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Sample records for barbiturate coma therapy

  1. Evolution of Cerebral Atrophy in a Patient with Super Refractory Status Epilepticus Treated with Barbiturate Coma

    Science.gov (United States)

    George, Pravin; Nattanmai, Premkumar; Ahrens, Christine; Hantus, Stephen; Sarwal, Aarti

    2017-01-01

    Introduction. Status epilepticus is associated with neuronal breakdown. Radiological sequelae of status epilepticus include diffusion weighted abnormalities and T2/FLAIR cortical hyperintensities corresponding to the epileptogenic cortex. However, progressive generalized cerebral atrophy from status epilepticus is underrecognized and may be related to neuronal death. We present here a case of diffuse cerebral atrophy that developed during the course of super refractory status epilepticus management despite prolonged barbiturate coma. Methods. Case report and review of the literature. Case. A 19-year-old male with a prior history of epilepsy presented with focal clonic seizures. His seizures were refractory to multiple anticonvulsants and eventually required pentobarbital coma for 62 days and midazolam coma for 33 days. Serial brain magnetic resonance imaging (MRI) showed development of cerebral atrophy at 31 days after admission to our facility and progression of the atrophy at 136 days after admission. Conclusion. This case highlights the development and progression of generalized cerebral atrophy in super refractory status epilepticus. The cerebral atrophy was noticeable at 31 days after admission at our facility which emphasizes the urgency of definitive treatment in patients who present with super refractory status epilepticus. Further research into direct effects of therapeutic coma is warranted. PMID:28182114

  2. Evolution of Cerebral Atrophy in a Patient with Super Refractory Status Epilepticus Treated with Barbiturate Coma

    Directory of Open Access Journals (Sweden)

    Christopher R. Newey

    2017-01-01

    Full Text Available Introduction. Status epilepticus is associated with neuronal breakdown. Radiological sequelae of status epilepticus include diffusion weighted abnormalities and T2/FLAIR cortical hyperintensities corresponding to the epileptogenic cortex. However, progressive generalized cerebral atrophy from status epilepticus is underrecognized and may be related to neuronal death. We present here a case of diffuse cerebral atrophy that developed during the course of super refractory status epilepticus management despite prolonged barbiturate coma. Methods. Case report and review of the literature. Case. A 19-year-old male with a prior history of epilepsy presented with focal clonic seizures. His seizures were refractory to multiple anticonvulsants and eventually required pentobarbital coma for 62 days and midazolam coma for 33 days. Serial brain magnetic resonance imaging (MRI showed development of cerebral atrophy at 31 days after admission to our facility and progression of the atrophy at 136 days after admission. Conclusion. This case highlights the development and progression of generalized cerebral atrophy in super refractory status epilepticus. The cerebral atrophy was noticeable at 31 days after admission at our facility which emphasizes the urgency of definitive treatment in patients who present with super refractory status epilepticus. Further research into direct effects of therapeutic coma is warranted.

  3. The Clinical Curative Effect and Prognosis of Barbiturate Coma Therapy in Severe Head Trauma%巴比妥昏迷疗法在重型颅脑创伤中的临床疗效及预后研究分析

    Institute of Scientific and Technical Information of China (English)

    高华

    2015-01-01

    Objective:To summarize the barbiturate coma therapy in clinical curative effect and prognosis of severe head trauma. Method:82 patients of severe craniocerebral trauma were selected in our hospital from February 2013 to August 2014 during the period of accepted the diagnosis and treatment,and randomly divided into two groups, 41 cases in each group.The control group were underwent routine therapy,while the experimental group was treated barbiturate coma therapy,at the same time,two groups’ treatment and prognosis were contrasted and analyzed. Result:Two groups 24 hours and 48 hours after treatment gived the real-time monitoring,the test results showed that the two groups in the cavity of cerebrospinal fluid pressure and cerebral blood flow and other clinical indicators were dropped. Compared with control group,the experimental group patients clinical index fell more,the difference was statistically significant(P<0.05).Conclusion:The clinical barbiturate coma therapy on the clinical curative effect and prognosis of severe head trauma effect is significant,in addition to being able to control the cerebrospinal fluid pressure in patients with cranial cavity,maximize the cerebral perfusion,at the same time also can improve the patients’ symptoms of cerebral ischemia or hypoxia,plays a comprehensive protection for the brain,thus it has the high feasibility and is worth promoting.%目的:总结巴比妥昏迷疗法在重型颅脑创伤中的临床疗效及预后情况。方法:本次研究资料选自2013年2月-2014年8月期间在本院接受诊治的82例重型颅脑创伤患者,将其随机分为两组,每组各41例患者。对照组接受常规治疗,而试验组则接受巴比妥昏迷疗法,对比及分析两组患者的治疗情况以及预后情况。结果:两组患者治疗24、48 h后给予进行实时监测,其检测结果表明两组患者在颅腔内脑脊液的压力、脑血流量等临床指标方面均有所下降,且与对照

  4. Coma

    Science.gov (United States)

    ... state of unconsciousness. Persistent vegetative state is not brain-death. An individual in a state of coma is ... state of unconsciousness. Persistent vegetative state is not brain-death. An individual in a state of coma is ...

  5. Coma blisters sans coma.

    Science.gov (United States)

    Heinisch, Silke; Loosemore, Michael; Cusack, Carrie A; Allen, Herbert B

    2012-09-01

    Coma blisters (CBs) are self-limited lesions that occur in regions of pressure during unconscious states classically induced by barbiturates. We report a case of CBs sans coma that were histologically confirmed in a 41-year-old woman who developed multiple tense abdominal bullae with surrounding erythema following a transatlantic flight. Interestingly, the patient was fully conscious and denied medication use or history of medical conditions. A clinical diagnosis of CBs was confirmed by histopathologic findings of eccrine gland necrosis, a hallmark of these bulIous lesions.

  6. Influence of hypothermia, barbiturate therapy, and intracranial pressure monitoring on morbidity and mortality after near-drowning.

    Science.gov (United States)

    Bohn, D J; Biggar, W D; Smith, C R; Conn, A W; Barker, G A

    1986-06-01

    We retrospectively evaluated the clinical and pathologic effects of hypothermia and high-dose barbiturate therapy on hypoxic/ischemic cerebral injury after near-drowning in children. Of 40 near-drowned patients admitted to the ICU, 13 died, seven had permanent cerebral damage, and 20 survived. Twenty-four patients (group 1) were treated with a regime of hyperventilation, hypothermia, and high-dose phenobarbitone while intracranial pressure (ICP) was continuously monitored. Of ten who died in this group, three were diagnosed as having cerebral death shortly after admission; autopsy revealed severe cerebral edema with herniation. The remaining seven nonsurvivors had severe cerebral hypoxia without raised ICP and had the features of severe adult respiratory distress syndrome and hypoxic/ischemic damage to other organs. Six of these seven patients developed septicemia which was invariably associated with a profound neutropenia. Sixteen patients (group 2) were treated with a similar protocol but without hypothermia. Three of these patients died but only one developed septicemia. Neutropenia after resuscitation from near-drowning seemed to indicate a poor prognosis; the mean polymorphonuclear leukocyte count in nonsurvivors (1.9 +/- 0.5 X 10(9) cell/L) was significantly (p less than .01) lower than that in survivors (6.4 +/- 1.1 X 10(9) cell/L). Hypothermia was associated with a decreased number of circulating PMNs but did not increase the number of neurologically intact survivors. Similarly, although barbiturates may control ICP, their use did not improve outcome. Because severe cerebral edema and herniation after near-drowning is usually associated with irreversible brain damage, measures to control brain swelling such as hypothermia and barbiturates will be of little benefit.(ABSTRACT TRUNCATED AT 250 WORDS)

  7. Coma blisters in two postoperative patients.

    Science.gov (United States)

    Chacon, Anna H; Farooq, Uzma; Choudhary, Sonal; Yin, Natalie; Nolan, Bridgit; Shiman, Michael; Milikowski, Clara; Izakovic, Jan; Elgart, George W

    2013-05-01

    Coma blisters are self-limited cutaneous bullae that occur in the setting of loss of consciousness because of a drug, illness, or accident, with the most common settings being barbiturate overdose and neurological disorders. The etiology behind coma blisters is poorly understood and is not related to underlying infections or autoimmune conditions. The clinical presentation consists of bullae, erosions, and violaceous plaques usually involving sites of pressure. The skin lesions usually occur within 48-72 hours of the start of a coma and resolve within 2-4 weeks. We present one case of a 5-month-old infant with severe valvular disease who required surgical repair. He was placed on extra corporeal membrane oxygenation and developed multiple tense coma blisters during the course of therapy. Skin biopsy revealed a noninflammatory subepidermal blister with necrosis of the overlying epidermis and necrosis of the eccrine ducts. We also present a second case of an 18-year-old female patient who underwent surgical resection of a benign mandibular tumor. She subsequently developed bullae on both arms 4 days after surgery. The skin biopsy showed a necrotic epidermis, a subepidermal blister, and diffuse necrosis of the eccrine coils.

  8. [On the history of barbiturates].

    Science.gov (United States)

    Norn, Svend; Permin, Henrik; Kruse, Edith; Kruse, Poul R

    2015-01-01

    Throughout the history of humanity, numerous therapeutic agents have been employed for their sedative and hypnotic properties such as opium, henbane (Hyoscyamus niger) and deadly nightshade (Atropa belladonna), but also alcohol and wine. In the 19th century potassium bromide was introduced as a sedative - and antiepileptic drug and chloral hydrate as sedative-hypnotics. A new era was reached by the introduction of barbiturates. The story started with the chemist Adolf von Baeyer. His breakthrough in the synthesis of new agents as barbituric acid and indigo and his education of young chemists was of great importance for the science of organic chemistry and the development of the dye and medicine industry in the late 19th century. The next important step was the development of barbiturates. The pioneers were Josef von Mering and Emil Fischer. Using the Grimaux-method they synthesized various barbiturates. It was von Mering who got the idea of introducing ethyl groups in the inactive barbituric acid to obtain sedatives, but the synthesis was succeeded by the chemist Emil Fischer. Experiments with dogs clearly showed sedative and hypnotic effect of the barbiturates and the oral administration of barbital (Veronal) confirmed the effect in humans. Barbital was commercialized in 1903 and in 1911 phenobarbital (Luminal) was introduced in the clinic, and this drug showed hypnotic and antiepileptic effects. Thereafter a lot of new barbiturates appeared. Dangerous properties of the drugs were recognized as abuse, addiction, and poisoning. An optimum treatment of acute barbiturate intoxication was obtained by the "Scandinavian method", which was developed in the Poison Centre of the Bispebjerg Hospital in Copenhagen. The centre was established by Carl Clemmesen in 1949 and the intensive care treatment reduced the mortality of the admitted persons from 20% to less than 2%. To-day only a few barbiturates are used in connection with anaesthesia and for the treatment of epilepsy

  9. Myxedema coma.

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    Wartofsky, Leonard

    2006-12-01

    Myxedema coma is the term given to the most severe presentation of profound hypothyroidism and is often fatal in spite of therapy. Decompensation of the hypothyroid patient into a coma may be precipitated by a number of drugs, systemic illnesses (eg, pneumonia), and other causes. It typically presents in older women in the winter months and is associated with signs of hypothyroidism, hypothermia, hyponatremia, hypercarbia, and hypoxemia. Treatment must be initiated promptly in an intensive care unit setting. Although thyroid hormone therapy is critical to survival, it remains uncertain whether it should be administered as thyroxine, triiodothyronine, or both. Adjunctive measures, such as ventilation, warming, fluids, antibiotics, pressors, and corticosteroids, may be essential for survival.

  10. Extracorporeal treatment for barbiturate poisoning

    DEFF Research Database (Denmark)

    Mactier, Robert; Laliberté, Martin; Mardini, Joelle;

    2014-01-01

    The EXTRIP (Extracorporeal Treatments in Poisoning) Workgroup conducted a systematic review of barbiturate poisoning using a standardized evidence-based process to provide recommendations on the use of extracorporeal treatment (ECTR) in patients with barbiturate poisoning. The authors reviewed all...... articles, extracted data, summarized key findings, and proposed structured voting statements following a predetermined format. A 2-round modified Delphi method was used to reach a consensus on voting statements, and the RAND/UCLA Appropriateness Method was used to quantify disagreement. 617 articles met...... depression necessitating mechanical ventilation, shock, persistent toxicity, or increasing or persistently elevated serum barbiturate concentrations despite treatment with multiple-dose activated charcoal. (3) Intermittent hemodialysis is the preferred mode of ECTR, and multiple-dose activated charcoal...

  11. Coma blisters in 2 children on anticonvulsant medication.

    Science.gov (United States)

    Basu, Anna; Brown, Sara; Kirkham, Nigel; Ramesh, Venkateswaran; Leech, Suzy; Devlin, Anita

    2009-08-01

    Blister formation and eccrine sweat gland necrosis have been recognized to occur in states of impaired consciousness and were first reported following barbiturate intoxication. Their etiology is complex and cannot simply be explained by pressure effects. Now that barbiturates are less frequently used, clinicians are likely to be less aware of the phenomenon of coma blister formation; however, newer drugs have also been associated with the occurrence of coma blisters. We describe 2 new associations of coma blisters and anticonvulsants in children. In the first child, blisters recurred on multiple occasions along with obtundation and edema. Our aims are to alert clinicians to the occurrence of coma blisters in children sedated on anticonvulsant medications and to report the new finding of recurrent coma blisters.

  12. The impact of physical therapy in patients with severe traumatic brain injury during acute and post-acute rehabilitation according to coma duration.

    Science.gov (United States)

    Lendraitienė, Eglė; Petruševičienė, Daiva; Savickas, Raimondas; Žemaitienė, Ieva; Mingaila, Sigitas

    2016-07-01

    [Purpose] The aim of study was to evaluate the impact of physical therapy on the recovery of motor and mental status in patients who sustained a severe traumatic brain injury, according to coma duration in acute and post-acute rehabilitation. [Subjects and Methods] The study population comprised patients with levels of consciousness ranging from 3 to 8 according to Glasgow Coma Scale score. The patients were divided into 2 groups based on coma duration as follows: group 1, those who were in a coma up to 1 week, and group 2, those who were in a coma for more than 2 weeks. The recovery of the patients' motor function was evaluated according to the Motor Assessment Scale and the recovery of mental status according to the Mini-Mental State Examination. [Results] The evaluation of motor and mental status recovery revealed that the patients who were in a coma up to 1 week recovered significantly better after physical therapy during the acute rehabilitation than those who were in a coma for longer than 2 weeks. [Conclusion] The recovery of motor and mental status of the patients in acute rehabilitation was significantly better for those in a coma for a shorter period.

  13. Barbiturates for acute traumatic brain injury.

    OpenAIRE

    Roberts, I.; Sydenham, E

    2012-01-01

    BACKGROUND: Raised intracranial pressure (ICP) is an important complication of severe brain injury, and is associated with high mortality. Barbiturates are believed to reduce ICP by suppressing cerebral metabolism, thus reducing cerebral metabolic demands and cerebral blood volume. However, barbiturates also reduce blood pressure and may, therefore, adversely effect cerebral perfusion pressure. OBJECTIVES: To assess the effects of barbiturates in reducing mortality, disability and raised ICP ...

  14. Hyperosmolar nonketotic hyperglycemic coma induced by methylprednisolone pulse therapy for acute rejection after liver transplantation: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Zhou J

    2014-12-01

    Full Text Available Jian Zhou,* Weiqiang Ju,* Xiaopeng Yuan, Xiaofeng Zhu, Dongping Wang, Xiaoshun HeOrgan Transplant Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China *These authors contributed equally to this work Abstract: Hyperosmolar nonketotic hyperglycemic coma (HNKHC is a serious, rare complication induced by methylprednisolone (MP pulse therapy for acute rejection after orthotopic liver transplantation (OLT. Herein, we report an unusual case of a 58-year-old woman who experienced acute rejection at 30 months after OLT, only one case in which HNKHC resulted in MP pulse therapy for acute rejection in all 913 recipients in our center. The general morbidity of HNKHC was 1.09‰ in this study. HNKHC is characterized by rapid onset, rapid progression, and a lack of specific clinical manifestations. High-dose MP management was a clear risk factor. The principle of treatment included rapid rehydration, low-dose insulin infusion, and correcting disorders of electrolytes and acidosis. In conclusion, clinicians considering MP pulse therapy after OLT should be alert to the occurrence of HNKHC. Keywords: liver transplantation, complications, hyperosmolar nonketotic hyperglycemic coma, methylprednisolone pulse therapy, principle of treatment

  15. Coma blisters in children: case report and review of the literature.

    Science.gov (United States)

    Bosco, Laura; Schena, Donatella; Colato, Chiara; Biban, Paolo; Girolomoni, Giampiero

    2013-12-01

    Coma-induced blisters is a rare condition associated with prolonged impairment of conscious level, which is relatively well-known in adults following overdose with barbiturates. However, it has been very rarely described in children. A case of coma-bullae occurring in an 11-year-old child with meningoencephalitis is herein reported. The bullous lesions occurred on the limbs and trunks, and evolved into necrotic ulcers in a few days. No correlation with any drug overdosage was found. A skin biopsy revealed epidermal and eccrine sweat gland necrosis with abundant neutrophils, and thrombosis of the vessels in the lower dermis. A comprehensive review of the literature showed that only 5 cases of coma-bullae in children have been published so far. Coma blistering resolves spontaneously within days or weeks. Diagnosis of coma-bullae may require careful clinical-pathologic correlation to exclude other blistering diseases in children.

  16. Resuscitation therapy for traumatic brain injury-induced coma in rats:mechanisms of median nerve electrical stimulation

    Institute of Scientific and Technical Information of China (English)

    Zhen Feng; Ying-jun Zhong; Liang Wang; Tian-qi Wei

    2015-01-01

    In this study, rats were put into traumatic brain injury-induced coma and treated with median nerve electrical stimulation. We explored the wake-promoting effect, and possible mechanisms, of median nerve electrical stimulation. Electrical stimulation upregulated the expression levels of orexin-A and its receptor OX1R in the rat prefrontal cortex. Orexin-A expression gradually in-creased with increasing stimulation, while OX1R expression reached a peak at 12 hours and then decreased. In addition, after the OX1R antagonist, SB334867, was injected into the brain of rats after traumatic brain injury, fewer rats were restored to consciousness, and orexin-A and OXIR expression in the prefrontal cortex was downregulated. Our ifndings indicate that median nerve electrical stimulation induced an up-regulation of orexin-A and OX1R expression in the pre-frontal cortex of traumatic brain injury-induced coma rats, which may be a potential mechanism involved in the wake-promoting effects of median nerve electrical stimulation.

  17. Resuscitation therapy for traumatic brain injury-induced coma in rats: mechanisms of median nerve electrical stimulation

    Directory of Open Access Journals (Sweden)

    Zhen Feng

    2015-01-01

    Full Text Available In this study, rats were put into traumatic brain injury-induced coma and treated with median nerve electrical stimulation. We explored the wake-promoting effect, and possible mechanisms, of median nerve electrical stimulation. Electrical stimulation upregulated the expression levels of orexin-A and its receptor OX1R in the rat prefrontal cortex. Orexin-A expression gradually increased with increasing stimulation, while OX1R expression reached a peak at 12 hours and then decreased. In addition, after the OX1R antagonist, SB334867, was injected into the brain of rats after traumatic brain injury, fewer rats were restored to consciousness, and orexin-A and OXIR expression in the prefrontal cortex was downregulated. Our findings indicate that median nerve electrical stimulation induced an up-regulation of orexin-A and OX1R expression in the prefrontal cortex of traumatic brain injury-induced coma rats, which may be a potential mechanism involved in the wake-promoting effects of median nerve electrical stimulation.

  18. Coma / Vegetative State

    Science.gov (United States)

    ... a coma? A coma is a profound or deep state of unconsciousness (consciousness being the awareness of the ... opening or making sounds) than a person in deep coma. Characteristics of the vegetative state include: Return of a sleep-wake cycle with ...

  19. EEG and Coma.

    Science.gov (United States)

    Ardeshna, Nikesh I

    2016-03-01

    Coma is defined as a state of extreme unresponsiveness, in which a person exhibits no voluntary movement or behavior even to painful stimuli. The utilization of EEG for patients in coma has increased dramatically over the last few years. In fact, many institutions have set protocols for continuous EEG (cEEG) monitoring for patients in coma due to potential causes such as subarachnoid hemorrhage or cardiac arrest. Consequently, EEG plays an important role in diagnosis, managenent, and in some cases even prognosis of coma patients.

  20. [Coma in France today].

    Science.gov (United States)

    Do, Chung Hi

    2015-01-01

    Comas result from acute life-threatening neurological failure. To understand coma, it is firstly necessary to define it, to cite the aetiologies and their epidemiology and to describe the chronic disorders of consciousness. It is also important to address the challenges and principles of treatment during the acute phase.

  1. Anions in Cometary Comae

    Science.gov (United States)

    Charnley, Steven B.

    2011-01-01

    The presence of negative ions (anions) in cometary comae is known from Giotto mass spectrometry of IP/Halley. The anions 0-, OH-, C-, CH- and CN- have been detected, as well as unidentified anions with masses 22-65 and 85-110 amu (Chaizy et al. 1991). Organic molecular anions are known to have a significant impact on the charge balance of interstellar clouds and circumstellar envelopes and have been shown to act as catalysts for the gas-phase synthesis of larger hydrocarbon molecules in the ISM, but their importance in cometary comae has not yet been explored. We present details of the first attempt to model the chemistry of anions in cometary comae. Based on the combined chemical and hydro dynamical model of Rodgers & Charnley (2002), we investigate the role of large carbon-chain anions in cometary coma chemistry. We calculate the effects of these anions on coma thermodynamics, charge balance and examine their impact on molecule formation.

  2. What Is a Coma?

    Science.gov (United States)

    ... Quizzes Kids' Dictionary of Medical Words En Español What Other Kids Are Reading Video: Am I Normal? ( ... Emergency Room? What Happens in the Operating Room? What Is a Coma? KidsHealth > For Kids > What Is ...

  3. Application of thermoresponsive HPLC to forensic toxicology: determination of barbiturates in human urine

    OpenAIRE

    Kanno, Sanae; Watanabe, Kanako; HIRANO, SEISHIRO; Yamagishi, Itaru; Gonmori, Kunio; Minakata, Kayoko; Suzuki, Osamu

    2009-01-01

    A high-performance liquid chromatography (HPLC) method has been developed for the assays of five barbiturates in human urine using a new thermoresponsive polymer separation column, which is composed of N-isopropylacrylamide polymer. According to elevating the column temperature from 10 ℃ to 50 ℃, five barbiturates, such as metharbital, primidone, phenobarbital, mephobarbital and pentobarbital, became well separated by this method. Five barbiturates showed good linearity in the range of 0.2-10...

  4. PPL catalyzed four-component PASE synthesis of 5-monosubstituted barbiturates: Structure and pharmacological properties.

    Science.gov (United States)

    Bihani, Manisha; Bora, Pranjal P; Verma, Alakesh K; Baruah, Reshita; Boruah, Hari Prasanna Deka; Bez, Ghanashyam

    2015-12-15

    Enzymatic four-component reactions are very rare although three-component enzymatic promiscuous reactions are widely reported. Herein, we report an efficient PASE protocol for the synthesis of potentially lipophilic zwitterionic 5-monosubstituted barbiturates by four component reaction of mixture of ethyl acetoacetate, hydrazine hydrate, aldehyde and barbituric acid in ethanol at room temperature. Seven different lipases were screened for their promiscuous activity towards the synthesis of 5-monosubstituted barbiturates and the lipase from porcine pancreas (PPL) found to give optimum efficiency. The zwitterionic 5-monosubstituted barbiturates with pyrazolyl ring showed promising pharmacological activity upon screening for antibacterial and apoptotic properties.

  5. Capturing the Coma

    Science.gov (United States)

    2005-01-01

    This image shows comet Tempel 1, as seen by the Deep Impact spacecraft on June 21, 2005. It was taken using the clear filter of the spacecraft's medium resolution imager camera. The spacecraft was 11,564,081.7 kilometers (7,185,920 miles) away from the comet. Twelve images were combined together, and a logarithmic stretch was applied to enhance the coma of the comet.

  6. Coma cluster of galaxies

    Science.gov (United States)

    1999-01-01

    Atlas Image mosaic, covering 34' x 34' on the sky, of the Coma cluster, aka Abell 1656. This is a particularly rich cluster of individual galaxies (over 1000 members), most prominently the two giant ellipticals, NGC 4874 (right) and NGC 4889 (left). The remaining members are mostly smaller ellipticals, but spiral galaxies are also evident in the 2MASS image. The cluster is seen toward the constellation Coma Berenices, but is actually at a distance of about 100 Mpc (330 million light years, or a redshift of 0.023) from us. At this distance, the cluster is in what is known as the 'Hubble flow,' or the overall expansion of the Universe. As such, astronomers can measure the Hubble Constant, or the universal expansion rate, based on the distance to this cluster. Large, rich clusters, such as Coma, allow astronomers to measure the 'missing mass,' i.e., the matter in the cluster that we cannot see, since it gravitationally influences the motions of the member galaxies within the cluster. The near-infrared maps the overall luminous mass content of the member galaxies, since the light at these wavelengths is dominated by the more numerous older stellar populations. Galaxies, as seen by 2MASS, look fairly smooth and homogeneous, as can be seen from the Hubble 'tuning fork' diagram of near-infrared galaxy morphology. Image mosaic by S. Van Dyk (IPAC).

  7. [Treatment of head injury coma with prolonged pentobarbital anaesthesia (author's transl)].

    Science.gov (United States)

    Artru, F; Guerin, J M; Latarjet, J; Deleuze, R

    1981-04-11

    Forty-five patients in deep coma resulting from head injury were treated with pentobarbital in doses adjusted to maintain serum barbiturate levels between 15 and 25 mg/l and short burst suppression phases on EEG. Brain death occurred in 20%. The overall mortality rate was 60%, no death being attributable to treatment; 24% of the patients were able to resume active life. Patients with non-reactive pupils during the early phase of coma were compared with patients of similar ages and neurological symptoms non treated with pentobarbital. In treated patients the incidence of brain death was reduced by 50% and the mortality rate by 25% (p less than 0.05), without increase in deaths from intercurrent complications and in severe sequelae among survivors.

  8. Intermediates of Krebs cycle correct the depression of the whole body oxygen consumption and lethal cooling in barbiturate poisoning in rat.

    Science.gov (United States)

    Ivnitsky, Jury Ju; Schäfer, Timur V; Malakhovsky, Vladimir N; Rejniuk, Vladimir L

    2004-10-01

    Rats poisoned with one LD50 of thiopental or amytal are shown to increase oxygen consumption when intraperitoneally given sucinate, malate, citrate, alpha-ketoglutarate, dimethylsuccinate or glutamate (the Krebs cycle intermediates or their precursors) but not when given glucose, pyruvate, acetate, benzoate or nicotinate (energy substrates of other metabolic stages etc). Survival was increased with succinate or malate from control groups, which ranged from 30-83% to 87-100%. These effects were unrelated to respiratory depression or hypoxia as judged by little or no effect of succinate on ventilation indices and by the lack of effect of oxygen administration. Body cooling of comatose rats at ambient temperature approximately 19 degrees C became slower with succinate, the rate of cooling correlated well with oxygen consumption decrease. Succinate had no potency to modify oxygen consumption and body temperature in intact rats. A condition for antidote effect of the Krebs intermediate was sufficiently high dosage (5 mmol/kg), further dose increase made no odds. Repeated dosing of succinate had more marked protective effect, than a single one, to oxygen consumption and tended to promote the attenuation of lethal effect of barbiturates. These data suggest that suppression of whole body oxygen consumption with barbiturate overdose could be an important contributor to both body cooling and mortality. Intermediates of Krebs cycle, not only succinate, may have a pronounced therapeutic effect under the proper treatment regimen. Availability of Krebs cycle intermediates may be a limiting factor for the whole body oxygen consumption in barbiturate coma, its role in brain needs further elucidation.

  9. Effect of arousal methods for 175 cases of prolonged coma and its factors after severe traumatic brain injury

    Institute of Scientific and Technical Information of China (English)

    江基尧; 包映晖; 殷玉华; 潘耀华; 梁玉敏; 罗其中

    2004-01-01

    Objective: To determine the effect of arousal methods for prolonged coma of 175 patients with severe traumatic brain injury and related factors.Methods: There were 175 cases with persistent coma longer than 1 month after severe traumatic brain injury. Coma lasted 1-12 months. Arousal procedures included hyperbaric oxygen, physical therapy and arousal drugs. Results: In the 175 prolonged coma patients 110 got recovery of consciousness; in 118 cases with coma of 1-3 months, 86 cases recovered consciousness (72.9%); in 42 cases with coma of 4-6 months, 20 cases recovered consciousness (47.6);and in 15 cases with coma of longer than 6 months, only 4 cases recovered consciousness (26.7%). The recovery of consciousness depended on patient's primary brain stem damagme, cerebral hernia, GCS score, and age .Conclusions: Application of appropriate arousal procedures improves recovery of consciousness in patients with prolonged coma.

  10. Molecular modeling-based antioxidant arylidene barbiturates as urease inhibitors.

    Science.gov (United States)

    Khan, Khalid Mohammed; Ali, Muhammad; Wadood, Abdul; Zaheer-ul-Haq; Khan, Momin; Lodhi, Muhammad Arif; Perveen, Shahnaz; Choudhary, Muhammad Iqbal; Voelter, Wolfgang

    2011-09-01

    Previously we have reported arylidene barbiturates 1-18 as a novel class of antioxidants; however, their urease inhibitory potential has not yet been explored. In this communication, molecular docking studies were used to predict the potential ligands from compounds 1-18 which culminated in the identification of certain new urease inhibitors. Ligands were screened in vitro for their urease inhibitory potential. Compound 1, as deduced from modeling studies, was found to be the most active urease inhibitor (13.0 ± 1.2 μM), when compared with the standard thiourea (IC₅₀=21.1 ± 0.3 μM). All of the compounds were found to be nontoxic to Artemia salina in brine shrimp lethality bioassay.

  11. Coma scales: a historical review

    Directory of Open Access Journals (Sweden)

    Ana Luisa Bordini

    2010-12-01

    Full Text Available OBJECTIVE: To describe the most important coma scales developed in the last fifty years. METHOD: A review of the literature between 1969 and 2009 in the Medline and Scielo databases was carried out using the following keywords: coma scales, coma, disorders of consciousness, coma score and levels of coma. RESULTS: Five main scales were found in chronological order: the Jouvet coma scale, the Moscow coma scale, the Glasgow coma scale (GCS, the Bozza-Marrubini scale and the FOUR score (Full Outline of UnResponsiveness, as well as other scales that have had less impact and are rarely used outside their country of origin. DISCUSSION: Of the five main scales, the GCS is by far the most widely used. It is easy to apply and very suitable for cases of traumatic brain injury (TBI. However, it has shortcomings, such as the fact that the speech component in intubated patients cannot be tested. While the Jouvet scale is quite sensitive, particularly for levels of consciousness closer to normal levels, it is difficult to use. The Moscow scale has good predictive value but is little used by the medical community. The FOUR score is easy to apply and provides more neurological details than the Glasgow scale.

