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Sample records for barrel ecal eb

  1. Installation of CMS EB (ECAL Barrel) Supermodules 5 and 13 inside HB+ (HCAL Barrel) on 26/27 April 2006

    CERN Multimedia

    2006-01-01

    The first two barrel "supermodules" of the CMS Electromagnetic Calorimeter (ECAL) have been inserted into the barrel hadron calorimeter (HCAL) in the CMS experimental hall (called SX5) in Cessy in preparation for the forthcoming magnet test and cosmic challenge (MTCC). Each of the two supermodules contains 1700 lead tungstate crystals in glass-fibre alveolar support structures, with associated avalanche photodiodes (APDs, for scintillation light detection), electronics and cooling system.

  2. Installation of CMS EB (ECAL Barrel) Supermodules 5 and 13 inside HB+ (HCAL Barrel) on 26/27 April 2006

    CERN Document Server

    Ken Bell, RAL

    2006-01-01

    The first two barrel "supermodules" of the CMS Electromagnetic Calorimeter (ECAL) have been inserted into the barrel hadron calorimeter (HCAL) in the CMS experimental hall (called SX5) in Cessy in preparation for the forthcoming magnet test and cosmic challenge (MTCC). Each of the two supermodules contains 1700 lead tungstate crystals in glass-fibre alveolar support structures, with associated avalanche photodiodes (APDs, for scintillation light detection), electronics and cooling system. See also the document CMS-PHO-OREACH-2006-019. The first two pictures show the two supermodules in their final position. Fig. 3: the "enfourneur" in position on the HB Cradle. Fig. 4: supermodule n. 5 and extension rails being lifted to the enforneur. Figs. 5-6: supermodule approaching the enforneur. Fig. 7: rotating the Enfourneur to the correct phi direction Figs. 8-9: aligning the extension rails with the rails inside HB and view from inside HB, once the rails are aligned. Figs. 10-12: insertion of supermodule n. 5. Fig. ...

  3. Temperature control of CMS Barrel ECAL (EB) : computational thermo-hydraulic model for dynamic behaviour, control aspects

    CERN Document Server

    Wertelaers, P

    2010-01-01

    The current design foresees a central heat exchanger followed by a controlled post heater, for all ECAL. We discuss the scheme and try to assess its performance, from a Barrel viewpoint. This is based on computational work. The coolant transfer pipes play an essential role in building a dynamical model. After some studies on the behaviour of the cooling circuit itself, a strong yet simple controller is proposed. Then, the system with feedback control is scrutinized, with emphasis on disturbance rejection. The most relevant disturbances are cooling ripple, pipe heat attack, and electronics’ switching.

  4. ECAL

    CERN Multimedia

    D. Barney.

    Four words summarize the evolution of the ECAL system during the past six months: "Never a dull moment"! Following the completion of the on-detector systems (with the installation of the Preshower) the remaining pieces were comprised of some off-detector electronics cards. The ECAL Endcap TCCs (Trigger Concentrator Cards) have now all been produced and installed, with some spares under construction. The full set of Preshower ESDCCs (Data Concentrator Cards) have also been installed although about half will eventually be replaced with newer (more reliable) ones. Commissioning of these cards is in full swing, along with the corresponding firmware, software and database interfaces. Readout of the EB and EE (Electromagnetic Barrel and Endcap respectively) is also in the final stages of commissioning. Two readout options are available: ZS (Zero Suppression) is a relatively straightforward algorithm that reads-out all crystals that have energy deposits above a certain threshold; SRP (Selective Re...

  5. ECAL

    CERN Multimedia

    David Petyt

    2013-01-01

    One half of the ECAL barrel (EB–) and both endcaps (EE) participated in the CMS Global Run in November (GRiN). This was used as an opportunity to exercise the ECAL DAQ and trigger systems following software development work during LS1 and verify the operation of ECAL with an increased latency of +12 BX. It was also used to check the status of EB– following the reconnection of low-voltage cables that were disconnected at the start of LS1 to allow the replacement of HCAL photodetectors. The cables in EB+ will be reconnected and re-commissioned in 2014. The GRiN was also used to verify the successful repair in September 2013 of a region of 75 channels in the positive endcap (EE+), which had not been fully operational since the LHC’s startup in late 2009. A campaign to refurbish all EB/EE low-voltage AC/DC convertors was carried out in parallel with these activities. Monitoring data (laser and LED light) has been taken regularly to measure the recovery of crystal transparency duri...

  6. First two barrel ECAL supermodules inserted in CMS HCAL

    CERN Multimedia

    K.Bell

    2006-01-01

    The first two barrel "supermodules" for the CMS Electromagnetic Calorimeter (ECAL) have been inserted into the barrel hadron calorimeter (HCAL) in the experimental hall (called SX5) in Cessy in preparation for the forthcoming magnet test and cosmic challenge (MTCC). Each of the two supermodules contains 1700 lead tungstate crystals in glass-fibre alveolar support structures, with associated avalanche photodiodes (APDs, for scintillation light detection), electronics and cooling system. The barrel ECAL will consist of 36 supermodules, many of which have already been produced (see CERN Bulletin 17-18, 2006). Team from CMS ECAL, CMS Integration and CEA-DAPNIA were involved in the insertion, with the production/integration of the supermodules themselves involving many technicians, engineers and physicists from many institutes. From left to right: Olivier Teller, Maf Alidra and Lucien Veillet.

  7. ECAL

    CERN Multimedia

    D. Barney

    2010-01-01

    The first LHC beams of 2009 and subsequent collisions provided an excellent “training ground” for the operation of all components of the ECAL, including the detectors themselves (crystals and silicon), control/readout electronics, and the triggering system based on ECAL information. The system was timed-in, triggers delivered and the resulting data proved to be of good quality providing evidence of known resonances (e.g. neutral pions) as well as accurate in-situ calibrations, as discussed in the DPG section of this Bulletin. The LHC activities also provided an opportunity to stress the other vital sides of operations – that of the people involved and the feedback tools needed to determine, very efficiently, that the detector was functioning correctly: ECAL collaborators were stationed at P5 24/7 for front-line operations, whilst the quasi-online Prompt Feedback Group (PFG) provided valuable detailed analyses within hours of the data being taken. This whole mechanism worked very...

  8. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Document Server

    P. Bloch

    ECAL Barrel The integration of the last Supermodule was completed early July. The insertion of the second half Barrel (EB+) was performed in the second half of July. The Barrel ECAL (36 Supermodules comprising 61200 channels) is now complete, and its cabling campaign has just started. Each Supermodule has been tested after insertion. The number of dead or partially-dead channels amounts to only 28 (0.05% of the total), a performance showing the excellence of the quality control during the whole construction process. The Barrel Off-detector electronics is installed in the CMS Service cavern (with the exception of a few Trigger modules), ready to be connected to the Supermodules after cabling. The ECAL DAQ has been integrated with the CMS DAQ system: at the end of August one supermodule was included in a CMS global run, allowing us to record cosmic muons in both ECAL and DTs. ECAL Endcaps The Endcaps crystal production is proceeding at full speed, and the delivery rate (summing both producers) exceeds ...

  9. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    P. Bloch

    ECAL Barrel (EB) The cabling of the ECAL Barrel services on YB0 was completed early December 2007. The team has now commissioned the complete Barrel. To run all the supermodules in parallel, it is necessary to remove the heat from the service cables on YB0. The corresponding thermal screens are being installed and, for the time being, a max¬imum of 25 supermodules has been run concurrently. EB is read out regularly with a local DAQ as well as with the central DAQ and trigger. The calorimeter trigger has also been commissioned, allowing us to trigger on cosmic muons. ECAL Endcaps (EE) The Endcaps crystal production will be completed before the end of March 2008, as planned. The gluing of the VPTs (Vacuum Photo Triodes) on the crystals and the assembly of Supercrystals (sets of 25 crystals) are proceeding at the pace of 16 Supercrystals (400 channels) per week. Two thirds of the Supercrystals needed for the complete EE have been produced. Their mounting on the Dee backplates (including the connectio...

  10. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    Philippe Bloch

    ECAL Barrel (EB) Great progress has been achieved during the last few months on Barrel commissioning. All 36 supermodules have been run concurrently during the CRUZET in early May. The EB readout has reached the expected performance and is included regularly with central DAQ.  ECAL has been used as a source of triggers during cosmic runs. ECAL Endcaps (EE) Important milestones have been recently achieved: The Endcaps crystal production was completed in mid March. The gluing of the VPTs (Vacuum Photo Triodes) on the crystals, the assembly of Supercrystals (a set of 25 crystals) and their mounting on the Dee backplates (including the connection of the laser monitoring fibers) were finished during May. The mechanical assembly of the four endcap Dees is therefore completed. The assembly of the services and electronics on the backside of the Dees’ back-plates is also proceeding at a fast speed. The laying of the high voltage cables, the inner moderator, the optical fibers for the LED stabilit...

  11. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    P. Bloch

    ECAL crystal calorimeter (EB + EE) The Barrel and Endcaps ECAL calorimeters have been used routinely in global runs. The CRAFT data have confirmed that ECAL performance is the same with or without magnetic field. The CRUZET and CRAFT runs have allowed experience to be gained with ECAL operation in many areas, in particular for the trigger and the calibration sequence using gap events (laser events and LED pulsing). More details can be found in the Commissioning/DPG report in this bulletin.   The last components remaining to be installed and commissioned are the specific Endcap Trigger modules (TCC-48). Most of the modules have been delivered to LLR and half of them are already at CERN. In parallel, large progress has been made on the validation of the TCC-48 firmware. Preshower (ES) The Preshower project has also made impressive progress during Autumn. All the elements required to complete the detector assembly are at hand. Ladder assembly, test and calibration with cosmic rays at the operating ...

  12. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    D. Barney

    2013-01-01

    The CMS ECAL, comprising barrel (EB), endcaps (EE) and preshower (ES) detectors, operated reliably throughout the 2012 (proton-proton) and early 2013 (proton-lead) running periods. The data quality was excellent, with more than 98% of the delivered luminosity declared good for physics in 2012, and close to 100% in 2013. The number of active channels – ~99% in the EB/EE and ~97% in the ES – was stable during 2012-’13. The ECAL performance, as measured by the electron energy scale and resolution and Z→ee mass resolution in both barrel and endcaps, is excellent and very stable in time (see Figure 1 for an example, and CMS-DP-2013-007: https://cds.cern.ch/record/1528235) following a dedicated calibration using the full 2012 CMS dataset. Figure 1 (a) and (b): The mass resolution of the Z peak, reconstructed from its di-electron decay mode, as a function of time for the barrel (a) and endcaps (b). The sample is inclusive (no cut on the amount of bremsstrahlung undergone...

  13. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    P. Bloch

    ECAL Barrel (EB) The main task during this fall was the connection of services of the ECAL Barrel Supermodules installed in the vacuum-tank. This work has been completed. The team is now commissioning the Supermodules using the final services (cables and optical fibers, HV and LV power supplies, cooling plant) and final electronics in the service cavern. The pace of commissioning has been limited by the availability of the cooling plant. At the time of writing, about 2/3 of the Supermodules had been signed off. ECAL Endcaps (EE) The Endcaps crystal production is proceeding fast. At the end of October, more than 10000 crystals (two thirds of the total quantity) had beem delivered. The Endcaps crystal production will be completed at the end of March 2008, as planned. The crystals testing and the gluing of the VPTs (Vacuum Photo Triodes) on the crystals follow the plan. The assembly of Supercrystals (a set of 25 crystals) is now a routine operation. All the Supercrystals for Dee1 and two thirds of those ne...

  14. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    Philippe Bloch

    ECAL Barrel (EB) As already mentioned in June, the Barrel ECAL is fully commissioned and routinely used during CRUZET runs.  Good progress has been made in the last months to ensure a stable and fully reliable operation, in particular for the Trigger path. More details can be found in the DPG report in this bulletin.     ECAL Endcaps (EE) In the June CMS bulletin, it had been announced that the Dee’s mechanical assembly had been finished end of May. However the electronics integration was still going on for the first Dee. The Summer has seen a spectacular breakthrough of the Endcap project. The electronics integration of Dee1 was completed early July, and this first Dee was transported to point 5 on July 8th. The completion of the three other Dees followed at a pace of one per week. In all cases the quality of the detector as measured in the assembly center was excellent, with all channels active and  the expected noise performance (see for example the reports pr...

  15. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    T. Tabarelli and D. Barney

    2011-01-01

    ECAL operations have been rather smooth during the past months, with few hardware problems, stable trigger rates etc. The downtimes attributed to ECAL have, however, increased recently, due to some crashes of the DAQ on the ECAL side. The frequency of problems has increased with luminosity and seems to occur more in the EE than in the EB. There are some indications suggesting these problems may be due to Single Event Upsets – radiation-induced modifications to the front-end electronics. Although this is not yet confirmed, measures are already being taken to reduce the time taken to recover from such problems in order to minimise downtime. No such problems have (yet) been seen in the ES. There has been enormous progress in improving the quality of the corrections required to take into account transparency variations of the ECAL crystals with radiation, through a detailed calibration of the response of the laser diagnostic line. The special LHC runs taken recently – 25-ns operation and h...

  16. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    2011-01-01

    All components of ECALEB, EE and ES – operated well throughout 2010 with few problems, and negligible evolution of dead channels. About 2% of the ES silicon sensors were unplugged in the second part of the year due to unacceptable increases in leakage currents attributed to radiation damage of the surfaces. The LHC winter technical stop allowed many improvements to the ECAL infrastructure at Point 5. For example, the High Voltage distribution systems for the EE and ES were both improved, with further modifications planned for the ES later in the year. Monitoring and alarming of power supplies was also improved, increasing the level of safety. Some cables in the USC and UXC were re-worked, recovering the operation of some environmental monitoring sensors and improving robustness overall. A thorough Readiness Review Workshop was organised at the end of January 2011 to review 2010 data quality and online and offline operations, and to prepare for the higher luminosities in 2011. All prese...

  17. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    T. Tabarelli

    2011-01-01

    All components of ECAL have been running smoothly throughout the 2011 run; the general health of the system is stable since 2010, with close to 99% of the channels available for energy reconstruction. Less than 3% of the registered luminosity to date has bad data quality in ECAL. About 2/3 of the data lost were affected by a low-voltage (LV) failure in one EB super-module due to a flaky contact. After prompt repair, all the remaining contacts were thoroughly checked in the late-March technical stop, with some additional repairs being carried-out. After extensive tests in late 2010 and further optimisation with first 2011 collisions, the rejection at L1 of anomalous signals ascribed to the nuclear counter effect in the APDs is now incorporated in standard running. The required factor-of-3 reduction in the lowest un-prescaled electron/photon trigger (EG12) was met, with larger reduction factors for higher transverse energies, as expected. Studies are ongoing to anticipate the anomalous signal rejection perform...

  18. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    P. Bloch

    Crystals and Bare Supermodules The last Barrel crystal was delivered on March 9th and the last (36th) Bare Supermodule was completed by April 20th. Endcaps crystal production is ramping up at both producers and the delivery rate exceeds already 1050 crystals per month. The quality of the Endcaps crystals is similar to that of the Barrel. Electronics The production of the on-detector electronics (Barrel + Endcaps) is complete. Already 10 out of the 12 crates of the Barrel Off-detector modules have been commissioned and installed in the CMS service cavern, and the integration with the global DAQ is progressing fast. The last 2 crates will be completed in August, after reception of the last Trigger Modules TCC68. The installation of the High Voltage is also progressing well, taking into account that some HV supplies are still used in the various assembly and test centres of ECAL. A large fraction of the low voltage supplies has been delivered and tested. Electronics integration As explained in the Febru...

  19. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    D. Petyt

    2013-01-01

    In a break with tradition, the ECAL general meetings during the April CMS Week were devoted to a series of brainstorming sessions, focusing on a small number of hot-topic items. These included sessions on ECAL upgrades, analysis of 2012 detector performance and resolution, software development plans and a review of the ECAL calibration sequence. These sessions were well attended and extremely productive, and have helped to define and guide the direction of the ECAL effort planned for LS1. The area of ECAL upgrades has been particularly active over the past several months. A note summarising the test-beam performance of crystal matrices, irradiated with proton fluences representative of the end of Phase 1 LHC running, has been prepared and is being reviewed by ECAL. This important note provides data to tune and validate the simulation of ECAL ageing that has been implemented in CMSSW. This simulation is being used by the ECAL group and others to evaluate the physics performance of the ECAL at the end of Pha...

  20. Production of CMS-ECAL supermodules

    CERN Multimedia

    Michael Droege, ETH-Zuerich

    2006-01-01

    CMS electromagnetic calorimeter (ECAL) electronics integration centre working on 4 barrel supermodules in parallel (end of Feb. 2006): While SM21 (red) and SM19 (green) are processed, SM13 (white) is being repaired and re-tested and SM17 (blue) is being commissioned for one week. More than 2/3 of the barrel supermodules are now ready for the integration of the electronics. Pictures 2-6 have been taken in the electronics integration centre in May 2005. Picture 7 shows the "petrified forest" on a sumermodule.

  1. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    T. Tabarelli

    2012-01-01

      ECAL has been stably running with an up-time efficiency of 99.4% during Run 2012D, with about half of the inefficiency due to a single downtime episode. More than 99% of the collected data are certified good by ECAL for offline analysis. The monitoring system and calibration chain have also been working smoothly, with an excellent stability of the new laser source, after final tuning during the technical stop in September. Some drifts in the response upon monitoring corrections and some degradation in the resolution throughout Run 2012C and 2012D have been observed and will be corrected in the next reprocessing. Calibration constants for the full 2012 dataset –– derived with well-established procedures –– are going to be delivered by the end of the pp run. In parallel to this, studies of the performance evolution have been carried out to predict the longevity of ECAL towards HL-LHC. Radiation damage effects are studied from P5 data, particularly in the end...

  2. Hybrid ECAL: Optimization and Related Developments

    CERN Document Server

    Suehara, T; Sumida, H; Ueno, H; Sudo, Y; Yoshioka, T; Kawagoe, K

    2015-01-01

    Hybrid ECAL is a cost-conscious option of electromagnetic calorimeter (ECAL) for particle flow calorimetry to be used in a detector of International Linear Collider (ILC). It is a combination of silicon-tungsten ECAL, which realizes high granularity and robust measurement of electromagnetic shower, and scintillator-tungsten ECAL, which gives affordable cost with similar performance to silicon. Optimization and a data acquisition trial in a test bench for the hybrid ECAL are described in this article.

  3. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    D. Barney

    2012-01-01

      There are no major concerns for the ECAL running and operation in 2012. The necessary ameliorations to the system were planned in December, and reviewed in a dedicated workshop at the end of January. Many interventions have taken place, mainly on the Trigger and DAQ side in order to bring all software into line with central developments (e.g. SLC5, XDAQ11 and use of SVN). In addition, steps are being taken to improve the recovery time of the system from “single event upsets (SEU)”, which are suspected to be the cause of some downtimes in 2011 (and, if so, would be more frequent in 2012 due to higher luminosities). A new blue laser, for crystal transparency monitoring, is currently being commissioned in Caltech and will be installed at P5 in March. We have optimised the ECAL zero-suppression settings applied online in preparation for the LHC running with high pile-up conditions. The algorithm to reduce the rate of anomalous signals  (“spikes”) fir...

  4. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    Roger Rusack

    Occupancy of the trigger primitives during a global run: the observed pattern is consistent with the polar angle dependence of the transverse energy equivalent of the electronic noise in the endcaps.   Progress on ECAL since the last CMS week has been mostly on three major fronts: we have continued with the installation and commissioning of the preshower detectors; the endcap calorimeter trigger has been installed and tested; and there have been many changes to the calorimeter detector control and safety systems. Both Preshower (ES) endcaps were installed in CMS on schedule, just before Easter. There followed a campaign of "first commissioning" to ensure that all services were correctly connected (electrical, optical, cooling, etc.). Apart from some optical ribbons that had to be replaced the process went rather smoothly, finishing on 23rd April. All power supplies are installed and operational. The cooling system (two branches of the joint Tracker-Preshower system) is fully fun...

  5. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    Dave Barney

    2010-01-01

    The operation of ECAL during the whole proton-proton period was very successful, with little down time. During this period we witnessed the first expected signs of radiation damage, both in the preshower detector, where we measured a small but clear increase in the current drawn by the silicon sensors (due to bulk damage) and in the endcap crystals, with the first evidence of a decreasing crystal transparency. The extent of the damage is in general as expected from simulations. However, a small fraction of the preshower sensors also show signs of unexpected surface damage. This is under investigation.
 The running period was very smooth overall but not without glitches. Among these occurrences we had a few high voltage problems in the endcaps, a low voltage connector at the preshower failed, a few unnoticed DCS alarms and our fair share of DAQ "out-of-sync". All problems were followed-up and mitigated where possible. Lessons learnt will be very useful for the long running period ahead of ...

  6. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    P. Bloch

    Crystals and Bare Supermodules Thanks to an unprecedented delivery rate, in excess of 1200 crystals per month during the last three months, the last Barrel crystals will be delivered at the end of February. The penultimate bare supermodule is under assembly; the last should be assembled in April. The first batch of Endcap crystals from the mass production has been received from China as well as two pre-series of 100 crystals from Russia. Electronics The assembly and test of off-detector electronics crates (each crate containing three triplets, each triplet comprising Data Concentrator Cards (DCC), Clock & Control System card (CCS) and Trigger & Clock Controllers (TCCs) module – i.e. enough to serve three supermodules) is progressing fast. Several crates have already been installed in the USC at point 5. The production of the specific Endcap electronics is also well advanced. For example, the test of the Front-End cards was recently completed. Electronics integration In early Autu...

  7. Upgrade of the LHCb ECAL monitoring system

    CERN Document Server

    Guz, Yu

    2015-01-01

    The LHCb ECAL is a shashlik calorimeter of 6016 cells, covering 7.68 x 6.24 m$^2$ area. To monitor the readout chain of each ECAL cell, the LHCb ECAL is equipped with a LED based monitoring system. During the LHC Run I (2009-2012) it was found that the precision of the monitoring suffers from the radiation degradation of transparency of polystyrene clear fibers used to transport the LED light to the ECAL photomultipliers. In order to improve the performance of the monitoring system, and especially in view of significant increase of LHCb working luminosity foreseen after 2018, the present plastic fibers have been replaced by radiation hard quartzfi bers. The performance of the old LHCb ECAL monitoring system during LHC Run I and the design of the upgraded system are discussed here.

  8. Optimization of layer composition for ILD ECAL

    CERN Document Server

    Sumida, Hiroki; Sudo, Yuji; Suehara, Taikan; Yoshioka, Tamaki; Kawagoe, Kiyotomo; Jeans, Daniel; Takeshita, Tohru; Kotera, Katsushige

    2016-01-01

    International Large Detector (ILD) adopts Particle Flow Algorithm (PFA) for precise measurement of multiple jets. The electromagnetic calorimeter (ECAL) of ILD has two candidates sensor technologies for PFA, which are pixelized silicon sensors and scintillator-strips with silicon photomultipliers. Pixelized silicon sensors have higher granularity for PFA, however they have an issue of cost reduction. In contrast, scintillator-strips have an advantage of relatively low cost and a disadvantage of degradation of position resolution by ghost hits, which are generated by orthogonal arrangement. Hybrid ECAL using both candidates is proposed to supplement these disadvantages. In this paper, we report an optimization study of the hybrid ECAL using detector simulation.

  9. Laser monitoring for the CMS ECAL

    Science.gov (United States)

    Rogan, Christopher; CMS ECAL Group

    2010-11-01

    The Compact Muon Solenoid (CMS) detector at the LHC is equipped with a high precision lead tungstate crystal electromagnetic calorimeter (ECAL). To ensure the stability of the calorimetric response at the level of a few per mille, every channel of the detector is monitored with a laser system. This system enables corrections for fluctuations in the detector response with high precision, in particular the expected radiation induced changes in the crystal transparency. We describe the implementation of the laser monitoring system and report results from tests on the fully equipped supermodules of the ECAL. Specifically, we discuss results concerning the dynamics of crystal transparency change from dedicated irradiation studies in test beams.

  10. Upgrade of the monitoring system of LHCb ECAL

    CERN Document Server

    Guz, Iouri; Chernov, Evgeny; Egorychev, Victor; Kandybei, Sergii; Kvaratskheliya, Tengiz; Obraztsov, Vladimir; Perret, Pascal; Philippov, Sergey; Savrina, Daria; Shatalov, Sppavel; Zakoriuchkina, Tatiana; Zhokhov, Anatoli; Zvyagintsev, Serguei

    2016-01-01

    The LHCb ECAL is a shashlik calorimeter of 6016 cells, covering 7.686.24 m2 area. To monitor the readout chain of each ECAL cell, the LHCb ECAL is equipped with a LED based monitoring system. During the LHC Run I (2009-2012) it was found that the precision of the monitoring suffers from the radiation degradation of transparency of polystyrene clear fibers used to transport the LED light to the ECAL photomultipliers. In order to improve the performance of the monitoring system, and especially in view of significant increase of LHCb working luminosity foreseen after 2018, the present plastic fibers have been replaced by radiation hard quartz fibers. The design of the upgraded version of the LHCb ECAL monitoring system is described here. The usage and performance of the new system for the ECAL calibration during the LHCb Run II are discussed.

  11. Laser monitoring for the CMS ECAL

    OpenAIRE

    Rogan, Christopher

    2010-01-01

    The Compact Muon Solenoid (CMS) detector at the LHC is equipped with a high precision lead tungstate crystal electromagnetic calorimeter (ECAL). To ensure the stability of the calorimetric response at the level of a few per mille, every channel of the detector is monitored with a laser system. This system enables corrections for fluctuations in the detector response with high precision, in particular the expected radiation induced changes in the crystal transparency. We describe the implement...

  12. Timing performance of the CMS ECAL and prospects for the future

    Science.gov (United States)

    del Re, Daniele

    2015-02-01

    The CMS electromagnetic calorimeter (ECAL) is made of about 75000 scintillating lead tungstate crystals arranged in a barrel and two endcaps. The scintillation light is read out by avalanche photodiodes in the barrel and vacuum phototriodes in the endcaps, at which point the scintillation pulse is amplified and sampled at 40 MHz by the on-detector electronics. The fast signal from the crystal scintillation enables energy as well as time measurements from the data collected in proton-proton collisions with high energy electrons and photons. The stability of the time measurement required to maintain the energy resolution is on the order of 1 ns. The single-channel time resolution of ECAL measured at beam tests for high energy showers is better than 100 ps. The time resolution achieved with the data collected in proton-proton collisions at the LHC is presented. The time precision achieved is used in important physics measurements and also allows the study of subtle calorimetric effects, such as the time response of different crystals belonging to the same electromagnetic shower. In addition, we present prospects for the high luminosity phase of the LHC, where we expect an average of 140 concurrent interactions per bunch crossing (pile-up). It is currently being studied how precision time could be exploited for pileup mitigation and for the assignment of the collision vertex for photons. In this respect, a detailed understanding of the time performance and of the limiting factors in time resolution will be important.

  13. BUSINESS MODELS FOR EXTENDING OF 112 EMERGENCY CALL CENTER CAPABILITIES WITH E-CALL FUNCTION INSERTION

    OpenAIRE

    Pop Dragos Paul; Botezatu Cornelia Paulina; Botezatu Cezar; Carutasu George

    2010-01-01

    The present article concerns present status of implementation in Romania and Europe of eCall service and the proposed business models regarding eCall function implementation in Romania. eCall system is used for reliable transmission in case of crush between In Vehicle System and Public Service Answering Point, via the voice channel of cellular and Public Switched Telephone Network (PSTN). eCall service could be initiated automatically or manual the driver. All data presented in this article a...

  14. The Super-Basket Incorporation of Conical Reinforcements in the CMS ECAL EB Support Structure

    CERN Document Server

    Lebeau, Michel; Rezvani-Naraghi, H

    2003-01-01

    This document is based on information available at the end of 2001 and summarises the main steps of an important design revision initiated at the end of 1999. Early in 2002 the design was submitted to technical reviews that validated the structural concept. With some changes affecting the material and the screwed connections clearance was given to produce a Super Basket prototype delivered in July 2002. From the assembly tests results the review committee validated the computations. Some further detail changes to the Super-Basket front connection were suggested and implemented in tests until November 2002. The committee finally gave a full approval to the design and authorised the serial production of Super-Baskets in December 2002. Technical notes accompanying the design, test and review steps since the January 2002 review will be condensed in a single document to be published in 2003.

  15. Three dimensional parametrization of electromagnetic shower in Alpha Magnetic Spectrometer Ⅱ ECAL

    Institute of Scientific and Technical Information of China (English)

    TAO Jun-Quan; CHEN He-Sheng; CHEN Gang; YANG Min; CHEN Guo-Ming; LI Zu-Hao; LI Xin-Qiao; TANG Zhi-Cheng; ZHANG Zhen; WANG Jian; L(U) Yu-Sheng

    2008-01-01

    We develop an empirical formula to parameterize the 3-dimension (3D) distribution of electromagnetic showers in the Alpha Magnetic Spectrometer Ⅱ electromagnetic calorimeter(ECAL). The formula was verified by ECAL test beam data in 2002 and found to perform well. The distribution of electron showers in the ECAL are well described by the formula, which has parameters that allow one to determine the 3D shape of electromagnetic showers in the ECAL. We use this formula to correct for lateral energy leakage and dead channels in the ECAL; good results are obtained.

  16. DVCS process at COMPASS and Ecal 1 & 2 monitoring

    CERN Document Server

    AOUADI, Mehdi

    2014-01-01

    The aim of this project is to develop and use a software to verify, offline, the calibration of the electromagnetic calorimeters Ecal 1 and Ecal 2. This software is able to show all cells in a 2D mapping of the calorimeters, it displays the LED zone or the FEM zone. If correctly defined, it is capable to divide these cells in two groups (the bad cells and the good cells). And finally, it is able to show some anomaly due to the photomultiplier or anything else.

  17. Super radiation hard vacuum phototriodes for the CMS endcap ECAL

    CERN Document Server

    Gusev, Yu I; Levchenko, L A; Lukianov, V N; Mamaeva, G A; Moroz, F V; Seliverstov, D M; Trautman, V Yu; Yakorev, D O

    2004-01-01

    The energy resolution sigma/E of the electromagnetic calorimeter (ECAL) in the energy range of 50-500 GeV is defined mainly by two terms: stochastic alpha/ root E and constant C. The photoreadout of the CMS Endcap ECAL consists of vacuum phototriodes (VPT), which are broadening a signal from n //p photoelectrons characterized by the excess noise factor F = n //p(sigma/E)**2. The technical specification of the CMS ECAL requires the value of F to be smaller than 4 in the CMS LHC environment during 10 years of detector operation. In this paper we present results of the VPT performance study in a magnetic field up to 4 T, in a gamma radiation field of 0-50 kGy and in a neutron fluence of 7 multiplied by 10**1**5n/cm**2. The standard phototriodes FEU-188 with faceplates from UV glass used in CMS ECAL as well as VPTs with super radiation hard cerium-doped glasses were investigated at the **6**0Co gamma facility, a neutron generator and a nuclear reactor in the Petersburg Nuclear Physics Institute (PNPI). The depend...

  18. T2K ECAL Test–beam Proposal

    CERN Document Server

    Wark, D; Grant, A; Muir, A; Guzowski, P; Malek, M; Noy, M; Raymond, M; Taylor, I; Uchida, Y; Vacheret, A; Van Schalkwyk, F; Walding, J; Wark, D; Wascko, M; Bertram, I; Chilingarov, A; Davies, G; Finch, A; Hatzikoutelis, A; Kormos, L; Maryon, T; Ratoff, P; Chavez, C; Kellet, L; McCauley, N; Payne, D; Sutcliffe, P; Touramanis, C; Barr, G; Smith, R; West, N; George, M; Hyndman, A; Di Lodovico, F; Owen, R A; Sacco, R; Terri, R; Andreopoulos, C; Durkin, T; Metelko, C; Nicholls, T C; Pearce, G F; Raufer, T M; Rooney, M; Thorpe, M; Weber, A; Woodward, M L; Cartwright, S L; Salih, R; Still, B; Veledar, O; Ward, G; Ward, M; Barker, G J; Carver, A; Litchfield, P; Haigh, M; Whitehead, L; Thompson, L; Touramanis, C

    2008-01-01

    The T2K experiment will search for the last unknown element of the neutrino mixing matrix. An crucial component of the near detector for this experiment is the electromagnetic calorimeter which is being built in the UK. Testbeam time is requested to test the full ECAL system, validate calibration techniques, and determine the hadronic and electromagnetic energy scale of the calorimeter.

  19. EBS Radionuclide Transport Abstraction

    Energy Technology Data Exchange (ETDEWEB)

    R. Schreiner

    2001-06-27

    The purpose of this work is to develop the Engineered Barrier System (EBS) radionuclide transport abstraction model, as directed by a written development plan (CRWMS M&O 1999a). This abstraction is the conceptual model that will be used to determine the rate of release of radionuclides from the EBS to the unsaturated zone (UZ) in the total system performance assessment-license application (TSPA-LA). In particular, this model will be used to quantify the time-dependent radionuclide releases from a failed waste package (WP) and their subsequent transport through the EBS to the emplacement drift wall/UZ interface. The development of this conceptual model will allow Performance Assessment Operations (PAO) and its Engineered Barrier Performance Department to provide a more detailed and complete EBS flow and transport abstraction. The results from this conceptual model will allow PA0 to address portions of the key technical issues (KTIs) presented in three NRC Issue Resolution Status Reports (IRSRs): (1) the Evolution of the Near-Field Environment (ENFE), Revision 2 (NRC 1999a), (2) the Container Life and Source Term (CLST), Revision 2 (NRC 1999b), and (3) the Thermal Effects on Flow (TEF), Revision 1 (NRC 1998). The conceptual model for flow and transport in the EBS will be referred to as the ''EBS RT Abstraction'' in this analysis/modeling report (AMR). The scope of this abstraction and report is limited to flow and transport processes. More specifically, this AMR does not discuss elements of the TSPA-SR and TSPA-LA that relate to the EBS but are discussed in other AMRs. These elements include corrosion processes, radionuclide solubility limits, waste form dissolution rates and concentrations of colloidal particles that are generally represented as boundary conditions or input parameters for the EBS RT Abstraction. In effect, this AMR provides the algorithms for transporting radionuclides using the flow geometry and radionuclide concentrations

  20. Radiation hard avalanche photodiodes for CMS ECAL

    CERN Document Server

    Kuznetsov, A; Britvitch, A; Deiters, K; Egeland, R; Gilbert, B; Godinovic, N; Ingram, Q; Lester, E; Musienko, Y; Puljak, I; Renker, D; Reucroft, S; Rusack, R W; Sakhelashvili, T M; Singovsky, A V; Soric, I; Swain, J D

    2003-01-01

    The photo detectors of the CMS electromagnetic calorimeter have to operate in a rather hostile environment, in a strong magnetic field of 4T and under unprecedented radiation levels. Avalanche Photo Diodes (APDs) have been chosen to detect the scintillation light of the 62,000 lead tungstate crystals in the barrel part of the calorimeter. After a 6 year long R&D work Hamamatsu Photonics produces APDs with a structure that is basically radiation hard. Only a few percent of the delivered APDs are weak due to defects at the surface caused by dust particles in the production process. Since a reliability of 99.9% is required, a method to detect weak APDs before they are built into the detector had to be developed. The described screening method is a combination of **6**0Co irradiations and annealing under bias of all APDs and irradiations with hadrons on a sampling basis.

  1. A study of silicon sensor for ILD ECAL

    CERN Document Server

    Tomita, Tatsuhiko; Jeans, Daniel; Kamiya, Yoshio; Kawagoe, Kiyotomo; Komamiya, Sachio; Kozakai, Chihiro; Miyazaki, Yohei; Suehara, Taikan; Sudo, Yuji; Ueno, Hiraku; Yoshioka, Tamaki

    2014-01-01

    The International Large Detector (ILD) is a proposed detector for the International Linear Collider (ILC). It has been designed to achieve an excellent jet energy resolution by using Particle Flow Algorithms (PFA), which rely on the ability to separate nearby particles within jets. PFA requires calorimeters with high granularity. The ILD Electromagnetic Calorimeter (ECAL) is a sampling calorimeter with thirty tungsten absorber layers. The total thickness of this ECAL is about 24 X$_0$, and it has between 10 and 100 million channels to make high granularity. Silicon sensors are a candidate technology for the sensitive layers of this ECAL. Present prototypes of these sensors have 256 5.5$\\times$5.5 mm$^2$ pixels in an area of 9$\\times$9 cm$^2$.We have measured various properties of these prototype sensors: the leakage current, capacitance, and full depletion voltage. We have also examined the response to an infrared laser to understand the sensor's response at its edge and between pixel readout pads, as well th...

  2. EBS Radionuclide Transport Abstraction

    International Nuclear Information System (INIS)

    The purpose of this report is to develop and analyze the engineered barrier system (EBS) radionuclide transport abstraction model, consistent with Level I and Level II model validation, as identified in Technical Work Plan for: Near-Field Environment and Transport: Engineered Barrier System: Radionuclide Transport Abstraction Model Report Integration (BSC 2005 [DIRS 173617]). The EBS radionuclide transport abstraction (or EBS RT Abstraction) is the conceptual model used in the total system performance assessment (TSPA) to determine the rate of radionuclide releases from the EBS to the unsaturated zone (UZ). The EBS RT Abstraction conceptual model consists of two main components: a flow model and a transport model. Both models are developed mathematically from first principles in order to show explicitly what assumptions, simplifications, and approximations are incorporated into the models used in the TSPA. The flow model defines the pathways for water flow in the EBS and specifies how the flow rate is computed in each pathway. Input to this model includes the seepage flux into a drift. The seepage flux is potentially split by the drip shield, with some (or all) of the flux being diverted by the drip shield and some passing through breaches in the drip shield that might result from corrosion or seismic damage. The flux through drip shield breaches is potentially split by the waste package, with some (or all) of the flux being diverted by the waste package and some passing through waste package breaches that might result from corrosion or seismic damage. Neither the drip shield nor the waste package survives an igneous intrusion, so the flux splitting submodel is not used in the igneous scenario class. The flow model is validated in an independent model validation technical review. The drip shield and waste package flux splitting algorithms are developed and validated using experimental data. The transport model considers advective transport and diffusive transport

  3. EBS Radionuclide Transport Abstraction

    Energy Technology Data Exchange (ETDEWEB)

    J. Prouty

    2006-07-14

    The purpose of this report is to develop and analyze the engineered barrier system (EBS) radionuclide transport abstraction model, consistent with Level I and Level II model validation, as identified in Technical Work Plan for: Near-Field Environment and Transport: Engineered Barrier System: Radionuclide Transport Abstraction Model Report Integration (BSC 2005 [DIRS 173617]). The EBS radionuclide transport abstraction (or EBS RT Abstraction) is the conceptual model used in the total system performance assessment (TSPA) to determine the rate of radionuclide releases from the EBS to the unsaturated zone (UZ). The EBS RT Abstraction conceptual model consists of two main components: a flow model and a transport model. Both models are developed mathematically from first principles in order to show explicitly what assumptions, simplifications, and approximations are incorporated into the models used in the TSPA. The flow model defines the pathways for water flow in the EBS and specifies how the flow rate is computed in each pathway. Input to this model includes the seepage flux into a drift. The seepage flux is potentially split by the drip shield, with some (or all) of the flux being diverted by the drip shield and some passing through breaches in the drip shield that might result from corrosion or seismic damage. The flux through drip shield breaches is potentially split by the waste package, with some (or all) of the flux being diverted by the waste package and some passing through waste package breaches that might result from corrosion or seismic damage. Neither the drip shield nor the waste package survives an igneous intrusion, so the flux splitting submodel is not used in the igneous scenario class. The flow model is validated in an independent model validation technical review. The drip shield and waste package flux splitting algorithms are developed and validated using experimental data. The transport model considers advective transport and diffusive transport

  4. BUSINESS MODELS FOR EXTENDING OF 112 EMERGENCY CALL CENTER CAPABILITIES WITH E-CALL FUNCTION INSERTION

    Directory of Open Access Journals (Sweden)

    Pop Dragos Paul

    2010-12-01

    Full Text Available The present article concerns present status of implementation in Romania and Europe of eCall service and the proposed business models regarding eCall function implementation in Romania. eCall system is used for reliable transmission in case of crush between In Vehicle System and Public Service Answering Point, via the voice channel of cellular and Public Switched Telephone Network (PSTN. eCall service could be initiated automatically or manual the driver. All data presented in this article are part of researches made by authors in the Sectorial Contract Implementation study regarding eCall system, having as partners ITS Romania and Electronic Solution, with the Romanian Ministry of Communication and Information Technology as beneficiary.

  5. EBS Radionuclide Transport Abstraction

    Energy Technology Data Exchange (ETDEWEB)

    J.D. Schreiber

    2005-08-25

    The purpose of this report is to develop and analyze the engineered barrier system (EBS) radionuclide transport abstraction model, consistent with Level I and Level II model validation, as identified in ''Technical Work Plan for: Near-Field Environment and Transport: Engineered Barrier System: Radionuclide Transport Abstraction Model Report Integration'' (BSC 2005 [DIRS 173617]). The EBS radionuclide transport abstraction (or EBS RT Abstraction) is the conceptual model used in the total system performance assessment for the license application (TSPA-LA) to determine the rate of radionuclide releases from the EBS to the unsaturated zone (UZ). The EBS RT Abstraction conceptual model consists of two main components: a flow model and a transport model. Both models are developed mathematically from first principles in order to show explicitly what assumptions, simplifications, and approximations are incorporated into the models used in the TSPA-LA. The flow model defines the pathways for water flow in the EBS and specifies how the flow rate is computed in each pathway. Input to this model includes the seepage flux into a drift. The seepage flux is potentially split by the drip shield, with some (or all) of the flux being diverted by the drip shield and some passing through breaches in the drip shield that might result from corrosion or seismic damage. The flux through drip shield breaches is potentially split by the waste package, with some (or all) of the flux being diverted by the waste package and some passing through waste package breaches that might result from corrosion or seismic damage. Neither the drip shield nor the waste package survives an igneous intrusion, so the flux splitting submodel is not used in the igneous scenario class. The flow model is validated in an independent model validation technical review. The drip shield and waste package flux splitting algorithms are developed and validated using experimental data. The transport

  6. Characteristic study of silicon sensor for ILD ECAL

    CERN Document Server

    Takada, Shusuke; Kawagoe, Kiyotomo; Miyazaki, Yohei; Sudo, Yuji; Suehara, Taikan; Sumida, Hiroki; Tomita, Tatsuhiko; Ueno, Hiraku; Yoshioka, Tamaki

    2015-01-01

    Excellent jet energy measurement is important at the International Linear Collider (ILC) because most of interesting physics processes decay into multi-jet final states. We employ a particle flow method to reconstruct particles, hence International Large Detector (ILD) needs high spatial resolution which can separate each particle in jets. We study pixelized silicon sensors as active material of ILD Silicon electro- magnetic calorimeter (SiECAL). This paper reports studies of temperature and humidity dependence on dark current and response of laser injection.

  7. A Silicon-Tungsten ECal with Integrated Electronics

    Energy Technology Data Exchange (ETDEWEB)

    Frey, R.; /Oregon U.; Brau, James E.; /Oregon U.; Breidenbach, Martin; /SLAC; Freytag, D.; /SLAC; Haller, G.; /SLAC; Herbst, R.; /SLAC; Lander, R.; /UC, Davis; Nelson, Timothy Knight; /SLAC; Radeka, V.; /Brookhaven; Tripathi, M.; /UC, Davis

    2011-11-10

    We summarize recent R&D progress for a silicon-tungsten electromagnetic calorimeter (ECal) with integrated electronics, designed to meet the ILC physics requirements. A basic physics requirement for ILC detectors is that they provide excellent reconstruction of hadronic final states. This allows access to new physics which is complementary to the LHC. One statement for a requirement on jet reconstruction is that intermediate particles which decay into jets, such as W, Z, or top, can be identified and isolated. This places unprecedented requirements on 2-jet or 3-jet mass resolution, typically at the level of 3-5% using the PFA technique, which makes challenging demands on the calorimeters. The electromagnetic energy resolution is not expected to limit jet resolution using a PFA. However, particle separation - photon-photon and charged hadron-photon - is crucial. In addition, if one provides this kind of imaging calorimeter to meet the PFA needs, these same features will also be put to good use for reconstruction of specific tau decay modes (to enable final-state polarization measurement), to 'track' photons (even if originating from a vertex displaced from the interaction point), to track MIPS, and so forth. Figure 1 and Table 1 provide some context for our ECal design within the SiD detector concept, along with some main design parameters. More detail is included in the presentation.

  8. Precision electromagnetic calorimetry at the energy frontier: CMS ECAL at LHC Run 2

    CERN Document Server

    Massironi, Andrea

    2015-01-01

    The CMS electromagnetic calorimeter (ECAL) is a high-resolution, hermetic, and homogeneous calorimeter made of 75,848 scintillating lead tungstate crystals. After the successful quest for the Higgs boson, the CMS ECAL is at the forefront of precision measurements and the search for new physics in data from the LHC, which recently began producing collisions at the unprecedented energy of 13 TeV. The exceptional precision of the CMS ECAL, as well as its timing performance, are invaluable tools for the discovery of new physics at the LHC Run 2. The excellent performance of the ECAL relies on precise calibration maintained over time, despite severe irradiation conditions. A set of inter-calibration procedures using different physics channels is carried out at regular intervals to normalize the differences in crystal light transparency and photodetector response between channels, which can change due to accumulated radiation. In this talk we present new reconstruction algorithms and calibration strategies which ai...

  9. Precision electromagnetic calorimetry at the energy frontier: CMS ECAL at LHC Run 2

    CERN Document Server

    Massironi, Andrea

    2015-01-01

    The CMS electromagnetic calorimeter (ECAL) is a high-resolution, hermetic, and homogeneous calorimeter made of 75,848 scintillating lead tungstate crystals. Following the discovery of the Higgs boson, the CMS ECAL is at the forefront of precision measurements and the search for new physics in data from the LHC, which recently began producing collisions at the unprecedented energy of 13 TeV. The exceptional precision of the CMS ECAL, as well as its timing performance, are invaluable tools for the discovery of new physics at the LHC Run 2. The excellent performance of the ECAL relies on precise calibration maintained over time, despite severe irradiation conditions. A set of inter-calibration procedures using different physics channels is carried out at regular intervals to normalize the differences in crystal light transparency and photodetector response between channels, which can change due to accumulated radiation. In this talk we present new reconstruction algorithms and calibration strategies which aim to...

  10. CMS experiment: Adding the timing detector in front of the Ecal.

    CERN Document Server

    Swalim, Mohamed

    2016-01-01

    This report contains my work here as a summer student regarding plotting the energy resolution inside the Ecal crystal matrix before and after adding the new timing detectors using a GEANT4 simulation.

  11. Measurement of the CMS ECAL Performance with Z Dielectron Decay Events in 2012 Data

    OpenAIRE

    Lambert, Valere; Bornheim, A.; Spiropulu, M.

    2012-01-01

    The detection and measurements of the decay mode of the Higgs boson into two photons for the Compact Muon Solenoid experiment (CMS) is crucially dependent on the energy resolution of the Electromagnetic Calorimeter (ECAL) as the energy resolution of the detector dominates the mass resolution of the decay channel. The mass resolution of the ECAL detector is measured by reconstructing the Z peak from its decay channel into two electrons with an optimization of electron ID selections and measuri...

  12. Application of EB in Japan

    International Nuclear Information System (INIS)

    Radiation processing using electron beam (EB) facilities other than gamma-ray facilities in Japan is introduced. After briefly presented the features of EB compared with gamma ray, present status of EB application is described. Polymerized materials for use of wire, cable, radial tire, heat shrinkable tube, foam polyethylene, PTFE, battery separator, and adsorbent material are known to be resulting from cross-linking, decomposition, and graft polymerization reactions. Environmental preservation includes electron flue gas treatment in the coal- or oil-fired power plants, research for volatile organic compounds (VOC) and dioxins, as well as wastewater and sludge treatment. Finally activity of JAERI in the related fields is overviewed with the authors prospects for utilization of low energy EB with low cost for surface treatment and functional materials. (S. Ohno)

  13. SCT Barrel Assembly Complete

    CERN Multimedia

    L. Batchelor

    As reported in the April 2005 issue of the ATLAS eNews, the first of the four Semiconductor Tracker (SCT) barrels, complete with modules and services, arrived safely at CERN in January of 2005. In the months since January, the other three completed barrels arrived as well, and integration of the four barrels into the entire barrel assembly commenced at CERN, in the SR1 building on the ATLAS experimental site, in July. Assembly was completed on schedule in September, with the addition of the innermost layer to the 4-barrel assembly. Work is now underway to seal the barrel thermal enclosure. This is necessary in order to enclose the silicon tracker in a nitrogen atmosphere and provide it with faraday-cage protection, and is a delicate and complicated task: 352 silicon module powertapes, 352 readout-fibre bundles, and over 400 Detector Control System sensors must be carefully sealed into the thermal enclosure bulkhead. The team is currently verifying the integrity of the low mass cooling system, which must be d...

  14. Deposition of antimony telluride thin film by ECALE

    Institute of Scientific and Technical Information of China (English)

    GAO; Xianhui; YANG; Junyou; ZHU; Wen; HOU; Jie; BAO; Siqian; FAN; Xi'an; DUAN; Xingkai

    2006-01-01

    The process of Sb2Te3 thin film growth on the Pt substrate by electrochemical atomic layer epitaxy (ECALE) was studied. Cyclic voltammetric scanning was performed to analyze the electrochemical behavior of Te and Sb on the Pt substrate. Sb2Te3 film was formed using an automated flow deposition system by alternately depositing Te and Sb atomic layers for 400 circles. The deposited Sb2Te3 films were characterized by XRD, EDX, FTIR and FESEM observation. Sb2Te3 compound structure was confirmed by XRD pattern and agreed well with the results of EDX quantitative analysis and coulometric analysis. FESEM micrographs showed that the deposit was composed of fine nano particles with size of about 20 nm. FESEM image of the cross section showed that the deposited films were very smooth and dense with thickness of about 190 nm. The optical band gap of the deposited Sb2Te3 film was determined as 0.42 eV by FTIR spectroscopy, and it was blue shifted in comparison with that of the bulk Sb2Te3 single crystal due to its nanocrystalline microstructure.

  15. TRT Barrel milestones passed

    CERN Multimedia

    Ogren, H

    2004-01-01

    The barrel TRT detector passed three significant milestones this spring. The Barrel Support Structure (BSS) was completed and moved to the SR-1 building on February 24th. On March 12th the first module passed the quality assurance testing in Building 154 and was transported to the assembly site in the SR-1 building for barrel assembly. Then on April 21st the final production module that had been scanned at Hampton University was shipped to CERN. TRT Barrel Module Production The production of the full complement of barrel modules (96 plus 9 total spares) is now complete. This has been a five-year effort by Duke University, Hampton University, and Indiana University. Actual construction of the modules in the United States was completed in the first part of 2004. The production crews at each of the sites in the United States have now completed their missions. They are shown in the following pictures. Duke University: Production crew with the final completed module. Indiana University: Module producti...

  16. The MDT Barrel Organ

    CERN Multimedia

    Claudia Marcelloni de Oliveira

    Have you ever looked for an interesting use for the spare detector parts once the construction phase was finished? Henk Tiecke, with the help of Oscar van Petten and Marco Kraan, all from NIKHEF, came up with a great idea for leftover MDT tubes. They simply built a pipe organ! See the MDT Barrel Organ in action, as recorded during a party thrown on the occasion of the first shipment of MDT chambers from NIKHEF to CERN. Want to know more about the organ? Please contact Henk Tiecke. Henk Tiecke playing the MDT Barrel Organ.

  17. Barrelled locally convex spaces

    CERN Document Server

    Pérez Carreras, P

    1987-01-01

    This book is a systematic treatment of barrelled spaces, and of structures in which barrelledness conditions are significant. It is a fairly self-contained study of the structural theory of those spaces, concentrating on the basic phenomena in the theory, and presenting a variety of functional-analytic techniques.Beginning with some basic and important results in different branches of Analysis, the volume deals with Baire spaces, presents a variety of techniques, and gives the necessary definitions, exploring conditions on discs to ensure that they are absorbed by the barrels of the sp

  18. The calibration and electron energy reconstruction of the BGO ECAL of the DAMPE detector

    Science.gov (United States)

    Zhang, Zhiyong; Wang, Chi; Dong, Jianing; Wei, Yifeng; Wen, Sicheng; Zhang, Yunlong; Li, Zhiying; Feng, Changqing; Gao, Shanshan; Shen, ZhongTao; Zhang, Deliang; Zhang, Junbin; Wang, Qi; Ma, SiYuan; Yang, Di; Jiang, Di; Chen, Dengyi; Hu, Yiming; Huang, Guangshun; Wang, Xiaolian; Xu, Zizong; Liu, Shubin; An, Qi; Gong, Yizhong

    2016-11-01

    The DArk Matter Particle Explorer (DAMPE) is a space experiment designed to search for dark matter indirectly by measuring the spectra of photons, electrons, and positrons up to 10 TeV. The BGO electromagnetic calorimeter (ECAL) is its main sub-detector for energy measurement. In this paper, the instrumentation and development of the BGO ECAL is briefly described. The calibration on the ground, including the pedestal, minimum ionizing particle (MIP) peak, dynode ratio, and attenuation length with the cosmic rays and beam particles is discussed in detail. Also, the energy reconstruction results of the electrons from the beam test are presented.

  19. The calibration and electron energy reconstruction of the BGO ECAL of the DAMPE detector

    CERN Document Server

    Zhang, Zhiyong; Dong, Jianing; Wei, Yifeng; Wen, Sicheng; Zhang, Yunlong; Li, Zhiying; Feng, Changqing; Gao, Shanshan; Shen, ZhongTao; Zhang, Deliang; Zhang, Junbin; Wang, Qi; Ma, SiYuan; Yang, Di; Jiang, Di; Chen, Dengyi; Hu, Yiming; Huang, Guangshun; Wang, Xiaolian; Xu, Zizong; Liu, Shubin; An, Qi; Gong, Yizhong

    2016-01-01

    The DArk Matter Particle Explorer (DAMPE) is a space experiment designed to search for dark matter indirectly by measuring the spectra of photons, electrons, and positrons up to 10 TeV. The BGO electromagnetic calorimeter (ECAL) is its main sub-detector for energy measurement. In this paper, the instrumentation and development of the BGO ECAL is briefly described. The calibration on the ground, including the pedestal, minimum ionizing particle (MIP) peak, dynode ratio, and attenuation length with the cosmic rays and beam particles is discussed in detail. Also, the energy reconstruction results of the electrons from the beam test are presented.

  20. A crystal barrel

    CERN Multimedia

    2007-01-01

    The production of crystals for the barrel of the CMS electromagnetic calorimeter has been completed. This is an important milestone for the experiment, which received the last of its 62,960 crystals on 9 March. The members of the team responsible for the crystal acceptance testing at CERN display the last crystal for the CMS electromagnetic calorimeter barrel. From left to right: Igor Tarasov, Etiennette Auffray and Hervé Cornet.One of the six machines specially developed to measure 67 different parameters on each crystal. Igor Tarasov is seen inserting the last batch of crystals into the machine. The last of the 62,960 CMS barrel crystals arrived at CERN on 9 March. Once removed from its polystyrene protection, this delicate crystal, like thousands of its predecessors, will be inserted into the last of the 36 supermodules of the barrel electromagnetic calorimeter in a few days' time. This marks the end of an important chapter in an almost 15-year-long journey by the CMS crystals team, some of whose member...

  1. Thin Concrete Barrel Vault

    NARCIS (Netherlands)

    Kamerling, M.W.

    2013-01-01

    The paper presents the structural design of a thin barrel vault constructed with Fusée Ceramique infill elements. The load transfer is analyzed and validated. For the structure composed of Fusée Ceramique elements, steel and concrete the stresses are calculated and compared to the stresses given in

  2. EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms

    DEFF Research Database (Denmark)

    Schrøder, Jacob M; Larsen, Jesper; Komarova, Yulia;

    2011-01-01

    surrounded by vesicles. Further, GST pull-down assays, mass spectrometry and immunoprecipitation indicated that EB1 and EB3 interact with proteins implicated in MT minus-end anchoring or vesicular trafficking to the cilia base, suggesting that EB1 and EB3 promote ciliogenesis by facilitating such trafficking...

  3. Integration of CMS-ECAL supermodules : electronic components (VFE cards) and supermodule overview

    CERN Multimedia

    2004-01-01

    Each ECAL supermodule (composed by 1700 lead tungstate crystals) contains 68 motherboards, connected, via flexible kapton cables, to the photodetectors of 25 crystals each. Signals belonging to groups of five crystals are amplificated and digitized by Very Front End (VFE) cards. Signals from the sensor capsules are routed to the VFE cards for temperature monitoring thermistors.

  4. E-call, stav a vývoj systému

    OpenAIRE

    Vlček, Jiří

    2012-01-01

    This bachelor work describe passive safety system eCall, as part of the eSafety initiative. The work deal about system components, establishment, develepment and estimate the consequences of an accident. Finally, the work also describec the commnication between the passengers of a crasshed car and emergency center.

  5. ATLAS TRT barrel

    CERN Multimedia

    CERN Video Productions

    2005-01-01

    On 3 February 2005, members of the US-TRT team proceeded to the installation of the last TRT barrel module for the Transition Radiation Tracker, which will be used for tracking in the Atlas detector. The TRT barrel is made of 96 modules containing around 52 000 4-mm straws, each of them equipped with a 20 microns sense wire. The modules were first designed at CERN, then built in the USA between 1996 and 2003. Duke, Hampton and Indiana Universities, tested in details at CERN between 2003 and 2005 by members of the US-TRT group, and mounted on the support structure in the SR-1 building where this video was taken. During assembly of the last module, one can see Kirill Egorov (PNPI, Gatchina, Russia), Chuck Mahlong (Hampton) as well as John Callahan and Pauline Gagnon (Indiana). (Written by Pauline Gagnon)

  6. Paying by the Barrel

    Institute of Scientific and Technical Information of China (English)

    Francis L.Sackitey; Ghana

    2012-01-01

    CHINA'S UNIPEC Asia Co. Ltd. will buy up the entire oil share from Ghana's Jubilee field for the next 15 years in a commercial agreement entered into by the government of Ghana. Under the agreement, the West African nation will be supplying China with 13,000 barrels of crude oil daily to pay for a $3 billion loan granted to Ghana by China under a Master Facility Agreement with the China Development Bank.

  7. Weapons barrel life cycle determination

    Directory of Open Access Journals (Sweden)

    Nebojša Pene Hristov

    2013-10-01

    Full Text Available This article describes the dynamic processes within the gun barrel during the firing process in exploitation. It generally defines the basic principles of constructing tube elements, and shows the distortion of the basic geometry of the tube interior due to wear as well as the impact it causes during exploitation. The article also defines basic empirical models as well as a model based on fracture mechanics for the calculation of a use-life of the barrel, and other elements essential for the safe use of the barrel as the basic weapon element. Erosion causes are analysed in order to control and reduce wear and prolong the lifetime of the gun barrel. It gives directions for the reparation of barrels with wasted resources. In conclusion, the most influential elements of tube wear are given as well as possible modifications of existing systems, primarily propellant charges, with a purpose of prolonging lifetime of gun barrels. The guidelines for a proper determination of the lifetime based on the barrel condition assessment are given as well. INTRODUCTION The barrel as the basic element of each weapon is described as well as the processes occurring during the firing that have impulsive character and are accompanied by large amounts of energy. The basic elements of barrel and itheir constructive characteristics are descibed. The relation between Internal ballistics, ie calculation of the propellant gas pressure in the firing process, and structural elements defined by the barrel material resistance is shown. In general, this part of the study explains the methodology of the gun barrel structural elements calculation, ie. barrel geometry, taking into account the degrees of safety in accordance with Military Standards.   TUBE WEAR AND DEFORMATIONS The weapon barrel gradually wears out during exploitation due to which it no longer satisfies the set requirements. It is considered that the barrel has experienced a lifetime when it fails to fulfill the

  8. Double Screening Tests of the CMS ECAL Avalanche Photodiodes

    CERN Document Server

    Deiters, Konrad; Renker, Dieter; Sakhelashvili, Tariel; Britvitch, Ilia; Kuznetsov, Andrey; Musienko, Yuri; Singovsky, Alexander

    2005-01-01

    Specially developed avalanche photo-diodes (APDs) will be used to measure the light from the 61,200 lead tungstate crystals in the barrel part of the CMS electromagnetic calorimeter. To ensure the reliability over the lifetime of the detector, every APD is screened by irradiation and burn-in before it is accepted for CMS. As part of the establishment of the screening procedure and to determine its effectiveness, a large number of APDs were screened twice. The results of these tests suggest that the required reliability will be achieved.

  9. Precision electromagnetic calorimetry at the energy frontier The CMS ECAL at the LHC Run 2

    CERN Document Server

    AUTHOR|(CDS)2084425

    2015-01-01

    The Large Hadron Collider (LHC) has recently restarted operations (Run 2) with proton-proton collisions at an unprecedented centre-of-mass energy of 13 TeV and is moving to a reduced bunch spacing of 25 ns. After the successful quest for a Higgs boson via its electromagnetic decays, and the subsequent measurement of its mass, the CMS electromagnetic calorimeter (ECAL) plans to perform precision measurements and searches for new physics phenomena beyond the standard model with the data that are being collected. In this poster we present new reconstruction algorithms and calibration strategies that aim to maintain, and even improve, the excellent performance of the CMS ECAL under the new challenging experimental conditions. The CMS ECAL is a high-resolution, hermetic, and homogeneous electromagnetic calorimeter made of 75,848 scintillating lead tungstate crystals. Its resolution, as well as its timing performance, are valuable tools for the discovery of new physics with the CMS detector at the LHC. The performa...

  10. The PANDA Barrel DIRC

    Science.gov (United States)

    Dzhygadlo, R.; Schwarz, C.; Belias, A.; Gerhardt, A.; Götzen, K.; Kalicy, G.; Krebs, M.; Lehmann, D.; Nerling, F.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwiening, J.; Traxler, M.; Zühlsdorf, M.; Britting, A.; Eyrich, W.; Lehmann, A.; Pfaffinger, M.; Uhlig, F.; Düren, M.; Etzelmüller, E.; Föhl, K.; Hayrapetyan, A.; Kröck, B.; Merle, O.; Rieke, J.; Schmidt, M.; Cowie, E.; Keri, T.; Achenbach, P.; Cardinali, M.; Hoek, M.; Lauth, W.; Schlimme, S.; Sfienti, C.; Thiel, M.

    2016-05-01

    The PANDA detector at the international accelerator Facility for Antiproton and Ion Research in Europe (FAIR) addresses fundamental questions of hadron physics. Experiments concerning charmonium spectroscopy, the search for hybrids and glueballs and the interaction of hidden and open charm particles with nucleons and nuclei will be performed with antiproton beams impinging on hydrogen or nuclear targets. Cooled beams allow the precision scan of resonances in formation experiments. The momentum range of the antiproton beam between 1.5 GeV/c and 15 GeV/c tests predictions by perturbation theory and will reveal deviations originating from strong QCD . An excellent hadronic particle identification will be accomplished by DIRC (Detection of Internally Reflected Cherenkov light) counters. The design for the barrel region is based on the successful BaBar DIRC with several key improvements, such as fast photon timing and a compact imaging region. DIRC designs based on different radiator geometries with several focusing options were studied in simulation. The performance of each design was characterized in terms of photon yield and single photon Cherenkov angle resolution. Selected design options were implemented in prototypes and tested with hadronic particle beams at GSI and CERN.

  11. Barrel-shaped supernova remnants

    International Nuclear Information System (INIS)

    The authors argue that the majority of radio supernova remnants have a three-dimensional distribution of emissivity which is barrel shaped, with little emission from the end-caps. They examine some mechanisms which could produce this distribution

  12. The Electron Beam Semiconductor (EBS) amplifier

    Science.gov (United States)

    True, R. M.; Baxendale, J. F.

    1980-07-01

    The Electron Beam Semiconductor (EBS) concept has existed for three decades; but only within the last decade has an active, well-defined program been underway to develop devices that can operate as high-power radio frequency(RF) amplifiers, fast risetime switches, and current and voltage pulse amplifiers. This report discusses the test procedures, data and results of reliability testing of RF and video pulse EBS amplifiers at Electronics Research and Development Command (ERADCOM), Fort Monmouth, New Jersey. Also, the experimental analysis of the series connected diode EBS device is described in detail. Finally, the report concludes with a discussion of the state-of-the-art of EBS and future trends of the technology.

  13. Robustness of a SiECAL used in Particle Flow Reconstruction

    OpenAIRE

    Kozakai, Chihiro; Chen, Shion; Jeans, Daniel; Kamiya, Yoshio; Komamiya, Sachio

    2014-01-01

    The physics program of future lepton colliders such as the ILC, will benefit from a jet energy resolution in the range 3-4%. The International Large Detector (ILD) reaches this goal over a large range of jet energies. In this paper, we report on the dependence of the simulated ILD performance on various parameters of its silicon-tungsten ECAL. We investigate the effects of dead areas in the silicon sensors, the thickness of the PCB at the heart of the detector, and the robustness of its perfo...

  14. A Neutron Detector for the Electron Calorimeter (ECAL) Long Duration Balloon Experiment

    Science.gov (United States)

    Adams, J. H., Jr.; Bashindzhagyan, G. L.; Binns, W. R.; Chang, J.; Cherry, M. L.; Christl, M. J.; Guzik, t. G.; Isbert, J.; Israel, M. H.; Korotkova, N.; Panasyuk, M. I.; Panov, A.; Sokolskaya, N. V.; Watts, J. W.; Wefel, J. P.; Zatsepin, V.

    2007-01-01

    The highest energy measurements of cosmic ray electrons extend just beyond 1 TeV. High energy electrons are of particular interest because energy losses during interstellar propagation insure that they arrive primarily from nearby sources. This may produce observable structure in their spectrum. Further, it is predicted that electrons and positrons result from the annihilation of many exotic particles deposited as dark matter candidates. These electrons may appear as excesses in the cosmic ray electron spectrum from 200 GeV to 1000 GeV. A new long duration balloon experiment, ECAL, is being planned to provide direct cosmic ray electron measurements from approx.50 GeV to >1 TeV. To make these measurements ECAL must discriminate strongly against showers from protons and heavier ions. One of the techniques used to make this discrimination may be based on measuring the secondary neutrons produced by events in the instrument. The neutron detector configuration and technique will be discussed along with its expected performance based on Monte Carlo simulations.

  15. Trapping of normal EB1 ligands in aggresomes formed by an EB1 deletion mutant

    Directory of Open Access Journals (Sweden)

    Askham Jon M

    2005-04-01

    Full Text Available Abstract Background EB1 is a microtubule tip-associated protein that interacts with the APC tumour suppressor protein and the p150glued subunit of dynactin. We previously reported that an EB1 deletion mutant that retains both of these interactions but does not directly associate with microtubules (EB1-ΔN2-GFP spontaneously formed perinuclear aggregates when expressed in COS-7 cells. Results In the present study live imaging indicated that EB1-ΔN2-GFP aggregates underwent dynamic microtubule-dependent changes in morphology and appeared to be internally cohesive. EB1-ΔN2-GFP aggregates were phase-dense structures that displayed microtubule-dependent accumulation around the centrosome, were immunoreactive for both the 20s subunit of the proteasome and ubiquitin, and induced the collapse of the vimentin cytoskeleton. Fractionation studies revealed that a proportion of EB1-ΔN2-GFP was detergent-insoluble and ubiquitylated, indicating that EB1-ΔN2-GFP aggregates are aggresomes. Immunostaining also revealed that APC and p150glued were present in EB1-ΔN2-GFP aggregates, whereas EB3 was not. Furthermore, evidence for p150glued degradation was found in the insoluble fraction of EB1-ΔN2-GFP transfected cultures. Conclusion Our data indicate that aggresomes can be internally cohesive and may not represent a simple "aggregate of aggregates" assembled around the centrosome. Our observations also indicate that a partially misfolded protein may retain the ability to interact with its normal physiological ligands, leading to their co-assembly into aggresomes. This supports the idea that the trapping and degradation of co-aggregated proteins might contribute to human pathologies characterised by aggresome formation.

  16. UV/EB curing in Australia

    International Nuclear Information System (INIS)

    Progress in LTV/EB curing is reviewed in Australia. Generally the technology is used by those industries where curing is well developed in Europe and North America, however the scale is an order of magnitude lower due to the smaller market size. The Asian economic crisis does not appear to have affected expansion of the technology in Australia. EB continues to be successfully used in the packaging and foam fields whilst in UV, security devices, particularly banknotes are steadily expanding especially in export markets have been studied

  17. UV/EB curing market in Indonesia

    International Nuclear Information System (INIS)

    The most application of UV curing of surface coating in Indonesia are on fancy plywood, furniture and wood flooring industry. Other application are on papers, printing ink/labelling, printed circuit board/PCB and dental materials. At present, application of EB curing coating is still in a pilot plant scale due to the high cost of production. Limited number of application of EB curing by using low energy electron beam machine are on wood panels, ceramics and marbles. This paper describes the market and the problem faced by the largest user of radiation curing systems such as the secondary process plywood, furniture and paper industries

  18. ID Barrel installed in cryostat

    CERN Multimedia

    Apsimon, R.; Romaniouk, A.

    Wednesday 23rd August was a memorable day for the Inner Detector community as they witnessed the transport and installation of the central part of the inner detector (ID-barrel) into the ATLAS detector. Many members of the collaboration gathered to witness this moment at Point 1. After years of design, construction and commissioning, the outer two detectors (TRT and SCT) of the ID barrel were moved from the SR1 cleanroom to the ATLAS cavern. The barrel was moved across the car park from building 2175 to SX1. Although only a journey of about 100 metres, this required weeks of planning and some degree of luck as far as the weather was concerned. Accelerometers were fitted to the barrel to provide real-time monitoring and no values greater than 0.1 g were recorded, fully satisfying the transport specification for this extremely precise and fragile detector. Muriel, despite her fear of heights, bravely volunteered to keep a close eye on the detector. Swapping cranes to cross the entire parking lot, while Mur...

  19. EB Frond wave energy converter - phase 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    The EB Frond project is a wave energy programme developed by The Engineering Business (EB) from an original idea at Lancaster University. The EB Frond is a wave generator with a collector vane on top of an arm that pivots near the seabed. Phase 1 of the project demonstrated the technical feasibility of the project and provided proof of concept. Phase 2 involved further assesment of the technical and commercial viability of the concept through the development of mathematical and physical modelling methods. The work involved small-scale (1/25th) testing in wave tanks at Newcastle and Lancaster Universities and the development, verification and validation of a time domain mathematical model. The decision by EB to put on hold its renewable generation programme meant that plans to test at an intermediate scale (1/16th), assess different survival strategies in extreme wave conditions, carry out site characterisation for full-scale systems and to produce a robust economic model were not fulfilled. However, the mathematical and physical modelling work was used to develop an economic model for the Frond system. This produced a predicted unit cost of electricity by a pre-commercial 5 MW demonstration farm of about 17 pence/kWh. The report discusses the small-scale testing, test results, mathematical modelling, analysis and interpretation, survivability, the economic model and the development route to full-scale production.

  20. Silicon photomultiplier readout system for the ECAL in the PEBS and test results from the system

    Institute of Scientific and Technical Information of China (English)

    LI Liang; GONG Guang-Hua; ZENG Ming

    2011-01-01

    Silicon photomultipliers (SiPMs) have remarkable advantages for use in photo-detection.Compared with PMT,SiPM shows advantages of high gain,excellent time resolution,insensitivity to magnetic fields and a lower operating voltage.SiPMs from Hamamatsu are used in the electromagnetic calorimeter (ECAL)sub-detector in the Positron Electron Balloon Spectrometer (PEBS) experiment,a balloon-borne spectrometer experiment aiming at the precise measurement of the cosmic-ray positron fraction.This paper introduces the evaluation and test results of several SiPM detector types,the dedicated front-end application specific integrated circuit (ASIC) electronics and the design of the data acquisition system (DAQ) system.

  1. The Role of Microtubule End Binding (EB) Proteins in Ciliogenesis

    DEFF Research Database (Denmark)

    Schrøder, Jacob Morville

    EB1 is a small microtubule (MT)-binding protein that associates preferentially with MT plus ends. EB1 plays a role in regulating MT dynamics, localizing other MT-associated proteins to the plus end, and in regulating interactions of MTs with the cell cortex, mitotic kinetochores and different...... cellular organelles (Lansbergen and Akhmanova, 2006). EB1 also localizes to centrosomes and is required for centrosomal MT anchoring and organization of the MT network (Askham et al., 2002). Further, EB1 has been shown to localize to the flagellar tip and proximal region of the basal bodies......, are required for assembly of primary cilia in cultured human cells. The EB3 - siRNA ciliary phenotype could be rescued by GFP-EB1 expression, and GFP-EB3 over expression resulted in elongated cilia. Transmission electron microscopy (TEM) revealed that EB3-depleted cells possess stumpy cilia, a disorganized...

  2. The PANDA Barrel DIRC detector

    Energy Technology Data Exchange (ETDEWEB)

    Hoek, M., E-mail: matthias.hoek@uni-mainz.de [Institut für Kernphysik, Johannes Gutenberg University Mainz, Mainz (Germany); Dzhygadlo, R.; Gerhardt, A.; Götzen, K.; Hohler, R.; Kalicy, G.; Kumawat, H.; Lehmann, D.; Lewandowski, B.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Zühlsdorf, M. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Dodokhov, V. Kh. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Britting, A.; Eyrich, W. [Friedrich Alexander-University of Erlangen-Nuremberg, Erlangen (Germany); and others

    2014-12-01

    The PANDA experiment at the new Facility for Antiproton and Ion Research in Europe (FAIR) at GSI, Darmstadt, will study fundamental questions of hadron physics and QCD using high-intensity cooled antiproton beams with momenta between 1.5 and 15 GeV/c. Efficient Particle Identification for a wide momentum range and the full solid angle is required for reconstructing the various physics channels of the PANDA program. Hadronic Particle Identification in the barrel region of the detector will be provided by a DIRC counter. The design is based on the successful BABAR DIRC with important improvements, such as focusing optics and fast photon timing. Several of these improvements, including different radiator geometries and optics, were tested in particle beams at GSI and at CERN. The evolution of the conceptual design of the PANDA Barrel DIRC and the performance of complex prototypes in test beam campaigns will be discussed.

  3. Completion of the TRT Barrel

    CERN Multimedia

    Gagnon, P

    On February 3, the US-TRT team proudly completed the installation of the 96th barrel TRT module on its support structure in the SR building at CERN. This happy event came after many years of R&D initiated in the nineties by the TA1 team at CERN, followed by the construction of the modules in three American institutes (Duke, Hampton and Indiana Universities) from 1996 to 2003. In total, the 96 barrel modules contain 52544 kapton straws, each 4 mm in diameter and strung with a 30 micron gold-plated tungsten wire. Each wire was manually inserted, a feat in itself! The inner layer modules contain 329 straws, the middle layer modules have 520 straws and the outer layer, 793 straws. Thirty- two modules of each type form a full layer. Their special geometry was designed such as to leave no dead region. On average, a particle will cross 36 straws. Kirill Egorov, Chuck Mahlon and John Callahan inserted the last module in the Barrel Support Structure. After completion in the US, all modules were transferred...

  4. Factors influencing EB curing of epoxy matrix

    International Nuclear Information System (INIS)

    The effectiveness of electron beam (EB) curing of epoxy resins was found to be influenced by catalyst. In the presence of iodonium salt (diaryl iodonium hexafluoroantimonate, C3), the EB curing of epoxy resin is easier than in the presence of triaryl sulfonium hexafluoroantimonate (C1), or triaryl sulfonium hexafluorophosphate (C2), or iron arene containing cationic catalyst (Irgacure 261). The epoxy 616 (diglycidyl ether of bisphenol A) and 648 (diglycidyl ether of phenolic novolacs) can be cured by the above onium salts catalysts C1-C3. The epoxy with glycidyl amino epoxide group (such as AG 80; AFG 90) could not be cured by onium salts catalyst. The influence of irradiation dose, temperature and the effect of impurities on curing reaction were investigated

  5. Factors influencing EB curing of epoxy matrix

    Energy Technology Data Exchange (ETDEWEB)

    Li Fengmei E-mail: brc@bnu.edu.cn; Bao Jianwen; Chen Xiangbao; Bao Huaying; Wang Huiliang

    2002-03-01

    The effectiveness of electron beam (EB) curing of epoxy resins was found to be influenced by catalyst. In the presence of iodonium salt (diaryl iodonium hexafluoroantimonate, C3), the EB curing of epoxy resin is easier than in the presence of triaryl sulfonium hexafluoroantimonate (C1), or triaryl sulfonium hexafluorophosphate (C2), or iron arene containing cationic catalyst (Irgacure 261). The epoxy 616 (diglycidyl ether of bisphenol A) and 648 (diglycidyl ether of phenolic novolacs) can be cured by the above onium salts catalysts C1-C3. The epoxy with glycidyl amino epoxide group (such as AG 80; AFG 90) could not be cured by onium salts catalyst. The influence of irradiation dose, temperature and the effect of impurities on curing reaction were investigated.

  6. EB detoxification of liquid hazardous wastes

    International Nuclear Information System (INIS)

    In the work, an engineering approach to technical solutions, considering accelerated electron beams as radiation source, is carried out, in order to allow and evaluate an effective recovery of drinking water from highly chemically polluted groundwaters. In connection with different engineering technical and economic parameters (suitable doses, EB-machine type, plant features, etc.) and with reference to 1-100 ton/hr contaminated stream flowrate range (2-50 kGy as considered absorbed dose range), a specifically developed computer code was run. Analysis results, based on investment and functioning cost figures evaluated with reference to industrial plant management scenarios, are treatment unit costs showing a noticeable economic attractiveness of radiation EB-technologies in the field of considered applications

  7. EB detoxification of liquid hazardous wastes

    Energy Technology Data Exchange (ETDEWEB)

    Tata, A.; Giuliani, S. [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dip. Innovazione; Diaco, L. [Hitesys s.p.a., Aprilia, Rome (Italy)

    1996-07-01

    In the work, an engineering approach to technical solutions, considering accelerated electron beams as radiation source, is carried out, in order to allow and evaluate an effective recovery of drinking water from highly chemically polluted groundwaters. In connection with different engineering technical and economic parameters (suitable doses, EB-machine type, plant features, etc.) and with reference to 1-100 ton/hr contaminated stream flowrate range (2-50 kGy as considered absorbed dose range), a specifically developed computer code was run. Analysis results, based on investment and functioning cost figures evaluated with reference to industrial plant management scenarios, are treatment unit costs showing a noticeable economic attractiveness of radiation EB-technologies in the field of considered applications.

  8. Longevity of the CMS ECAL and scintillator-based options for electromagnetic calorimetry at HL-LHC

    CERN Document Server

    Li, Hengne

    2015-01-01

    The CMS lead tungstate (PbWO$_{4}$) electromagnetic calorimeter (ECAL) has successfully achieved its first goal, the Higgs discovery 2012. However, longevity studies show that part of the PbWO$_{4}$ ECAL does not maintain the required performance due to the radiation damaged incurred at the HL-LHC. The forward region of the detector will suffer the most from radiation damage, and the ECAL Endcaps (EE) will need to be replaced. A scintillator-based option for the EE replacement, Shashlik, is presented in the paper. The Shashlik EE is a sampling calorimeter. Tungsten absorber plates are interleaved with scintillator plates (LYSO or CeF$_3$), with quartz and wavelength-shifting (WLS) capillaries optically coupled to the scintillator plates for light output. The Shashlik EE maintains a high energy resolution, but compared to the current PbWO$_{4}$ EE, it is at least five times greater in radiation hardness and has a module size four times smaller allowing four times higher granularity laterally for pileup mitigat...

  9. The OPAL muon barrel detector

    Energy Technology Data Exchange (ETDEWEB)

    Akers, R.J. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Allison, J. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Ashton, P. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Bahan, G.A. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Baines, J.T.M. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Banks, J.N. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Barlow, R.J. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Barnett, S. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Beeston, C. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Chrin, J.T.M. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Clowes, S.G. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Davies, O.W. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Duerdoth, I.P. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Hinde, P.S. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Hughes-Jones, R.E. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Lafferty, G.D. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Loebinger, F.K. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Macbeth, A.A. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; McGowan, R.F. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Moss, M.W. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Murphy, P.G. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Nijjhar, B. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; O`Dowd, A.J.P. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Pawley, S.J. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Phillips, P.D. [Manchester Univ. (United Kingdom). Dept. of Phys. and Astron.; Richards, G.E.

    1995-04-21

    The barrel part of the OPAL muon detector consists of 110 drift chambers forming four layers outside the hadron absorber. Each chamber covers an area of 1.2 m by up to 10.4 m and has two cells with wires parallel to the beam and a drift distance of 297 mm. A detailed description of the design, construction, operation and performance of the sub-detector is given. The system has been operating successfully since the start of LEP in 1989. ((orig.)).

