. The observed storage capacity of the storage layer was considerably (39%) larger than the estimated value based on the method of equilibrium of water pressure. After a controlled fire in 2008, the newly grown vegetation (primarily shallow-rooted grasses) could still release the stored water and summer precipitation to the atmosphere via transpiration. The findings are useful for predicting water storage and ET under different precipitation conditions and for the design of future barriers.

  17. 北京市无障碍建设法规执行状况调研%Investigation on the Implementation of Barrier-free Regulations in Beijing

    Institute of Scientific and Technical Information of China (English)

    安天义; 邓晓梅

    2011-01-01

    近年来我国的无障碍环境立法工作取得了瞩目的成绩,但也暴露出众多无障碍法规缺乏执行力的问题,限制了无障碍环境建设工作的落实和推广.本文关注于无障碍法规的执行力问题,以国内首部无障碍设施的地方性法规--为基准,对公共设施的无障碍建设情况开展实地调研.调研发现:以商业类设施和地铁类设施为代表的新建建筑比老建筑的无障碍建设情况要好;坡道、盲道、升降装置等设施的建设情况要明显好于警示标识、安全扶手、低位装置等设施;中的条款不够细致和全面,造成了在建设和验收环节没有明确的执行标准;而盲道被不合理占用等情况暴露出公众无障碍意识和知识缺乏的问题.本文的研究结果为无障碍法规的监督与执行提供了重要参考.%While the significant achievements have been obtained in respect of legislative work on barrier-free facilities, there are still problems with implementation of barrier-free regulations. This paper focuses on the implementation of Barrier-free regulations,and investigates the current situations of barrier-free environment of public buildings based on‘ The Regulation of Barrier-free Facilities Construction and Management in Beijing' , the first local regulation related to barrier-free in China. It is found that: ( 1 ) The barrierfree environment of new buildings, such as commercial buildings and subway facilities, is better than that of old buildings (2) Ramp way, blind walk way, barrier-free lift devices, and barrier-free lavatory are better built than warning sign, safety armrest, and lowposition devices; (3) The regulation is not comprehensive and explicit enough, which leads to no clear criteria to follow during construction and acceptance inspection; The misuse of blind walk way reveals that the public are lack of knowledge and awareness related to the barrier-free environment. The findings in this paper provide

  18. Deliberation of large noise barrier's design%大型声屏障设计研讨

    Institute of Scientific and Technical Information of China (English)

    刘秀莉; 郭吉坦

    2009-01-01

    运用有限元法对大型声屏障结构进行了静力学分析,并通过建模、结构设计、模型计算检验了大型声屏障的静力学性能,结果表明该大型声屏障结构的设计在静力学方面符合设计要求.%The paper makes statics analysis on large noise barrier by using finite dement method, it also inspects the statics ability of large noise harrier through mode establishing, structure design and mode calculating. The results show that structure design of large noise harder meets requirements of statics.

  19. Evaluating the long-term hydrology of an evapotranspiration-capillary barrier with a 1000 year design life

    Science.gov (United States)

    Zhang, Z. Fred

    2016-06-01

    A surface barrier is a commonly used technology for isolation of subsurface contaminants. Surface barriers for isolating radioactive waste are expected to perform for centuries to millennia, yet there are very few data for field-scale surface barriers for periods approaching a decade or longer. The Prototype Hanford Barrier (PHB) with a design life of 1000 years was constructed over an existing radioactive waste site in 1994 to demonstrate its long-term performance. The primary element of the PHB is an evapotranspiration-capillary (ETC) barrier in which precipitation water is stored in a fine-textured soil layer and later released to the atmosphere via evapotranspiration. To address the barrier performance under extreme conditions, this study included an enhanced precipitation stress test from 1995 to 1997 to determine barrier response to extreme precipitation events. During this period a 1000 year 24 h return rainstorm was simulated in March every year. The loss of vegetation on barrier hydrology was tested with a controlled fire test in 2008. The 19 year monitoring record shows that the store-and-release mechanism worked as well as or better than the design criterion. Average drainage from the ETC barrier amounted to an average of 0.005 mm yr-1, which is well below the design criterion of 0.5 mm yr-1. After a simulated wildfire, the naturally reestablished vegetation and increased evaporation combined to release the stored water and summer precipitation to the atmosphere such that drainage did not occur in the 5 years subsequent to the fire.

  20. Free Energy Barriers for the N-Terminal Asparagine to Succinimide Conversion: Quantum Molecular Dynamics Simulations for the Fully Solvated Model.

    Science.gov (United States)

    Kaliman, Ilya; Nemukhin, Alexander; Varfolomeev, Sergei

    2010-01-12

    Deamidation of asparagine residues represents one of the main routes for the post-translational modification of protein sequences. We computed the estimates of the free energy barriers for three stages of the deamidation process, deprotonation, cyclization, and deamination, of the conversion of asparagine to the succinimide intermediate within the fully solvated model with explicit water molecules. The Born-Oppenheimer molecular dynamics in the Gaussian and Plane Wave (GPW) approximation as implemented in the CP2K quantum chemistry package was utilized to sample the configurational space. By applying the metadynamics technique, the estimates of the free energy barriers were obtained for three separated stages of the reaction. In agreement with the experimental kinetic measurements, the estimated activation barriers do not exceed 21 kcal/mol. We demonstrate that the use of fully solvated models is the critical issue in theoretical studies of these reactions. We also conclude that more extensive sampling is necessary to obtain full free energy profiles and accurate barriers for the reaction stages. PMID:26614331

  1. Gravel admix, vegetation, and soil water interactions in protective barriers: Experimental design, construction, and initial conditions

    International Nuclear Information System (INIS)

    The purpose of this study is to measure the interactive effects of gravel admix and greater precipitation on soil water storage and plant abundance. The study is one of many tasks in the Protective Barrier Development Program for the disposal of Hanford defense waste. A factorial field-plot experiment was set up at the site selected as the borrow area for barrier topsoil. Gravel admix, vegetation, and enhanced precipitation treatments were randomly assigned to the plots using a split-split plot design structure. Changes in soil water storage and plant cover were monitored using neutron probe and point intercept methods, respectively. The first-year results suggest that water extraction by plants will offset gravel-caused increases in soil water storage. Near-surface soil water contents were much lower in graveled plots with plants than in nongraveled plots without plants. Large inherent variability in deep soil water storage masked any effects gravel may have had on water content below the root zone. In the future, this source of variation will be removed by differencing monthly data series and testing for changes in soil water storage. Tests of the effects of greater precipitation on soil water storage were inconclusive. A telling test will be possible in the spring of 1988, following the first wet season during which normal precipitation is doubled. 26 refs., 9 figs., 9 tabs

  2. Device physics and design of T-gate Schottky barrier tunnel FET with adaptive operation mechanism

    International Nuclear Information System (INIS)

    A T-shaped gate Schottky barrier tunnel FET (TSB-TFET) is discussed in detail and experimentally demonstrated with compatible bulk Si CMOS technology. The device can alleviate the major issues in traditional silicon TFET through adaptive operation mechanism, with higher ON-current from the dominant Schottky current, appreciably reduced off-leakage current from self-depletion effect, and steeper subthreshold slope (SS) from dominant band-to-band tunneling with enhanced source surface electric field through T-gate configuration. Without area penalty, the fabricated silicon-based device can achieve steeper SS over more than 4 decades of current and thus lower average SS, as well as higher ION/IOFF ratio of 106 compared with traditional TFET. The parameters for device design and analog circuit applications are studied as well. Simulation results show that TSB-TFET can achieve excellent on-off current trade-off by lowering the Schottky barrier height, and also demonstrate lower gate-to-drain capacitance and better analog parameters performance than traditional TFET. (paper)

  3. Impact of barrier thickness on transistor performance in AlN/GaN high electron mobility transistors grown on free-standing GaN substrates

    Energy Technology Data Exchange (ETDEWEB)

    Deen, David A., E-mail: david.deen@alumni.nd.edu; Storm, David F.; Meyer, David J.; Bass, Robert; Binari, Steven C. [Electronics Science and Technology Division, Naval Research Laboratory, Washington, DC 20375-5347 (United States); Gougousi, Theodosia [Physics Department, University of Maryland Baltimore County, Baltimore, Maryland 21250 (United States); Evans, Keith R. [Kyma Technologies, Raleigh, North Carolina 27617 (United States)

    2014-09-01

    A series of six ultrathin AlN/GaN heterostructures with varied AlN thicknesses from 1.5–6 nm have been grown by molecular beam epitaxy on free-standing hydride vapor phase epitaxy GaN substrates. High electron mobility transistors (HEMTs) were fabricated from the set in order to assess the impact of barrier thickness and homo-epitaxial growth on transistor performance. Room temperature Hall characteristics revealed mobility of 1700 cm{sup 2}/V s and sheet resistance of 130 Ω/□ for a 3 nm thick barrier, ranking amongst the lowest room-temperature sheet resistance values reported for a polarization-doped single heterostructure in the III-Nitride family. DC and small signal HEMT electrical characteristics from submicron gate length HEMTs further elucidated the effect of the AlN barrier thickness on device performance.

  4. Living with comfort in the Kelheim district. Energy efficient - safe - barrier-free; Wohnen mit Komfort im Landkreis Kelheim. Energieeffizient - sicher - barrierefrei

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-05-01

    In the future, the increasing costs of energy will shape the housing conditions more and more. A house should be built not only energy efficiently but also barrier-free. Under this aspect, the brochure under consideration provides information on the future planning of a building and on the alteration of the existing housing situation. Financial supports and offers of consultancy as well as energy consultants in the Kelheim district (Federal Republic of Germany) are presented.

  5. Barriers to free antiretroviral treatment access among kothi-identified men who have sex with men and aravanis (transgender women) in Chennai, India

    OpenAIRE

    Chakrapani, Venkatesan; Newman, Peter A.; Shunmugam, Murali; Dubrow, Robert

    2011-01-01

    The Indian government provides free antiretroviral treatment (ART) for people living with HIV. To assist in developing policies and programs to advance equity in ART access, we explored barriers to ART access among kothis (men who have sex with men whose gender expression is feminine) and aravanis (transgender women, also known as hijras) living with HIV in Chennai. In the last quarter of 2007, we conducted six focus groups and four key-informant interviews. Data were explored using framework...

  6. “Engelsiz Şehir” Kavramı Açısından Malatya (Malatya From The Perspective Of “Barrier-Free City” Concept

    Directory of Open Access Journals (Sweden)

    Gülizar ÇAKIR SÜMER

    2015-06-01

    Full Text Available Demand of barrier-free cities is a part of human rights and meeting of this demand is one of the main responsibility areas of administrations. Even it exists legal regulations on establishing barrier-free cities in Turkey, the problem is mostly about practice of these regulations. This study aims at exerting that the structure providing integration of the disabled to the city is inadequate on the ground of Malatya city center. To this end, it has been tried to be determined whether urban accesories, substructure, public buildings are appropriate or not for access of the disabled, and the present situation has been analysed from the perspective of "barrier-free city" concept. After the survey performed, in context of developing city planning perception, it has been determined that even there have been positive progress on eliminating the obstacles which are faced by the disabled at country life, problems and deficiencies still go on. In this sense, many of the buildings and services are far away from being accessible by the disabled.

  7. Application of "Barrier-free" Design in Packaging of Personal Care Products%“无障碍”设计在洗护品容器包装上的应用

    Institute of Scientific and Technical Information of China (English)

    刘春媛; 李国涛

    2011-01-01

    Through analyzing the idea of barrier-free design, combined with the container design of personal care, it discussed the embodiment of barrier-free design: just as convenient performance, appropriate psychological and emotional needs. It is an important part that packaging materials, structures, shape and color, texture and single or combinations of visual effects about personal care products. On this basis, it analyzed the development prospects of barrier-free design in the product packaging design and its application and development.%通过分析无障碍设计这一设计理念,并结合洗护品的容器设计论述了无障碍设计体现在便利的使用性能、适宜的心理和情感需求,论述了包装材料、结构、造型及其色彩、肌理及洗护品单体及其组合后的视觉效果是无障碍设计中的重要组成部分。在此基础上,进而分析了无障碍设计在洗护品包装中的发展前景,探讨无障碍设计在产品包装设计中的应用和发展。

  8. Design of dry barriers for containment of contaminants in unsaturated soils

    Energy Technology Data Exchange (ETDEWEB)

    Morris, C.E. [Univ. of Wollongong (Australia); Thomson, B.M.; Stormont, J.C. [Univ. of New Mexico, Albuquerque, NM (United States)

    1997-12-31

    A dry barrier is a region of very dry conditions in unsaturated soil that prevents vertical migration of water created by circulating dry air through the formation. Dry soil creates a barrier to vertical water movement by decreasing the soil`s hydraulic conductivity, a concept also used in capillary barriers. A dry barrier may be a viable method for providing containment of a contaminant plume in a setting with a thick unsaturated zone and dry climate. The principal factors which determine the feasibility of a dry barrier include: (1) an and environment, (2) thick vadose zone, and (3) the ability to circulate air through the vadose zone. This study investigated the technical and economic considerations associated with creating a dry barrier to provide containment of a hypothetical 1 ha aqueous contaminant plume. The concept appears to be competitive with other interim containment methods such as ground freezing.

  9. Design of dry barriers for containment of contaminants in unsaturated soils

    International Nuclear Information System (INIS)

    A dry barrier is a region of very dry conditions in unsaturated soil that prevents vertical migration of water created by circulating dry air through the formation. Dry soil creates a barrier to vertical water movement by decreasing the soil's hydraulic conductivity, a concept also used in capillary barriers. A dry barrier may be a viable method for providing containment of a contaminant plume in a setting with a thick unsaturated zone and dry climate. The principal factors which determine the feasibility of a dry barrier include: (1) an and environment, (2) thick vadose zone, and (3) the ability to circulate air through the vadose zone. This study investigated the technical and economic considerations associated with creating a dry barrier to provide containment of a hypothetical 1 ha aqueous contaminant plume. The concept appears to be competitive with other interim containment methods such as ground freezing

  10. Design and Performance Optimizations of Advanced Erosion-Resistant Low Conductivity Thermal Barrier Coatings for Rotorcraft Engines

    Science.gov (United States)

    Zhu, Dongming; Miller, Robert A.; Kuczmarski, Maria A.

    2012-01-01

    Thermal barrier coatings will be more aggressively designed to protect gas turbine engine hot-section components in order to meet future rotorcraft engine higher fuel efficiency and lower emission goals. For thermal barrier coatings designed for rotorcraft turbine airfoil applications, further improved erosion and impact resistance are crucial for engine performance and durability, because the rotorcraft are often operated in the most severe sand erosive environments. Advanced low thermal conductivity and erosion-resistant thermal barrier coatings are being developed, with the current emphasis being placed on thermal barrier coating toughness improvements using multicomponent alloying and processing optimization approaches. The performance of the advanced thermal barrier coatings has been evaluated in a high temperature erosion burner rig and a laser heat-flux rig to simulate engine erosion and thermal gradient environments. The results have shown that the coating composition and architecture optimizations can effectively improve the erosion and impact resistance of the coating systems, while maintaining low thermal conductivity and cyclic oxidation durability

  11. Barriers to free antiretroviral treatment access among kothi-identified men who have sex with men and aravanis (transgender women) in Chennai, India.

    Science.gov (United States)

    Chakrapani, Venkatesan; Newman, Peter A; Shunmugam, Murali; Dubrow, Robert

    2011-12-01

    The Indian government provides free antiretroviral treatment (ART) for people living with HIV. To assist in developing policies and programs to advance equity in ART access, we explored barriers to ART access among kothis (men who have sex with men [MSM] whose gender expression is feminine) and aravanis (transgender women, also known as hijras) living with HIV in Chennai. In the last quarter of 2007, we conducted six focus groups and four key-informant interviews. Data were explored using framework analysis to identify categories and derive themes. We identified barriers to ART access at the family/social-level, health care system-level, and individual-level; however, we found these barriers to be highly interrelated. The primary individual-level barrier was integrally linked to the family/social and health care levels: many kothis and aravanis feared serious adverse consequences if their HIV-positive status were revealed to others. Strong motivations to keep one's HIV-positive status and same-sex attraction secret were interconnected with sexual prejudice against MSM and transgenders, and HIV stigma prevalent in families, the health care system, and the larger society. HIV stigma was present within kothi and aravani communities as well. Consequences of disclosure, including rejection by family, eviction from home, social isolation, loss of subsistence income, and maltreatment (although improving) within the health care system, presented powerful disincentives to accessing ART. Given the multi-level barriers to ART access related to stigma and discrimination, interventions to facilitate ART uptake should address multiple constituencies: the general public, health care providers, and the kothi and aravani communities. India needs a national policy and action plan to address barriers to ART access at family/social, health care system, and individual levels for aravanis, kothis, other subgroups of MSM and other marginalized groups. PMID:22117127

  12. VLSI Design with Alliance Free CAD Tools: an Implementation Example

    Directory of Open Access Journals (Sweden)

    Chávez-Bracamontes Ramón

    2015-07-01

    Full Text Available This paper presents the methodology used for a digital integrated circuit design that implements the communication protocol known as Serial Peripheral Interface, using the Alliance CAD System. The aim of this paper is to show how the work of VLSI design can be done by graduate and undergraduate students with minimal resources and experience. The physical design was sent to be fabricated using the CMOS AMI C5 process that features 0.5 micrometer in transistor size, sponsored by the MOSIS Educational Program. Tests were made on a platform that transfers data from inertial sensor measurements to the designed SPI chip, which in turn sends the data back on a parallel bus to a common microcontroller. The results show the efficiency of the employed methodology in VLSI design, as well as the feasibility of ICs manufacturing from school projects that have insufficient or no source of funding

  13. pH homeostasis during coral calcification in a free ocean CO2 enrichment (FOCE) experiment, Heron Island reef flat, Great Barrier Reef.

    Science.gov (United States)

    Georgiou, Lucy; Falter, James; Trotter, Julie; Kline, David I; Holcomb, Michael; Dove, Sophie G; Hoegh-Guldberg, Ove; McCulloch, Malcolm

    2015-10-27

    Geochemical analyses (δ(11)B and Sr/Ca) are reported for the coral Porites cylindrica grown within a free ocean carbon enrichment (FOCE) experiment, conducted on the Heron Island reef flat (Great Barrier Reef) for a 6-mo period from June to early December 2010. The FOCE experiment was designed to simulate the effects of CO2-driven acidification predicted to occur by the end of this century (scenario RCP4.5) while simultaneously maintaining the exposure of corals to natural variations in their environment under in situ conditions. Analyses of skeletal growth (measured from extension rates and skeletal density) showed no systematic differences between low-pH FOCE treatments (ΔpH = ∼-0.05 to -0.25 units below ambient) and present day controls (ΔpH = 0) for calcification rates or the pH of the calcifying fluid (pHcf); the latter was derived from boron isotopic compositions (δ(11)B) of the coral skeleton. Furthermore, individual nubbins exhibited near constant δ(11)B compositions along their primary apical growth axes (±0.02 pHcf units) regardless of the season or treatment. Thus, under the highly dynamic conditions of the Heron Island reef flat, P. cylindrica up-regulated the pH of its calcifying fluid (pHcf ∼8.4-8.6), with each nubbin having near-constant pHcf values independent of the large natural seasonal fluctuations of the reef flat waters (pH ∼7.7 to ∼8.3) or the superimposed FOCE treatments. This newly discovered phenomenon of pH homeostasis during calcification indicates that coral living in highly dynamic environments exert strong physiological controls on the carbonate chemistry of their calcifying fluid, implying a high degree of resilience to ocean acidification within the investigated ranges.

  14. Rotordynamics and Design Methods of an Oil-Free Turbocharger

    Science.gov (United States)

    Howard, Samuel A.

    1999-01-01

    The feasibility of supporting a turbocharger rotor on air foil bearings is investigated based upon predicted rotordynamic stability, load accommodations, and stress considerations. It is demonstrated that foil bearings offer a plausible replacement for oil-lubricated bearings in diesel truck turbochargers. Also, two different rotor configurations are analyzed and the design is chosen which best optimizes the desired performance characteristics. The method of designing machinery for foil bearing use and the assumptions made are discussed.

  15. Polarization-balanced design of heterostructures: Application to AlN/GaN double-barrier structures

    Science.gov (United States)

    Berland, Kristian; Andersson, Thorvald G.; Hyldgaard, Per

    2011-12-01

    Inversion and depletion regions generally form at the interfaces between doped leads (cladding layers) and the active region of polar heterostructures like AlN/GaN and other nitride compounds. The band bending in the depletion region sets up a barrier that may seriously impede perpendicular electronic transport. This may ruin the performance of devices such as quantum-cascade lasers and resonant-tunneling diodes. Here we introduce the concepts of polarization balance and polarization-balanced designs: A structure is polarization balanced when the applied bias match the voltage drop arising from spontaneous and piezeolectric fields. Devices designed to operate at this bias have polarization-balanced designs. These concepts offer a systematic approach to avoid the formation of depletion regions. As a test case, we consider the design of AlN/GaN double-barrier structures with Alx˜Ga1-x˜N leads. To guide our efforts, we derive a simple relation between the intrinsic voltage drop arising from polar effects, average alloy composition of the active region, and the alloy concentration of the leads. Polarization-balanced designs secure good filling of the ground state for unbiased structures, while for biased structures with efficient emptying of the active region they remove the depletion barriers.

  16. System design considerations for free-fall materials processing

    Science.gov (United States)

    Seidensticker, R. G.

    1974-01-01

    The design constraints for orbiting materials processing systems are dominated by the limitations of the flight vehicle/crew and not by the processes themselves. Although weight, size and power consumption are all factors in the design of normal laboratory equipment, their importance is increased orders of magnitude when the equipment must be used in an orbital facility. As a result, equipment intended for space flight may have little resemblance to normal laboratory apparatus although the function to be performed may be identical. The same considerations influence the design of the experiment itself. The processing requirements must be carefully understood in terms of basic physical parameters rather than defined in terms of equipment operation. Preliminary experiments and analysis are much more vital to the design of a space experiment than they are on earth where iterative development is relatively easy. Examples of these various considerations are illustrated with examples from the M518 and MA-010 systems. While these are specific systems, the conclusions apply to the design of flight materials processing systems both present and future.

  17. Freeing the Serial Mechanism Designer from Inverse Kinematic Solvability Constraints

    Directory of Open Access Journals (Sweden)

    Diana C. W. Friedman

    2010-01-01

    Full Text Available This paper presents a fast numerical solution for the inverse kinematics of a serial manipulator. The method is implemented on the C-arm, a manipulator designed for use in robotic surgery. The inverse kinematics solution provides all possible solutions for any six degree-of-freedom serial manipulator, assuming that the forward kinematics are known and that it is possible to solve for the remaining joint angles if one joint angle’s value is known. With a fast numerical method and the current levels of computing power, designing a manipulator with closed-form inverse kinematics is no longer necessary. When designing the C-arm, we therefore chose to weigh other factors, such as actuator size and patient safety, more heavily than the ability to find a closed-form inverse kinematics solution.

  18. Modular design and the development of complex artifact lesson fron free open source software.

    OpenAIRE

    Alessandro Rossi; Alessandro Narduzzo

    2003-01-01

    Organizational and managerial theories of modularity applied to the design and production of complex artifacts are used to interpret the rise and success of Free/Open Source Software methodologies and practices in software engineering

  19. The design and implementation of the FreeBSD operating system

    CERN Document Server

    McKusick, Marshall Kirk; Watson, Robert N M

    2015-01-01

    The most complete, authoritative technical guide to the FreeBSD kernel's internal structure has now been extensively updated to cover all major improvements between Versions 5 and 11. Approximately one-third of this edition's content is completely new, and another one-third has been extensively rewritten. Three long-time FreeBSD project leaders begin with a concise overview of the FreeBSD kernel's current design and implementation. Next, they cover the FreeBSD kernel from the system-call level down-from the interface to the kernel to the hardware. Explaining key design decisions, they detail the concepts, data structures, and algorithms used in implementing each significant system facility, including process management, security, virtual memory, the I/O system, filesystems, socket IPC, and networking. This Second Edition * Explains highly scalable and lightweight virtualization using FreeBSD jails, and virtual-machine acceleration with Xen and Virtio device paravirtualization * Describes new security features...

  20. Low driving voltage in white organic light-emitting diodes using an interfacial energy barrier free multilayer emitting structure

    International Nuclear Information System (INIS)

    The driving voltage of white organic light-emitting diodes (WOLEDs) with blue fluorescent and red phosphorescent emitting materials was lowered by using a device architecture with little energy barrier between emitting layers. A mixed layer of hole and electron transport materials was used as a host material and an interlayer, reducing the driving voltage of WOLEDs. The driving voltage of WOLEDs was reduced by more than 4 V and power efficiency of WOLEDs was improved by more than 40% due to little energy barrier for holes and electrons injection in light-emitting layer. In addition, there was little change of electroluminescence spectra from 100 to 10,000 cd/m2.

  1. Friction material composites copper-metal-free material design perspective

    CERN Document Server

    Sundarkrishnaa, K L

    2015-01-01

    This book examines material composites used in connection with brake friction, their design and safety. To aid in understanding, the essentials of friction are explained. This second edition was extended to include friction material composites without copper, as they offer an environmentally friendlier option. The second edition is intended to support beginners by offering insights into the essentials of friction material composites, helping them to develop a broader understanding of brake friction materials. Friction materials find wide-ranging applications in household and industrial appliances, brake pads for automotive applications, rail brake friction pads and composition brake blocks. This second edition is an introductory volume to a set of related books, and is based on the author’s experience and expertise with various material manufacturers, brake manufacturers, vehicle manufacturers, researchers and testing labs around the world with which the author has been associated for the past 28 years.

  2. Design Challenges in High Power Free-Electron Laser Oscillators

    CERN Document Server

    Benson, S V

    2005-01-01

    Several FELs have now demonstrated high power lasing and several projects are under construction to deliver higher power or shorter wavelengths. This presentation will summarize progress in upgrading FEL oscillators towards higher power and will discuss some of the challenges these projects face. The challenges fall into three categories: 1. energy recovery with large exhaust energy spread, 2. output coupling and maintaining mirror figure in the presence of high intracavity power loading, and 3. high current operation in an energy recovery linac (ERL). Progress in all three of these areas has been made in the last year. Energy recovery of over 12% of exhaust energy spread has been demonstrated and designs capable of accepting even larger energy spreads have been proposed. Cryogenic transmissive output couplers for narrow band operation and both hole and scraper output coupling have been developed. Investigation of short Rayleigh range operation has started as well. Energy recovery of over 20 mA CW has been de...

  3. Development of a solvent-free analytical method for paracetamol quantitative determination in Blood Brain Barrier in vitro model.

    Science.gov (United States)

    Langlois, Marie-Hélène; Vekris, Antonios; Bousses, Christine; Mordelet, Elodie; Buhannic, Nathalie; Séguard, Céline; Couraud, Pierre-Olivier; Weksler, Babette B; Petry, Klaus G; Gaudin, Karen

    2015-04-15

    A Reversed Phase-High Performance Liquid Chromatography/Diode Array Detection method was developed and validated for paracetamol quantification in cell culture fluid from an in vitro Blood Brain Barrier model. The chromatographic method and sample preparation were developed using only aqueous solvents. The column was a XTerra RP18 150 × 4.6mm, 3.5 μm with a guard column XTerra RP18 20 × 4.6 mm, 3.5 μm at 35 °C and the mobile phase was composed by 100% formate buffer 20 mM at pH 4 and flow rate was set at 1 mL/min. The detection was at 242 nm. The sample was injected at 10 μL. Validation was performed using the accuracy profile approach. The analytical procedure was validated with the acceptance limits at ± 10% over a range of concentration from 1 to 58 mg L(-1). The procedure was then used in routine to determine paracetamol concentration in a brain blood barrier in vitro model. Application of the Unither paracetamol formulation in Blood Brain Barrier model allowed the determination and comparison of the transcellular passage of paracetamol at 37 °C and 4 °C, that excludes paracellular or non specific leakage.

  4. Decontamination systems information and research program -- Literature review in support of development of standard test protocols and barrier design models for in situ formed barriers project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-01

    The US Department of Energy is responsible for approximately 3,000 sites in which contaminants such as carbon tetrachloride, trichlorethylene, perchlorethylene, non-volatile and soluble organic and insoluble organics (PCBs and pesticides) are encountered. In specific areas of these sites radioactive contaminants are stored in underground storage tanks which were originally designed and constructed with a 30-year projected life. Many of these tanks are now 10 years beyond the design life and failures have occurred allowing the basic liquids (ph of 8 to 9) to leak into the unconsolidated soils below. Nearly one half of the storage tanks located at the Hanford Washington Reservation are suspected of leaking and contaminating the soils beneath them. The Hanford site is located in a semi-arid climate region with rainfall of less than 6 inches annually, and studies have indicated that very little of this water finds its way to the groundwater to move the water down gradient toward the Columbia River. This provides the government with time to develop a barrier system to prevent further contamination of the groundwater, and to develop and test remediation systems to stabilize or remove the contaminant materials. In parallel to remediation efforts, confinement and containment technologies are needed to retard or prevent the advancement of contamination plumes through the environment until the implementation of remediation technology efforts are completed. This project examines the various confinement and containment technologies and protocols for testing the materials in relation to their function in-situ.

  5. Decontamination systems information and research program -- Literature review in support of development of standard test protocols and barrier design models for in situ formed barriers project

    International Nuclear Information System (INIS)

    The US Department of Energy is responsible for approximately 3,000 sites in which contaminants such as carbon tetrachloride, trichlorethylene, perchlorethylene, non-volatile and soluble organic and insoluble organics (PCBs and pesticides) are encountered. In specific areas of these sites radioactive contaminants are stored in underground storage tanks which were originally designed and constructed with a 30-year projected life. Many of these tanks are now 10 years beyond the design life and failures have occurred allowing the basic liquids (ph of 8 to 9) to leak into the unconsolidated soils below. Nearly one half of the storage tanks located at the Hanford Washington Reservation are suspected of leaking and contaminating the soils beneath them. The Hanford site is located in a semi-arid climate region with rainfall of less than 6 inches annually, and studies have indicated that very little of this water finds its way to the groundwater to move the water down gradient toward the Columbia River. This provides the government with time to develop a barrier system to prevent further contamination of the groundwater, and to develop and test remediation systems to stabilize or remove the contaminant materials. In parallel to remediation efforts, confinement and containment technologies are needed to retard or prevent the advancement of contamination plumes through the environment until the implementation of remediation technology efforts are completed. This project examines the various confinement and containment technologies and protocols for testing the materials in relation to their function in-situ

  6. Local minima-free design of artificial coordinating fields

    Institute of Scientific and Technical Information of China (English)

    Xingjian JING; Yuechao WANG

    2004-01-01

    In order to overcome the drawbacks of conventional artificial potential fields (APF) based methods for the motion planning problems of mobile robots in dynamic uncertain environments,an artificial coordinating fields (ACF) based method has been proposed recently.This paper deals with the reachability problem of the ACF,that is,how to design and choose the parameters of the ACF and how the environment should be such that the robot can reach its goal without being trapped in local minima.Some sufficient conditions for these purposes are developed theoretically.Theoretical analyses show that,the ACF can effectively remove local minima in dynamic uncertain environments with V-shape or U-shape obstacles,and guide the mobile robot to reach its goal with some necessary environment constraints and based on the methods provided in this paper to properly choose the parameters of the ACF.Comparisons between the ACF and APF,and simulations are provided to illustrate the advantages of the ACF.

  7. On strength design using free material subjected to multiple load cases

    DEFF Research Database (Denmark)

    Pedersen, Pauli; Pedersen, Niels Leergaard

    2013-01-01

    with a practical recursive design procedure is presented and illustrated with examples. The presented finite element analysis involve many elements as well as many load cases. Separating the local amount of material from a description with unit trace for the local anisotropy, gives the free materials formulation......Multiple load cases and the consideration of strength is a reality that most structural designs are exposed to. Improved possibility to produce specific materials, say by fiber lay-up, put focus on research on free material optimization. A formulation for such design problems together...

  8. 上海轨道交通无障碍环境建设的再思考*%Rethinking Barrier Free Environment Construction in Shanghai Metro Transport

    Institute of Scientific and Technical Information of China (English)

    潘海啸; 邹为; 赵婷; 张仰斐

    2013-01-01

    The construction of the barrier free transport system has become a development trend of modern cities. Improving mobility of disabled people is an important responsibility of the city. At the same time, it can also improve the efficiency of travel for all citizens. Shanghai is now an aging society with high proportion senior citizens becoming disabled to travel. Mobility is a fundamental right of people; we must take effective response measures as early as possible to build a more livable city for all citizen. The concept for barrier free has been applied in Shanghai metro construction at early stage. Now handicapped people are much rely on metro to travel a long distance. But there are still some inconveniences for disabled people to use the system. This paper analyzes the background and problems in barrier free construction of Shanghai metro, pointing out the importance of shifting the concept from barrier free transport only for handicapped people to benefit al citizens. With the reference of international advanced concept and practice, some recommendations have been proposed on the reality of barrier free construction in Shanghai metro.%  城市无障碍交通体系的建设已经成为现代城市一种发展趋势。改善行动不方便者的交通出行是城市的一项重要责任,同时又可以提高城市运行的效率。已经进入老年社会的上海,因老致残的比例日益提高。交通出行是人们的一项基本权利,我们必须及早采取有效应对措施,建设一个更加宜居的城市。上海轨道交通无障碍环境建设起步早,已成为残疾人出行的重要交通工具,但也还存在一些不便之处。首先阐述了上海轨道交通无障碍环境建设的背景,分析存在的问题,指出在轨道交通无障碍环境建设中理念转变的重要性。通过对国际无障碍建设先进理念的分析,结合上海的实际情况,提出上海轨道交通无障碍建设的建议。

  9. Probabilistic design of the steel structure of the new waterway storm surge barrier

    NARCIS (Netherlands)

    Manen, S.E. van; Vrouwenvelder, A.C.W.M.; Foeken, R.J. van

    1996-01-01

    As part of the sea defence system along the Dutch coast, a storm surge barrier is under construction in the New Waterway, near Rotterdam. The Dutch Ministry of Public Works requires for this structure that the probability of failure is at most 10' per year (104 in life time of 100 years). This is al

  10. Efficacy of Elimination of Pasteurella pneumotropica from a Mouse Specific Pathogen-Free Barrier Breeding Unit through Treatment with Enrofloxacin

    DEFF Research Database (Denmark)

    Østergaard, Grete; Arnorsdottir, Stefania Embla; Schumacher-Petersen, Camilla;

    2010-01-01

    and administered in drinking water based on an assumed daily water intake of 150 mL/kg body weight. Prior to treatment, all imports of mice (caesarean section or embryo transfer) were stopped. The populations of the various mouse strains bred in the barrier were minimized. Measures were taken to ensure there would...... be no births or suckling young prior to—and during—the 2-wk treatment period with antibiotics. Following the 2-wk treatment period, series of 30 mice were screened every 3 mo, using the procedure described above. At the present point in time, 6 mo after seponation of the treatment, and following 2 screenings...

  11. The Design and Test of New Salt-Free Reagent Destruction Device

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Qian; OUYANG; Ying-gen; LI; Hui-bo

    2012-01-01

    <正>A new device which can destroy remnant salt-free reducing agent in 1BP or 2BP was designed. In current process the salt-free reagent destruction is: generally 1BP solution is slowly added into a sealed container containing a certain amount of concentrated nitric acid, connected to a vacuum pump, then placed in a protective flask. Because of corrosion of the nitrogen oxides in reaction, the rubber plug used

  12. Final design of a free-piston hydraulic advanced Stirling conversion system

    Science.gov (United States)

    Wallace, D. A.; Noble, J. E.; Emigh, S. G.; Ross, B. A.; Lehmann, G. A.

    1991-01-01

    Under the US Department of Energy's (DOEs) Solar Thermal Technology Program, Sandia National Laboratories is evaluating heat engines for solar distributed receiver systems. The final design is described of an engineering prototype advanced Stirling conversion system (ASCS) with a free-piston hydraulic engine output capable of delivering about 25 kW of electric power to a utility grid. The free-piston Stirling engine has the potential for a highly reliable engine with long life because it has only a few moving parts, has noncontacting bearings, and can be hermetically sealed. The ASCS is designed to deliver maximum power per year over a range of solar input with a design life of 30 years (60,000 h). The system includes a liquid Nak pool boiler heat transport system and a free-piston Stirling engine with high-pressure hydraulic output, coupled with a bent axis variable displacement hydraulic motor and a rotary induction generator.

  13. Final design of a free-piston hydraulic advanced Stirling conversion system

    Science.gov (United States)

    Wallace, D. A.; Noble, J. E.; Emigh, S. G.; Ross, B. A.; Lehmann, G. A.

    Under the US Department of Energy's (DOEs) Solar Thermal Technology Program, Sandia National Laboratories is evaluating heat engines for solar distributed receiver systems. The final design is described of an engineering prototype advanced Stirling conversion system (ASCS) with a free-piston hydraulic engine output capable of delivering about 25 kW of electric power to a utility grid. The free-piston Stirling engine has the potential for a highly reliable engine with long life because it has only a few moving parts, has noncontacting bearings, and can be hermetically sealed. The ASCS is designed to deliver maximum power per year over a range of solar input with a design life of 30 years (60,000 h). The system includes a liquid Nak pool boiler heat transport system and a free-piston Stirling engine with high-pressure hydraulic output, coupled with a bent axis variable displacement hydraulic motor and a rotary induction generator.

  14. New strategies and developments in transparent free-form design: From facetted to nearly smooth envelopes

    KAUST Repository

    Baldassini, Niccolo

    2009-09-01

    Free-form geometries in architecture pose new challenges to designers and engineers. Form, structure and fabrication processes are closely linked, which makes the realization of complex architectural free-form structures even harder. Free-form transparent design today is mainly based on triangularly facetted forms or quadrilateral meshes supported by a structure composed of rectilinear bars, with strong shape restrictions. After a brief review of the history, we report on some very recent progress in this area. Beginning with a presentation of improved methods for triangle mesh design, we also discuss experiences in coupling triangular glass panels with continuous curved structures, seeking an optimised structural behaviour and simplified connections. Furthermore, we present how the results of research on planar quadrilateral (PQ) meshes lead the way to optimized beam layouts and the breakdown of free-form shapes using planar quadrilateral panels. PQ meshes are rooted in discrete differential geometry, an active area of mathematical research. Using recent projects as examples, we discuss how transparent free-form envelopes with a smooth visual appearance are achievable if the structure is designed to adhere to the limits of current glazing technology and the surfaces are reasonably simple (e.g. rotational, overall developable, or of a small scale). In section 6 we show how the latter restriction can be relaxed: the theoretical and computational methodology for PQ meshes can easily be extended to create nearly smooth approximations of free-form surfaces by single-curved panels. This has a strong impact on glass panelling design, since it avoids expensive double-curvature glass and exploits cold-bending technology. We elaborate on how this discretisation technique goes hand in hand with the technology for construction of the structure, glazing system and structural joints. Our approach has been tested in three case studies, each one validating a particular aspect of

  15. Design of a scanning gate microscope in a cryogen-free dilution refrigerator

    CERN Document Server

    Pelliccione, Matthew; Bartel, John; Keller, Andrew; Goldhaber-Gordon, David

    2012-01-01

    We report on our design of a scanning gate microscope housed in a cryogen-free dilution refrigerator with a base temperature of 15 mK. The recent increase in efficiency of pulse tube cryocoolers has made cryogen-free systems popular in recent years. However, this new style of cryostat presents challenges for performing scanning probe measurements, mainly as a result of the vibrations introduced by the cryocooler. We demonstrate scanning with root-mean-square vibrations of 0.8 nm at 3 K and 2.1 nm at 15 mK in a 1 kHz bandwidth with our design.

  16. Design, Construction and Test of Cryogen-Free HTS Coil Structure

    Energy Technology Data Exchange (ETDEWEB)

    Hocker, H.; Anerella, M.; Gupta, R.; Plate, S.; Sampson, W.; Schmalzle, J.; Shiroyanagi, Y.

    2011-03-28

    This paper will describe design, construction and test results of a cryo-mechanical structure to study coils made with the second generation High Temperature Superconductor (HTS) for the Facility for Rare Isotope Beams (FRIB). A magnet comprised of HTS coils mounted in a vacuum vessel and conduction-cooled with Gifford-McMahon cycle cryocoolers is used to develop and refine design and construction techniques. The study of these techniques and their effect on operations provides a better understanding of the use of cryogen free magnets in future accelerator projects. A cryogen-free, superconducting HTS magnet possesses certain operational advantages over cryogenically cooled, low temperature superconducting magnets.

  17. Designed azurins show lower reorganization free energies for intraprotein electron transfer

    DEFF Research Database (Denmark)

    Farver, Ole; Marshall, Nicholas M; Wherland, Scot;

    2013-01-01

    Low reorganization free energies are necessary for fast electron transfer (ET) reactions. Hence, rational design of redox proteins with lower reorganization free energies has been a long-standing challenge, promising to yield a deeper understanding of the underlying principles of ET reactivity...... and to enable potential applications in different energy conversion systems. Herein we report studies of the intramolecular ET from pulse radiolytically produced disulfide radicals to Cu(II) in rationally designed azurin mutants. In these mutants, the copper coordination sphere has been fine-tuned to span...

  18. Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe?

    Science.gov (United States)

    2014-01-01

    Background Both active and passive tobacco smoke (TS) potentially impair the vascular endothelial function in a causative and dose-dependent manner, largely related to the content of reactive oxygen species (ROS), nicotine, and pro-inflammatory activity. Together these factors can compromise the restrictive properties of the blood–brain barrier (BBB) and trigger the pathogenesis/progression of several neurological disorders including silent cerebral infarction, stroke, multiple sclerosis and Alzheimer’s disease. Based on these premises, we analyzed and assessed the toxic impact of smoke extract from a range of tobacco products (with varying levels of nicotine) on brain microvascular endothelial cell line (hCMEC/D3), a well characterized human BBB model. Results Initial profiling of TS showed a significant release of reactive oxygen (ROS) and reactive nitrogen species (RNS) in full flavor, nicotine-free (NF, “reduced-exposure” brand) and ultralow nicotine products. This release correlated with increased oxidative cell damage. In parallel, membrane expression of endothelial tight junction proteins ZO-1 and occludin were significantly down-regulated suggesting the impairment of barrier function. Expression of VE-cadherin and claudin-5 were also increased by the ultralow or nicotine free tobacco smoke extract. TS extract from these cigarettes also induced an inflammatory response in BBB ECs as demonstrated by increased IL-6 and MMP-2 levels and up-regulation of vascular adhesion molecules, such as VCAM-1 and PECAM-1. Conclusions In summary, our results indicate that NF and ultralow nicotine cigarettes are potentially more harmful to the BBB endothelium than regular tobacco products. In addition, this study demonstrates that the TS-induced toxicity at BBB ECs is strongly correlated to the TAR and NO levels in the cigarettes rather than the nicotine content. PMID:24755281

  19. The study, design and simulation of a free piston Stirling engine linear alternatorThe study, design and simulation of a free piston Stirling engine linear alternator

    Directory of Open Access Journals (Sweden)

    Teodora Susana Oros

    2014-12-01

    Full Text Available This paper presents a study, design and simulation of a Free Piston Stirling Engine Linear Alternator. There are presented the main steps of the magnetic and electric calculations for a permanent magnet linear alternator of fixed coil and moving magnets type. Finally, a detailed thermal, mechanical and electrical model for a Stirling engine linear alternator have been made in SIMULINK simulation program. The linear alternator simulation model uses a controllable DC voltage which simulates the linear alternator combined with a rectifier, a variable load and a DC-DC converter, which compensates for the variable nature of Stirling engine operation, and ensures a constant voltage output regardless of the load.

  20. Design and analysis of a mode-hop-free tunable laser based on etched diffraction grating

    Institute of Scientific and Technical Information of China (English)

    Rui-xing ZENG; Lei WANG; Jian-jun HE

    2010-01-01

    A novel semiconductor laser which can achieve mode-hop-free tuning is proposed.The device consists of an etched diffraction grating(EDG)as a dispersive element to provide the mode selection function and an active waveguide to provide optical gain for the laser.The slab waveguide region of the EDG contains a tuning section covered by an electrode to inject a toning current,and thus changes the refractive index.Mode-hop-free tuning is achieved by specially designing the shape of the tuning section,so that the tuning rate of the central wavelength reflected by the EDG and the tuning rate of the resonant wavelength of the laser cavity are equal.An optimized tuning section shape is designed to obtain the largest tuning range within a limited current range.Numerical simulation is presented to demonstrate the mode-hop-free tuning operation.

  1. The prepuce free flap in 10 patients : modifications in flap design and surgical technique

    NARCIS (Netherlands)

    Werker, Paul M N

    2002-01-01

    The prepuce free flap was used in 10 oral and oropharyngeal reconstructions. During the course of this study, various modifications took place. Residual penile skin necrosis and skin island necrosis early in the series led to modification of flap design. This solved the donor-site problem by placing

  2. An Evaluation of a Group Project Designed to Reduce Free-Riding and Promote Active Learning

    Science.gov (United States)

    Swaray, Raymond

    2012-01-01

    Group projects are recognised as effective means of engaging students with work-related skills and promoting cooperative learning. This paper reports findings of a small survey--a group project designed to reduce problems associated with the process of production of group goods and services: free-riding and monitoring participation level. The…

  3. Design of free-form reflector for vehicle LED low-beam headlamp

    Science.gov (United States)

    Tsai, Chung-Yu

    2016-08-01

    A method is proposed for the design of a vehicle low-beam headlamp system comprising a reflector and an LED light source. In the proposed approach, the profile of the reflector is designed using a free-form (FF) surface construction method such that each incident ray is directed in such a way as to form a user-specified light pattern on the measuring plane. The light ray paths within the headlamp system are analyzed using an exact analytical model and a skew-ray tracing approach. The validity of the proposed FF design method is demonstrated by means of ZEMAX simulations. It is shown that the light pattern formed on the measuring plane is in good agreement with the target pattern specified by ECE R112. The FF design method is mathematically straightforward and easily implemented in computer code. As such, it provides a useful tool for the design and analysis tasks in optical systems design.

  4. A Simple Method for Assessing Free Brain/Free Plasma Ratios Using an In Vitro Model of the Blood Brain Barrier

    Science.gov (United States)

    Sevin, Emmanuel; Szorath, Erica; Martinsson, Stefan; Renftel, Mila; Hongmei, Yan; Cecchelli, Romeo; Lundquist, Stefan

    2013-01-01

    Historically, the focus has been to use in vitro BBB models to optimize rate of drug delivery to the CNS, whereas total in vivo brain/plasma ratios have been used for optimizing extent. However, these two parameters do not necessarily show good correlations with receptor occupancy data or other pharmacological readouts. In line with the free drug hypothesis, the use of unbound brain concentrations (Cu,br) has been shown to provide the best correlations with pharmacological data. However, typically the determination of this parameter requires microdialysis, a technique not ideally suited for screening in early drug development. Alternative, and less resource-demanding methodologies to determine Cu,br employ either equilibrium dialysis of brain homogenates or incubations of brain slices in buffer to determine fraction unbound brain (fu,br), which is subsequently multiplied by the total brain concentration to yield Cu,br. To determine Cu,br/Cu,pl ratios this way, still requires both in vitro and in vivo experiments that are quite time consuming. The main objective of this study was to explore the possibility to directly generate Cu,br/Cu,pl ratios in a single in vitro model of the BBB, using a co-culture of brain capillary endothelial and glial cells in an attempt to mimick the in vivo situation, thereby greatly simplifying existing experimental procedures. Comparison to microdialysis brain concentration profiles demonstrates the possibility to estimate brain exposure over time in the BBB model. A stronger correlation was found between in vitro Cu,br/Cu,pl ratios and in vivo Cu,br/Cu,pl obtained using fu,br from brain slice than with fu,br from brain homogenate for a set of 30 drugs. Overall, Cu,br/Cu,pl ratios were successfully predicted in vitro for 88% of the 92 studied compounds. This result supports the possibility to use this methodology for identifying compounds with a desirable in vivo response in the CNS early on in the drug discovery process. PMID:24312489

  5. Novel free-form hohlraum shape design and optimization for laser-driven inertial confinement fusion

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Shaoen; Jing, Longfei, E-mail: scmyking-2008@163.com; Ding, Yongkun [Laser Fusion Research Center, China Academy Engineering Physics, Mianyang 621900 (China); Huang, Yunbao, E-mail: huangyblhy@gmail.com [Mechatronics School of Guangdong University of Technology, Guangzhou 510006 (China)

    2014-10-15

    The hohlraum shape attracts considerable attention because there is no successful ignition method for laser-driven inertial confinement fusion at the National Ignition Facility. The available hohlraums are typically designed with simple conic curves, including ellipses, parabolas, arcs, or Lame curves, which allow only a few design parameters for the shape optimization, making it difficult to improve the performance, e.g., the energy coupling efficiency or radiation drive symmetry. A novel free-form hohlraum design and optimization approach based on the non-uniform rational basis spline (NURBS) model is proposed. In the present study, (1) all kinds of hohlraum shapes can be uniformly represented using NURBS, which is greatly beneficial for obtaining the optimal available hohlraum shapes, and (2) such free-form uniform representation enables us to obtain an optimal shape over a large design domain for the hohlraum with a more uniform radiation and higher drive temperature of the fuel capsule. Finally, a hohlraum is optimized and evaluated with respect to the drive temperature and symmetry at the Shenguang III laser facility in China. The drive temperature and symmetry results indicate that such a free-form representation is advantageous over available hohlraum shapes because it can substantially expand the shape design domain so as to obtain an optimal hohlraum with high performance.

  6. Design-with-Nature for Multifunctional Landscapes: Environmental Benefits and Social Barriers in Community Development

    OpenAIRE

    Yang, Bo; Li, Ming-Han; Li, Shujuan

    2013-01-01

    Since the early 1970s, Ian McHarg’s design-with-nature concept has been inspiring landscape architects, community and regional planners, and liked-minded professionals to create designs that take advantage of ecosystem services and promote environmental and public health. This study bridges the gap in the literature that has resulted from a lack of empirical examinations on the multiple performance benefits derived through design-with-nature and the under-investigated social aspect emanated f...

  7. Design-with-nature for multifunctional landscapes: environmental benefits and social barriers in community development.

    Science.gov (United States)

    Yang, Bo; Li, Ming-Han; Li, Shujuan

    2013-11-01

    Since the early 1970s, Ian McHarg's design-with-nature concept has been inspiring landscape architects, community and regional planners, and liked-minded professionals to create designs that take advantage of ecosystem services and promote environmental and public health. This study bridges the gap in the literature that has resulted from a lack of empirical examinations on the multiple performance benefits derived through design-with-nature and the under-investigated social aspect emanated from McHarg's Ecological Determinism design approach. The Woodlands, TX, USA, an ecologically designed community development under McHarg's approach, is compared with two adjacent communities that follow the conventional design approach. Using national environmental databases and multiple-year residents' survey information, this study assesses three landscape performance metrics of McHarg's approach: stormwater runoff, urban heat island effect, and social acceptance. Geographic Information Systems (GIS) was used to assess the development extent and land surface temperature distribution. Results show that McHarg's approach demonstrates benefits in reducing runoff and urban heat island effect, whereas it confronts challenges with the general acceptance of manicured landscapes and thus results in a low safety perception level when residents interact with naturally designed landscapes. The authors argue that design-with-nature warrants multifunctionality because of its intrinsic interdisciplinary approach. Moreover, education and dissemination of successful examples can achieve a greater level of awareness among the public and further promote multifunctional design for landscape sustainability. PMID:24169408

  8. Examining General Hospitals' Smoke-Free Policies

    Science.gov (United States)

    Whitman, Marilyn V.; Harbison, Phillip Adam

    2010-01-01

    Purpose: This paper aims to examine the level of smoke-free policies in general hospitals and the barriers faced in implementing restrictive policies banning smoking inside buildings and on surrounding grounds. Design/methodology/approach; A survey was developed to gather data on hospitals' current smoke-free policies, including the challenges…

  9. The Lead-Free Solder Selection Method and Process Optimization Based on Design of Experiment

    Directory of Open Access Journals (Sweden)

    Wang Bing

    2013-07-01

    Full Text Available In the study, through researching the characteristic of the lead-free solder, we introduce the method of QFD (Quality Function Deployment to transform the demand of production properties and process into the technical demand of the lead-free solder, thus we could transform the demand concept of sampling into a concrete performance index. Finally we can obtain two parameters of the technological competitive power index and market competitive power index to evaluate performance of the lead-free solder through making a series of experiments. We utilize the design of experiment method to find out key parameter of process and the best collocation of parameter, which make the co planarity of tin ball descend to 149 from 178 and promote the process’s ability up to 95.2 from 85%.