  12. Supramolecular assemblies and molecular recognition of amphiphilic schiff bases with barbituric acid in organized molecular films.

    Science.gov (United States)

    Jiao, Tifeng; Liu, Minghua

    2005-02-24

    A bolaform Schiff base, N,N'-bis(salicylidene)-1,10-decanediamine (BSC10), has been synthesized and its interfacial hydrogen bond formation or molecular recognition with barbituric acid was investigated in comparison with that of a single chain Schiff base, 2-hydroxybenzaldehyde-octadecylamine (HBOA). It has been found that while HBOA formed a monolayer at the air/water interface, the bolaform Schiff base formed a multilayer film with ordered layer structure on water surface. When the Schiff bases were spread on the subphase containing barbituric acid, both of the Schiff bases could form hydrogen bonds with barbituric acid in situ in the spreading films. As a result, an increase of the molecular areas in the isotherms was observed. The in situ H-bonded films could be transferred onto solid substrates, and the transferred multilayer films were characterized by various methods such as UV-vis and FT-IR spectrosopies. Spectral changes were observed for the films deposited from the barbituric acid subphase, which supported the hydrogen bond formation between the Schiff bases and barbituric acid. By measuring the MS-TOF of the deposited films dissolved in CHCl3 solution, it was concluded that a 2:1 complex of HBOA with barbituric acid and a 1:2 complex of BSC10 with barbituric acid were formed. On the other hand, when the multilayer films of both Schiff bases were immersed in an aqueous solution of barbituric acid, a similar molecular recognition through the hydrogen bond occurred. A clear conformational change of the alkyl spacer in the bolaform Schiff base was observed during the complex formation with the barbituric acid.

  13. New method for spectrophotometric determination of quinones and barbituric acid through their reaction. A kinetic study

    Science.gov (United States)

    Medien, H. A. A.

    1996-11-01

    A new and sensitive spectrophotometric method is described for the determination of p-benzoquinone, p-chloranil and 1.4-naphthoquinone. The method is based on the reaction between quinones and barbituric acid, by which a color is developed with maximum absorption between 485 and 555 nm in 50% methyl alcohol-water mixture. The absorption of the product obeys Beer's law within the concentration range 0.025-05 mM of orginal quinone. The kinetics of the reaction between p-benzoquinone and barbituric acid was studied in a range of methyl alcohol-water mixtures. The reaction follows overall second order kinetics, first order in each of the reactants. The rate increases with increasing dielectric constant. The method was applied for determination of barbituric acid with p-benzoquinone in the concentration range of 0.025-0.345 mM. Other barbiturates do not interfere.

  14. Comae Berenicids and related activities

    Science.gov (United States)

    Koseki, Masahiro

    2011-12-01

    The Comae Berenicids have been considered as a winter shower but lower meteor activities continue the whole year round in this region. It might be called the meteors of Coma Sororum Medusae (CSM) instead of Comae Berenicids (COM). The CSM radiant passes the zenith twice in lower latitudes of the northern hemisphere and CSM activities vary with the altitude of the radiant. December Leonis Minorids (DLM) and September varepsilon-Perseids (SPE) are distinct from the CSM background meteors, but July Pegasids (JPE), delta-Aurigids (DAU) and nu-Aurigids (NAU) are buried in this complex. The conglomeration of DLM, COM and JCO (January Comae Berenicids) has caused confusion in meteor observations as to whether they are three distinct sources or should be considered as one. A simple model of meteor stream structure shows the clear profile of their activities. Although their radiant drifts are overlapping, they might have different parent objects.

  15. Acute isoniazid intoxication: seizures, acidosis and coma.

    Science.gov (United States)

    Temmerman, W; Dhondt, A; Vandewoude, K

    1999-08-01

    Isoniazid (INH) is the most widely used of the antituberculosis drugs. An acute overdose is potentially fatal and is characterized by the clinical triad of repetitive seizures unresponsive to the usual anticonvulsants, metabolic acidosis with a high anion gap and coma. The diagnosis of INH overdose should be considered in any patient who presents with an unexplained metabolic acidosis and convulsions. The cornerstone of therapy consists in pyridoxine (vitamin B6) and the dose should be equal to the amount of INH ingested. When conservative therapy fails or in case of renal insufficiency, dialysis must be considered. Severe central nervous toxicity can also be caused by chronic ingestion of higher than therapeutic doses of INH. In those cases pyridoxine-therapy can be useful as well. In the present paper a case of acute overdose of INH is reported, followed by a review of the literature.

  16. Prediction of Recovery from Coma After CPR

    Science.gov (United States)

    ... PATIENTS AND THEIR FAMILIES PREDICTION OF RECOVERY FROM COMA AFTER CPR This summary will provide you with ... tests that help doctors predict poor recovery from coma after CPR. In this case, poor recovery means ...

  17. Barbiturate bearing aroylhydrazine derivatives: Synthesis, NMR investigations, single crystal X-ray studies and biological activity

    Science.gov (United States)

    Giziroglu, Emrah; Sarikurkcu, Cengiz; Aygün, Muhittin; Basbulbul, Gamze; Soyleyici, H. Can; Firinci, Erkan; Kirkan, Bulent; Alkis, Ayse; Saylica, Tayfur; Biyik, Halil

    2016-03-01

    A series of barbituric acid aroylhydrazine derivatives have been prepared from their corresponding 1,3-dimethyl-5-acetyl barbituric acid and aroylhydrazines. All compounds have been fully characterized by using FT-IR, multinuclear NMR (1H, 13C) and Mass (MS) spectrometry. We also describe the X-ray crystal structure of 3a, which crystallizes in the monoclinic P21/n space group. The crystal structure is stabilized with infinite linear chains of dimeric units. Furthermore, all compounds were investigated for their tyrosinase inhibition, antioxidative and antimicrobial activies. The results from biological activity assays have shown that all of compounds have excellent antioxidant, significant tyrosinase inhibition and moderate antimicrobial activity.

  18. Effect of Cross-linking Agent on Barbituric Acid-initiated Resin

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    To improve the tensile bond strength of dentin bonding agents, the adhesion between dentin and MMA resin was investigated by applying initiator systems containing 1-cyclohexyl-5-ethyl barbituric acid (CEB), copper acetyl acetonate (CAA), quaternary ammonium chloride (QAC), cupric ion, with the addition of TEGDMA, and pretreatment solution for dentin, and an HEMA primer. The effects of a cross-linking agent on barbituric acid-initiated dentin bonding resin were examined by measuring degree of conversion, molecular weight, hardness of bonding resin, and tensile bond strengths.

  19. Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis.

    Directory of Open Access Journals (Sweden)

    Simon Oakley

    Full Text Available Barbiturates potentiate GABA actions at the GABA(A receptor and act as central nervous system depressants that can induce effects ranging from sedation to general anesthesia. No structural information has been available about how barbiturates are recognized by their protein targets. For this reason, we tested whether these drugs were able to bind specifically to horse spleen apoferritin, a model protein that has previously been shown to bind many anesthetic agents with affinities that are closely correlated with anesthetic potency. Thiopental, pentobarbital, and phenobarbital were all found to bind to apoferritin with affinities ranging from 10-500 µM, approximately matching the concentrations required to produce anesthetic and GABAergic responses. X-ray crystal structures were determined for the complexes of apoferritin with thiopental and pentobarbital at resolutions of 1.9 and 2.0 Å, respectively. These structures reveal that the barbiturates bind to a cavity in the apoferritin shell that also binds haloalkanes, halogenated ethers, and propofol. Unlike these other general anesthetics, however, which rely entirely upon van der Waals interactions and the hydrophobic effect for recognition, the barbiturates are recognized in the apoferritin site using a mixture of both polar and nonpolar interactions. These results suggest that any protein binding site that is able to recognize and respond to the chemically and structurally diverse set of compounds used as general anesthetics is likely to include a versatile mixture of both polar and hydrophobic elements.

  20. Initial Diagnosis and Management of Coma.

    Science.gov (United States)

    Traub, Stephen J; Wijdicks, Eelco F

    2016-11-01

    Coma represents a true medical emergency. Drug intoxications are a leading cause of coma; however, other metabolic disturbances and traumatic brain injury are also common causes. The general emergency department approach begins with stabilization of airway, breathing, and circulation, followed by a thorough physical examination to generate a limited differential diagnosis that is then refined by focused testing. Definitive treatment is ultimately disease-specific. This article presents an overview of the pathophysiology, causes, examination, and treatment of coma.

  1. Neurophysiological assessment of alpha pattern coma.

    OpenAIRE

    1980-01-01

    Somatosensory evoked potentials, blink reflexes, and H wave reflexes, were recorded on several days from three patients with alpha pattern coma. Coma was secondary to cardiac arrest in two cases and to brainstem infarction in one. Results are compatible with damage to the brainstem reticular formation with sparing of thalamo-cortical circuits as the main physiopathological characteristic of alpha pattern coma. This condition should not be regarded as a discrete entity when establishing the pr...

  2. Coma associated with microscopy-diagnosed Plasmodium vivax: a prospective study in Papua, Indonesia.

    Directory of Open Access Journals (Sweden)

    Daniel A Lampah

    2011-06-01

    Full Text Available BACKGROUND: Coma complicates Plasmodium falciparum infection but is uncommonly associated with P. vivax. Most series of vivax coma have been retrospective and have not utilized molecular methods to exclude mixed infections with P. falciparum. METHODS: We prospectively enrolled patients hospitalized in Timika, Indonesia, with a Glasgow Coma Score (GCS ≤10 and P. vivax monoinfection on initial microscopy over a four year period. Hematological, biochemical, serological, radiological and cerebrospinal fluid (CSF examinations were performed to identify other causes of coma. Repeat microscopy, antigen detection and polymerase chain reaction (PCR were performed to exclude infections with other Plasmodium species. RESULTS: Of 24 patients fulfilling enrolment criteria, 5 had clear evidence for other non-malarial etiologies. PCR demonstrated 10 mixed infections and 3 P. falciparum monoinfections. 6 (25% patients had vivax monoinfection and no apparent alternative cause, with a median GCS of 9 (range 8-10 and a median coma duration of 42 (range 36-48 hours. CSF leukocyte counts were <10/ul (n=3; 2 of the 3 patients without CSF examination recovered with antimalarial therapy alone. One patient had a tremor on discharge consistent with a post-malarial neurological syndrome. No patient had other organ dysfunction. The only death was associated with pure P. falciparum infection by PCR. Vivax monoinfection-associated risk of coma was estimated at 1 in 29,486 clinical vivax infections with no deaths. In comparison, the risk of falciparum-associated coma was estimated at 1 in 1,276 clinical infections with an 18.5% mortality rate. CONCLUSIONS: P. vivax-associated coma is rare, occurring 23 times less frequently than that seen with falciparum malaria, and is associated with a high proportion of non-malarial causes and mixed infections using PCR. The pathogenesis of coma associated with vivax malaria, particularly the role of comorbidities, is uncertain and

  3. Supramolecular chiral host-guest nanoarchitecture induced by the selective assembly of barbituric acid derivative enantiomers

    Science.gov (United States)

    Sun, Xiaonan; Silly, Fabien; Maurel, Francois; Dong, Changzhi

    2016-10-01

    Barbituric acid derivatives are prochiral molecules, i.e. they are chiral upon adsorption on surfaces. Scanning tunneling microscopy reveals that barbituric acid derivatives self-assemble into a chiral guest-host supramolecular architecture at the solid-liquid interface on graphite. The host nanoarchitecture has a sophisticated wavy shape pattern and paired guest molecules are nested insides the cavities of the host structure. Each unit cell of the host structure is composed of both enantiomers with a ratio of 1:1. Furthermore, the wavy patterns of the nanoarchitecture are formed from alternative appearance of left- and right-handed chiral building blocks, which makes the network heterochiral. The functional guest-host nanoarchitecture is the result of two-dimensional chiral amplification from single enantiomers to organizational heterochiral supramolecular self-assembly.

  4. Synthesis and mechanism of formation of oxadeazaflavines by microwave thermal cyclization of ortho-halobenzylidene barbiturates

    Energy Technology Data Exchange (ETDEWEB)

    Figueroa-Villar, J. Daniel; Oliveira, Sandra C.G. de, E-mail: figueroa@ime.eb.br [Grupo de Quimica Medicinal, Departamento de Quimica, Instituto Militar de Engenharia, Rio de Janeiro, RJ (Brazil)

    2011-09-15

    The thermal cyclization reaction of o-halobenzylidene barbiturates was developed as an efficient and simple method for the preparation of oxadeazaflavines. The use of solid state reaction conditions with microwave irradiation afforded the products in 5 min with 47 to 98% yield. Experimental synthetic results and thermogravimetric reaction analyses agree with the molecular modeling mechanism simulation, indicating that this reaction occurs through an intramolecular hetero-Diels-Alder cyclization followed by fast re-aromatization. (author)

  5. Postanoxic coma: prognosis after therapeutic hypothermia

    NARCIS (Netherlands)

    Bouwes, A.

    2012-01-01

    Postanoxic coma, also known as anoxic-ischemic coma, is a state of unconsciousness caused by global anoxia of the brain. The most common cause is primary cardiac arrest followed by successful cardiopulmonary resuscitation (CPR). Other causes include primary respiratory arrest, near-drowning, strangu

  6. Featured Image: A Comet's Coma

    Science.gov (United States)

    Kohler, Susanna

    2016-11-01

    This series of images (click for the full view!) features the nucleus of comet 67P/Churymov-Gerasimenko. The images were taken with the Wide Angle Camera of RosettasOSIRIS instrument asRosetta orbited comet 67P. Each column represents a different narrow-band filter that allows us to examine the emission of a specific fragment species, and the images progress in time from January 2015 (top) to June 2015 (bottom). In a recent study, Dennis Bodewits (University of Maryland) and collaborators used these images to analyze the comets inner coma, the cloud of gas and dust produced around the nucleus as ices sublime. OSIRISs images allowed the team to explore how the 67Ps inner coma changed over time as the comet approached the Sun marking the first time weve been able to study such an environment at this level of detail. To read more about what Bodewits and collaborators learned, you can check out their paper below!CitationD. Bodewits et al 2016 AJ 152 130. doi:10.3847/0004-6256/152/5/130

  7. Allyl m-Trifluoromethyldiazirine Mephobarbital: An Unusually Potent Enantioselective and Photoreactive Barbiturate General Anesthetic

    Energy Technology Data Exchange (ETDEWEB)

    Savechenkov, Pavel Y.; Zhang, Xi; Chiara, David C.; Stewart, Deirdre S.; Ge, Rile; Zhou, Xiaojuan; Raines, Douglas E.; Cohen, Jonathan B.; Forman, Stuart A.; Miller, Keith W.; Bruzik, Karol S. (Harvard-Med); (Mass. Gen. Hosp.); (UIC)

    2012-12-10

    We synthesized 5-allyl-1-methyl-5-(m-trifluoromethyl-diazirynylphenyl)barbituric acid (14), a trifluoromethyldiazirine-containing derivative of general anesthetic mephobarbital, separated the racemic mixture into enantiomers by chiral chromatography, and determined the configuration of the (+)-enantiomer as S by X-ray crystallography. Additionally, we obtained the {sup 3}H-labeled ligand with high specific radioactivity. R-(-)-14 is an order of magnitude more potent than the most potent clinically used barbiturate, thiopental, and its general anesthetic EC{sub 50} approaches those for propofol and etomidate, whereas S-(+)-14 is 10-fold less potent. Furthermore, at concentrations close to its anesthetic potency, R-(-)-14 both potentiated GABA-induced currents and increased the affinity for the agonist muscimol in human {alpha}1{beta}2/3{gamma}2L GABA{sub A} receptors. Finally, R-(-)-14 was found to be an exceptionally efficient photolabeling reagent, incorporating into both {alpha}1 and {beta}3 subunits of human {alpha}1{beta}3 GABAA receptors. These results indicate R-(-)-14 is a functional general anesthetic that is well-suited for identifying barbiturate binding sites on Cys-loop receptors.

  8. Coma blisters with hypoxemic respiratory failure.

    Science.gov (United States)

    Agarwal, Abhishek; Bansal, Meghana; Conner, Kelly

    2012-03-15

    A 24-year-old woman with quadriplegia was admitted with respiratory failure because of pneumonia. She was on multiple medications including diazepam, oxycodone, and amitriptyline, known to be associated with coma blisters, though she did not overdose on any of them. On hospital day 2, she developed multiple blisters on both sides of her right forearm and hand. Skin biopsy showed eccrine gland degeneration consistent with coma blisters. It was felt that hypoxemia from her pneumonia contributed to the development of these blisters, which occurred on both pressure and non-pressure bearing areas of the arm. Coma blisters are self-limited skin lesions that occur at sites of maximal pressure, mostly in the setting of drug overdose. However, coma blisters may occur with metabolic and neurological conditions resulting in coma.

  9. 语言呼唤联合音乐促醒方案对重型创伤性脑损伤昏迷病人清醒时间及治疗效果的影响%Influence of language calls combined with music therapy on sober time and therapeutic effect of coma patients with severe traumatic brain inj ury

    Institute of Scientific and Technical Information of China (English)

    顾彩萍; 强荧艳; 李佳清; 廖照娣; 张晓路; 陈维艳

    2016-01-01

    Objective:To explore the influence of language calls combined with music therapy on sober time and therapeutic effect of coma patients with severe traumatic brain inj ury.Methods:According to the random num-ber table method,a total of 86 coma patients with severe traumatic brain injury treated in department of Neuro-surgery from January 2012 to December 2015 were divided to intervention group and control group,43 cases in each.The patients in control group received the routine nursing,in addition,the patients in intervention group added language calls combined with music therapy.Both groups of patients were investigated at the time of ad-mission,day 4th,8th,12th,16th and 20th after intervention with Glasgow coma Scale(GCS);the duration was recorded from coma until the awake state;record the number of conscious patients was recorded during the in-tervention.Results:The GCS score of intervention group on the 20th day after intervention was statistically sig-nificant higher than that control group(P0.05),干预后第20天研究组 GCS评分高于对照组,差异有统计学意义(P<0.05);研究组病人在治疗期间清醒率为79.1%,高于对照组的41.9%,差异有统计学意义(P<0.05);研究组病人清醒时间为(18.4±4.2)d,早于对照组的(26.3±5.9)d,差异有统计学意义(P<0.05)。[结论]以语言呼唤联合音乐促醒方案有助于促进重型创伤性脑损伤昏迷病人的意识觉醒,利于病人病情转归。

  10. The effect observation of early hyperbaric oxygen combined music therapy on brain trauma coma wake and prognosis%早期高压氧联合音乐疗法对脑外伤昏迷促醒及预后的效果

    Institute of Scientific and Technical Information of China (English)

    黄的; 徐斌

    2016-01-01

    目的:观察早期高压氧联合音乐疗法对脑外伤昏迷促醒率及预后程度。方法:将170例脑外伤昏迷的患者,随机分为对照组和观察组,各85例。对照组给予常规药物治疗及康复护理,观察组在此基础上给予高压氧及音乐疗法,随访6个月,比较两组患者清醒时间及格拉斯哥预后结局量表(Glasgow outcome scale,GOS)等级情况。结果:两组患者的清醒时间及格拉斯哥预后结局等级比较,差异有统计学意义( P <0.05)。结论:早期高压氧联合音乐疗法对脑外伤昏迷促醒有较好的临床疗效,而且能减轻后遗症。%Objective:To observe the effect of early hyperbaric oxygen combined music therapy on brain trauma coma wake and prognosis. Nethods:170 cases of brain injury coma were randomly divided into control group(85 cases)and observation group(85cases). The control group was given conventional drugs and rehabilitation nursing,and the observation group with music therapy and hyperbaric oxygen treatment. After active treatment and follow - up for six months,the awake time,and Glasgow Outcome Scale for prognostic outcomes in the two groups were compared. Results:The comparison of awake time,and Glasgow Outcome Scale for prognostic outcomes between the two groups difference was statistically sig-nificant( P < 0. 05). Conclusion:Early hyperbaric oxygen combined music therapy on brain injury coma wake has better clinical curative effect, and can reduce sequel.

  11. Models for Cometary Comae Containing Negative Ions

    Science.gov (United States)

    Cordiner, M. A.; Charnley, S. B.

    2012-01-01

    The presence of negative ions (anions) in cometary comae is known from Giotto mass spectrometry of IP/Halley. The anions O(-), OH(-), C(-), CH(-) and CN(-) have been detected, as well as unidentified anions with masses 22-65 and 85-110 amu [I]. Organic molecular anions such as C4H(-) and C6H(-) are known to have a significant impact on the charge balance of interstellar clouds and circumstellar envelopes and have been shown to act as catalysts for the gas phase synthesis of larger hydrocarbon molecules in the ISM, but their importance in cometary comae has not yet been fully explored. We present details of our new models for the chemistry of cometary comae that include atomic and molecular anions. We calculate the impact of these anions on the charge balance and examine their importance for cometary coma chemistry.

  12. Multi-Component synthesis and computational studies of three novel thio-barbituric acid carbohydrate derivatives

    Science.gov (United States)

    Gupta, Stuti; Khare, Naveen K.

    2017-01-01

    The thio-barbituric acid is convenient starting compound for the preparation of fused heterocycles and its 5-substituted derivatives which are pharmacologically one of the most important classes of compounds. The fused compounds of thio-barbituric acid, 4-(1R,2S,3S,4S)-1,2,3,4,5-tetrahydroxy pentyl-10-phenyl-1,3,6,8,9,10 hexahydro-2,7-dithiooxopyrido [2,3-d; 6,5'] dipyrimidine-4,5 diones (1), 4-(1S,2S,3S,4S)-1,2,3,4,5-tetrahydroxy pentyl-10-phenyl-1,3,6,8,9,10 hexahydro-2,7-dithiooxopyrido [2,3-d; 6,5'] dipyrimidine-4,5 diones (2), 3-(1R,2S,3S)-1,2,3,4-tetrahydroxy butyl-10-phenyl-1,3,6,8,9,10 hexahydro-2,7-dithiooxopyrido [2,3-d; 6,5'] dipyrimidine-4,5 diones (3) have been synthesized in single step by the condensation of thio-barbituric acid with sugars (L-rhamnose, L-fucose and L-arabinose) & aniline using para-toluene sulfonic acid (p-TSA) as an effective acid catalyst under refluxing conditions. The molecular structure and detailed spectroscopic analysis of all three novel synthesized thiones derivatives have been performed using experimental techniques like 1H, 13C NMR, 2D (COSY, HSQC, DEPT-135 and DEPT-90) as well as theoretical calculations by density functional theory (DFT) using B3LYP and 6-311G + (d, p) basis set. The strength and nature of weak intramolecular interactions have been studied by atom in molecule (AIM) approach. Global reactivity descriptors have been computed to predict reactivity and reactive sites in the molecule.

  13. Evaluation of coma patients after cardiopulmonary resuscitation

    Institute of Scientific and Technical Information of China (English)

    SU Ying-ying; YANG Qing-lin; PANG Ying; LV Xiang-ping

    2005-01-01

    Background Coma after cardiopulmonary resuscitation (CPR) is commonly seen in daily clinical practice. How to objectively evaluate brain function after CPR is essential to the following treatment. Coma patients after CPR had been studied prospectively at the Neuro-Intensive Care Unit of Xuanwu Hospital since 2002. In this study, we focused on the topic of how to evaluate the severity of coma after CPR .Methods From April 2002 to November 2004, patients in coma 24 hours after CPR were monitored, the evaluation methods included Glasgow coma score (GCS),brain stem reflection, and spinal reflection. Laboratory evaluation included electroencephalography (EEG),brainstem auditory evoked potential (BAEP), short latency somatosensory evoked potential (SLSEP), and transcranial Doppler (TCD) .Results Twenty-four of 35 patients(68.57%)were in deep coma. The GCS was 3 except for 2 patients;EEG was evaluated not less than grade Ⅳ except for 4 patients, BAEP was evaluated as grade Ⅲ except for 3 patients, and SLSEP was evaluated as grade Ⅲ except for 1 patient.Twenty-four patients died within 1 month and 11 of them(45.83%)were determined as brain death. Glasgow outcome score (GOS) was evaluated as grade Ⅰ. Eleven of the 35 patients survived and their consciousness changed from deep coma to coma vigil. EEG was evaluated as gradeⅠin 5 patients, BAEP and SLSEP were evaluated as grade Ⅰ in 3 patients, and GOS was all evaluated as grade Ⅱ among the 11 patients.Two patients(18.18%)regained consciousness in 35 and 90 days after cardiopulmonary resuscitation and GOS was evaluated as grade Ⅳ and Ⅲ, respectively.Conclusion Combined or continuous evaluation of clinical examinations and laboratory tests can accurately and objectively determine brain function after CPR.

  14. Postanoxic coma: prognosis after therapeutic hypothermia

    OpenAIRE

    2012-01-01

    Postanoxic coma, also known as anoxic-ischemic coma, is a state of unconsciousness caused by global anoxia of the brain. The most common cause is primary cardiac arrest followed by successful cardiopulmonary resuscitation (CPR). Other causes include primary respiratory arrest, near-drowning, strangulation, and prolonged severe hypotension. Patients may recover consciousness after variable periods of time, or remain unconscious indefinitely. The main focus of this thesis is on prediction of ou...

  15. A Greener, Efficient Approach to Michael Addition of Barbituric Acid to Nitroalkene in Aqueous Diethylamine Medium

    Directory of Open Access Journals (Sweden)

    Hany J. Al-Najjar

    2014-01-01

    Full Text Available An efficient method for the synthesis of a variety of pyrimidine derivatives 3a–t by reaction of barbituric acids 1a,b as Michael donor with nitroalkenes 2a–k as Michael acceptor using an aqueous medium and diethylamine is described. This 1,4-addition strategy offers several advantages, such as using an economic and environmentally benign reaction media, high yields, versatility, and shorter reaction times. The synthesized compounds were identified by 1H-NMR, 13C-NMR, CHN, IR, and MS. The structure of compound 3a was further confirmed by single crystal X-ray structure determination.

  16. A Hot Spot in Coma

    CERN Document Server

    Donnelly, R H; Forman, W R; Jones, C; Churazov, E; Gilfanov, M R

    1999-01-01

    We study the temperature structure of the central part (r<18' ~0.7 h50**-1 Mpc) of the Coma cluster of galaxies using ASCA data. Two different analysis methods produce results in good agreement with each other and reveal the presence of interesting structures in the gas temperature distribution. Globally, the average temperature in the center of the cluster is 9.0 +/- 0.6 keV in good agreement with previous results. Superimposed on this, we find a cool area with temperatures of 4-6 keV associated with a filament of X-ray emission extending southeast from the cluster center detected by Vikhlinin and coworkers. We also find a hot spot with a temperature of around 13 keV displaced north from the central peak of emission. The distribution of the gas temperatures and relative specific entropies suggests that the cool features are most likely gas stripped from a galaxy group centered on NGC 4874 falling toward the core from outside, while the hot spot located ``ahead'' of this in-falling gas is due to shock heat...

  17. Low risk of development of substance dependence for barbiturates and clobazam prescribed as antiepileptic drugs: results from a questionnaire study.

    Science.gov (United States)

    Uhlmann, Carmen; Fröscher, Walter

    2009-01-01

    There is no systematical research about the topic of dependence on antiepileptic drugs (AED) for patients with epilepsy, despite the fact that barbiturates and benzodiazepines comprise a potential risk of dependence. We hypothesize that there is no psychological substance dependence for patients with epilepsy, possibly because of their outcome expectations. The aim of the study was to examine these patients in terms of substance dependence. One hundred inpatients at the Lake Constance Epilepsy Center were asked about their experiences with AED in terms of dependence in a structured interview. We registered general statements about dependence of AED, markers for substance dependence, and outcome expectations. About 50% of the patients reported withdrawal symptoms and the development of tolerance, but less than 10% noticed loss of control and craving. Withdrawal symptoms and development of tolerance were significantly lower in a group of patients without barbiturates or clobazam versus patients with barbiturates or/and clobazam. There was no significant difference between these two groups in psychological criteria of dependence, that is, loss of control and craving. Outcome expectations of AED were clearly related to the efficacy against seizures, and only to a small amount to psychotropic effects. The study demonstrates that physiological variables of dependence are present more in patients with epilepsy with a permanent intake of barbiturates or clobazam, but psychological variables of dependence are rarely present in epileptic patients, with or without an intake of barbiturates and clobazam. These results confirm our hypothesis that substance dependence is not a major problem in benzodiazepines and barbiturates in patients with epilepsy. Outcome expectations seem to be related mainly to the anticonvulsant and not the psychotropic effect. This might be the reason for the absence of dependence.

  18. Nuclear magnetic resonance and molecular modeling study of exocyclic carbon-carbon double bond polarization in benzylidene barbiturates

    Science.gov (United States)

    Figueroa-Villar, J. Daniel; Vieira, Andreia A.

    2013-02-01

    Benzylidene barbiturates are important materials for the synthesis of heterocyclic compounds with potential for the development of new drugs. The reactivity of benzylidene barbiturates is mainly controlled by their exocyclic carbon-carbon double bond. In this work, the exocyclic double bond polarization was estimated experimentally by NMR and correlated with the Hammett σ values of the aromatic ring substituents and the molecular modeling calculated atomic charge difference. It is demonstrated that carbon chemical shift differences and NBO charge differences can be used to predict their reactivity.

  19. Synthesis, characterization, thermal behaviour and single crystal X-ray analysis of two new insensitive high energy density materials [8-hydroxyquinolinium 5-(2,4,6-trinitrophenyl)barbiturate (I) and 8-hydroxyquinolinium 5-(5-chloro-2,4-dinitrophenyl)-1,3-dimethyl barbiturate (II)

    Science.gov (United States)

    Manickkam, V.; Devi, P. Poornima; Kalaivani, D.