  10. TRT and SCT barrels merge

    CERN Multimedia

    Wells, P S

    2006-01-01

    The SCT barrel was inserted in the TRT on 17 February, just missing Valentine's day. This was a change of emphasis for the two detectors. In the preceeding months there had been a lot of focus on testing their performance. The TRT had been observing cosmic rays through several sectors of the barrel, and all the modules on each of the four layers of the SCT had been characterised prior to integration. In parallel, the engineering teams, lead by Marco Olcese, Andrea Catinaccio, Eric Perrin, Neil Dixon, Iourii Gusakov, Gerard Barbier and Takashi Kohriki, had been preparing for this critical operation. Figure 1: Neil Dixon and Marco Olcese verifying the final alignment The two detectors had to be painstakingly aligned to be concentric to within a millimetre. The SCT was held on a temporary cantilever stand, and the TRT in the ID trolley had to inch over it. Finally the weight of the SCT was transferred to the rails on the inside of the TRT itself. The SCT services actually protruded a little outside the oute...

  11. Mechanical Self-shrinkage of Artillery Barrels

    Directory of Open Access Journals (Sweden)

    Ioan Ciorba

    2012-09-01

    Full Text Available Objective of this paper is to define what self-shrink artillery barrel is. She is considered to be a compound barrel like as a thick-walled tube (k>2, in his wall being introduced a state of stress and strain using specific technological proceeds. This type of treatment is aimed to increase the artillery barrel load capacity and wear resistance in operation. The experimental part was realized using an industrial plant at Mechanical Factory of Resita. This part presents a comparative study between mechanical self-shrinkage on artillery head barrel, first using a mandrel and seconds a ball.

  12. EB1 is required for primary cilia assembly in fibroblasts

    DEFF Research Database (Denmark)

    Schrøder, Jacob M; Schneider, Linda; Christensen, Søren T;

    2007-01-01

    EB1 is a small microtubule (MT)-binding protein that associates preferentially with MT plus ends and plays a role in regulating MT dynamics. EB1 also targets other MT-associated proteins to the plus end and thereby regulates interactions of MTs with the cell cortex, mitotic kinetochores, and diff......EB1 is a small microtubule (MT)-binding protein that associates preferentially with MT plus ends and plays a role in regulating MT dynamics. EB1 also targets other MT-associated proteins to the plus end and thereby regulates interactions of MTs with the cell cortex, mitotic kinetochores......, and different cellular organelles [1, 2]. EB1 also localizes to centrosomes and is required for centrosomal MT anchoring and organization of the MT network [3, 4]. We previously showed that EB1 localizes to the flagellar tip and proximal region of the basal body in Chlamydomonas[5], but the function of EB1...... in the cilium/flagellum is unknown. We depleted EB1 from NIH3T3 fibroblasts by using siRNA and found that EB1 depletion causes a approximately 50% reduction in the efficiency of primary cilia assembly in serum-starved cells. Expression of dominant-negative EB1 also inhibited cilia formation, and expression...

  13. Recent results from Crystal Barrel

    CERN Document Server

    Doser, Michael

    2000-01-01

    The Crystal Barrel detector has collected data on antiproton annihilation on Hydrogen and Deuterium at rest and at momenta up to 1940 MeV/c, accumulating a total of 600 M events with the goal of studying meson spectroscopy and searching for non-qbarq states. This large amount of data has allowed high statistics studies of exclusive final states produced under various initial conditions. Comparisons between different initial and final states greatly constrain the interpretation of these data sets. In particular, the requirement of consistency between fits of 3-body final state Dalitz plots is a powerful tool in the search for non-standard model resonances [1]. More recently, the study of the same Dalitz plot produced from antiproton annihilation on liquid and gaseous hydrogen, on deuterium or on liquid hydrogen at different center-of-mass energies has extended this approach to higher mass resonances.

  14. Prototyping the PANDA Barrel DIRC

    Energy Technology Data Exchange (ETDEWEB)

    Schwarz, C., E-mail: C.Schwarz@gsi.de [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Kalicy, G.; Dzhygadlo, R.; Gerhardt, A.; Götzen, K.; Hohler, R.; Kumawat, H.; Lehmann, D.; Lewandowski, B.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwiening, J.; Traxler, M.; Zühlsdorf, M. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Dodokhov, V.Kh. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Britting, A.; Eyrich, W.; Lehmann, A. [Friedrich Alexander-University of Erlangen-Nuremberg, Erlangen (Germany); and others

    2014-12-01

    The design of the Barrel DIRC detector for the future PANDA experiment at FAIR contains several important improvements compared to the successful BABAR DIRC, such as focusing and fast timing. To test those improvements as well as other design options a prototype was build and successfully tested in 2012 with particle beams at CERN. The prototype comprises a radiator bar, focusing lens, mirror, and a prism shaped expansion volume made of synthetic fused silica. An array of micro-channel plate photomultiplier tubes measures the location and arrival time of the Cherenkov photons with sub-nanosecond resolution. The development of a fast reconstruction algorithm allowed to tune construction details of the detector setup with test beam data and Monte-Carlo simulations.

  15. RESISTANCE OF FIRE-HOSE BARRELS

    Directory of Open Access Journals (Sweden)

    I. V. Kachanov

    2010-01-01

    Full Text Available Values of hydraulic resistance of main fire-hose barrels are determined in the paper. Such approach has made it possible to obtain analytical dependencies between main parameters of fire jets with due account of hydraulic losses in fire-hose barrels.

  16. Study on the heat-resistant EB curing composites

    Energy Technology Data Exchange (ETDEWEB)

    Bao Jianwen; Li Yang [Institute of Aeronautical Materials, Beijing (China); Li Fengmei [Institute of Low Energy Nuclear Physics, Beijing Normal Univ., Beijing (China)

    2000-03-01

    There are many advantages in the EB-curing process of composites. Heat-resistant EB-curing composites could substitute for polyimide composites used in aeronautical engine. The effects of catalyst and dose on the cured resin were investigated. The heat-resistance of the resin cured by EB was evaluated by dynamic mechanical thermal analysis (DMTA). The experiment result shows that the mechanical property of the composites cured by EB could meet the needs of the aeronautical engine in 250degC. (author)

  17. Photospheric response to EB-like event

    CERN Document Server

    Danilovic, S; Barthol, P; Gandorfer, A; Gizon, L; Hirzberger, J; van Noort, T L Riethmüller M; Rodríguez, J Blanco; Iniesta, J C Del Toro; Suárez, D Orozco; Schmidt, W; Pillet, V Martínez; Knölker, M

    2016-01-01

    Ellerman Bombs are signatures of magnetic reconnection, which is an important physical process in the solar atmosphere. How and where they occur is a subject of debate. In this paper we analyse Sunrise/IMaX data together with 3D MHD simulations that aim to reproduce the exact scenario proposed for the formation of these features. Although the observed event seems to be more dynamic and violent than the simulated one, simulations clearly confirm the basic scenario for the production of EBs. The simulations also reveal the full complexity of the underlying process. The simulated observations show that the Fe I 525.02 nm line gives no information on the height where reconnection takes place. It can only give clues about the heating in the aftermath of the reconnection. The information on the magnetic field vector and velocity at this spatial resolution is, however, extremely valuable because it shows what numerical models miss and how they can be improved.

  18. Liquid Argon Barrel Cryostat Arrived

    CERN Multimedia

    Pailler, P

    Last week the first of three cryostats for the ATLAS liquid argon calorimeter arrived at CERN. It had travelled for 46 days over several thousand kilometers from Japan to CERN. During three years it has been fabricated by Kawasaki Heavy Industries Ltd. at Harima, close to Kobe, under contract from Brookhaven National Laboratory (BNL) of the U.S.. This cryostat consists of two concentric cylinders made of aluminium: the outer vacuum vessel with a diameter of 5.5 m and a length of 7 m, and the inner cold vessel which will contain the electromagnetic barrel calorimeter immersed in liquid argon. The total weight will be 270 tons including the detectors and the liquid argon. The cryostat is now located in building 180 where it will be equipped with 64 feed-throughs which serve for the passage of 122,880 electrical lines which will carry the signals of the calorimeter. After integration of the calorimeter, the solenoidal magnet of ATLAS will be integrated in the vacuum vessel. A final cold test of the cryostat inc...

  19. Celebrating the Barrel Toroid commissioning

    CERN Multimedia

    Peter Jenni

    ATLAS invited Funding Agency representatives and Laboratory Heads directly related to the funding and construction of the Barrel Toroid for a small ceremony on 13th December 2006 at Point 1, in order to mark the successful first full excitation of the BT (see last eNews). On that date, which was during the December CERN Council week, several of the Funding Agency Heads or their representatives could be present, representing CEA France, INFN Italy, BMBF Germany, Spain, Sweden, Switzerland, Russia, JINR Dubna and CERN. Speeches were delivered by the ATLAS spokesperson Peter Jenni thanking the Funding Partners in the name of the Collaboration, by Magnet Project Leader Herman ten Kate tracing the BT construction history, and by the CERN Director-General Robert Aymar congratulating all those who have contributed to the successful project. Herman ten Kate addressing the delegates. The text of the introductory address by Peter Jenni is reproduced here. "It is a great pleasure for me to welcome you all here...

  20. 47 CFR 27.1203 - EBS programming requirements.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false EBS programming requirements. 27.1203 Section 27.1203 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES....1203 EBS programming requirements. (a) Except as provided in paragraphs (b), (c), and (d) of...

  1. High performance railgun barrels for laboratory use

    Science.gov (United States)

    Bauer, David P.; Newman, Duane C.

    1993-01-01

    High performance low-cost, laboratory railgun barrels are now available, comprised of an inherently stiff containment structure which surrounds the bore components machined from 'off the-shelf' materials. The shape of the containment structure was selected to make the barrel inherently stiff. The structure consists of stainless steel laminations which do not compromise the electrical efficiency of the railgun. The modular design enhances the utility of the barrel, as it is easy to service between shots, and can be 're-cored' to produce different configurations and sizes using the same structure. We have produced barrels ranging from 15 mm to 90 mm square bore, a 30 mm round bore, and in lengths varying from 0.25 meters to 10 meters long. Successful tests with both plasma and solid metal armatures have demonstrated the versatility and performance of this design.

  2. Work on the ATLAS semiconductor tracker barrel

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    Precision work is performed on the semiconductor tracker barrel of the ATLAS experiment. All work on these delicate components must be performed in a clean room so that impurities in the air, such as dust, do not contaminate the detector. The semiconductor tracker will be mounted in the barrel close to the heart of the ATLAS experiment to detect the path of particles produced in proton-proton collisions.

  3. First SCT Barrel arrives at CERN

    CERN Document Server

    Apsimon, R

    Mid-January saw the arrival at CERN of Barrel #3, the first of four SCT barrels. The barrels are formed as low-mass cylinders of carbon fibre skins on a honeycomb carbon core. They are manufactured in industry and then have all the final precision supports added and the final geometric metrology carried out at Geneva University. Barrel #3, complete with its 384 silicon detector modules, arrived by road from Oxford University in England where the modules were mounted using a purpose-built robot. The modules had been selected from the output of all four barrel module building clusters (in Japan, Scandinavia, USA and the UK). Since Barrel #3 will be exposed to high radiation levels within the tracker volume, these modules, representing over half a million readout channels, have been extensively tested at their operational temperature of around -25 degrees Celcius and at voltages of up to 500V. The dangers of shipping such a fragile component of ATLAS were apparent to all and considerable attention was focused...

  4. The TileCal Barrel Test Assembly

    CERN Multimedia

    Leitner, R

    On 30th October, the mechanics test assembly of the central barrel of the ATLAS tile hadronic calorimeter was completed in building 185. It started on 23rd June and is the second wheel for the Tilecal completely assembled this year. The ATLAS engineers and technicians are quick: instead of the 27 weeks initially foreseen for assembling the central barrel of the tile hadronic calorimeter (Tilecal) in building 185, they inserted the last of the 64 modules on 30th October after only 19 weeks. In part, this was due to the experience gained in the dry run assembly of the first extended barrel, produced in Spain, in spring this year (see Bulletin 23/2003); however, the central barrel is twice as long - and twice as heavy. With a length of 6.4 metres, an outer diameter of 8.5 metres and an inner diameter of 4.5 metres, the object weight is 1300 tonnes. The whole barrel cylinder is supported by the stainless steel support structure weighing only 27 tons. The barrel also has to have the right shape: over the whole 8...

  5. Antiviral activity of the EB peptide against zoonotic poxviruses

    Directory of Open Access Journals (Sweden)

    Altmann Sharon E

    2012-01-01

    Full Text Available Abstract Background The EB peptide is a 20-mer that was previously shown to have broad spectrum in vitro activity against several unrelated viruses, including highly pathogenic avian influenza, herpes simplex virus type I, and vaccinia, the prototypic orthopoxvirus. To expand on this work, we evaluated EB for in vitro activity against the zoonotic orthopoxviruses cowpox and monkeypox and for in vivo activity in mice against vaccinia and cowpox. Findings In yield reduction assays, EB had an EC50 of 26.7 μM against cowpox and 4.4 μM against monkeypox. The EC50 for plaque reduction was 26.3 μM against cowpox and 48.6 μM against monkeypox. A scrambled peptide had no inhibitory activity against either virus. EB inhibited cowpox in vitro by disrupting virus entry, as evidenced by a reduction of the release of virus cores into the cytoplasm. Monkeypox was also inhibited in vitro by EB, but at the attachment stage of infection. EB showed protective activity in mice infected intranasally with vaccinia when co-administered with the virus, but had no effect when administered prophylactically one day prior to infection or therapeutically one day post-infection. EB had no in vivo activity against cowpox in mice. Conclusions While EB did demonstrate some in vivo efficacy against vaccinia in mice, the limited conditions under which it was effective against vaccinia and lack of activity against cowpox suggest EB may be more useful for studying orthopoxvirus entry and attachment in vitro than as a therapeutic against orthopoxviruses in vivo.

  6. EB1 is required for spindle symmetry in mammalian mitosis.

    Directory of Open Access Journals (Sweden)

    Anke Brüning-Richardson

    Full Text Available Most information about the roles of the adenomatous polyposis coli protein (APC and its binding partner EB1 in mitotic cells has come from siRNA studies. These suggest functions in chromosomal segregation and spindle positioning whose loss might contribute to tumourigenesis in cancers initiated by APC mutation. However, siRNA-based approaches have drawbacks associated with the time taken to achieve significant expression knockdown and the pleiotropic effects of EB1 and APC gene knockdown. Here we describe the effects of microinjecting APC- or EB1- specific monoclonal antibodies and a dominant-negative EB1 protein fragment into mammalian mitotic cells. The phenotypes observed were consistent with the roles proposed for EB1 and APC in chromosomal segregation in previous work. However, EB1 antibody injection also revealed two novel mitotic phenotypes, anaphase-specific cortical blebbing and asymmetric spindle pole movement. The daughters of microinjected cells displayed inequalities in microtubule content, with the greatest differences seen in the products of mitoses that showed the severest asymmetry in spindle pole movement. Daughters that inherited the least mobile pole contained the fewest microtubules, consistent with a role for EB1 in processes that promote equality of astral microtubule function at both poles in a spindle. We propose that these novel phenotypes represent APC-independent roles for EB1 in spindle pole function and the regulation of cortical contractility in the later stages of mitosis. Our work confirms that EB1 and APC have important mitotic roles, the loss of which could contribute to CIN in colorectal tumour cells.

  7. Studies on EB radiation effect on PA610

    Energy Technology Data Exchange (ETDEWEB)

    Yang Kebin; Zhang Huaming; Li Xiurong; Xiong Ruilin [Sichuan Forever Group Co. Ltd., China Academy of Engineering Physics, Miangany (China)

    2000-03-01

    Radiation effect of PA610 with polyfunctional monomer trially isocyanurate (TAIC) was studied, the results show that crosslinking effect of EB radiation on PA610 is obvious. After the PA610 samples were radiated by EB with dosage 75KGY, the physical characters of PA610 materials were greatly improved, especially their tensile strength being increased about 18% and their impact strength about 50%, but their water and oil absorption were decreased. So, EB radiation can enhance PA610 materials physical strength, resistance to solvents and water and increase their thermal-deformation temperature. (author)

  8. Logistics IT Construction Based on ebXML%基于ebXML的物流信息化建设

    Institute of Scientific and Technical Information of China (English)

    汪健

    2011-01-01

    The paper introduces the principle and characteristics of ebXML and, in connection with the current status of modern logistics enterprises in China, analyzes the issues in its application, with suggestions for improvement offered at the end.%通过介绍ebXML的工作原理及其特点,阐述了ebxML技术构建物流信息交换平台的优势,并结合我国现代物流企业的现状.分析在应用ebXML中存在的问题,进而提出了对策与建议.

  9. Uniformity Measurements Across the Area of the CMS ECAL Avalanche Photodiodes

    CERN Document Server

    Godinovic, Nikola; Soric, Ivica; Antunovic, Zeljko; Dzelalija, Mile; Deiters, Konrad; Ingram, Quentin; Renker, Dieter; Musienko, Yuri

    2004-01-01

    The photodetectors which will read out the scintillation light generated in the lead tungstate crystals in the barrel part of the CMS electromagnetic calorimeter are avalanche photodiodes (APDs). Scanning the APD's active area with a collimated light spot, the spatial uniformity of their quantum efficiency and gain has been measured at four different operating gains. Details of the APD surface structure are examined by scanning with a fine light spot. These details help to explain the difference between the bias voltage for a given gain when the full APD area is illuminated and when only the central part is illuminated.

  10. Cross-Calibration of Two Automatic Quality Control Systems for the CMS ECAL Crystals

    CERN Document Server

    Auffray, Etiennette; Chevenier, Guy; Lecoq, Paul; Perez-Prado, P; Schneegans, Marc; Sempere-Roldan, P

    2003-01-01

    The barrel part of the CMS electromagnetic calorimeter consists of about 60000 PWO crystals and will be assembled in two Regional Centers, nearby Rome and at CERN. Two automatic machines have been designed to check the crystal quality before assembly. The main crystal characteristics are compared to a set of specifications included in the contract with the crystal producers. The stability and intercalibration between the two is a fundamental issue, which has to be controlled during the whole construction phase. This paper describes the checks that were made in order to cross calibrate the measurements and to guarantee a proper selection of crystals for the detector.

  11. THE CONCEPT OF INTEGRATED ENGINEERING AND BUSINESS (EB EDUCATION SYSTEM

    Directory of Open Access Journals (Sweden)

    Michał Charlak

    2013-12-01

    Full Text Available In our approach to engineering and business education system an engineer is a man working as creator and user of technical products. We stress that the process of understanding and gaining knowledge of technical reality and creativity of engineers are the essential for EB concept . Next, we describe briefly three perspectives for building the system of innovative product origination as a basis for EB system: 1 designer’s perspective; 2 business perspective. 3 consumer perspective.

  12. Design, Performance, and Calibration of CMS Hadron-Barrel Calorimeter Wedges

    CERN Document Server

    Baiatian, G; Emeliantchik, Igor; Massolov, V; Shumeiko, Nikolai; Stefanovich, R; Damgov, Jordan; Dimitrov, Lubomir; Genchev, Vladimir; Piperov, Stefan; Vankov, Ivan; Litov, Leander; Bencze, Gyorgy; Vesztergombi, Gyorgy; Zálán, Peter; Bawa, Harinder Singh; Beri, Suman Bala; Bhatnagar, Vipin; Kaur, Manjit; Kohli, Jatinder Mohan; Kumar, Arun; Singh, Jas Bir; Acharya, Bannaje Sripathi; Banerjee, Sunanda; Banerjee, Sudeshna; Chendvankar, Sanjay; Dugad, Shashikant; Kalmani, Suresh Devendrappa; Katta, S; Mazumdar, Kajari; Mondal, Naba Kumar; Nagaraj, P; Patil, Mandakini Ravindra; Reddy, L; Satyanarayana, B; Sudhakar, Katta; Verma, Piyush; Paktinat, S; Golutvin, Igor; Kalagin, Vladimir; Kosarev, Ivan; Mescheryakov, G; Sergeyev, S; Smirnov, Vitaly; Volodko, Anton; Zarubin, Anatoli; Gavrilov, Vladimir; Gershtein, Yuri; Kaftanov, Vitali; Kisselevich, I; Kolossov, V; Krokhotin, Andrey; Kuleshov, Sergey; Litvintsev, Dmitri; Stolin, Viatcheslav; Ulyanov, A; Demianov, A; Gribushin, Andrey; Kodolova, Olga; Petrushanko, Sergey; Sarycheva, Ludmila; Vardanyan, Irina; Yershov, A; Abramov, Victor; Goncharov, Petr; Khmelnikov, Alexander; Korablev, Andrey; Korneev, Yury; Krinitsyn, Alexander; Kryshkin, V; Lukanin, Vladimir; Pikalov, Vladimir; Ryazanov, Anton; Talov, Vladimir; Turchanovich, L; Volkov, Alexey; Camporesi, Tiziano; De Visser, Theo; Vlassov, E; Aydin, Sezgin; Dumanoglu, Isa; Eskut, Eda; Kayis-Topaksu, A; Kuzucu-Polatoz, A; Onengüt, G; Ozdes-Koca, N; Cankocak, Kerem; Ozok, Ferhat; Serin-Zeyrek, M; Sever, Ramazan; Zeyrek, Mehmet; Gülmez, Erhan; Isiksal, Engin; Kaya, Mithat; Ozkorucuklu, Suat; Levchuk, Leonid; Sorokin, Pavel; Grinev, B; Lubinsky, V; Senchishin, V; Anderson, E Walter; Hauptman, John M; Elias, John E; Elvira, D; Freeman, Jim; Green, Dan; Lazic, Dragoslav; Los, Serguei; O'Dell, Vivian; Ronzhin, Anatoly; Suzuki, Ichiro; Vidal, Richard; Whitmore, Juliana; Antchev, Georgy; Hazen, Eric; Lawlor, C; Machado, Emanuel; Posch, C; Rohlf, James; Wu, Shouxiang; Adams, Mark Raymond; Burchesky, Kyle; Qiang, W; Abdullin, Salavat; Baden, Drew; Bard, Robert; Eno, Sarah Catherine; Grassi, Tullio; Jarvis, Chad; Kellogg, Richard G; Kunori, Shuichi; Skuja, Andris; Podrasky, V; Sanzeni, Christopher; Winn, Dave; Akgun, Ugur; Ayan, S; Duru, Firdevs; Merlo, Jean-Pierre; Mestvirishvili, Alexi; Miller, Michael; Norbeck, Edwin; Olson, Jonathan; Onel, Yasar; Schmidt, Ianos; Akchurin, Nural; Carrell, Kenneth Wayne; Gumu, K; Thomas, Ray; Baarmand, Marc M; Ralich, Robert; Vodopiyanov, Igor; Cushman, Priscilla; Heering, Arjan Hendrix; Sherwood, Brian; Cremaldi, Lucien Marcus; Reidy, Jim; Sanders, David A; Karmgard, Daniel John; Ruchti, Randy; Fisher, Wade Cameron; Mans, Jeremy; Tully, Christopher; De Barbaro, Pawel; Bodek, Arie; Budd, Howard; Chung, Yeon Sei; Haelen, T; Imboden, Matthias; Hagopian, Sharon; Hagopian, Vasken; Johnson, Kurtis F; Barnes, Virgil E; Laasanen, Alvin T; Pompos, Arnold

    2007-01-01

    Extensive measurements have been made with pions, electrons and muons on four production wedges of the Compact Muon Solenoid (CMS) hadron barrel (HB) calorimeter in the H2 beam line at CERN with particle momenta varying from 20 to 300 GeV/c. Data were taken both with and without a prototype electromagnetic lead tungstate crystal calorimeter (EB) in front of the hadron calorimeter. The time structure of the events was measured with the full chain of preproduction front-end electronics running at 34 MHz. Moving-wire radioactive source data were also collected for all scintillator layers in the HB. These measurements set the absolute calibration of the HB prior to first pp collisions to approximately 4%.

  13. Iron Blocks of CMS Magnet Barrel Yoke.

    CERN Multimedia

    2000-01-01

    On the occasion of presenting the CMS Award 2000 to Deggendorfer Werft und Eisenbau GmbH the delivered blocks were inspected at CERN Point 5. From left to right: H. Gerwig (CERN, CMS Magnet Barrel Yoke Coordinator), G. Waurick (CERN), F. Leher (DWE, Project Engineer) and W. Schuster (DWE, Project Manager).

  14. Celebration for the ATLAS Barrel Toroid magnet

    CERN Multimedia

    2007-01-01

    Representatives from Funding Agencies and Barrel Toroid Magnet Laboratories during the ceremony. From left to right: Jean Zinn-Justin (Head of DAPNIA/CEA/Saclay), CERN Director-General Robert Aymar, and Roberto Petronzio (President INFN).Allan Clark (DPNC University Geneva) and Enrique Fernandez (IFAE Barcelona) were among the guests visiting the ATLAS cavern. The barrel toroid is visible in the background. A celebration took place at Point 1 on 13 December to toast the recent powering-up of the ATLAS barrel toroid magnet to full field (Bulletin No. 47-48/06). About 70 guests were invited to attend, mainly composed of representatives from funding partners and key members of the laboratory management teams of the barrel toroid magnet, representing CEA France, INFN Italy, BMBF Germany, Spain, Sweden, Switzerland, Russia, JINR Dubna and CERN. An introductory speech by ATLAS spokesperson Peter Jenni the scene for evening. This was followed by the ATLAS magnet system project leader Herman Ten Kate's account of the...

  15. Last Few Metres for the Barrel Calorimeter

    CERN Multimedia

    Nyman, T.

    On Friday 4th November, the ATLAS Barrel Calorimeter was moved from its assembly point at the side of the ATLAS cavern to the centre of the toroidal magnet system. The detector was finally aligned, to the precision of within a millimetre, on Wednesday 9th November. The ATLAS installation team, led by Tommi Nyman, after having positioned the Barrel Calorimeter in its final location in the ATLAS experimental cavern UX15. The Barrel Calorimeter which will absorb and measure the energy of photons, electrons and hadrons at the core of the ATLAS detector is 8.6 meters in diameter, 6.8 meters long, and weighs over 1600 Tonnes. It consists of two concentric cylindrical detector elements. The innermost comprises aluminium pressure vessels containing the liquid argon electromagnetic calorimeter and the solenoid magnet. The outermost is an assembly of 64 hadron tile calorimeter sectors. Assembled 18 meters away from its final position, the Barrel Calorimeter was relocated with the help of a railway, which allows ...

  16. ATLAS Barrel Toroid magnet reached nominal field

    CERN Multimedia

    2006-01-01

     On 9 November the barrel toroid magnet reached its nominal field of 4 teslas, with an electrical current of 21 000 amperes (21 kA) passing through the eight superconducting coils as shown on this graph

  17. ATLAS semiconductor tracker installed into its barrel

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    The ATLAS silicon tracker is installed in the silicon tracker barrel. Absolute precision was required in this operation to ensure that the tracker was inserted without damage through minimal clearance. The installation was performed in a clean room on the CERN site so that no impurities in the air would contaminate the tracker's systems.

  18. EB-curing of coatings on wood composite boards

    International Nuclear Information System (INIS)

    The industrial radiation processing using low energy electron beam (EB) accelerators lower than 300 keV offers high speed, safe technologies for the chemical conversion of thin layer coatings. Because of the nonselective mode of initiating chain reaction polymerization involving free radicals in synthetic coating layers and suitable substrates, the EB curing of the coatings on woods and papers has particular advantage. Hungary decided to start an up-to-date EB line to process cement-bound (CB) wood chipboards with pigmented acrylic coatings. The CB wood chipboards contain more than 60 % of portland cement and up to 40 % of wood particles. They are produced as large boads of 6 - 16 mm thickness. In their fireproof character and other aspects, they are similar to asbestos-cement boards without containing carcinagenic asbestos, and are stable against moisture and atmospheric influences. EB-cured acrylate coating improved further those properties, and makes them valuable structural material. Oligomers and monomers as the main components of EB curable coatings, the irradiation with a Van de Graaff type electron accelerator of 2 MeV and the results are reported. The oligomers play the most important role in the formation of radiation curable coatings. (K.I.)

  19. The CMS Barrel Calorimeter Response to Particle Beams from 2 to 350 GeV/c

    CERN Document Server

    Abdullin, Salavat; Acharya, Bannaje Sripathi; Adam, Nadia; Adams, Mark Raymond; Adzic, Petar; Akchurin, Nural; Akgun, Ugur; Albayrak, Elif Asli; Alemany-Fernandez, Reyes; Almeida, Nuno; Anagnostou, Georgios; Andelin, Daniel; Anderson, E Walter; Anfreville, Marc; Anicin, Ivan; Antchev, Georgy; Antunovic, Zeljko; Arcidiacono, Roberta; Arenton, Michael Wayne; Auffray, Etiennette; Argiro, Stefano; Askew, Andrew; Atramentov, Oleksiy; Ayan, S; Arcidy, M; Aydin, Sezgin; Aziz, Tariq; Baarmand, Marc M; Babich, Kanstantsin; Baccaro, Stefania; Baden, Drew; Baffioni, Stephanie; Bakirci, Mustafa Numan; Balazs, Michael; Banerjee, Sunanda; Banerjee, Sudeshna; Bard, Robert; Barge, Derek; Barnes, Virgil E; Barney, David; Barone, Luciano; Bartoloni, Alessandro; Baty, Clement; Bawa, Harinder Singh; Baiatian, G; Bandurin, Dmitry; Beauceron, Stephanie; Bell, Ken W; Bencze, Gyorgy; Benetta, Robert; Bercher, Michel; Beri, Suman Bala; Bernet, Colin; Berntzon, Lisa; Berthon, Ursula; Besançon, Marc; Betev, Botjo; Beuselinck, Raymond; Bhatnagar, Vipin; Bhatti, Anwar; Biino, Cristina; Blaha, Jan; Bloch, Philippe; Blyth, Simon; Bodek, Arie; Bornheim, Adolf; Bose, Suvadeep; Bose, Tulika; Bourotte, Jean; Brett, Angela Mary; Brown, Robert M; Britton, David; Budd, Howard; Bühler, M; Burchesky, Kyle; Busson, Philippe; Camanzi, Barbara; Camporesi, Tiziano; Cankocak, Kerem; Carrell, Kenneth Wayne; Carrera, E; Cartiglia, Nicolo; Cavallari, Francesca; Cerci, Salim; Cerutti, cM; Chang, Paoti; Chang, You-Hao; Charlot, Claude; Chen, E Augustine; Chen, Wan-Ting; Chen, Zheng-Yu; Chendvankar, Sanjay; Chipaux, Rémi; Choudhary, Brajesh C; Choudhury, Rajani Kant; Chung, Yeon Sei; Clarida, Warren; Cockerill, David J A; Combaret, Christophe; Conetti, Sergio; Cossutti, Fabio; Cox, Bradley; Cremaldi, Lucien Marcus; Cushman, Priscilla; Cussans, David; Dafinei, Ioan; Damgov, Jordan; Da Silva Di Calafiori, Diogo Raphael; Daskalakis, Georgios; Davatz, Giovanna; David, A; De Barbaro, Pawel; Debbins, Paul; Deiters, Konrad; Dejardin, Marc; Djordjevic, Milos; Deliomeroglu, Mehmet; Della Negra, Rodolphe; Della Ricca, Giuseppe; Del Re, Daniele; Demianov, A; De Min, Alberto; Denegri, Daniel; Depasse, Pierre; de Visser, Theo; Descamps, Julien; Deshpande, Pandurang Vishnu; Díaz, Jonathan; Diemoz, Marcella; Di Marco, Emanuele; Dimitrov, Lubomir; Dissertori, Günther; Dittmar, Michael; Djambazov, Lubomir; Dobrzynski, Ludwik; Drndarevic, Snezana; Duboscq, Jean Etienne; Dugad, Shashikant; Dumanoglu, Isa; Duru, Firdevs; Dutta, Dipanwita; Dzelalija, Mile; Efthymiopoulos, I; Elias, John E; Peisert, A; El-Mamouni, H; Elvira, D; Emeliantchik, Igor; Eno, Sarah Catherine; Ershov, Alexander; Erturk, Sefa; Esen, Selda; Eskut, Eda; Evangelou, Ioannis; Evans, David; Fabbro, Bernard; Faure, Jean-Louis; Fay, Jean; Fenyvesi, Andras; Ferri, Federico; Fisher, Wade Cameron; Flower, Paul S; Franci, Daniele; Franzoni, Giovanni; Freeman, Jim; Freudenreich, Klaus; Funk, Wolfgang; Ganjour, Serguei; Gargiulo, Corrado; Gascon, Susan; Gataullin, Marat; Gaultney, Vanessa; Gamsizkan, Halil; Gavrilov, Vladimir; Geerebaert, Yannick; Genchev, Vladimir; Gentit, François-Xavier; Gerbaudo, Davide; Gershtein, Yuri; Ghezzi, Alessio; Ghodgaonkar, Manohar; Gilly, Jean; Givernaud, Alain; Gleyzer, Sergei V; Gninenko, Sergei; Go, Apollo; Gobbo, Benigno; Godinovic, Nikola; Golubev, Nikolai; Golutvin, Igor; Goncharov, Petr; Gong, Datao; Govoni, Pietro; Grant, Nicholas; Gras, Philippe; Grassi, Tullio; Green, Dan; Greenhalgh, R J S; Gribushin, Andrey; Grinev, B; Guevara Riveros, Luz; Guillaud, Jean-Paul; Gurtu, Atul; Murat Guler, A; Gülmez, Erhan; Gümüs, K; Haelen, T; Hagopian, Sharon; Hagopian, Vasken; Haguenauer, Maurice; Halyo, Valerie; Hamel de Monchenault, Gautier; Hansen, Sten; Hashemi, Majid; Hauptman, John M; Hazen, Eric; Heath, Helen F; Heering, Arjan Hendrix; Heister, Arno; Heltsley, Brian; Hill, Jack; Hintz, Wieland; Hirosky, Robert; Hobson, Peter R; Honma, Alan; Hou, George Wei-Shu; Hsiung, Yee; Hunt, Adam; Husejko, Michal; Ille, Bernard; Ilyina, N; Imlay, Richard; Ingram, D; Ingram, Quentin; Isiksal, Engin; Jarry, Patrick; Jarvis, Chad; Jeong, Chiyoung; Jessop, Colin; Johnson, Kurtis F; Jones, John; Jovanovic, Dragoslav; Kaadze, Ketino; Kachanov, Vassili; Kaftanova, V; Kailas, Swaminathan; Kalagin, Vladimir; Kalinin, Alexey; Kalmani, Suresh Devendrappa; Karmgard, Daniel John; Kataria, Sushil Kumar; Kaur, Manjit; Kaya, Mithat; Kaya, Ozlem; Kayis-Topaksu, A; Kellogg, Richard G; Kennedy, Bruce W; Khmelnikov, Alexander; Kim, Heejong; Kisselevich, I; Kloukinas, Kostas; Kodolova, Olga; Kohli, Jatinder Mohan; Kokkas, Panagiotis; Kolberg, Ted; Kolossov, V; Korablev, Andrey; Korneev, Yury; Kosarev, Ivan; Kramer, Laird; Krasnikov, Nikolai; Krinitsyn, Alexander; Krokhotin, Andrey; Krpic, Dragomir; Kryshkin, V; Kubota, Yuichi; Kubrik, A; Kuleshov, Sergey; Kumar, Arun; Kumar, P; Kunori, Shuichi; Kuo, Chen-Cheng; Kurt, Pelin; Kyberd, Paul; Kyriakis, Aristotelis; Laasanen, Alvin T; Ladygin, Vladimir; Laird, Edward; Landsberg, Greg; Laszlo, Andras; Lawlor, C; Lazic, Dragoslav; Lebeau, Michel; Lecomte, Pierre; Lecoq, Paul; Ledovskoy, Alexander; Lee, Sang Joon; Leshev, Georgi; Lethuillier, Morgan; Levchuk, Leonid; Lin, Sheng-Wen; Lin, Willis; Linn, Stephan; Lintern, A L; Litvine, Vladimir; Litvintsev, Dmitri; Litov, Leander; Lobolo, L; Locci, Elizabeth; Lodge, Anthony B; Longo, Egidio; Loukas, Demetrios; Los, Serguei; Lubinsky, V; Luckey, Paul David; Lukanin, Vladimir; Lustermann, Werner; Lynch, Clare; Ma, Yousi; Machado, Emanuel; Mahlke-Krüger, H; Maity, Manas; Majumder, Gobinda; Malberti, Martina; Malclès, Julie; Maletic, Dimitrije; Mandjavidze, Irakli; Mans, Jeremy; Manthos, Nikolaos; Maravin, Yurii; Marchica, Carmelo; Marinelli, Nancy; Markou, Athanasios; Markou, Christos; Marlow, Daniel; Markowitz, Pete; Marone, Matteo; Martínez, German; Mathez, Hervé; Matveev, Viktor; Mavrommatis, Charalampos; Maurelli, Georges; Mazumdar, Kajari; Meridiani, Paolo; Merlo, Jean-Pierre; Mermerkaya, Hamit; Mescheryakov, G; Mestvirishvili, Alexi; Mikhailin, V; Milenovic, Predrag; Miller, Michael; Milleret, Gérard; Miné, Philippe; Möller, A; Mohammadi-Najafabadi, M; Mohanty, Ajit Kumar; Moissenz, P; Mondal, Naba Kumar; Moortgat, Filip; Mossolov, Vladimir; Mur, Michel; Musella, Pasquale; Musienko, Yuri; Nagaraj, P; Nardulli, Alessandro; Nash, Jordan; Nédélec, Patrick; Negri, Pietro; Newman, Harvey B; Nikitenko, Alexander; Norbeck, Edwin; Nessi-Tedaldi, Francesca; Obertino, Maria Margherita; Olson, Jonathan; Onel, Yasar; Onengüt, G; Organtini, Giovanni; Orimoto, Toyoko; Ozkan, Cigdem; Ozkurt, Halil; Ozkorucuklu, Suat; Ozok, Ferhat; Paganoni, Marco; Paganini, Pascal; Paktinat, S; Pal, Andras; Palma, Alessandro; Panev, Bozhidar; Pant, Lalit Mohan; Papadakis, Antonakis; Papadakis, Ioannis; Papadopoulos, Ioannis; Paramatti, Riccardo; Parracho, P; Pastrone, Nadia; Patil, Mandakini Ravindra; Patterson, Juliet Ritchie; Pauss, Felicitas; Penzo, Aldo; Petrakou, Eleni; Petrushanko, Sergey; Petrosian, A; Phillips II, David; Pikalov, Vladimir; Piperov, Stefan; Piroué, Pierre; Podrasky, V; Polatoz, A; Pompos, Arnold; Popescu, Sorina; Posch, C; Pozdnyakov, Andrey; Ptochos, Fotios; Puljak, Ivica; Pullia, Antonino; Punz, Thomas; Puzovic, Jovan; Qian, Weiming; Ragazzi, Stefano; Rahatlou, Shahram; Ralich, Robert; Rande, J; Razis, Panos A; Redaelli, Nicola; Reddy, L; Reidy, Jim; Renker, Dieter; Reucroft, Steve; Reymond, Jean-Marc; Ribeiro, Pedro Quinaz; Röser, Ulf; Rogalev, Evgueni; Rogan, Christopher; Roh, Youn; Rohlf, James; Romanteau, Thierry; Rondeaux, Françoise; Ronquest, Michael; Ronzhin, Anatoly; Rosowsky, André; Rovelli, Chiara; Ruchti, Randy; Rumerio, Paolo; Rusack, Roger; Rusakov, Sergey V; Ryan, Matthew John; Ryazanov, Anton; Safronov, Grigory; Sala, Leonardo; Salerno, Roberto; Sanders, David A; Santanastasio, Francesco; Sanzeni, Christopher; Sarycheva, Ludmila; Satyanarayana, B; Schinzel, Dietrich; Schmidt, Ianos; Seez, Christopher; Sekmen, Sezen; Semenov, Sergey; Senchishin, V; Sergeyev, S; Serin, Meltem; Sever, Ramazan; Sharp, Peter; Shepherd-Themistocleous, Claire; Siamitros, Christos; Sillou, Daniel; Singh, Jas Bir; Singovsky, Alexander; Sirois, Yves; Sirunyan, Albert M; Silva, J; Silva, Pedro; Skuja, Andris; Sharma, Seema; Sherwood, Brian; Shiu, Jing-Ge; Shivpuri, Ram Krishen; Shukla, Prashant; Shumeiko, Nikolai; Smirnov, Vitaly; Smith, Brian; Smith, Vincent J; Sogut, Kenan; Sonmez, Nasuf; Sorokin, Pavel; Spezziga, Mario; Sproston, Martin; Stefanovich, R; Stockli, F; Stolin, Viatcheslav; Sudhakar, Katta; Sulak, Lawrence; Suter, Henry; Suzuki, Ichiro; Swain, John; Tabarellide Fatis, T; Talov, Vladimir; Takahashi, Maiko; Tcheremoukhine, Alexandre; Teller, Olivier; Teplov, Konstantin; Theofilatos, Konstantinos; Thiebaux, Christophe; Thomas, Ray; Timciuc, Vladlen; Timlin, Claire; Titov, Maksym; Tobias, A; Tonwar, Suresh C; Topakli, Huseyin; Topkar, Anita; Triantis, Frixos A; Troshin, Sergey; Tully, Christopher; Turchanovich, L; Tyurin, Nikolay; Ueno, Koji; Ulyanov, A; Uzunian, Andrey; Vanini, A; Vankov, Ivan; Vardanyan, Irina; Varela, F; Varela, Joao; Vasil ev, A; Velasco, Mayda; Vergili, Mehmet; Verma, Piyush; Verrecchia, Patrice; Vesztergombi, Gyorgy; Veverka, Jan; Vichoudis, Paschalis; Vidal, Richard; Virdee, Tejinder; Vishnevskiy, Alexander; Vlassov, E; Vodopiyanov, Igor; Volobouev, Igor; Volkov, Alexey; Volodko, Anton; Von Gunten, Hans Peter; Wang, Lei; Wang, Minzu; Wardrope, David; Weber, Markus; Weng, Joanna; Werner, Jeremy Scott; Wetstein, Matthew; Winn, Dave; Wigmans, Richard; Williams, Jennifer C; Whitmore, Juliana; Won, Steven; Wu, Shouxiang; Yang, Yong; Yaselli, Ignacio; Yazgan, Efe; Yetkin, Taylan; Yohay, Rachel; Zabi, Alexandre; Zálán, Peter; Zamiatin, Nikolai; Zarubin, Anatoli; Zelepoukine, Serguei; Zeyrek, Mehmet; Zhang, Jia-Wen; Zhang, Lin; Zhu, Kejun; Zhu, Ren-Yuan

    2008-01-01

    The response of the CMS barrel calorimeter (electromagnetic plus hadronic) to hadrons, electrons and muons over a wide momentum range from 2 to 350 GeV/c has been measured. To our knowledge, this is the widest range of momenta in which any calorimeter system has been studied. These tests, carried out at the H2 beam-line at CERN, provide a wealth of information, especially at low energies. The analysis of the differences in calorimeter response to charged pions, kaons, protons and antiprotons and a detailed discussion of the underlying phenomena are presented. We also show techniques that apply corrections to the signals from the considerably different electromagnetic (EB) and hadronic (HB) barrel calorimeters in reconstructing the energies of hadrons. Above 5 GeV/c, these corrections improve the energy resolution of the combined system where the stochastic term equals 84.7$\\pm$1.6$\\%$ and the constant term is 7.4$\\pm$0.8$\\%$. The corrected mean response remains constant within 1.3$\\%$ rms.

  20. The chemistry of UV and EB radiation curing

    International Nuclear Information System (INIS)

    The application of photopolymerisation (UV) and electron beam (EB) technologies in radiation rapid cure (RRC) processing is discussed. The chemistry associated with such reactions and the mechanisms of the processes are treated. The occurrence of concurrent grafting to substrate with radiation curing of film is shown to be an advantage in enhancing the properties of certain finished products. The parameters influencing the optimum grafting yield in such RRC processes are discussed. In many applications, the chemistry of the process combined with the machine, expecially for EB, is shown a so-called ''turn-key'' operation. (author)

  1. Barrel calorimeter of the CMD-3 detector

    Energy Technology Data Exchange (ETDEWEB)

    Shebalin, V. E., E-mail: V.E.Shebalin@inp.nsk.su; Anisenkov, A. V.; Aulchenko, V. M.; Bashtovoy, N. S. [Russian Academy of Sciences, Budker Institute of Nuclear Physics, Siberian Branch (Russian Federation); Epifanov, D. A. [University of Tokyo, Department of Physics (Japan); Epshteyn, L. B.; Grebenuk, A. A.; Ignatov, F. V.; Erofeev, A. L.; Kovalenko, O. A.; Kozyrev, A. N.; Kuzmin, A. S.; Logashenko, I. B.; Mikhailov, K. Yu.; Razuvaev, G. P.; Ruban, A. A.; Shwartz, B. A.; Talyshev, A. A.; Titov, V. M.; Yudin, Yu. V. [Russian Academy of Sciences, Budker Institute of Nuclear Physics, Siberian Branch (Russian Federation)

    2015-12-15

    The structure of the barrel calorimeter of the CMD-3 detector is presented in this work. The procedure of energy calibration of the calorimeter and the method of photon energy restoration are described. The distinctive feature of this barrel calorimeter is its combined structure; it is composed of two coaxial subsystems: a liquid xenon calorimeter and a crystalline CsI calorimeter. The calorimeter spatial resolution of the photon conversion point is about 2 mm, which corresponds to an angular resolution of ∼6 mrad. The energy resolution of the calorimeter is about 8% for photons with energy of 200 MeV and 4% for photons with energy of 1 GeV.

  2. Technical Diagnostics of Tank Cannon Smooth Barrel Bore and Ramming Device

    OpenAIRE

    Jiri Balla; Stanislav Prochazka; Robert Jankovych; Stanislav Beer; Zbynek Krist; Michal Kovarik

    2015-01-01

    The technical diagnostics of 125 mm tank cannon 2A46 smooth barrel and ramming devices are discussed respectively. Focuses on barrel diagnostics and suggests new procedures based on reconstructed BG20 Gun Barrel Bore Gauge System, measuring internal diameter of the barrel bore. The new system measures throughout the whole barrel bore the inner diameter not only at the beginning of barrel bore as it was usually measured before. Different nature of barrel wear was revealed between barrels firin...

  3. Leading at the Front: How EB Proteins Regulate Microtubule Dynamics

    Science.gov (United States)

    Hawkins, Taviare

    2012-02-01

    Microtubules are the most rigid of the cytoskeletal filaments, they provide the cell's scaffolding, form the byways on which motor proteins transport intracellular cargo and reorganize to form the mitotic spindle when the cell needs to divide. These biopolymers are composed of alpha and beta tubulin monomers that create hollow cylindrical nanotubes with an outer diameter of 25 nm and an inner diameter of 17 nm. At steady state concentrations, microtubules undergo a process known as dynamic instability. During dynamic instability the length of individual microtubules is changing as the filament alternates between periods of growth to shrinkage (catastrophe) and shrinkage to growth (rescue). This process can be enhanced or diminished with the addition of microtubule associated proteins (MAPs). MAPs are microtubule binding proteins that stabilize, destabilize, or nucleate microtubules. We will discuss the effects of the stabilizing end-binding proteins (EB1, EB2 and EB3), on microtubule dynamics observed in vitro. The EBs are a unique family of MAPs known to tip track and enhance microtubule growth by stabilizing the ends. This is a different mechanism than those employed by structural MAPs such as tau or MAP4.

  4. Identification of positrons and electrons in the cosmic radiation with the electromagnetic calorimeter ECAL for the AMS-02 experiment

    CERN Document Server

    AUTHOR|(CDS)2080883

    2011-07-19

    In May 2011 AMS-02 detector has been successfully installed on the International Space Station (ISS), where it will take data on cosmic radiation from 1 to 1000 GeV for at least 10 years. Among all scientific objectives of the experiment, one of the most important is the search for Dark Matter (DM), which constitutes 80% of the Universe matter, but its nature is still unknown. A DM signal can be identified by studying the combined fluxes of positrons, photons, antiprotons and antideuterium. Thanks to its high acceptance and its performances, AMS-02 detector can extend primary cosmic ray physics search to a new energy range with high accuracy. A key role for these measurements, in particular for the electromagnetic channels, is played by ECAL calorimeter. This subdetector has been developed to measure e− and e+ energy with an accuracy of few %. Thanks to its 3D shower reconstruction imaging capabilities, it also has a high separation power between electromagnetic and hadronic showers (e/p rejection), essent...

  5. Application of calorimeters for 5 MeV EB and bremsstrahlung dosimetry

    DEFF Research Database (Denmark)

    Sato, T.; Takahashi, T.; Saito, T.;

    1993-01-01

    Graphite and water calorimeters, which were developed for use a 10 MeV electron beams (EB) at Riso National Laboratory, were used for process validation and routine dosimeter calibration at a 5 MeV EB. Water calorimeters were used for reference measurements for 5 MeV EB, the response was found...... at 5 MeV EB. Graphite calorimeters gave reproducible readings within 3.3 % relative errors (95 % confidence level) for X-ray measurement....

  6. 3D Printing the ATLAS' barrel toroid

    CERN Document Server

    Goncalves, Tiago Barreiro

    2016-01-01

    The present report summarizes my work as part of the Summer Student Programme 2016 in the CERN IR-ECO-TSP department (International Relations – Education, Communication & Outreach – Teacher and Student Programmes). Particularly, I worked closely with the S’Cool LAB team on a science education project. This project included the 3D designing, 3D printing, and assembling of a model of the ATLAS’ barrel toroid. A detailed description of the project' development is presented and a short manual on how to use 3D printing software and hardware is attached.

  7. The crystal barrel spectrometer at LEAR

    International Nuclear Information System (INIS)

    The Crystal Barrel spectrometer used at LEAR, CERN to study the products of anti pp and anti pd annihilations is described. A 1380 element array of CsI crystals measures photons from the decay of π0, η, η' and ω mesons. A segmented drift chamber in a 1.5 T magnetic field is used to identify and measure charged particles. A fast on-line trigger on charged and neutral multiplicities and on the invariant mass of secondary particles is available. The performance of the detector is discussed. (orig.)

  8. 47 CFR 27.1214 - EBS spectrum leasing arrangements and grandfathered leases.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false EBS spectrum leasing arrangements and... Educational Broadband Service § 27.1214 EBS spectrum leasing arrangements and grandfathered leases. (a) A licensee in the EBS that is solely utilizing analog transmissions may enter into a spectrum...

  9. ATLAS TRT Barrel in Test Beam

    CERN Multimedia

    Luehring, F

    In July, the TRT group made a highly successful test of 6 Barrel TRT modules in the ATLAS H8 testbeam. Over 3000 TRT straw tubes (4 mm diameter gas drift tubes) were instrumented and found to operate well. The prototype represents 1/16 of the ATLAS TRT barrel and was assembled from TRT modules produced as spares. This was the largest scale test of the TRT to this date and the measured detector performance was as good as or better than what was expected in all cases. The 2004 TRT testbeam setup before final cabling was attached. The readout chain and central DAQ system used in the TRT testbeam is a final prototype for the ATLAS experiment. The TRT electronics used to read out the data were: The Amplifier/Shaper/Discriminator with Baseline Restoration (ASDBLR) chip is the front-end analog chip that shapes and discriminates the electronic pulses generated by the TRT straws. The Digital Time Measurement Read Out Chip (DTMROC) measures the time of the pulse relative to the beam crossing time. The TRT-ROD ...

  10. Progress of the EM Barrel Presampler Assembly

    CERN Multimedia

    Hostachy, J.Y.

    The liquid argon barrel presampler is a separate detector which will be placed in front of the electromagnetic barrel calorimeter, in the same cryostat. It is made of 32×2 sectors, each of them being 3.1 m long, about 28 cm large and a few cm thick. Three countries are involved in its construction: France (ISN-Grenoble), Sweden (KTH-Stockholm) and Morocco (Universities: Hassan II Ain Chock-Casablanca and Mohamed V-Rabat, and CNESTEN-Rabat). The design of the presampler started ten years ago and the series production began at the end of the year 2000. Today two-thirds of the sectors are produced and validated. In November 2002, half the detector (i.e. 32 sectors), was inserted on the internal face of the first EM calorimeter wheel (see pictures). Despite the fact that only 0.4 mm was available between sectors, it was possible to insert them all without meeting major difficulties. This operation was led by a team of four people, the sectors being systematically tested after insertion in the wheel. The inserti...

  11. Cosmic Ray Data in TRT Barrel

    CERN Multimedia

    M. Hance

    "I had a great day in August when I went into SR1," said Daniel Froidevaux, former project leader of the ATLAS Transition Radiation Tracker, "not only had all SCT barrels arrived at CERN, but there were cosmic ray tracks seen in the TRT!" Daniel's excitement was mirrored by the rest of the TRT collaboration when, on July 29, the first cosmic ray tracks were seen in the barrel. Along with many others in the community, Daniel was quick to point out that this is the cumulative result of years of R&D, test beam work, and an intense installation and integration schedule. Indeed, the cosmic ray readout is only possible through the coordination of many efforts, from detector mechanics to module assembly, power and high voltage control, cooling, gas systems, electronics and cabling, data acquisition, and monitoring. "Many people have worked very hard on the the TRT, some of them for more than 10 years," said Brig Williams, the leader of the UPenn group responsible for much of the TRT front end electronics. He ...

  12. Cap-Gly proteins at microtubule plus ends: is EB1 detyrosination involved?

    Directory of Open Access Journals (Sweden)

    Anouk Bosson

    Full Text Available Localization of CAP-Gly proteins such as CLIP170 at microtubule+ends results from their dual interaction with α-tubulin and EB1 through their C-terminal amino acids -EEY. Detyrosination (cleavage of the terminal tyrosine of α-tubulin by tubulin-carboxypeptidase abolishes CLIP170 binding. Can detyrosination affect EB1 and thus regulate the presence of CLIP170 at microtubule+ends as well? We developed specific antibodies to discriminate tyrosinated vs detyrosinated forms of EB1 and detected only tyrosinated EB1 in fibroblasts, astrocytes, and total brain tissue. Over-expressed EB1 was not detyrosinated in cells and chimeric EB1 with the eight C-terminal amino acids of α-tubulin was only barely detyrosinated. Our results indicate that detyrosination regulates CLIPs interaction with α-tubulin, but not with EB1. They highlight the specificity of carboxypeptidase toward tubulin.

  13. Quantitative Testing of Defect for Gun Barrels

    Institute of Scientific and Technical Information of China (English)

    WANG Chang-long; JI Feng-zhu; WANG Jin; CHEN Zheng-ge

    2007-01-01

    The magnetic flux leakage (MFL) method is commonly used in the nondestructive evaluation (NDE) of gun barrels. The key point of MFL testing is to estimate the crack geometry parameters based on the measured signal. The analysis of magnetic leakage fields can be obtained by solving Maxwell's equations using finite element method (FEM).The radial component of magnetic flux density is measured in MFL testing. The peak-peak value, the separation distance between positive and negative peaks of signal and the lift-off value of Hall-sensor are used as the main features of every sample. This paper establishes the multi-regression equations related to the width (the depth) of crack and the main characteristic values. The regression model is tested by use of the magnetic leakage data. The experimental results indicate that the regression equations can accurately predict the 2-D defect geometry parameters and the MFL quantitative testing can be achieved.

  14. 27 CFR 25.141 - Barrels and kegs.

    Science.gov (United States)

    2010-04-01

    ... OF THE TREASURY LIQUORS BEER Marks, Brands, and Labels § 25.141 Barrels and kegs. (a) General requirements. The brewer's name or trade name and the place of production (city and, if necessary for identification, State) shall be permanently marked on each barrel or keg. If the place of production is...

  15. A Finite Element Solution for Barrel Dynamic Stress

    Institute of Scientific and Technical Information of China (English)

    ZENG Zhi-yin; NING Bian-fang; WANG Zai-sen

    2007-01-01

    With the APDL language of ANSYS finite element analysis software, the solution program for barrel dynamic stress is developed. The paper describes the pivotal problems of dynamic strength design and provides a foundation for realizing the engineering and programming of barrel dynamic strength design.

  16. Experimental Research Of Charged Particles Streams, Emitted From Area Of Eb Acting On Material, In Order To Estimate The Possibilities Of Using Them To Eb Welding Control

    CERN Document Server

    Olszewska, K

    2001-01-01

    The basic parameters of electron beam (EB) welding process are position and dimensions of so called EB active zone. Wrong position of active zone make impossible to obtain desirable shape of a weld and may cause various defects of a weld. Relatively reach source of information about EB welding process are charged particles emitted from the area of EB acting on material. The measurements of various types of signals for the three largest groups of charged particles: back-scattered electrons, really secondary electrons and ions were carried out. It was estimated that practically none of them could be used directly in procedures of EB active zone position control. It is result of ambiguous of information, they contain and susceptibility to interferences or impossibility of real time data acquisition. Using the neural networks can solve this problem. The computer simulations of various models of neural networks were done. The best result was obtained for network, which has as input signals: accelerating voltage, E...

  17. Analysis of Heat Transfer in Actively Cooled Compound Gun Barrel

    Institute of Scientific and Technical Information of China (English)

    WU Bin; XIA Wei

    2005-01-01

    when a gun fires, a large amount of heat is brought in the barrel. Erosion/wear and security problems(self ignition of the propellant) associated with this high thermal energy have to be solved owing to the use of higher combustion gas temperature for improved cannon performance and firing at the sustained high rates. Barrel cooling technologies are the effective measures for addressing this issue. In view of the importance of having knowledge of the heat flux, an approach to calculate heat flux based on measurements was presented and validated. The calculated heat flux is used as the inner boundary condition for modeling heat transfer in a 155 mm mid-wall cooled compound gun barrel. Theoretical analysis and simulated results show that natural air cooling is dramatically slower than the forced liquid mid-wall cooling, accordingly wear life of actively cooled barrel is increased and barrel overheating is prevented.

  18. Using the scattered radiation energy in EB installations

    International Nuclear Information System (INIS)

    Scattered electromagnetic and backscattered electrons ionizing radiation are present outside of the beam-target geometry in direct electron beam treatments and also with the use of X-Ray converters. Most industrial EB applications do not generate neutrons or radioisotopes and the scattered radiation is treated as X-Rays for shielding calculation purposes. This scattered ionizing power has been studied as the radiation to be attenuated by the shielding and mazes. The amount of scattered radiation generated depends mainly on the material being irradiated, beam energy and current and the overall geometry. It is not constant or isotropic and its spectrum is relatively wide but, for industrial applications were irradiation conditions are maintained in narrow ranges, the average scattered radiation behavior can be estimated by previous local measurements. The behavior of the scattered radiation field can be considered chaotic, but may be evened by fluids or fluidized systems and also by fixed exposure places around the target and scan-horn. The use of these EB applications 'side effects' may replace some radioisotope and lower dose rates EB applications. For example, based on the NCRP-51, for a 1.5MeV - 60mA accelerator with low-Z target, the estimated X-ray dose rate in sideward direction is higher than from a 75kCi Cobalt-60 source. This work intends to show empirical measurements using cellulose triacetate (CTA) films in a particular geometry, exposed during some hours for each assay to establish the repeatability of the scattered radiation dose averages. An industrial application, which is normally held in almost steady state operating condition, is performed during these measurements as main irradiation. The main objective of this work is to prove that the radiation scattered, mainly from the targets, in industrial electron beam accelerators may be used for other applications where lower dose rates are needed, instead of being simply absorbed by the shielding and

  19. Technology and market of UV/EB curing in Indonesia

    International Nuclear Information System (INIS)

    Electron-beam (EB) and ultra-violet (UV) radiation are the types of irradiation systems which are being used in Indonesia for curing application. Ultra-violet curing is widely used commercially particularly in surface coating of wood and paper, printing, adhesives and electronic industries. Up to now, electron-beam curing is still in a pilot-scale step due to the economic reason. Although the equipment and chemicals tend to be more expensive than conventional systems, but radiation curing technology has been believed as an efficient and environmentally friendly technology in industrial application. This paper describes the technology and market of radiation curing in Indonesia. (author)

  20. Effects of EB irradiation on stress-strain curves for carbon fiber reinforced composite materials

    Science.gov (United States)

    Kobayashi, H.; Yamada, K.; Mizutani, A.; Uchida, N.; Tanaka, K.; Nishi, Yoshitake

    2004-02-01

    In order to evaluate influence of electron beam (EB) irradiation on elasticity and stress- strain curve of composite materials reinforced by carbon fiber (CF), carbon fiber reinforced polymer (CFRP) and carbon fiber reinforced graphite (C/C) were treated by EB irradiation of 0.3 MGy. Since the EB strengthening was mainly dominated by the ductility enhancements of carbon fiber and matrix of epoxy resin, EB irradiation enlarged fracture stress and enhanced fracture strain of CFRP. Furthermore, EB irradiation slightly enhanced bending elasticity of CFRP and largely enhanced the initial spring constant related to elasticity of C/C coil. Although the elasticity enhancement of carbon fibers did not largely contribute that of CFRP, that of treated graphite matrix in C/C mainly caused the C/C coil elasticity enhancement by EB irradiation. Such a new treatment is a dream-worthy technology for structural materials to be applied in the fields of future engineering.

  1. The CMS barrel calorimeter response to particle beams from 2-GeV/c to 350-GeV/c

    CERN Document Server

    Abdullin, S

    2009-01-01

    The response of the CMS barrel calorimeter (electromagnetic plus hadronic) to hadrons, electrons and muons over a wide momentum range from 2 to 350 GeV/c has been measured. To our knowledge, this is the widest range of momenta in which any calorimeter system has been studied. These tests, carried out at the H2 beam-line at CERN, provide a wealth of information, especially at low energies. The analysis of the differences in calorimeter response to charged pions, kaons, protons and antiprotons and a detailed discussion of the underlying phenomena are presented. We also show techniques that apply corrections to the signals from the considerably different electromagnetic (EB) and hadronic (HB) barrel calorimeters in reconstructing the energies of hadrons. Above 5 GeV/c, these corrections improve the energy resolution of the combined system where the stochastic term equals 84.7±1.6% and the constant term is 7.4±0.8%. The corrected mean response remains constant within 1.3% rms.

  2. EBS/C proton spectra from a virgin diamond crystal

    Science.gov (United States)

    Erich, M.; Kokkoris, M.; Fazinić, S.; Petrović, S.

    2016-08-01

    In the present work, elastic backscattering channeling spectra, EBS/C, of protons in a diamond crystal were experimentally and theoretically studied via a new computer simulation code. Proton incident energies for EBS/C spectra were in the energy range from 1.0 MeV to 1.9 MeV. The energy range was chosen in order to explore a distinct strong resonance of the 12C(p,p0)12C elastic scattering at 1737 keV. The computer simulation code applied for the fitting of the experimental spectra in the random mode was compared with the corresponding SIMNRA results. In the channeling mode, it assumes a Gompertz type sigmoidal dechanneling function, which has two fitting parameters, xc and k, the dechanneling range and rate, respectively. It also uses α, ratio of the channeling to random energy losses, as a fitting parameter. It was observed that xc increases, k decreases and α stays relatively constant with the proton incident energy. These observations confirm the physical interpretation of the fitting parameters. Also, they constitute the basics for the further development of the code for the quantification of induced amorphization and depth profiling of implanted ions.

  3. The EB-ANUBAD translator: A hybrid scheme

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    This article is aimed at describing a hybrid scheme for English to Bangla translation. The translated output in English scripts is useful for learning Bengali language. This is a significant contribution to Human Language Technology generation also.About two hundred million people in West Bengal and Tripura (two states in India) and in Bangladesh (a country whose people speak and write Bangla as their first language). This proposed translator would benefit Bengalee society because rural people are not usually very conversant with English. The English to Bangla Translator is being enhanced. This system (EnglishBangla-ANUBAD or EB-ANUBAD) takes a paragraph of English sentences as input sentences and produces equivalent Bangla sentences. EB-ANUBAD system is comprised of a preprocessor, morphological parser, semantic parser using English word ontology for context disambiguation, an electronic lexicon associated with grammatical information and a discourse processor,and also uses a lexical disambiguation analyzer. This system does not rely on a stochastic approach. Rather, it is based on a special kind of hybrid architecture of transformer and rule-based Natural Language Engineering (NLE) architectures along with various linguistic knowledge components of both English and Bangla.

  4. Adhesion and interface problems of EB-PVD thermal barrier coatings; Grenzschichtproblematik und Haftung von EB-PVD-Waermedaemmschichtsystemen

    Energy Technology Data Exchange (ETDEWEB)

    Fritscher, K.; Leyens, C. [Deutsche Forschungsanstalt fuer Luft- und Raumfahrt e.V. (DLR), Koeln (Germany). Inst. fuer Werkstoff-Forschung

    1996-12-31

    Loss of adhesion in thermal insulation layers produced by EB-PVD may be caused by surface morphologies or oxide phases resulting from previous process stages, e.g. shot peening, or inappropriate annealing conditions. These undesirable oxide phases are mostly spinels and silicates which pose mechanical problems. Annealing and densification must be modified in order to promote the formation of {alpha}-Al{sub 2}O{sub 3} layers. It may also be possible to avoid certain categories of flaws by changing one material partner (e.g. by using {beta}-NiAl-free adhesive layers). [Deutsch] Die Ursachen der Einbussen der Haftung in WDS-Systemen aus EB-PVD-Fertigung liegen oft in der Ausbildung von Oberflaechenmorphologien oder von Oxidphasen begruendet, die aus den der WDS-Beschichtung vorangehenden Verfahrensschritten wie z.B. des Glasperlstrahlens und von unangemessenen Gluehbedingungen herruehren koennen. Bei diesen unerwuenschten Oxidphasen handelt es sich u.a. um Spinelle und Silikate, die in mechanischer Hinsicht problematisch sind. Glueh- und Verdichtungsroutinen sind entsprechend zu modifizieren, um die Bildung von {alpha}-Al{sub 2}O{sub 3}-Schichten zu foerdern. Moeglicherweise sind gewisse Fehlerkategorien bereits dadurch zu umgehen, dass ein Materialpartner geaendert wird (Beispiel: {beta}-NiAl-freie Haftschichten anwenden). (orig.)

  5. Performance of a Rain Barrel Sharing Network under Climate Change

    OpenAIRE

    Seong Jin Noh; Eun-Sung Chung; Yongwon Seo

    2015-01-01

    Rain barrels can be technically shared through social practices or mutual agreement between individual households. This study proposes the evaluation system for a rain barrel sharing network (RBSN) considering three performance criteria of reliability, resiliency, and vulnerability, under plausible climate change scenarios. First, this study shows how the system can be improved in terms of the performance criteria using historical daily rainfall data based on the storage-reliability-yield rel...

  6. Radiation hardness, excess noise factor and short-term gain instability of vacuum phototriodes for the operation in pseudorapidity range 15 < eta < 30 at CMS ECAL

    CERN Document Server

    Blinnikov, Yu S; Gninenko, S N; Grishin, V; Goloubev, V; Katchanov, V A; Lukianov, V N; Levchenko, L A; Moroz, F V; Mamaeva, G A; Postoev, V E; Seliverstov, D M; Ukhanov, D; Yakorev, D

    2003-01-01

    The operation of super radiation hard prototypes of vacuum fine-mesh phototriodes (VPT) proposed for application in CMS Endcap ECAL at the pseudorapidity of eta greater than or equivalent 2.6 has been investigated in radiation fields up to 50 kGy and neutron fluence of 7 multiplied by 10**1**5neutroncm**-**2. It is shown that anode response and the excess noise factor of VPT are independent of given above radiation dose and neutron fluence. The results of VPT gain variation measurements under rapid changes of counting rate are presented for the operation in the pseudorapidity range 1.5 less than approximately equals eta less than approximately equals 3.0.

  7. Investigation of High-Level Synthesis tools’ applicability to data acquisition systems design based on the CMS ECAL Data Concentrator Card example

    Science.gov (United States)

    HUSEJKO, Michal; EVANS, John; RASTEIRO DA SILVA, Jose Carlos

    2015-12-01

    High-Level Synthesis (HLS) for Field-Programmable Logic Array (FPGA) programming is becoming a practical alternative to well-established VHDL and Verilog languages. This paper describes a case study in the use of HLS tools to design FPGA-based data acquisition systems (DAQ). We will present the implementation of the CERN CMS detector ECAL Data Concentrator Card (DCC) functionality in HLS and lessons learned from using HLS design flow. The DCC functionality and a definition of the initial system-level performance requirements (latency, bandwidth, and throughput) will be presented. We will describe how its packet processing control centric algorithm was implemented with VHDL and Verilog languages. We will then show how the HLS flow could speed up design-space exploration by providing loose coupling between functions interface design and functions algorithm implementation. We conclude with results of real-life hardware tests performed with the HLS flow-generated design with a DCC Tester system.

  8. Investigation of High-Level Synthesis tools’ applicability to data acquisition systems design based on the CMS ECAL Data Concentrator Card example

    CERN Document Server

    HUSEJKO, Michal; RASTEIRO DA SILVA, Jose Carlos

    2015-01-01

    High-Level Synthesis (HLS) for Field-Programmable Logic Array (FPGA) programming is becoming a practical alternative to well-established VHDL and Verilog languages. This paper describes a case study in the use of HLS tools to design FPGA-based data acquisition systems (DAQ). We will present the implementation of the CERN CMS detector ECAL Data Concentrator Card (DCC) functionality in HLS and lessons learned from using HLS design flow.The DCC functionality and a definition of the initial system-level performance requirements (latency, bandwidth, and throughput) will be presented. We will describe how its packet processing control centric algorithm was implemented with VHDL and Verilog languages. We will then show how the HLS flow could speed up design-space exploration by providing loose coupling between functions interface design and functions algorithm implementation.We conclude with results of real-life hardware tests performed with the HLS flow-generated design with a DCC Tester system.

  9. DSC analysis of EB-cured polyurethane-acrylate

    International Nuclear Information System (INIS)

    The gel films obtained by electron beam (EB) solid-state polymerization of urethane-acrylate prepolymers were characterized by differential scanning calorimetry (DSC). Two kinds of urethane-acrylates were synthesized by reaction of poly(butylene adipate)diol (PBAD), 4,4'-diphenylmethane diisocyanate (MDI) and 2-hydroxyethyl acrylate (HEA) for this purpose. One is a semicrystalline prepolymer (UA-251M) with a number average molecular weight (M-barn) of 3200, and the other is an amorphous one (UA-071M) with M-barn of 1450. The M-barn varied by changing M-barn of PBAD. UA-251M gel film decreased in glass transition temperature (Tg) and increased in heat capacity change (ΔCp) at Tg with increasing irradiation dose, while the Tg and ΔCp values of UA-071M gel film changed in the opposite way to those of UA-251M gel film. Above 5 Mrad, gel fraction reached more than 90 %, and the Tg and ΔCp values changed steeply for both prepolymers. This steep change in Tg and ΔCp was attributed to the crosslinking of PBAD chains as well as of terminal acryloyl groups. Since the Tg change of UA-071M gel film depends merely on the crosslinking, the crosslinking structure was evaluated using two equations which relate the shift in Tg to crosslinking. The molecular weight between crosslinking junctions was found to be larger than the M-barn of the prepolymer. The crosslinking by the EB polymerization restricted the mobility of the polymer chain less strongly than the crosslinking by the three-functional isocyanate and α,ω-dihydroxy(polypropylene oxide) with a molecular weight of 1000 did. (author)

  10. DSC analysis of EB-cured polyurethane-acrylate

    Energy Technology Data Exchange (ETDEWEB)

    Ando, Masayuki; Uryu, Toshiyuki

    1987-10-01

    The gel films obtained by electron beam (EB) solid-state polymerization of urethane-acrylate prepolymers were characterized by differential scanning calorimetry (DSC). Two kinds of urethane-acrylates were synthesized by reaction of poly(butylene adipate)diol (PBAD), 4,4'-diphenylmethane diisocyanate (MDI) and 2-hydroxyethyl acrylate (HEA) for this purpose. One is a semicrystalline prepolymer (UA-251M) with a number average molecular weight (M-bar/sub n/) of 3200, and the other is an amorphous one (UA-071M) with M-bar/sub n/ of 1450. The M-bar/sub n/ varied by changing M-bar/sub n/ of PBAD. UA-251M gel film decreased in glass transition temperature (T/sub g/) and increased in heat capacity change (..delta..C/sub p/) at T/sub g/ with increasing irradiation dose, while the T/sub g/ and ..delta..C/sub p/ values of UA-071M gel film changed in the opposite way to those of UA-251M gel film. Above 5 Mrad, gel fraction reached more than 90 %, and the T/sub g/ and ..delta..C/sub p/ values changed steeply for both prepolymers. This steep change in T/sub g/ and ..delta..C/sub p/ was attributed to the crosslinking of PBAD chains as well as of terminal acryloyl groups. Since the T/sub g/ change of UA-071M gel film depends merely on the crosslinking, the crosslinking structure was evaluated using two equations which relate the shift in T/sub g/ to crosslinking. The molecular weight between crosslinking junctions was found to be larger than the M-bar/sub n/ of the prepolymer. The crosslinking by the EB polymerization restricted the mobility of the polymer chain less strongly than the crosslinking by the three-functional isocyanate and ..cap alpha..,..omega..-dihydroxy(polypropylene oxide) with a molecular weight of 1000 did.

  11. 76 FR 61288 - Treatment of Aliens Whose Employment Creation Immigrant (EB-5) Petitions Were Approved After...

    Science.gov (United States)

    2011-10-04

    ... FR 59927 proposing to amend its regulations governing the employment creation (EB-5) immigrant... SECURITY 8 CFR Parts 216 and 245 RIN 1615-AA90 Treatment of Aliens Whose Employment Creation Immigrant (EB... Homeland Security corrects an inadvertent error contained in the proposed rule titled Treatment of...

  12. A barrel-related interneuron in layer 4 of rat somatosensory cortex with a high intra-barrel connectivity

    OpenAIRE

    Koelbl, C.; Helmstaedter, Moritz; Lübke, Joachim; Feldmeyer, Dirk

    2015-01-01

    Synaptic connections between identified fast-spiking (FS), parvalbumin (PV)-positive interneurons, and excitatory spiny neurons in layer 4 (L4) of the barrel cortex were investigated using patch-clamp recordings and simultaneous biocytin fillings. Three distinct clusters of FS L4 interneurons were identified based on their axonal morphology relative to the barrel column suggesting that these neurons do not constitute a homogeneous interneuron population. One L4 FS interneuron type had an axon...

  13. ELECTROMAGNET CALORIMETER (ECAL)

    CERN Multimedia

    R. Rusack

    Installation is under way of the last piece of the electromagnetic calorimeter. This is the preshower (ES) that sits in front of the two endcap calorimeters. The construction of the ES was completed in December and went through a detailed set of tests in December and January. The two preshower detectors have a total of 4300 silicon sensors with 137,000 strips. After final assembly and system testing in January, only two of the strips were found to be defective. Once CMS was fully opened a new support structure (‘Gazprom’) was put into place underneath the beam pipe, to support the Surkov platform, on which the preshower installation takes place. In the early hours of 26th February the first two Dees, which form the ‘ES+’ endcap,  were transported to P5 , a journey that took two and a half hours. The Dees, still inside environmental protection boxes, were then lowered  underground and moved to the ‘+’ end of CMS. Installation start...

  14. ELECTROMAGNETIC CALORIMETER (ECAL)

    CERN Multimedia

    D. Barney

    2012-01-01

      All necessary improvements to the online system and configuration to cope with the high-pile-up running conditions in 2012 have been commissioned successfully before the start of data-taking and during 2012 RunA. Hardware interventions included a rework of the preshower HV distribution system (increasing the number of working silicon sensor channels by 2%) and the deployment of two new lasers (blue and green) to improve the long-term stability of the monitoring system. The new lasers were deployed before the start of 2012 running and have been steadily producing monitoring constants since April, in parallel with the old laser, which is still used for the default monitoring corrections. Improvements to the DAQ include a firmware upgrade to recover on-the-fly from many types of suspected single-event upsets (SEUs). Configuration changes include new zero-suppression settings applied online and a new tuning for the algorithm to reduce the rate of anomalous signals firing the Level-1 trigger. Moreo...

  15. Reactive Transport and Coupled THM Processes in Engineering Barrier Systems (EBS)

    Energy Technology Data Exchange (ETDEWEB)

    Steefel, Carl; Rutqvist, Jonny; Tsang, Chin-Fu; Liu, Hui-Hai; Sonnenthal, Eric; Houseworth, Jim; Birkholzer, Jens

    2010-08-31

    Geological repositories for disposal of high-level nuclear wastes generally rely on a multi-barrier system to isolate radioactive wastes from the biosphere. The multi-barrier system typically consists of a natural barrier system, including repository host rock and its surrounding subsurface environment, and an engineering barrier system (EBS). EBS represents the man-made, engineered materials placed within a repository, including the waste form, waste canisters, buffer materials, backfill and seals (OECD, 2003). EBS plays a significant role in the containment and long-term retardation of radionuclide release. EBS is involved in complex thermal, hydrogeological, mechanical, chemical and biological processes, such as heat release due to radionuclide decay, multiphase flow (including gas release due to canister corrosion), swelling of buffer materials, radionuclide diffusive transport, waste dissolution and chemical reactions. All these processes are related to each other. An in-depth understanding of these coupled processes is critical for the performance assessment (PA) for EBS and the entire repository. Within the EBS group of Used Fuel Disposition (UFD) Campaign, LBNL is currently focused on (1) thermal-hydraulic-mechanical-chemical (THMC) processes in buffer materials (bentonite) and (2) diffusive transport in EBS associated with clay host rock, with a long-term goal to develop a full understanding of (and needed modeling capabilities to simulate) impacts of coupled processes on radionuclide transport in different components of EBS, as well as the interaction between near-field host rock (e.g., clay) and EBS and how they effect radionuclide release. This final report documents the progress that LBNL has made in its focus areas. Specifically, Section 2 summarizes progress on literature review for THMC processes and reactive-diffusive radionuclide transport in bentonite. The literature review provides a picture of the state-of-the-art of the relevant research areas

  16. Microtubule +TIP protein EB1 binds to GTP and undergoes dissociation from dimer to monomer on binding GTP.

    Science.gov (United States)

    Gireesh, K K; Sreeja, Jamuna S; Chakraborti, Soumyananda; Singh, Puja; Thomas, Geethu Emily; Gupta, Hindol; Manna, Tapas

    2014-09-01

    The +TIP protein EB1 autonomously tracks the growing plus end of microtubules and regulates plus-end dynamics. Previous studies have indicated that EB1 can recognize GTP-bound tubulin structures at the plus end, and it localizes on the microtubule surface at a site close to the exchangeable GTP-binding site of tubulin. Although the GTP-dependent structural change in tubulin has been demonstrated to be a critical determinant for recognition of plus ends by EB1, the effect of GTP on the structure of EB1 has remained unclear. Here, we have used spectroscopic, calorimetric, and biochemical methods to analyze the effect of GTP on EB1 in vitro. Isothermal titration calorimetry and tryptophan fluorescence quenching experiments demonstrated that EB1 binds to GTP with a dissociation constant ~30 μM. Circular dichroism measurements showed that EB1 undergoes changes in its secondary structure on binding GTP. Size-exclusion chromatography and urea-induced unfolding analyses revealed that GTP binding induces dissociation of the EB1 dimer to monomers. Size-exclusion chromatography followed by biochemical analysis further determined that EB1-GTP binding involves association of approximately one molecule of GTP per EB1 monomer. The results reveal a hitherto unknown GTP-dependent mechanism of dimer-to-monomer transition in EB1 and further implicate its possible role in regulating the stability of the EB1 dimer vs monomer as well as plus-end regulation in cells. PMID:25111064

  17. Moving HLW-EBS concepts into the 21st century

    International Nuclear Information System (INIS)

    Most national high-level waste (HLW) disposal programs actually reflect, or are based on, concepts which were developed during the '70s or early '80s. Although suitable for demonstration of concept feasibility, designs of the engineered barrier system (EBS) do not take into account the tremendous developments in system understanding and materials technology over the last two decades, the practicality (and cost) of their quality assurance and implementation on an industrial scale and the transparency of the demonstration of the safety case. In many ways, due to the increased significance of popular acceptance over the last decade, the last point may be of particular relevance This paper reviews the work already carried out on second generation concepts and extends this to identify the key attributes of an ideal design for the specific case of disposal of vitrified HLW from reprocessing in a 'wet' host rock (either crystalline or sedimentary). Based on the concept developed, key R and D requirements are identified. Copyright (2001) Material Research Society

  18. The impact of acceleration on barrel/launch package design

    International Nuclear Information System (INIS)

    This paper discusses the impact of launch acceleration on the design of electromagnetic launcher barrels and on the design of associated launch packages. This is of particular interest because launch package size and mass directly affect the overall armament system size and mass. A common design approach is to use as the peak launch acceleration, the maximum acceleration which the projectile can be designed to withstand. While this approach will minimize barrel length, it may also yield an excessively large overall system size and mass, especially for the long, slender projectile configurations which are desired for high aero-thermal and terminal ballistics performance. An alternate design approach is described which balances the goals of reducing barrel length with reducing launch package mass. Results illustrate the benefits of this balanced design approach on overall armament system size and mass

  19. Cholinergic signals in mouse barrel cortex during active whisker sensing.

    Science.gov (United States)

    Eggermann, Emmanuel; Kremer, Yves; Crochet, Sylvain; Petersen, Carl C H

    2014-12-11

    Internal brain states affect sensory perception, cognition, and learning. Many neocortical areas exhibit changes in the pattern and synchrony of neuronal activity during quiet versus active behaviors. Active behaviors are typically associated with desynchronized cortical dynamics. Increased thalamic firing contributes importantly to desynchronize mouse barrel cortex during active whisker sensing. However, a whisking-related cortical state change persists after thalamic inactivation, which is mediated at least in part by acetylcholine, as we show here by using whole-cell recordings, local pharmacology, axonal calcium imaging, and optogenetic stimulation. During whisking, we find prominent cholinergic signals in the barrel cortex, which suppress spontaneous cortical activity. The desynchronized state of barrel cortex during whisking is therefore driven by at least two distinct signals with opposing functions: increased thalamic activity driving glutamatergic excitation of the cortex and increased cholinergic input suppressing spontaneous cortical activity.