  10. Feasibility study on nuclear core design for soluble boron free small modular reactor

    Energy Technology Data Exchange (ETDEWEB)

    Rabir, Mohamad Hairie, E-mail: m-hairie@nuclearmalaysia.gov.my; Hah, Chang Joo; Ju, Cho Sung [Department of NPP Engineering, KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2015-04-29

    A feasibility study on nuclear core design of soluble boron free (SBF) core for small size (150MWth) small modular reactor (SMR) was investigated. The purpose of this study was to design a once through cycle SMR core, where it can be used to supply electricity to a remote isolated area. PWR fuel assembly design with 17×17 arrangement, with 264 fuel rods per assembly was adopted as the basis design. The computer code CASMO-3/MASTER was used for the search of SBF core and fuel assembly analysis for SMR design. A low critical boron concentration (CBC) below 200 ppm core with 4.7 years once through cycle length was achieved using 57 fuel assemblies having 170 cm of active height. Core reactivity controlled using mainly 512 number of 4 wt% and 960 12 wt% Gd rods.

  11. Feasibility study on nuclear core design for soluble boron free small modular reactor

    Science.gov (United States)

    Rabir, Mohamad Hairie; Hah, Chang Joo; Ju, Cho Sung

    2015-04-01

    A feasibility study on nuclear core design of soluble boron free (SBF) core for small size (150MWth) small modular reactor (SMR) was investigated. The purpose of this study was to design a once through cycle SMR core, where it can be used to supply electricity to a remote isolated area. PWR fuel assembly design with 17×17 arrangement, with 264 fuel rods per assembly was adopted as the basis design. The computer code CASMO-3/MASTER was used for the search of SBF core and fuel assembly analysis for SMR design. A low critical boron concentration (CBC) below 200 ppm core with 4.7 years once through cycle length was achieved using 57 fuel assemblies having 170 cm of active height. Core reactivity controlled using mainly 512 number of 4 wt% and 960 12 wt% Gd rods.

  12. Design Optimization of Structural Parameters for Highly Sensitive Photonic Crystal Label-Free Biosensors

    Directory of Open Access Journals (Sweden)

    Yun-ah Han

    2013-03-01

    Full Text Available The effects of structural design parameters on the performance of nano-replicated photonic crystal (PC label-free biosensors were examined by the analysis of simulated reflection spectra of PC structures. The grating pitch, duty, scaled grating height and scaled TiO2 layer thickness were selected as the design factors to optimize the PC structure. The peak wavelength value (PWV, full width at half maximum of the peak, figure of merit for the bulk and surface sensitivities, and surface/bulk sensitivity ratio were also selected as the responses to optimize the PC label-free biosensor performance. A parametric study showed that the grating pitch was the dominant factor for PWV, and that it had low interaction effects with other scaled design factors. Therefore, we can isolate the effect of grating pitch using scaled design factors. For the design of PC-label free biosensor, one should consider that: (1 the PWV can be measured by the reflection peak measurement instruments, (2 the grating pitch and duty can be manufactured using conventional lithography systems, and (3 the optimum design is less sensitive to the grating height and TiO2 layer thickness variations in the fabrication process. In this paper, we suggested a design guide for highly sensitive PC biosensor in which one select the grating pitch and duty based on the limitations of the lithography and measurement system, and conduct a multi objective optimization of the grating height and TiO2 layer thickness for maximizing performance and minimizing the influence of parameter variation. Through multi-objective optimization of a PC structure with a fixed grating height of 550 nm and a duty of 50%, we obtained a surface FOM of 66.18 RIU−1 and an S/B ratio of 34.8%, with a grating height of 117 nm and TiO2 height of 210 nm.

  13. Testing VHF/GPS collar design and safety in the study of free-roaming horses.

    Directory of Open Access Journals (Sweden)

    Gail H Collins

    Full Text Available Effective and safe monitoring techniques are needed by U.S. land managers to understand free-roaming horse behavior and habitat use and to aid in making informed management decisions. Global positioning system (GPS and very high frequency (VHF radio collars can be used to provide high spatial and temporal resolution information for detecting free-roaming horse movement. GPS and VHF collars are a common tool used in wildlife management, but have rarely been used for free-roaming horse research and monitoring in the United States. The purpose of this study was to evaluate the design, safety, and detachment device on GPS/VHF collars used to collect free-roaming horse location and movement data. Between 2009 and 2010, 28 domestic and feral horses were marked with commercial and custom designed VHF/GPS collars. Individual horses were evaluated for damage caused by the collar placement, and following initial observations, collar design was modified to reduce the potential for injury. After collar modifications, which included the addition of collar length adjustments to both sides of the collar allowing for better alignment of collar and neck shapes, adding foam padding to the custom collars to replicate the commercial collar foam padding, and repositioning the detachment device to reduce wear along the jowl, we observed little to no evidence of collar wear on horses. Neither custom-built nor commercial collars caused injury to study horses, however, most of the custom-built collars failed to collect data. During the evaluation of collar detachment devices, we had an 89% success rate of collar devices detaching correctly. This study showed that free-roaming horses can be safely marked with GPS and/or VHF collars with minimal risk of injury, and that these collars can be a useful tool for monitoring horses without creating a risk to horse health and wellness.

  14. A design study for the isolation of the 281-3H retention basin at the Savannah River Site using the viscous liquid barrier technology

    Energy Technology Data Exchange (ETDEWEB)

    Moridis, G.J.; Persoff, P.; Apps, J.; James, A.; Oldenburg, C.; McGrath, A.; Myer, L.; Pellerin, L.; Pruess, K. [Lawrence Berkeley National Lab., CA (United States). Earth Sciences Div.

    1996-11-01

    This report is a description of the design study for a pilot-scale field demonstration of the Viscous Liquid Barrier (VLB) technology, a new subsurface containment technology for waste isolation using a new generation of barrier liquids. The demonstration site was Retention Basin 281-3H, a shallow catchment basin at the Savannah River Site, which is contaminated mainly by radionuclides ({sup 137}Cs, {sup 90}Sr, and {sup 238}Pu). The goals of the field demonstration were (a) to demonstrate the ability to create a continuous subsurface barrier in order to isolate the contaminants, and (b) to demonstrate the continuity, performance, and integrity of the barrier. The site was characterized, and preliminary hydraulic conductivity data were obtained from core samples. Based on the site characteristics and the functional requirements, a conceptual model was developed, the barrier specifications were defined, and lance injection was selected as the emplacement method. The injection strategy for the subsurface conditions at the site was determined using numerical simulations. An appropriate variant of Colloidal Silica (CS) was selected as the barrier liquid based on its relative insensitivity to interactions with the site soils, and the formulation for optimum site performance was determined. A barrier verification strategy, including hydraulic, pneumatic, tracer, and geophysical methods, was developed. A lance water injection test was conducted in order to obtain representative estimates of the hydraulic conductivity and its distribution for the design of the barrier emplacement. The water injection test demonstrated the lack of permeable zones for CS injection, and a decision not to proceed with the barrier emplacement was reached.

  15. Free surface heat transfer and innovative designs for thin and thick liquid walls

    International Nuclear Information System (INIS)

    Design windows on free surface flows in the APEX (advanced power extraction) study are derived from the viewpoints of the free surface heat transfer, the adaptation of liquid flows to the topological constraints, and temperature requirements for plasma operation and power conversion efficiency. Within these constraints, the temperature of the free liquid surface facing the plasma is the most critical parameter governing the amount of liquid that evaporates into the plasma chamber. Present analyses show that a 2 cm or a 40 cm thick lithium layer can be established throughout the ARIES-RS reactor using a velocity of 10 m s-1 while operating under the plasma compatible surface temperature. However, like solid metallic walls, the liquid lithium walls require the use of electrical insulators to overcome the MHD drag. As for Flibe free surface flows, the MHD effect caused by interaction with the mean flow is negligible, while a fairly uniform flow of 2 or 45 cm thick can be maintained throughout the reactor based on 3-D hydrodynamics calculations. However, being a low thermally conducting medium, the Flibe surface temperature highly depends on the extent of the turbulent convection. The heat transfer analyses based on the κ-ε model of the turbulence, including MHD effects and various boundary conditions, predict a range of temperatures that may be beyond the plasma compatible temperatures. If indeed the Flibe surface temperature is high relative to the plasma operation limit, further design adjustments will be required to accommodate this deficiency

  16. A novel model-based hearing compensation design using a gradient-free optimization method.

    Science.gov (United States)

    Chen, Zhe; Becker, Suzanna; Bondy, Jeff; Bruce, Ian C; Haykin, Simon

    2005-12-01

    We propose a novel model-based hearing compensation strategy and gradient-free optimization procedure for a learning-based hearing aid design. Motivated by physiological data and normal and impaired auditory nerve models, a hearing compensation strategy is cast as a neural coding problem, and a Neurocompensator is designed to compensate for the hearing loss and enhance the speech. With the goal of learning the Neurocompensator parameters, we use a gradient-free optimization procedure, an improved version of the ALOPEX that we have developed, to learn the unknown parameters of the Neurocompensator. We present our methodology, learning procedure, and experimental results in detail; discussion is also given regarding the unsupervised learning and optimization methods. PMID:16212766

  17. Singularity-free Design of the Translational Parallel Manipulator IRSBot-2

    OpenAIRE

    Germain, Coralie; Caro, Stéphane; Briot, Sébastien; Wenger, Philippe

    2013-01-01

    The IRSBot-2 is a two degree-of-freedom translational parallel manipulator dedicated to fast and accurate pick-and-place operations. This paper deals with the determination of the design parameters of the manipulator for the IRSBot-2 to be free of parallel singularity. First, the robot architecture is introduced. The IRSBot-2 is composed of two identical spatial limbs, each one containing a proximal module and a distal module. Then, its actuation singularities and constraint singularities are...

  18. Influence of the Thermal Barrier Coatings Design on the Oxidation Behavior

    Institute of Scientific and Technical Information of China (English)

    B.Saeedi; A.Sabour; A.Ebadi; A.M.Khoddami

    2009-01-01

    The properties of two different types of thermal barrier coatings (TBCs) were compared to improve the surface characteristics on high temperature components. These TBCs consisted of a duplex TBC and a five-layered functionally graded TBC. NiCrAlY bond coats were deposited on a number of Inconel-738LC specimens using high velocity oxy-fuel spraying (HVOF) technique. For duplex coating, a group of these specimens were coated with yttria stabilized zirconia (YSZ) using plasma spray technique. Functionally graded NiCrAlY/YSZ coatings were fabricated by plasma spray using co-injection of the two different powders in a single plasma torch. The amount of zirconia in functionally graded coatings were gradually increased from 30 to 100 vol. pct. Microstructural changes, thermally grown oxide (TGO) layer growth and damage initiation of the coatings were investigated as a function of isothermal oxidation test at 970℃. As a complementary test, the performance of the fabricated coatings by the optimum processing conditions was evaluated as a function of intense thermal cycling test at 1100℃. Also the strength of the adhesive coatings of the substrate was also measured. Microstructural characterization was analyzed by scanning electron microscopy (SEM) and optical microscopy whereas phase analysis and chemical composition changes of the coatings and oxides formed during the tests were studied by XRD (X-ray diffraction) and EDS (energy dispersive spectrometer). The results showed that microstructure and compositions gradually varied in the functionally graded coatings. By comparison of duplex and functionally graded TBCs oxidation behavior (duplex failure after 1700 h and funcitionally graded TECs failure after 2000 h), thermal shock test and adhesion strength of the coatings, the functionally graded TBC had better performance and more durability.

  19. Design of an infra-red free-electron laser at RRCAT

    International Nuclear Information System (INIS)

    An infrared free-electron laser (IR-FEL) that will be tunable at around 30 μm wavelength is currently being developed at the Raja Ramanna Centre for Advanced Technology (RRCAT), Indore. The FEL will use a 15- 25 MeV normal conducting linear accelerator and a 50 mm period, 2.5 m long undulator housed in a 4.1 m long optical cavity. In this paper, we discuss the physics design of the IR-FEL and the design/development of various sub-systems. (author)

  20. Beyond consensus: statistical free energies reveal hidden interactions in the design of a TPR motif.

    Science.gov (United States)

    Magliery, Thomas J; Regan, Lynne

    2004-10-22

    Consensus design methods have been used successfully to engineer proteins with a particular fold, and moreover to engineer thermostable exemplars of particular folds. Here, we consider how a statistical free energy approach can expand upon current methods of phylogenetic design. As an example, we have analyzed the tetratricopeptide repeat (TPR) motif, using multiple sequence alignment to identify the significance of each position in the TPR. The results provide information above and beyond that revealed by consensus design alone, especially at poorly conserved positions. A particularly striking finding is that certain residues, which TPR-peptide co-crystal structures show are in direct contact with the ligand, display a marked hypervariability. This suggests a novel means of identifying ligand-binding sites, and also implies that TPRs generally function as ligand-binding domains. Using perturbation analysis (or statistical coupling analysis), we examined site-site interactions within the TPR motif. Correlated occurrences of amino acid residues at poorly conserved positions explain how TPRs achieve their near-neutral surface charge distributions, and why a TPR designed from straight consensus has an unusually high net charge. Networks of interacting sites revealed that TPRs fall into two unrecognized families with distinct sets of interactions related to the identity of position 7 (Leu or Lys/Arg). Statistical free energy analysis provides a more complete description of "What makes a TPR a TPR?" than consensus alone, and it suggests general approaches to extend and improve the phylogenetic design of proteins.

  1. ELOIS: an innovative spectrometer design using a free-form grating

    Science.gov (United States)

    De Clercq, Coralie; Moreau, Vincent; Jamoye, Jean-François; Zuccaro Marchi, Alessandro; Gloesener, Pierre

    2015-09-01

    For spaceborne hyperspectral applications1, grating-based spectrometers are of special interest due to the high spectral resolution and optical throughput that can be achieved. The classical spectrometer designs are 1:1 systems. For these systems the achievable signal to noise ratio is limited by the slit width/pixel pitch combination. One way to increase the signal to noise ratio of a spectrometer without increasing the global instrument size is to design an instrument with a magnification power of less than one. With a smaller magnification, the entrance slit is wider and a larger amount of light is collected while the image is smaller and compatible with typical detector size and pixel pitch. We presents an innovative spectrometer design with 2:1 magnification and high image quality and radiometric performances. This spectrometer called ELOIS (for Enhanced Light Offner Imaging Spectrometer) is designed with a grating atop a free-form surface. The use non-rotationally symmetric surfaces offer additional freedom for designing compact and well-corrected instruments. Nevertheless, most of the available manufacturing techniques, such as direct ruling, holography, lithography or e-beam writing, are typically applicable on simple shape of the grating surface, such as flat or spherical surface. AMOS demonstrated the feasibility of the Free Form Grating (FFG), i.e. a ruled grating on a surface without any rotational symmetry, using cost-effective approach for manufacturing blazed grating by Single Point Diamond Turning (SPDT).

  2. Designing molecular complexes using free-energy derivatives from liquid-state integral equation theory.

    Science.gov (United States)

    Mrugalla, Florian; Kast, Stefan M

    2016-09-01

    Complex formation between molecules in solution is the key process by which molecular interactions are translated into functional systems. These processes are governed by the binding or free energy of association which depends on both direct molecular interactions and the solvation contribution. A design goal frequently addressed in pharmaceutical sciences is the optimization of chemical properties of the complex partners in the sense of minimizing their binding free energy with respect to a change in chemical structure. Here, we demonstrate that liquid-state theory in the form of the solute-solute equation of the reference interaction site model provides all necessary information for such a task with high efficiency. In particular, computing derivatives of the potential of mean force (PMF), which defines the free-energy surface of complex formation, with respect to potential parameters can be viewed as a means to define a direction in chemical space toward better binders. We illustrate the methodology in the benchmark case of alkali ion binding to the crown ether 18-crown-6 in aqueous solution. In order to examine the validity of the underlying solute-solute theory, we first compare PMFs computed by different approaches, including explicit free-energy molecular dynamics simulations as a reference. Predictions of an optimally binding ion radius based on free-energy derivatives are then shown to yield consistent results for different ion parameter sets and to compare well with earlier, orders-of-magnitude more costly explicit simulation results. This proof-of-principle study, therefore, demonstrates the potential of liquid-state theory for molecular design problems. PMID:27366935

  3. Designing molecular complexes using free-energy derivatives from liquid-state integral equation theory

    Science.gov (United States)

    Mrugalla, Florian; Kast, Stefan M.

    2016-09-01

    Complex formation between molecules in solution is the key process by which molecular interactions are translated into functional systems. These processes are governed by the binding or free energy of association which depends on both direct molecular interactions and the solvation contribution. A design goal frequently addressed in pharmaceutical sciences is the optimization of chemical properties of the complex partners in the sense of minimizing their binding free energy with respect to a change in chemical structure. Here, we demonstrate that liquid-state theory in the form of the solute-solute equation of the reference interaction site model provides all necessary information for such a task with high efficiency. In particular, computing derivatives of the potential of mean force (PMF), which defines the free-energy surface of complex formation, with respect to potential parameters can be viewed as a means to define a direction in chemical space toward better binders. We illustrate the methodology in the benchmark case of alkali ion binding to the crown ether 18-crown-6 in aqueous solution. In order to examine the validity of the underlying solute-solute theory, we first compare PMFs computed by different approaches, including explicit free-energy molecular dynamics simulations as a reference. Predictions of an optimally binding ion radius based on free-energy derivatives are then shown to yield consistent results for different ion parameter sets and to compare well with earlier, orders-of-magnitude more costly explicit simulation results. This proof-of-principle study, therefore, demonstrates the potential of liquid-state theory for molecular design problems.

  4. Generation of large-scale, barrier-free diffuse plasmas in air at atmospheric pressure using array wire electrodes and nanosecond high-voltage pulses

    Science.gov (United States)

    Teng, Yun; Li, Lee; Liu, Yun-Long; Liu, Lun; Liu, Minghai

    2014-10-01

    This paper introduces a method to generate large-scale diffuse plasmas by using a repetition nanosecond pulse generator and a parallel array wire-electrode configuration. We investigated barrier-free diffuse plasmas produced in the open air in parallel and cross-parallel array line-line electrode configurations. We found that, when the distance between the wire-electrode pair is small, the discharges were almost extinguished. Also, glow-like diffuse plasmas with little discharge weakening were obtained in an appropriate range of line-line distances and with a cathode-grounding cross-electrode configuration. As an example, we produced a large-scale, stable diffuse plasma with volumes as large as 18 × 15 × 15 cm3, and this discharge region can be further expanded. Additionally, using optical and electrical measurements, we showed that the electron temperature was higher than the gas temperature, which was almost the same as room temperature. Also, an array of electrode configuration with more wire electrodes had helped to prevent the transition from diffuse discharge to arc discharge. Comparing the current waveforms of configurations with 1 cell and 9 cells, we found that adding cells significantly increased the conduction current and the electrical energy delivered in the electrode gaps.

  5. Design of a cusped field thruster for drag-free flight

    Science.gov (United States)

    Liu, H.; Chen, P. B.; Sun, Q. Q.; Hu, P.; Meng, Y. C.; Mao, W.; Yu, D. R.

    2016-09-01

    Drag-free flight has played a more and more important role in many space missions. The thrust control system is the key unit to achieve drag-free flight by providing a precise compensation for the disturbing force except gravity. The cusped field thruster has shown a significant potential to be capable of the function due to its long life, high efficiency, and simplicity. This paper demonstrates a cusped field thruster's feasibility in drag-free flight based on its instinctive characteristics and describes a detailed design of a cusped field thruster made by Harbin Institute of Technology (HIT). Furthermore, the performance test is conducted, which shows that the cusped field thruster can achieve a continuously variable thrust from 1 to 20 mN with a low noise and high resolution below 650 W, and the specific impulse can achieve 1800 s under a thrust of 18 mN and discharge voltage of 1000 V. The thruster's overall performance indicates that the cusped field thruster is quite capable of achieving drag-free flight. With the further optimization, the cusped field thruster will exhibit a more extensive application value.

  6. Free energy calculations to estimate ligand-binding affinities in structure-based drug design.

    Science.gov (United States)

    Reddy, M Rami; Reddy, C Ravikumar; Rathore, R S; Erion, Mark D; Aparoy, P; Reddy, R Nageswara; Reddanna, P

    2014-01-01

    Post-genomic era has led to the discovery of several new targets posing challenges for structure-based drug design efforts to identify lead compounds. Multiple computational methodologies exist to predict the high ranking hit/lead compounds. Among them, free energy methods provide the most accurate estimate of predicted binding affinity. Pathway-based Free Energy Perturbation (FEP), Thermodynamic Integration (TI) and Slow Growth (SG) as well as less rigorous end-point methods such as Linear interaction energy (LIE), Molecular Mechanics-Poisson Boltzmann./Generalized Born Surface Area (MM-PBSA/GBSA) and λ-dynamics have been applied to a variety of biologically relevant problems. The recent advances in free energy methods and their applications including the prediction of protein-ligand binding affinity for some of the important drug targets have been elaborated. Results using a recently developed Quantum Mechanics (QM)/Molecular Mechanics (MM) based Free Energy Perturbation (FEP) method, which has the potential to provide a very accurate estimation of binding affinities to date has been discussed. A case study for the optimization of inhibitors for the fructose 1,6- bisphosphatase inhibitors has been described. PMID:23947646

  7. Free-surface Fluctuations For Design of Submerged-Entry Nozzle

    Directory of Open Access Journals (Sweden)

    Rajat Kumar Das

    2012-08-01

    Full Text Available Free surface fluctuation and surface velocity fluctuation of molten steel in the mold of a continuous caster is considered with different types of submerged entry nozzles (SENs. In the present work, instead of steel and argon, water and air enter into the mold. An interface capturing scheme is used to predict the shape of free surface that is created in the mold. It has been observed that air entrapment by the surface wave does not take place for low inlet velocity (<1 m/s of SEN . But at high inlet velocity (3m/s air entrapment takes place at the surface in to the mold to form bubbles .Three different SEN models were taken for numerical analysis. Contribution of water, air velocity and size of upper recirculation roll on free surface fluctuation were particularly investigated for designing of submerged entry nozzle. It was found that 15 degree down port nozzle is a better one as it shows lesser free surface fluctuation.

  8. Free-form thin lens design with light scattering surfaces for practical LED down light illumination

    Science.gov (United States)

    Lin, Raychiy J.; Sun, Ching-Cherng

    2016-05-01

    The free-form optical quasilens surface technology was utilized to develop and design a solid transparent plastic optical lens for the LED down light with the narrow angular light distribution requirement in the LED lighting applications. In order to successfully complete the mission, the precise mid-field angular distribution model of the LED light source was established and built. And also the optical scattering surface property of the Harvey BSDF scattering model was designed, measured, and established. Then, the optical simulation for the entire optical system was performed to develop and design this solid transparent plastic optical lens system. Finally, the goals of 40 deg angular light distribution pattern defined at full width half maximum with glare reduced in the areas of interest and the optical performance of nearly 82% light energy transmission optics were achieved for the LED down light illumination.

  9. High Bandwidth Pickup Design for Bunch Arrival-time Monitors for Free-Electron Laser

    CERN Document Server

    Angelovski, Aleksandar; Hansli, Matthias; Penirschke, Andreas; Schnepp, Sascha M; Bousonville, Michael; Schlarb, Holger; Bock, Marie Kristin; Weiland, Thomas; Jakoby, Rolf

    2012-01-01

    In this paper, we present the design and realization of high bandwidth pickup electrodes with a cutoff frequency above 40 GHz. The proposed cone-shaped pickups are part of a bunch arrival-time monitor (BAM) designed for high (> 500 pC) and low (20 pC) bunch charge operation mode providing for a time resolution of less than 10 fs for both operation modes. The proposed design has a fast voltage response, low ringing, and a resonance-free spectrum. For assessing the influence of manufacturing tolerances on the performance of the pickups, an extensive tolerance study has been performed via numerical simulations. A non-hermetic model of the pickups was built for measurement and validation purposes. The measurement and simulation results are in good agreement and demonstrate the capability of the proposed pickup system to meet the given specifications.

  10. Free material stiffness design of laminated composite structures using commercial finite element analysis codes

    DEFF Research Database (Denmark)

    Henrichsen, Søren Randrup; Lindgaard, Esben; Lund, Erik

    2015-01-01

    In this work optimum stiffness design of laminated composite structures is performed using the commercially available programs ANSYS and MATLAB. Within these programs a Free Material Optimization algorithm is implemented based on an optimality condition and a heuristic update scheme. The heuristic...... update scheme is needed because commercially available finite element analysis software is used. When using a commercial finite element analysis code it is not straight forward to implement a computationally efficient gradient based optimization algorithm. Examples considered in this work are a clamped......-clamped 2D plate loaded in two load cases and a point loaded six layered 3D double curved corner hinged shell. The first example displays the effect of varying the size of patches having the same parametrization, and the second illustrates the benefit of using a layered free material parametrization...

  11. Designed to deter: Barriers to facilities at secondary schools in Ghana

    Directory of Open Access Journals (Sweden)

    Anthony K. Danso

    2012-05-01

    Full Text Available Background: There are varied and complex problems associated with the admission of students with disabilities into secondary (senior high schools all over the world. This situation is further complicated by difficulties encountered in the built environment of these institutions and, in this, Ghana is no exception. Objectives: This exploratory study investigated the level of accessibility of the built environment in secondary schools in eight out of the ten regions of Ghana, in order to determine whether they conform to guidelines provided in international building standards and also assess the extent to which they have been designed and constructed to meet the provisions of the Persons with Disability Act 2006, which allows for equal access to public buildings in Ghana.Method: In total, 705 building elements in 264 facilities were surveyed using international standards, building codes, regulations and guidelines. These facilities included car parks, classrooms, dormitories, assembly halls, telephone booths and administration blocks.Results: Our findings revealed that most of the building elements were barring and not disability-friendly. Just to name a few: there were obstructions on access routes to and around buildings, absence of designated car parks, unfriendly vertical and horizontal means of circulation in buildings and lack of accessible sanitary accommodations. In addition, the general lighting and signage were poor. As a result, very few students with disabilities are admitted and retained in these schools.Conclusion: Mainstreaming of people with disabilities into the Ghanaian educational system remains impossible unless urgent action is taken to alter the facilities at secondary schools. Based on this research outcome, recommendations have been made to the Ghanaian government and the Ghana Education Service, as well as non-governmental organisations and relevant professional bodies for the amelioration of the present situation in our

  12. Opportunities and barriers for implementing CO2 capture ready designs: A case study of stakeholder perceptions in Guangdong, China

    International Nuclear Information System (INIS)

    China has been building at least 50 gigawatt (GW) of new coal-fired power plants every year since 2004. In the absence of CO2 capture ready (CCR) designs, a large fraction of new coal power plants built in the next decade could face ‘carbon lock-in’. Building on the existing engineering and economic literature on CO2 capture ready, the aim of this study is to understand the opportunities and challenges in implementing CCR in China. In early 2010, opinion-leaders perceptions towards implementing CCR in Guangdong with two empirical phases are presented: an online consultation of 31 respondents (out of a sample of 82), three face-to-face focus group discussions including 16 officials from five power plants and two oil companies in the Guangdong province. A majority of respondents in the online survey were engineers. The survey results are compared with an earlier study of stakeholders’ views on demonstrating CCS in China, conducted in April 2009 as part of the EU–UK–China Near Zero Emissions Coal initiative (NZEC) project. - Highlights: ► Without national support, interests from project management and local government help deploy CCR. ► Space on-site and access to storage sites are two essential criteria. ► It is also necessary to investigate the local plant design conventions and regulations. ► Five potential barriers to implementing CCR are identified. ► Four potential drivers may accelerate the implementation of CCR.

  13. Improvement Strategy of the Barrier-free Pedestrian System around Representative Region of Urban Transportation%典型区域周边交通设施无障碍化方法研究

    Institute of Scientific and Technical Information of China (English)

    刘新华; 蒋光胜; 钱堃; 陈松

    2011-01-01

    It is very important to improve the service level of barrier-free traffic system to protect the aged and the disabled and adapt to the trend of population aging of our country. This study has summarized the common problems of barrier-free facilities around hospitals, shopping areas and parks and proposed corresponding countermeasures based on the analysis of present service level of barrier-free facilities in our country. Index evaluation system on the improvement effect of barrier-free traffic facilities around parks is established with the actual situation of barrier-free traffic facilities in typical region. Finally, the reason of low service level of the barrier-free facilities has been analyzed and three improvement proposals have been discussed by simulating Taiping Street nearby the east gate of Taoranting Park. Meanwhile, the effect of the improvement has been evaluated with using the index evaluation system. It is turned out that the delay of the pedestrian is reduced by 67.4% after the implementation of the proposed methods.%交通设施无障碍化程度的提高对于保障老年人和残疾人的交通安全、适应我国人口结构老龄化趋势具有十分重要的意义.本文在分析我国无障碍服务水平现状的基础上,归纳了医院、购物场所和公园周边无障碍交通设施的常见问题,提出了相应的改善措施;然后,结合典型区域周边交通设施无障碍化的实际情况,建立了公园周边交通设施无障碍化改善效果的评价指标体系;最后,结合陶然亭公园东门的太平街道路交通实例,分析了该路段交通无障碍服务水平较低的原因,提出了3个改善方案,并利用评价指标体系对改善效果进行评价;最后应用VISSIM仿真得到,改善方案实施后,行人延误降低了67.4%.

  14. Updated free span design procedure DNV RP-F105 Ormen Lange experiences

    Energy Technology Data Exchange (ETDEWEB)

    Fyrileiv, Olav; Moerk, Kim; Chezhian, Muthu [Det Norsk Veritas (Norway)

    2005-07-01

    The Ormen Lange gas field is located within a prehistoric slide area with varying water depths from 250 to 1100 m. Due to the slide area, the seabed is very uneven including steep slopes and seabed obstacles up to 50 meters tall. The major technical challenges with respect to pipeline design in this area are: extreme seabed topography combined with inhomogeneous soil conditions; uncertainties related to current velocities and distribution; high number of spans including some very long spans; deep waters and therefore difficult and costly seabed preparation/span intervention; flowlines with large potential to buckle laterally in combination with free spans. In order to minimise span intervention costs, a major testing campaign and research programme has been conducted in the Ormen Lange project to come up with a design procedure in compliance with the DNV-RP-F105 (DNV, 2002) design philosophy. The improvements in terms of reduced seabed intervention and rock dumping costs are in the order of several 100 MNOKs. The lessons learned and the improved knowledge will also be a great value for other project dealing with similar free span problems. (author)

  15. Experimental Design for One Dimensional Electrolytic Reactive Barrier for Remediation of Munition Constituent in Groundwater

    Science.gov (United States)

    Gent, David B.; Wani, Altaf; Alshawabkeh, Akram N.

    2012-01-01

    A combination of direct electrochemical reduction and in-situ alkaline hydrolysis has been proposed to decompose energetic contaminants such as 1,3,5-Trinitroperhydro- 1,3,5-triazine and 2,4,6-Trinitrotoluene (RDX) in deep aquifers. This process utilizes natural groundwater convection to carry hydroxide produced by an upstream cathode to remove the contaminant at the cathode as well as in the pore water downstream as it migrates toward the anode. Laboratory evaluation incorporated fundamental principles of column design coupled with reactive contaminant modeling including electrokinetics transport. Batch and horizontal sand-packed column experiments included both alkaline hydrolysis and electrochemical treatment to determine RDX decomposition reaction rate coefficients. The sand packed columns simulated flow through a contaminated aquifer with a seepage velocity of 30.5 cm/day. Techniques to monitor and record the transient electric potential, hydroxide transport and contaminant concentration within the column were developed. The average reaction rate coefficients for both the alkaline batch (0.0487 hr−1) and sand column (0.0466 hr−1) experiments estimated the distance between the cathode and anode required to decompose 0.5 mg/L RDX to the USEPA drinking water lifetime Health Advisory level of 0.002 mg/L to be 145 and 152 cm. PMID:23472044

  16. Experimental Design for One Dimensional Electrolytic Reactive Barrier for Remediation of Munition Constituent in Groundwater.

    Science.gov (United States)

    Gent, David B; Wani, Altaf; Alshawabkeh, Akram N

    2012-12-30

    A combination of direct electrochemical reduction and in-situ alkaline hydrolysis has been proposed to decompose energetic contaminants such as 1,3,5-Trinitroperhydro- 1,3,5-triazine and 2,4,6-Trinitrotoluene (RDX) in deep aquifers. This process utilizes natural groundwater convection to carry hydroxide produced by an upstream cathode to remove the contaminant at the cathode as well as in the pore water downstream as it migrates toward the anode. Laboratory evaluation incorporated fundamental principles of column design coupled with reactive contaminant modeling including electrokinetics transport. Batch and horizontal sand-packed column experiments included both alkaline hydrolysis and electrochemical treatment to determine RDX decomposition reaction rate coefficients. The sand packed columns simulated flow through a contaminated aquifer with a seepage velocity of 30.5 cm/day. Techniques to monitor and record the transient electric potential, hydroxide transport and contaminant concentration within the column were developed. The average reaction rate coefficients for both the alkaline batch (0.0487 hr(-1)) and sand column (0.0466 hr(-1)) experiments estimated the distance between the cathode and anode required to decompose 0.5 mg/L RDX to the USEPA drinking water lifetime Health Advisory level of 0.002 mg/L to be 145 and 152 cm.

  17. Design and Implementation of a Sort-Free K-Best Sphere Decoder

    KAUST Repository

    Mondal, Sudip

    2012-10-18

    This paper describes the design and VLSI architecture for a 4x4 breadth first K-Best MIMO decoder using a 64 QAM scheme. A novel sort free approach to path extension, as well as quantized metrics result in a high throughput VLSI architecture with lower power and area consumption compared to state of the art published systems. Functionality is confirmed via an FPGA implementation on a Xilinx Virtex II Pro FPGA. Comparison of simulation and measurements are given and FPGA utilization figures are provided. Finally, VLSI architectural tradeoffs are explored for a synthesized ASIC implementation in a 65nm CMOS technology.

  18. Design of a scanning gate microscope in a cryogen-free dilution refrigerator

    Science.gov (United States)

    Pelliccione, Matthew; Sciambi, Adam; Goldhaber-Gordon, David

    2011-03-01

    We report on our design of an ultra-low temperature scanning gate microscope housed in a system with no liquid helium bath. The recent increase in efficiency of pulse-tube cryocoolers and pending scarcity of liquid helium have made ``cryogen-free'' dewars popular in recent years. However, this new style of dewar presents challenges for performing scanning measurements, most notably the increased vibrations introduced by the cryocooler. We will highlight the tradeoffs made in choosing such a system to house a scanner, and describe our efforts to achieve a stability suitable for measurements on mesoscopic systems.

  19. Estimation of free energy barriers in the cytoplasmic and mitochondrial aspartate aminotransferase reactions probed by hydrogen-exchange kinetics of C alpha-labeled amino acids with solvent

    Energy Technology Data Exchange (ETDEWEB)

    Julin, D.A.; Wiesinger, H.; Toney, M.D.; Kirsch, J.F. (Univ. of California, Berkeley (USA))

    1989-05-02

    The existence of the postulated quinonoid intermediate in the cytoplasmic aspartate amino-transferase catalyzed transamination of aspartate to oxaloacetate was probed by determining the extent of transfer of tritium from the C alpha position of tritiated L-aspartate to pyridoxamine 5'-phosphate in single turnover experiments in which washout from the back-reaction was obviated by product trapping. The maximum amount of transferred tritium observed was 0.7%, consistent either with a mechanism in which a fraction of the net transamination reaction proceeds through a quinonoid intermediate or with a mechanism in which this intermediate is formed off the main reaction pathway. It is shown that transfer of labeled hydrogen from the amino acid to cofactor cannot be used to differentiate a stepwise from a concerted transamination mechanism. The amount of tritium transferred is a function of the rate constant for torsional equilibration about the epsilon-amino group of Lys-258, the presumptive abstractor of the C alpha proton; the relative rate constants for hydrogen exchange with solvent versus cofactor protonation; and the tritium isotope effect on this ratio. The free energy barriers facing the covalent intermediate between aldimine and keto acid product (i.e., ketimine and possibly quinonoid) were evaluated relatively by comparing the rates of C alpha-hydrogen exchange in starting amino acid with the rates of keto acid formation. The value of theta (= kexge/kprod) was found to be 2.6 for the reaction of cytoplasmic isozyme with aspartate and ca. 0.5 for that of the mitochondrial form with glutamate.

  20. Intra-Arterial Delivery of Bevacizumab after Blood-Brain Barrier Disruption for the Treatment of Recurrent Glioblastoma: Progression-Free Survival and Overall Survival

    Science.gov (United States)

    Burkhardt, Jan-Karl; Riina, Howard; Shin, Benjamin J.; Christos, Paul; Kesavabhotla, Kartik; Hofstetter, Christoph P.; Tsiouris, Apostolos John; Boockvar, John A.

    2013-01-01

    BACKGROUND This prospective, single-center study assesses progression-free survival (PFS) and overall survival (OS) in patients with recurrent glioblastoma multiforme (GBM) treated with a single dose of superselective intra-arterial cerebral infusion (SIACI) of bevacizumab (BV) after blood-brain barrier disruption (BBBD). Patients were initially enrolled in our phase I study, for which the primary end point was to determine the safety and maximum tolerated dose of SIACI BV. METHODS Fourteen patients with recurrent GBM were recruited between August 2009 and November 2010 after failing the standard treatment with radiation therapy and temozolomide. None of these patients were previously treated with BV. After receiving a single dose of IA BV (2 to 15 mg/kg), standard IV BV chemotherapy was continued in 12 of 14 patients (86%). The recently updated Response Assessment in Neuro-Oncology Working Group (RANO) criteria were used to evaluate PFS, and the Kaplan-Meier estimator was used to evaluate PFS and OS. RESULTS Using RANO criteria, the median PFS in these patients was 10 months. The median OS estimation for this cohort was 8.8 months. The OS was less than the PFS because 4 patients died without progressing. Toxicity attributed to the IA BV treatment was present in 2 patients (wound dehiscence and rash). Another patient suffered from seizures 1 week after the SIACI procedure; however, this patient had epilepsy before and seizure type/frequency were similar before and after therapy. CONCLUSIONS Our study shows that for patients naïve to BV, a single dose of SIACI BV after BBBD followed by IV BV offers an encouraging outcome in terms of PFS when compared with previous trials using IV BV with and without concomitant irinotecan (CPT-11). Larger phase II trials are warranted to determine whether repeated IA BV alone is superior to IV BV for recurrent GBM. PMID:22405392

  1. Problems of Children with Special Needs (CWSNs in Assessing the Education: Role of Barrier Free Environment - A Case Study of India

    Directory of Open Access Journals (Sweden)

    D. Uma Devi

    2016-08-01

    Full Text Available Education is envisaged as an important tool for the socio-economic and cultural development of an individual and acts as a catalyst for the pace of the development of the country. Keeping this in view, the Government of India has launched several programmes for the promotion of the education among the children as well as adults in the country. But, due to the malnutrition, superstitions, fluoride in the water, diseases like polio etc., natural calamities and other adverse conditions some children are becoming disabled. The place of the differently abled in the Indian society is lower when compared with the normal children as there is a notion that their disability is due to curse for the sins in the previous birth etc. and they were deprived in all spheres of life including education. To mainstream them on par with the normal population and to make them as partners of the pace of development of the country, the Government of India from time to time launched several programmes and started special schools. Sarva Shiksha Abhiyan is one of the programme implemented to create barrier free environment in the school and to promote inclusive education for the children with special needs (CWSN as one of the components. The present study was taken up in the state of Andhra Pradesh in India to find out the extent of accessibility of education to the CWSNs in normal schools. The study covered a sample of CWSNs (300, teachers (90, parents (150, heads of the schools (30, home based teachers (30 and tried to identify the problems of the CWSNs in accessing the education, problems of the teachers in tackling with the children, parents opinions towards the efforts of the schools in making education to be accessible to their CSWN.

  2. Design, construction and characterization of the compact ultrafast terahertz free-electron laser undulator

    Indian Academy of Sciences (India)

    B Biswas; V Kumar; S Chouksey; S Krishnagopal

    2008-12-01

    A compact ultrafast terahertz (CUTE) free-electron laser (FEL) is being developed at the Raja Ramanna Centre for Advanced Technology (RRCAT), Indore. The undulator required for the CUTE-FEL has recently been developed. We have designed, built and characterized a variable gap, 5 cm period, 2.5 m long pure permanent magnet undulator in two identical segments. The tolerable error in the magnetic field was 1% in rms, and we have measured it to be 0.7%. The obtained rms phase shake is around 2°. To ensure that the trajectories do not have an exit error in position or angle, corrector coils have been designed. Shimming coils have been applied for both the undulator segments to reduce the amplitude of the betatron oscillations in the vertical trajectory. Details of novel corrector coils and soft iron shims are given and their performance is discussed.

  3. Computer aided design of free-machinability prehardened mold steel for plastic

    Institute of Scientific and Technical Information of China (English)

    HE Yan-lin; LI Lin; GAO Wen; WANG Qing-liang; WU Xiao-chun

    2005-01-01

    In order to improve the machinability but not to impair other properties of the prehardened mold steel for plastic, the composition was designed by application of Thermo-Calc software package to regulate the type of nonmetallic inclusion formed in the steel. The regulated non-metallic inclusion type was also observed by SEM and EDX. Then the maehinability assessment of the steel with designed composition under different conditions was studied by the measurement of tool wear amount and cutting force. The results show that the composition of free cutting elements adding to mold steel for plastic can be optimized to obtain proper type of non-metallic inclusion in the aid of Thermo-Calc, compared with the large volume fraction of soft inclusion which is needed for promoting ductile fracture at low cutting speeds, the proper type of inclusion at high cutting speeds is glassy oxide inclusion. All those can be obtained in the present work.

  4. Optimal design of label-free silicon “lab on a chip” biosensors

    Institute of Scientific and Technical Information of China (English)

    Yaping Zhang

    2013-01-01

    This paper reported the optimal design of label-free silicon on insulator (SOI)“lab on a chip”biosensors. These devices are designed on the basis of the evanescent field detection principles and interferometer technologies. The well-established silicon device process technology can be applied to fabricate and test these biosensor devices. In addition, these devices can be monolithically integrated with CMOS electronics and microfluidics. For these biosensor devices, multi-mode interferometer (MMI) was employed to combine many stand-alone biosensors to form chip-level biosensor arrays, which enable real-time and label-free monitoring and parallel detection of various analytes in multiple test samples. This sensing and detection technology features the highest detection sensitivity, which can detect analytes at extremely low concentrations instantaneously. This research can lead to innovative commercial development of the new generation of high sensitivity biosensors for a wide range of applications in many fields, such as environmental monitoring, food security control, medical and biological applications.

  5. Design and Implementation of Noise Free Audio Speech Signal Using Fast Block Least Mean Square Algorithm

    Directory of Open Access Journals (Sweden)

    J. Jebastine

    2012-06-01

    Full Text Available This paper describes the development of an adaptive noise cancellation algorithm for effective recognition of speech signal and also to improve SNR for an adaptive step size input. An adaptive filter with Fast Block Least Mean square Algorithm is designed for noise free audio (speech/music signals. The signal input used is a audio speech signal which could be in the form of a recorded voice. The filter used is adaptive filter and the algorithm used is Fast Block LMS algorithm. A Gaussian noise is added to this input signal and given as a input to the Fast Block LMS. The algorithm is implemented in Matlab and was tested for noise cancellation in speech signals. A Simulink model is designed which results in a noise free audio speech signal at the output. The FBLMS algorithm is computationally efficient in noise cancellation. The noise level in speech signal can be 1 mild, 2 moderate, 3 severe. The SNR is estimated by varying the adaptive step size.

  6. Design and Implementation of Noise Free Audio Speech Signal Using Fast Block Least Mean Square Algorithm

    Directory of Open Access Journals (Sweden)

    J. Jebastine

    2012-07-01

    Full Text Available This paper describes the development of an adaptive noise cancellation algorithm for effective recognition of speech signal and also to improve SNR for an adaptive step size input. An adaptive filter with Fast Block Least Mean square Algorithm is designed for noise free audio (speech/music signals. The signal input used is a audio speech signal which could be in the form of a recorded voice. The filter used is adaptive filter and the algorithm used is Fast Block LMS algorithm. A Gaussian noise is added to this input signal and given as a input to the Fast Block LMS. The algorithm is implemented in Matlab and was tested fornoise cancellation in speech signals. A Simulink model is designed which results in a noise free audiospeech signal at the output. The FBLMS algorithm is computationally efficient in noise cancellation. The noise level in speech signal can be 1 mild, 2 moderate, 3 severe. The SNR is estimated by varying the adaptive step size.

  7. Protein:Ligand binding free energies: A stringent test for computational protein design.

    Science.gov (United States)

    Druart, Karen; Palmai, Zoltan; Omarjee, Eyaz; Simonson, Thomas

    2016-02-01

    A computational protein design method is extended to allow Monte Carlo simulations where two ligands are titrated into a protein binding pocket, yielding binding free energy differences. These provide a stringent test of the physical model, including the energy surface and sidechain rotamer definition. As a test, we consider tyrosyl-tRNA synthetase (TyrRS), which has been extensively redesigned experimentally. We consider its specificity for its substrate l-tyrosine (l-Tyr), compared to the analogs d-Tyr, p-acetyl-, and p-azido-phenylalanine (ac-Phe, az-Phe). We simulate l- and d-Tyr binding to TyrRS and six mutants, and compare the structures and binding free energies to a more rigorous "MD/GBSA" procedure: molecular dynamics with explicit solvent for structures and a Generalized Born + Surface Area model for binding free energies. Next, we consider l-Tyr, ac- and az-Phe binding to six other TyrRS variants. The titration results are sensitive to the precise rotamer definition, which involves a short energy minimization for each sidechain pair to help relax bad contacts induced by the discrete rotamer set. However, when designed mutant structures are rescored with a standard GBSA energy model, results agree well with the more rigorous MD/GBSA. As a third test, we redesign three amino acid positions in the substrate coordination sphere, with either l-Tyr or d-Tyr as the ligand. For two, we obtain good agreement with experiment, recovering the wildtype residue when l-Tyr is the ligand and a d-Tyr specific mutant when d-Tyr is the ligand. For the third, we recover His with either ligand, instead of wildtype Gln.

  8. Design of a Nickel-Based Bond-Coat Alloy for Thermal Barrier Coatings on Copper Substrates

    Directory of Open Access Journals (Sweden)

    Torben Fiedler

    2014-11-01

    Full Text Available To increase the lifetime of rocket combustion chambers, thermal barrier coatings (TBC may be applied on the copper chamber wall. Since standard TBC systems used in gas turbines are not suitable for rocket-engine application and fail at the interface between the substrate and bond coat, a new bond-coat material has to be designed. This bond-coat material has to be chemically compatible to the copper substrate to improve the adhesion and needs a coefficient of thermal expansion close to that of copper to reduce thermal stresses. One approach to achieve this is to modify the standard NiCrAlY alloy used in gas turbines by adding copper. In this work, the influence of copper on the microstructure of NiCrAlY-alloys is investigated with thermodynamical calculations, optical microscopy, SEM, EDX and calorimetry. Adding copper leads to the formation of a significant amount of \\(\\beta\\ and \\(\\alpha\\ Reducing the aluminum and chromium content leads furthermore to a two-phase fcc microstructure.

  9. Design and optimization of coating structure for the thermal barrier coatings fabricated by atmospheric plasma spraying via finite element method

    Directory of Open Access Journals (Sweden)

    L. Wang

    2014-06-01

    Full Text Available The first prerequisite for fabricating the thermal barrier coatings (TBCs with excellent performance is to find an optimized coating structure with high thermal insulation effect and low residual stress. This paper discusses the design and optimization of a suitable coating structure for the TBCs prepared by atmospheric plasma spraying (APS using the finite element method. The design and optimization processes comply with the rules step by step, as the structure develops from a simple to a complex one. The research results indicate that the suitable thicknesses of the bond-coating and top-coating are 60–120 μm and 300–420 μm, respectively, for the single ceramic layer YSZ/NiCoCrAlY APS-TBC. The embedded interlayer (50 wt.%YSZ + 50 wt.%NiCoCrAlY will further reduce the residual stress without sacrificing the thermal insulation effect. The double ceramic layer was further considered which was based on the single ceramic layer TBC. The embedded interlayer and the upper additional ceramic layer will have a best match between the low residual stress and high thermal insulation effect. Finally, the optimized coating structure was obtained, i.e., the La2Ce2O7(LC/YSZ/Interlayer/NiCoCrAlY coating structure with appropriate layer thickness is the best choice. The effective thermal conductivity of this optimized LC/YSZ/IL/BL TBC is 13.2% lower than that of the typical single ceramic layer YSZ/BL TBC.

  10. Electro-enhanced Permeable Reactive Barrier : Optimal Design of PRB System With External Current for Effective TCE Removal From Groundwater

    Science.gov (United States)

    Moon, J.; Moon, H.; Roh, Y.; Kim, H.; Song, Y.

    2002-12-01

    The objective of this study was to design an optimal electro-enhanced permeable reactive barrier (E2PRB) system for remediation of trichloroethylene (TCE)-contaminated water using zero valent iron (ZVI) and direct current (DC). A series of column experiments were conducted to evaluate the location of Fe0 permeable reactive barrier (PRB) and the effects of electrode arrangement in the column on the TCE removal efficiency and iron corrosion processes. In twelve different combinations of ZVI and/or DC application in the test columns, the rate of reductive dechlorination of TCE was improved with simultaneous application of both ZVI and DC compared to that used ZVI only to evaluate the synergistic effect (SE). The most effective arrangement of electrode and ZVI for TCE removal from simulated groundwater was a column set with ZVI and cathode installed at the down gradient (outlet side). Based on the electrochemical study in the E2PRB system, application of direct current provided external electrons to the system so that the system did not depend entirely on the oxidation of the medium for the reductive dechlorination of TCE. The enhanced dechlorination rate of TCE in ZVI-DC systems is considered to attributed to more generation and fast formation kinetic of electron by following reactions: (1) direct supply of electrons from external DC source (2) the electrolysis of water generating additional electrons at the vicinity of the anode (3) the electro-reduction of the compound by released electrons on the ZVI surfaces by oxidation (4) released electron through oxidation of dissolved ferrous iron, and (5) oxidation of atomic hydrogen at the cathode. The competition between five different electron sources generated from five sources evidently influenced on the TCE removal efficiency, valid lifetime of E2PRB system, and reduction of energy expenditure in both of electrochemical and electrokinetic aspects. The results from a series of experiments with twelve columns showed a

  11. Research Initiatives and Preliminary Results In Automation Design In Airspace Management in Free Flight

    Science.gov (United States)

    Corker, Kevin; Lebacqz, J. Victor (Technical Monitor)

    1997-01-01

    The NASA and the FAA have entered into a joint venture to explore, define, design and implement a new airspace management operating concept. The fundamental premise of that concept is that technologies and procedures need to be developed for flight deck and ground operations to improve the efficiency, the predictability, the flexibility and the safety of airspace management and operations. To that end NASA Ames has undertaken an initial development and exploration of "key concepts" in the free flight airspace management technology development. Human Factors issues in automation aiding design, coupled aiding systems between air and ground, communication protocols in distributed decision making, and analytic techniques for definition of concepts of airspace density and operator cognitive load have been undertaken. This paper reports the progress of these efforts, which are not intended to definitively solve the many evolving issues of design for future ATM systems, but to provide preliminary results to chart the parameters of performance and the topology of the analytic effort required. The preliminary research in provision of cockpit display of traffic information, dynamic density definition, distributed decision making, situation awareness models and human performance models is discussed as they focus on the theme of "design requirements".

  12. CAS22 - FORTRAN program for fast design and analysis of shock-free airfoil cascades using fictitious-gas concept

    Science.gov (United States)

    Dulikravich, D. S.; Sobieczky, H.

    1982-01-01

    A user-oriented computer program, CAS22, was developed that is applicable to aerodynamic analysis and transonic shock-free redesign of existing two-dimensional cascades of airfoils. This FORTRAN program can be used: (1) as an analysis code for full-potential, transonic, shocked or shock-free cascade flows; (2) as a design code for shock-free cascades that uses Sobieczky's fictitious-gas concept; and (3) as a shock-free design code followed automatically by the analysis in order to confirm that the newly obtained cascade shape provides for an entirely shock-free transonic flow field. A four-level boundary-conforming grid of an O type is generated. The shock-free design is performed by implementing Sobieczky's fictitious-gas concept of elliptic continuation from subsonic into supersonic flow domains. Recomputation inside each supersonic zone is performed by the method of characteristics in the rheograph plane by using isentropic gas relations. Besides converting existing cascade shapes with multiple shocked supersonic regions into shock-free cascades, CAS22 can also unchoke previously choked cascades and make them shock free.

  13. Highlights of the ASPE 2004 Winter Topical Meeting on Free-Form Optics: Design, Fabrication, Metrology, Assembly

    Science.gov (United States)

    Ohl, Raymond G.; Dow, Thomas A.; Sohn, alex

    2004-01-01

    We present highlights from the American Society for Precision Engineering's 2004 winter topical meeting entitled Free-Form Optics: Design, Fabrication, Metrology, Assembly. We emphasize those papers that are most relevant to astronomical optics. Optical surfaces that transcend the bounds of rotational symmetry have been implemented in novel optical systems with fantastic results since the release of Polaroid's first instant camera. Despite these successes, free-form optics have found only a few niche applications and have yet to enter the mainstream. The purpose of this meeting is to identify the state of the art of free-form optics design, fabrication, metrology and assembly and to identify the technical and logistical challenges that inhibit their widespread use. Issues that will be addressed include: What are free-form optics? How can optical systems be made better with free-form optics? How can designers use free-form optics? How can free-form optics be fabricated? How can they be measured? How are free-form optical systems assembled? Control of multi-axis systems.