    2014-12-01

    Barbiturates I and II have been synthesized as maroon red and red orange coloured solids by mixing the ethanolic solutions of 2-chloro-1,3,5-trinitrobenzene ( TNCB), pyrimidine-2,4,6(1 H,3 H,5 H)-trione [barbituric acid ( BA)] and 8-hydroxyquinoline and 1,3-dichloro-4,6-dinitrobenzene ( DCDNB), 1,3-dimethylpyrimidine-2,4,6(1 H,3 H,5 H)-trione(1,3-dimethylbarbituric acid) and 8-hydroxyquinoline respectively. The structures of these two barbiturates have been predicted from the spectral studies (UV-VIS, IR, 1H NMR, 13C NMR, mass) and elemental analysis. Qualitative tests have been carried out to infer the presence of nitrogen and nitro groups and also chlorine atom in barbiturate II. Slow evaporation of ethanol-dimethylsulphoxide/ethanol solutions of barbiturate I/barbiturate II at 293 K yielded good for X-Ray diffraction crystals. Single crystal X-ray diffraction studies of the crystals further confirm the putative structures of the barbiturates. The asymmetric unit of the barbiturate I comprises of 8-hydroxyquinolinium cation, 5-(2,4,6-trinitrophenyl) barbiturate anion and a molecule of dimethylsulphoxide (DMSO), which is used as a recrystallizing solvent. It crystallizes in the triclinic system with space group (centrosymmetric). Barbiturate II crystallizes in the orthorhombic system with space group P212121 (non-centrosymmetric). Barbiturates I and II are stable towards an impact sensitivity test, when a weight of 2 kg mass hammer is dropped from a height of 160 cm of the instrument. TGA/ DTA analyses at four different heating rates (5, 10, 20, and 40 K/min) imply that they undergo exothermic decomposition (˜85%) in three different stages between 273 and 873 K. Activation energies for these decomposition processes have been calculated by employing Kissinger and Ozawa plots. Impact sensitivity test and activation energies have revealed that the titled barbiturates are insensitive high energy density materials ( IHEDMS).

  20. Acupuncture Treatment for 15 Cases of Post-traumatic Coma

    Institute of Scientific and Technical Information of China (English)

    He Jing; Wu Bin; Zhang Yongling; Wang Xinzhong

    2005-01-01

    In order to observe the effects of acupuncture combined with point-injection therapy on post-traumatic coma, 30 such cases were randomly divided into the following two groups. The patients in the control group were simply treated with the basic neural medical treatment; while patients in the treatment group were treated by acupuncture and point-injection therapy in addition to the above treatment. Comparisons were made between the two groups in the therapeutic effects by GCS evaluations as well as in the changes of main symptoms. The results showed that the GCS value in the treatment group was higher than that of the control group, but with no statistical significance (P>0.05). However, the main symptoms of the patients in treatment group, such as aphasia, hemiplegia, and injuries of cranial nerves (including injuries of the facial, oculomotor and abducent nerves) were obviously improved, showing significant differences as compared with the control group (P<0.05). Conclusion can be made that acupuncture combined with point-injection has the consciousness-inducing effect for post-traumatic coma, and shows good effects for the cranial nerve injuries and aphasia.

  1. Diagnosis of reversible causes of coma.

    Science.gov (United States)

    Edlow, Jonathan A; Rabinstein, Alejandro; Traub, Stephen J; Wijdicks, Eelco F M

    2014-12-06

    Because coma has many causes, physicians must develop a structured, algorithmic approach to diagnose and treat reversible causes rapidly. The three main mechanisms of coma are structural brain lesions, diffuse neuronal dysfunction, and, rarely, psychiatric causes. The first priority is to stabilise the patient by treatment of life-threatening conditions, then to use the history, physical examination, and laboratory findings to identify structural causes and diagnose treatable disorders. Some patients have a clear diagnosis. In those who do not, the first decision is whether brain imaging is needed. Imaging should be done in post-traumatic coma or when structural brain lesions are probable or possible causes. Patients who do not undergo imaging should be reassessed regularly. If CT is non-diagnostic, a checklist should be used use to indicate whether advanced imaging is needed or evidence is present of a treatable poisoning or infection, seizures including non-convulsive status epilepticus, endocrinopathy, or thiamine deficiency.

  2. Barbiturate ingestion in three adult captive tigers (Panthera tigris and concomitant fatal botulism of one : clinical communication

    Directory of Open Access Journals (Sweden)

    J. H. Williams

    2011-05-01

    Full Text Available Zoo animals, including tigers, have been reported to suffer from barbiturate intoxication, with pentabarbitone being most commonly recorded. Clinical signs range from mild ataxia to general anaesthesia with recovery over hours to days with several factors affecting hepatic barbiturate metabolism and tissue partitioning. Botulism is an often fatal intoxication in man, animals, birds and certain fish. The occurrence in carnivores is uncommon to rare, with only 2 reports found of botulism in felids. This report relates to 3 adult captive cohabiting tigers that simultaneously developed signs of abdominal discomfort, progressive ataxia, recumbency and comatose sleep resembling stage 2 anaesthesia, alternating with periods of distracted wakefulness and ataxic movements. These signs occurred 4 days after being fed the carcass of a horse that had ostensibly died of colic and not been euthanased. The male tiger that was the dominant animal in the feeding hierarchy was worst affected and had to be given intravenous fluids. The female that was lowest in hierarchy was unaffected. After 48-72 hours of treatment at the Onderstepoort Veterinary Academic Hospital the females could eat and made an uneventful recovery. The male tiger showed partial recovery but died during the night a few hours after drinking water on his return to the owner. Necropsy revealed severe oesophageal dilation and impaction with decaying grass; some of this material and water were present in the pharynx and trachea, and had been aspirated causing acute widespread bronchopneumonia. Colon content tested negative for common pesticides but, together with liver, tested positive for barbiturate. Serum taken on the day of admission had tested negative for barbiturate and the residual serum from the 3 animals later tested negative for botulinum toxin. Colon and oesophageal content from the male at necropsy were positive for Clostridium botulinum toxin type C by the mouse bioassay

  3. [Coma, dream and thinking: a semiotic approach].

    Science.gov (United States)

    Balat, M

    1990-01-01

    The notion of "frontier-dream", with a high perceptive direct content, is defined from accounts of dream experienced during coma. Then, from discussions with nursing-team working in units for comatose patients in a wakeful state, a protocol is proposed based on semiotic and psychoanalytical factors which aims at ensuring the global care of the comatose patient considered as a person.

  4. New red jewels in Coma Berenices

    Energy Technology Data Exchange (ETDEWEB)

    Terrien, Ryan C.; Mahadevan, Suvrath; Deshpande, Rohit; Bender, Chad F.; Hearty, Frederick R.; Schneider, Donald P. [Department of Astronomy and Astrophysics, The Pennsylvania State University, 525 Davey Laboratory, University Park, PA 16802 (United States); Cargile, Phillip A.; Pepper, Joshua; Rodriguez, Joseph E.; Siverd, Robert J.; Stassun, Keivan G. [Department of Physics and Astronomy, Vanderbilt University, VU Station 1807, Nashville, TN 37235 (United States); Cottaar, Michiel [Institute for Astronomy, ETH Zürich, Wolfgang-Pauli-Strasse 27, CH-8093 Zurich (Switzerland); Allende Prieto, Carlos [Instituto de Astrofísica de Canarias (IAC), C/Vía Láctea, s/n, E-38200 La Laguna, Tenerife (Spain); Fleming, Scott W. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21211 (United States); Frinchaboy, Peter M.; Jackson, Kelly M. [Department of Physics and Astronomy, Texas Christian University, TCU Box 298840, Fort Worth, TX 76129 (United States); Johnson, Jennifer A. [Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Majewski, Steven R.; Nidever, David L. [Department of Astronomy, University of Virginia, P.O. Box 400325, Charlottesville, VA 22904-4325 (United States); Weaver, Benjamin A., E-mail: rct151@psu.edu [Center for Cosmology and Particle Physics, New York University, New York, NY 10003 (United States); and others

    2014-02-20

    We have used Sloan Digital Sky Survey-III (SDSS-III) Apache Point Observatory Galactic Evolution Experiment (APOGEE) radial velocity observations in the near-infrared H-band to explore the membership of the nearby (86.7 ± 0.9 pc) open cluster Coma Berenices (Melotte 111), concentrating on the poorly populated low-mass end of the main sequence. Using SDSS-III APOGEE radial velocity measurements, we confirm the membership of eight K/M dwarf members, providing the first confirmed low-mass members of the Coma Berenices cluster. Using R ∼ 2000 spectra from IRTF-SpeX, we confirm the independently luminosity classes of these targets, and find their metallicities to be consistent with the known solar mean metallicity of Coma Berenices and of M dwarfs in the solar neighborhood. In addition, the APOGEE spectra have enabled measurement of vsin i for each target and detection for the first time of the low-mass secondary components of the known binary systems Melotte 111 102 and Melotte 111 120, as well as identification of the previously unknown binary system 2MASS J12214070+2707510. Finally, we use Kilodegree Extremely Little Telescope photometry to measure photometric variability and rotation periods for a subset of the Coma Berenices members.

  5. Therapeutic options to enhance coma arousal after traumatic brain injury: state of the art of current treatments to improve coma recovery.

    Science.gov (United States)

    Cossu, Giulia

    2014-04-01

    Traumatic brain injury is a leading cause of death and disability. Optimizing the recovery from coma is a priority in seeking to improve patients' functional outcomes. Standards of care have not been established: pharmacological interventions, right median nerve and sensory stimulation, dorsal column stimulation (DCS), deep brain stimulation, transcranial magnetic stimulation, hyperbaric oxygen therapy and cell transplantation have all been utilized with contrasting results. The aim of this review is to clarify the indications for the various techniques and to guide the clinical practice towards an earlier coma arousal. A systematic bibliographic search was undertaken using the principal search engines (Pubmed, Embase, Ovid and Cochrane databases) to locate the most pertinent studies. Traumatic injury is a highly individualized process, and subsequent impairments are dependent on multiple factors: this heterogeneity influences and determines therapeutic responses to the various interventions.

  6. Nucleobase-Based Barbiturates: Their Protective Effect against DNA Damage Induced by Bleomycin-Iron, Antioxidant, and Lymphocyte Transformation Assay

    Directory of Open Access Journals (Sweden)

    Bhaveshkumar D. Dhorajiya

    2014-01-01

    Full Text Available A number of nucleobase-based barbiturates have been synthesized by combination of nucleic acid bases and heterocyclic amines and barbituric acid derivatives through green and efficient multicomponent route and one pot reaction. This approach was accomplished efficiently using aqueous medium to give the corresponding products in high yield. The newly synthesized compounds were characterized by spectral analysis (FT-IR, 1H NMR, 13C NMR, HMBC, and UV spectroscopy and elemental analysis. Representative of all synthesized compounds was tested and evaluated for antioxidant, bleomycin-dependent DNA damage, and Lymphocyte Transformation studies. Compounds TBC > TBA > TBG showed highest lymphocyte transformation assay, TBC > TBA > BG showed inhibitory antioxidant activity using ABTS methods, and TBC > BPA > BAMT > TBA > 1, 3-TBA manifested the best protective effect against DNA damage induced by bleomycin.

  7. Piracetam and TRH analogues antagonise inhibition by barbiturates, diazepam, melatonin and galanin of human erythrocyte D-glucose transport

    OpenAIRE

    2004-01-01

    Nootropic drugs increase glucose uptake into anaesthetised brain and into Alzheimer's diseased brain. Thyrotropin-releasing hormone, TRH, which has a chemical structure similar to nootropics increases cerebellar uptake of glucose in murine rolling ataxia. This paper shows that nootropic drugs like piracetam (2-oxo 1 pyrrolidine acetamide) and levetiracetam and neuropeptides like TRH antagonise the inhibition of glucose transport by barbiturates, diazepam, melatonin and endogenous neuropeptide...

  8. Behaviour of Some Activated Nitriles Toward Barbituric Acid, Thiobarbituric Acid and 3-Methyl-1-Phenylpyrazol-5-one

    Directory of Open Access Journals (Sweden)

    M. M. Habashy

    2000-05-01

    Full Text Available The effect of some active methylene containing heterocyclic compounds, namely barbituric acid, thiobarbituric acid and 3-methyl-1-phenylpyrazol-5-one on a-cyano-3,4,5-trimethoxycinnamonitrile and ethyl a-cyano-3,4,5-trimethoxycinnamate (1a,b was investigated. The structure of the new products was substantiated by their IR,1H-NMR and mass spectra.

  9. Theoretical Studies on Electronic Spectra and Second-order Nonlinear Optical Properties of Barbituric Acid Derivatives Substituted with Schiff Base

    Institute of Scientific and Technical Information of China (English)

    SUN,Gang(孙刚); QIU,Yong-Qing(仇永清); SUN,Hai-Zhu(孙海珠); SU,Zhong-Min(苏忠民); FENG,Jing-Dong(冯静东); ZHU,Yu-Lan(朱玉兰)

    2004-01-01

    The structures of barbituric acid derivatives substituted with Schiff base were optimized using ab initio HF method at 6-31G basis set.Based on the optimized structures,the electronic spectra were obtained by INDO/CI method.The second-order nonlinear optical (NLO) coefficients βu were calculated according to the sum-over-states (SOS) formula.In addition,the effect of conjugation on electronic spectra and second-order NLO coefficients was investigated.The influence of exchange between C and N atoms as well as the substituted effect on the barbituric acid was discussed.It was indicated that the exchange between C and N atoms on Schiff base is important for enhancing the NLO coefficient of the whole molecule with donor and acceptor (D-A).Meanwhile significant changes in electron donation and acception were observed as substituents changes positions.Among the designed models,molecule 1b has maximal βμ value of 124.65 × 10-30 esu.About molecule 1b,barbituric acid is considered as an accepted electronic group and the position of N atom on Schiff base is close to it.

  10. Chemical microenvironment mediated formation of organicnanostructures from self-assembly of melamine and barbituric acid derivatives

    Institute of Scientific and Technical Information of China (English)

    ZHUANG; Jiaqi; (庄家骐); WANG; Gang; (王刚); Lü; Nan; (吕男); YANG; Wensheng; (杨文胜); JIANG; Yueshun; (姜月顺); LI; Tiejin; (李铁津)

    2002-01-01

    The recent progresses on constructing organic nanostructures from the self-assembly of melamine and barbituric acid derivatives are reviewed. By mediating the chemical microenvironment during the self-assembly, the information contained in the molecular components can be expressed at different levels, thus resulting in the formation of different organic nanostructures. When the assembly is carried out in anhydrous chloroform, a kind of asymmetric layered structure with a d value of 4.1 nm is obtained. When a little amount of polar solvent such as alcohol is contained in the chloroform, organic nanotubes with diameter of 6 nm and length of several hundreds of nanometers are observed. After being treated by appropriate polar solvents, the nanotubes are induced into supercoils with diameter of about 300 nm and length of several tens of microns. The sensitivity of the self-assembly process origins from the weak noncovalent intermolecular interactions between the molecular components. The enthalpy change of such interactions is pretty small, so slight change of the molecular structure or microenvironment could affect the primary equilibrium, resulting in the rearrangement and transformation of the supramolecular structure.

  11. Myxedema Coma: A New Look into an Old Crisis

    Directory of Open Access Journals (Sweden)

    Vivek Mathew

    2011-01-01

    Full Text Available Myxedema crisis is a severe life threatening form of decompensated hypothyroidism which is associated with a high mortality rate. Infections and discontinuation of thyroid supplements are the major precipitating factors while hypothermia may not play a major role in tropical countries. Low intracellular T3 leads to cardiogenic shock, respiratory depression, hypothermia and coma. Patients are identified on the basis of a low index of suspicion with a careful history and examination focused on features of hypothyroidism and precipitating factors. Arrythmias and coagulation disorders are increasingly being identified in myxedema crisis. Thyroid replacement should be initiated as early as possible with careful attention to hypotension, fluid replacement and steroid replacement in an intensive care facility. Studies have shown that replacement of thyroid hormone through ryles tube with a loading dose and maintenance therapy is as efficacious as intravenous therapy. In many countries T3 is not available and oral therapy with T4 can be used effectively without major significant difference in outcomes. Hypotension, bradycardia at presentation, need for mechanical ventilation, hypothermia unresponsive to treatment, sepsis, intake of sedative drugs, lower GCS and high APACHE II scores and Sequential Organ Failure Assessment (SOFA scores more than 6 are significant predictors of mortality in myxedema crisis. Early intervention in hypothyroid patients developing sepsis and other precipitating factors and ensuring continued intake of thyroid supplements may prevent mortality and morbidity associated with myxedema crisis.

  12. Prognostic value of EEG in different etiological types of coma.

    Science.gov (United States)

    Khaburzania, M; Beridze, M

    2013-06-01

    Study aimed at evaluation of prognostic value of standard EEG in different etiology of coma and the influence of etiological factor on the EEG patterns and coma outcome. Totally 175 coma patients were investigated. Patients were evaluated by Glasgow Coma Scale (GCS), clinically and by 16 channel electroencephalography. Auditory evoked potentials studied by EEG -regime for evoked potentials in patients with vegetative state (VS). Patients divided in 8 groups according to coma etiology. All patients were studied for photoreaction, brainstem reflexes, localization of sound and pain, length of coma state and outcome. Brain injury visualized by conventional CT. Outcome defined as death, VS, recovery with disability and without disability. Disability was rated by Disability Rating Scale (DRS). Recovered patients assessed by Mini Mental State Examination (MMSE) scale. Statistics performed by SPSS-11.0. From 175 coma patients 55 patients died, 23 patients found in VS, 97 patients recovered with and without disability. In all etiological groups of coma the background EEG patterns were established. Correspondence analysis of all investigated factors revealed that sound localization had the significant association with EEG delta and theta rhythms and with recovery from coma state (Chi-sqr. =31.10493; p= 0.000001). Among 23 VS patients 9 patients had the signs of MCS and showed the long latency waves (p300) after binaural stimulation. The high amplitude theta frequencies in frontal and temporal lobes significantly correlated with prolongation of latency of cognitive evoked potentials (r=+0.47; pcoma outcome only in hemorrhagic and traumatic coma (chi-sqr.=12.95; pcoma outcome. Low amplitude decreased power delta and theta frequencies correlated with SND in survived coma patients (r=+0.21; pcoma patients with a high probability to recover as well as those patients, who are at high risk of SND in case of recovery from coma state.

  13. Anti-inflammatory effects of novel barbituric acid derivatives in T lymphocytes.

    Science.gov (United States)

    Xu, Chenjia; Wyman, Arlene R; Alaamery, Manal A; Argueta, Shannon A; Ivey, F Douglas; Meyers, John A; Lerner, Adam; Burdo, Tricia H; Connolly, Timothy; Hoffman, Charles S; Chiles, Thomas C

    2016-09-01

    We have used a high throughput small molecule screen, using a fission yeast-based assay, to identify novel phosphodiesterase 7 (PDE7) inhibitors. One of the most effective hit compounds was BC12, a barbituric acid-based molecule that exhibits unusually potent immunosuppressive and immunomodulatory actions on T lymphocyte function, including inhibition of T cell proliferation and IL-2 cytokine production. BC12 treatment confers a >95% inhibition of IL-2 secretion in phytohaemagglutinin (PHA) plus phorbol-12-myristate-13-acetate (PMA) stimulated Jurkat T cells. The effect of BC12 on IL-2 secretion is not due to decreased cell viability; rather, BC12 blocks up-regulation of IL-2 transcription in activated T cells. BC12 also inhibits IL-2 secretion in human peripheral T lymphocytes stimulated in response to CD3/CD28 co-ligation or the combination of PMA and ionomycin, as well as the proliferation of primary murine T cells stimulated with PMA and ionomycin. A BC12 analog that lacks PDE7 inhibitory activity (BC12-4) displays similar biological activity, suggesting that BC12 does not act via PDE7 inhibition. To investigate the mechanism of inhibition of IL-2 production by BC12, we performed microarray analyses using unstimulated and stimulated Jurkat T cells in the presence or absence of BC12 or BC12-4. Our studies show these compounds affect the transcriptional response to stimulation and act via one or more shared targets to produce both anti-inflammatory and pro-stress effects. These results demonstrate potent immunomodulatory activity for BC12 and BC12-4 in T lymphocytes and suggest a potential clinical use as an immunotherapeutic to treat T lymphocyte-mediated diseases.

  14. Multifactorial hypoglycaemic coma in female bodybuilder.

    Science.gov (United States)

    Sein Anand, Jacek; Chodorowski, Zygmunt; Wiśniewski, Marek

    2005-01-01

    A 31-year-old female bodybuilder who was admitted to the Clinic because of deep coma and hypoglycaemia was presented. For last six weeks she had been preparing for a competition doing aerobic and anaerobic exercises, ingesting rich-protein and low-carbohydrate diet and administering a low dose of somatotropin every day. Even for the regional competitions there is a need for exact doping check among young athletes. Growth hormone in a small dosage taken together with low-carbohydrate and rich-protein diet can provoke deep hypoglicemia among people who use it for doping purposes.

  15. Coma mixedematoso y midazolam: Reporte de caso.

    OpenAIRE

    PINTO VALDIVIA, Miguel; Vásquez Kunze, Sergio; Pinto Valdivia, José Luis; VILLENA CHÁVEZ, Jaime

    2012-01-01

    Se reporta el caso de un paciente varón sin antecedente previo de patología tiroidea que ingresó por coma mixedematoso y desarrolló insuficiencia respiratoria después de la administración endovenosa de midazolam. Tenía 55 años de edad, y una enfermedad de dos semanas caracterizado por letargia, debilidad, hiporexia y cefalea. Los análisis de laboratorio mostraron anemia, hiponatremia severa y niveles elevados de transaminasas y creatinquinasa. TSH elevada y T4 y T3 en niveles muy bajos. Se in...

  16. Modeling the Radiance from coma/jets: Application to Tempel 1 coma and Enceladus jets

    Science.gov (United States)

    Rinaldi, G.; Blecka, M. I.; Capaccioni, F.; Filacchione, G.; Raponi, A.

    2012-12-01

    We will describe our model for the determination of the radiance from a cometary coma, composed of dust and gases, under different illumination conditions, gas and particle compositions and abundances. The study of dust/ice and gas in the coma is one of the major goals of the VIRTIS (Visible and Infrared Thermal Imaging Spectrometer) instrument, an imaging spectrometer onboard of the Rosetta spacecraft working in the spectral range of 0.25-5 μm. The Rosetta S/C will encounter the comet 67P/CG in mid-2014 at a distance of about 3.25AU and it will follow the comet for more than year during its trajectory around the Sun. The results of our model are the synthetic spectra, in the VIRTIS spectral range, computed at different distances from the sun and with different dust grains models (size distribution, composition and vertical distribution), taken from the literature. The gases composition, spatial distribution and coma properties are provided by the Inner Coma Environment Simulation tools (ICES) available at http://ices.engin.umich.edu/. The synthetic spectra derived are presently used to forecast the signal expected at the instrument and to correctly plan the observations at the comet. It will also be used to interpret the spectra obtained during the observation phases at the comet 67/P. As a validation of our model we have applied it to the infrared observations of the coma of the comet Tempel 1 performed by HRII onboard the Deep Impact spacecraft and to the available infrared data obtained from the Cassini-VIMS instrument during the fly-byes with the Saturn's moon Enceladus. The Cassini instruments results have shown jets that spew from the below the surface and consist of both water vapor, icy particles and several organic compounds.

  17. [Complete recovery from transient coma in bilateral paramedian thalamic infarctions].

    Science.gov (United States)

    Casado, J L; Arenas, C; Serrano, V; Moreno Rojas, A; Gil-Néciga, E; Gil-Peralta, A

    1995-01-01

    Bilateral paramedian thalamic infarcts (BPTI) can begin clinically with transient coma, after which symptoms of fluctuating hypersomnolence, irrational behaviour, or amnesic states may be observed. We present two patients with BPTI who began with coma, recovering spontaneously in under eight hours, with no accompanying symptoms.

  18. [The coma awakening unit, between intensive care and rehabilitation].

    Science.gov (United States)

    Mimouni, Arnaud

    2015-01-01

    After intensive care and before classic neurological rehabilitation is possible, patients in an altered state of consciousness are cared for at early stages in so-called coma awakening units. The care involves, on the one hand, the complex support of the patient's awakening from coma as a neurological and existential process, and on the other, support for their families.

  19. Radial U-band Coma galaxy luminosity functions

    NARCIS (Netherlands)

    Beijersbergen, M; Hoekstra, H; van Dokkum, PG; van der Hulst, JM; Hibbard, JE; Rupen, MP; VanGorkom, JH

    2001-01-01

    We have mapped 1.3 degree(2) of the Coma cluster from the core to beyond the NGC4839 group. Here, we present radial U-band Coma galaxy luminosity functions (LF). The central LF can be represented by a Schechter function, but the radial LFs have very different shapes. We speculate that the derived st

  20. PROGNOSTIC VALUE OF GLASGOW COMA SCALE

    Directory of Open Access Journals (Sweden)

    Shashank

    2014-03-01

    Full Text Available Organophosphorus poisoning is the most common medico toxic emergency in India. Respiratory failure is the most common complication of OP compound leading to death. Early recognition and prompt ventilation may improve survival. The aim of the study was to correlate between the clinical score described by Peradenya Organophosphorus Poisoning (POP scale, glasgow coma scale (GCS and serum Pseudocholinesterase level at presentation, ventilator requirement and the outcome. This sectional study conducted at tertiary care centre, Nagpur from October 2011 to September 2013. 40 patients fulfilled the inclusion criteria and included in the study. Majority of patients were in younger age group with male preponderance. Agriculture is the most common occupation found in the patients in the study. Mortality was found in 17.5% patients and mortality was found to be higher in patients with severe grade of Paradeniya poisoning scale (score > or = 7 and severe grade of Glasgow coma scale (score < or = 8. Patients with normal cholinesterase levels showed significantly higher chances of survival as compared to those with less than 10% of the normal cholinesterase levels. Patients with severe grade of POP scale and GCS needed ventilatory support more frequently than patients with mild to moderate grade. Thus GCS, POP scale and Pseudocholinesterase levels can very well be used in assessing prognosis and mortality of patients of OP poisoning.

  1. The JFK Coma Recovery Scale--Revised.

    Science.gov (United States)

    Kalmar, Kathleen; Giacino, Joseph T

    2005-01-01

    The JFK Coma Recovery Scale (CRS) was developed to help characterise and monitor patients functioning at Rancho Levels I-IV and has been used widely in both clinical and research settings within the US and Europe. The CRS was recently revised to address a number of concerns emanating from our own clinical experience with the scale, feedback from users and researchers as well as the results of Rasch analyses. Additionally, the CRS did not include all of the behavioural criteria necessary to diagnose the minimally conscious state (MCS), thereby limiting diagnostic utility. The revised JFK Coma Recovery Scale (CRS-R) includes addition of new items, merging of items found to be statistically similar, deletion or modification of items showing poor fit with the scale's underlying construct, renaming of items, more stringent scoring criteria, and quantification of elicited behaviours to improve accuracy of rating. Psychometric properties of the CRS-R appear to meet standards for measurement and evaluation tools for use in clinical and research settings, and diagnostic application suggests that the scale is capable of discriminating patients in the minimally conscious state from those in the vegetative state.

  2. Infrared Luminosity Function of the Coma Cluster

    CERN Document Server

    Bai, L; Rieke, M J; Hinz, J L; Kelly, D M; Blaylock, M; Bai, Lei; Rieke, George H.; Rieke, Marcia J.; Hinz, Joannah L.; Kelly, Douglas M.; Blaylock, Myra

    2006-01-01

    Using mid-IR and optical data, we deduce the total infrared (IR) luminosities of galaxies in the Coma cluster and present their infrared luminosity function (LF). The shape of the overall Coma IR LF does not show significant differences from the IR LFs of the general field, which indicates the general independence of global galaxy star formation on environment up to densities $\\sim$ 40 times greater than in the field (we cannot test such independence above $L_{ir} \\approx 10^{44} {\\rm ergs s}^{-1}$). However, a shallower faint end slope and a smaller $L_{ir}^{*}$ are found in the core region (where the densities are still higher) compared to the outskirt region of the cluster, and most of the brightest IR galaxies are found outside of the core region. The IR LF in the NGC 4839 group region does not show any unique characteristics. By integrating the IR LF, we find a total star formation rate in the cluster of about 97.0 $M_{\\sun}{\\rm yr}^{-1}$. We also studied the contributions of early- and late-type galaxie...

  3. Synthesis of New Azo Dyes and Copper(II) Complexes Derived from Barbituric Acid and 4-Aminobenzoylhydrazone

    OpenAIRE

    GUP, Bülent KIRKAN and Ramazan

    2008-01-01

    Four new azo dyes, L1, L2, L3, and L4, were prepared by linking benzaldehyde p-aminobenzoylhydrazone (3) and p-hydroxybenzaldehyede p--aminobenzoylhydrazone (4) to barbituric acid and 1,3-dimethylbarbituric acid through diazo-coupling reactions. Reactions of the azo-dyes with copper chloride and bidentate ligand, 1,10-phenanthroline, produced mixed-ligand dinuclear complexes with general stoichiometry [Cu2L(phen)2]Cl2 (7, 8, 9, and 10). The structures of both azo dyes and their compl...

  4. Synthesis of barbituric acid containing nucleotides and their implications for the origin of primitive informational polymers.

    Science.gov (United States)

    Mungi, Chaitanya V; Singh, Sachin Kumar; Chugh, Jeetender; Rajamani, Sudha

    2016-07-27

    Given that all processes in modern biology are encoded and orchestrated by polymers, the origin of informational molecules had to be a crucial and significant step in the origin of life on Earth. An important molecule in this context is RNA that is thought to have allowed the transition from chemistry to biology. However, the RNA molecule is comprised of intramolecular bonds which are prone to hydrolysis, especially so under the harsh conditions of the early Earth. Furthermore, the formation of nucleotides with extant bases and their subsequent polymerization have both been problematic, to say the least. Alternate heterocycles, in contrast, have resulted in nucleosides in higher yields, suggesting a viable and prebiotically relevant solution to the longstanding "nucleoside problem". In the present study, we have synthesized a nucleotide using ribose 5'-monophosphate (rMP) and barbituric acid (BA), as the base analog, using dry-heating conditions that are thought to be prevalent in several regimes of the early Earth. Polymerization of the resultant monomers, i.e. BA-nucleotides, was also observed when dehydration-rehydration cycles were carried out at low pH and high temperature. The resulting RNA-like oligomers have intact bases unlike in reactions that were carried out with canonical nucleotides, which resulted in abasic sites under acidic conditions due to cleavage of the N-glycosidic linkages. Furthermore, the incorporation of BA directly into preformed sugar-phosphate backbones was also observed when rMP oligomers were subjected to heating with BA. The results from our aforementioned experiments provide preliminary evidence that BA could have been a putative precursor of modern nucleobases, which could have been incorporated into primitive informational polymers that predated the molecules of an RNA world. Moreover, they also highlight that the prebiotic soup, which would have been replete with alternate heterocycles, could have allowed the sampling of other

  5. Synthesis and Evaluation of Changes Induced by Solvent and Substituent in Electronic Absorption Spectra of New Azo Disperse Dyes Containig Barbiturate Ring

    Directory of Open Access Journals (Sweden)

    Hooshang Hamidian

    2013-01-01

    Full Text Available Six azo disperse dyes were prepared by diazotizing 4-amino hippuric acid and coupled with barbituric acid and 2-thiobarbituric acid. Then, the products were reacted with aromatic aldehyde, sodium acetate, and acetic anhydride, and oxazolone derivatives were formed. Characterization of the dyes was carried out by using UV-Vis, FT-IR, 1H NMR and 13C NMR, and mass spectroscopic techniques. The solvatochromic behavior of azo disperse dyes was evaluated in various solvents. The effects of substituents of aromatic aldehyde, barbiturate, and thiobarbiturate ring on the color of dyes were investigated.