  20. Cholinergic Signals in Mouse Barrel Cortex during Active Whisker Sensing

    Directory of Open Access Journals (Sweden)

    Emmanuel Eggermann

    2014-12-01

    Full Text Available Internal brain states affect sensory perception, cognition, and learning. Many neocortical areas exhibit changes in the pattern and synchrony of neuronal activity during quiet versus active behaviors. Active behaviors are typically associated with desynchronized cortical dynamics. Increased thalamic firing contributes importantly to desynchronize mouse barrel cortex during active whisker sensing. However, a whisking-related cortical state change persists after thalamic inactivation, which is mediated at least in part by acetylcholine, as we show here by using whole-cell recordings, local pharmacology, axonal calcium imaging, and optogenetic stimulation. During whisking, we find prominent cholinergic signals in the barrel cortex, which suppress spontaneous cortical activity. The desynchronized state of barrel cortex during whisking is therefore driven by at least two distinct signals with opposing functions: increased thalamic activity driving glutamatergic excitation of the cortex and increased cholinergic input suppressing spontaneous cortical activity.

  1. Correcting the Chromatic Aberration in Barrel Distortion of Endoscopic Images

    Directory of Open Access Journals (Sweden)

    Y. M. Harry Ng

    2003-04-01

    Full Text Available Modern endoscopes offer physicians a wide-angle field of view (FOV for minimally invasive therapies. However, the high level of barrel distortion may prevent accurate perception of image. Fortunately, this kind of distortion may be corrected by digital image processing. In this paper we investigate the chromatic aberrations in the barrel distortion of endoscopic images. In the past, chromatic aberration in endoscopes is corrected by achromatic lenses or active lens control. In contrast, we take a computational approach by modifying the concept of image warping and the existing barrel distortion correction algorithm to tackle the chromatic aberration problem. In addition, an error function for the determination of the level of centroid coincidence is proposed. Simulation and experimental results confirm the effectiveness of our method.

  2. Simulation and reconstruction of the PANDA Barrel DIRC

    Energy Technology Data Exchange (ETDEWEB)

    Dzhygadlo, R., E-mail: r.dzhygadlo@gsi.de [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Gerhardt, A.; Götzen, K.; Hohler, R.; Kalicy, G.; Kumawat, H.; Lehmann, D.; Lewandowski, B.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Zühlsdorf, M. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Dodokhov, V.Kh. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Britting, A.; Eyrich, W.; Lehmann, A. [Friedrich Alexander-University of Erlangen-Nuremberg, Erlangen (Germany); and others

    2014-12-01

    Hadronic particle identification (PID) in the barrel region of the PANDA experiment at the new Facility for Antiproton and Ion Research in Europe (FAIR) at GSI, Darmstadt will be provided by a DIRC (Detection of Internally Reflected Cherenkov light) counter. To optimize the performance and reduce the detector cost, detailed simulations of different design elements, such as the width of the radiators, the shape of the expansion volume, and the type of focusing system, were performed using Geant. Custom reconstruction algorithms were developed to match the detector geometry. We will discuss the single photon resolution and photon yield as well as the PID performance for the Barrel DIRC baseline design and several detector design options. - Highlights: • Simulation of the PANDA Barrel DIRC with different design options has been performed. • A design with narrow bars and focusing system meets the PANDA PID goals. • Two reconstruction approaches were developed. • A time-based imaging reconstruction method shows promising results.

  3. Near field and altered zone environmental report Volume I: technical bases for EBS design

    Energy Technology Data Exchange (ETDEWEB)

    Wilder, D. G., LLNL

    1997-08-01

    This report presents an updated summary of results for the waste package (WP) and engineered barrier system (EBS) evaluations, including materials testing, waste-form characterization, EBS performance assessments, and near-field environment (NFE) characterization. Materials testing, design criteria and concept development, and waste-form characterization all require an understanding of the environmental conditions that will interact with the WP and EBS. The Near-Field Environment Report (NFER) was identified in the Waste Package Plan (WPP) (Harrison- Giesler, 1991) as the formal means for transmitting and documenting this information.

  4. Small arms mini-fire control system: fiber-optic barrel deflection sensor

    Energy Technology Data Exchange (ETDEWEB)

    Rajic, Slobodan [ORNL; Datskos, Panos G [ORNL

    2012-01-01

    Traditionally the methods to increase firearms accuracy, particularly at distance, have concentrated on barrel isolation (free floating) and substantial barrel wall thickening to gain rigidity. This barrel stiffening technique did not completely eliminate barrel movement but the problem was significantly reduced to allow a noticeable accuracy enhancement. This process, although highly successful, came at a very high weight penalty. Obviously the goal would be to lighten the barrel (firearm), yet achieve even greater accuracy. Thus, if lightweight barrels could ultimately be compensated for both their static and dynamic mechanical perturbations, the result would be very accurate, yet significantly lighter weight, weapons. We discuss our development of a barrel reference sensor system that is designed to accomplish this ambitious goal. Our optical fiber-based sensor monitors the barrel muzzle position and autonomously compensates for any induced perturbations. The reticle is electronically adjusted in position to compensate for the induced barrel deviation in real time.

  5. ebXML中CPP文档框架模板的研究%Study on CPP Document Framework Template Under ebXML

    Institute of Scientific and Technical Information of China (English)

    赖胜强; 郭荷清

    2002-01-01

    在近期所确定的ebXML规范中,CPP规范(Collaboration-Protocol Profile and Agreement Specification),即合作描述协议是ebXML整个体系中重要的一环.交易双方如何撰写合格的CPP文档是当前一个研究的重点,该文通过对CPP文档格式的分析,提出了一个CPP文档框架模板的概念,并且利用XMLDOM的接口,成功地实现了一个利用该模板的生成及书写器,使得交易双方都可以较为容易地撰写各自的CPP文档,为最终基于ebXML进行交易奠定了基础.

  6. Structure and characteristics of EB-PVD thermal insulation layers; Struktur und Eigenschaften von EB-PVD-Waermedaemmschichten

    Energy Technology Data Exchange (ETDEWEB)

    Schulz, U. [Deutsche Forschungsanstalt fuer Luft- und Raumfahrt e.V. (DLR), Koeln (Germany). Inst. fuer Werkstoff-Forschung

    1996-12-31

    Thermal insulation layers for guide blades and rotor blades in the first two stages of a high-pressure turbines are produced by electron-beam physical vapour deposition for maximum quality. The layers have a lifetime that is longer by a factor of 2 to 10 than for plasma-sprayed layers. The following characteristics of the ceramic layer have a decisive influence on the life of the composite system: Phase composition, distribution and stability, microstructure, density, thickness, crack distribution and cohesive strength. Some selected aspects of the interdependence between production parameters, microstructure of the thermal insulation layer and service life are gone into. [Deutsch] Zur Herstellung von Waermedaemmschichten (WDS) fuer Turbinenleit- und Laufschaufeln der ersten beiden Stufen in der Hochdruckturbine wird fuer hoechste Ansprueche an die Schichtqualitaet das EB-PDV-Verfahren (electron-beam physical vapour deposition) eingesetzt. Die Lebensdauer dieser Schichten ist um den Faktor 2 bis 10 besser als beim Plasmaspritzen. Bei der keramischen Waermedaemmschicht selbst beeinflussen folgende Eigenschaften die Lebensdauer des Gesamtschichtsystems nachhaltig: Phasenzusammensetzung, -verteilung und -stabilitaet, Mikrogefuege, Dichte, Dicke, Rissverteilung und kohaesive Festigkeit. Auf einige ausgewaehlt Aspekte des Zusammenhangs zwischen Herstellungsparametern, Mikrostruktur der Waermedaemmschicht und Lebensdauer wird kurz eingegangen. (orig.)

  7. Evaluation of the PetrifilmTM EB and TEMPO® EB systems with ISO 21528-2:2004 method for the count of Enterobacteriaceae in milk

    Directory of Open Access Journals (Sweden)

    Andréia Cirolini

    2013-09-01

    Full Text Available The development of alternative microbiological techniques is driven by the necessity to meet the current needs to deliver rapid results in the manufacturing process of foods, but it is important that these methods be evaluated for each application. The objective of the present study was to assess the PetrifilmTM EB and the TEMPO® EB systems with ISO 21528-2:2004 for the count of Enterobacteriaceae in pasteurized and UHT milk samples. We analyzed the microflora of 141 pasteurized milk samples, 15 samples of artificially contaminated pasteurized milk and 15 samples of artificially contaminated UHT milk. Investigation of the method PetrifilmTM EB and ISO 21528:2 regression analysis showed a high correlation in the samples, r = 0.90 for the microflora of pasteurized milk, r = 0.98 for artificially contaminated pasteurized milk and r = 0.99 for the artificially contaminated UHT milk. In evaluating the system TEMPO EB ® method and ISO 21528:2 correlation was also significant in the analyzed samples, with r = 0.86 for the microflora of pasteurized milk, r = 0.96 for artificially contaminated pasteurized milk and r = 0.99 for artificially contaminated UHT milk. No statistically significant differences were observed between the three methods conducted to analyze artificially contaminated pasteurized and UHT milk at three inoculum levels. In conclusion, the PetrifilmTM EB system and the TEMPO® EB system may be an alternative to the ISO 21528-2:2004 for the Enterobacteriaceae assay for milk as because of the ease-of-operation and the time reduction achieved for conducting the microbiological assay using these systems.

  8. A Methodology for Characterizing Gun Barrel Flexure due to Vehicle Motion

    Directory of Open Access Journals (Sweden)

    Mark Bundy

    2001-01-01

    Full Text Available Barrel centerline curvature is known to influence the location of projectile shot impacts. Superimposed on the unique manufactured barrel centerline is the flexed barrel shape that can occur prior to firing while the vehicle is on the move. In order to understand and quantify the effects of barrel flexure on gun accuracy, it is necessary to determine what combination of fundamental mode shapes is most likely to occur. A method to accomplish this task is described in this paper. The method is demonstrated by enumerating the 10 most likely flexed barrel shapes that were found to occur in a tank-mounted gun barrel while it traversed a bump course.

  9. Towards energy efficient climate control in storage of tulip bulbs. Pilot EB-01; Naar een energiezuiniger klimaatbeheersing bij de bewaring van tulpenbollen. Praktijkproef EB-01

    Energy Technology Data Exchange (ETDEWEB)

    Gude, H.; Dijkema, M.

    2005-09-15

    The aim of this project is to enable energy conservation in the storage of tulip bulbs. To this end, it should be examined if the agent EB-01 (1-methylcycloprene, a protection agent for plants) can be used in practical cells that are not entirely leak proof and if it offers sufficient protection against ethylene damage [Dutch] Doel van dit project is om energiebesparing bij de bewaring van tulpenbollen mogelijk te maken. Om dat te realiseren wordt onderzocht of het middel EB-01 (1- methylcyclopropeen, een beschermingsmiddel voor planten) toepasbaar is in niet volledig lekdichte praktijkcellen en voldoende bescherming tegen ethyleenschade biedt.

  10. EB welding and quality control of nuclear reactor fuel rods at ASEA-ATOM

    International Nuclear Information System (INIS)

    Fourteen years ago ASEA-ATOM chose EB welding for fuel rod plug/tube welds. This choice was made on the basis of 7 years of experience of EB-welding of fuel rods in a pilot plant. The specific reasons were the high quality and the high process yield, which are made possible by the great degree of controlability and reproducibility of this process and because the welds are suitable for QC inspection by an inline ultrasonic method which we developed at the same time. To date ASEA-ATOM has manufactured approximately 600,000 fuel rods with 1,200,000 EB-welds. The results have met expections as regards quality, process yield and service in BWR and PWR reactors. Descriptions are given of the automatic Sciaky EB welding machines, of the ultrasonic inspection equipment and of their process qualification. Some comments are made on quality and process yield

  11. Current and future market of UV/EB curing in Thailand

    International Nuclear Information System (INIS)

    Current status and future market of UV/EB curing in Thailand were presented. Included number of printing houses, export, main export market and the role of radiation curing in printing and packaging industries of Thailand

  12. Nanograined Net-Shaped Fabrication of Rhenium Components by EB-PVD

    International Nuclear Information System (INIS)

    Cost-effective net-shaped forming components have brought considerable interest into DoD, NASA and DoE. Electron beam physical vapor deposition (EB-PVD) offers flexibility in forming net-shaped components with tailored microstructure and chemistry. High purity rhenium (Re) components including rhenium-coated graphite balls, Re- plates and tubes have been successfully manufactured by EB-PVD. EB-PVD Re components exhibited sub-micron and nano-sized grains with high hardness and strength as compared to CVD. It is estimated that the cost of Re components manufactured by EB-PVD would be less than the current CVD and powder-HIP Technologies

  13. Disposal systems evaluations and tool development : Engineered Barrier System (EBS) evaluation.

    Energy Technology Data Exchange (ETDEWEB)

    Rutqvist, Jonny (LBNL); Liu, Hui-Hai (LBNL); Steefel, Carl I. (LBNL); Serrano de Caro, M. A. (LLNL); Caporuscio, Florie Andre (LANL); Birkholzer, Jens T. (LBNL); Blink, James A. (LLNL); Sutton, Mark A. (LLNL); Xu, Hongwu (LANL); Buscheck, Thomas A. (LLNL); Levy, Schon S. (LANL); Tsang, Chin-Fu (LBNL); Sonnenthal, Eric (LBNL); Halsey, William G. (LLNL); Jove-Colon, Carlos F.; Wolery, Thomas J. (LLNL)

    2011-01-01

    Key components of the nuclear fuel cycle are short-term storage and long-term disposal of nuclear waste. The latter encompasses the immobilization of used nuclear fuel (UNF) and radioactive waste streams generated by various phases of the nuclear fuel cycle, and the safe and permanent disposition of these waste forms in geological repository environments. The engineered barrier system (EBS) plays a very important role in the long-term isolation of nuclear waste in geological repository environments. EBS concepts and their interactions with the natural barrier are inherently important to the long-term performance assessment of the safety case where nuclear waste disposition needs to be evaluated for time periods of up to one million years. Making the safety case needed in the decision-making process for the recommendation and the eventual embracement of a disposal system concept requires a multi-faceted integration of knowledge and evidence-gathering to demonstrate the required confidence level in a deep geological disposal site and to evaluate long-term repository performance. The focus of this report is the following: (1) Evaluation of EBS in long-term disposal systems in deep geologic environments with emphasis on the multi-barrier concept; (2) Evaluation of key parameters in the characterization of EBS performance; (3) Identification of key knowledge gaps and uncertainties; and (4) Evaluation of tools and modeling approaches for EBS processes and performance. The above topics will be evaluated through the analysis of the following: (1) Overview of EBS concepts for various NW disposal systems; (2) Natural and man-made analogs, room chemistry, hydrochemistry of deep subsurface environments, and EBS material stability in near-field environments; (3) Reactive Transport and Coupled Thermal-Hydrological-Mechanical-Chemical (THMC) processes in EBS; and (4) Thermal analysis toolkit, metallic barrier degradation mode survey, and development of a Disposal Systems

  14. CMS detects the first muons crossing two barrel sectors

    CERN Multimedia

    Franco Gonella

    2006-01-01

    These are some snapshots from the first cosmic muons crossing sectors 11 and 10 of the CMS barrel wheel YB+2. Five chambers were powered up using the final HV system. With a trigger rate of about 1 Hz, over 26000 events were collected in about 6 hours.

  15. End of the EM Barrel Presampler Construction and Insertion

    CERN Multimedia

    Hostachy, J.Y.

    The liquid argon barrel presampler is a thin detector placed in front of the electromagnetic barrel calorimeter, made up of two half barrels also, but with 32 sectors per half barrel instead of 16. Each of these 64 sectors is 3.1 m long, 28 cm large and 2.9 cm thick. Three countries took part in its construction: France (LPSC-Grenoble), Sweden (KTH-Stockholm) and Morocco (Hassan II Ain Chock-Casablanca and Mohamed V-Rabat universities, and CNESTEN-Rabat). The design of the presampler started 11 years ago and the series production began at the end of 2000. Cabling, mechanical and electronic tests of the anodes were achieved in Morocco. Forty-one sectors were assembled and validated at the LPSC-Grenoble and 25 at the KTH-Stockholm. In November 2002, the first half was inserted on the inner face of the first EM calorimeter wheel. The insertion of the other 32 sectors in the second EM calorimeter wheel was achieved in July 2003 (see pictures). The production of two additional sectors will allow us to study the p...

  16. ATLAS-Lowering the first Barrel Toroid coil

    CERN Multimedia

    2004-01-01

    Cranes lowered the first of ATLAS's eight Barrel Toroid coils into the cavern. The part is 25 metres long and the cranes had to hold the 100 tonne coil at a sharp angle while it passed through the 18-metre diameter vertical shaft into the cavern. Then they laid the magnet to a horisontal robust platform. Images from Camera 1

  17. ATLAS-Lowering the first Barrel Toroid coil

    CERN Multimedia

    CERN Audiovisual Unit

    2004-01-01

    Cranes lowered the first of ATLAS's eight Barrel Toroid coils into the cavern. The part is 25 meters long and the cranes had to hold the 100 tonne coil at a sharp angle while it passed through the 18-meter diameter vertical shaft into the cavern. Then they laid the magnet to a horizontal robust platform. Images from Camera 2

  18. Barrelettes without barrels in the American water shrew.

    Directory of Open Access Journals (Sweden)

    Kenneth C Catania

    Full Text Available Water shrews (Sorex palustris depend heavily on their elaborate whiskers to navigate their environment and locate prey. They have small eyes and ears with correspondingly small optic and auditory nerves. Previous investigations have shown that water shrew neocortex is dominated by large representations of the whiskers in primary and secondary somatosensory cortex (S1 and S2. Flattened sections of juvenile cortex processed for cytochrome oxidase revealed clear borders of the whisker pad representation in S1, but no cortical barrels. We were therefore surprised to discover prominent barrelettes in brainstem of juvenile water shrews in the present investigation. These distinctive modules were found in the principal trigeminal nucleus (PrV, and in two of the three spinal trigeminal subnuclei (interpolaris--SpVi and caudalis--SpVc. Analysis of the shrew's whisker pad revealed the likely relationship between whiskers and barrelettes. Barrelettes persisted in adult water shrew PrV, but barrels were also absent from adult cortex. Thus in contrast to mice and rats, which have obvious barrels in primary somatosensory cortex and less clear barrelettes in the principal nucleus, water shrews have clear barrelettes in the brainstem and no barrels in the neocortex. These results highlight the diverse ways that similar mechanoreceptors can be represented in the central nervous systems of different species.

  19. Measurement Technology on 200 Liters Barrels of Radioactive Waste

    Institute of Scientific and Technical Information of China (English)

    BAI; Lei; SHAO; Jie-wen; LIU; Da-ming; LIU; Hong-bin; CHENG; Yi-mei; HE; Li-xia; ZHU; Li-qun

    2012-01-01

    <正>The measurement device on 200 liters barrel of radioactive waste is designed following the rule of orderly measurement automatically, by using the technology of non-destructive to measure the mass of radioactive waste produced from fuel cycle. Device objects as shown in Fig. 1, which consists of the

  20. Increasing the load bearing capacity of barrel vaults

    NARCIS (Netherlands)

    Kamerling, M.W.

    2011-01-01

    Just after World War II many barrel vaults and domes were built with a structural system, known as Fusée Ceramique. This paper analyses the load bearing capacity of these vaults. Schemes, theories, idealizations and assumptions are analysed, validated and discussed. Methods to increase the load bear

  1. New results in meson spectroscopy from the crystal barrel experiment

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, C.A. [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    1994-04-01

    Recent observations by the Crystal Barrel experiment of two scalar resonances, f{sub o}(1365) and a{sub o}(1450) have allowed the authors to clarify the members of the scalar nonet. In addition, a third scalar, f{sub o}(1500), appears to be supernumerary, and is a candidate for the scalar glueball expected near 1500 MeV.

  2. The Leber congenital amaurosis protein AIPL1 and EB proteins co-localize at the photoreceptor cilium.

    Directory of Open Access Journals (Sweden)

    Juan Hidalgo-de-Quintana

    Full Text Available The aim of this study was to investigate the interaction and co-localization of novel interacting proteins with the Leber congenital amaurosis (LCA associated protein aryl hydrocarbon receptor interacting protein-like 1 (AIPL1.The CytoTrapXR yeast two-hybrid system was used to screen a bovine retinal cDNA library. A novel interaction between AIPL1 and members of the family of EB proteins was confirmed by directed yeast two-hybrid analysis and co-immunoprecipitation assays. The localization of AIPL1 and the EB proteins in cultured cells and in retinal cryosections was examined by immunofluorescence microscopy and cryo-immunogold electron microscopy.Yeast two-hybrid (Y2H analysis identified the interaction between AIPL1 and the EB proteins, EB1 and EB3. EB1 and EB3 were specifically co-immunoprecipitated with AIPL1 from SK-N-SH neuroblastoma cells. In directed 1:1 Y2H analysis, the interaction of EB1 with AIPL1 harbouring the LCA-causing mutations A197P, C239R and W278X was severely compromised. Immunofluorescent confocal microscopy revealed that AIPL1 did not co-localize with endogenous EB1 at the tips of microtubules, endogenous EB1 at the microtubule organising centre following disruption of the microtubule network, or with endogenous β-tubulin. Moreover, AIPL1 did not localize to primary cilia in ARPE-19 cells, whereas EB1 co-localized with the centrosomal marker pericentrin at the base of primary cilia. However, both AIPL1 and the EB proteins, EB1 and EB3, co-localized with centrin-3 in the connecting cilium of photoreceptor cells. Cryo-immunogold electron microscopy confirmed the co-localization of AIPL1 and EB1 in the connecting cilia in human retinal photoreceptors.AIPL1 and the EB proteins, EB1 and EB3, localize at the connecting cilia of retinal photoreceptor cells, but do not co-localize in the cellular microtubule network or in primary cilia in non-retinal cells. These findings suggest that AIPL1 function in these cells is not related

  3. Engineered Barrier Systems (EBS) in the safety case: the role of modelling workshop proceedings

    International Nuclear Information System (INIS)

    In the deep disposal of radioactive waste, the presence of several barriers serving complementary safety functions enhances confidence that the waste will be isolated and contained to protect human health and the environment. The barriers include the natural geological barrier and the engineered barrier system (EBS). The EBS itself may comprise a variety of sub-systems or components, such as the waste form, container, buffer, backfill, seals and plugs. The Integration Group for the Safety Case (IGSC) of the Nuclear Energy Agency (NEA) is co-sponsoring a series of workshops with the European Commission to develop greater understanding of how to achieve the necessary integration for the successful design, testing, modelling and performance assessment of engineered barrier systems (EBS) for deep underground disposal of radioactive waste. These proceedings include the main findings and presented papers from the third NEA-EC workshop on engineered barrier systems, which focused on the role of EBS modelling in the safety case for deep disposal. Some national programmes are placing increased emphasis on EBS and, as implementation of underground repositories approaches, more realistic assessments of EBS performance are needed. The workshop examined the modelling tools currently available and identified complex areas of assessment in which further dialogue is needed. (author)

  4. Engineered Barrier Systems (EBS) in the safety case: design confirmation and demonstration

    International Nuclear Information System (INIS)

    The presence of several barriers serving complementary safety functions enhances confidence that radioactive waste placed in deep geological repositories will be adequately isolated and contained to protect human health and the environment. The barriers include the natural geological barrier and the engineered barrier system (EBS). The EBS itself may comprise a variety of sub-systems or components, such as the waste form, container, buffer, backfill, seals and plugs. Given the importance of this subject, the Integration Group for the Safety Case (IGSC) of the OECD Nuclear Energy Agency (NEA) sponsored a series of workshops with the European Commission to develop greater understanding of how to achieve the necessary integration for the successful design, testing, modelling and performance assessment of EBS for deep underground disposal of radioactive waste. These proceedings present the main findings from, and the papers delivered at, the fourth NEA-EC workshop on EBS, which took place in Tokyo, Japan, in September 2006. This final workshop of the series focused on strategies and methods to demonstrate that EBS designs will fulfill the relevant requirements for long-term safety, engineering feasibility and quality assurance. The workshop highlighted that large-scale experiments have confirmed the feasibility of techniques for manufacturing and installing engineered components in disposal systems and have also provided valuable lessons to improve designs and refine practical aspects to construct and implement EBS. (author)

  5. Design of Radioactive Reference Barrels and Simulation Verification of Linear Source

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Shell source method was used to prepare radioactive reference barrel for the calibration of gamma scan device because filling method in normal ways produces "hot" points easily and decrease the safety in transportation of the barrel.

  6. Single photon detection and localization accuracy with an ebCMOS camera

    Energy Technology Data Exchange (ETDEWEB)

    Cajgfinger, T. [CNRS/IN2P3, Institut de Physique Nucléaire de Lyon, Villeurbanne F-69622 (France); Dominjon, A., E-mail: agnes.dominjon@nao.ac.jp [Université de Lyon, Université de Lyon 1, Lyon 69003 France. (France); Barbier, R. [CNRS/IN2P3, Institut de Physique Nucléaire de Lyon, Villeurbanne F-69622 (France); Université de Lyon, Université de Lyon 1, Lyon 69003 France. (France)

    2015-07-01

    The CMOS sensor technologies evolve very fast and offer today very promising solutions to existing issues facing by imaging camera systems. CMOS sensors are very attractive for fast and sensitive imaging thanks to their low pixel noise (1e-) and their possibility of backside illumination. The ebCMOS group of IPNL has produced a camera system dedicated to Low Light Level detection and based on a 640 kPixels ebCMOS with its acquisition system. After reminding the principle of detection of an ebCMOS and the characteristics of our prototype, we confront our camera to other imaging systems. We compare the identification efficiency and the localization accuracy of a point source by four different photo-detection devices: the scientific CMOS (sCMOS), the Charge Coupled Device (CDD), the Electron Multiplying CCD (emCCD) and the Electron Bombarded CMOS (ebCMOS). Our ebCMOS camera is able to identify a single photon source in less than 10 ms with a localization accuracy better than 1 µm. We report as well efficiency measurement and the false positive identification of the ebCMOS camera by identifying more than hundreds of single photon sources in parallel. About 700 spots are identified with a detection efficiency higher than 90% and a false positive percentage lower than 5. With these measurements, we show that our target tracking algorithm can be implemented in real time at 500 frames per second under a photon flux of the order of 8000 photons per frame. These results demonstrate that the ebCMOS camera concept with its single photon detection and target tracking algorithm is one of the best devices for low light and fast applications such as bioluminescence imaging, quantum dots tracking or adaptive optics.

  7. Single photon detection and localization accuracy with an ebCMOS camera

    Science.gov (United States)

    Cajgfinger, T.; Dominjon, A.; Barbier, R.

    2015-07-01

    The CMOS sensor technologies evolve very fast and offer today very promising solutions to existing issues facing by imaging camera systems. CMOS sensors are very attractive for fast and sensitive imaging thanks to their low pixel noise (1e-) and their possibility of backside illumination. The ebCMOS group of IPNL has produced a camera system dedicated to Low Light Level detection and based on a 640 kPixels ebCMOS with its acquisition system. After reminding the principle of detection of an ebCMOS and the characteristics of our prototype, we confront our camera to other imaging systems. We compare the identification efficiency and the localization accuracy of a point source by four different photo-detection devices: the scientific CMOS (sCMOS), the Charge Coupled Device (CDD), the Electron Multiplying CCD (emCCD) and the Electron Bombarded CMOS (ebCMOS). Our ebCMOS camera is able to identify a single photon source in less than 10 ms with a localization accuracy better than 1 μm. We report as well efficiency measurement and the false positive identification of the ebCMOS camera by identifying more than hundreds of single photon sources in parallel. About 700 spots are identified with a detection efficiency higher than 90% and a false positive percentage lower than 5. With these measurements, we show that our target tracking algorithm can be implemented in real time at 500 frames per second under a photon flux of the order of 8000 photons per frame. These results demonstrate that the ebCMOS camera concept with its single photon detection and target tracking algorithm is one of the best devices for low light and fast applications such as bioluminescence imaging, quantum dots tracking or adaptive optics.

  8. Simulation and reconstruction of the PANDA Barrel DIRC

    Science.gov (United States)

    Dzhygadlo, R.; Gerhardt, A.; Go¨tzen, K.; Hohler, R.; Kalicy, G.; Kumawat, H.; Lehmann, D.; Lewandowski, B.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Zühlsdorf, M.; Dodokhov, V. Kh.; Britting, A.; Eyrich, W.; Lehmann, A.; Uhlig, F.; Düren, M.; Fo¨hl, K.; Hayrapetyan, A.; Kro¨ck, B.; Merle, O.; Rieke, J.; Cowie, E.; Keri, T.; Montgomery, R.; Rosner, G.; Achenbach, P.; Cardinali, M.; Hoek, M.; Lauth, W.; Sfienti, C.; Thiel, M.; Bühler, P.; Gruber, L.; Marton, J.; Suzuki, K.

    2014-12-01

    Hadronic particle identification (PID) in the barrel region of the PANDA experiment at the new Facility for Antiproton and Ion Research in Europe (FAIR) at GSI, Darmstadt will be provided by a DIRC (Detection of Internally Reflected Cherenkov light) counter. To optimize the performance and reduce the detector cost, detailed simulations of different design elements, such as the width of the radiators, the shape of the expansion volume, and the type of focusing system, were performed using Geant. Custom reconstruction algorithms were developed to match the detector geometry. We will discuss the single photon resolution and photon yield as well as the PID performance for the Barrel DIRC baseline design and several detector design options.

  9. ATLAS barrel toroid integration and test area in building 180

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    The ATLAS barrel toroid system consists of eight coils, each of axial length 25.3 m, assembled radially and symmetrically around the beam axis. The coils are of a flat racetrack type with two 'double-pancake' windings made of 20.5 kA aluminium-stabilized niobium-titanium superconductor. The barrel toroid is being assembled in building 180 on the Meyrin site. In the first phase of assembly, the coils are packed into their aluminium-alloy casing. These photos show the double-pancake coils from ANSALDO and the coil casings from ALSTOM. In the foreground is the tooling from COSMI used to turn over the coil casings during this first phase. In the right background is the yellow lifting gantry manufactured at JINR-Dubna, Russia which will transport the coil casings to a heating table for prestressing. Two test benches with magnetic mirror are also visible.

  10. Experiences developing socially acceptable interactions for a robotic trash barrel

    DEFF Research Database (Denmark)

    Yang, Stephen; Mok, Brian Ka Jun; Sirkin, David;

    2015-01-01

    Service robots in public places need to both understand environmental cues and move in ways that people can understand and predict. We developed and tested interactions with a trash barrel robot to better understand the implicit protocols for public interaction. In eight lunch-time sessions spread...... across two crowded campus dining destinations, we experimented with piloting our robot in Wizard of Oz fashion, initiating and responding to requests for impromptu interactions centered on collecting people's trash. Our studies progressed from open-ended experimentation to testing specific interaction...... strategies that seemed to evoke clear engagement and responses, both positive and negative. Observations and interviews show that a) people most welcome the robot's presence when they need its services and it actively advertises its intent through movement; b) people create mental models of the trash barrel...

  11. Isolation and characterization of Bacillus subtilis EB-28, an endophytic bacterium strain displaying biocontrol activity against Botrytis cinerea Pers

    Institute of Scientific and Technical Information of China (English)

    Shutong WANG; Tongle HU; Yanling JIAO; Jianjian WEI; Keqiang CAO

    2009-01-01

    The fungal pathogen Botrytis cinerea Pers. causes severe rotting on tomato fruits during storage and shelf life. As a biological control agent, endophytic bacterium was regarded as an effective alternative to chemical control. Out of 238 endophytic bacterial isolates, three strains (EB-15, EB-28, and EB-122) isolated from Lycopersicum esculentum Mill., Speranskia tuberculata (Bge.) Baill, and Dictamnus dasycarpus Turcz. respectively were found to be strongly antagonistic to the pathogen in vitro and were selected for further in vivo tests. One endophytic bacterium strain, encoded EB-28, was selected from the three in vivo tested isolates. The inhibitive rate of EB-28 reached 71.1% in vitro and 52.4% in vivo. EB-28 was identified as Bacillus subtilis according to its morphological, physiological, and biochemical characteristics and 16S rDNA sequence analysis.

  12. International Collaborations on Engineered Barrier Systems: Brief Overview of SKB-EBS Activities.

    Energy Technology Data Exchange (ETDEWEB)

    Jove-Colon, Carlos F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-10-01

    Research collaborations with international partners on the behavior and performance of engineered barrier systems (EBS) are an important aspect of the DOE-NE Used Fuel Disposition Campaign strategy in the evaluation of disposal design concepts. These international partnerships are a cost-effective way of engaging in key R&D activities with common goals resulting in effective scientific knowledge exchanges thus enhancing existing and future research programs in the USA. This report provides a brief description of the activities covered by the Swedish Nuclear Fuel and Waste Management Company (SKB) EBS Task Force (TF) (referred hereafter as SKB EBS TF) and potential future directions for engagement of the DOE-NE UFDC program in relevant R&D activities. Emphasis is given to SKB EBS TF activities that are still ongoing and aligned to the UFDC R&D program. This include utilization of data collected in the bentonite rock interaction experiment (BRIE) and data sets from benchmark experiments produced by the chemistry or “C” part of the SKB EBS TF. Potential applications of information generated by this program include comparisons/tests between model and data (e.g., reactive diffusion), development and implementation of coupled-process models (e.g., HM), and code/model benchmarking.

  13. Technical Diagnostics of Tank Cannon Smooth Barrel Bore and Ramming Device

    Directory of Open Access Journals (Sweden)

    Jiri Balla

    2015-09-01

    Full Text Available The technical diagnostics of 125 mm tank cannon 2A46 smooth barrel and ramming devices are discussed respectively. Focuses on barrel diagnostics and suggests new procedures based on reconstructed BG20 Gun Barrel Bore Gauge System, measuring internal diameter of the barrel bore. The new system measures throughout the whole barrel bore the inner diameter not only at the beginning of barrel bore as it was usually measured before. Different nature of barrel wear was revealed between barrels firing sub-calibre and high explosive projectiles. A method for ramming device diagnostics is presented. An accurate method was proposed, determining projectile extraction force from barrel, as one of the main ramming device parameters for weapons that are used in all areas of armed forces. Results are based on experimental methods assessing the extraction forces from barrel after projectile loading. These tests were performed as a series of tests with consequent technical diagnostics according to the new Czech Defence Standards (derived from NATO standards. The results are presented as the new methodologies for diagnostics of 125 mm barrel 2A46 and ramming devices of tank T-72 for use by technical logistic units in the Czech Republic Armed Forces.

  14. Energy metrics for driving competitiveness of countries: Energy weakness magnitude, GDP per barrel and barrels per capita

    Energy Technology Data Exchange (ETDEWEB)

    Coccia, Mario, E-mail: m.coccia@ceris.cnr.i [National Research Council of Italy, CERIS-CNR, Institute for Economic Research on Firm and Growth, Collegio Carlo Alberto-via Real Collegio, n. 30, 10024 Moncalieri (Torino) (Italy)

    2010-03-15

    Energy metrics is the development of a whole new theoretical framework for the conception and measurement of energy and economic system performances, energy efficiency and productivity improvements with important political economy implications consistent with the best use of all natural and economic resources. The purpose of this research is to present some vital energy indicators based on magnitude and scale of energy weakness, GDP per barrel of oil that is an indicator of energy productivity and barrels (of oil) per capita that is an indicator of energy efficiency. Energy metrics can support the monitoring of energy and economic system performances in order to design effective energy strategy and political economy interventions focused on the 'competitive advantage' increase of countries in modern economies.

  15. Energy metrics for driving competitiveness of countries. Energy weakness magnitude, GDP per barrel and barrels per capita

    Energy Technology Data Exchange (ETDEWEB)

    Coccia, Mario [National Research Council of Italy, CERIS-CNR, Institute for Economic Research on Firm and Growth, Collegio Carlo Alberto - via Real Collegio, n. 30, 10024 Moncalieri (Torino) (Italy)

    2010-03-15

    Energy metrics is the development of a whole new theoretical framework for the conception and measurement of energy and economic system performances, energy efficiency and productivity improvements with important political economy implications consistent with the best use of all natural and economic resources. The purpose of this research is to present some vital energy indicators based on magnitude and scale of energy weakness, GDP per barrel of oil that is an indicator of energy productivity and barrels (of oil) per capita that is an indicator of energy efficiency. Energy metrics can support the monitoring of energy and economic system performances in order to design effective energy strategy and political economy interventions focused on the 'competitive advantage' increase of countries in modern economies. (author)

  16. Energy metrics for driving competitiveness of countries: Energy weakness magnitude, GDP per barrel and barrels per capita

    International Nuclear Information System (INIS)

    Energy metrics is the development of a whole new theoretical framework for the conception and measurement of energy and economic system performances, energy efficiency and productivity improvements with important political economy implications consistent with the best use of all natural and economic resources. The purpose of this research is to present some vital energy indicators based on magnitude and scale of energy weakness, GDP per barrel of oil that is an indicator of energy productivity and barrels (of oil) per capita that is an indicator of energy efficiency. Energy metrics can support the monitoring of energy and economic system performances in order to design effective energy strategy and political economy interventions focused on the 'competitive advantage' increase of countries in modern economies.

  17. Three New Pierce's Disease Pathogenicity Effectors Identified Using Xylella fastidiosa Biocontrol Strain EB92-1.

    Directory of Open Access Journals (Sweden)

    Shujian Zhang

    Full Text Available Xylella fastidiosa (X. fastidiosa infects a wide range of plant hosts and causes economically serious diseases, including Pierce's Disease (PD of grapevines. X. fastidiosa biocontrol strain EB92-1 was isolated from elderberry and is infectious and persistent in grapevines but causes only very slight symptoms under ideal conditions. The draft genome of EB92-1 revealed that it appeared to be missing genes encoding 10 potential PD pathogenicity effectors found in Temecula1. Subsequent PCR and sequencing analyses confirmed that EB92-1 was missing the following predicted effectors found in Temecula1: two type II secreted enzymes, including a lipase (LipA; PD1703 and a serine protease (PD0956; two identical genes encoding proteins similar to Zonula occludens toxins (Zot; PD0915 and PD0928, and at least one relatively short, hemagglutinin-like protein (PD0986. Leaves of tobacco and citrus inoculated with cell-free, crude protein extracts of E. coli BL21(DE3 overexpressing PD1703 exhibited a hypersensitive response (HR in less than 24 hours. When cloned into shuttle vector pBBR1MCS-5, PD1703 conferred strong secreted lipase activity to Xanthomonas citri, E. coli and X. fastidiosa EB92-1 in plate assays. EB92-1/PD1703 transformants also showed significantly increased disease symptoms on grapevines, characteristic of PD. Genes predicted to encode PD0928 (Zot and a PD0986 (hemagglutinin were also cloned into pBBR1MCS-5 and moved into EB92-1; both transformants also showed significantly increased symptoms on V. vinifera vines, characteristic of PD. Together, these results reveal that PD effectors include at least a lipase, two Zot-like toxins and a possibly redundant hemagglutinin, none of which are necessary for parasitic survival of X. fastidiosa populations in grapevines or elderberry.

  18. Three New Pierce's Disease Pathogenicity Effectors Identified Using Xylella fastidiosa Biocontrol Strain EB92-1.

    Science.gov (United States)

    Zhang, Shujian; Chakrabarty, Pranjib K; Fleites, Laura A; Rayside, Patricia A; Hopkins, Donald L; Gabriel, Dean W

    2015-01-01

    Xylella fastidiosa (X. fastidiosa) infects a wide range of plant hosts and causes economically serious diseases, including Pierce's Disease (PD) of grapevines. X. fastidiosa biocontrol strain EB92-1 was isolated from elderberry and is infectious and persistent in grapevines but causes only very slight symptoms under ideal conditions. The draft genome of EB92-1 revealed that it appeared to be missing genes encoding 10 potential PD pathogenicity effectors found in Temecula1. Subsequent PCR and sequencing analyses confirmed that EB92-1 was missing the following predicted effectors found in Temecula1: two type II secreted enzymes, including a lipase (LipA; PD1703) and a serine protease (PD0956); two identical genes encoding proteins similar to Zonula occludens toxins (Zot; PD0915 and PD0928), and at least one relatively short, hemagglutinin-like protein (PD0986). Leaves of tobacco and citrus inoculated with cell-free, crude protein extracts of E. coli BL21(DE3) overexpressing PD1703 exhibited a hypersensitive response (HR) in less than 24 hours. When cloned into shuttle vector pBBR1MCS-5, PD1703 conferred strong secreted lipase activity to Xanthomonas citri, E. coli and X. fastidiosa EB92-1 in plate assays. EB92-1/PD1703 transformants also showed significantly increased disease symptoms on grapevines, characteristic of PD. Genes predicted to encode PD0928 (Zot) and a PD0986 (hemagglutinin) were also cloned into pBBR1MCS-5 and moved into EB92-1; both transformants also showed significantly increased symptoms on V. vinifera vines, characteristic of PD. Together, these results reveal that PD effectors include at least a lipase, two Zot-like toxins and a possibly redundant hemagglutinin, none of which are necessary for parasitic survival of X. fastidiosa populations in grapevines or elderberry. PMID:26218423

  19. Validade convergente do tipo de vivência (EB no teste de Zulliger/SC = Convergent validity evidence of the personality Style (EB in Z-test/SC

    Directory of Open Access Journals (Sweden)

    Villemor-Amaral, Anna Elisa de

    2012-01-01

    Full Text Available O Zulliger foi adaptado para o Sistema Compreensivo de Exner numa amostra brasileira, pois embora o Sistema Compreensivo tenha sido desenvolvido para codificação e interpretação do método de Rorschach, a semelhança entre as duas técnicas levou a supor que o Zulliger poderia se beneficiar das mesmas vantagens alcançadas para o Rorschach. Esse estudo tem por objetivo verificar evidências de validade convergente para a classificação do Tipo de Vivência (EB no Zulliger, por meio de correlações com o indicador EB do Rorschach. Selecionaram-se de um banco de dados 51 protocolos de adultos, de ambos os sexos, com idade, escolaridade e nível socioeconômicos variados. As pessoas responderam a técnica de Zulliger e do Rorschach em dias consecutivos, alternando-se a ordem de aplicação das técnicas. Os resultados indicaram correlações significativas, mas apontam à necessidade de estabelecer novas proporções das variáveis que compõe o EB para a técnica de Zulliger

  20. Ultrasonic examination of stainless steel EB welds by an immersion technique

    International Nuclear Information System (INIS)

    The authors report the development of an ultrasonic examination method of austenitic stainless steel electron beam (EB) welds. This method is based on an automatic immersion technique employing focused transducers and is aimed at detecting both the weld soundness and penetration. The authors describe the examination procedure with a calibration of the ultrasonic equipment, a complete weld scanning, and a repetition of the calibration for matters of verification. They also describe how results are interpreted in terms of wave soundness (attenuation) and weld penetration. They discuss the reliability of the examination procedure. They comment results obtained for EB butt welds in a AISI 304 pipe

  1. The barrel muon spectrometer of the ATLAS detector has acquired its first cosmic event in a magnetic field produced by the barrel toroid magnet.

    CERN Multimedia

    2006-01-01

    A 3-D event display of a cosmic muon event, showing the path of a muon travelling through three layers of the barrel muon spectrometer. Three of the eight coils of the barrel toroid magnet can be seen in the top half of the drawing.

  2. The EB Factory Project. II. Validation with the Kepler Field in Preparation for K2 and TESS

    CERN Document Server

    Parvizi, Mahmoud; Stassun, Keivan G

    2014-01-01

    Large repositories of high precision light curve data, such as the Kepler data set, provide the opportunity to identify astrophysically important eclipsing binary (EB) systems in large quantities. However, the rate of classical "by eye" human analysis restricts complete and efficient mining of EBs from these data using classical techniques. To prepare for mining EBs from the upcoming K2 mission as well as other current missions, we developed an automated end-to-end computational pipeline - the Eclipsing Binary Factory (EBF) - that automatically identifies EBs and classifies them into morphological types. The EBF has been previously tested on ground-based light curves. To assess the performance of the EBF in the context of space-based data, we apply the EBF to the full set of light curves in the Kepler "Q3" Data Release. We compare the EBs identified from this automated approach against the human generated Kepler EB Catalog of ~2,600 EBs. When we require EB classification with at least 90% confidence, we find ...

  3. 76 FR 59927 - Treatment of Aliens Whose Employment Creation Immigrant (EB-5) Petitions Were Approved After...

    Science.gov (United States)

    2011-09-28

    ... SECURITY 8 CFR Parts 216 and 245 RIN 1615-AA90 Treatment of Aliens Whose Employment Creation Immigrant (EB... applications and petitions of qualifying aliens whose employment-creation immigrant petitions were approved by...-273 Provisions C. Summary of the Adjudications Required by Public Law 107-273 III. Aliens Eligible...

  4. Narvas näeb Eesti tantsuauhinna võitnud tantsulavastust / Rene Nõmmik ; intervjueerinud Tiia Linnart

    Index Scriptorium Estoniae

    Nõmmik, Rene, 1962-

    2015-01-01

    Narva kultuurimajas Rugodiv näeb Fine5 tantsuteatri lavastust "...and blue", mis võitis tänavu Eesti teatriauhinna. Etenduse koreograafideks ja lavastajateks on Tiina Ollesk ja Rene Nõmmik, keda on palutud lavastama ka Venemaale. Intervjuu Rene Nõmmikuga

  5. Enhanced -->E*-->B drift effects in the TCV snowflake divertor

    NARCIS (Netherlands)

    G.P. Canal,; Lunt, T.; Reimerdes, H.; Duval, B. P.; Labit, B.; Vijvers, W. A. J.; TCV team,

    2015-01-01

    Measurements of various plasma parameters at the divertor targets of snowflake (SF) and conventional single-null configurations indicate an enhanced effect of the -->E*-->B drift in the scrape-off layer of plasmas in the SF configuration. Plasma boundary transport simulations using the EMC3-Ei

  6. First physics pulses in the Barrel Electromagnetic Calorimeter with cosmics

    CERN Multimedia

    Laurent Serin

    2006-01-01

    The electromagnetic barrel calorimeter has been installed in its final position in October 2005. Since then, the calorimeter is being equipped with front-end electronics. Starting in April 2006, electronics calibration runs are taken a few times per week to debug the electronics and to study the performance in the pit (stability, noise). Today, 10 out of the 32 Front End crates are being read out, amounting to about 35000 channels. cool down, few little typos --> After a 6-week cool down, the barrel cryostat was filled with Liquid Argon in May. The presence of a few shorts (~1MΩ) at the edges of the modules was indicating the possibility of conducting dust having entered into the calorimeter with the flowing liquid. In order to try to improve this situation, the calorimeter was emptied and filled again, but this time by condensating the argon instead of flowing it in liquid phase. The new High Voltage tests are not showing any significant improvement but the situation is statisfactory for ATLAS runn...

  7. Performance of a Rain Barrel Sharing Network under Climate Change

    Directory of Open Access Journals (Sweden)

    Seong Jin Noh

    2015-07-01

    Full Text Available Rain barrels can be technically shared through social practices or mutual agreement between individual households. This study proposes the evaluation system for a rain barrel sharing network (RBSN considering three performance criteria of reliability, resiliency, and vulnerability, under plausible climate change scenarios. First, this study shows how the system can be improved in terms of the performance criteria using historical daily rainfall data based on the storage-reliability-yield relationship. This study then examined how the benefits from RBSN are affected by climate change after 100 years. Three climate change scenarios (A1B, A2 and B2 and three global circulation models were used for this purpose. The results showed that the reliability and vulnerability are improved due to sharing and their improvements become larger under climate change conditions. In contrast, the resiliency reduces slightly due to sharing and its reduction is attenuated under climate change conditions. In particular, vulnerability will be reduced significantly under climate change. These results suggest that the sharing of various water resources systems can be an effective climate change adaptation strategy that reduces vulnerability and increases the reliability of the system.

  8. The EB factory project. II. Validation with the Kepler field in preparation for K2 and TESS

    Energy Technology Data Exchange (ETDEWEB)

    Parvizi, Mahmoud; Paegert, Martin; Stassun, Keivan G., E-mail: mahmoud.parvizi@vanderbilt.edu [Department of Physics and Astronomy, Vanderbilt University, VU Station B 1807, Nashville, TN 37235 (United States)

    2014-12-01

    Large repositories of high precision light curve data, such as the Kepler data set, provide the opportunity to identify astrophysically important eclipsing binary (EB) systems in large quantities. However, the rate of classical “by eye” human analysis restricts complete and efficient mining of EBs from these data using classical techniques. To prepare for mining EBs from the upcoming K2 mission as well as other current missions, we developed an automated end-to-end computational pipeline—the Eclipsing Binary Factory (EBF)—that automatically identifies EBs and classifies them into morphological types. The EBF has been previously tested on ground-based light curves. To assess the performance of the EBF in the context of space-based data, we apply the EBF to the full set of light curves in the Kepler “Q3” Data Release. We compare the EBs identified from this automated approach against the human generated Kepler EB Catalog of ∼2600 EBs. When we require EB classification with ⩾90% confidence, we find that the EBF correctly identifies and classifies eclipsing contact (EC), eclipsing semi-detached (ESD), and eclipsing detached (ED) systems with a false positive rate of only 4%, 4%, and 8%, while complete to 64%, 46%, and 32%, respectively. When classification confidence is relaxed, the EBF identifies and classifies ECs, ESDs, and EDs with a slightly higher false positive rate of 6%, 16%, and 8%, while much more complete to 86%, 74%, and 62%, respectively. Through our processing of the entire Kepler “Q3” data set, we also identify 68 new candidate EBs that may have been missed by the human generated Kepler EB Catalog. We discuss the EBF's potential application to light curve classification for periodic variable stars more generally for current and upcoming surveys like K2 and the Transiting Exoplanet Survey Satellite.

  9. An analysis of increasing the size of the strategic petroleum reserve to one billion barrels

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    The Department of Energy's Office of Energy Emergency Policy and Evaluation requested that the Energy Information Administration complete an analysis of the proposed expansion in the Strategic Petroleum Reserve (SPR) from its currently planned size of 750 million barrels to 1000 million barrels. Because the SPR contains only 580 million barrels at this point in time, the benefits and costs of increasing the SPR from 600 to 750 million barrels were also estimated. This report documents the assumptions, methodology, and results of the analysis. 17 figs., 15 tabs.

  10. The Integration and Abstracyion of EBS Models in Yucca Mountain Performance Assessment

    Energy Technology Data Exchange (ETDEWEB)

    S.D. Sevougian; V. Jain; A.V. Luik

    2006-01-11

    The safety strategy for geological disposal of radioactive waste at Yucca Mountain relies on a multi-barrier system to contain the waste and isolate it from the biosphere. The multi-barrier system consists of the natural barrier provided by the geological setting and the engineered barrier system (EBS). In the case of Yucca Mountain (YM) the geologic setting is the unsaturated-zone host rock, consisting of about 600 meters of layered ash-flow volcanic tuffs above the water table, and the saturated zone beneath the water table. Both the unsaturated and saturated rocks are part of a closed hydrologic basin in a desert surface environment. The waste is to be buried about halfway between the desert surface and the water table. The primary engineered barriers at YM consist of metal components that are highly durable in an oxidizing environment. The two primary components of the engineered barrier system are highly corrosion-resistant metal waste packages, made from a nickel-chromium-molybdenum alloy, Alloy 22, and titanium drip shields that protect the waste packages from corrosive dripping water and falling rocks. Design and performance assessment of the EBS requires models that describe how the EBS and near field behave under anticipated repository-relevant conditions. These models must describe coupled hydrologic, thermal, chemical, and mechanical (THCM) processes that drive radionuclide transport in a highly fractured host rock, consisting of a relatively permeable network of conductive fractures in a setting of highly impermeable tuff rock matrix. An integrated performance assessment of the EBS must include a quantification of the uncertainties that arise from (1) incomplete understanding of processes and (2) from lack of data representative of the large spatial scales and long time scales relevant to radioactive waste disposal (e.g., long-term metal corrosion rates and heterogeneities in rock properties over the large 5 km{sup 2} emplacement area of the repository

  11. Performance of the ATLAS electromagnetic calorimeter barrel module 0

    International Nuclear Information System (INIS)

    The construction and performance of the barrel pre-series module 0 of the future ATLAS electromagnetic calorimeter at the LHC is described. The signal reconstruction and performance of ATLAS-like electronics has been studied. The signal to noise ratio for muons has been found to be 7.11±0.07. An energy resolution of better than 9.5% GeV1/2/√E (sampling term) has been obtained with electron beams of up to 245 GeV. The uniformity of the response to electrons in an area of ΔηxΔphi=1.2x0.075 has been measured to be better than 0.8%

  12. Alcohol dehydrogenase polymorphism in barrel cactus populations of Drosophila mojavensis.

    Science.gov (United States)

    Cleland, S; Hocutt, G D; Breitmeyer, C M; Markow, T A; Pfeiler, E

    1996-07-01

    Starch gel electrophoresis revealed that the alcohol dehydrogenase (ADH-2) locus was polymorphic in two populations (from Agua Caliente, California and the Grand Canyon, Arizona) of cactophilic Drosophila mojavensis that utilize barrel cactus (Ferocactus acanthodes) as a host plant. Electromorphs representing products of a slow (S) and a fast (F) allele were found in adult flies. The frequency of the slow allele was 0.448 in flies from Agua Caliente and 0.659 in flies from the Grand Canyon. These frequencies were intermediate to those of the low (Baja California peninsula, Mexico) and high (Sonora, Mexico and southern Arizona) frequency Adh-2S populations of D. mojavensis that utilize different species of host cacti. PMID:8765684

  13. Charged Pion Energy Reconstruction in the ATLAS Barrel Calorimeter

    CERN Document Server

    Bosman, M; Nessi, Marzio

    2000-01-01

    The intrinsic performance of the ATLAS barrel and extended barrelcalorimeters for the measurement of charged pions is presented. Pion energyscans (E = 20, 50, 200, 400 and 1000 GeV) at two pseudo-rapidity points ($\\eta$= 0.3 and 1.3) and pseudorapidity scans ($-0.2 < \\eta < 1.8$) with pions ofconstant transverse energy ($E_T = 20$ and 50 GeV) are analysed. A simpleapproach, that accounts in first order for non-compensation and dead materialeffects, is used for the pion energy reconstruction. The intrinsic performancesof the calorimeter are studied: resolution, linearity, effect of dead material,tails in the energy distribution. The effect of electronic noise, cell energycuts and restricted cone size are investigated.

  14. Performance of the ATLAS electromagnetic calorimeter barrel module 0

    CERN Document Server

    Aubert, Bernard; Alexa, C; Astesan, F; Augé, E; Aulchenko, V M; Ballansat, J; Barreiro, F; Barrillon, P; Battistoni, G; Bazan, A; Beaugiraud, B; Beck-Hansen, J; Belhorma, B; Belorgey, J; Belymam, A; Ben-Mansour, A; Benchekroun, D; Benchouk, C; Bernard, R; Bertoli, W; Boniface, J; Bonivento, W; Bourdarios, C; Bremer, J; Breton, D; Bán, J; Camard, A; Canton, B; Carminati, L; Cartiglia, N; Cavalli, D; Chalifour, M; Chekhtman, A; Chen, H; Cherkaoui, R; Chevalley, J L; Chollet, F; Citterio, M; Clark, A; Cleland, W; Clément, C; Colas, Jacques; Collot, J; Costa, G; Cros, P; Cunitz, H; de Saintignon, P; Del Peso, J; Delebecque, P; Delmastro, M; Di Ciaccio, Lucia; Dinkespiler, B; Djama, F; Dodd, J; Driouichi, C; Dumont-Dayot, N; Duval, P Y; Dzahini, D; Efthymiopoulos, I; Egdemir, J; El-Kacimi, M; El-Mouahhidi, Y; Engelmann, R; Ernwein, J; Falleau, I; Fanti, M; Farrell, J; Fassnacht, P; Ferrari, A; Fichet, S; Fournier, D; Gallin-Martel, M L; Gara, A; García, G; Gaumer, O; Ghazlane, H; Ghez, P; Gianotti, F; Girard, C; Gordon, H; Gouanère, M; Guilhem, G; Hackenburg, B; Hakimi, M; Hassani, S; Henry-Coüannier, F; Hervás, L; Hinz, L; Hoffman, A; Hoffman, J; Hostachy, J Y; Hoummada, A; Hubaut, F; Idrissi, A; Imbault, D; Jacquier, Y; Jérémie, A; Jevaud, M; Jézéquel, S; Kambara, H; Karst, P; Kazanin, V; Kierstead, J A; Kolachev, G M; Kordas, K; de La Taille, C; Labarga, L; Lacour, D; Lafaye, R; Laforge, B; Lanni, F; Le Coroller, A; Le Dortz, O; Le Maner, C; Le Van-Suu, A; Le Flour, T; Leite, M; Leltchouk, M; Lesueur, J; Lissauer, D; Lund-Jensen, B; Lundqvist, J M; Ma, H; Macé, G; Makowiecki, D S; Malychev, V; Mandelli, L; Mansoulié, B; Marin, C P; Martin, D; Martin, L; Martin, O; Martin, P; Maslennikov, A L; Massol, N; Mazzanti, M; McCarthy, R; McDonald, J; Megner, L; Merkel, B; Mirea, A; Moneta, L; Monnier, E; Moynot, M; Muraz, J F; Nagy, E; Negroni, S; Neukermans, L; Nicod, D; Nikolic-Audit, I; Noppe, J M; Ohlsson-Malek, F; Olivier, C; Orsini, F; Pailler, P; Parrour, G; Parsons, J A; Pearce, M; Perini, L; Perrodo, P; Perrot, G; Pétroff, P; Poggioli, Luc; Pospelov, G E; Pralavorio, Pascal; Prast, J; Przysiezniak, H; Puzo, P; Radeka, V; Rahm, David Charles; Rajagopalan, S; Raymond, M; Renardy, J F; Repetti, B; Rescia, S; Resconi, S; Riccadona, X; Richer, J P; Rijssenbeek, M; Rodier, S; Rossel, F; Rousseau, D; Rydström, S; Saboumazrag, S; Sauvage, D; Sauvage, G; Schilly, P; Schwemling, P; Schwindling, J; Seguin-Moreau, N; Seidl, W; Seman, M; Serin, L; Shousharo, A; Simion, S; Sippach, W; Snopkov, R; Steffens, J; Stroynowski, R; Stumer, I; Taguet, J P; Takai, H; Talyshev, A A; Tartarelli, F; Teiger, J; Thion, J; Tikhonov, Yu A; Tisserant, S; Tocut, V; Tóth, J; Veillet, J J; Vossebeld, Joost Herman; Vuillemin, V; Wielers, M; Willis, W J; Wingerter-Seez, I; Ye, J; Yip, K; Zerwas, D; Zitoun, R; Zolnierowski, Y

    2003-01-01

    The construction and performance of the barrel pre-series module 0 of the future ATLAS electromagnetic calorimeter at the LHC is described. The signal reconstruction and performance of ATLAS-like electronics has been studied. The signal to noise ratio for muons has been found to be 7.11+-0.07. An energy resolution of better than 9.5% GeV^1/2/sqrt{E} (sampling term) has been obtained with electron beams of up to 245GeV. The uniformity of the response to electrons in an area of Delta_eta x Delta_phi = 1.2 x 0.075 has been measured to be better than 0.8%.

  15. A hybrid magnetostrictive-piezoelectric barrel-stave projector

    Institute of Scientific and Technical Information of China (English)

    CHAI Yong; MO Xiping; LIU Yongping; CUI Zheng

    2006-01-01

    A hybrid magnetostrictive-piezoelectric barrel-stave projector is designed and developed. The new type transducer is driven by the union of rare-earth giant magnetostrictive material Terfenol-D and PZT piezoelectric ceramic. Combining the advantages of low frequency performance within a compact size, it proves that the hybrid projector has a much broader band and higher sound power than that with single magnetostrictive or piezoelectric driver by the simulated and measured results. The prototype of the hybrid projector has a size of 88 mm in outside diameter and 316 mm in length, with an underwater resonant frequency of 1.30 kHz,Q factor of 1.43 for -3 dB bandwidth, and transmitting voltage response level of 135.1 dB at the resonant frequency.

  16. Modeling of gun barrel surface erosion: Historic perspective

    Energy Technology Data Exchange (ETDEWEB)

    Buckingham, A.C.

    1996-08-01

    Results and interpretations of numerical simulations of some dominant processes influencing gun barrel propellant combustion and flow-induced erosion are presented. Results include modeled influences of erosion reduction techniques such as solid additives, vapor phase chemical modifications, and alteration of surface solid composition through use of thin coatings. Precedents and historical perspective are provided with predictions from traditional interior ballistics compared to computer simulations. Accelerating reactive combustion flow, multiphase and multicomponent transport, flow-to-surface thermal/momentum/phase change/gas-surface chemical exchanges, surface and micro-depth subsurface heating/stress/composition evolution and their roles in inducing surface cracking, spall, ablation, melting, and vaporization are considered. Recognition is given to cyclic effects of previous firing history on material preconditioning. Current perspective and outlook for future are based on results of a US Army-LLNL erosion research program covering 7 y in late 1970s. This is supplemented by more recent research on hypervelocity electromagnetic projectile launchers.

  17. The CMS Level-1 Trigger Barrel Track Finder

    CERN Document Server

    Ero, Janos; Ioannis Flouris; Fountas, Konstantinos; Guiducci, Luigi; Loukas, Nikitas; Manthos, Nikolaos; Papadopoulos, Ioannis; Paradas, Evangelos; Triossi, Andrea; Wulz, Claudia

    2015-01-01

    The design and performance of the upgraded CMS Level-1 Trigger Barrel Muon Track Finder (BMTF) is presented. Monte Carlo simulation data as well as cosmic ray and pp data from a CMS muon detector slice test have been used to study in detail the performance of the new track finder. The design architecture is based on twelve MP7 cards which use a Xilinx Virtex-7 FPGA and can receive and transmit data at 10 Gbps from 72 input and 72 output fibers. According to the CMS Trigger Upgrade TDR the BMTF receives trigger primitive data which are computed using both RPC and DT data and transmits data from a number of muon candidates to the upgraded Global Muon Trigger. Results from detailed studies of comparisons between the BMTF algorithm results and the results of a C++ emulator are also presented. The new BMTF will be commissioned for data taking in 2016.

  18. Important contribution of the novel locus comEB to extracellular DNA-dependent Staphylococcus lugdunensis biofilm formation.

    Science.gov (United States)

    Rajendran, Nithya Babu; Eikmeier, Julian; Becker, Karsten; Hussain, Muzaffar; Peters, Georg; Heilmann, Christine

    2015-12-01

    The coagulase-negative species Staphylococcus lugdunensis is an emerging cause of serious and potentially life-threatening infections, such as infective endocarditis. The pathogenesis of these infections is characterized by the ability of S. lugdunensis to form biofilms on either biotic or abiotic surfaces. To elucidate the genetic basis of biofilm formation in S. lugdunensis, we performed transposon (Tn917) mutagenesis. One mutant had a significantly reduced biofilm-forming capacity and carried a Tn917 insertion within the competence gene comEB. Site-directed mutagenesis and subsequent complementation with a functional copy of comEB verified the importance of comEB in biofilm formation. In several bacterial species, natural competence stimulates DNA release via lysis-dependent or -independent mechanisms. Extracellular DNA (eDNA) has been demonstrated to be an important structural component of many bacterial biofilms. Therefore, we quantified the eDNA in the biofilms and found diminished eDNA amounts in the comEB mutant biofilm. High-resolution images and three-dimensional data obtained via confocal laser scanning microscopy (CSLM) visualized the impact of the comEB mutation on biofilm integrity. The comEB mutant did not show reduced expression of autolysin genes, decreased autolytic activities, or increased cell viability, suggesting a cell lysis-independent mechanism of DNA release. Furthermore, reduced amounts of eDNA in the comEB mutant biofilms did not result from elevated levels or activity of the S. lugdunensis thermonuclease NucI. In conclusion, we defined here, for the first time, a role for the competence gene comEB in staphylococcal biofilm formation. Our findings indicate that comEB stimulates biofilm formation via a lysis-independent mechanism of DNA release.

  19. Grafting PNIPAAm from β-barrel shaped transmembrane nanopores.

    Science.gov (United States)

    Charan, Himanshu; Kinzel, Julia; Glebe, Ulrich; Anand, Deepak; Garakani, Tayebeh Mirzaei; Zhu, Leilei; Bocola, Marco; Schwaneberg, Ulrich; Böker, Alexander

    2016-11-01

    The research on protein-polymer conjugates by grafting from the surface of proteins has gained significant interest in the last decade. While there are many studies with globular proteins, membrane proteins have remained untouched to the best of our knowledge. In this study, we established the conjugate formation with a class of transmembrane proteins and grow polymer chains from the ferric hydroxamate uptake protein component A (FhuA; a β-barrel transmembrane protein of Escherichia coli). As the lysine residues of naturally occurring FhuA are distributed over the whole protein, FhuA was reengineered to have up to 11 lysines, distributed symmetrically in a rim on the membrane exposed side (outside) of the protein channel and exclusively above the hydrophobic region. Reengineering of FhuA ensures a polymer growth only on the outside of the β-barrel and prevents blockage of the channel as a result of the polymerization. A water-soluble initiator for controlled radical polymerization (CRP) was consecutively linked to the lysine residues of FhuA and N-isopropylacrylamide (NIPAAm) polymerized under copper-mediated CRP conditions. The conjugate formation was analyzed by using MALDI-ToF mass spectrometry, SDS-PAGE, circular dichroism spectroscopy, analytical ultracentrifugation, dynamic light scattering, transmission electron microscopy and size exclusion chromatography. Such conjugates combine the specific functions of the transmembrane proteins, like maintaining membrane potential gradients or translocation of substrates with the unique properties of synthetic polymers such as temperature and pH stimuli handles. FhuA-PNIPAAm conjugates will serve as functional nanosized building blocks for applications in targeted drug delivery, self-assembly systems, functional membranes and transmembrane protein gated nanoreactors. PMID:27614163

  20. Design and development of a work robot to place ATLAS SCT modules onto barrel cylinders

    CERN Document Server

    Terada, S; Honma, F; Ikegami, Y; Iwata, Y; Kato, Y; Kobayashi, H; Kohriki, T; Kondo, T; Nakano, I; Sengoku, H; Takashima, R; Tanaka, R; Ujiie, N; Unno, Y; Yasuda, S

    2005-01-01

    More than 2000 silicon modules need to be placed and fastened on the ATLAS SCT barrel tracker. A semi-automatic pick-and-place work robot was designed and developed to cope with the module placement for the SCT barrel assembly. We found that this robot could place modules to a mechanical precision of better than 25 mum.

  1. Thermal cycling behaviour of lanthanum zirconate as EB-PVD thermal barrier coating

    International Nuclear Information System (INIS)

    Thermal cycling tests with two different EB-PVD thermal barrier coatings (TBC) were performed in a furnace cycle test. The results of these tests showed an increase of endurable cycle number when pyrochloric La2Zr2O7 was used as TBC. 1865 cycles were reached with La2Zr2O7 and 1380 cycles with 7 weigth-% yttria stabilised zirconia (YSZ) EB-PVD TBC. Additional investigation was made with scanning electron microscope (SEM) to investigate morphology and to determine chemical composition by electron dispersive x-ray spectroscopy (EDS) analysis. X-Ray diffraction was performed to analyze structural constitution of deposited coatings. (Abstract Copyright [2006], Wiley Periodicals, Inc.)

  2. Influence of surface modification on isothermal oxidation behavior of EB-PVD NiAl coating

    Institute of Scientific and Technical Information of China (English)

    LI He-fei; TAO Shu-feng; JIANG Kuo; A. HESNAWI; GONG Sheng-kai

    2006-01-01

    The isothermal oxidation behaviors of the as-deposited NiAl coating on the nickel-based superalloy by electron beam physical vapour deposition(EB-PVD) and the NiAl coating after surface modifications of grinding and polishing were investigated. The as-deposited coating shows the least mass gain, the initially formed θ-Al2O3 scale spalls after only 1 h, and the succeeding scale formed is coarse and discontinuous and thus can not be used as protective coatings. Among the two surface-modified coatings, the ground coating results in the highest oxide growth rate, which is consistent with the SEM results where the scale spalls heavily and many voids appear between the scale and the NiAl coating. The scale spallation and void formation mechanisms during isothermal oxidation test of EB-PVD NiAl coating were also discussed.

  3. A Dynamic Self-Healing Key Management Scheme for Wireless Sensor Networks Based on EBS

    Directory of Open Access Journals (Sweden)

    Jaunting Ning

    2013-01-01

    Full Text Available A self-healing mechanism in key management is an important means for large-scale clustering wireless sensor networks that enable non-revoked nodes use their private information and the received broadcast messages to recover the lost session keys on their own. In this study, we propose a dynamic self-healing key management scheme for large-scale clustering wireless sensor networks that is based on Exclusion Basis System (EBS. We use forward and backward key chains to form cluster session key chain for self-healing, take t-degree polynomial keys to replace the original keys used in EBS. The analysis shows that the proposed scheme has the properties of forward and backward secrecy and resisting to a collusion attack, which is suitable for resource-constrained wireless sensor networks.

  4. Research of Register and Federal Query based ebXML R/R%基于ebXML R/R注册与联合查询的研究

    Institute of Scientific and Technical Information of China (English)

    夏显鄂; 窦竹梅; 朱兴国

    2011-01-01

    研究ebXML R/R的规范,元数据服务类似于图书馆管理,概括ebXML R/R模型和接口协议原理.完成元数据注册中心的实现方案,以ebXML R/R为后台服务端建立元数据注册中心,客户端运行于Web应用服务器,提出以压缩包zip文件和xml描述文件的方法提交元数据的方式,将提交论文数据库元数据为例加以说明.描述与ebXML R/R服务端的交互、注册服务和联合查询的程序步骤、执行方式和机理.%ebXML R/R Specifications were studied. Metadata service was similar with library management. Information models and interfaces, protocols were generalized. Metadata registry center was implemented, an ebXML R/R server as background, an ebXML R/R client running on the Web application server. The methods of submitting metadata with zip package and xml file were put forward, and explained by the example of submitting the paper database metadata. Program step, performing manner and mechanism of interacting with the ebXML R/R server, registering service and federal query were described.

  5. Microtubule-Associated Protein EB3 Regulates IP3 Receptor Clustering and Ca2+ Signaling in Endothelial Cells

    Directory of Open Access Journals (Sweden)

    Melissa Geyer

    2015-07-01

    Full Text Available The mechanisms by which the microtubule cytoskeleton regulates the permeability of endothelial barrier are not well understood. Here, we demonstrate that microtubule-associated end-binding protein 3 (EB3, a core component of the microtubule plus-end protein complex, binds to inositol 1,4,5-trisphosphate receptors (IP3Rs through an S/TxIP EB-binding motif. In endothelial cells, α-thrombin, a pro-inflammatory mediator that stimulates phospholipase Cβ, increases the cytosolic Ca2+ concentration and elicits clustering of IP3R3s. These responses, and the resulting Ca2+-dependent phosphorylation of myosin light chain, are prevented by depletion of either EB3 or mutation of the TxIP motif of IP3R3 responsible for mediating its binding to EB3. We also show that selective EB3 gene deletion in endothelial cells of mice abrogates α-thrombin-induced increase in endothelial permeability. We conclude that the EB3-mediated interaction of IP3Rs with microtubules controls the assembly of IP3Rs into effective Ca2+ signaling clusters, which thereby regulate microtubule-dependent endothelial permeability.

  6. Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity

    Energy Technology Data Exchange (ETDEWEB)

    Marreilha dos Santos, A.P., E-mail: apsantos@ff.ul.pt [I-Med.UL, Department of Toxicology and Food Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon (Portugal); Lucas, Rui L.; Andrade, Vanda; Mateus, M. Luísa [I-Med.UL, Department of Toxicology and Food Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon (Portugal); Milatovic, Dejan; Aschner, Michael [Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Batoreu, M. Camila [I-Med.UL, Department of Toxicology and Food Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon (Portugal)

    2012-02-01

    Chronic, excessive exposure to manganese (Mn) may induce neurotoxicity and cause an irreversible brain disease, referred to as manganism. Efficacious therapies for the treatment of Mn are lacking, mandating the development of new interventions. The purpose of the present study was to investigate the efficacy of ebselen (Ebs) and para-aminosalicylic acid (PAS) in attenuating the neurotoxic effects of Mn in an in vivo rat model. Exposure biomarkers, inflammatory and oxidative stress biomarkers, as well as behavioral parameters were evaluated. Co-treatment with Mn plus Ebs or Mn plus PAS caused a significant decrease in blood and brain Mn concentrations (compared to rats treated with Mn alone), concomitant with reduced brain E{sub 2} prostaglandin (PGE{sub 2}) and enhanced brain glutathione (GSH) levels, decreased serum prolactin (PRL) levels, and increased ambulation and rearing activities. Taken together, these results establish that both PAS and Ebs are efficacious in reducing Mn body burden, neuroinflammation, oxidative stress and locomotor activity impairments in a rat model of Mn-induced toxicity. -- Highlights: ► The manuscript is unique in its approach to the neurotoxicity of Mn. ► The manuscript incorporates molecular, cellular and functional (behavioral) analyses. ► Both PAS and Ebs are effective in restoring Mn behavioral function. ► Both PAS and Ebs are effective in reducing Mn-induced oxidative stress. ► Both PAS and Ebs led to a decrease in Mn-induced neuro-inflammation.

  7. Dynamics of inner ear pressure release, measured with a double-barreled micropipette in the guinea pig

    NARCIS (Netherlands)

    Wit, HP; Thalen, EO; Albers, FWJ

    1999-01-01

    The inner ear, fluid pressure was measured in scala media of the guinea pig through one barrel of a double-barreled micropipette after a sudden volume increase or decrease, caused by injection or withdrawal of artificial endolymph through the other barrel. During injection or withdrawal, the inner e

  8. Structural insight into the biogenesis of β-barrel membrane proteins.

    Science.gov (United States)

    Noinaj, Nicholas; Kuszak, Adam J; Gumbart, James C; Lukacik, Petra; Chang, Hoshing; Easley, Nicole C; Lithgow, Trevor; Buchanan, Susan K

    2013-09-19

    β-barrel membrane proteins are essential for nutrient import, signalling, motility and survival. In Gram-negative bacteria, the β-barrel assembly machinery (BAM) complex is responsible for the biogenesis of β-barrel membrane proteins, with homologous complexes found in mitochondria and chloroplasts. Here we describe the structure of BamA, the central and essential component of the BAM complex, from two species of bacteria: Neisseria gonorrhoeae and Haemophilus ducreyi. BamA consists of a large periplasmic domain attached to a 16-strand transmembrane β-barrel domain. Three structural features shed light on the mechanism by which BamA catalyses β-barrel assembly. First, the interior cavity is accessible in one BamA structure and conformationally closed in the other. Second, an exterior rim of the β-barrel has a distinctly narrowed hydrophobic surface, locally destabilizing the outer membrane. And third, the β-barrel can undergo lateral opening, suggesting a route from the interior cavity in BamA into the outer membrane. PMID:23995689

  9. Charged Pion Energy Reconstruction in the ATLAS Barrel Calorimeter

    CERN Document Server

    Bosman, Martine; Nessi, Marzio

    1999-01-01

    Intrinsic performance of the ATLAS calorimeters in the barrel region with respect to charged pions was studied. For this the following simulated data were used: pion energy scans ($E = 20, 50, 200, 400$ and $1000$ GeV) at two pseudo-rapidity points ($eta = 0.3$ and $1.3$) and pseudo-rapidity scans ($-0.2 < eta < 1.8$) with pions of constant transverse energy ($E_T = 20$ and $50$ GeV). For pion energy reconstruction the benchmark approach was used. Performance was estimated for cases, when energy and rapidity dependent and independent calibration parameters were applied. The best results were obtained with energy and rapidity dependent parameters. Studies done for pions enabled optimization of the cone size and of the cut to obtain the best energy resolution. Energy dependence of the resolution can be parameterized as: $(50pm4)%/sqrt{E} oplus (3.4pm0.3)% oplus 1.0/E$ at $eta = 0.3$ and $(68pm8)%/sqrt{E} oplus (3.0pm0.7)% oplus 1.5/E$ at $eta = 1.3$. Larger constant term at $eta=0.3$ can be explained by l...

  10. Double Barreled Wet Colostomy: Initial Experience and Literature Review

    Directory of Open Access Journals (Sweden)

    Luis Salgado-Cruz

    2014-01-01

    Full Text Available Background. Pelvic exenteration and multivisceral resection in colorectal have been described as a curative and palliative intervention. Urinary tract reconstruction in a pelvic exenteration is achieved in most cases with an ileal conduit of Bricker, although different urinary reservoirs have been described. Methods. A retrospective and observational study of six patients who underwent a pelvic exenteration and urinary tract reconstruction with a double barreled wet colostomy (DBWC was done, describing the preoperative diagnosis, the indication for the pelvic exenteration, the complications associated with the procedure, and the followup in a period of 5 years. A literature review of the case series reported of the technique was performed. Results. Six patients had a urinary tract reconstruction with the DBWC technique, 5 male patients and one female patient. Age range was from 20 to 77 years, with a medium age 53.6 years. The most frequent complication presented was a pelvic abscess in 3 patients (42.85%; all complications could be resolved with a conservative treatment. Conclusion. In the group of our patients with pelvic exenteration and urinary tract reconstruction with a DBWC, it is a safe procedure and well tolerated by the patients, and most of the complications can be resolved with conservative treatment.

  11. Erosion measurement techniques for plasma-driven railgun barrels

    Energy Technology Data Exchange (ETDEWEB)

    Jamison, K.A.; Niiler, A.

    1987-04-01

    Plasma-driven railguns are now in operation at several locations throughout the world. All share common problems in barrel erosion arising from the fact that the bore surface must contain a high temperature plasma armature which transmits the acceleration force to a projectile. The plasma temperature at the core of the armature is estimated to be 30 000 K or higher. Such conditions are erosive to most materials even when the exposure time is 100 s or less. We have adapted two accelerator based techniques to aid in the study of this erosion. The first technique involves the collection and analysis of material ablated and left behind by the plasma. This analysis is baded on the unfolding of the Rutherford backscattered (RBS) spectra of 1 MeV deuterons incident on residue collected from a railgun bore. The second technique is an erosion measurement involving thin layer activation (TLA) of surfaces. In this process, the copper rail surface is activated by 2.4 MeV protons creating a relatively thin (3 m) layer sparsely seeded with a long lived zinc isotope. Monitoring the decay of the activated sample before and after a firing can detect surface wear of about 0.1 m. Results from the RBS and TLA experiments on the BRL plasma driven railgun are described.

  12. Erosion measurement techniques for plasma-driven railgun barrels

    Energy Technology Data Exchange (ETDEWEB)

    Jamison, K.A.; Niiler, A.

    1987-04-01

    Plasma-driven railguns are now in operation at several locations throughout the world. All share common problems in barrel erosion arising from the fact that the bore surface must contain a high temperature plasma armature which transmits the acceleration force to a projectile. The plasma temperature at the core of the armature is estimated to be 30 000 K or higher. Such conditions are erosive to most materials even when the exposure time is 100 ..mu..s or less. We have adapted two accelerator based techniques to aid in the study of this erosion. The first technique involves the collection and analysis of material ablated and left behind by the plasma. This analysis is baded on the unfolding of the Rutherford backscattered (RBS) spectra of 1 MeV deuterons incident on residue collected from a railgun bore. The second technique is an erosion measurement involving thin layer activation (TLA) of surfaces. In this process, the copper rail surface is activated by 2.4 MeV protons creating a relatively thin (3 ..mu..m) layer sparsely seeded with a long lived zinc isotope. Monitoring the decay of the activated sample before and after a firing can detect surface wear of about 0.1 ..mu..m. Results from the RBS and TLA experiments on the BRL plasma driven railgun are described.