  14. Dynamics Modeling and first Design of Drag-Free Controller for ASTROD I

    Science.gov (United States)

    Li, H.; Theil, S.; Pettazzi, L.; Guilherme, M.-S.; Ni, W.-T.

    The Astrodynamical Space Test of Relativity using Optical Devices I ASTROD I mainly aims at testing relativistic gravity and measuring the solar-system parameters with high precision by carrying out laser ranging between a spacecraft in a solar orbit and ground stations It is the first step of ASTROD with 3 spacecraft In order to design the Drag-Free and Attitude Control system DFACS for the spacecraft a numerical simulator of spacecraft and test mass dynamics as well as models of main forces and torques are established using Matlab Simulink The aims of the DFACS are to reduce the acceleration disturbance on the test mass to a level of 10 -13 m cdot s -2 cdot Hz -1 2 at a frequency of 0 1 mHz in one axis and keep the telescope pointing to the ground stations on the earth The dynamics of spacecraft and test mass is a coupled multiple degree of freedom non-linear system So the first step of the DFACS design is to reduce the order of the system with assumptions without loss of generality Then the system is linearized at nominal state With the linear state space model of the system a Linear Quadratic Gaussian Regulator LQG is derived LQR and the feed-forward of a constant disturbance constitute the controller This paper will present the numerical simulator and the first drag-free controller design for ASTROD I It will show the development of the simulator the derivation of the controller as well as first simulation results

  15. Incorporation of a barrier protection cream in the management of chronic hand dermatitis: focus on data supporting an established hand protectant formulation and modifications designed to assist in barrier repair.

    Science.gov (United States)

    Del Rosso, James Q

    2014-02-01

    overview of hand dermatitis, reviews data supporting the therapeutic benefit of a specific barrier protection hand cream, and discusses ingredient modifications to the original formulation. The newer formulation does not alter the skin barrier protection components; however, the new ingredients were selected to add barrier repair properties to the original product, which was designed only as a skin barrier protectant.

  16. Permanent isolation surface barrier development plan

    International Nuclear Information System (INIS)

    The exhumation and treatment of wastes may not always be the preferred alternative in the remediation of a waste site. In-place disposal alternatives, under certain circumstances, may be the most desirable alternatives to use in the protection of human health and the environment. The implementation of an in-place disposal alternative will likely require some type of protective covering that will provide long-term isolation of the wastes from the accessible environment. Even if the wastes are exhumed and treated, a long-term barrier may still be needed to adequately dispose of the treated wastes or any remaining waste residuals. Currently, no open-quotes provenclose quotes long-term barrier is available. The Hanford Site Permanent Isolation Surface Barrier Development Program (BDP) was organized to develop the technology needed to provide a long-term surface barrier capability for the Hanford Site. The permanent isolation barrier technology also could be used at other sites. Permanent isolation barriers use engineered layers of natural materials to create an integrated structure with redundant protective features. Drawings of conceptual permanent isolation surface barriers are shown. The natural construction materials (e.g., fine soil, sand, gravel, riprap, asphalt) have been selected to optimize barrier performance and longevity. The objective of current designs is to use natural materials to develop a maintenance-free permanent isolation surface barrier that isolates wastes for a minimum of 1,000 years by limiting water drainage to near-zero amounts; reducing the likelihood of plant, animal, and human intrusion; controlling the exhalation of noxious gases; and minimizing erosion-related problems

  17. Permanent isolation surface barrier development plan

    Energy Technology Data Exchange (ETDEWEB)

    Wing, N.R.

    1994-01-01

    The exhumation and treatment of wastes may not always be the preferred alternative in the remediation of a waste site. In-place disposal alternatives, under certain circumstances, may be the most desirable alternatives to use in the protection of human health and the environment. The implementation of an in-place disposal alternative will likely require some type of protective covering that will provide long-term isolation of the wastes from the accessible environment. Even if the wastes are exhumed and treated, a long-term barrier may still be needed to adequately dispose of the treated wastes or any remaining waste residuals. Currently, no {open_quotes}proven{close_quotes} long-term barrier is available. The Hanford Site Permanent Isolation Surface Barrier Development Program (BDP) was organized to develop the technology needed to provide a long-term surface barrier capability for the Hanford Site. The permanent isolation barrier technology also could be used at other sites. Permanent isolation barriers use engineered layers of natural materials to create an integrated structure with redundant protective features. Drawings of conceptual permanent isolation surface barriers are shown. The natural construction materials (e.g., fine soil, sand, gravel, riprap, asphalt) have been selected to optimize barrier performance and longevity. The objective of current designs is to use natural materials to develop a maintenance-free permanent isolation surface barrier that isolates wastes for a minimum of 1,000 years by limiting water drainage to near-zero amounts; reducing the likelihood of plant, animal, and human intrusion; controlling the exhalation of noxious gases; and minimizing erosion-related problems.

  18. Conceptual design of free-piston Stirling conversion system for solar power units

    Science.gov (United States)

    Loktionov, Iu. V.

    A conversion system has been conceptually designed for solar power units of the dish-Stirling type. The main design objectives were to demonstrate the possibility of attaining such performance characteristics as low manufacturing and life cycle costs, high reliability, long life, high efficiency, power output stability, self-balance, automatic (or self-) start-up, and easy maintenance. The system design includes a heat transfer and utilization subsystem with a solar receiver, a free-piston engine, an electric power generation subsystem, and a control subsystem. The working fluid is helium. The structural material is stainless steel for hot elements, aluminum alloys and plastics for others. The electric generation subunit can be fabricated in three options: with an induction linear alternator, with a permanent magnet linear alternator, and with a serial rotated induction generator and a hydraulic drive subsystem. The heat transfer system is based on heat pipes or the reflux boiler principle. Several models of heat transfer units using a liquid metal (Na or Na-K) have been created and demonstrated.

  19. Prediction of free air space in initial composting mixtures by a statistical design approach.

    Science.gov (United States)

    Soares, Micaela A R; Quina, Margarida J; Quinta-Ferreira, Rosa

    2013-10-15

    Free air space (FAS) is a physical parameter that can play an important role in composting processes to maintain favourable aerobic conditions. Aiming to predict the FAS of initial composting mixtures, specific materials proportions ranged from 0 to 1 were tested for a case study comprising industrial potato peel, which is characterized by low air void volume, thus requiring additional components for its composting. The characterization and prediction of FAS for initial mixtures involving potato peel, grass clippings and rice husks (set A) or sawdust (set B) was accomplished by means of an augmented simplex-centroid mixture design approach. The experimental data were fitted to second order Scheffé polynomials. Synergistic or antagonistic effects of mixture proportions in the FAS response were identified from the surface and response trace plots in the FAS response. Moreover, a good agreement was achieved between the model predictions and supplementary experimental data. Moreover, theoretical and empirical approaches for estimating FAS available in literature were compared with the predictions generated by the mixture design approach. This study demonstrated that the mixture design methodology can be a valuable tool to predict the initial FAS of composting mixtures, specifically in making adjustments to improve composting processes containing primarily potato peel.

  20. A checklist for designers of cryogen-free MgB{sub 2} coils

    Energy Technology Data Exchange (ETDEWEB)

    Stenvall, A [Institute of Electromagnetics, Tampere University of Technology, PO Box 692, 33101 Tampere (Finland); Hiltunen, I [Institute of Electromagnetics, Tampere University of Technology, PO Box 692, 33101 Tampere (Finland); Korpela, A [Institute of Electromagnetics, Tampere University of Technology, PO Box 692, 33101 Tampere (Finland); Lehtonen, J [Institute of Electromagnetics, Tampere University of Technology, PO Box 692, 33101 Tampere (Finland); Mikkonen, R [Institute of Electromagnetics, Tampere University of Technology, PO Box 692, 33101 Tampere (Finland); Viljamaa, J [Prizztech Ltd, Magnet Technology Centre, Technology Centre Pripoli, Tiedepuisto 4, 28600 Pori (Finland); Grasso, G [Columbus Superconductors, Corso Perrone 24, I-16152 Genova (Italy)

    2007-04-15

    Intensive research has been directed at MgB{sub 2} since its discovery in 2001, focusing first on the material properties and conductor development and recently also on coil demonstrations. The relatively cheap and easy fabrication makes MgB{sub 2} a tempting material for superconducting applications. It can also be operated in the vicinity of 20 K, at which the commercial LTS materials are still in the normal state. However, commercial breakthrough requires practical applications and demonstrations. Therefore, we built a solenoidal react-and-wind MgB{sub 2} coil consisting of 46 m of commercially available MgB{sub 2} /Ni/Fe/Cu tape manufactured by Columbus Superconductors. We tested the coil in a cryogen-free environment and measured the effect of repeated cooldowns and current ramp rate on the coil critical current. Also, temperature homogeneity in the winding was studied. Based on the test results we point out features which should be checked when cryogen-free magnet systems are designed or their performance is discussed. For example, the coil critical current and n value can depend notably on the current ramp rate.

  1. Designing a Beryllium-Free Deep-Ultraviolet Nonlinear Optical Material without a Structural Instability Problem.

    Science.gov (United States)

    Zhao, Sangen; Kang, Lei; Shen, Yaoguo; Wang, Xiaodong; Asghar, Muhammad Adnan; Lin, Zheshuai; Xu, Yingying; Zeng, Siyuan; Hong, Maochun; Luo, Junhua

    2016-03-01

    A beryllium-free deep-ultraviolet (deep-UV) nonlinear optical (NLO) material K3Ba3Li2Al4B6O20F is developed mainly by the element substitution of Be for Al and Li from Sr2Be2B2O7 that was considered as one of the most promising deep-UV NLO materials. K3Ba3Li2Al4B6O20F preserves the structural merits of Sr2Be2B2O7 and thus exhibits no layering growth tendency and possesses the optical properties required for deep-UV NLO applications, including deep-UV transparency, phase-matchability, and sufficiently large second-harmonic generation (1.5 × KH2PO4). Furthermore, it overcomes the structural instability problem of Sr2Be2B2O7, which is confirmed by the obtainment of large single crystals and phonon dispersion calculations. These attributes make it very attractive for next-generation deep-UV NLO materials. The substitution of Be for Al and Li in beryllium borates provides a new opportunity to design beryllium-free deep-UV NLO materials with good performance. PMID:26889570

  2. Barriers to radiant barriers

    Energy Technology Data Exchange (ETDEWEB)

    Henke, C.

    Radiant barriers are an energy saving device which decrease the heat lost through radiant heat transfer. The primary reason to install it is to save on air conditioning costs, as it prevents the loss of heat through the attic. They have been the subject of much controversy, as the claims made by many manufacturers were extreme (up to 100% heat shielding), with the consumer paying high prices for ineffective devices. The authors outline criteria for the consumer to consider when buying radiant warmers and then give installation tips for both new constructions and retrofits.

  3. Design of a holographic tracking module for long-range retroreflector free-space systems.

    Science.gov (United States)

    Quintana, C; Erry, G; Gomez, A; Thueux, Y; Faulkner, G E; O'Brien, D C

    2016-09-01

    Weight reduction and low power consumption are key requirements in the next generation of unmanned aerial vehicles (UAVs). To communicate with an operator, a secured link between the UAV and a ground-based station is desirable. To realize these links, retroreflecting free-space optics is potentially attractive as it offers light weight and low complexity at the UAV. However, the base station requires a high-performance tracking module to enable a steady illumination of the UAV retroreflector. In this paper, we present the design and implementation of a tracking system, which consists of coarse tracking and holographic fine tracking modules working cooperatively. Using this system, experimental field trials were carried out by mounting a multiple-quantum-well-based modulated retroreflector on a commercial UAV. A 2 Mbps optical link was achieved with a bit error rate of ∼2×10-4 at a link range of 300 m. PMID:27607298

  4. Design of a holographic tracking module for long-range retroreflector free-space systems.

    Science.gov (United States)

    Quintana, C; Erry, G; Gomez, A; Thueux, Y; Faulkner, G E; O'Brien, D C

    2016-09-01

    Weight reduction and low power consumption are key requirements in the next generation of unmanned aerial vehicles (UAVs). To communicate with an operator, a secured link between the UAV and a ground-based station is desirable. To realize these links, retroreflecting free-space optics is potentially attractive as it offers light weight and low complexity at the UAV. However, the base station requires a high-performance tracking module to enable a steady illumination of the UAV retroreflector. In this paper, we present the design and implementation of a tracking system, which consists of coarse tracking and holographic fine tracking modules working cooperatively. Using this system, experimental field trials were carried out by mounting a multiple-quantum-well-based modulated retroreflector on a commercial UAV. A 2 Mbps optical link was achieved with a bit error rate of ∼2×10-4 at a link range of 300 m.

  5. PVDF core-free actuator for Braille displays: design, fabrication process, and testing

    Science.gov (United States)

    Levard, Thomas; Diglio, Paul J.; Lu, Sheng-Guo; Gorny, Lee J.; Rahn, Christopher D.; Zhang, Q. M.

    2011-04-01

    Refreshable Braille displays require many, small diameter actuators to move the pins. The electrostrictive P(VDF-TrFECFE) terpolymer can provide the high strain and actuation force under modest electric fields that are required of this application. In this paper, we develop core-free tubular actuators and integrate them into a 3 × 2 Braille cell. The films are solution cast, stretched to 6 μm thick, electroded, laminated into a bilayer, rolled into a 2 mm diameter tube, bonded, and provided with top and bottom contacts. Experimental testing of 17 actuators demonstrates significant strains (up to 4%). A novel Braille cell is designed and fabricated using six of these actuators.

  6. Design of the miniaturized free electron laser module as an efficient source of the THz waves

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Chul [Department of Optometry, Eulji University, 212 Yangji-dong, Sujeong-gu, Seongnam-si, Gyeonggi-do 461-713 (Korea, Republic of); Ahn, Seong Joon [Department of I and C Engineering, Sun Moon University, Tangjeong-myeon, Asan-si, Chungnam 336-708 (Korea, Republic of); Kim, Ho Seob; Kim, Dae-Wook [Department of Information Display, Sun Moon University, 100 Kalsan-ri, Tangjeong-myun, Asan-si, Chungnam 336-708 (Korea, Republic of); Ahn, Seungjoon, E-mail: sjan@sunmoon.ac.kr [Department of Information Display, Sun Moon University, 100 Kalsan-ri, Tangjeong-myun, Asan-si, Chungnam 336-708 (Korea, Republic of)

    2011-10-21

    Since the tremendous potential of the THz wave for the bio-technological applications has been found, there has been a lot of interest paid to development of the THz-wave sources. The miniaturized free electron laser (FEL) module based on the microcolumn can be a very convenient THz wave emitter because of its compactness. In this work, we tried to design the miniaturized FEL module to achieve the optimized electron beam (e-beam) trajectory in the module by using 3D simulation tool. We found that the accelerator bias, the length and radius of the limiting aperture were important parameters to obtain the strong and parallel e-beam. We have also proposed the ring-type grids to get more symmetrical behavior of the e-beam in the wiggler.

  7. Scaling laws for free piston Stirling engine design: Benefits and challenges of miniaturization

    International Nuclear Information System (INIS)

    This work explores the scaling effects for FPSE (free piston Stirling engines), which are known for their simple architecture and potentially high thermodynamic performances. Scaling laws are given and their potential for miniaturization is highlighted. A simple model which allows the design of the geometrical parameters of the heat exchangers, the regenerator and the masses of the pistons is proposed. It is based on the definition of six characteristic dimensionless groups. They are derived from the physics underlying the behavior of the free piston Stirling machine and their relevancy is backed up by comparisons between documented Stirling engines from the literature. Keeping constant values for each group throughout the scaling range theoretically ensures constant performance. The main losses of Stirling engine (heat conduction loss, reheat loss in the regenerator, pressure drop and gas-spring hysteresis) can be expressed as a function of the geometrical and operating parameters. Additionally, the consequences of leakage due to the manufacturing precision of pistons architectures are underlined. From the proposed scaling laws, potential power and efficiency of Stirling cycle engines at a millimeter scale can be anticipated. It appears that the power density increases with miniaturization. It is also shown that the dynamic masses related to the engine size are increased when scaling down and that the gap leakage presents the highest detrimental effects on the efficiency. These results call for dedicated architectures for micro-engines. - Highlights: • Similitude strategy is applied to Stirling engines and allows preliminary design. • New scaling laws are derived. • The power density can be increased with miniaturization. • The gap between the piston and casing is highly detrimental to the performances. • High engine operating pressure is required when miniaturizing

  8. 城市地面道路声屏障设计研究%Study on Noise Barriers Design for City Ground Road

    Institute of Scientific and Technical Information of China (English)

    路晓东; 唐建; 蔡军

    2012-01-01

    不同于欧美各国,作为交通噪声防治的主要措施,我国声屏障主要用于高架路,城市地面道路应用很少.随着交通噪声增加,城市地面道路声屏障亟需重视,其设计约束多,难度大,问题复杂,需在规划前期便开始着手考虑.该文结合欧美各国及香港地区的实例,总结声屏障设计的四种方式,即与道路设计结合,与场地设计结合,与建筑设计结合,与视觉效果结合,为交通噪声防治提供借鉴.%As the main measures of traffic noise prevention, unlike Europe and the United States, noise barrier in China is mainly used for the elevated road, while seldom for ground road. With the increase of traffic noise, the noise barrier for city ground road urgently needs to be paid attention. In the planning phase, it needs to be considered because of design constraints, difficulty and complexity. Combining with the European and American examples, the paper summarizes four ways to set the sound barrier in planning phase ,and provides a reference for traffic noise prevention, for example road barrier design combined with road design, site design, architectural design, aesthetics effert and so on.

  9. Reserch on building fire barrier design of nuclear power plants%核电厂建筑防火分隔设计的研究

    Institute of Scientific and Technical Information of China (English)

    邱爽; 丛佩生; 殷海洋

    2015-01-01

    During the compiling,the concept of fire barrier is the core content of building part in the national standard of Code for Design of Fire Protection for Conventional Island in Nuclear Power Plants(GB 50745—2012). The concept of fire barrier is the core content from the generation and definition of the concept of fire barrier,to make a detailed explanation and analysis on understanding and application in building fire protec-tion design of nuclear power plants. The proposing of the new design concept has an important significance for guiding the building fire protection design of nuclear power plants.%指出建筑防火分隔概念是国家标准GB 50745—2012核电厂常规岛设计防火规范编制过程中建筑部分的核心内容,就防火分隔概念的产生、定义以及在核电厂建筑防火设计中的理解和如何运用进行了详细解释和分析,新设计概念的提出对于指导核电厂建筑消防设计具有重要意义。

  10. An infrared free-electron laser for the Chemical Dynamics Research Laboratory. Design report

    Energy Technology Data Exchange (ETDEWEB)

    Vaughan, D. [comp.

    1992-04-01

    This document describes a free-electron laser (FEL) proposed as part of the Chemical Dynamics Research Laboratory (CDRL), a user facility that also incorporates several advanced lasers of conventional design and two beamlines for the ALS. The FEL itself addresses the needs of the chemical sciences community for a high-brightness, tunable source covering a broad region of the infrared spectrum -- from 3 to 50 {mu}m. All of these sources, together with a variety of sophisticated experimental stations, will be housed in a new building to be located adjacent to the ALS. The radiation sources can be synchronized to permit powerful two-color, pump-probe experiments that will further our fundamental understanding of chemical dynamics at the molecular level, especially those aspects relevant to practical issues in combustion chemistry. The technical approach adopted in this design makes use of superconducting radiofrequency (SCRF) accelerating structures. The primary motivation for adopting this approach was to meet the user requirement for wavelength stability equal to one part in 10{sup 4}. Previous studies concluded that a wavelength stability of only one part in 10{sup 3} could be achieved with currently available room-temperature technology. In addition, the superconducting design operates in a continuous-wave (cw) mode and hence offers considerably higher average optical output power. It also allows for various pulse-gating configurations that will permit simultaneous multiuser operations. A summary of the comparative performance attainable with room-temperature and superconducting designs is given. The FEL described in this report provides a continuous train of 30-ps micropulses, with 100{mu}J of optical energy per micropulse, at a repetition rate of 6.1 MHz. The device can also deliver pulses at a cw repetition rate of 12.2 MHz, with a peak power of 50 {mu}J per micropulse. 70 ref.

  11. Computational Sampling and Simulation Based Assessment of Novel Mycobacterium tuberculosis Glutamine Synthetase Inhibitors: Study Involving Structure Based Drug Design and Free Energy Perturbation.

    Science.gov (United States)

    Suryadevara, Priyanka; Yogeeswari, Perumal; Soni, Vijay; Devi, Parthiban Brindha; Nandicoori, Vinay Kumar; Sriram, Dharmarajan

    2016-01-01

    The highly persistent nature of Mycobacterium tuberculosis can be attributed to its lipophilic cell wall which acts as a major barrier in the process of drug discovery against tuberculosis. Glutamine synthetase plays a major role in nitrogen metabolism and cell wall biosynthesis of pathogenic mycobacteria. The current review focuses on the structural and functional aspects of Mtb glutamine synthetase and an overview of its reported inhibitors till date. Also in the present study, we employed a computational structure based drug design protocol for identifying novel inhibitors against Mtb glutamine synthetase (MtbGS). A total of 12 hits were identified based on e-pharmacophore related search and virtual screening, which were further tested for their in vitro MtbGS inhibitory activity. Three compounds (compound 6, 1 and 12) were found with IC50 less than 5 µM, of which compound 6 being top active with IC50 of 2.124 µM. Differential scanning fluorimetry studies were employed so as to measure the thermal stability of the protein complexed with the most active compound. Also the protein complexes with top three active compounds were subjected for molecular dynamics simulations to study their binding pattern and stabilization effect. The solvation free energies were also determined for these compounds, undertaking free energy perturbation studies, which can be used further for lead optimization in the process of anti-tubercular drug discovery targeting Mtb glutamine synthetase.

  12. Hanford Permanent Isolation Barrier Program: Asphalt technology test plan

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, H.D.; Romine, R.A.

    1994-05-01

    The Hanford Permanent Isolation Barriers use engineered layers of natural materials to create an integrated structure with backup protective features. The objective of current designs is to develop a maintenance-free permanent barrier that isolates wastes for a minimum of 1000 years by limiting water drainage to near-zero amounts. Asphalt is being used as an impermeable water diversion layer to provide a redundant layer within the overall barrier design. Data on asphalt barrier properties in a buried environment are not available for the required 100-year time frame. The purpose of this test plan is to outline the activities planned to obtain data with which to estimate performance of the asphalt layers.

  13. Hanford Permanent Isolation Barrier Program: Asphalt technology test plan

    International Nuclear Information System (INIS)

    The Hanford Permanent Isolation Barriers use engineered layers of natural materials to create an integrated structure with backup protective features. The objective of current designs is to develop a maintenance-free permanent barrier that isolates wastes for a minimum of 1000 years by limiting water drainage to near-zero amounts. Asphalt is being used as an impermeable water diversion layer to provide a redundant layer within the overall barrier design. Data on asphalt barrier properties in a buried environment are not available for the required 100-year time frame. The purpose of this test plan is to outline the activities planned to obtain data with which to estimate performance of the asphalt layers

  14. Electrochemomechanical deformation (ECMD) of PPyDBS in free standing film formation and trilayer designs

    Science.gov (United States)

    Aydemir, Nihan; Tamm, Tarmo; Travas-Sejdic, Jadranka; Kilmartin, Paul A.; Aabloo, Alvo; Kiefer, Rudolf

    2014-03-01

    An investigation is reported into the electrochemomechanical deformation (ECMD) of polypyrrole (PPy) doped with dodecylbenzenesulfonate (DBS) in the form of freestanding films and deposited onto conductive substrates (chemically fixed poly-3,4-(ethylenedioxythiophene, PEDOT) based on PVdF (poly(vinylidenefluoride)). Linear actuation has been achieved starting from a trilayer bending actuator design with a stretchable middle layer. To allow evaluation of the proposed design, commercially available PVdF membranes were chosen as model material. For bending trilayer functionality, electronic separation of both electrode layers is essential, but in order to obtain linear actuation, the CP layers on either side are connected to form a single working electrode. The PPyDBS free standing films and PPyDBS deposited on PEDOT-PVdF-PEDOT were investigated by electrochemical methods (cyclic voltammetry, square wave potentials) in a 4-methyl-1,3-dioxolan-2-one (propylene carbonate, PC) solution of tetrabutylammonium trifluoromethanesulfonate (TBACF3SO3). This study also presents a novel method of utilizing scanning ion-conductance microscopy (SICM) to accurately examine the electrochemical redox behavior of the surface layer of the linear actuator using a micropipette tip.

  15. Design New Intelligent-Base Chattering Free Nonlinear Control of Spherical Motor

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Tayebi

    2014-09-01

    Full Text Available The main four objectives to design controllers are: stability, robust, minimum error and reliability. Linear PID controller is model-free controller and this controller is not reliable. One of the robust nonlinear controller to control of nonlinear systems is sliding mode controller (SMC. Sliding mode controller (SMC is robust conventional nonlinear controller in a partly uncertain dynamic system’s parameters. Sliding mode controller is divided into two main sub parts: discontinues controller〖(τ〗_dis and equivalent controller〖(τ〗_eq. Discontinues controller is used to design suitable tracking performance based on very fast switching. Fast switching or discontinuous part have essential role to achieve to good trajectory following, but it is caused system instability and chattering phenomenon. Chattering phenomenon is one of the main challenges in conventional sliding mode controller and it can causes some important mechanical problems such as saturation and heats the mechanical parts of robot manipulators or drivers. To reduce or eliminate the chattering two methods are used in many researches which these methods are: boundary layer saturation method and artificial intelligence based method. In this research fuzzy switching methodology is used to eliminate the chattering in presence of uncertainty to increase the robust of this controller with application to three dimensions of spherical motor.

  16. Conceptual design of a high-power infrared free electron laser for the applications in nuclear industry

    International Nuclear Information System (INIS)

    Free electron lasers are tuneable over a wide-range of spectrum, and can generate high aver power of laser beam. The free electron lasers can be used in many fields of nuclear industry such as production of heavy water, extraction of tritium from heavy water, production of isotopes for medical and industrial applications, partioning and extraction of valuable elements from nuclear waste, and so on. In this paper, the conceptual design of a high average power infrared free electron laser for the application in nuclear industry is described. The tunable range of output wavelength of the free electron laser is 1-30 μm, and the average power is 10-100 kW. A 100-MeV recirculating RF accelerator with energy recovery will be used as a driver of the free electron laser. Details of the electron accelerator, optical cavity, undulator, etc. are described in this paper

  17. Durability and Design Issues of Thermal/environmental Barrier Coatings on Sic/sic Ceramic Matrix Composites Under 1650 C Test Conditions

    Science.gov (United States)

    Zhu, Dong-Ming; Choi, Sung R.; Ghosn, Louis J.; Miller, Robert A.

    2004-01-01

    Ceramic thermal/environmental barrier coatings for SiC-based ceramics will play an increasingly important role in future gas turbine engines because of their ability to effectively protect the engine components and further raise engine temperatures. However, the coating durability remains a major concern with the ever-increasing temperature requirements. Currently, advanced T/EBC systems, which typically include a high temperature capable zirconia- (or hahia-) based oxide top coat (thermal barrier) on a less temperature capable mullite/barium-strontium-aluminosilicate (BSAS)/Si inner coat (environmental barrier), are being developed and tested for higher temperature capability Sic combustor applications. In this paper, durability of several thermal/environmental barrier coating systems on SiC/SiC ceramic matrix composites was investigated under laser simulated engine thermal gradient cyclic, and 1650 C (3000 F) test conditions. The coating cracking and delamination processes were monitored and evaluated. The effects of temperature gradients and coating configurations on the ceramic coating crack initiation and propagation were analyzed using finite element analysis (FEA) models based on the observed failure mechanisms, in conjunction with mechanical testing results. The environmental effects on the coating durability will be discussed. The coating design approach will also be presented.

  18. Design of cascading two stages of high gain harmonic generation scheme based on Shanghai deep ultraviolet free electron laser

    Institute of Scientific and Technical Information of China (English)

    DENG Hai-Xiao; DAI Zhi-Min

    2008-01-01

    Cascading stages of high gain harmonic generation free electron laser (FEL) seem to be a feasible way to generate short wavelength radiation. With help of the analytical estimates, we design a two-stage cascading scheme to achieve 131 nm DUV radiation on the basis of the Shanghai deep ultraviolet free electron laser test facility. Detailed studies on the FEL performance, the stability and the sensitivity of the output power to parameter variation have been achieved by GENESIS1.3, and design of the lattice structure is presented.

  19. Investigating the design and application of a funnel and gate barrier for PCB remediation in the Canadian Arctic

    Energy Technology Data Exchange (ETDEWEB)

    Kalinovich, I.; Rowe, R.K. [Queen' s Univ., Kingston, ON (Canada). Dept. of Civil Engineering]|[Royal Military Coll. of Canada, Kingston, ON (Canada); Rutter, A.; Poland, J. [Queen' s Univ., Kingston, ON (Canada). Dept. of Environmental Engineering; McWatters, R. [Queen' s Univ., Kingston, ON (Canada)

    2004-07-01

    A long-term remediation plan is underway at a former military radar base at Resolution Island, Nunavut to prevent the migration of soils contaminated with polychlorinated biphenyls (PCBs) from entering the drainage pathways of the island and flowing into the ocean. Migration pathways for PCBs include: leaching from soil; becoming mobilized via runoff; and, dispersed as an aerosol into the atmosphere. This study examined the feasibility of using geosynthetics as filters and sorbents in a funnel and gate barrier system. Preliminary results from a field trial were reported. The main concern was to determine how the geosynthetics will perform in the harsh Arctic conditions. In addition to field studies, laboratory studies examined the changes in permittivity in geosynthetics that have been exposed to ultraviolet (UV) and freeze-thaw conditions. Different geosynthetic materials, including filters and adsorbents, were also examined to determine if an isotherm can be established and used to evaluate sorption kinetics. The funnel and gate barrier system currently installed at the site is working as expected. The barrier system traps PCBs in a short period of time and the geosynthetic boom is an excellent adsorbent of PCBs. However, the permeability of the barrier materials seem to be affected by freeze-thaw and UV effects. 17 refs., 2 tabs., 1 fig.

  20. Design Studies for a VUV--Soft X-ray Free-Electron Laser Array

    International Nuclear Information System (INIS)

    Several recent reports have identified the scientific requirements for a future soft X-ray light source, and a high-repetition-rate free-electron laser (FEL) facility responsive to them is being studied at Lawrence Berkeley National Laboratory (LBNL). The facility is based on a continuous-wave (CW) superconducting linear accelerator with beam supplied by a high-brightness, high-repetition-rate photocathode electron gun operating in CW mode, and on an array of FELs to which the accelerated beam is distributed, each operating at high repetition rate and with even pulse spacing. Dependent on the experimental requirements, the individualFELs may be configured for either self-amplified spontaneous emission (SASE), seeded highgain harmonic generation (HGHG), echo-enabled harmonic generation (EEHG), or oscillator mode of operation, and will produce high peak and average brightness x-rays with a flexible pulse format ranging from sub-femtoseconds to hundreds of femtoseconds. This new light source would serve a broad community of scientists in many areas of research, similar to existing utilization of storage ring based light sources. To reduce technical risks and constructioncosts, accelerator research, development, and design studies at LBNL target the most critical components and systems of the facility. We are developing a high-repetition-rate low-emittance electron gun, high quantum efficiency photocathodes, and have embarked on design and optimization of the electron beam accelerator, FEL switchyard, and array of FELs. We continue our work on precision timing and synchronization systems critical for time-resolved experiments using pump-probe techniques.

  1. Distortion-free spectrum sliced microwave photonic signal processor: analysis, design and implementation.

    Science.gov (United States)

    Li, Liwei; Yi, Xiaoke; Huang, Thomas X H; Minasian, Robert A

    2012-05-01

    A new switchable microwave photonic filter based on a novel spectrum slicing technique is presented. The processor enables programmable multi-tap generation with general transfer function characteristics and offers tunability, reconfigurabiliy, and switchability. It is based on connecting a dispersion controlled spectrum slicing filter after the modulated bipolar broadband light source, which consequently generates multiple spectrum slices with bipolarity, and compensates dispersion induced RF degradation simultaneously within a single device. A detailed theoretical model for this microwave photonic filter design is presented. Experimental results are presented which verify the model, and demonstrate a 33 bipolar-tap microwave filter with significant reduction of passband attenuations at high frequencies. The RF response improvement of the new microwave photonic filter is investigated, for both an ideal linear group delay line and for the experimental fiber delay line that has second order group delay and the results show that this new structure is effective for RF filters with various free spectral range values and spectrum slice bandwidths. Finally, a switchable bipolar filter that has a square-top bandpass filter response with more than 30 dB stopband attenuation that can be switched on/off via software control is demonstrated. PMID:22565771

  2. Distortion-free spectrum sliced microwave photonic signal processor: analysis, design and implementation.

    Science.gov (United States)

    Li, Liwei; Yi, Xiaoke; Huang, Thomas X H; Minasian, Robert A

    2012-05-01

    A new switchable microwave photonic filter based on a novel spectrum slicing technique is presented. The processor enables programmable multi-tap generation with general transfer function characteristics and offers tunability, reconfigurabiliy, and switchability. It is based on connecting a dispersion controlled spectrum slicing filter after the modulated bipolar broadband light source, which consequently generates multiple spectrum slices with bipolarity, and compensates dispersion induced RF degradation simultaneously within a single device. A detailed theoretical model for this microwave photonic filter design is presented. Experimental results are presented which verify the model, and demonstrate a 33 bipolar-tap microwave filter with significant reduction of passband attenuations at high frequencies. The RF response improvement of the new microwave photonic filter is investigated, for both an ideal linear group delay line and for the experimental fiber delay line that has second order group delay and the results show that this new structure is effective for RF filters with various free spectral range values and spectrum slice bandwidths. Finally, a switchable bipolar filter that has a square-top bandpass filter response with more than 30 dB stopband attenuation that can be switched on/off via software control is demonstrated.

  3. Testing VHF/GPS Collar Design and Safety in the Study of Free-Roaming Horses

    OpenAIRE

    Collins, Gail H.; Petersen, Steven L.; Carr, Craig A.; Leon Pielstick

    2014-01-01

    Effective and safe monitoring techniques are needed by U.S. land managers to understand free-roaming horse behavior and habitat use and to aid in making informed management decisions. Global positioning system (GPS) and very high frequency (VHF) radio collars can be used to provide high spatial and temporal resolution information for detecting free-roaming horse movement. GPS and VHF collars are a common tool used in wildlife management, but have rarely been used for free-roaming horse resear...

  4. Optimizing Design Efficiency of Free Recall Events for fMRI

    OpenAIRE

    Öztekin, Ilke; Long, Nicole M.; Badre, David

    2010-01-01

    Free recall is a fundamental paradigm for studying memory retrieval in the context of minimal cue support. Accordingly, free recall has been extensively studied using behavioral methods. However, the neural mechanisms that support free recall have not been fully investigated due to technical challenges associated with probing individual recall events with neuroimaging methods. Of particular concern is the extent to which the uncontrolled latencies associated with recall events can confer suff...

  5. Design and operation of an inverse free-electron-laser accelerator in the microwave regime

    Science.gov (United States)

    Yoder, Rodney Bruce

    2000-09-01

    A novel electron accelerator demonstrating the inverse free-electron-laser (IFEL) principle has been designed, built, and operated using radio-frequency power at 2.856 GHz. Such an accelerator uses a stationary, periodic magnetic field to impart transverse motion to charged particles, which are then accelerated by guided electromagnetic waves. The experiment described here demonstrates for the first time the phase dependence of IFEL acceleration. This design uses up to 15 MW of RF power propagating in a smooth-walled circular waveguide surrounded by a pulsed bifilar helical undulator; an array of solenoids provides an axial guiding magnetic field undulator; pitch, which is initially 11.75 cm, is linearly increased to 12.3 cm. over the 1-meter length of the structure to maintain acceleration gradient. Numerical computations predict an energy gain of up to 0.7 MeV using a 6 MeV injected beam from a 2-1/2 cell RF gun, with small energy spread and strong phase trapping. The initial injection phase is the most important parameter, determining the rate of energy gain or loss. These simulations are compared with experimental measurements at low power in which electron beams at energies between 5 and 6 MeV gain up to 0.35 MeV with minimal energy spread, all exiting particles having been accelerated. The predicted phase sensitivity of the mechanism is verified, with beams injected into accelerating phases gaining energy cleanly while those injected into ``decelerating'' phases are shown to be degraded in quality and hardly changed in energy, demonstrating the asymmetry of a tapered-wiggler design. Agreement with simulation is very good for accelerating phases, though less exact otherwise. Scaling to higher power and frequency is investigated. The maximum attainable acceleration gradient for a MIFELA using 150 MW of RF power at 34 GHz is estimated to be at least 30 MV/m, and laser IFELs could conceivably reach gradients in the GeV/m range.

  6. Conceptual design of a laser-plasma accelerator driven free-electron laser demonstration experiment

    International Nuclear Information System (INIS)

    Up to now, short-wavelength free-electron lasers (FEL) have been systems on the scale of hundreds of meters up to multiple kilometers. Due to the advancements in laser-plasma acceleration in the recent years, these accelerators have become a promising candidate for driving a fifth-generation synchrotron light source - a lab-scale free-electron laser. So far, demonstration experiments have been hindered by the broad energy spread typical for this type of accelerator. This thesis addresses the most important challenges of the conceptual design for a first lab-scale FEL demonstration experiment using analytical considerations as well as simulations. The broad energy spread reduces the FEL performance directly by weakening the microbunching and indirectly via chromatic emittance growth, caused by the focusing system. Both issues can be mitigated by decompressing the electron bunch in a magnetic chicane, resulting in a sorting by energies. This reduces the local energy spread as well as the local chromatic emittance growth and also lowers performance degradations caused by the short bunch length. Moreover, the energy dependent focus position leads to a focus motion within the bunch, which can be synchronized with the radiation pulse, maximizing the current density in the interaction region. This concept is termed chromatic focus matching. A comparison shows the advantages of the longitudinal decompression concept compared to the alternative approach of transverse dispersion. When using typical laser-plasma based electron bunches, coherent synchrotron radiation and space-charge contribute in equal measure to the emittance growth during decompression. It is shown that a chicane for this purpose must not be as weak and long as affordable to reduce coherent synchrotron radiation, but that an intermediate length is required. Furthermore, the interplay of the individual concepts and components is assessed in a start-to-end simulation, confirming the feasibility of the

  7. Tailoring barrier properties of thermoplastic corn starch-based films (TPCS) by means of a multilayer design.

    Science.gov (United States)

    Fabra, María José; López-Rubio, Amparo; Cabedo, Luis; Lagaron, Jose M

    2016-12-01

    This work compares the effect of adding different biopolyester electrospun coatings made of polycaprolactone (PCL), polylactic acid (PLA) and polyhydroxybutyrate (PHB) on oxygen and water vapour barrier properties of a thermoplastic corn starch (TPCS) film. The morphology of the developed multilayer structures was also examined by Scanning Electron Microscopy (SEM). Results showed a positive linear relationship between the amount of the electrospun coatings deposited onto both sides of the TPCS film and the thickness of the coating. Interestingly, the addition of electrospun biopolyester coatings led to an exponential oxygen and water vapour permeability drop as the amount of the electrospun coating increased. This study demonstrated the versatility of the technology here proposed to tailor the barrier properties of food packaging materials according to the final intended use. PMID:27552416

  8. Design and preliminary test of a free-air ionization chamber for low-energy X-ray

    Institute of Scientific and Technical Information of China (English)

    吴金杰; 杨元第; 王培玮; 陈靖; 柳加成

    2011-01-01

    A free-air ionization chamber in low-energy X-ray has been designed and manufactured at the National Institute of Metrology (NIM, China) according to the defination of air-kerma. The results of a preliminary test show that the leakage current of ionizatio

  9. 高校图书馆残障读者无障碍服务策略研究%Research on Strategies of University Library for the Barrier-free Services for Disabled Readers

    Institute of Scientific and Technical Information of China (English)

    刘源

    2015-01-01

    ABSTRACT:Starting from the contrary relationship between service demands of disabled readers and service status of colleges and universities of China, and connecting with the actual conditions and working features of the libraries of colleges and universities in China, this paper puts forward some strategies for providing the practical barrier-free services for disabled readers and some suggestions on providing the barrier-free services and related resources for social disabled readers.%从我国高校残障读者服务需求和服务现状的矛盾关系出发,结合我国高校图书馆的实际条件、工作特点,提出了针对残障读者的实用性无障碍服务策略,以及高校图书馆无障碍服务与相关资源面向社会残障读者开放的建议。

  10. Cost-effective backhaul design using hybrid radio/free-space optical technology

    KAUST Repository

    Douik, Ahmed S.

    2015-06-08

    The deluge of date rate in today\\'s networks poses a cost burden on the backhaul network design. Developing cost efficient backhaul solutions becomes an interesting, yet challenging, problem. Traditional technologies for backhaul networks include either radio-frequency backhauls (RF) or optical fibres (OF). While RF is a cost-effective solution as compared to OF, it supports lower data rate requirements. Another promising backhaul solution that may combine both a high data rate and a relatively low cost is the free-space optics (FSO). FSO, however, is sensitive to nature conditions (e.g., rain, fog, line-ofsight, etc.). A more reliable alternative is, therefore, to combine RF and FSO solutions through a hybrid structure called hybrid RF/FSO. Consider a backhaul network, where the base-stations (BS) can be connected to each other either via OF or hybrid RF/FSO backhaul links. The paper addresses the problem of minimizing the cost of backhaul planning under connectivity and data rates constraints, so as to choose the appropriate costeffective backhaul type between BSs (i.e., either OF or hybrid RF/FSO). The paper solves the problem using graph theory techniques by introducing the corresponding planning graph. It shows that under a specified realistic assumption about the cost of OF and hybrid RF/FSO links, the problem is equivalent to a maximum weight clique problem, which can be solved with moderate complexity. Simulation results show that our proposed solution shows a close-to-optimal performance, especially for practical prices of the hybrid RF/FSO.

  11. FIELD TEST INSTRUCTION 100-NR-2 OPERABLE UNIT DESIGN OPTIMIZATION STUDY FOR SEQUESTRATION OF SR-90 SATURATED ZONE APATITE PERMEABLE REACTIVE BARRIER EXTENSION

    Energy Technology Data Exchange (ETDEWEB)

    BOWLES NA

    2010-10-06

    The objective of this field test instruction is to provide technical guidance for aqueous injection emplacement of an extension apatite permeable reactive barrier (PRE) for the sequestration of strontium-90 (Sr-90) using a high concentration amendment formulation. These field activities will be conducted according to the guidelines established in DOE/RL-2010-29, 100-NR-2 Design Optimization Study, hereafter referred to as the DOS. The DOS supports the Federal Facility Agreement Consent Order (EPA et al., 1989), Milestone M-16-06-01, and 'Complete Construction of a Permeable Reactive Barrier at 100-N.' Injections of apatite precursor chemicals will occur at an equal distance intervals on each end of the existing PRE to extend the PRB from the existing 91 m (300 ft) to at least 274 m (900 ft). Field testing at the 100-N Area Apatite Treatability Test Site, as depicted on Figure 1, shows that the barrier is categorized by two general hydrologic conceptual models based on overall well capacity and contrast between the Hanford and Ringold hydraulic conductivities. The upstream portion of the original barrier, shown on Figure 1, is characterized by relatively low overall well specific capacity. This is estimated from well development data and a lower contrast in hydraulic conductivity between the Hanford formation and Ringold Formations. Comparison of test results from these two locations indicate that permeability contrast between the Hanford formation and Ringold Formation is significantly less over the upstream one-third of the barrier. The estimated hydraulic conductivity for the Hanford formation and Ringold Formation over the upstream portion of the barrier based on observations during emplacement of the existing 91 m (300 ft) PRB is approximately 12 and 10 m/day (39 and 32 ft/day), respectively (PNNL-17429). However, these estimates should be used as a rough guideline only, as significant variability in hydraulic conductivity is likely to be observed in

  12. HELIOS: the new design of the irradiation of U-free fuels for americium transmutation

    Energy Technology Data Exchange (ETDEWEB)

    D' Agata, E. [European Commission, Joint Research Centre, Institute for Energy, P.O. Box 2, 1755 ZG Petten (Netherlands); Klaassen, F.; Sciolla, C. [Nuclear Research and Consultancy Group, Dept. Life Cycle and Innovations, P.O. Box 25 1755 ZG Petten (Netherlands); Fernandez-Carretero, A. [European Commission, Joint Research Centre, Institute for Transuranium Elements, P.O. Box 2340, 76125 Karlsruhe (Germany); Bonnerot, J.M. [Commissariat a l' Energie Atomique, DEC/SESC/LC2I CEA-Cadarache, 13108 St. Paul lez Durance Cedex (France)

    2009-06-15

    Americium is one of the radioactive elements that mostly contribute to the radiotoxicity of the nuclear spent fuel. Transmutation of long-lived nuclides like Americium is an option for the reduction of the mass, the radiotoxicity and the decay heat of nuclear waste. The HELIOS irradiation experiment is the last evolution in a series of experiments on americium transmutation. The previous experiments, EFTTRA-T4 and T4bis, have shown that the release or trapping of helium is the key issue for the design of such kind of target. In fact, the production of helium, which is characteristic of {sup 241}Am transmutation, is quite significant. The experiment is carried out in the framework of the 4-year project EUROTRANS of the EURATOM 6. Framework Programme (FP6). Therefore, the main objective of the HELIOS experiment is to study the in-pile behaviour of U-free fuels such as CerCer (Pu, Am, Zr)O{sub 2} and Am{sub 2}Zr{sub 2}O{sub 7}+MgO or CerMet (Pu, Am)O{sub 2}+Mo in order to gain knowledge on the role of the fuel microstructure and of the temperature on the gas release and on the fuel swelling. The experiment was planned to be conducted in the HFR (High Flux Reactor) in Petten (The Netherlands) starting the first quarter of 2007. Because of the innovative aspects of the fuel, the fabrication has had some delays as well as the final safety analyses of the original design showed some unexpected deviation. Besides, the HFR reactor has been unavailable since August 2008. Due to the reasons described above, the experiment has been postponed. HELIOS should start in the first quarter of 2009 and will last 300 full power days. The paper will cover the description of the new design of the irradiation experiment HELIOS. The experiment has been split in two parts (HELIOS1 and HELIOS2) which will be irradiated together. Moreover, due to the high temperature achieved in cladding and to the high amount of helium produced during transmutation the experiment previously designed for a

  13. Design and preliminary test of a free-air ionization chamber for low-energy X-ray

    Institute of Scientific and Technical Information of China (English)

    WU Jin-Jie; YANG Yuan-Di; WANG Pei-Wei; CHEN Jing; LIU Jia-Cheng

    2011-01-01

    A free-air ionization chamber in low-energy X-ray has been designed and manufactured at theNational Institute of Metrology (NIM, China) according to the defination of alr-kerma. The results of a preliminary test show that the leakage current of ionization chamber is around 2×10A, and the correction factor of ion recombination for the ionization chamber is also obtained. The free-air ionization chamber is suitable for the primary standard in low-energy X-rays.

  14. Design and analysis of a reconfigurable discrete pin tooling system for molding of three-dimensional free-form objects

    OpenAIRE

    KOÇ, Bahattin; Koc, Bahattin; Thangaswamy, Sridhar

    2010-01-01

    This paper presents the design and analysis of a new reconfigurable tooling for the fabrication of three-dimensional (3D) free-form objects. The proposed reconfigurable tooling system comprises a set of matrices of a closely stacked discrete elements (i.e., pins) arranged to form a cavity in which a free-form object can be molded. By reconfiguring the pins, a single tool can be used in the place of multiple tools to produce different parts with the involvement of much lesser time and cost. Th...

  15. Numerical Analysis of Free Surface in Water Model for Design of Submerged Entry Nozzle

    Directory of Open Access Journals (Sweden)

    Rajat Kumar Das, Sukanta Kumar Dash

    2013-03-01

    Full Text Available Two-dimensionalnumerical simulations usingfinite volume method and an interface capturingschemeare usedto predict the shape of free surfacewave that is created in a mold due to the flow fromsubmergedentry nozzle. In the present work,instead of steel and argon, water and air enter intothe mold. It has been observed that the free surfaceis wavy in nature. Three differentsubmerged entrynozzle(SENmodels were taken for numericalanalysis.Contribution of water velocity,differentport to Bore ratio (P/B, size of upper recirculationroll on free surface were investigated for designinga submerged entry nozzle. Itwas observed that Pent-Roof type nozzleis a betteroneas it shows lesserfluctuation.

  16. A Novel Drag-Free Design for a Geostationary Gravitational Wave Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Given the large volume and additional mass available for scientific use on planned commercial geostationary platforms, we have conceived an alternative drag-free...

  17. Robust Design of a Particle-Free Silver-Organo-Complex Ink with High Conductivity and Inkjet Stability for Flexible Electronics.

    Science.gov (United States)

    Vaseem, Mohammad; McKerricher, Garret; Shamim, Atif

    2016-01-13

    Currently, silver-nanoparticle-based inkjet ink is commercially available. This type of ink has several serious problems such as a complex synthesis protocol, high cost, high sintering temperatures (∼200 °C), particle aggregation, nozzle clogging, poor shelf life, and jetting instability. For the emerging field of printed electronics, these shortcomings in conductive inks are barriers for their widespread use in practical applications. Formulating particle-free silver inks has potential to solve these issues and requires careful design of the silver complexation. The ink complex must meet various requirements, such as in situ reduction, optimum viscosity, storage and jetting stability, smooth uniform sintered films, excellent adhesion, and high conductivity. This study presents a robust formulation of silver-organo-complex (SOC) ink, where complexing molecules act as reducing agents. The 17 wt % silver loaded ink was printed and sintered on a wide range of substrates with uniform surface morphology and excellent adhesion. The jetting stability was monitored for 5 months to confirm that the ink was robust and highly stable with consistent jetting performance. Radio frequency inductors, which are highly sensitive to metal quality, were demonstrated as a proof of concept on flexible PEN substrate. This is a major step toward producing high-quality electronic components with a robust inkjet printing process. PMID:26713357

  18. Robust Design of a Particle-Free Silver-Organo-Complex Ink with High Conductivity and Inkjet Stability for Flexible Electronics

    KAUST Repository

    Vaseem, Mohammad

    2015-12-29

    Currently, silver-nanoparticle-based inkjet ink is commercially available. This type of ink has several serious problems such as a complex synthesis protocol, high cost, high sintering temperatures (∼200 °C), particle aggregation, nozzle clogging, poor shelf life, and jetting instability. For the emerging field of printed electronics, these shortcomings in conductive inks are barriers for their widespread use in practical applications. Formulating particle-free silver inks has potential to solve these issues and requires careful design of the silver complexation. The ink complex must meet various requirements, such as in situ reduction, optimum viscosity, storage and jetting stability, smooth uniform sintered films, excellent adhesion, and high conductivity. This study presents a robust formulation of silver–organo-complex (SOC) ink, where complexing molecules act as reducing agents. The 17 wt % silver loaded ink was printed and sintered on a wide range of substrates with uniform surface morphology and excellent adhesion. The jetting stability was monitored for 5 months to confirm that the ink was robust and highly stable with consistent jetting performance. Radio frequency inductors, which are highly sensitive to metal quality, were demonstrated as a proof of concept on flexible PEN substrate. This is a major step toward producing high-quality electronic components with a robust inkjet printing process.

  19. “There is no free here, you have to pay”: actual and perceived costs as barriers to intermittent preventive treatment of malaria in pregnancy in Mali

    OpenAIRE

    Klein, Meredith C.; Harvey, Steven A.; Diarra, Hawa; Hurley, Emily A.; Rao, Namratha; Diop, Samba; Doumbia, Seydou

    2016-01-01

    Background “There is no free here,” the words of a Malian husband, illustrate how perceptions of cost can deter uptake of intermittent preventive treatment of malaria in pregnancy (IPTp). The Malian Ministry of Health (MOH) recommends a minimum of three doses of IPTp at monthly intervals. However, despite a national policy that IPTp be provided free of charge, only 35 % of pregnant women receive at least one dose and less than 20 % receive two or more doses. Methods This study explored percep...

  20. Managed Aquifer Recharge (MAR) and Design and Construction of Hydraulic Barriers against Seawater Intrusion: the California Case

    Energy Technology Data Exchange (ETDEWEB)

    Foreman, T. L.