  6. Testing chameleon gravity with the Coma cluster

    CERN Document Server

    Terukina, Ayumu; Yamamoto, Kazuhiro; Bacon, David; Koyama, Kazuya; Nichol, Robert C

    2013-01-01

    We propose a novel method to test the gravitational interactions in the outskirts of galaxy clusters. When gravity is modified, this is typically accompanied by an introduction of an additional scalar degree of freedom, which mediates an attractive fifth force. The presence of an extra gravitational coupling, however, is tightly constrained by local measurements. In chameleon modifications of gravity, local tests can be evaded by employing a screening mechanism that suppresses the fifth force in dense environments. While the chameleon field may be screened in the interior of the cluster, its outer region can still be affected by the extra force, introducing a deviation between the hydrostatic and lensing mass of the cluster. Thus, the chameleon modification can be tested by combining the gas and lensing measurements of the cluster. We demonstrate the operability of our method with the Coma cluster, for which both a lensing measurement and gas observations from the X-ray surface brightness, the X-ray temperatu...

  7. FK Comae Berenices, King of Spin

    DEFF Research Database (Denmark)

    Ayres, Thomas R.; Kashyap, V.; Saar, S.

    2016-01-01

    COCOA-PUFS is an energy-diverse, time-domain study of the ultra-fast spinning, heavily spotted, yellow giant FK Comae Berenices (FK Com: HD117555; G4 III). This single star is thought to be a recent binary merger, and is exceptionally active by measure of its intense ultraviolet (UV) and X......-ray emissions, and proclivity to flare. COCOA-PUFS was carried out with the Hubble Space Telescope in the UV (1200-3000 Å), using mainly its high-performance Cosmic Origins Spectrograph, but also high precision Space Telescope Imaging Spectrograph; Chandra X-ray Observatory in the soft X-rays (0.5-10 ke......V), utilizing its High-Energy Transmission Grating Spectrometer; together with supporting photometry and spectropolarimetry in the visible from the ground. This is an introductory report on the project. FK Com displayed variability on a wide range of timescales over all wavelengths during the week-long main...

  8. Flumazenil, naloxone and the 'coma cocktail'.

    Science.gov (United States)

    Sivilotti, Marco L A

    2016-03-01

    Flumazenil and naloxone are considered to be pharmacologically ideal antidotes. By competitive binding at the molecular target receptors, they are highly specific antagonists of two important drug classes, the benzodiazepines and opioids, respectively. Both antidotes enjoy rapid onset and short duration after parenteral administration, are easily titrated and are essentially devoid of agonist effects. Yet only naloxone is widely used as a component of the 'coma cocktail', a sequence of empirical treatments to correct altered mental status, while experts discourage the use of flumazenil for such patients. This review contrasts the history, indications, published evidence and novel applications for each antidote in order to explain this disparity in the clinical use of these 'ideal' antidotes.

  9. [Predicting prognosis in post-anoxic coma].

    Science.gov (United States)

    Kirsch, M; Boveroux, P; Massion, P; Sadzot, B; Boly, M; Lambermont, B; Lamy, M; Damas, P; Damas, F; Moonen, G; Laureys, S; Ledoux, D

    2008-01-01

    Most patients who remain comatose for a few hours after a period of global cerebral ischemia have a poor prognosis. Early identification of these patients is desirable to reduce uncertainty about treatment and non-treatment decisions, and to improve relationships with the family. The absence of pupillary light response and corneal reflexes, absent or stereotyped extension motor response to noxious stimulation (3 days after insult); myoclonus status epilepticus; absence of cortical N20 response on somatosensory evoked potential studies; generalised suppression or burst-suppression EEG and serum neuron-specific enolase above 33 microg/L (sampled 1-3 days after insult) have been shown to predict poor outcome. We here propose an algorithm to help intensive care physicians' clinical decision making in post-anoxic coma.

  10. Brain connectivity in pathological and pharmacological coma

    Directory of Open Access Journals (Sweden)

    Quentin Noirhomme

    2010-12-01

    Full Text Available Recent studies in patients with disorders of consciousness (DOC tend to support the view that awareness is not related to activity in a single brain region but to thalamo-cortical connectivity in the frontoparietal network. Functional neuroimaging studies have shown preserved albeit disconnected low level cortical activation in response to external stimulation in patients in a vegetative state or unresponsive wakefulness syndrome. While activation of these primary sensory cortices does not necessarily reflect conscious awareness, activation in higher order associative cortices in minimally conscious state patients seems to herald some residual perceptual awareness. PET studies have identified a metabolic dysfunction in a widespread fronto-parietal global neuronal workspace in DOC patients including the midline default mode network, ‘intrinsic’ system, and the lateral frontoparietal cortices or ‘extrinsic system’. Recent studies have investigated the relation of awareness to the functional connectivity within intrinsic and extrinsic networks, and with the thalami in both pathological and pharmacological coma. In brain damaged patients, connectivity in all default network areas was found to be non-linearly correlated with the degree of clinical consciousness impairment, ranging from healthy controls and locked-in syndrome to minimally conscious, vegetative, coma and brain dead patients. Anesthesia-induced loss of consciousness was also shown to correlate with a global decrease in cortico-cortical and thalamo-cortical connectivity in both intrinsic and extrinsic networks, but not in auditory or visual networks. In anesthesia, unconsciousness was also associated with a loss of cross-modal interactions between networks. These results suggest that conscious awareness critically depends on the functional integrity of thalamo-cortical and cortico-cortical frontoparietal connectivity within and between intrinsic and extrinsic brain networks.

  11. Ultra-Compact Dwarfs in the Coma Cluster

    CERN Document Server

    Chiboucas, Kristin; Marzke, Ronald O; Phillipps, Steve; Price, James; Peng, Eric; Trentham, Neil; Carter, David; Hammer, Derek

    2011-01-01

    We have undertaken a spectroscopic search for ultra compact dwarf galaxies (UCDs) in the dense core of the dynamically evolved, massive Coma cluster as part of the HST/ACS Coma Cluster Treasury Survey. UCD candidates were initially chosen based on color, magnitude, degree of resolution within the ACS images, and the known properties of Fornax and Virgo UCDs. Follow-up spectroscopy with Keck/LRIS confirmed 27 candidates as members of the Coma Cluster, a success rate > 60% for targeted objects brighter than M_R = -12. Another 14 candidates may also prove to be Coma members, but low signal-to-noise spectra prevent definitive conclusions. An investigation of the properties and distribution of the Coma UCDs finds these objects to be very similar to UCDs discovered in other environments. The Coma UCDs tend to be clustered around giant galaxies in the cluster core and have colors/metallicity that correlate with the host galaxy. With properties and a distribution similar to that of the Coma cluster globular cluster p...

  12. Which EEG patterns in coma are nonconvulsive status epilepticus?

    Science.gov (United States)

    Trinka, Eugen; Leitinger, Markus

    2015-08-01

    Nonconvulsive status epilepticus (NCSE) is common in patients with coma with a prevalence between 5% and 48%. Patients in deep coma may exhibit epileptiform EEG patterns, such as generalized periodic spikes, and there is an ongoing debate about the relationship of these patterns and NCSE. The purposes of this review are (i) to discuss the various EEG patterns found in coma, its fluctuations, and transitions and (ii) to propose modified criteria for NCSE in coma. Classical coma patterns such as diffuse polymorphic delta activity, spindle coma, alpha/theta coma, low output voltage, or burst suppression do not reflect NCSE. Any ictal patterns with a typical spatiotemporal evolution or epileptiform discharges faster than 2.5 Hz in a comatose patient reflect nonconvulsive seizures or NCSE and should be treated. Generalized periodic diacharges or lateralized periodic discharges (GPDs/LPDs) with a frequency of less than 2.5 Hz or rhythmic discharges (RDs) faster than 0.5 Hz are the borderland of NCSE in coma. In these cases, at least one of the additional criteria is needed to diagnose NCSE (a) subtle clinical ictal phenomena, (b) typical spatiotemporal evolution, or (c) response to antiepileptic drug treatment. There is currently no consensus about how long these patterns must be present to qualify for NCSE, and the distinction from nonconvulsive seizures in patients with critical illness or in comatose patients seems arbitrary. The Salzburg Consensus Criteria for NCSE [1] have been modified according to the Standardized Terminology of the American Clinical Neurophysiology Society [2] and validated in three different cohorts, with a sensitivity of 97.2%, a specificity of 95.9%, and a diagnostic accuracy of 96.3% in patients with clinical signs of NCSE. Their diagnostic utility in different cohorts with patients in deep coma has to be studied in the future. This article is part of a Special Issue entitled "Status Epilepticus".

  13. Chronic disorders of consciousness following coma: Part one: medical issues.

    Science.gov (United States)

    Luce, John M

    2013-10-01

    Increasing numbers of patients survive traumatic brain injury (TBI) and cardiopulmonary arrest and resuscitation and are admitted to the ICU in coma. Some of these patients become brain dead; others regain consciousness. Still others become vegetative or minimally conscious, conditions called chronic disorders of consciousness and ultimately are cared for outside the ICU. Comatose patients lack the wakefulness and awareness that distinguish consciousness from unconsciousness. Vegetative patients are awake in that they manifest sleep-wake cycles, but they are unaware of their environment and cannot respond to stimuli. Minimally conscious patients are awake, aware to a limited extent, and somewhat responsive. The diagnosis of the vegetative and minimally conscious states has been based largely on their behavioral and pathologic features, and it has been believed that vegetative patients remain in that condition permanently. Nevertheless, EEG and neuroimaging studies suggest that the traditional diagnostic approach is imprecise. Moreover, clinical investigations have revealed that some vegetative patients can become minimally conscious and that some minimally conscious patients can gain increased awareness. Few therapies for patients with chronic disorders of consciousness have been subjected to randomized trials. Furthermore, although a small number of patients have improved neurologically with or without treatment, their overall prognosis for neurologic recovery remains poor.

  14. [Coma in type 2 diabete mellitus on metformin treatment].

    Science.gov (United States)

    Renard, C; Tellal, S; Fevre, G; Ragot, C; Vest, P; Foissaud, V; Renaudeau, C

    2003-01-01

    Non traumatic coma in diabete mellitus has two origins : hypo- or hyperglycemia. Coma with hyperglycemia can be due to ketoacidosis, hyperosmolar state or lactic acidosis. The present observation reports on a type 2 diabete mellitus patient presenting with a coma while the patient was on metformin and glibenclamide treatment. On admission, biologicals tests showed major acidosis, hyperglycemia and hyperosmolarity. No metformine accumulation was demonstrated by analytical measure. In this case, the association of hyperosmolar state and metabolic acidosis prove the difficulty of the differential diagnosis.

  15. Valproic acid-induced hyperammonaemic coma and unrecognised portosystemic shunt.

    Science.gov (United States)

    Nzwalo, Hipólito; Carrapatoso, Leonor; Ferreira, Fátima; Basilio, Carlos

    2013-06-01

    Hyperammonaemic encephalopathy is a rare and potentially fatal complication of valproic acid treatment. The clinical presentation of hyperammonaemic encephalopathy is wide and includes seizures and coma. We present a case of hyperammonaemic coma precipitated by sodium valproate use for symptomatic epilepsy in a patient with unrecognised portosystemic shunt, secondary to earlier alcoholism. The absence of any stigmata of chronic liver disease and laboratory markers of liver dysfunction delayed the recognition of this alcohol-related complication. The portal vein bypass led to a refractory, valproic acid-induced hyperammonaemic coma. The patient fully recovered after dialysis treatment.

  16. Reliability of self-reported use of amphetamine, barbiturates, benzodiazepines, cannabinoids, cocaine, methadone, and opiates among acutely hospitalized elderly medical patients

    DEFF Research Database (Denmark)

    Glintborg, B.; Olsen, L.; Poulsen, H.

    2008-01-01

    Undisclosed use of illicit drugs and prescription controlled substances is frequent in some settings. The aim of the present study was to estimate the reliability of self-reported use of amphetamine, barbiturates, benzodiazepines, cannabinoids, cocaine, methadone, and opiates among acutely...

  17. How do you know when your patient is "waking up": coma recovery assessment in a complex continuing care setting.

    Science.gov (United States)

    Lee, Teresa M; Savage, Julie; McKee, Hilary; Flament, Marie-Pierre; D'Onofrio, Silvia; Eckert, Suzanne

    2013-01-01

    Coma, vegetative state (VS) and minimally conscious state (MCS) are disastrous outcomes following severe traumatic brain injury. Due to the extent of the resultant neurological deficits including hemisphere damage, loss of cellular integrity, altered and abnormal movements such as flexor and extensor patterns, and alterations in cranial nerve function, it can become difficult for the interprofessional team to identify when a patient is emerging from their coma. The Glasgow Coma Scale (GCS), commonly used to assess patients with traumatic brain injury (TBI) is not comprehensive or sensitive enough to provide concrete evidence that a patient is emerging from VS to an MCS. The purpose of this paper is to present a case study of a patient who has emerged from a persistent VS to promote a deeper understanding of what is involved when working with this clientele. Challenges in assessment of cognitive functioning, the development of successful communication through the use of technology and the goals of therapy amongst the various health team members will be provided. Collaborative support with the family will also be discussed. Members of the interprofessional team explored the literature to determine coma recovery assessment tools and best evidence guidelines to direct their interventions with this patient.

  18. [cerebral Hemometabolism: Variability In The Acute Phase Of Traumatic Coma].

    OpenAIRE

    Falcão,A. L.; Araújo, S; Dragosavac, D; Terzi, R G; Thiesen, R A; Cintra, E A; Sardinha, L A; Capone Neto, A; Dantas Filho, V P; Quagliato, E M

    2015-01-01

    to evaluate the interrelationships between cerebral and systemic hemometabolic alterations in patients with severe traumatic brain injury managed according to a standardized therapeutic protocol. prospective, interventional study in patients with traumatic coma. a general Intensive Care Unit in a teaching hospital. twenty-seven patients (21M e 6F), aging 14 - 58 years, with severe acute brain trauma, presenting with three to eight points on the Glasgow Coma Scale, were prospectively evaluated...

  19. Cometary Coma Chemical Composition (C4) Mission

    Science.gov (United States)

    Carle, Glenn C.; Clark, Benton C.; Knocke, Philip C.; OHara, Bonnie J.; Adams, Larry; Niemann, Hasso B.; Alexander, Merle; Veverka, Joseph; Goldstein, Raymond; Huebner, Walter; Morrison, David (Technical Monitor)

    1994-01-01

    Cometary exploration remains of great importance to virtually all of space science. Because comets are presumed to be remnants of the early solar nebula, they are expected to provide fundamental knowledge as to the origin and development of the solar system as well as to be key to understanding of the source of volatiles and even life itself in the inner solar system. Clearly the time for a detailed study of the composition of these apparent messages from the past has come. A comet rendezvous mission, the Cometary Coma Chemical Composition (C4) Mission, is now being studied as a candidate for the new Discovery program. This mission is a highly-focussed and usefully-limited subset of the Cometary Rendezvous Asteroid Flyby (CRAF) Mission. The C4 mission will concentrate on measurements that will produce an understanding of the composition and physical makeup of a cometary nucleus. The core science goals of the C4 mission are 1) to determine the chemical, elemental, and isotopic composition of a cometary nucleus and 2) to characterize the chemical and isotopic nature of its atmosphere. A related goal is to obtain temporal information about the development of the cometary coma as a function of time and orbital position. The four short-period comets -- Tempel 1, Tempel 2, Churyumov-Gerasimenko, and Wirtanen -which all appear to have acceptable dust production rates, were identified as candidate targets. Mission opportunities have been identified beginning as early as 1998. Tempel I with a launch in 1999, however, remains the baseline comet for studies of and planning the C4 mission. The C4 mission incorporates two science instruments and two engineering instruments in the payload to obtain the desired measurements. The science instruments include an advanced version of the Cometary Ice and Dust Experiment (CIDEX), a mini-CIDEX with a sample collection system, an X-ray Fluorescence Spectrometer and a Pyrolysis-Gas Chromatograph, and a simplified version of the Neutral

  20. The Cores of Elliptical Galaxies in Coma

    Science.gov (United States)

    Lucey, John

    1995-07-01

    The cores of galaxies are astrophysically unique. They canhost high energy nuclei, star formation and perhaps even blackholes. HST observations have established that the cores ofellipticals are related to their global properties, and so canbe used as diagnostics of the physical processes occurring atthe time of formation. HST images of galaxy cores havedistinguished two different types of core luminosity profiles:`soft' and `hard' types. It is suggested that luminous, slowlyrotating galaxies have `soft' cores and the less luminousdisky galaxies have `hard' cores. This can be interpreted interms of a formation scenario based on a merger hierarchy inwhich the low luminosity systems experience highly dissipativemergers, but as the luminous systems are assembled the mergersbecome increasingly stellar. In this picture, the type of corea galaxy generates is intimately related to its evolutionaryhistory, i.e. the degree of interaction/merging experiencedand the availability of cold gas. In turn, this should notonly depend on luminosity but also on the galaxy's localenvironment. Here we propose to test the gaseous/stellarmerger picture by imaging a set of Coma cluster ellipticalsfrom a wide range of cluster radii. In the gas poorenvironment of the cluster core there may be insufficent coldgas for the low luminosity galaxies to form `hard' cores.Similarly, at the cluster turnround radius even luminousgalaxies may have experienced a dissipative core formation andpossess

  1. Synthesis, X-Ray Crystal Structures, Biological Evaluation, and Molecular Docking Studies of a Series of Barbiturate Derivatives

    Directory of Open Access Journals (Sweden)

    Assem Barakat

    2016-01-01

    Full Text Available A series of barbiturates derivatives synthesized and screened for different set of bioassays are described. The molecular structures of compounds 5a, 5d, and 5f were solved by single-crystal X-ray diffraction techniques. The results of bioassay show that compounds 4a, 4b, 4c, 4d, 4e, 4f, and 4g are potent antioxidants in comparison to the tested standards, butylated hydroxytoluene (BHT, and N-acetylcysteine. Compounds 4a–4e (IC50=101.8±0.8–124.4±4.4 μM and 4g (IC50=104.1±1.9 μM were more potent antioxidants than the standard (BHT, IC50=128.8±2.1 μM. The enzyme inhibition potential of these compounds was also evaluated, in vitro, against thymidine phosphorylase, α-glucosidase, and β-glucuronidase enzymes. Compounds 4c, 4h, 4o, 4p, 4q, 5f, and 5m were found to be potent α-glucosidase inhibitors and showed more activity than the standard drug acarbose, whereas compounds 4v, and 5h were found to be potent thymidine phosphorylase inhibitors, more active than the standard drug, 7-deazaxanthine. All barbiturates derivatives (4a–4x, 4z, and 5a–5m were found to be noncytotoxic against human prostate (PC-3, Henrietta Lacks cervical (HeLa and Michigan Cancer Foundation-7 breast (MCF-7 cancer cell lines, and 3T3 normal fibroblast cell line, except 4y which was cytotoxic against all the cell lines.

  2. Clinical Practice Guidelines for Coma Management Guía de práctica clínica para el tratamiento del coma

    Directory of Open Access Journals (Sweden)

    Tania Pérez Ramos

    2009-03-01

    Full Text Available Clinical Practice Guidelines for Coma Management. It has been defined as acute alteration of wakefulness state, in which patients have a primitive response (or no response at all to nociceptive stimulus without waking up and could reach the total absence of all reflex. This document includes a review and update of the main clinical aspects, concepts, aetiology and therapy for this condition. It includes assessment guidelines focused on the most important aspects to be accomplished.Guía de práctica clínica para el tratamiento del paciente en coma. Definido como la alteración aguda del estado de vigilia en la cual los pacientes responden primitivamente o no responden a los estímulos nociceptivos, sin despertarse, que puede llegar a la ausencia de todos los reflejos. El documento revisa y actualiza los aspectos clínicos fundamentales, conceptos, etiología y el tratamiento terapéutico. Concluye con su guía de evaluación, enfocada en los aspectos más importantes a cumplir.

  3. Lesson of the month 2: a case of coma in a Parkinson's patient: a combination of fatigue, dehydration and high protein diet over the New Year period?

    Science.gov (United States)

    Arulanantham, Nirmalan; Lee, Ralph Wing Fung; Hayton, Tom

    2014-08-01

    Although motor fluctuation can often be severe in Parkinson's disease (PD), it is rare for an 'off period' to result in coma. The case presented here is of a patient with longstanding PD who was admitted to our hospital with a Glasgow Coma Scale of three after missing just one or two doses of her medication. Investigation for infective, neurovascular and metabolic causes of coma were negative and the patient recovered very rapidly following reinstitution of dopaminergic therapy via nasogastric tube. This case highlights how florid the presentation of motor fluctuations in PD can be and the importance of restarting treatment as quickly as possible. Guidance is provided on how to administer dopaminergic medications in patients who are unable to swallow.

  4. Warm-Hot Intergalactic Medium Associated with the Coma Cluster

    CERN Document Server

    Takei, Y; Finoguenov, A; Mitsuda, K; Tamura, T; Fujimoto, R; Briel, U G; Takei, Yoh; Finoguenov, Alexis; Mitsuda, Kazuhisa; Tamura, Takayuki; Fujimoto, Ryuichi; Briel, Ulrich G.

    2006-01-01

    We present our XMM-Newton RGS observations of X Comae, an AGN behind the Coma cluster. We detect absorption by NeIX and OVIII at the redshift of Coma with an equivalent width of 3.3+/-1.8 eV and 1.7+/-1.3 eV, respectively (90% confidence errors or 2.3 sigma and 1.9 sigma confidence detections determined from Monte Carlo simulations). The combined significance of both lines is 3.0 sigma, again determined from Monte Carlo simulations. The same observation yields a high statistics EPIC spectrum of the Coma cluster gas at the position of X Comae. We detect emission by NeIX with a flux of 2.5+/-1.2 x 10^-8 photons cm^-2 s^-1 arcmin^-2 (90% confidence errors or 3.4 sigma confidence detection). These data permit a number of diagnostics to determine the properties of the material causing the absorption and producing the emission. Although a wide range of properties is permitted, values near the midpoint of the range are T = 4 x 10^6 K, n_H = 6 x 10^-6 cm^-3 corresponding to an overdensity with respect to the mean of ...

  5. Bacteriology of aspiration pneumonia in patients with acute coma.

    Science.gov (United States)

    Lauterbach, Enise; Voss, Frederik; Gerigk, Roland; Lauterbach, Michael

    2014-12-01

    Loss of protective airway reflexes in patients with acute coma puts these patients at risk of aspiration pneumonia complicating the course of the primary disease. Available data vary considerably with regard to bacteriology, role of anaerobic bacteria, and antibiotic treatment. Our objective was to research the bacteriology of aspiration pneumonia in acute coma patients who were not pre-treated with antibiotics or hospitalized within 30 days prior to the event. We prospectively analyzed 127 patient records from adult patients admitted, intubated and ventilated to a tertiary medical intensive care unit with acute coma. Bacteriology and antibiotic resistance testing from tracheal aspirate sampled within 24 h after admission, blood cultures, ICU scores (APACHE II, SOFA), hematology, and clinical chemistry were assessed. Patients were followed up until death or hospital discharge. The majority of patients with acute coma suffered from acute cardiovascular disorders, predominantly myocardial infarction, followed by poisonings, and coma of unknown cause. In a majority of our patients, microaspiration resulted in overt infection. Most frequently S. aureus, H. influenzae, and S. pneumoniae were isolated. Anaerobic bacteria (Bacteroides spec., Fusobacteria, Prevotella spec.) were isolated from tracheal aspirate in a minority of patients, and predominantly as part of a mixed infection. Antibiotic monotherapy with a 2nd generation cephalosporin, or a 3rd generation gyrase inhibitor, was most effective in our patients regardless of the presence of anaerobic bacteria.

  6. Immunohistochemical investigation of the coma blister and its pathogenesis.

    Science.gov (United States)

    Kashiwagi, Masayuki; Ishigami, Akiko; Hara, Kenji; Matsusue, Aya; Waters, Brian; Takayama, Mio; Tokunaga, Itsuo; Nishimura, Akiyoshi; Kubo, Shin-ichi

    2013-01-01

    The erythematous patches and vesicles that are observed in coma patients, usually from an overdose of medication, are known as coma blisters. However, it is unknown whether the degenerated sweat gland is a necrosis or apoptosis. We immunohistochemically examined such skin lesions to investigate the characteristics and pathogenesis of the coma blister. Skin lesions were obtained from a forensic autopsy case, a woman in her thirties, of caffeine intoxication. Those lesions were observed in the left femoral, the lower left thigh, and the right knee. Histologically, the skin lesions showed that the keratinocytes had necrosed and the epidermis was thin in some areas. Eccrine sweat gland degeneration was observed. Obvious inflammatory cell infiltrations were not detected. Immunohistochemically, we stained each skin lesion against CD3, CD8, CD45RO, cytokeratin, 70 kD heat shock protein, ubiquitin, 150 kD oxygen regulated protein, and caspase-cleaved keratin 18 neo-epitope M30. They were also stained with an in situ apoptosis detection kit. Degenerated sweat glands featured CD45RO and M30 immunoreactivity. Immunohistochemical staining for CD45RO, CK-L, and M30 might be useful to observe sweat gland degeneration in the coma blister. Therefore, the apoptosis might be related to coma blisters and sweat gland degenerations.

  7. Coma hiperosmolar associado ao transplante de fígado Hyperosmolar coma associated with liver transplantation

    Directory of Open Access Journals (Sweden)

    Olival Cirilo Lucena da Fonseca-Neto

    2009-03-01

    Full Text Available INTRODUÇÃO: O diagnóstico diferencial dos pacientes inconscientes sempre inclui o coma hiperosmolar hiperglicêmico não-cetótico. RELATO DE CASO: Paciente do sexo feminino, 22 anos, tipo sangüíneo O+, branca, natural e procedente do Recife - PE com queixa de icterícia e astenia há um mês. Ao exame físico, havia icterícia 3+/4+, desnutrição leve (IMC 17,5 e asterixis. Os exames laboratoriais sugeriram hepatite fulminante. Após 12 horas da inclusão na lista de espera pelo transplante, recebeu enxerto de fígado de doador cadáver, mediante o uso de técnica de piggback sem intercorrências. No 10º dia pós-operatório evoluiu com trombose de artéria hepática (TAH, diagnosticada por ultra-som com doppler de artéria hepática. Após 48 horas foi retransplantada sem intercorrências. A partir do 13º dia de pós-operatório, evoluiu com hiperglicemia grave (> 600 mg/dl e alteração do nível de consciência (9 pontos na escala de coma de Glasgow. Osmolaridade sérica nesse momento igual a 309 mOsm/kgH2O. O nível sérico de tacrolimus nesse dia foi de 11 ng/dl. Coma hiperosmolar hiperglicêmico não-cetótico foi tratado clinicamente por 48 horas. Recebeu alta no 30º dia de pós-operatório do retransplante, sem diabete mellitus. CONCLUSÃO: O coma hiperosmolar é um evento raro no pós-operatório de transplante de fígado e pode modificar a evolução do paciente.BACKGROUND: The literature described an increased incidence of gastrointestinal stromal tumors (GISTs in patients with neurofibromatosis type 1. These tumors typically occur in the small intestine, and frequently are multiple. Often the behavior of the tumor in this association is more favorable than in sporadic cases. CASE REPORT: Incidental diagnosis of GIST was done in a patient with neurofibromatosis type 1 during treatment for acute abdomen. Trans-operatively was identified a retrocecal perforated appendicitis and a neoplastic mass in the proximal jejunum. The

  8. The HST/ACS Coma Cluster Survey. VIII. Barred Disk Galaxies in the Core of the Coma Cluster

    CERN Document Server

    Marinova, Irina; Weinzirl, Tim; Erwin, Peter; Trentham, Neil; Ferguson, Henry C; Hammer, Derek; Brok, Mark den; Graham, Alister W; Carter, David; Balcells, Marc; Goudfrooij, Paul; Guzman, Rafael; Hoyos, Carlos; Mobasher, Bahram; Mouhcine, Mustapha; Peletier, Reynier F; Peng, Eric; Kleijn, Gijs Verdoes

    2012-01-01

    (ABRIDGED) We use high resolution (~0.1") F814W ACS images from the HST ACS Treasury survey of the Coma cluster at z~0.02 to study bars in massive disk galaxies (S0s), and in dwarf galaxies in the Coma core. Our study helps constrain the evolution of bars and disks in dense environments and provides a comparison point for studies in lower density environments and at higher redshifts. (1) We characterize the fraction and properties of bars in a sample of 32 bright (M_V 10^9.5 M_sun) S0 galaxies, which dominate the population of massive disk galaxies in the Coma core. Measuring the S0 bar fraction must be handled carefully, as the results depend on the method used: the bar fraction for bright S0s in the Coma core is 50%+/-11%, 65%+/-11%, and 60%+/-11% for three methods of bar detection: strict ellipse fit criteria, relaxed ellipse fit criteria, and visual classification. (2) We compare the S0 bar fraction across different environments (Coma core, A901/902, Virgo). We find that the bar fraction among bright S0 ...

  9. Extragalactic Gamma Ray Excess from Coma Supercluster Direction

    Indian Academy of Sciences (India)

    Pantea Davoudifar; S. Jalil Fatemi

    2011-09-01

    The origin of extragalactic diffuse gamma ray is not accurately known, especially because our suggestions are related to many models that need to be considered either to compute the galactic diffuse gamma ray intensity or to consider the contribution of other extragalactic structures while surveying a specific portion of the sky. More precise analysis of EGRET data however, makes it possible to estimate the diffuse gamma ray in Coma supercluster (i.e., Coma\\A1367 supercluster) direction with a value of ( > 30MeV) ≃ 1.9 × 10-6 cm-2 s-1, which is considered to be an upper limit for the diffuse gamma ray due to Coma supercluster. The related total intensity (on average) is calculated to be ∼ 5% of the actual diffuse extragalactic background. The calculated intensity makes it possible to estimate the origin of extragalactic diffuse gamma ray.

  10. EEG as an Indicator of Cerebral Functioning in Postanoxic Coma.

    Science.gov (United States)

    Juan, Elsa; Kaplan, Peter W; Oddo, Mauro; Rossetti, Andrea O

    2015-12-01

    Postanoxic coma after cardiac arrest is one of the most serious acute cerebral conditions and a frequent cause of admission to critical care units. Given substantial improvement of outcome over the recent years, a reliable and timely assessment of clinical evolution and prognosis is essential in this context, but may be challenging. In addition to the classic neurologic examination, EEG is increasingly emerging as an important tool to assess cerebral functions noninvasively. Although targeted temperature management and related sedation may delay clinical assessment, EEG provides accurate prognostic information in the early phase of coma. Here, the most frequently encountered EEG patterns in postanoxic coma are summarized and their relations with outcome prediction are discussed. This article also addresses the influence of targeted temperature management on brain signals and the implication of the evolution of EEG patterns over time. Finally, the article ends with a view of the future prospects for EEG in postanoxic management and prognostication.