  13. First ATLAS Barrel Toroid coil casing arrives at CERN

    CERN Multimedia

    2002-01-01

    The first of eight 25-metre long coil casings for the ATLAS experiment's barrel toroid magnet system arrived at CERN on Saturday 2 March by road from Heidelberg. This structure will be part of the largest superconducting toroid magnet ever made.   The first coil casing for the toroidal magnets of Atlas arrives at Building 180. This is the start of an enormous three-dimensional jigsaw puzzle. Each of the eight sets of double pancake coils will be housed inside aluminium coil casings, which in turn will be held inside a stainless steel vacuum vessel. A huge construction, the casing that arrived at CERN measures 25 metres in length and 5 metres in width. It weighs 20 tones. And this is just the beginning of the toroid jigsaw: by early April a batch of four double pancake coils, which altogether weighs 65 tones, will arrive from Ansaldo in Italy. The first vacuum vessel will also be arriving from Felguera in Spain this month. It will take about two years for all these 25 m long structures of casings, coils a...

  14. Cryogenic Characteristics of the ATLAS Barrel Toroid Superconducting Magnet

    CERN Document Server

    Pengo, R; Delruelle, N; Pezzetti, M; Pirotte, O; Passardi, Giorgio; Dudarev, A; ten Kate, H

    2008-01-01

    ATLAS, one of the experiments of the LHC accelerator under commissioning at CERN, is equipped with a large superconducting magnet the Barrel Toroid (BT) that has been tested at nominal current (20500 A). The BT is composed of eight race-track superconducting coils (each one weights about 45 tons) forming the biggest air core toroidal magnet ever built. By means of a large throughput centrifugal pump, a forced flow (about 10 liter/second at 4.5 K) provides the indirect cooling of the coils in parallel. The paper describes the results of the measurements carried out on the complete cryogenic system assembled in the ATLAS cavern situated 100 m below the ground level. The measurements include, among other ones, the static heat loads, i.e., with no or constant current in the magnet, and the dynamic ones, since additional heat losses are produced, during the current ramp-up or slow dump, by eddy currents induced on the coil casing.

  15. Performance of prototypes for the PANDA barrel EMC

    Science.gov (United States)

    Bremer, D. A.; Eissner, T.; Drexler, P.; Moritz, M.; Novotny, R. W.; PANDA Collaboration

    2015-02-01

    The PANDA experiment will be part of the future Facility for Antiproton and Ion Research (FAIR) and aims for the study of strong interaction within the charm sector via antiproton proton collisions up to antiproton momenta of 15 GeV/c. Reflecting the variety of the physics program the PANDA detector is designed as a multi-purpose detector able to perform tracking, calorimetry and particle identification with nearly complete coverage of the solid angle. The Electromagnetic Calorimeter (EMC) contained inside its Target Spectrometer is based on cooled PbWO4 scintillator crystals. In order to ensure an excellent performance throughout the large dynamic range of photon/electron energies ranging from a few MeV up to 15 GeV an extensive prototyping phase is mandatory. This contribution describes the measured response of the EMC barrel part prototype PROTO60 at the largest design energy to secondary beams provided by the SPS at CERN. In addition to PROTO60 a tracking station was deployed, providing precise position information of the 15 GeV/c positrons. For calibration purposes a 150 GeV/c muon beam and cosmic radiation, in combination with estimations from GEANT4 simulations were used. The obtained performance concerning energy, position and time information is presented.

  16. Study of the EM Barrel Module 0 with muons

    CERN Document Server

    Camard, A; Laforge, B; Schwemling, P

    2001-01-01

    Muons contaminating the high energy electron beam have been used to study the EM barrel module~0 response to ''minimum ionising'' particles. The ratio between the muon signal and the noise reaches 7.11$\\pm$0.07 when only the middle sampling information are used and reconstructed with an optimal filtering method. The latter increases this ratio by a factor 1.8 with respect to a raw conversion between ADC counts and GeV. From an absolute energy measurement, a $\\left( \\frac{\\mathrm{e}}{\\mathrm{\\mu}} \\right)$ ratio of $0.75\\pm0.02$ is derived. As muons deposit their energy in a smaller cluster than the electrons, they can provide cleaner or complementary information on the calorimeter. For example, the modulation of a cell response with~$\\Phi$ is larger than with electrons, the modulation in the latter case being smoothed out by the transverse size of the electromagnetic showers. Unlike electrons, muons provide also a mean to test the crosstalk measurements done with calibration runs. A good agreement is found. A...

  17. Barrel Toroid fully charged to nominal field, and it works!

    CERN Multimedia

    Herman ten Kate

    After a few weeks of testing up to intermediate currents, finally, on Thursday evening November 9, the current in the Barrel Toroid was pushed up to its nominal value of 20500 A and even 500 A beyond this value to prove that we have some margin. It went surprisingly well. Of course, the 8 coils forming the toroid were already tested individually at the surface but still, some surprise may have come from those parts added to the toroid in the cavern for the first time like the 8 cryoring sections linking the coils as well as the valve box at the bottom in sector 13 regulating the helium flow or the current lead cryostat on the top in sector 5. No training quenches, nothing to worry about, and the test was concluded with a fast dump triggered at 00:40 in the very early morning of November 10. (left) The toroid current during the evening and night of November 9. (right) The test crew oscillated between fear and hope while looking at the control panels as the current approached 21kA. Big relief was in the...

  18. Second Barrel Toroid Coil Installed in ATLAS Cavern

    CERN Multimedia

    Tappern, G.

    The second barrel toroid coil was lowered into the ATLAS Cavern on Friday, 26 November. The operation takes approximately five hours of precision crane and winch operations. Before lowering, several checks are made to ensure that no loose items have been left on the coil which would fall during the lowering down the shaft. This is a very difficult, but very important check, with the first coil in position, and partly below the shaft. After changing the winch tooling on Wednesday December 1st, the coil was lifted, rotated and placed into the feet. The girders which support the coil and the Z direction stops had all been pre-set before putting the coil in the feet. The angle is controlled by an inclinometer. When the final adjustments of position have been made, which will locate the coils at the plus/minus two mm level, the connection beams (voussoirs and struts) will be put in place; this requires a complex shimming procedure. This will lock together the two coils into the feet and forms the foundation for th...

  19. Centrifugal barrel polishing of 1.3 GHz Nb cavities

    Energy Technology Data Exchange (ETDEWEB)

    Tamashevich, Yegor; Foster, Brian [DESY, Hamburg (Germany); Hamburg Univ. (Germany); Navitski, Aliaksandr; Steder, Lea; Elsen, Eckhard [DESY, Hamburg (Germany)

    2013-07-01

    Superconducting radio-frequency (SRF) cavities are the key components of particle accelerators such as the European X-ray Free Electron Laser (XFEL, under construction) and the planned future International Linear Collider (ILC). Steady progress in surface treatment techniques of SRF cavities in both the achievable quality factor Q and the accelerating electric field Eacc makes new accelerators and ambitious projects feasible. One of the alternative surface preparation techniques which is actually being explored is centrifugal barrel polishing (CBP) pioneered at KEK in Japan in mid-nineties by T. Hiuchi et al. CBP is a mechanical polishing of cavities and results in around 10 x smaller surface roughness and mirror-like surface as compared to chemistry alone. Q and E{sub acc} are expected to be at least as high as for chemically treated cavities. CBP eliminates the bulk chemistry and has the potential to completely replace the chemistry. The University of Hamburg is installing a CBP machine to study it as a cavity preparation and repair technique for 9-cell 1.3 GHz SRF cavities at the Deutsche Elektronen-Synchrotron (DESY). The setup and first commissioning tests will be presented and discussed.

  20. Modal analysis of an ECC duct for APR+ reactor barrel

    International Nuclear Information System (INIS)

    Advanced Power Reactor Plus (APR+) provides four Direct Vessel Injection (DVI) ducts on the reactor barrel to enhance the performance of Emergency Core Cooling System (ECCS). Several studies on safety analysis have verified the excellent performance of the DVI duct. In this study, from the viewpoint of mechanical integrity, modal analyses of two full-scaled DVI ducts have been presented; both numerical analysis and modal tests have been performed in air and water. It was found that the numerical simulation and modal test coincide with each other. The DVI duct is a thin shell of 5 mm thickness, so that harmonic responses to RCP blade passing frequencies should be checked. The dominant passing frequencies are known to be 20, 40, 60, 120 and 240 Hz. In addition, an interesting thing in this study is that added mass effect by coolant seems to be so significant that the natural frequency of the ducts under water could be considerably low as compared with those in air; the natural frequency under water is 60 % lower than that in air. (author)

  1. High Stimulus-Related Information in Barrel Cortex Inhibitory Interneurons.

    Directory of Open Access Journals (Sweden)

    Vicente Reyes-Puerta

    2015-06-01

    Full Text Available The manner in which populations of inhibitory (INH and excitatory (EXC neocortical neurons collectively encode stimulus-related information is a fundamental, yet still unresolved question. Here we address this question by simultaneously recording with large-scale multi-electrode arrays (of up to 128 channels the activity of cell ensembles (of up to 74 neurons distributed along all layers of 3-4 neighboring cortical columns in the anesthetized adult rat somatosensory barrel cortex in vivo. Using two different whisker stimulus modalities (location and frequency we show that individual INH neurons--classified as such according to their distinct extracellular spike waveforms--discriminate better between restricted sets of stimuli (≤6 stimulus classes than EXC neurons in granular and infra-granular layers. We also demonstrate that ensembles of INH cells jointly provide as much information about such stimuli as comparable ensembles containing the ~20% most informative EXC neurons, however presenting less information redundancy - a result which was consistent when applying both theoretical information measurements and linear discriminant analysis classifiers. These results suggest that a consortium of INH neurons dominates the information conveyed to the neocortical network, thereby efficiently processing incoming sensory activity. This conclusion extends our view on the role of the inhibitory system to orchestrate cortical activity.

  2. Analysis and control of welding deformation in nuclear reactor core barrel

    International Nuclear Information System (INIS)

    Core barrel is an important part in React Vessel Internals(RVI) and the design of tolerance is quite strict. Firstly, the paper analyses the reasons of welding deformation in core barrel and with the reasons, the paper presents control measures to solve welding deformation. Then, combining the severe deformation in the welding of core barrel in Qinshan Nuclear Power Phase II extension Project Reactor no.3 unit, the paper supply control measures to the no.4 unit and the result of weld satisfy the requirements and the result satisfy design requirement. (authors)

  3. A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules

    Energy Technology Data Exchange (ETDEWEB)

    Iimori, Makoto; Ozaki, Kanako [Graduate School of Biostudies, Kyoto University, Kitashirakawa-Oiwake cho, Sakyo ku, Kyoto, 606-8502 (Japan); Chikashige, Yuji [Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, Kobe, 651-2492 (Japan); Habu, Toshiyuki [Graduate School of Biostudies, Kyoto University, Kitashirakawa-Oiwake cho, Sakyo ku, Kyoto, 606-8502 (Japan); Radiation Biology Center, Kyoto University, Yoshida-Konoe cho, Sakyo ku, Kyoto, 606-8501 (Japan); Hiraoka, Yasushi [Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, Kobe, 651-2492 (Japan); Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, 565-0871 (Japan); Maki, Takahisa; Hayashi, Ikuko [Graduate School of Nanobioscience, Yokohama City University, Tsurumi, Yokohama, 230-0045 (Japan); Obuse, Chikashi [Graduate School of Life Science, Hokkaido University, Sapporo 001-0021 (Japan); Matsumoto, Tomohiro, E-mail: tmatsumo@house.rbc.kyoto-u.ac.jp [Graduate School of Biostudies, Kyoto University, Kitashirakawa-Oiwake cho, Sakyo ku, Kyoto, 606-8502 (Japan); Radiation Biology Center, Kyoto University, Yoshida-Konoe cho, Sakyo ku, Kyoto, 606-8501 (Japan)

    2012-02-01

    Mal3 is a fission yeast homolog of EB1, a plus-end tracking protein (+ TIP). We have generated a mutation (89R) replacing glutamine with arginine in the calponin homology (CH) domain of Mal3. Analysis of the 89R mutant in vitro has revealed that the mutation confers a higher affinity to microtubules and enhances the intrinsic activity to promote the microtubule-assembly. The mutant Mal3 is no longer a + TIP, but binds strongly the microtubule lattice. Live cell imaging has revealed that while the wild type Mal3 proteins dissociate from the tip of the growing microtubules before the onset of shrinkage, the mutant Mal3 proteins persist on microtubules and reduces a rate of shrinkage after a longer pausing period. Consequently, the mutant Mal3 proteins cause abnormal elongation of microtubules composing the spindle and aster. Mal3 is phosphorylated at a cluster of serine/threonine residues in the linker connecting the CH and EB1-like C-terminal motif domains. The phosphorylation occurs in a microtubule-dependent manner and reduces the affinity of Mal3 to microtubules. We propose that because the 89R mutation is resistant to the effect of phosphorylation, it can associate persistently with microtubules and confers a stronger stability of microtubules likely by reinforcing the cylindrical structure. -- Highlights: Black-Right-Pointing-Pointer We characterize a mutation (mal3-89R) in fission yeast homolog of EB1. Black-Right-Pointing-Pointer The mutation enhances the activity to assemble microtubules. Black-Right-Pointing-Pointer Mal3 is phosphorylated in a microtubule-dependent manner. Black-Right-Pointing-Pointer The phosphorylation negatively regulates the Mal3 activity.

  4. Chlamydophila psittaci genotype E/B transmission from African grey parrots to humans.

    Science.gov (United States)

    Harkinezhad, Taher; Verminnen, Kristel; Van Droogenbroeck, Caroline; Vanrompay, Daisy

    2007-08-01

    Thirty-six birds from a parrot relief and breeding centre, as well as the manager, were examined for the presence of Chlamydophila psittaci. In the relief unit, 5 of 20 African grey parrots showed depression, ruffled feathers, loss of weight and mild dyspnoea. The birds received no antibiotic treatment. Birds of the breeding unit, 14 blue and gold macaws and 2 green-winged macaws, were healthy. They received doxycycline at the start of each breeding season. The manager complained of shortness of breath but took no medication. Using a nested PCR enzyme immunoassay (EIA), Cp. psittaci was detected in the faeces of all five sick birds, as well as in a nasal and pharyngeal swab from the manager. The veterinarian and her assistant became infected while sampling the parrots, as pharyngeal and nasal swabs from both were positive by nested PCR/EIA after visiting the parrot relief and breeding centre, but they showed no clinical signs of infection. Bacteria could be isolated from three of five nested PCR/EIA-positive birds, the manager and the veterinarian, but not from the veterinary assistant. Using an ompA genotype-specific real-time PCR, Cp. psittaci genotype E/B was identified as the transmitted strain. All breeding birds tested negative for Cp. psittaci. This is believed to be the first report on Cp. psittaci genotype E/B transmission from parrots to humans. In contradiction to genotype A strains, which are thought to be highly virulent to both birds and men, the currently described genotype E/B strain apparently caused no severe clinical symptoms in either parrots or humans.

  5. The status of UV/EB curable product in North America: 1998-1999

    International Nuclear Information System (INIS)

    This author has previously reported survey results showing that the use of UV/EB materials has grown at a compound rate of about 10% per annum over the last decade. Together, with about 130 members of RadTech International North America, representing 90 organizations, we have updated and assessed the growth and activities of the industry. The panelists represent a cross section of end users, raw material and equipment suppliers, as well as formulators and consultants. Using a modified Delphi process with five separate survey rounds, a reasonable assessment was made of the advantages, disadvantages, growth rate and growth opportunities of this exciting technology

  6. Dual AO/EB Staining to Detect Apoptosis in Osteosarcoma Cells Compared with Flow Cytometry

    OpenAIRE

    Liu, Kuan; Liu, Peng-Cheng; Liu, Run; Wu, Xing

    2015-01-01

    Background The aim of this study was to evaluate the ability of dual acridine orange/ethidium bromide (AO/EB) staining to detect tumor cell apoptosis. According to apoptosis-associated changes of cell membranes during the process of apoptosis, a clear distinction is made between normal cells, early and late apoptotic cells, and necrotic cells. Material/Method We cultured human osteosarcoma cells with 30, 60, and 120 μg/ml kappa-selenocarrageenan. To assess the rates of cell proliferation and ...

  7. Creep properties of EB welded copper overpack at 125-175 deg C

    International Nuclear Information System (INIS)

    Electron Beam welds (EBW) chosen as primary sealing method by Posiva welding the over-pack canister lids of oxygen-free phosphorus micro-alloyed copper (OFP) have been tested for material properties relevant to long term creep life prediction. Creep rupture results are presented for the ruptured 175 deg C tests and for the ongoing long term tests at 150 deg C and 125 deg C. The current status (test time, creep strain and strain rate) of the ongoing tests are reported. The initial (175 deg C) results indicate that the EB welds are weaker than the parent material and that both round bar and spark eroded square test specimens produce weld strengths of about 0.75 at tests durations of 5000 h. The downward trend is however expected to continue for the longer test durations. The creep ductility shows decrease for the longer tests. Life estimates for the EB weld have been calculated at 100 deg C for both 50 and 80 MPa with the so far lowest measured EB weld strength factor (WSF=0.77). The state-of-the-art model on the available data give estimated lives of 21000 and 3000 years correspondingly. However, simulated to the expected temperature profile of the repository service the life fraction reached after 10000 years of service is 1 % and 7 % for the same stress levels. It is though important to remembered that the 80 MPa assumption is very conservative in nature and that the predictions do not take into account relaxation of stresses, further decline of the WSF or anisotropy of the weld and are therefore still to be considered indicative only. It is also to be remembered that there is only limited data in the long term regime for the weldments and that the estimates are based on the few EB data available in the public domain added with the Posiva data of this project. Improvement of the models and predictions are expected from the ongoing 125 deg C and 150 deg C long term tests. (orig.)

  8. Effects of Dimethyl Sulfoxide on Neuronal Response Characteristics in Deep Layers of Rat Barrel Cortex

    Science.gov (United States)

    Soltani, Narjes; Mohammadi, Elham; Allahtavakoli, Mohammad; Shamsizadeh, Ali; Roohbakhsh, Ali; Haghparast, Abbas

    2016-01-01

    Introduction: Dimethyl sulfoxide (DMSO) is a chemical often used as a solvent for water-insoluble drugs. In this study, we evaluated the effect of intracerebroventricular (ICV) administration of DMSO on neural response characteristics (in 1200–1500 μm depth) of the rat barrel cortex. Methods: DMSO solution was prepared in 10% v/v concentration and injected into the lateral ventricle of rats. Neuronal spontaneous activity and neuronal responses to deflection of the principal whisker (PW) and adjacent whisker (AW) were recorded in barrel cortex. A condition test ratio (CTR) was used to measure inhibitory receptive fields in barrel cortex. Results: The results showed that both PW and AW evoked ON and OFF responses, neuronal spontaneous activity and inhibitory receptive fields did not change following ICV administration of DMSO. Conclusion: Results of this study suggest that acute ICV administration of 10% DMSO did not modulate the electrophysiological characteristics of neurons in the l deep ayers of rat barrel cortex.

  9. Insertion of the CMS coil into the barrel yoke on 14 September 2005

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    Insertion of the CMS coil into the barrel yoke on 14 September 2005. The pictures have been taken in the CMS experimental hall SX5 in Cessy, neighbouring France. The second picture shows the insertion of the Inner Vacuum Tank.

  10. Data Acquisition and Management in the Calibration Processes of the CMS Barrel Muon Alignment System

    CERN Document Server

    Székely, Géza; Bencze, Gy L; Béni, N; Imrek, J; Molnár, J; Novák, D; Raics, P; Szabó, Z

    2007-01-01

    In order to be able to match correctly the track elements produced by a muon in the Tracker and the Muon System of the CMS experiment [1] the mutual alignment precision between the Tracker and the Barrel Muon System must be no worse than 100-400 micrometers depending on the radial distance of the muon chambers from the Tracker. To fulfill this requirement an alignment system had to be designed. This system contains subsystems for determining the positions of the barrel and endcap chambers while a third one connects these two to the Tracker. Since the Barrel muon chambers are embedded into the magnet yoke of the experiment a nonconventional alignment method had to be developed. In this paper we restrict ourselves to the Barrel Alignment System and the calibration methods of its components.

  11. Computer Aided Design and Stress Analysis of Nose Landing Gear Barrel (NLGB)

    OpenAIRE

    Sanjay Kumar Sardiwal; D. Harika Chowdary

    2015-01-01

    During the conceptual design phase of aircraft the integration of undercarriage system is very important and it is often difficult to achieve on the first time. The nose wheel landing gear preferred configurations for light naval trainer aircraft. The main objective of this project is to improve the static strength criteria and fatigue life of Nose Landing Gear Barrel considered. The investigations includes preliminary design layout for Nose Landing Gear Barrel and initial sizing ...

  12. CNOOC to Boost Oil Output to 290 Million Barrels in 2010

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ China National Offshore Oil Company Limited (CNOOC Limited)announced in early February that its targeted net production volume in 2010 is between 275 million and 290 million barrels ofoil equivalent(BOE).In its 2010 business strategy and development plan recently released to the public the offshore oil giant said the production goal was set given a West Texas Intermediate (WTI)oil price of US $75 per barrel in 2010.

  13. Ectopic anus with barrel gun perineum rare type of anorectal anomaly

    OpenAIRE

    Chamaria, Komal; Shetty, Roshan

    2013-01-01

    Perineal ectopic anus in female infants is not a very uncommon congenital anorectal anomaly with opening into the low vaginal or vulvar region. However, ectopic anus with barrel gun perineum is a less common variety. Patients generally present with frequent history of constipation, but may seek medical help for just aesthetic reasons. We present here one such case of an asymptomatic seven years old female with the rare form of anterior ectopic anus with barrel gun perineum without any fistulo...

  14. Modeling two-phase flow in barrels of weapons with combined charges

    OpenAIRE

    Nebojša P. Hristov; Slobodan R. Savić

    2011-01-01

    The processes occurring during the firing within barrels of weapons with combined charges are described aiming at the improvement of fire power of existing weapons and the design of new ones. The firing process simulation enables the optimization of gunpowders. The analysis of the obtained results helps in choosing the best combination of input-output parameters for the highest muzzle velocity possible while keeping powder gas maximum pressures inside the barrel at the lowest possible level.

  15. Modeling two-phase flow in barrels of weapons with combined charges

    Directory of Open Access Journals (Sweden)

    Nebojša P. Hristov

    2011-10-01

    Full Text Available The processes occurring during the firing within barrels of weapons with combined charges are described aiming at the improvement of fire power of existing weapons and the design of new ones. The firing process simulation enables the optimization of gunpowders. The analysis of the obtained results helps in choosing the best combination of input-output parameters for the highest muzzle velocity possible while keeping powder gas maximum pressures inside the barrel at the lowest possible level.

  16. The serotonin reuptake inhibitor citalopram suppresses activity in the neonatal rat barrel cortex in vivo.

    Science.gov (United States)

    Akhmetshina, Dinara; Zakharov, Andrei; Vinokurova, Daria; Nasretdinov, Azat; Valeeva, Guzel; Khazipov, Roustem

    2016-06-01

    Inhibition of serotonin uptake, which causes an increase in extracellular serotonin levels, disrupts the development of thalamocortical barrel maps in neonatal rodents. Previous in vitro studies have suggested that the disruptive effect of excessive serotonin on barrel map formation involves a depression at thalamocortical synapses. However, the effects of serotonin uptake inhibitors on the early thalamocortical activity patterns in the developing barrel cortex in vivo remain largely unknown. Here, using extracellular recordings of the local field potentials and multiple unit activity (MUA) we explored the effects of the selective serotonin reuptake inhibitor (SSRI) citalopram (10-20mg/kg, intraperitoneally) on sensory evoked activity in the barrel cortex of neonatal (postnatal days P2-5) rats in vivo. We show that administration of citalopram suppresses the amplitude and prolongs the delay of the sensory evoked potentials, reduces the power and frequency of the early gamma oscillations, and suppresses sensory evoked and spontaneous neuronal firing. In the adolescent P21-29 animals, citalopram affected neither sensory evoked nor spontaneous activity in barrel cortex. We suggest that suppression of the early thalamocortical activity patterns contributes to the disruption of the barrel map development caused by SSRIs and other conditions elevating extracellular serotonin levels. PMID:27016034

  17. Long-term potentiation in the neonatal rat barrel cortex in vivo.

    Science.gov (United States)

    An, Shuming; Yang, Jenq-Wei; Sun, Haiyan; Kilb, Werner; Luhmann, Heiko J

    2012-07-11

    Long-term potentiation (LTP) is important for the activity-dependent formation of early cortical circuits. In the neonatal rodent barrel cortex, LTP has been studied only in vitro. We combined voltage-sensitive dye imaging with extracellular multielectrode recordings to study whisker stimulation-induced LTP in the whisker-to-barrel cortex pathway of the neonatal rat barrel cortex in vivo. Single whisker stimulation at 2 Hz for 10 min induced an age-dependent expression of LTP in postnatal day (P) 0 to P14 rats, with the strongest expression of LTP at P3-P5. The magnitude of LTP was largest in the activated barrel-related column, smaller in the surrounding septal region, and no LTP could be observed in the neighboring barrel. Current source density analyses revealed an LTP-associated increase of synaptic current sinks in layer IV/lower layer II/III at P3-P5 and in the cortical plate/upper layer V at P0-P1. Our study demonstrates for the first time an age-dependent and spatially confined LTP in the barrel cortex of the newborn rat in vivo.

  18. The Influence of EB-Irradiated Treatment on Enhancing Barrier Property and Crystallization Behavior of Rubber-Toughened Nanocomposites

    Directory of Open Access Journals (Sweden)

    N. A. Jamal

    2011-01-01

    Full Text Available Electron beam (EB irradiation technique was introduced to modify the crystallization and oxygen (O2 barrier properties of high density-polyethylene (HDPE/ethylene propylene diene monomer (EPDM matrix and HDPE/EPDM filled withorganophilic montmorillonite (OMMT. The absorbed dose for EB-irradiation was fixed at 100 kGy. HDPE/EPDM matrix and HDPE/EPDM filled with OMMT at 4 vol% loading were prepared via melt intercalation method. It was found that the barrier resistance of HDPE/EPDM filled withOMMT against oxygen (O2 transmission was significantly enhanced by EB-irradiation absorbed dose of 100 kGy as compared to the control system. The crystallization temperature, Tc, and melting temperature, Tm, were also improved with the addition of OMMT along with the aids of EB-irradiation technique. Field emission scanning electron microscope (FESEM revealed that the stacking condition of OMMT particles was greatly reduced by EB-irradiation treatment as evidenced by finer surface and less formation of voids.

  19. A single-photon sensitive ebCMOS camera: The LUSIPHER prototype

    Energy Technology Data Exchange (ETDEWEB)

    Barbier, R., E-mail: rbarbier@ipnl.in2p3.fr [Universite de Lyon, Universite Lyon 1, Lyon F-69003 (France); CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, Villeurbanne F-69622 (France); Cajgfinger, T.; Calabria, P.; Chabanat, E.; Chaize, D.; Depasse, P.; Doan, Q.T.; Dominjon, A.; Guerin, C.; Houles, J.; Vagneron, L. [Universite de Lyon, Universite Lyon 1, Lyon F-69003 (France); CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, Villeurbanne F-69622 (France); Baudot, J.; Dorokhov, A.; Dulinski, W.; Winter, M. [Universite Louis Pasteur Strasbourg, Strasbourg (France); CNRS/IN2P3, Institut Pluridisciplinaire Hubert Curien, Strasbourg F-67037 (France); Kaiser, C.T. [PHOTONIS Netherlands BV, Roden B.O. Box 60, 9300 AB Roden (Netherlands)

    2011-08-21

    Processing high-definition images with single-photon sensitivity acquired above 500 frames per second (fps) will certainly find ground-breaking applications in scientific and industrial domains such as nano-photonics. However, current technologies for low light imaging suffer limitations above the standard 30 fps to keep providing both excellent spatial resolution and signal-over-noise. This paper presents the state of the art on a promising way to answer this challenge, the electron bombarded CMOS (ebCMOS) detector. A large-scale ultra fast single-photon tracker camera prototype produced with an industrial partner is described. The full characterization of the back-thinned CMOS sensor is presented and a method for Point Spread Function measurements is elaborated. Then the study of the ebCMOS performance is presented for two different multi-alkali cathodes, S20 and S25. Point Spread Function measurements carried out on an optical test bench are analysed to extract the PSF of the tube by deconvolution. The resolution of the tube is studied as a function of temperature, high voltage and incident wavelength. Results are discussed for both multi-alkali cathodes as well as a Maxwellian modelization of the radial initial energy of the photo-electrons.

  20. Proceedings of the FNCA 2004 workshop on application of electron accelerator. EB treatment of flue gases

    International Nuclear Information System (INIS)

    'Forum for Nuclear Cooperation in Asia (FNCA) Workshop on Application of Electron Accelerator' was sponsored by the Ministry of Education, Culture, Sports, Science and Technology (MEXT). The 2004 workshop was jointly organized by China Atomic Energy Authority (CAEA), Institute of Modern Physics/Chinese Academy of Sciences(IMP-CAS) and Japan Atomic Energy Research Institute (JAERI). It was held at Prime Hotel, Beijing, China from 6 to 10 September 2004. The Workshop was attended by 28 experts on application of electron accelerator from each of the participating countries, i.e., China, Indonesia, Korea, Malaysia, The Philippines, Thailand and Vietnam, and 10 participants from Japan. On the first day, a National Executive Management Seminar on Application of Electron Accelerator was held and attended by 67 participants. Total of 20 papers including Seminar lectures, invited papers on flue gas treatment by electron beam, and country reports on EB irradiation system were presented. The major areas of interest of FNCA member states for cooperation were identified for application of low energy electron accelerator as liquid (natural polymer, wastewater), solid (hydrogel, thin film) and gases (flue gas). Based on the proposal from the participating countries, discussions were carried out to re-formulate the work plan of the project for three years until FY 2005. It was agreed the FNCA 2005 workshop on EB treatment of wastewater will be held in Korea. All manuscripts submitted by every speaker were included in the proceedings. The 20 of the presented papers are indexed individually. (J.P.N.)

  1. Mechanical properties of EB-PVD ZrO{sub 2} thermal barrier coatings; Mechanische Eigenschaften von EB-PVD ZrO{sub 2} Waermedaemmschichten

    Energy Technology Data Exchange (ETDEWEB)

    Held, Carolin

    2014-08-29

    In this work, the elastic properties of thermal barrier coatings which were produced by electron-beam enhanced physical vapour deposition were investigated, as well as the dependency of the properties on the sample microstructure, the thermal treatment and the test method. For this purpose, not only commercial coatings were characterized, but also special sample material was used which consists of a 1 mm thick layer of EB-PVD TBC. This material was isothermally heat treated for different times at 950 C, 1100 C and 1200 C and then tested in a specially developed miniaturized bend test and by dynamic mechanical analysis. The sample material was tested by nanoindentation in order to measure the Young's modulus on a local scale, and the porosity of the samples was determined by microstructure analysis and porosimetry. The decrease of porosity could be connected with sintering and subsequent stiffening of the material. The test results are dependent on the tested volume. A small test volume leads to larger measured Young's moduli, while a large test volume yields lower values. The test volume also has an influence on the increase of stiffness during thermal exposure. With a small tested volume, a quicker increase of the Young's modulus was registered, which could be associated to the sintering of local structures.

  2. Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna.

    Directory of Open Access Journals (Sweden)

    Gernot Walko

    2011-12-01

    Full Text Available Autosomal recessive mutations in the cytolinker protein plectin account for the multisystem disorders epidermolysis bullosa simplex (EBS associated with muscular dystrophy (EBS-MD, pyloric atresia (EBS-PA, and congenital myasthenia (EBS-CMS. In contrast, a dominant missense mutation leads to the disease EBS-Ogna, manifesting exclusively as skin fragility. We have exploited this trait to study the molecular basis of hemidesmosome failure in EBS-Ogna and to reveal the contribution of plectin to hemidesmosome homeostasis. We generated EBS-Ogna knock-in mice mimicking the human phenotype and show that blistering reflects insufficient protein levels of the hemidesmosome-associated plectin isoform 1a. We found that plectin 1a, in contrast to plectin 1c, the major isoform expressed in epidermal keratinocytes, is proteolytically degraded, supporting the notion that degradation of hemidesmosome-anchored plectin is spatially controlled. Using recombinant proteins, we show that the mutation renders plectin's 190-nm-long coiled-coil rod domain more vulnerable to cleavage by calpains and other proteases activated in the epidermis but not in skeletal muscle. Accordingly, treatment of cultured EBS-Ogna keratinocytes as well as of EBS-Ogna mouse skin with calpain inhibitors resulted in increased plectin 1a protein expression levels. Moreover, we report that plectin's rod domain forms dimeric structures that can further associate laterally into remarkably stable (paracrystalline polymers. We propose focal self-association of plectin molecules as a novel mechanism contributing to hemidesmosome homeostasis and stabilization.

  3. Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway.

    Science.gov (United States)

    Wang, Yihua; Zhou, Xiaobo; Zhu, Hongxia; Liu, Shuang; Zhou, Cuiqi; Zhang, Guo; Xue, Liyan; Lu, Ning; Quan, Lanping; Bai, Jinfeng; Zhan, Qimin; Xu, Ningzhi

    2005-10-01

    Esophageal squamous cell carcinoma (ESCC) has a multifactorial etiology involving environmental and/or genetic factors. End-binding protein 1 (EB1), which was cloned as an interacting partner of the adenomatous polyposis coli (APC) tumor suppressor protein, was previously found overexpressed in ESCC. However, the precise role of EB1 in the development of this malignancy has not yet been elucidated. In this study, we analysed freshly resected ESCC specimens and demonstrated that EB1 was overexpressed in approximately 63% of tumor samples compared to matched normal tissue. We report that overexpression of EB1 in the ESCC line EC9706 significantly promotes cell growth, whereas suppression of EB1 protein level by RNA interference significantly inhibited growth of esophageal tumor cells. In addition, EB1 overexpression induced nuclear accumulation of beta-catenin and promoted the transcriptional activity of beta-catenin/T-cell factor (TCF). These effects were partially or completely abolished by coexpression of APC or DeltaN TCF4, respectively. Also, we found that EB1 affected the interaction between beta-catenin and APC. Furthermore, EB1 overexpression was correlated with cytoplasmic/nuclear accumulation of beta-catenin in primary human ESCC. Taken together, these results support the novel hypothesis that EB1 overexpression may play a role in the development of ESCC by affecting APC function and activating the beta-catenin/TCF pathway.

  4. Pathogensis-related proteins induced by endophytic bacteria EBS05 in tomato plant%内生细菌EBS05对番茄病程相关蛋白的诱导作用研究

    Institute of Scientific and Technical Information of China (English)

    李俊州; 赵玉华; 文才艺; 臧睿; 张俊

    2014-01-01

    以番茄江蔬14为材料,研究了内生细菌EBS05对番茄病程相关蛋白基因表达的诱导作用,同时,测定了番茄体内β-1,3-葡聚糖酶和几丁质酶活性变化.结果表明,内生细菌EBS05可诱导番茄体内PR1,PR2和PR3基因持续增量表达,并有效激活PR5基因表达,进而提高番茄对番茄黄化曲叶病毒(TYLCCV)的系统抗性;内生细菌EBS05诱导处理再接种TYLCCV后,番茄体内β-1,3-葡聚糖酶和几丁质酶活性均明显高于对照,并分别于接种后第7d和第9d达到活性峰值.结合TYLCCV侵染番茄的病程分析,β-1,3-葡聚糖酶和几丁质酶活性的升高与内生细菌EBS05诱导番茄对TYLCCV的系统抗性呈正相关.%Genes expression of pathogensis-related proteins (PRPs) induced by endophytic bacteria EBS05 in tomato plant were investigated using var.Jiangshu 14 as test material,and the activities of β-1,3-glueanas and chitinase were determined too.The results showed that strain EBS05 could induce the overexpression of PR1,PR2 and PR3 genes,and activate the gene PR5 to high level expression in tomato plant,thus increasing the systemic resistance to Tomato Yellow Leaf Curl China virus (TYL-CCV).The activities of β-1,3-glueanas and chitinase in tomato plants inoculated with TYLCCV after pretreated by strain EBS05 were higher than those in the control plants,and the activity peak appeared at the 9th and 7th days post inoculation,respectively.The increase of β-1,3-glueanas and chitinase activities were positively correlated with the systemic resistance to TYLCCV in tomato plants mediated by strain EBS05 based on the pathogensis of TYLCCV-infected tomato plants.

  5. The Functional Role of eL19 and eB12 Intersubunit Bridge in the Eukaryotic Ribosome.

    Science.gov (United States)

    Kisly, Ivan; Gulay, Suna P; Mäeorg, Uno; Dinman, Jonathan D; Remme, Jaanus; Tamm, Tiina

    2016-05-22

    During translation, the two eukaryotic ribosomal subunits remain associated through 17 intersubunit bridges, five of which are eukaryote specific. These are mainly localized to the peripheral regions and are believed to stabilize the structure of the ribosome. The functional importance of these bridges remains largely unknown. Here, the essentiality of the eukaryote-specific bridge eB12 has been investigated. The main component of this bridge is ribosomal protein eL19 that is composed of an N-terminal globular domain, a middle region, and a long C-terminal α-helix. The analysis of deletion mutants demonstrated that the globular domain and middle region of eL19 are essential for cell viability, most likely functioning in ribosome assembly. The eB12 bridge, formed by contacts between the C-terminal α-helix of eL19 and 18S rRNA in concert with additional stabilizing interactions involving either eS7 or uS17, is dispensable for viability. Nevertheless, eL19 mutants impaired in eB12 bridge formation displayed slow growth phenotypes, altered sensitivity/resistance to translational inhibitors, and enhanced hyperosmotic stress tolerance. Biochemical analyses determined that the eB12 bridge contributes to the stability of ribosome subunit interactions in vitro. 60S subunits containing eL19 variants defective in eB12 bridge formation failed to form 80S ribosomes regardless of Mg(2+) concentration. The reassociation of 40S and mutant 60S subunits was markedly improved in the presence of deacetylated tRNA, emphasizing the importance of tRNAs during the subunit association. We propose that the eB12 bridge plays an important role in subunit joining and in optimizing ribosome functionality. PMID:27038511

  6. Crack prediction in EB-PVD thermal barrier coatings based on the simulation of residual stresses

    Science.gov (United States)

    Chen, J. W.; Zhao, Y.; Liu, S.; Zhang, Z. Z.; Ma, J.

    2016-07-01

    Thermal barrier coatings systems (TBCs) are widely used in the field of aerospace. The durability and insulating ability of TBCs are highly dependent on the residual stresses of top coatings, thus the investigation of the residual stresses is helpful to understand the failure mechanisms of TBCs. The simulation of residual stresses evolution in electron beam physical vapor deposition (EB-PVD) TBCs is described in this work. The interface morphology of TBCs subjected to cyclic heating and cooling is observed using scanning electron microscope (SEM). An interface model of TBCs is established based on thermal elastic-plastic finite method. Residual stress distributions in TBCs are obtained to reflect the influence of interfacial roughness. Both experimental and simulation results show that it is feasible to predict the crack location by stress analysis, which is crucial to failure prediction.

  7. Uplatnění marketingu v sektoru služeb

    OpenAIRE

    Pluháček, Stanislav

    2012-01-01

    Tato diplomová práce se zabývá marketingem hotelových služeb pro Hotel Celnice, který se nachází ve městě Břeclav, v srdci Lednicko-valtického areálu. Pojednává o marketingovém mixu hotelu a snaží se najít nedostatky v této oblasti a navrhnout zlepšení, které by vedlo k lepším komunikačním i ekonomickým výsledkům. This thesis deals with marketing of hotel services for the Hotel Celnice, located in the town of Breclav in the heart of the Lednice-Valtice area. It discusses the marketing mix ...

  8. Globální marketing internetových služeb

    OpenAIRE

    Číp, Vojtěch

    2011-01-01

    Cílem této práce je provést analýzu globálních marketingových strategií korporací zabývajících se poskytovaním služeb na internetu. Tyto společnosti poté konfrontovat s českými podniky působícím v obdobných oblastech a odhadnout budoucí vývoj. Nakonec pak nalézt takový podnikatelský model, který by uspěl, ne je na českém trhu, ale i v globální konkurenci. Abstract (annotation): Subject of this thesis is to analyze the marketing strategy of corporations working in the internet environment. ...

  9. Failure mechanism of EB-PVD thermal barrier coatings on NiAl substrate

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Yttria stabilized zirconia(YSZ) was deposited on the line cut β-NiAl substrate by electron-beam physical vapour deposition(EB-PVD), and the cyclic oxidation behaviors of thermal barrier coatings on β-NiAl substrate were investigated in 1 h thermal cycles at 1 200 ℃ in air. The results show that the samples fail after 80-100 cycles. Sub-interface cavitations in the substrate develop due to depletion of Al in forming thermally grown oxides(TGOs). The collapse and closing up of cavities result in the ragged YSZ/TGO/substrate interface. Since the specific crack trajectories are quite sensitive to local geometry, cracks along the YSZ/TGO/substrate interfaces ultimately lead to YSZ spallation.

  10. Oxidation and Hot Corrosion of Gradient Thermal Barrier Coatings Prepared by EB-PVD

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The performances of gradient thermal barrier coatings (GTBCs) produced by EB-PVD were evaluated by isothermaloxidation and cyclic hot corrosion (HTHC) tests. Compared with conventional two-layered TBCs, the GTBCs exhibitebetter resistance to not only oxidation but also hot-corrosion. A dense Al2O3 layer in the GTBCs effectively prohibitesinward diffusion of O and S and outward diffusion of Al and Cr during the tests. On the other hand, an "inlaid"interface, resulting from oxidation of the Al along the columnar grains of the bond coat, enhances the adherence ofAl2O3 layer. Failure of the GTBC finally occurred by cracking at the interface between the bond coat and Al2O3layer, due to the combined effect of sulfidation of the bond coat and thermal cycling.

  11. Thermo-Mechanical Analysis of Water-Cooled Gun Barrel During Burst Firing

    Institute of Scientific and Technical Information of China (English)

    FAN Li-xia; HU Zhi-gang; ZHAO Jian-bo

    2006-01-01

    The thermo-mechanical stress and deformation of water-cooled gun barrel during burst firing are studied by finite element analysis (FEA). The problem is modeled in two steps: 1) A transient heat transfer analysis is first carried out in order to determine temperature evolution and to predict the residual temperatures during the burst firing event; 2) The thermo-mecha-nical stresses and deformation caused by both the residual temperature field and the gas pressure are then calculated. The results show that the residual temperature field tends to a steady state with the increasing of rounds. The residual temperature field has much effect on the gun barrel stress and deformation, especially on the assembly area between barrel and water jacket. The gage between the barrel and water jacket is the critical factor to the thermo-mechanical stress and deformation. The results of this analysis will be very useful to develop the new strength design theory of the liquid-cooled gun barrel.

  12. Unusual mode of firearm injury from the recoiled rear end of a gun barrel.

    Science.gov (United States)

    Agrawal, A; Malla, G; Joshi, S; Kumar, A; Koirala, S

    2008-09-01

    Atypical gunshot wounds are caused by a diverse set of parameters relating to weapons and ammunition. We report a previously-unreported and atypical mode of gunshot wound produced by a detached rear end of the barrel of a gun following accidental gun fire, and discuss the difficulties in the management. A 36-year-old man presented to the emergency department with an alleged history of injury on the forehead with the rear end of a gun barrel following accidental gunfire while cleaning the nozzle. Since the time of injury, the patient was in an altered sensorium and had weakness on the right side of the body. There was minimal but continuous bleeding from the wound, with extrusion of brain matter. Skull radiograph showed that the rear end of the barrel had entered the left frontal bone, with associated depressed fracture of the frontal bone. The patient underwent a bicoronal, bifrontal craniotomy with a T-shaped extension towards the barrel to facilitate the reflection of the scalp flap and to avoid any movement of the barrel as it might further injure the brain. Necrotic brain, dura and bone pieces were removed. The patient was doing well at follow-up except for mild residual motor deficits. This case illustrates that while working with limited facilities, particularly in underdeveloped countries, a careful clinical assessment, interpretation of available images and a judicious operative approach can help to save the patient. PMID:18830529

  13. Triggering and measuring bent cosmic muon tracks with the Muon Spectrometer barrel for the first time

    CERN Multimedia

    Fabio Cerutti

    During the ATLAS barrel toroid stability test, bent cosmic muon tracks were seen for the first time in the ATLAS cavern by means of the ATLAS muon spectrometer. The barrel toroid has been powered at its nominal current (20.5 thousand Amperes) and kept in steady state for more than one day during the weekend of 18-19 November (see a report on this test in the Magnet section). During this test one large sector and part of a small sector of the barrel muon spectrometer were readout and used to detect the cosmic muons tracks bent by the toroidal magnetic field. Thirteen muon stations in the feet sectors (sectors 13 and 14) have been used in this test. The muon stations are formed of Resistive Plate Chambers (RPC) that were providing the muon trigger, and Monitored Drift Tubes that were used to measure with high accuracy the muon curvature hence their momentum. The Level-1 Barrel trigger chain was based on the Barrel Middle Large chambers equipped with final production modules on both the on-detector and the o...

  14. Evaluation of Factors Affecting Polyhydroxyalkanoates Production by Comamonas sp. EB172 Using Central Composite Design

    Directory of Open Access Journals (Sweden)

    Noor Azman Mohd Johar

    2012-09-01

    Full Text Available Aims: Statistical approach, central composite design (CCD was used to investigate the complex interaction among temperature (25-37 °C, initial medium pH (5-9, inoculum size (4-10 % (v/v, concentration of (NH42SO4 (0-1 g/L and concentration of mixed organic acids (5-10 g/L in the production of polyhydroxyalkanoates by Comamonas sp. EB172.Methodology and Results: Mixed organic acids derived from anaerobically treated palm oil mill effluent (POME containing acetic:propionic:butyric (ratio of 3:1:1 were used as carbon source in the batch culture of Comamonas sp. EB172 to produce polyhydoxyalkanoates (PHAs. The analysis of variance (ANOVA showed that all five factors were significantly important in the batch fermentation by shake flask with a P value of less than 0.001. The optimal temperature, initial medium pH, inoculum size, concentration of (NH42SO4 and concentration of mixed organic acids were 30 °C, 7.04, 4.0 % (v/v, 0.01 g/L and 5.05 g/L respectively.Conclusion, significance and impact of study: Optimization of the production medium containing mixed organic acids has improved the PHA production for more than 2 folds. Under optimal condition in the shake flask fermentation, the predicted growth is 2.98 g/L of dry cell weight (DCW with 47.07 wt % of PHA content. The highest yield of PHA was 0.28 g of PHA per g mixed organic acids.

  15. Proceedings of the FNCA 2005 workshop on application of electron accelerator. EB treatment of wastewater

    International Nuclear Information System (INIS)

    'Forum for Nuclear Cooperation in Asia (FNCA) Workshop on Application of Electron Accelerator' was sponsored by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. The 2005 workshop was jointly organized by the Ministry of Science and Technology (MOST), Korea, Korea Atomic Energy Research Institute and Japan Atomic Energy Agency (JAEA). It was held at the International Nuclear Technology and Education Center (INTEC/KAERI), Daejeon, Korea from 14 to 18 November 2005. The Workshop was attended by 32 experts on application of electron accelerator from each of the participating countries, i.e., China (1), Indonesia (1), Korea (18), Malaysia (2), Philippines (1), Thailand (1) and Vietnam (1), and 7 participants from Japan. On the first day, a National Executive Management Seminar on Application of Electron Accelerator was held and attended by 45 participants. Total of 20 papers including Seminar lectures, invited papers on wastewater treatment by electron beam, and country reports on EB irradiation system were presented. The major areas of interest of FNCA member states for cooperation were identified for application of low energy electron accelerator to liquids (natural polymer, wastewater), solids (hydrogel, thin film) and gases (flue gas). Based on the evaluation and proposal from the participating countries, discussions were carried out to re-formulate the work plan of the project on natural polymers and wastewater for three years until FY 2008. It was agreed the FNCA 2006 workshop on EB crosslinking of natural polymers would be held in Malaysia. All manuscripts submitted by every speaker were included in the proceedings. The 18 presented papers are indexed individually. (J.P.N.)

  16. Residual stresses and structure of EB-PVD thermal barrier coatings exposed at high temperature

    International Nuclear Information System (INIS)

    The substrate material was nickel based superalloy (In738LC), CoNiCrAlY was pressureless plasma-sprayed on the substrate as the bond coating. As the top coating, zirconia with 4 mol% yittria was made by a electron beam-physical vapor deposition (EB-PVD) with a rotation. The thickness of the bond coating was about 0.18 mm, and the thickness of the top coating was about 0.12 mm. The rotation speeds of specimens in the EB-PVD process were 5 rpm, 10 rpm and 20 rpm. The specimens were exposed at 1273 K for 200 h. The in-plane residual stress was measured by a conventional X-ray method, and the out-of-plane residual strain was measured by a strain scanning method with hard synchrotron X-rays. For the specimens with 5 rpm and 10 rpm, the in-plane compressive residual stresses were released by the high temperature exposure. For the specimen with 20 rpm, the in-plane residual stress did not change by the high temperature exposure, because it was very small before the exposure. The in-plane residual stresses were large compression near the interface. For the specimens with 5 rpm and 10 rpm, the out-of plane stresses were small from the coating surface but became a compression near the interface. Both in-plane and out-of-plane residual stresses of the specimen with 20 rpm were very small. In the effect of decreasing the residual stress, the rotation speed of 20 rpm was the excellent condition. According to the observation with a scanning electron microscope, the feather-like columnar structure decreased the high temperature exposure. This volume decrease caused the release of the in-plane residual stresses. (author)

  17. Removal of metal ions from wastewater using EB irradiation in combination with HA/TiO₂/UV treatment.

    Science.gov (United States)

    Zaki, A A; El-Gendy, Naima A

    2014-04-30

    The electron beam (EB) irradiation technology was applied for removal of Cu(2+), Sr(2+), and Co(2+) ions from wastewater. The aim of this study is to achieve an efficient treatment process of wastewater using EB and introducing a combination of humic acid (HA) as a natural organic polymer and ultraviolet irradiation of a TiO2 (TiO2/UV), as a suspended catalyst in the treatment of wastewater solutions (TiO2/UV+HA). The experimental results showed that the percentage removal of Cu(2+), Sr(2+), and Co(2+)ions was 41%, 87% and 75% respectively, at 125 kGy. In the presence of TiO2 photocatalyst and exposure of the investigated wastewater to ultraviolet rays before irradiation by the EB the percentage removal of Cu(2+) ions became 51%, while the percentage removal of both Sr(2+) and Co(2+) ions was slightly improved; was 87% and 75%, respectively at the same EB dose. On the other hand, by introducing the combination of TiO2/UV+HA, only an irradiation dose of about 50kGy led to removal of Cu(2+), Sr(2+), and Co(2+) completely from the wastewater. Mechanisms of interactions between HA and Cu(2+), Co(2+) and Sr(2+) metal ions were suggested and discussed.

  18. Potential for radionuclide immobilization in the EBS/NFE: solubility limiting phases for neptunium, plutonium, and uranium

    Energy Technology Data Exchange (ETDEWEB)

    Rard, J. A., LLNL

    1997-10-01

    Retardation and dispersion in the far field of radionuclides released from the engineered barrier system/near field environment (EBS/NFE) may not be sufficient to prevent regulatory limits being exceeded at the accessible environment. Hence, a greater emphasis must be placed on retardation and/or immobilization of radionuclides in the EBS/NFE. The present document represents a survey of radionuclide-bearing solid phases that could potentially form in the EBS/NFE and immobilize radionuclides released from the waste package and significantly reduce the source term. A detailed literature search was undertaken for experimental solubilities of the oxides, hydroxides, and various salts of neptunium, plutonium, and uranium in aqueous solutions as functions of pH, temperature, and the concentrations of added electrolytes. Numerous solubility studies and reviews were identified and copies of most of the articles were acquired. However, this project was only two months in duration, and copies of some the identified solubility studies could not be obtained at short notice. The results of this survey are intended to be used to assess whether a more detailed study of identified low- solubility phase(s) is warranted, and not as a data base suitable for predicting radionuclide solubility. The results of this survey may also prove useful in a preliminary evaluation of the efficacy of incorporating chemical additives to the EBS/NFE that will enhance radionuclide immobilization.

  19. Design and fabrication of an advanced, lightweight, high stiffness, railgun barrel concept

    International Nuclear Information System (INIS)

    An advanced lightweight and high stiffness railgun barrel design and incorporates several new design features and advanced materials is being developed by SPARTA, Inc. The program is sponsored by the U.S. Army Armament Research, Development, and Engineering Center ARDEC and by the Defense Advanced Research Projects Agency (DARPA). The railgun is 7 m long and has a 90 mm round bore. It is designed to accommodate both solid and plasma armatures. Muzzle energies are expected in the range of 9 to 15 MJ. Analysis and final design has been completed and the barrel and other railgun subassemblies are in the fabrication stage at SPARTA, Inc. in San Diego, California. Initial testing will be conducted at Maxwell Laboratories Green Farm facility in September 1990 and will subsequently be shipped to the ARDEC Railgun Laboratory in October 1990 for full power operation and testing. This paper discusses the design features and fabrication approaches for this high performance, lightweight railgun barrel system

  20. CHANGES IN VOLATILE COMPOSITION AND SENSORY PROPERTIES OF VUGAVA WINES AGED IN CROATIA OAK BARRELS

    Directory of Open Access Journals (Sweden)

    Stanka HERJAVEC

    2001-09-01

    Full Text Available Vugava musts were fermented in medium-toasted Croatian barrique barrels (225 L made from Quercus petrea and Q. robur oak wood. The oak species used in this research infl uenced the specifi c change of the aroma structure of Vugava wines. During the age period the increase in the concentration of cis and trans oaklactons, guaiacol, eugenol, furfural and 5-methylfurfural was noted. Wines fermented and aged in Q. petrea barrels have higher concentrations of most volatile phenols compared to wines from Q. robur oak wood. From the organoleptic point of view this study suggested that fermentation and on the lees ageing production method in Croatian oak barrels positively infl uenced the quality of Vugava wines where best results were achieved by use of Q. petrea oak wood.

  1. Persistence of biological traces in gun barrels--an approach to an experimental model.

    Science.gov (United States)

    Courts, Cornelius; Madea, Burkhard; Schyma, Christian

    2012-05-01

    Traces of backspatter in gun barrels after homicidal or suicidal contact shots may be a valuable source of forensic evidence. Yet, a systematic investigation of the persistence and durability of DNA from biological traces in gun barrels is lacking. Our aim was to generate a realistic model to emulate blood and tissue spatters in gun barrels generated by contact gunshots at biological targets and to analyse the persistence and typability of DNA recovered from such stains. Herein, we devise and evaluate three different models for the emulation of backspatter from contact shots: a gelatine-based model with embedded blood bags, a model based on a spongious matrix soaked with blood and covered with a thin plastic membrane and a head model consisting of an acrylic half sphere filled with ballistic gelatine and with blood bags attached to the sphere under a 3-mm silicone layer. The sampling procedure for all three models: a first shot was fired with several types of guns at each model construction and subsequently a second shot was fired at a backstop. Blood samples were collected after each shot by probing the inner surface of the front and rear end of the respective gun barrel with a sterile swab. DNA was then extracted and quantified and up to 20 different short tandem repeat (STR) systems were amplified to generate DNA profiles. Although DNA quantity and STR typing results were heterogenous between the models, all models succeeded in delivering full STR profiles even after more than one shot. We conclude that biological traces in gun barrels are robust and accessible to forensic analysis and that systematic examination of the inside of gun barrels may be advisable for forensic casework.

  2. Performance analysis for the CALIFA Barrel calorimeter of the R3B experiment

    Science.gov (United States)

    Alvarez-Pol, H.; Ashwood, N.; Aumann, T.; Bertini, D.; Cabanelas, P.; Casarejos, E.; Cederkall, J.; Cortina-Gil, D.; Díaz Fernández, P.; Duran, I.; Fiori, E.; Galaviz, D.; Labiche, M.; Nacher, E.; Pietras, B.; Savran, D.; Tengblad, O.; Teubig, P.

    2014-12-01

    The CALIFA calorimeter is an advanced detector for gamma rays and light charged particles, accordingly optimized for the demanding requirements of the physics programme proposed for the R3B facility at FAIR. The multipurpose character of CALIFA is required to fulfil challenging demands in energy resolution (5-6% at 1 MeV for gamma rays) and efficiency. Charged particles, e.g. protons of energies up to 320 MeV in the Barrel section, should also be identified with an energy resolution better to 1%. CALIFA is divided into two well-separated sections: a "Forward EndCap" and a cylindrical "Barrel" covering an angular range from 43.2° to 140.3°. The Barrel section, based on long CsI(Tl) pyramidal frustum crystals coupled to large area avalanche photodiodes (LAAPDs), attains the requested high efficiency for calorimetric purposes. The construction of the CALIFA Demonstrator, comprising 20% of the total detector, has already been initiated, and commissioning experiments are expected for 2014. The assessment of the capabilities and expected performance of the detector elements is a crucial step in their design, along with the prototypes evaluation. For this purpose, the Barrel geometry has been carefully implemented in the simulation package R3BRoot, including easily variable thicknesses of crystal wrapping and carbon fibre supports. A complete characterization of the calorimeter response (including efficiency, resolution, evaluation of energy and reconstruction losses) under different working conditions, with several physics cases selected to probe the detector performance over a wide range of applications, has been undertaken. Prototypes of different sections of the CALIFA Barrel have been modeled and their responses have been evaluated and compared with the experimental results. The present paper summarizes the outcome of the simulation campaign for the entire Barrel section and for the corresponding prototypes tested at different European installations.

  3. Recruitment of EB1, a master regulator of microtubule dynamics, to the surface of the Theileria annulata schizont.

    Directory of Open Access Journals (Sweden)

    Kerry L Woods

    2013-05-01

    Full Text Available The apicomplexan parasite Theileria annulata transforms infected host cells, inducing uncontrolled proliferation and clonal expansion of the parasitized cell population. Shortly after sporozoite entry into the target cell, the surrounding host cell membrane is dissolved and an array of host cell microtubules (MTs surrounds the parasite, which develops into the transforming schizont. The latter does not egress to invade and transform other cells. Instead, it remains tethered to host cell MTs and, during mitosis and cytokinesis, engages the cell's astral and central spindle MTs to secure its distribution between the two daughter cells. The molecular mechanism by which the schizont recruits and stabilizes host cell MTs is not known. MT minus ends are mostly anchored in the MT organizing center, while the plus ends explore the cellular space, switching constantly between phases of growth and shrinkage (called dynamic instability. Assuming the plus ends of growing MTs provide the first point of contact with the parasite, we focused on the complex protein machinery associated with these structures. We now report how the schizont recruits end-binding protein 1 (EB1, a central component of the MT plus end protein interaction network and key regulator of host cell MT dynamics. Using a range of in vitro experiments, we demonstrate that T. annulata p104, a polymorphic antigen expressed on the schizont surface, functions as a genuine EB1-binding protein and can recruit EB1 in the absence of any other parasite proteins. Binding strictly depends on a consensus SxIP motif located in a highly disordered C-terminal region of p104. We further show that parasite interaction with host cell EB1 is cell cycle regulated. This is the first description of a pathogen-encoded protein to interact with EB1 via a bona-fide SxIP motif. Our findings provide important new insight into the mode of interaction between Theileria and the host cell cytoskeleton.

  4. Recruitment of EB1, a Master Regulator of Microtubule Dynamics, to the Surface of the Theileria annulata Schizont

    KAUST Repository

    Woods, Kerry L.

    2013-05-09

    The apicomplexan parasite Theileria annulata transforms infected host cells, inducing uncontrolled proliferation and clonal expansion of the parasitized cell population. Shortly after sporozoite entry into the target cell, the surrounding host cell membrane is dissolved and an array of host cell microtubules (MTs) surrounds the parasite, which develops into the transforming schizont. The latter does not egress to invade and transform other cells. Instead, it remains tethered to host cell MTs and, during mitosis and cytokinesis, engages the cell\\'s astral and central spindle MTs to secure its distribution between the two daughter cells. The molecular mechanism by which the schizont recruits and stabilizes host cell MTs is not known. MT minus ends are mostly anchored in the MT organizing center, while the plus ends explore the cellular space, switching constantly between phases of growth and shrinkage (called dynamic instability). Assuming the plus ends of growing MTs provide the first point of contact with the parasite, we focused on the complex protein machinery associated with these structures. We now report how the schizont recruits end-binding protein 1 (EB1), a central component of the MT plus end protein interaction network and key regulator of host cell MT dynamics. Using a range of in vitro experiments, we demonstrate that T. annulata p104, a polymorphic antigen expressed on the schizont surface, functions as a genuine EB1-binding protein and can recruit EB1 in the absence of any other parasite proteins. Binding strictly depends on a consensus SxIP motif located in a highly disordered C-terminal region of p104. We further show that parasite interaction with host cell EB1 is cell cycle regulated. This is the first description of a pathogen-encoded protein to interact with EB1 via a bona-fide SxIP motif. Our findings provide important new insight into the mode of interaction between Theileria and the host cell cytoskeleton. 2013 Woods et al.

  5. ATLAS Level-1 Muon Barrel Trigger robustness study at X5 test facility

    CERN Document Server

    Di Mattia, A; Nisati, A; Pastore, F C; Vari, R; Veneziano, Stefano; Aielli, G; Camarri, P; Cardarelli, R; Di Ciaccio, A; Di Simone, A; Liberti, B; Santonico, R

    2004-01-01

    The present paper describes the Level-1 Barrel Muon Trigger performance as expected with the current configuration of the RPC detectors, as designed for the Barrel Muon Spectrometer of ATLAS. Results of a beam test performed at the X5-GIF facility at CERN are presented in order to show the trigger efficiency with different conditions of RPC detection efficiency and several background rates. Small RPC chambers with part of the final trigger electronics are used, while the trigger coincidence logic is applied off-line using a detailed simulation model. copy 2003 Published by Esevier B.V. 3 Refs.

  6. Evaluation of using short barrel DHS in treatment of intertrochanteric fractures

    OpenAIRE

    Tahmasbi M; Sajjadi Saravi M; Alami Harandi B

    2001-01-01

    Cut out or extrusion of the lag screw from the superior aspect of head and neck of the femur is one of the most common and devastating complications of the surgery of the intertrochanteric fractures with DHS. The exact cause of this complications is unknown, but it seems to be related to osteopenia, inappropriate position of lag screw inside head of the femur and inability of DHS to slide inside the barrel, which is the most ignored risk factor. We used short barrel Dynamic Hip Screw (DHS) fo...

  7. Observations of a solar storm from the stratosphere: The BARREL Mission

    Science.gov (United States)

    Halford, Alexa

    2016-07-01

    During the Balloon Array for Radiation belt Relativistic Electron Losses (BARREL) second campaign, BARREL observed with a single primary instrument, a 3"x3" NaI spectrometer measuring 20 keV - 10 MeV X-rays [Woodger et al 2015 JGR], portions of an entire solar storm. This very small event, in terms of geomagnetic activity, or one of the largest of the current solar cycle, in terms of solar energetic particle events, has given us a very clear set of observations of the response of the day side magnetosphere to the arrival of an interplanetary coronal mass ejection shock. The BARREL mission of opportunity working in tandem with the Van Allen Probes was designed to study the loss of radiation belt electrons to the ionosphere and upper atmosphere. However BARREL is able to see X-rays from a multitude of sources. During the second campaign, the Sun produced, and BARREL observed, an X-class flare [McGregor et al in prep.]. This was followed by BARREL observations of X-rays, gamma-rays, and directly injected protons from the solar energetic particle (SEP) event associated with the eruption from the Sun while simultaneously the Van Allen Probes observed the SEP protons in the inner magnetosphere [Halford et al 2016 submitted JGR]. Two days later the shock generated by the interplanetary coronal mass ejection (ICME-shock) hit the Earth while BARREL was in conjunction with the Van Allen Probes and GOES [Halford et al 2015 JGR]. Although this was a Mars directed CME and the Earth only received a glancing blow [Möstl et al 2015 Nat. Commun., Mays et al 2015 ApJ], the modest compression led to the formation of ultra low frequency (ULF) waves, electromagnetic ion cyclotron (EMIC) waves, and very low frequency (VLF) whistler mode waves [Halford and Mann 2016 submitted to JGR]. The combination of these waves and the enhancement of the local particle population led to precipitation of electrons remotely observed by BARREL. This was not a Halloween, Bastille Day, or one of the now

  8. 27 CFR 25.160 - Tax adjustment for brewers who produce more than 2,000,000 barrels of beer.

    Science.gov (United States)

    2010-04-01

    ... who produce more than 2,000,000 barrels of beer. 25.160 Section 25.160 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Determination of Tax § 25.160 Tax adjustment for brewers who produce more than 2,000,000 barrels of beer....

  9. Computer Aided Design and Stress Analysis of Nose Landing Gear Barrel (NLGB

    Directory of Open Access Journals (Sweden)

    Sanjay Kumar Sardiwal

    2015-04-01

    Full Text Available During the conceptual design phase of aircraft the integration of undercarriage system is very important and it is often difficult to achieve on the first time. The nose wheel landing gear preferred configurations for light naval trainer aircraft. The main objective of this project is to improve the static strength criteria and fatigue life of Nose Landing Gear Barrel considered. The investigations includes preliminary design layout for Nose Landing Gear Barrel and initial sizing has been done. It has been designed and evaluated for strength criteria. A method of analysis for the design of Nose Landing Gear Barrel made up of Al-Cu alloy (BS L 168 T6511 with static loads of axial, bending and normal loads are applied. The geometric modeling of the Nose Landing Gear Barrel was carried out using CAD package CATIA V5 R19 and pre and post processing was done through MSC/PATRAN. The stresses and displacements are obtained with the application of MSC/NASTRAN finite element software.

  10. Superior long-term stability of a glucose biosensor based on inserted barrel plating gold electrodes.

    Science.gov (United States)

    Hsu, Cheng-Teng; Hsiao, Hung-Chan; Fang, Mei-Yen; Zen, Jyh-Myng

    2009-10-15

    Disposable one shot usage blood glucose strips are routinely used in the diagnosis and management of diabetes mellitus and their performance can vary greatly. In this paper we critically evaluated the long-term stability of glucose strips made of barrel plating gold electrodes. Compared to other glucose biosensing platforms of vapor deposited palladium and screen printed carbon electrodes, the proposed glucose biosensor was found to show the best stability among the three biosensing platforms in thermal acceleration experiments at 40 degrees C for 6 months with an average bias of 3.4% at glucose concentrations of 5-20 mM. The precision test of this barrel plating gold glucose biosensor also showed the best performance (coefficients of variation in the range of 1.4-2.4%) in thermal acceleration experiments at 40 degrees C, 50 degrees C and 70 degrees C for 27 days. Error grid analysis revealed that all measurements fell in zone A and zone B. Regression analysis showed no significant difference between the proposed biosensor and the reference method at 99% confidence level. The amperometric glucose biosensor fabricated by inserting two barrel plating gold electrodes onto an injection-molding plastic base followed by immobilizing with a bio-reagent layer and membrane was very impressive with a long-term stability up to 2.5 years at 25 degrees C. Overall, these results indicated that the glucose oxidase/barrel plating gold biosensing platform is ideal for long-term accurate glycemic control.

  11. Supramolecular chains of high nuclearity {Mn(III)25} barrel-like single molecule magnets.

    Science.gov (United States)

    Giannopoulos, Dimosthenis P; Thuijs, Annaliese; Wernsdorfer, Wolfgang; Pilkington, Melanie; Christou, George; Stamatatos, Theocharis C

    2014-01-25

    The first application of 1-methyl-1H-pyrrole-2-carbaldehyde oxime as a ligand for the coordination of paramagnetic transition metal ions has afforded a new {Mn(III)25} barrel-like cluster linked via Na(+) cations into a 1D polymeric topology that exhibits single-molecule magnetic behaviour.

  12. The beta-barrel outer membrane protein assembly complex of Neisseria meningitidis.

    NARCIS (Netherlands)

    Volokhina, E.B.; Beckers, F.; Tommassen, J.; Bos, M.P.

    2009-01-01

    The evolutionarily conserved protein Omp85 is required for outer membrane protein (OMP) assembly in gram-negative bacteria and in mitochondria. Its Escherichia coli homolog, designated BamA, functions with four accessory lipoproteins, BamB, BamC, BamD, and BamE, together forming the beta-barrel asse

  13. Effect of Associative Learning on Memory Spine Formation in Mouse Barrel Cortex.

    Science.gov (United States)

    Jasinska, Malgorzata; Siucinska, Ewa; Jasek, Ewa; Litwin, Jan A; Pyza, Elzbieta; Kossut, Malgorzata

    2016-01-01

    Associative fear learning, in which stimulation of whiskers is paired with mild electric shock to the tail, modifies the barrel cortex, the functional representation of sensory receptors involved in the conditioning, by inducing formation of new inhibitory synapses on single-synapse spines of the cognate barrel hollows and thus producing double-synapse spines. In the barrel cortex of conditioned, pseudoconditioned, and untreated mice, we analyzed the number and morphological features of dendritic spines at various maturation and stability levels: sER-free spines, spines containing smooth endoplasmic reticulum (sER), and spines containing spine apparatus. Using stereological analysis of serial sections examined by transmission electron microscopy, we found that the density of double-synapse spines containing spine apparatus was significantly increased in the conditioned mice. Learning also induced enhancement of the postsynaptic density area of inhibitory synapses as well as increase in the number of polyribosomes in such spines. In single-synapse spines, the effects of conditioning were less pronounced and included increase in the number of polyribosomes in sER-free spines. The results suggest that fear learning differentially affects single- and double-synapse spines in the barrel cortex: it promotes maturation and stabilization of double-synapse spines, which might possibly contribute to permanent memory formation, and upregulates protein synthesis in single-synapse spines. PMID:26819780

  14. Construction of the ATLAS semi-conductor tracker (SCT) barrel modules in Japan

    CERN Document Server

    Kato, Y; Ikegami, Y; Iwata, Y; Kobayashi, K; Kohriki, T; Kondo, T; Kurita, M; Minagawa, M; Miyamoto, T; Morinaka, S; Nakano, I; Ohsugi, T; Sengoku, H; Shimma, S

    2003-01-01

    We have developed a semi-automated assembly system and constructed 124 silicon microstrip modules so far for the ATLAS SCT barrel. This article describes the assembly procedure, evaluations of precisions and the module survey results. A precision of similar to 2mum is achievable with this assembly system.

  15. Computed tomography manifestation of a triple-barreled aortic dissection: the Mercedes-Benz mark sign.

    Science.gov (United States)

    Shin, M S; Zorn, G L; Ho, K J

    1988-04-01

    Computed tomographic (CT) findings of a rare case of triple-barreled aortic dissection was described. CT demonstrated the extent of dissection, a communication between two channels, and three lumens separated by the intimal flap and a thin undetached tunica media, resembling a Mercedes-Benz mark. PMID:3168525

  16. PHYSICAL VAPOR DEPOSITION OF TANTALUM ON GUN BARREL STEEL (SYSTEMS ANLAYSIS BRANCH, SUSTAINABLE TECHNOLOGY DIVISION, NRMRL)

    Science.gov (United States)

    This project entails the development of an alternative technology for plating gun barrel steel to replace the process electroplating of chrome (Cr-electroplate) with physical vapor deposition of tantalum (Ta-PVD). Developed by Benet Laboratory at Watervliet Arsenal, this project'...

  17. Twenty years of barrel-stave flextensional transducer technology in Canada

    Science.gov (United States)

    Jones, Dennis F.

    2005-04-01

    The barrel-stave flextensional transducer, a compact underwater sound source, was conceived at DRDC Atlantic in 1986 [G. W. McMahon and D. F. Jones, U.S. Patent No. 4,922,470 (1 May 1990); Canadian Patent No. 1,285,646 (2 July 1991)]. Over the years, five barrel-stave designs belonging to three flextensional classes were built and tested at DRDC Atlantic. Three Class I transducers with operating frequencies ranging from 800 to 1600 Hz were integrated into submarine communications buoys, low frequency active horizontal projector arrays, and a broadband sonar towbody. A high-power Class II and broadband (1-7 kHz) Class III transducer were deployed under the ice in the Lincoln Sea for research related to rapidly deployable surveillance systems. These barrel-stave flextensional transducers have also supported a variety of marine mammal studies including vocal mimicry in long-finned pilot whales, coda dialects in sperm whales, and the R&D of acoustic detection and tracking systems for endangered northern right whales. In August 2004 a barrel-stave transducer was used to lure a trapped juvenile humpback whale to the sluice gates of a tidal generating station on the Annapolis River in Nova Scotia by transmitting humpback whale calls underwater. The acoustic performance parameters for all 5 transducers will be presented.

  18. Late emergence of the vibrissa direction selectivity map in the rat barrel cortex.

    Science.gov (United States)

    Kremer, Yves; Léger, Jean-François; Goodman, Dan; Brette, Romain; Bourdieu, Laurent

    2011-07-20

    In the neocortex, neuronal selectivities for multiple sensorimotor modalities are often distributed in topographical maps thought to emerge during a restricted period in early postnatal development. Rodent barrel cortex contains a somatotopic map for vibrissa identity, but the existence of maps representing other tactile features has not been clearly demonstrated. We addressed the issue of the existence in the rat cortex of an intrabarrel map for vibrissa movement direction using in vivo two-photon imaging. We discovered that the emergence of a direction map in rat barrel cortex occurs long after all known critical periods in the somatosensory system. This map is remarkably specific, taking a pinwheel-like form centered near the barrel center and aligned to the barrel cortex somatotopy. We suggest that this map may arise from intracortical mechanisms and demonstrate by simulation that the combination of spike-timing-dependent plasticity at synapses between layer 4 and layer 2/3 and realistic pad stimulation is sufficient to produce such a map. Its late emergence long after other classical maps suggests that experience-dependent map formation and refinement continue throughout adult life.

  19. Construction and test of the final CMS Barrel Drift Tube Muon Chamber prototype

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar-Benitez, M.; Alberdi, J.; Arneodo, M.; Banicz, K.; Benettoni, M.; Benvenuti, A.; Bethke, S.; Cerrada, M. E-mail: cerrada@ciemat.es; Cirio, R.; Colino, N.; Conti, E.; Dallavalle, M.; Daniel, M.; Dattola, D.; Daudo, F.; De Giorgi, M.; Dosselli, U.; Fanfani, A.; Fanin, C.; Fouz, M.C.; Gasparini, F.; Gasparini, U.; Giacomelli, P.; Giordano, V.; Gonella, F.; Grandi, C.; Guaita, P.; Guerzoni, M.; Lacaprara, S.; Lippi, I.; Marcellini, S.; Marin, J.; Martinelli, R.; Maselli, S.; Meneguzzo, A.; Migliore, E.; Mocholi, J.; Monaco, V.; Montanari, A.; Montanari, C.; Odorici, F.; Oller, J.C.; Paoletti, S.; Passaseo, M.; Pegoraro, M.; Peroni, C.; Puerta, J.; Reithler, H.; Romero, A.; Romero, L.; Ronchese, P.; Rossi, A.M.; Rovelli, T.; Sacchi, R.; Salicio, J.M.; Staiano, A.; Steinbeck, T.; Torassa, E.; Travaglini, R.; Ventura, L.; Ventura, S.; Vitelli, A.; Voetee, F.; Wegner, M.; Willmott, C.; Zotto, P.; Zumerle, G

    2002-03-21

    A prototype of the CMS Barrel Muon Detector incorporating all the features of the final chambers was built using the mass production assembly procedures and tools. The performance of this prototype was studied in a muon test beam at CERN and the results obtained are presented in this paper.

  20. Construction and test of the final CMS barrel drift tube muon chamber prototype

    CERN Document Server

    Aguilar-Benítez, M; Arneodo, M; Banicz, K; Benettoni, M; Benvenuti, Alberto C; Bethke, Siegfried; Cerrada, M; Cirio, R; Colino, N; Conti, E; Dallavalle, G M; Daniel, M; Dattola, D; Daudo, F; De Giorgi, M; Dosselli, U; Fanfani, A; Fanin, C; Fouz-Iglesias, M C; Gasparini, F; Gasparini, U; Glacomelli, P; Giordano, V; Gonella, F; Grandi, C; Guaita, P; Guerzoni, M; Lacaprara, S; Lippi, I; Marcellini, S; Marin, J; Martinelli, R; Maselli, S; Meneguzzo, Anna Teresa; Migliore, E; Mocholí-Mocholí, J; Monaco, V; Montanari, A; Montnari, C; Odorici, F; Oller, J C; Paoletti, S; Passaseo, M; Pegoraro, M; Peroni, C; Puerta, J; Reithler, H; Romero, A; Romero, L; Ronchese, P; Rossi, A M; Rovelli, T; Sacchi, R; Salicio, J M; Staiano, A; Steinbeck, T M; Torassa, E; Travaglini, R; Ventura, L; Ventura, Sandro; Vitelli, A; Voetee, F; Wegner, M; Willmott, C; Zotto, P L; Zumerle, G

    2002-01-01

    A prototype of the CMS Barrel Muon Detector incorporating all the features of the final chambers was built using the mass production assembly procedures and tools. The performance of this prototype was studied in a muon test beam at CERN and the results obtained are presented in this paper. (12 refs).

  1. A summary of the BARREL campaigns: Technique for studying electron precipitation

    Science.gov (United States)

    Woodger, L. A.; Halford, A. J.; Millan, R. M.; McCarthy, M. P.; Smith, D. M.; Bowers, G. S.; Sample, J. G.; Anderson, B. R.; Liang, X.

    2015-06-01

    The Balloon Array for Radiation belt Relativistic Electron Losses (BARREL) studies the loss of energetic electrons from Earth's radiation belts. BARREL's array of slowly drifting balloon payloads was designed to capitalize on magnetic conjunctions with NASA's Van Allen Probes. Two campaigns were conducted from Antarctica in 2013 and 2014. During the first campaign in January and February of 2013, there were three moderate geomagnetic storms with SYM-Hmin < -40 nT. Similarly, two minor geomagnetic storms occurred during the second campaign, starting in December of 2013 and continuing on into February of 2014. Throughout the two campaigns, BARREL observed electron precipitation over a wide range of energies and exhibiting temporal structure from hundreds of milliseconds to hours. Relativistic electron precipitation was observed in the dusk to midnight sector, and microburst precipitation was primarily observed near dawn. In this paper we review the two BARREL science campaigns and discuss the data products and analysis techniques as applied to relativistic electron precipitation observed on 19 January 2013.