    2014-10-01

    Managed aquifer recharge (MAR) has been practiced in California for over a century, using a range of artificial recharge methods, including surface spreading basins, injection wells and aquifer storage and recovery (ASR) wells. Intense municipal and industrial development of coastal regions, particularly in southern California, during and following World War II, led to overdraft of coastal groundwater basins, where groundwater levels were drawn down below sea level, resulting in seawater intrusion into freshwater aquifers. Surface water is imported from the Colorado River and later northern California to satisfy water demands of a growing population. This imported water is also a water supply used for injection into to injection wells constructed in the 1960s along the coastline to repel seawater from intruding into coastal aquifers. Since the 1960s, these seawater intrusion barriers have evolved in terms of water supplied for injection and in their construction and operation details. Imported water supplies are being completely replaced with highly treated wastewater and the injection wells are being constructed so that they are more automated to reduce operational costs. The West Coast Basin of southern California is provided as a case study of the evolution of hydraulic barriers used for protection against seawater intrusion into coastal aquifers. (Author)

  1. Aerodynamic design of a free power turbine for a 75 KW gas turbine automotive engine

    Science.gov (United States)

    Kofskey, M. G.; Katsanis, T.; Schumann, L. F.

    1975-01-01

    A single stage axial-flow turbine having a tip diameter of 15.41 centimeters was designed. The design specifications are given and the aerodynamic design procedure is described. The design includes the transition duct and the turbine exit diffuser. The aerodynamic information includes typical results of a parametric study, velocity diagrams, blade surface and wall velocities, and blade profile and wall coordinates.

  2. Design of a flowing heavy metal target with a free surface for an accelerator driven neutron source

    International Nuclear Information System (INIS)

    In the paper the design of the flowing heavy metal target with free surface under proton beam irradiation within 0.8-1.6 GeV energy and the 10-320 mA current range is presented and analyzed. Following data submitted below: - the results of numerical modeling of the heat deposition in the Pb-Bi eutectic flow due to the penetrating through the proton beam; - the numerical investigation of swirling flow with a free surface; - the calculation of the temperature distributions occurring in the flowing heavy metal target because of the proton beam energy deposition; - the main construction parameters of the flowing heavy metal targets for the proton beams within 0.8-1.6 GeV energy and the 10-320 mA current range; - the design and numerical investigations of the supersonic wind shutter which is needed to isolate the vacuum part of the proton line. 3 refs., 10 figs

  3. Discussion on Energy-saving Design of Laboratory Animal Barrier Environment%实验动物屏障环境节能设计方案探讨

    Institute of Scientific and Technical Information of China (English)

    于承志; 倪训松; 费根林

    2012-01-01

    This article through research in laboratory animal barrier environment different form design of the corridor, as well as how to use the IVC cages, how to deepen the BA design of auto-control system, explains how to reduce energy consumption, ensure clean environment requirements, better meet experimental requirements.%通过研究实验动物屏障环境中走廊的不同设计形式,以及如何采用IVC笼具、如何深化楼宇自控BA系统的设计,阐述了如何降低能耗,保证环境的洁净,更好的满足实验要求.

  4. Proton transfer from water to ketyl radical anion: Assessment of critical size of hydrated cluster and free energy barrier in solution from first principles simulations

    Science.gov (United States)

    Biswas, Sohag; Dasgupta, Teesta; Mallik, Bhabani S.

    2016-09-01

    We present the reactivity of an organic intermediate by studying the proton transfer process from water to ketyl radical anion using gas phase electronic structure calculations and the metadynamics method based first principles molecular dynamics (FPMD) simulations. Our results indicate that during the micro solvation of anion by water molecules systematically, the presence of minimum three water molecules in the gas phase cluster is sufficient to observe the proton transfer event. The analysis of trajectories obtained from initial FPMD simulation of an aqueous solution of the anion does not show any evident of complete transfer of the proton from water. The cooperativity of water molecules and the relatively weak anion-water interaction in liquid state prohibit the full release of the proton. Using biasing potential through first principles metadynamics simulations, we report the observation of proton transfer reaction from water to ketyl radical anion with a barrier height of 16.0 kJ/mol.

  5. Application of 2k Full Factorial Design in Optimization of Solvent-Free Microwave Extraction of Ginger Essential Oil

    OpenAIRE

    Mumtaj Shah; Garg, S K

    2014-01-01

    The solvent-free microwave extraction of essential oil from ginger was optimized using a 23 full factorial design in terms of oil yield to determine the optimum extraction conditions. Sixteen experiments were carried out with three varying parameters, extraction time, microwave power, and type of sample for two levels of each. A first order regression equation best fits the experimental data. The predicted values calculated by the regression model were in good agreement with the experimental ...

  6. Credit Expansion, the Prisoner´s Dilemma, and Free Banking as Mechanism Design

    OpenAIRE

    van den Hauwe, Ludwig

    2008-01-01

    Despite the distinctive character of the Austrian approach to “microfoundations for macroeconomics”, the literature on free banking contains a number of arguments which make use of game-theoretic concepts and models such as the well-known Prisoner´s Dilemma model. While there can be no general a priori presumption against the possible usefulness of game-theoretic concepts for Austrian theorizing, in the context of the debate on free banking such concepts and models have been used with varying...

  7. Low-Impact Air-to-Ground Free-Space Optical Communication System Design and First Results

    CERN Document Server

    Carrasco-Casado, Alberto; Vergaz, Ricardo; Geday, Morten A; Sanchez-Pena, Jose M; Oton, Jose M

    2015-01-01

    An air-to-ground free-space optical communication system has been designed and partially developed. The design covers both the communications between the airborne and the ground station, and the acquisition, tracking and pointing. A strong effort has been made in order to achieve the minimum payload power, size and weight, for which a MEMS modulating retroreflector has been chosen. In the ground station, a new technique for fine pointing, based on a liquid crystal device, is proposed and will be demonstrated, as well as other improvements with the aim of optimizing the ground station performance.

  8. Design of a Mutual Exclusion and Deadlock Algorithm in PCBSD – FreeBSD

    Directory of Open Access Journals (Sweden)

    Libertad Caicedo Acosta

    2014-12-01

    Full Text Available This paper shows the implementation of mutual exclusion in PCBSD-FreeBSD operating systems on SMPng environments, providing solutions to problems like investment priority, priority propagation, interlock, CPU downtime, deadlocks, between other. Mutex Control concept is introduced as a solution to these problems through the integration of the scheduling algorithm of multiple queues fed back and mutexes.

  9. Design of a Mutual Exclusion and Deadlock Algorithm in PCBSD – FreeBSD

    OpenAIRE

    Libertad Caicedo Acosta; Camilo Andrés Ospina Acosta; Nancy Yaneth Gelvez García; Oswaldo Alberto Romero Villalobos

    2014-01-01

    This paper shows the implementation of mutual exclusion in PCBSD-FreeBSD operating systems on SMPng environments, providing solutions to problems like investment priority, priority propagation, interlock, CPU downtime, deadlocks, between other. Mutex Control concept is introduced as a solution to these problems through the integration of the scheduling algorithm of multiple queues fed back and mutexes.

  10. Electrostatic Clustering and Free Energy Calculations Provide a Foundation for Protein Design and Optimization

    OpenAIRE

    Gorham, Ronald D.; Kieslich, Chris A.; Morikis, Dimitrios

    2010-01-01

    Electrostatic interactions are ubiquitous in proteins and dictate stability and function. In this review, we discuss several methods for the analysis of electrostatics in protein–protein interactions. We discuss alanine-scanning mutagenesis, Poisson–Boltzmann electrostatics, free energy calculations, electrostatic similarity distances, and hierarchical clustering of electrostatic potentials. Our recently developed computational framework, known as Analysis of Electrostatic Similarities Of Pro...

  11. Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences.

    Directory of Open Access Journals (Sweden)

    Alexander M Sevy

    2015-07-01

    Full Text Available Computational protein design has found great success in engineering proteins for thermodynamic stability, binding specificity, or enzymatic activity in a 'single state' design (SSD paradigm. Multi-specificity design (MSD, on the other hand, involves considering the stability of multiple protein states simultaneously. We have developed a novel MSD algorithm, which we refer to as REstrained CONvergence in multi-specificity design (RECON. The algorithm allows each state to adopt its own sequence throughout the design process rather than enforcing a single sequence on all states. Convergence to a single sequence is encouraged through an incrementally increasing convergence restraint for corresponding positions. Compared to MSD algorithms that enforce (constrain an identical sequence on all states the energy landscape is simplified, which accelerates the search drastically. As a result, RECON can readily be used in simulations with a flexible protein backbone. We have benchmarked RECON on two design tasks. First, we designed antibodies derived from a common germline gene against their diverse targets to assess recovery of the germline, polyspecific sequence. Second, we design "promiscuous", polyspecific proteins against all binding partners and measure recovery of the native sequence. We show that RECON is able to efficiently recover native-like, biologically relevant sequences in this diverse set of protein complexes.

  12. Decrease-radix design principle for carrying/borrowing free multi-valued and application in ternary optical computer

    Institute of Scientific and Technical Information of China (English)

    YAN JunYong; JIN Yi; ZUO KaiZhong

    2008-01-01

    In this paper a new theory referred to as the decrease-radix design (DRD) is proposed,which is found in the research of logic units of ternary (tri-valued) optical computer.Based on the theory proposed,the principles and the regulations of the DRD for making operation units of multi-valued operation with carrying/borrowing free are also presented.The research work has come to the following important conclusion:let D be a special state contained in n physical informative states,then one may figure out any multi-valued processors within n(n×n) carrying/borrowing free n-valued units by the composition some of n×n×(n-1) simplest basic operating units according to the regulations of DRD proposed in this paper.The detailed systematic way of our design regulations is highlighted step by step in the paper with an example of design of a tri-valued logic optical operating unit.The real architecture,the procedure,and the experimental results of our sample in tri-valued logic operating unit are given.Finally,a re-constructible model of ternary logical optical processor is introduced.The theory proposed in the paper has laid down a solid foundation for the design of re-constructible carrying/borrowing free operating units in ternary optical computers and can be widely used as the designing reference in a variety of multi-valued logic operating units.

  13. Design of fully enclosed acoustic barrier of Yangze River Bridge in Yingwu continent of Wuhan city%武汉市鹦鹉洲长江大桥全封闭声屏障设计

    Institute of Scientific and Technical Information of China (English)

    李明华

    2016-01-01

    根据声屏障声学原理,从建筑景观设计、结构设计、辅助设计等方面,探讨了武汉市鹦鹉洲长江大桥全封闭声屏障设计方法,并介绍了声屏障施工与维护措施,有效解决了高架道路交通噪声问题。%According to acoustical principle of acoustic barrier,starting from aspects of building landscape design,structural design and aided design,the paper explores design methods of fully enclosed acoustic barrier of Yangze River Bridge in Yingwu continent of Wuhan city,and intro-duces acoustic barrier construction and maintenance measures,which effectively solves elevated road traffic noise problem.

  14. Underground explosion barriers - a review

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, B.; O`Beirne, T. [ACIRL Ltd., Booval, Qld. (Australia)

    1997-12-31

    The paper focuses on explosibility conditions in underground coal mines, the behaviour of explosions from initiating gas ignition to violent dust explosions and the effectiveness and limits of operation of current designs of passive explosion barriers in suppressing the flame front. The paper also discusses performance evaluations made in full scale explosion galleries and the use of alternatives to passive barriers, including the installation of active barriers under some circumstances.

  15. Free Future

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    An unintended consequence of the world economic washout is the sharp drop in trade. More disturbing, though, is the fact that many countries are erecting protectionist barriers at the expense of other countries. How can we prevent this unwelcome tendency from intensifying? How will free trade assist in global economic recovery? Hai Wen, Vice President of Peking University, gave his answers in a speech at the Global Think Tank Summit held on July 3-4 in Beijing.

  16. PGM-free Fe-N-C catalysts for oxygen reduction reaction: Catalyst layer design

    Science.gov (United States)

    Stariha, Sarah; Artyushkova, Kateryna; Workman, Michael J.; Serov, Alexey; Mckinney, Sam; Halevi, Barr; Atanassov, Plamen

    2016-09-01

    This work studies the morphology of platinum group metal-free (PGM-free) iron-nitrogen-carbon (Fe-N-C) catalyst layers for the oxygen reduction reaction (ORR) and compares catalytic performance via polarization curves. Three different nitrogen-rich organic precursors are used to prepare the catalysts. Using scanning electron microscopy (SEM) and focused ion beam (FIB) tomography, the porosity, Euler number (pore connectivity), overall roughness, solid phase size and pore size are calculated for catalyst surfaces and volumes. Catalytic activity is determined using membrane electrode assembly (MEA) testing. It is found that the dominant factor in MEA performance is transport limitations. Through the 2D and 3D metrics it is concluded that pore connectivity has the biggest effect on transport performance.

  17. High power optical cavity design and concept of operations for a shipboard free electron laser weapon

    OpenAIRE

    Fontana, Timothy S.

    2003-01-01

    Approved for Public Release; Distribution Unlimited A megawatt (MW)class Free Electron Laser (FEL) as a point defense weapon system may lead to a revolution in anti-ship missile defense. Deep magazine, low cost per shot, proportional engagement capability, and speed of light energy delivery provide the FEL with unmatched advantages over kinetic energy weapon systems. Before an FEL is made fleet deployable, stability, system parameter optimization, and operational utility all must be taken ...

  18. Design Of Digital Configurable Error Free Frequency Detector Using Strobe Signal.

    Directory of Open Access Journals (Sweden)

    Sayannika Banik,

    2014-04-01

    Full Text Available This paper presents a glitch free module using strobe signal which overcomes the limitation of delay mismatch in a wide range of applications. The proposed strobe signal logic can control the occurrence of glitch at both the rising edge and falling edge of the circuit. The theoretical demonstration of the glitch free operation of the proposed strobe signal module is also derived in the paper. The previously proposed digitally controlled delay lines (DCDL has been compared to this technology. Simulation results show the correctness of the module with no delay mismatch with respect to the previously proposed DCDL. As an example application, the strobe signal logic is used in configurable error free frequency detector (a frequency counter which can control the occurrence of glitch during the sudden modulation of the frequency. The employ of the proposed strobe signal can hold the operation of the gate for a specific time until the other gate completes its operation so that there is no delay mismatch.

  19. Development of materials design tool and its application in Pb-free micro-solders in electronic package

    Institute of Scientific and Technical Information of China (English)

    OHNUMA; Ikuo; KAINUMA; Ryosuke; ISHIDA; Kiyohito; CHANG; Austin; Y.

    2010-01-01

    A materials design tool for developing Pb-free soldering alloys in electronic package was developed based on comprehensive experimental data of phase equilibria and thermodynamic properties data accumulated with the CALPHAD (calculation of phase diagrams) method and contains 10 elements,namely,Ag,Au,Bi,Cu,In,Ni,Sb,Sn,Zn and Pb.It can handle the calculation of phase diagrams in all combinations of these elements and all composition ranges.In addition,based on this tool,the liquidus,solidus,phase fractions and constitutions,equilibrium and non-equilibrium solidification behavior,surface tension and viscosity of liquid,diffusion reactions and microstructural evolution,etc.can be predicted.Typical examples of the calculation and application of this tool are presented.The design tool is expected to be a powerful tool for the development of Pb-free solders,as well as for promoting the understanding of the interfacial phenomena between Cu substrate and Pb-free solders in electronic packaging technology.

  20. An 8-Bit ROM-Free AES Design for Low-Cost Applications

    Directory of Open Access Journals (Sweden)

    Ming-Chih Chen

    2013-01-01

    Full Text Available We have presented a memory-less design of the advanced encryption standard (AES with 8-bit data path for applications of wireless communications. The design uses the minimal 160 clock cycles to process a 128-bit data block. For achieving the requirements of low area cost and high performance, new design methods are used to optimize the MixColumns (MC and Inverse MixColumns (IMC and ShiftRows (SR and Inverse ShiftRows (ISR transformations. Our methods can efficiently reduce the required clock cycles, critical path delays, and area costs of these transformations compared with previous designs. In chip realization, our design with both encryption and decryption abilities has a 29% area increase but achieves 4.85 times improvement in throughput/area compared with the best 8-bit AES design reported before. For encryption only, our AES occupies 3.5 k gates with the critical delay of 12.5 ns and achieves a throughput of 64 Mbps which is the best design compared with previous encryption-only designs.

  1. Challenges in Design of an Orientation free Micro Direct Methanol Fuel Cell (µDMFC)

    DEFF Research Database (Denmark)

    Omidvarnia, Farzaneh; Hansen, Hans Nørgaard; Hales, Jan Harry

    2014-01-01

    the challenges in design and manufacturing of a micro direct methanol fuel cell (μDMFC) as the power generator in hearing aid devices is investigated. Among the different challenges in design for μDMFC, the CO2 bubble management and orientation independency of the cell are addressed by proposing a spring loaded...

  2. Electrochemical label-free and reagentless genosensor based on an ion barrier switch-off system for DNA sequence-specific detection of the avian influenza virus.

    Science.gov (United States)

    Kurzątkowska, Katarzyna; Sirko, Agnieszka; Zagórski-Ostoja, Włodzimierz; Dehaen, Wim; Radecka, Hanna; Radecki, Jerzy

    2015-10-01

    This paper concerns the development of genosensors based on redox-active monolayers incorporating (dipyrromethene)2Cu(II) and (dipyrromethene)2Co(II) complexes formed step by step on a gold electrode surface. They were applied for electrochemical determination of oligonucleotide sequences related to avian influenza virus (AIV) type H5N1. A 20-mer probe (NH2-NC3) was covalently attached to the gold electrode surface via a reaction performed in the presence of ethyl(dimethylaminopropyl)carbodiimide / N-hydroxysuccinimide (EDC/NHS) between the amine group present in the probe and carboxylic groups present on the surface of the redox-active layer. Each modification step has been controlled with Osteryoung square-wave voltammetry. The genosensor incorporating the (dipyrromethene)2Cu(II) complex was able to detect a fully complementary single-stranded DNA target with a detection limit of 1.39 pM. A linear dynamic range was observed from 1 to 10 pM. This genosensor displays good discrimination between three single-stranded DNA targets studied: fully complementary, partially complementary (with only six complementary bases), and totally noncomplementary to the probe. When the (dipyrromethene)2Co(II) complex was applied, a detection limit of 1.28 pM for the fully complementary target was obtained. However, this genosensor was not able to discriminate partially complementary and totally noncomplementary oligonucleotide sequences to the probe. Electrochemical measurements, using both types of genosensors in the presence of different supporting electrolytes, were performed in order to elaborate a new mechanism of analytical signal generation based on an ion barrier "switch-off" system. PMID:26359972

  3. Structural Design Principle of Small-Molecule Organic Semiconductors for Metal-Free, Visible-Light-Promoted Photocatalysis.

    Science.gov (United States)

    Wang, Lei; Huang, Wei; Li, Run; Gehrig, Dominik; Blom, Paul W M; Landfester, Katharina; Zhang, Kai A I

    2016-08-01

    Herein, we report on the structural design principle of small-molecule organic semiconductors as metal-free, pure organic and visible light-active photocatalysts. Two series of electron-donor and acceptor-type organic semiconductor molecules were synthesized to meet crucial requirements, such as 1) absorption range in the visible region, 2) sufficient photoredox potential, and 3) long lifetime of photogenerated excitons. The photocatalytic activity was demonstrated in the intermolecular C-H functionalization of electron-rich heteroaromates with malonate derivatives. A mechanistic study of the light-induced electron transport between the organic photocatalyst, substrate, and the sacrificial agent are described. With their tunable absorption range and defined energy-band structure, the small-molecule organic semiconductors could offer a new class of metal-free and visible light-active photocatalysts for chemical reactions.

  4. Motion-free hybrid design laser beam propagation analyzer using a digital micromirror device and a variable focus liquid lens.

    Science.gov (United States)

    Sheikh, Mumtaz; Riza, Nabeel A

    2010-06-01

    To the best of our knowledge, we propose the first motion-free laser beam propagation analyzer with a hybrid design using a digital micromirror device (DMD) and a liquid electronically controlled variable focus lens (ECVFL). Unlike prior analyzers that require profiling the beam at multiple locations along the light propagation axis, the proposed analyzer profiles the beam at the same plane for multiple values of the ECVFL focal length, thus eliminating beam profiler assembly motion. In addition to measuring standard Gaussian beam parameters, the analyzer can also be used to measure the M(2) beam propagation parameter of a multimode beam. Proof-of-concept beam parameter measurements with the proposed analyzer are successfully conducted for a 633 nm laser beam. Given the all-digital nature of the DMD-based profiling and all-analog motion-free nature of the ECVFL beam focus control, the proposed analyzer versus prior art promises better repeatability, speed, and reliability.

  5. Application of 2k Full Factorial Design in Optimization of Solvent-Free Microwave Extraction of Ginger Essential Oil

    Directory of Open Access Journals (Sweden)

    Mumtaj Shah

    2014-01-01

    Full Text Available The solvent-free microwave extraction of essential oil from ginger was optimized using a 23 full factorial design in terms of oil yield to determine the optimum extraction conditions. Sixteen experiments were carried out with three varying parameters, extraction time, microwave power, and type of sample for two levels of each. A first order regression equation best fits the experimental data. The predicted values calculated by the regression model were in good agreement with the experimental values. The results showed that the extraction time is the most prominent factor followed by microwave power level and sample type for extraction process. An average of 0.25% of ginger oil can be extracted using current setup. The optimum conditions for the ginger oil extraction using SFME were the extraction time 30 minutes, microwave power level 640 watts, and sample type, crushed sample. Solvent-free microwave extraction proves a green and promising technique for essential oil extraction.

  6. Removing Capacitive Touch Screen Design Barriers%如何解决电容式触摸屏设计屏障

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    This article introduces the key barriers to the mobile phone touch screen design, such as charger and display noise, power consumption, control precision, cost and ease of use, and how Cypress’s Gen4 solution takes these challenges.%  本文介绍了手机电容式触摸屏设计过程中常见的难题,如充电器和显示器噪声、功耗、触控精度、成本、易用性以及采用赛普拉斯半导体有限公司的Gen4解决方案能够从容应对这些挑战的原理。

  7. Design of serum-free medium for suspension culture of CHO cells on the basis of general commercial media.

    Science.gov (United States)

    Miki, Hideo; Takagi, Mutsumi

    2015-08-01

    The design of serum-free media for suspension culture of genetically engineered Chinese hamster ovary (CHO) cells using general commercial media as a basis was investigated. Subcultivation using a commercial serum-free medium containing insulin-like growth factor (IGF)-1 with or without FCS necessitated additives other than IGF-1 to compensate for the lack of FCS and improve cell growth. Suspension culture with media containing several combinations of growth factors suggested the effectiveness of addition of both IGF-1 and the lipid signaling molecule lysophosphatidic acid (LPA) for promoting cell growth. Subcultivation of CHO cells in suspension culture using the commercial serum-free medium EX-CELL™302, which contained an IGF-1 analog, supplemented with LPA resulted in gradually increasing specific growth rate comparable to the serum-containing medium and in almost the same high antibody production regardless of the number of generations. The culture with EX-CELL™302 supplemented with LPA in a jar fermentor with pH control at 6.9 showed an apparently higher cell growth rate than the cultures without pH control and with pH control at 6.8. The cell growth in the medium supplemented with aurintricarboxylic acid (ATA), which was much cheaper than IGF-1, in combination with LPA was synergistically promoted similarly to that in the medium supplemented with IGF-1 and LPA. In conclusion, the serum-free medium designed on the basis of general commercial media could support the growth of CHO cells and antibody production comparable to serum-containing medium in suspension culture. Moreover, the possibility of cost reduction by the substitution of IGF-1 with ATA was also shown.

  8. Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood–brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk

    Science.gov (United States)

    2013-01-01

    Background Human immunodeficiency virus-1 (HIV-1) enters the brain by crossing the blood–brain barrier (BBB) as both free virus and within infected immune cells. Previous work showed that activation of the innate immune system with lipopolysaccharide (LPS) enhances free virus transport both in vivo and across monolayer monocultures of brain microvascular endothelial cells (BMECs) in vitro. Methods Here, we used monocultures and co-cultures of brain pericytes and brain endothelial cells to examine the crosstalk between these cell types in mediating the LPS-enhanced permeation of radioactively-labeled HIV-1 (I-HIV) across BMEC monolayers. Results We found that brain pericytes when co-cultured with BMEC monolayers magnified the LPS-enhanced transport of I-HIV without altering transendothelial electrical resistance, indicating that pericytes affected the transcytotic component of HIV-1 permeation. As LPS crosses the BBB poorly if at all, and since pericytes are on the abluminal side of the BBB, we postulated that luminal LPS acts indirectly on pericytes through abluminal secretions from BMECs. Consistent with this, we found that the pattern of secretion of cytokines by pericytes directly exposed to LPS was different than when the pericytes were exposed to the abluminal fluid from LPS-treated BMEC monolayers. Conclusion These results are evidence for a cellular crosstalk in which LPS acts at the luminal surface of the brain endothelial cell, inducing abluminal secretions that stimulate pericytes to release substances that enhance the permeability of the BMEC monolayer to HIV. PMID:23816186

  9. Free-Energy Barriers and Reaction Mechanisms for the Electrochemical Reduction of CO on the Cu(100) Surface, Including Multiple Layers of Explicit Solvent at pH 0.

    Science.gov (United States)

    Cheng, Tao; Xiao, Hai; Goddard, William A

    2015-12-01

    The great interest in the photochemical reduction from CO2 to fuels and chemicals has focused attention on Cu because of its unique ability to catalyze formation of carbon-containing fuels and chemicals. A particular goal is to learn how to modify the Cu catalysts to enhance the production selectivity while reducing the energy requirements (overpotential). To enable such developments, we report here the free-energy reaction barriers and mechanistic pathways on the Cu(100) surface, which produces only CH4 (not C2H4 or CH3OH) in acid (pH 0). We predict a threshold potential for CH4 formation of -0.52 V, which compares well to experiments at low pH, -0.45 to -0.50 V. These quantum molecular dynamics simulations included ∼5 layers of explicit water at the water/electrode interface using enhanced sampling methodology to obtain the free energies. We find that that chemisorbed hydroxyl-methylene (CH-OH) is the key intermediate determining the selectivity for methane over methanol. PMID:26562750

  10. Minimum lens complexity design approach for a free-space macro-optical multichip global interconnection module

    Science.gov (United States)

    Milojkovic, Predrag; Christensen, Marc P.; Haney, Michael W.

    2000-05-01

    The FAST-Net (Free-space Accelerator for Switching Terabit Networks) concept uses an array of wide field-of-view imaging lenses to realize a high-density shuffle interconnect across an array of smart-pixel integrated circuits. This paper presents a design approach for these lenses that achieves the minimum complexity required to meet the demands of the FAST-Net concept's off-axis multi-chip environment. Generalized eikonals for arbitrary surfaces were examined to determine the performance bounds for the FAST-Net optical system. Then an analysis provided an estimate of 6 for the number of spherical surfaces needed to achieve good optical resolution and distortion performance across an array of 10-micron diameter VCSEL sources that are imaged onto a array of 50-micron wide detectors. A ray trace simulation confirmed this number. Subsequent analysis evaluated the achievable efficient of replacing spherical surfaces with aspherical ones. By exploiting the mismatch between the low numerical aperture VCSELs and relatively higher numerical aperture interconnection optics, it was found that 3 aspherical surfaces could replace 6 spherical surfaces in the FAST-Net system for the specified performance criteria. A lens design that utilizes 3 aspherical surfaces and achieves necessary registration and resolution of the FAST-Net system was determined. The results provide a general framework for the design of wide field-of-view free space interconnection systems that incorporate high-density VCSEL arrays.

  11. Visual design and verification tool for collision-free dexterous patient specific neurosurgical instruments

    Science.gov (United States)

    Hess, Maggie; Eastwood, Kyle; Linder, Bence; Bodani, Vivek; Lasso, Andras; Looi, Thomas; Fichtinger, Gabor; Drake, James

    2016-03-01

    PURPOSE: In many minimally invasive neurosurgical procedures, the surgical workspace is a small tortuous cavity that is accessed using straight, rigid instruments with limited dexterity. Specifically considering neuroendoscopy, it is often challenging for surgeons, using standard instruments, to reach multiple surgical targets from a single incision. To address this problem, continuum tools are under development to create highly dexterous minimally invasive instruments. However, this design process is not trivial, and therefore, a user-friendly design platform capable of easily incorporating surgeon input is needed. METHODS: We propose a method that uses simulation and visual verification to design continuum tools that are patient and procedure specific. Our software module utilizes pre-operative scans and virtual threedimensional (3D) patient models to intuitively aid instrument design. The user specifies basic tool parameters and the parameterized tools and trocar are modeled within the virtual patient. By selecting and dragging the instrument models, the tools are instantly reshaped and repositioned. The tool geometry and surgical entry points are then returned as outputs to undergo optimization. We have completed an initial validation of the software by comparing a simulation of a physical instrument's reachability to the corresponding virtual design. RESULTS AND CONCLUSION: The software was assessed qualitatively by two neurosurgeons, who design tools for an intraventricular endoscopic procedure. Further, validation experiments comparing the design of a virtual instrument to a physical tool demonstrate that the software module functions correctly. Thus, our platform permits user-friendly, application specific design of continuum instruments. These instruments will give surgeons much more flexibility in developing future minimally invasive procedures.

  12. Design Low Crosstalk Ring-Slot Array Structure for Label-Free Multiplexed Sensing

    Directory of Open Access Journals (Sweden)

    Lijun Huang

    2014-08-01

    Full Text Available We theoretically demonstrate a low crosstalk ring-slot array structure used for label-free multiplexed sensing. The proposed sensors array is based on an array of three ring-slot and input/output line defect coupling waveguides. Each ring-slot cavity has slightly different cavity spacing and different resonant frequency. Results obtained using two dimensional finite-difference time-domain (2D-FDTD simulation indicate that the resonant frequencies of each sensor unit in response to the refractive index variations are independent. The refractive index sensitivity is 134 ~ 145.5 nm/RIU (refractive index unit and the Q factors more than 104 can be achieved. The calculated detect limit lower than 1.13 × 10−4 RIU is obtained. In addition, an extremely small crosstalk lower than −25.8 dB is achieved among the array of three ring-slot cavities. The results demonstrate that this multiplexed sensor array is a promising platform for integrated optical devices and enables highly parallel label-free detection.

  13. Design and Application of Offset-Free Model Predictive Control Disturbance Observation Method

    Directory of Open Access Journals (Sweden)

    Xue Wang

    2016-01-01

    Full Text Available Model predictive control (MPC with its lower request to the mathematical model, excellent control performance, and convenience online calculation has developed into a very important subdiscipline with rich theory foundation and practical application. However, unmeasurable disturbance is widespread in industrial processes, which is difficult to deal with directly at present. In most of the implemented MPC strategies, the method of incorporating a constant output disturbance into the process model is introduced to solve this problem, but it fails to achieve offset-free control once the unmeasured disturbances access the process. Based on the Kalman filter theory, the problem is solved by using a more general disturbance model which is superior to the constant output disturbance model. This paper presents the necessary conditions for offset-free model predictive control based on the model. By applying disturbance model, the unmeasurable disturbance vectors are augmented as the states of control system, and the Kalman filer is used to estimate unmeasurable disturbance and its effect on the output. Then, the dynamic matrix control (DMC algorithm is improved by utilizing the feed-forward compensation control strategy with the disturbance estimated.

  14. Design, manufacturing and tests of first cryogen-free MgB2 prototype coils for offshore wind generators

    Science.gov (United States)

    Sarmiento, G.; Sanz, S.; Pujana, A.; Merino, J. M.; Iturbe, R.; Apiñaniz, S.; Nardelli, D.; Marino, I.

    2014-05-01

    Although renewable sector has started to take advantage of the offshore wind energy recently, the development is very intense. Turbines reliability, size, and cost are key aspects for the wind industry, especially in marine locations. A superconducting generator will allow a significant reduction in terms of weight and size, but cost and reliability are two aspects to deal with. MgB2 wire is presented as one promising option to be used in superconducting coils for wind generators. This work shows the experimental results in first cryogen-free MgB2 prototype coils, designed according to specific requirements of TECNALIA's wind generator concept.

  15. Design of FELiChEM, the first infrared free-electron laser user facility in China

    CERN Document Server

    Li, He-Ting; Zhang, Shan-Cai; Wang, Lin; Yang, Yong-Liang

    2016-01-01

    FELiChEM is a new experimental facility under construction at University of Science and Technology of China (USTC), whose core device is two free electron laser oscillators generating middle-infrared and far-infrared laser and covering the spectral range of 2.5-200 ?m. It will be a dedicated infrared light source aiming at energy chemistry research. We present the brief design of FEL oscillators with the emphasis put on the middle-infrared oscillator. Most of the basic parameters are determined and the anticipated performance of the output radiation is given. The first light of FELiChEM is targeted for the end of 2017.

  16. City urban design in a free market economy: The case of Ljubljana, Slovenia

    Directory of Open Access Journals (Sweden)

    Dimitrovska-Andrews Kaliopa

    2002-01-01

    Full Text Available A recent rapid political and economic changes in many eastern European countries demand corresponding changes in the town planning system, and especially in the development control and urban management process. For instance, at a present many historic city and town cores still remain relatively intact in their original form, but have become the target for development pressure. How should this pressure be channeled to achieve enhancement of the urban qualities of those areas (especially barracks and old factory sites, without jeopardising their competitiveness for attracting business and employment. This paper discusses the outcomes of research carried out at the Urban Planning Institute of the Republic of Slovenia from 1995 to 1998, on the development of appropriate methods for the appraisal and promotion of design quality in relation to economic viability in city development projects especially for an urban renewal. The elements for the assessment of urban design quality derive from the basic principles of good urban design such as identity, permeability, legibility visual appropriateness, robustness, visual and symbolic richness, amongst others. The simplified computerised model for assessing financial viability is based on building costs and market value of the investment, and shows the profitability of the development. It can be a useful tool in both assessing design viability, and for determining extra profit or ‘planning gain’ in the planning process negotiations such ‘surplus’ can be used for satisfying local needs (e.g. additional programs, design of public spaces. This method for appraisal and promotion of design quality in relation to economic viability has been examined through an assessment of the competition projects for the renewal of the Rog factory area in the city centre of Ljubljana. This case study has revealed the need for a clear strategy for future city development, with marketing guidance and policies for positive

  17. Inversion-free decentralised quantitative feedback design of large-scale systems

    Science.gov (United States)

    Labibi, B.; Mahdi Alavi, S. M.

    2016-06-01

    In this paper, a new method for robust decentralised control of multi-input multi-output (MIMO) systems using quantitative feedback theory (QFT) is suggested. The proposed method does not need inversion of the plant transfer function matrix in the design process. For a given system, an equivalent descriptor system representation is defined. By using this representation, sufficient conditions for closed-loop diagonal dominance over the uncertainty space are obtained. These conditions transform the original MIMO system into a set of isolated multi-input single-output (MISO) subsystems. Then, the local controllers are designed by using the typical MISO QFT technique for each isolated subsystem to satisfy the predefined desired specifications and the closed-loop diagonal dominance sufficient conditions. The proposed technique is less conservative in comparison to the approaches using the over-bounding concept in the design procedure. The effectiveness of the proposed technique is finally assessed on a MIMO Scara robot.

  18. Design of a Label-Free, Distributed Bragg Grating Resonator Based Dielectric Waveguide Biosensor

    Directory of Open Access Journals (Sweden)

    Florian Kehl

    2015-01-01

    Full Text Available In this work, we present a resonant, dielectric waveguide device based on distributed Bragg gratings for label-free biosensing applications. The refractive index sensitive optical transducer aims at improving the performance of planar waveguide grating sensor systems with limited Q-factor and dynamic range by combing the advantages of resonant cavities, such as a multitude of resonance peaks with high finesse, with the manageable complexity of waveguide grating couplers. The general sensor concept is introduced and supported by theoretical considerations as well as numerical simulations based on Coupled Mode Theory. In contrast to a single Bragg grating reflector, the presented Fabry-Pérot type distributed Bragg resonator exhibits an extended measurement range as well as relaxed fabrication tolerances. The resulting, relatively simple sensor structure can be fabricated with standard lithographic means and is independent of expensive light-sources and/or detectors, making an affordable but sensitive device, potentially suitable for point-of-care applications.

  19. Molecular design of electron transport with orbital rule: toward conductance-decay free molecular junctions.

    Science.gov (United States)

    Tada, Tomofumi; Yoshizawa, Kazunari

    2015-12-28

    In this study, we report our viewpoint of single molecular conductance in terms of frontier orbitals. The orbital rule derived from orbital phase and amplitude is a powerful guideline for the qualitative understanding of molecular conductance in both theoretical and experimental studies. The essence of the orbital rule is the phase-related quantum interference, and on the basis of this rule a constructive or destructive pathway for electron transport is easily predicted. We have worked on the construction of the orbital rule for more than ten years and recently found from its application that π-stacked molecular junctions fabricated experimentally are in line with the concept for conductance-decay free junctions. We explain the orbital rule using benzene molecular junctions with the para-, meta- and ortho-connections and discuss linear π-conjugated chains and π-stacked molecular junctions with respect to their small decay factors in this manuscript.

  20. Mixture design of rice flour, maize starch and wheat starch for optimization of gluten free bread quality.

    Science.gov (United States)

    Mancebo, Camino M; Merino, Cristina; Martínez, Mario M; Gómez, Manuel

    2015-10-01

    Gluten-free bread production requires gluten-free flours or starches. Rice flour and maize starch are two of the most commonly used raw materials. Over recent years, gluten-free wheat starch is available on the market. The aim of this research was to optimize mixtures of rice flour, maize starch and wheat starch using an experimental mixture design. For this purpose, dough rheology and its fermentation behaviour were studied. Quality bread parameters such as specific volume, texture, cell structure, colour and acceptability were also analysed. Generally, starch incorporation reduced G* and increased the bread specific volume and cell density, but the breads obtained were paler than the rice flour breads. Comparing the starches, wheat starch breads had better overall acceptability and had a greater volume than maize-starch bread. The highest value for sensorial acceptability corresponded to the bread produced with a mixture of rice flour (59 g/100 g) and wheat starch (41 g/100 g). PMID:26396377

  1. Neurological disorders and barriers for neurological rehabilitation in rural areas in Uttar Pradesh: A cross-sectional study

    OpenAIRE

    Hirdesh Kumar; Nalina Gupta

    2012-01-01

    Background: In India, the majority of individuals with neurological disorders are rural based and cannot even afford the cost of rehabilitation. At the same time, we do not have barrier free environment in India. Aim: This study attempts to find out the neurological disorders and barriers for neurological rehabilitation in rural areas in Uttar Pradesh, India. Setting: Rural areas in Uttar Pradesh, India. Design: It is a cross-sectional study. Materials and Methods: The study was done by means...

  2. Large Wind Turbine Rotor Design using an Aero-Elastic / Free-Wake Panel Coupling Code

    DEFF Research Database (Denmark)

    Sessarego, Matias; Ramos García, Néstor; Shen, Wen Zhong;

    2016-01-01

    Despite the advances in computing resources in the recent years, the majority of large wind-turbine rotor design problems still rely on aero-elastic codes that use blade element momentum (BEM) approaches to model the rotor aerodynamics. The present work describes an approach to wind-turbine rotor...

  3. Deriving Function-failure Similarity Information for Failure-free Rotorcraft Component Design

    Science.gov (United States)

    Roberts, Rory A.; Stone, Robert B.; Tumer, Irem Y.; Clancy, Daniel (Technical Monitor)

    2002-01-01

    Performance and safety are the top concerns of high-risk aerospace applications at NASA. Eliminating or reducing performance and safety problems can be achieved with a thorough understanding of potential failure modes in the design that lead to these problems. The majority of techniques use prior knowledge and experience as well as Failure Modes and Effects as methods to determine potential failure modes of aircraft. The aircraft design needs to be passed through a general technique to ensure that every potential failure mode is considered, while avoiding spending time on improbable failure modes. In this work, this is accomplished by mapping failure modes to certain components, which are described by their functionality. In turn, the failure modes are then linked to the basic functions that are carried within the components of the aircraft. Using the technique proposed in this paper, designers can examine the basic functions, and select appropriate analyses to eliminate or design out the potential failure modes. This method was previously applied to a simple rotating machine test rig with basic functions that are common to a rotorcraft. In this paper, this technique is applied to the engine and power train of a rotorcraft, using failures and functions obtained from accident reports and engineering drawings.

  4. Using Free Computational Resources to Illustrate the Drug Design Process in an Undergraduate Medicinal Chemistry Course

    Science.gov (United States)

    Rodrigues, Ricardo P.; Andrade, Saulo F.; Mantoani, Susimaire P.; Eifler-Lima, Vera L.; Silva, Vinicius B.; Kawano, Daniel F.

    2015-01-01

    Advances in, and dissemination of, computer technologies in the field of drug research now enable the use of molecular modeling tools to teach important concepts of drug design to chemistry and pharmacy students. A series of computer laboratories is described to introduce undergraduate students to commonly adopted "in silico" drug design…

  5. A composite nanostructured electron-transport layer for stable hole-conductor free perovskite solar cells: design and characterization

    Science.gov (United States)

    Yu, Zhenhua; Qi, Fei; Liu, Pei; You, Sujian; Kondamareddy, Kiran Kumar; Wang, Changlei; Cheng, Nian; Bai, Sihang; Liu, Wei; Guo, Shishang; Zhao, Xing-Zhong

    2016-03-01

    A novel composite nanostructured titanium dioxide (TiO2) based electron-transport layer (ETL) is designed by combining size blended nanoparticles (SBNP) and nanoarrays (NA) for efficient perovskite solar cell (PSC) applications. The composite nanostructured (SBNP + NA) ETL is successfully employed in hole-conductor free PSCs, there by achieving a stable device with a maximum efficiency of 13.5%. The improvement in the performance is attributed to the better charge transport and lower recombination in the SBNP + NA ETL. Despite the stable high efficiency, SBNP + NA ETL based PSCs are advantageous owing to their low cost, ease of all-solution fabrication process in an open environment and good reproducibility.A novel composite nanostructured titanium dioxide (TiO2) based electron-transport layer (ETL) is designed by combining size blended nanoparticles (SBNP) and nanoarrays (NA) for efficient perovskite solar cell (PSC) applications. The composite nanostructured (SBNP + NA) ETL is successfully employed in hole-conductor free PSCs, there by achieving a stable device with a maximum efficiency of 13.5%. The improvement in the performance is attributed to the better charge transport and lower recombination in the SBNP + NA ETL. Despite the stable high efficiency, SBNP + NA ETL based PSCs are advantageous owing to their low cost, ease of all-solution fabrication process in an open environment and good reproducibility. Electronic supplementary information (ESI) available: Details of the experimental section and ESI figures. See DOI: 10.1039/c5nr09045h

  6. Governance Structures of Free/Open Source Software Development: Examining the role of modular product design as a governance mechanism in the FreeBSD Project

    NARCIS (Netherlands)

    Dafermos, G.

    2012-01-01

    My dissertation looks at the Governance Structures of Free/Open Source (FOSS) Development, based on a case study of FreeBSD, a large FOSS project. More specifically, it examines 3 well-known theories. The 1st theory [decreasing returns to scale] holds that increasing the number of persons working to

  7. Structural optimization of free form framed structures in early stages of design

    OpenAIRE

    Veltkamp, Martijn

    2010-01-01

    p. 1078-1089 The present paper proposes the application of topology optimisation software to generate topologically optimised building components in prestressed concrete, and the realisation of optimised shapes via large scale CNC-milling technology. Topology optimisation within architectural design holds a potential for simultaneously reducing material usage and evolving new structural morphologies that challenge the aesthetics of architectural appearance as well as the relate...

  8. A Complete Design of a Rare Earth Metal-Free Permanent Magnet Generator

    Directory of Open Access Journals (Sweden)

    Petter Eklund

    2014-05-01

    Full Text Available The price of rare-earth metals used in neodymium-iron-boron (NdFeB permanent magnets (PMs has fluctuated greatly recently. Replacing the NdFeB PMs with more abundant ferrite PMs will avoid the cost insecurity and insecurity of supply. Ferrite PMs have lower performance than NdFeB PMs and for similar performance more PM material has to be used, requiring more support structure. Flux concentration is also necessary, for example, by a spoke-type rotor. In this paper the rotor of a 12 kW NdFeB PM generator was redesigned to use ferrite PMs, reusing the existing stator and experimental setup. Finite element simulations were used to calculate both electromagnetic and mechanical properties of the design. Focus was on mechanical design and feasibility of construction. The result was a design of a ferrite PM rotor to be used with the old stator with some small changes to the generator support structure. The new generator has the same output power at a slightly lower voltage level. It was concluded that it is possible to use the same stator with either a NdFeB PM rotor or a ferrite PM rotor. A ferrite PM generator might require a larger diameter than a NdFeB generator to generate the same voltage.

  9. Simplified approach for design of raft foundations against fault rupture. Part Ⅰ: free-field

    Institute of Scientific and Technical Information of China (English)

    I. Anastasopoulos; N. Gerolymos; G. Gazetas; M. F. Bransby

    2008-01-01

    Over the past few decades, earthquake engineering research mainly focused on the effects of strong seismicshaking. After the 1999 earthquakes in Turkey and Taiwan, and thanks to numerous cases where fault rupture causedsubstantial damage to structures, the importance of faulting-induced deformation has re-emerged. This paper, along withits companion (Part Ⅱ), exploits parametric results of finite element analyses and centrifuge model testing in developing afour-step semi-analytical approach for analysis of dip-slip (normal and thrust) fault rupture propagation through sand, itsemergence on the ground surface, and its interaction with raft foundations. The present paper (Part Ⅰ) focuses on the effectsof faulting in the absence of a structure (i.e., in the free-field). The semi-analytical approach comprises two-steps: the firstdeals with the rupture path and the estimation of the location of fault outcropping, and the second with the tectonically-induced displacement profile at the ground surface. In both cases, simple mechanical analogues are used to derive simplifiedsemi-analytical expressions. Centrifuge model test data, in combination with parametric results from nonlinear finite elementanalyses, are utilized for model calibration. The derived semi-analytical expressions are shown to compare reasonably wellwith more rigorous experimental and theoretical data, thus providing a useful tool for a first estimation of near-fault seismichazard.

  10. Improved efficiency droop characteristics in an InGaN/GaN light-emitting diode with a novel designed last barrier structure

    Institute of Scientific and Technical Information of China (English)

    Wang Tian-Hu; Xu Jin-Liang

    2012-01-01

    In this study,the characteristics of nitride-based light-emitting diodes with different last barrier structures are analysed numerically.The energy band diagrams,electrostatic field near the last quantum barrier,carrier concentration in the quantum well,internal quantum efficiency,and light output power are systematically investigated.The simulation results show that the efficiency droop is inarkedly improved and the output power is greatly enhanced when the conventional GaN last barrier is replaced by an AIGaN barrier with Al composition graded linearly from 0 to 15% in the growth direction.These improvements are attributed to enhanced efficiencies of electron confinement and hole injection caused by the lower polarization effect at the last-barrier/electron blocking layer interface when the graded Al composition last barrier is used.

  11. Barriers to SCM implementing

    Directory of Open Access Journals (Sweden)

    M.E. Rosli

    2008-12-01

    Full Text Available Purpose: This paper explores the barriers faced by Malaysian manufacturing companies in successfullyimplementing the Supply Chain Management (SCM. The study has highlighted some pertinent factorsperforming the barriers that are most frequently reported by the studied companies. Sixteen companies, fromservice and manufacturing companies were studied over a period of two years to assess their SCM practicesthrough survey and interview processes.Design/methodology/approach: This part discusses the research design and methodological issues upon whichthe research is based. The explanation includes two types of research methods, short survey and follow-upinterviews that were identified as being suitable to achieve the aims of this study, which is to identify the currentproblem of SCM practices within the Malaysian SMEs. Research design is a framework or plan for researchused as a guide in collecting and analysing data.Findings: The results showed that the barriers are depending on the types or group of companies business; suchas either it is an SME or a big company. The barriers inhibiting the practice of SCM can be summarized inthe following factors: partnership with suppliers, limited expertise, management commitment, understanding ofSCM, supported technologies and customer satisfaction. The findings are also compared with the results of asimilar study on SCM in other country.Practical implications: Some suggestions are also offered, which is believed to be a good strategy to the companiesto manage the SCM that will lead to sustainable competitive advantage and hence improve their market share.Originality/value: There are interesting barriers between the companies in Malaysia and other country in therespect of SCM implementation. These findings can be used by both Malaysian and other companies to worktogether or review the SCM strategies that will lead to sustainable competitive advantage and hence improvetheir business performance.

  12. Design and application of coaxial wigglers in free-electron lasers

    Science.gov (United States)

    Jackson, Robert H.; Blank, Monica; Freund, Henry P.; Pershing, Dean E.; Taccetti, J. M.

    1995-09-01

    The Naval Research Laboratory is investigating innovative magnetic wigglers to reduce beam energy requirements for millimeter wave FELs and to enhance the gain and efficiency. Recent work has focused on coaxial designs. The advantages of this are twofold. First, annular configurations are advantageous for propagating high current beams. The annular geometry permits use of the central structure to enhance the wiggler field, hence, allowing shorter wiggler periods. One such wiggler is referred to as the Coaxial Hybrid Iron (CHI) wiggler, and employs a solenoid enclosing periodic arrays of ferromagnetic and nonferromagnetic material arranged as an outer ring and an inner rod. A second wiggler uses both outer and inner bifilar helical current windings. Both wiggler designs result in substantial enhancements in the wiggler field experienced by the electron beam as compared with the fields in the absence of the central structure. A prototype CHI wiggler is discussed along with a 35 GHz amplifier experiment which is under construction. Preliminary performance calculations for a two helix wiggler system are discussed. This will include both orbit theory and a fully 3D nonlinear simulation of the interaction.

  13. Design of the blisk of an aircraft turbojet engine and verification of its resonance free operation

    Directory of Open Access Journals (Sweden)

    Chromek L.

    2016-06-01

    Full Text Available Integral turbine wheels belong to one of the most stressed parts of jet aircraft engines. In addition to high rotational speeds and temperatures, they are also subjected to dynamic forces from a non-uniform pressure field in the flow path. Dynamic forces even at a relatively small amplitude can cause failure by fatigue, which leads to fracture of blades and crash of the machine. These adverse conditions, called resonance, should be avoided already in the design stage when a suitable choice of stator vanes and the number of blades can move the critical speed of the blisk beyond the operating speed or at least reduce their influence. In the case of a small jet engine produced by the První brněnská strojírna (PBS Velká Bíteš, the operating speed is of nearly half of the entire speed range of the machine. This makes the design of a proposed turbine wheel very complicated. A higher harmonic order of aerodynamic excitation is almost always present, its influence was therefore tested experimentally by vibration tests in the test station PBS Velká Bíteš.

  14. Hybrid microtransmitter for free-space optical spacecraft communication: design, manufacturing, and characterization

    Science.gov (United States)

    Lotfi, Sara; Palmer, Kristoffer; Kratz, Henrik; Thornell, Greger

    2009-02-01

    Optical intra-communication links are investigated by several currently operational qualification missions. Compared with RF communication systems, the optical domain obtains a wider bandwidth, enables miniaturized spacecraft and reduced power consumption. In this project, a microtransmitter is designed and manufactured for formation flying spacecraft with transmission rates of 1 Gbit/s. Simulations in Matlab and Simulink show that a BER of 10-9 can be achieved with aperture sizes of 1 cm and a transmitter output peak power of 12 mW for a distance of 10 km. The results show that the performance of the communication link decreases due to mechanical vibrations in the spacecraft together with a narrow laser beam. A dual-axis microactuator designed as a deflectable mirror has been developed for the laser beam steering where the fabrication is based on a double-sided, bulk micromachining process. The mirror actuates by joints consisting of v-grooves filled with SU-8 polymer. The deflection is controlled by integrated resistive heaters in the joints causing the polymer to expand thermally. Results show that the mirror actuates 20-30° in the temperature interval 25-250°C. Flat Fresnel lenses made of Pyrex 7740 are used to collimate the laser beam. These lenses are simulated in the Comsol software and optimized for a 670 nm red VCSEL. The lenses are manufactured using lithography and reactive ion etching. All tests are made in a normal laboratory environment, but the effect of the space environment is discussed.

  15. Design and Implementation of Input/Output Subsystem of FreeBSD%FreeBSD中I/O系统的研究与分析

    Institute of Scientific and Technical Information of China (English)

    潘学俭; 梁洪亮; 吕洪利

    2007-01-01

    FreeBSD操作系统提供了一个性能突出、便于扩展、灵活性高的经典I/O子系统.通过分析FreeBSD内核源代码对I/O子系统进行了深入研究,并以一个读请求的实例清晰地展示了其输入/输出操作的整个流程.