  11. Contemporary approach to neurologic prognostication of coma after cardiac arrest.

    Science.gov (United States)

    Ben-Hamouda, Nawfel; Taccone, Fabio S; Rossetti, Andrea O; Oddo, Mauro

    2014-11-01

    Coma after cardiac arrest (CA) is an important cause of admission to the ICU. Prognosis of post-CA coma has significantly improved over the past decade, particularly because of aggressive postresuscitation care and the use of therapeutic targeted temperature management (TTM). TTM and sedatives used to maintain controlled cooling might delay neurologic reflexes and reduce the accuracy of clinical examination. In the early ICU phase, patients' good recovery may often be indistinguishable (based on neurologic examination alone) from patients who eventually will have a poor prognosis. Prognostication of post-CA coma, therefore, has evolved toward a multimodal approach that combines neurologic examination with EEG and evoked potentials. Blood biomarkers (eg, neuron-specific enolase [NSE] and soluble 100-β protein) are useful complements for coma prognostication; however, results vary among commercial laboratory assays, and applying one single cutoff level (eg, > 33 μg/L for NSE) for poor prognostication is not recommended. Neuroimaging, mainly diffusion MRI, is emerging as a promising tool for prognostication, but its precise role needs further study before it can be widely used. This multimodal approach might reduce false-positive rates of poor prognosis, thereby providing optimal prognostication of comatose CA survivors. The aim of this review is to summarize studies and the principal tools presently available for outcome prediction and to describe a practical approach to the multimodal prognostication of coma after CA, with a particular focus on neuromonitoring tools. We also propose an algorithm for the optimal use of such multimodal tools during the early ICU phase of post-CA coma.

  12. Myxoedemic coma: an uncommon presentation of Sheehan syndrome

    Directory of Open Access Journals (Sweden)

    Ramakant Rawat

    2014-06-01

    Full Text Available This is a rare case of a 35 year old multiparous female who presented with electrolyte abnormality, hyponatremia in a setting of seizure and moderate pallor. She had a significant past history of childbirth complicated with post-partum haemorrhage after which she developed secondary amenorrhoea and lactation failure. Workup showed suppressed levels of all pituitary hormones and was treated as myxoedemic coma. A diagnosis of Sheehan and #8217;s syndrome presenting as myxoedemic coma - a rare but emergency presentation was made. [Int J Res Med Sci 2014; 2(3.000: 1151-1153

  13. Emergency Neurological Life Support: Approach to the Patient with Coma.

    Science.gov (United States)

    Stevens, Robert D; Cadena, Rhonda S; Pineda, Jose

    2015-12-01

    Coma is an acute failure of neuronal systems governing arousal and awareness and represents a medical emergency. When encountering a comatose patient, the clinician must have an organized approach to detect easily remediable causes, prevent ongoing neurologic injury, and determine a hierarchical plan for diagnostic tests, treatments, and neuromonitoring. Coma was chosen as an Emergency Neurological Life Support protocol because timely medical and surgical interventions can be life-saving, and the initial work-up of such patients is critical to establishing a correct diagnosis.

  14. Spontaneous Intracranial Hypotension: An Etiology for Consciousness Disorder and Coma.

    Science.gov (United States)

    Collange, Olivier; Wolff, Valérie; Cebula, Hélène; Pradignac, Alain; Meyer, Alain; Kindo, Michel; Diemunsch, Pierre; Proust, François; Mertes, Paul-Michel; Kremer, Stéphane

    2016-11-15

    We report 3 cases of spontaneous intracranial hypotension (SIH) associated with consciousness disorder and coma. In patients, SIH was suspected on a computed tomography scan and diagnosed by cerebral magnetic resonance imaging (MRI). Spinal MRI confirmed cerebrospinal fluid leakage. SIH should be seen as an underestimated cause of consciousness disorder and coma, especially in patients with a history of orthostatic headache, spinal injury, or oculomotor signs. Computed tomography scans should be examined for signs of SIH before operating on patients with a spontaneous subdural hematoma. Brain and spine MRI should be performed when SIH is suspected. Our 3 patients have shown good recovery without any neurological sequelae.

  15. Coma from long-term overingestion of isoniazid.

    Science.gov (United States)

    Salkind, A R; Hewitt, C C

    1997-11-24

    Overingestion of isoniazid can cause confusion, slurred speech, seizures, coma, and death. Most cases of a central nervous system toxic reaction due to isoniazid use result from sudden intentional or accidental overdose. We describe a patient taking 1200 mg of isoniazid daily for 6 weeks who presented to the hospital with confusion and lethargy that progressed to coma. Within 30 minutes of receiving 1 g of intravenous pyridoxine hydrochloride, the patient was fully alert and lucid. The diagnosis of a toxic reaction to isoniazid was delayed by the possibility of concurrent active neurosyphilis and the failure to initially consider isoniazid poisoning in a patient without a history of sudden isoniazid overdose.

  16. Synthesis and Evaluation of Changes Induced by Solvent and Substituent in Electronic Absorption Spectra of New Azo Disperse Dyes Containig Barbiturate Ring

    OpenAIRE

    2013-01-01

    Six azo disperse dyes were prepared by diazotizing 4-amino hippuric acid and coupled with barbituric acid and 2-thiobarbituric acid. Then, the products were reacted with aromatic aldehyde, sodium acetate, and acetic anhydride, and oxazolone derivatives were formed. Characterization of the dyes was carried out by using UV-Vis, FT-IR, 1H NMR and 13C NMR, and mass spectroscopic techniques. The solvatochromic behavior of azo disperse dyes was evaluated in various solvents. The effects of substitu...

  17. Knoevenagel condensation of α,β-unsaturated aromatic aldehydes with barbituric acid under non-catalytic and solvent-free conditions

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    An efficient route for the synthesis of 5-(arylpropenylidine)-2,4,6-pyrimidinetrione 3 from an appropriate α,β-unsaturated aromatic aldehydes 1 and barbituric acid 2 under both non-catalytic and solvent-free microwave irradiation conditions was described. In this way, a range of biologically important compounds 3 was obtained in good to excellent yields (86-98 %) in a very short reaction time (30-80 s).

  18. Predicting outcome from coma : man-in-the-barrel syndrome as potential pitfall

    NARCIS (Netherlands)

    Elting, JW; Haaxma, R; De Keyser, J; Sulter, G.

    2000-01-01

    The Glasgow coma scale motor score is often used in predicting outcome after hypoxic ischemic coma. Judicious care should be exerted when using this variable in predicting outcome in patients with coma following hypotension since borderzone infarction can obscure the clinical picture. We describe a

  19. Gait and Glasgow Coma Scale scores can predict functional recovery in patients with traumatic brain injury

    Institute of Scientific and Technical Information of China (English)

    Sevil Bilgin; Arzu Guclu-Gunduz; Hakan Oruckaptan; Nezire Kose; Bülent Celik

    2012-01-01

    Fifty-one patients with mild (n = 14), moderate (n = 10) and severe traumatic brain injury (n = 27)received early rehabilitation. Level of consciousness was evaluated using the Glasgow Coma Score. Functional level was determined using the Glasgow Outcome Score, whilst mobility was evaluated using the Mobility Scale for Acute Stroke. Activities of daily living were assessed using the Barthel Index. Following Bobath neurodevelopmental therapy, the level of consciousness was significantly improved in patients with moderate and severe traumatic brain injury, but was not greatly influenced in patients with mild traumatic brain injury. Mobility and functional level were significantly improved in patients with mild, moderate and severe traumatic brain injury. Gait recovery was more obvious in patients with mild traumatic brain injury than in patients with moderate and severe traumatic brain injury. Activities of daily living showed an improvement but this was insignificant except for patients with severe traumatic brain injury. Nevertheless, complete recovery was not acquired at discharge. Multiple regression analysis showed that gait and Glasgow Coma Scale scores can be considered predictors of functional outcomes following traumatic brain injury.

  20. [Prognosis of intracerebral hemorrhage with coma in a neurological critical care unit in the tropics].

    Science.gov (United States)

    Sène Diouf, F; Mapoure, N Y; Ndiaye, M; Mbatchou Ngahane, H B; Touré, K; Thiam, A; Mboup, B; Doumbe, J N; Diop, A G; Ndiaye, M M; Ndiaye, I P

    2008-12-01

    Thirty-five percent of stroke events observed in Dakar, Senegal involve hemorrhaging. Coma is a frequent revealing sign of the disease and a severe prognostic factor. Since specific therapy is unavailable in sub-Saharan Africa, only symptomatic medical treatment is proposed to most patients presenting intracerebral hemorrhage. The purpose of this longitudinal study was to evaluate prognosis and survival in patients presenting with intracerebral hemorrhage in a neurological critical care unit in Senegal. Study was conducted from April 15, 2006 to July 18, 2007 in the neurological critical unit of the Fann University Hospital Center in Dakar. Mortality and probability of survival were estimated using Kaplan Meier methods. The predictive value of factors significantly correlated with prognosis was determined by multivariate analysis using a Cox proportional hazards model. A total of 51 cases of intracerebral hemorrhage were included in this study. Mean patient age was 64 years and the sex ratio was 1.13. Median survival was 7 days and mortality in the neurological critical care unit was 80.4%. The probability of survival at days 10, 30 and 90 were 43.14%, 21.57% and 13.73% respectively. Occurrence of a complication on day 3 was shown to be an independent risk factor for early death. Intracerebral hemorrhage with coma is associated with a high mortality rate. Better primary prevention is necessary.

  1. Nucleated Dwarf Elliptical Galaxies in the Coma Cluster

    NARCIS (Netherlands)

    Matkovic, Ana; Ferguson, H. C.; Peng, E.; den Brok, M.

    2010-01-01

    Recent studies show that most dwarf elliptical galaxies (dE) in nearby clusters possess nuclear star clusters. Earlier studies used photographic plates and frequently missed the faint nuclei in dEs. For the first time, we are able to identify nuclei in a large number of dE galaxies in the Coma clust

  2. Complete recovery after severe myxoedema coma complicated by status epilepticus

    DEFF Research Database (Denmark)

    Fjølner, Jesper; Opstrup, Ulla Kampmann; Søndergaard, Esben;

    2015-01-01

    We report a case of life-threatening myxoedema presenting with hypothermia, hypotension, bradycardia, pericardial effusion and deep coma. The condition was complicated by prolonged status epilepticus. The optimal treatment strategy has been debated over the years and the literature is briefly...

  3. A preliminary model of the coma of 2060 Chiron

    Science.gov (United States)

    Boice, Daniel C.; Konno, I.; Stern, S. Alan; Huebner, Walter F.

    1992-01-01

    We have included gravity in our fluid dynamic model with chemical kinetics of dusty comet comae and applied it with two dust sizes to 2060 Chiron. A progress report on the model and preliminary results concerning gas/dust dynamics and chemistry is given.

  4. Analysis on care outcome of patients with polytrauma and coma

    Institute of Scientific and Technical Information of China (English)

    ZHAO Xing-ji; KONG Ling-wen; DU Ding-yuan; SU Hong-jie

    2007-01-01

    Objective:To make further improvement of outcome of patients with polytrauma and coma. Methods:The data of 3 361 patients (2 378 males and 983 females,aged from 5-95 years,38.2 years on average) with severe polytrauma and coma admitted to Chongqing Emergency Medical Center (Level I Trauma Center), Chongqing,China, from November 1978 to December 2004 were analyzed retrospectively in this study.Results:The overall survival rate and mortality were 93.2 % (3 133/3 361 ) and 6.8 % ( 228/3 361 ),respectively.The mortalities in patients with coma duration < 1 hour and combined with neural dysfunction and in patients with coma duration ≥ 1 hour and combined with or without neural dysfunction were significantly higher than that of those with coma duration < 1 hour but without neural dysfunction[39.5 % (136/344) vs 3.0 % ( 92/3 017 ),P < 0.01 ].There existed significant differences in GCS,ISS,and revised trauma score (RTS) between the death group and the survival group (P <0.01). RTS was in good correspondence with patient's pathophysiological status and outcome in patients with multiple trauma and coma for different groups of systolic blood pressure (SBP).The mortality in patients with SBP < 90 mm Hg was significantly higher than that of those with SBP ≥ 90 mm Hg [33.3 %(68/204) vs 5.1%(160/3 157),P <0.01].The mortality in polytrauma patients combined with serious head injury (AIS≥3) was 8.2%,among which,76.5% died from lung complications.The morbidity rate of lung complications and mortality rate increased in patients with head injury complicated with chest or abdomen injury (23.9 %,61.1%vs 27.3%,50.0%).The mortality reached up to 61.9% in patients complicated with severe head,chest and abdomen injuries simultaneously. Conclusions:It plays a key role to establish a fast and effective trauma care system and prompt and definite surgical procedures and to strengthen the management of complications for improving the survival rate of patients with severe

  5. A rapid murine coma and behavior scale for quantitative assessment of murine cerebral malaria.

    Directory of Open Access Journals (Sweden)

    Ryan W Carroll

    Full Text Available BACKGROUND: Cerebral malaria (CM is a neurological syndrome that includes coma and seizures following malaria parasite infection. The pathophysiology is not fully understood and cannot be accounted for by infection alone: patients still succumb to CM, even if the underlying parasite infection has resolved. To that effect, there is no known adjuvant therapy for CM. Current murine CM (MCM models do not allow for rapid clinical identification of affected animals following infection. An animal model that more closely mimics the clinical features of human CM would be helpful in elucidating potential mechanisms of disease pathogenesis and evaluating new adjuvant therapies. METHODOLOGY/PRINCIPAL FINDINGS: A quantitative, rapid murine coma and behavior scale (RMCBS comprised of 10 parameters was developed to assess MCM manifested in C57BL/6 mice infected with Plasmodium berghei ANKA (PbA. Using this method a single mouse can be completely assessed within 3 minutes. The RMCBS enables the operator to follow the evolution of the clinical syndrome, validated here by correlations with intracerebral hemorrhages. It provides a tool by which subjects can be identified as symptomatic prior to the initiation of trial treatment. CONCLUSIONS/SIGNIFICANCE: Since the RMCBS enables an operator to rapidly follow the course of disease, label a subject as affected or not, and correlate the level of illness with neuropathologic injury, it can ultimately be used to guide the initiation of treatment after the onset of cerebral disease (thus emulating the situation in the field. The RMCBS is a tool by which an adjuvant therapy can be objectively assessed.

  6. Predicting Early Awakening from Coma after Intracerebral Hemorrhage

    Directory of Open Access Journals (Sweden)

    Diana eGoodman

    2013-10-01

    Full Text Available Introduction – Given the high morbidity and mortality associated with intracerebral hemorrhage (ICH, family members and healthcare providers base early supportive management decisions, at least in part, on expected prognosis. In the comatose patient with ICH, this short-term prognosis is most overtly characterized by regaining of consciousness.Methods – A retrospective consecutive cohort of 51 patients admitted to a neuroICU with ICH and admission Glasgow Coma Scale score ≤ 8 was identified. Logistic regression was performed to assess the association of baseline characteristics and treatment parameters associated with awakening.Results – Awakening from coma was observed in 53% of ICH patients: 83% with an initial GCS score of 7-8, 43% with an initial score of 5-6, and 20% with an initial score of 3-4. Awakening from coma in the cohort of 27 patients who regained consciousness occurred in 59% of patients by day 2, 89% by day 7, and 96% by day 9. In multivariable analysis, only higher admission GCS score was associated with a greater likelihood of awakening from coma (OR 4.9 [95%CI 1.9–13] per 2-point category, p=0.001. DNR status during the first 24 hours was not associated with awakening but was at later time points.Conclusion – GCS score is the predominant initial predictor of early awakening in patients who present in coma after ICH. Patients who regained consciousness typically did so within the first 9 days of hospital admission.

  7. Effect of Coma Aberration on Orbital Angular Momentum Spectrum of Vortex Beams

    Institute of Scientific and Technical Information of China (English)

    CHEN Zi-Yang; PU Ji-Xiong

    2009-01-01

    Spiral spectra of vortex beams with coma aberration are studied.It is shown that the orbital angular momentum (OAM) states of vortex beams with coma aberration are different from those aberration-free vortex beams.Spiral spectra of beams with coma aberration are spreading.It is found that in the presence of coma aberration,the vortex beams contain not only the original OAM component but also other components.A larger coma aberration coefficient and/or a larger beam waist will lead to a wider spreading of the spiral spectrum. The results may have potential applications in information encoding and transmittance.

  8. Full Outline of Unresponsiveness score and the Glasgow Coma Scale in prediction of pediatric coma

    Science.gov (United States)

    Jamal, Atahar; Sankhyan, Naveen; Jayashree, Murlidharan; Singhi, Sunit; Singhi, Pratibha

    2017-01-01

    BACKGROUND: This study was done to compare the admission Full Outline of Unresponsiveness (FOUR) score and Glasgow Coma Scale (GCS) as predictors of outcome in children with impaired consciousness. METHODS: In this observational study, children (5–12 years) with impaired consciousness of Pediatric Overall Performance Category Scale at 3 months. RESULTS: Of the 63 children, 20 died during hospital stay. AUC for in-hospital mortality for GCS was 0.83 (CI 0.7 to 0.9) and FOUR score was 0.8 (CI 0.7 to 0.9) [difference between areas –0.0250 (95%CI 0.0192 to 0.0692), Z statistic 1.109, P=0.2674]. AUC for mortality at 3 months for GCS was 0.78 (CI 0.67 to 0.90) and FOUR score was 0.74 (CI 0.62 to 0.87) (P=0.1102) and AUC for poor functional outcome for GCS was 0.82 (CI 0.72 to 0.93) and FOUR score was 0.79 (CI 0.68 to 0.9) (P=0.2377), which were also comparable. Inter-rater reliability for GCS was 0.96 and for FOUR score 0.98. CONCLUSION: FOUR score was as good as GCS in prediction of in-hospital and 3-month mortality and functional outcome at 3 months. FOUR score had a good inter-rater reliability. PMID:28123622

  9. [Irreversible coma following hypoglycemia in Sheehan syndrome with adrenocortical insufficiency].

    Science.gov (United States)

    Sas, A M; Meynaar, I A; Laven, J S; Bakker, S L; Feelders, R A

    2003-08-23

    A 24-year-old woman of Somali origin delivered at term after an uncomplicated pregnancy. Post-partum haemorrhage resulted in hypovolaemic shock which was treated by hysterectomy. Five days later she became comatose due to unrecognised hypoglycaemia which caused severe irreversible brain damage and status epilepticus. Treatment in the intensive care unit with artificial respiration, prednisolone, desmopressin, inotropic support, barbiturates and an anaesthetic under EEG guidance was unsuccessful. The patient died 28 days post-partum. The hypoglycaemia was due to a combination of (a) inadequate glucose intake and (b) lack of counter-regulatory mechanisms due to a deficiency of steroids and growth hormone as a result of loss of pituitary function (Sheehan syndrome) together with adrenocortical insufficiency. The combination of Sheehan syndrome and primary adrenocortical insufficiency has not been described previously in the literature.

  10. Results from a Second RXTE Observation of the Coma Cluster

    CERN Document Server

    Rephaeli, Y; Rephaeli, Yoel; Gruber, Duane

    2002-01-01

    The RXTE satellite observed the Coma cluster for 177 ksec during November and December 2000, a second observation motivated by the intriguing results from the first 87 ksec observation in 1996. Analysis of the new dataset confirms that thermal emission from isothermal gas does not provide a good fit to the spectral distribution of the emission from the inner 1 degree radial region. While the observed spectrum may be fit by emission from gas with a substantial temperature gradient, it is more likely that the emission includes also a secondary non-thermal component. If so, non-thermal emission comprises ~8% of the total 4--20 keV flux. Interpreting this emission as due to Compton scattering of relativistic electrons (which produce the known extended radio emission) by the cosmic microwave background radiation, we determine that the mean, volume-averaged magnetic field in the central region of Coma is B = 0.1-0.3 microgauss.

  11. [Multimodal neuromonitoring for the critical care management of acute coma].

    Science.gov (United States)

    Ltaief, Z; Ben-Hamouda, N; Suys, T; Daniel, R T; Rossetti, A O; Oddo, M

    2014-12-10

    Management of neurocritical care patients is focused on the prevention and treatment of secondary brain injury, i.e. the number of pathophysiological intracerebral (edema, ischemia, energy dysfunction, seizures) and systemic (hyperthermia, disorders of glucose homeostasis) events that occur following the initial insult (stroke, hemorrhage, head trauma, brain anoxia) that may aggravate patient outcome. The current therapeutic paradigm is based on multimodal neuromonitoring, including invasive (intracranial pressure, brain oxygen, cerebral microdialysis) and non-invasive (transcranial doppler, near-infrared spectroscopy, EEG) tools that allows targeted individualized management of acute coma in the early phase. The aim of this review is to describe the utility of multimodal neuromonitoring for the critical care management of acute coma.

  12. Revisiting the eye opening response of the Glasgow Coma Scale

    Directory of Open Access Journals (Sweden)

    Taopheeq Bamidele Rabiu

    2011-01-01

    Full Text Available The Glasgow Coma Scale (GCS, introduced by Teasdale and Jenneth in 1974, has received tremendous acclaim from clinicians and has been extensively used in clinical practice for the evaluation of the level of consciousness. The author notes that some traumatic brain injury patients close eyes in response to painful stimuli as opposed to the eye opening response to pain of the GCS. A revision of the eye opening response subsection of the GCS is suggested.

  13. Detection of Intracluster Planetary Nebulae in the Coma Cluster

    CERN Document Server

    Gerhard, O; Freeman, K C; Kashikawa, N; Okamura, S; Yasuda, N; Gerhard, Ortwin; Arnaboldi, Magda; Freeman, Kenneth C.; Kashikawa, Nobunari; Okamura, Sadanori; Yasuda, Naoki

    2005-01-01

    [OIII] lambda 5007AA emission lines of 16 intracluster planetary nebulae candidates in the Coma cluster were detected with a Multi-Slit Imaging Spectroscopy (MSIS) technique using FOCAS on the Subaru telescope. The identification of these faint emission sources as PNe is supported by (i) their point-like flux distribution in both space and wavelength, with tight limits on the continuum flux; (ii) the identification of the second [OIII] lambda 4959 line in the only object at high enough velocity that this line too falls into the filter bandpass; (iii) emission line fluxes consistent with PNe at 100 Mpc distance, in the range 2.8 x 10^{-19} - 1.7 x 10^{-18} erg/s/cm^2; and (iv) a narrow velocity distribution approximately centered on the systemic velocity of the Coma cluster. Comparing with the velocities of galaxies in our field, we conclude that the great majority of these candidates would be intracluster PNe, free floating in the Coma cluster core. Their velocity dispersion is ~760 km/s, and their mean veloc...

  14. Truncation of the krebs cycle during hypoglycemic coma.

    Science.gov (United States)

    Sutherland, Garnette R; Tyson, Randy L; Auer, Roland N

    2008-07-01

    There is a misconception that hypoglycemic nerve cell death occurs easily, and can happen in the absence of coma. In fact, coma is the prerequisite for neuronal death, which occurs via metabolic excitatory amino acid release. The focus on nerve cell death does not explain how most brain neurons and all glia survive. Brain metabolism was interrogated in rats during and following recovery from 40 min of profound hypoglycemia using ex vivo (1)H MR spectroscopy to determine alterations accounting for survival of brain tissue. As previously shown, a time-dependent increase in aspartate was equaled by a reciprocal decrease in glutamate/glutamine. We here show that the kinetics of aspartate formation during the first 30 min (0.36 +/- 0.03 micromol g(-1) min(-1)) are altered such that glutamate, via aspartate aminotransferase, becomes the primary source of carbon when glucose-derived pyruvate is unavailable. Oxaloacetate is produced directly from alpha-ketoglutarate, so that reactions involving the six-carbon intermediates of the tricarboxylic acid cycle are bypassed. These fundamental observations in basic metabolic pathways in effect redraw the tricarboxylic acid cycle from a tricarboxylic to a dicarboxylic acid cycle during hypoglycemia. The basic neurochemical alterations according to the chemical equilibrium of mass action augments flux through a truncated Krebs cycle that continues to turn during hypoglycemic coma. This explains the partial preservation of energy charge and brain cell survival during periods of glucose deficiency.

  15. Clinical neurophysiology in acute coma and disorders of consciousness.

    Science.gov (United States)

    Koenig, Matthew A; Kaplan, Peter W

    2013-04-01

    Over the last decade, significant improvements have been made in understanding and categorizing coma and disorders of consciousness. Although imaging techniques have been paramount in exploring disorders of consciousness, electrophysiologic techniques continue to be important for studying brain function in behaviorally unresponsive patients. In acute coma, electroencephalogram and evoked potentials have important roles in excluding nonconvulsive seizures, determining prognosis, monitoring for signs of improvement or worsening, and examining for markers of conscious response to external stimuli. Absence of cortical SSEPs is the most specific marker of poor prognosis after cardiac arrest. Recognition of stimulus-induced epileptiform discharges and clinical seizures has further blurred the lines along the ictal-interictal spectrum in coma. For chronic disorders of consciousness, more experimental techniques, such as cognitive event-related potentials and long-latency evoked potentials, have demonstrated an expanded role in determining prognosis and examining for indicators of consciousness. Like functional magnetic resonance imaging, these specialized techniques have demonstrated signs of preserved cognition in patients who otherwise appear unconscious. Future directions for clinical electrophysiologic testing in disorders of consciousness are likely to include automated and quantitative signal processing techniques and better standardization of cognitive event-related potentials.

  16. Coma and vegetative states: state of the art and proposal of a novel approach combining existing coma scales.

    Science.gov (United States)

    Bonsignore, Luca Tommaso; Macrì, Simone; Orsi, Paolo; Chiarotti, Flavia; Alleva, Enrico

    2014-01-01

    Brain damage of various aetiologies can lead to different disorders of consciousness (DOC), varying from coma to vegetative, to minimally conscious states. Each state is characterised by a different degree of wakefulness, awareness, pain sensitivity and is differentially handled with respect to treatment, ethical considerations and end-oflife decisions. Thus, its correct identification is crucial while devising or modulating appropriate treatment strategies. Actually, the main coma scales cannot always accurately determine the state of consciousness of an individual, while other tools (e.g. imaging techniques) present a certain degree of uncertainty. A complementary approach may be constituted by a 24-hour observation of patients, for a sufficient period of days, using an ad hoc behavioural scale, further correlated with physiological and pharmacological parameters measured on patients. The method herein described might help recognising the presence of consciousness of the different DOC patients, and thus discerning a vegetative from a minimally conscious state.

  17. Coma and vegetative states: state of the art and proposal of a novel approach combining existing coma scales

    Directory of Open Access Journals (Sweden)

    Luca Tommaso Bonsignore

    2014-09-01

    Full Text Available Brain damage of various aetiologies can lead to different disorders of consciousness (DOC, varying from coma to vegetative, to minimally conscious states. Each state is characterised by a different degree of wakefulness, awareness, pain sensitivity and is differentially handled with respect to treatment, ethical considerations and end-of-life decisions. Thus, its correct identification is crucial while devising or modulating appropriate treatment strategies. Actually, the main coma scales cannot always accurately determine the state of consciousness of an individual, while other tools (e.g. imaging techniques present a certain degree of uncertainty. A complementary approach may be constituted by a 24-hour observation of patients, for a sufficient period of days, using an ad hoc behavioural scale, further correlated with physiological and pharmacological parameters measured on patients. The method herein described might help recognising the presence of consciousness of the different DOC patients, and thus discerning a vegetative from a minimally conscious state.

  18. Molecular structure and spectroscopic investigations combined with hypoglycemic/anticancer and docking studies of a new barbituric acid derivative

    Science.gov (United States)

    Barakat, Assem; Soliman, Saied M.; Elshaier, Yaseen A. M. M.; Ali, M.; Al-Majid, Abdullah Mohammed; Ghabbour, Hazem A.

    2017-04-01

    The one-pot synthesis reaction of barbituric acid derivative, 1,3-cyclohexandione, and 4-fluorobenzaldehyde in water mediated by NHEt2 as base afforded 4 with excellent yield. The synthesized compound was characterized by spectrophotometric tools as well as X-ray single crystal diffraction technique. The stability of the nine possible isomers of the synthesized compound was studied using the B3LYP method and 6-31G(d,p) basis set. The electronic and spectroscopic properties of the most stable isomer were predicted. The UV-Vis absorption spectrum displayed two bands at 203 and 257 nm in the solvent chloroform. The latter was calculated at 235.6 nm (f = 0.1995) in the gas phase due to H-2→L (42%) and H-1→L+2 (14%) excitations. In solution, using chloroform as a solvent, a slight bathochromic shift to 237.6 nm with an increase in the absorption intensity (f = 0.2898) was predicted. The molecular orbital energy level diagram of this transition band was characterized mainly by π-π* transitions. The 13C and 1H NMR chemical shifts correlated well with the experimental data. The correlations had higher correlation coefficients (R2) when solvent effects were considered. The atomic charges were calculated using natural population analysis and the charged regions were presented using a molecular electrostatic potential (MEP) map. The synthesized compound was examined as a hypoglycemic agent via inhibition of α-glucosidase and β-glucuronidase enzymes. Its inhibitory activity against α-glucosidase was 10 times greater than the inhibitory activity of the standard drug acarbose (IC50 77.9 ± 0.3 μM and 840 ± 1.73 μM, respectively). Moreover, the target compound was evaluated for anticancer activity against MCF-7, H460, 3T3, and Hela cell lines. It demonstrated inhibitory activity against the MCF-7 and H460 cell lines with IC50 5.80 ± 0.12 and 19.6 ± 0.5 μM, respectively, in comparison to doxorubicin. The docking study was performed using the OpenEye program.

  19. A Rare Case of Myxedema Coma with Neuroleptic Malignant Syndrome (NMS).

    Science.gov (United States)

    Dixit, Siddharth; Dutta, Manoj Kumar; Namdeo, Mayank

    2015-05-01

    Myxedema coma or hypothyroid crisis is an endocrine emergency and needs ICU management. Neuroleptic malignant syndrome (NMS) is another medical emergency which needs high degree of clinical suspicion else mortality can be high. There is a paradox in co existence of myxedema coma and NMS. While one is hypometabolic state another is hypermetabolic state and both can be precipitated by antipsychotics use. Hypothermia and flaccidity commonly expected in myxedema coma may mask fever and rigidity of classical NMS contributing to diagnostic problem and treatment delay. Scientific literature on coexistance of myxedema coma and NMS is sparse. We hereby report first case with coexisting myxedema coma and NMS in a patient of schizophrenia treated with antipsychotic, where classical symptoms of NMS were masked by myxedema coma. Prompt diagnosis and effective management by a team resulted in favourable outcome in our patient. This case is reported to alert intensive care physicians to atypical manifestations of NMS in presence of hypothyroidism.

  20. 3D-QSAR Studies on Barbituric Acid Derivatives as Urease Inhibitors and the Effect of Charges on the Quality of a Model.