  2. Learning-Dependent Plasticity of the Barrel Cortex Is Impaired by Restricting GABA-Ergic Transmission

    Science.gov (United States)

    Posluszny, Anna; Liguz-Lecznar, Monika; Turzynska, Danuta; Zakrzewska, Renata; Bielecki, Maksymilian; Kossut, Malgorzata

    2015-01-01

    Experience-induced plastic changes in the cerebral cortex are accompanied by alterations in excitatory and inhibitory transmission. Increased excitatory drive, necessary for plasticity, precedes the occurrence of plastic change, while decreased inhibitory signaling often facilitates plasticity. However, an increase of inhibitory interactions was noted in some instances of experience-dependent changes. We previously reported an increase in the number of inhibitory markers in the barrel cortex of mice after fear conditioning engaging vibrissae, observed concurrently with enlargement of the cortical representational area of the row of vibrissae receiving conditioned stimulus (CS). We also observed that an increase of GABA level accompanied the conditioning. Here, to find whether unaltered GABAergic signaling is necessary for learning-dependent rewiring in the murine barrel cortex, we locally decreased GABA production in the barrel cortex or reduced transmission through GABAA receptors (GABAARs) at the time of the conditioning. Injections of 3-mercaptopropionic acid (3-MPA), an inhibitor of glutamic acid decarboxylase (GAD), into the barrel cortex prevented learning-induced enlargement of the conditioned vibrissae representation. A similar effect was observed after injection of gabazine, an antagonist of GABAARs. At the behavioral level, consistent conditioned response (cessation of head movements in response to CS) was impaired. These results show that appropriate functioning of the GABAergic system is required for both manifestation of functional cortical representation plasticity and for the development of a conditioned response. PMID:26641862

  3. Evaluation of mRNA Localization Using Double Barrel Scanning Ion Conductance Microscopy.

    Science.gov (United States)

    Nashimoto, Yuji; Takahashi, Yasufumi; Zhou, Yuanshu; Ito, Hidenori; Ida, Hiroki; Ino, Kosuke; Matsue, Tomokazu; Shiku, Hitoshi

    2016-07-26

    Information regarding spatial mRNA localization in single cells is necessary for a better understanding of cellular functions in tissues. Here, we report a method for evaluating localization of mRNA in single cells using double-barrel scanning ion conductance microscopy (SICM). Two barrels in a nanopipette were filled with aqueous and organic electrolyte solutions and used for SICM and as an electrochemical syringe, respectively. We confirmed that the organic phase barrel could be used to collect cytosol from living cells, which is a minute but sufficient amount to assess cellular status using qPCR analysis. The water phase barrel could be used for SICM to image topography with subcellular resolution, which could be used to determine positions for analyzing mRNA expression. This system was able to evaluate mRNA localization in single cells. After puncturing the cellular membrane in a minimally invasive manner, using SICM imaging as a guide, we collected a small amount cytosol from different positions within a single cell and showed that mRNA expression depends on cellular position. In this study, we show that SICM imaging can be utilized for the analysis of mRNA localization in single cells. In addition, we fully automated the pipet movement in the XYZ-directions during the puncturing processes, making it applicable as a high-throughput system for collecting cytosol and analyzing mRNA localization. PMID:27399804

  4. Electrostatic design of the barrel CRID (Cherenkov Ring Imaging Detector) and associated measurements

    Energy Technology Data Exchange (ETDEWEB)

    Abe, K.; Hasegawa, K.; Suekane, F.; Yuta, H. (Tohoku Univ., Sendai (Japan). Dept. of Physics); Antilogus, P.; Aston, D.; Bienz, T.; Bird, F.; Dunwoodie, W.; Hallewell, G.; Kawahara, H.; Kwon, Y.; Leith, D.W.G.S.; Muller, D.; Nagamine, T.; Pavel, T.; Ratcliff, B.; Rensing, P.; Schultz, D.; Shapiro, S.; Simopoulos, C.; Solodov, E.; Toge, N.; Va' Vra, J. Williams, H. (Stanford Linear Accelerator Center, Menlo Park, CA (US

    1990-04-01

    We report on the electrostatic design and related measurements of the barrel Cherenkov Ring Imaging Detector for the Stanford Large Detector experiment at the Stanford Linear Accelerator Center Linear Collider. We include test results of photon feedback in TMAE-laden gas, distortion measurements in the drift boxes and corona measurements. 13 refs., 21 figs.

  5. Effect of Associative Learning on Memory Spine Formation in Mouse Barrel Cortex

    Directory of Open Access Journals (Sweden)

    Malgorzata Jasinska

    2016-01-01

    Full Text Available Associative fear learning, in which stimulation of whiskers is paired with mild electric shock to the tail, modifies the barrel cortex, the functional representation of sensory receptors involved in the conditioning, by inducing formation of new inhibitory synapses on single-synapse spines of the cognate barrel hollows and thus producing double-synapse spines. In the barrel cortex of conditioned, pseudoconditioned, and untreated mice, we analyzed the number and morphological features of dendritic spines at various maturation and stability levels: sER-free spines, spines containing smooth endoplasmic reticulum (sER, and spines containing spine apparatus. Using stereological analysis of serial sections examined by transmission electron microscopy, we found that the density of double-synapse spines containing spine apparatus was significantly increased in the conditioned mice. Learning also induced enhancement of the postsynaptic density area of inhibitory synapses as well as increase in the number of polyribosomes in such spines. In single-synapse spines, the effects of conditioning were less pronounced and included increase in the number of polyribosomes in sER-free spines. The results suggest that fear learning differentially affects single- and double-synapse spines in the barrel cortex: it promotes maturation and stabilization of double-synapse spines, which might possibly contribute to permanent memory formation, and upregulates protein synthesis in single-synapse spines.

  6. Construction and Performance of the ATLAS SCT Barrels and Cosmic Tests

    CERN Document Server

    Demirkoz, Bilge Melahat

    2007-01-01

    ATLAS is a multi-purpose detector for the LHC and will detect proton-proton collisions with center of mass energy of $14$TeV. Part of the central inner detector, the Semi-Conductor Tracker (SCT) barrels, were assembled and tested at Oxford University and later integrated at CERN with the TRT (Transition Radiation Tracker) barrel. The barrel SCT is composed of 4 layers of silicon strip modules with two sensor layers with $80 \\mu$m channel width. The design of the modules and the barrels has been optimized for low radiation length while maintaining mechanical stability, bringing services to the detector, and ensuring a cold and dry environment. The high granularity, high detector efficiency and low noise occupancy ($ < 5 \\times 10^{-4}$) of the SCT will enable ATLAS to have an efficient pattern recognition capability. Due to the binary nature of the SCT read-out, a stable read-out system and the calibration system is of critical importance. SctRodDaq is the online software framework for the calibration and a...

  7. Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells.

    Directory of Open Access Journals (Sweden)

    Satoko Nakamura

    Full Text Available Recently, the EB1 and XMAP215/TOG families of microtubule binding proteins have been demonstrated to bind autonomously to the growing plus ends of microtubules and regulate their behaviour in in vitro systems. However, their functional redundancy or difference in cells remains obscure. Here, we compared the nanoscale distributions of EB1 and ch-TOG along microtubules using high-resolution microscopy techniques, and also their roles in microtubule organisation in interphase HeLa cells. The ch-TOG accumulation sites protruded ∼100 nm from the EB1 comets. Overexpression experiments showed that ch-TOG and EB1 did not interfere with each other's localisation, confirming that they recognise distinct regions at the ends of microtubules. While both EB1 and ch-TOG showed similar effects on microtubule plus end dynamics and additively increased microtubule dynamicity, only EB1 exhibited microtubule-cell cortex attachment activity. These observations indicate that EB1 and ch-TOG regulate microtubule organisation differently via distinct regions in the plus ends of microtubules.

  8. Current Status and Performance Tests of Korea Heat Load Test Facility KoHLT-EB

    International Nuclear Information System (INIS)

    A commissioning test has been scheduled to establish the installation and preliminary performance experiments of the copper hypervapotron mockups. And a qualification test will be performed to evaluate the CuCrZr duct liner in the ITER neutral beam injection facility and the ITER first wall small-scale mockups of the semi-prototype, at up to 1.5 and 5 MW/m2 high heat flux. Also, this system will be used to test other PFCs for ITER and materials for tokamak reactors. Korean high heat flux test facility(KoHLT-EB; Korea Heat Load Test facility - Electron Beam) by using an electron beam system has been constructed in KAERI to perform the qualification test for ITER blanket FW semi-prototype mockups, hypervapotron cooling devices in fusion devices, and other ITER plasma facing components. The commissioning and performance tests with the supplier of e-gun system have been performed on November 2012. The high heat flux test for hypervapotron cooling device and calorimetry were performed to measure the surface heat flux, the temperature profile and cooling performance. Korean high heat flux test facility for the plasma facing components of nuclear fusion machines will be constructed to evaluate the performance of each component. This facility for the plasma facing materials will be equipped with an electron beam system with a 60 kV acceleration gun

  9. Effect of Bond Coat Materials on Thermal Fatigue Failure of EB-PVD Thermal Barrier Coatings

    Science.gov (United States)

    Yamagishi, Satoshi; Okazaki, Masakazu; Sakaguchi, Motoki; Matsubara, Hideaki

    Effect of MCrAlY bond coat alloy systems on thermal fatigue failure of thermal barrier coatings (TBCs) was investigated, where the TBC specimen consisted of Ni-based superalloy IN738LC substrate, bond coat, and 8 wt.% Y2O3-stabilized ZrO2 (YSZ) top coat. The top coat was fabricated by EB-PVD method with 250 μm in thickness. Three kinds of MCrAlY alloys were studied as the bond coat material. Employing the originally developed test equipment, thermal fatigue tests were carried out, by applying thermal cycles between 400 and 950°C in air. Special attention was paid not only to the failure life of the TBC specimen, but also the underlying failure mechanisms. The experimental results clearly demonstrated that the effect of MCrAlY bond coat alloys on the thermal fatigue life was very significant. Some discussions were made on the experimental results based on the measurements of mechanical and metallurgical properties of the bond coat alloys: i.e., elastic stiffness, thermal expansion coefficient and high temperature oxidation resistance.

  10. Current Status and Performance Tests of Korea Heat Load Test Facility KoHLT-EB

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sukkwon; Jin, Hyunggon; Shin, Kyuin; Choi, Boguen; Lee, Eohwak; Yoon, Jaesung; Lee, Dongwon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Duckhoi; Cho, Seungyon [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2013-05-15

    A commissioning test has been scheduled to establish the installation and preliminary performance experiments of the copper hypervapotron mockups. And a qualification test will be performed to evaluate the CuCrZr duct liner in the ITER neutral beam injection facility and the ITER first wall small-scale mockups of the semi-prototype, at up to 1.5 and 5 MW/m{sup 2} high heat flux. Also, this system will be used to test other PFCs for ITER and materials for tokamak reactors. Korean high heat flux test facility(KoHLT-EB; Korea Heat Load Test facility - Electron Beam) by using an electron beam system has been constructed in KAERI to perform the qualification test for ITER blanket FW semi-prototype mockups, hypervapotron cooling devices in fusion devices, and other ITER plasma facing components. The commissioning and performance tests with the supplier of e-gun system have been performed on November 2012. The high heat flux test for hypervapotron cooling device and calorimetry were performed to measure the surface heat flux, the temperature profile and cooling performance. Korean high heat flux test facility for the plasma facing components of nuclear fusion machines will be constructed to evaluate the performance of each component. This facility for the plasma facing materials will be equipped with an electron beam system with a 60 kV acceleration gun.

  11. An ebCMOS camera system for marine bioluminescence observation: The LuSEApher prototype

    Energy Technology Data Exchange (ETDEWEB)

    Dominjon, A., E-mail: a.dominjon@ipnl.in2p3.fr [CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, Villeurbanne F-69622 (France); Ageron, M. [CNRS/IN2P3, Centre de Physique des Particules de Marseille, Marseille, F-13288 (France); Barbier, R. [CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, Villeurbanne F-69622 (France); Universite de Lyon, Universite Lyon 1, Lyon F-69003 (France); Billault, M.; Brunner, J. [CNRS/IN2P3, Centre de Physique des Particules de Marseille, Marseille, F-13288 (France); Cajgfinger, T. [CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, Villeurbanne F-69622 (France); Universite de Lyon, Universite Lyon 1, Lyon F-69003 (France); Calabria, P. [CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, Villeurbanne F-69622 (France); Chabanat, E. [CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, Villeurbanne F-69622 (France); Universite de Lyon, Universite Lyon 1, Lyon F-69003 (France); Chaize, D.; Doan, Q.T.; Guerin, C.; Houles, J.; Vagneron, L. [CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, Villeurbanne F-69622 (France)

    2012-12-11

    The ebCMOS camera, called LuSEApher, is a marine bioluminescence recorder device adapted to extreme low light level. This prototype is based on the skeleton of the LUSIPHER camera system originally developed for fluorescence imaging. It has been installed at 2500 m depth off the Mediterranean shore on the site of the ANTARES neutrino telescope. The LuSEApher camera is mounted on the Instrumented Interface Module connected to the ANTARES network for environmental science purposes (European Seas Observatory Network). The LuSEApher is a self-triggered photo detection system with photon counting ability. The presentation of the device is given and its performances such as the single photon reconstruction, noise performances and trigger strategy are presented. The first recorded movies of bioluminescence are analyzed. To our knowledge, those types of events have never been obtained with such a sensitivity and such a frame rate. We believe that this camera concept could open a new window on bioluminescence studies in the deep sea.

  12. Kinetic Monte Carlo Simulation of EB-PVD Film: Effects of Substrate Temperature

    Institute of Scientific and Technical Information of China (English)

    SHAN Ying-chun; HE Xiao-dong; LI Ming-wei; LI Yao; XU Jiu-jun

    2006-01-01

    The 2D kinetic Monte Carlo (KMC) simulation was used to study the effects of different substrate temperatures on the microstructure of Ni-Cr films in the process of deposition by the electron beam physical vapor deposition (EB-PVD). In the KMC model, substrate was assumed to be a "surface" of tight-packed rows, and the simulation includes two phenomena: adatom-surface collision and adatom diffusion. While the interaction between atoms was described by the embedded atom method, the jumping energy was calculated by the molecular static (MS) calculation. The initial location of the adatom was defined by the Momentum Scheme. The results reveal that there exists a critical substrate temperature which means that the lowest packing density and the highest surface roughness structure will be achieved when the temperature is lower than the smaller critical value, while the roughness of both surfaces and the void contents keep decreasing with the substrate temperature increasing until it reaches the higher critical value. The results also indicate that the critical substrate temperature rises as the deposition rate increases.

  13. Tumor Suppressor RARRES1 Regulates DLG2, PP2A, VCP, EB1, and Ankrd26

    Directory of Open Access Journals (Sweden)

    Ziad J. Sahab, Michael D. Hall, Lihua Zhang, Amrita K. Cheema, Stephen W. Byers

    2010-01-01

    Full Text Available Retinoic Acid Receptor Responder (RARRES1 initially identified as a novel retinoic acid receptor regulated gene in the skin is a putative tumor suppressor of unknown function. RARRES1 was knocked down in immortalized human prostatic epithelial cell line PWR-1E cells and differential protein expression was identified using differential in-gel electrophoresis (DIGE followed by matrix-assisted laser desorption ionization (MALDI mass spectrometry and western Blot analysis excluding highly abundant proteins routinely identified in almost all proteomics projects. Knock-down of RARRES1: 1- down-regulates PP2A, an enzyme involved in the negative regulation of the growth hormone-stimulated signal transduction pathways; 2- down-regulates Valosin-containing protein causing impaired autophagy; 3- up-regulates the tumor suppressor disks large 2; 4- up-regulates Ankrd26 that belongs to the POTE family of genes that are highly expressed in cancer patients with poor outcome; and 5- down-regulates EB1, a protein that is involved in spindle dynamics and chromosome alignment during mitosis.

  14. An ebCMOS camera system for marine bioluminescence observation: The LuSEApher prototype

    International Nuclear Information System (INIS)

    The ebCMOS camera, called LuSEApher, is a marine bioluminescence recorder device adapted to extreme low light level. This prototype is based on the skeleton of the LUSIPHER camera system originally developed for fluorescence imaging. It has been installed at 2500 m depth off the Mediterranean shore on the site of the ANTARES neutrino telescope. The LuSEApher camera is mounted on the Instrumented Interface Module connected to the ANTARES network for environmental science purposes (European Seas Observatory Network). The LuSEApher is a self-triggered photo detection system with photon counting ability. The presentation of the device is given and its performances such as the single photon reconstruction, noise performances and trigger strategy are presented. The first recorded movies of bioluminescence are analyzed. To our knowledge, those types of events have never been obtained with such a sensitivity and such a frame rate. We believe that this camera concept could open a new window on bioluminescence studies in the deep sea.

  15. Biohydrogen production by Clostridium butyricum EB6 from palm oil mill effluent

    Energy Technology Data Exchange (ETDEWEB)

    Chong, Mei-Ling; Rahim, Raha Abdul; Hassan, Mohd Ali [Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor (Malaysia); Shirai, Yoshihito [Graduate School of Life Sciences and System Engineering, Kyushu Institute of Technology, 808-0196 Hibikimo 2-4, Wakamatsu-ku, Kitakyushu-shi, Fukuoka (Japan)

    2009-01-15

    A hydrogen producer was successfully isolated from anaerobic digested palm oil mill effluent (POME) sludge. The strain, designated as Clostridium butyricum EB6, efficiently produced hydrogen concurrently with cell growth. A controlled study was done on a synthetic medium at an initial pH value of 6.0 with 10 g/L glucose with the maximum hydrogen production at 948 mL H{sub 2}/L-medium and the volumetric hydrogen production rate at 172 mL H{sub 2}/L-medium/h. The supplementation of yeast extract was shown to have a significant effect with a maximum hydrogen production of 992 mL H{sub 2}/L-medium at 4 g/L of yeast extract added. The effect of pH on hydrogen production from POME was investigated. Experimental results showed that the optimum hydrogen production ability occurred at pH 5.5. The maximum hydrogen production and maximum volumetric hydrogen production rate were at 3195 mL H{sub 2}/L-medium and 1034 mL H{sub 2}/L-medium/h, respectively. The hydrogen content in the biogas produced was in the range of 60-70%. (author)

  16. Performance analysis for the CALIFA Barrel calorimeter of the R{sup 3}B experiment

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez-Pol, H., E-mail: hector.alvarez@usc.es [Dpt. de Física de Partículas, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela (Spain); Ashwood, N. [School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom); Aumann, T. [Institut für Kernphysik, Technische Universität Darmstadt, D-64289 Darmstadt (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Bertini, D. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Cabanelas, P. [Dpt. de Física de Partículas, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela (Spain); Casarejos, E. [Universidade de Vigo, E-36310 Vigo (Spain); Cederkall, J. [Department of Physics, Lund University, SE 221 00 Lund (Sweden); Cortina-Gil, D.; Díaz Fernández, P.; Duran, I. [Dpt. de Física de Partículas, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela (Spain); Fiori, E. [ExtreMe Matter Institute EMMI and Research Division, GSI Helmholtzzentrum für Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Frankfurt Institute for Advanced Studies, D-60438 Frankfurt am Main (Germany); Galaviz, D. [Centro de Fsica Nuclear da Universidade de Lisboa, 1649-003 Lisbon (Portugal); Labiche, M. [STFC Daresbury Laboratory, Warrington WA4 4AD (United Kingdom); Nacher, E. [Instituto de Estructura de la Materia CSIC, Madrid (Spain); Pietras, B. [Dpt. de Física de Partículas, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela (Spain); and others

    2014-12-11

    The CALIFA calorimeter is an advanced detector for gamma rays and light charged particles, accordingly optimized for the demanding requirements of the physics programme proposed for the R{sup 3}B facility at FAIR. The multipurpose character of CALIFA is required to fulfil challenging demands in energy resolution (5–6% at 1 MeV for gamma rays) and efficiency. Charged particles, e.g. protons of energies up to 320 MeV in the Barrel section, should also be identified with an energy resolution better to 1%. CALIFA is divided into two well-separated sections: a “Forward EndCap” and a cylindrical “Barrel” covering an angular range from 43.2° to 140.3°. The Barrel section, based on long CsI(Tl) pyramidal frustum crystals coupled to large area avalanche photodiodes (LAAPDs), attains the requested high efficiency for calorimetric purposes. The construction of the CALIFA Demonstrator, comprising 20% of the total detector, has already been initiated, and commissioning experiments are expected for 2014. The assessment of the capabilities and expected performance of the detector elements is a crucial step in their design, along with the prototypes evaluation. For this purpose, the Barrel geometry has been carefully implemented in the simulation package R3BRoot, including easily variable thicknesses of crystal wrapping and carbon fibre supports. A complete characterization of the calorimeter response (including efficiency, resolution, evaluation of energy and reconstruction losses) under different working conditions, with several physics cases selected to probe the detector performance over a wide range of applications, has been undertaken. Prototypes of different sections of the CALIFA Barrel have been modeled and their responses have been evaluated and compared with the experimental results. The present paper summarizes the outcome of the simulation campaign for the entire Barrel section and for the corresponding prototypes tested at different European installations.

  17. Reconstruction of large limb bone defects with a double-barrel free vascularized fibular graft

    Institute of Scientific and Technical Information of China (English)

    BI Zheng-gang; HAN Xing-guang; FU Chun-jiang; CAO Yang; YANG Cheng-lin

    2008-01-01

    Background The use of a free,vascularized fibular graft is an important technique for the reconstruction of large defects in long bones.The technique has many advantages in strong,tubular bones; a more reliable vascular anatomy with a large vascular diameter and long pedicle is used,minimizing donor-site morbidity.Due to limitations in both fibular anatomy and mechanics,they cannot effectively be used to treat large limb bone defects due to their volume and strength.Methods From 1990 to 2001,16 clinical cases of large bone defects were treated using vascularized double-barrel fibular grafts.Patients were evaluated for an average of 10 months after surgery.Results All the patients achieved bony union; the average bone union took 10 months post surgery,and no stress fractures occurred.Compared with single fibular grafts,the vascularized double-barrel fibular grafts greatly facilitate bony union and are associated with fewer complications,suggesting that the vascularized double-barrel fibular graft is a valuable procedure for the correction of large bone defects in large,long bones in addition to enhancing bone intensity.Conclusions The vascularized double-barrel fibular graft is superior to the single fibular graft in stimulating osteogenous activity and biological mechanics for the correction of very large bone defects in large,long bones.Free vascularized folded double-barrel fibular grafts can not only fill up large bone defects,but also improve the intensity margin.Therefore,this study also widens its application and enlarges the treatment targets.However,in the case of bone deformability,special attention should be paid to bone fixation and protection of donor and recipient sites.

  18. Targeting FMS-related tyrosine kinase receptor 3 with the human immunoglobulin G1 monoclonal antibody IMC-EB10.

    Science.gov (United States)

    Youssoufian, Hagop; Rowinsky, Eric K; Tonra, James; Li, Yiwen

    2010-02-15

    FMS-related tyrosine kinase receptor 3 (FLT3) is a class III receptor tyrosine kinase that holds considerable promise as a therapeutic target in hematologic malignancies. Current efforts directed toward the development of small-molecule tyrosine kinase inhibitors of FLT3 may be limited by off-target toxicities and the development of drug resistance. Target-specific antibodies could overcome these hurdles and provide additional mechanisms to enhance the antitumor efficacy of FLT3 inhibitors. IMC-EB10 is a novel antibody directed against FLT3. The binding of IMC-EB10 to FLT3 results in antiproliferative effects in vitro and in mouse models engrafted with human leukemia cells that harbor wild-type or constitutively activated FLT3. Future clinical trials will test these notions formally and will identify the most appropriate opportunities for this member of a new generation of antileukemic therapies.

  19. Residual stress measurement of EB-welded plates with contour method. Part 2: FEM analysis of contour profiles

    Energy Technology Data Exchange (ETDEWEB)

    Romppanen, A.-J.; Immonen, E. [Process Flow Oy, Turku (Finland)

    2013-12-15

    The residual stresses formed as a result of Electronic Beam welding (EB-welding) in copper are investigated by Posiva. In the present study, residual stresses of EB-welded copper plates were studied with contour method. In the method eleven copper plates (X436 - X440 and X453 - X458) were cut in half with wire electric discharge machining (EDM) after which the deformation due to stress relaxation was measured with coordinate measurement system. The measured data was then used as boundary displacement data for the FEM analyses, in which the corresponding residual stresses were calculated. Before giving the corresponding displacement boundary conditions to the FE models, the deformation data was processed and smoothed appropriately. The residual stress levels of the copper plates were found to be around 40 - 55 MPa at maximum. This corresponds to other reported residual stress measurements and current state of knowledge with this material in Posiva. (orig.)

  20. Thermal sensor properties of PANI(EB)–CSA ( = 0.4 ± 0.1 mol) polymer thin films

    Indian Academy of Sciences (India)

    T Prakash; S A K Narayan Dass; K Prem Nazeer

    2002-11-01

    Films of polyaniline(EB) doped with camphor sulfonic acid (CSA) from -cresol on glass substrates exhibit considerable metallic properties. Such polymer metallic films have thermal sensitivity superior to ceramic metal (Cermet) films, prepared by metallo organic deposition (MOD) technique on silicon substrates. These PANI(EB)–CSA ( = 0.5, 0.4, 0.3 mol) polymer films were developed through controlled temperature atmosphere 60 ± 2°C for 60 min, and with the help of temperature dependence of resistivity (ρ) values, high temperature coefficient of resistance (TCR) i.e. values, and figure of merit (ρ ) values of these films, thermal sensitivity were compared from that we observed. Among the three doping ratios the PANI(EB)–CSA$_{0.3 mol}$ film (4.4 m thick) on glass substrate resistivity (ρ) values in the range of 838–1699 .m with high TCR i.e. = 10,291 ppm/°C and figure of merit (ρ ) value in range of 8.62–17.48 m/°C seems to be the best. This paper deals with these superior thermal-sensing properties together with optical studies and surface topography by atomic force microscopy (AFM). These polymer films offer design advantages in developing ‘thin film polymer thermal sensor’.

  1. Elemental imaging of organic matter and associated metals in ore deposits using micro PIXE and micro-EBS

    Energy Technology Data Exchange (ETDEWEB)

    Fuchs, S., E-mail: fuchs@geomin.eu [Department of Earth and Planetary Science, McGill University, 3450 University Street, Montreal H3A 0E8 (Canada); Przybylowicz, W.J., E-mail: przybylowicz@tlabs.ac.za [Materials Research Department, iThemba LABS, National Research Foundation, P.O. Box 722, Somerset West 7129 (South Africa); AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, Al. A. Mickiewicza 30, 30-059 Krakow (Poland); Williams-Jones, A.E., E-mail: anthony.williams-jones@mcgill.ca [Department of Earth and Planetary Science, McGill University, 3450 University Street, Montreal H3A 0E8 (Canada)

    2014-01-01

    Micro-PIXE and micro-EBS analyses were carried out on samples from the Au–U-bearing Carbon Leader Reef of the Witwatersrand in South Africa to investigate the role of organic matter in the formation of this deposit. Micro-PIXE and Micro-EBS shows a very complex metal distribution within the bitumen nodules and their interstitial spaces. The style of the gold distribution and its association with epigenetic minerals (REE phosphates, phyllosilicates) indicates that all observed gold migrated in aqueous solution and precipitated by reduction on the surfaces of the bitumen nodules. Uraninite occurrences are confined to the bitumen nodules, which supports the argument of a uraninite paleo-placer; however the pervasive distribution of uranium also supports the argument that uraninite is derived from organo-metallic complexes. This study shows that micro-PIXE is a powerful tool to characterize metals associated with hydrocarbons. However, the organic matrix, the complexity of the obtained spectra and the small size of the minerals have significant influence on the reliability of the quantitative data. Due to highly variable amounts of heavy metals (U, Au, Pb) the obtained micro-EBS results are of questionable quality.

  2. Kank Is an EB1 interacting protein that localises to muscle-tendon attachment sites in Drosophila.

    Directory of Open Access Journals (Sweden)

    Sara M R Clohisey

    Full Text Available Little is known about how microtubules are regulated in different cell types during development. EB1 plays a central role in the regulation of microtubule plus ends. It directly binds to microtubule plus ends and recruits proteins which regulate microtubule dynamics and behaviour. We report the identification of Kank, the sole Drosophila orthologue of human Kank proteins, as an EB1 interactor that predominantly localises to embryonic attachment sites between muscle and tendon cells. Human Kank1 was identified as a tumour suppressor and has documented roles in actin regulation and cell polarity in cultured mammalian cells. We found that Drosophila Kank binds EB1 directly and this interaction is essential for Kank localisation to microtubule plus ends in cultured cells. Kank protein is expressed throughout fly development and increases during embryogenesis. In late embryos, it accumulates to sites of attachment between muscle and epidermal cells. A kank deletion mutant was generated. We found that the mutant is viable and fertile without noticeable defects. Further analysis showed that Kank is dispensable for muscle function in larvae. This is in sharp contrast to C. elegans in which the Kank orthologue VAB-19 is required for development by stabilising attachment structures between muscle and epidermal cells.

  3. Quantitative/Statistical Approach to Bullet-to-Firearm Identification with Consecutively Manufactured Barrels

    Energy Technology Data Exchange (ETDEWEB)

    Peter Striupaitis; R.E. Gaensslen

    2005-01-30

    Efforts to use objective image comparison and bullet scanning technologies to distinguish bullets from consecutively manufactured handgun barrels from two manufacturers gave mixed results. The ability of a technology to reliably distinguish between matching and non-matching bullets, where the non-matching bullets were as close in pattern to the matching ones as is probably possible, would provide evidence that the distinctions could be made ''objectively'', and independently of human eyes. That evidence is identical or very close to what seems to be needed to satisfy Daubert standards. It is fair to say that the FTI IBIS image comparison technology correctly distinguished between all the Springfield barrel bullets, and between most but not all of the HiPoint barrel bullets. In the HiPoint cases that were not distinguished 100% of the time, they would he distinguished correctly at least 83% of the time. These results, although obviously limited to the materials used in the comparisons, provide strong evidence that barrel-to-bullet matching is objectively reliable. The results with SciClops were less compelling. The results do not mean that bullet-to-barrel matching is not objectively reliable--rather, they mean that this version of the particular technology could not quite distinguish between these extremely similar yet different bullets as well as the image comparison technology did. In a number of cases, the numerical results made the correct distinctions, although they were close to one another. It is hard to say from this data that this technology differs in its ability to make distinctions between the manufacturers, because the results are very similar with both. The human examiner results were as expected. We did not expect any misidentifications, and there were not any. It would have been preferable to have a higher return rate, and thus more comparisons in the overall sample. As noted, the ''consecutively manufactured barrel

  4. Anisotropic TGO rumpling in EB-PVD thermal barrier coatings under in-phase thermomechanical loading

    International Nuclear Information System (INIS)

    An electron beam physical vapor deposited (EB-PVD) Y2O3-ZrO2 thermal barrier system has been tested under in-phase thermomechanical fatigue (TMF) conditions with thermal gradient in the through-thickness direction. Undulations in the thermally grown oxide (TGO) were observed to have clear anisotropic behavior with respect to the directions parallel and perpendicular to the loading axis. It was found that undulation wavelengths were nearly the same in both directions but the amplitude in the perpendicular direction was much larger than in the parallel direction. A recent model of TGO rumpling was adapted and used to analyze and explain the origins of the observed rumpling behavior under TMF conditions. Methods for deducing variation in the coefficient of thermal expansion with temperature and in the creep properties of the substrate from the experimental strain data are also presented in the course of the derivations. Model results show that tensile stress applied in the loading direction can overcome the compression occurring from lateral expansion during oxide formation, causing undulations to flatten; undulations perpendicular to the loading axis are unaffected. However, ratcheting in the strain cycle experienced by the substrate, which occurs naturally by substrate creep, is necessary for anisotropic rumpling under cyclic stress conditions. Model predictions for constant applied stress are also presented, demonstrating a reversal in the direction of undulation alignment under compression. A threshold stress is identified, in both tension and compression, sufficient to produce appreciable anisotropic rumpling. The model predictions provide a clear mechanism for the anisotropy and further evidence that the lateral expansion strain in the oxide is the driving force for oxide rumpling.

  5. [Heinike Heinsoo. Mā ja pūd lēväd, meid eb lē : the subject and the predicate in Votic] / Johanna Laakso

    Index Scriptorium Estoniae

    Laakso, Johanna, 1962-

    2012-01-01

    Arvustus: Heinike Heinsoo. Mā ja pūd lēväd, meid eb lē : the subject and the predicate in Votic. Tallinn : Teaduste Akadeemia Kirjastus, 2010. (Linguistica Uralica. Supplementary series ; vol. 4)

  6. [Heinike Heinsoo. Mā ja pūd lēväd, meid eb lē] / Fedor Rozhanskiy

    Index Scriptorium Estoniae

    Rozhanskiy, Fedor

    2013-01-01

    Arvustus: Heinike Heinsoo. Mā ja pūd lēväd, meid eb lē : the subject and the predicate in Votic. Tallinn : Teaduste Akadeemia Kirjastus, 2010. (Linguistica Uralica. Supplementary series ; vol. 4)

  7. Cobalamin-Independent Methionine Synthase (MetE): A Face-to-Face Double Barrel that Evolved by Gene Duplication

    Energy Technology Data Exchange (ETDEWEB)

    Pejcha, Robert; Ludwig, Martha L. (Michigan)

    2010-03-08

    Cobalamin-independent methionine synthase (MetE) catalyzes the transfer of a methyl group from methyltetrahydrofolate to L-homocysteine (Hcy) without using an intermediate methyl carrier. Although MetE displays no detectable sequence homology with cobalamin-dependent methionine synthase (MetH), both enzymes require zinc for activation and binding of Hcy. Crystallographic analyses of MetE from T. maritima reveal an unusual dual-barrel structure in which the active site lies between the tops of the two ({beta}{alpha}){sub 8} barrels. The fold of the N-terminal barrel confirms that it has evolved from the C-terminal polypeptide by gene duplication; comparisons of the barrels provide an intriguing example of homologous domain evolution in which binding sites are obliterated. The C-terminal barrel incorporates the zinc ion that binds and activates Hcy. The zinc-binding site in MetE is distinguished from the (Cys){sub 3}Zn site in the related enzymes, MetH and betaine-homocysteine methyltransferase, by its position in the barrel and by the metal ligands, which are histidine, cysteine, glutamate, and cysteine in the resting form of MetE. Hcy associates at the face of the metal opposite glutamate, which moves away from the zinc in the binary E {center_dot} Hcy complex. The folate substrate is not intimately associated with the N-terminal barrel; instead, elements from both barrels contribute binding determinants in a binary complex in which the folate substrate is incorrectly oriented for methyl transfer. Atypical locations of the Hcy and folate sites in the C-terminal barrel presumably permit direct interaction of the substrates in a ternary complex. Structures of the binary substrate complexes imply that rearrangement of folate, perhaps accompanied by domain rearrangement, must occur before formation of a ternary complex that is competent for methyl transfer.

  8. Nissui Glucose Fermentative Gram-Negative Rod Identification System EB-20 Gives a Unique Profile for Typical Non-Sorbitol-Fermenting Escherichia coli O157:H7

    OpenAIRE

    Kodaka, H; Uesaka, Y; Kashitani, F

    2004-01-01

    The 98 non-sorbitol-fermenting (NSF) Escherichia coli O157:H7 strains identified on a Nissui glucose fermentative gram-negative rod identification system (EB-20) gave a unique biochemical profile number that was not detected in 85 pathogenic and 13 nonpathogenic E. coli strains. Thus, EB-20 is useful for the identification of NSF E. coli O157:H7 and provides a simple, cost-effective, and reliable tool for clinical laboratories.

  9. Synaptic molecular imaging in spared and deprived columns of mouse barrel cortex with array tomography.

    Science.gov (United States)

    Weiler, Nicholas C; Collman, Forrest; Vogelstein, Joshua T; Burns, Randal; Smith, Stephen J

    2014-01-01

    A major question in neuroscience is how diverse subsets of synaptic connections in neural circuits are affected by experience dependent plasticity to form the basis for behavioral learning and memory. Differences in protein expression patterns at individual synapses could constitute a key to understanding both synaptic diversity and the effects of plasticity at different synapse populations. Our approach to this question leverages the immunohistochemical multiplexing capability of array tomography (ATomo) and the columnar organization of mouse barrel cortex to create a dataset comprising high resolution volumetric images of spared and deprived cortical whisker barrels stained for over a dozen synaptic molecules each. These dataset has been made available through the Open Connectome Project for interactive online viewing, and may also be downloaded for offline analysis using web, Matlab, and other interfaces. PMID:25977797

  10. Current Status of the Pixel Phase I Upgrade in CMS: Barrel Module Production

    CERN Document Server

    Bartek, Rachel

    2015-01-01

    The silicon pixel detector is the innermost component of the CMS tracking system, providing high precision space point measurements of charged particle trajectories. Before 2018 the instantaneous luminosity of the LHC is expected to reach about 2~x~$10^{34}~\\rm{cm}^{-2}\\rm{s}^{-1}$, which will significantly increase the number of interactions per bunch crossing. To maintain a high tracking efficiency, CMS has planned to replace the current pixel system during phase I by a new lightweight detector, equipped with an additional 4th layer in the barrel, and one additional forward/backward disk. The present status of barrel modules production will be presented, including preliminary results from tests on the first production pixel modules of the new pixel tracker.

  11. The protection system of the superconducting coils in the Barrel Toroid of ATLAS

    CERN Document Server

    Acerbi, E; Volpini, G; Daël, A; Lesmond, C

    1999-01-01

    An analysis of the discharge of the Barrel Toroid under several operating conditions has been carried out. The main critical parameters of the discharge (i.e. the maximum temperature inside the coils, the maximum temperature $9 gradient, the maximum voltage at the coil ends and the maximum decentering forces acting on the BT and ECT magnets) have been calculated for several operating conditions (heaters on, heaters off, short circuit with heaters on or $9 off). The aim of this analysis is to provide a cross check of the protection design of the Barrel Toroid coils with an independent study. The results validate the choice to use a low value of dump resistance, and give some important $9 warning in the case of heater failure or presence of a short circuit. (5 refs).

  12. Barrel-stave model or toroidal model? A case study on melittin pores.

    OpenAIRE

    Yang, L; Harroun, T A; Weiss, T M; Ding, L; Huang, H W

    2001-01-01

    Transmembrane pores induced by amphiphilic peptides, including melittin, are often modeled with the barrel-stave model after the alamethicin pore. We examine this assumption on melittin by using two methods, oriented circular dichroism (OCD) for detecting the orientation of melittin helix and neutron scattering for detecting transmembrane pores. OCD spectra of melittin were systematically measured. Melittin can orient either perpendicularly or parallel to a lipid bilayer, depending on the phy...

  13. Test Beam Measurement of the Crosstalk in the EM Barrel Module 0

    CERN Document Server

    Hubaut, F; Lacour, D; Orsini, F

    2000-01-01

    Test beam measurements of the crosstalk in the barrel electromagnetic calorimeter Module 0 tested at CERN in August 99' are reported. The main sources of crosstalk coming either from electronics or from physical effects on the electrodes have been identified and quantified. This has been done for the crosstalks between the different parts of the module, namely middle-middle, middle-back, middle-front, back-back, back-middle, back-front, front-front and front-middle.

  14. Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex

    OpenAIRE

    Avermann, Michael; Tomm, Christian; Mateo, Celine; Gerstner, Wulfram; Petersen, Carl C. H.

    2012-01-01

    Avermann M, Tomm C, Mateo C, Gerstner W, Petersen CC. Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex. J Neurophysiol 107: 3116-3134, 2012. First published March 7, 2012; doi:10.1152/jn.00917.2011.-Synaptic interactions between nearby excitatory and inhibitory neurons in the neocortex are thought to play fundamental roles in sensory processing. Here, we have combined optogenetic stimulation, whole cell recordings, and computational modeling to define key...

  15. Study of a twisted ATLAS SCT Barrel deformation as revealed by a photogrammetric survey

    CERN Document Server

    Dobson, E; Heinemann, F; Karagoz-Unel, M

    2007-01-01

    A photogrammetry survey on the SCT barrels was performed as an engineering check on the structure of the ATLAS Semiconductor Tracker (SCT) shortly after construction. Analysis of the data obtained revealed small scale elliptical deformation as well as a twist of the structure. The results of the survey are presented as well as interpolation of the measured targets to the module positions and a comparison with track based alignment measurements.

  16. Structural Plasticity within the Barrel Cortex during Initial Phases of Whisker-Dependent Learning

    OpenAIRE

    Kuhlman, Sandra J.; O'Connor, Daniel H.; Fox, Kevin; Svoboda, Karel

    2014-01-01

    We report learning-related structural plasticity in layer 1 branches of pyramidal neurons in the barrel cortex, a known site of sensorimotor integration. In mice learning an active, whisker-dependent object localization task, layer 2/3 neurons showed enhanced spine growth during initial skill acquisition that both preceded and predicted expert performance. Preexisting spines were stabilized and new persistent spines were formed. These findings suggest rapid changes in connectivity between mot...

  17. A Study of Bernard Malamud’s The Magic Barrel from the Psychological Approach

    Institute of Scientific and Technical Information of China (English)

    田婧

    2014-01-01

    The Magic Barrel tells a story about Leo Finkle who is a rabbinical student and in want of a wife transacts with the marriage broker Pinye Salzman and finally marry his daughter Stella. By using Sigmund Freud’s Psychoanalytical Criti-cism, this paper aims to explore the Leo’s changes in thought and emotions towards love and marriage and his torment during his process of the pursuit of love and happiness.

  18. Morphology and Physiology of Excitatory Neurons in Layer 6b of the Somatosensory Rat Barrel Cortex

    OpenAIRE

    M. Marx; Feldmeyer, D.

    2012-01-01

    Neocortical lamina 6B (L6B) is a largely unexplored layer with a very heterogeneous cellular composition. To date, only little is known about L6B neurons on a systematic and quantitative basis. We investigated the morphological and electrophysiological properties of excitatory L6B neurons in the rat somatosensory barrel cortex using whole-cell patch-clamp recordings and simultaneous biocytin fillings. Subsequent histological processing and computer-assisted 3D reconstructions provided the bas...

  19. Adoption, Maintenance and Diffusion of Stormwater Best Management Practices: Rain Barrels

    OpenAIRE

    Hoffa, Cheyenne R; Prokopy, Linda S; Babin, Nicholas, Ph. D; Turner, Allison J

    2014-01-01

    Urbanization increases the volume of stormwater runoff from homes, businesses and other paved areas of the urbanized landscape. Unable to infiltrate into the ground, stormwater is directed to facilities that can easily become overloaded and cause a variety of water quality issues. This study aims to assess urban homeowners’ motivations to adopt and maintain rain barrels, a stormwater best management practice (BMP), and evaluate how this BMP diffuses throughout a community. This research took ...

  20. Nitrobindin: An Ubiquitous Family of All β-Barrel Heme-proteins.

    Science.gov (United States)

    De Simone, Giovanna; Ascenzi, Paolo; Polticelli, Fabio

    2016-06-01

    Rhodnius prolixus nitrophorins (Rp-NPs), Arabidopsis thaliana nitrobindin (At-Nb), and Homo sapiens THAP4 (Hs-THAP4) are the unique known proteins that use a β-barrel fold to bind ferric heme, which is devoted to NO transport and/or catalysis. The eight-stranded antiparallel β-barrel Rp-NPs, which represent the only heme-binding lipocalins, are devoted to deliver NO into the blood vessel of the host and to scavenge histamine during blood sucking. Regarding Nbs, crystallographic data suggest the ability of At-Nb and Hs-THAP4 to bind ferric heme; however, no data are available with respect to these functions in the natural host. Here, a bioinformatics investigation based on the amino acid sequences and three-dimensional structures of At-Nb and Hs-THAP4 suggests a conservation of the 10-stranded antiparallel β-barrel Nb structural module in all life kingdoms of the evolutionary ladder. In particular, amino acid residues involved in the heme recognition and in the structure stabilization of the Nb structural module are highly conserved (identity > 29%; homology > 83%). Moreover, molecular models of putative Nbs from different organisms match very well with each other and known three-dimensional structures of Nbs. Furthermore, phylogenetic tree reconstruction indicates that NPs and Nbs group in distinct clades. These data indicate that 10-stranded β-barrel Nbs constitute a new ubiquitous heme protein family spanning from bacteria to Homo sapiens. © 2016 IUBMB Life, 68(6):423-428, 2016. PMID:27080126

  1. Performance Study of the CMS Barrel Resistive Plate Chambers with Cosmic Rays

    CERN Document Server

    Chatrchyan, S; Sirunyan, A M; Adam, W; Arnold, B; Bergauer, H; Bergauer, T; Dragicevic, M; Eichberger, M; Erö, J; Friedl, M; Frühwirth, R; Ghete, V M; Hammer, J; Hänsel, S; Hoch, M; Hörmann, N; Hrubec, J; Jeitler, M; Kasieczka, G; Kastner, K; Krammer, M; Liko, D; Magrans de Abril, I; Mikulec, I; Mittermayr, F; Neuherz, B; Oberegger, M; Padrta, M; Pernicka, M; Rohringer, H; Schmid, S; Schöfbeck, R; Schreiner, T; Stark, R; Steininger, H; Strauss, J; Taurok, A; Teischinger, F; Themel, T; Uhl, D; Wagner, P; Waltenberger, W; Walzel, G; Widl, E; Wulz, C E; Chekhovsky, V; Dvornikov, O; Emeliantchik, I; Litomin, A; Makarenko, V; Marfin, I; Mossolov, V; Shumeiko, N; Solin, A; Stefanovitch, R; Suarez Gonzalez, J; Tikhonov, A; Fedorov, A; Karneyeu, A; Korzhik, M; Panov, V; Zuyeuski, R; Kuchinsky, P; Beaumont, W; Benucci, L; Cardaci, M; De Wolf, E A; Delmeire, E; Druzhkin, D; Hashemi, M; Janssen, X; Maes, T; Mucibello, L; Ochesanu, S; Rougny, R; Selvaggi, M; Van Haevermaet, H; Van Mechelen, P; Van Remortel, N; Adler, V; Beauceron, S; Blyweert, S; D'Hondt, J; De Weirdt, S; Devroede, O; Heyninck, J; Kalogeropoulos, A; Maes, J; Maes, M; Mozer, M U; Tavernier, S; Van Doninck, W; Van Mulders, P; Villella, I; Bouhali, O; Chabert, E C; Charaf, O; Clerbaux, B; De Lentdecker, G; Dero, V; Elgammal, S; Gay, A P R; Hammad, G H; Marage, P E; Rugovac, S; Vander Velde, C; Vanlaer, P; Wickens, J; Grunewald, M; Klein, B; Marinov, A; Ryckbosch, D; Thyssen, F; Tytgat, M; Vanelderen, L; Verwilligen, P; Basegmez, S; Bruno, G; Caudron, J; Delaere, C; Demin, P; Favart, D; Giammanco, A; Grégoire, G; Lemaitre, V; Militaru, O; Ovyn, S; Piotrzkowski, K; Quertenmont, L; Schul, N; Beliy, N; Daubie, E; Alves, G A; Pol, M E; Souza, M H G; Carvalho, W; De Jesus Damiao, D; De Oliveira Martins, C; Fonseca De Souza, S; Mundim, L; Oguri, V; Santoro, A; Silva Do Amaral, S M; Sznajder, A; Fernandez Perez Tomei, T R; Ferreira Dias, M A; Gregores, E M; Novaes, S F; Abadjiev, K; Anguelov, T; Damgov, J; Darmenov, N; Dimitrov, L; Genchev, V; Iaydjiev, P; Piperov, S; Stoykova, S; Sultanov, G; Trayanov, R; Vankov, I; Dimitrov, A; Dyulendarova, M; Kozhuharov, V; Litov, L; Marinova, E; Mateev, M; Pavlov, B; Petkov, P; Toteva, Z; Chen, G M; Chen, H S; Guan, W; Jiang, C H; Liang, D; Liu, B; Meng, X; Tao, J; Wang, J; Wang, Z; Xue, Z; Zhang, Z; Ban, Y; Cai, J; Ge, Y; Guo, S; Hu, Z; Mao, Y; Qian, S J; Teng, H; Zhu, B; Avila, C; Baquero Ruiz, M; Carrillo Montoya, C A; Gomez, A; Gomez Moreno, B; Ocampo Rios, A A; Osorio Oliveros, A F; Reyes Romero, D; Sanabria, J C; Godinovic, N; Lelas, K; Plestina, R; Polic, D; Puljak, I; Antunovic, Z; Dzelalija, M; Brigljevic, V; Duric, S; Kadija, K; Morovic, S; Fereos, R; Galanti, M; Mousa, J; Papadakis, A; Ptochos, F; Razis, P A; Tsiakkouri, D; Zinonos, Z; Hektor, A; Kadastik, M; Kannike, K; Müntel, M; Raidal, M; Rebane, L; Anttila, E; Czellar, S; Härkönen, J; Heikkinen, A; Karimäki, V; Kinnunen, R; Klem, J; Kortelainen, M J; Lampén, T; Lassila-Perini, K; Lehti, S; Lindén, T; Luukka, P; Mäenpää, T; Nysten, J; Tuominen, E; Tuominiemi, J; Ungaro, D; Wendland, L; Banzuzi, K; Korpela, A; Tuuva, T; Nedelec, P; Sillou, D; Besancon, M; Chipaux, R; Dejardin, M; Denegri, D; Descamps, J; Fabbro, B; Faure, J L; Ferri, F; Ganjour, S; Gentit, F X; Givernaud, A; Gras, P; Hamel de Monchenault, G; Jarry, P; Lemaire, M C; Locci, E; Malcles, J; Marionneau, M; Millischer, L; Rander, J; Rosowsky, A; Rousseau, D; Titov, M; Verrecchia, P; Baffioni, S; Bianchini, L; Bluj, M; Busson, P; Charlot, C; Dobrzynski, L; Granier de Cassagnac, R; Haguenauer, M; Miné, P; Paganini, P; Sirois, Y; Thiebaux, C; Zabi, A; Agram, J L; Besson, A; Bloch, D; Bodin, D; Brom, J M; Conte, E; Drouhin, F; Fontaine, J C; Gelé, D; Goerlach, U; Gross, L; Juillot, P; Le Bihan, A C; Patois, Y; Speck, J; Van Hove, P; Baty, C; Bedjidian, M; Blaha, J; Boudoul, G; Brun, H; Chanon, N; Chierici, R; Contardo, D; Depasse, P; Dupasquier, T; El Mamouni, H; Fassi, F; Fay, J; Gascon, S; Ille, B; Kurca, T; Le Grand, T; Lethuillier, M; Lumb, N; Mirabito, L; Perries, S; Vander Donckt, M; Verdier, P; Djaoshvili, N; Roinishvili, N; Roinishvili, V; Amaglobeli, N; Adolphi, R; Anagnostou, G; Brauer, R; Braunschweig, W; Edelhoff, M; Esser, H; Feld, L; Karpinski, W; Khomich, A; Klein, K; Mohr, N; Ostaptchouk, A; Pandoulas, D; Pierschel, G; Raupach, F; Schael, S; Schultz von Dratzig, A; Schwering, G; Sprenger, D; Thomas, M; Weber, M; Wittmer, B; Wlochal, M; Actis, O; Altenhöfer, G; Bender, W; Biallass, P; Erdmann, M; Fetchenhauer, G; Frangenheim, J; Hebbeker, T; Hilgers, G; Hinzmann, A; Hoepfner, K; Hof, C; Kirsch, M; Klimkovich, T; Kreuzer, P; Lanske, D; Merschmeyer, M; Meyer, A; Philipps, B; Pieta, H; Reithler, H; Schmitz, S A; Sonnenschein, L; Sowa, M; Steggemann, J; Szczesny, H; Teyssier, D; Zeidler, C; Bontenackels, M; Davids, M; Duda, M; Flügge, G; Geenen, H; Giffels, M; Haj Ahmad, W; Hermanns, T; Heydhausen, D; Kalinin, S; Kress, T; Linn, A; Nowack, A; Perchalla, L; Poettgens, M; Pooth, O; Sauerland, P; Stahl, A; Tornier, D; Zoeller, M H; Aldaya Martin, M; Behrens, U; Borras, K; Campbell, A; Castro, E; Dammann, D; Eckerlin, G; Flossdorf, A; Flucke, G; Geiser, A; Hatton, D; Hauk, J; Jung, H; Kasemann, M; Katkov, I; Kleinwort, C; Kluge, H; Knutsson, A; Kuznetsova, E; Lange, W; Lohmann, W; Mankel, R; Marienfeld, M; Meyer, A B; Miglioranzi, S; Mnich, J; Ohlerich, M; Olzem, J; Parenti, A; Rosemann, C; Schmidt, R; Schoerner-Sadenius, T; Volyanskyy, D; Wissing, C; Zeuner, W D; Autermann, C; Bechtel, F; Draeger, J; Eckstein, D; Gebbert, U; Kaschube, K; Kaussen, G; Klanner, R; Mura, B; Naumann-Emme, S; Nowak, F; Pein, U; Sander, C; Schleper, P; Schum, T; Stadie, H; Steinbrück, G; Thomsen, J; Wolf, R; Bauer, J; Blüm, P; Buege, V; Cakir, A; Chwalek, T; De Boer, W; Dierlamm, A; Dirkes, G; Feindt, M; Felzmann, U; Frey, M; Furgeri, A; Gruschke, J; Hackstein, C; Hartmann, F; Heier, S; Heinrich, M; Held, H; Hirschbuehl, D; Hoffmann, K H; Honc, S; Jung, C; Kuhr, T; Liamsuwan, T; Martschei, D; Mueller, S; Müller, Th; Neuland, M B; Niegel, M; Oberst, O; Oehler, A; Ott, J; Peiffer, T; Piparo, D; Quast, G; Rabbertz, K; Ratnikov, F; Ratnikova, N; Renz, M; Saout, C; Sartisohn, G; Scheurer, A; Schieferdecker, P; Schilling, F P; Schott, G; Simonis, H J; Stober, F M; Sturm, P; Troendle, D; Trunov, A; Wagner, W; Wagner-Kuhr, J; Zeise, M; Zhukov, V; Ziebarth, E B; Daskalakis, G; Geralis, T; Karafasoulis, K; Kyriakis, A; Loukas, D; Markou, A; Markou, C; Mavrommatis, C; Petrakou, E; Zachariadou, A; Gouskos, L; Katsas, P; Panagiotou, A; Evangelou, I; Kokkas, P; Manthos, N; Papadopoulos, I; Patras, V; Triantis, F A; Bencze, G; Boldizsar, L; Debreczeni, G; Hajdu, C; Hernath, S; Hidas, P; Horvath, D; Krajczar, K; Laszlo, A; Patay, G; Sikler, F; Toth, N; Vesztergombi, G; Beni, N; Christian, G; Imrek, J; Molnar, J; Novak, D; Palinkas, J; Szekely, G; Szillasi, Z; Tokesi, K; Veszpremi, V; Kapusi, A; Marian, G; Raics, P; Szabo, Z; Trocsanyi, Z L; Ujvari, B; Zilizi, G; Bansal, S; Bawa, H S; Beri, S B; Bhatnagar, V; Jindal, M; Kaur, M; Kaur, R; Kohli, J M; Mehta, M Z; Nishu, N; Saini, L K; Sharma, A; Singh, A; Singh, J B; Singh, S P; Ahuja, S; Arora, S; Bhattacharya, S; Chauhan, S; Choudhary, B C; Gupta, P; Jain, S; Jain, S; Jha, M; Kumar, A; Ranjan, K; Shivpuri, R K; Srivastava, A K; Choudhury, R K; Dutta, D; Kailas, S; Kataria, S K; Mohanty, A K; Pant, L M; Shukla, P; Topkar, A; Aziz, T; Guchait, M; Gurtu, A; Maity, M; Majumder, D; Majumder, G; Mazumdar, K; Nayak, A; Saha, A; Sudhakar, K; Banerjee, S; Dugad, S; Mondal, N K; Arfaei, H; Bakhshiansohi, H; Fahim, A; Jafari, A; Mohammadi Najafabadi, M; Moshaii, A; Paktinat Mehdiabadi, S; Rouhani, S; Safarzadeh, B; Zeinali, M; Felcini, M; Abbrescia, M; Barbone, L; Chiumarulo, F; Clemente, A; Colaleo, A; Creanza, D; Cuscela, G; De Filippis, N; De Palma, M; De Robertis, G; Donvito, G; Fedele, F; Fiore, L; Franco, M; Iaselli, G; Lacalamita, N; Loddo, F; Lusito, L; Maggi, G; Maggi, M; Manna, N; Marangelli, B; My, S; Natali, S; Nuzzo, S; Papagni, G; Piccolomo, S; Pierro, G A; Pinto, C; Pompili, A; Pugliese, G; Rajan, R; Ranieri, A; Romano, F; Roselli, G; Selvaggi, G; Shinde, Y; Silvestris, L; Tupputi, S; Zito, G; Abbiendi, G; Bacchi, W; Benvenuti, A C; Boldini, M; Bonacorsi, D; Braibant-Giacomelli, S; Cafaro, V D; Caiazza, S S; Capiluppi, P; Castro, A; Cavallo, F R; Codispoti, G; Cuffiani, M; D'Antone, I; Dallavalle, G M; Fabbri, F; Fanfani, A; Fasanella, D; Giacomelli, P; Giordano, V; Giunta, M; Grandi, C; Guerzoni, M; Marcellini, S; Masetti, G; Montanari, A; Navarria, F L; Odorici, F; Pellegrini, G; Perrotta, A; Rossi, A M; Rovelli, T; Siroli, G; Torromeo, G; Travaglini, R; Albergo, S; Costa, S; Potenza, R; Tricomi, A; Tuve, C; Barbagli, G; Broccolo, G; Ciulli, V; Civinini, C; D'Alessandro, R; Focardi, E; Frosali, S; Gallo, E; Genta, C; Landi, G; Lenzi, P; Meschini, M; Paoletti, S; Sguazzoni, G; Tropiano, A; Benussi, L; Bertani, M; Bianco, S; Colafranceschi, S; Colonna, D; Fabbri, F; Giardoni, M; Passamonti, L; Piccolo, D; Pierluigi, D; Ponzio, B; Russo, A; Fabbricatore, P; Musenich, R; Benaglia, A; Calloni, M; Cerati, G B; D'Angelo, P; De Guio, F; Farina, F M; Ghezzi, A; Govoni, P; Malberti, M; Malvezzi, S; Martelli, A; Menasce, D; Miccio, V; Moroni, L; Negri, P; Paganoni, M; Pedrini, D; Pullia, A; Ragazzi, S; Redaelli, N; Sala, S; Salerno, R; Tabarelli de Fatis, T; Tancini, V; Taroni, S; Buontempo, S; Cavallo, N; Cimmino, A; De Gruttola, M; Fabozzi, F; Iorio, A O M; Lista, L; Lomidze, D; Noli, P; Paolucci, P; Sciacca, C; Azzi, P; Bacchetta, N; Barcellan, L; Bellan, P; Bellato, M; Benettoni, M; Biasotto, M; Bisello, D; Borsato, E; Branca, A; Carlin, R; Castellani, L; Checchia, P; Conti, E; Dal Corso, F; De Mattia, M; Dorigo, T; Dosselli, U; Fanzago, F; Gasparini, F; Gasparini, U; Giubilato, P; Gonella, F; Gresele, A; Gulmini, M; Kaminskiy, A; Lacaprara, S; Lazzizzera, I; Margoni, M; Maron, G; Mattiazzo, S; Mazzucato, M; Meneghelli, M; Meneguzzo, A T; Michelotto, M; Montecassiano, F; Nespolo, M; Passaseo, M; Pegoraro, M; Perrozzi, L; Pozzobon, N; Ronchese, P; Simonetto, F; Toniolo, N; Torassa, E; Tosi, M; Triossi, A; Vanini, S; Ventura, S; Zotto, P; Zumerle, G; Baesso, P; Berzano, U; Bricola, S; Necchi, M M; Pagano, D; Ratti, S P; Riccardi, C; Torre, P; Vicini, A; Vitulo, P; Viviani, C; Aisa, D; Aisa, S; Babucci, E; Biasini, M; Bilei, G M; Caponeri, B; Checcucci, B; Dinu, N; Fanò, L; Farnesini, L; Lariccia, P; Lucaroni, A; Mantovani, G; Nappi, A; Piluso, A; Postolache, V; Santocchia, A; Servoli, L; Tonoiu, D; Vedaee, A; Volpe, R; Azzurri, P; Bagliesi, G; Bernardini, J; Berretta, L; Boccali, T; Bocci, A; Borrello, L; Bosi, F; Calzolari, F; Castaldi, R; Dell'Orso, R; Fiori, F; Foà, L; Gennai, S; Giassi, A; Kraan, A; Ligabue, F; Lomtadze, T; Mariani, F; Martini, L; Massa, M; Messineo, A; Moggi, A; Palla, F; Palmonari, F; Petragnani, G; Petrucciani, G; Raffaelli, F; Sarkar, S; Segneri, G; Serban, A T; Spagnolo, P; Tenchini, R; Tolaini, S; Tonelli, G; Venturi, A; Verdini, P G; Baccaro, S; Barone, L; Bartoloni, A; Cavallari, F; Dafinei, I; Del Re, D; Di Marco, E; Diemoz, M; Franci, D; Longo, E; Organtini, G; Palma, A; Pandolfi, F; Paramatti, R; Pellegrino, F; Rahatlou, S; Rovelli, C; Alampi, G; Amapane, N; Arcidiacono, R; Argiro, S; Arneodo, M; Biino, C; Borgia, M A; Botta, C; Cartiglia, N; Castello, R; Cerminara, G; Costa, M; Dattola, D; Dellacasa, G; Demaria, N; Dughera, G; Dumitrache, F; Graziano, A; Mariotti, C; Marone, M; Maselli, S; Migliore, E; Mila, G; Monaco, V; Musich, M; Nervo, M; Obertino, M M; Oggero, S; Panero, R; Pastrone, N; Pelliccioni, M; Romero, A; Ruspa, M; Sacchi, R; Solano, A; Staiano, A; Trapani, P P; Trocino, D; Vilela Pereira, A; Visca, L; Zampieri, A; Ambroglini, F; Belforte, S; Cossutti, F; Della Ricca, G; Gobbo, B; Penzo, A; Chang, S; Chung, J; Kim, D H; Kim, G N; Kong, D J; Park, H; Son, D C; Bahk, S Y; Song, S; Jung, S Y; Hong, B; Kim, H; Kim, J H; Lee, K S; Moon, D H; Park, S K; Rhee, H B; Sim, K S; Kim, J; Choi, M; Hahn, G; Park, I C; Choi, S; Choi, Y; Goh, J; Jeong, H; Kim, T J; Lee, J; Lee, S; Janulis, M; Martisiute, D; Petrov, P; Sabonis, T; Castilla Valdez, H; Sánchez Hernández, A; Carrillo Moreno, S; Morelos Pineda, A; Allfrey, P; Gray, R N C; Krofcheck, D; Bernardino Rodrigues, N; Butler, P H; Signal, T; Williams, J C; Ahmad, M; Ahmed, I; Ahmed, W; Asghar, M I; Awan, M I M; Hoorani, H R; Hussain, I; Khan, W A; Khurshid, T; Muhammad, S; Qazi, S; Shahzad, H; Cwiok, M; Dabrowski, R; Dominik, W; Doroba, K; Konecki, M; Krolikowski, J; Pozniak, K; Romaniuk, Ryszard; Zabolotny, W; Zych, P; Frueboes, T; Gokieli, R; Goscilo, L; Górski, M; Kazana, M; Nawrocki, K; Szleper, M; Wrochna, G; Zalewski, P; Almeida, N; Antunes Pedro, L; Bargassa, P; David, A; Faccioli, P; Ferreira Parracho, P G; Freitas Ferreira, M; Gallinaro, M; Guerra Jordao, M; Martins, P; Mini, G; Musella, P; Pela, J; Raposo, L; Ribeiro, P Q; Sampaio, S; Seixas, J; Silva, J; Silva, P; Soares, D; Sousa, M; Varela, J; Wöhri, H K; Altsybeev, I; Belotelov, I; Bunin, P; Ershov, Y; Filozova, I; Finger, M; Finger, M Jr; Golunov, A; Golutvin, I; Gorbounov, N; Kalagin, V; Kamenev, A; Karjavin, V; Konoplyanikov, V; Korenkov, V; Kozlov, G; Kurenkov, A; Lanev, A; Makankin, A; Mitsyn, V V; Moisenz, P; Nikonov, E; Oleynik, D; Palichik, V; Perelygin, V; Petrosyan, A; Semenov, R; Shmatov, S; Smirnov, V; Smolin, D; Tikhonenko, E; Vasil'ev, S; Vishnevskiy, A; Volodko, A; Zarubin, A; Zhiltsov, V; Bondar, N; Chtchipounov, L; Denisov, A; Gavrikov, Y; Gavrilov, G; Golovtsov, V; Ivanov, Y; Kim, V; Kozlov, V; Levchenko, P; Obrant, G; Orishchin, E; Petrunin, A; Shcheglov, Y; Shchetkovskiy, A; Sknar, V; Smirnov, I; Sulimov, V; Tarakanov, V; Uvarov, L; Vavilov, S; Velichko, G; Volkov, S; Vorobyev, A; Andreev, Yu; Anisimov, A; Antipov, P; Dermenev, A; Gninenko, S; Golubev, N; Kirsanov, M; Krasnikov, N; Matveev, V; Pashenkov, A; Postoev, V E; Solovey, A; Solovey, A; Toropin, A; Troitsky, S; Baud, A; Epshteyn, V; Gavrilov, V; Ilina, N; Kaftanov, V; Kolosov, V; Kossov, M; Krokhotin, A; Kuleshov, S; Oulianov, A; Safronov, G; Semenov, S; Shreyber, I; Stolin, V; Vlasov, E; Zhokin, A; Boos, E; Dubinin, M; Dudko, L; Ershov, A; Gribushin, A; Klyukhin, V; Kodolova, O; Lokhtin, I; Petrushanko, S; Sarycheva, L; Savrin, V; Snigirev, A; Vardanyan, I; Dremin, I; Kirakosyan, M; Konovalova, N; Rusakov, S V; Vinogradov, A; Akimenko, S; Artamonov, A; Azhgirey, I; Bitioukov, S; Burtovoy, V; Grishin, V; Kachanov, V; Konstantinov, D; Krychkine, V; Levine, A; Lobov, I; Lukanin, V; Mel'nik, Y; Petrov, V; Ryutin, R; Slabospitsky, S; Sobol, A; Sytine, A; Tourtchanovitch, L; Troshin, S; Tyurin, N; Uzunian, A; Volkov, A; Adzic, P; Djordjevic, M; Jovanovic, D; Krpic, D; Maletic, D; Puzovic, J; Smiljkovic, N; Aguilar-Benitez, M; Alberdi, J; Alcaraz Maestre, J; Arce, P; Barcala, J M; Battilana, C; Burgos Lazaro, C; Caballero Bejar, J; Calvo, E; Cardenas Montes, M; Cepeda, M; Cerrada, M; Chamizo Llatas, M; Clemente, F; Colino, N; Daniel, M; De La Cruz, B; Delgado Peris, A; Diez Pardos, C; Fernandez Bedoya, C; Fernández Ramos, J P; Ferrando, A; Flix, J; Fouz, M C; Garcia-Abia, P; Garcia-Bonilla, A C; Gonzalez Lopez, O; Goy Lopez, S; Hernandez, J M; Josa, M I; Marin, J; Merino, G; Molina, J; Molinero, A; Navarrete, J J; Oller, J C; Puerta Pelayo, J; Romero, L; Santaolalla, J; Villanueva Munoz, C; Willmott, C; Yuste, C; Albajar, C; Blanco Otano, M; de Trocóniz, J F; Garcia Raboso, A; Lopez Berengueres, J O; Cuevas, J; Fernandez Menendez, J; Gonzalez Caballero, I; Lloret Iglesias, L; Naves Sordo, H; Vizan Garcia, J M; Cabrillo, I J; Calderon, A; Chuang, S H; Diaz Merino, I; Diez Gonzalez, C; Duarte Campderros, J; Fernandez, M; Gomez, G; Gonzalez Sanchez, J; Gonzalez Suarez, R; Jorda, C; Lobelle Pardo, P; Lopez Virto, A; Marco, J; Marco, R; Martinez Rivero, C; Martinez Ruiz del Arbol, P; Matorras, F; Rodrigo, T; Ruiz Jimeno, A; Scodellaro, L; Sobron Sanudo, M; Vila, I; Vilar Cortabitarte, R; Abbaneo, D; Albert, E; Alidra, M; Ashby, S; Auffray, E; Baechler, J; Baillon, P; Ball, A H; Bally, S L; Barney, D; Beaudette, F; Bellan, R; Benedetti, D; Benelli, G; Bernet, C; Bloch, P; Bolognesi, S; Bona, M; Bos, J; Bourgeois, N; Bourrel, T; Breuker, H; Bunkowski, K; Campi, D; Camporesi, T; Cano, E; Cattai, A; Chatelain, J P; Chauvey, M; Christiansen, T; Coarasa Perez, J A; Conde Garcia, A; Covarelli, R; Curé, B; De Roeck, A; Delachenal, V; Deyrail, D; Di Vincenzo, S; Dos Santos, S; Dupont, T; Edera, L M; Elliott-Peisert, A; Eppard, M; Favre, M; Frank, N; Funk, W; Gaddi, A; Gastal, M; Gateau, M; Gerwig, H; Gigi, D; Gill, K; Giordano, D; Girod, J P; Glege, F; Gomez-Reino Garrido, R; Goudard, R; Gowdy, S; Guida, R; Guiducci, L; Gutleber, J; Hansen, M; Hartl, C; Harvey, J; Hegner, B; Hoffmann, H F; Holzner, A; Honma, A; Huhtinen, M; Innocente, V; Janot, P; Le Godec, G; Lecoq, P; Leonidopoulos, C; Loos, R; Lourenço, C; Lyonnet, A; Macpherson, A; Magini, N; Maillefaud, J D; Maire, G; Mäki, T; Malgeri, L; Mannelli, M; Masetti, L; Meijers, F; Meridiani, P; Mersi, S; Meschi, E; Meynet Cordonnier, A; Moser, R; Mulders, M; Mulon, J; Noy, M; Oh, A; Olesen, G; Onnela, A; Orimoto, T; Orsini, L; Perez, E; Perinic, G; Pernot, J F; Petagna, P; Petiot, P; Petrilli, A; Pfeiffer, A; Pierini, M; Pimiä, M; Pintus, R; Pirollet, B; Postema, H; Racz, A; Ravat, S; Rew, S B; Rodrigues Antunes, J; Rolandi, G; Rovere, M; Ryjov, V; Sakulin, H; Samyn, D; Sauce, H; Schäfer, C; Schlatter, W D; Schröder, M; Schwick, C; Sciaba, A; Segoni, I; Sharma, A; Siegrist, N; Siegrist, P; Sinanis, N; Sobrier, T; Sphicas, P; Spiga, D; Spiropulu, M; Stöckli, F; Traczyk, P; Tropea, P; Troska, J; Tsirou, A; Veillet, L; Veres, G I; Voutilainen, M; Wertelaers, P; Zanetti, M; Bertl, W; Deiters, K; Erdmann, W; Gabathuler, K; Horisberger, R; Ingram, Q; Kaestli, H C; König, S; Kotlinski, D; Langenegger, U; Meier, F; Renker, D; Rohe, T; Sibille, J; Starodumov, A; Betev, B; Caminada, L; Chen, Z; Cittolin, S; Da Silva Di Calafiori, D R; Dambach, S; Dissertori, G; Dittmar, M; Eggel, C; Eugster, J; Faber, G; Freudenreich, K; Grab, C; Hervé, A; Hintz, W; Lecomte, P; Luckey, P D; Lustermann, W; Marchica, C; Milenovic, P; Moortgat, F; Nardulli, A; Nessi-Tedaldi, F; Pape, L; Pauss, F; Punz, T; Rizzi, A; Ronga, F J; Sala, L; Sanchez, A K; Sawley, M C; Sordini, V; Stieger, B; Tauscher, L; Thea, A; Theofilatos, K; Treille, D; Trüb, P; Weber, M; Wehrli, L; Weng, J; Zelepoukine, S; Amsler, C; Chiochia, V; De Visscher, S; Regenfus, C; Robmann, P; Rommerskirchen, T; Schmidt, A; Tsirigkas, D; Wilke, L; Chang, Y H; Chen, E A; Chen, W T; Go, A; Kuo, C M; Li, S W; Lin, W; Bartalini, P; Chang, P; Chao, Y; Chen, K F; Hou, W S; Hsiung, Y; Lei, Y J; Lin, S W; Lu, R S; Schümann, J; Shiu, J G; Tzeng, Y M; Ueno, K; Velikzhanin, Y; Wang, C C; Wang, M; Adiguzel, A; Ayhan, A; Azman Gokce, A; Bakirci, M N; Cerci, S; Dumanoglu, I; Eskut, E; Girgis, S; Gurpinar, E; Hos, I; Karaman, T; Karaman, T; Kayis Topaksu, A; Kurt, P; Önengüt, G; Önengüt Gökbulut, G; Ozdemir, K; Ozturk, S; Polatöz, A; Sogut, K; Tali, B; Topakli, H; Uzun, D; Vergili, L N; Vergili, M; Akin, I V; Aliev, T; Bilmis, S; Deniz, M; Gamsizkan, H; Guler, A M; Öcalan, K; Serin, M; Sever, R; Surat, U E; Zeyrek, M; Deliomeroglu, M; Demir, D; Gülmez, E; Halu, A; Isildak, B; Kaya, M; Kaya, O; Ozkorucuklu, S; Sonmez, N; Levchuk, L; Lukyanenko, S; Soroka, D; Zub, S; Bostock, F; Brooke, J J; Cheng, T L; Cussans, D; Frazier, R; Goldstein, J; Grant, N; Hansen, M; Heath, G P; Heath, H F; Hill, C; Huckvale, B; Jackson, J; Mackay, C K; Metson, S; Newbold, D M; Nirunpong, K; Smith, V J; Velthuis, J; Walton, R; Bell, K W; Brew, C; Brown, R M; Camanzi, B; Cockerill, D J A; Coughlan, J A; Geddes, N I; Harder, K; Harper, S; Kennedy, B W; Murray, P; Shepherd-Themistocleous, C H; Tomalin, I R; Williams, J H; Womersley, W J; Worm, S D; Bainbridge, R; Ball, G; Ballin, J; Beuselinck, R; Buchmuller, O; Colling, D; Cripps, N; Davies, G; Della Negra, M; Foudas, C; Fulcher, J; Futyan, D; Hall, G; Hays, J; Iles, G; Karapostoli, G; MacEvoy, B C; Magnan, A M; Marrouche, J; Nash, J; Nikitenko, A; Papageorgiou, A; Pesaresi, M; Petridis, K; Pioppi, M; Raymond, D M; Rompotis, N; Rose, A; Ryan, M J; Seez, C; Sharp, P; Sidiropoulos, G; Stettler, M; Stoye, M; Takahashi, M; Tapper, A; Timlin, C; Tourneur, S; Vazquez Acosta, M; Virdee, T; Wakefield, S; Wardrope, D; Whyntie, T; Wingham, M; Cole, J E; Goitom, I; Hobson, P R; Khan, A; Kyberd, P; Leslie, D; Munro, C; Reid, I D; Siamitros, C; Taylor, R; Teodorescu, L; Yaselli, I; Bose, T; Carleton, M; Hazen, E; Heering, A H; Heister, A; John, J St; Lawson, P; Lazic, D; Osborne, D; Rohlf, J; Sulak, L; Wu, S; Andrea, J; Avetisyan, A; Bhattacharya, S; Chou, J P; Cutts, D; Esen, S; Kukartsev, G; Landsberg, G; Narain, M; Nguyen, D; Speer, T; Tsang, K V; Breedon, R; Calderon De La Barca Sanchez, M; Case, M; Cebra, D; Chertok, M; Conway, J; Cox, P T; Dolen, J; Erbacher, R; Friis, E; Ko, W; Kopecky, A; Lander, R; Lister, A; Liu, H; Maruyama, S; Miceli, T; Nikolic, M; Pellett, D; Robles, J; Searle, M; Smith, J; Squires, M; Stilley, J; Tripathi, M; Vasquez Sierra, R; Veelken, C; Andreev, V; Arisaka, K; Cline, D; Cousins, R; Erhan, S; Hauser, J; Ignatenko, M; Jarvis, C; Mumford, J; Plager, C; Rakness, G; Schlein, P; Tucker, J; Valuev, V; Wallny, R; Yang, X; Babb, J; Bose, M; Chandra, A; Clare, R; Ellison, J A; Gary, J W; Hanson, G; Jeng, G Y; Kao, S C; Liu, F; Liu, H; Luthra, A; Nguyen, H; Pasztor, G; Satpathy, A; Shen, B C; Stringer, R; Sturdy, J; Sytnik, V; Wilken, R; Wimpenny, S; Branson, J G; Dusinberre, E; Evans, D; Golf, F; Kelley, R; Lebourgeois, M; Letts, J; Lipeles, E; Mangano, B; Muelmenstaedt, J; Norman, M; Padhi, S; Petrucci, A; Pi, H; Pieri, M; Ranieri, R; Sani, M; Sharma, V; Simon, S; Würthwein, F; Yagil, A; Campagnari, C; D'Alfonso, M; Danielson, T; Garberson, J; Incandela, J; Justus, C; Kalavase, P; Koay, S A; Kovalskyi, D; Krutelyov, V; Lamb, J; Lowette, S; Pavlunin, V; Rebassoo, F; Ribnik, J; Richman, J; Rossin, R; Stuart, D; To, W; Vlimant, J R; Witherell, M; Apresyan, A; Bornheim, A; Bunn, J; Chiorboli, M; Gataullin, M; Kcira, D; Litvine, V; Ma, Y; Newman, H B; Rogan, C; Timciuc, V; Veverka, J; Wilkinson, R; Yang, Y; Zhang, L; Zhu, K; Zhu, R Y; Akgun, B; Carroll, R; Ferguson, T; Jang, D W; Jun, S Y; Paulini, M; Russ, J; Terentyev, N; Vogel, H; Vorobiev, I; Cumalat, J P; Dinardo, M E; Drell, B R; Ford, W T; Heyburn, B; Luiggi Lopez, E; Nauenberg, U; Stenson, K; Ulmer, K; Wagner, S R; Zang, S L; Agostino, L; Alexander, J; Blekman, F; Cassel, D; Chatterjee, A; Das, S; Gibbons, L K; Heltsley, B; Hopkins, W; Khukhunaishvili, A; Kreis, B; Kuznetsov, V; Patterson, J R; Puigh, D; Ryd, A; Shi, X; Stroiney, S; Sun, W; Teo, W D; Thom, J; Vaughan, J; Weng, Y; Wittich, P; Beetz, C P; Cirino, G; Sanzeni, C; Winn, D; Abdullin, S; Afaq, M A; Albrow, M; Ananthan, B; Apollinari, G; Atac, M; Badgett, W; Bagby, L; Bakken, J A; Baldin, B; Banerjee, S; Banicz, K; Bauerdick, L A T; Beretvas, A; Berryhill, J; Bhat, P C; Biery, K; Binkley, M; Bloch, I; Borcherding, F; Brett, A M; Burkett, K; Butler, J N; Chetluru, V; Cheung, H W K; Chlebana, F; Churin, I; Cihangir, S; Crawford, M; Dagenhart, W; Demarteau, M; Derylo, G; Dykstra, D; Eartly, D P; Elias, J E; Elvira, V D; Evans, D; Feng, L; Fischler, M; Fisk, I; Foulkes, S; Freeman, J; Gartung, P; Gottschalk, E; Grassi, T; Green, D; Guo, Y; Gutsche, O; Hahn, A; Hanlon, J; Harris, R M; Holzman, B; Howell, J; Hufnagel, D; James, E; Jensen, H; Johnson, M; Jones, C D; Joshi, U; Juska, E; Kaiser, J; Klima, B; Kossiakov, S; Kousouris, K; Kwan, S; Lei, C M; Limon, P; Lopez Perez, J A; Los, S; Lueking, L; Lukhanin, G; Lusin, S; Lykken, J; Maeshima, K; Marraffino, J M; Mason, D; McBride, P; Miao, T; Mishra, K; Moccia, S; Mommsen, R; Mrenna, S; Muhammad, A S; Newman-Holmes, C; Noeding, C; O'Dell, V; Prokofyev, O; Rivera, R; Rivetta, C H; Ronzhin, A; Rossman, P; Ryu, S; Sekhri, V; Sexton-Kennedy, E; Sfiligoi, I; Sharma, S; Shaw, T M; Shpakov, D; Skup, E; Smith, R P; Soha, A; Spalding, W J; Spiegel, L; Suzuki, I; Tan, P; Tanenbaum, W; Tkaczyk, S; Trentadue, R; Uplegger, L; Vaandering, E W; Vidal, R; Whitmore, J; Wicklund, E; Wu, W; Yarba, J; Yumiceva, F; Yun, J C; Acosta, D; Avery, P; Barashko, V; Bourilkov, D; Chen, M; Di Giovanni, G P; Dobur, D; Drozdetskiy, A; Field, R D; Fu, Y; Furic, I K; Gartner, J; Holmes, D; Kim, B; Klimenko, S; Konigsberg, J; Korytov, A; Kotov, K; Kropivnitskaya, A; Kypreos, T; Madorsky, A; Matchev, K; Mitselmakher, G; Pakhotin, Y; Piedra Gomez, J; Prescott, C; Rapsevicius, V; Remington, R; Schmitt, M; Scurlock, B; Wang, D; Yelton, J; Ceron, C; Gaultney, V; Kramer, L; Lebolo, L M; Linn, S; Markowitz, P; Martinez, G; Rodriguez, J L; Adams, T; Askew, A; Baer, H; Bertoldi, M; Chen, J; Dharmaratna, W G D; Gleyzer, S V; Haas, J; Hagopian, S; Hagopian, V; Jenkins, M; Johnson, K F; Prettner, E; Prosper, H; Sekmen, S; Baarmand, M M; Guragain, S; Hohlmann, M; Kalakhety, H; Mermerkaya, H; Ralich, R; Vodopiyanov, I; Abelev, B; Adams, M R; Anghel, I M; Apanasevich, L; Bazterra, V E; Betts, R R; Callner, J; Castro, M A; Cavanaugh, R; Dragoiu, C; Garcia-Solis, E J; Gerber, C E; Hofman, D J; Khalatian, S; Mironov, C; Shabalina, E; Smoron, A; Varelas, N; Akgun, U; Albayrak, E A; Ayan, A S; Bilki, B; Briggs, R; Cankocak, K; Chung, K; Clarida, W; Debbins, P; Duru, F; Ingram, F D; Lae, C K; McCliment, E; Merlo, J P; Mestvirishvili, A; Miller, M J; Moeller, A; Nachtman, J; Newsom, C R; Norbeck, E; Olson, J; Onel, Y; Ozok, F; Parsons, J; Schmidt, I; Sen, S; Wetzel, J; Yetkin, T; Yi, K; Barnett, B A; Blumenfeld, B; Bonato, A; Chien, C Y; Fehling, D; Giurgiu, G; Gritsan, A V; Guo, Z J; Maksimovic, P; Rappoccio, S; Swartz, M; Tran, N V; Zhang, Y; Baringer, P; Bean, A; Grachov, O; Murray, M; Radicci, V; Sanders, S; Wood, J S; Zhukova, V; Bandurin, D; Bolton, T; Kaadze, K; Liu, A; Maravin, Y; Onoprienko, D; Svintradze, I; Wan, Z; Gronberg, J; Hollar, J; Lange, D; Wright, D; Baden, D; Bard, R; Boutemeur, M; Eno, S C; Ferencek, D; Hadley, N J; Kellogg, R G; Kirn, M; Kunori, S; Rossato, K; Rumerio, P; Santanastasio, F; Skuja, A; Temple, J; Tonjes, M B; Tonwar, S C; Toole, T; Twedt, E; Alver, B; Bauer, G; Bendavid, J; Busza, W; Butz, E; Cali, I A; Chan, M; D'Enterria, D; Everaerts, P; Gomez Ceballos, G; Hahn, K A; Harris, P; Jaditz, S; Kim, Y; Klute, M; Lee, Y J; Li, W; Loizides, C; Ma, T; Miller, M; Nahn, S; Paus, C; Roland, C; Roland, G; Rudolph, M; Stephans, G; Sumorok, K; Sung, K; Vaurynovich, S; Wenger, E A; Wyslouch, B; Xie, S; Yilmaz, Y; Yoon, A S; Bailleux, D; Cooper, S I; Cushman, P; Dahmes, B; De Benedetti, A; Dolgopolov, A; Dudero, P R; Egeland, R; Franzoni, G; Haupt, J; Inyakin, A; Klapoetke, K; Kubota, Y; Mans, J; Mirman, N; Petyt, D; Rekovic, V; Rusack, R; Schroeder, M; Singovsky, A; Zhang, J; Cremaldi, L M; Godang, R; Kroeger, R; Perera, L; Rahmat, R; Sanders, D A; Sonnek, P; Summers, D; Bloom, K; Bockelman, B; Bose, S; Butt, J; Claes, D R; Dominguez, A; Eads, M; Keller, J; Kelly, T; Kravchenko, I; Lazo-Flores, J; Lundstedt, C; Malbouisson, H; Malik, S; Snow, G R; Baur, U; Iashvili, I; Kharchilava, A; Kumar, A; Smith, K; Strang, M; Alverson, G; Barberis, E; Boeriu, O; Eulisse, G; Govi, G; McCauley, T; Musienko, Y; Muzaffar, S; Osborne, I; Paul, T; Reucroft, S; Swain, J; Taylor, L; Tuura, L; Anastassov, A; Gobbi, B; Kubik, A; Ofierzynski, R A; Pozdnyakov, A; Schmitt, M; Stoynev, S; Velasco, M; Won, S; Antonelli, L; Berry, D; Hildreth, M; Jessop, C; Karmgard, D J; Kolberg, T; Lannon, K; Lynch, S; Marinelli, N; Morse, D M; Ruchti, R; Slaunwhite, J; Warchol, J; Wayne, M; Bylsma, B; Durkin, L S; Gilmore, J; Gu, J; Killewald, P; Ling, T Y; Williams, G; Adam, N; Berry, E; Elmer, P; Garmash, A; Gerbaudo, D; Halyo, V; Hunt, A; Jones, J; Laird, E; Marlow, D; Medvedeva, T; Mooney, M; Olsen, J; Piroué, P; Stickland, D; Tully, C; Werner, J S; Wildish, T; Xie, Z; Zuranski, A; Acosta, J G; Bonnett Del Alamo, M; Huang, X T; Lopez, A; Mendez, H; Oliveros, S; Ramirez Vargas, J E; Santacruz, N; Zatzerklyany, A; Alagoz, E; Antillon, E; Barnes, V E; Bolla, G; Bortoletto, D; Everett, A; Garfinkel, A F; Gecse, Z; Gutay, L; Ippolito, N; Jones, M; Koybasi, O; Laasanen, A T; Leonardo, N; Liu, C; Maroussov, V; Merkel, P; Miller, D H; Neumeister, N; Sedov, A; Shipsey, I; Yoo, H D; Zheng, Y; Jindal, P; Parashar, N; Cuplov, V; Ecklund, K M; Geurts, F J M; Liu, J H; Maronde, D; Matveev, M; Padley, B P; Redjimi, R; Roberts, J; Sabbatini, L; Tumanov, A; Betchart, B; Bodek, A; Budd, H; Chung, Y S; de Barbaro, P; Demina, R; Flacher, H; Gotra, Y; Harel, A; Korjenevski, S; Miner, D C; Orbaker, D; Petrillo, G; Vishnevskiy, D; Zielinski, M; Bhatti, A; Demortier, L; Goulianos, K; Hatakeyama, K; Lungu, G; Mesropian, C; Yan, M; Atramentov, O; Bartz, E; Gershtein, Y; Halkiadakis, E; Hits, D; Lath, A; Rose, K; Schnetzer, S; Somalwar, S; Stone, R; Thomas, S; Watts, T L; Cerizza, G; Hollingsworth, M; Spanier, S; Yang, Z C; York, A; Asaadi, J; Aurisano, A; Eusebi, R; Golyash, A; Gurrola, A; Kamon, T; Nguyen, C N; Pivarski, J; Safonov, A; Sengupta, S; Toback, D; Weinberger, M; Akchurin, N; Berntzon, L; Gumus, K; Jeong, C; Kim, H; Lee, S W; Popescu, S; Roh, Y; Sill, A; Volobouev, I; Washington, E; Wigmans, R; Yazgan, E; Engh, D; Florez, C; Johns, W; Pathak, S; Sheldon, P; Andelin, D; Arenton, M W; Balazs, M; Boutle, S; Buehler, M; Conetti, S; Cox, B; Hirosky, R; Ledovskoy, A; Neu, C; Phillips II, D; Ronquest, M; Yohay, R; Gollapinni, S; Gunthoti, K; Harr, R; Karchin, P E; Mattson, M; Sakharov, A; Anderson, M; Bachtis, M; Bellinger, J N; Carlsmith, D; Crotty, I; Dasu, S; Dutta, S; Efron, J; Feyzi, F; Flood, K; Gray, L; Grogg, K S; Grothe, M; Hall-Wilton, R; Jaworski, M; Klabbers, P; Klukas, J; Lanaro, A; Lazaridis, C; Leonard, J; Loveless, R; Magrans de Abril, M; Mohapatra, A; Ott, G; Polese, G; Reeder, D; Savin, A; Smith, W H; Sourkov, A; Swanson, J; Weinberg, M; Wenman, D; Wensveen, M; White, A

    2010-01-01

    In October and November 2008, the CMS collaboration conducted a programme of cosmic ray data taking, which has recorded about 270 million events. The Resistive Plate Chamber system, which is part of the CMS muon detection system, was successfully operated in the full barrel. More than 98% of the channels were operational during the exercise with typical detection efficiency of 90%. In this paper, the performance of the detector during these dedicated runs is reported.