  16. Feasibility of a novel design of high resolution parallax-free Compton enhanced PET scanner dedicated to brain research

    Energy Technology Data Exchange (ETDEWEB)

    Braem, A [CERN, PH Department, CH-1211 Geneva (Switzerland); Llatas, M Chamizo [Department of Corpuscular and Nuclear Physics, Geneva University, Geneva (Switzerland); Chesi, E [CERN, PH Department, CH-1211 Geneva (Switzerland); Correia, J G [Instituto Tecnologico e Nuclear, Sacavem (Portugal); Garibaldi, F [Instituto Superiore di Sanita, Roma (Italy); Joram, C [CERN, PH Department, CH-1211 Geneva (Switzerland); Mathot, S [CERN, PH Department, CH-1211 Geneva (Switzerland); Nappi, E [INFN, Sezione di Bari, Bari (Italy); Silva, M Ribeiro da [Centro de FIsica Nuclear da Universidade de Lisboa, Lisbon (Portugal); Schoenahl, F [Division of Nuclear Medicine, Geneva University Hospital, CH-1211 Geneva (Switzerland); Seguinot, J [CERN, PH Department, CH-1211 Geneva (Switzerland); Weilhammer, P [CERN, PH Department, CH-1211 Geneva (Switzerland); Zaidi, H [Division of Nuclear Medicine, Geneva University Hospital, CH-1211 Geneva (Switzerland)

    2004-06-21

    A novel concept for a positron emission tomography (PET) camera module is proposed, which provides full 3D reconstruction with high resolution over the total detector volume, free of parallax errors. The key components are a matrix of long scintillator crystals and hybrid photon detectors (HPDs) with matched segmentation and integrated readout electronics. The HPDs read out the two ends of the scintillator package. Both excellent spatial (x, y, z) and energy resolution are obtained. The concept allows enhancing the detection efficiency by reconstructing a significant fraction of events which underwent Compton scattering in the crystals. The proof of concept will first be demonstrated with yttrium orthoaluminate perovskite (YAP):Ce crystals, but the final design will rely on other scintillators more adequate for PET applications (e.g. LSO:Ce or LaBr{sub 3}:Ce). A promising application of the proposed camera module, which is currently under development, is a high resolution 3D brain PET camera with an axial field-of-view of {approx}15 cm dedicated to brain research. The design philosophy and performance predictions based on analytical calculations and Monte Carlo simulations are presented. Image correction and reconstruction tools required to operate this transmissionless device in a research environment are also discussed. Better or similar performance parameters were obtained compared to other known designs at lower fabrication cost. The axial geometrical concept also seems to be promising for applications such as positron emission mammography.

  17. Feasibility of a novel design of high resolution parallax-free Compton enhanced PET scanner dedicated to brain research

    Science.gov (United States)

    Braem, A.; Chamizo Llatas, M.; Chesi, E.; Correia, J. G.; Garibaldi, F.; Joram, C.; Mathot, S.; Nappi, E.; Ribeiro da Silva, M.; Schoenahl, F.; Séguinot, J.; Weilhammer, P.; Zaidi, H.

    2004-06-01

    A novel concept for a positron emission tomography (PET) camera module is proposed, which provides full 3D reconstruction with high resolution over the total detector volume, free of parallax errors. The key components are a matrix of long scintillator crystals and hybrid photon detectors (HPDs) with matched segmentation and integrated readout electronics. The HPDs read out the two ends of the scintillator package. Both excellent spatial (x, y, z) and energy resolution are obtained. The concept allows enhancing the detection efficiency by reconstructing a significant fraction of events which underwent Compton scattering in the crystals. The proof of concept will first be demonstrated with yttrium orthoaluminate perovskite (YAP):Ce crystals, but the final design will rely on other scintillators more adequate for PET applications (e.g. LSO:Ce or LaBr3:Ce). A promising application of the proposed camera module, which is currently under development, is a high resolution 3D brain PET camera with an axial field-of-view of ~15 cm dedicated to brain research. The design philosophy and performance predictions based on analytical calculations and Monte Carlo simulations are presented. Image correction and reconstruction tools required to operate this transmissionless device in a research environment are also discussed. Better or similar performance parameters were obtained compared to other known designs at lower fabrication cost. The axial geometrical concept also seems to be promising for applications such as positron emission mammography. All the authors are members of the CIMA Collaboration.

  18. The Design of a Drag-Free CubeSat and the Housing for its Gravitational Reference Sensor

    CERN Document Server

    Zanoni, Carlo; Aljadaan, Ahmad; Althubiti, Salman; Balakrishnan, Karthik; Buchman, Sasha; Byer, Robert L; Conklin, John W; Cutler, Grant D; DeBra, Dan; Hultgren, Eric; Lipa, John A; Saraf, Shailendhar; Zoellner, Andreas

    2016-01-01

    A Drag-Free CubeSat mission has been proposed to demonstrate the feasibility of a Gravitational Reference Sensor (GRS) with an optical readout for a 3 units (3U) spacecraft. A purely drag-free object is defined by the absence of all external forces other than gravity, which are shielded by the spacecraft. In a real case, the TM will still be affected by disturbances. Several of them are passively reduced by the design of the TM housing. This system is a thick-walled aluminium box that holds the shadow sensors and shields the TM. The housing has an effect on the mechanical, thermal and magnetic environment around the TM. All of them have been analysed. The mechanical vibrations have to fit the launch environment and the modes have to be outside of the measurement range (0.0001 - 1 Hz). The magnetic field has to be reduced by a 0.01 factor. The temperature difference between internal opposing surfaces, determining pressure on the TM, has to be below 10^-3(1 mHz/f)1/3 K Hz^-1/2. The housing, together with the TM...

  19. 2 MN自由锻造油压机的设计%Design of 2 MN Free Forging Press

    Institute of Scientific and Technical Information of China (English)

    郝兴安; 陈凯

    2012-01-01

    The functions and structural characteristics of the 2 MN free forging press were introduced. The working principle and design characteristics of the hydraulic system of the press were analyzed. After the device is put into use, shock and vibration of the system are small, the pressure regulating and pressure protection are easy to realize. The system is authorized by user.%分绍2 MN自由锻造油压机的功能和结构特点,分析该机液压系统的工作原理和设计特点.该设备投入使用后,系统的冲击和振动较小,易于实现压机的压力调节及压力保护,得到了使用单位的认可.

  20. Design and experimental results of the Nb3Sn double insert for an 18 tesla, 100 mm free bore solenoid

    International Nuclear Information System (INIS)

    A high field, large free bore (more than 100 mm at 4.2 K) solenoid for the LASA Lab of INFN-Milan is almost completed. The Nb3Sn insert, constituted by two coils independently supplied, is designed to provide a central field in excess of 18 tesla when immersed in the background field of 8 tesla when immersed in the background field of 8 tesla generated by a NbTi solenoid of 550 mm room temperature bore (this last solenoid already being in operation). The construction technique--W and R followed by vacuum impregnation--is described and the results of tests and measurements carried out on models wound with the real conductor (a NbSn/Cu Rutherford flat cable) are reported

  1. Free and Open-Source Software is not an Emerging Property but Rather the Result of Studied Design

    CERN Document Server

    Magrassi, Paolo

    2010-01-01

    Free and open source software (FOSS) is considered by many, along with Wikipedia, the proof of an ongoing paradigm shift from hierarchically-managed and market-driven production of knowledge to heterarchical, collaborative and commons-based production styles. In such perspective, it has become common place to refer to FOSS as a manifestation of collective intelligence where deliverables and artefacts emerge by virtue of mere cooperation, with no need for supervising leadership. The paper argues that this assumption is based on limited understanding of the software development process, and may lead to wrong conclusions as to the potential of peer production. The development of a less than trivial piece of software, irrespective of whether it be FOSS or proprietary, is a complex cooperative effort requiring the participation of many (often thousands of) individuals. A subset of the participants always play the role of leading system and subsystem designers, determining architecture and functionality; the rest o...

  2. Hydration Free Energy as a Molecular Descriptor in Drug Design: A Feasibility Study.

    Science.gov (United States)

    Zafar, Ayesha; Reynisson, Jóhannes

    2016-05-01

    In this work the idea was investigated whether calculated hydration energy (ΔGhyd ) can be used as a molecular descriptor in defining promising regions of chemical space for drug design. Calculating ΔGhyd using the Density Solvation Model (SMD) in conjunction with the density functional theory (DFT) gave an excellent correlation with experimental values. Furthermore, calculated ΔGhyd correlates reasonably well with experimental water solubility (r(2) =0.545) and also log P (r(2) =0.530). Three compound collections were used: Known drugs (n=150), drug-like compounds (n=100) and simple organic compounds (n=140). As an approximation only molecules, which do not de/protonate at physiological pH were considered. A relatively broad distribution was seen for the known drugs with an average at -15.3 kcal/mol and a standard deviation of 7.5 kcal/mol. Interestingly, much lower averages were found for the drug-like compounds (-7.5 kcal/mol) and the simple organic compounds (-3.1 kcal/mol) with tighter distributions; 4.3 and 3.2 kcal/mol, respectively. This trend was not observed for these collections when calculated log P and log S values were used. The considerable greater exothermic ΔGhyd average for the known drugs clearly indicates in order to develop a successful drug candidate value of ΔGhyd <-5 kcal/mol or less is preferable. PMID:27492087

  3. Hydration Free Energy as a Molecular Descriptor in Drug Design: A Feasibility Study.

    Science.gov (United States)

    Zafar, Ayesha; Reynisson, Jóhannes

    2016-05-01

    In this work the idea was investigated whether calculated hydration energy (ΔGhyd ) can be used as a molecular descriptor in defining promising regions of chemical space for drug design. Calculating ΔGhyd using the Density Solvation Model (SMD) in conjunction with the density functional theory (DFT) gave an excellent correlation with experimental values. Furthermore, calculated ΔGhyd correlates reasonably well with experimental water solubility (r(2) =0.545) and also log P (r(2) =0.530). Three compound collections were used: Known drugs (n=150), drug-like compounds (n=100) and simple organic compounds (n=140). As an approximation only molecules, which do not de/protonate at physiological pH were considered. A relatively broad distribution was seen for the known drugs with an average at -15.3 kcal/mol and a standard deviation of 7.5 kcal/mol. Interestingly, much lower averages were found for the drug-like compounds (-7.5 kcal/mol) and the simple organic compounds (-3.1 kcal/mol) with tighter distributions; 4.3 and 3.2 kcal/mol, respectively. This trend was not observed for these collections when calculated log P and log S values were used. The considerable greater exothermic ΔGhyd average for the known drugs clearly indicates in order to develop a successful drug candidate value of ΔGhyd <-5 kcal/mol or less is preferable.

  4. Design Intelligent Model-free Hybrid Guidance Controller for Three Dimension Motor

    Directory of Open Access Journals (Sweden)

    Abdol Majid Mirshekaran

    2014-10-01

    Full Text Available The minimum rule base Proportional Integral Derivative (PID Fuzzy hybrid guidance Controller for three dimensions spherical motor is presented in this research. A three dimensions spherical motor is well equipped with conventional control techniques and, in particular, various PID controllers which demonstrate a good performance and successfully solve different guidance problems. Guidance control in a three dimensions spherical motor is performed by the PID controllers producing the control signals which are applied to systems torque. The necessary reference inputs for a PID controller are usually supplied by the system's sensors based on different data. The popularity of PID Fuzzy hybrid guidance Controller can be attributed to their robust performance in a wide range of operating conditions and partly to their functional simplicity. PID methodology has three inputs and if any input is described with seven linguistic values, and any rule has three conditions we will need 343 rules. It is too much work to write 343 rules. In this research the PID-like fuzzy controller can be constructed as a parallel structure of a PD-like fuzzy controller and a conventional PI controller to have the minimum rule base. Linear type PID controller is used to modify PID fuzzy logic theory to design hybrid guidance methodology. This research is used to reduce or eliminate the fuzzy and conventional PID controller problem based on minimum rule base fuzzy logic theory and modified it by PID method to control of spherical motor system and testing of the quality of process control in the simulation environment of MATLAB/SIMULINK Simulator.

  5. Fabrication of novel electrolyte-layer free fuel cell with semi-ionic conductor (Ba0.5Sr0.5Co0.8Fe0.2O3-δ- Sm0.2Ce0.8O1.9) and Schottky barrier

    Science.gov (United States)

    Afzal, Muhammad; Saleemi, Mohsin; Wang, Baoyuan; Xia, Chen; Zhang, Wei; He, Yunjuan; Jayasuriya, Jeevan; Zhu, Bin

    2016-10-01

    Perovskite Ba0.5Sr0.5Co0.8Fe0.2O3-δ (BSCF) is synthesized via a chemical co-precipitation technique for a low temperature solid oxide fuel cell (LTSOFC) (300-600 °C) and electrolyte-layer free fuel cell (EFFC) in a comprehensive study. The EFFC with a homogeneous mixture of samarium doped ceria (SDC): BSCF (60%:40% by weight) which is rather similar to the cathode (SDC: BSCF in 50%:50% by weight) used for a three layer SOFC demonstrates peak power densities up to 655 mW/cm2, while a three layer (anode/electrolyte/cathode) SOFC has reached only 425 mW/cm2 at 550 °C. Chemical phase, crystal structure and morphology of the as-prepared sample are characterized by X-ray diffraction and field emission scanning electron microscopy coupled with energy dispersive spectroscopy. The electrochemical performances of 3-layer SOFC and EFFC are studied by electrochemical impedance spectroscopy (EIS). As-prepared BSCF has exhibited a maximum conductivity above 300 S/cm at 550 °C. High performance of the EFFC device corresponds to a balanced combination between ionic and electronic (holes) conduction characteristic. The Schottky barrier prevents the EFFC from the electronic short circuiting problem which also enhances power output. The results provide a new way to produce highly effective cathode materials for LTSOFC and semiconductor designs for EFFC functions using a semiconducting-ionic material.

  6. Governance Structures of Free/Open Source Software Development: Examining the role of modular product design as a governance mechanism in the FreeBSD Project

    OpenAIRE

    Dafermos, G.

    2012-01-01

    My dissertation looks at the Governance Structures of Free/Open Source (FOSS) Development, based on a case study of FreeBSD, a large FOSS project. More specifically, it examines 3 well-known theories. The 1st theory [decreasing returns to scale] holds that increasing the number of persons working together results in a productivity drop due to (a) increased coordination costs and (b) reduced individual motivation. The 2nd theory [iron law of oligarchy] holds that a group's ability to self-orga...

  7. Designing a location update strategy for free-moving and network-constrained objects with varying velocity

    Institute of Scientific and Technical Information of China (English)

    Yuan-Ko HUANG; Lien-Fa LIN

    2014-01-01

    Spatio-temporal databases aim at appropriately managing moving objects so as to support various types of queries. While much research has been conducted on developing query processing techniques, less effort has been made to address the issue of when and how to update location information of moving objects. Previous work shifts the workload of processing updates to each object which usually has limited CPU and battery capacities. This results in a tremendous processing overhead for each moving object. In this paper, we focus on designing efficient update strategies for two important types of moving objects, free-moving objects (FMOs) and network-constrained objects (NCOs), which are classified based on object movement models. For FMOs, we develop a novel update strategy, namely the FMO update strategy (FMOUS), to explicitly indicate a time point at which the object needs to update location information. As each object knows in advance when to update (meaning that it does not have to continuously check), the processing overhead can be greatly reduced. In addition, the FMO update procedure (FMOUP) is designed to efficiently process the updates issued from moving objects. Similarly, for NCOs, we propose the NCO update strategy (NCOUS) and the NCO update procedure (NCOUP) to inform each object when and how to update location information. Exten-sive experiments are conducted to demonstrate the effectiveness and efficiency of the proposed update strategies.

  8. Design of the extraction arc for the 2{sup nd} beam line of the free-electron laser FLASH

    Energy Technology Data Exchange (ETDEWEB)

    Scholz, Matthias

    2014-01-15

    In this thesis, I deal with the design of the extraction arc for the second beam line of FLASH, an FEL (Free-Electron Laser) user facility at DESY Hamburg. Both beam lines will use the same linear accelerator and their separation will take place behind the last accelerating module. I present the constraints for the extraction arc given by the beam line layout of the existing machine, by the building environment of the new beam line and in particular, by coherent synchrotron radiation (CSR). The impact from CSR is presented, and I show how to mitigate these effects and what that means for the beam line design. The optimization of the extraction arc was done applying the downhill simplex algorithm which is presented, first in its basic form to explain the operation principle and then in a more advanced version as used in the applied program. I introduce in this thesis the final layout of the extraction arc including the following matching section. This layout fulfills all given constraints and can provide the required electron beam quality for FEL operation. In order to prove this, I present start-to-end simulations for different bunch charges and for two different wavelengths.

  9. Student attitudes toward science and sciencerelated careers: A program designed to promote a stimulating gender-free learning environment

    Science.gov (United States)

    Mason, Cheryl L.; Butler Kahle, Jane

    A project designed to foster the full and fair participation of girls in high-school science classes addressed obstacles, both perceived and actual, to equal participation. In order to modify existing classroom techniques and environments, a Teacher Intervention Program was designed. By means of a workshop and periodic personal communications, teachers were sensitized to the importance of a stimulating, gender-free learning environment. In addition, they were presented with a variety of methods and materials which had been shown to encourage girls in science. Twelve teachers, who were selected randomly, taught in diverse communities throughout one Midwestern state. The subjects tested were students in 24 general biology classes taught by the 12 teachers. Although both qualitative and quantitative measures were used during the research, only the quantitative results are discussed in this paper. Using ANOVA's, treatment group by student sex, a comparison of the mean scores was made for all students, as well as for all females and for all males. The results indicated that the experimental group, compared to the control group, had significantly higher mean scores on tests of attitudes toward science, perceptions of science, extracurricular science activities, and interest in a science-related career.

  10. Design configurations affecting flow pattern and solids accumulation in horizontal free water and subsurface flow constructed wetlands.

    Science.gov (United States)

    Pedescoll, A; Sidrach-Cardona, R; Sánchez, J C; Carretero, J; Garfi, M; Bécares, E

    2013-03-01

    The aim of this study was to evaluate the effect of different horizontal constructed wetland (CW) design parameters on solids distribution, loss of hydraulic conductivity over time and hydraulic behaviour, in order to assess clogging processes in wetlands. For this purpose, an experimental plant with eight CWs was built at mesocosm scale. Each CW presented a different design characteristic, and the most common CW configurations were all represented: free water surface flow (FWS) with different effluent pipe locations, FWS with floating macrophytes and subsurface flow (SSF), and the presence of plants and specific species (Typha angustifolia and Phragmites australis) was also considered. The loss of the hydraulic conductivity of gravel was greatly influenced by the presence of plants and organic load (representing a loss of 20% and c.a. 10% in planted wetlands and an overloaded system, respectively). Cattail seems to have a greater effect on the development of clogging since its below-ground biomass weighed twice as much as that of common reed. Hydraulic behaviour was greatly influenced by the presence of a gravel matrix and the outlet pipe position. In strict SSF CW, the water was forced to cross the gravel and tended to flow diagonally from the top inlet to the bottom outlet (where the inlet and outlet pipes were located). However, when FWS was considered, water preferentially flowed above the gravel, thus losing half the effective volume of the system. Only the presence of plants seemed to help the water flow partially within the gravel matrix. PMID:23286990

  11. Design of the extraction arc for the 2nd beam line of the free-electron laser FLASH

    International Nuclear Information System (INIS)

    In this thesis, I deal with the design of the extraction arc for the second beam line of FLASH, an FEL (Free-Electron Laser) user facility at DESY Hamburg. Both beam lines will use the same linear accelerator and their separation will take place behind the last accelerating module. I present the constraints for the extraction arc given by the beam line layout of the existing machine, by the building environment of the new beam line and in particular, by coherent synchrotron radiation (CSR). The impact from CSR is presented, and I show how to mitigate these effects and what that means for the beam line design. The optimization of the extraction arc was done applying the downhill simplex algorithm which is presented, first in its basic form to explain the operation principle and then in a more advanced version as used in the applied program. I introduce in this thesis the final layout of the extraction arc including the following matching section. This layout fulfills all given constraints and can provide the required electron beam quality for FEL operation. In order to prove this, I present start-to-end simulations for different bunch charges and for two different wavelengths.

  12. Free electron lasers for 13nm EUV lithography: RF design strategies to minimise investment and operational costs

    Science.gov (United States)

    Keens, Simon; Rossa, Bernhard; Frei, Marcel

    2016-03-01

    As the semiconductor industry proceeds to develop ever better sources of extreme ultraviolet (EUV) light for photolithography applications, two distinct technologies have come to prominence: Tin-plasma and free electron laser (FEL) sources. Tin plasma sources have been in development within the industry for many years, and have been widely reported. Meanwhile, FELs represent the most promising alternative to create high power EUV frequencies and, while tin-plasma source development has been ongoing, such lasers have been continuously developed by academic institutions for use in fundamental research programmes in conjunction with universities and national scientific institutions. This paper follows developments in the field of academic FELs, and presents information regarding novel technologies, specifically in the area of RF design strategy, that may be incorporated into future industrial FEL systems for EUV lithography in order to minimize the necessary investment and operational costs. It goes on to try to assess the cost-benefit of an alternate RF design strategy, based upon previous studies.

  13. Exploiting deterministic maintenance opportunity windows created by conservative engineering design rules that result in free time locked into large high-speed coupled production lines with finite buffers

    Directory of Open Access Journals (Sweden)

    Durandt, Casper

    2016-08-01

    Full Text Available Conservative engineering design rules for large serial coupled production processes result in machines having locked-in free time (also called ‘critical downtime’ or ‘maintenance opportunity windows’, which cause idle time if not used. Operators are not able to assess a large production process holistically, and so may not be aware that they form the current bottleneck – or that they have free time available due to interruptions elsewhere. A real-time method is developed to accurately calculate and display free time in location and magnitude, and efficiency improvements are demonstrated in large-scale production runs.

  14. Design and characterization of the DC acceleration and transport system required for the FOM 1 MW free electron maser experiment

    Energy Technology Data Exchange (ETDEWEB)

    Caplan, M. [Lawrence Livermore National Lab., CA (United States); Urbanus, W.H.; Geer, C. van der [FOM-Institut voor Plasma Fysica, Nieuwegein (Netherlands)] [and others

    1995-12-31

    A Free Electron Maser (FEM) has been constructed and is soon to be tested at the FOM Institute (Rijnhuizen) Netherlands with the goal of producing 1 MW long pulse to CW microwave output in the range 130 GHz to 250 GHz. The design uses a DC beam system in a depressed collector configuration in order to make the overall wall plug efficiency 50%. The high voltage ({approximately} 2 MeV) power supply provides only the body interception current ({approximately} 30 mA) while the 12 amp beam current is supplied by the 100-200 keV collector supplies. Some of the design features to ensure low interception current, which is critical to long pulse (CW) operation are: (1) DC beam in-line transport and acceleration system, (2) emittance conserving solenoid focusing system, (3) halo suppression techniques at cathode edge, and (4) very low beam fill factor (<20%). A relativistic version of the Herman Optical theory developed for microwave tubes is used to determine current distribution functions everywhere along the beam from the electron gun, through the DC accelerator and transport system to the wiggler. This theory takes into account thermals far out on the gaussian tail which translates into beam current far outside the ideal beam edge. This theory is applied to the FOM beam line design to predict a series of beam envelope contours containing various percentages of total beam current up to 99.9%. Predictions of body interception current due to finite emittance (effective temperature) are presented and compared with measured experimental results.

  15. A study on the optimum core design of small/medium sized reactor for soluble boron free operation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong Kyung; Kim, S.Y.; Han, C.Y.; Park, S.I. [Hanyang University, Seoul (Korea); Lee, U.C.; Jang, J.W. [Seoul National University, Seoul (Korea)

    1999-04-01

    The purpose of this work is to perform an optimization of elementary technologies in core management, reactor power control, and safety evaluation for SBF(Soluble Boron Free) operation in small/medium sized reactor. Through a sensitivity study on the nuclear characteristics of various BP rods in SBF core, an evaluation of predominant characteristics in SBF core about the BP rods was carried out, and optimized form of BP rod suitable for SBF operation was introduced. For the prevention of inherently skewed axial power distribution in SBF core, the simplest form of fuel assembly axial zoning was developed. The validity of the elementary technologies was examined by applying these to the 600MWe AP600 reactor designed by Westinghouse. FPM-SBF(Fast Predictor Module for Soluble Boron Free Operation) was developed for automatic control of the SBF core, which predicts critical control rods positions for compensating reactivity effects and satisfying desired axial offset, and control logic was established by applying Mode K to the SBF core. Through the simulation of daily load following operation of benchmark calculation for predicting ability of FPM-SBF was performed, and the feasibility of load following operation for SBF core was illustrated. Furthermore, a robust scheme with neural networks was presented for nuclear power shape control. In the safety evaluation of the SBF core, the quantitative analysis about two limiting accidents, steam line break accident and RCCA ejection accident was carried out, and, as a result, sufficient safety of the SBF core was secured. (author). 40 refs., 115 figs., 15 tabs.

  16. Solid-phase based on-chip DNA purification through a valve-free stepwise injection of multiple reagents employing centrifugal force combined with a hydrophobic capillary barrier pressure.

    Science.gov (United States)

    Zhang, Hainan; Tran, Hong Hanh; Chung, Bong Hyun; Lee, Nae Yoon

    2013-03-21

    In this paper, we demonstrate a simple technique for sequentially introducing multiple sample liquids into microchannels driven by centrifugal force combined with a hydrophobic barrier pressure and apply the technique for performing solid-phase based on-chip DNA purification. Three microchannels with varying widths, all equipped with independent sample reservoirs at the inlets, were fabricated on a hydrophobic elastomer, poly(dimethylsiloxane) (PDMS). First, glass beads were packed inside the reaction chamber, and a whole cell containing the DNA extract was introduced into the widest channel by applying centrifugal force for physical adsorption of the DNA onto the glass beads. Next, washing and elution solutions were sequentially introduced into the intermediate and narrowest microchannels, respectively, by gradually increasing the amount of centrifugal force. Through a precise manipulation of the centrifugal force, the DNA adsorbed onto the glass beads was successfully washed and eluted in a continuous manner without the need to introduce each solution manually. A stepwise injection of liquids was successfully demonstrated using multiple ink solutions, the results of which corresponded well with the theoretical analyses. As a practical application, the D1S80 locus of human genomic DNA, which is widely used for forensic purposes, was successfully purified using the microdevice introduced in this study, as demonstrated through successful target amplification. This will pave the way for the construction of a control-free valve system for realizing on-chip DNA purification, which is one of the most labor-intensive and hard-to-miniaturize components, on a greatly simplified and miniaturized platform employing hydrophobic PDMS.

  17. Barriers to Physical Activity Among Gay Men.

    Science.gov (United States)

    Cary, Miranda A; Brittain, Danielle R; Dinger, Mary K; Ford, Melissa L; Cain, Meagan; Sharp, Teresa A

    2016-09-01

    Gay men may not be physically active at recommended levels to achieve health benefits. Thus, a need exists to identify general (i.e., common across populations) and population-specific barriers that hinder or stop gay men from participating in physical activity (PA). Salient barriers may be identified through the extent each barrier limits PA (i.e., barrier limitation) and the level of one's confidence to overcome barriers and engage in PA (i.e., self-regulatory efficacy). The purposes of this study were to (1) provide a description of general and population-specific barriers to PA among sufficiently and insufficiently active gay men, (2) identify barrier limitation and self-regulatory efficacy for the reported barriers, and (3) examine the associations between meeting the current PA recommendation, barrier limitation, and self-regulatory efficacy. Participants were 108 self-identified gay males aged 21 to 64 years who completed a web-based survey. A total of 35 general barriers and no population-specific barriers were identified by the sufficiently and insufficiently active groups. The sufficiently active group reported higher self-regulatory efficacy and lower barrier limitation for nearly all reported barriers. A binary logistic regression used to examine the associations between PA, barrier limitation, and self-regulatory efficacy was statistically significant, χ(2)(2, N = 108) = 19.26, p < .0001, R(2) = .16. Only barrier limitation significantly contributed to the model. Future research should continue to examine barriers to PA among gay men to determine whether an intervention needs to be designed specifically for gay men or whether a one-size-fits-all intervention would be effective in helping all men overcome common barriers to engaging in PA. PMID:25643585

  18. Energy barriers, entropy barriers, and non-Arrhenius behavior in a minimal glassy model

    Science.gov (United States)

    Du, Xin; Weeks, Eric R.

    2016-06-01

    We study glassy dynamics using a simulation of three soft Brownian particles confined to a two-dimensional circular region. If the circular region is large, the disks freely rearrange, but rearrangements are rarer for smaller system sizes. We directly measure a one-dimensional free-energy landscape characterizing the dynamics. This landscape has two local minima corresponding to the two distinct disk configurations, separated by a free-energy barrier that governs the rearrangement rate. We study several different interaction potentials and demonstrate that the free-energy barrier is composed of a potential-energy barrier and an entropic barrier. The heights of both of these barriers depend on temperature and system size, demonstrating how non-Arrhenius behavior can arise close to the glass transition.

  19. Feasibility of a novel design of high resolution parallax-free Compton enhanced PET scanner dedicated to brain research

    CERN Document Server

    Braem, André; Chesi, Enrico Guido; Correia, J G; Garibaldi, F; Joram, C; Mathot, S; Nappi, E; Ribeiro da Silva, M; Schoenahl, F; Séguinot, Jacques; Weilhammer, P; Zaidi, H

    2004-01-01

    A novel concept for a positron emission tomography (PET) camera module is proposed, which provides full 3D reconstruction with high resolution over the total detector volume, free of parallax errors. The key components are a matrix of long scintillator crystals and hybrid photon detectors (HPDs) with matched segmentation and integrated readout electronics. The HPDs read out the two ends of the scintillator package. Both excellent spatial (x, y, z) and energy resolution are obtained. The concept allows enhancing the detection efficiency by reconstructing a significant fraction of events which underwent Compton scattering in the crystals. The proof of concept will first be demonstrated with yttrium orthoaluminate perovskite (YAP):Ce crystals, but the final design will rely on other scintillators more adequate for PET applications (e.g. LSO:Ce or LaBr /sub 3/:Ce). A promising application of the proposed camera module, which is currently under development, is a high resolution 3D brain PET camera with an axial fi...

  20. Coastal Barrier Resource Areas, Barrier Beaches; s44nbb94; Barrier beaches on the south coast of RI with levels of development as designated by the RI coastal resources management council. Beach zone desginations were hand drafted on photo enlarged source maps and manually digitized, Published in 1995, 1:24000 (1in=2000ft) scale, State of Rhode Island and Providence Plantations.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Coastal Barrier Resource Areas dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Hardcopy Maps information as of 1995. It is...

  1. Cylindrical air flow reversal barrier

    Energy Technology Data Exchange (ETDEWEB)

    Woznica, C.; Rodziewicz, M.

    1988-06-01

    Describes an innovative design introduced in the ZMP mine in Zory for quick reversal of ventilation air flow. Geologic mining conditions at the 705 m deep horizon, where the barrier was built, are described. According to the design used until now, a reversal system consisted of safety barriers, ventilation air locks, a ventilation bridge and stopping needed in case of a fire when air flow direction must be reversed. Nine air locks and an expensive concrete ventilation bridge were needed and the air locks had to be operated at 8 points of the region to effect reversal. The new design consists of a 2-storey cylindrical barrier which also fulfills the function of a ventilation bridge. It can be manually or remotely operated by a mechanical or pneumatic system. Tests showed that the new barrier permits immediate air flow reversal while retaining 60% of the original air, which is important in the case of fire and methane hazards. It permits improved seam panelling and splitting of pillars and brings an economy of about 40 million zlotys in construction cost. Design and operation of the barrier is illustrated and ventilation air circulation is explained. 7 figs.

  2. Cold-air performance of free-power turbine designed for 112-kilowatt automotive gas-turbine engine. 1: Design Stator-vane-chord setting angle of 35 deg

    Science.gov (United States)

    Kofskey, M. G.; Nusbaum, W. J.

    1978-01-01

    A cold air experimental investigation of a free power turbine designed for a 112-kW automotive gas-turbine was made over a range of speeds from 0 to 130 percent of design equivalent speeds and over a range of pressure ratio from 1.11 to 2.45. Results are presented in terms of equivalent power, torque, mass flow, and efficiency for the design power point setting of the variable stator.

  3. Sensing of EGTA Mediated Barrier Tissue Disruption with an Organic Transistor

    Directory of Open Access Journals (Sweden)

    Scherrine Tria

    2013-01-01

    Full Text Available Barrier tissue protects the body against external factors by restricting the passage of molecules. The gastrointestinal epithelium is an example of barrier tissue with the primary purpose of allowing the passage of ions and nutrients, while restricting the passage of pathogens and toxins. It is well known that the loss of barrier function can be instigated by a decrease in extracellular calcium levels, leading to changes in protein conformation and an increase in paracellular transport. In this study, ethylene glycol-bis(beta-aminoethyl ether-N,N,N',N'-tetra acetic acid (EGTA, a calcium chelator, was used to disrupt the gastrointestinal epithelial barrier. The effect of EGTA on barrier tissue was monitored by a novel label-free method based on an organic electrochemical transistor (OECT integrated with living cells and validated against conventional methods for measuring barrier tissue integrity. We demonstrate that the OECT can detect breaches in barrier tissue upon exposure to EGTA with the same sensitivity as existing methods but with increased temporal resolution. Due to the potential of low cost processing techniques and the flexibility in design associated with organic electronics, the OECT has great potential for high-throughput, disposable sensing and diagnostics.

  4. Effect of heterostructure design on current-voltage characteristics in AlxGa1-xN/GaN double-barriers resonant tunneling diode

    Science.gov (United States)

    Boucherit, M.; Soltani, A.; Rousseau, M.; Farvacque, J.-L.; DeJaeger, J.-C.

    2012-12-01

    Ballistic transport in double-barriers resonant tunneling diodes based on GaN is investigated in this work using the non-equilibrium Green's functions formalism. The electron density of states, the electrons concentration, and the current-voltage characteristics are calculated taking into account the internal electric field induced in the AlxGa1-xN/GaN heterostructures. The effect of the geometrical parameters on the evolution of the current resonances characteristics was analyzed qualitatively by varying GaN quantum well width, thicknesses and height of the AlxGa1-xN barriers.

  5. Design of a machine for the universal non-contact measurement of large free-form optics with 30 nm uncertainty

    NARCIS (Netherlands)

    Henselmans, R.; Rosielle, P.C.J.N.; Steinbuch, M.; Saunders, I.; Bergmans, R.

    2005-01-01

    A new universal non-contact measurement machine design for measuring free-form optics with 30 nm expanded uncertainty is presented. In the cylindrical machine concept, an optical probe with 5 mm range is positioned over the surface by a motion system. Due to a 2nd order error effect when measuring s

  6. Developement of serum-free media in CHO-DG44 cells using a central composite statistical design.

    Science.gov (United States)

    Parampalli, Ananth; Eskridge, Kent; Smith, Leonard; Meagher, Michael M; Mowry, Mark C; Subramanian, Anuradha

    2007-05-01

    A serum free medium was developed for the production of recombinant antibody against Botulinum A (BoNTA) using dihydrofolate reductase deficient Chinese Hamster Ovary Cells (CHO-DG44) in suspension culture. An initial control basal medium was prepared, which was similar in composition to HAM's F12: IMDM (1:1) supplemented with insulin, transeferrin, selenium and a lipid mixture. The vitamin concentration of the basal medium was twice that of HAM's F12: IMDM (1:1). CHO-DG44 cells expressing S25 antibody grew from 2 x 10(5) cells to maximum cell density of 1.04 x 10(6) cells/ml after 5 days in this control medium. A central composite design was used to identify optimal levels and interaction among five groups of medium components. These five groups were glutamine, Essential Amino Acids (EAA), Non Essential Amino Acids (NEAA), Insulin, Transferrin, Selenium (ITS), and lipids. Fifty experiments were carried out in four batches, with two controls in each batch. There was little effect of ITS and Lipid concentrations over the range studied, and glutamine concentration showed a strong interaction with EAA. The optimal concentrations of the variables studied were 2.5 mM Glutamine, 7.4 mM (2x) EAA, 1.4 mM (0.5x) NEAA, 1x ITS supplement, 0.7x Lipids supplement. The maximum viable cell density attained in the optimized medium was 1.4 x 10(6) cells/ml, a 35% improvement over the control culture, while the final antibody titer attained was 22 +/- 3.4 mug/mL, a 50% improvement.

  7. Rational Design of Small-Molecule Stabilizers of Spermine Synthase Dimer by Virtual Screening and Free Energy-Based Approach

    Science.gov (United States)

    Zhang, Zhe; Martiny, Virginie; Lagorce, David; Ikeguchi, Yoshihiko; Alexov, Emil; Miteva, Maria A.

    2014-01-01

    Snyder-Robinson Syndrome (SRS) is a rare mental retardation disorder which is caused by the malfunctioning of an enzyme, the spermine synthase (SMS), which functions as a homo-dimer. The malfunctioning of SMS in SRS patients is associated with several identified missense mutations that occur away from the active site. This investigation deals with a particular SRS-causing mutation, the G56S mutation, which was shown computationally and experimentally to destabilize the SMS homo-dimer and thus to abolish SMS enzymatic activity. As a proof-of-concept, we explore the possibility to restore the enzymatic activity of the malfunctioning SMS mutant G56S by stabilizing the dimer through small molecule binding at the mutant homo-dimer interface. For this purpose, we designed an in silico protocol that couples virtual screening and a free binding energy-based approach to identify potential small-molecule binders on the destabilized G56S dimer, with the goal to stabilize it and thus to increase SMS G56S mutant activity. The protocol resulted in extensive list of plausible stabilizers, among which we selected and tested 51 compounds experimentally for their capability to increase SMS G56S mutant enzymatic activity. In silico analysis of the experimentally identified stabilizers suggested five distinctive chemical scaffolds. This investigation suggests that druggable pockets exist in the vicinity of the mutation sites at protein-protein interfaces which can be used to alter the disease-causing effects by small molecule binding. The identified chemical scaffolds are drug-like and can serve as original starting points for development of lead molecules to further rescue the disease-causing effects of the Snyder-Robinson syndrome for which no efficient treatment exists up to now. PMID:25340632

  8. Rational design of small-molecule stabilizers of spermine synthase dimer by virtual screening and free energy-based approach.

    Directory of Open Access Journals (Sweden)

    Zhe Zhang

    Full Text Available Snyder-Robinson Syndrome (SRS is a rare mental retardation disorder which is caused by the malfunctioning of an enzyme, the spermine synthase (SMS, which functions as a homo-dimer. The malfunctioning of SMS in SRS patients is associated with several identified missense mutations that occur away from the active site. This investigation deals with a particular SRS-causing mutation, the G56S mutation, which was shown computationally and experimentally to destabilize the SMS homo-dimer and thus to abolish SMS enzymatic activity. As a proof-of-concept, we explore the possibility to restore the enzymatic activity of the malfunctioning SMS mutant G56S by stabilizing the dimer through small molecule binding at the mutant homo-dimer interface. For this purpose, we designed an in silico protocol that couples virtual screening and a free binding energy-based approach to identify potential small-molecule binders on the destabilized G56S dimer, with the goal to stabilize it and thus to increase SMS G56S mutant activity. The protocol resulted in extensive list of plausible stabilizers, among which we selected and tested 51 compounds experimentally for their capability to increase SMS G56S mutant enzymatic activity. In silico analysis of the experimentally identified stabilizers suggested five distinctive chemical scaffolds. This investigation suggests that druggable pockets exist in the vicinity of the mutation sites at protein-protein interfaces which can be used to alter the disease-causing effects by small molecule binding. The identified chemical scaffolds are drug-like and can serve as original starting points for development of lead molecules to further rescue the disease-causing effects of the Snyder-Robinson syndrome for which no efficient treatment exists up to now.

  9. LONG-TERM PERFORMANCE OF PERMEABLE REACTIVE BARRIERS: LESSONS LEARNED ON DESIGN, CONTAMINANT TREATMENT, LONGEVITY, PERFORMANCE MONITORING AND COST - AN OVERVIEW

    Science.gov (United States)

    An overview of permeable reactive barrier (PRB) performance for field sites in the U.S. was evaluated over the last 10 years by the U.S. Environmental Protection Agencys Office of Research and Development (EPA-ORD) in collaboration with other U.S. federal agencies, consulting co...

  10. Barriers to Physical Activity Among Patients With Type 1 Diabetes

    OpenAIRE

    Brazeau, Anne-Sophie; Rabasa-Lhoret, Rémi; Strychar, Irene; Mircescu, Hortensia

    2008-01-01

    OBJECTIVE—To determine, in an adult population with type 1 diabetes, barriers to regular physical activity using a diabetes-specific barriers measure (the Barriers to Physical Activity in Diabetes [type 1] [BAPAD1] scale) and factors associated with these barriers. RESEARCH DESIGN AND METHODS—One hundred adults with type 1 diabetes answered a questionnaire assessing perceived barriers to physical activity and related factors. A1C was obtained from the medical chart of each individual. RESULTS...

  11. Beam Line Design and Beam Physics Study of Energy Recovery Linac Free Electron Laser at Peking University

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Guimei [Peking Univ., Beijing (China)

    2011-12-31

    Energy recovering linac (ERL) offers an attractive alternative for generating intense beams of charged particles by approaching the operational efficiency of a storage ring while maintaining the superior beam quality typical of a linear accelerator. In ERLs, the decelerated beam cancels the beam loading effects of the accelerated beam with high repetition rate. Therefore, ERLs can, in principle, accelerate very high average currents with only modest amounts of RF power. So the efficiency of RF power to beam is much higher. Furthermore, the energy of beam to dump is lower, so it will reduce dump radiation. With the successful experiments in large maximum-to-injection energy ratio up to 51:1 and high power FEL up to 14kW, the use of ERL, especially combining with superconducting RF technology, provides a potentially powerful new paradigm for generation of the charged particle beams used in MW FEL, synchrotron radiation sources, high-energy electron cooling devices and so on. The 3+1/2 DC-SC photo injector and two 9cell TESLA superconducting cavity for IR SASE FEL in PKU provides a good platform to achieve high average FEL with Energy Recovery. The work of this thesis is on Beam line design and Beam dynamics study of Energy Recovery Linac Free Electron Laser for Peking University. It is the upgrade of PKU facility, which is under construction. With ERL, this facility can work in CW mode, so it can operate high average beam current without RF power constraint in main linac and generate high average FEL power. Moreover, it provides a test facility to study the key technology in ERL. System parameters are optimized for PKU ERL-FEL. The oscillation FEL output power is studied with different bunch charge, transverse emittance, bunch length and energy spread. The theory of optimal RF power and Q{sub ext} with ERL and without ERL is analyzed and applied to PKU injector and linac including microphonic effect. pace charge effect in the injector and merger is studied for beam

  12. Design and Application of FreeRTOS in the Data acquisition and Transmission System%FreeRTOS在数据采集传输系统中的设计与应用

    Institute of Scientific and Technical Information of China (English)

    赵震奇

    2013-01-01

    设计了基于FreeRTOS和STM32F4单片机的数据采集传输板。该采集板可以采集多路开关量和模拟量输入,控制多路开关量输出,本地数据存储功能、RS485串口通信和GPRS无线传输功能。介绍了STM32F0处理器的特点和数据采集板的硬件原理,然后对FreeRTOS嵌入式操作系统进行了移植和应用,并列出了软件实现的要点。%This paper implements the FreeRTOS and STM32F4 single-chip microcomputer data acquisition transmission boards, which have the function of capture multi-channel switch and analog input, control multi-channel switch quantity output, local data storage capabilities, RS485 communication and GPRS wireless transmission. The characteristics of STM32F0 processor and the hardware principle of data acquisition board frame is firstly introduced in this paper, then the transplantation and application of the FreeRTOS embedded operating system is proposed, and the main points of the software design is listed.

  13. Nucleation barrier height in undercooled metallic melts

    Institute of Scientific and Technical Information of China (English)

    Gang WANG; Dechang ZENG; Zhongwu LIU

    2012-01-01

    The phase-field model of a liquid-to-solid transition was constructed where the model parameters were linked quantitatively to the interfacial properties,and the variation of nucleation barrier height in undercooled metallic melts with respect to undercooling was studied respectively based on two kinds of forms of local free energy density.The calculation results show that,with the increase of undercooling,the critical nucleus does not show bulk properties,and the nucleation barrier height decreases gradually and deviates more and more from that predicted by the classical nucleation theory in both cases.The physical spinodal occurs for a specific form of the local free energy density,where the nucleation barrier height vanishes when the undercooling reaches a critical value and the reduced nucleation barrier height can be expressed by a function of the ratio of undercooling to critical undercooling.

  14. Modeling of Photovoltaic Cell Using Free Software Application for Training and Design Circuit in Photovoltaic Solar Energy

    OpenAIRE

    Aparicio, Miguel Pareja; Pelegrí-Sebastiá, José; Sogorb, Tomás; Llario, Vicente

    2013-01-01

    There are numerous studies that develop the mathematical modeling of photovoltaic cells and verified by software. The model presented is based on an equivalent circuit implemented in free software. Free software used is Quite Universal Circuit Simulator (QUCS). QUCS uses a generic diode for adjust the current and voltage curve (IVcurve) at photovoltaic cell. Additionally, you can use equations to define the model of photovoltaic cell and represent the characteristic curves on the same pag...

  15. Systems study on engineered barriers: barrier performance analysis

    International Nuclear Information System (INIS)

    A performance assessment model for multiple barrier packages containing unreprocessed spent fuel has been modified and applied to several package designs. The objective of the study was to develop information to be used in programmatic decision making concerning engineered barrier package design and development. The assessment model, BARIER, was developed in previous tasks of the System Study on Engineered Barriers (SSEB). The new version discussed in this report contains a refined and expanded corrosion rate data base which includes pitting, crack growth, and graphitization as well as bulk corrosion. Corrosion rates for oxic and anoxic conditions at each of the two temperature ranges are supplied. Other improvements include a rigorous treatment of radionuclide release after package failure which includes resistance of damaged barriers and backfill, refined temperature calculations that account for convection and radiation, a subroutine to calculate nuclear gamma radiation field at each barrier surface, refined stress calculations with reduced conservatism and various coding improvements to improve running time and core usage. This report also contains discussion of alternative scenarios to the assumed flooded repository as well as the impact of water exclusion backfills. The model was used to assess post repository closure performance for several designs which were all variation of basic designs from the Spent Unreprocessed Fuel (SURF) program. Many designs were found to delay the onset of leaching by at least a few hundreds of years in all geologic media. Long delay times for radionuclide release were found for packages with a few inches of sorption backfill. Release of uranium, plutonium, and americium was assessed

  16. Systems study on engineered barriers: barrier performance analysis

    Energy Technology Data Exchange (ETDEWEB)

    Stula, R.T.; Albert, T.E.; Kirstein, B.E.; Lester, D.H.

    1980-09-01

    A performance assessment model for multiple barrier packages containing unreprocessed spent fuel has been modified and applied to several package designs. The objective of the study was to develop information to be used in programmatic decision making concerning engineered barrier package design and development. The assessment model, BARIER, was developed in previous tasks of the System Study on Engineered Barriers (SSEB). The new version discussed in this report contains a refined and expanded corrosion rate data base which includes pitting, crack growth, and graphitization as well as bulk corrosion. Corrosion rates for oxic and anoxic conditions at each of the two temperature ranges are supplied. Other improvements include a rigorous treatment of radionuclide release after package failure which includes resistance of damaged barriers and backfill, refined temperature calculations that account for convection and radiation, a subroutine to calculate nuclear gamma radiation field at each barrier surface, refined stress calculations with reduced conservatism and various coding improvements to improve running time and core usage. This report also contains discussion of alternative scenarios to the assumed flooded repository as well as the impact of water exclusion backfills. The model was used to assess post repository closure performance for several designs which were all variation of basic designs from the Spent Unreprocessed Fuel (SURF) program. Many designs were found to delay the onset of leaching by at least a few hundreds of years in all geologic media. Long delay times for radionuclide release were found for packages with a few inches of sorption backfill. Release of uranium, plutonium, and americium was assessed.

  17. K-Basin isolation barrier seal

    International Nuclear Information System (INIS)

    This report documents various aspects of the design, analysis, procurement, and fabrication of the hydraulic seal on the isolation barriers to be installed in the 100-K Area spent nuclear fuel basin. The isolation barrier is used to keep water in the basin in the event of an earthquake

  18. On the design of experiments for determining ternary mixture free energies from static light scattering data using a nonlinear partial differential equation.

    Science.gov (United States)

    Wahle, Chris W; Ross, David S; Thurston, George M

    2012-07-21

    We mathematically design sets of static light scattering experiments to provide for model-independent measurements of ternary liquid mixing free energies to a desired level of accuracy. A parabolic partial differential equation (PDE), linearized from the full nonlinear PDE [D. Ross, G. Thurston, and C. Lutzer, J. Chem. Phys. 129, 064106 (2008)], describes how data noise affects the free energies to be inferred. The linearized PDE creates a net of spacelike characteristic curves and orthogonal, timelike curves in the composition triangle, and this net governs diffusion of information coming from light scattering measurements to the free energy. Free energy perturbations induced by a light scattering perturbation diffuse along the characteristic curves and towards their concave sides, with a diffusivity that is proportional to the local characteristic curvature radius. Consequently, static light scattering can determine mixing free energies in regions with convex characteristic curve boundaries, given suitable boundary data. The dielectric coefficient is a Lyapunov function for the dynamical system whose trajectories are PDE characteristics. Information diffusion is heterogeneous and system-dependent in the composition triangle, since the characteristics depend on molecular interactions and are tangent to liquid-liquid phase separation coexistence loci at critical points. We find scaling relations that link free energy accuracy, total measurement time, the number of samples, and the interpolation method, and identify the key quantitative tradeoffs between devoting time to measuring more samples, or fewer samples more accurately. For each total measurement time there are optimal sample numbers beyond which more will not improve free energy accuracy. We estimate the degree to which many-point interpolation and optimized measurement concentrations can improve accuracy and save time. For a modest light scattering setup, a sample calculation shows that less than two

  19. Development of dielectric-barrier-discharge ionization.

    Science.gov (United States)

    Guo, Cheng'an; Tang, Fei; Chen, Jin; Wang, Xiaohao; Zhang, Sichun; Zhang, Xinrong

    2015-03-01

    Dielectric-barrier-discharge ionization is an ambient-ionization technique. Since its first description in 2007, it has attracted much attention in such fields as biological analysis, food safety, mass-spectrometry imaging, forensic identification, and reaction monitoring for its advantages, e.g., low energy consumption, solvent-free method, and easy miniaturization. In this review a brief introduction to dielectric barrier discharge is provided, and then a detailed introduction to the dielectric-barrier-discharge-ionization technique is given, including instrumentation, applications, and mechanistic studies. Based on the summary of reported work, possible future uses of this type of ionization source are discussed at the end. PMID:25510973

  20. Smart parking barrier

    KAUST Repository

    Alharbi, Abdulrazaq M.

    2016-05-06

    Various methods and systems are provided for smart parking barriers. In one example, among others, a smart parking barrier system includes a movable parking barrier located at one end of a parking space, a barrier drive configured to control positioning of the movable parking barrier, and a parking controller configured to initiate movement of the parking barrier, via the barrier drive. The movable parking barrier can be positioned between a first position that restricts access to the parking space and a second position that allows access to the parking space. The parking controller can initiate movement of the movable parking barrier in response to a positive identification of an individual allowed to use the parking space. The parking controller can identify the individual through, e.g., a RFID tag, a mobile device (e.g., a remote control, smartphone, tablet, etc.), an access card, biometric information, or other appropriate identifier.

  1. Design of Free Parameters of State-Dependent Coefficient Form Based on the Relation between State-Dependent Riccati Inequality and Hamilton Jacobi Inequality

    Science.gov (United States)

    Sakayanagi, Yoshihiro; Nakaura, Shigeki; Sampei, Mitsuji

    The solvable condition of nonlinear H∞ control problems is given by the Hamilton Jacobi inequality (HJI). The state-dependent Riccati inequality (SDRI) is one of the approaches used to solve the HJI. The SDRI contains the state-dependent coefficient (SDC) form of a nonlinear system. The SDC form is not unique. If a poor SDC form is chosen, then there is no solution for the SDRI. In other words, there exist free parameters of the SDC form that affect the solvability of the SDRI. This study focuses on the free parameters of the SDC form. First, a representation of the free parameters of the SDC form is introduced. The solvability of an SDRI is a sufficient condition for that of the related HJI, and the free parameters affect the conservativeness of the SDRI approach. In addition, a new method for designing the free parameters that reduces the conservativeness of the SDRI approach is introduced. Finally, numerical examples to verify the effect of this method are presented.

  2. 《无障碍设施施工验收及维护规范》(GB50642-2011)的解读%EXPLANATION OF CONSTRUCTION ACCEPTANCE AND MAINTENANCE STANDARDS OF THE BARRIER-FREE FACILITIES( GB 50642-2011 )

    Institute of Scientific and Technical Information of China (English)

    吴纪宁

    2012-01-01

    住房和城乡建设部首次发布了国家标准《无障碍设施施工验收及维护规范》(GB50642-2011),该规范共分4章7个附录,主要内容包括总则、术语、无障碍设施的施工验收、无障碍设施的维护等.该规范较好地解决了与相关标准的配套和协调问题,体现了“以人为本,全民共享”的理念.%Ministry of Housing and Urban-Rural Development of the People's Republic of China issues the Construction acceptance and maintenance standards of the harrier-free facilities (GB 50642-2011) for the first time. This Standard covers 4 chapters and 7 annexes, including general, terms, construction acceptance of barrier-free facilities and maintenance of barrier-free facilities, etc. Supporting and harmonization with relevant standards are successfully solved and the concept of human-oriented and nationwide sharing is well expressed.