    Science.gov (United States)

    Ul-Haq, Zaheer; Ashraf, Sajda; Al-Majid, Abdullah Mohammed; Barakat, Assem

    2016-04-30

    Urease enzyme (EC 3.5.1.5) has been determined as a virulence factor in pathogenic microorganisms that are accountable for the development of different diseases in humans and animals. In continuance of our earlier study on the helicobacter pylori urease inhibition by barbituric acid derivatives, 3D-QSAR (three dimensional quantitative structural activity relationship) advance studies were performed by Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) methods. Different partial charges were calculated to examine their consequences on the predictive ability of the developed models. The finest developed model for CoMFA and CoMSIA were achieved by using MMFF94 charges. The developed CoMFA model gives significant results with cross-validation (q²) value of 0.597 and correlation coefficients (r²) of 0.897. Moreover, five different fields i.e., steric, electrostatic, and hydrophobic, H-bond acceptor and H-bond donors were used to produce a CoMSIA model, with q² and r² of 0.602 and 0.98, respectively. The generated models were further validated by using an external test set. Both models display good predictive power with r²pred ≥ 0.8. The analysis of obtained CoMFA and CoMSIA contour maps provided detailed insight for the promising modification of the barbituric acid derivatives with an enhanced biological activity.

  1. 3D-QSAR Studies on Barbituric Acid Derivatives as Urease Inhibitors and the Effect of Charges on the Quality of a Model

    Directory of Open Access Journals (Sweden)

    Zaheer Ul-Haq

    2016-04-01

    Full Text Available Urease enzyme (EC 3.5.1.5 has been determined as a virulence factor in pathogenic microorganisms that are accountable for the development of different diseases in humans and animals. In continuance of our earlier study on the helicobacter pylori urease inhibition by barbituric acid derivatives, 3D-QSAR (three dimensional quantitative structural activity relationship advance studies were performed by Comparative Molecular Field Analysis (CoMFA and Comparative Molecular Similarity Indices Analysis (CoMSIA methods. Different partial charges were calculated to examine their consequences on the predictive ability of the developed models. The finest developed model for CoMFA and CoMSIA were achieved by using MMFF94 charges. The developed CoMFA model gives significant results with cross-validation (q2 value of 0.597 and correlation coefficients (r2 of 0.897. Moreover, five different fields i.e., steric, electrostatic, and hydrophobic, H-bond acceptor and H-bond donors were used to produce a CoMSIA model, with q2 and r2 of 0.602 and 0.98, respectively. The generated models were further validated by using an external test set. Both models display good predictive power with r2pred ≥ 0.8. The analysis of obtained CoMFA and CoMSIA contour maps provided detailed insight for the promising modification of the barbituric acid derivatives with an enhanced biological activity.

  2. Daily isoflurane exposure increases barbiturate insensitivity in medullary respiratory and cortical neurons via expression of ε-subunit containing GABA ARs.

    Directory of Open Access Journals (Sweden)

    Keith B Hengen

    Full Text Available The parameters governing GABAA receptor subtype expression patterns are not well understood, although significant shifts in subunit expression may support key physiological events. For example, the respiratory control network in pregnant rats becomes relatively insensitive to barbiturates due to increased expression of ε-subunit-containing GABAARs in the ventral respiratory column. We hypothesized that this plasticity may be a compensatory response to a chronic increase in inhibitory tone caused by increased central neurosteroid levels. Thus, we tested whether increased inhibitory tone was sufficient to induce ε-subunit upregulation on respiratory and cortical neurons in adult rats. Chronic intermittent increases in inhibitory tone in male and female rats was induced via daily 5-min exposures to 3% isoflurane. After 7d of treatment, phrenic burst frequency was less sensitive to barbiturate in isoflurane-treated male and female rats in vivo. Neurons in the ventral respiratory group and cortex were less sensitive to pentobarbital in vitro following 7d and 30d of intermittent isoflurane-exposure in both male and female rats. The pentobarbital insensitivity in 7d isoflurane-treated rats was reversible after another 7d. We hypothesize that increased inhibitory tone in the respiratory control network and cortex causes a compensatory increase in ε-subunit-containing GABAARs.

  3. The Hubble Space Telescope advanced camera for surveys coma cluster survey. I. Survey objectives and design

    NARCIS (Netherlands)

    Carter, David; Goudfrooij, Paul; Mobasher, Bahram; Ferguson, Henry C.; Puzia, Thomas H.; Aguerri, Alfonso L.; Balcells, Marc; Batcheldor, Dan; Bridges, Terry J.; Davies, Jonathan I.; Erwin, Peter; Graham, Alister W.; Guzmán, Rafael; Hammer, Derek; Hornschemeier, Ann; Hoyos, Carlos; Hudson, Michael J.; Huxor, Avon; Jogee, Shardha; Komiyama, Yutaka; Lotz, Jennifer; Lucey, John R.; Marzke, Ronald O.; Merritt, David; Miller, Bryan W.; Miller, Neal A.; Mouhcine, Mustapha; Okamura, Sadanori; Peletier, Reynier F.; Phillipps, Steven; Poggianti, Bianca M.; Sharples, Ray M.; Smith, Russell J.; Trentham, Neil; Tully, R. Brent; Valentijn, Edwin; Verdoes Kleijn, Gijs

    2008-01-01

    We describe the HST ACS Coma Cluster Treasury survey, a deep two-passband imaging survey of one of the nearest rich clusters of galaxies, the Coma Cluster (Abell 1656). The survey was designed to cover an area of 740 arcmin2 in regions of different density of both galaxies and intergalactic medium w

  4. Detection of a virial shock around the Coma galaxy cluster

    CERN Document Server

    Keshet, Uri; Loeb, Abraham; Waxman, Eli

    2012-01-01

    Galaxy clusters, the largest gravitationally bound objects in the Universe, are thought to grow by accreting mass from their surroundings through large-scale virial shocks. Due to electron acceleration in such a shock, it should appear as a gamma-ray, hard X-ray, and radio ring, elongated towards the large-scale filaments feeding the cluster, coincident with a cutoff in the thermal Sunyaev-Zel'dovich (SZ) signal. However, no such signature was found so far, and the very existence of cluster virial shocks has remained a theory. We report the discovery of a large, ~5 Mpc diameter gamma-ray ring around the Coma cluster, elongated towards the large scale filament connecting Coma and Abell 1367. The gamma-ray ring correlates both with a synchrotron signal and with the SZ cutoff. The gamma-ray, hard-X-ray, and radio signatures agree with analytic and numerical predictions, if the shock deposits a few percent of the thermal energy in relativistic electrons over a Hubble time, and ~1% of the energy in magnetic fields...

  5. X-ray archaeology in the Coma cluster

    Science.gov (United States)

    White, Simon D. M.; Briel, Ulrich G.; Henry, J. P.

    1993-01-01

    We present images of X-ray emission from hot gas within the Coma cluster of galaxies. These maps, made with the ROSAT satellite, have much higher SNR than any previous X-ray image of a galaxy cluster, and allow cluster structure to be analyzed in unprecedented detail. They show greater structural irregularity than might have been anticipated from earlier observations of Coma. Emission is detected from a number of bright cluster galaxies in addition to the two known previously. In four cases, there is evidence that these galaxies lie at the center of an extended subconcentration within the cluster, possibly the remnant of their associated groups. For at least two galaxies, the images show direct evidence for ongoing disruption of their gaseous atmosphere. The luminosity associated with these galaxies is comparable to that detected around similar ellipticals in much poorer environments. Emission is easily detected to the limit of our field, about 1 deg from the cluster center, and appears to become more regular at large radii. The data show clearly that this archetype of a rich and regular galaxy cluster was, in fact, formed by the merging of several distinct subunits which are not yet fully destroyed.

  6. Breaking the mass / anisotropy degeneracy in the Coma cluster

    CERN Document Server

    Mamon, G A; Sanchis, T

    2004-01-01

    We provide the first direct lifting of the mass/anisotropy degeneracy for a cluster of galaxies, by jointly fitting the line of sight velocity dispersion and kurtosis profiles of the Coma cluster, assuming an NFW tracer density profile, a generalized-NFW dark matter profile and a constant anisotropy profile. We find that the orbits in Coma must be quasi-isotropic, and find a mass consistent with previous analyses, but a concentration parameter 50% higher than expected in cosmological N-body simulations. We then test the accuracy of our method on realistic non-spherical systems with substructure and streaming motions, by applying it to the ten most massive structures in a cosmological N-body simulation. We find that our method yields fairly accurate results on average (within 20%), although with a wide variation (factor 1.7 at 1 sigma) for the concentration parameter, with decreased accuracy and efficiency when the projected mean velocity is not constant with radius.

  7. Substructure in the Coma Cluster Giants vs Dwarfs

    CERN Document Server

    Edwards, S A; Bridges, T J; Carter, D; Mobasher, B; Poggianti, B M; Edwards, Scott A.; Colless, Matthew; Bridges, Terry J.; Carter, Dave; Mobasher, Bahram; Poggianti, Bianca M.

    2001-01-01

    The processes that form and shape galaxy clusters, such as infall, mergers and dynamical relaxation, tend to generate distinguishable differences between the distributions of a cluster's giant and dwarf galaxies. Thus the dynamics of dwarf galaxies in a cluster can provide valuable insights into its dynamical history. With this in mind, we look for differences between the spatial and velocity distributions of giant (b18) galaxies in the Coma cluster. Our redshift sample contains new measurements from the 2dF and WYFFOS spectrographs, making it more complete at faint magnitudes than any previously studied sample of Coma galaxies. It includes 745 cluster members - 452 giants and 293 dwarfs. We find that the line-of-sight velocity distribution of the giants is significantly non-Gaussian, but not that for the dwarfs. A battery of statistical tests of both the spatial and localised velocity distributions of the galaxies in our sample finds no strong evidence for differences between the giant and dwarf populations....

  8. {sup 1} H and {sup 13} C NMR studies on the enoling of 5-benzyl barbituric acids; Estudos por H-1 e C-13 RMN da enolizacao de acidos 5-benzil barbituricos

    Energy Technology Data Exchange (ETDEWEB)

    Villar, Jose Daniel Figueroa; Santos, Nedina Lucia dos; Cruz, Elizabete Rangel [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil). Secao de Quimica

    1991-12-31

    This work shows that the derivatives of the 5-benzyl barbituric acids hydroxylated at the ortho position of the aromatic ring only exist in the enol form. and that the alkylation of this hydroxyl gives products which exist mainly in the ketone form of the DMSO 5 refs., 2 figs., 2 tabs.

  9. Image Enhancement Techniques for Quantitative Investigations of Morphological Features in Cometary Comae: A Comparative Study

    CERN Document Server

    Samarasinha, Nalin

    2014-01-01

    Many cometary coma features are only a few percent above the ambient coma (i.e., the background) and therefore coma enhancement techniques are needed to discern the morphological structures present in cometary comae. A range of image enhancement techniques widely used by cometary scientists is discussed by categorizing them and carrying out a comparative analysis. The enhancement techniques and the corresponding characteristics are described in detail and the respective mathematical representations are provided. As the comparative analyses presented in this paper make use of simulated images with known coma features, the feature identifications as well as the artifacts caused by enhancement provide an objective and definitive assessment of the various techniques. Examples are provided which highlight contrasting capabilities of different techniques to pick out qualitatively distinct features of widely different strengths and spatial scales. On account of this as well as serious image artifacts and spurious fe...

  10. SUZAKU OBSERVATIONS OF SUBHALOS IN THE COMA CLUSTER

    Energy Technology Data Exchange (ETDEWEB)

    Sasaki, Toru; Matsushita, Kyoko; Sato, Kosuke [Department of Physics, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601 (Japan); Okabe, Nobuhiro, E-mail: j1213703@ed.tus.ac.jp, E-mail: matusita@rs.kagu.tus.ac.jp [Department of Physical Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526 (Japan)

    2015-06-10

    We observed three massive subhalos in the Coma cluster with Suzaku. These subhalos, labeled “ID 1,” “ID 2,” and “ID 32,” were detected with a weak-lensing survey using Subaru/Suprime-Cam, and are located at the projected distances of 1.4 r{sub 500}, 1.2 r{sub 500}, and 1.6 r{sub 500} from the center of the Coma cluster, respectively. The subhalo “ID 1” has a compact X-ray excess emission close to the center of the weak-lensing mass contour, and the gas mass to weak-lensing mass ratio is about 0.001. The temperature of the emission is about 3 keV, which is slightly lower than that of the surrounding intracluster medium (ICM) and that expected for the temperature versus mass relation of clusters of galaxies. The subhalo “ID 32” shows an excess emission whose peak is shifted toward the opposite direction from the center of the Coma cluster. The gas mass to weak-lensing mass ratio is also about 0.001, which is significantly smaller than regular galaxy groups. The temperature of the excess is about 0.5 keV and significantly lower than that of the surrounding ICM and far from the temperature versus mass relation of clusters. However, there is no significant excess X-ray emission in the “ID 2” subhalo. Assuming an infall velocity of about 2000 km s{sup −1}, at the border of the excess X-ray emission, the ram pressures for “ID 1” and “ID 32” are comparable to the gravitational restoring force per area. We also studied the effect of the Kelvin–Helmholtz instability to strip the gas. Although we found X-ray clumps associated with the weak-lensing subhalos, their X-ray luminosities are much lower than the total ICM luminosity in the cluster outskirts.

  11. Distribucion de Hidrogeno Neutro EN Galaxias Espirales de Coma

    Science.gov (United States)

    Bravo-Alfaro, H.; van Gorkom, J. H.; Balkowski, C.; Cayatte, V.

    1998-11-01

    We have carried out a study of environmental effects on the properties and evolution of galaxies in clusters. We have studied the HI content of spiral galaxies in two nearby clusters, Abell~262 and Abell~1656 (Coma), from 21cm observations obtained with the Westerbork Synthesis Radio Telescope and with the Very Large Array. These observations have provided us the HI images of a sample of 11 galaxies in Abell~262, and 19 in Coma. We have computed the HI content and analyzed the HI distribution of detected galaxies, what enabled us to study the environmental effects on cluster galaxies, as well as the possible involved physical mechanisms. We confirm the tendency of HI deficient galaxies to be closer to the cluster core. We also estimate in a quantitative fashion the role that ram pressure stripping can play in the central cluster region, where the intra--cluster medium shows its most hostile density and temperature conditions. Most of galaxies showing a perturbed neutral hydrogen distribution are likely affected by ram pressure. Five star--bursting galaxies and one post--starburst were detected among the 19 HI detected objects in Coma. We conclude, from the analysis of their HI distribution and from the correlations of their positions in the cluster and U--V colors with the HI deficiency, that some cluster galaxies may follow an evolutionary sequence: galaxies would first become blue because of the interaction with the ICM, what trigger a burst of star--formation. Galaxies appear at this stage as HI deficient. The next step in this sequence would be the PSB stage, where galaxies arrive once they quench most of their HI reservoir and the star--formation stops in a short time-scale. The deep neutral gas stripping explain why these galaxies are hardly detected in HI. None of the closest galaxies to NGC~4839 have been detected in our observations around the Southwest group, what hints a previous passage across the cluster core with the consequence of a stripping process

  12. Coma Etiologies And Its One-Month Outcome Sina Hospital (Year 2000

    Directory of Open Access Journals (Sweden)

    Togha M

    2002-09-01

    Full Text Available Defining the patient outcome and decision making about allocation of our limited fund and technology for comatose patients depends on our knowledge about frequency and outcome of various coma etiologies. We determined the various coma causes frequency and one-month outcome of non traumatic coma. . In addition the co existence of the primary neurologic signs with the one-month outcome of non traumatic coma was defined."nMethods and Materials: Our study is based on 130 comatose patients in a one-year study in Sina Hospital that consisted of 80 non traumatic and 50 traumatic patients."nResults: 74% of the cases were men and 26% were women. The most common etiology of coma was trauma (38.5%. The other common etiologies were cerebro¬vascular diseases (25.4%, cancer (10% and hypoxia-ischemia (8.5%. The most common cause of coma in men was trauma (46.9% while the vascular diseases were the most common etiology of coma in women (41.2%.In under 40 year patients trauma was the cause of coma in 57.5% of cases in respect to 28% in above 40 cases. On the other hand, vascular diseases and malignancies were the etiology of coma in 15% of under 40 year patients and 46.5% of above 40 year patients. Among traumatic etiologies of coma, subdural hematoma was the most frequent (40%. In our research none of patients who did not have one of pupillary, oculocephalic or motor reflexes in the 3rd and 7th day of the onset of coma had acceptable outcome after one month. With consideration of pupillary, corneal, oculocephalic and motor reflexes in combination, loss of at least two of them in the 3rd and 7th day accompanied with no acceptable outcome. On the other hand the presence of three or more reflexes in the 3rd and 7th day of coma was a good prognostic factor, with 80% and 88.9% chance of acceptable recovery respectively."nConclusion: According of the study, the best time for prediction of outcome in a comatose patient, is the third or seventh the day after the onset

  13. MYXEDEMA COMA – A CAUSE FOR DELAYED RECOVERY FROM ANAESTHESIA

    Directory of Open Access Journals (Sweden)

    Shailaja

    2013-01-01

    Full Text Available ABSTRACT: Delayed recovery from anaesthesia poses a challenge to the anaesthesiologists. We report a case of 45-year-old lady, a known diabetic on oral hypoglycaemics posted for buttress plating for fracture tibia. On patient’s request gene ral anaesthesia was administered. She was haemodynamically stable throughout the procedure. At the end of the procedure, patient was apnoeic and unresponsive. She was investigated thorou ghly and a diagnosis of severe hypothyroidism was made with low free T 4 and T 3 and high TSH levels. The patient was successfully resuscitated after treating with oral T 4 , gradual rewarming, and inotropic support. KEY WORDS: Diabetes mellitus, Myxedema coma, Recovery from ana esthesia

  14. A photometric catalogue of the Coma cluster core

    CERN Document Server

    Lobo, C; Durret, F; Gerbal, D; Lefèvre, O; Mazure, A; Slezak, E

    1996-01-01

    We have obtained a mosaic of CCD images of the Coma cluster in the V-band covering a region of approximately 0.4 degrees$^2$ around both central cluster galaxies NGC 4889 and NGC 4874. An additional frame of $\\sim$ 90 arcmin$^2$ was taken of the south-west region around NGC 4839. We derived a catalogue of 7023 galaxies and 4096 stars containing positions, central surface brightnesses and isophotal V$_{26.5}$ magnitudes. We estimate that data is complete up to V $_{26.5}\\sim$ 22.5 and the surface brightness limiting detection value is (available in electronic form alone), along with a detailed description of the steps concerning the data reduction and quality of the computed parameters.

  15. Environmental effects on the Coma cluster luminosity function

    CERN Document Server

    Lobo, C; Durret, F; Gerbal, D; Lefèvre, O; Mazure, A; Slezak, E

    1996-01-01

    Using our catalogue of V_{26.5} isophotal magnitudes for 6756 galaxies in a region covering 60~\\times~25~arcmin^2 in the center of the Coma cluster, plus 267 galaxies in a region of 9.7~\\times~9.4~arcmin^2 around NGC~4839, we derive the luminosity function in the magnitude range 13.5\\leq V_{26.5} < 21.0 (corresponding to the absolute magnitude range -22.24 < M_{V26.5} \\leq -14.74). The luminosity function for this region is well fitted by the combination of a gaussian in its bright part and of a steep Schechter function (of index \\alpha =-1.8) in its faint part. Luminosity functions derived for individual regions surrounding the brightest galaxies show less steep slopes, strongly suggesting the existence of environmental effects. The implications of such effects and galaxy formation scenarios are discussed.

  16. Reversal of prolonged isoniazid-induced coma by pyridoxine.

    Science.gov (United States)

    Brent, J; Vo, N; Kulig, K; Rumack, B H

    1990-08-01

    Isoniazid overdose is known to result in the rapid onset of seizures, metabolic acidosis, and prolonged obtundation. Pyridoxine has been reported to be effective in treating isoniazid-induced seizures. We report three cases of obtundation secondary to isoniazid overdose that was immediately reversed by intravenous pyridoxine. In two of these cases, status seizures were stopped by intravenous pyridoxine administration, but the patients remained comatose for prolonged periods. The comas were immediately reversed by the administration of additional pyridoxine. In the third case, the patient's lethargy was treated by intravenous pyridoxine on presentation and was followed by immediate awakening. Pyridoxine is effective in treating not only isoniazid-induced seizures, but also the mental status changes associated with this overdose. The dose required to induce awakening may be higher than that required to control seizures.

  17. [Prognosis for patients in a coma following cardiopulmonary resuscitation].

    Science.gov (United States)

    Horn, J; Zandbergen, E G J; Koelman, J H T M; Hijdra, A

    2008-02-09

    Most patients with post-anoxic coma after resuscitation have a poor prognosis. Reliable prediction of poor outcomes (death or vegetative state after 1 month; death, vegetative state or severe disability after at least 6 months) at an early stage is important for both family members and treating physicians. Poor outcome can be predicted with 100% reliability in the first 3 days after resuscitation in about 80% of patients using pupillary and corneal reflexes and motor response from the neurological examination, cortical responses from somatosensory evoked potentials and EEG. The predictive value of a status epilepticus or serum levels of neuron-specific enolase is uncertain at this time. In contrast to poor outcomes, good neurological recovery cannot be predicted reliably at this time.

  18. Phase synchronization in electroencephalographic recordings prognosticates outcome in paediatric coma.

    Directory of Open Access Journals (Sweden)

    Vera Nenadovic

    Full Text Available Brain injury from trauma, cardiac arrest or stroke is the most important cause of death and acquired disability in the paediatric population. Due to the lifetime impact of brain injury, there is a need for methods to stratify patient risk and ultimately predict outcome. Early prognosis is fundamental to the implementation of interventions to improve recovery, but no clinical model as yet exists. Healthy physiology is associated with a relative high variability of physiologic signals in organ systems. This was first evaluated in heart rate variability research. Brain variability can be quantified through electroencephalographic (EEG phase synchrony. We hypothesised that variability in brain signals from EEG recordings would correlate with patient outcome after brain injury. Lower variability in EEG phase synchronization, would be associated with poor patient prognosis. A retrospective study, spanning 10 years (2000-2010 analysed the scalp EEGs of children aged 1 month to 17 years in coma (Glasgow Coma Scale, GCS, <8 admitted to the paediatric critical care unit (PCCU following brain injury from TBI, cardiac arrest or stroke. Phase synchrony of the EEGs was evaluated using the Hilbert transform and the variability of the phase synchrony calculated. Outcome was evaluated using the 6 point Paediatric Performance Category Score (PCPC based on chart review at the time of hospital discharge. Outcome was dichotomized to good outcome (PCPC score 1 to 3 and poor outcome (PCPC score 4 to 6. Children who had a poor outcome following brain injury secondary to cardiac arrest, TBI or stroke, had a higher magnitude of synchrony (R index, a lower spatial complexity of the synchrony patterns and a lower temporal variability of the synchrony index values at 15 Hz when compared to those patients with a good outcome.

  19. Ram Pressure Stripping and Morphological Transformation in the Coma Cluster

    Science.gov (United States)

    Gregg, Michael; West, Michael

    2017-01-01

    The two largest spiral galaxies in the Coma cluster, NGC4911 and NGC4921, exhibit signs of being vigorously ram-pressure stripped by the hot intracluster medium. HST ACS and WFC3 images have revealed galactic scale shock fronts, giant "Pillars of Creation", rivulets of dust, and spatially coherent star formation in these grand design spirals. All evidence points to these galaxies being stressed by a global external source which can only be the hot intracluster medium (ICM). Inspired by these examples, we have obtained HST WFC3 imaging of five additional large spirals to search for and investigate the effects of ram pressure stripping across the wider Coma cluster. The results are equally spectacular as the first two examples. The geometry of the interactions in some cases allows us to estimate the various time scales involved, including gas flows out of the disk leading to creation of the ICM, and the attendant triggered star formation in the galaxy disks. The global star formation patterns and wholesale tidal stripping of matter yield insights into the spatial and temporal ISM-ICM interactions driving the evolution of galaxies in clusters and ultimately transforming their morphologies from spiral to S0. These processes, much more common in the early Universe, led to the wholesale morphological transformation of Hubble types during the assembly of rich clusters, when the intergalactic populations and hot ICM were first being created and laid down from such stripping and destruction of their member galaxies.We also report on two instrumental aspects of WFC3: 1) using the filter pair F350LP and F600LP to create an extremely broad pseudo Blue-Red color to achieve the greatest observing efficiency with HST, and 2) a WFC3 CCD effect which leads to apparent quantization of background counts, making automatic sky determination challenging when using drizzlepac routines.

  20. Phase synchronization in electroencephalographic recordings prognosticates outcome in paediatric coma.

    Science.gov (United States)

    Nenadovic, Vera; Perez Velazquez, Jose Luis; Hutchison, James Saunders

    2014-01-01

    Brain injury from trauma, cardiac arrest or stroke is the most important cause of death and acquired disability in the paediatric population. Due to the lifetime impact of brain injury, there is a need for methods to stratify patient risk and ultimately predict outcome. Early prognosis is fundamental to the implementation of interventions to improve recovery, but no clinical model as yet exists. Healthy physiology is associated with a relative high variability of physiologic signals in organ systems. This was first evaluated in heart rate variability research. Brain variability can be quantified through electroencephalographic (EEG) phase synchrony. We hypothesised that variability in brain signals from EEG recordings would correlate with patient outcome after brain injury. Lower variability in EEG phase synchronization, would be associated with poor patient prognosis. A retrospective study, spanning 10 years (2000-2010) analysed the scalp EEGs of children aged 1 month to 17 years in coma (Glasgow Coma Scale, GCS, <8) admitted to the paediatric critical care unit (PCCU) following brain injury from TBI, cardiac arrest or stroke. Phase synchrony of the EEGs was evaluated using the Hilbert transform and the variability of the phase synchrony calculated. Outcome was evaluated using the 6 point Paediatric Performance Category Score (PCPC) based on chart review at the time of hospital discharge. Outcome was dichotomized to good outcome (PCPC score 1 to 3) and poor outcome (PCPC score 4 to 6). Children who had a poor outcome following brain injury secondary to cardiac arrest, TBI or stroke, had a higher magnitude of synchrony (R index), a lower spatial complexity of the synchrony patterns and a lower temporal variability of the synchrony index values at 15 Hz when compared to those patients with a good outcome.

  1. Auditory event-related potentials as indicators of good prognosis in coma of non-anoxic etiology

    OpenAIRE

    2010-01-01

    The aim of this study is to evaluate whether auditory event-related potentials can predict the prognosis of recovery from coma resulting from different etiologies. The results of this study could then be used as an adjuvant test in helping the clinician evaluate patients in coma. We performed P300 auditory event-related potentials on 21 patients who developed a state of coma at our institution. We compared the results to the Glasgow coma scale at the onset of coma, on day 3, and day 21. We...

  2. Estudio clínico del proceso conductual de la emergencia del coma grave por accidente cerebrovascular

    OpenAIRE

    2007-01-01

    Objetivos: Estudiar el proceso de la emergencia del coma en pacientes en coma grave por accidente cerebrovascular (ACV). Método: Se han evaluado a 32 pacientes ingresados en una unidad de cuidados intensivos por un coma de origen cerebrovascular. Se ha realizado un seguimiento diario por neuropsicólogos e intensivistas y monitorizado el despertar del coma mediante 8 escalas de evalua ... ción clínica de los niveles de coma. Se han analizado las variables: edad, género, residencia, índice prem...

  3. The HST/ACS Coma Cluster Survey - VII. Structure and Assembly of Massive Galaxies in the Center of the Coma Cluster

    CERN Document Server

    Weinzirl, Tim; Neistein, Eyal; Khochfar, Sadegh; Kormendy, John; Marinova, Irina; Hoyos, Carlos; Balcells, Marc; Brok, Mark den; Hammer, Derek; Peletier, Reynier F; Kleijn, Gijs Verdoes; Carter, David; Goudfrooij, Paul; Mobasher, Bahram; Trentham, Neil; Erwin, Peter; Puzia, Thomas

    2013-01-01

    We constrain the assembly history of galaxies in the central 0.6 Mpc of the rich Coma cluster at z~0.02 based on the structure of 69 massive (M*>1e9 M_sun) galaxies using images from the HST Treasury Survey of Coma. Our findings are: (1) We make no a priori assumptions on the shape of the profile for outer and central structures, which can include disk-dominated components, bars, and classical bulges/ellipticals. After excluding the 2 cDs, we find that most (56%) of the galactic stellar mass resides in classical bulges/Es while (44%) resides in cold disk-dominated structures. This suggests that most of the stellar mass in Coma galaxies may have been assembled and shaped through the redistribution of stars during major mergers, and possibly minor mergers, but that gas-rich dissipative processes that build disk-dominated structures remain important even in the center of a rich cluster like Coma. (2) We see strong evidence of a morphology-density relation. In the central 0.6 Mpc of the Coma cluster, there are 2 ...

  4. Streaming Clumps Ejection Model and the Heterogeneous Inner Coma of Comet Wild 2

    Science.gov (United States)

    Clark, B. C.; Economou, T. E.; Green, S. F.; Sandford, S. A.; Zolensky, M. E.

    2004-01-01

    The conventional concept of cometary comae is that they are dominated by fine particulates released individually by sublimation of surface volatiles and subsequent entrainment in the near-surface gas. It has long been recognized that such particulates could be relatively large, with early estimates that objects perhaps up to one meter in size may be levitated from the surface of the typical cometary nucleus. However, the general uniformity and small average particulate size of observed comae and the relatively smooth, monotonic increases and decreases in particle density during the Giotto flythrough of comet Halley s coma in 1986 reinforced the view that the bulk of the particles are released at the surface, are fine-sized and inert. Jets have been interpreted as geometrically constrained release of these particulates. With major heterogeneities observed during the recent flythrough of the inner coma of comet Wild 2, these views deserve reconsideration.

  5. [Coma following chemotherapy: is 5FU implicated? Discussion about on case-report].

    Science.gov (United States)

    Heluwaert, Frédéric; Santre, Charles; Martin, Claude; Hilleret, Marie-Noëlle; Martin, Denis

    2006-02-01

    5FU is one of the most frequently used antioncogenic and cytostatic drug in digestive oncology. It may cause severe adverse events, such as encephalopathy, possibly based on hyperammoniemia, and may lead to coma. We report here the case of a coma with a favorable outcome following 5FU chemotherapy. As any other etiologic findings came to light, hyperammoniemia was discussed as a credible cause.

  6. VizieR Online Data Catalog: HST/ACS Coma Cluster Survey. X. (den Brok+, 2014)

    NARCIS (Netherlands)

    den Brok, M.; Peletier, R. F.; Seth, A.; Balcells, M.; Dominguez, L.; Graham, A. W.; Carter, D.; Erwin, P.; Ferguson, H. C.; Goudfrooij, P.; Guzman, R.; Hoyos, C.; Jogee, S.; Lucey, J.; Phillipps, S.; Puzia, T.; Valentijn, E.; Kleijn, G. V.; Weinzirl, T.