  2. Right and left support feet of the Central Barrel Yoke of the CMS Detector

    CERN Multimedia

    Franz Leher, DWE

    2000-01-01

    Fully loaded the Central Barrel will weigh 3000 tonnes. Those feet have tosupport this weight. Therefore they are made of 120 mm thick steel plates.To guarantee a maximum coverage for the muon detctor they will house a muon detector just benaeth the top plate. Weight of 1 foot is 35 tonnes.Its height is 3.5 m and it is 2.5 m large

  3. Functions of phenylalanine residues within the beta-barrel stem of the anthrax toxin pore.

    Directory of Open Access Journals (Sweden)

    Jie Wang

    Full Text Available BACKGROUND: A key step of anthrax toxin action involves the formation of a protein-translocating pore within the endosomal membrane by the Protective Antigen (PA moiety. Formation of this transmembrane pore by PA involves interaction of the seven 2beta2-2beta3 loops of the heptameric precursor to generate a 14-strand transmembrane beta barrel. METHODOLOGY/PRINCIPAL FINDINGS: We examined the effects on pore formation, protein translocation, and cytotoxicity, of mutating two phenylalanines, F313 and F314, that lie at the tip the beta barrel, and a third one, F324, that lies part way up the barrel. CONCLUSIONS/SIGNIFICANCE: Our results show that the function of these phenylalanine residues is to mediate membrane insertion and formation of stable transmembrane channels. Unlike F427, a key luminal residue in the cap of the pore, F313, F314, and F324 do not directly affect protein translocation through the pore. Our findings add to our knowledge of structure-function relationships of a key virulence factor of the anthrax bacillus.

  4. Destiny of a drop on a fiber: from barrel to clamshell and back

    Science.gov (United States)

    Eral, Burak; de Ruiter, J.; de Ruiter, R.; Oh, J. M.; Semprebon, C.; Brinkman, M.; Mugele, F.

    2011-11-01

    Drops on cylindrical fibers are a familiar sight, for instance in the form of dew drops on spider webs. They can exist in two competing morphologies, a cylindrically symmetric barrel state completely engulfing the fiber and an asymmetric clamshell state, in which the drop sits on the side of the fiber. Despite their omnipresence and their practical relevance the physical mechanisms governing the stability of the two morphologies remained elusive. Using electrowetting-functionalized fibers we determined of the stability limits of both morphologies as a function of the two relevant control parameters, the contact angle and the liquid volume. While clamshells are found to prevail for large contact angles and small volumes, and barrels prevail for small angles and large volumes, there is also a wide range of intermediate parameter values, for which both morphologies are mechanically stable. Mapping out the energy landscape of the system by numerical minimization of the free energy we find that the barrel state is easily deformed by non-axisymmetric perturbations. From a general perspective, the demonstration of electrowetting-based reversible switching of liquid morphologies on fibers opens up opportunities for designing functional textiles and porous materials. We thank the Chemical Sciences division of the Netherlands Organization for Scientific Research (NWO-CW) for financial support.

  5. Folding of β-barrel membrane proteins in lipid bilayers - Unassisted and assisted folding and insertion.

    Science.gov (United States)

    Kleinschmidt, Jörg H

    2015-09-01

    In cells, β-barrel membrane proteins are transported in unfolded form to an outer membrane into which they fold and insert. Model systems have been established to investigate the mechanisms of insertion and folding of these versatile proteins into detergent micelles, lipid bilayers and even synthetic amphipathic polymers. In these experiments, insertion into lipid membranes is initiated from unfolded forms that do not display residual β-sheet secondary structure. These studies therefore have allowed the investigation of membrane protein folding and insertion in great detail. Folding of β-barrel membrane proteins into lipid bilayers has been monitored from unfolded forms by dilution of chaotropic denaturants that keep the protein unfolded as well as from unfolded forms present in complexes with molecular chaperones from cells. This review is aimed to provide an overview of the principles and mechanisms observed for the folding of β-barrel transmembrane proteins into lipid bilayers, the importance of lipid-protein interactions and the function of molecular chaperones and folding assistants. This article is part of a Special Issue entitled: Lipid-protein interactions.

  6. Evaluation of using short barrel DHS in treatment of intertrochanteric fractures

    Directory of Open Access Journals (Sweden)

    Tahmasbi M

    2001-10-01

    Full Text Available Cut out or extrusion of the lag screw from the superior aspect of head and neck of the femur is one of the most common and devastating complications of the surgery of the intertrochanteric fractures with DHS. The exact cause of this complications is unknown, but it seems to be related to osteopenia, inappropriate position of lag screw inside head of the femur and inability of DHS to slide inside the barrel, which is the most ignored risk factor. We used short barrel Dynamic Hip Screw (DHS for fixation of the intertrochanteric fractures in Dimon and Hughston procedure in 16 patients with unstable fracture, from may to August 2000. The only patient suffered from cut out is the one with static position of DHS in the center of the head. The other complications were delayed union in one, disingagement of the lag screw and side plate despite using compression screw, and one case of significant limb length discrepancy 6 months after surgery, mild limbing was the rule and the average of harris scores was 76. We think that, it is possible to reduce the rate of cut out with choosing short barrel DHS instead of the standard one, while using short length lag screw.

  7. CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex

    Directory of Open Access Journals (Sweden)

    Annabella Pignataro

    2015-01-01

    Full Text Available Experience modifies synaptic connectivity through processes that involve dendritic spine rearrangements in neuronal circuits. Although cAMP response element binding protein (CREB has a key function in spines changes, its role in activity-dependent rearrangements in brain regions of rodents interacting with the surrounding environment has received little attention so far. Here we studied the effects of vibrissae trimming, a widely used model of sensory deprivation-induced cortical plasticity, on processes associated with dendritic spine rearrangements in the barrel cortex of a transgenic mouse model of CREB downregulation (mCREB mice. We found that sensory deprivation through prolonged whisker trimming leads to an increased number of thin spines in the layer V of related barrel cortex (Contra in wild type but not mCREB mice. In the barrel field controlling spared whiskers (Ipsi, the same trimming protocol results in a CREB-dependent enlargement of dendritic spines. Last, we demonstrated that CREB regulates structural rearrangements of synapses that associate with dynamic changes of dendritic spines. Our findings suggest that CREB plays a key role in dendritic spine dynamics and synaptic circuits rearrangements that account for new brain connectivity in response to changes in the environment.

  8. Upgrade of the CMS muon trigger system in the barrel region

    CERN Document Server

    Rabady, Dinyar Sebastian

    2016-01-01

    To maintain the excellent performance shown during the LHCs Run-1 the Level-1 Trigger of the Compact Muon Solenoid experiment underwent a significant upgrade. One part of this upgrade is the re-organization of the muon trigger path from a subsystem-centric view in which hits in the drift tubes (DT), the cathode strip chambers (CSC), and the resistive plate chambers (RPC) were treated separately in dedicated track-finding systems to one in which complementary detector systems for a given region (barrel, overlap, and endcap) are merged at the track-finding level. This fundamental restructuring of the muon trigger system required the development of a system to receive track candidates from the track-finding layer, remove potential duplicate tracks, and forward the best candidates to the global decision layer.An overview will be given of the new track-finder system for the barrel region, the Barrel Muon Track Finder (BMTF) as well as the cancel-out and sorting layer, the upgraded Global Muon Trigger ($\\mu$GMT). B...

  9. Improving the Resistance of a Eukaryotic β-Barrel Protein to Thermal and Chemical Perturbation

    Science.gov (United States)

    Gessmann, Dennis; Mager, Frauke; Naveed, Hammad; Arnold, Thomas; Weirich, Sara; Linke, Dirk; Liang, Jie; Nussberger, Stephan

    2013-01-01

    Beta-barrel membrane proteins have regular structures with extensive hydrogen bonding networks between their transmembrane (TM) β-strands, which stabilize their protein fold. Nevertheless, weakly stable TM regions exist, which are important for the protein function and interaction with other proteins. Here, we report on the apparent stability of human Tom40A, a member of the ‘mitochondrial porin family’ and main constituent of the mitochondrial protein-conducting channel TOM. Using a physical interaction model TmSIP for β-barrel membrane proteins, we have identified three β-strands unfavorable in the TM domain of the protein. Substitution of key residues inside these strands with hydrophobic amino acids results in a decreased sensitivity of the protein to chemical and/or thermal denaturation. The apparent melting temperature observed when denatured at a rate of one degree per minute, is shifted from 73 to 84 °C. Moreover, the sensitivity of the protein to denaturant agents is significantly lowered. Further, we find a reduced tendency for the mutated protein to form dimers. We propose that the identified weakly stable β-strands 1, 2 and 9 of human Tom40A play an important role in quaternary protein-protein interactions within the mammalian TOM machinery. Our results show that the use of empirical energy functions to model the apparent stability of β-barrel membrane proteins may be a useful tool in the field of nanopore bioengineering. PMID:21835183

  10. Improving the resistance of a eukaryotic β-barrel protein to thermal and chemical perturbations.

    Science.gov (United States)

    Gessmann, Dennis; Mager, Frauke; Naveed, Hammad; Arnold, Thomas; Weirich, Sara; Linke, Dirk; Liang, Jie; Nussberger, Stephan

    2011-10-14

    β-Barrel membrane proteins have regular structures with extensive hydrogen-bond networks between their transmembrane (TM) β-strands, which stabilize their protein fold. Nevertheless, weakly stable TM regions, which are important for the protein function and interaction with other proteins, exist. Here, we report on the apparent stability of human Tom40A, a member of the "mitochondrial porin family" and main constituent of the mitochondrial protein-conducting channel TOM (translocase of the outer membrane). Using a physical interaction model, TmSIP, for β-barrel membrane proteins, we have identified three unfavorable β-strands in the TM domain of the protein. Substitution of key residues inside these strands with hydrophobic amino acids results in a decreased sensitivity of the protein to chemical and/or thermal denaturation. The apparent melting temperature observed when denatured at a rate of 1 °C per minute is shifted from 73 to 84 °C. Moreover, the sensitivity of the protein to denaturant agents is significantly lowered. Further, we find a reduced tendency for the mutated protein to form dimers. We propose that the identified weakly stable β-strands 1, 2 and 9 of human Tom40A play an important role in quaternary protein-protein interactions within the mammalian TOM machinery. Our results show that the use of empirical energy functions to model the apparent stability of β-barrel membrane proteins may be a useful tool in the field of nanopore bioengineering.

  11. A Novel Bonding Method of Pure Aluminum and SUS304 Stainless Steel Using Barrel Nitriding

    Science.gov (United States)

    Kong, Jung Hyun; Okumiya, Masahiro; Tsunekawa, Yoshiki; Yun, Ky Youl; Kim, Sang Gweon; Yoshida, Masashi

    2014-09-01

    A great deal of research is being carried out on welding or bonding methods between iron and aluminum. However, it is not so easy to make Fe-Al bonding materials with both high strength and light weight. Recently, a new nitriding process has been proposed to produce aluminum nitride on an aluminum surface using a barrel. This study proposes a new concept in the production of a multilayer which has an AlN and Fe-Al intermetallic compound layer between the aluminum and steel using a barrel nitriding process. The bonding process was carried out from 893 K to 913 K (620 °C to 640 °C) for 18, 25.2, and 36 ks with Al2O3 powder and Al-Mg alloy powder. After the process, an aluminum nitride (AlN) layer and a Fe-Al intermetallic compound (Fe2Al5.4) layer were formed at the interface between the pure aluminum and SUS304 austenitic stainless steel. The thicknesses of the AlN layer and the intermetallic compound layer increased with increasing treatment temperature and time. The maximum hardnesses of the AlN layer and Fe2Al5.4 layers were found to be 377HV and 910HV, respectively, after barrel nitriding at 893 K (620 °C) for 18 ks.

  12. Resource Review Board Celebrates the Magnet and Liquid Argon Barrel Tests in Hall 180

    CERN Multimedia

    Jenni, P.

    2004-01-01

    Address by the Director-General, R. Aymar, in front of the barrel cryostat. On 25th October 2004 many RRB delegates and guests, ATLAS National Contact Physicists, and colleagues from far and from CERN working on the Liquid Argon calorimeter and the magnet system were gathering in Hall 180 to celebrate the major milestones reached during the past months in this hall: the successful cold tests of the first barrel toroid coil, of the solenoid, and of the barrel Liquid Argon calorimeter. About 250 people spent a relaxing evening after the speeches by the Director-General R. Aymar and by the spokesperson who gave the following address: 'It is a great pleasure for me to welcome you all here in Hall 180 in the name of the ATLAS Collaboration! With a few words I would like to recall why we are actually here today to share, what I hope, is a relaxed and joyful moment. To concentrate it all in one sentence I could say: To thank cordially all the main actors for the enormous work accomplished here over many years,...

  13. Plasticity-Related Gene 1 Affects Mouse Barrel Cortex Function via Strengthening of Glutamatergic Thalamocortical Transmission.

    Science.gov (United States)

    Unichenko, Petr; Kirischuk, Sergei; Yang, Jenq-Wei; Baumgart, Jan; Roskoden, Thomas; Schneider, Patrick; Sommer, Angela; Horta, Guilherme; Radyushkin, Konstantin; Nitsch, Robert; Vogt, Johannes; Luhmann, Heiko J

    2016-07-01

    Plasticity-related gene-1 (PRG-1) is a brain-specific protein that modulates glutamatergic synaptic transmission. Here we investigated the functional role of PRG-1 in adolescent and adult mouse barrel cortex both in vitro and in vivo. Compared with wild-type (WT) animals, PRG-1-deficient (KO) mice showed specific behavioral deficits in tests assessing sensorimotor integration and whisker-based sensory discrimination as shown in the beam balance/walking test and sandpaper tactile discrimination test, respectively. At P25-31, spontaneous network activity in the barrel cortex in vivo was higher in KO mice compared with WT littermates, but not at P16-19. At P16-19, sensory evoked cortical responses in vivo elicited by single whisker stimulation were comparable in KO and WT mice. In contrast, at P25-31 evoked responses were smaller in amplitude and longer in duration in WT animals, whereas KO mice revealed no such developmental changes. In thalamocortical slices from KO mice, spontaneous activity was increased already at P16-19, and glutamatergic thalamocortical inputs to Layer 4 spiny stellate neurons were potentiated. We conclude that genetic ablation of PRG-1 modulates already at P16-19 spontaneous and evoked excitability of the barrel cortex, including enhancement of thalamocortical glutamatergic inputs to Layer 4, which distorts sensory processing in adulthood.

  14. Surface and near surface defect detection in thick copper EB-welds using eddy current testing

    Energy Technology Data Exchange (ETDEWEB)

    Pitkaenen, J. (Posiva Oy, Eurajoki (Finland)); Lipponen, A. (VTT Technical Research Centre of Finland, Espoo (Finland))

    2010-05-15

    The surface inspection of thick copper electron beam (EB) welds plays an important role in the acceptance of nuclear fuel disposal. The main reasons to inspect these components are related to potential manufacturing and handling defects. In this work the data acquisition software, visualising tools for eddy current (EC) measurements and eddy current sensors were developed for detection of unwanted defects. The eddy current equipment was manufactured by IZFP and the visualising software in active co-operation with Posiva and IZFP for the inspections. The inspection procedure was produced during the development of the inspection techniques. The inspection method development aims to qualify the method for surface and near surface defect detection and sizing according to ENIQ. The study includes technical justification to be carried out, and compilation of a defect catalogue and experience from measurements within the Posiva's research on issues related to manufacturing. The depth of penetration in copper components in eddy current testing is rather small. To detect surface breaking defects the eddy current inspection is a good solution. A simple approach was adopted using two techniques: higher frequency was used to detect surface defects and to determine the dimensions of the defects except depth, lower frequency was used to detect defects having a ligament and for sizing of deeper surface breaking defects. The higher frequency was 30 kHz and the lower frequency was 200 Hz. The higher frequency probes were absolute bobbing coils and lower frequency probes combined transmitter - several receiver coils. To evaluate both methods, calibration blocks were manufactured by FNS for weld inspections. These calibration specimens mainly consisted of electron discharge machined notches and holes of varying shapes, lengths and diameters in the range of 1 mm to 20 mm of depth. Also one copper lid specimen with 152 defects was manufactured and used for evaluation of weld

  15. De novo backbone and sequence design of an idealized alpha/beta-barrel protein: Evidence of stable tertiary structure

    OpenAIRE

    Offredi, Fabrice; Dubail, Fabien; Kischel, Philippe; Sarinski, K.; Stern, A S; Van de Weerdt, Cécile; Hoch, J. C.; Prosperi, Christelle; François, Jean-Marie; Mayo, S. L.; Martial, Joseph

    2003-01-01

    We have designed, synthesized, and characterized a 216 amino acid residue sequence encoding a putative idealized alpha/beta-barrel protein. The design was elaborated in two steps. First, the idealized backbone was defined with geometric parameters representing our target fold: a central eight parallel-stranded beta-sheet surrounded by eight parallel alpha-helices, connected together with short structural turns on both sides of the barrel. An automated sequence selection algorithm, based on th...

  16. Divergent evolution of a beta/alpha-barrel subclass: detection of numerous phosphate-binding sites by motif search.

    OpenAIRE

    Bork, P.; Gellerich, J.; Groth, H.; Hooft, R.; Martin, F.

    1995-01-01

    Study of the most conserved region in many beta/alpha-barrels, the phosphate-binding site, revealed a sequence motif in a few beta/alpha-barrels with known tertiary structure, namely glycolate oxidase (GOX), cytochrome b2 (Cyb2), tryptophan synthase alpha subunit (TrpA), and the indoleglycerolphosphate synthase (TrpC). Database searches identified this motif in numerous other enzyme families: (1) IMP dehydrogenase (IMPDH) and GMP reductase (GuaC); (2) phosphoribosylformimino-5-aminoimidazol c...

  17. System Research Of Multi-Barrel Machine Guns Installed On Board Of The Helicopter Of Mi-17 Type

    Directory of Open Access Journals (Sweden)

    Bęczkowski Grzegorz

    2015-08-01

    Full Text Available This article presents tests of a multi-barreled machine gun system built on board of a helicopter. The described weapon system consists of three 7.62 mm M-134G multi-barreled machine guns built on the designed frames of shooting positions located in the escape hatch window, the side doors and the rear doors of the transport cabin of the Mi-17-1V helicopter.

  18. Shifts in developmental timing, and not increased levels of experience-dependent neuronal activity, promote barrel expansion in the primary somatosensory cortex of rats enucleated at birth.

    Directory of Open Access Journals (Sweden)

    Ingrid Fetter-Pruneda

    Full Text Available Birth-enucleated rodents display enlarged representations of whiskers (i.e., barrels of the posteromedial subfield in the primary somatosensory cortex. Although the historical view maintains that barrel expansion is due to incremental increases in neuronal activity along the trigeminal pathway during postnatal development, recent evidence obtained in experimental models of intramodal plasticity challenges this view. Here, we re-evaluate the role of experience-dependent neuronal activity on barrel expansion in birth-enucleated rats by combining various anatomical methods and sensory deprivation paradigms. We show that barrels in birth-enucleated rats were already enlarged by the end of the first week of life and had levels of metabolic activity comparable to those in control rats at different ages. Dewhiskering after the postnatal period of barrel formation did not prevent barrel expansion in adult, birth-enucleated rats. Further, dark rearing and enucleation after barrel formation did not lead to expanded barrels in adult brains. Because incremental increases of somatosensory experience did not promote barrel expansion in birth-enucleated rats, we explored whether shifts of the developmental timing could better explain barrel expansion during the first week of life. Accordingly, birth-enucleated rats show earlier formation of barrels, accelerated growth of somatosensory thalamocortical afferents, and an earlier H4 deacetylation. Interestingly, when H4 deacetylation was prevented with a histone deacetylases inhibitor (valproic acid, barrel specification timing returned to normal and barrel expansion did not occur. Thus, we provide evidence supporting that shifts in developmental timing modulated through epigenetic mechanisms, and not increased levels of experience dependent neuronal activity, promote barrel expansion in the primary somatosensory cortex of rats enucleated at birth.

  19. Volatile compounds in a spanish red wine aged in barrels made of Spanish, French, and American oak wood.

    Science.gov (United States)

    De Simón, Brígida Fernández; Cadahía, Estrella; Jalocha, Jerzy

    2003-12-17

    A red Rioja wine was aged in barrels made of Spanish oak wood (Quercus robur, Quercus petraea,Quercus pyrenaica, and Quercus faginea) during 21 months. The concentrations of some volatile compounds [syringaldehyde, vanillin, eugenol, maltol, guaiacol, 4-ethylphenol, cis and trans isomers of beta-methyl-gamma-octalactone, 2-furfuraldehyde, 5-methyl-2-furfuraldehyde, 5-(hydroxymethyl)-2-furfuraldehyde, and furfuryl alcohol] were studied in these wines and compared with those of the same wine aged in barrels made from French oak of Q. robur (Limousin, France) and Q. petraea (Allier, France) and American oak of Quercus alba (Missouri). Similar concentrations of these compounds were found in wines aged in Spanish and French oak wood barrels, and significantly different concentrations were found with respect to wines aged in barrels made of American oak wood, indicating a different behavior. Thus, wines with different characteristics were obtained, depending on the kind of wood. Also, the kind of wood had an important influence on sensory characteristics of wine during the aging process. Spanish oak wood from Q. robur, Q. petraea, and Q. pyrenaica can be considered to be suitable for barrel production for quality wines, because a wine aged in barrels made of these Spanish oak woods showed similar and intermediate characteristics to those of the same wine aged in French and American oak woods usually used in cooperage.

  20. A barrel-related interneuron in layer 4 of rat somatosensory cortex with a high intrabarrel connectivity.

    Science.gov (United States)

    Koelbl, Christian; Helmstaedter, Moritz; Lübke, Joachim; Feldmeyer, Dirk

    2015-03-01

    Synaptic connections between identified fast-spiking (FS), parvalbumin (PV)-positive interneurons, and excitatory spiny neurons in layer 4 (L4) of the barrel cortex were investigated using patch-clamp recordings and simultaneous biocytin fillings. Three distinct clusters of FS L4 interneurons were identified based on their axonal morphology relative to the barrel column suggesting that these neurons do not constitute a homogeneous interneuron population. One L4 FS interneuron type had an axonal domain strictly confined to a L4 barrel and was therefore named "barrel-confined inhibitory interneuron" (BIn). BIns established reliable inhibitory synaptic connections with L4 spiny neurons at a high connectivity rate of 67%, of which 69% were reciprocal. Unitary IPSPs at these connections had a mean amplitude of 0.9 ± 0.8 mV with little amplitude variation and weak short-term synaptic depression. We found on average 3.7 ± 1.3 putative inhibitory synaptic contacts that were not restricted to perisomatic areas. In conclusion, we characterized a novel type of barrel cortex interneuron in the major thalamo-recipient layer 4 forming dense synaptic networks with L4 spiny neurons. These networks constitute an efficient and powerful inhibitory feedback system, which may serve to rapidly reset the barrel microcircuitry following sensory activation. PMID:24076498

  1. Development and installation of an advanced beam guidance system on Viking`s 2.4 megawatt EB furnace

    Energy Technology Data Exchange (ETDEWEB)

    Motchenbacher, C.A.; Grosse, I.A. [Viking Metallurgical, Verdi, NV (United States)

    1994-12-31

    Viking Metallurgical is a manufacturer of titanium alloy and superalloy seamless ring forgings for the aerospace industry. For more than 20 years Viking has used electron beam cold hearth melting to recover titanium alloy scrap and to produce commercially pure titanium ingot for direct forging. In the 1970`s Viking pioneered electron beam cold hearth melting and in 1983 added a two-gun, 2.4 MW furnace. As part of Vikings efforts to improve process control we have commissioned and installed a new electron beam guidance system. The system is capable of generating virtually unlimited EB patterns resulting in improved melt control.

  2. Analysis of the situation of EB virus infection in patients with Sjogren′s syndrome%干燥综合征患者 EB 病毒感染分析

    Institute of Scientific and Technical Information of China (English)

    李华; 王吉波; 王丽芹

    2014-01-01

    目的:分析干燥综合征患者EB病毒感染状况,研究干燥综合征发病与EB病毒感染之间的相关性,为干燥综合征的诊断和治疗提供依据。方法选取干燥综合征患者75例、健康人员74名,取其血清进行ELISA和实时定量PCR检测,分析干燥综合征与EB病毒感染的相关性,采用SPSS13.0进行统计分析。结果 VCA‐IgM抗体阳性率患者组为18.7%、对照组为2.7%,两组比较,差异有统计学意义(P<0.05);VCA‐IgG抗体阳性率患者组为100.0%、对照组为97.3%,两组比较,差异无统计学意义;EA‐IgG抗体阳性率患者组为60.0%、对照组为5.4%,两组比较,差异有统计学意义(P<0.05),患者组EB病毒DNA拷贝数均值明显高于对照组,差异均有统计学意义( P<0.05)。结论干燥综合征的发病与EB病毒的感染相关,给干燥综合征的诊断和治疗提供指导意义。%OBJECTIVE To analyze the situation of EB virus infection in patients with Sjogren′s syndrome ,investi‐gate the relevancy between Sjogren′s syndrome and EB virus ,so as to provide some evidences for diagnosis and treatment of patients with Sjogren′s syndrome .METHODS Totally 75 cases of patients with Sjogren′s syndrome and 74 controlled cases were chosen .Blood serum was isolated ,and ELISA and RT‐PCR were used to analyze the relevancy between Sjogren′s syndrome and EB virus . SPSS13 .0 was adopted to make a statistic analysis . RESULTS The positive rate of VCA‐IgM antibody for the patients group (18 .7% ) was significantly higher than that of the control group (2 .7% ) .The comparison has statistical significance (P< 0 .05) .The positive rate of VCA‐IgG antibody for the patients group (100 .0% ) was a little higher than that of the control group (97 .3% ) , which is without statistical significance .The positive rate of EA‐IgG antibody for the patients group (60 .0% ) was significanfly

  3. EB-FRP 及 HB-FRP 加固预裂 RC梁对比试验研究%Experimental Analysis of Pre-cracked RC Beams Strengthened with EB-FRP and HB-FRP

    Institute of Scientific and Technical Information of China (English)

    管延华; 朱登元; 庄培芝; 李红超; 周志东

    2013-01-01

    On the basis of the crack characteristics of aging RC beam bridges ,the cross-section of RC simple beams with different pre-cracking levels were strengthened by the externally bonded FRP (EB-FRP)and the FRP-bolt hybrid bonding(HB-FRP)respectively to check the strengthening characteristics of HB-FRP .The flexural test with symmetrical loading on two points was conducted to study the mechanical behavior and failure mode of pre-crack beams strengthened with EB-FRP and HB-FRP .The influence of pre-cracking level on the FRP initial debonding load and FRP utilization ratio was assessed respectively .The test results show that the flexural capacity of pre-cracking beam strengthened with HB-FRP can be improved by 30% ~44% compared with the one with EB-FRP . The failure mode has been changed from FRP brittleness debonding of beam strengthened with EB-FRP to obvious ductility failure of beam strengthened with HB-FRP .Furthermore ,the crack distribution of RC beam has obvious influence on the FRP initial debonding load ,the FRP utilization ratio and the failure mode of strengthened pre-crack beams .%为验证FRP 螺栓加固新技术的合理性,结合现役钢筋混凝土桥梁带裂缝工作的特点,采用表面粘贴FRP(EB-FRP)加固技术和FRP 螺栓混合加固技术(HB-FRP),分别对不同预裂度的钢筋混凝土简支梁进行抗弯加固,通过两点对称加载抗弯试验研究加固预裂梁的受力特性和破坏模式,分析裂缝分布对加固预裂梁的剥离荷载及FRP材料利用率的影响。试验结果表明,与表面粘贴FRP加固技术相比较,采用 FRP 螺栓混合加固的预裂梁,抗弯极限承载能力提高30%~44%,加固后结构的破坏表现为明显的延性,改善了FRP脆性剥离破坏模式;另外,钢筋混凝土梁裂缝对FRP的剥离荷载、FRP材料的利用率及梁的破坏模式影响显著。

  4. +TIP EB1 downregulates paclitaxel‑induced proliferation inhibition and apoptosis in breast cancer cells through inhibition of paclitaxel binding on microtubules.

    Science.gov (United States)

    Thomas, Geethu Emily; Sreeja, Jamuna S; Gireesh, K K; Gupta, Hindol; Manna, Tapas K

    2015-01-01

    Microtubule plus‑end‑binding protein (+TIP) EB1 has been shown to be upregulated in breast cancer cells and promote breast tumor growth in vivo. However, its effect on the cellular actions of microtubule‑targeted drugs in breast cancer cells has remained poorly understood. By using cellular and biochemical assays, we demonstrate that EB1 plays a critical role in regulating the sensitivity of breast cancer cells to anti‑microtubule drug, paclitaxel (PTX). Cell viability assays revealed that EB1 expression in the breast cancer cell lines correlated with the reduction of their sensitivity to PTX. Knockdown of EB1 by enzymatically‑prepared siRNA pools (esiRNAs) increased PTX‑induced cytotoxicity and sensitized cells to PTX‑induced apoptosis in three breast cancer cell lines, MCF‑7, MDA MB‑231 and T47D. Apoptosis was associated with activation of caspase‑9 and an increase in the cleavage of poly(ADP‑ribose) polymerase (PARP). p53 and Bax were upregulated and Bcl2 was downregulated in the EB1‑depleted PTX‑treated MCF‑7 cells, indicating that the apoptosis occurs via a p53‑dependent pathway. Following its upregulation, the nuclear accumulation of p53 and its association with cellular microtubules were increased. EB1 depletion increased PTX‑induced microtubule bundling in the interphase cells and induced formation of multiple spindle foci with abnormally elongated spindles in the mitotic MCF‑7 cells, indicating that loss of EB1 promotes PTX‑induced stabilization of microtubules. EB1 inhibited PTX‑induced microtubule polymerization and diminished PTX binding to microtubules in vitro, suggesting that it modulates the binding sites of PTX at the growing microtubule ends. Results demonstrate that EB1 downregulates inhibition of PTX‑induced proliferation and apoptosis in breast cancer cells through a mechanism in which it impairs PTX‑mediated stabilization of microtubule polymerization and inhibits PTX binding on microtubules

  5. EB-welding of the copper canister for the nuclear waste disposal. Final report of the development programme 1994-1997

    Energy Technology Data Exchange (ETDEWEB)

    Aalto, H. [Outokumpu Oy Poricopper, Pori (Finland)

    1998-10-01

    During 1994-1997 Posiva Oy and Outokumpu Poricopper Oy had a joint project Development of EB-welding method for massive copper canister manufacturing. The project was part of the national technology program `Weld 2000` and it was supported financially by Technology Development Centre (TEKES). The spent fuel from Finnish nuclear reactors is planned to be encapsulated in thick-walled copper canisters and placed deep into the bedrock. The thick copper layer of the canister provides a long time corrosion resistance and prevents deposited nuclear fuel from contact with water. The quality requirements of the copper components are high because of the designed long lifetime of the canister. The EB-welding technology has proved to be applicable method for the production of the copper canisters and the EB-welding technique is needed at least when the lids of the copper canister will be closed. There are a number of parameters in EB-welding which affect weldability. However, the effect of the welding parameters and their optimization has not been extensively studied in welding of thick copper sections using conventional high vacuum EB-welding. One aim of this development work was to extensively study effect of welding parameters on weld quality. The final objective was to minimise welding defects in the main weld and optimize slope out procedure in thick copper EB-welding. Welding of 50 mm thick copper sections was optimized using vertical and horizontal EB-welding techniques. As a result two full scale copper lids were welded to a short cylinder successfully. The resulting weld quality with optimised welding parameters was reasonable good. The optimised welding parameters for horizontal and vertical beam can be applied to the longitudinal body welds of the canister. The optimal slope out procedure for the lid closure needs some additional development work. In addition of extensive EB-welding program ultrasonic inspection and creep strength of the weld were studied. According

  6. The design and performance of a twenty barrel hydrogen pellet injector for Alcator C-Mod

    Energy Technology Data Exchange (ETDEWEB)

    Urbahn, J.A.

    1994-05-01

    A twenty barrel hydrogen pellet injector has been designed, built and tested both in the laboratory and on the Alcator C-Mod Tokamak at MIT. The injector functions by firing pellets of frozen hydrogen or deuterium deep into the plasma discharge for the purpose of fueling the plasma, modifying the density profile and increasing the global energy confinement time. The design goals of the injector are: (1) Operational flexibility, (2) High reliability, (3) Remote operation with minimal maintenance. These requirements have lead to a single stage, pipe gun design with twenty barrels. Pellets are formed by in- situ condensation of the fuel gas, thus avoiding moving parts at cryogenic temperatures. The injector is the first to dispense with the need for cryogenic fluids and instead uses a closed cycle refrigerator to cool the thermal system components. The twenty barrels of the injector produce pellets of four different size groups and allow for a high degree of flexibility in fueling experiments. Operation of the injector is under PLC control allowing for remote operation, interlocked safety features and automated pellet manufacturing. The injector has been extrusively tested and shown to produce pellets reliably with velocities up to 1400 m/sec. During the period from September to November of 1993, the injector was successfully used to fire pellets into over fifty plasma discharges. Experimental results include data on the pellet penetration into the plasma using an advanced pellet tracking diagnostic with improved time and spatial response. Data from the tracker indicates pellet penetrations were between 30 and 86 percent of the plasma minor radius.

  7. GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration.

    Directory of Open Access Journals (Sweden)

    Massimilano Scolz

    Full Text Available The regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is necessary for cell migration, but how microtubules and microtubule-associated proteins regulate multiple pathways promoting cell migration remains unclear. Microtubule plus-end binding proteins (+TIPs are emerging as important players in many cellular functions, including cell migration. Here we identify a +TIP, GTSE1, that promotes cell migration. GTSE1 accumulates at growing microtubule plus ends through interaction with the EB1+TIP. The EB1-dependent +TIP activity of GTSE1 is required for cell migration, as well as for microtubule-dependent disassembly of focal adhesions. GTSE1 protein levels determine the migratory capacity of both nontransformed and breast cancer cell lines. In breast cancers, increased GTSE1 expression correlates with invasive potential, tumor stage, and time to distant metastasis, suggesting that misregulation of GTSE1 expression could be associated with increased invasive potential.

  8. Pairwise Correlations of Eight Strong DIBs and N(H), N(H2), and EB-V

    Science.gov (United States)

    Friedman, Scott D.; York, D. G.; McCall, B. J.; Dahlstrom, J.; Sonnentrucker, P.; Welty, D. E.; Drosback, M. M.; Hobbs, L. M.; Rachford, B. L.; Snow, T. P.

    2011-10-01

    We discuss the correlations between equivalent widths of eight diffuse interstellar bands (DIBs), and examine their correlations with the column densities of atomic hydrogen (N(H)) and molecular hydrogen (N(H2)), and EB-V. The DIBs are centered at λ 5780.5, 6204.5, 6283.8, 6196.0, 6613.6, 5705.1, 5797.1, and 5487.7, in decreasing order of Pearson's correlation coefficient with N(H), which ranges from 0.94 to 0.78. The equivalent width of 5780.5 is better correlated with column density of H than with EB-V or H2, and the same is true for six of the seven other DIBs presented here. Hence, they are not preferentially located in the densest, most UV shielded parts of interstellar clouds. These eight strong DIBs are not correlated well enough with each other to suggest they come from the same carrier. However, the correlations may be useful in deriving interstellar parameters, such as N(H) from W(5780.5), when more direct methods are not available. Our future plans include mapping the distribution of DIBs in interstellar clouds, closer examination of the excellent correlation between 5705.1 and 5780.5 (almost as good as the near perfect correlation of 6613.6 with 6196.0), and precise measurements of broad DIBs.

  9. Effects of pH, glucose and iron sulfate concentration on the yield of biohydrogen by Clostridium butyricum EB6

    Energy Technology Data Exchange (ETDEWEB)

    Chong, Mei-Ling; Abdul Rahman, Nor' Aini; Yee, Phang Lai; Aziz, Suraini Abd; Hassan, Mohd Ali [Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor (Malaysia); Rahim, Raha Abdul [Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor (Malaysia); Shirai, Yoshihito [Graduate School of Life Sciences and System Engineering, Kyushu Institute of Technology, 808-0196 Hibikino 2-4, Wakamatsu-ku, Kitakyushu-shi, Fukuoka (Japan)

    2009-11-15

    A local bacterial isolate from palm oil mill effluent (POME) sludge, identified as Clostridium butyricum EB6, was used for biohydrogen production. Optimization of biohydrogen production was performed via statistical analysis, namely response surface methodology (RSM), with respect to pH, glucose and iron concentration. The results show that pH, glucose concentration and iron concentration significantly influenced the biohydrogen gas production individually, interactively and quadratically (P < 0.05). The center composite design (CCD) results indicated that pH 5.6, 15.7 g/L glucose and 0.39 g/L FeSO{sub 4} were the optimal conditions for biohydrogen production, yielding 2.2 mol H{sub 2}/mol glucose. In confirmation of the experimental model, t-test results showed that curve fitted to the experimental data had a high confidence level, at 95% with t = 2.225. Based on the results of this study, optimization of the culture conditions for C. butyricum EB6 significantly increased the production of biohydrogen. (author)

  10. Numerical study on structural integrity of inner barrel caused by thermal stratification in upper plenum of Monju

    International Nuclear Information System (INIS)

    In Japanese prototype fast reactor, Monju, an inner cylinder with several flow holes is placed at the upper plenum adjacent to the core outlet. Liquid sodium heated at the core goes into the upper plenum and flows out to the hot leg piping by overflowing at the top of the inner cylinder and passing through the flow holes. When the reactor scram occurs, a cold coolant flows into the bottom of the upper plenum and the thermal stratification takes place at the upper plenum. And thus, the inner barrel may be damaged by a thermal stress due to the temperature difference of the stratification. In this study, a structural integrity of the inner barrel is evaluated numerically based on the cumulative damage rule. First, the upper plenum of fast reactor is numerically investigated to obtain the time history of the temperature at the inner barrel based on a three dimensional thermal-hydraulic CFD tool (FLUENT code) based on the IAEA benchmark analysis (Reactor scram from 40% power operation).Then, a thermal stresses at each location of the inner barrel is calculated using the time history. With regard to the thermal stress calculation, a simplified model is assumed in which temperature decay due to heat convection through the barrel and heat conduction inside the barrel and heat contraction due to temperature difference caused by the stratification are considered. In addition, a model is combined with the effects of transient heat conduction. Then a cumulative damage factor is obtained at each computational cell of the barrel and is summed up through the stratification phenomenon. It is concluded that no significant cumulative damage is found during the IAEA benchmark condition. It is also notified that a practical damage assessment can be examined numerically using the present method. (author)

  11. The Crystal Barrel: Meson Spectroscopy at LEAR with a 4$\\pi$ Detector

    CERN Multimedia

    2002-01-01

    % PS197 \\\\ \\\\The Crystal Barrel is a 4$\\pi$ spectrometer designed to provide complete and precise information on practically every final state produced in $\\bar{p} p $ and $\\bar{p}d $ annihilations at low energy and to collect high statistics data samples. Selective triggers can be applied when necessary. \\\\ \\\\The physics goal is to identify all light mesons in the mass range from 0.14 to 2.3~GeV/c$^{2}$, to determine their quantum numbers and decay properties and to study the annihilation dynamics. The main interest is to find the glueball and hybrid degrees of freedom predicted in the framework of Quantum Chromodynamics. \\\\ \\\\\

  12. Study of RPC Barrel maximum efficiency in 2012 and 2015 calibration collision runs

    CERN Document Server

    Cassar, Samwel

    2015-01-01

    The maximum efficiency of each of the 1020 Resistive Plate Chamber (RPC) rolls in the barrel region of the CMS muon detector is calculated from the best sigmoid fit of efficiency against high voltage (HV). Data from the HV scans, collected during calibration runs in 2012 and 2015, were compared and the rolls exhibiting a change in maximum efficiency were identified. The chi-square value of the sigmoid fit for each roll was considered in determining the significance of the maximum efficiency for the respective roll.

  13. Twenty barrel in situ pipe gun type solid hydrogen pellet injector for the Large Helical Device

    OpenAIRE

    SAKAMOTO, Ryuichi; MOTOJIMA, Gen; Hayashi, Hiromi; Inoue, Tomoyuki; Ito, Yasuhiko; Ogawa, Hideki; Takami, Shigeyuki; Yokota, Mitsuhiro; Yamada, Hiroshi

    2013-01-01

    A 20 barrel solid hydrogen pellet injector, which is able to inject 20 cylindrical pellets with a diameter and length of between 3.0 and 3.8 mm at the velocity of 1200 m/s, has been developed for the purpose of direct core fueling in LHD (Large Helical Device). The in situ pipe gun concept with the use of compact cryo-coolers enables stable operation as a fundamental facility in plasma experiments. The combination of the two types of pellet injection timing control modes, i.e., pre-programing...

  14. Projects to get you off the grid rain barrels, chicken coops, and solar panels

    CERN Document Server

    Instructablescom

    2014-01-01

    Instructables is back with this compact book focused on a series of projects designed to get you thinking creatively about thinking green. Twenty Instructables illustrate just how simple it can be to make your own backyard chicken coop, or turn a wine barrel into a rainwater collector.Illustrated with dozens of full-color photographs per project accompanying easy-to-follow instructions, this Instructables collection utilizes the best that the online community has to offer, turning a far-reaching group of people into a mammoth database churning out ideas to make life better, easier, and in this

  15. The thermal and magnetic stress analyses of the ATLAS Barrel Toroid- B0 coil

    CERN Document Server

    Sun, Z; Daël, A; Mayri, C; Pes, C; Reytier, M

    2002-01-01

    The B0 coil is a test-model of the ATLAS Barrel Toroid (BT) coils. It has been installed in the test station at CERN. One important item of the B0 test is the strain/stress measurements. In order to determine the expected stress values at the strain gage locations on the coil casing and the tie rods, detailed thermal and magnetic stress analyses of the B0 coil have been carried out. The analysis results are prepared for a later one-to-one comparison with the measurement results. (6 refs).

  16. Barrel time-of-flight detector for the PANDA experiment at FAIR

    Science.gov (United States)

    Gruber, L.; Brunner, S. E.; Marton, J.; Orth, H.; Suzuki, K.

    2016-07-01

    The barrel time-of-flight detector for the PANDA experiment at FAIR is foreseen as a Scintillator Tile (SciTil) Hodoscope based on several thousand small plastic scintillator tiles read-out with directly attached Silicon Photomultipliers (SiPMs). The main tasks of the system are an accurate determination of the time origin of particle tracks to avoid event mixing at high collision rates, relative time-of-flight measurements as well as particle identification in the low momentum regime. The main requirements are the use of a minimum material amount and a time resolution of σ Counter from Philips a time resolution of about 30 ps has been reached.

  17. Results and Consequences of Magnet Test and Cosmic Challenge of the CMS Barrel Muon Alignment System

    CERN Document Server

    Bencze, Gy L; Imrek, J; Molnàr, J; Novàk, D; Raics, P; Sass, V; Szabò, Zs; Svékely, G; Szillàsi, Z; PH-EP

    2007-01-01

    In the last year - as part of the first test of the CMS experiment at CERN [1] called Magnet Test and Cosmic Challenge (MTCC) - about 25% of the barrel muon position monitoring system was built and operated. The configuration enabled us to test all the elements of the system and its function in real conditions. The correct operation of the system has been demonstrated. About 500 full measurement cycles have been recorded. In the paper the setup –including the read-out and control - is described and the first preliminary results are presented.

  18. Precise Mapping of the Magnetic Field in the CMS Barrel Yoke using Cosmic Rays

    CERN Document Server

    Chatrchyan, S; Sirunyan, A M; Adam, W; Arnold, B; Bergauer, H; Bergauer, T; Dragicevic, M; Eichberger, M; Erö, J; Friedl, M; Frühwirth, R; Ghete, V M; Hammer, J; Hänsel, S; Hoch, M; Hörmann, N; Hrubec, J; Jeitler, M; Kasieczka, G; Kastner, K; Krammer, M; Liko, D; Magrans de Abril, I; Mikulec, I; Mittermayr, F; Neuherz, B; Oberegger, M; Padrta, M; Pernicka, M; Rohringer, H; Schmid, S; Schöfbeck, R; Schreiner, T; Stark, R; Steininger, H; Strauss, J; Taurok, A; Teischinger, F; Themel, T; Uhl, D; Wagner, P; Waltenberger, W; Walzel, G; Widl, E; Wulz, C E; Chekhovsky, V; Dvornikov, O; Emeliantchik, I; Litomin, A; Makarenko, V; Marfin, I; Mossolov, V; Shumeiko, N; Solin, A; Stefanovitch, R; Suarez Gonzalez, J; Tikhonov, A; Fedorov, A; Karneyeu, A; Korzhik, M; Panov, V; Zuyeuski, R; Kuchinsky, P; Beaumont, W; Benucci, L; Cardaci, M; De Wolf, E A; Delmeire, E; Druzhkin, D; Hashemi, M; Janssen, X; Maes, T; Mucibello, L; Ochesanu, S; Rougny, R; Selvaggi, M; Van Haevermaet, H; Van Mechelen, P; Van Remortel, N; Adler, V; Beauceron, S; Blyweert, S; D'Hondt, J; De Weirdt, S; Devroede, O; Heyninck, J; Kalogeropoulos, A; Maes, J; Maes, M; Mozer, M U; Tavernier, S; Van Doninck, W; Van Mulders, P; Villella, I; Bouhali, O; Chabert, E C; Charaf, O; Clerbaux, B; De Lentdecker, G; Dero, V; Elgammal, S; Gay, A P R; Hammad, G H; Marage, P E; Rugovac, S; Vander Velde, C; Vanlaer, P; Wickens, J; Grunewald, M; Klein, B; Marinov, A; Ryckbosch, D; Thyssen, F; Tytgat, M; Vanelderen, L; Verwilligen, P; Basegmez, S; Bruno, G; Caudron, J; Delaere, C; Demin, P; Favart, D; Giammanco, A; Grégoire, G; Lemaitre, V; Militaru, O; Ovyn, S; Piotrzkowski, K; Quertenmont, L; Schul, N; Beliy, N; Daubie, E; Alves, G A; Pol, M E; Souza, M H G; Carvalho, W; De Jesus Damiao, D; De Oliveira Martins, C; Fonseca De Souza, S; Mundim, L; Oguri, V; Santoro, A; Silva Do Amaral, S M; Sznajder, A; Fernandez Perez Tomei, T R; Ferreira Dias, M A; Gregores, E M; Novaes, S F; Abadjiev, K; Anguelov, T; Damgov, J; Darmenov, N; Dimitrov, L; Genchev, V; Iaydjiev, P; Piperov, S; Stoykova, S; Sultanov, G; Trayanov, R; Vankov, I; Dimitrov, A; Dyulendarova, M; Kozhuharov, V; Litov, L; Marinova, E; Mateev, M; Pavlov, B; Petkov, P; Toteva, Z; Chen, G M; Chen, H S; Guan, W; Jiang, C H; Liang, D; Liu, B; Meng, X; Tao, J; Wang, J; Wang, Z; Xue, Z; Zhang, Z; Ban, Y; Cai, J; Ge, Y; Guo, S; Hu, Z; Mao, Y; Qian, S J; Teng, H; Zhu, B; Avila, C; Baquero Ruiz, M; Carrillo Montoya, C A; Gomez, A; Gomez Moreno, B; Ocampo Rios, A A; Osorio Oliveros, A F; Reyes Romero, D; Sanabria, J C; Godinovic, N; Lelas, K; Plestina, R; Polic, D; Puljak, I; Antunovic, Z; Dzelalija, M; Brigljevic, V; Duric, S; Kadija, K; Morovic, S; Fereos, R; Galanti, M; Mousa, J; Papadakis, A; Ptochos, F; Razis, P A; Tsiakkouri, D; Zinonos, Z; Hektor, A; Kadastik, M; Kannike, K; Müntel, M; Raidal, M; Rebane, L; Anttila, E; Czellar, S; Härkönen, J; Heikkinen, A; Karimäki, V; Kinnunen, R; Klem, J; Kortelainen, M J; Lampén, T; Lassila-Perini, K; Lehti, S; Lindén, T; Luukka, P; Mäenpää, T; Nysten, J; Tuominen, E; Tuominiemi, J; Ungaro, D; Wendland, L; Banzuzi, K; Korpela, A; Tuuva, T; Nedelec, P; Sillou, D; Besancon, M; Chipaux, R; Dejardin, M; Denegri, D; Descamps, J; Fabbro, B; Faure, J L; Ferri, F; Ganjour, S; Gentit, F X; Givernaud, A; Gras, P; Hamel de Monchenault, G; Jarry, P; Lemaire, M C; Locci, E; Malcles, J; Marionneau, M; Millischer, L; Rander, J; Rosowsky, A; Rousseau, D; Titov, M; Verrecchia, P; Baffioni, S; Bianchini, L; Bluj, M; Busson, P; Charlot, C; Dobrzynski, L; Granier de Cassagnac, R; Haguenauer, M; Miné, P; Paganini, P; Sirois, Y; Thiebaux, C; Zabi, A; Agram, J L; Besson, A; Bloch, D; Bodin, D; Brom, J M; Conte, E; Drouhin, F; Fontaine, J C; Gelé, D; Goerlach, U; Gross, L; Juillot, P; Le Bihan, A C; Patois, Y; Speck, J; Van Hove, P; Baty, C; Bedjidian, M; Blaha, J; Boudoul, G; Brun, H; Chanon, N; Chierici, R; Contardo, D; Depasse, P; Dupasquier, T; El Mamouni, H; Fassi, F; Fay, J; Gascon, S; Ille, B; Kurca, T; Le Grand, T; Lethuillier, M; Lumb, N; Mirabito, L; Perries, S; Vander Donckt, M; Verdier, P; Djaoshvili, N; Roinishvili, N; Roinishvili, V; Amaglobeli, N; Adolphi, R; Anagnostou, G; Brauer, R; Braunschweig, W; Edelhoff, M; Esser, H; Feld, L; Karpinski, W; Khomich, A; Klein, K; Mohr, N; Ostaptchouk, A; Pandoulas, D; Pierschel, G; Raupach, F; Schael, S; Schultz von Dratzig, A; Schwering, G; Sprenger, D; Thomas, M; Weber, M; Wittmer, B; Wlochal, M; Actis, O; Altenhöfer, G; Bender, W; Biallass, P; Erdmann, M; Fetchenhauer, G; Frangenheim, J; Hebbeker, T; Hilgers, G; Hinzmann, A; Hoepfner, K; Hof, C; Kirsch, M; Klimkovich, T; Kreuzer, P; Lanske, D; Merschmeyer, M; Meyer, A; Philipps, B; Pieta, H; Reithler, H; Schmitz, S A; Sonnenschein, L; Sowa, M; Steggemann, J; Szczesny, H; Teyssier, D; Zeidler, C; Bontenackels, M; Davids, M; Duda, M; Flügge, G; Geenen, H; Giffels, M; Haj Ahmad, W; Hermanns, T; Heydhausen, D; Kalinin, S; Kress, T; Linn, A; Nowack, A; Perchalla, L; Poettgens, M; Pooth, O; Sauerland, P; Stahl, A; Tornier, D; Zoeller, M H; Aldaya Martin, M; Behrens, U; Borras, K; Campbell, A; Castro, E; Dammann, D; Eckerlin, G; Flossdorf, A; Flucke, G; Geiser, A; Hatton, D; Hauk, J; Jung, H; Kasemann, M; Katkov, I; Kleinwort, C; Kluge, H; Knutsson, A; Kuznetsova, E; Lange, W; Lohmann, W; Mankel, R; Marienfeld, M; Meyer, A B; Miglioranzi, S; Mnich, J; Ohlerich, M; Olzem, J; Parenti, A; Rosemann, C; Schmidt, R; Schoerner-Sadenius, T; Volyanskyy, D; Wissing, C; Zeuner, W D; Autermann, C; Bechtel, F; Draeger, J; Eckstein, D; Gebbert, U; Kaschube, K; Kaussen, G; Klanner, R; Mura, B; Naumann-Emme, S; Nowak, F; Pein, U; Sander, C; Schleper, P; Schum, T; Stadie, H; Steinbrück, G; Thomsen, J; Wolf, R; Bauer, J; Blüm, P; Buege, V; Cakir, A; Chwalek, T; De Boer, W; Dierlamm, A; Dirkes, G; Feindt, M; Felzmann, U; Frey, M; Furgeri, A; Gruschke, J; Hackstein, C; Hartmann, F; Heier, S; Heinrich, M; Held, H; Hirschbuehl, D; Hoffmann, K H; Honc, S; Jung, C; Kuhr, T; Liamsuwan, T; Martschei, D; Mueller, S; Müller, Th; Neuland, M B; Niegel, M; Oberst, O; Oehler, A; Ott, J; Peiffer, T; Piparo, D; Quast, G; Rabbertz, K; Ratnikov, F; Ratnikova, N; Renz, M; Saout, C; Sartisohn, G; Scheurer, A; Schieferdecker, P; Schilling, F P; Schott, G; Simonis, H J; Stober, F M; Sturm, P; Troendle, D; Trunov, A; Wagner, W; Wagner-Kuhr, J; Zeise, M; Zhukov, V; Ziebarth, E B; Daskalakis, G; Geralis, T; Karafasoulis, K; Kyriakis, A; Loukas, D; Markou, A; Markou, C; Mavrommatis, C; Petrakou, E; Zachariadou, A; Gouskos, L; Katsas, P; Panagiotou, A; Evangelou, I; Kokkas, P; Manthos, N; Papadopoulos, I; Patras, V; Triantis, F A; Bencze, G; Boldizsar, L; Debreczeni, G; Hajdu, C; Hernath, S; Hidas, P; Horvath, D; Krajczar, K; Laszlo, A; Patay, G; Sikler, F; Toth, N; Vesztergombi, G; Beni, N; Christian, G; Imrek, J; Molnar, J; Novak, D; Palinkas, J; Szekely, G; Szillasi, Z; Tokesi, K; Veszpremi, V; Kapusi, A; Marian, G; Raics, P; Szabo, Z; Trocsanyi, Z L; Ujvari, B; Zilizi, G; Bansal, S; Bawa, H S; Beri, S B; Bhatnagar, V; Jindal, M; Kaur, M; Kaur, R; Kohli, J M; Mehta, M Z; Nishu, N; Saini, L K; Sharma, A; Singh, A; Singh, J B; Singh, S P; Ahuja, S; Arora, S; Bhattacharya, S; Chauhan, S; Choudhary, B C; Gupta, P; Jain, S; Jain, S; Jha, M; Kumar, A; Ranjan, K; Shivpuri, R K; Srivastava, A K; Choudhury, R K; Dutta, D; Kailas, S; Kataria, S K; Mohanty, A K; Pant, L M; Shukla, P; Topkar, A; Aziz, T; Guchait, M; Gurtu, A; Maity, M; Majumder, D; Majumder, G; Mazumdar, K; Nayak, A; Saha, A; Sudhakar, K; Banerjee, S; Dugad, S; Mondal, N K; Arfaei, H; Bakhshiansohi, H; Fahim, A; Jafari, A; Mohammadi Najafabadi, M; Moshaii, A; Paktinat Mehdiabadi, S; Rouhani, S; Safarzadeh, B; Zeinali, M; Felcini, M; Abbrescia, M; Barbone, L; Chiumarulo, F; Clemente, A; Colaleo, A; Creanza, D; Cuscela, G; De Filippis, N; De Palma, M; De Robertis, G; Donvito, G; Fedele, F; Fiore, L; Franco, M; Iaselli, G; Lacalamita, N; Loddo, F; Lusito, L; Maggi, G; Maggi, M; Manna, N; Marangelli, B; My, S; Natali, S; Nuzzo, S; Papagni, G; Piccolomo, S; Pierro, G A; Pinto, C; Pompili, A; Pugliese, G; Rajan, R; Ranieri, A; Romano, F; Roselli, G; Selvaggi, G; Shinde, Y; Silvestris, L; Tupputi, S; Zito, G; Abbiendi, G; Bacchi, W; Benvenuti, A C; Boldini, M; Bonacorsi, D; Braibant-Giacomelli, S; Cafaro, V D; Caiazza, S S; Capiluppi, P; Castro, A; Cavallo, F R; Codispoti, G; Cuffiani, M; D'Antone, I; Dallavalle, G M; Fabbri, F; Fanfani, A; Fasanella, D; Giacomelli, P; Giordano, V; Giunta, M; Grandi, C; Guerzoni, M; Marcellini, S; Masetti, G; Montanari, A; Navarria, F L; Odorici, F; Pellegrini, G; Perrotta, A; Rossi, A M; Rovelli, T; Siroli, G; Torromeo, G; Travaglini, R; Albergo, S; Costa, S; Potenza, R; Tricomi, A; Tuve, C; Barbagli, G; Broccolo, G; Ciulli, V; Civinini, C; D'Alessandro, R; Focardi, E; Frosali, S; Gallo, E; Genta, C; Landi, G; Lenzi, P; Meschini, M; Paoletti, S; Sguazzoni, G; Tropiano, A; Benussi, L; Bertani, M; Bianco, S; Colafranceschi, S; Colonna, D; Fabbri, F; Giardoni, M; Passamonti, L; Piccolo, D; Pierluigi, D; Ponzio, B; Russo, A; Fabbricatore, P; Musenich, R; Benaglia, A; Calloni, M; Cerati, G B; D'Angelo, P; De Guio, F; Farina, F M; Ghezzi, A; Govoni, P; Malberti, M; Malvezzi, S; Martelli, A; Menasce, D; Miccio, V; Moroni, L; Negri, P; Paganoni, M; Pedrini, D; Pullia, A; Ragazzi, S; Redaelli, N; Sala, S; Salerno, R; Tabarelli de Fatis, T; Tancini, V; Taroni, S; Buontempo, S; Cavallo, N; Cimmino, A; De Gruttola, M; Fabozzi, F; Iorio, A O M; Lista, L; Lomidze, D; Noli, P; Paolucci, P; Sciacca, C; Azzi, P; Bacchetta, N; Barcellan, L; Bellan, P; Bellato, M; Benettoni, M; Biasotto, M; Bisello, D; Borsato, E; Branca, A; Carlin, R; Castellani, L; Checchia, P; Conti, E; Dal Corso, F; De Mattia, M; Dorigo, T; Dosselli, U; Fanzago, F; Gasparini, F; Gasparini, U; Giubilato, P; Gonella, F; Gresele, A; Gulmini, M; Kaminskiy, A; Lacaprara, S; Lazzizzera, I; Margoni, M; Maron, G; Mattiazzo, S; Mazzucato, M; Meneghelli, M; Meneguzzo, A T; Michelotto, M; Montecassiano, F; Nespolo, M; Passaseo, M; Pegoraro, M; Perrozzi, L; Pozzobon, N; Ronchese, P; Simonetto, F; Toniolo, N; Torassa, E; Tosi, M; Triossi, A; Vanini, S; Ventura, S; Zotto, P; Zumerle, G; Baesso, P; Berzano, U; Bricola, S; Necchi, M M; Pagano, D; Ratti, S P; Riccardi, C; Torre, P; Vicini, A; Vitulo, P; Viviani, C; Aisa, D; Aisa, S; Babucci, E; Biasini, M; Bilei, G M; Caponeri, B; Checcucci, B; Dinu, N; Fanò, L; Farnesini, L; Lariccia, P; Lucaroni, A; Mantovani, G; Nappi, A; Piluso, A; Postolache, V; Santocchia, A; Servoli, L; Tonoiu, D; Vedaee, A; Volpe, R; Azzurri, P; Bagliesi, G; Bernardini, J; Berretta, L; Boccali, T; Bocci, A; Borrello, L; Bosi, F; Calzolari, F; Castaldi, R; Dell'Orso, R; Fiori, F; Foà, L; Gennai, S; Giassi, A; Kraan, A; Ligabue, F; Lomtadze, T; Mariani, F; Martini, L; Massa, M; Messineo, A; Moggi, A; Palla, F; Palmonari, F; Petragnani, G; Petrucciani, G; Raffaelli, F; Sarkar, S; Segneri, G; Serban, A T; Spagnolo, P; Tenchini, R; Tolaini, S; Tonelli, G; Venturi, A; Verdini, P G; Baccaro, S; Barone, L; Bartoloni, A; Cavallari, F; Dafinei, I; Del Re, D; Di Marco, E; Diemoz, M; Franci, D; Longo, E; Organtini, G; Palma, A; Pandolfi, F; Paramatti, R; Pellegrino, F; Rahatlou, S; Rovelli, C; Alampi, G; Amapane, N; Arcidiacono, R; Argiro, S; Arneodo, M; Biino, C; Borgia, M A; Botta, C; Cartiglia, N; Castello, R; Cerminara, G; Costa, M; Dattola, D; Dellacasa, G; Demaria, N; Dughera, G; Dumitrache, F; Graziano, A; Mariotti, C; Marone, M; Maselli, S; Migliore, E; Mila, G; Monaco, V; Musich, M; Nervo, M; Obertino, M M; Oggero, S; Panero, R; Pastrone, N; Pelliccioni, M; Romero, A; Ruspa, M; Sacchi, R; Solano, A; Staiano, A; Trapani, P P; Trocino, D; Vilela Pereira, A; Visca, L; Zampieri, A; Ambroglini, F; Belforte, S; Cossutti, F; Della Ricca, G; Gobbo, B; Penzo, A; Chang, S; Chung, J; Kim, D H; Kim, G N; Kong, D J; Park, H; Son, D C; Bahk, S Y; Song, S; Jung, S Y; Hong, B; Kim, H; Kim, J H; Lee, K S; Moon, D H; Park, S K; Rhee, H B; Sim, K S; Kim, J; Choi, M; Hahn, G; Park, I C; Choi, S; Choi, Y; Goh, J; Jeong, H; Kim, T J; Lee, J; Lee, S; Janulis, M; Martisiute, D; Petrov, P; Sabonis, T; Castilla Valdez, H; Sánchez Hernández, A; Carrillo Moreno, S; Morelos Pineda, A; Allfrey, P; Gray, R N C; Krofcheck, D; Bernardino Rodrigues, N; Butler, P H; Signal, T; Williams, J C; Ahmad, M; Ahmed, I; Ahmed, W; Asghar, M I; Awan, M I M; Hoorani, H R; Hussain, I; Khan, W A; Khurshid, T; Muhammad, S; Qazi, S; Shahzad, H; Cwiok, M; Dabrowski, R; Dominik, W; Doroba, K; Konecki, M; Krolikowski, J; Pozniak, K; Romaniuk, Ryszard; Zabolotny, W; Zych, P; Frueboes, T; Gokieli, R; Goscilo, L; Górski, M; Kazana, M; Nawrocki, K; Szleper, M; Wrochna, G; Zalewski, P; Almeida, N; Antunes Pedro, L; Bargassa, P; David, A; Faccioli, P; Ferreira Parracho, P G; Freitas Ferreira, M; Gallinaro, M; Guerra Jordao, M; Martins, P; Mini, G; Musella, P; Pela, J; Raposo, L; Ribeiro, P Q; Sampaio, S; Seixas, J; Silva, J; Silva, P; Soares, D; Sousa, M; Varela, J; Wöhri, H K; Altsybeev, I; Belotelov, I; Bunin, P; Ershov, Y; Filozova, I; Finger, M; Finger, M Jr; Golunov, A; Golutvin, I; Gorbounov, N; Kalagin, V; Kamenev, A; Karjavin, V; Konoplyanikov, V; Korenkov, V; Kozlov, G; Kurenkov, A; Lanev, A; Makankin, A; Mitsyn, V V; Moisenz, P; Nikonov, E; Oleynik, D; Palichik, V; Perelygin, V; Petrosyan, A; Semenov, R; Shmatov, S; Smirnov, V; Smolin, D; Tikhonenko, E; Vasil'ev, S; Vishnevskiy, A; Volodko, A; Zarubin, A; Zhiltsov, V; Bondar, N; Chtchipounov, L; Denisov, A; Gavrikov, Y; Gavrilov, G; Golovtsov, V; Ivanov, Y; Kim, V; Kozlov, V; Levchenko, P; Obrant, G; Orishchin, E; Petrunin, A; Shcheglov, Y; Shchetkovskiy, A; Sknar, V; Smirnov, I; Sulimov, V; Tarakanov, V; Uvarov, L; Vavilov, S; Velichko, G; Volkov, S; Vorobyev, A; Andreev, Yu; Anisimov, A; Antipov, P; Dermenev, A; Gninenko, S; Golubev, N; Kirsanov, M; Krasnikov, N; Matveev, V; Pashenkov, A; Postoev, V E; Solovey, A; Solovey, A; Toropin, A; Troitsky, S; Baud, A; Epshteyn, V; Gavrilov, V; Ilina, N; Kaftanov, V; Kolosov, V; Kossov, M; Krokhotin, A; Kuleshov, S; Oulianov, A; Safronov, G; Semenov, S; Shreyber, I; Stolin, V; Vlasov, E; Zhokin, A; Boos, E; Dubinin, M; Dudko, L; Ershov, A; Gribushin, A; Klyukhin, V; Kodolova, O; Lokhtin, I; Petrushanko, S; Sarycheva, L; Savrin, V; Snigirev, A; Vardanyan, I; Dremin, I; Kirakosyan, M; Konovalova, N; Rusakov, S V; Vinogradov, A; Akimenko, S; Artamonov, A; Azhgirey, I; Bitioukov, S; Burtovoy, V; Grishin, V; Kachanov, V; Konstantinov, D; Krychkine, V; Levine, A; Lobov, I; Lukanin, V; Mel'nik, Y; Petrov, V; Ryutin, R; Slabospitsky, S; Sobol, A; Sytine, A; Tourtchanovitch, L; Troshin, S; Tyurin, N; Uzunian, A; Volkov, A; Adzic, P; Djordjevic, M; Jovanovic, D; Krpic, D; Maletic, D; Puzovic, J; Smiljkovic, N; Aguilar-Benitez, M; Alberdi, J; Alcaraz Maestre, J; Arce, P; Barcala, J M; Battilana, C; Burgos Lazaro, C; Caballero Bejar, J; Calvo, E; Cardenas Montes, M; Cepeda, M; Cerrada, M; Chamizo Llatas, M; Clemente, F; Colino, N; Daniel, M; De La Cruz, B; Delgado Peris, A; Diez Pardos, C; Fernandez Bedoya, C; Fernández Ramos, J P; Ferrando, A; Flix, J; Fouz, M C; Garcia-Abia, P; Garcia-Bonilla, A C; Gonzalez Lopez, O; Goy Lopez, S; Hernandez, J M; Josa, M I; Marin, J; Merino, G; Molina, J; Molinero, A; Navarrete, J J; Oller, J C; Puerta Pelayo, J; Romero, L; Santaolalla, J; Villanueva Munoz, C; Willmott, C; Yuste, C; Albajar, C; Blanco Otano, M; de Trocóniz, J F; Garcia Raboso, A; Lopez Berengueres, J O; Cuevas, J; Fernandez Menendez, J; Gonzalez Caballero, I; Lloret Iglesias, L; Naves Sordo, H; Vizan Garcia, J M; Cabrillo, I J; Calderon, A; Chuang, S H; Diaz Merino, I; Diez Gonzalez, C; Duarte Campderros, J; Fernandez, M; Gomez, G; Gonzalez Sanchez, J; Gonzalez Suarez, R; Jorda, C; Lobelle Pardo, P; Lopez Virto, A; Marco, J; Marco, R; Martinez Rivero, C; Martinez Ruiz del Arbol, P; Matorras, F; Rodrigo, T; Ruiz Jimeno, A; Scodellaro, L; Sobron Sanudo, M; Vila, I; Vilar Cortabitarte, R; Abbaneo, D; Albert, E; Alidra, M; Ashby, S; Auffray, E; Baechler, J; Baillon, P; Ball, A H; Bally, S L; Barney, D; Beaudette, F; Bellan, R; Benedetti, D; Benelli, G; Bernet, C; Bloch, P; Bolognesi, S; Bona, M; Bos, J; Bourgeois, N; Bourrel, T; Breuker, H; Bunkowski, K; Campi, D; Camporesi, T; Cano, E; Cattai, A; Chatelain, J P; Chauvey, M; Christiansen, T; Coarasa Perez, J A; Conde Garcia, A; Covarelli, R; Curé, B; De Roeck, A; Delachenal, V; Deyrail, D; Di Vincenzo, S; Dos Santos, S; Dupont, T; Edera, L M; Elliott-Peisert, A; Eppard, M; Favre, M; Frank, N; Funk, W; Gaddi, A; Gastal, M; Gateau, M; Gerwig, H; Gigi, D; Gill, K; Giordano, D; Girod, J P; Glege, F; Gomez-Reino Garrido, R; Goudard, R; Gowdy, S; Guida, R; Guiducci, L; Gutleber, J; Hansen, M; Hartl, C; Harvey, J; Hegner, B; Hoffmann, H F; Holzner, A; Honma, A; Huhtinen, M; Innocente, V; Janot, P; Le Godec, G; Lecoq, P; Leonidopoulos, C; Loos, R; Lourenço, C; Lyonnet, A; Macpherson, A; Magini, N; Maillefaud, J D; Maire, G; Mäki, T; Malgeri, L; Mannelli, M; Masetti, L; Meijers, F; Meridiani, P; Mersi, S; Meschi, E; Meynet Cordonnier, A; Moser, R; Mulders, M; Mulon, J; Noy, M; Oh, A; Olesen, G; Onnela, A; Orimoto, T; Orsini, L; Perez, E; Perinic, G; Pernot, J F; Petagna, P; Petiot, P; Petrilli, A; Pfeiffer, A; Pierini, M; Pimiä, M; Pintus, R; Pirollet, B; Postema, H; Racz, A; Ravat, S; Rew, S B; Rodrigues Antunes, J; Rolandi, G; Rovere, M; Ryjov, V; Sakulin, H; Samyn, D; Sauce, H; Schäfer, C; Schlatter, W D; Schröder, M; Schwick, C; Sciaba, A; Segoni, I; Sharma, A; Siegrist, N; Siegrist, P; Sinanis, N; Sobrier, T; Sphicas, P; Spiga, D; Spiropulu, M; Stöckli, F; Traczyk, P; Tropea, P; Troska, J; Tsirou, A; Veillet, L; Veres, G I; Voutilainen, M; Wertelaers, P; Zanetti, M; Bertl, W; Deiters, K; Erdmann, W; Gabathuler, K; Horisberger, R; Ingram, Q; Kaestli, H C; König, S; Kotlinski, D; Langenegger, U; Meier, F; Renker, D; Rohe, T; Sibille, J; Starodumov, A; Betev, B; Caminada, L; Chen, Z; Cittolin, S; Da Silva Di Calafiori, D R; Dambach, S; Dissertori, G; Dittmar, M; Eggel, C; Eugster, J; Faber, G; Freudenreich, K; Grab, C; Hervé, A; Hintz, W; Lecomte, P; Luckey, P D; Lustermann, W; Marchica, C; Milenovic, P; Moortgat, F; Nardulli, A; Nessi-Tedaldi, F; Pape, L; Pauss, F; Punz, T; Rizzi, A; Ronga, F J; Sala, L; Sanchez, A K; Sawley, M C; Sordini, V; Stieger, B; Tauscher, L; Thea, A; Theofilatos, K; Treille, D; Trüb, P; Weber, M; Wehrli, L; Weng, J; Zelepoukine, S; Amsler, C; Chiochia, V; De Visscher, S; Regenfus, C; Robmann, P; Rommerskirchen, T; Schmidt, A; Tsirigkas, D; Wilke, L; Chang, Y H; Chen, E A; Chen, W T; Go, A; Kuo, C M; Li, S W; Lin, W; Bartalini, P; Chang, P; Chao, Y; Chen, K F; Hou, W S; Hsiung, Y; Lei, Y J; Lin, S W; Lu, R S; Schümann, J; Shiu, J G; Tzeng, Y M; Ueno, K; Velikzhanin, Y; Wang, C C; Wang, M; Adiguzel, A; Ayhan, A; Azman Gokce, A; Bakirci, M N; Cerci, S; Dumanoglu, I; Eskut, E; Girgis, S; Gurpinar, E; Hos, I; Karaman, T; Karaman, T; Kayis Topaksu, A; Kurt, P; Önengüt, G; Önengüt Gökbulut, G; Ozdemir, K; Ozturk, S; Polatöz, A; Sogut, K; Tali, B; Topakli, H; Uzun, D; Vergili, L N; Vergili, M; Akin, I V; Aliev, T; Bilmis, S; Deniz, M; Gamsizkan, H; Guler, A M; Öcalan, K; Serin, M; Sever, R; Surat, U E; Zeyrek, M; Deliomeroglu, M; Demir, D; Gülmez, E; Halu, A; Isildak, B; Kaya, M; Kaya, O; Ozkorucuklu, S; Sonmez, N; Levchuk, L; Lukyanenko, S; Soroka, D; Zub, S; Bostock, F; Brooke, J J; Cheng, T L; Cussans, D; Frazier, R; Goldstein, J; Grant, N; Hansen, M; Heath, G P; Heath, H F; Hill, C; Huckvale, B; Jackson, J; Mackay, C K; Metson, S; Newbold, D M; Nirunpong, K; Smith, V J; Velthuis, J; Walton, R; Bell, K W; Brew, C; Brown, R M; Camanzi, B; Cockerill, D J A; Coughlan, J A; Geddes, N I; Harder, K; Harper, S; Kennedy, B W; Murray, P; Shepherd-Themistocleous, C H; Tomalin, I R; Williams, J H; Womersley, W J; Worm, S D; Bainbridge, R; Ball, G; Ballin, J; Beuselinck, R; Buchmuller, O; Colling, D; Cripps, N; Davies, G; Della Negra, M; Foudas, C; Fulcher, J; Futyan, D; Hall, G; Hays, J; Iles, G; Karapostoli, G; MacEvoy, B C; Magnan, A M; Marrouche, J; Nash, J; Nikitenko, A; Papageorgiou, A; Pesaresi, M; Petridis, K; Pioppi, M; Raymond, D M; Rompotis, N; Rose, A; Ryan, M J; Seez, C; Sharp, P; Sidiropoulos, G; Stettler, M; Stoye, M; Takahashi, M; Tapper, A; Timlin, C; Tourneur, S; Vazquez Acosta, M; Virdee, T; Wakefield, S; Wardrope, D; Whyntie, T; Wingham, M; Cole, J E; Goitom, I; Hobson, P R; Khan, A; Kyberd, P; Leslie, D; Munro, C; Reid, I D; Siamitros, C; Taylor, R; Teodorescu, L; Yaselli, I; Bose, T; Carleton, M; Hazen, E; Heering, A H; Heister, A; John, J St; Lawson, P; Lazic, D; Osborne, D; Rohlf, J; Sulak, L; Wu, S; Andrea, J; Avetisyan, A; Bhattacharya, S; Chou, J P; Cutts, D; Esen, S; Kukartsev, G; Landsberg, G; Narain, M; Nguyen, D; Speer, T; Tsang, K V; Breedon, R; Calderon De La Barca Sanchez, M; Case, M; Cebra, D; Chertok, M; Conway, J; Cox, P T; Dolen, J; Erbacher, R; Friis, E; Ko, W; Kopecky, A; Lander, R; Lister, A; Liu, H; Maruyama, S; Miceli, T; Nikolic, M; Pellett, D; Robles, J; Searle, M; Smith, J; Squires, M; Stilley, J; Tripathi, M; Vasquez Sierra, R; Veelken, C; Andreev, V; Arisaka, K; Cline, D; Cousins, R; Erhan, S; Hauser, J; Ignatenko, M; Jarvis, C; Mumford, J; Plager, C; Rakness, G; Schlein, P; Tucker, J; Valuev, V; Wallny, R; Yang, X; Babb, J; Bose, M; Chandra, A; Clare, R; Ellison, J A; Gary, J W; Hanson, G; Jeng, G Y; Kao, S C; Liu, F; Liu, H; Luthra, A; Nguyen, H; Pasztor, G; Satpathy, A; Shen, B C; Stringer, R; Sturdy, J; Sytnik, V; Wilken, R; Wimpenny, S; Branson, J G; Dusinberre, E; Evans, D; Golf, F; Kelley, R; Lebourgeois, M; Letts, J; Lipeles, E; Mangano, B; Muelmenstaedt, J; Norman, M; Padhi, S; Petrucci, A; Pi, H; Pieri, M; Ranieri, R; Sani, M; Sharma, V; Simon, S; Würthwein, F; Yagil, A; Campagnari, C; D'Alfonso, M; Danielson, T; Garberson, J; Incandela, J; Justus, C; Kalavase, P; Koay, S A; Kovalskyi, D; Krutelyov, V; Lamb, J; Lowette, S; Pavlunin, V; Rebassoo, F; Ribnik, J; Richman, J; Rossin, R; Stuart, D; To, W; Vlimant, J R; Witherell, M; Apresyan, A; Bornheim, A; Bunn, J; Chiorboli, M; Gataullin, M; Kcira, D; Litvine, V; Ma, Y; Newman, H B; Rogan, C; Timciuc, V; Veverka, J; Wilkinson, R; Yang, Y; Zhang, L; Zhu, K; Zhu, R Y; Akgun, B; Carroll, R; Ferguson, T; Jang, D W; Jun, S Y; Paulini, M; Russ, J; Terentyev, N; Vogel, H; Vorobiev, I; Cumalat, J P; Dinardo, M E; Drell, B R; Ford, W T; Heyburn, B; Luiggi Lopez, E; Nauenberg, U; Stenson, K; Ulmer, K; Wagner, S R; Zang, S L; Agostino, L; Alexander, J; Blekman, F; Cassel, D; Chatterjee, A; Das, S; Gibbons, L K; Heltsley, B; Hopkins, W; Khukhunaishvili, A; Kreis, B; Kuznetsov, V; Patterson, J R; Puigh, D; Ryd, A; Shi, X; Stroiney, S; Sun, W; Teo, W D; Thom, J; Vaughan, J; Weng, Y; Wittich, P; Beetz, C P; Cirino, G; Sanzeni, C; Winn, D; Abdullin, S; Afaq, M A; Albrow, M; Ananthan, B; Apollinari, G; Atac, M; Badgett, W; Bagby, L; Bakken, J A; Baldin, B; Banerjee, S; Banicz, K; Bauerdick, L A T; Beretvas, A; Berryhill, J; Bhat, P C; Biery, K; Binkley, M; Bloch, I; Borcherding, F; Brett, A M; Burkett, K; Butler, J N; Chetluru, V; Cheung, H W K; Chlebana, F; Churin, I; Cihangir, S; Crawford, M; Dagenhart, W; Demarteau, M; Derylo, G; Dykstra, D; Eartly, D P; Elias, J E; Elvira, V D; Evans, D; Feng, L; Fischler, M; Fisk, I; Foulkes, S; Freeman, J; Gartung, P; Gottschalk, E; Grassi, T; Green, D; Guo, Y; Gutsche, O; Hahn, A; Hanlon, J; Harris, R M; Holzman, B; Howell, J; Hufnagel, D; James, E; Jensen, H; Johnson, M; Jones, C D; Joshi, U; Juska, E; Kaiser, J; Klima, B; Kossiakov, S; Kousouris, K; Kwan, S; Lei, C M; Limon, P; Lopez Perez, J A; Los, S; Lueking, L; Lukhanin, G; Lusin, S; Lykken, J; Maeshima, K; Marraffino, J M; Mason, D; McBride, P; Miao, T; Mishra, K; Moccia, S; Mommsen, R; Mrenna, S; Muhammad, A S; Newman-Holmes, C; Noeding, C; O'Dell, V; Prokofyev, O; Rivera, R; Rivetta, C H; Ronzhin, A; Rossman, P; Ryu, S; Sekhri, V; Sexton-Kennedy, E; Sfiligoi, I; Sharma, S; Shaw, T M; Shpakov, D; Skup, E; Smith, R P; Soha, A; Spalding, W J; Spiegel, L; Suzuki, I; Tan, P; Tanenbaum, W; Tkaczyk, S; Trentadue, R; Uplegger, L; Vaandering, E W; Vidal, R; Whitmore, J; Wicklund, E; Wu, W; Yarba, J; Yumiceva, F; Yun, J C; Acosta, D; Avery, P; Barashko, V; Bourilkov, D; Chen, M; Di Giovanni, G P; Dobur, D; Drozdetskiy, A; Field, R D; Fu, Y; Furic, I K; Gartner, J; Holmes, D; Kim, B; Klimenko, S; Konigsberg, J; Korytov, A; Kotov, K; Kropivnitskaya, A; Kypreos, T; Madorsky, A; Matchev, K; Mitselmakher, G; Pakhotin, Y; Piedra Gomez, J; Prescott, C; Rapsevicius, V; Remington, R; Schmitt, M; Scurlock, B; Wang, D; Yelton, J; Ceron, C; Gaultney, V; Kramer, L; Lebolo, L M; Linn, S; Markowitz, P; Martinez, G; Rodriguez, J L; Adams, T; Askew, A; Baer, H; Bertoldi, M; Chen, J; Dharmaratna, W G D; Gleyzer, S V; Haas, J; Hagopian, S; Hagopian, V; Jenkins, M; Johnson, K F; Prettner, E; Prosper, H; Sekmen, S; Baarmand, M M; Guragain, S; Hohlmann, M; Kalakhety, H; Mermerkaya, H; Ralich, R; Vodopiyanov, I; Abelev, B; Adams, M R; Anghel, I M; Apanasevich, L; Bazterra, V E; Betts, R R; Callner, J; Castro, M A; Cavanaugh, R; Dragoiu, C; Garcia-Solis, E J; Gerber, C E; Hofman, D J; Khalatian, S; Mironov, C; Shabalina, E; Smoron, A; Varelas, N; Akgun, U; Albayrak, E A; Ayan, A S; Bilki, B; Briggs, R; Cankocak, K; Chung, K; Clarida, W; Debbins, P; Duru, F; Ingram, F D; Lae, C K; McCliment, E; Merlo, J P; Mestvirishvili, A; Miller, M J; Moeller, A; Nachtman, J; Newsom, C R; Norbeck, E; Olson, J; Onel, Y; Ozok, F; Parsons, J; Schmidt, I; Sen, S; Wetzel, J; Yetkin, T; Yi, K; Barnett, B A; Blumenfeld, B; Bonato, A; Chien, C Y; Fehling, D; Giurgiu, G; Gritsan, A V; Guo, Z J; Maksimovic, P; Rappoccio, S; Swartz, M; Tran, N V; Zhang, Y; Baringer, P; Bean, A; Grachov, O; Murray, M; Radicci, V; Sanders, S; Wood, J S; Zhukova, V; Bandurin, D; Bolton, T; Kaadze, K; Liu, A; Maravin, Y; Onoprienko, D; Svintradze, I; Wan, Z; Gronberg, J; Hollar, J; Lange, D; Wright, D; Baden, D; Bard, R; Boutemeur, M; Eno, S C; Ferencek, D; Hadley, N J; Kellogg, R G; Kirn, M; Kunori, S; Rossato, K; Rumerio, P; Santanastasio, F; Skuja, A; Temple, J; Tonjes, M B; Tonwar, S C; Toole, T; Twedt, E; Alver, B; Bauer, G; Bendavid, J; Busza, W; Butz, E; Cali, I A; Chan, M; D'Enterria, D; Everaerts, P; Gomez Ceballos, G; Hahn, K A; Harris, P; Jaditz, S; Kim, Y; Klute, M; Lee, Y J; Li, W; Loizides, C; Ma, T; Miller, M; Nahn, S; Paus, C; Roland, C; Roland, G; Rudolph, M; Stephans, G; Sumorok, K; Sung, K; Vaurynovich, S; Wenger, E A; Wyslouch, B; Xie, S; Yilmaz, Y; Yoon, A S; Bailleux, D; Cooper, S I; Cushman, P; Dahmes, B; De Benedetti, A; Dolgopolov, A; Dudero, P R; Egeland, R; Franzoni, G; Haupt, J; Inyakin, A; Klapoetke, K; Kubota, Y; Mans, J; Mirman, N; Petyt, D; Rekovic, V; Rusack, R; Schroeder, M; Singovsky, A; Zhang, J; Cremaldi, L M; Godang, R; Kroeger, R; Perera, L; Rahmat, R; Sanders, D A; Sonnek, P; Summers, D; Bloom, K; Bockelman, B; Bose, S; Butt, J; Claes, D R; Dominguez, A; Eads, M; Keller, J; Kelly, T; Kravchenko, I; Lazo-Flores, J; Lundstedt, C; Malbouisson, H; Malik, S; Snow, G R; Baur, U; Iashvili, I; Kharchilava, A; Kumar, A; Smith, K; Strang, M; Alverson, G; Barberis, E; Boeriu, O; Eulisse, G; Govi, G; McCauley, T; Musienko, Y; Muzaffar, S; Osborne, I; Paul, T; Reucroft, S; Swain, J; Taylor, L; Tuura, L; Anastassov, A; Gobbi, B; Kubik, A; Ofierzynski, R A; Pozdnyakov, A; Schmitt, M; Stoynev, S; Velasco, M; Won, S; Antonelli, L; Berry, D; Hildreth, M; Jessop, C; Karmgard, D J; Kolberg, T; Lannon, K; Lynch, S; Marinelli, N; Morse, D M; Ruchti, R; Slaunwhite, J; Warchol, J; Wayne, M; Bylsma, B; Durkin, L S; Gilmore, J; Gu, J; Killewald, P; Ling, T Y; Williams, G; Adam, N; Berry, E; Elmer, P; Garmash, A; Gerbaudo, D; Halyo, V; Hunt, A; Jones, J; Laird, E; Marlow, D; Medvedeva, T; Mooney, M; Olsen, J; Piroué, P; Stickland, D; Tully, C; Werner, J S; Wildish, T; Xie, Z; Zuranski, A; Acosta, J G; Bonnett Del Alamo, M; Huang, X T; Lopez, A; Mendez, H; Oliveros, S; Ramirez Vargas, J E; Santacruz, N; Zatzerklyany, A; Alagoz, E; Antillon, E; Barnes, V E; Bolla, G; Bortoletto, D; Everett, A; Garfinkel, A F; Gecse, Z; Gutay, L; Ippolito, N; Jones, M; Koybasi, O; Laasanen, A T; Leonardo, N; Liu, C; Maroussov, V; Merkel, P; Miller, D H; Neumeister, N; Sedov, A; Shipsey, I; Yoo, H D; Zheng, Y; Jindal, P; Parashar, N; Cuplov, V; Ecklund, K M; Geurts, F J M; Liu, J H; Maronde, D; Matveev, M; Padley, B P; Redjimi, R; Roberts, J; Sabbatini, L; Tumanov, A; Betchart, B; Bodek, A; Budd, H; Chung, Y S; de Barbaro, P; Demina, R; Flacher, H; Gotra, Y; Harel, A; Korjenevski, S; Miner, D C; Orbaker, D; Petrillo, G; Vishnevskiy, D; Zielinski, M; Bhatti, A; Demortier, L; Goulianos, K; Hatakeyama, K; Lungu, G; Mesropian, C; Yan, M; Atramentov, O; Bartz, E; Gershtein, Y; Halkiadakis, E; Hits, D; Lath, A; Rose, K; Schnetzer, S; Somalwar, S; Stone, R; Thomas, S; Watts, T L; Cerizza, G; Hollingsworth, M; Spanier, S; Yang, Z C; York, A; Asaadi, J; Aurisano, A; Eusebi, R; Golyash, A; Gurrola, A; Kamon, T; Nguyen, C N; Pivarski, J; Safonov, A; Sengupta, S; Toback, D; Weinberger, M; Akchurin, N; Berntzon, L; Gumus, K; Jeong, C; Kim, H; Lee, S W; Popescu, S; Roh, Y; Sill, A; Volobouev, I; Washington, E; Wigmans, R; Yazgan, E; Engh, D; Florez, C; Johns, W; Pathak, S; Sheldon, P; Andelin, D; Arenton, M W; Balazs, M; Boutle, S; Buehler, M; Conetti, S; Cox, B; Hirosky, R; Ledovskoy, A; Neu, C; Phillips II, D; Ronquest, M; Yohay, R; Gollapinni, S; Gunthoti, K; Harr, R; Karchin, P E; Mattson, M; Sakharov, A; Anderson, M; Bachtis, M; Bellinger, J N; Carlsmith, D; Crotty, I; Dasu, S; Dutta, S; Efron, J; Feyzi, F; Flood, K; Gray, L; Grogg, K S; Grothe, M; Hall-Wilton, R; Jaworski, M; Klabbers, P; Klukas, J; Lanaro, A; Lazaridis, C; Leonard, J; Loveless, R; Magrans de Abril, M; Mohapatra, A; Ott, G; Polese, G; Reeder, D; Savin, A; Smith, W H; Sourkov, A; Swanson, J; Weinberg, M; Wenman, D; Wensveen, M; White, A