  3. A conceptual design of the set-up for solid state spectroscopy with free electron laser and insertion device radiation

    CERN Document Server

    Makhov, V N

    2001-01-01

    The set-up for complex solid state spectroscopy with the use of enhanced properties of radiation from insertion devices and free electron lasers is proposed. Very high flux and pulsed properties of radiation from insertion devices and free electron lasers offer the possibility for the use of such powerful techniques as electron paramagnetic resonance (EPR) and optically detected magnetic resonance (ODMR) for the studies of excited states of electronic excitations or defects in solids. The power density of radiation can become high enough for one more method of exited-state spectroscopy: transient optical absorption spectroscopy. The set-up is supposed to combine the EPR/ODMR spectrometer, i.e. cryostat supplied with superconducting magnet and microwave system, and the optical channels for excitation (by radiation from insertion devices or free electron laser) and detection of luminescence (i.e. primary and secondary monochromators). The set-up can be used both for 'conventional' spectroscopy of solids (reflec...

  4. Demonstration of in situ-constructed horizontal soil containment barrier at Fernald

    International Nuclear Information System (INIS)

    A new design of jet grouting tool that can be guided by horizontal well casings and that operates in the horizontal plane has been used for the in situ placement of grout and construction of a prototype horizontal barrier that is free of windows. Jet grouting techniques have been advanced to permit construction of horizontal barriers underneath contaminated soil without having to excavate or disturb the waste. The paper describes progress on the Fernald Environmental Restoration Management Corporation (FERMCO) In Situ Land Containment Project which is sponsored by the US Department of Energy's (DOE) Office of Technology Development (OTD) for DOE's Fernald Environmental Management Project (FEMP). The Fernald project is to demonstrate a novel, enabling technology for the controlled underground placement of horizontal panels of grout, and the joining of adjacent panels to construct practical, extensive barriers. Construction strategy, equipment mechanics and operating details of this new method are described

  5. Miniature free-piston homogeneous charge compression ignition engine-compressor concept - Part I: performance estimation and design considerations unique to small dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Aichlmayr, H.T.; Kittelson, D.B.; Zachariah, M.R. [The University of Minnesota, Minneapolis (United States). Departments of Mechanical Engineering and Chemistry

    2002-10-01

    Research and development activities pertaining to the development of a 10 W, homogeneous charge compression ignition free-piston engine-compressor are presented. Emphasis is place upon the miniature engine concept and design rationale. Also, a crankcase-scavenged, two-stroke engine performance estimation method (slider-crank piston motion) is developed and used to explore the influence of engine operating conditions and geometric parameters on power density and establish plausible design conditions. The minimization of small-scale effects such as enhanced heat transfer, is also explored. (author)

  6. Concept development designer creativity as specific ways of self-identity and the free development of the world

    OpenAIRE

    Рижова, І. С.

    2014-01-01

    The essence of design work, which is the human dimension of nature, as man is a creator designer product which requires appropriate methodological and cultural understanding. Purpose of the paper: to analyze the content of the basic concepts of the creative design process in creating social and cultural dimensions of its form factors - aesthetic, ethical, practical activities in the educational subject and - estetosfery, ecosphere, praksiosfery aimed at identifying creative design specificati...

  7. [Barrier methods of contraception].

    Science.gov (United States)

    Goldsmith, A; Edelman, D A

    1982-01-01

    Vaginal methods of contraception were the earliest types used and some references to them date back to antiquity. Most of the vaginal contraceptive agents identified by the ancient Greeks, Indians, Japanese, and Chinese have been found in modern laboratory tests to have spermicidal properties, but it is doubtful that the methods were fully reliable or were used by many people. During the 19th century the condom, vaginal spermicides, and diaphragm became available. The development of nonoxynol-9 and other nonirritating but effective spermicidal agents improved vaginal contraceptives greatly by the 1950s, but starting in the 1960s newer methods began to replace the vaginal methods. Interest in barrier methods has been reawakened somewhat by concern about the health effects of hormonal methods. At present all barrier methods leave something to be desired. Failure rates of 3-30% for barrier methods in general have been estimated, but the higher rates are believed due to incorrect or inconsistent use. Theoretical failure rates of condoms and diaphragms have been estimated at 3/100 women-years, but in actual use failure rates may reach 15 for condoms and 13 for diaphragms used with spermicides. Use-effectiveness rates are greatly influenced by motivation. For a variety of reasons, the acceptability of barrier methods is low, especially in developing countries. New developments in spermicidal agents include sperm inhibitors, which impede the fertilizing capacity of sperm rather than attempting a spermicidal effect; a number of such agents have been studied and have proven more effective in animal tests than conventional spermicides. Neosampoon, a new spermicidal foam, has attracted an increasing number of users, especially in developing countries. A new condom, made of thin polymers and containing a standard dose of nonoxynol-9, has been designed to dissolve in the vaginal fluid. Further studies are needed of its acceptability, efficacy, and side effects before it becomes

  8. Design and development of low voltage, low current, transient suppressed and ripple free power supply for critical systems

    International Nuclear Information System (INIS)

    This paper gives an insight view of detail implementation of moving average filter for improving the signal to noise ratio and transient suppression. Finally a low voltage (0-5 V) low current (10 mA), ripple free, inherently transient suppressed power supply has been developed for highly critical systems

  9. A quencher-free molecular beacon design based on pyrene excimer fluorescence using pyrene-labeled UNA (unlocked nucleic acid)

    DEFF Research Database (Denmark)

    Karlsen, Kasper Kannegård; Okholm, Anders Hauge; Kjems, Jørgen;

    2013-01-01

    A quencher-free molecular beacon capable of generating pyrene excimer fluorescence has been constructed using strategically positioned pyrene-UNA monomers. Hybridization of a fully complementary RNA target was accompanied by a pyrene excimer emission increase of more than 900%, and detection of RNA...

  10. Drug Delivery Through the Skin: Molecular Simulations of Barrier Lipids to Design more Effective Noninvasive Dermal and Transdermal Delivery Systems for Small Molecules Biologics and Cosmetics

    Energy Technology Data Exchange (ETDEWEB)

    J Torin Huzil; S Sivaloganathan; M Kohandel; M Foldvari

    2011-12-31

    The delivery of drugs through the skin provides a convenient route of administration that is often preferable to injection because it is noninvasive and can typically be self-administered. These two factors alone result in a significant reduction of medical complications and improvement in patient compliance. Unfortunately, a significant obstacle to dermal and transdermal drug delivery alike is the resilient barrier that the epidermal layers of the skin, primarily the stratum corneum, presents for the diffusion of exogenous chemical agents. Further advancement of transdermal drug delivery requires the development of novel delivery systems that are suitable for modern, macromolecular protein and nucleotide therapeutic agents. Significant effort has already been devoted to obtain a functional understanding of the physical barrier properties imparted by the epidermis, specifically the membrane structures of the stratum corneum. However, structural observations of membrane systems are often hindered by low resolutions, making it difficult to resolve the molecular mechanisms related to interactions between lipids found within the stratum corneum. Several models describing the molecular diffusion of drug molecules through the stratum corneum have now been postulated, where chemical permeation enhancers are thought to disrupt the underlying lipid structure, resulting in enhanced permeability. Recent investigations using biphasic vesicles also suggested a possibility for novel mechanisms involving the formation of complex polymorphic lipid phases. In this review, we discuss the advantages and limitations of permeation-enhancing strategies and how computational simulations, at the atomic scale, coupled with physical observations can provide insight into the mechanisms of diffusion through the stratum corneum.

  11. Rational Design of Dipolar Chromophore as an Efficient Dopant-Free Hole-Transporting Material for Perovskite Solar Cells.

    Science.gov (United States)

    Li, Zhong'an; Zhu, Zonglong; Chueh, Chu-Chen; Jo, Sae Byeok; Luo, Jingdong; Jang, Sei-Hum; Jen, Alex K-Y

    2016-09-14

    In this paper, an electron donor-acceptor (D-A) substituted dipolar chromophore (BTPA-TCNE) is developed to serve as an efficient dopant-free hole-transporting material (HTM) for perovskite solar cells (PVSCs). BTPA-TCNE is synthesized via a simple reaction between a triphenylamine-based Michler's base and tetracyanoethylene. This chromophore possesses a zwitterionic resonance structure in the ground state, as evidenced by X-ray crystallography and transient absorption spectroscopies. Moreover, BTPA-TCNE shows an antiparallel molecular packing (i.e., centrosymmetric dimers) in its crystalline state, which cancels out its overall molecular dipole moment to facilitate charge transport. As a result, BTPA-TCNE can be employed as an effective dopant-free HTM to realize an efficient (PCE ≈ 17.0%) PVSC in the conventional n-i-p configuration, outperforming the control device with doped spiro-OMeTAD HTM.

  12. Working Inside for Smoking Elimination (Project W.I.S.E. study design and rationale to prevent return to smoking after release from a smoke free prison

    Directory of Open Access Journals (Sweden)

    Mello Jennifer

    2011-10-01

    Full Text Available Abstract Background Incarcerated individuals suffer disproportionately from the health effects of tobacco smoking due to the high smoking prevalence in this population. In addition there is an over-representation of ethnic and racial minorities, impoverished individuals, and those with mental health and drug addictions in prisons. Increasingly, prisons across the U.S. are becoming smoke free. However, relapse to smoking is common upon release from prison, approaching 90% within a few weeks. No evidence based treatments currently exist to assist individuals to remain abstinent after a period of prolonged, forced abstinence. Methods/Design This paper describes the design and rationale of a randomized clinical trial to enhance smoking abstinence rates among individuals following release from a tobacco free prison. The intervention is six weekly sessions of motivational interviewing and cognitive behavioral therapy initiated approximately six weeks prior to release from prison. The control group views six time matched videos weekly starting about six weeks prior to release. Assessments take place in-person 3 weeks after release and then for non-smokers every 3 months up to 12 months. Smoking status is confirmed by urine cotinine. Discussion Effective interventions are greatly needed to assist these individuals to remain smoke free and reduce health disparities among this socially and economically challenged group. Trial Registration NCT01122589

  13. System design and performance prediction of a free-piston Stirling engine/magnetic coupling/compressor assembly in a gas residential heat pump

    Science.gov (United States)

    Chen, G.; Beale, W. T.

    Based on the previous evaluation of a magnetic coupling and the described system-design targets, a gas fired free piston Stirling engine/magnetic coupling/compressor (FPSE/MC/C) assembly as a power module for a residential heat pump application was designed and analyzed. A porous combustor/FPSE/magnetic coupling/variable gas control spring/reciprocating compressor assembly was the design selected. Based on the system characteristics, design efforts are described on the following issues: (1) design of a combustor allowing low pressure of natural gas supply; (2) the means to achieve engine power-load matching; (3) the method to maintain the assembly as a resonant system tuning over a wide range of operating conditions; (4) the design of an engine/coupling structure to minimize the magnet mass without sacrificing its mechanical properties; and (5) compressor load capacity modulation. The system analysis and the system performance, which is analytically predicted and described, indicate all the system design goals can be met leading to a strong recommendation for further development.

  14. Safety-barrier diagrams

    DEFF Research Database (Denmark)

    Duijm, Nijs Jan

    2007-01-01

    are discussed. A simple method for quantification of safety-barrier diagrams is proposed, including situations where safety barriers depend on shared common elements. It is concluded that safety-barrier diagrams provide a useful framework for an electronic data structure that integrates information from risk......Safety-barrier diagrams and the related so-called "bow-tie" diagrams have become popular methods in risk analysis. This paper describes the syntax and principles for constructing consistent and valid safety-barrier diagrams. The relation with other methods such as fault trees and Bayesian networks...... analysis with operational safety management....

  15. Extremal surface barriers

    Energy Technology Data Exchange (ETDEWEB)

    Engelhardt, Netta; Wall, Aron C. [Department of Physics, University of California,Santa Barbara, CA 93106 (United States)

    2014-03-13

    We present a generic condition for Lorentzian manifolds to have a barrier that limits the reach of boundary-anchored extremal surfaces of arbitrary dimension. We show that any surface with nonpositive extrinsic curvature is a barrier, in the sense that extremal surfaces cannot be continuously deformed past it. Furthermore, the outermost barrier surface has nonnegative extrinsic curvature. Under certain conditions, we show that the existence of trapped surfaces implies a barrier, and conversely. In the context of AdS/CFT, these barriers imply that it is impossible to reconstruct the entire bulk using extremal surfaces. We comment on the implications for the firewall controversy.

  16. Safety- barrier diagrams

    DEFF Research Database (Denmark)

    Duijm, Nijs Jan

    2008-01-01

    Safety-barrier diagrams and the related so-called 'bow-tie' diagrams have become popular methods in risk analysis. This paper describes the syntax and principles for constructing consistent and valid safety-barrier diagrams. The relation of safety-barrier diagrams to other methods such as fault...... trees and Bayesian networks is discussed. A simple method for quantification of safety-barrier diagrams is proposed. It is concluded that safety-barrier diagrams provide a useful framework for an electronic data structure that integrates information from risk analysis with operational safety management....

  17. 基于老年人行为特征的OTC药品包装障碍性设计%OTC Drug Packaging Barrier Design Based on Behavior Characteristics of the Elderly

    Institute of Scientific and Technical Information of China (English)

    刘金萍

    2015-01-01

    Improve the elderly patients with usability for the security of the OTC medicines packaging. Based on the OTC medicines packaging and analysis of the characteristics of the elderly group behavior and the combination of u-sing inverse thinking-barrier design is put forward, to improve the safety and convenience of OTC drug packaging mainly from visual sense, other senses and man-machine design three aspects, .%为提高老年患者对OTC药品包装的安全使用性,本文通过对OTC药品包装和老年群体行为特点的分析,提出运用逆思维——障碍设计的方法进行设计,主要分别从视觉感官、其他感官及人机设计三方面,来提高OTC药品包装的安全便捷性.

  18. Performance Metrics and Design Parameters for a Free-space Communication Link Based on Multiplexing of Multiple Orbital-Angular-Momentum Beams

    CERN Document Server

    Xie, Guodong; Ren, Yongxiong; Huang, Hao; Yan, Yan; Ahmed, Nisar; Zhao, Zhe; Lavery, Martin P J; Ashrafi, Nima; Ashrafi, Solyman; Tur, Moshe; Molisch, Andreas F; Willner, Alan E

    2014-01-01

    We study the design parameters for an orbital angular momentum (OAM) multiplexed free-space data link. Power loss, channel crosstalk and power penalty of the link are analyzed in the case of misalignment between the transmitter and receiver (lateral displacement, receiver angular error, or transmitter pointing error). The relationship among the system power loss and link distance, transmitted beam size and receiver aperture size are discussed based on the beam divergence due to free space propagation. We also describe the trade-offs for different receiver aperture sizes and mode spacing of the transmitted OAM beams under given lateral displacements or receiver angular errors. Through simulations and some experiments, we show that (1) a system with a larger transmitted beam size and a larger receiver aperture is more tolerant to the lateral displacement but less tolerant to the receiver angular error; (2) a system with a larger mode spacing, which uses larger OAM charges, suffers more system power loss but les...

  19. Government Response to the Discovery of a Rabies Virus Reservoir Species on a Previously Designated Rabies-Free Island, Taiwan, 1999-2014.

    Science.gov (United States)

    Chang, S-S; Tsai, H-J; Chang, F-Y; Lee, T-S; Huang, K-C; Fang, K-Y; Wallace, R M; Inoue, S; Fei, C-Y

    2016-08-01

    Taiwan had been considered rabies free since 1961. In 2013, Taiwan confirmed the detection of rabies virus in wild Taiwan ferret-badgers. Up to December 2014, there have been 423 rabies-confirmed ferret-badgers and three cases of spillover infection into non-reservoir hosts. Genetic analysis indicates that TFBV is distinct from all other known rabies virus variants. To date, ferret-badger rabies is known to occur only in China and Taiwan. The temporal dynamics of rabid ferret-badgers in Taiwan suggests that the epizootic appears to have subsided to enzootic levels as of December 2014. According to the current epidemiologic data, there is only one TFBV strain in Taiwan. TFBV is still sequestered to the mountainous regions. Humans are at risk mainly through exposure to the virus from infected domestic meso-carnivores, mainly dogs and cats. Dogs and cats should be vaccinated to establish an immunological barrier to stop the spread of the disease from mountainous regions to domestic meso-carnivores. PMID:26542085

  20. Design and demonstration of ultra-fast W-band photonic transmitter-mixer and detectors for 25 Gbits/sec error-free wireless linking.

    Science.gov (United States)

    Chen, Nan-Wei; Shi, Jin-Wei; Tsai, Hsuan-Ju; Wun, Jhih-Min; Kuo, Fong-Ming; Hesler, Jeffery; Crowe, Thomas W; Bowers, John E

    2012-09-10

    A 25 Gbits/s error-free on-off-keying (OOK) wireless link between an ultra high-speed W-band photonic transmitter-mixer (PTM) and a fast W-band envelope detector is demonstrated. At the transmission end, the high-speed PTM is developed with an active near-ballistic uni-traveling carrier photodiode (NBUTC-PD) integrated with broadband front-end circuitry via the flip-chip bonding technique. Compared to our previous work, the wireless data rate is significantly increased through the improvement on the bandwidth of the front-end circuitry together with the reduction of the intermediate-frequency (IF) driving voltage of the active NBUTC-PD. The demonstrated PTM has a record-wide IF modulation (DC-25 GHz) and optical-to-electrical fractional bandwidths (68-128 GHz, ~67%). At the receiver end, the demodulation is realized with an ultra-fast W-band envelope detector built with a zero-bias Schottky barrier diode with a record wide video bandwidth (37 GHz) and excellent sensitivity. The demonstrated PTM is expected to find applications in multi-gigabit short-range wireless communication.

  1. Synthetic Eelgrass Oil Barrier

    Science.gov (United States)

    Curtis, T. G.

    2013-05-01

    Although surviving in situ micro-organisms eventually consume spilled oil, extensive inundation of shore biota by oil requires cleanup to enable ecological recovery within normal time scales. Although effective in calm seas and quiet waters, oil is advected over and under conventional curtain oil booms by wave actions and currents when seas are running. Most sorbent booms are not reusable, and are usually disposed of in landfills, creating excessive waste. A new concept is proposed for a floating oil barrier, to be positioned off vulnerable coasts, to interdict, contain, and sequester spilled oil, which can then be recovered and the barrier reused. While conventional oil boom designs rely principally on the immiscibility of oil in water and its relative buoyancy, the new concept barrier avoids the pitfalls of the former by taking advantage of the synergistic benefits of numerous fluid and material properties, including: density, buoyancy, elasticity, polarity, and surface area to volume ratio. Modeled after Zostera marina, commonly called eelgrass, the new barrier, referred to as synthetic eelgrass (SE), behaves analogously. Eelgrass has very long narrow, ribbon-like, leaves which support periphyton, a complex matrix of algae and heterotrophic microbes, which position themselves there to extract nutrients from the seawater flowing past them. In an analogous fashion, oil on, or in, seawater, which comes in contact with SE, is adsorbed on the surface and sequestered there. Secured to the bottom, in shoal waters, SE rises to the surface, and, if the tide is low enough, floats on the sea surface down wind, or down current to snare floating oil. The leaves of SE, called filaments, consist of intrinsically buoyant strips of ethylene methyl acrylate, aka EMA. EMA, made of long chain, saturated, hydrocarbon molecules with nearly homogeneous electron charge distributions, is a non-polar material which is oleophilic and hydrophobic. Oil must be in close proximity to the

  2. Turbo码并行无冲突交织器设计%Design on Collision-free Interleaver of Turbo Code

    Institute of Scientific and Technical Information of China (English)

    丘选锋; 赵宏宇

    2013-01-01

    As for the high data-rate transmission, the parallel decoding method can greatly reduce the decoding latency. However, in the parallel decoding method, the random permutation of interleaver may probably result in memory collision problem. A challenge to the design of parallel turbo decoder is the design of collision-free interleavers with the purpose to avoid the memory access collision. This paper proposes a novel algorithm for generating collision-free S-random interleavers of turbo codes. The collision-free S-random interleavers generated by the proposed algorithm could achieve larger spreading factor S and better average code distance than the collision-free row column S-random interleavers by existing algorithm.%并行译码方案能够显著地降低译码延迟,适合于高比特速率传输的通信系统。然而,在turbo码分块并行译码方案中,交织器的随机置换可能引起存储器地址争用问题。因此在分块并行译码方案中要解决的一个关键问题就是设计出能够避免存储器地址争用的并行交织器。这篇文章提出一种新的产生并行无冲突S随机交织器的算法,和现有的无冲突行列S随机交织器相比较,新算法产生的交织器具有较大的延展因子S和平均码字自由距离。

  3. Double-targeted polymersomes and liposomes for multiple barrier crossing.

    Science.gov (United States)

    Sánchez-Purrà, M; Ramos, V; Petrenko, V A; Torchilin, V P; Borrós, S

    2016-09-25

    In order to treat metastasis in the brain, drug delivery systems must overcome multiple physical barriers between the point of administration and the target, such as the Blood-brain barrier, that hinder their free access across them. Multiple targeting approaches arise as a promising alternative to this barrier and target certain tissues inside the brain at a time. Herein, two surface modification methods are presented to obtain dual-targeted vesicle-like carriers functionalized with an MCF-7-specific phage protein and a BBB-specific peptide, providing the system the ability to cross a BBB model, target breast cancer cells and deliver its payload. The aim of this study was to compare new designed polymersomes with liposomes, a well-established delivery vehicle, in terms of drug loading, targeting, release and tumor cell killing. The bilayer structure of both systems allowed the conjugation with different ligands both by insertion and covalent binding. Different behaviour was observed in release, uptake and tumor cell killing corresponding to differences in membrane permeability of both vehicles and type of targeting and ligands' combination. Preliminary results showed that both formulations were able to cross the BBB monolayer without harming it, showing cytotoxic activity in the abluminal compartment. PMID:27498281

  4. Developement of serum-free media in CHO-DG44 cells using a central composite statistical design

    OpenAIRE

    Parampalli, Ananth; Eskridge, Kent; Smith, Leonard; Meagher, Michael M.; Mowry, Mark C.; Subramanian, Anuradha

    2007-01-01

    A serum free medium was developed for the production of recombinant antibody against Botulinum A (BoNTA) using dihydrofolate reductase deficient Chinese Hamster Ovary Cells (CHO-DG44) in suspension culture. An initial control basal medium was prepared, which was similar in composition to HAM’s F12: IMDM (1:1) supplemented with insulin, transeferrin, selenium and a lipid mixture. The vitamin concentration of the basal medium was twice that of HAM’s F12: IMDM (1:1). CHO-DG44 cells expressing S2...

  5. Optimal design of a new spatial 3-DOF parallel robot with respect to a frame-free index

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Optimal design is one of the most important issues in robots. Since the very beginning, the concepts of the Jacobian matrix, manipulability and condition number, which are used successfully in the field of serial robots, have been applied to parallel robots. Unlike serial robots, parallel robots are good for motion/force transmission. Their performance evaluation and design should be correspondingly dif- ferent. This paper is an attempt to optimally design a novel spatial three-degree-of-freedom (3-DOF) parallel robot by using the concept of motion/force transmission. Accordingly, three indices are defined. The suggested indices are independent of any coordinate frame and could be applied to the analysis and design of a parallel robot whose singularities can be identified wholly by using the relative angle between the output and adjacent links, and by using the relative angle between the input and adjacent links.

  6. Optimal design of a new spatial 3-DOF parallel robot with respect to a frame-free index

    Institute of Scientific and Technical Information of China (English)

    WANG JinSong; LIU XinJun; WU Chao

    2009-01-01

    Optimal design is one of the most important issues in robots. Since the very beginning, the concepts of the Jacobian matrix, manipulability and condition number, which are used successfully in the field of serial robots, have been applied to parallel robots. Unlike serial robots, parallel robots are good for motion/force transmission. Their performance evaluation and design should be correspondingly different. This paper is an attempt to optimally design a novel spatial three-degree-of-freedom (3-DOF)parallel robot by using the concept of motion/force transmission. Accordingly, three indices are defined.The suggested indices are independent of any coordinate frame and could be applied to the analysis and design of a parallel robot whose singularities can be identified wholly by using the relative angle between the output and adjacent links, and by using the relative angle between the input and adjacent links.

  7. Synthesizing High-Quality Graphene Membranes for Engineering Diffusion Barriers

    Science.gov (United States)

    Singha Roy, Susmit

    We demonstrate significant advances in the fundamental understanding and engineering of scalable graphene diffusion barriers. Experimental studies have established that defect-free non-scalable graphene is an excellent barrier material, however its scalable counterparts are still well behind in terms of performance. The latter's ability to perform as a barrier membrane is compromised primarily by the presence of three major problems - high density of defects, self-degradation in ambient environment and induced electrochemical oxidation of the underlying material. First, we develop an in-depth understanding of how diffusion occurs through monolayer graphene grown via chemical vapor deposition. It is shown that the atomic membrane is impenetrable in the pristine regions, however it is easily penetrated by oxygen and water at grain boundaries and intrinsic pinholes. Second, we study in detail the self-deterioration of graphene in ambient and quantify the evolution, kinetics, and energetics of the degradation process both in the pristine and intrinsically defective regions of graphene. It is also found that the degradation process is accelerated in the presence of water vapor. Third, we find that the overall defect density of a graphene membrane is primarily determined by the density of its intrinsic pinholes and grain boundaries. We demonstrate that the density on intrinsic pinholes can be significantly reduced by reducing the surface roughness of the growth substrate which is achieved by regulating the pre-growth annealing time and temperature. The density of the grain boundaries can be altered by varying the internucleation distance during the growth of the membrane. Fourth, when graphene is used as a corrosion barrier for metals, we establish that the electrochemical corrosion of the metal can be drastically reduced by adding an ultra-thin electrically insulating layer between the graphene and the metal. In addition, the barrier performance is enhanced greatly by

  8. Binding Free Energy Calculations for Lead Optimization: Assessment of Their Accuracy in an Industrial Drug Design Context.

    Science.gov (United States)

    Homeyer, Nadine; Stoll, Friederike; Hillisch, Alexander; Gohlke, Holger

    2014-08-12

    Correctly ranking compounds according to their computed relative binding affinities will be of great value for decision making in the lead optimization phase of industrial drug discovery. However, the performance of existing computationally demanding binding free energy calculation methods in this context is largely unknown. We analyzed the performance of the molecular mechanics continuum solvent, the linear interaction energy (LIE), and the thermodynamic integration (TI) approach for three sets of compounds from industrial lead optimization projects. The data sets pose challenges typical for this early stage of drug discovery. None of the methods was sufficiently predictive when applied out of the box without considering these challenges. Detailed investigations of failures revealed critical points that are essential for good binding free energy predictions. When data set-specific features were considered accordingly, predictions valuable for lead optimization could be obtained for all approaches but LIE. Our findings lead to clear recommendations for when to use which of the above approaches. Our findings also stress the important role of expert knowledge in this process, not least for estimating the accuracy of prediction results by TI, using indicators such as the size and chemical structure of exchanged groups and the statistical error in the predictions. Such knowledge will be invaluable when it comes to the question which of the TI results can be trusted for decision making.

  9. Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design.

    Science.gov (United States)

    You, Wanli; Huang, Yu-Ming M; Kizhake, Smitha; Natarajan, Amarnath; Chang, Chia-En A

    2016-08-01

    Inhibition of the protein-protein interaction (PPI) mediated by breast-cancer-gene 1 C-terminal (BRCT) is an attractive strategy to sensitize breast and ovarian cancers to chemotherapeutic agents that induce DNA damage. Such inhibitors could also be used for studies to understand the role of this PPI in DNA damage response. However, design of BRCT inhibitors is challenging because of the inherent flexibility associated with this domain. Several studies identified short phosphopeptides as tight BRCT binders. Here we investigated the thermodynamic properties of 18 phosphopeptides or peptide with phosphate mimic and three compounds with phosphate groups binding to BRCT to understand promiscuous molecular recognition and guide inhibitor design. We performed molecular dynamics (MD) simulations to investigate the interactions between inhibitors and BRCT and their dynamic behavior in the free and bound states. MD simulations revealed the key role of loops in altering the shape and size of the binding site to fit various ligands. The mining minima (M2) method was used for calculating binding free energy to explore the driving forces and the fine balance between configuration entropy loss and enthalpy gain. We designed a rigidified ligand, which showed unfavorable experimental binding affinity due to weakened enthalpy. This was because it lacked the ability to rearrange itself upon binding. Investigation of another phosphate group containing compound, C1, suggested that the entropy loss can be reduced by preventing significant narrowing of the energy well and introducing multiple new compound conformations in the bound states. From our computations, we designed an analog of C1 that introduced new intermolecular interactions to strengthen attractions while maintaining small entropic penalty. This study shows that flexible compounds do not always encounter larger entropy penalty, compared with other more rigid binders, and highlights a new strategy for inhibitor design.

  10. Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design

    Science.gov (United States)

    Huang, Yu-ming M.; Kizhake, Smitha; Natarajan, Amarnath; Chang, Chia-en A.

    2016-01-01

    Inhibition of the protein-protein interaction (PPI) mediated by breast-cancer-gene 1 C-terminal (BRCT) is an attractive strategy to sensitize breast and ovarian cancers to chemotherapeutic agents that induce DNA damage. Such inhibitors could also be used for studies to understand the role of this PPI in DNA damage response. However, design of BRCT inhibitors is challenging because of the inherent flexibility associated with this domain. Several studies identified short phosphopeptides as tight BRCT binders. Here we investigated the thermodynamic properties of 18 phosphopeptides or peptide with phosphate mimic and three compounds with phosphate groups binding to BRCT to understand promiscuous molecular recognition and guide inhibitor design. We performed molecular dynamics (MD) simulations to investigate the interactions between inhibitors and BRCT and their dynamic behavior in the free and bound states. MD simulations revealed the key role of loops in altering the shape and size of the binding site to fit various ligands. The mining minima (M2) method was used for calculating binding free energy to explore the driving forces and the fine balance between configuration entropy loss and enthalpy gain. We designed a rigidified ligand, which showed unfavorable experimental binding affinity due to weakened enthalpy. This was because it lacked the ability to rearrange itself upon binding. Investigation of another phosphate group containing compound, C1, suggested that the entropy loss can be reduced by preventing significant narrowing of the energy well and introducing multiple new compound conformations in the bound states. From our computations, we designed an analog of C1 that introduced new intermolecular interactions to strengthen attractions while maintaining small entropic penalty. This study shows that flexible compounds do not always encounter larger entropy penalty, compared with other more rigid binders, and highlights a new strategy for inhibitor design. PMID

  11. Design and operation of a rotating drum radio frequency plasma reactor for the modification of free nanoparticles

    Science.gov (United States)

    Shearer, Jeffrey C.; Fisher, Ellen R.

    2013-06-01

    A rotating drum rf plasma reactor was designed to functionalize the surface of nanoparticles and other unusually shaped substrates through plasma polymerization and surface modification. This proof-of-concept reactor design utilizes plasma polymerized allyl alcohol to add OH functionality to Fe2O3 nanoparticles. The reactor design is adaptable to current plasma hardware, eliminating the need for an independent reactor setup. Plasma polymerization performed on Si wafers, Fe2O3 nanoparticles supported on Si wafers, and freely rotating Fe2O3 nanoparticles demonstrated the utility of the reactor for a multitude of processes. X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy were used to characterize the surface of the substrates prior to and after plasma deposition, and scanning electron microscopy was used to verify that no extensive change in the size or shape of the nanoparticles occurred because of the rotating motion of the reactor. The reactor design was also extended to a non-depositing NH3 plasma modification system to demonstrate the reactor design is effective for multiple plasma processes.

  12. Am 级中央分隔带柔性护栏耐撞性拓扑优化设计%Crashworthiness topology optimization design of Am class median strip cable barrier

    Institute of Scientific and Technical Information of China (English)

    雷正保; 孙祯祥

    2015-01-01

    为了设计出一套满足 Am 级防撞等级的新型中央分隔带柔性护栏,根据国内现有的评价标准,首先基于动态显式有限元方法建立并验证汽车-护栏有限元模型;然后结合元胞自动机的拓扑优化方法以立柱为设计域进行了不同工况下的拓扑优化分析,并提取了“叶片型”立柱拓扑构型;再运用正交试验方法对影响护栏性能的4个设计变量进行研究,获得中央分隔带柔性护栏立柱的最佳尺寸参数;最后对其进行验证分析。分析结果表明,3种法规规定的车型与护栏碰撞过程中,护栏的最大横向偏移量均小于评价标准规定的1000 mm,车体的最大加速度均小于评价标准规定的20g ,满足了碰撞安全性能评价标准要求,故得到的“叶片型”截面立柱能够实现 Am 级防护能力。%In order to develop a new median strip cable barrier to satisfy the Am level,ac-cording to current available evaluation standard,the crashworthiness topology optimization analysis was implemented on the median strip cable barrier by establishing the system of ve-hicle-barrier dynamic display finite element model and combining the optimization method of cellular automaton.Orthogonal design was carried out to study the impact of cable Barrier System’s four design variables ,then to get the optimum parameters of the size for median strip cable barrier system ,at last through three kinds of models by regulations to verify its feasibility.The results show that in the process of three kinds of car colliding with the barri-er,the barrier’s maximum lateral deviation were less than 1 000 mm of the assessment standard,the car’s maximum acceleration were less than 20g of the assessment standard, which satisfies security of the crash standards.We can comfirm design post as able to a-chieve Am class protection.

  13. Injectable barriers for waste isolation

    International Nuclear Information System (INIS)

    In this paper the authors report laboratory work and numerical simulation done in support of development and demonstration of injectable barriers formed from either of two fluids: colloidal silica or polysiloxane. Two principal problems addressed here are control of gel time and control of plume emplacement in the vadose zone. Gel time must be controlled so that the viscosity of the barrier fluid remains low long enough to inject the barrier, but increases soon enough to gel the barrier in place. During injection, the viscosity must be low enough to avoid high injection pressures which could uplift or fracture the formation. To test the grout gel time in the soil, the injection pressure was monitored as grouts were injected into sandpacks. When grout is injected into the vadose zone, it slumps under the influence of gravity, and redistributes due to capillary forces as it gels. The authors have developed a new module for the reservoir simulator TOUGH2 to model grout injection into the vadose zone, taking into account the increase of liquid viscosity as a function of gel concentration and time. They have also developed a model to calculate soil properties after complete solidification of the grout. The numerical model has been used to design and analyze laboratory experiments and field pilot tests. The authors present the results of computer simulations of grout injection, redistribution, and solidification

  14. Injectable barriers for waste isolation

    Energy Technology Data Exchange (ETDEWEB)

    Persoff, P.; Finsterle, S.; Moridis, G.J.; Apps, J.; Pruess, K. [Lawrence Berkeley National Lab., CA (United States). Earth Sciences Div.; Muller, S.J. [Univ. of California, Berkeley, CA (United States). Dept. of Chemical Engineering

    1995-03-01

    In this paper the authors report laboratory work and numerical simulation done in support of development and demonstration of injectable barriers formed from either of two fluids: colloidal silica or polysiloxane. Two principal problems addressed here are control of gel time and control of plume emplacement in the vadose zone. Gel time must be controlled so that the viscosity of the barrier fluid remains low long enough to inject the barrier, but increases soon enough to gel the barrier in place. During injection, the viscosity must be low enough to avoid high injection pressures which could uplift or fracture the formation. To test the grout gel time in the soil, the injection pressure was monitored as grouts were injected into sandpacks. When grout is injected into the vadose zone, it slumps under the influence of gravity, and redistributes due to capillary forces as it gels. The authors have developed a new module for the reservoir simulator TOUGH2 to model grout injection into the vadose zone, taking into account the increase of liquid viscosity as a function of gel concentration and time. They have also developed a model to calculate soil properties after complete solidification of the grout. The numerical model has been used to design and analyze laboratory experiments and field pilot tests. The authors present the results of computer simulations of grout injection, redistribution, and solidification.

  15. Multilayer moisture barrier

    Energy Technology Data Exchange (ETDEWEB)

    Pankow, Joel W; Jorgensen, Gary J; Terwilliger, Kent M; Glick, Stephen H; Isomaki, Nora; Harkonen, Kari; Turkulainen, Tommy

    2015-04-21

    A moisture barrier, device or product having a moisture barrier or a method of fabricating a moisture barrier having at least a polymer layer, and interfacial layer, and a barrier layer. The polymer layer may be fabricated from any suitable polymer including, but not limited to, fluoropolymers such as polyethylene terephthalate (PET) or polyethylene naphthalate (PEN), or ethylene-tetrafluoroethylene (ETFE). The interfacial layer may be formed by atomic layer deposition (ALD). In embodiments featuring an ALD interfacial layer, the deposited interfacial substance may be, but is not limited to, Al.sub.2O.sub.3, AlSiO.sub.x, TiO.sub.2, and an Al.sub.2O.sub.3/TiO.sub.2 laminate. The barrier layer associated with the interfacial layer may be deposited by plasma enhanced chemical vapor deposition (PECVD). The barrier layer may be a SiO.sub.xN.sub.y film.

  16. Nutritional and sensory characteristics of gluten-free quinoa (Chenopodium quinoa Willd)-based cookies development using an experimental mixture design.

    Science.gov (United States)

    Brito, Isabelle L; de Souza, Evandro Leite; Felex, Suênia Samara Santos; Madruga, Marta Suely; Yamashita, Fábio; Magnani, Marciane

    2015-09-01

    The aim of this study was to develop a gluten-free formulation of quinoa (Chenopodium quinoa Willd.)-based cookies using experimental design of mixture to optimize a ternary mixture of quinoa flour, quinoa flakes and corn starch for parameters of colour, specific volume and hardness. Nutritional and sensory aspects of the optimized formulation were also assessed. Corn starch had a positive effect on the lightness of the cookies, but increased amounts of quinoa flour and quinoa flakes in the mixture resulted in darker product. Quinoa flour showed a negative effect on the specific volume, producing less bulky cookies, and quinoa flour and quinoa flakes had a positive synergistic effect on the hardness of the cookies. According the results and considering the desirability profile for colour, hardness and specific volume in gluten-free cookies, the optimized formulation contains 30 % quinoa flour, 25 % quinoa flakes and 45 % corn starch. The quinoa-based cookie obtained was characterized as a product rich in dietary fibre, a good source of essential amino acids, linolenic acid and minerals, with good sensory acceptability. These findings reports for the first time the application of quinoa processed as flour and flakes in mixture with corn starch as an alternative ingredient for formulations of gluten-free cookies-type biscuits. PMID:26345002

  17. Transgene sequences free of CG dinucleotides lead to high level, long-term expression in the lung independent of plasmid backbone design.

    Science.gov (United States)

    Bazzani, Reto P; Pringle, Ian A; Connolly, Mary M; Davies, Lee A; Sumner-Jones, Stephanie G; Schleef, Martin; Hyde, Stephen C; Gill, Deborah R

    2016-07-01

    Non-viral aerosol gene therapy offers great potential for treating chronic lung diseases of the airways such as cystic fibrosis (CF). Early clinical trials showed that transgene expression in the airways was transient whereas maximal duration of transgene expression is essential in order to minimise the frequency of aerosol treatments. Improved vector design, such as careful selection of the promoter/enhancer, can lead to more persistent levels of transgene expression, but multiple factors affect expression in vivo. Following aerosol delivery to the lungs of mice, we measured reporter gene expression from a CpG-free luciferase transgene cassette in the context of both a plasmid and minicircle vector configuration and showed that the vector backbone had no effect on expression. Transgene activity was affected by the vector backbone however, when a similar, but sub-optimal CpG-containing transgene was used, suggesting that aspects of the plasmid backbone had a negative impact on transgene expression. Similar studies were performed in Toll-like receptor-9 (TLR9) knockout mice to investigate a potential role for the TLR9 signalling pathway in detecting CpGs in the vector sequence. Even in the absence of TLR9, persistent expression could only be achieved with a CpG-free transgene. Together, these data indicate that in order to achieve high levels of persistent expression in vivo, a CpG-free transgene cassette is required. PMID:27061267

  18. The blood-tendon barrier: identification and characterisation of a novel tissue barrier in tendon blood vessels.

    Science.gov (United States)

    Lehner, C; Gehwolf, R; Ek, J C; Korntner, S; Bauer, H; Bauer, H C; Traweger, A; Tempfer, H

    2016-01-01

    Tissue barriers function as "gate keepers" between different compartments (usually blood and tissue) and are formed by specialised membrane-associated proteins, localising to the apicolateral plasma membrane domain of epithelial and endothelial cells. By sealing the paracellular space, the free diffusion of solutes and molecules across epithelia and endothelia is impeded. Thereby, tissue barriers contribute to the establishment and maintenance of a distinct internal and external environment, which is crucial during organ development and allows maintenance of an organ-specific homeostatic milieu. So far, various epithelial and endothelial tissue barriers have been described, including the blood-brain barrier, the blood-retina barrier, the blood-testis barrier, the blood-placenta barrier, and the cerebrospinal fluid (CSF)-brain barrier, which are vital for physiological function and any disturbance of these barriers can result in severe organ damage or even death. Here, we describe the identification of a novel barrier, located in the vascular bed of tendons, which we term the blood-tendon barrier (BTB). By using immunohistochemistry, transmission electron microscopy, and tracer studies we demonstrate the presence of a functional endothelial barrier within tendons restricting the passage of large blood-borne molecules into the surrounding tendon tissue. We further provide in vitro evidence that the BTB potentially contributes to the creation of a distinct internal tissue environment impacting upon the proliferation and differentiation of tendon-resident cells, effects which might be fundamental for the onset of tendon pathologies. PMID:27227787

  19. Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis

    Science.gov (United States)

    The development of organic synthesis under sustainable conditions is a primary goal of practicing green chemists who want to prevent pollution and design safer pathways. Although, it is challenging to avoid the use of catalysts, or solvents in all the organic reactions but progre...

  20. Design challenges and guidelines for free-space optical communication links using orbital-angular-momentum multiplexing of multiple beams

    Science.gov (United States)

    Willner, Alan E.; Xie, Guodong; Li, Long; Ren, Yongxiong; Yan, Yan; Ahmed, Nisar; Zhao, Zhe; Wang, Zhe; Liu, Cong; Willner, Asher J.; Ashrafi, Nima; Ashrafi, Solyman; Tur, Moshe; Molisch, Andreas F.

    2016-07-01

    In this paper, recent studies on the potential challenges for an orbital angular momentum (OAM) multiplexing system were reviewed. The design guideline for a practical OAM multiplexing system were investigated in term of (i) the power loss due to the beam divergence and limited-size receiver, and (ii) the channel crosstalk due to the misalignment between the transmitter and receiver.

  1. Free Money, Free Stuff!

    Science.gov (United States)

    Koss, Linda

    2003-01-01

    Provides information on "free money" books so that librarians can help patrons seeking resources for financial help. Discusses where to find information on federal government grants; funding sources for home loans and business start-ups; and health care resources. Lists several publications that may be helpful resources of financial aid. (AEF)

  2. 99mTc complex conjugated to insulin: CNS radio-pharmaceuticals design based on principles of blood-brain barrier transport vector

    Institute of Scientific and Technical Information of China (English)

    LIU Fei; FAN Caiyun; ZHANG Jinming; WANG Wushang; LIU Boli

    2005-01-01

    Hydrophilic 99mTc-EC and nonlipophilic 99mTc- MAMA′-BA complexes, owing to the existing of intact blood-brain barrier (BBB) in vivo, cannot cross from blood to brain. Previous studies showed that insulin is selectively transported by receptor-mediated transcytosis through the brain capillary endothelial wall that makes up the BBB. In this paper, based on the characteristic of the insulin receptor enriched in brain capillary, the complexes of hydrophilic 99mTc-EC and nonlipophilic 99mTc-MAMA′-BA are conjugated to insulin respectively. After purification, the radiochemical purity of 99mTc-EC-insulin and 99mTc-MAMA′- BA-insulin was > 90% and the stability in vitro was good. Expectation for the special formulation can be internalized and endocytosed into the capillary membrane by the vector-mediated brain delivery system, and transported 99mTc-labeled conjugate through the BBB in vivo, thus enhancing brain uptake in mice. The biodistribution results of 99mTc-EC-insulin and 99mTc-MAMA′-BA-insulin in mice indicated that the brain uptake was higher than 99mTc-EC and 99mTc-MAMA′-BA to some extent. The ratios of brain uptake of 99mTc-EC-insulin to 99mTc-EC, 99mTc-MAMA′-BA-insulin to 99mTc-MAMA′-BA were 4―6 at 2 and 3 h post-injection respectively. In conclusion, the given results have illustrated a new way of brain uptake enhancing for nonlipophilic like complexes that have BBB delivery problems. It has a potential value for the ongoing development of 99mTc-labeled radiopharmaceuticals for CNS receptors imaging.

  3. An experimental characterization of damping properties of thermal barrier coatings at elevated temperatures

    Science.gov (United States)

    Easterday, Oliver T.

    Modern gas turbine engines have routinely utilized thermal barrier coatings for the past three decades to coax greater thermodynamic efficiency out of jet engines. In service, it has been noted that these ceramic materials are also effective at suppressing high cycle fatigue in the engine components, increasing their respective fatigue life. Recent efforts have been made to mechanically characterize these materials; this has been a challenge as they are thin coatings, prone to history effects, and are materially nonlinear. Refinement of the apparatus have occurred and it is now desired to characterize them across a range of likely service temperatures. A free-free beam apparatus has been adapted to accomplish this. Important to achieving viable results is the design, analysis, and experimental validation of the chamber in regards to the free-free specimen being heat-able, modally detuned and free-hanging, and the preservation of a non-contacting excitation method. Critical to success is ensuring a near-isothermal heated beam specimen. After successful validation and calibration of the chamber, a common thermal barrier coating, 8-YSZ, was tested, primarily using the free-decay, logarithmic decrement method, using the chamber from 70-900degF. Materially non-linear behavior was observed and findings of material storage modulus and loss coefficient that are consistent with previous studies were obtained. The chamber was also used to characterize the bare metal beam blanks and bond-coat only specimens. The apparatus was found to be sensitive when determining the storage modulus and damping, more so than the baseline configuration. This was due to changes in design to proof it against high temperature. Resulting, it clearly characterized the anisotropic modulus of titanium and determined that bond coating had a negligible contribution to the beam system. Design life criteria with the properties of the coating could now be adopted across a range of temperatures.

  4. Optical system design of a speckle-free ultrafast Red-Green-Blue (RGB) source based on angularly multiplexed second harmonic generation from a TZDW source

    Science.gov (United States)

    Yao, Yuhong; Knox, Wayne H.

    2015-03-01

    We report the optical system design of a novel speckle-free ultrafast Red-Green-Blue (RGB) source based on angularly multiplexed simultaneous second harmonic generation from the efficiently generated Stokes and anti-Stokes pulses from a commercially available photonic crystal fiber (PCF) with two zero dispersion wavelengths (TZDW). We describe the optimized configuration of the TZDW fiber source which supports excitations of dual narrow-band pulses with peak wavelengths at 850 nm, 1260 nm and spectral bandwidths of 23 nm, 26 nm, respectively within 12 cm of commercially available TZDW PCF. The conversion efficiencies are as high as 44% and 33% from the pump source (a custom-built Yb:fiber master-oscillator-power-amplifier). As a result of the nonlinear dynamics of propagation, the dual pulses preserve their ultrashort pulse width (with measured autocorrelation traces of 200 fs and 227 fs,) which eliminates the need for dispersion compensation before harmonic generation. With proper optical design of the free-space harmonic generation system, we achieve milli-Watt power level red, green and blue pulses at 630 nm, 517 nm and 425 nm. Having much broader spectral bandwidths compared to picosecond RGB laser sources, the source is inherently speckle-free due to the ultra-short coherence length (99.4% excitation purities of the three primaries, leading to the coverage of 192% NTSC color gamut (CIE 1976). The reported RGB source features a very simple system geometry, its potential for power scaling is discussed with currently available technologies.

  5. Statistical design and analysis of label-free LC-MS proteomic experiments: a case study of coronary artery disease.

    Science.gov (United States)

    Clough, Timothy; Braun, Siegmund; Fokin, Vladimir; Ott, Ilka; Ragg, Susanne; Schadow, Gunther; Vitek, Olga

    2011-01-01

    This chapter presents a case study, which applies statistical design and analysis to an LC-MS-based -investigation of subjects with coronary artery disease. First, we discuss the principles of statistical -experimental design, and the specification of an Analysis of Variance (ANOVA) model that describes the major sources of variation in the data. Second, we discuss procedures for detecting differentially abundant proteins, estimating protein abundance in individual samples, testing predefined groups of proteins for enrichment in differential abundance, and calculating sample size for a future experiment. The discussion is accompanied by examples of computer code implemented in the open-source statistical software R, which can be followed for an independent implementation of a similar investigation.

  6. Tantalum oxide coatings as candidate environmental barriers

    OpenAIRE

    Moldovan, Monica; Weyant, C. M.; Johnson, D. Lynn; Faber, K. T.

    2004-01-01

    Tantalum (Ta) oxide, due to its high-temperature capabilities and thermal expansion coefficient similar to silicon nitride, is a promising candidate for environmental barriers for silicon (Si) nitride-based ceramics. This paper focuses on the development of plasma-sprayed Ta oxide as an environmental barrier coating for silicon nitride. Using a D-optimal design of experiments, plasma-spray processing variables were optimized to maximize coating density. The effect of processing variables on c...

  7. Frozen soil barriers for hazardous waste confinement

    Energy Technology Data Exchange (ETDEWEB)

    Dash, J.G.; Leger, R. [Univ. of Washington, Seattle, WA (United States); Fu, H.Y. [Univ. of California, Santa Barbara, CA (United States)

    1997-12-31

    Laboratory and full field measurements have demonstrated the effectiveness of artificial ground freezing for the containment of subsurface hazardous and radioactive wastes. Bench tests and a field demonstration have shown that cryogenic barriers are impenetrable to aqueous and non aqueous liquids. As a result of the successful tests the US Department of Energy has designated frozen ground barriers as one of its top ten remediation technologies.

  8. Development of a serum-free medium for in vitro expansion of human cytotoxic T lymphocytes using a statistical design

    Directory of Open Access Journals (Sweden)

    Lee Gyun

    2010-09-01

    Full Text Available Abstract Background Serum-containing medium (SCM, which has a number of poorly defined components with varying concentrations, hampers standardization of lymphocyte cultures. In order to develop a serum-free medium (SFM for the expansion of human lymphocytes from peripheral blood mononuclear cells (PBMCs, a statistical optimization approach based on a fractional factorial method and a response surface method was adopted. A basal medium was prepared by supplementing RPMI1640 medium with insulin, albumin, ferric citrate, ethanolamine, fatty acids, glutamine, sodium pyruvate, 2-mercaptoethanol, 1-thioglycerol, nonessential amino acids, and vitamins. We identified additional positive determinants and their optimal concentrations for cell growth through a statistical analysis. Results From a statistical analysis using the fractional factorial method, cholesterol and polyamine supplement were identified as positive determinants for cell growth. Their optimal concentrations were determined by the response surface method. The maximum viable cell concentration in the developed SFM was enhanced by more than 1.5-fold when compared to that in RPMI1640 supplemented with 10% fetal bovine serum (FBS. Furthermore, a cytotoxicity assay and an enzyme-linked immunospot assay revealed that the effector function of cytotoxic T lymphocytes generated from PBMCs grown in SFM, by stimulation of peptide-presenting dendritic cells, was retained or even better than that in SCM. Conclusions The use of a developed SFM with cholesterol and polyamine supplement for human lymphocyte culture resulted in better growth without loss of cellular function when compared to SCM.

  9. Enhancement of Fusarium head blight detection in free-falling wheat kernels using a bichromatic pulsed LED design

    Science.gov (United States)

    Yang, I.-Chang; Delwiche, Stephen R.; Chen, Suming; Lo, Y. Martin

    2009-02-01

    Fusarium head blight is a worldwide fungal disease of small cereal grains such as wheat that affects the yield, quality, and safety of food and feed products. The current study was implemented to develop more efficient methods for optically detecting Fusarium-damaged (scabby) kernels from normal (sound) wheat kernels. Through development of a high-power pulsed LED (green and red) inspection system, it was found that Fusarium-damaged and normal wheat kernels have different reflected energy responses. Two parameters (slope and r2) from a regression analysis of the green and red responses were used as input parameters in linear discriminant analysis models. The examined factors affecting accuracy were the orientation of the optical probe, the color contrast between normal and Fusarium-damaged kernels, and the manner in which one LED's response is time-matched to the other LED. Whereas commercial high-speed optical sorters are, on average, 50% efficient at removing mold-damaged kernels, this efficiency can rise to 95% or better under more carefully controlled, kernel-at-rest conditions in the laboratory. The current research on free-falling kernels has demonstrated accuracies (>90% for wheat samples of high visual contrast) that approach those of controlled conditions, which will lead to improvements in high-speed optical sorters.