    2014-01-01

    The Coma ACS Survey (Carter et al., 2008ApJS..176..424C) provides data in two passbands for 25 fields pointed at the core of the Coma cluster and at the outskirts. The exposure times in the two passbands, F814W and F475W (which are roughly equivalent to the IC and g band) were ~1400 and ~2600s. The

  7. Against the odds: a case study of recovery from coma after devastating prognosis

    OpenAIRE

    2015-01-01

    Abstract To demonstrate the possibility for hidden rehabilitation potential even following most severe brain injury and the uncertainty of current prognosis factors for coma and unresponsive wakefulness syndrome, we detail the rehabilitation of J. W., after coma from traumatic brain injury. Originally, with many negative prognosis factors and several medical complications, prognosis was devastating. But, with continuing treatment, J. W. improved to a high level of independence in everyday lif...

  8. 'Is she alive? Is she dead?' Representations of chronic disorders of consciousness in Douglas Coupland's Girlfriend in a Coma.

    Science.gov (United States)

    Colbeck, Matthew

    2016-09-01

    Depictions of coma have come to dominate literary and filmic texts over the last half century, a phenomenon coinciding with advancements in medical technology that have led to remarkable increases in the survival rates of patients with chronic disorders of consciousness. Authors of coma fiction are preoccupied with the imagined subjective experience of coma, often creating complex, dream-like worlds from which the protagonist must escape if survival is to be achieved. However, such representations appear to conflict with medical case studies and patient narratives that reveal that most often survivors of coma have no recollection of the coma itself. Providing a close reading of Douglas Coupland's Girlfriend in a Coma (1998) against the context of medical literature and diagnoses, this article examines how the coma patient is represented, often depicting the realities of a prolonged vegetative state, in contrast with other popular representations of coma. It explores how the author develops a work of 'fantastic' fiction (a genre defined by the structuralist critic Tzvetan Todorov), using the condition of coma as a metaphor for a postmodern existential crisis, while simultaneously employing mimetic techniques that raise important medical, ethical and philosophical questions surrounding the ontological status of the comatose patient. It is argued that coma fiction, even in its misrepresentation of the condition, can help us to engage with and interrogate how we think about chronic disorders of consciousness, thereby providing a valuable insight into our attitudes towards illness and mortality.

  9. Feeding impairs chill coma recovery in the migratory locust (Locusta migratoria).

    Science.gov (United States)

    Andersen, Jonas Lembcke; Findsen, Anders; Overgaard, Johannes

    2013-10-01

    Low temperature causes loss of neuromuscular function in a wide range of insects, such that the animals enter a state known as chill coma. The ability to recover from chill coma (chill coma recovery time) is often a popular phenotype to characterise chill tolerance in insects. Chill coma in insects has been shown to be associated with a decrease in haemolymph volume and a marked increase in [K(+)], causing dissipation of K(+) equilibrium potential and resting membrane potential. High potassium diet (wheat) has also previously been shown to increase haemolymph [K(+)] in Locusta migratoria leading to sluggish behaviour. The present study combined these two independent stressors of ion and water homeostasis, in order to investigate the role of K(+)- and water-balance during recovery from chill coma, in the chill sensitive insect L. migratoria. We confirmed that cold shock elicits a fast increase in haemolymph [K(+)] which is likely caused by a water shift from the haemolymph to the muscles and other tissues. Recovery of haemolymph [K(+)] is however not only reliant on recovery of haemolymph volume, as the recovery of water and K(+) is decoupled. Chill coma recovery time, after 2h at -4 °C, differed significantly between fasted animals and those fed on high K(+) diet. This difference was not associated with an increased disturbance of haemolymph [K(+)] in the fed animals, instead it was associated with a slowed recovery of muscle [K(+)], muslce water, haemolymph [Na(+)] and K(+)equilibrium potential in the fed animals.

  10. MMN and novelty P3 in coma and other altered states of consciousness: a review.

    Science.gov (United States)

    Morlet, Dominique; Fischer, Catherine

    2014-07-01

    In recent decades, there has been a growing interest in the assessment of patients in altered states of consciousness. There is a need for accurate and early prediction of awakening and recovery from coma. Neurophysiological assessment of coma was once restricted to brainstem auditory and primary cortex somatosensory evoked potentials elicited in the 30 ms range, which have both shown good predictive value for poor coma outcome only. In this paper, we review how passive auditory oddball paradigms including deviant and novel sounds have proved their efficiency in assessing brain function at a higher level, without requiring the patient's active involvement, thus providing an enhanced tool for the prediction of coma outcome. The presence of an MMN in response to deviant stimuli highlights preserved automatic sensory memory processes. Recorded during coma, MMN has shown high specificity as a predictor of recovery of consciousness. The presence of a novelty P3 in response to the subject's own first name presented as a novel (rare) stimulus has shown a good correlation with coma awakening. There is now a growing interest in the search for markers of consciousness, if there are any, in unresponsive patients (chronic vegetative or minimally conscious states). We discuss the different ERP patterns observed in these patients. The presence of novelty P3, including parietal components and possibly followed by a late parietal positivity, raises the possibility that some awareness processes are at work in these unresponsive patients.

  11. A massive warm baryonic halo in the Coma cluster

    CERN Document Server

    Bonamente, M; Lieu, R

    2003-01-01

    Several deep PSPC observations of the Coma cluster reveal a very large-scale halo of soft X-ray emission, substantially in excess of the well known radiation from the hot intra-cluster medium. The excess emission, previously reported in the central region of the cluster using lower-sensitivity EUVE and ROSAT data, is now evident out to a radius of 2.6 Mpc, demonstrating that the soft excess radiation from clusters is a phenomenon of cosmological significance. The X-ray spectrum at these large radii cannot be modeled non-thermally, but is consistent with the original scenario of thermal emission from warm gas at ~ 10^6 K. The mass of the warm gas is on par with that of the hot X-ray emitting plasma, and significantly more massive if the warm gas resides in low-density filamentary structures. Thus the data lend vital support to current theories of cosmic evolution, which predict that at low redshift \\~30-40 % of the baryons reside in warm filaments converging at clusters of galaxies.

  12. Age and Metallicities of Cluster Galaxies: A1185 and Coma

    CERN Document Server

    Rakos, K; Odell, A

    2006-01-01

    We present age and metallicities determinations based on narrow band continuum colors for the galaxies in the rich clusters A1185 and Coma. Using a new technique to extract luminosity-weighted age and [Fe/H] values for non-star-forming galaxies, we find that both clusters have two separate populations based on these parameters. One population is old ($\\tau >$ 11 Gyrs) with a distinct mass-metallicity relation. The second population is slightly younger ($\\tau \\approx$ 9 Gyrs) with lower metallicities and lower stellar masses. We find detectable correlations between age and galaxy mass in both populations such that older galaxies are more massive and have higher mean metallicities, confirming previous work with line indices for the same type of galaxies in other clusters (Kelson et al 2006, Thomas et al 2005). Our results imply shorter durations for higher mass galaxies, in contradiction to the predictions of classic galactic wind models. Since we also find a clear mass-metallicity relation for these galaxies, ...

  13. Approximately A Thousand Ultra Diffuse Galaxies in the Coma cluster

    CERN Document Server

    Koda, Jin; Yamanoi, Hitomi; Komiyama, Yutaka

    2015-01-01

    We report the discovery of 854 ultra diffuse galaxies (UDGs) in the Coma cluster using deep R band images, with partial B, i, and Halpha band coverage, obtained with the Subaru telescope. Many of them (332) are Milky Way-sized with very large effective radii of r_e>1.5kpc. This study was motivated by the recent discovery of 47 UDGs by van-Dokkum et al. (2015); our discovery suggests >1,000 UDGs after accounting for the smaller Subaru field. The new UDGs show a distribution concentrated around the cluster center, strongly suggesting that the great majority are (likely longtime) cluster members. They are a passively evolving population, lying along the red sequence in the CM diagram with no Halpha signature. Star formation was, therefore, quenched in the past. They have exponential light profiles, effective radii re ~ 800 pc- 5 kpc, effective surface brightnesses mu_e(R)=25-28 mag arcsec-2, and stellar masses ~1x10^7 - 5x10^8Msun. There is also a population of nucleated UDGs. Some MW-sized UDGs appear closer to...

  14. Stability of auditory event-related potentials in coma research.

    Science.gov (United States)

    Schorr, Barbara; Schlee, Winfried; Arndt, Marion; Lulé, Dorothée; Kolassa, Iris-Tatjana; Lopez-Rolon, Alex; Lopez-Rolon, Alexander; Bender, Andreas

    2015-02-01

    Patients with unresponsive wakefulness syndrome (UWS) or in minimally conscious state (MCS) after brain injury show significant fluctuations in their behavioural abilities over time. As the importance of event-related potentials (ERPs) in the detection of traces of consciousness increases, we investigated the retest reliability of ERPs with repeated tests at four different time points. Twelve healthy controls and 12 inpatients (8 UWS, 4 MCS; 6 traumatic, 6 non-traumatic) were tested twice a day (morning, afternoon) for 2 days with an auditory oddball task. ERPs were recorded with a 256-channel-EEG system, and correlated with behavioural test scores in the Coma Recovery Scale-revised (CRS-R). The number of identifiable P300 responses varied between zero and four in both groups. Reliabilities varied between Krippendorff's α = 0.43 for within-day comparison, and α = 0.25 for between-day comparison in the patient group. Retest reliability was strong for the CRS-R scores for all comparisons (α = 0.83-0.95). The stability of auditory information processing in patients with disorders of consciousness is the basis for other, even more demanding tasks and cognitive potentials. The relatively low ERP-retest reliability suggests that it is necessary to perform repeated tests, especially when probing for consciousness with ERPs. A single negative ERP test result may be mistaken for proof that a UWS patient truly is unresponsive.

  15. Disability rating scale for severe head trauma: coma to community.

    Science.gov (United States)

    Rappaport, M; Hall, K M; Hopkins, K; Belleza, T; Cope, D N

    1982-03-01

    The objective of this study was to develop one instrument for assessing quantitatively the disability of severe head trauma patients so their rehabilitative progress could be followed from coma through different levels of awareness and functioning to their return to the community. This disability rating (DR) instrument was designed to be easily learned, quickly completed, valid, predictive of outcome and to have a high inter-rater reliability. The DR Scale consists of 8 items divided into 4 categories; 1. Arousal and awareness; 2. Cognitive ability to handle self-care functions; 3. Physical dependence upon others; 4. Psychosocial adaptability for work, housework, or school. Completed independently by several raters for more than 88 serious head injury patients, inter-rater correlations were highly significant. The admission DR was significantly related to clinical outcome at 1 year after injury and was significantly related to electrophysiologic measures of brain dysfunction as reflected in degree of abnormality of evoked brain potential patterns. The DR Scale is more sensitive than the Glasgow Outcome Scale in detecting and measuring clinical changes in individuals who have sustained severe head trauma. Also it can be used to help identify patients most likely to benefit from intensive rehabilitation care within a hospital setting. It provides a shorthand global description of a head injury patient's condition that facilitates understanding and communication.

  16. Seizure and coma following Kratom (Mitragynina speciosa Korth) exposure.

    Science.gov (United States)

    Nelsen, Jamie L; Lapoint, Jeff; Hodgman, Michael J; Aldous, Kenneth M

    2010-12-01

    Reports of toxicity secondary to Kratom are rare and lack of diagnostic testing in human specimens has prevented confirmatory explanation of observed clinical effects. We present a novel case of serious human toxicity following Kratom use confirmed via quantitative analysis of urine by high performance liquid chromatography coupled to electrospray tandem mass spectrometry. A 64 year-old male was witnessed to have a seizure at home following kratom consumption. Upon arrival to the emergency department (ED), the patient was unresponsive. While in the ED, the patient sustained a second seizure. He was intubated to protect his airway. The remainder of his hospital course was uneventful. A urine specimen was collected shortly after admission and sent for analysis. The mitragynine concentration in the urine was 167 ± 15 ng/ml. We report a rare case of Kratom toxicity characterized by a seizure and coma confirmed by urinary analysis of mitragynine by high performance liquid chromatography coupled to electrospray tandem mass spectrometry. The proposed mechanism for this reaction is unclear but suggested mechanisms include adenosine binding or stimulation of adrenergic and/or serotonergic receptors similar to tramadol.

  17. Dwarf Galaxies in the Coma Cluster: I. Velocity Dispersion Measurements

    CERN Document Server

    Kourkchi, E; Carter, D; Karick, A M; Mármol-Queraltó, E; Chiboucas, K; Tully, R B; Mobasher, B; Guzmán, R; Matković, A; Gruel, N

    2011-01-01

    We present the study of a large sample of early-type dwarf galaxies in the Coma cluster observed with DEIMOS on the Keck II to determine their internal velocity dispersion. We focus on a subsample of 41 member dwarf elliptical galaxies for which the velocity dispersion can be reliably measured, 26 of which were studied for the first time. The magnitude range of our sample is $-21

  18. Interactions between non-barbiturate injectable anesthetics and conventional antiepileptic drugs in the maximal electroshock test in mice--an isobolographic analysis.

    Science.gov (United States)

    Borowicz, Kinga K; Łuszczki, Jarogniew; Czuczwar, Stanisław J

    2004-03-01

    The aim of this study was the isobolographic evaluation of interactions between three non-barbiturate intravenous anesthetics and conventional antiepileptic drugs in the maximal electroshock-induced seizures in mice. Electroconvulsions were produced by means of an alternating current (ear-clip electrodes, 0.2-s stimulus duration, tonic hindlimb extension taken as the endpoint). Adverse effects were evaluated in the chimney test (motor performance) and passive avoidance task (long-term memory). Plasma levels of antiepileptic drugs were measured by immunofluorescence. Obtained results indicate that ketamine acts synergistically with valproate and carbamazepine. Also the combinations of propofol and valproate or phenobarbital led to synergistic interactions. An antagonism was found between etomidate and carbamazepine or phenobarbital. On the other hand, interactions between diphenylhydantoin and injectable anesthetics proved to be additive. The only exception was the combination of diphenylhydantoin and propofol (1:3). Pharmacokinetic phenomena do not seem to interfere with the observed interactions, since none of anesthetics influenced the free plasma concentrations of antiepileptic drugs. Referring to undesired effects, only propofol impaired long-term memory. Although propofol did not disturbed motor coordination, it enhanced motor impairment caused by carbamazepine and diphenylhydantoin. Results of the present study suggest that etomidate needs to be avoided in epileptic patients due to a possibility of negative interactions with some antiepileptic drugs and seizure precipitation.

  19. A new synthetic methodology for the preparation of biocompatible and organo-soluble barbituric- and thiobarbituric acid based chitosan derivatives for biomedical applications

    Energy Technology Data Exchange (ETDEWEB)

    Shahzad, Sohail [Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore 54000 (Pakistan); Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100 (Pakistan); Shahzadi, Lubna [Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore 54000 (Pakistan); Mahmood, Nasir [Department of Allied Health Sciences and Chemical Pathology, Department of Human Genetics and Molecular Biology, University of Health Sciences, Lahore (Pakistan); Siddiqi, Saadat Anwar [Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore 54000 (Pakistan); Rauf, Abdul [Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100 (Pakistan); Manzoor, Faisal; Chaudhry, Aqif Anwar [Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore 54000 (Pakistan); Rehman, Ihtesham ur [Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore 54000 (Pakistan); Department of Materials Science and Engineering, The Kroto Research Institute, The University of Sheffield, North Campus, Broad Lane, Sheffield, S3 7HQ (United Kingdom); Yar, Muhammad, E-mail: drmyar@ciitlahore.edu.pk [Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore 54000 (Pakistan)

    2016-09-01

    Chitosan's poor solubility especially in organic solvents limits its use with other organo-soluble polymers; however such combinations are highly required to tailor their properties for specific biomedical applications. This paper describes the development of a new synthetic methodology for the synthesis of organo-soluble chitosan derivatives. These derivatives were synthesized from chitosan (CS), triethyl orthoformate and barbituric or thiobarbituric acid in the presence of 2-butannol. The chemical interactions and new functional motifs in the synthesized CS derivatives were evaluated by FTIR, DSC/TGA, UV/VIS, XRD and {sup 1}H NMR spectroscopy. A cytotoxicity investigation for these materials was performed by cell culture method using VERO cell line and all the synthesized derivatives were found to be non-toxic. The solubility analysis showed that these derivatives were readily soluble in organic solvents including DMSO and DMF. Their potential to use with organo-soluble commercially available polymers was exploited by electrospinning; the synthesized derivatives in combination with polycaprolactone delivered nanofibrous membranes. - Highlights: • Development of a new synthetic methodology • Synthesis of organo-soluble chitosan (CS) derivatives • VERO cells proliferation • Nanofibrous membranes from the synthesized chitosan derivatives and polycaprolactone.

  20. The HST/ACS Coma Cluster Survey. IV. Intergalactic Globular Clusters and the Massive Globular Cluster System at the Core of the Coma Galaxy Cluster

    NARCIS (Netherlands)

    Peng, Eric W.; Ferguson, Henry C.; Goudfrooij, Paul; Hammer, Derek; Lucey, John R.; Marzke, Ronald O.; Puzia, Thomas H.; Carter, David; Balcells, Marc; Bridges, Terry; Chiboucas, Kristin; del Burgo, Carlos; Graham, Alister W.; Guzmán, Rafael; Hudson, Michael J.; Matković, Ana; Merritt, David; Miller, Bryan W.; Mouhcine, Mustapha; Phillipps, Steven; Sharples, Ray; Smith, Russell J.; Tully, Brent; Verdoes Kleijn, Gijs

    2011-01-01

    Intracluster stellar populations are a natural result of tidal interactions in galaxy clusters. Measuring these populations is difficult, but important for understanding the assembly of the most massive galaxies. The Coma cluster of galaxies is one of the nearest truly massive galaxy clusters and is

  1. The HST/ACS Coma Cluster Survey : IV. Intergalactic Globular Clusters and the Massive Globular Cluster System at the Core of the Coma Galaxy Cluster

    NARCIS (Netherlands)

    Peng, Eric W.; Ferguson, Henry C.; Goudfrooij, Paul; Hammer, Derek; Lucey, John R.; Marzke, Ronald O.; Puzia, Thomas H.; Carter, David; Balcells, Marc; Bridges, Terry; Chiboucas, Kristin; del Burgo, Carlos; Graham, Alister W.; Guzman, Rafael; Hudson, Michael J.; Matkovic, Ana; Merritt, David; Miller, Bryan W.; Mouhcine, Mustapha; Phillipps, Steven; Sharples, Ray; Smith, Russell J.; Tully, Brent; Kleijn, Gijs Verdoes

    2011-01-01

    Intracluster stellar populations are a natural result of tidal interactions in galaxy clusters. Measuring these populations is difficult, but important for understanding the assembly of the most massive galaxies. The Coma cluster of galaxies is one of the nearest truly massive galaxy clusters and is

  2. Assessment of refractive astigmatism and simulated therapeutic refractive surgery strategies in coma-like-aberrations-dominant corneal optics

    OpenAIRE

    ZHOU Wen; Stojanovic, Aleksandar; Utheim, Tor Paaske

    2016-01-01

    Background The aim of the study is to raise the awareness of the influence of coma-like higher-order aberrations (HOAs) on power and orientation of refractive astigmatism (RA) and to explore how to account for that influence in the planning of topography-guided refractive surgery in eyes with coma-like-aberrations-dominant corneal optics. Methods Eleven eyes with coma-like-aberrations-dominant corneal optics and with low lenticular astigmatism (LA) were selected for astigmatism analysis and f...

  3. Development of an objective tool for the diagnosis of myxedema coma.

    Science.gov (United States)

    Chiong, Yien V; Bammerlin, Elaine; Mariash, Cary N

    2015-09-01

    Myxedema coma, a rare entity, with a reported 25%-65% mortality had no objective criteria for making the diagnosis when we began our study. We developed an objective screening tool for myxedema coma to more easily identify patients and examine the best treatment method in future prospective studies to reduce the mortality of this entity. We conducted a retrospective chart review to find all patients aged ≥18 years admitted with myxedema coma from January 1, 2005 through June 13, 2010 at Indiana University Health Methodist Hospital. On the basis of both our retrospective chart review and on literature accounts, we identified 6 criteria to diagnose myxedema coma. We identified 10 patients initially diagnosed with myxedema coma and established a control group consisting of 13 patients identified with altered mental status and increased thyroid-stimulating hormone (TSH) levels. The 6 variables we created for the screening tool were heart rate, temperature, Glasgow coma scale, TSH, free thyroxine, and precipitating factors. The screening tool has a sensitivity and specificity of about 80%. We ran a logistic regression model using the 10 study patients and 13 controls with the 6 variables. No variables alone significantly contributed to the model. However, the overall model was highly significant (P = 0.012), providing strong support for a scoring system that uses these variables simultaneously. This screening tool enables physicians to rapidly diagnose myxedema coma to expedite treatment. A more refined diagnostic tool may be used in future clinical studies designed to determine the optimal treatment.

  4. One barbiturate and two solvated thiobarbiturates containing the triply hydrogen-bonded ADA/DAD synthon, plus one ansolvate and three solvates of their coformer 2,4-diaminopyrimidine.

    Science.gov (United States)

    Hützler, Wilhelm Maximilian; Egert, Ernst; Bolte, Michael

    2016-09-01

    A path to new synthons for application in crystal engineering is the replacement of a strong hydrogen-bond acceptor, like a C=O group, with a weaker acceptor, like a C=S group, in doubly or triply hydrogen-bonded synthons. For instance, if the C=O group at the 2-position of barbituric acid is changed into a C=S group, 2-thiobarbituric acid is obtained. Each of the compounds comprises two ADA hydrogen-bonding sites (D = donor and A = acceptor). We report the results of cocrystallization experiments of barbituric acid and 2-thiobarbituric acid, respectively, with 2,4-diaminopyrimidine, which contains a complementary DAD hydrogen-bonding site and is therefore capable of forming an ADA/DAD synthon with barbituric acid and 2-thiobarbituric acid. In addition, pure 2,4-diaminopyrimidine was crystallized in order to study its preferred hydrogen-bonding motifs. The experiments yielded one ansolvate of 2,4-diaminopyrimidine (pyrimidine-2,4-diamine, DAPY), C4H6N4, (I), three solvates of DAPY, namely 2,4-diaminopyrimidine-1,4-dioxane (2/1), 2C4H6N4·C4H8O2, (II), 2,4-diaminopyrimidine-N,N-dimethylacetamide (1/1), C4H6N4·C4H9NO, (III), and 2,4-diaminopyrimidine-1-methylpyrrolidin-2-one (1/1), C4H6N4·C5H9NO, (IV), one salt of barbituric acid, viz. 2,4-diaminopyrimidinium barbiturate (barbiturate is 2,4,6-trioxopyrimidin-5-ide), C4H7N4(+)·C4H3N2O3(-), (V), and two solvated salts of 2-thiobarbituric acid, viz. 2,4-diaminopyrimidinium 2-thiobarbiturate-N,N-dimethylformamide (1/2) (2-thiobarbiturate is 4,6-dioxo-2-sulfanylidenepyrimidin-5-ide), C4H7N4(+)·C4H3N2O2S(-)·2C3H7NO, (VI), and 2,4-diaminopyrimidinium 2-thiobarbiturate-N,N-dimethylacetamide (1/2), C4H7N4(+)·C4H3N2O2S(-)·2C4H9NO, (VII). The ADA/DAD synthon was succesfully formed in the salt of barbituric acid, i.e. (V), as well as in the salts of 2-thiobarbituric acid, i.e. (VI) and (VII). In the crystal structures of 2,4-diaminopyrimidine, i.e. (I)-(IV), R2(2)(8) N-H...N hydrogen-bond motifs are preferred and, in two

  5. Induction of burst suppression or coma using intravenous anesthetics in refractory status epilepticus.

    Science.gov (United States)

    Kang, Bong Su; Jung, Keun-Hwa; Shin, Jeong-Won; Moon, Jang Sup; Byun, Jung-Ick; Lim, Jung-Ah; Moon, Hye Jin; Kim, Young-Soo; Lee, Soon-Tae; Chu, Kon; Lee, Sang Kun

    2015-05-01

    General anesthetic-induced coma therapy has been recommended for the treatment of refractory status epilepticus (RSE). However, the influence of electroencephalographic (EEG) burst suppression (BS) on outcomes still remains unclear. This study investigated the impact of intravenous anesthetic-induced BS on the prognosis of RSE using a retrospective analysis of all consecutive adult patients who received intravenous anesthetic treatment for RSE at the Seoul National University Hospital between January 2006 and June 2011. Twenty-two of the 111 episodes of RSE were enrolled in this study. Of the 22 RSE patients, 12 (54.5%) were women and 18 (81.4%) exhibited generalized convulsive status epilepticus. Sixteen patients (72.7%) were classified as having acute symptomatic etiology, including three patients with anoxic encephalopathy, and others with remote symptomatic etiology. Only two patients (9.1%) had a favorable Status Epilepticus Severity Score (0-2) at admission. All patients received midazolam (MDZ) as a primary intravenous anesthetic drug for RSE treatment; three (13.6%) received MDZ and propofol, and one (4.5%) received MDZ and pentobarbital. The rates of mortality and poor outcome at discharge were 13.6% (n=3) and 54.5% (n=12), respectively. While BS was achieved in six (27.5%) patients, it was not associated with mortality or poor outcome. Induced BS was associated with prolonged hospital stay in subgroup analysis when excluding anoxic encephalopathy. Our results suggest that induction of BS for treating RSE did not affect mortality or outcome at discharge and may lead to an increased length of hospital stay.

  6. Non-Doppler Redshift and Dark Matter in the Coma Cluster

    CERN Document Server

    Zheng, Yi-Jia

    2013-01-01

    In 1929 Zwicky proposed a tired light theory to interpret the Hubble law (Hubble 1929). The key of the tired light theory is to interpret the observed redshift of galaxy as the non-Doppler effect. But the derivation of the dark matter in the Coma cluster proposed by Zwicky in 1933 was based on the interpretation that redshifts of galaxies were the Doppler effect, and the non-Doppler effect was not considered at all. However, if there is a reasonable non-Doppler effect and the great majority of the observed redshifts of galaxies in the Coma cluster can be interpreted by the non-Doppler effect, then it's not needed to introduce the dark matter in the Coma cluster to keep the stability of the cluster. In this paper it is shown that the great majority of the redshifts of galaxies in the Coma cluster are caused by the non-Doppler redshift proposed by Zheng (2013), and a numerical estimation of the redshifts of galaxies in the Coma cluster is presented.

  7. Uncovering the Near-IR Dwarf Galaxy Population of the Coma Cluster with Spitzer IRAC

    CERN Document Server

    Jenkins, L P; Mobasher, B; Alexander, D M; Bauer, F E

    2007-01-01

    We present the first results of a Spitzer IRAC (Infrared Array Camera) wide-field survey of two regions of the Coma cluster, in which we detect a large population of dwarf galaxies. The observations cover two fields of different galaxy densities; the first is a 0.733 deg^2 region in the core of the cluster (Coma 1), the second a 0.555 deg^2 off-center region located ~57 arcmin (1.7 Mpc) south-west from the center (Coma 3). The observations, although short 70-90 second exposures, are very sensitive; we detect ~29200 sources at 3.6 micron over the total ~1.3 deg^2 survey area. After identifying and excluding foreground stars, we construct 3.6 micron galaxy luminosity functions (LFs) for each field using selection functions based on spectroscopic redshifts to account for background objects. At the bright end, the LFs are well modeled by a traditional Schechter function; [M^star (3.6 micron), alpha_1] = [-25.17, -1.18] and [-24.69, -1.30] for Coma 1 and Coma 3 respectively. However, at the faint end M(3.6 micron)...

  8. The diffuse soft excess emission in the Coma cluster from the ROSAT All-Sky Survey

    CERN Document Server

    Bonamente, Max; Bulbul, Esra

    2009-01-01

    RASS data near the North Galactic Pole was analyzed in order to study the large-scale distribution of soft X-ray emission from the Coma cluster. These RASS data constitute the only available X-ray observations of Coma that feature an in situ -- temporally and spatially contiguous -- background, with unlimited and continuous radial coverage. These unique characteristics of the RASS data are used to deliver a final assessment on whether the soft excess previously detected in the Coma cluster is due to background subtraction errors, or not. This paper confirms the presence of soft X-ray excess associated with Coma, and reports the detection of 1/4 keV band excess out to 5 Mpc from the cluster center, the largest soft excess halo discovered to date. We propose that the emission is related to filaments that converge towards Coma, and generated either by non-thermal radiation caused by accretion shocks, or by thermal emission from the filaments themselves.

  9. Abundant molecular oxygen in the coma of comet 67P/Churyumov-Gerasimenko.

    Science.gov (United States)

    Bieler, A; Altwegg, K; Balsiger, H; Bar-Nun, A; Berthelier, J-J; Bochsler, P; Briois, C; Calmonte, U; Combi, M; De Keyser, J; van Dishoeck, E F; Fiethe, B; Fuselier, S A; Gasc, S; Gombosi, T I; Hansen, K C; Hässig, M; Jäckel, A; Kopp, E; Korth, A; Le Roy, L; Mall, U; Maggiolo, R; Marty, B; Mousis, O; Owen, T; Rème, H; Rubin, M; Sémon, T; Tzou, C-Y; Waite, J H; Walsh, C; Wurz, P

    2015-10-29

    The composition of the neutral gas comas of most comets is dominated by H2O, CO and CO2, typically comprising as much as 95 per cent of the total gas density. In addition, cometary comas have been found to contain a rich array of other molecules, including sulfuric compounds and complex hydrocarbons. Molecular oxygen (O2), however, despite its detection on other icy bodies such as the moons of Jupiter and Saturn, has remained undetected in cometary comas. Here we report in situ measurement of O2 in the coma of comet 67P/Churyumov-Gerasimenko, with local abundances ranging from one per cent to ten per cent relative to H2O and with a mean value of 3.80 ± 0.85 per cent. Our observations indicate that the O2/H2O ratio is isotropic in the coma and does not change systematically with heliocentric distance. This suggests that primordial O2 was incorporated into the nucleus during the comet's formation, which is unexpected given the low upper limits from remote sensing observations. Current Solar System formation models do not predict conditions that would allow this to occur.

  10. [Early prognosis in severe cranio-cerebral trauma using the Glasgow Coma Score and evoked potentials].

    Science.gov (United States)

    Riffel, B; Stöhr, M; Graser, W; Trost, E; Baumgärtner, H

    1989-02-01

    During 72 h following severe head injury, 103 patients in acute posttraumatic coma were assessed by clinical examinations (documented by Glasgow Coma Score) and brain stem auditory evoked potentials (BAEP) as well as short-latency somatosensory evoked potentials (SEP) following median-nerve stimulation. Patient outcomes were classified at 6 months or more according to the following categories: good recovery, severely disabled or vegetative, and brain dead. Patients who had died of systemic complications (pneumonia, septicemia, renal failure, etc.) were excluded from the study. The Glasgow Coma Score was reliable in forecasting a favorable outcome; all patients with a Score over 9 points had a good recovery. The Glasgow Coma Score was not reliable in predicting an unfavorable outcome, however; some patients with the lowest possible Glasgow Coma Score (3 points) at the early clinical examination survived with good recovery. The BAEPs were reliable predictors of an unfavorable outcome; the outcome was unfavorable when a missing wave V or more missing waves pointed toward a secondary brainstem lesion. Normal BAEPs were not reliable, however, in predicting a favorable outcome. SEP data served as a prognostic indicator of unfavorable as well as favorable outcomes. In summary, evoked potentials add valuable information to the clinical examination in assessing a patient's outcome after severe head injury.