    2010-01-01

    The CMS detector is designed around a large 4 T superconducting solenoid, enclosed in a 12000-tonne steel return yoke. A detailed map of the magnetic field is required for the accurate simulation and reconstruction of physics events in the CMS detector, not only in the inner tracking region inside the solenoid but also in the large and complex structure of the steel yoke, which is instrumented with muon chambers. Using a large sample of cosmic muon events collected by CMS in 2008, the field in the steel of the barrel yoke has been determined with a precision of 3 to 8% depending on the location.

  19. "Person in the barrel" syndrome: Unusual heralding presentation of squamous cell carcinoma of the lung

    Directory of Open Access Journals (Sweden)

    Rajesh Verma

    2016-01-01

    Full Text Available Paraneoplastic neurological syndromes (PNS are rare and relatively unusual in day to day clinical practice. Occasionally, PNS may be the heralding manifestation of the malignancy. Paraneoplastic syndromes are most commonly associated with small cell lung carcinoma and are rarely seen with non small cell lung carcinoma. In this case, we report a non-smoker, middle aged lady, who presented with "person in the barrel" syndrome due to myelo radiculoplexopathy as the first clinical manifestation of squamous cell carcinoma of the lung.

  20. Precise mapping of the magnetic field in the CMS barrel yoke using cosmic rays

    Energy Technology Data Exchange (ETDEWEB)

    Chatrchyan, S. [Yerevan Physics Institute (Aremenia); et al.,

    2010-03-01

    The CMS detector is designed around a large 4 T superconducting solenoid, enclosed in a 12000-tonne steel return yoke. A detailed map of the magnetic field is required for the accurate simulation and reconstruction of physics events in the CMS detector, not only in the inner tracking region inside the solenoid but also in the large and complex structure of the steel yoke, which is instrumented with muon chambers. Using a large sample of cosmic muon events collected by CMS in 2008, the field in the steel of the barrel yoke has been determined with a precision of 3 to 8% depending on the location.

  1. Correlations decrease with propagation of spiking activity in the mouse barrel cortex

    Directory of Open Access Journals (Sweden)

    Gayathri Nattar Ranganathan

    2011-05-01

    Full Text Available Propagation of suprathreshold spiking activity through neuronal populations is important for the function of the central nervous system. Neural correlations have an impact on cortical function particularly on the signaling of information and propagation of spiking activity. Therefore we measured the change in correlations as suprathreshold spiking activity propagated between recurrent neuronal networks of the mammalian cerebral cortex. Using optical methods we recorded spiking activity from large samples of neurons from two neural populations simultaneously. The results indicate that correlations decreased as spiking activity propagated from layer 4 to layer 2/3 in the rodent barrel cortex.

  2. Vitamin D analog EB1089 could repair the defective bone marrow-derived mesenchymal stromal cells in patients with systemic lupus erythematosus.

    Science.gov (United States)

    Xu, Jing-Jing; Sun, Yan-Bin; Zhang, Xiao-Li; Wang, Xiao-Fei

    2015-01-01

    Systemic lupus erythematosus (SLE) involves multiple factors, which result in the breakdown of self-tolerance and development of autoimmunity with organ damage. Bone marrow mesenchymal stem cells (BMMSCs) from the patients with SLE showed an impaired proliferative capacity compared with that from normal controls. In this study, we isolated BMMSCs from the patients with SLE and found that Vitamin D analog EB1089 could induce BMMSCs proliferation and mineralization deposition. Furthermore, we found that the expression of p-Smad 1/5/8 was promoted in BMMSCs with EB1089 treatment. In conclusion, our results support the notion that EB1089 promoted proliferation and osteogenic differentiation of BMMSCs by Smad 1/5/8 signaling pathway.

  3. Differential skeletal responses of hindlimb unloaded rats on a vitamin D-deficient diet to 1,25-dihydroxyvitamin D3 and its analog, seocalcitol (EB1089)

    Science.gov (United States)

    Narayanan, Ramesh; Allen, Matthew R.; Gaddy, Dana; Bloomfield, Susan A.; Smith, Carolyn L.; Weigel, Nancy L.

    2004-01-01

    Conditions of disuse in bed rest patients, as well as microgravity experienced by astronauts are accompanied by reduced mechanical loading, reduced calcium absorption, and lower serum levels of 1,25(OH)2D3 (1,25-D), the active metabolite of vitamin D, all contributing to bone loss. To determine whether 1,25-D or a less calcemic analog, Seocalcitol or EB1089 (1 alpha,25-dihydroxy-22,24-diene-24,26,27-trihomovitamin D3) can alleviate bone loss in a rat hindlimb unloading model of disuse osteopenia, mature male rats originally on a vitamin D replete diet containing 1.01% calcium were transferred to a vitamin D-deficient diet containing 0.48% calcium and then tail suspended and treated for 28 days with vehicle, 0.05 microg/kg 1,25-D, or 0.05 microg/kg EB1089. The vitamin D-deficient diet caused a substantial decrease in bone mineral density (-8%), which may be compounded by hindlimb unloading (-10%). Exogenous 1,25-D not only prevented the bone loss but also increased the bone mineral density to greater than the baseline level (+7%). EB1089 was less effective in preventing bone loss. Analysis of site and cell-specific effects of 1,25-D and EB1089 revealed that 1,25-D was more active than EB1089 in the intestine, the site of calcium absorption, and in inducing osteoclastogenesis and bone resorption whereas EB1089 was more effective in inducing osteoblast differentiation. These studies suggest that elevating circulating 1,25-D levels presumably increasing calcium absorption can counteract bone loss induced by disuse or microgravity with its associated reductions in circulating 1,25-D and decreased calcium absorption.

  4. Translocation boost protein-folding efficiency of double-barreled chaperonins.

    Science.gov (United States)

    Coluzza, Ivan; van der Vies, Saskia M; Frenkel, Daan

    2006-05-15

    Incorrect folding of proteins in living cells may lead to malfunctioning of the cell machinery. To prevent such cellular disasters from happening, all cells contain molecular chaperones that assist nonnative proteins in folding into the correct native structure. One of the most studied chaperone complexes is the GroEL-GroES complex. The GroEL part has a "double-barrel" structure, which consists of two cylindrical chambers joined at the bottom in a symmetrical fashion. The hydrophobic rim of one of the GroEL chambers captures nonnative proteins. The GroES part acts as a lid that temporarily closes the filled chamber during the folding process. Several capture-folding-release cycles are required before the nonnative protein reaches its native state. Here we report molecular simulations that suggest that translocation of the nonnative protein through the equatorial plane of the complex boosts the efficiency of the chaperonin action. If the target protein is correctly folded after translocation, it is released. However, if it is still nonnative, it is likely to remain trapped in the second chamber, which then closes to start a reverse translocation process. This shuttling back and forth continues until the protein is correctly folded. Our model provides a natural explanation for the prevalence of double-barreled chaperonins. Moreover, we argue that internal folding is both more efficient and safer than a scenario where partially refolded proteins escape from the complex before being recaptured.

  5. Insertion of the first half-barrel of the ATLAS electromagnetic calorimeter into its cryostat

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    The first cylinder of the ATLAS electromagnetic calorimeter barrel and the presampler have been inserted in the cryostat.The ATLAS electromagnetic calorimeter is intended to detect electrons, positrons and photons by measuring the energy they deposit on being absorbed. The cylinder of the calorimeter is in two halves, that will be sunk in a liquid-argon bath cooled to 90 kelvin (-180°C). Each half-barrel is 3.2 metres long, 53 cm thick and formed by assembling 16 modules. Each module is made up of alternate lead absorbers and electrodes pressed into 64 layers folded accordion-fashion. The presampler, set up inside the cylinder, is an integral part of the calorimeter system: It measures the energy lost by a particle before it reaches the calorimeter. To ensure an ultra-clean environment, a tent (visible here) was erected round the calorimeter and entry point to the cryostat. The detector and presampler, fitted together, could then be slid gradually into the cryostat like a drawer. To do so, the insertion team...

  6. Insertion of the first half-barrel of the ATLAS electromagnetic calorimeter into its cryostat

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    The first cylinder of the ATLAS electromagnetic calorimeter barrel and the presampler have been inserted in the cryostat. The ATLAS electromagnetic calorimeter is intended to detect electrons, positrons and photons by measuring the energy they deposit on being absorbed. The cylinder of the calorimeter is in two halves, that will be sunk in a liquid-argon bath cooled to 90 kelvin (-180°C). Each half-barrel is 3.2 metres long, 53 cm thick and formed by assembling 16 modules. Each module is made up of alternate lead absorbers and electrodes pressed into 64 layers folded accordion-fashion. The presampler, set up inside the cylinder, is an integral part of the calorimeter system: It measures the energy lost by a particle before it reaches the calorimeter. To ensure an ultra-clean environment, a tent was erected round the calorimeter and entry point to the cryostat. The detector and presampler, fitted together, could then be slid gradually into the cryostat like a drawer. To do so, the insertion team had to fine-t...

  7. Installation of the Liquid Argon Calorimater Barrel in the ATLAS Experimental Cavern

    CERN Multimedia

    Vandoni, G.

    On the 27th of October, the Liquid Argon Barrel cryostat was transported from Building 180 to point 1. The next day, the Barrel was lowered into the cavern, and was placed on jacks close to its final position inside the completed lower half of the Tile calorimeter. After a day of precise adjustment, it was resting within a few millimetres of its nominal final position, waiting for the upper half of the Tile calorimeter to be installed. Tight requests had been issued by the Liquid Argon collaboration for the whole transport. It was foreseen that the cryostat should not see any acceleration larger than 0.15g along its axis, 0.08g transversally and 0.3g in the vertical direction. In addition, no acceleration higher than 0.03g (or even 0.003g for permanent oscillation) would be allowed at 20Hz, to avoid the risk of damaging the absorbers at this spontaneous vibration frequency. The difficulty would arise when coping these demands with the tortuous route, its slopes and curbs, vibration transmission from the engi...

  8. Shifts in coding properties and maintenance of information transmission during adaptation in barrel cortex.

    Directory of Open Access Journals (Sweden)

    Miguel Maravall

    2007-02-01

    Full Text Available Neuronal responses to ongoing stimulation in many systems change over time, or "adapt." Despite the ubiquity of adaptation, its effects on the stimulus information carried by neurons are often unknown. Here we examine how adaptation affects sensory coding in barrel cortex. We used spike-triggered covariance analysis of single-neuron responses to continuous, rapidly varying vibrissa motion stimuli, recorded in anesthetized rats. Changes in stimulus statistics induced spike rate adaptation over hundreds of milliseconds. Vibrissa motion encoding changed with adaptation as follows. In every neuron that showed rate adaptation, the input-output tuning function scaled with the changes in stimulus distribution, allowing the neurons to maintain the quantity of information conveyed about stimulus features. A single neuron that did not show rate adaptation also lacked input-output rescaling and did not maintain information across changes in stimulus statistics. Therefore, in barrel cortex, rate adaptation occurs on a slow timescale relative to the features driving spikes and is associated with gain rescaling matched to the stimulus distribution. Our results suggest that adaptation enhances tactile representations in primary somatosensory cortex, where they could directly influence perceptual decisions.

  9. A New Four-Barrel Pellet Injection System for the TJ-II Stellarator

    Energy Technology Data Exchange (ETDEWEB)

    Combs, Stephen Kirk [ORNL; Foust, Charles R [ORNL; McGill, James M [ORNL; Baylor, Larry R [ORNL; Caughman, John B [ORNL; Fehling, Dan T [ORNL; Harris, Jeffrey H [ORNL; Meitner, Steven J [ORNL; Rasmussen, David A [ORNL; McCarthy, K. J. [EURATOM-CIEMAT, Madrid, Spain; Chamorro, M. [Laboratory Nacional de Fusion, Madrid, Spain; Garcia, R. [Laboratory Nacional de Fusion, Madrid, Spain; Hildago, C. [Laboratory Nacional de Fusion, Madrid, Spain; Medrano, M. [Laboratory Nacional de Fusion, Madrid, Spain; Unamuno, R. [Laboratory Nacional de Fusion, Madrid, Spain

    2011-01-01

    A new pellet injection system for the TJ-II stellarator has been developed/constructed as part of a collaboration between the Oak Ridge National Laboratory (ORNL) and the Centro de Investigaciones Energ ticas, Medioambientales y Tecnol gicas (CIEMAT). ORNL is providing most of the injector hardware and instrumentation, the pellet diagnostics, and the pellet transport tubes; CIEMAT is responsible for the injector stand/interface to the stellarator, cryogenic refrigerator, vacuum pumps/ballast volumes, gas manifolds, remote operations, plasma diagnostics, and data acquisition. The pellet injector design is an upgraded version of that used for the ORNL injector installed on the Madison Symmetric Torus (MST). It is a four-barrel system equipped with a cryogenic refrigerator for in situ hydrogen pellet formation and a combined mechanical punch/propellant valve system for pellet acceleration (speeds ~100 to 1000 m/s). On TJ-II, it will be used as an active diagnostic and for fueling. To accommodate the plasma experiments planned for TJ-II, pellet sizes significantly smaller than those typically used for the MST application are required. The system will initially be equipped with four different pellet sizes, with the gun barrel bores ranging between ~0.5 to 1.0 mm. The new system is almost complete and is described briefly here, highlighting the new features added since the original MST injector was constructed. Also, the future installation on TJ-II is reviewed.

  10. The Common Cryogenic Test Facility for the Atlas Barrel and End-Cap Toroid Magnet

    CERN Document Server

    Delruelle, N; Junker, S; Passardi, Giorgio; Pengo, R; Pirotte, O

    2004-01-01

    The large ATLAS toroidal superconducting magnet made of the Barrel and two End-Caps needs extensive testing at the surface of the individual components prior to their final assembly into the underground cavern of LHC. A cryogenic test facility specifically designed for cooling sequentially the eight coils making the Barrel Toroid (BT) has been fully commissioned and is now ready for final acceptance of these magnets. This facility, originally designed for testing individually the 46 tons BT coils, will be upgraded to allow the acceptance tests of the two End-Caps, each of them having a 160 tons cold mass. The integrated system mainly comprises a 1.2 kW@4.5 K refrigerator, a 10 kW liquid-nitrogen precooler, two cryostats housing liquid helium centrifugal pumps of respectively 80 g/s and 600 g/s nominal flow and specific instrumentation to measure the thermal performances of the magnets. This paper describes the overall facility with particular emphasis to the cryogenic features adopted to match the specific re...

  11. The common cryogenic test facility for the ATLAS barrel and end-cap toroid magnets

    CERN Document Server

    Delruelle, N; Junker, S; Passardi, Giorgio; Pengo, R; Pirotte, O

    2004-01-01

    The large ATLAS toroidal superconducting magnet made of the Barrel and two End-Caps needs extensive testing at the surface of the individual components prior to their final assembly into the underground cavern of LHC. A cryogenic test facility specifically designed for cooling sequentially the eight coils making the Barrel Toroid (BT) has been fully commissioned and is now ready for final acceptance of these magnets. This facility, originally designed for testing individually the 46 tons BT coils, will be upgraded to allow the acceptance tests of the two End-Caps, each of them having 160 tons cold mass. The integrated system mainly comprises a 1.2 kW@4.5 K refrigerator, a 10 kW liquid-nitrogen precooler, two cryostats housing liquid helium centrifugal pumps of respectively 80 g/s and 600 g/s nominal flow and specific instrumentation to measure the thermal performances of the magnets. This paper describes the overall facility with particular emphasis to the cryogenic features adopted to match the specific requ...

  12. Design and Test of the Off-Detector Electronics for the CMS Barrel Muon Trigger

    CERN Document Server

    Guiducci, Luigi; Montanari, A; Odorici, F; Pellegrini, G; Torromeo, G; Travaglini, R

    2007-01-01

    Drift Tubes chambers are used in the CMS barrel for tagging the passage of high Pt muons generated in a LHC event and for triggering the CMS data read out. The Sector Collector (SC) system synchronizes the track segments built by trigger modules on the chambers and deliver them to reconstruction processors (Track Finder, TF) that assemble full muon tracks. Then, the Muon Sorter (MS) has to select the best four candidates in the barrel and to filter fake muons generated by the TF system redundancy. The hardware implementations of the Sector Collector and Muon Sorter systems satisfy radiation, I/O and fast timing constraints using several FPGA technologies. The hardware was tested with custom facilities, integrated with other trigger subsystems, and operated in a beam test. A test beam on a 40 MHz bunched beam validated the local trigger electronics and off-detector prototype cards and the synchronization tools. The CMS Magnet Test and Cosmic challenge in 2006 proved stable and reliable operation of the Drift T...

  13. Yucca Mountain, a high-level nuclear waste repository over a billion barrel oil field?

    International Nuclear Information System (INIS)

    New structural models and source rock data suggest that the proposed Yucca Mountain, Nevada, high-level nuclear waste repository lies in the Central Nevada thrust belt. The Central Nevada thrust belt could contain billion-barrel oil fields. The Central Nevada thrust belt coincides with an organic richness fairway and a maturation fairway of Mississippian source rocks that have already produced more than 25 million barrels of oil. Giant thrust-related structures along the thrust belt have yet to be tested. However, new work in the Tempahute Range, which lies between Yucca Mountain and the prolific Grant Canyon field, confirms the thrust belt concept and sheds light on source and reservoir rock quality and thrust belt geometry. Klippen of overmature Mississippian rocks are distinct on maturation maps such as the Diamond Range klippe in central Nevada. Thrust trends suggest that the Eleana Range near Yucca Mountain may be another klippe of overmature rocks over Mississippian source rocks in the oil window. There is a strong possibility that the subthrust source rocks may have generated large quantities of hydrocarbons that may be trapped in large thrust features beneath Yucca Mountain

  14. The Muon Spectrometer Barrel Level-1 Trigger of the ATLAS Experiment at LHC

    CERN Document Server

    Aloisio, A; Conventi, F; De Asmundis, R; Izzo, V; Migliaccio, A; Ciapetti, G; Di Mattia, A; Luci, C; Luminari, L; Nisati, A; Pastore, F; Petrolo, E; Vari, R; Veneziano, Stefano; Salamon, A

    2006-01-01

    The proton-proton beam crossing at the LHC accelerator at CERN will have a rate of 40 MHz at the project luminosity. The ATLAS Trigger System has been designed in three levels in order to select only interesting physics events reducing from that rate of 40 MHz to the foreseen storage rate of about 200 Hz. The First Level reduces the output rate to about 100 kHz. The ATLAS Muon Spectrometer has been designed to perform stand-alone triggering and measurement of muon transverse momentum up to 1 TeV/c with good resolution (from 3% at 10 GeV/c up to 10% at 1 TeV/c). In the Barrel region of the Muon Spectrometer the Level-1 trigger is given by means of three layers of Resistive Plate Chamber detectors (RPC): a gaseous detector working in avalanche mode composed by two plates of high-resistivity bakelite and two orthogonal planes of read-out strips. The logic of the Level-1 barrel muon trigger is based on the search of patterns of RPC hits in the three layers consistent with a high transverse momentum muon track ori...

  15. Design of Variable Width Barrel Shifter for High Speed Processor Architecture

    Directory of Open Access Journals (Sweden)

    Rajeev Kumar

    2012-04-01

    Full Text Available Microprocessor is the brain of the computer. It works as the Central Processing Unit of the computer. It contains Arithmetic Logical Unit (ALU that performs the arithmetic operations such as Addition, Subtraction, Multiplication and Division. It also performs the Logical operations such as AND, NAND, OR, NOR, EXOR, EXNOR and NOT. It also contains register file to store the operand in load/store instructions in RISC Processor Architecture. Control Unit genetares the control signals that synchronize the operation of the processor which tells the microarchitecture which operation is done at which time. Now during the multiplication partial product is shifted and added. So shifter is an important part of the processor architecture. Barrel Shifter is an important combinational logic block. It was incorporated in 386 processor and is also used in microcontroller design. Intel has since moved to software implemented shifters in the Pentium 4 Processor Architecture but AMD still uses it. Here the design of the variable width barrel shifter is presented in which we can shift 4bit, 8bit, 16bit, and 32bit and maximum 64bit partial product during multiplication. Functionality is check using Modelsim 6.4a.Now to generate the gate level netlist Xilinx ISE 9.2i is used.

  16. Mechanical assisted electroless barrel-plating Ni-P coatings on magnesium alloy

    Institute of Scientific and Technical Information of China (English)

    Zhaoxia PING; Juntao YUAN; Yedong HE; Xiaogang LI

    2009-01-01

    A mechanically assisted electroless barrel-plating Ni-P was carried out in a rolling drum containing Mg alloy specimens and ceramic balls, which was submerged in a bath containing electroless plating solution. It is demonstrated that the Ni-P coatings deposited by this novel technique have a crystallized Ni-P solid solution structure,showing fine-grains, higher hardness, and higher corrosion resistance compared with the conventional electroless plated amorphous Ni-P coatings. After heat treatment at 400 ~C for 1 h, the structure of such Ni-P coatings were transformed to a structure with Ni-Ni3P double phases, and cracks in these coatings could not-be observed,whereas cracks appeared seriously in the conventional electroless plated Ni-P coating after same heat treatment. Therefore, both hardness and corrosion resistance of these Ni-P coatings can be improved further by heat treatment. All of these beneficial effects can be attributed to the role of mechanical attrition during the mechanically assisted electroless barrel-plating process.

  17. A case of adenocarcinoma occurred at site of radiated double-barrel sigmoid colostomy

    International Nuclear Information System (INIS)

    A 60-year-old female developed an adenocarcinoma at the site of double-barrel sigmoid colostomy. She underwent a total hysterectomy and the subsequent radiation therapy due to carcinoma uteri when she was 34 years old. She had rectal stenosis one year later and underwent sigmoid colostomy. She had been healthy thereafter, however, when she was 58 years old, she noticed an elevated lesion at the site of colostomy. Biopsy revealed well-differentiated adenocarcinoma, so surgery was recommended but she refused it. Two years later, the entire stoma became a carcinoma, which directly invaded the abdominal wall on MRI images. A bow-shaped skin incision was made and en bloc resection of the tumor, colostomy and the surrounding tissues was performed. Finally, descending colostomy in the left upper quadrant of the abdomen was reconstructed. Primary adenocarcinoma occurring at a double-barrel colostomy is very rare, and such a case may never have been reported, although there were some reports of carcinoma occurring at an end colostomy. Since the site of the present carcinoma was radiated, the radiation may contribute to this carcinogenesis, suspecting its late effect. Our surgical procedure enabled simultaneously operation of combined resection and intraabdominal manipulation, and the reconstruction site of the stoma was easily selected. (author)

  18. Thalamic network oscillations synchronize ontogenetic columns in the newborn rat barrel cortex.

    Science.gov (United States)

    Yang, Jenq-Wei; An, Shuming; Sun, Jyh-Jang; Reyes-Puerta, Vicente; Kindler, Jennifer; Berger, Thomas; Kilb, Werner; Luhmann, Heiko J

    2013-06-01

    Neocortical areas are organized in columns, which form the basic structural and functional modules of intracortical information processing. Using voltage-sensitive dye imaging and simultaneous multi-channel extracellular recordings in the barrel cortex of newborn rats in vivo, we found that spontaneously occurring and whisker stimulation-induced gamma bursts followed by longer lasting spindle bursts were topographically organized in functional cortical columns already at the day of birth. Gamma bursts synchronized a cortical network of 300-400 µm in diameter and were coherent with gamma activity recorded simultaneously in the thalamic ventral posterior medial (VPM) nucleus. Cortical gamma bursts could be elicited by focal electrical stimulation of the VPM. Whisker stimulation-induced spindle and gamma bursts and the majority of spontaneously occurring events were profoundly reduced by the local inactivation of the VPM, indicating that the thalamus is important to generate these activity patterns. Furthermore, inactivation of the barrel cortex with lidocaine reduced the gamma activity in the thalamus, suggesting that a cortico-thalamic feedback loop modulates this early thalamic network activity.

  19. The in vivo pharmacokinetics study of anti-ProGRP(31-98) monoclonal antibody E-B5

    International Nuclear Information System (INIS)

    Objective: Progastrin-releasing peptide(31-98) (ProGRP(31-98) is a specific tumor marker in patients with small cell lung cancer (SCLC). E-B5 antibody against ProGRP(31-98) was produced by China Institute for Radiation Protection. The aim of this study was to explore the 131I labeling methods, stability, immunological activity and biological distribution pattern of E-B5 antibody against ProGRP(31-98). Methods: Chloramine-T method was used for 131I labeling E-B5 antibody. Labeling efficiency, radiochemical purity and stability were estimated by using paper chromatography method. Immunological activity of 131I-E-B5 was detected with cell conjugation assay. After healthy Kunming mice were injected with 131I-E-B5 antibody through tail veil, the biodistribution and pharmacokinetics of 131l-E-B5 antibody in healthy Kunming mice were studied. Continuous images of the nude mice beating SCLC were carried out at different time points after injection of 131I-E-B5 antibody. Continuous variables were expressed as x-bar ± s and compared by t-test with SPSS 13.0 software. Results: The labeling efficiency and radiochemical purity of 131I-E-B5were 90.8%, 99.28%, respectively. The radiochemical purity still maintained above 70% after incubation in water bath at 37 degree C for 24 h. After incubation with healthy serum for 24 h, the radiochemical purity still reached 68.1%. The immunobinding ratios were 71.6% and 33.2% for NCI-H446 cells and A549 cells respectively. The in vivo distribution and elimination of 131I-E-B5 antibody were consistent with a first-order and two-compartment model, t1/2α =0.2 h, t1/2β = 8.35 h. The metabolism of 131I-E-B5 antibody mainly depended on liver and kidney and with rapid elimination in blood. Conclusions: 131I-E-B5 antibody not only has high labeling efficiency and radiochemical purity, but also has good stability and keeps good immunological activity. 131I-E-B5 is a promising agent of radioimmunoimaging and radioimmunotherapy of SCLC. (authors

  20. Upgrade of the LHCb ECAL monitoring system

    CERN Document Server

    Rabusov, Andrey

    2014-01-01

    During the LHCb running in 2011 and 2012 it was found that the precision of PMT gain monitoring with LED system is affected by radiation damage of the long light guides transporting LED light to calorimeter cells. It was decided to replace in 2014 the present light guides to new ones that should be made of radiation tolerant quartz fibers. After the replacement, the system requires full tuning. It includes adjustment of the LED flash agnitudes and delays, and, after that, adjustment of the PIN diode system. My work was the following: to adjust the PIN signal amplitudes. This included a rough equalization of the amplitudes of signal from the 4 or 2 LEDs served by each PIN diode (achieved by mechanical adjustment of positions of corresponding fibers with respect to the PIN), and then reducing the PIN signal amplitude to the middle of the ADC range when necessary (total of 40 resistive attenuators were produced for this); to find timing corrections for ADCs digitizing the PIN signals; perform a PMT gain measure...

  1. ECALS: loading studies interim report July 2013

    Science.gov (United States)

    Klymus, Katy E.; Richter, Catherine A.; Chapman, Duane C.; Paukert, Craig P.

    2013-01-01

    Since the initial detection of Asian carp moving up the Mississippi Basin, the potential for invasion of the Great Lakes by Silver Carp and Bighead Carp has been a major concern to stakeholders. To combat this problem, sampling for environmental DNA (eDNA) is used to monitor the waterways near Lake Michigan. This monitoring area includes the Chicago Area Waterways System (CAWS) and the Des Plaines River. By sampling waters that may be inhabited by Asian carp, the extraction and amplification of carp DNA from the collected cellular debris is possible. This technique has been successfully used in several other contexts (Ficetola et al., 2008; Foote et al., 2008) and is believed to be a highly sensitive method for species detection (Dejean et al., 2012). Compared to traditional methods for surveying aquatic invasive species (fishing, rotenone application, and electrofishing), the increased sensitivity of this method could be a valuable asset. Early detection could lead to a more rapid response to the threat of a Great Lakes invasion by Asian carp.

  2. Hamamatsu APD for CMS ECAL Quality insurance

    CERN Document Server

    Bailleux, D; Deiters, K; Egeland, R; Gilbert, B; Grahl, J; Ingram, Q; Kuznetsov, A; Lester, E; Musienko, Y; Renker, D; Reucroft, S; Rusack, R W; Sakhelashvili, T M; Singovsky, A V; Swain, J D

    2004-01-01

    The Hamamatsu Photonics S8148 large area Avalanche Photo Diodes (APD) were designed for the crystal electromagnetic calorimeter of the CMS setup at LHC in a close collaboration of Hamamatsu Photonics and CMS APD group (PSI, Northeastern University and University of Minnesota). All essential parameters of these devices are controlled by the producer and are fairly stable during the mass production, except the radiation hardness. To insure 99.9% reliability of APDs in the radiation hard environment of LHC, the CMS APD group had to invent a dedicated screening procedure. The details of this procedure and some results of the screening are discussed.

  3. The Effects of CO2 Injection and Barrel Temperatures on the Physiochemical and Antioxidant Properties of Extruded Cereals

    Science.gov (United States)

    Thin, Thazin; Myat, Lin; Ryu, Gi-Hyung

    2016-01-01

    The effects of CO2 injection and barrel temperatures on the physiochemical and antioxidant properties of extruded cereals (sorghum, barley, oats, and millet) were studied. Extrusion was carried out using a twin-screw extruder at different barrel temperatures (80, 110, and 140°C), CO2 injection (0 and 500 mL/min), screw speed of 200 rpm, and moisture content of 25%. Extrusion significantly increased the total flavonoid content (TFC) of extruded oats, and β-glucan and protein digestibility (PD) of extruded barley and oats. In contrast, there were significant reductions in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, PD of extruded sorghum and millet, as well as resistant starch (RS) of extruded sorghum and barley, and total phenolic content (TPC) of all extrudates, except extruded millet. At a barrel temperature of 140°C, TPC in extruded barley was significantly increased, and there was also an increase in DPPH and PD in extruded millet with or without CO2 injection. In contrast, at a barrel temperature of 140°C, the TPC of extruded sorghum decreased, TFC of extruded oats decreased, and at a barrel temperature of 110°C, PD of extruded sorghum without CO2 decreased. Some physical properties [expansion ratio (ER), specific length, piece density, color, and water absorption index] of the extrudates were significantly affected by the increase in barrel temperature. The CO2 injection significantly affected some physical properties (ER, specific length, piece density, water solubility index, and water absorption index), TPC, DPPH, β-glucan, and PD. In conclusion, extruded barley and millet had higher potential for making value added cereal-based foods than the other cereals. PMID:27752504

  4. Comparative observation of protective effects of earplug and barrel on auditory organs of guinea pigs exposed to experimental blast underpressure

    Institute of Scientific and Technical Information of China (English)

    LI Chao-jun; ZHU Pei-fang; LIU Zhao-hua; WANG Zheng-guo; YANG Cheng; CHEN Hai-bin; NING Xin; ZHOU Ji-hong; Chen Jian

    2006-01-01

    Objective: To explore the protective effects of earplug and barrel on auditory organs of guinea pigs exposed to experimental blast underpressure (BUP).Methods: The hearing thresholds of the guinea pigs were assessed with auditory brainstem responses (ABR).The traumatic levels of tympanic membrane and ossicular chain were observed under stereo-microscope. The rate of outer hair cells (OHCs) loss was analyzed using a light microscope. The changes of guinea pigs protected with barrel and earplug were compared with those of the control group without any protection.Results: An important ABR threshold shift of the guinea pigs without any protection was detected from 8h to 14d after being exposed to BUP with a peak ranging from -64.5kPa to -69.3kPa (P<0.01). The rate of perforation of tympanic membrane reached 87.5 % and that of total OHCs loss was 19.46% + 5.38% at 14d after exposure. The guinea pigs protected with barrel and earplug had lower ABR threshold and total OHCs loss rate compared with the animals without any protection (P < 0.01 ). All of the tympanic membrane and ossicular chain of the protected animals maintained their integrities.Meanwhile, the guinea pigs protected with the barrel had lower ABR threshold and total OHCs loss rate than those with earplug (P<0.01).Conclusions: The earplug and barrel have protective effects against BUP-induced trauma on auditory organs of the guinea pigs and the protective effects of barrel are better than those of earplug.

  5. DD-EbA: An algorithm for determining the number of neighbors in cost estimation by analogy using distance distributions

    CERN Document Server

    Kosti, Makrina Viola; Angelis, Lefteris

    2010-01-01

    Case Based Reasoning and particularly Estimation by Analogy, has been used in a number of problem-solving areas, such as cost estimation. Conventional methods, despite the lack of a sound criterion for choosing nearest projects, were based on estimation using a fixed and predetermined number of neighbors from the entire set of historical instances. This approach puts boundaries to the estimation ability of such algorithms, for they do not take into consideration that every project under estimation is unique and requires different handling. The notion of distributions of distances together with a distance metric for distributions help us to adapt the proposed method (we call it DD-EbA) each time to a specific case that is to be estimated without loosing in prediction power or computational cost. The results of this paper show that the proposed technique achieves the above idea in a very efficient way.

  6. External beam accelerated partial breast irradiation (EB-APBI yields favorable outcomes in patients with prior breast augmentation

    Directory of Open Access Journals (Sweden)

    Rachel Yi-Feng Lei

    2014-06-01

    Full Text Available Purpose: To report outcomes in breast cancer patients with prior breast augmentation treated with external beam accelerated partial breast irradiation (EB-APBI utilizing intensity modulated radiotherapy (IMRT or 3-dimensional conformal radiotherapy (3D-CRT, both with image-guided radiotherapy (IGRT.Methods and Materials: 16 stage 0/I breast cancer patients with previous elective bilateral augmentation were treated post-lumpectomy on institutional EB-APBI trials (01185132 and 01185145 on clinicaltrials.gov. Patients received 38.5 Gy in 10 fractions over 5 consecutive days. Breast/chest wall pain and cosmesis were rated by patient; cosmesis was additionally evaluated by physician per RTOG criteria.Results: The median follow-up from APBI completion was 18.0 months (range, 1.2-58.6. Little to no change in cosmesis or pain from baseline was reported. Cosmetic outcomes at last follow-up were judged by patients as excellent/good in 93.8% (15/16, and by physicians as excellent/good in 100% (16/16. Eight patients (50.0% reported no breast/chest wall pain, and the remaining 8 patients (50.0% reported mild pain. All patients remain disease free at last follow-up. The median ipsilateral breast, planning target volume (PTV, and implant volumes were 614 cc, 57 cc, and 333 cc. The median ratios of PTV/ipsilateral breast volume (implant excluded and PTV/total volume (implant included were 9% and 6%. Conclusions: These 16 breast cancer cases with prior bilateral breast augmentation treated with external beam APBI demonstrate favorable clinical outcomes. Further exploration of external beam APBI as a treatment option for this patient po

  7. Analysis of VIA and EbA in a River Bank Erosion Prone Area of Bangladesh Applying DPSIR Framework

    Directory of Open Access Journals (Sweden)

    Syed Hafizur Rahman

    2016-10-01

    Full Text Available This study aims to set up a comprehensive approach to the Vulnerability and Impact Assessment (VIA of river erosion and to suggest Ecosystem-based Adaptation (EbA practices. Based on the analysis of vulnerability using the Driver-Pressure-State-Impact-Response (DPSIR framework, this paper discusses some of the significant climatic (rainfall pattern, temperature, seasonal drift, cold wave and heat wave and non-climatic (river erosion, repetitive death of field crops and agrochemicals forces in the Kazipur Upazila (Sirajganj District—a river erosion-prone area of Bangladesh. Both primary (Key Informants Interview, Household Survey, and Focus Group Discussion and secondary (climatic, literature review data have been used in revealing the scenario of climatic stress. The analysis revealed a slightly increasing trend of mean annual temperature, and a decreasing trend of total annual rainfall from 1981 to 2015, which have been supported by people’s perception. This study found that river erosion, the increase of temperature and the late arrival of monsoon rain, excessive monsoon rainfall, high use of agrochemicals, and flow alterations are major drivers in the riverine ecosystem. These drivers are creating pressures on agricultural land, soil fertility, water availability and livelihood patterns of affected communities. Hence, floating bed cultivation, integrated pest management, use of cover crops, reforestation, the introduction of an agro-weather forecasting system, and a new variety of flood tolerant species have been suggested as potential EbA to cope with river bank erosion and to increase the capacity of the affected ecosystem.

  8. Development and test of a prototype for the PANDA barrel DIRC detector at FAIR

    Energy Technology Data Exchange (ETDEWEB)

    Kalicy, Grzegorz

    2014-07-01

    The PANDA experiment at FAIR will perform world class physics studies using high-intensity cooled antiproton beams with momenta between 1.5 and 15 GeV/c. A rich physics program requires very good particle identification (PID). Charged hadron PID for the barrel section of the target spectrometer has to cover the angular range of 22-140 and separate pions from kaons for momenta up to 3.5 GeV/c with a separation power of at least 3 standard deviations. The system that will provide it has to be thin and operate in a strong magnetic field. A ring imaging Cherenkov detector using the DIRC principle meets those requirements. The design of the PANDA Barrel DIRC is based on the successful BABAR DIRC counter with several important changes to improve the performance and optimize the costs. The design options are being studied in detailed Monte Carlo simulation, and implemented in increasingly complex system prototypes and tested in particle beams. Before building the full system prototypes the radiator bars and lenses are measured on the test benches. The performance of the DIRC prototype was quantified in terms of the single photon Cherenkov angle resolution and the photon yield. Results for two full system prototypes will be presented. The prototype in 2011 aimed at investigating the full size expansion volume. It was found that the resolution for this configuration is at the level of in good agreement with ray tracing simulation results. A more complex prototype, tested in 2012, provided the first experience with a compact fused silica prism expansion volume, a wide radiator plate, and several advanced lens options for the focusing system. The performance of the baseline configuration of the prototype with a standard lens and an air gap met the requirements for the PANDA PID for most of the polar angle range but failed at polar angles around 90 due to photon loss at the air gap. Measurements with a prototype high-refractive index compound lens without an air gap at a polar

  9. MANAGEMENT BOARD 11/06/07 (MB106)

    CERN Multimedia

    Progress and Schedule Three muon DTs had been commissioned underground using cosmics. The EB- insertion was complete. The first global run had taken place as planned. Difficulties had led to a 4 week delay in the installation of YB0 services which was on the critical path. Over 200k cosmic events had been recorded by the Tracker, operating at just below 0 degrees. About 3500 ECAL end-cap crystals had been delivered, and the schedule for the last delivery at the end of March 2008 had been agreed; this meant that the last end-cap Dee could not be installed before the end of June. The concerns with the schedule were the YB0 services installation, the ECAL end-caps schedule which had suffered from manpower being tied up by the Barrel motherboards replacement, the preshower schedule and that of the pixel detecxtor which should be ready for installation in January. There were no significant technical issues. Work must continue as fast and as safely as possible. A message had been received from the CERN Directo...

  10. Use of biogas biscuit meal EKPO-EB for agricultural biogas plant for substitution of energy crops utilization with organic waste

    Directory of Open Access Journals (Sweden)

    Chamrádová Kateřina

    2015-09-01

    Full Text Available A laboratory experiment of two-stage mesophilic, low-dry mass, anaerobic digestion was carried out, focused on verifying the benefit of processing the biscuit meal EKPO-EB instead of triticale silage Agostino (GPS and corn silage LG3266 in a regular batch for the agricultural biogas station in Pustějov. While anaerobic digestion of ensilages is largely difficult due to the content of lignocellulose, biscuit meal provides a high yield of biogas or methane, respectively, thanks to its high content of simple saccharides and lipids. When the original GPS (or the replacement EKPO-EB, respectively represented 0.81% of weight of the daily input mixture dose for the first stage, the rise in volumetric methane production was 20% which is significant. The biscuit meal EKPO-EB decomposes almost completely in the first stage. Later, when the EKPO-EB represented 1.63% of weight of the daily input mixture dose for the first stage, the rise in volumetric methane production was 54% in the first stage and 16% in the second stage.

  11. Monitoring serverů s operačním systémem FreeBSD, jeho aplikací a služeb

    OpenAIRE

    Čejka, Zdeněk

    2007-01-01

    V této práci na téma Monitoring serverů s operačním systémem FreeBSD, jeho aplikací a služeb bude provedo nastavení služeb Apache, MySQL, Courier-IMAP, Postfix a ProFTPd a jejich monitoring. Sledováby budou také čísti systému nezbytné k jeho chodu. Práce je rozdělěna do dvou částí: nastavení monitorovaných služeb a aplikací a samotného monitoringu. Nastavení služeb je členěno do kapitol. Každé službě je věnována jedna. V těchto kapitolách je zahrnuto jak nastavení službeb, tak jejich popis a ...

  12. The kinesin-13 KLP10A motor regulates oocyte spindle length and affects EB1 binding without altering microtubule growth rates

    Directory of Open Access Journals (Sweden)

    Kevin K. Do

    2014-06-01

    Full Text Available Kinesin-13 motors are unusual in that they do not walk along microtubules, but instead diffuse to the ends, where they remove tubulin dimers, regulating microtubule dynamics. Here we show that Drosophila kinesin-13 klp10A regulates oocyte meiosis I spindle length and is haplo-insufficient – KLP10A, reduced by RNAi or a loss-of-function P element insertion mutant, results in elongated and mispositioned oocyte spindles, and abnormal cortical microtubule asters and aggregates. KLP10A knockdown by RNAi does not significantly affect microtubule growth rates in oocyte spindles, but, unexpectedly, EB1 binding and unbinding are slowed, suggesting a previously unobserved role for kinesin-13 in mediating EB1 binding interactions with microtubules. Kinesin-13 may regulate spindle length both by disassembling subunits from microtubule ends and facilitating EB1 binding to plus ends. We also observe an increased number of paused microtubules in klp10A RNAi knockdown spindles, consistent with a reduced frequency of microtubule catastrophes. Overall, our findings indicate that reduced kinesin-13 decreases microtubule disassembly rates and affects EB1 interactions with microtubules, rather than altering microtubule growth rates, causing spindles to elongate and abnormal cortical microtubule asters and aggregates to form.

  13. Comparison of data with Monte Carlo simulations at the ATLAS barrel combined testbeam 2004

    Science.gov (United States)

    Speckmayer, P.

    2009-04-01

    The scheme adopted as baseline by ATLAS for the calibration of hadrons depends strongly on the quality of the description of the data by simulations. In 2004, the calorimeters of the ATLAS barrel region have been exposed to a testbeam in order to evaluate the energy response of pions for the energies ranging from 1 to 350 GeV. For the energy region from 3 to 9 GeV a data analysis with the full systematic uncertainty is available. The data has been compared extensively to GEANT4 simulations. Several combinations of physical models—the so called "physics lists"—are provided by the GEANT4 collaboration and have been evaluated. The best overall description of data is achieved with the physics list QGSP_BERT which describes the energy response of pions within a few percent. QGSP_BERT has been adopted by ATLAS for the simulation of the first data.

  14. Comparison of data with Monte Carlo simulations at the ATLAS barrel combined testbeam 2004

    CERN Document Server

    Speckmayer, P

    2009-01-01

    The scheme adopted as baseline by ATLAS for the calibration of hadrons depends strongly on the quality of the description of the data by simulations. In 2004, the calorimeters of the ATLAS barrel region have been exposed to a testbeam in order to evaluate the energy response of pions for the energies ranging from 1 to 350 GeV. For the energy region from 3 to 9 GeV a data analysis with the full systematic uncertainty is available. The data has been compared extensively to GEANT4 simulations. Several combinations of physical models—the so called "physics lists"—are provided by the GEANT4 collaboration and have been evaluated. The best overall description of data is achieved with the physics list QGSP_BERT which describes the energy response of pions within a few percent. QGSP_BERT has been adopted by ATLAS for the simulation of the first data.

  15. Twenty barrel in situ pipe gun type solid hydrogen pellet injector for the Large Helical Device.

    Science.gov (United States)

    Sakamoto, Ryuichi; Motojima, Gen; Hayashi, Hiromi; Inoue, Tomoyuki; Ito, Yasuhiko; Ogawa, Hideki; Takami, Shigeyuki; Yokota, Mitsuhiro; Yamada, Hiroshi

    2013-08-01

    A 20 barrel solid hydrogen pellet injector, which is able to inject 20 cylindrical pellets with a diameter and length of between 3.0 and 3.8 mm at the velocity of 1200 m/s, has been developed for the purpose of direct core fueling in LHD (Large Helical Device). The in situ pipe gun concept with the use of compact cryo-coolers enables stable operation as a fundamental facility in plasma experiments. The combination of the two types of pellet injection timing control modes, i.e., pre-programing mode and real-time control mode, allows the build-up and sustainment of high density plasma around the density limit. The pellet injector has demonstrated stable operation characteristics during the past three years of LHD experiments. PMID:24007062

  16. 时尚怪人Iris Barrel Apfel登上着装名人榜

    Institute of Scientific and Technical Information of China (English)

    Holly(编译)

    2008-01-01

    近日,《名利场》杂志评出了2008国际最佳着装名人榜,这个榜单里有我们耳熟能详的名流,却也隐藏着极品“异类”。位列第七的Iris Barrel Apfel就是最典型的一位,这位86岁的著名室内设计师用“超级圆形大眼镜+超级大项链+无数手镯+古董衣”的标志性形象,让时尚界牢牢铭记住她的形象,并佩服得五体投地。

  17. Experimental investigation of a cook-off temperature in a hot barrel

    Institute of Scientific and Technical Information of China (English)

    Amer HAMEED a; Mathew AZAVEDO b; Philip PITCHER b

    2014-01-01

    The experimental investigations of the effect of contact time/temperature on initiating the cook-off using 7.62 mm calibre cartridge cases (CC) were conducted previously. These cartridges were filled with commercial off-the-shelf (COTS) double based (DB) propellant (Bulls Eye) and were loaded in a hot chamber. The thermal explosion temperature is of great significance to both weapon designers and safety inspectors as it provides the operational limit and safe operating temperature. For CC under test, it was found that the cook-off temperatures of this propellant were encountered with the heat transfer profile of the simulated gun barrel between 151.4 ?C and 153.4 ?C, with a reaction occurring in less than 300 s after the round was chambered. Usefully, each experiment was found to be consistent and repeatable.

  18. Detailed Surface Analysis Of Incremental Centrifugal Barrel Polishing (CBP) Of Single-Crystal Niobium Samples

    Energy Technology Data Exchange (ETDEWEB)

    Palczewski, Ari D.; Tian, Hui; Trofimova, Olga; Reece, Charles E.

    2011-07-01

    We performed Centrifugal Barrel Polishing (CBP) on single crystal niobium samples/coupons housed in a stainless steel sample holder following the polishing recipe developed at Fermi Lab (FNAL) in 2011 \\cite{C. A. Cooper 2011}. Post CBP, the sample coupons were analyzed for surface roughness, crystal composition and structure, and particle contamination. Following the initial analysis each coupon was high pressure rinsed (HRP) and analyzed for the effectiveness of contamination removal. We were able to obtain the mirror like surface finish after the final stage of tumbling, although some defects and embedded particles remained. In addition, standard HPR appears to have little effect on removing embedded particles which remain after each tumbling step, although final polishing media removal was partially affected by standard/extended HPR.

  19. 溶盐桶改造%Reform of salt dissolving barrels

    Institute of Scientific and Technical Information of China (English)

    刘红星

    2015-01-01

    采用井矿盐制烧碱可降低生产成本,为满足使用井矿盐的要求,对一次盐水装置的溶盐桶进行了技术改造:进水管采用5根,增加折流槽和中心筒。%The production cost of caustic soda can be reduced by using mineral salt as raw material. Transformations were carried out on the salt dissolving barrel adopted in primary brine devices, including installing 5 water feeding pipes, adding a baffle tank and a center cylinder, in order to meet the require-ments of using mineral salt.

  20. Applications of the double-barreled data in whole-genome shotgun sequence assembly and analysis

    Institute of Scientific and Technical Information of China (English)

    HAN Yujun; WANG Jing; GU Xiaocheng; YU Jun; LI Songgang; NI Peixiang; L(U) Hong; YE Jia; HU Jianfei; CHEN Chen; HUANG Xiangang; CONG Lijuan; LI Guangyuan

    2005-01-01

    Double-barreled (DB) data have been widely used for the assembly of large genomes. Based on the experience of building the whole-genome working draft of Oryza sativa L.ssp. Indica, we present here the prevailing and improved uses of DB data in the assembly procedure and report on novel applications during the following data-mining processes such as acquiring precise insert fragment information of each clone across the genome, and a new kind of Iow-cost whole-genome microarray. With the increasing number of organisms being sequenced,we believe that DB data will play an important role both in other assembly procedures and infuture genomic studies.

  1. Experimental investigation of a cook-off temperature in a hot barrel

    Directory of Open Access Journals (Sweden)

    Amer Hameed

    2014-06-01

    Full Text Available The experimental investigations of the effect of contact time/temperature on initiating the cook-off using 7.62 mm calibre cartridge cases (CC were conducted previously. These cartridges were filled with commercial off-the-shelf (COTS double based (DB propellant (Bulls Eye and were loaded in a hot chamber. The thermal explosion temperature is of great significance to both weapon designers and safety inspectors as it provides the operational limit and safe operating temperature. For CC under test, it was found that the cook-off temperatures of this propellant were encountered with the heat transfer profile of the simulated gun barrel between 151.4 °C and 153.4 °C, with a reaction occurring in less than 300 s after the round was chambered. Usefully, each experiment was found to be consistent and repeatable.

  2. Dosimetry assessments for the reactor pressure vessel and core barrel in UK PWR plant

    Energy Technology Data Exchange (ETDEWEB)

    Thornton, D.A.; Allen, D.A.; Huggon, A.P.; Picton, D.J.; Robinson, A.T.; Steadman, R.J. [Serco, Rutherford House, Quedgeley, Gloucester, Gl2 4NF (United Kingdom); Seren, T.; Lipponen, M.; Kekki, T. [VTT, Technical Research Centre of Finland, Otakaari 3 K, P.O. BOX 1000, Espoo, FI-02044 (Finland)

    2011-07-01

    Specimens for the Sizewell B reactor pressure vessel (RPV) inservice steels surveillance program are irradiated inside eight capsules located within the reactor pressure vessel and loaded prior to commissioning. The periodic removal of these capsules and testing of their contents provides material properties data at intervals during the lifetime of the plant. Neutron activation measurements and radiation transport calculations play an essential role in assessing the neutron exposure of the specimens and RPV. Following the most recent withdrawal, seven capsules have now been removed covering nine cycles of reactor operation. This paper summarizes the dosimetry results of the Sizewell B surveillance program obtained to date. In addition to an overview of the calculational methodology it includes a review of the measurements. Finally, it describes an extension of the methodology to provide dosimetry recommendations for the core barrel and briefly discusses the results that were obtained. (authors)

  3. Material wear and failure mode analysis of breakfast cereal extruder barrels and screw elements

    Science.gov (United States)

    Mastio, Michael Joseph, Jr.

    2005-11-01

    Nearly seventy-five years ago, the single screw extruder was introduced as a means to produce metal products. Shortly after that, the extruder found its way into the plastics industry. Today much of the world's polymer industry utilizes extruders to produce items such as soda bottles, PVC piping, and toy figurines. Given the significant economical advantages of extruders over conventional batch flow systems, extruders have also migrated into the food industry. Food applications include the meat, pet food, and cereal industries to name just a few. Cereal manufacturers utilize extruders to produce various forms of Ready-to-Eat (RTE) cereals. These cereals are made from grains such as rice, oats, wheat, and corn. The food industry has been incorrectly viewed as an extruder application requiring only minimal energy control and performance capability. This misconception has resulted in very little research in the area of material wear and failure mode analysis of breakfast cereal extruders. Breakfast cereal extruder barrels and individual screw elements are subjected to the extreme pressures and temperatures required to shear and cook the cereal ingredients, resulting in excessive material wear and catastrophic failure of these components. Therefore, this project focuses on the material wear and failure mode analysis of breakfast cereal extruder barrels and screw elements, modeled as a Discrete Time Markov Chain (DTMC) process in which historical data is used to predict future failures. Such predictive analysis will yield cost savings opportunities by providing insight into extruder maintenance scheduling and interchangeability of screw elements. In this DTMC wear analysis, four states of wear are defined and a probability transition matrix is determined based upon 24,041 hours of operational data. This probability transition matrix is used to predict when an extruder component will move to the next state of wear and/or failure. This information can be used to determine

  4. Revisiting the oligomerization mechanism of Vibrio cholerae cytolysin, a beta-barrel pore-forming toxin.

    Science.gov (United States)

    Rai, Anand Kumar; Chattopadhyay, Kausik

    2016-06-01

    Vibrio cholerae cytolysin (VCC) is a membrane-damaging beta-barrel pore-forming toxin (beta-PFT). VCC causes permeabilization of the target membranes by forming transmembrane oligomeric beta-barrel pores. Oligomerization is a key step in the mode of action of any beta-PFT, including that of VCC. Earlier studies have identified some of the key residues in VCC that are directly involved in the generation of the inter-protomer contacts, thus playing critical roles in the oligomerization of the membrane-bound toxin. Analysis of the VCC oligomeric pore structure reveals a potential hydrogen-bond network that appears to connect the sidechain of an asparagine residue (Asn582; located within an inter-domain linker sequence) from one protomer to the backbone CO- and NH-groups of the neighbouring protomer, indirectly through water molecules at most of the inter-protomer interfaces. In the present study, we show that the mutation of Asn582Ala affects the oligomerization and the pore-forming activity of VCC in the membrane lipid bilayer of the synthetic lipid vesicles, while the replacement of Asn582Gln results into the restoration of the oligomeric pore-forming ability of the toxin. Using a number of truncated variants of VCC, having deletion in the C-terminal region of the toxin starting from the Asn582 residue or beyond, we also show that the presence of Asn582 is critically required for the oligomerization of the truncated form of the protein. PMID:27150630

  5. Developmental switch in neurovascular coupling in the immature rodent barrel cortex.

    Directory of Open Access Journals (Sweden)

    Christoph M Zehendner

    Full Text Available Neurovascular coupling (NVC in the adult central nervous system (CNS is a mechanism that provides regions of the brain with more oxygen and glucose upon increased levels of neural activation. Hemodynamic changes that go along with neural activation evoke a blood oxygen level-dependent (BOLD signal in functional magnetic resonance imaging (fMRI that can be used to study brain activity non-invasively. A correct correlation of the BOLD signal to neural activity is pivotal to understand this signal in neuronal development, health and disease. However, the function of NVC during development is largely unknown. The rodent whisker-to-barrel cortex is an experimentally well established model to study neurovascular interdependences. Using extracellular multi-electrode recordings and laser-Doppler-flowmetry (LDF we show in the murine barrel cortex of postnatal day 7 (P7 and P30 mice in vivo that NVC undergoes a physiological shift during the first month of life. In the mature CNS it is well accepted that cortical sensory processing results in a rise in regional cerebral blood flow (rCBF. We show in P7 animals that rCBF decreases during prolonged multi-whisker stimulation and goes along with multi unit activity (MUA fatigue. In contrast at P30, MUA remains stable during repetitive stimulation and is associated with an increase in rCBF. Further we characterize in both age groups the responses in NVC to single sensory stimuli. We suggest that the observed shift in NVC is an important process in cortical development that may be of high relevance for the correct interpretation of brain activity e.g. in fMRI studies of the immature central nervous system (CNS.

  6. 106例儿童EB病毒感染的临床分析%106 case of laboratory examinations and analysis to EB virus infection in children

    Institute of Scientific and Technical Information of China (English)

    陈波; 王峰; 郑瑞丰; 周彤

    2008-01-01

    Objective To study laboratory examinations of the EB virus infection in children. MethodsRetrospective analysis laboratory data of 106 cases of EB virus infection treated in our hospital in January 2005 to November 2007. Results WBC and lymphocyte ratio increased significantly in EB virus infection,some have increased platelet and mild anemia, often without CRP and erythrocyte sedimentation rate in-creused, devoted liver enzyme and myocardial enzyme common, LDH which increased the most common, fol-lowed by αHBDH, AST and ALT. Heterotypic lymphocyte did not reach 10 percent was also more common.Conclusion We should attach importance to the analysis of laboratory examination of EB virns in fection, inorder to get early dues to find EB virus infection%目的 分析儿童EB病毒感染实验室检查的临床特点.方法 回顾性分析我院2005年1月至2007年11月收治的EB病毒感染患儿106例的实验室检查资料.结果 EB病毒感染WBC及淋巴细胞比例常明显升高,部分有血小板升高及轻度贫血,CRP及血沉常无升高.肝酶及心肌酶升高常见,其中LDH最常见,其次为αHBDH、AST、ALT.外周血异常淋巴细胞未达到10%者也较常见.结论 要重视分析EB病毒的实验检查,以便找到早期诊断EB病毒感染的线索.

  7. TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein.

    Science.gov (United States)

    Desrosiers, Daniel C; Anand, Arvind; Luthra, Amit; Dunham-Ems, Star M; LeDoyt, Morgan; Cummings, Michael A D; Eshghi, Azad; Cameron, Caroline E; Cruz, Adriana R; Salazar, Juan C; Caimano, Melissa J; Radolf, Justin D

    2011-06-01

    Definitive identification of Treponema pallidum rare outer membrane proteins (OMPs) has long eluded researchers. TP0326, the sole protein in T. pallidum with sequence homology to a Gram-negative OMP, belongs to the BamA family of proteins essential for OM biogenesis. Structural modelling predicted that five polypeptide transport-associated (POTRA) domains comprise the N-terminus of TP0326, while the C-terminus forms an 18-stranded amphipathic β-barrel. Circular dichroism, heat modifiability by SDS-PAGE, Triton X-114 phase partitioning and liposome incorporation supported these topological predictions and confirmed that the β-barrel is responsible for the native protein's amphiphilicity. Expression analyses revealed that native TP0326 is expressed at low abundance, while a protease-surface accessibility assay confirmed surface exposure. Size-exclusion chromatography and blue native polyacrylamide gel electrophoresis revealed a modular Bam complex in T. pallidum larger than that of Escherichia coli. Non-orthologous ancillary factors and self-association of TP0326 via its β-barrel may both contribute to the Bam complex. T. pallidum-infected rabbits mount a vigorous antibody response to both POTRA and β-barrel portions of TP0326, whereas humans with secondary syphilis respond predominantly to POTRA. The syphilis spirochaete appears to have devised a stratagem for harnessing the Bam pathway while satisfying its need to limit surface antigenicity. PMID:21488980

  8. Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs

    Directory of Open Access Journals (Sweden)

    Zhang Guanjun

    2013-01-01

    Full Text Available Abstract Loss of a sensory input causes the hypersensitivity in other modalities. In addition to cross-modal plasticity, the sensory cortices without receiving inputs undergo the plastic changes. It is not clear how the different types of neurons and synapses in the sensory cortex coordinately change after input deficits in order to prevent loss of their functions and to be used for other modalities. We studied this subject in the barrel cortices from whiskers-trimmed mice vs. controls. After whisker trimming for a week, the intrinsic properties of pyramidal neurons and the transmission of excitatory synapses were upregulated in the barrel cortex, but inhibitory neurons and GABAergic synapses were downregulated. The morphological analyses indicated that the number of processes and spines in pyramidal neurons increased, whereas the processes of GABAergic neurons decreased in the barrel cortex. The upregulation of excitatory neurons and the downregulation of inhibitory neurons boost the activity of network neurons in the barrel cortex to be high levels, which prevent the loss of their functions and enhances their sensitivity to sensory inputs. These changes may prepare for attracting the innervations from sensory cortices and/or peripheral nerves for other modalities during cross-modal plasticity.

  9. Lock, Stock and Two Different Barrels: Comparing the Genetic Composition of Morphotypes of the Indo-Pacific Sponge

    NARCIS (Netherlands)

    Swierts, T.; Peijnenburg, K.T.C.A.; de Leeuw, C.; Cleary, D.F.R.; Hörnlein, C.; Setiawan, E.; Wörheide, G.; Erpenbeck, D.; de Voogd, N.J.

    2013-01-01

    The giant barrel sponge Xestospongia testudinaria is an ecologically important species that is widely distributed across the Indo-Pacific. Little is known, however, about the precise biogeographic distribution and the amount of morphological and genetic variation in this species. Here we provide the

  10. Research status of electromagnetic rail gun barrel structure%电磁轨道炮身管结构的研究概况

    Institute of Scientific and Technical Information of China (English)

    吕彦; 任泽宁; 钱学梅; 胡俊; 黄建文; 杨忠贤; 赵鸿雁

    2012-01-01

    电磁轨道炮身管工况特殊、结构复杂,开发轻质、高效的身管是电磁轨道炮走向实战应用的关键.从结构力学方面介绍电磁轨道炮管对材料和结构的要求,综述典型的轨道炮身管结构设计概况.归纳实战型轨道炮管结构设计的关键点.%Due to special working conditions and complex structure of electromagnetic rail gun barrel, the exploration of lightweight, efficient barrel becomes the key for actual cnmbal application of electromagnetic rail gun. Material and structural requirements of gun barrel are illustrated from the viewpoints of structural mechanics, typical barrel designs are reviewed, and the key points of actual combat barrel design are summarized.

  11. Resilience to disturbance despite limited dispersal and self-recruitment in tropical barrel sponges: implications for conservation and management.

    Directory of Open Access Journals (Sweden)

    James J Bell

    Full Text Available While estimates of connectivity are important for effective management, few such estimates are available for reef invertebrates other than for corals. Barrel sponges are one of the largest and most conspicuous members of the coral reef fauna across the Indo-Pacific and given their large size, longevity and ability to process large volumes of water, they have a major role in reef functioning. Here we used a panel of microsatellite markers to characterise the genetic structure of two barrel sponge species, Xestospongia testudinaria and a currently undescribed Xestospongia species. We sampled across seven populations in the Wakatobi Marine National Park, SE Sulawesi (Indonesia spanning a spatial scale of approximately 2 to 70 km, and present the first estimates of demographic connectivity for coral reef sponges. Genetic analyses showed high levels of genetic differentiation between all populations for both species, but contrasting patterns of genetic structuring for the two species. Autocorrelation analyses showed the likely dispersal distances of both species to be in the order of 60 and 140 m for Xestopongia sp. and Xestospongia testudinaria, respectively, which was supported by assignment tests that showed high levels of self-recruitment (>80%. We also found consistently high inbreeding coefficients across all populations for both species. Our study highlights the potential susceptibility of barrel sponges to environmental perturbations because they are generally long-lived, slow growing, have small population sizes and are likely to be reliant on self-recruitment. Surprisingly, despite these features we actually found the highest abundance of both barrel sponge species (although they were generally smaller at a site that has been severely impacted by humans over the last fifty years. This suggests that barrel sponges exhibit environmental adaptation to declining environmental quality and has important implications for the management and

  12. EB-PVD梯度热障涂层的制备及其热疲劳性能%DEVELOPMENT OF EB-PVD GRADIENT THERMAL BARRIER COATINGS AND THEIR THERMAL-FATIGUE BEHAVIORS

    Institute of Scientific and Technical Information of China (English)

    郭洪波; 宫声凯; 徐惠彬; 刘福顺

    2000-01-01

    采用EB-PVD的方法,连续蒸发按一定组分比混合的Al+Al2O3+ZrO2混合源,在Ni基高温合金基体上制备了一种新型结构的热障涂层.SEM和EDS的观察、分析表明,这种涂层实现了由金属粘结层向陶瓷顶层的微观结构的梯度过渡和化学成分的连续变化.涂层的基本结构为NiCoCrAlY/Ni3Al/Ni3Al+Al2O3/Al2O3/Al2O3+ZrO2/ZrO2.这种梯度热障涂层在1050℃的抗高温氧化性能优于传统的二层结构的热障涂层.经1050℃保温30 min,迅速冷却至室温的热循环测试300次后,涂层没有发生剥落,显示了良好的抗热震性能.

  13. Lipid bilayer-bound conformation of an integral membrane beta barrel protein by multidimensional MAS NMR

    Energy Technology Data Exchange (ETDEWEB)

    Eddy, Matthew T. [The Scripps Research Institute, Department of Integrative Structural and Computational Biology (United States); Su, Yongchao; Silvers, Robert; Andreas, Loren; Clark, Lindsay [Massachusetts Institute of Technology, Department of Chemistry (United States); Wagner, Gerhard [Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology (United States); Pintacuda, Guido; Emsley, Lyndon [Université de Lyon, Centre de RMN à Très Hauts Champs, Institut des Sciences Analytiques (CNRS, ENS Lyon, UCB Lyon 1) (France); Griffin, Robert G., E-mail: rgg@mit.edu [Massachusetts Institute of Technology, Department of Chemistry (United States)

    2015-04-15

    The human voltage dependent anion channel 1 (VDAC) is a 32 kDa β-barrel integral membrane protein that controls the transport of ions across the outer mitochondrial membrane. Despite the determination of VDAC solution and diffraction structures, a structural basis for the mechanism of its function is not yet fully understood. Biophysical studies suggest VDAC requires a lipid bilayer to achieve full function, motivating the need for atomic resolution structural information of VDAC in a membrane environment. Here we report an essential step toward that goal: extensive assignments of backbone and side chain resonances for VDAC in DMPC lipid bilayers via magic angle spinning nuclear magnetic resonance (MAS NMR). VDAC reconstituted into DMPC lipid bilayers spontaneously forms two-dimensional lipid crystals, showing remarkable spectral resolution (0.5–0.3 ppm for {sup 13}C line widths and <0.5 ppm {sup 15}N line widths at 750 MHz). In addition to the benefits of working in a lipid bilayer, several distinct advantages are observed with the lipid crystalline preparation. First, the strong signals and sharp line widths facilitated extensive NMR resonance assignments for an integral membrane β-barrel protein in lipid bilayers by MAS NMR. Second, a large number of residues in loop regions were readily observed and assigned, which can be challenging in detergent-solubilized membrane proteins where loop regions are often not detected due to line broadening from conformational exchange. Third, complete backbone and side chain chemical shift assignments could be obtained for the first 25 residues, which comprise the functionally important N-terminus. The reported assignments allow us to compare predicted torsion angles for VDAC prepared in DMPC 2D lipid crystals, DMPC liposomes, and LDAO-solubilized samples to address the possible effects of the membrane mimetic environment on the conformation of the protein. Concluding, we discuss the strengths and weaknesses of the

  14. Lipid bilayer-bound conformation of an integral membrane beta barrel protein by multidimensional MAS NMR

    International Nuclear Information System (INIS)

    The human voltage dependent anion channel 1 (VDAC) is a 32 kDa β-barrel integral membrane protein that controls the transport of ions across the outer mitochondrial membrane. Despite the determination of VDAC solution and diffraction structures, a structural basis for the mechanism of its function is not yet fully understood. Biophysical studies suggest VDAC requires a lipid bilayer to achieve full function, motivating the need for atomic resolution structural information of VDAC in a membrane environment. Here we report an essential step toward that goal: extensive assignments of backbone and side chain resonances for VDAC in DMPC lipid bilayers via magic angle spinning nuclear magnetic resonance (MAS NMR). VDAC reconstituted into DMPC lipid bilayers spontaneously forms two-dimensional lipid crystals, showing remarkable spectral resolution (0.5–0.3 ppm for 13C line widths and <0.5 ppm 15N line widths at 750 MHz). In addition to the benefits of working in a lipid bilayer, several distinct advantages are observed with the lipid crystalline preparation. First, the strong signals and sharp line widths facilitated extensive NMR resonance assignments for an integral membrane β-barrel protein in lipid bilayers by MAS NMR. Second, a large number of residues in loop regions were readily observed and assigned, which can be challenging in detergent-solubilized membrane proteins where loop regions are often not detected due to line broadening from conformational exchange. Third, complete backbone and side chain chemical shift assignments could be obtained for the first 25 residues, which comprise the functionally important N-terminus. The reported assignments allow us to compare predicted torsion angles for VDAC prepared in DMPC 2D lipid crystals, DMPC liposomes, and LDAO-solubilized samples to address the possible effects of the membrane mimetic environment on the conformation of the protein. Concluding, we discuss the strengths and weaknesses of the reported

  15. A full 3D model of fluid flow and heat transfer in an E.B. heated liquid metal bath

    Science.gov (United States)

    Matveichev, A.; Jardy, A.; Bellot, J. P.