  10. Design and evaluation of lipoprotein resembling curcumin-encapsulated protein-free nanostructured lipid carrier for brain targeting.

    Science.gov (United States)

    Meng, Fanfei; Asghar, Sajid; Xu, Yurui; Wang, Jianping; Jin, Xin; Wang, Zhilin; Wang, Jing; Ping, Qineng; Zhou, Jianping; Xiao, Yanyu

    2016-06-15

    Many nanoparticle matrixes have been demonstrated to be efficient in brain targeting, but there are still certain limitations for them. To overcome the shortcomings of the existing nanoparticulate systems for brain-targeted delivery, a lipoprotein resembling protein-free nanostructured lipid carrier (PS80-NLC) loaded with curcumin was constructed and assessed for in vitro and in vivo performance. Firstly, single factor at a time approach was employed to investigate the effects of various formulation factors. Mean particle sizes of ≤100nm, high entrapment efficiency (EE, about 95%) and drug loading (DL, >3%) were obtained for the optimized formulations. In vitro release studies in the presence of plasma indicated stability of the formulation under physiological condition. Compared with NLC, PS80-NLC showed noticeably higher affinity for bEnd.3 cells (1.56 folds greater than NLC) but with lower uptake in macrophages. The brain coronal sections showed strong and widely distributed fluorescence intensity of PS80-NLC than that of NLC in the cortex. Ex vivo imaging studies further confirmed that PS80-NLC could effectively permeate BBB and preferentially accumulate in the brain (2.38 times greater than NLC). The considerable in vitro and in vivo performance of the safe and biocompatible PS80-NLC makes it a suitable option for further investigations in brain targeted drug delivery.

  11. AN IN-SITU PERMEABLE REACTIVE BARRIER FOR THE TREATMENT OF HEXAVALENT CHROMIUM AND TRICHLOROETHYLENE IN GROUND WATER: VOLUME 1 DESIGN AND INSTALLATION

    Science.gov (United States)

    A 46 m long, 7.3 m deep, and 0.6 m wide permeable subsurface reactive wall was installed at the U.S. Coast Guard (USCG) Support Center, near Elizabeth City, North Carolina, in June 1996. The reactive wall was designed to remediate hexavalent chromium [Cr(VI)] contaminated ground ...

  12. Design of a Free and Open Source Data Processing, Archiving, and Distribution Subsystem for the Ground Receiving Station of the Philippine Scientific Earth Observation Micro-Satellite

    Science.gov (United States)

    Aranas, R. K. D.; Jiao, B. J. D.; Magallon, B. J. P.; Ramos, M. K. F.; Amado, J. A.; Tamondong, A. M.; Tupas, M. E. A.

    2016-06-01

    The Philippines's PHL-Microsat program aims to launch its first earth observation satellite, DIWATA, on the first quarter of 2016. DIWATA's payload consists of a high-precision telescope (HPT), spaceborne multispectral imager (SMI) with liquid crystal tunable filter (LCTF), and a wide field camera (WFC). Once launched, it will provide information about the Philippines, both for disaster and environmental applications. Depending on the need, different remote sensing products will be generated from the microsatellite sensors. This necessitates data processing capability on the ground control segment. Rather than rely on commercial turnkey solutions, the PHL-Microsat team, specifically Project 3:DPAD, opted to design its own ground receiving station data subsystems. This paper describes the design of the data subsystems of the ground receiving station (GRS) for DIWATA. The data subsystems include: data processing subsystem for automatic calibration and georeferencing of raw images as well as the generation of higher level processed data products; data archiving subsystem for storage and backups of both raw and processed data products; and data distribution subsystem for providing a web-based interface and product download facility for the user community. The design covers the conceptual design of the abovementioned subsystems, the free and open source software (FOSS) packages used to implement them, and the challenges encountered in adapting the existing FOSS packages to DIWATA GRS requirements.

  13. Barriers and Facilitators to Being Physically Active on a Rural U.S. Northern Plains American Indian Reservation

    Directory of Open Access Journals (Sweden)

    Lisa Jahns

    2014-11-01

    Full Text Available The objective of the present study was to identify barriers to and facilitators of physical activity among American Indian adults living on a rural, U.S. Northern Plains reservation using the nominal group technique (NGT. NGT is a method of data generation and interpretation that combines aspects of qualitative (free generation of responses and quantitative (systematic ranking of responses methodologies. Adults participated in one of two NGT sessions asking about either barriers to (n = 6, or facilitators of (n = 5, being physically active. Participants nominated and ranked 21 barriers and 18 facilitators. Barriers indicated lack of knowledge of how to fit physical activity into a daily schedule, work, caring for family members, and prioritizing sedentary pursuits. Other responses included environmental barriers such as lack of access and transportation to a gym, unsafe walking conditions, and inclement weather. Facilitators to following recommendations included knowledge of health benefits of physical activity and the perception of physical activity as enjoyable, including feeling good when working out. Environmental facilitators included being outdoors walking and biking as well as parks and exercise facilities. Responses provided direction for locally designed community-based programs to promote facilitators and decrease barriers to individual’s engagement in physical activity.

  14. Catalytic thermal barrier coatings

    Science.gov (United States)

    Kulkarni, Anand A.; Campbell, Christian X.; Subramanian, Ramesh

    2009-06-02

    A catalyst element (30) for high temperature applications such as a gas turbine engine. The catalyst element includes a metal substrate such as a tube (32) having a layer of ceramic thermal barrier coating material (34) disposed on the substrate for thermally insulating the metal substrate from a high temperature fuel/air mixture. The ceramic thermal barrier coating material is formed of a crystal structure populated with base elements but with selected sites of the crystal structure being populated by substitute ions selected to allow the ceramic thermal barrier coating material to catalytically react the fuel-air mixture at a higher rate than would the base compound without the ionic substitutions. Precious metal crystallites may be disposed within the crystal structure to allow the ceramic thermal barrier coating material to catalytically react the fuel-air mixture at a lower light-off temperature than would the ceramic thermal barrier coating material without the precious metal crystallites.

  15. Barriers to accessing surgical care in Pakistan: healthcare barrier model and quantitative systematic review.

    Science.gov (United States)

    Irfan, Furqan B; Irfan, Bismah B; Spiegel, David A

    2012-07-01

    Inadequate access to surgical services results in increased morbidity and mortality from a spectrum of conditions in Pakistan. We employed a modification of Andersen's model of health services utilization and developed a 'Healthcare Barrier Model,' to characterize the barriers to accessing health care in developing countries, using surgical care in Pakistan as a case study. We performed a literature search from MEDLINE, EMBASE, CINAHL, SCOPUS, Global Health Database, and Cochrane Central Register of Controlled Trials, and selected 64 of 3113 references for analysis. Patient-related variables included age (elderly), gender (female), preferential use of alternative health providers (Hakeem, traditional healers, others), personal perceptions regarding disease and potential for treatment, poverty, personal expenses for healthcare, lack of social support, geographic constraints to accessing a health facility, and compromised general health status as it relates to the development of surgical disease. Environmental barriers include deficiencies in governance, the burden of displaced or refugee populations, and aspects of the medicolegal system, which impact treatment and referral. Barriers relating to the health system include deficiencies in capacity (infrastructure, physical resources, human resources) and organization, and inadequate monitoring. Provider-related barriers include deficiencies in knowledge and skills (and ongoing educational opportunities), delays in referral, deficient communication, and deficient numbers of female health providers for female patients. The Healthcare Barrier model addresses this broad spectrum of barriers and is designed to help formulate a framework of healthcare barriers. To overcome these barriers will require a multidisciplinary, multisectoral effort aimed at strengthening the health system. PMID:22079839

  16. Target Group-Specific Design of Student Entrepreneurship Support – A German Example Focusing on Start-Up Motives and Barriers

    OpenAIRE

    Walter Ruda; Martin, Thomas. A.; Benjamin Danko

    2009-01-01

    The reserach project „Foundation and Entrepreneurship of Students“ (GEStstudy)analyzes entrepreneurial criteria and existing cause-effect relationships within thepre-start-up process of students, in order to generate recommended actions for advcancingand improving the design of student entrepreneurship support and entrepreneurshipeducation. This benefits the entrepreneurial activity of the most innovative target group ofstudents and academics and, thus, employment and the competetiveness of t...

  17. 41 CFR 102-76.60 - To which facilities does the Architectural Barriers Act apply?

    Science.gov (United States)

    2010-07-01

    ... PROPERTY 76-DESIGN AND CONSTRUCTION Architectural Barriers Act § 102-76.60 To which facilities does the Architectural Barriers Act apply? (a) The Architectural Barriers Act applies to any facility that is intended... the Architectural Barriers Act apply? 102-76.60 Section 102-76.60 Public Contracts and...

  18. Structural Design of Large Off-free Compressor Valves%大型无油压缩机气阀结构设计

    Institute of Scientific and Technical Information of China (English)

    潘树林; 刘小龙; 伍永强; 欧胜芳

    2013-01-01

    大型无油压缩机排气量大,功率大,气阀安装直径大,气阀内不存在润滑油.针对这些具体情况,讨论能用于大型无油压缩机的气阀结构型式,分析用于大型无油压缩机的带金属阀片气阀、带塑料阀片气阀的结构特点,指出大型无油压缩机气阀结构设计中需要注意的问题.在大型无油压缩机网状阀中采用自弹缓冲片新技术,有效地提高了气阀的可靠性.%Large oil-free compressors have high discharge capacity and power consumption.The diameters for installation of the compressor valves are big.There is no lubricating oil in the valves.According to the situations,structure types of the valves in the large oil-free compressors are discussed.Structural characteristics of the valves with the metal plates and the valves with the plastic plates are analyzed.Noteworthy problems of the structural design of the valves are pointed out.A new technique of self-elastic damping plates is adopted in the plate valves in the large oil-free compressors.The reliability of the valves is effectively improved.

  19. Designed construction and validation of carbon-free porous MnO spheres with hybrid architecture as anodes for lithium-ion batteries.

    Science.gov (United States)

    Remith, Pongilat; Kalaiselvi, Nallathamby

    2016-06-21

    Porous micro/nanostructures of earth abundant and ecobenign metals are emerging as advanced green materials for use in electrochemical energy storage devices. We present here the custom designed construction of a hybrid architecture containing porous MnO microspheres, formed out of hierarchically assembled nanoparticles using a template-free co-precipitation method, wherein the sacrificial template growth of porous spheres has been obtained by a solution mediated and time dependent oxidation strategy. The nanoporous channels in the MnO microspheres and the nanosized primary particles of MnO anodes in synergy increase the electrolyte percolation, resulting in a discharge capacity of 1200 mA h g(-1) at a current density of 50 mA g(-1) and a capacity as high as 450 mA h g(-1) under the 1000 mA g(-1) condition. The study assumes importance based on the fact that engineering of electrode materials is typically challenging, wherein design, preparation and fabrication of tailor-made electrodes with a desirable micro/nanocrystalline assembly play a critical role, especially when recommended for high capacity and high-rate applications in electrochemical energy storage devices. Further, this communication elaborates the designed construction and validation of porous MnO microspheres engineered through a time dependent process protocol as economically viable and environmentally benign anodes for lithium-ion batteries. PMID:27233053

  20. HgCdTe barrier infrared detectors

    Science.gov (United States)

    Kopytko, M.; Rogalski, A.

    2016-05-01

    In the last decade, new strategies to achieve high-operating temperature (HOT) detectors have been proposed, including barrier structures such as nBn devices, unipolar barrier photodiodes, and multistage (cascade) infrared detectors. The ability to tune the positions of the conduction and valence band edges independently in a broken-gap type-II superlattices is especially helpful in the design of unipolar barriers. This idea has been also implemented in HgCdTe ternary material system. However, the implementation of this detector structure in HgCdTe material system is not straightforward due to the existence of a valence band discontinuity (barrier) at the absorber-barrier interface. In this paper we present status of HgCdTe barrier detectors with emphasis on technological progress in fabrication of MOCVD-grown HgCdTe barrier detectors achieved recently at the Institute of Applied Physics, Military University of Technology. Their performance is comparable with state-of-the-art of HgCdTe photodiodes. From the perspective of device fabrication their important technological advantage results from less stringent surface passivation requirements and tolerance to threading dislocations.

  1. Numerical simulations of capillary barrier field tests

    Energy Technology Data Exchange (ETDEWEB)

    Morris, C.E. [Univ. of Wollongong (Australia); Stormont, J.C. [Univ. of New Mexico, Albuquerque, NM (United States)

    1997-12-31

    Numerical simulations of two capillary barrier systems tested in the field were conducted to determine if an unsaturated flow model could accurately represent the observed results. The field data was collected from two 7-m long, 1.2-m thick capillary barriers built on a 10% grade that were being tested to investigate their ability to laterally divert water downslope. One system had a homogeneous fine layer, while the fine soil of the second barrier was layered to increase its ability to laterally divert infiltrating moisture. The barriers were subjected first to constant infiltration while minimizing evaporative losses and then were exposed to ambient conditions. The continuous infiltration period of the field tests for the two barrier systems was modelled to determine the ability of an existing code to accurately represent capillary barrier behavior embodied in these two designs. Differences between the field test and the model data were found, but in general the simulations appeared to adequately reproduce the response of the test systems. Accounting for moisture retention hysteresis in the layered system will potentially lead to more accurate modelling results and is likely to be important when developing reasonable predictions of capillary barrier behavior.

  2. Numerical simulations of capillary barrier field tests

    International Nuclear Information System (INIS)

    Numerical simulations of two capillary barrier systems tested in the field were conducted to determine if an unsaturated flow model could accurately represent the observed results. The field data was collected from two 7-m long, 1.2-m thick capillary barriers built on a 10% grade that were being tested to investigate their ability to laterally divert water downslope. One system had a homogeneous fine layer, while the fine soil of the second barrier was layered to increase its ability to laterally divert infiltrating moisture. The barriers were subjected first to constant infiltration while minimizing evaporative losses and then were exposed to ambient conditions. The continuous infiltration period of the field tests for the two barrier systems was modelled to determine the ability of an existing code to accurately represent capillary barrier behavior embodied in these two designs. Differences between the field test and the model data were found, but in general the simulations appeared to adequately reproduce the response of the test systems. Accounting for moisture retention hysteresis in the layered system will potentially lead to more accurate modelling results and is likely to be important when developing reasonable predictions of capillary barrier behavior

  3. DESIGN AND CONTROL OF SOAP-FREE HYDROPHILIC-HYDROPHOBIC CORE-SHELL LATEX PARTICLES WITH HIGH CARBOXYL CONTENT IN THE CORE OF THE PARTICLES

    Institute of Scientific and Technical Information of China (English)

    Wen-jiao Ji; Yi-ming Jiang; Bo-tian Li; Wei Deng; Cheng-you Kan

    2012-01-01

    Soap-free hydrophilic-hydrophobic core-shell latex particles with high carboxyl content in the core of the particles were synthesized via the seeded emulsion polymerization using methyl methacrylate (MMA),butyl acrylate (BA),methacrylic acid (MAA),styrene (St) and ethylene glycol dimethacrylate (EGDMA) as monomers,and the influences of MMA content used in the core preparation on polymerization,particle size and morphology were investigated by transmission electron microscopy,dynamic light scattering and conductometric titration.The results showed that the seeded emulsion polymerization could be carried out smoothly using "starved monomer feeding process" when MAA content in the core preparation was equal to or less than 24 wt%,and the encapsulating efficiency of the hydrophilic P(MMA-BA-MAA-EGDMA) core with the hydrophobic PSt shell decreased with the increase in MAA content.When an interlayer of P(MMA-MAA-St) with moderate polarity was inserted between the P(MMA-BA-MAA-EGDMA) core and the PSt shell,well designed soap-free hydrophilic-hydrophobic core-shell latex particles with 24 wt% MAA content in the core preparation were obtained.

  4. Surgical reconstruction of maxillary defects using a computer-assisted design/computer-assisted manufacturing-produced titanium mesh supporting a free flap.

    Science.gov (United States)

    Tarsitano, Achille; Battaglia, Salvatore; Ciocca, Leonardo; Scotti, Roberto; Cipriani, Riccardo; Marchetti, Claudio

    2016-09-01

    The maxilla provides support to the overlying structures and contributes significantly to the overall facial appearance and to critical functions such as mastication, speech, and deglutition. Many different techniques have been used over the years to achieve this reconstructive goal. Modern computer-assisted surgery affords new methods for planning resections, as well as optimising reconstructive outcomes and functional rehabilitation. The aim of this study was to describe our experience with, and technique for, the functional, structural, and aesthetic reconstruction of maxillary bone defects using a computer-assisted design (CAD)/computer-assisted manufacturing (CAM)-printed titanium mesh to provide structural support for free flap reconstruction. Four patients who underwent reconstruction with a CAD/CAM-printed titanium mesh were included in this study. The preoperative computed tomography (CT) data set used for virtual planning was superimposed onto the postoperative CT scan to calculate the difference between the virtually planned position and the postoperative position of the titanium mesh. The orbital floor and alveolus were the most frequent sites of deviation, and good reproducibility could be obtained with less than 1 mm of deviation between planning and results in most regions. Printed titanium meshes obtained with CAD/CAM technology and used to structurally support free flaps provide a valuable method for the achievement of good aesthetic, structural, and functional outcomes in maxillary reconstruction. Reconstructive accuracy using this technique is reasonably high. Further studies with a larger number of patients would be useful to confirm these results. PMID:27519658

  5. Design and realization of reflective current barrier for high-brightness LED chips%高亮度LED芯片的反射型电流阻挡层设计与实现

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    基于光学传输理论矩阵,设计制作SiO2和Ti3O5交替生长的分布式布拉格反射(DBR)结构作为LED芯片的电流阻挡层,并采用电感耦合等离子体(ICP)刻蚀技术在电流阻挡层处形成沟槽结构,以解决困扰LED器件效率提高的电流扩散及金属电极降低出光效率的问题。实验结果表明,采用这种结构的LED芯片能将亮度提高5%以上,而LED芯片的正向电压基本维持不变。这种反射型电流阻挡层结构能够很好地改善大尺寸LED芯片的电流扩散,有效地提高LED芯片的出光效率。%Based on optical transfer matrix theory,a distributed Bragg reflector(DBR) consisting of SiO2 and Ti3O5 is designed as the current barrier layer for high-brightness LED chips,and a trench structure is etched by inductively coupled plasma(ICP) technique at the current barrier.The problems that the current spreading restricts the improvement of the LED efficiency and the metal electrodes reduce light-extraction efficiency are solved by this way.The experiment results indicate that the brightness of the LED chip with this structure can be increased by 5%,while the chip voltage is essentially unchanged,which shows that the new structure can greatly ameliorate the current spreading and increase the extraction efficiency of LED chip.

  6. Complementary barrier infrared detector (CBIRD)

    Science.gov (United States)

    Ting, David Z. (Inventor); Bandara, Sumith V. (Inventor); Hill, Cory J. (Inventor); Gunapala, Sarath D. (Inventor)

    2013-01-01

    An infrared detector having a hole barrier region adjacent to one side of an absorber region, an electron barrier region adjacent to the other side of the absorber region, and a semiconductor adjacent to the electron barrier.

  7. Surface Functionalization of g-C3 N4 : Molecular-Level Design of Noble-Metal-Free Hydrogen Evolution Photocatalysts.

    Science.gov (United States)

    Chen, Yin; Lin, Bin; Yu, Weili; Yang, Yong; Bashir, Shahid M; Wang, Hong; Takanabe, Kazuhiro; Idriss, Hicham; Basset, Jean-Marie

    2015-07-13

    A stable noble-metal-free hydrogen evolution photocatalyst based on graphite carbon nitride (g-C3 N4 ) was developed by a molecular-level design strategy. Surface functionalization was successfully conducted to introduce a single nickel active site onto the surface of the semiconducting g-C3 N4 . This catalyst family (with less than 0.1 wt % of Ni) has been found to produce hydrogen with a rate near to the value obtained by using 3 wt % platinum as co-catalyst. This new catalyst also exhibits very good stability under hydrogen evolution conditions, without any evidence of deactivation after 24 h. PMID:26073972

  8. Hydraulic analysis on effects of back-plate deformation upon stability of high-speed free-surface lithium flow for IFMIF target design

    International Nuclear Information System (INIS)

    For engineering design of liquid lithium (Li) target of the International Fusion Materials Irradiation Facility (IFMIF), two-dimensional hydraulic analysis was performed using code FLUENT. The analysis clarified effects of smooth deformation at the center of the back-plate part of the flow channel upon velocity and pressure in the high-speed free-surface Li flow. Convex deformations caused decrease in jet thickness and thus increase in velocity and decrease in pressure. Convex deformations caused vice versa. Acceptable limit of the back-plate deformation to avoid Li boiling in IFMIF target was 1.0 mm for the convex deformation and 3.0 mm for the concave deformation. Spatial range of the effects of the deformation was localized around deformation as far as no boiling.

  9. Design Features of a Planar Hybrid/Permanent Magnet Strong Focusing Undulator for Free Electron Laser (FEL) And Synchrotron Radiation (SR) Applications

    Energy Technology Data Exchange (ETDEWEB)

    Tatchyn, Roman; /SLAC

    2011-09-09

    Insertion devices for Angstrom-wavelength Free Electron Laser (FEL) amplifiers driven by multi-GeV electron beams generally require distributed focusing substantially stronger than their own natural focusing fields. Over the last several years a wide variety of focusing schemes and configurations have been proposed for undulators of this class, ranging from conventional current-driven quadrupoles external to the undulator magnets to permanent magnet (PM) lattices inserted into the insertion device gap. In this paper we present design studies of a flexible high-field hybrid/PM undulator with strong superimposed planar PM focusing proposed for a 1.5 Angstrom Linac Coherent Light Source (LCLS) driven by an electron beam with a 1 mm-mr normalized emittance. Attainable field parameters, tuning modes, and potential applications of the proposed structure are discussed.

  10. Surface Functionalization of g-C 3 N 4 : Molecular-Level Design of Noble-Metal-Free Hydrogen Evolution Photocatalysts

    KAUST Repository

    Chen, Yin

    2015-06-12

    A stable noble-metal-free hydrogen evolution photocatalyst based on graphite carbon nitride (g-C3N4) was developed by a molecular-level design strategy. Surface functionalization was successfully conducted to introduce a single nickel active site onto the surface of the semiconducting g-C3N4. This catalyst family (with less than 0.1 wt% of Ni) has been found to produce hydrogen with a rate near to the value obtained by using 3 wt% platinum as co-catalyst. This new catalyst also exhibits very good stability under hydrogen evolution conditions, without any evidence of deactivation after 24h. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Converse Barrier Certificate Theorem

    DEFF Research Database (Denmark)

    Wisniewski, Rafael; Sloth, Christoffer

    2013-01-01

    This paper presents a converse barrier certificate theorem for a generic dynamical system.We show that a barrier certificate exists for any safe dynamical system defined on a compact manifold. Other authors have developed a related result, by assuming that the dynamical system has no singular...... points in the considered subset of the state space. In this paper, we redefine the standard notion of safety to comply with generic dynamical systems with multiple singularities. Afterwards, we prove the converse barrier certificate theorem and illustrate the differences between ours and previous work by...

  12. Recycler barrier RF buckets

    CERN Document Server

    Bhat, C M

    2012-01-01

    The Recycler Ring at Fermilab uses a barrier rf system for all of its rf manipulations. In this paper, I will give an overview of historical perspective on barrier rf systems, the longitudinal beam dynamics issues, aspects of rf linearization to produce long flat bunches and methods used for emittance measurements of the beam in the RR barrier rf buckets. Current rf manipulation schemes used for antiproton beam stacking and longitudinal momentum mining of the RR beam for the Tevatron collider operation are explained along with their importance in spectacular success of the Tevatron luminosity performance.

  13. Recycler barrier RF buckets

    Energy Technology Data Exchange (ETDEWEB)

    Bhat, C.M.; /Fermilab

    2011-03-01

    The Recycler Ring at Fermilab uses a barrier rf systems for all of its rf manipulations. In this paper, I will give an overview of historical perspective on barrier rf system, the longitudinal beam dynamics issues, aspects of rf linearization to produce long flat bunches and methods used for emittance measurements of the beam in the RR barrier rf buckets. Current rf manipulation schemes used for antiproton beam stacking and longitudinal momentum mining of the RR beam for the Tevatron collider operation are explained along with their importance in spectacular success of the Tevatron luminosity performance.

  14. Structure Design and Optimization for Carbon Free Car of New Type%新型"无碳小车"的结构设计与优化

    Institute of Scientific and Technical Information of China (English)

    陈波; 兰健; 曹伟龙; 于奎东; 孙玉恒

    2015-01-01

    通过对现有无碳小车的评价与分析,在小车结构上进行了优化,力求在满足命题要求基础上,达到结构最简、车体最轻、好加工、易操作等特点. 文章主要从车身、能量转换机构、传动机构、转向机构、驱动机构等几方面入手,详细介绍了小车结构重新设计进一步优化的具体方案及工作原理. 实践结果表明,改进后的新型无碳小车整体性能有了很大提高,无论是行走距离,还是绕障数量都有了明显的增加. 该设计优化对实训教学具有一定的指导意义.%By evaluation and analysis to existing carbon free car, the car structure is optimized in order to achieve characteristics, such as simplest structure、lightest body、good manufacturability and operability etc. on the condition that the proposition requirement is met. Starting from car body,energy transformation mechanism, transmission mechanism,steering mechanism and drive mechanism etc., this paper details the further optimized project and working principle for car structure re-design. Practice result shows that the overall performance of carbon free car was greatly improved after optimization, no matter in driving distance or bypassing obstacle. And this design optimization means guiding significance to practical training.

  15. Membrane barriers for radon gas flow restrictions

    International Nuclear Information System (INIS)

    Research was performed to assess the feasibility of barrier membrane substances, for use within mining or associated high risk environments, in restricting the diffusion transport of radon gas quantities. Specific tests were conducted to determine permeability parameters of a variety of membrane materials with reference to radon flow capabilities. Tests were conducted both within laboratory and in-situ emanation environments where concentrations and diffusion flows of radon gas were known to exist. Equilibrium radon gas concentrations were monitored in initially radon-free chambers adjacent to gas sources, but separated by specified membrane substances. Membrane barrier effectiveness was demonstrated to result in reduced emanation concentrations of radon gas within the sampling chamber atmosphere. Minimum gas concentrations were evidenced where the barrier membrane material was shown to exhibit lowest radon permeability characteristics

  16. Focused feasibility study of engineered barriers for waste management units in the 200 areas

    International Nuclear Information System (INIS)

    This Focused Feasibility Study (FFS) evaluates a total of four conceptual barrier designs for different types of waste sites. The Hanford Barrier, the Modified RCRA Subtitle C Barrier, and the Modified RCRA Subtitle D Barrier are being considered as the baseline design for the purpose of the FFS evaluation. A fourth barrier design, the Standard RCRA Subtitle C Barrier, is also evaluated in this FFS; it is commonly applied at other waste sites across the country. These four designs provide a range of cover options to minimize health and environmental risks associated with a site and specific waste categories for active design life periods of 30, 100, 500, and 1,000 years. Design criteria for the 500 and 1,000-year design life barriers include design performance to extend beyond active institutional control and monitoring periods

  17. Evaluation of Erosion Resistance of Advanced Turbine Thermal Barrier Coatings

    Science.gov (United States)

    Zhu, Dongming; Kuczmarski, Maria A.; Miller, Robert A.; Cuy, Michael D.

    2007-01-01

    The erosion resistant turbine thermal barrier coating system is critical to aircraft engine performance and durability. By demonstrating advanced turbine material testing capabilities, we will be able to facilitate the critical turbine coating and subcomponent development and help establish advanced erosion-resistant turbine airfoil thermal barrier coatings design tools. The objective of this work is to determine erosion resistance of advanced thermal barrier coating systems under simulated engine erosion and/or thermal gradient environments, validating advanced turbine airfoil thermal barrier coating systems based on nano-tetragonal phase toughening design approaches.

  18. [Vascular endothelial Barrier Function].

    Science.gov (United States)

    Ivanov, A N; Puchinyan, D M; Norkin, I A

    2015-01-01

    Endothelium is an important regulator of selective permeability of the vascular wall for different molecules and cells. This review summarizes current data on endothelial barrier function. Endothelial glycocalyx structure, its function and role in the molecular transport and leukocytes migration across the endothelial barrier are discussed. The mechanisms of transcellular transport of macromolecules and cell migration through endothelial cells are reviewed. Special section of this article addresses the structure and function of tight and adherens endothelial junction, as well as their importance for the regulation of paracellular transport across the endothelial barrier. Particular attention is paid to the signaling mechanism of endothelial barrier function regulation and the factors that influence on the vascular permeability.

  19. Barriers to Effective Listening.

    Science.gov (United States)

    Hulbert, Jack E.

    1989-01-01

    Discusses the following barriers which interfere with listening efficiency: content, speaker, medium, distractions, mindset, language, listening speed, and feedback. Suggests ways to combat these obstacles to accurate comprehension. (MM)

  20. Overcoming Intercultural Communication Barriers.

    Science.gov (United States)

    Hulbert, Jack E.

    1994-01-01

    Describes an activity that helps students overcome the multicultural barriers that might be encountered in dealing with people from various cultures in a global economy. Outlines instructions, reporting procedures, principles to emphasize, and time required for the exercise. (HB)

  1. Information barriers and authentication

    International Nuclear Information System (INIS)

    Acceptance of nuclear materials into a monitoring regime is complicated if the materials are in classified shapes or have classified composition. An attribute measurement system with an information barrier can be emplo,yed to generate an unclassified display from classified measurements. This information barrier must meet two criteria: (1) classified information cannot be released to the monitoring party, and (2) the monitoring party must be convinced that the unclassified output accurately represents the classified input. Criterion 1 is critical to the host country to protect the classified information. Criterion 2 is critical to the monitoring party and is often termed the 'authentication problem.' Thus, the necessity for authentication of a measurement system with an information barrier stems directly from the description of a useful information barrier. Authentication issues must be continually addressed during the entire development lifecycle of the measurement system as opposed to being applied only after the system is built.

  2. Polarizability of the active site of cytochrome c reduces the activation barrier for electron transfer

    Science.gov (United States)

    Dinpajooh, Mohammadhasan; Martin, Daniel R.; Matyushov, Dmitry V.

    2016-06-01

    Enzymes in biology’s energy chains operate with low energy input distributed through multiple electron transfer steps between protein active sites. The general challenge of biological design is how to lower the activation barrier without sacrificing a large negative reaction free energy. We show that this goal is achieved through a large polarizability of the active site. It is polarized by allowing a large number of excited states, which are populated quantum mechanically by electrostatic fluctuations of the protein and hydration water shells. This perspective is achieved by extensive mixed quantum mechanical/molecular dynamics simulations of the half reaction of reduction of cytochrome c. The barrier for electron transfer is consistently lowered by increasing the number of excited states included in the Hamiltonian of the active site diagonalized along the classical trajectory. We suggest that molecular polarizability, in addition to much studied electrostatics of permanent charges, is a key parameter to consider in order to understand how enzymes work.

  3. Cold-air performance of free power turbine designed for 112-kilowatt automotive gas-turbine engine 3: Effect of stator vane end clearances on performance

    Science.gov (United States)

    Kofskey, M. G.; Mclallin, K. L.

    1978-01-01

    An experimental investigation of a free power turbine designed for a 112-kW, automotive, gas turbine engine was made to determine the penalty in performance due to the stator vane end clearances. Tests were made over a range of mean section stator vane angles from 26 deg to 50 deg (as measured from the plane of rotation) with the vane end clearances filled. These results were compared with test results of the same turbine with vane end clearances open. At design equivalent values of rotative speed and pressure ratio and at a vane angle of 35 deg, the mass flow with the vane and clearances filled was about 8 percent lower than mass flow with vane end clearances open. The decrease in mass flow was mitigated by increasing the vane angle. With the vane end clearances filled, there was about a 66 percent reduction in mass flow when the vane angle was decreased from 40 deg to 26 deg. For the same decrease in vane angle the stator throat area decreased by about 50 percent. This result indicates that the rotor losses were increasing with decreasing vane angle.

  4. Design and fabrication of ripple-free CMOS-compatible stacked membranes for airgap optical filters for UV-visible spectrum

    Science.gov (United States)

    Ghaderi, Mohammadamir; de Graaf, Ger; Wolffenbuttel, Reinoud F.

    2016-04-01

    CMOS-compatible fabrication of thin dielectric membranes for the ultraviolet and visible spectrum is presented for use in airgap/SiO2-based interference filter design. A typical optical design consists of multiple membranes of 50-100 nm thickness. Maintaining flatness over a large area, as required by the optical application, is challenging. In such a free-standing membrane, the residual stress is the main force acting on the structure. Although an overall tensile residual stress can effectively stretch the membrane, too much stress would exceed the yield strength of the material and results in fracturing. Furthermore, the presence of a residual stress gradient causes the membrane to deform. In this work, the effect of a stress profile in the thin film has is investigated. Although PECVD SiO2 layers with an average tensile stress level of 178 MPa are used for the fabrication of the membranes, the presence of a stress gradient of about 0:67 MPa=nm results in a deformation in the membrane. A simple straining method is applied to reduce flatness. The preliminary results and discusses the challenges in the fabrication of stacked membranes for optical filters are presented.

  5. Waterproofing with polymeric geo synthetic barriers (GBR-P) in the manual for the design, construction, management and maintenance of reservoirs; La impermeabilizacion con barreras geosinteticas polimericas (GBR-P) en el manual para el diseno, construccion, explotacion y mantenimiento de balsas

    Energy Technology Data Exchange (ETDEWEB)

    Blanco, M.; Cea, J. C.; Garcia, F.; Sanchez, F. J.; Castillo, F.; Mora, J.; Crespo, M. A.

    2010-07-01

    This article presents a part of Manual for the Design, Construction, Management and Maintenance of Reservoirs relative to waterproofing with Polymeric Geo synthetic Barriers (GBR-P). the nature materials of geo membranes is studied also theirs characteristics and specifications. (Author) 26 refs.

  6. Epistemonikos: a free, relational, collaborative, multilingual database of health evidence.

    Science.gov (United States)

    Rada, Gabriel; Pérez, Daniel; Capurro, Daniel

    2013-01-01

    Epistemonikos (www.epistemonikos.org) is a free, multilingual database of the best available health evidence. This paper describes the design, development and implementation of the Epistemonikos project. Using several web technologies to store systematic reviews, their included articles, overviews of reviews and structured summaries, Epistemonikos is able to provide a simple and powerful search tool to access health evidence for sound decision making. Currently, Epistemonikos stores more than 115,000 unique documents and more than 100,000 relationships between documents. In addition, since its database is translated into 9 different languages, Epistemonikos ensures that non-English speaking decision-makers can access the best available evidence without language barriers.

  7. Free Radicals and Matrix Metalloproteinases in Blood-Brain Barrier Disruption after Cerebral Ischemia%自由基和基质金属蛋白酶介导脑缺血血脑屏障损伤的研究进展

    Institute of Scientific and Technical Information of China (English)

    戚智锋; 罗玉敏; 刘克建

    2012-01-01

    血脑屏障的破坏是引起脑缺血损伤及继发水肿、出血、炎症的微观原因.缺血缺氧和再灌注过程产生的自由基,以及后续基质金属蛋白酶的激活,是破坏血脑屏障结构和功能的重要分子机制.因而,在脑缺血早期及时抑制自由基产生并清除自由基,抑制基质金属蛋白酶的活性,是降低脑缺血血脑屏障损伤及其并发症的关键环节.本文将从血脑屏障损伤的角度,概述自由基与基质金属蛋白酶在脑缺血损伤过程中的作用.%Cerebral ischemia results in the compromise of blood-brain barrier (BBB) integrity, leading to neurovascular complications, including cerebral hemorrhage, edema, and inflammation. Free radicals and matrix metalloproteinases (MMPs) are critically involved in the mechanism of BBB breakdown following cerebral ischemia and reperfusion. Scavenging free radicals and inhibiting activation of MMPs are potential strategies to protect BBB integrity and reduce ischemia complications. In this review, we will focus on the the role of free radicals and MMPs activation in BBB damages in cerebral ischemia.

  8. Is cost a structural barrier preventing men who have sex with men accessing condoms? A systematic review.

    Science.gov (United States)

    Ubrihien, Ashley; Davies, Stephen C; Driscoll, Tim

    2016-11-01

    A systematic review was undertaken to determine whether cost is a structural barrier preventing men who have sex with men (MSM) accessing condoms. Studies were examined from a range of countries where condoms have been distributed free to particular populations and also those where condoms were available at a cost to the individual. The study inclusion criteria were: published between January 1990 and September 2014 inclusive; published in any language, discussed cost as a barrier to condom use, discussed cost barriers to MSM accessing condoms and included a measure of outcome. Articles were systematically extracted from MEDLINE, Embase, PyschINFO and Informat using the five search terms; Male Homosexuality, Access, Cost, Cost and Cost analysis, Condoms. Sixty-four articles were initially identified and 11 included in the final review. The included studies used cost-utility analysis, qualitative, cross-sectional, cohort or randomised control trial design. Large-scale free distribution programmes and smaller targeted programmes showed positive correlations in reducing the burden of disease from HIV and other sexually transmitted infections through eliminating the issue of cost. Decreasing the cost of condoms, and providing them for no cost, appears to increase their utilisation amongst MSM and possibly reduce the burden from HIV and other sexually transmitted infections. Inequality and stigma remain important barriers to MSM accessing and using condoms particularly in the developing world. PMID:27240970

  9. Biointrusion test plan for the Permanent Isolation Surface Barrier Prototype

    International Nuclear Information System (INIS)

    This document provides a testing and monitoring plan for the biological component of the prototype barrier slated for construction at the Hanford Site. The prototype barrier is an aboveground structure engineered to demonstrate the basic features of an earthen cover system. It is designed to permanently isolate waste from the biosphere. The features of the barrier include multiple layers of soil and rock materials and a low-permeability asphalt sublayer. The surface of the barrier consists of silt loam soil, covered with plants. The barrier sides are reinforced with rock or coarse earthen-fill to protect against wind and water erosion. The sublayers inhibit plant and animal intrusion and percolation of water. A series of tests will be conducted on the prototype barrier over the next several years to evaluate barrier performance under extreme climatic conditions. Plants and animals will play a significant role in the hydrologic and water and wind erosion characteristics of the prototype barrier. Studies on the biological component of the prototype barrier will include work on the initial revegetation of the surface, continued monitoring of the developing plant community, rooting depth and dispersion in the context of biointrusion potential, the role of plants in the hydrology of the surface and toe regions of the barrier, the role of plants in stabilizing the surface against water and wind erosion, and the role of burrowing animals in the hydrology and water and wind erosion of the barrier

  10. Model assessment of protective barriers: Part 3

    Energy Technology Data Exchange (ETDEWEB)

    Fayer, M.J.; Rockhold, M.L.; Holford, D.J.

    1992-02-01

    Radioactive waste exists at the US Department of Energy's (DOE's) Hanford Site in a variety of locations, including subsurface grout and tank farms, solid waste burial grounds, and contaminated soil sites. Some of these waste sites may need to be isolated from percolating water to minimize the potential for transport of the waste to the ground water, which eventually discharges to the Columbia River. Multilayer protective barriers have been proposed as a means of limiting the flow of water through the waste sites (DOE 1987). A multiyear research program (managed jointly by Pacific Northwest Laboratory (PNL) and Westinghouse Hanford Company for the DOE) is aimed at assessing the performance of these barriers. One aspect of this program involves the use of computer models to predict barrier performance. Three modeling studies have already been conducted and a test plan was produced. The simulation work reported here was conducted by PNL and extends the previous modeling work. The purpose of this report are to understand phenomena that have been observed in the field and to provide information that can be used to improve hydrologic modeling of the protective barrier. An improved modeling capability results in better estimates of barrier performance. Better estimates can be used to improve the design of barriers and the assessment of their long-term performance.

  11. Design, dynamics and control of an Adaptive Singularity-Free Control Moment Gyroscope actuator for microspacecraft Attitude Determination and Control System

    Science.gov (United States)

    Viswanathan, Sasi Prabhakaran

    Design, dynamics, control and implementation of a novel spacecraft attitude control actuator called the "Adaptive Singularity-free Control Moment Gyroscope" (ASCMG) is presented in this dissertation. In order to construct a comprehensive attitude dynamics model of a spacecraft with internal actuators, the dynamics of a spacecraft with an ASCMG, is obtained in the framework of geometric mechanics using the principles of variational mechanics. The resulting dynamics is general and complete model, as it relaxes the simplifying assumptions made in prior literature on Control Moment Gyroscopes (CMGs) and it also addresses the adaptive parameters in the dynamics formulation. The simplifying assumptions include perfect axisymmetry of the rotor and gimbal structures, perfect alignment of the centers of mass of the gimbal and the rotor etc. These set of simplifying assumptions imposed on the design and dynamics of CMGs leads to adverse effects on their performance and results in high manufacturing cost. The dynamics so obtained shows the complex nonlinear coupling between the internal degrees of freedom associated with an ASCMG and the spacecraft bus's attitude motion. By default, the general ASCMG cluster can function as a Variable Speed Control Moment Gyroscope, and reduced to function in CMG mode by spinning the rotor at constant speed, and it is shown that even when operated in CMG mode, the cluster can be free from kinematic singularities. This dynamics model is then extended to include the effects of multiple ASCMGs placed in the spacecraft bus, and sufficient conditions for non-singular ASCMG cluster configurations are obtained to operate the cluster both in VSCMG and CMG modes. The general dynamics model of the ASCMG is then reduced to that of conventional VSCMGs and CMGs by imposing the standard set of simplifying assumptions used in prior literature. The adverse effects of the simplifying assumptions that lead to the complexities in conventional CMG design, and

  12. Evaluation of swimming capability and potential velocity barrier problems for fish. Part A: Swimming performance of selected warm and cold water fish species relative to fish passage and fishway design

    International Nuclear Information System (INIS)

    The objective of this study was to provide information about the swimming capability of several widely distributed, economically or recreationally important fish species, for use in mitigating potential velocity barrier problems associated with hydroelectric power facilities. Swimming capability of anadromous and landlocked Atlantic salmon, brook trout, brown trout, lake sturgeon, and walleye, collected from various locations throughout Canada, were investigated to develop criteria for sustained, prolonged, burst swimming performance characteristics of the study species, fish physiology, life history and migration distance on swimming performance. Swimming performance characteristics in the wild, especially the use of physiological telemetry, as well as development of new methodology for the measurement of burst speed was also central to the study. Models were derived to describe swimming capabilities for each study species/life stage in relation to fish length, water velocity, water temperature, and other significant environmental factors. The data will form the basis of guideline development and decision making to improve design and evaluation of fish passage facilities. A series of annotated bibliographies resulting from the study are described in Appendix B. 74 refs., 8 tabs., figs., 2 appendices

  13. Identifying barriers to billing compliance.

    Science.gov (United States)

    Lorence, Daniel P; Ibrahim, Ibrahim Awad

    2003-01-01

    Programs designed toward the control of health care fraud are leading to increasingly aggressive enforcement and prosecutorial efforts by federal regulators, related to over-reimbursement for service providers. Greater penalties for fraudulent practices have been touted as an effective deterrent to practices that encourage, or fail to prevent, incorrect claims for reimbursement. In such a context, this study sought to examine the extent of compliance management barriers through a national survey of all accredited US health information managers, examining likely barriers to payment of health care claims. Using data from a series of surveys on the stated compliance actions of more than 16,000 health care managers, we find that the publication and dissemination of compliance enforcement regulations had a significant effect on the reduction of fraud. Results further suggest that significant non-adoption of proper billing compliance measures continues to occur, despite the existence of counter-fraud prosecution risk designed to enforce proper compliance. Finally, we identify benchmarks of compliance management and show how they vary across demographic, practice setting, and market characteristics. We find significant variation in influence across practice settings and managed care markets. While greater publicity related to proper billing procedures generally leads to greater compliance awareness, this trend may have created pockets of "institutional non-compliance," which result in an increase in the prevalence of non-compliant management actions. As a more general proposition, we find that it is not sufficient to consider compliance actions independent of institutional or industry-wide influences. PMID:12967244

  14. Protection against malevolent use of vehicles at Nuclear Power Plants. Vehicle barrier system selection guidance

    International Nuclear Information System (INIS)

    This manual provides a simplified procedure for selecting land vehicle barriers that will stop the design basis vehicle threat adopted by the U.S. Nuclear Regulatory Commission. Proper selection and construction of vehicle barriers should prevent intrusion of the design basis vehicle. In addition, vital safety related equipment should survive a design basis vehicle bomb attack when vehicle barriers are properly selected, sited, and constructed. This manual addresses passive vehicle barriers, active vehicle barriers, and site design features that can be used to reduce vehicle impact velocity

  15. An insight into the performance of road barriers - redistribution of barrier-relevant crashes.

    Science.gov (United States)

    Zou, Yaotian; Tarko, Andrew P

    2016-11-01

    Unlike most of traffic safety treatments that prevent crashes, road barriers reduce the severity of crash outcomes by replacing crashes with a high risk of severe injury and fatality (such as median crossover head-on collisions or collisions with high-hazard objects) with less risky events (such as collisions with barriers). This "crash conversion" is actually more complex than one-to-one replacement and it has not been studied yet. The published work estimated the reduction of selected types of crashes (typically, median crossover collisions) or the overall effect of barriers on crash severity. The objective of this study was to study the probabilities of various types of crash events possible under various road and barrier scenarios. The estimated probabilities are conditional given that at least one vehicle left the travelled way and the resulted crash had been recorded. The results are meant to deliver a useful insight onto the conversion of crashes by barriers from more to less risky to help better understand the mechanism of crash severity reduction. Such knowledge should allow engineers more accurate estimation of barriers' benefits and help researchers evaluate barriers' performance to improve the barrier's design. Seven barrier-relevant crash events possible after a vehicle departs the road could be identified based on the existing crash data and their probabilities estimated given the presence and location of three types of barriers: median concrete barriers, median and roadside W-beam steel guardrails, and high-tension median cable barriers. A multinomial logit model with variable outcomes was estimated based on 2049 barrier-relevant crashes occurred between 2003 and 2012 on 1258 unidirectional travelled ways in Indiana. The developed model allows calculating the changes in the probabilities of the barrier-relevant crash events. The results of this study indicated that road departures lead to less frequent crossings of unprotected (no barriers) medians

  16. Method of installing subsurface barrier

    Science.gov (United States)

    Nickelson, Reva A.; Richardson, John G.; Kostelnik, Kevin M.; Sloan, Paul A.

    2007-10-09

    Systems, components, and methods relating to subterranean containment barriers. Laterally adjacent tubular casings having male interlock structures and multiple female interlock structures defining recesses for receiving a male interlock structure are used to create subterranean barriers for containing and treating buried waste and its effluents. The multiple female interlock structures enable the barriers to be varied around subsurface objects and to form barrier sidewalls. The barrier may be used for treating and monitoring a zone of interest.

  17. Skin barrier in rosacea.

    Science.gov (United States)

    Addor, Flavia Alvim Sant'Anna

    2016-01-01

    Recent studies about the cutaneous barrier demonstrated consistent evidence that the stratum corneum is a metabolically active structure and also has adaptive functions, may play a regulatory role in the inflammatory response with activation of keratinocytes, angiogenesis and fibroplasia, whose intensity depends primarily on the intensity the stimulus. There are few studies investigating the abnormalities of the skin barrier in rosacea, but the existing data already show that there are changes resulting from inflammation, which can generate a vicious circle caused a prolongation of flare-ups and worsening of symptoms. This article aims to gather the most relevant literature data about the characteristics and effects of the state of the skin barrier in rosacea. PMID:26982780

  18. Tacit Knowledge Barriers in Franchising: Practical Solutions

    Science.gov (United States)

    Cumberland, Denise; Githens, Rod

    2012-01-01

    Purpose: The purpose of this paper is to identify barriers that hinder tacit knowledge transfer in a franchise environment and offer a compendium of solutions that encourage franchisees and franchisors to leverage tacit knowledge as a resource for competitive advantage. Design/methodology/approach: Drawing from the research on franchise…

  19. 针对FreeBSD的网络灾难备份系统设计与实现%Design and implementation of disaster recovery system based on FreeBSD

    Institute of Scientific and Technical Information of China (English)

    李响; 刘晓洁; 李涛; 吴波; 答治茜; 李海林; 沙金川

    2007-01-01

    探讨了灾难备份与FreeBSD操作系统联合使用的重要性,并提出和实现了一种针对FreeBSD的容灾平台.该平台能够提供磁盘高速镜像、磁盘监控和集系统恢复于一体的容灾系统.

  20. Thermal fission rates with temperature dependent fission barriers

    CERN Document Server

    Zhu, Yi

    2016-01-01

    \\item[Background] The fission processes of thermal excited nuclei are conventionally studied by statistical models which rely on inputs of phenomenological level densities and potential barriers. Therefore the microscopic descriptions of spontaneous fission and induced fission are very desirable for a unified understanding of various fission processes. \\item[Purpose] We propose to study the fission rates, at both low and high temperatures, with microscopically calculated temperature-dependent fission barriers and mass parameters. \\item[Methods] The fission barriers are calculated by the finite-temperature Skyrme-Hartree-Fock+BCS method. The mass parameters are calculated by the temperature-dependent cranking approximation. The thermal fission rates can be obtained by the imaginary free energy approach at all temperatures, in which fission barriers are naturally temperature dependent. The fission at low temperatures can be described mainly as a barrier-tunneling process. While the fission at high temperatures ...

  1. Hanford prototype-barrier status report: FY 1995

    Energy Technology Data Exchange (ETDEWEB)

    Gee, G.W.; Ward, A.L.; Gilmore, B.G.; Ligotke, M.W.; Link, S.O.

    1995-11-01

    Surface barriers (or covers) have been proposed for use at the Hanford Site as a means to isolate certain waste sites that, for reasons of cost or worker safety or both, may not be exhumed. Surface barriers are intende to isolated the wastes from the accessible environment and to provide long-term protection to future populations that might use the Hanford Site. Currently, no ``proven`` long-term barrier system is available. For this reason, the Hanford Site Permanent Isolation Surface-Barrier Development Program (BDP) was organized to develop the technology needed to provide long-term surface barrier capability for the Hanford Site for the US Department of Energy (DOE). Designs have been proposed to meet the most stringent needs for long-term waste disposal. The objective of the current barrier design is to use natural materials to develop a protective barrier system that isolates wastes for at least 1000 years by limiting water, plant, animal, and human intrusion; and minimizing erosion. The design criteria for water drainage has been set at 0.5 mm/yr. While other design criteria are more qualitative, it is clear that waste isolation for an extended time is the prime objective of the design. Constructibility and performance. are issues that can be tested and dealt with by evaluating prototype designs prior to extensive construction and deployment of covers for waste sites at Hanford.

  2. Design Principles and Future Development of Metal-free Organic Dyes%非金属纯有机染料的设计规律和展望

    Institute of Scientific and Technical Information of China (English)

    杨秀云; 周杰; 王宇鹏; 高秀霞

    2011-01-01

    由于染料敏化太阳能电池(DSSC)由于成本低和光电转化效率高而引起诸多学者的兴趣.目前纯有机染料分子的合成已经受到特别的关注.本文主要针对染料敏化太阳能电池中染料分子设计方面展开论述,介绍了DSSC的组成、原理、设计理念以及对未来的展望.%Dye-sensitized solar cells (DSSC) have attracted considerable attention in recent years as they offer the possibility of low-cost and light-to-electricity conversion efficiency. Special attention has been paid to the synthesis of these pure organic dyes. This Review focuses on recent advances in molecular design of metal-free organic dyes. The basic construction and the photovoltaic principles of DSSC are introduced. In addition, the prospects of the DSSC are also summarized.

  3. The BTFEL, an infrared free-electron laser amplifier based on a new-design short-period superconducting tape undulator

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, M., E-mail: moohyun@postech.edu [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Department of Physics, Postech, Hyoja-dong, Pohang, Gyeongbuk 790-784 (Korea, Republic of); Filippetto, D.; Papadopoulos, C.F. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Pellegrini, C. [Department of Physics, University of California, Los Angeles, CA 90095 (United States); Penn, G.; Prestemon, S. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Sannibale, F., E-mail: fsannibale@lbl.gov [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States)

    2011-12-21

    The development of undulator technologies capable of generating sub-cm undulator periods is assuming an increasing importance in X-ray free electron laser (FEL) applications. Indeed, such devices jointly with the high brightness electron beams already demonstrated at operating facilities would allow for lower energy, more compact electron linacs with a beneficial impact on the size and cost of X-ray FEL facilities. A novel design super-conducting undulator is being developed at the Lawrence Berkeley National Laboratory (LBNL) with the potential of sub-cm periods with reasonably large undulator parameter and gap. The potential and capability of such undulator technology need to be experimentally demonstrated. In this paper, the possibility of constructing an infrared FEL by combining the new undulator with the high brightness beam from the APEX injector facility at LBNL is investigated. Calculations show that the resulting FEL, when operated in self-amplified-spontaneous-emission mode, is expected to deliver a saturated power of almost a MW within a {approx}4m undulator length, in a single-spike of coherent radiation at {approx}2{mu}m wavelength. It will be also shown that the small-period of the undulator associated with the relatively low energy of the APEX beam, forces the FEL to operate in a regime with unusual and interesting characteristics. The alternative option of laser seeding the FEL is also briefly examined, showing the potential to reduce the saturation length even further.