    2016-07-01

    In order to study the dissolution of exogeneous inclusions in the liquid metal during processing of titanium alloys, a series of dipping experiments has been performed in an Electron Beam Melting laboratory furnace. Precise determination of the dissolution kinetics requires knowing and mastering the exact thermohydrodynamic behavior of the melt pool, which implies full 3D modeling of the process. To achieve this goal, one needs to describe momentum and heat transfer, phase change, as well as the development of flow turbulence in the liquid. EB power input, thermal radiation, heat loss through the cooling circuit, surface tension effects (i.e. Marangoni-induced flow) must also be addressed in the model. Therefore a new solver dealing with all these phenomena was implemented within OpenFOAM platform. Numerical results were compared with experimental data from actual Ti melting, showing a pretty good agreement. In the second stage, the immersion of a refractory sample rod in the liquid pool was simulated. Results of the simulations showed that the introduction of the sample slightly disturbs the flow field inside the bath. The amount of such disturbance depends on the exact location of the dipping.

  16. Evolution of photo-stimulated luminescence of EB-PVD/(Ni, Pt)Al thermal barrier coatings

    Energy Technology Data Exchange (ETDEWEB)

    Wen Mei [Department of Metallurgy and Materials Engineering, University of Connecticut, Storrs, CT 06269 (United States); Jordan, Eric H. [Department of Mechanical Engineering, University of Connecticut, Storrs, CT 06269 (United States)]. E-mail: jordan@engr.uconn.edu; Gell, Maurice [Department of Metallurgy and Materials Engineering, University of Connecticut, Storrs, CT 06269 (United States)

    2005-05-25

    Experiments are described which were designed to assess the suitability of photo-stimulated luminescence piezo-spectroscopy (PLPS) measurements as a basis for non-destructive inspection (NDI) and determination of life remaining of thermal barrier coatings (TBCs). Thermal cyclic tests were conducted on 7 wt.% Y{sub 2}O{sub 3} stabilized ZrO{sub 2} (YSZ) electron beam physical vapor deposited (EB-PVD)/(Ni, Pt)Al/CMSX-4 TBCs at two temperatures 1151 and 1121 deg. C. The evolution of PLPS spectral characteristics (peak frequency shift, peak width and area ratio of peaks) was studied as a function of thermal cycles. It was observed that the average thermally grown oxide (TGO) stress and its standard deviation, and the area ratio of peaks show systematic change with thermal cycling, indicating that these characteristics can be used for NDI and determination of life remaining. The average TGO stress increases initially and then decreases monotonically with thermal cycling. The rate of change in the stress can be related to specimen life: the shallower the slope, the higher the life. The peak area ratio also decreases monotonically with cycling. The average TGO stress changes in a systematic manner versus remaining life fraction independent of temperature. Remaining life predictions were made based on average stress versus life fraction, which resulted in life assessments within {+-}13% of actual values excluding one specimen with abnormal behavior.

  17. Klient virtuální čekárny pro poskytovatele služeb

    OpenAIRE

    Holcman, Jaroslav

    2016-01-01

    Cílem této práce je navrhnout a implementovat klientskou aplikaci s grafickým uživatelským rozhraním pro poskytovatele služeb v rámci projektu Virtuální čekárna. Grafické uživatelské rozhraní umožňuje poskytovateli pracovat s frontami zákazníků, objednávat zákazníky na určené termíny a celkově pracovat s daty, která jsou uložena na serveru. Uživatelské rozhraní je vytvořeno pomocí technologie WPF z .NET Frameworku od firmy Microsoft. Text této práce popisuje projekt Virtuální čekárny jako cel...

  18. A relay mechanism between EB1 and APC facilitate STIM1 puncta assembly at endoplasmic reticulum-plasma membrane junctions.

    Science.gov (United States)

    Asanov, Alexander; Sherry, Ryan; Sampieri, Alicia; Vaca, Luis

    2013-09-01

    The assembly of STIM1 protein puncta near endoplasmic reticulum-plasma membrane (ER-PM) junctions is required for optimal activation of store-operated channels (SOC). The mechanisms controlling the translocation of STIM1 puncta to ER-PM junctions remain largely unknown. In the present study, we have explored the role of the microtubule binding protein adenomatous polyposis coli (APC), on STIM1 puncta and store-operated calcium entry (SOCE). APC-depleted cells showed reduced STIM1 puncta near ER-PM junctions, instead puncta is found at the ER surrounding the cell nucleus. Reduced STIM1 puncta near ER-PM junctions in APC-depleted cells correlates with a strong inhibition of SOCE and diminished Orai whole-cell currents. Immunoprecipitation and confocal microscopy co-localization studies indicate that, upon depletion of the ER, STIM1 dissociates from EB1 and associates to APC. Deletion analysis identified an APC-binding domain in the carboxyl terminus of STIM1 (STIM1 650-685). These results together position APC as an important element in facilitating the translocation of STIM1 puncta near ER-PM junctions, which in turn is required for efficient SOCE and Orai activation upon depletion of the ER.

  19. The Study of Selected Properties of Ti EB PVD Coating Deposited Onto Inner Tube Surface at Low Temperature

    Directory of Open Access Journals (Sweden)

    Kottfer D.

    2016-03-01

    Full Text Available This study investigates the selected properties of the thin Ti coating applied by activated evaporation EB PVD technique. This technique was used for the deposition of Ti thin coating onto inner surface of OKhN3 MFA steel tubes. Deposition process was carried out at temperature 200°C. Conventional type of coatings - monolayer Ti - was analyzed by standard techniques for surface status and quality assessment - coating thickness, chemical composition by EDX analysis, adhesion, hardness, roughness, and growth direction of columns at room temperature. Ti monolayer achieved roughness Ra equal from 0.42 μm to 0.47 μm. The resulting hardness was from 2 GPa to 8.5 GPa depending on the sample location inside the vacuum chamber. Placing of the coated surface also affected the direction of grain growth of Ti coating columns. The angles α of grain growth were found to be from 40° to 60°. Angle α increased two to three times more than the incidence angle β (from 12° to 28° of evaporated Ti particles. Values of the adhesion measured along the Ti growth direction were mostly higher (up to 10% or the same as those measured perpendicular to it.

  20. Design of Portable Barrel-scrubbing Robot%便携式炮管擦洗机器人设计

    Institute of Scientific and Technical Information of China (English)

    陶卫军; 廖凯; 冯虎田; 钱林方

    2011-01-01

    Aiming at the existing problem that the inner barrel is hard to be cleaned, a new portable barrel-scrubbing robot is proposed and designed. For the requirement of scrubbing the inner barrel, the working principle and the scrubbing mode of this robot is determined. The main modules of the robot are designed and the control system is constructed. The robot's mechanical analysis for the course of scrubbing is done by the classical mechanics method, and the driving moment is obtained and calculated through the simulation. A prototype of the portable barrel-scrubbing robot is manufactured and the experiments of the robot's motion function are implemented. The experimental results show that the designed robot can perform the barrel-scrubbing work when the tilt angle of the barrel is up to 22° and the maximum speed of robot reaches 0. 75 m/min, and can meet the utilization requirement in the open country or on the scene of army exercises.%针对炮管内壁清洗难的现状,提出并设计了一种新型便携式炮管内壁擦洗机器人.针对炮管内壁擦洗要求,确定了机器人的工作原理与擦洗方式;对机器人的主要结构模块进行了设计,并搭建了机器人的控制系统;采用经典力学方法对机器人复合擦洗过程中的力学进行了分析,得到了其驱动力矩并进行了仿真计算;制作了便携式炮管内壁擦洗机器人样机,并进行了运动功能实验.实验结果表明,所设计的机器人能在炮管最大倾角为22°时进行擦洗工作,其最大直线运动速度能达到0.75 m/min,能满足在野外或演习现场使用要求.

  1. SDC muon barrel toroid 1/9.197 scale test model at SSC

    International Nuclear Information System (INIS)

    The purpose of the scale model for the muon barrel toroid (MBT) is to discover any problems in the preliminary design associated with the fabrication, assembly and installation. The information obtained from the model fabrication, assembly, installation, and testing processes will be used to evaluate the MBT preliminary design and to verify the finite element (FE) analysis. The final design of the MBT will take advantage of the experience gained from the test model to improve the design and engineering, fabrication methods, and assembly methods. The goals that are considered relevant to the test model include the following: Verify the in-plane and out-of-plane stiffness of the test model as predicted by the FE analysis. Verify the corner joint stiffness of the test model as predicted by the FE analysis. Verify the fabrication and assembly methods for the blocks, pins and keys on a small scale. Demonstrate the plate flattening scheme on a small scale. Insure that the preliminary design of the MBT can be assembled into the correct shape on a small scale. A magnetic measurement will be performed to record the field density inside an air gap. The main goal is to find out the field distribution for the test model due to geometry variation. The field measurements will also provide the information to verify the magnetic property of the steel material as well as the impact on the field distribution due to material variation

  2. The CERN cryogenic test facility for the ATLAS barrel toroid magnets

    CERN Document Server

    Haug, F; Delruelle, N; Orlic, J P; Passardi, Giorgio; Tischhauser, Johann

    2000-01-01

    The superconducting magnet system of the ATLAS detector will consist of a central solenoid, two end-cap toroidal magnets (ECT) and the barrel toroid magnet (BT) made of eight coils symmetrically placed around the central axis of the detector. The magnets will be tested individually in a 5000 m/sup 2/ experimental area prior to their final installation at an underground cavern of the LHC Collider. For the BT magnets, a dedicated cryogenic test facility has been designed which is currently under the construction and commissioning phase. A liquid nitrogen pre-cooling unit and a 1200 W@4.5K refrigerator will allow flexible operating conditions via a rather complex distribution and transfer line system. Flow of two-phase helium for cooling the coils is provided by centrifugal pumps immersed in a saturated liquid helium bath. The integration of the pumps in an existing cryostat required the adoption of novel mechanical solutions. Tests conducted permitted the validation of the technical design of the cryostat and i...

  3. The coincidence matrix ASIC of the level-1 muon barrel trigger of the ATLAS experiment

    CERN Document Server

    Bocci, V; Salamon, A; Vari, R; Veneziano, Stefano

    2003-01-01

    The ATLAS barrel level-1 muon trigger processes hit information from the resistive plate chamber detector, identifying candidate muon tracks and assigning them to a programmable p/sub T/ range and to a unique bunch crossing number. The trigger system uses up to seven detector layers and seeks hit patterns compatible with muon tracks in the bending and nonbending projection. The basic principle of the algorithm is to demand a coincidence of hits in the different chamber layers within a path. The width of the road is related to the p/sub T / threshold to be applied. The system is split into an on-detector and an off-detector part. The on-detector electronics reduces the information from about 350 k channels to about 400 32-bit data words sent via optical fiber to the so-called sector logic (SL). The off- detector SL electronics collects muon candidates and associates them to detector regions-of-interest of Delta eta * Delta Phi of 0.1*0.1. The core of the on-detector electronics is the coincidence matrix ASIC (...

  4. [The guiacum barrels between science and esoterism: Tommaso Campailla genius loci].

    Science.gov (United States)

    Buscemi, Maria

    2007-01-01

    Tommaso Campailla, as a typical man of his time, had a good humanistic and scientific education. He was born in Modica in 1668 [corrected] from an aristocratic family. When he was sixteen years old he moved to Catania to study law, but in a short time he came back to his native town where he preferred to study as an autodidact. He got married and had children and was elected senator seven times. In spite of his particular look, he was appreciated for his vast culture and his great sensibility. Giovanna Finocchiaro Chimirri noticed his very kind soul and called him: "the christian and Italian Lucretio". In addition, he was a friend of the Arcadian poet Girolama Lorefice Grimaldi. Campailla was a very good medical doctor, although he was an autodidact, and he was very able to inculcate love for medical studies in many students. He fought syphilis rheumatism in a "modern" way, using the "guaiacum barrels" or "vapour stovens" that he had invented. He died in 1740 in Modica. PMID:18450036

  5. Real-Time Million-Synapse Simulation of Rat Barrel Cortex

    Directory of Open Access Journals (Sweden)

    Thomas eSharp

    2014-05-01

    Full Text Available Simulations of neural circuits are bounded in scale and speed by available computing resources, and particularly by the differences in parallelism and communication patterns between the brain and high-performance computers. SpiNNaker is a computer architecture designed to address this problem by emulating the structure and function of neural tissue, using very many low-power processors and an interprocessor communication mechanism inspired by axonal arbors. Here we demonstrate that thousand-processor SpiNNaker prototypes can simulate models of the rodent barrel system comprising fifty thousand neurons and fifty million synapses. We use the PyNN library to specify models, and the intrinsic features of Python to control experimental procedures and analysis. The models reproduce known thalamocortical response transformations, exhibit known, balanced dynamics of excitation and inhibition, and show a spatiotemporal spread of activity though the superficial cortical layers. These demonstrations are a significant step towards tractable simulations of entire cortical areas on the million-processor SpiNNaker machines in development.

  6. The CERN Cryogenic Test Facility for the Atlas Barrel Toroid Magnets

    CERN Document Server

    Haug, F; Delruelle, N; Orlic, J P; Passardi, Giorgio; Tischhauser, Johann

    1999-01-01

    The superconducting magnet system of the ATLAS detector will consist of a central solenoid, two end-cap toroidal magnets (ECT) and the barrel toroid magnet (BT) made of eight coils symmetrically placed around the central axis of the detector. The magnets will be tested individually in a 5000 m2 experimental area prior to their final installation at an underground cavern of the LHC Collider. For the BT magnets, a dedicated cryogenic test facility has been designed which is currently under the construction and commissioning phase. A liquid nitrogen pre-cooling unit and a 1200 W@4.5K refrigerator will allow flexible operating conditions via a rather complex distribution and transfer line system. Flow of two-phase helium for cooling the coils is provided by centrifugal pumps immersed in a saturated liquid helium bath. The integration of the pumps in an existing cryostat required the adoption of novel mechanical solutions. Tests conducted permitted the validation of the technical design of the cryostat and its ins...

  7. The First ATLAS Barrel Toroid Coil Successfully Tested in Hall 180

    CERN Multimedia

    Rabbers, J J

    2004-01-01

    The first Barrel Toroid coil has been successfully tested with magnetic mirror at nominal current I=20.5 kA, up to a maximum current Imax=22 kA. After 14 days of cooling down, BT1 reached 4.5 Kelvin and the test program started on September 2nd. First the instrumentation and safety systems of the coil were tested at relatively low operating currents, up to 5 kA. Since all the systems and the coil were performing well, the current was increased by steps in several runs, while monitoring and evaluating the temperatures, voltages and mechanics. On early Wednesday morning September 8th the current was ramped up to 22 kA, shown by the red curve in the picture shown below: Thereafter the current was ramped down by a slow dump, where the stored energy of about 130 MJ is dissipated in a resistor/diode ramp down unit. This is the regular way of ramping down the current, which takes about one hour. Thereafter the current was ramped up to 22 kA for a second time, this time a so-called fast dump was initiated, ...

  8. RANCANGAN SISTEM INFORMASI PENGENDALIAN KUALITAS PRODUK BARREL PADA PT ONEJECT INDONESIA DENGAN METODE SIX SIGMA

    Directory of Open Access Journals (Sweden)

    J. Sudirwan

    2013-11-01

    Full Text Available PT OneJect Indonesia faces the high level of defect on its barrel products. To overcome this problem, this study proposes an application quality control based on information system. We implement requirement analysis based on the needs of quality control methods, while to lower the defect rate we utilize Six Sigma method with DMAIC (define, measure, analyze, improve, control phases. In define phase we determine the type of product to be investigated using Critical to Quality, as well as the problems and objectives. In measure phase we calculate DPMO value and sigma level; sigma value of 3.520 is obtained. Then we calculate P control chart to see the production process control. In analyze phase we create pareto diagram to see the types of dominant defects. Then we create cause-and-effect diagram to determine the cause of defects, and five whys diagram to determine the root causes of the defects. In improve phase, we do improvement analysis through FMEA table by calculating the RPN value to determine the failure modes to be controlled. In control phase, we implement the proposal and simulation of sigma value increase. The analysis and design uses object-oriented information system by Lars Mathiasen, and UML as the requirement modeling and the design system. The results obtained are the documents of top-level analysis and design of information system as a quality control material for the actual system development.

  9. Barrel time-of-flight detector for the PANDA experiment at FAIR

    CERN Document Server

    Gruber, L; Marton, J; Orth, H; Suzuki, K

    2015-01-01

    The barrel time-of-flight detector for the PANDA experiment at FAIR is foreseen as a Scintillator Tile (SciTil) Hodoscope based on several thousand small plastic scintillator tiles read-out with directly attached Silicon Photomultipliers (SiPMs). The main tasks of the system are an accurate determination of the time origin of particle tracks to avoid event mixing at high collission rates, relative time-of-flight measurements as well as particle identification in the low momentum regime. The main requirements are the use of a minimum material amount and a time resolution of $\\sigma < 100\\,\\mathrm{ps}$. We have performed extensive optimization studies and prototype tests to prove the feasibility of the SciTil design and finalize the R&D phase. In a 2.7 GeV/c proton beam at Forschungszentrum J\\"ulich a time resolution of about 80 ps has been achieved using SiPMs from KETEK and Hamamatsu with an active area of $3\\times3\\,\\mathrm{mm^2}$. Employing the Digital Photon Counter from Philips a time resolution of...

  10. Barrel time-of-flight detector for the PANDA experiment at FAIR

    Science.gov (United States)

    Gruber, L.; Brunner, S. E.; Marton, J.; Orth, H.; Suzuki, K.

    2016-07-01

    The barrel time-of-flight detector for the PANDA experiment at FAIR is foreseen as a Scintillator Tile (SciTil) Hodoscope based on several thousand small plastic scintillator tiles read-out with directly attached Silicon Photomultipliers (SiPMs). The main tasks of the system are an accurate determination of the time origin of particle tracks to avoid event mixing at high collision rates, relative time-of-flight measurements as well as particle identification in the low momentum regime. The main requirements are the use of a minimum material amount and a time resolution of σ < 100 ps. We have performed extensive optimization studies and prototype tests to prove the feasibility of the SciTil design and finalize the R&D phase. In a 2.7 GeV/c proton beam at Forschungszentrum Jülich a time resolution of about 80 ps has been achieved using SiPMs from KETEK and Hamamatsu with an active area of 3 × 3mm2. Employing the Digital Photon Counter from Philips a time resolution of about 30 ps has been reached.

  11. Predicted performance of systems for Bulk Soil Assay, Barrel Inspection, and Decommissioning

    International Nuclear Information System (INIS)

    In this project performances are predicted for new neutron interrogation systems designed to detect pollutant elements, uranium and transuranics (TRU), and gamma-ray emitters for Bulk Soil Assay, Barrel Inspection, and Decommissioning problems in the DOE Environment Restoration program. These new systems, which are based on the associated-particle time-of-flight (APTOF) technology are expected to save up to four times their $1.00 per hour operating costs relative to their alternatives for these problems. The key component required for practical use of the APTOF technology is a small sealed-tube neutron-generator (STNG) that incorporates a position sensitive alpha detector used to sense the alpha particle associated with emission of a 14-MeV neutron in the (D,T) reaction. The STNG makes possible a unique Inelastic-Gamma Imaging and Spectroscopy (IGRIS) system which provides a coarse three-dimensional image of the densities of elements in a target. Additional measurement capabilities as Capture-Gamma Ray Spectroscopy (CGRS) carried out simultaneously with IGRIS, Passive (STNG off) Gamma Ray Spectroscopy (PGRS), and Gamma-Ray Coincidence Spectroscopy (GRCS) carried out simultaneously with IGRIS, CGRS, and PGRS. These measurements are complementary and synergistic with each other. For example, the imaging capability of IGRIS can be used to estimate neutron and gamma-ray attenuations to correct any of these measurements. Predicted minimum detectable levels (MDLS) for several elements and radionuclides were measured and are presented

  12. Bad Apples, Bad Barrel: Exploring Institutional Responses to Child Sexual Abuse by Catholic Clergy in Australia

    Directory of Open Access Journals (Sweden)

    Jodi Death

    2015-07-01

    Full Text Available This paper considers constructions of institutional culture and power in the cover-up of child sexual abuse (CSA by clergy in the Roman Catholic Church of Australia. The issue of cover-up has previously been considered in international inquiries as an institutional failing that has caused significant harm to victims of CSA by Catholic Clergy. Evidence given by select representatives of the Catholic Church in two government inquiries into institutional abuse carried out in Australia is considered here. This evidence suggests that, where cover-up has occurred, it has been reliant on the abuse of institutional power and resulted in direct emotional, psychological and spiritual harm to victims of abuse. Despite international recognition of cover-up as institutional abuse, evidence presented by Roman Catholic Representatives to the Victorian Inquiry denied there was an institutionalised cover-up. Responding to this evidence, this paper queries whether the primary foundation of cover-up conforms to the ‘bad apple theory’ in that it relates only to a few individuals, or the ‘bad barrel theory’ of institutional structure and culture.

  13. The baffle-barrel-bolting analysis program: evolution and technical accomplishments

    Energy Technology Data Exchange (ETDEWEB)

    Schwirian, R.E.; Forsyth, D.R.; Snyder, M.D.; Bhandari, D.R.; Barsic, J.A.; Rabenstein, W.D. [Westinghouse Electric Company, Pittsburgh, Pennsylvania (United States)

    2001-07-01

    In Westinghouse pressurized water reactors (PWR) the reactor core is surrounded by baffle plates, which provide lateral restraint for the fuel assemblies at the core boundary. Baffle plates are attached to horizontal supports called former plates by baffle-former bolts. The formers are attached to the core barrel which also provides vertical support for the core. The B3 analysis program addresses the possibility of reduced baffle-former bolting in Westinghouse U.S. domestic plant designs with respect to the relevant design criteria. Since safety is the overriding motivation for the program, faulted events have received the most in-depth attention. This focus has been reinforced by the fact that the loads produced by the loss-of-coolant-accident (LOCA) have usually been the most limiting of all those considered. Consequently, much of the presentation below deals with the development of analysis techniques and acceptance criteria to demonstrate that LOCA-induced loads on the bolts and the fuel assemblies will be acceptable with significantly reduced baffle-former bolting. A discussion of the other faulted, normal, and upset analyses performed as part of the program will also be presented. (author)

  14. A dynamic model for generating actuator specifications for small arms barrel active stabilization

    Science.gov (United States)

    Pathak, Anupam; Brei, Diann; Luntz, Jonathan; Lavigna, Chris

    2006-03-01

    Due to stresses encountered in combat, it is known that soldier marksmanship noticeably decreases regardless of prior training. Active stabilization systems in small arms have potential to address this problem to increase soldier survivability and mission effectiveness. The key to success is proper actuator design, but this is highly dependent on proper specification which is challenging due to the human/weapon interaction. This paper presents a generic analytical dynamic model which is capable of defining the necessary actuation specifications for a wide range of small arms platforms. The model is unique because it captures the human interface--shoulder and arm--that introduces the jitter disturbance in addition to the geometry, inertial properties and active stabilization stiffness of the small arms platform. Because no data to date is available for actual shooter-induced disturbance in field conditions, a method is given using the model to back-solve from measured shooting range variability data the disturbance amplitude information relative to the input source (arm or shoulder). As examples of the applicability of the model to various small arms systems, two different weapon systems were investigated: the M24 sniper weapon and the M16 assault rifle. In both cases, model based simulations provided valuable insight into impact on the actuation specifications (force, displacement, phase, frequency) due to the interplay of the human-weapon-active stabilization interface including the effect of shooter-disturbance frequency, disturbance location (shoulder vs. arm), and system parameters (stiffness, barrel rotation).

  15. Crystal Structure of Barrel-Shaped Chiral Au130(p-MBT)50 Nanocluster.

    Science.gov (United States)

    Chen, Yuxiang; Zeng, Chenjie; Liu, Chong; Kirschbaum, Kristin; Gayathri, Chakicherla; Gil, Roberto R; Rosi, Nathaniel L; Jin, Rongchao

    2015-08-19

    We report the structure determination of a large gold nanocluster formulated as Au130(p-MBT)50, where p-MBT is 4-methylbenzenethiolate. The nanocluster is constructed in a four-shell manner, with 55 gold atoms assembled into a two-shell Ino decahedron. The surface is protected exclusively by -S-Au-S- staple motifs, which self-organize into five ripple-like stripes on the surface of the barrel-shaped Au105 kernel. The Au130(p-MBT)50 can be viewed as an elongated version of the Au102(SR)44. Comparison of the Au130(p-MBT)50 structure with the recently discovered icosahedral Au133(p-TBBT)52 nanocluster (where p-TBBT = 4-tert-butylbenzenethiolate) reveals an interesting phenomenon that a subtle ligand effect in the para-position of benzenethiolate can significantly affect the gold atom packing structure, i.e. from the 5-fold twinned Au55 decahedron to 20-fold twinned Au55 icosahedron. PMID:26244606

  16. Superconducting Magnet with the Reduced Barrel Yoke for the Hadron Future Circular Collider

    CERN Document Server

    Klyukhin, V I; Berriaud, C; Curé, B; Dudarev, A; Gaddi, A; Gerwig, H; Hervé, A; Mentink, M; Rolando, G; Da Silva, H F Pais; Wagner, U; Kate, H H J ten

    2015-01-01

    The conceptual design study of a hadron Future Circular Collider (FCC-hh) with a center-of-mass energy of the order of 100 TeV in a new tunnel of 80-100 km circumference assumes the determination of the basic requirements for its detectors. A superconducting solenoid magnet of 12 m diameter inner bore with the central magnetic flux density of 6 T is proposed for a FCC-hh experimental setup. The coil of 24.518 m long has seven 3.5 m long modules included into one cryostat. The steel yoke with a mass of 21 kt consists of two barrel layers of 0.5 m radial thickness, and 0.7 m thick nose disk, four 0.6 m thick end-cap disks, and three 0.8 m thick muon toroid disks each side. The outer diameter of the yoke is 17.7 m; the length without the forward muon toroids is 33 m. The air gaps between the end-cap disks provide the installation of the muon chambers up to the pseudorapidity of \\pm 3.5. The conventional forward muon spectrometer provides the measuring of the muon momenta in the pseudorapidity region from \\pm 2.7...

  17. Upregulation of barrel GABAergic neurons is associated with cross-modal plasticity in olfactory deficit.

    Directory of Open Access Journals (Sweden)

    Hong Ni

    Full Text Available BACKGROUND: Loss of a sensory function is often followed by the hypersensitivity of other modalities in mammals, which secures them well-awareness to environmental changes. Cellular and molecular mechanisms underlying cross-modal sensory plasticity remain to be documented. METHODOLOGY/PRINCIPAL FINDINGS: Multidisciplinary approaches, such as electrophysiology, behavioral task and immunohistochemistry, were used to examine the involvement of specific types of neurons in cross-modal plasticity. We have established a mouse model that olfactory deficit leads to a whisking upregulation, and studied how GABAergic neurons are involved in this cross-modal plasticity. In the meantime of inducing whisker tactile hypersensitivity, the olfactory injury recruits more GABAergic neurons and their fine processes in the barrel cortex, as well as upregulates their capacity of encoding action potentials. The hyperpolarization driven by inhibitory inputs strengthens the encoding ability of their target cells. CONCLUSION/SIGNIFICANCE: The upregulation of GABAergic neurons and the functional enhancement of neuronal networks may play an important role in cross-modal sensory plasticity. This finding provides the clues for developing therapeutic approaches to help sensory recovery and substitution.

  18. Formation of dot arrays with a pitch of 20 nm x 20 nm for patterned media using 30 keV EB drawing on thin calixarene resist

    Energy Technology Data Exchange (ETDEWEB)

    Mohamad, Zulfakri bin [Department of Nano-Material System, Graduate School of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515 (Japan); Shirai, Masumi [Department of Nano-Material System, Graduate School of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515 (Japan); Sone, Hayato [Department of Production Science and Technology, Graduate School of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515 (Japan); Hosaka, Sumio [Department of Production Science and Technology, Graduate School of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515 (Japan); Kodera, Masatoshi [Department of Electronics, Information and Communication Engineering, Osaka Institute of Technology, 5-16-1 Omiya, Asahi-ku, Osaka 535-8585 (Japan)

    2008-01-16

    We studied the possibility of achieving very fine-pitch dot arrays with a pitch of 20 nm x 20 nm using 30 keV electron beam (EB) drawing on negative calixarene resist. In order to form such patterns, we studied the dependence on resist thickness of the dot size and the packing. We propose EB drawing on an extremely thin film for very highly packed dot-array formation. Our experimental results demonstrate the possibility of forming highly packed dot-array patterns with a pitch of 20 nm x 20 nm and a resist thickness of about 13 nm, which corresponds to about 1.6 Tbits in{sup -2}.

  19. 1,6-Bis(4-vinylphenyl)hexane as a crosslinking agent for the preparation of crosslinked sulfonated poly(ether ether ketone) membranes by EB irradiation

    International Nuclear Information System (INIS)

    In order to mitigate problems associated with highly sulfonated aromatic hydrocarbon membranes, such as dimensional stability, mechanical strength, and methanol crossover, sulfonated poly(ether ether ketone) (SPEEK) membranes containing 1,6-bis(4-vinylphenyl)hexane (BVPH) were crosslinked by EB irradiation. Compared to the pristine SPEEK membrane, the crosslinked membranes exhibited significantly improved dimensional stability, chemical stability, and mechanical strength. The crosslinking procedure slightly reduced the proton conductivity of the membranes. The crosslinking of SPEEK with BVPH was also found to slightly reduce the proton conductivity of the membranes, but significantly reduced the methanol permeability. - Highlights: • 1,6-Bis(4-vinylphenyl)hexane (BVPH) was prepared as a crosslinking agent. • Sulfonated poly(ether ether ketone) was crosslinked using BVPH via EB irradiation. • The crosslinked membranes showed greatly improved dimensional and chemical stability. • The crosslinking process only slightly decreased the proton conductivity. • The crosslinked membranes exhibited substantially reduced methanol permeability

  20. Results of immediate loading for implant restoration in partially edentulous patients: a 6-month preliminary prospective study using SinusQuick™ EB implant system

    OpenAIRE

    Kim, Jong-Hwa; Kim, Young-Kyun; Yi, Yang-Jin; Yun, Pil-Young; Lee, Hyo-Jung; Kim, Myung-Jin; Yeo, In-Sung

    2009-01-01

    STATEMENT OF PROBLEM Many dental clinicians are concerned about immediate loading of inserted implants. However, there have been few clinical studies surveying the success rates of immediate loading, based on Korean implant systems. PURPOSE The aim of this study was to evaluate the outcome of immediate functional loading of the implant (SinusQuick™ EB, Neobiotech Co., Seoul, Korea) in partially edentulous maxilla or mandible. MATERIAL AND METHODS Total 15 implants were placed. Within 2 weeks ...

  1. EB-PVD热障涂层热循环性能评价方法研究%Evaluation Method of Thermal Cycling Property of EB-PVD Thermal Barrier Coatings

    Institute of Scientific and Technical Information of China (English)

    陈立强; 宫声凯; 徐惠彬

    2013-01-01

    制备8批次EB-PVD双层结构热障涂层试样,采用循环加热快速冷却实验装置模拟热障涂层服役环境,开展了热障涂层试样在不同热循环保温时间条件下的热循环性能评价实验,采用指数下降的数学模型对热循环实验数据进行拟合分析,获得了表征热障涂层试样静态氧化性能和热疲劳性能的物理量.结果表明,在本实验工艺条件下制备的不同批次热障涂层试样的静态氧化性能和热疲劳性能具有不同的匹配关系,热障涂层试样静态氧化性能总体估计值为(677±194)h,热疲劳性能总体估计值为(6789±1818)次.%Thermal cycling testing to the 8 batches of thermal barrier coating samples for different holding time was carried out by means of cycling heating and cooling apparatus to simulate TBCs service environment. Using a mathematical model of exponential decline to fit thermal cycle experimental data, characterization parameters of static oxidation performance and thermal fatigue performance of thermal barrier coated samples were obtained. The result indicates that static state oxidation performance and thermal fatigue performance of TBCs samples prepared under present experimental technology conditions have different match relation. The estimated value for static state oxidation performance is 677±194 h, and the estimated value for thermal fatigue performance is 6789±1818 times.

  2. Investigation of EMIC Wave Scattering as the Cause for the BARREL January 17, 2013 Relativistic Electron Precipitation Event

    Science.gov (United States)

    Li, Z.; Millan, R. M.; Hudson, M. K.; Woodger, L. A.; Fennell, J. F.; Engebretson, M. J.; MacDonald, E.

    2013-12-01

    Scattering by electromagnetic ion cyclotron (EMIC) waves has been suggested to be a major cause of relativistic electron precipitation (REP). This mechanism has also been proposed as the cause for REP observed by balloon-borne detectors predominantly in the dusk sector. Observations from the recent BARREL balloon campaign, along with simultaneous detailed spacecraft measurements of waves and plasma conditions, give us an unprecedented opportunity to investigate this mechanism. We simulate relativistic electron pitch-angle diffusion by EMIC waves using wave and particle data measured by GOES and the Van Allen Probes, and compare the energy distribution of the resulting precipitation with BARREL observations of precipitation made on January 17, 2013. This comparison sheds light on the role of EMIC waves in causing REP as well as the effectiveness of the quasi-linear model.

  3. Construction and first characterisation of a prototype for the PANDA barrel EMC in a close to final design

    Energy Technology Data Exchange (ETDEWEB)

    Rosenbaum, Christoph; Bremer, Daniel; Diehl, Stefan; Drexler, Peter; Dormenev, Valery; Eissner, Tobias; Kuske, Till; Novotny, Rainer W.; Zaunick, Hans-Georg [2. Physics Institute, University Giessen (Germany); Le Galliard, Christine; Imre, Miktat; Marchand, Dominique; Rosier, Phillippe [IPN Orsay (France); Kavatsyuk, Myroslav [KVI Groningen (Netherlands); Ryantzev, Andrej [IHEP Protvino (Russian Federation); Wieczorek, Peter; Wilms, Andrea [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Collaboration: PANDA-Collaboration

    2014-07-01

    The EMC of the PANDA target spectrometer is one of the central detector components to achieve the physical goals. The barrel part will consist of lead tungstate (PWO) crystals operated at -25 C to achieve the required performance over a wide energy range. To achieve a good energy, position and time resolution, it is necessary to perform detailed tests of prototypes. The most recent one, PROTO120, represents a subsection of the barrel EMC. The design is close to the final concept of the EMC with respect to the detector assembly, cooling circuit and front-end electronics. The conversion of the scintillation light will be performed with two rectangular LAAPD, which are read-out separately via the APFEL-ASIC providing a large dynamic range, low power consumption and the optimized shaping. The talk describes the details of the construction and a first test on the performance based on cosmic muons.

  4. Comparison between Duncan and Chang’s EB Model and the Generalized Plasticity Model in the Analysis of a High Earth-Rockfill Dam

    Directory of Open Access Journals (Sweden)

    Weixin Dong

    2013-01-01

    Full Text Available Nonlinear elastic model and elastoplastic model are two main kinds of constitutive models of soil, which are widely used in the numerical analyses of soil structure. In this study, Duncan and Chang's EB model and the generalized plasticity model proposed by Pastor, Zienkiewicz, and Chan was discussed and applied to describe the stress-strain relationship of rockfill materials. The two models were validated using the results of triaxial shear tests under different confining pressures. The comparisons between the fittings of models and test data showed that the modified generalized plasticity model is capable of simulating the mechanical behaviours of rockfill materials. The modified generalized plasticity model was implemented into a finite element code to carry out static analyses of a high earth-rockfill dam in China. Nonlinear elastic analyses were also performed with Duncan and Chang's EB model in the same program framework. The comparisons of FEM results and in situ monitoring data showed that the modified PZ-III model can give a better description of deformation of the earth-rockfill dam than Duncan and Chang’s EB model.

  5. Characterization of Type I and Type II nNOS-Expressing Interneurons in the Barrel Cortex of Mouse

    OpenAIRE

    Quentin ePerrenoud; Hélène eGeoffroy; Benjamin eGautier; Armelle eRancillac; Fabienne eAlfonsi; Nicoletta eKessaris; Jean eRossier; Tania eVitalis; Thierry eGallopin

    2012-01-01

    In the neocortex, neuronal nitric oxide (NO) synthase (nNOS) is essentially expressed in two classes of GABAergic neurons: type I neurons displaying high levels of expression and type II neurons displaying weaker expression. Using immunocytochemistry in mice expressing GFP under the control of the glutamic acid decarboxylase 67k (GAD67) promoter, we studied the distribution of type I and type II neurons in the barrel cortex and their expression of parvalbumin (PV), somatostatin (SOM), and vas...

  6. Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs

    OpenAIRE

    Zhang Guanjun; Gao Zilong; Guan Sudong; Zhu Yan; Wang Jin-Hui

    2013-01-01

    Abstract Loss of a sensory input causes the hypersensitivity in other modalities. In addition to cross-modal plasticity, the sensory cortices without receiving inputs undergo the plastic changes. It is not clear how the different types of neurons and synapses in the sensory cortex coordinately change after input deficits in order to prevent loss of their functions and to be used for other modalities. We studied this subject in the barrel cortices from whiskers-trimmed mice vs. controls. After...

  7. A new intraretinal recording system with multiple-barreled electrodes for pharmacological studies on cat retinal ganglion cells.

    Science.gov (United States)

    Takao, M; Wang1, Y; Miyoshi, T; Fujita, I; Fukuda, Y

    2000-04-01

    To overcome technical difficulties associated with in vivo intraretinal recordings of cat retinal ganglion cells (RGCs) with multiple-barreled electrodes, we developed a new guide-trocar system that consisted of a small-diameter and large-diameter pipes. We also improved the method to construct tungsten-in-glass multiple-barreled electrodes suitable for intraretinal recording from RGCs. Only the small-diameter pipe was inserted into the eye ball through the sclera, through which only the taper part of a multiple-barreled electrode pass. The large-diameter pipe stably held the electrode at its trunk and remained outside the eye ball. Insertion of only the small-diameter pipe minimized damages in the eye ball and prevented the eye ball movements while positioning the electrode. The system allowed us to keep the recordings stable for more than 1 h. Iontophoretically applied L-glutamate successfully activated RGCs of both X and Y types in the cat retina. PMID:10771079

  8. Increases in the numerical density of GAT-1 positive puncta in the barrel cortex of adult mice after fear conditioning.

    Directory of Open Access Journals (Sweden)

    Ewa Siucinska

    Full Text Available Three days of fear conditioning that combines tactile stimulation of a row of facial vibrissae (conditioned stimulus, CS with a tail shock (unconditioned stimulus, UCS expands the representation of "trained" vibrissae, which can be demonstrated by labeling with 2-deoxyglucose in layer IV of the barrel cortex. We have also shown that functional reorganization of the primary somatosensory cortex (S1 increases GABAergic markers in the hollows of "trained" barrels of the adult mouse. This study investigated how whisker-shock conditioning (CS+UCS affected the expression of puncta of a high-affinity GABA plasma membrane transporter GAT-1 in the barrel cortex of mice 24 h after associative learning paradigm. We found that whisker-shock conditioning (CS+UCS led to increase expression of neuronal and astroglial GAT-1 puncta in the "trained" row compared to controls: Pseudoconditioned, CS-only, UCS-only and Naïve animals. These findings suggest that fear conditioning specifically induces activation of systems regulating cellular levels of the inhibitory neurotransmitter GABA.

  9. A practical fan-beam design and reconstruction algorithm for Active and Passive Computed Tomography of radioactive waste barrels

    Energy Technology Data Exchange (ETDEWEB)

    Roy, Tushar, E-mail: tushar@barc.gov.in; More, M.R.; Ratheesh, Jilju; Sinha, Amar

    2015-09-11

    Active and Passive CT (A&PCT) of waste barrels is mostly carried out in parallel beam configuration due to its relative ease of implementation. This necessitates either using a single detector–source pair and translating the barrel or using multiple detector–source pairs for increasing the scanning speed. Additionally, because the use of bulky HPGe detectors may limit the number of detectors used in both active and passive modes, we propose to use 1″×1″ LaBr{sub 3}(Ce) scintillators. This paper describes a practical fan-beam reconstruction for A&PCT imaging of waste barrels. A fan beam system model has been computed analytically and reconstruction done using MLEM algorithm. The results are compared with analytical reconstruction. - Highlights: • Fan beam geometry with equally spaced detectors implemented for A&PCT. • Analytical computation of system matrix for fan beam geometry. • Implementation of fan beam with single active source in A&PCT.

  10. Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex.

    Directory of Open Access Journals (Sweden)

    Malgorzata Jasinska

    Full Text Available Associative fear learning, resulting from whisker stimulation paired with application of a mild electric shock to the tail in a classical conditioning paradigm, changes the motor behavior of mice and modifies the cortical functional representation of sensory receptors involved in the conditioning. It also induces the formation of new inhibitory synapses on double-synapse spines of the cognate barrel hollows. We studied density and distribution of polyribosomes, the putative structural markers of enhanced synaptic activation, following conditioning. By analyzing serial sections of the barrel cortex by electron microscopy and stereology, we found that the density of polyribosomes was significantly increased in dendrites of the barrel activated during conditioning. The results revealed fear learning-induced increase in the density of polyribosomes associated with both excitatory and inhibitory synapses located on dendritic spines (in both single- and double-synapse spines and only with the inhibitory synapses located on dendritic shafts. This effect was accompanied by a significant increase in the postsynaptic density area of the excitatory synapses on single-synapse spines and of the inhibitory synapses on double-synapse spines containing polyribosomes. The present results show that associative fear learning not only induces inhibitory synaptogenesis, as demonstrated in the previous studies, but also stimulates local protein synthesis and produces modifications of the synapses that indicate their potentiation.

  11. Comments on: Further studies of Bolivian crocidolite-Part IV: Fibre width, fibre drift and their relation to mesothelioma induction: Preliminary findings, by Ilgren EB, van Orden DR, Lee RJ, Kamiya YM, Hoskins JA.

    Directory of Open Access Journals (Sweden)

    Corrado Magnani

    2016-03-01

    Full Text Available Comments on: Further studies of Bolivian crocidolite-Part IV: Fibre width, fibre drift and their relation to mesothelioma induction: Preliminary findings, by Ilgren EB, van Orden DR, Lee RJ, Kamiya YM, Hoskins JA.

  12. Transcriptional activity of the giant barrel sponge, Xestospongia muta Holobiont: Molecular Evidence for Metabolic Interchange

    Directory of Open Access Journals (Sweden)

    Cara L Fiore

    2015-04-01

    Full Text Available Compared to our understanding of the taxonomic composition of the symbiotic microbes in marine sponges, the functional diversity of these symbionts is largely unknown. Furthermore, the application of genomic, transcriptomic, and proteomic techniques to functional questions on sponge host-symbiont interactions is in its infancy. In this study, we generated a transcriptome for the host and a metatranscriptome of its microbial symbionts for the giant barrel sponge, Xestospongia muta, from the Caribbean. In combination with a gene-specific approach, our goals were to 1 characterize genetic evidence for nitrogen cycling in X. muta, an important limiting nutrient on coral reefs 2 identify which prokaryotic symbiont lineages are metabolically active and, 3 characterize the metabolic potential of the prokaryotic community. Xestospongia muta expresses genes from multiple nitrogen transformation pathways that when combined with the abundance of this sponge, and previous data on dissolved inorganic nitrogen fluxes, shows that this sponge is an important contributor to nitrogen cycling on coral reefs. Additionally, we observed significant differences in gene expression of the archaeal amoA gene, which is involved in ammonia oxidation, between coral reef locations consistent with differences in the fluxes of dissolved inorganic nitrogen previously reported. In regards to symbiont metabolic potential, the genes in the biosynthetic pathways of several amino acids were present in the prokaryotic metatranscriptome dataset but in the host-derived transcripts only the catabolic reactions for these amino acids were present. A similar pattern was observed for the B vitamins (riboflavin, biotin, thiamin, cobalamin. These results expand our understanding of biogeochemical cycling in sponges, and the metabolic interchange highlighted here advances the field of symbiont physiology by elucidating specific metabolic pathways where there is high potential for host

  13. Optimizing nanodiscs and bicelles for solution NMR studies of two β-barrel membrane proteins

    International Nuclear Information System (INIS)

    Solution NMR spectroscopy has become a robust method to determine structures and explore the dynamics of integral membrane proteins. The vast majority of previous studies on membrane proteins by solution NMR have been conducted in lipid micelles. Contrary to the lipids that form a lipid bilayer in biological membranes, micellar lipids typically contain only a single hydrocarbon chain or two chains that are too short to form a bilayer. Therefore, there is a need to explore alternative more bilayer-like media to mimic the natural environment of membrane proteins. Lipid bicelles and lipid nanodiscs have emerged as two alternative membrane mimetics that are compatible with solution NMR spectroscopy. Here, we have conducted a comprehensive comparison of the physical and spectroscopic behavior of two outer membrane proteins from Pseudomonas aeruginosa, OprG and OprH, in lipid micelles, bicelles, and nanodiscs of five different sizes. Bicelles stabilized with a fraction of negatively charged lipids yielded spectra of almost comparable quality as in the best micellar solutions and the secondary structures were found to be almost indistinguishable in the two environments. Of the five nanodiscs tested, nanodiscs assembled from MSP1D1ΔH5 performed the best with both proteins in terms of sample stability and spectral resolution. Even in these optimal nanodiscs some broad signals from the membrane embedded barrel were severely overlapped with sharp signals from the flexible loops making their assignments difficult. A mutant OprH that had two of the flexible loops truncated yielded very promising spectra for further structural and dynamical analysis in MSP1D1ΔH5 nanodiscs

  14. Optimizing nanodiscs and bicelles for solution NMR studies of two β-barrel membrane proteins

    Energy Technology Data Exchange (ETDEWEB)

    Kucharska, Iga [University of Virginia, Center for Membrane Biology and Department of Molecular Physiology and Biological Physics (United States); Edrington, Thomas C. [Monsanto Company (United States); Liang, Binyong; Tamm, Lukas K., E-mail: Lkt2e@virginia.edu [University of Virginia, Center for Membrane Biology and Department of Molecular Physiology and Biological Physics (United States)

    2015-04-15

    Solution NMR spectroscopy has become a robust method to determine structures and explore the dynamics of integral membrane proteins. The vast majority of previous studies on membrane proteins by solution NMR have been conducted in lipid micelles. Contrary to the lipids that form a lipid bilayer in biological membranes, micellar lipids typically contain only a single hydrocarbon chain or two chains that are too short to form a bilayer. Therefore, there is a need to explore alternative more bilayer-like media to mimic the natural environment of membrane proteins. Lipid bicelles and lipid nanodiscs have emerged as two alternative membrane mimetics that are compatible with solution NMR spectroscopy. Here, we have conducted a comprehensive comparison of the physical and spectroscopic behavior of two outer membrane proteins from Pseudomonas aeruginosa, OprG and OprH, in lipid micelles, bicelles, and nanodiscs of five different sizes. Bicelles stabilized with a fraction of negatively charged lipids yielded spectra of almost comparable quality as in the best micellar solutions and the secondary structures were found to be almost indistinguishable in the two environments. Of the five nanodiscs tested, nanodiscs assembled from MSP1D1ΔH5 performed the best with both proteins in terms of sample stability and spectral resolution. Even in these optimal nanodiscs some broad signals from the membrane embedded barrel were severely overlapped with sharp signals from the flexible loops making their assignments difficult. A mutant OprH that had two of the flexible loops truncated yielded very promising spectra for further structural and dynamical analysis in MSP1D1ΔH5 nanodiscs.

  15. Ectopic Expression of a Phytase Gene from Medicago truncatula Barrel Medic Enhances Phosphorus Absorption in Plants

    Institute of Scientific and Technical Information of China (English)

    Kai Xiao; Jian-Heng Zhang; Maria Harrison; Zeng-Yu Wang

    2006-01-01

    In the present study, the phosphorus-absorption capacity of transgenic Arabidopsis plants ectopically expressing a novel phytase gene from Medicago truncatula Barrel Medic was evaluated. A full-length cDNA encoding an extracellular form of phytase was isolated from the model legume M. truncatula. The phytase gene (MtPHY1) has an open reading frame of 1 632 bp predicted to encode 543 amino acids, including an Nterminal signal peptide of 27 amino acids. The genomic sequence of the MtPHY1 gene is 5 151 bp, containing seven exons interrupted by six introns. Under high-Pi (2 mmol/L) growth conditions, higher levels of MtPHY1transcripts accumulated in the leaf and stem than in the root. The transcript level was reduced in the stem and increased in the root, with no obvious changes in the hybridization signal detected in the leaf under lowPi (10 μmol/L) conditions. Chimeric transgenes were constructed by placing MtPHY1 under the control of the constitutive CaMV35S promoter and the root-specific MtPT1 promoter. Phytase activities in root apoplast of transgenic Arabidopsis were 12.3- to 16.2-fold of that in control plants. The phytase expressed was secreted into the rhizosphere, as demonstrated by HPLC analysis of phytate degradation by root exudates. Ectopic expression of MtPHY1 in Arabidopsis, leading to significant improvement in organic phosphorus absorption and plant growth, indicated that MtPHY1 has great potential for improving plant phosphorus absorption and phytoremediation.

  16. Ellagitannin content, volatile composition and sensory profile of wines from different countries matured in oak barrels subjected to different toasting methods.

    Science.gov (United States)

    González-Centeno, M R; Chira, K; Teissedre, P-L

    2016-11-01

    Ellagitannins and aromatic compounds evolution in Cabernet Sauvignon wines macerated in oak barrels for a year was studied. Identical barrels with different toastings (medium toasting, medium toasting with watering, Noisette) were used in French, Italian and USA cellars. Ellagitannins increased by 84-96% with aging time, as did woody volatiles, by 86-91% in French wines and 23-35% in Italian wines, while fruity aroma compounds declined by 50-57% in the French and Italian wines over a 12-months period. Nevertheless, other behaviors and different kinetics rates for these compounds were observed depending on barrel toasting, wine matrix and their interactions. Perceived overall woody intensity was closely related to trans-whiskey lactone, guaiacol and vanillin, whereas astringency and bitterness were significantly linked to ellagitannins (p<0.05). This is the first study that evaluates the toasting effect on wines from different countries matured in the same oak barrels. PMID:27211676

  17. Variations in oxygen and ellagitannins, and organoleptic properties of red wine aged in French oak barrels classified by a near infrared system.

    Science.gov (United States)

    Michel, Julien; Albertin, Warren; Jourdes, Michael; Le Floch, Alexandra; Giordanengo, Thomas; Mourey, Nicolas; Teissedre, Pierre-Louis

    2016-08-01

    During wine aging in barrels, antioxidant molecules from wood, such as ellagitannins, are solubilized and react with wine molecules and oxygen. However, their concentrations are highly variable. Oxygen is an important factor, as it plays a role in wine parameters and organoleptic perceptions. Five barrel modalities were used; three polyphenol indices (IP), classified using the NIRS procedure, and three grain qualities. Barrels were equipped with windows to measure the oxygen using luminescence technology. The ellagitannin concentrations in the wine and its organoleptic properties were monitored. Oxygen concentrations decreased quickly during the first 8days of aging and this phenomenon was significantly more marked in barrels with a higher IP and medium grain. The ellagitannin concentrations were believed to be correlated with wood classification and oxygen consumption. Furthermore, the organoleptic properties were significantly impacted, as the wine with the lowest ellagitannin level was described as less astringent, bitter, woody, and smoky/toasty. PMID:26988516

  18. Interneto turinio reguliavimas EB

    OpenAIRE

    Norkevičiūtė, Dovilė

    2010-01-01

    XX a. pabaigoje tapęs pasauliniu tinklu, sparčiai besiplečiantis ir šiuo metu turintis daugiau nei milijardą vartotojų, internetas tapo svarbiu veiksniu ekonominiame, socialiniame, kultūriniame ir švietimo gyvenime. Internetas savo vartotojams suteikia prieigą prie visų laikų didžiausių informacijos klodų ir yra svarbus saviraiškos laisvės bei teisės skleisti ir gauti informaciją instrumentas. Tačiau šis potencialas ne visada panaudojamas teisėtiems tikslams, internete aptinkama ir problemini...

  19. Dam-induced and natural channel changes in the Saskatchewan River below the E.B. Campbell Dam, Canada

    Science.gov (United States)

    Smith, Norman D.; Morozova, Galina S.; Pérez-Arlucea, Marta; Gibling, Martin R.

    2016-09-01

    The E.B. Campbell Dam on the Saskatchewan River, east-central Saskatchewan, was constructed in 1962, forming Tobin Lake (2.2 billion m3 capacity), which today impounds most fluvial sediment and disrupts normal outflow patterns. Thirty-five kilometers below the dam, the river diverts into a 500 km2 belt of alluvial sediment initiated by an avulsion ~ 140 years ago, rejoining the parent channel 108 km from the dam. Effects of the dam on channel geomorphology, including the historical channel (reach I) and the more recent avulsion-affected channels, were investigated by pre- and post-dam cross section surveys combined with grain-size and bedload measurements. Twenty-three sites were surveyed at least twice, and 14 were resurveyed annually in 2003-2014 (except 2007) during which significant floods occurred in 2005, 2011, and 2013. All channel cross sections up to 81 km below the dam have coarsened and enlarged since closure, resulting in excavation of 35.4 × 106 m3 of channel-perimeter sediment since 1962. The most proximal segment is armored and has changed little in recent years. Since 2003, channel enlargement has been greatest in the 35-81 km segment between the avulsion site and the Forks (reaches II, III), manifested as widening and deepening. Enlargement rates were greatest during the three floods, and the paucity of bedload has prevented degraded portions of the channel bed from replenishment following flooding. Budget calculations based on bedload measurements and channel cross-section areas suggest that > 30 years would be required to replace the sediment removed between 2003 and 2014, assuming all available bedload remains in the affected reach. Dam effects appear to be absent or uncertain beyond 81 km, a multichanneled region of varied stages of activity (reach IV), recombining and eventually rejoining the parent Saskatchewan River channel at km 108 (reach V). Sediment evacuated from reaches I-III is sufficient to sustain modest aggradation in some distal

  20. Barrel organ of plate tectonics - a new tool for outreach and education

    Science.gov (United States)

    Broz, Petr; Machek, Matěj; Šorm, Zdar

    2016-04-01

    Plate tectonics is the major geological concept to explain dynamics and structure of Earth's outer shell, the lithosphere. In the plate tectonic theory processes in the Earth lithosphere and its dynamics is driven by the relative motion and interaction of lithospheric plates. Geologically most active regions on Earth often correlate with the lithospheric plate boundaries. Thus for explaining the earth surface evolution, mountain building, volcanism and earthquake origin it is important to understand processes at the plate boundaries. However these processes associated with plate tectonics usually require significant period of time to take effects, therefore, their entire cycles cannot be directly observed in the nature by humans. This makes a challenge for scientists studying these processes, but also for teachers and popularizers trying to explain them to students and to the general public. Therefore, to overcome this problem, we developed a mechanical model of plate tectonics enabling demonstration of most important processes associated with plate tectonics in real time. The mechanical model is a wooden box, more specifically a special type of barrel organ, with hand painted backdrops in the front side. These backdrops are divided into several components representing geodynamic processes associated with plate tectonics, specifically convective currents occurring in the mantle, sea-floor spreading, a subduction of the oceanic crust under the continental crust, partial melting and volcanism associated with subduction, a formation of magmatic stripes, an ascent of mantle plume throughout the mantle, a volcanic activity associated with hot spots, and a formation and degradation of volcanic islands on moving lithospheric plate. All components are set in motion by a handle controlled by a human operator, and the scene is illuminated with colored lights controlled automatically by an electric device embedded in the box. Operation of the model may be seen on www

  1. Comparison of orthogonal kilovolt X-ray images and cone-beam CT matching results in setup error assessment and correction for EB-PBI during free breathing

    International Nuclear Information System (INIS)

    Objective: To compare the differences in setup error (SE) assessment and correction between the orthogonal kilovolt X-ray images and CBCT in EB-PBI patients during free breathing. Methods: Nineteen patients after breast conserving surgery EB-PBI were recruited. Interfraction SE was acquired using orthogonal kilovolt X-ray setup images and CBCT, after on-line setup correction,calculate the residual error and compare the SE, residual error and setup margin (SM) quantified for orthogonal kilovolt X-ray images and CBCT. Wilcoxon sign-rank test was used to evaluate the differences. Results: The CBCT based SE (systematic error, ∑) was smaller than the orthogonal kilovolt X-ray images based ∑ in AP direction (-1.2 mm vs 2.00 mm; P=0.005), and there was no statistically significant differences for three dimensional directions in random error (σ) (P=0.948, 0.376, 0.314). After on-line setup correction,CBCT decreases setup residual error than the orthogonal kilovolt X-ray images in AP direction (Σ: -0.20 mm vs 0.50 mm, P=0.008; σ: 0.45 mm vs 1.34 mm, P=0.002). And also the CBCT based SM was smaller than orthogonal kilovolt X-ray images based SM in AP direction (Σ: -1.39 mm vs 5.57 mm, P=0.003; σ: 0.00 mm vs 3.2 mm, P=0.003). Conclusions: Compared with kilovolt X-ray images, CBCT underestimate the setup error in the AP direction, but decreases setup residual error significantly.An image-guided radiotherapy and setup error assessment using kilovolt X-ray images for EB-PBI plans was feasible. (authors)

  2. Hodnocení potenciálu rozvoje cestovního ruchu v okrese Třebíč

    OpenAIRE

    Nykrmajerová, Zuzana

    2014-01-01

    The aim of the bachelor thesis is to evaluate the tourism development potential in the district of Třebíč, but also to describe and analyze the district. A part of this thesis is a general characteristic of tourism, its forms and types and also the definition of the tourism development potential. A part of it is devoted to tourism organizations that help with the development of the district. The thesis is mainly based on a questionnaire survey of the general public. There was made a SWOT anal...

  3. Use of biogas biscuit meal EKPO-EB for agricultural biogas plant for substitution of energy crops utilization with organic waste

    OpenAIRE

    Chamrádová Kateřina; Rusín Jiří

    2015-01-01

    A laboratory experiment of two-stage mesophilic, low-dry mass, anaerobic digestion was carried out, focused on verifying the benefi t of processing the biscuit meal EKPO-EB instead of triticale silage Agostino (GPS) and corn silage LG3266 in a regular batch for the agricultural biogas station in Pustějov. While anaerobic digestion of ensilages is largely diffi cult due to the content of lignocellulose, biscuit meal provides a high yield of biogas or methane, respectively, thanks t...

  4. Development of high-pressure dry ice blasting method for decontamination. 4. Application test for barrel type dry ice blasting method

    Energy Technology Data Exchange (ETDEWEB)

    Ogawa, Ryuichirou; Ishijima, Noboru; Morishita, Yoshitsugu; Tanimoto, Ken-ichi [Power Reactor and Nuclear Fuel Development Corp., Oarai, Ibaraki (Japan). Oarai Engineering Center

    1997-07-01

    In order to decrease radioactivity of high-level radioactive wastes to low-level (lower than 500 {mu} Sv/h), the dry-ice blasting method has been developing. This method can decontaminate radioactive wastes up to 10{sup 2} in decontamination factor, and can minimize the secondary generated wastes. The barrel type method can decontaminate smaller solid wastes with preventing the scattering of the wastes due to blast pressure. In this work, application test was conducted to improve the decontamination capability of the barrel type method, with using the improved barrel device. Results are as follows. (1) Stirring ability of the barrel device was improved by installing plates in the barrel. Four plates with 10 mm in height were better for optimal stirring. (2) Reciprocating of the blasting nozzle stabilized decontamination capability of the barrel device. Forty per a minute in reciprocation rate of the nozzle was better. (3) Decontamination capability was examined with using test pieces coated with the cesium molybdate, which was simulating the typical contamination of radioactive waste. As a result, 80% of contamination was removed by the optimized barrel type method. (4) Dust collector was frozen within a few minutes, and exhaust flow rate was decreased by about 15%. However, by exhausting room temperature air, dust collector was unfrozen, and the flow rate could be recovered. (5) Decontamination capabilities of two types of dry ice pellets were compared. They were made by an oil hydraulic pressing or a roller pressing. Former pellet was three times as capable as latter one. (author)

  5. Study of the inclusive beauty production at CMS and construction and commissioning of the CMS pixel barrel detector

    Energy Technology Data Exchange (ETDEWEB)

    Caminada, Lea

    2012-07-01

    This thesis describes one of the first measurements made at CERN's Large Hadron Collider, the world's largest and highest-energy particle collider. The method of analysis described in the first part is applied to the first CMS collision data collected after the LHC startup in 2010 and leads to the first experimental result for the inclusive b cross section using semileptonic decays at a center of mass energy of 7 TeV. The second part of the thesis describes the building and testing of the barrel pixel detector; the author herself played an important role in its construction, commissioning and first exploitation.

  6. Algorithm and implementation of muon trigger and data transmission system for barrel-endcap overlap region of the CMS detector

    CERN Document Server

    Zabolotny, Wojciech

    2015-01-01

    The CMS experiment is currently undergoing upgrade of its trigger, including the Level-1 muon trigger. In the barrel-endcap transition region it is necessary to merge data from 3 types of detectors - RPC, DT and CSC. The Overlap Muon Track Finder (OMTF) uses the novelty approach to concentrate and process those data in an uniform manner. The paper presents the algorithm and FPGA firmware implementation of the OMTF and its data transmission system in CMS. The OMTF is subject to significant changes during optimizations based on physical simulations. Therefore a special, high level, parametrized HDL implementation is necessary.

  7. Study of the inclusive beauty production at CMS and construction and commissioning of the CMS pixel barrel detector

    International Nuclear Information System (INIS)

    This thesis describes one of the first measurements made at CERN's Large Hadron Collider, the world's largest and highest-energy particle collider. The method of analysis described in the first part is applied to the first CMS collision data collected after the LHC startup in 2010 and leads to the first experimental result for the inclusive b cross section using semileptonic decays at a center of mass energy of 7 TeV. The second part of the thesis describes the building and testing of the barrel pixel detector; the author herself played an important role in its construction, commissioning and first exploitation.

  8. Folding outer membrane proteins independently of the β-barrel assembly machinery: an assembly pathway for multimeric complexes?

    Science.gov (United States)

    Huysmans, Gerard H M

    2016-06-15

    Since the discovery of the essential role of the β-barrel assembly machinery (BAM) for the membrane insertion of outer membrane proteins (OMPs) that are unrelated in sequence, members of this universally conserved family dominate discussions on OMP assembly in bacteria, mitochondria and chloroplasts. However, several multimeric bacterial OMPs assemble independently of the catalyzing BAM-component BamA. Recent progress on this alternative pathway is reviewed here, and a model for BAM-independent assembly for multimeric OMPs is proposed in which monomer delivery to the membrane and stable prepore formation are key steps towards productive membrane insertion.

  9. 论"EB"环境中消费合同的履行——从消费者权益救济视角%Discussion on the Performance of Consumer Contract in the "EB" Environment: From the Perspective of Consumer Right Relieving

    Institute of Scientific and Technical Information of China (English)

    温晓芸

    2011-01-01

    我国相关电子商务立法的缺位是导致消费者知情权遭受损害的根本原因.鉴于"EB"环境中消费者求偿权实现的特殊性,立法要在交易后保障消费者求偿权的实现,完善"EB"环境中消费合同履行制度设计,促进我国电子商务行业的有序发展.%The absence of relevant e-commerce legislation is the root cause which result in the damage to the consumer's right to know. In view of the specificity of the realization of the consumer's right of claim, the legislation must ensure the realization of consumer's right of claim after transaction and improve the design for the performance system of consumer contract under "EB" environment, in order to promote the order development of ecommerce industry.

  10. Ebülfez Elçibeyin Yaklaşımıyla Azerbaycan İlminin Tarihi

    Directory of Open Access Journals (Sweden)

    MUHAMMET KEMALOĞLU

    2014-01-01

    Full Text Available Çağımız bilim çağıdır. Bilimin her alanında birçok araştırmalar yapılmakta, insanlar günden güne doğaya egemen olmaktadır. Bilimin önemini kavrayan uluslar, artık en basit gibi görünen sorunları bile bilimsel yöntemlerle çözümleme yoluna gitmektedirler. 21. yüzyıl, bilimsel ve akılcı düşünme becerisine sahip, araştırmacı, sorgulayıcı, bilgiyi ezberleyen değil, bilgiye ulaşabilen, teknolojiyi etkin ve verimli kullanabilen, kendisini yenileyen, insanlığın ortak değerlerini sahiplenen, yaratıcı, üretken ve yaşam boyu öğrenmeyi benimsemiş bireyler istemektedir. Azerbaycan, eski ve tarihi kültürel miraslara sahiptir. Azerbaycan'daki en eski insan yerleşimleri Taş Devri'ne kadar uzanır, bu yerleşimin bulgularına Azıh Mağarası'nda rastlanmıştır ve Kuruçay kültürü adıyla tanınır. Eski Taş Çağı ve Tunç Çağı ile ilgili kalıntılara ise Tağılar, Damcılı, Zar, Yatak-yeri adlı yerleşim merkezlerinde yer alan mağaralarda ve Leylatepe ile Saraytepe nekropollerinde ulaşılmıştır. Azerbaycan'da milattan önce dokuzuncu yüzyılda, ilk İskit yerleşimleri başladı. Azerbaycan tarihinin, özellikle de ilim tarihinin en eski dönemleri yeterince bilinmese de, burada zengin bir ilmin hem de devam eden bir ilmin varlığı kuşkusuzdur. Farklı dillerde eser veren, farklı kültürlerin etkisini taşıyan Azerbaycan Türkleri, binlerce yıllık tarihînde sayılamayacak kadar eser vermişlerdir. Azerbaycan topraklarındaki ilk siyasi yapıların, İskitler Devleti’ne götürüldüğü de düşününce, Azerbaycan'ın en eski dönemlerden beri dünyanın kültür merkezlerinden biri olarak öne çıkmaktadır. Bu gelenek ülkenin bütün tarihî boyunca devam ettirilmiştir. Bu çalışmamızda Ebülfez Elçibey ilmin önemini vurgulayarak Azerbaycan’ın geleceği için de ne anlama geldiğini anlatmıştır.

  11. IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples.

    Science.gov (United States)

    Piloto, Obdulio; Nguyen, Bao; Huso, David; Kim, Kyu-Tae; Li, Yiwen; Witte, Larry; Hicklin, Daniel J; Brown, Patrick; Small, Donald

    2006-05-01

    The class III receptor tyrosine kinase FLT3 is expressed on the blasts of >90% of patients with B-lineage acute lymphoblastic leukemias (ALL). In addition, it is expressed at extremely high levels in ALL patients with mixed lineage leukemia rearrangements or hyperdiploidy and is sometimes mutated in these same patients. In this report, we investigate the effects of treating ALL cell lines and primary samples with human anti-FLT3 monoclonal antibodies (mAb) capable of preventing binding of FLT3 ligand. In vitro studies, examining the ability of two anti-FLT3 mAbs (IMC-EB10 and IMC-NC7) to affect FLT3 activation and downstream signaling in ALL cell lines and primary blasts, yielded variable results. FLT3 phosphorylation was consistently inhibited by IMC-NC7 treatment, but in some cell lines, IMC-EB10 actually stimulated FLT3 activation, possibly as a result of antibody-mediated receptor dimerization. Through antibody-dependent, cell-mediated cytotoxicity, such an antibody could still prove efficacious against leukemia cells in vivo. In fact, IMC-EB10 treatment significantly prolonged survival and/or reduced engraftment of several ALL cell lines and primary ALL samples in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. This occurred even when IMC-EB10 treatment resulted in FLT3 activation in vitro. Moreover, fluorescence-activated cell sorting and PCR analysis of IMC-EB10-treated NOD/SCID mice surviving 150 days post-leukemic cell injection revealed that FLT3 immunotherapy reduced leukemic engraftment below the level of detection in these assays (IMC-EB10 treatment did not select for resistant cells, because cells surviving IMC-EB10 treatment remain sensitive to IMC-EB10 cytotoxicity upon retransplantation. In vivo studies involving either partial depletion or activation of natural killer (NK) cells show that most of the cytotoxic effect of IMC-EB10 is mediated through NK cells. Therefore, such an antibody, either naked or conjugated to radioactive

  12. Design studies for a tracking upgrade of the Crystal Barrel experiment at ELSA and installation of tracking test bench

    International Nuclear Information System (INIS)

    Ever since mankind was interested in the understanding of the universe and especially the matter in it. The fundamental building blocks of matter seem to be quarks and gluons, whose interactions are investigated in hadron physics. To study this strong interaction different experimental approaches can be used. One way is to do spectroscopy similar to atomic physics. The Crystal Barrel experiment at ELSA performs spectroscopy of nucleons to learn more about the strong interaction. A major improvement of this experimental setup will be the introducing of charged particle tracking as it is shown in this thesis. Different detector concepts are discussed concerning feasibility, material budget and especially momentum resolution. It turns out that a Time Projection Chamber (TPC) is the optimal solution. Then it is shown how a prototype TPC is tested using a newly installed tracking test bench with an electron beam, and obtained results are presented. The design of the final TPC and its integration into the Crystal Barrel experiment are discussed as well as methods to calibrate the detector. (orig.)

  13. Layer- and column-specific knockout of NMDA receptors in pyramidal neurons of the mouse barrel cortex.

    Directory of Open Access Journals (Sweden)

    Rachel Aronoff

    2007-11-01

    Full Text Available Viral vectors injected into the mouse brain offer the possibility for localized genetic modifications in a highly controlled manner. Lentivector injection into mouse neocortex transduces cells within a diameter of approximately 200µm, which closely matches the lateral scale of a column in barrel cortex. The depth and volume of the injection determines which cortical layer is transduced. Furthermore, transduced gene expression from the lentivector can be limited to predominantly pyramidal neurons by using a 1.3kb fragment of the αCaMKII promoter. This technique therefore allows genetic manipulation of a specific cell type in defined columns and layers of the neocortex. By expressing Cre recombinase from such a lentivector in gene-targeted mice carrying a floxed gene, highly specific genetic lesions can be induced. Here, we demonstrate the utility of this approach by specifically knocking out NMDA receptors (NMDARs in pyramidal neurons in the somatosensory barrel cortex of gene-targeted mice carrying floxed NMDAR 1 genes. Neurons transduced with lentivector encoding GFP and Cre recombinase exhibit not only reductions in NMDAR 1 mRNA levels, but reduced NMDAR-dependent currents and pairing-induced synaptic potentiation. This technique for knockout of NMDARs in a cell type, column- and layer-specific manner in the mouse somatosensory cortex may help further our understanding of the functional roles of NMDARs in vivo during sensory perception and learning.

  14. Design studies for a tracking upgrade of the Crystal Barrel experiment at ELSA and installation of tracking test bench

    Energy Technology Data Exchange (ETDEWEB)

    Winnebeck, Alexander

    2009-12-17

    Ever since mankind was interested in the understanding of the universe and especially the matter in it. The fundamental building blocks of matter seem to be quarks and gluons, whose interactions are investigated in hadron physics. To study this strong interaction different experimental approaches can be used. One way is to do spectroscopy similar to atomic physics. The Crystal Barrel experiment at ELSA performs spectroscopy of nucleons to learn more about the strong interaction. A major improvement of this experimental setup will be the introducing of charged particle tracking as it is shown in this thesis. Different detector concepts are discussed concerning feasibility, material budget and especially momentum resolution. It turns out that a Time Projection Chamber (TPC) is the optimal solution. Then it is shown how a prototype TPC is tested using a newly installed tracking test bench with an electron beam, and obtained results are presented. The design of the final TPC and its integration into the Crystal Barrel experiment are discussed as well as methods to calibrate the detector. (orig.)

  15. Fake Populism or Real Populism: Pork Barrel Policy as Political Corruption in House of Representative During 2009-2013

    Directory of Open Access Journals (Sweden)

    Wasisto Raharjo Jati

    2013-08-01

    Full Text Available This article aims to analyze the practice of pork barrel politics in the level of Indonesia legislature tiers and its political management campaign. Since 2004, electoral democracy already delegate to the common people to chosen their representation directly through general election in the level executive and legislative. Those conditions oblige politician and political parties to approaching the commons in order to obtain their vote and popularize both actors into public. The paradigm of research is a pork barrel politics. This paradigm supports to understand and analyze the corruption symptoms i.e. politico corruption in legislative tier and electoral-corruption in political-campaign which become chronic problems in this country. Result of research has showed populism is pivotal key which triggered up politician and parties to corruption in order to persist their political tenure and funding their political cost in pursue to re-elect again in second office terms. No matter their corruption practice that implicate to budgeting fraud. Both actors take political favor to disguise within social aids following the governmental policy, so that, they hindered from corruption accusation. Finally, this paper wants to recommend legal improvement into our budgeting cycle wherein there are public participation to watch it and moral improvement to politician and parties to reducing their corruption if they wants to become truly populist politician figure into public.

  16. Revisiting the membrane interaction mechanism of a membrane-damaging β-barrel pore-forming toxin Vibrio cholerae cytolysin.

    Science.gov (United States)

    Rai, Anand Kumar; Chattopadhyay, Kausik

    2015-09-01

    Vibrio cholerae cytolysin (VCC) permeabilizes target cell membranes by forming transmembrane oligomeric β-barrel pores. VCC has been shown to associate with the target membranes via amphipathicity-driven spontaneous partitioning into the membrane environment. More specific interaction(s) of VCC with the membrane components have also been documented. In particular, specific binding of VCC with the membrane lipid components is believed to play a crucial role in determining the efficacy of the pore-formation process. However, the structural basis and the functional implications of the VCC interaction with the membrane lipids remain unclear. Here we show that the distinct loop sequences within the membrane-proximal region of VCC play critical roles to determine the functional interactions of the toxin with the membrane lipids. Alterations of the loop sequences via structure-guided mutagenesis allow amphipathicity-driven partitioning of VCC to the membrane lipid bilayer. Alterations of the loop sequences, however, block specific interactions of VCC with the membrane lipids and abort the oligomerization, membrane insertion, pore-formation and cytotoxic activity of the toxin. Present study identifies the structural signatures in VCC implicated for its functional interactions with the membrane lipid components, a process that presumably acts to drive the subsequent steps of the oligomeric β-barrel pore-formation and cytotoxic responses.

  17. Perilous proximity: Does the Janzen-Connell hypothesis explain the distribution of giant barrel sponges on a Florida coral reef?

    Science.gov (United States)

    Deignan, Lindsey K.; Pawlik, Joseph R.

    2015-06-01

    One popular concept used to explain the high biodiversity of some ecosystems is the Janzen-Connell hypothesis, which states that the distribution of conspecifics is controlled by species-specific pathogens or predators that are attracted to adults or to their reproductive output. The distribution of the affected species would then display a distinct pattern, with survivorship increasing at greater distance from the conspecific adult (negative density dependence), leaving a vacant area around the adult where other species can survive. The giant barrel sponge, Xestospongia muta, is an abundant and long-lived sponge on Caribbean coral reefs that is actively grazed by sponge-eating fishes and is susceptible to disease. We tested the Janzen-Connell hypothesis on barrel sponges on Conch Reef, Florida, by examining their distribution as a function of size using spatial point pattern analyses. Clark and Evans tests and a series of Ripley's K function analyses revealed no consistent distribution pattern, with most analyses resulting in a random pattern of sponge distribution. While predation by sponge-eating fishes has recently been discovered to structure sponge communities on reefs across the Caribbean, these top-down effects do not translate to spatial distributions of X. muta that support Janzen-Connell predictions.

  18. Outer membrane β-barrel protein folding is physically controlled by periplasmic lipid head groups and BamA.

    Science.gov (United States)

    Gessmann, Dennis; Chung, Yong Hee; Danoff, Emily J; Plummer, Ashlee M; Sandlin, Clifford W; Zaccai, Nathan R; Fleming, Karen G

    2014-04-22

    Outer membrane β-barrel proteins (OMPs) are crucial for numerous cellular processes in prokaryotes and eukaryotes. Despite extensive studies on OMP biogenesis, it is unclear why OMPs require assembly machineries to fold into their native outer membranes, as they are capable of folding quickly and efficiently through an intrinsic folding pathway in vitro. By investigating the folding of several bacterial OMPs using membranes with naturally occurring Escherichia coli lipids, we show that phosphoethanolamine and phosphoglycerol head groups impose a kinetic barrier to OMP folding. The kinetic retardation of OMP folding places a strong negative pressure against spontaneous incorporation of OMPs into inner bacterial membranes, which would dissipate the proton motive force and undoubtedly kill bacteria. We further show that prefolded β-barrel assembly machinery subunit A (BamA), the evolutionarily conserved, central subunit of the BAM complex, accelerates OMP folding by lowering the kinetic barrier imposed by phosphoethanolamine head groups. Our results suggest that OMP assembly machineries are required in vivo to enable physical control over the spontaneously occurring OMP folding reaction in the periplasm. Mechanistic studies further allowed us to derive a model for BamA function, which explains how OMP assembly can be conserved between prokaryotes and eukaryotes.

  19. Single-photon sensitive fast ebCMOS camera system for multiple-target tracking of single fluorophores: application to nano-biophotonics

    Science.gov (United States)

    Cajgfinger, Thomas; Chabanat, Eric; Dominjon, Agnes; Doan, Quang T.; Guerin, Cyrille; Houles, Julien; Barbier, Remi

    2011-03-01

    Nano-biophotonics applications will benefit from new fluorescent microscopy methods based essentially on super-resolution techniques (beyond the diffraction limit) on large biological structures (membranes) with fast frame rate (1000 Hz). This trend tends to push the photon detectors to the single-photon counting regime and the camera acquisition system to real time dynamic multiple-target tracing. The LUSIPHER prototype presented in this paper aims to give a different approach than those of Electron Multiplied CCD (EMCCD) technology and try to answer to the stringent demands of the new nano-biophotonics imaging techniques. The electron bombarded CMOS (ebCMOS) device has the potential to respond to this challenge, thanks to the linear gain of the accelerating high voltage of the photo-cathode, to the possible ultra fast frame rate of CMOS sensors and to the single-photon sensitivity. We produced a camera system based on a 640 kPixels ebCMOS with its acquisition system. The proof of concept for single-photon based tracking for multiple single-emitters is the main result of this paper.

  20. Reconstruction of a complicated adjacent non-union of the radius and ulna using a free vascularised double-barrel fibula graft.

    Science.gov (United States)

    Frary, Evan Charles; Sandager Petersen, Søren; Skov, Ole; Sørensen, Jens Ahm

    2016-01-01

    While the free vascularised double-barrel fibula flap has been traditionally used in the reconstruction of defects in the long bones of the lower extremities, the advantages of this type of graft can also be seen in the treatment of adjacent radial and ulnar non-unions of the forearm. The main advantage of the double-barrel fibula flap in treatment of antebrachial non-unions is that it allows for the simultaneous anatomical reconstruction of the radius and the ulna while maximising forearm functionality. In contrast to other procedures, this tailored graft also helps preserve pronation and supination of the forearm. In this article, we chronicle a case in which a microvascular osteomyocutaneous double-barrel fibula flap was used to concurrently reconstruct the radius and ulna of a patient with a severe antebrachial non-union. PMID:27170603