  4. Barriers in Quantum Gravity

    OpenAIRE

    Ambjorn, Jan

    1994-01-01

    I discuss recent progress in our understanding of two barriers in quantum gravity: $c > 1$ in the case of 2d quantum gravity and $D > 2$ in the case of Euclidean Einstein-Hilbert gravity formulated in space-time dimensions $D >2$.

  5. Breaking Down Barriers.

    Science.gov (United States)

    Watkins, Beverly T.

    1994-01-01

    Faculty at 11 higher education institutions in California, New Mexico, Texas, and northern Mexico have been experimenting with computer conferencing on the BESTNET (Bilingual English-Spanish Telecommunications Network). The growing system is credited with creating an international student-faculty community that crosses cultural barriers for…

  6. Homoepitaxial graphene tunnel barriers for spin transport

    Science.gov (United States)

    Friedman, Adam L.; van't Erve, Olaf M. J.; Robinson, Jeremy T.; Whitener, Keith E.; Jonker, Berend T.

    2016-05-01

    Tunnel barriers are key elements for both charge-and spin-based electronics, offering devices with reduced power consumption and new paradigms for information processing. Such devices require mating dissimilar materials, raising issues of heteroepitaxy, interface stability, and electronic states that severely complicate fabrication and compromise performance. Graphene is the perfect tunnel barrier. It is an insulator out-of-plane, possesses a defect-free, linear habit, and is impervious to interdiffusion. Nonetheless, true tunneling between two stacked graphene layers is not possible in environmental conditions usable for electronics applications. However, two stacked graphene layers can be decoupled using chemical functionalization. Here, we demonstrate that hydrogenation or fluorination of graphene can be used to create a tunnel barrier. We demonstrate successful tunneling by measuring non-linear IV curves and a weakly temperature dependent zero-bias resistance. We demonstrate lateral transport of spin currents in non-local spin-valve structures, and determine spin lifetimes with the non-local Hanle effect. We compare the results for hydrogenated and fluorinated tunnel and we discuss the possibility that ferromagnetic moments in the hydrogenated graphene tunnel barrier affect the spin transport of our devices.

  7. Geophysical characterization of subsurface barriers

    Energy Technology Data Exchange (ETDEWEB)

    Borns, D.J.

    1995-08-01

    An option for controlling contaminant migration from plumes and buried waste sites is to construct a subsurface barrier of a low-permeability material. The successful application of subsurface barriers requires processes to verify the emplacement and effectiveness of barrier and to monitor the performance of a barrier after emplacement. Non destructive and remote sensing techniques, such as geophysical methods, are possible technologies to address these needs. The changes in mechanical, hydrologic and chemical properties associated with the emplacement of an engineered barrier will affect geophysical properties such a seismic velocity, electrical conductivity, and dielectric constant. Also, the barrier, once emplaced and interacting with the in situ geologic system, may affect the paths along which electrical current flows in the subsurface. These changes in properties and processes facilitate the detection and monitoring of the barrier. The approaches to characterizing and monitoring engineered barriers can be divided between (1) methods that directly image the barrier using the contrasts in physical properties between the barrier and the host soil or rock and (2) methods that reflect flow processes around or through the barrier. For example, seismic methods that delineate the changes in density and stiffness associated with the barrier represents a direct imaging method. Electrical self potential methods and flow probes based on heat flow methods represent techniques that can delineate the flow path or flow processes around and through a barrier.

  8. Geophysical characterization of subsurface barriers

    International Nuclear Information System (INIS)

    An option for controlling contaminant migration from plumes and buried waste sites is to construct a subsurface barrier of a low-permeability material. The successful application of subsurface barriers requires processes to verify the emplacement and effectiveness of barrier and to monitor the performance of a barrier after emplacement. Non destructive and remote sensing techniques, such as geophysical methods, are possible technologies to address these needs. The changes in mechanical, hydrologic and chemical properties associated with the emplacement of an engineered barrier will affect geophysical properties such a seismic velocity, electrical conductivity, and dielectric constant. Also, the barrier, once emplaced and interacting with the in situ geologic system, may affect the paths along which electrical current flows in the subsurface. These changes in properties and processes facilitate the detection and monitoring of the barrier. The approaches to characterizing and monitoring engineered barriers can be divided between (1) methods that directly image the barrier using the contrasts in physical properties between the barrier and the host soil or rock and (2) methods that reflect flow processes around or through the barrier. For example, seismic methods that delineate the changes in density and stiffness associated with the barrier represents a direct imaging method. Electrical self potential methods and flow probes based on heat flow methods represent techniques that can delineate the flow path or flow processes around and through a barrier

  9. Phonon tunneling through a double barrier system

    Energy Technology Data Exchange (ETDEWEB)

    Villegas, Diosdado [Departamento de Física, Universidad Central “Marta Abreu” de Las Villas, CP 54830, Santa Clara, Villa Clara (Cuba); Instituto de Física, Universidad Autónoma de Puebla, 18 Sur y San Claudio, Edif. 110A, Ciudad Universitaria, 72570 Puebla (Mexico); León-Pérez, Fernando de [Centro Universitario de la Defensa de Zaragoza, Ctra. de Huesca s/n, E-50090 Zaragoza (Spain); Pérez-Álvarez, R. [Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, CP 62209 Cuernavaca (Mexico); Arriaga, J., E-mail: arriaga@ifuap.buap.mx [Instituto de Física, Universidad Autónoma de Puebla, 18 Sur y San Claudio, Edif. 110A, Ciudad Universitaria, 72570 Puebla (Mexico)

    2015-04-15

    The tunneling of optical and acoustic phonons at normal incidence on a double-barrier is studied in this paper. Transmission coefficients and resonance conditions are derived theoretically under the assumption that the long-wavelength approximation is valid. It is shown that the behavior of the transmission coefficients for the symmetric double barrier has a Lorentzian form close to resonant frequencies and that Breit–Wigner's formula have a general validity in one-dimensional phonon tunneling. Authors also study the so-called generalized Hartman effect in the tunneling of long-wavelength phonons and show that this effect is a numerical artifact resulting from taking the opaque limit before exploring the variation with a finite barrier width. This study could be useful for the design of acoustic devices.

  10. Surface barrier research at the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Gee, G.W.; Ward, A.L.; Fayer, M.J. [Pacific Northwest National Lab., Richland, WA (United States)

    1997-12-31

    At the DOE Hanford Site, a field-scale prototype surface barrier was constructed in 1994 over an existing waste site as a part of a CERCLA treatability test. The above-grade barrier consists of a fine-soil layer overlying coarse layers of sands, gravels, basalt rock (riprap), and a low permeability asphalt layer. Two sideslope configurations, clean-fill gravel on a 10:1 slope and basalt riprap on a 2:1 slope, were built and are being tested. Design considerations included: constructability; drainage and water balance monitoring, wind and water erosion control and monitoring; surface revegetation and biotic intrusion; subsidence and sideslope stability, and durability of the asphalt layer. The barrier is currently in the final year of a three-year test designed to answer specific questions related to stability and long-term performance. One half of the barrier is irrigated such that the total water applied, including precipitation, is 480 mm/yr (three times the long-term annual average). Each year for the past two years, an extreme precipitation event (71 mm in 8 hr) representing a 1,000-yr return storm was applied in late March, when soil water storage was at a maximum. While the protective sideslopes have drained significant amounts of water, the soil cover (2-m of silt-loam soil overlying coarse sand and rock) has never drained. During the past year there was no measurable surface runoff or wind erosion. This is attributed to extensive revegetation of the surface. In addition, the barrier elevation has shown a small increase of 2 to 3 cm that is attributed to a combination of root proliferation and freeze/thaw activity. Testing will continue through September 1997. Performance data from the prototype barrier will be used by DOE in site-closure decisions at Hanford.

  11. Vertical barriers with increased sorption capacities

    Energy Technology Data Exchange (ETDEWEB)

    Bradl, H.B. [Bilfinger + Berger Bauaktiengesellschaft, Mannheim (Germany)

    1997-12-31

    Vertical barriers are commonly used for the containment of contaminated areas. Due to the very small permeability of the barrier material which is usually in the order of magnitude of 10-10 m/s or less the advective contaminant transport can be more or less neglected. Nevertheless, there will always be a diffusive contaminant transport through the barrier which is caused by the concentration gradient. Investigations have been made to increase the sorption capacity of the barrier material by adding substances such as organoclays, zeolites, inorganic oxides and fly ashes. The contaminants taken into account where heavy metals (Pb) and for organic contaminants Toluole and Phenantrene. The paper presents results of model calculations and experiments. As a result, barrier materials can be designed {open_quotes}tailor-made{close_quotes} depending on the individual contaminant range of each site (e.g. landfills, gasworks etc.). The parameters relevant for construction such as rheological properties, compressive strength and permeability are not affected by the addition of the sorbents.

  12. Surface stability test plan for protective barriers

    International Nuclear Information System (INIS)

    Natural-material protective barriers for long-term isolation of buried waste have been identified as integral components of a plan to isolate a number of Hanford defense waste sites. Standards currently being developed for internal and external barrier performance will mandate a barrier surface layer that is resistant to the eolian erosion processes of wind erosion (deflation) and windborne particle deposition (formation of sand dunes). Thus, experiments are needed to measure rates of eolian erosion processes impacting those surfaces under different surface and climatological conditions. Data from these studies will provide information for use in the evaluation of selected surface layers as a means of providing stable cover over waste sites throughout the design life span of protective barriers. The multi-year test plan described in this plan is directed at understanding processes of wind erosion and windborne particle deposition, providing measurements of erosion rates for models, and suggesting construction materials and methods for reducing the effect of long-term eolian erosion on the barrier. Specifically, this plan describes possible methods to measure rates of eolian erosion, including field and laboratory procedure. Advantages and disadvantages of laboratory (wind tunnel) tests are discussed, and continued wind tunnel tests are recommended for wind erosion studies. A comparison between field and wind tunnel erosive forces is discussed. Plans for testing surfaces are described. Guidance is also presented for studying the processes controlling sand dune and blowout formation. 24 refs., 7 figs., 3 tabs

  13. John H. Chafee Coastal Barrier Resources System Approximate Polygons

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Coastal Barrier Resources System (CBRS) data set, produced by the U.S. Fish and Wildlife Service (Service), contains areas designated as undeveloped coastal...

  14. Minutes of Fish Barrier Workshop

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Minutes of Fish Barrier Workshop held 27 May 2009 at DOC Waikato Area Office. Lists attendees and highlights topics to be covered in Fish Barrier Workshop.

  15. Design

    Science.gov (United States)

    Buchanan, Richard; Cross, Nigel; Durling, David; Nelson, Harold; Owen, Charles; Valtonen, Anna; Boling, Elizabeth; Gibbons, Andrew; Visscher-Voerman, Irene

    2013-01-01

    Scholars representing the field of design were asked to identify what they considered to be the most exciting and imaginative work currently being done in their field, as well as how that work might change our understanding. The scholars included Richard Buchanan, Nigel Cross, David Durling, Harold Nelson, Charles Owen, and Anna Valtonen. Scholars…

  16. Design

    DEFF Research Database (Denmark)

    Volf, Mette

    2009-01-01

    Design - proces og metode går bag om designerens arbejde og giver et indblik i den skabelsesproces, som designeren er involveret i. Bogen er enestående, fordi den fokuserer på processens flygtige og komplekse karakter, afmystificerer den og gør den operationel - uden at fjerne dens magi. Ud over...

  17. Sonic Crystal Noise Barriers

    OpenAIRE

    Chong, Yung

    2012-01-01

    An alternative road traffic noise barrier using an array of periodically arranged vertical cylinders known as a Sonic Crystal (SC) is investigated. As a result of multiple (Bragg) scattering, SCs exhibit a selective sound attenuation in frequency bands called band gaps or stop bands related to the spacing and size of the cylinders. Theoretical studies using Plane Wave Expansion (PWE), Multiple Scattering Theory (MST) and Finite Element Method (FEM) have enabled study of the performance of SC ...

  18. PHARMACOVIGILANCE: BARRIERS AND CHALLENGES

    OpenAIRE

    Varma, S. K.; RAPELLIWAR A; S. Sutradhar; THAWARE P; Misra, A. K.

    2013-01-01

    Pharmacovigilance is a new discipline which deals with adverse drug or any drug related problems. Pharmacovigilance programme was not bed of roses but its path is laid with challenges and barriers. It is facing obstacles from deficiency from professional health personal to web-based sale of drugs, counterfeit drug to self-medication, etc. It is an integral part of the health sector and identification and reporting of adverse drug effects will have a positive impact on the public health. Impro...

  19. Thermal barrier coating materials

    Directory of Open Access Journals (Sweden)

    David R. Clarke

    2005-06-01

    Full Text Available Improved thermal barrier coatings (TBCs will enable future gas turbines to operate at higher gas temperatures. Considerable effort is being invested, therefore, in identifying new materials with even better performance than the current industry standard, yttria-stabilized zirconia (YSZ. We review recent progress and suggest that an integrated strategy of experiment, intuitive arguments based on crystallography, and simulation may lead most rapidly to the development of new TBC materials.

  20. Barrier infrared detector

    Science.gov (United States)

    Ting, David Z. (Inventor); Khoshakhlagh, Arezou (Inventor); Soibel, Alexander (Inventor); Hill, Cory J. (Inventor); Gunapala, Sarath D. (Inventor)

    2012-01-01

    A superlattice-based infrared absorber and the matching electron-blocking and hole-blocking unipolar barriers, absorbers and barriers with graded band gaps, high-performance infrared detectors, and methods of manufacturing such devices are provided herein. The infrared absorber material is made from a superlattice (periodic structure) where each period consists of two or more layers of InAs, InSb, InSbAs, or InGaAs. The layer widths and alloy compositions are chosen to yield the desired energy band gap, absorption strength, and strain balance for the particular application. Furthermore, the periodicity of the superlattice can be "chirped" (varied) to create a material with a graded or varying energy band gap. The superlattice based barrier infrared detectors described and demonstrated herein have spectral ranges covering the entire 3-5 micron atmospheric transmission window, excellent dark current characteristics operating at least 150K, high yield, and have the potential for high-operability, high-uniformity focal plane arrays.

  1. 高速公路交通噪声仿真模拟及声屏障设计研究%Simulation of Highway Traffic Noise and Research of Sound Barrier Design

    Institute of Scientific and Technical Information of China (English)

    刘月红; 程为波; 李国旗

    2015-01-01

    Based on a case study of a highway project ,the impact and control measures of traffic noise pollution were an-alyzed and discussed .First of all ,the traffic noise in the Xiangyang village where the highway is partially located was monitored to analyze the noise pollution .And then ,the prediction model of noise pollution was built by using Cadna/A software .According to the model ,the traffic noise contribution value was compounded by the background environment noise to determine the characteristics of the noise pollution and its development trend .Based on the analysis ,the design parameters of the noise barrier were calculated .The simulation results showed that noise pollution was more serious dur-ing the night than that of the daytime ,with the increasing of the traffic volumn ,the noise pollution became more serious . The traffic noise exceeding value was 1 .9 dB(A)in the daytime of 2014 ,10 .1 dB(A)in the nighttime of 2014 ;and it would be 4 .9 dB(A)in the daytime of 2028 ,13 .2 dB(A)in the nighttime of 2028 .So the sound barrier of 490 meters in length and 3 .2 meters in height was recommended for the noise pollution control ,which would meet the practical noise reduction requirements before 2028 .Moreover ,track monitoring of traffic noise pollution should be done ,and some funds for installing sound insulation windows for some residents should be set up .%以某高速公路项目为依托,研究交通噪声污染影响及防治措施。通过对高速公路沿线向阳村的声环境进行实际监测,分析现状噪声值。利用 Cadna/A 噪声模拟软件进行噪声仿真模拟,对交通噪声贡献值与环境噪声背景值进行叠加计算,分析噪声污染特点及发展趋势,计算确定声屏障设计参数。结果表明:夜间噪声污染更为严重,噪声污染随着交通量增大越发严重。2014年昼间超标值为1.9 dB(A),夜间超标值为10.1 dB(A);2028年昼间超标值为4.9 dB

  2. Improving efficiency of a global barrier operation in a parallel computer

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-10-04

    Performing a global barrier operation in a parallel computer that includes compute nodes coupled for data communications, where each compute node executes tasks, with one task on each compute node designated as a master task, including: for each task on each compute node until all master tasks have joined a global barrier: determining whether the task is a master task; if the task is not a master task, joining a single local barrier; if the task is a master task, joining the global barrier and the single local barrier only after all other tasks on the compute node have joined the single local barrier.

  3. AIDS, STDs encourage use of barrier methods.

    Science.gov (United States)

    Herndon, N

    1993-08-01

    Condom use in the Dominican Republic is being promoted, in part due to the spread of AIDS and sexually transmitted diseases (STDs). 90% of the married women using contraception prefer sterilization, oral contraceptives, IUDs, subdermal implants, or injectables. Barrier methods have never been very popular (5%). Cultural bias may account for some of the avoidance of barrier methods. Men complain about the effects on pleasure and spontaneity. There is uncertainty about what emphasis family planning (FP) programs should place on STD prevention; STD services would make FP popular but also could strain existing services and financial resources. Educational efforts to encourage barrier use are hampered by the lack of access to indoor plumbing, since most barrier methods are messy. Cost may be another limitation on widespread use. PROFAMILIA has been active in promoting the diaphragm and spermicide use. Counseling includes the new vaginal contraceptive film that contains a N-9 spermicide that dissolves on contact. Demand for the film is just now appearing. Research is needed to determine what degree of protection is provided against HIV infections. The female condom is still expensive and men may also find this method objectionable. Pharmacies are the chief source of barrier methods, but pharmacies do not provide counseling. Efforts have been made to teach sex workers with contraceptive messages. Free condoms have been offered in hourly rate hotels since 1987. A study of condom use within these hotels found that most people do not use the condoms (12%) usage. The range of usage varied with the quality of the hotel; condom use was greatest at more expensive ones (28% versus 5% at cheap hotels). A survey of use of instructional materials left in hotels found that 25% of the customers took the printed materials. PMID:12345033

  4. A New Type of Photoelectric Response in a Double Barrier Structure with a Wide Quantum Well

    Institute of Scientific and Technical Information of China (English)

    ZHOU Xia; ZHENG Hou-Zhi

    2005-01-01

    @@ We have calculated the photoelectric response in a specially designed double barrier structure. It has been verified that a transfer of the internal photovoltaic effect in the quantum well to the tunnelling transport through above-barrier quasibound states of the emitter barrier may give rise to a remarkable photocurrent.

  5. PRIORITISING LEAN CONSTRUCTION BARRIERS IN UGANDA'S CONSTRUCTION INDUSTRY

    Directory of Open Access Journals (Sweden)

    Henry Mwanaki Alinaitwe

    2009-06-01

    Full Text Available Engaging in lean construction efforts could prove to be highly rewarding for building firms in Uganda. However, lean construction is risky and can be disastrous if not properly managed. Lean production efforts in some other countries have not been successful due to the many barriers to its successful implementation. To enable sound lean construction efforts and to increase the chances of success in eliminating waste, a thorough investigation of the barriers is essential. This study presents 31 barriers and investigates their influence (strength on the success of lean construction initiatives. Structured interviews were carried out with technical managers of building firms to assess their perception of the barriers to lean production based on their experience at their firms. The strongest barrier is the provision of inputs exactly when required. Additionally, the barriers were ranked according to the ease of overcoming each. The easiest barrier to overcome is keeping the required items in the right place. Finally, a graphical aid is provided to enable decision makers to concentrate their efforts on the influential (strong, yet easy to overcome barriers. A lack of buildable designs and a participative management style for the workforce are the most important barriers to successful waste reduction in terms of strength and ease of overcoming. On the other hand, a lack of an organisational culture that supports teamwork, a lack of prefabrication and a lack of knowledgeable and skilled workers are regarded as low in strength, and at the same time difficult to overcome.

  6. Design and experimental testing of air slab caps which convert commercial electron diodes into dual purpose, correction-free diodes for small field dosimetry

    International Nuclear Information System (INIS)

    Purpose: Two diodes which do not require correction factors for small field relative output measurements are designed and validated using experimental methodology. This was achieved by adding an air layer above the active volume of the diode detectors, which canceled out the increase in response of the diodes in small fields relative to standard field sizes. Methods: Due to the increased density of silicon and other components within a diode, additional electrons are created. In very small fields, a very small air gap acts as an effective filter of electrons with a high angle of incidence. The aim was to design a diode that balanced these perturbations to give a response similar to a water-only geometry. Three thicknesses of air were placed at the proximal end of a PTW 60017 electron diode (PTWe) using an adjustable “air cap”. A set of output ratios (ORDetfclin) for square field sizes of side length down to 5 mm was measured using each air thickness and compared to ORDetfclin measured using an IBA stereotactic field diode (SFD). kQclin,Qmsrfclin,fmsr was transferred from the SFD to the PTWe diode and plotted as a function of air gap thickness for each field size. This enabled the optimal air gap thickness to be obtained by observing which thickness of air was required such that kQclin,Qmsrfclin,fmsr was equal to 1.00 at all field sizes. A similar procedure was used to find the optimal air thickness required to make a modified Sun Nuclear EDGE detector (EDGEe) which is “correction-free” in small field relative dosimetry. In addition, the feasibility of experimentally transferring kQclin,Qmsrfclin,fmsr values from the SFD to unknown diodes was tested by comparing the experimentally transferred kQclin,Qmsrfclin,fmsr values for unmodified PTWe and EDGEe diodes to Monte Carlo simulated values. Results: 1.0 mm of air was required to make the PTWe diode correction-free. This modified diode (PTWeair) produced output factors equivalent to those in water at all field

  7. Modeling Safety Barriers and Defense in Depth with Mulitlevel Flow Modeling

    DEFF Research Database (Denmark)

    Lind, Morten

    2012-01-01

    and diversity to create systems with a high level of safety. Chemical industries apply similar techniques for protection of the environment against the release of toxic materials. The paper exploresdifferent ways barriers can be represented in Multilevel Flow Modeling (MFM).One of the existing flow functions...... in MFM is a barrier function. It is shown that other barrier types can be represented andthat their combination into barrier chains may be used to analyze and design levels of safety in automated processes.Suggestion for further research on barrier modeling with MFM are included.......The barrier concept plays a central role in designand operation of safety critical processes. In plant design barriers are provided as means of prevention to avoid critical process conditions which may be harmful to the environment. In plant operations barriers may beestablished and maintained...

  8. Barriers for recess physical activity

    DEFF Research Database (Denmark)

    Pawlowski, Charlotte Skau; Tjørnhøj-Thomsen, Tine; Schipperijn, Jasper;

    2014-01-01

    differences in children's perceptions of barriers to recess physical activity. Based on the socio-ecological model four types of environmental barriers were distinguished: natural, social, physical and organizational environment. METHODS: Data were collected through 17 focus groups (at 17 different schools......BACKGROUND: Many children, in particular girls, do not reach the recommended amount of daily physical activity. School recess provides an opportunity for both boys and girls to be physically active, but barriers to recess physical activity are not well understood. This study explores gender...... and girls identified the same barriers, there were both inter- and intra-gender differences in the perception of these barriers. Weather was a barrier for all children, apart from the most active boys. Conflicts were perceived as a barrier particularly by those boys who played ballgames. Girls said...

  9. Barrier mechanisms in the Drosophila blood-brain barrier

    Directory of Open Access Journals (Sweden)

    Samantha Jane Hindle

    2014-12-01

    Full Text Available The invertebrate blood-brain barrier field is growing at a rapid pace and, in recent years, studies have shown a physiologic and molecular complexity that has begun to rival its vertebrate counterpart. Novel mechanisms of paracellular barrier maintenance through GPCR signaling were the first demonstrations of the complex adaptive mechanisms of barrier physiology. Building upon this work, the integrity of the invertebrate blood-brain barrier has recently been shown to require coordinated function of all layers of the compound barrier structure, analogous to signaling between the layers of the vertebrate neurovascular unit. These findings strengthen the notion that many blood-brain barrier mechanisms are conserved between vertebrates and invertebrates, and suggest that novel findings in invertebrate model organisms will have a significant impact on the understanding of vertebrate BBB functions. In this vein, important roles in coordinating localized and systemic signaling to dictate organism development and growth are beginning to show how the blood-brain barrier can govern whole animal physiologies. This includes novel functions of blood-brain barrier gap junctions in orchestrating synchronized neuroblast proliferation, and of blood-brain barrier secreted antagonists of insulin receptor signaling. These advancements and others are pushing the field forward in exciting new directions. In this review, we provide a synopsis of invertebrate blood-brain barrier anatomy and physiology, with a focus on insights from the past 5 years, and highlight important areas for future study.

  10. Preliminary engineering specifications for a test demonstration multilayer protective barrier cover system

    International Nuclear Information System (INIS)

    This report presents preliminary engineering specifications for a test protective barrier cover system and support radiohydrology facility to be constructed at the Hanford Protective Barrier Test Facility (PBTF). Construction of this test barrier and related radiohydrology facility is part of a continuing effort to provide construction experience and performance evaluation of alternative barrier designs used for long-term isolation of disposed radioactive waste materials. Design specifications given in this report are tentative, based on interim engineering and computer simulation design efforts. Final definitive design specifications and engineering prints will be produced in FY 1986. 6 refs., 10 figs., 1 tab

  11. Opportunities and barriers to straw construction

    DEFF Research Database (Denmark)

    White, Caroline Meyer; Howard, Thomas J.; Lenau, Torben Anker

    2012-01-01

    solution for these demands, while also offering the opportunity for very financially competitive solutions, it is of interest to determine their appropriateness in the design phase of a building. Through a study carried out by means of a review of the current state of the-art literature on straw...... construction, and a series of qualitative interviews with a variety of stakeholders from previous straw build housing projects, results were gathered to find the most influential motives, barriers and considerations for straw build housing construction. Based on this empirical data, a design guide has been...... dealt with and thus perceived as a barrier to straw build, rather than simply a problem of a general character....

  12. Technical barrier challenges

    Institute of Scientific and Technical Information of China (English)

    李思佳

    2014-01-01

    according to a famouse report,the foreign Technical Barriers to Trade(TBT)have some effects on the exports of the People’s Republic of China.Major findings are as follows:(1)TBT makes it more difficult for China to export;(2)TBT increases the costs of Chinese export commodities;(3)TBT causes friction and confilicts in the international trade;(4)SOME developed countries have moved their phase-outs to China and other developing countries,which have become victims of TBT.

  13. Technical barrier challenges

    Institute of Scientific and Technical Information of China (English)

    李思佳

    2014-01-01

    according to a famouse report,the foreign Technical Barriers to Trade(TBT) have some effects on the exports of the People's Republic of China.Major findings are as follows:(1)TBT makes it more difficult for China to export;(2)TBT increases the costs of Chinese export commodities;(3)TBT causes friction and confilicts in the international trade;(4)SOME developed countries have moved their phase-outs to China and other developing countries,which have become victims of TBT.

  14. Tearing Down Disciplinary Barriers

    Science.gov (United States)

    Roederer, Juan G.

    1988-05-01

    Profesor Hannes Alfvén's life-long battle against scientific narrow-mindedness and parochial approaches to the solution of scientific problems is well known and deeply appreciated by this author. In this article the new interdisciplinary trends in science are critically examined and the psychological impacts of crumbling disciplinary barriers on the participating scientists are analyzed. Several examples of interdisciplinary research programs are discussed and some thoughts on the structural reform of scientific organizations, agencies, and universities needed to face these trends are given.

  15. Neurological disorders and barriers for neurological rehabilitation in rural areas in Uttar Pradesh: A cross-sectional study

    Directory of Open Access Journals (Sweden)

    Hirdesh Kumar

    2012-01-01

    Full Text Available Background: In India, the majority of individuals with neurological disorders are rural based and cannot even afford the cost of rehabilitation. At the same time, we do not have barrier free environment in India. Aim: This study attempts to find out the neurological disorders and barriers for neurological rehabilitation in rural areas in Uttar Pradesh, India. Setting: Rural areas in Uttar Pradesh, India. Design: It is a cross-sectional study. Materials and Methods: The study was done by means of an interview method using a questionnaire. The rural areas in Uttar Pradesh were visited personally and a data from 201 individuals was collected. Statistical Analysis Used : Data analysis was done by using descriptive statistics. Results: Out of 201 individuals, 76.6% (n=154 individuals were with polio, 12.9% (n=26 were with cerebral palsy, 7.9% (n=16 were with stroke and 2.4% (n=5 were with spinal cord injury. Reasons for not taking the treatment/discontinuation of treatment were financial problem (44%, lack of awareness (43%, family negligence (6%, transportation problem (3.5% and other environmental barriers (1%. Conclusion: In our study, we found polio to be the most prevalent disorder followed by Cerebral Palsy, Stroke and Spinal Cord Injury. Financial problem was the major barrier for neurological rehabilitation followed by lack of awareness, family negligence and transportation problem.

  16. Thermal fission rates with temperature dependent fission barriers

    Science.gov (United States)

    Zhu, Yi; Pei, J. C.

    2016-08-01

    Background: The fission processes of thermal excited nuclei are conventionally studied by statistical models which rely on inputs of phenomenological level densities and potential barriers. Therefore the microscopic descriptions of spontaneous fission and induced fission are very desirable for a unified understanding of various fission processes. Purpose: We propose to study the fission rates, at both low and high temperatures, with microscopically calculated temperature-dependent fission barriers and collective mass parameters. Methods: The fission barriers are calculated by the finite-temperature Skyrme-Hartree-Fock+BCS method. The mass parameters are calculated by the temperature-dependent cranking approximation. The thermal fission rates can be obtained by the imaginary free energy approach at all temperatures, in which fission barriers are naturally temperature dependent. The fission at low temperatures can be described mainly as a barrier-tunneling process. While the fission at high temperatures has to incorporate the reflection above barriers. Results: Our results of spontaneous fission rates reasonably agree with other studies and experiments. The temperature dependencies of fission barrier heights and curvatures have been discussed. The temperature dependent behaviors of mass parameters have also been discussed. The thermal fission rates from low to high temperatures with a smooth connection have been given by different approaches. Conclusions: Since the temperature dependencies of fission barrier heights and curvatures, and the mass parameters can vary rapidly for different nuclei, the microscopic descriptions of thermal fission rates are very valuable. Our studies without free parameters provide a consistent picture to study various fissions such as that in fast-neutron reactors, astrophysical environments, and fusion reactions for superheavy nuclei.

  17. Natural Barriers of the Geosphere at Yucca Mountain, Nevada

    Science.gov (United States)

    Arlt, H.; Kotra, J.; Mohanty, S.; Winterle, J.

    2005-05-01

    Geological repositories designed to isolate high-level radioactive waste need natural and engineered barriers that prevent or slow the release of radioactive elements into the accessible environment to acceptable regulatory limits. Under the U.S. Nuclear Regulatory Commission's (NRC's) regulations, a barrier is any material, structure, or feature that prevents or substantially reduces the rate of movement of water or radionuclides from the repository to the accessible environment. In 1982, Congress passed the Nuclear Waste Policy Act which directed the NRC to include multiple barriers in regulating geologic disposal of high-level radioactive waste. Accordingly, as provided in 10 CFR Part 63, the NRC's regulations for Yucca Mountain require a repository to include multiple barriers to ensure the system is robust and not wholly dependent on any single barrier. Any potential license application to construct a repository at Yucca Mountain must identify the multiple barriers (both natural and engineered), describe the capabilities of each barrier, and provide the technical bases for the capabilities of the barriers. The NRC believes that understanding the capability of the repository's component barriers improves understanding of the overall system. The objective of this paper is to discuss potential natural barriers of the geosphere at Yucca Mountain and describe the NRC regulatory requirements for such barriers. To better understand the natural barriers of the geosphere, it helps to divide the barriers into groups of features and their associated processes. Natural barriers, i.e., barriers not constructed by man, ideally include processes that delay the transport of radionuclides from reaching the accessible environment or limit the amount of water that can seep from a ground surface to the depth of an underground repository. Natural barriers at Yucca Mountain may include: topographic influences on precipitation runoff; soil and plants influences on evaporation and

  18. Ranking different barriers influencing on media privatization

    OpenAIRE

    Roghiyeh Jame; Seyed Mohammad Dadgaran; Ali Akbar Farhangi

    2014-01-01

    For years, there have been growing interests on cost reduction for products and services. Privatization is considered as one of the most important techniques to increase relative efficiencies of publically held firms. In this paper, we present an empirical investigation to rank important barriers on privatization of television (TV) media industry in Iran. The proposed study of this paper designs and distributes a questionnaire using a sample of 234 out of 600 graduate students who were enroll...

  19. Investigating the barriers on media privatization

    OpenAIRE

    Roghiyeh Jame; Reza Najafbeigi; Ali Akbar Farhangi; Seyed Mohammad Dadgaran

    2013-01-01

    During the past few years, there has been growing interests in reducing cost of products and services among developing countries. Privatization is believed to be one of the most important techniques to increase relative efficiencies of publically held organizations. In this paper, we study important barriers on privatization of television (TV) media industry in Iran. The proposed study of this paper designs and distributes a questionnaire using a sample of 234 out of 600 graduate students who...

  20. BARRIER PROPERTIES OF VINYLIDENE CHLORIDE COPOLYMERS

    Institute of Scientific and Technical Information of China (English)

    LI Yuesheng; WENG Zhixue; HUANG Zhiming; PAN Zuren

    1996-01-01

    The permeability coefficients of a series of copolymers of vinylidene chloride (VDC)with methyl acrylate (MA), butyl acrylate (BA) or vinyl chloride (VC) (as comonomer)to oxygen and carbon dioxide have been measured at 1.0 MPa and 30℃, while those to water vapor have been measured at 30℃ and 100% relative humidity. All the copolymers are semicrystalline. VDC/MA copolymers have lower melting temperature compared with VDC/BA copolymers, while that melting temperature of VDC/VC copolymer is higher than that of VDC/acrylate copolymers with the same VDC content. The barrier property of the copolymers is predominantly controlled by crystallite, free volume fraction, and cohesive energy. The permeability coefficients of VDC/MA copolymers to oxygen, carbon dioxide, and water vapor were successfully correlated with the ratio of free volume to cohesive energy.

  1. Barriers to entry : abolishing the barriers to understanding

    OpenAIRE

    Keppler, Jan Horst

    2009-01-01

    BARRIERS TO ENTRY: ABOLISHING THE BARRIERS TO UNDERSTANDING by Jan-Horst Keppler Professor of economics Université Paris – Dauphine, LEDa, and Université Paris I Panthéon-Sorbonne, PHARE Port.: (+33 6) 77 81 37 46; Email: . Abstract The concept of a barrier to entry has been discussed least since Bain (1956) with important contributions by Spence (1977), Dixit (1980) or Milgrom and Roberts (1982). The more recent discussion is synth...

  2. Analysis of interactions among the barriers to JIT production: interpretive structural modelling approach

    Science.gov (United States)

    Jadhav, J. R.; Mantha, S. S.; Rane, S. B.

    2015-12-01

    `Survival of the fittest' is the reality in modern global competition. Organizations around the globe are adopting or willing to embrace just-in-time (JIT) production to reinforce the competitiveness. Even though JIT is the most powerful inventory management methodologies it is not free from barriers. Barriers derail the implementation of JIT production system. One of the most significant tasks of top management is to identify and understand the relationship between the barriers to JIT production for alleviating its bad effects. The aims of this paper are to study the barriers hampering the implementation of successful JIT production and analysing the interactions among the barriers using interpretive structural modelling technique. Twelve barriers have been identified after reviewing literature. This paper offers a roadmap for preparing an action plan to tackle the barriers in successful implementation of JIT production.

  3. The "Free Money" Game.

    Science.gov (United States)

    Wilson, Carrie; Garner, Barbara

    1986-01-01

    The Free Money Game is a group activity designed to: (1) familiarize refugee students with the purpose of public assistance, which is to maintain recipients at a survival level for a limited time; and (2) make students aware of the lack of options open to welfare recipients, the depersonalization associated with the bureaucracy, and the insecurity…

  4. The Fight Free Classroom.

    Science.gov (United States)

    Whedon, Craig K.; Bakken, Jeffrey P.; Fletcher, Reginald

    2000-01-01

    Describes implementation of the Fight Free Classroom intervention (designed to decrease fighting and aggressiveness by helping students take ownership of their behavior) in an urban elementary school that included students with emotional and behavioral disorders (EBD). Overall, aggressive acts among students with and without EBD decreased…

  5. Design and fabrication of lanthanum-doped tin-silver-copper lead-free solder for the next generation of microelectronics applications in severe environment

    Science.gov (United States)

    Sadiq, Muhammad

    Tin-Lead solder (Sn-Pb) has long been used in the Electronics industry. But, due to its toxic nature and environmental effects, certain restrictions are made on its use by the European Rehabilitation of Hazardous Substances (RoHS) directive, and therefore, many researchers are looking to replace it. The urgent need for removing lead from solder alloys led to the very fast introduction of lead-free solder alloys without a deep knowledge of their behavior. Therefore, an extensive knowledge and understanding of the mechanical behavior of the emerging generation of lead-free solders is required to satisfy the demands of structural reliability. Sn-Ag-Cu (SAC) solders are widely used as lead-free replacements but their coarse microstructure and formation of hard and brittle Inter-Metallic Compounds (IMCs) have limited their use in high temperature applications. Many additives are studied to refine the microstructure and improve the mechanical properties of SAC solders including iron (Fe), bismuth (Bi), antimony (Sb) and indium (In) etc. Whereas many researchers studied the impact of novel rare earth (RE) elements like lanthanum (La), cerium (Ce) and lutetium (Lu) on SAC solders. These RE elements are known as “vitamins of metals” because of their special surface active properties. They reduce the surface free energy, refine the grain size and improve the mechanical properties of many lead free solder alloys like Sn-Ag, Sn-Cu and SAC but still a systematic study is required to explore the special effects of “La” on the eutectic SAC alloys. The objective of this PhD thesis is to extend the current knowledge about lead free solders of SAC alloys towards lanthanum doping with varying environmental conditions implemented during service. This thesis is divided into six main parts.

  6. 自由锻造液压机的技术现状及设计分析%Technique status and design analysis of free forging hydraulic press

    Institute of Scientific and Technical Information of China (English)

    谢广玉; 李秀珠; 胡海燕

    2013-01-01

    阐述了自由锻造液压机的发展过程和我国锻造压机的技术现状,对自由锻造液压机的几种结构型式和传动方式进行了比较,说明了锻造油压机的技术特点.%The developing process of free forging hydraulic press and technique status in China has been described in the text. Several structural modes and transmission modes of free forging hydraulic press have been compared, and the technical characteristics of forging hydraulic press have been introduced.

  7. Overview of OBPR Free Flyer System Concept

    Science.gov (United States)

    Leung, Ronald Y.; Lieberman, Alvin S.

    2003-01-01

    Contents include the following:OBPR free flyer theme. OBPR free flyer technical activity last 2 years. GSFC integrated mission design center (IMDC) studies. Free flyer assumptions and goals. Free flyer total payload reference concept capabilities. FFM reference payload requirements. FFM mission. FFM medium summary. FFH block diagram FFH spacecraft configuration.concept.

  8. Deep inelastic scattering near the Coulomb barrier

    Energy Technology Data Exchange (ETDEWEB)

    Gehring, J.; Back, B.; Chan, K. [and others

    1995-08-01

    Deep inelastic scattering was recently observed in heavy ion reactions at incident energies near and below the Coulomb barrier. Traditional models of this process are based on frictional forces and are designed to predict the features of deep inelastic processes at energies above the barrier. They cannot be applied at energies below the barrier where the nuclear overlap is small and friction is negligible. The presence of deep inelastic scattering at these energies requires a different explanation. The first observation of deep inelastic scattering near the barrier was in the systems {sup 124,112}Sn + {sup 58,64}Ni by Wolfs et al. We previously extended these measurements to the system {sup 136}Xe + {sup 64}Ni and currently measured the system {sup 124}Xe + {sup 58}Ni. We obtained better statistics, better mass and energy resolution, and more complete angular coverage in the Xe + Ni measurements. The cross sections and angular distributions are similar in all of the Sn + Ni and Xe + Ni systems. The data are currently being analyzed and compared with new theoretical calculations. They will be part of the thesis of J. Gehring.

  9. Ballistic impact response of a coarse-aggregate barrier

    International Nuclear Information System (INIS)

    The physical understanding of the damage inflicted to a protective barrier resulting from impact with a projectile is paramount to the intelligent design of advanced protective systems. The configuration of the protective barrier used for ballistic impact studies depends upon the overall protective device that the barrier is to represent. Although many barriers are homogeneous in configuration, a much broader class of barriers involves a non-uniform agglomeration of components. Such barriers can conceivably represent the means of protection for ammunition bunkers, nuclear reactors, armored military vehicles, or any asset for which protection against projectile impact is desired. Here, an experiment-oriented investigation aimed at gaining insight and understanding of the physical phenomena that occur when a projectile impacts a thin barrier consisting of a uniform, coarse aggregate was performed at the US Army Research Laboratory. The thin barrier target was an assembly of solid steel cylinders oriented in a 15-by-15 rod square-packed array. The projectile consisted of a solid aluminum cylinder with a diameter of approximately 2.5 aggregate diameters and a length of 1.25 aggregate element lengths. The impact velocity was 2 km/s. The data collected consisted of the crater size in the barrier, plastic deformation of individual cylinders, a lateral damage wave velocity from the strain gage signals, and the residual penetrator length. A detailed analysis of the damage inflicted on the aggregate elements of the barrier was performed. The analysis focused primarily on the steel cylinders that resided outside of the eroded crater zone. Iso-strain contours were mapped on the face of the barrier to shed insight into the contact mechanics of the individual aggregate elements. A semi-empirical aggregate deformation model was created to predict the magnitude of deformation that occurs to cylinders located outside the physical crater

  10. 自由版式与栅格系统在企业型录设计中的应用%Application of Free Layout and Grid Systems in Enterprise Catalogue Design

    Institute of Scientific and Technical Information of China (English)

    秦岁明; 周应敦

    2012-01-01

    Facing the status of information competition at home and abroad, in order to facilitate the development of more scientific, convenient and efficient layout design modes and contribute to the progress of visual communication design, it analyzed the dialectic relation, the reflected regularity and the development trend of free layout and grid systems in enterprise catalogue design from the viewpoint of the current competition in information faced by domestic and overseas enterprises, the application of free layout and grid systems to enterprise catalogue design and the needs for enterprise catalogue design.%面对国内外企业信息化竞争的现状,根据国内外企业型录设计中运用自由版式与栅格系统的实践,以及国内企业型录设计的需要,分析了自由版式与栅格系统在企业型录设计中的对立统一关系、体现的规律性及发展变革性创新趋势,以利于探寻更科学、便捷、有效的版式设计模式,服务于视觉传达设计事业。

  11. The design of cobalt-free, nickel-based alloy powder (Ni-3) used for sealing surfaces of nuclear power valves and its structure of laser cladding coating

    International Nuclear Information System (INIS)

    Research highlights: → The Ni-3 Co-free alloy coating prepared by laser welding. → Ni-3 alloy has excellent combination with stainless steel base. → Ni-3 alloy containing those strengthening phases could have excellent wear resistance and anti-oxidation ability at high temperature. - Abstract: To meet the demand of cobalt-free for the cladding coating materials used on sealing surface of nuclear power valves, a new Co-free, Ni-Cr based alloy powder (Ni-3) has been developed. It has been successfully coated on the surface of stainless steel as the strengthening layer. The XRD result reveals that the primary phase of cladding coating is Ni-based solid solution, and the carbides M7C3 and M23C6 as well as several A3B types of γ' strengthening phases. It indicates that the alloy possesses the high wear resistance, good corrosion resistance and high temperature tolerance. The test results suggest that the micro-hardness of Ni-3 corresponds to that of alloy Stellite 6 which containing cobalt and currently used as material for nuclear power valves. Hence, the developed Ni-3 alloy powder can be the hopeful candidate material for Co-free cladding material used on the surface of nuclear power valves; it can reduce the nuclear pollution and save the expensive metals.

  12. The design of cobalt-free, nickel-based alloy powder (Ni-3) used for sealing surfaces of nuclear power valves and its structure of laser cladding coating

    Energy Technology Data Exchange (ETDEWEB)

    Fu Geyan, E-mail: fugeyan@suda.edu.c [School of Mechanical and Electric Engineering, Soochow University, Suzhou 215021 (China); Liu Shuang [School of Mechanical and Electric Engineering, Soochow University, Suzhou 215021 (China); Fan Jiwei [School of Materials Science and Chemical Engineering, Zhongyuan University of Technology, Zhengzhou 450007 (China)

    2011-05-15

    Research highlights: The Ni-3 Co-free alloy coating prepared by laser welding. Ni-3 alloy has excellent combination with stainless steel base. Ni-3 alloy containing those strengthening phases could have excellent wear resistance and anti-oxidation ability at high temperature. - Abstract: To meet the demand of cobalt-free for the cladding coating materials used on sealing surface of nuclear power valves, a new Co-free, Ni-Cr based alloy powder (Ni-3) has been developed. It has been successfully coated on the surface of stainless steel as the strengthening layer. The XRD result reveals that the primary phase of cladding coating is Ni-based solid solution, and the carbides M{sub 7}C{sub 3} and M{sub 23}C{sub 6} as well as several A{sub 3}B types of {gamma}' strengthening phases. It indicates that the alloy possesses the high wear resistance, good corrosion resistance and high temperature tolerance. The test results suggest that the micro-hardness of Ni-3 corresponds to that of alloy Stellite 6 which containing cobalt and currently used as material for nuclear power valves. Hence, the developed Ni-3 alloy powder can be the hopeful candidate material for Co-free cladding material used on the surface of nuclear power valves; it can reduce the nuclear pollution and save the expensive metals.

  13. Collective Phenomena In Volume And Surface Barrier Discharges

    Science.gov (United States)

    Kogelschatz, U.

    2010-07-01

    Barrier discharges are increasingly used as a cost-effective means to produce non-equilibrium plasmas at atmospheric pressure. This way, copious amounts of electrons, ions, free radicals and excited species can be generated without appreciable gas heating. In most applications the barrier is made of dielectric material. In laboratory experiments also the use of resistive, ferroelectric and semiconducting materials has been investigated, also porous ceramic layers and dielectric barriers with controlled surface conductivity. Major applications utilizing mainly dielectric barriers include ozone generation, surface cleaning and modification, polymer and textile treatment, sterilization, pollution control, CO2 lasers, excimer lamps, plasma display panels (flat TV screens). More recent research efforts are also devoted to biomedical applications and to plasma actuators for flow control. Sinu- soidal feeding voltages at various frequencies as well as pulsed excitation schemes are used. Volume as well as surface barrier discharges can exist in the form of filamentary, regularly patterned or laterally homogeneous discharges. Reviews of the subject and the older literature on barrier discharges were published by Kogelschatz (2002, 2003), by Wagner et al. (2003) and by Fridman et al. (2005). A detailed discussion of various properties of barrier discharges can also be found in the recent book "Non-Equilibrium Air Plasmas at Atmospheric Pressure" by Becker et al. (2005). The physical effects leading to collective phenomena in volume and surface barrier discharges will be discussed in detail. Special attention will be given to self-organization of current filaments. Main similarities and differences of the two types of barrier discharges will be elaborated.

  14. 适用于老年人的无障碍智能家居产品设计研究%RESEARCH ON BARRIER FREE INTELLIGENT HOME FURNISHING PRODUCTS DESIGN SUITABLE FOR THE ELDERLY

    Institute of Scientific and Technical Information of China (English)

    许晓云; 田静

    2013-01-01

    智能家居是通过构建高效的智能住宅设施与家庭事务管理系统,来提升家居生活安全性、便利性、舒适性、艺术性、节能环保效果的一种家居方式.智能家居能够用“机器适应人”的方式来解决老年人的居家生活问题,在无障碍领域能够得到很好的应用.本文运用马斯洛理论分析了老年人对于居家生活的需求要素,提出了智能家居在老年人生活中的应用以及设计原则.

  15. Exposure, Uptake, and Barriers

    Science.gov (United States)

    Baeza-Squiban, Armelle; Lanone, Sophie

    The nanotechnologies market is booming, e.g., in the food industry (powder additives, etc.) and in medical applications (drug delivery, prosthetics, diagnostic imaging, etc.), but also in other industrial sectors, such as sports, construction, cosmetics, and so on. In this context, with an exponential increase in the number of current and future applications, it is particularly important to evaluate the problem of unintentional (i.e., non-medical) exposure to manufactured nanoparticles (so excluding nanoparticles found naturally in the environment). In this chapter, we begin by discussing the various parameters that must be taken into account in any serious assessment of exposure to man-made nanoparticles. We then list the potential routes by which nanoparticles might enter into the organism, and outline the mechanisms whereby they could get past the different biological barriers. Finally, we describe the biodistribution of nanoparticles in the organism and the way they are eliminated.

  16. Countermeasures and barriers

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, Johannes [Oersted - DTU, Automation, Kgs. Lyngby (Denmark)

    2005-10-01

    In 1973 Haddon proposed ten strategies for reducing and avoiding damages based on a model of potential harmful energy transfer (Haddon, 1973). The strategies apply to a large variety of unwanted phenomena. Haddon's pioneering work on countermeasures has had a major influence on later thinking about safety. Considering its impact it is remarkable that the literature offers almost no discussions related to the theoretical foundations of Haddon's countermeasure strategies. The present report addresses a number of theoretical issues related to Haddon's countermeasure strategies, which are: 1) A reformulation and formalization of Haddon's countermeasure strategies. 2) An identification and description of some of the problems associated with the term 'barrier'. 3) Suggestions for a more precise terminology based on the causal structure of countermeasures. 4) Extending the scope of countermeasures to include sign-based countermeasures. (au)

  17. PHARMACOVIGILANCE: BARRIERS AND CHALLENGES

    Directory of Open Access Journals (Sweden)

    VARMA S. K

    2013-01-01

    Full Text Available Pharmacovigilance is a new discipline which deals with adverse drug or any drug related problems. Pharmacovigilance programme was not bed of roses but its path is laid with challenges and barriers. It is facing obstacles from deficiency from professional health personal to web-based sale of drugs, counterfeit drug to self-medication, etc. It is an integral part of the health sector and identification and reporting of adverse drug effects will have a positive impact on the public health. Improvement in knowledge in pharmacovigilance and communication from the top level to the grass-root level in the health sector will help in proper implementation of the programme. Patient should be educated to report any adverse effects after taking drug and stop relaying on acquiring information related to drugs in web. Proper detection, reporting and analysis would help to implement the programme for the betterment of society.

  18. Countermeasures and barriers

    International Nuclear Information System (INIS)

    In 1973 Haddon proposed ten strategies for reducing and avoiding damages based on a model of potential harmful energy transfer (Haddon, 1973). The strategies apply to a large variety of unwanted phenomena. Haddon's pioneering work on countermeasures has had a major influence on later thinking about safety. Considering its impact it is remarkable that the literature offers almost no discussions related to the theoretical foundations of Haddon's countermeasure strategies. The present report addresses a number of theoretical issues related to Haddon's countermeasure strategies, which are: 1) A reformulation and formalization of Haddon's countermeasure strategies. 2) An identification and description of some of the problems associated with the term 'barrier'. 3) Suggestions for a more precise terminology based on the causal structure of countermeasures. 4) Extending the scope of countermeasures to include sign-based countermeasures. (au)

  19. Racial Trade Barriers?

    DEFF Research Database (Denmark)

    Bjerre, Jacob Halvas

    Aryanization is associated with Nazi Germany's policies to exclude Jews in the Germany from the economy in the pre-war years, but I will show it was a global policy from 1937. The utopian goal of international Aryanization was the total removal of Jews who traded with Germany anywhere in the world....... This paper analyzes the racial policies pursued in the foreign trade and argues that we need to recognize Aryanization as a world-wide policy in order to fully understand its character and possible consequences. I focus on the pre-war period and analyze the case of Denmark from three different perspectives......: perpetrators, victims and bystanders. The analysis will show that race, economy and foreign trade were combined in an attempt to raise racial trade barriers. This forced the question of German racial policies on the Danish government, Danish-Jewish businesses, and German companies involved in foreign trade...

  20. A Framework for Analyzing Technical Trade Barriers in Agricultural Markets

    OpenAIRE

    Roberts, Donna; Josling, Timothy E.; Orden, David

    1999-01-01

    Technical trade barriers are increasingly important in the international trade of agricultural products. Designing technical trade measures that can satisfy the growing demand for food safety, product differentiation, environmental amenities, and product information at the lowest cost to the consumer and to the international trading system requires an understanding of the complex economics of regulatory import barriers. This report proposes a definition and classification scheme to frame disc...