  11. Dark energy and the structure of the Coma cluster of galaxies

    Science.gov (United States)

    Chernin, A. D.; Bisnovatyi-Kogan, G. S.; Teerikorpi, P.; Valtonen, M. J.; Byrd, G. G.; Merafina, M.

    2013-05-01

    Context. We consider the Coma cluster of galaxies as a gravitationally bound physical system embedded in the perfectly uniform static dark energy background as implied by ΛCDM cosmology. Aims: We ask if the density of dark energy is high enough to affect the structure of a large and rich cluster of galaxies. Methods: We base our work on recent observational data on the Coma cluster, and apply our theory of local dynamical effects of dark energy, including the zero-gravity radius RZG of the local force field as the key parameter. Results: 1) Three masses are defined that characterize the structure of a regular cluster: the matter mass MM, the dark-energy effective mass MDE (antigravity affects the structure of the Coma cluster strongly at large radii R ≳ 14 Mpc and should be considered when its total mass is derived.

  12. Prognosis in prolonged coma patients with diffuse axonal injury assessed by somatosensory evoked potential

    Institute of Scientific and Technical Information of China (English)

    Xiujue Zheng; Mantao Chen; Jingqi Li; Fei Cao

    2013-01-01

    A total of 43 prolonged coma patients with diffuse axonal injury received the somatosensory evoked potential examination one month after injury in the First Affiliated Hospital, School of Medicine, Zhejiang University in China. Somatosensory evoked potentials were graded as normal, abnormal or absent (grades I–III) according to N20 amplitude and central conduction time. The outcome in patients with grade III somatosensory evoked potential was in each case unfavorable. The prognostic accuracy of grade III somatosensory evoked potential for unfavorable and non-awakening outcome was 100% and 80%, respectively. The prognostic accuracy of grade I somatosensory evoked potential for favorable and wakening outcome was 86% and 100%, respectively. These results suggest that somatosensory evoked potential grade is closely correlated with coma severity and degree of recovery. Somatosensory evoked potential is a valuable diagnostic tool to assess prognosis in prolonged coma patients with diffuse axonal injury.

  13. Glasgow Coma Scale, brain electric activity mapping and Glasgow Outcome Scale after hyperbaric oxygen treatment of severe brain injury

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective: To study the effect of hyperbaric oxygen (HBO) treatment of severe brain injury.Methods: Fifty-five patients were divided into a treatment group (n = 35 receiving HBO therapy ) and a control group (n = 20 receiving dehydrating, cortical steroid and antibiotic therapy) to observe the alteration of clinic GCS (Glasgow Coma Scale), brain electric activity mapping (BEAM), prognosis and GOS (Glasgow Outcome Scale) before and after hyperbaric oxygen treatment.Results: In the treatment group GCS, BEAM and GOS were improved obviously after 3 courses of treatment,GCS increased from 5.1 to 14.6 ( P < 0.01-0.001 ), the BEAM abnormal rate reduced from 94.3% to 38% (P <0.01-0.001 ), the GOS good-mild disability rate was 83.7%, and the middle-severe disability rate was 26.3%compared with the control group. There was a statistic significant difference between the two groups (P < 0.01-0.001).Conclusions: Hyperbaric oxygen treatment could improve obviously GCS, BEAM and GOS of severe brain injury patients, and effectively reduce the mortality and morbidity. It is an effective method to treat severe brain injury. two g

  14. Chill-coma recovery time, age and sex determine lipid profiles in Ceratitis capitata tissues.

    Science.gov (United States)

    Pujol-Lereis, Luciana Mercedes; Fagali, Natalia Soledad; Rabossi, Alejandro; Catalá, Ángel; Quesada-Allué, Luis Alberto

    2016-04-01

    The remodeling of membrane composition by changes in phospholipid head groups and fatty acids (FA) degree of unsaturation has been associated with the maintenance of membrane homeostasis under stress conditions. Overall lipid levels and the composition of cuticle lipids also influence insect stress resistance and tissue protection. In a previous study, we demonstrated differences in survival, behavior and Cu/Zn superoxide dismutase gene expression between subgroups of Ceratitis capitata flies that had a reversible recovery from chill-coma and those that developed chilling-injury. Here, we analyzed lipid profiles from comparable subgroups of 15 and 30-day-old flies separated according to their recovery time after a chill-coma treatment. Neutral and polar lipid classes of chill-coma subgroups were separated by thin layer chromatography and quantified by densitometry. FA composition of polar lipids of chill-coma subgroups and non-stressed flies was evaluated using gas chromatography coupled to mass spectrometry. Higher amounts of neutral lipids such as triglycerides, diacylglycerol, wax esters, sterol esters and free esters were found in male flies that recovered faster from chill-coma compared to slower flies. A multivariate analysis revealed changes in patterns of storage and cuticle lipids among subgroups both in males and females. FA unsaturation increased after cold exposure, and was higher in thorax of slower subgroups compared to faster subgroups. The changes in neutral lipid patterns and FA composition depended on recovery time, sex, age and body-part, and were not specifically associated with the development of chilling-injury. An analysis of phospholipid classes showed that the phosphatidylcholine to lysophosphatidylcholine ratio (PC/LPC) was significantly higher, or showed a tendency, in subgroups that may have developed chilling-injury compared to those with a reversible recovery from coma.

  15. Deep UV Luminosity Functions at the Infall Region of the Coma Cluster

    Science.gov (United States)

    Hammer, D. M.; Hornschemeier, A. E.; Salim, S.; Smith, R.; Jenkins, L.; Mobasher, B.; Miller, N.; Ferguson, H.

    2011-01-01

    We have used deep GALEX observations at the infall region of the Coma cluster to measure the faintest UV luminosity functions (LFs) presented for a rich galaxy cluster thus far. The Coma UV LFs are measured to M(sub uv) = -10.5 in the GALEX FUV and NUV bands, or 3.5 mag fainter than previous studies, and reach the dwarf early-type galaxy population in Coma for the first time. The Schechter faint-end slopes (alpha approximately equal to -1.39 in both GALEX bands) are shallower than reported in previous Coma UV LF studies owing to a flatter LF at faint magnitudes. A Gaussian-plus-Schechter model provides a slightly better parametrization of the UV LFs resulting in a faint-end slope of alpha approximately equal to -1.15 in both GALEX bands. The two-component model gives faint-end slopes shallower than alpha = -1 (a turnover) for the LFs constructed separately for passive and star forming galaxies. The UV LFs for star forming galaxies show a turnover at M(sub UV) approximately equal to -14 owing to a deficit of dwarf star forming galaxies in Coma with stellar masses below M(sub *) = 10(sup 8) solar mass. A similar turnover is identified in recent UV LFs measured for the Virgo cluster suggesting this may be a common feature of local galaxy clusters, whereas the field UV LFs continue to rise at faint magnitudes. We did not identify an excess of passive galaxies as would be expected if the missing dwarf star forming galaxies were quenched inside the cluster. In fact, the LFs for both dwarf passive and star forming galaxies show the same turnover at faint magnitudes. We discuss the possible origin of the missing dwarf star forming galaxies in Coma and their expected properties based on comparisons to local field galaxies.

  16. Prognosis of patients in coma after acute subdural hematoma due to ruptured intracranial aneurysm.

    Science.gov (United States)

    Torné, Ramon; Rodríguez-Hernández, Ana; Romero-Chala, Fabián; Arikan, Fuat; Vilalta, Jordi; Sahuquillo, Juan

    2016-04-01

    Acute subdural hematomas (aSDH) secondary to intracranial aneurysm rupture are rare. Most patients present with coma and their functional prognosis has been classically considered to be very poor. Previous studies mixed good-grade and poor-grade patients and reported variable outcomes. We reviewed our experience by focusing on patients in coma only and hypothesized that aSDH might worsen initial mortality but not long-term functional outcome. Between 2005 and 2013, 440 subarachnoid hemorrhage (SAH) patients were admitted to our center. Nineteen (4.3%) were found to have an associated aSDH and 13 (2.9%) of these presented with coma. Their prospectively collected clinical and outcome data were reviewed and compared with that of 104 SAH patients without aSDH who presented with coma during the same period. Median aSDH thickness was 10mm. Four patients presented with an associated aneurysmal cortical laceration and only one had good recovery. Overall, we observed good long-term outcomes in both SAH patients in coma with aSDH and those without aSDH (38.5% versus 26.4%). Associated aSDH does not appear to indicate a poorer long-term functional prognosis in SAH patients presenting with coma. Anisocoria and brain herniation are observed in patients with aSDH thicknesses that are smaller than those observed in trauma patients. Despite a high initial mortality, early surgery to remove the aSDH results in a good outcome in over 60% of survivors. Aneurysmal cortical laceration appears to be an independent entity which shows a poorer prognosis than other types of aneurysmal aSDH.

  17. Why do insects enter chill coma? Low temperature and high extracellular potassium compromises muscle function in Locusta migratoria

    DEFF Research Database (Denmark)

    Findsen, Anders; Pedersen, Thomas Holm; Nielsen, Ole Bækgaard

    Many insect species enter a comatose state when their body temperature is lowered to a critical limit (critical thermal minimum) but the physiological and cellular processes that underlie chill coma are still unresolved. Several studies have demonstrated that transition into chill-coma involves a...

  18. The HST/ACS Coma Cluster Survey : III. Structural parameters of galaxies using single Sersic fits star

    NARCIS (Netherlands)

    Hoyos, Carlos; den Brok, Mark; Verdoes Kleijn, Gijs; Carter, David; Balcells, Marc; Guzmán, Rafael; Peletier, Reynier; Ferguson, Henry C.; Goudfrooij, Paul; Graham, Alister W.; Hammer, Derek; Karick, Arna M.; Lucey, John R.; Matković, Ana; Merritt, David; Mouhcine, Mustapha; Valentijn, Edwin

    2011-01-01

    We present a catalogue of structural parameters for 8814 galaxies in the 25 fields of the Hubble Space Telescope/ACS Coma Treasury Survey. Parameters from Sersic fits to the two-dimensional surface brightness distributions are given for all galaxies from our published Coma photometric catalogue with

  19. The HST/ACS Coma Cluster Survey - III. Structural parameters of galaxies using single Sérsic fits

    NARCIS (Netherlands)

    Hoyos, Carlos; den Brok, Mark; Verdoes Kleijn, Gijs; Carter, David; Balcells, Marc; Guzmán, Rafael; Peletier, Reynier; Ferguson, Henry C.; Goudfrooij, Paul; Graham, Alister W.; Hammer, Derek; Karick, Arna M.; Lucey, John R.; Matković, Ana; Merritt, David; Mouhcine, Mustapha; Valentijn, Edwin

    2011-01-01

    We present a catalogue of structural parameters for 8814 galaxies in the 25 fields of the Hubble Space Telescope/ACS Coma Treasury Survey. Parameters from Sérsic fits to the two-dimensional surface brightness distributions are given for all galaxies from our published Coma photometric catalogue with

  20. Triple Experiment Spectrum of the Sunyaev-Zeldovich Effect in the Coma Cluster: H_0

    CERN Document Server

    Battistelli, E S; Lamagna, L; Luzzi, G; Maoli, R; Melchiorri, A; Melchiorri, F; Orlando, A E; Palladino, E; Savini, G; Rephaeli, Y; Shimon, M; Colafrancesco, S; Kreysa, E; Signore, M

    2003-01-01

    The Sunyaev-Zeldovich (SZ) effect was previously measured in the Coma cluster by the OVRO and MITO experiments, and recently also with the WMAP satellite. We assess the consistency of these results and their implications on the feasibility of high frequency SZ work with ground-based telescopes. The unique dataset from the combined measurements at six frequency bands is jointly analyzed to determine the Hubble constant, H_0, towards Coma: H_0 \\simeq (77 \\pm 20) km/(s Mpc), whose error include both y and X-ray data uncertainties.

  1. HST detection of spiral structure in two Coma Cluster dwarf galaxies

    CERN Document Server

    Graham, A W; Guzmán, R; Graham, Alister W.; Jerjen, Helmut; Guzman, Rafael

    2003-01-01

    We report the discovery of (stellar) spiral-like structure in Hubble Space Telescope images of two dwarf galaxies (GMP 3292 and GMP 3629) belonging to the Coma cluster. GMP 3629 is the faintest such galaxy detected in a cluster environment, and it is the first such galaxy observed in the dense Coma cluster. The large bulge and the faintness of the broad spiral-like pattern in GMP 3629 suggests that its disk may have been largely depleted. >We may therefore have found an example of the ``missing link'' in theories of galaxy evolution which have predicted that dwarf spiral galaxies, particularly in clusters, evolve into dwarf elliptical galaxies.

  2. Repeatability of the Dust and Gas Morphological Structures in the Coma of Comet

    Science.gov (United States)

    Lejoly, Cassandra; Samarasinha, N. H.; Ojha, L.; Schleicher, D. G.

    2013-10-01

    Comet 1P/Halley is the most famous comet in history and has been observed for over two millennia, making it one of the most extensively studied comets. The morphology in the coma of comet 1P/Halley originates due to the activity at the nucleus and could be used as a probe of the nuclear rotation and the activity. We will present the results from a study summarizing the evolution of coma morphology of comet 1P/Halley observed from ground between October 1985 and June 1986. The results to be presented include analysis of dust features as well as gas (CN) features in the coma and comparisons will be made between their spatial and temporal evolution. About 80 CN images and 300 continuum images from the Small Bodies Node of the NASA Planetary Data System were analyzed using image enhancement techniques that were not available n the 1980s. This enables us to see coma structure never observed before in comet 1P/Halley. Because of the comet's proximity to Earth, most of our best signal-to-noise images were taken in the March-April interval of 1986. Despite the limited coverage of preceding and following months, there is a sufficient number of images to monitor morphological evolution over many months. The initial synodic periods as a function of time used to phase the images together were extrapolated from the lightcurves of the active coma (Schleicher et al. 1990, AJ, 100, 896-912). We will present the periods of repeatability of individual coma features measured using the position angle at different spatial distances from the nucleus in adjacent cycles. Separate features appear to have slightly different periods of repeatability, perhaps depending on the corresponding source regions on the nucleus and/or projection effects. The periods of repeatability of coma morphologies will be presented as a function of time from the perihelion. These results will ultimately be used in detailed modeling of the coma morphologies of comet 1P/Halley over the 1985-1986 apparition in

  3. Effect of auditory stimulation on traumatic coma duration in intensive care unit of Medical Sciences University of Mazandarn, Iran

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Heidari Gorji

    2014-01-01

    Full Text Available Background: Sensory deprivation is one of the common complications of coma patients in the intensive care unit (ICU. The purpose of this study was to investigate the impact of a familiar voice to consciousness level in coma patients. Methods: A total of 13 patients with traumatic coma (8 ≥ Glasgow′s coma scale [GCS] admitted in ICU ward were randomly assigned to control and experimental groups. The experimental group was treated twice a daily each time 15 min with a familiar recorded MP3 sound for 2 weeks. The control group received only natural voices of environment. GCS applied to evaluate patients′ level of consciousness. Finding: Findings showed that duration to reach GCS = 15 was significantly shorter in the experimental group (χ 2 = 12/96, P < 0/001. Conclusion: These findings imply that providing familiar auditory stimulation programs for coma patients in the ICU could be effective.

  4. 低血糖昏迷42例临床分析%The Clinical Analysis of 42 Cases Patients with Hypoglycemic Coma

    Institute of Scientific and Technical Information of China (English)

    秦淑兰; 张美英; 李志平; 张笠; 赖晓阳

    2009-01-01

    Objective To investigate the causes and clinical features in patients with hypoglycemic coma.Methods A total of 42 patients with hypoglycemic coma were analyzed retrospectively.Results Elderly patients had the high incidence (69.0%,29/42) of hypoglycemic coma.There was 83.3%(35/42) of patients suffered from diabetes mellitus,and most of them were due to an irrational treatment with drugs.16.7%(7/42) patients is non-diabetes mellitus patient,including 2 patients suffered from Sheehan syndrome and 2 from alcoholic hypoglycemia.40 patients with hypoglycemic were able to obtain effective therapy in the early phase of coma.Conclusion We should carry out more educations for patients to prevent the incidence of hypoglycemia,especially for elderly patients. Blood glucose examination should be warranted for comatose patients,in order to obtain the correct diagnosis quickly.%目的 探讨低血糖昏迷患者的病因及临床特点.方法 对42例低血糖昏迷患者的临床资料进行回顾性分析.结果 老年患者容易发生低血糖昏迷,占69.0%(29/42);糖尿病低血糖昏迷占83.3%(35/42),病因以用药不当为主;非糖尿病低血糖昏迷占16.7%(7/42),包括2例席汉氏综合征及2例酒精性低血糖.40例低血糖昏迷患者早期治疗效果良好.结论 应加强预防低血糖的知识宣传,特别是针对老年人.建议将血糖检测作为昏迷患者的常规检测项目,以利于快速确立正确诊断.

  5. Acidosis y coma en el Diabético

    Directory of Open Access Journals (Sweden)

    Alfredo Jácome Roca

    1992-12-01

    Full Text Available

    Definición. La cetoacidosis diabética (CADy la alcohólica, la acidosis láctica y el síndrome hiperosmolar hiperglucémico (SHH a menudo se sobreponen en grado considerable, por lo que los revisaremos en conjunto. Definiremos la cetoacidosLs diabética como la descompensación grave de la diabetes, la emergencia endocrina más común caracterizada por un desequilibrio ácido-básico, de líquidos y electrolitos, asociado a una diuresis osmótica y catabolismo de las grasas por hiperglucemia insulino- deficiente.

    El síndrome hiperosmolar hiperglucémico es de comienzo lento y se caracteriza por trastorno del estado de conciencia, deshidratación profunda e hiperglucemia sin cetoacidosis. La cetoacidosLs alcohólica es un desequilibrio ácido-básico con deshidratación en alcohólicos, mujeres por lo común, no necesariamente diabéticas, aunque puede haber moderada hiperglucemia. La acidos Ls láctica puede ser complicación de un estado de shock y/o deshidratación severa, o de ingesta abundante de alcohol, lo que también puede llevar a hiperuricemia y gota.

    Signos y síntomas. Malestar general, astenia, anorexia, náusea, vómito, dolor abdominal con somnolencia, estupor y/o coma, pueden ser manifestaciones de cualquiera de las entidades arriba mencionadas.

    Sin embargo, aunque tanto en CADcomo en SHH hay signos de deshidratación (sequedad de mucosa con piel seca sin turgencia, ojos hundidos, en el primero hay náusea, vómito y respiración acidótica (rápida y profunda, lo que generalmente falta en el segundo. ElCADes de niños y adultos jóvenes o maduros, con función cardio-renal aceptable mientras que el SHHes más de ancianos, a menudo hipertensos con fallas renal o cardíaca, hemiparéticos, que pueden consultar por convulsiones focales. No siempre el paciente es reconocido como diabético, sobre todo en SHH.

    Lapoliuria y la polidipsia caracterizan a la acidosis diabética y al s

  6. Extended Radio Sources and the Diffuse Medium in the Coma / A1367 Supercluster

    NARCIS (Netherlands)

    Jaffe, W. J.; Gavazzi, G.; Valentijn, E. A.

    1984-01-01

    Studies of extended, thermally confined radio sources in rich clusters provided estimates of the pressure and temperature in the cluster medium that confirmed the values obtained from X-ray studies. The authors have now found some extended sources in the Coma-A1367 supercluster that may yield simila

  7. The entropy of elliptical galaxies in Coma a clue for a distance indicator

    CERN Document Server

    Gerbal, D; Márquez, I; Verhagen, H; Gerbal, Daniel; Neto, Gastao B. Lima; Marquez, Isabel; Verhagen, Huub

    1997-01-01

    We have fitted the surface brightness of a sample of 79 elliptical galaxies pertaining to the Coma cluster of galaxies using the Sersic profile. This model is defined through three primary parameters: scale length (a), intensity ($\\Sigma_0$), and a shape parameter (\

  8. U-, B- and r-band luminosity functions of galaxies in the Coma cluster

    NARCIS (Netherlands)

    Beijersbergen, M; Hoekstra, H; van Dokkum, PG; van der Hulst, T

    2002-01-01

    We present a deep multicolour CCD mosaic of the Coma cluster (Abell 1656), covering 5.2 deg(2) in the B and r bands, and 1.3 deg(2) in the U band. This large, homogeneous data set provides a valuable low-redshift comparison sample for studies of galaxies in distant clusters. In this paper we present

  9. Morfología de la Coma del Cometa Hale - Bopp

    Science.gov (United States)

    Gil-Hutton, R.; Caballero, M.; Coldwell, G.; Cañada, M.; Godoy, G.; Trozzo, C.; Gómez, G.

    Para lograr comprender plenamente los procesos físicos que se desarrollan en los núcleos cometarios y obtener un modelo que explique, no sólo su actividad, sino también sus efectos sobre la coma, es necesario obtener información detallada para el mayor número de cometas posible, siendo las características más interesantes para estudiar la ubicación de las regiones activas, la presencia de jets, las tasas de producción de gas y polvo y la interacción de la coma con el viento solar. En la actualidad, con técnicas de procesamiento de imágenes y tecnología CCD se pueden obtener este tipo de datos para cometas que ingresan al sistema solar interior y estudiar, de esta manera, la morfología de sus comas, tratando de correlacionar la actividad detectada con algún modelo teórico. En este trabajo se presenta un estudio parcial de la actividad desarrollada por el cometa Hale-Bopp, y sus efectos sobre la morfología de su coma, desde agosto de 1995 hasta la fecha en base a imágenes adquiridas con el telescopio de 0.76 m. de la Estación Astronómica Dr. Carlos Ulrrico Cesco.

  10. The HST/ACS Coma Cluster Survey : II. Data Description and Source Catalogs

    NARCIS (Netherlands)

    Hammer, Derek; Kleijn, Gijs Verdoes; Hoyos, Carlos; den Brok, Mark; Balcells, Marc; Ferguson, Henry C.; Goudfrooij, Paul; Carter, David; Guzman, Rafael; Peletier, Reynier F.; Smith, Russell J.; Graham, Alister W.; Trentham, Neil; Peng, Eric; Puzia, Thomas H.; Lucey, John R.; Jogee, Shardha; Aguerri, Alfonso L.; Batcheldor, Dan; Bridges, Terry J.; Chiboucas, Kristin; Davies, Jonathan I.; del Burgo, Carlos; Erwin, Peter; Hornschemeier, Ann; Hudson, Michael J.; Huxor, Avon; Jenkins, Leigh; Karick, Arna; Khosroshahi, Habib; Kourkchi, Ehsan; Komiyama, Yutaka; Lotz, Jennifer; Marzke, Ronald O.; Marinova, Irina; Matkovic, Ana; Merritt, David; Miller, Bryan W.; Miller, Neal A.; Mobasher, Bahram; Mouhcine, Mustapha; Okamura, Sadanori; Percival, Sue; Phillipps, Steven; Poggianti, Bianca M.; Price, James; Sharples, Ray M.; Tully, R. Brent; Valentijn, Edwin

    2010-01-01

    The Coma cluster, Abell 1656, was the target of an HST-ACS Treasury program designed for deep imaging in the F475W and F814W passbands. Although our survey was interrupted by the ACS instrument failure in early 2007, the partially completed survey still covers ~50% of the core high-density region in

  11. The HST/ACS Coma Cluster Survey. II. Data Description and Source Catalogs

    NARCIS (Netherlands)

    Hammer, Derek; Verdoes Kleijn, Gijs; Hoyos, Carlos; den Brok, Mark; Balcells, Marc; Ferguson, Henry C.; Goudfrooij, Paul; Carter, David; Guzmán, Rafael; Peletier, Reynier F.; Smith, Russell J.; Graham, Alister W.; Trentham, Neil; Peng, Eric; Puzia, Thomas H.; Lucey, John R.; Jogee, Shardha; Aguerri, Alfonso L.; Batcheldor, Dan; Bridges, Terry J.; Chiboucas, Kristin; Davies, Jonathan I.; del Burgo, Carlos; Erwin, Peter; Hornschemeier, Ann; Hudson, Michael J.; Huxor, Avon; Jenkins, Leigh; Karick, Arna; Khosroshahi, Habib; Kourkchi, Ehsan; Komiyama, Yutaka; Lotz, Jennifer; Marzke, Ronald O.; Marinova, Irina; Matkovic, Ana; Merritt, David; Miller, Bryan W.; Miller, Neal A.; Mobasher, Bahram; Mouhcine, Mustapha; Okamura, Sadanori; Percival, Sue; Phillipps, Steven; Poggianti, Bianca M.; Price, James; Sharples, Ray M.; Tully, R. Brent; Valentijn, Edwin

    2010-01-01

    The Coma cluster, Abell 1656, was the target of an HST-ACS Treasury program designed for deep imaging in the F475W and F814W passbands. Although our survey was interrupted by the ACS instrument failure in early 2007, the partially completed survey still covers ~50% of the core high-density region in

  12. Evaluation of the traumatic coma data bank computed tomography classification for severe head injury

    NARCIS (Netherlands)

    Vos, P E; van Voskuilen, A C; Beems, T; Krabbe, P F; Vogels, O J

    2004-01-01

    This study determines the interrater and intrarater reliability of the Traumatic Coma Data Bank (TCDB) computed tomography (CT) scan classification for severe head injury. This classification grades the severity of the injury as follows: I = normal, II = diffuse injury, III = diffuse injury with swe

  13. Planck intermediate results. X. Physics of the hot gas in the Coma cluster

    NARCIS (Netherlands)

    Planck Collaboration, [No Value; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Baccigalupi, C.; Balbi, A.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Battaner, E.; Benabed, K.; Benoît, A.; Bernard, J.-P.; Bersanelli, M.; Bikmaev, I.; Böhringer, H.; Bonaldi, A.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bourdin, H.; Brown, M. L.; Brown, S. D.; Burenin, R.; Burigana, C.; Cabella, P.; Cardoso, J.-F.; Carvalho, P.; Catalano, A.; Cayón, L.; Chiang, L.-Y.; Chon, G.; Christensen, P. R.; Churazov, E.; Clements, D. L.; Colafrancesco, S.; Colombo, L. P. L.; Coulais, A.; Crill, B. P.; Cuttaia, F.; Da Silva, A.; Dahle, H.; Danese, L.; Davis, R. J.; de Bernardis, P.; de Gasperis, G.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Démoclès, J.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Dörl, U.; Douspis, M.; Dupac, X.; Enßlin, T. A.; Eriksen, H. K.; Finelli, F.; Flores-Cacho, I.; Forni, O.; Frailis, M.; Franceschi, E.; Frommert, M.; Galeotta, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; Gilfanov, M.; González-Nuevo, J.; Górski, K. M.; Gregorio, A.; Gruppuso, A.; Hansen, F. K.; Harrison, D.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, T. R.; Jagemann, T.; Jones, W. C.; Juvela, M.; Keihänen, E.; Khamitov, I.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lawrence, C. R.; Le Jeune, M.; Leonardi, R.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maffei, B.; Maino, D.; Mandolesi, N.; Maris, M.; Marleau, F.; Martínez-González, E.; Masi, S.; Massardi, M.; Matarrese, S.; Matthai, F.; Mazzotta, P.; Mei, S.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Natoli, P.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Osborne, S.; Pajot, F.; Paoletti, D.; Perdereau, O.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Piffaretti, R.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G. W.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Roman, M.; Rosset, C.; Rossetti, M.; Rubiño-Martín, J. A.; Rudnick, L.; Rusholme, B.; Sandri, M.; Savini, G.; Schaefer, B. M.; Scott, D.; Smoot, G. F.; Stivoli, F.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tuovinen, J.; Türler, M.; Umana, G.; Valenziano, L.; Van Tent, B.; Varis, J.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L. A.; Wandelt, B. D.; Welikala, N.; White, S. D. M.; Yvon, D.; Zacchei, A.; Zaroubi, S.; Zonca, A.

    2013-01-01

    We present an analysis of Planck satellite data on the Coma cluster observed via the Sunyaev-Zeldovich effect. Thanks to its great sensitivity, Planck is able, for the first time, to detect SZ emission up to r ≈ 3 × R500. We test previously proposed spherically symmetric models for the pressure dist

  14. Coma and death in unrecognized wernicke's encephalopathy an autopsy study: estudo necroscópico

    Directory of Open Access Journals (Sweden)

    Marco Aurélio Lana-peixoto

    1992-09-01

    Full Text Available Eleven out of 36 autopsied cases of Wernicke's encephalopathy had developed coma. None of these patients had the diagnosis during life. There were six men and five women with ages ranging from 36 to 50 years (mean 36.6. Seven of these patients were heavy drinkers, three exhibited signs of severe malnutrition, whereas one was being evaluated for a disseminated gastric cancer and one was in treatment of hyperemesis gravidarum. Two patients were brought to the hospital after found unconscious at home. Neuropatholo-gical examination disclosed gross changes in the mammillary bodies in eight cases and microscopic changes in all cases. In one case there was atrophy of the anterior superior part of the vermis. Petechial hemorrhages were observed particularly in the walls of the third ventricle. Microscopically there were in addition to hemorrhages, glial proliferation, endothelial hypertrophy and necrosis of nerve cells and myelin. Central pontine myelmolysis was observed in one case. Wernicke's encephalopathy is a clinically underdiagnosed condition. Coma may mask its classical clinical picture or even be the sole manifestation. Although coma points to a poor outlook it may be reversed by thiamine administration. Any patient with Coma of unknown etiology should be given parenteral thiamine.

  15. Globular Clusters and Spur Clusters in NGC 4921, the Brightest Spiral Galaxy in the Coma Cluster

    CERN Document Server

    Lee, Myung Gyoon

    2016-01-01

    We resolve a significant fraction of globular clusters (GCs) in NGC 4921, the brightest spiral galaxy in Coma. Also we find a number of extended bright star clusters (star complexes) in the spur region of the arms. The latter are much brighter and bluer than those in the normal star-forming region, being as massive as 3x10^5 M_odot. The color distribution of the GCs in this galaxy is found to be bimodal. The turnover magnitudes of the luminosity functions (LF) of the blue (metal-poor) GCs (0.70<(V-I)<1.05) in the halo are estimated to be V(max) =27.11+-0.09 mag and I(max)=26.21+-0.11 mag. We obtain similar values for NGC 4923, a companion S0 galaxy, and two Coma cD galaxies (NGC 4874 and NGC 4889). The mean value for the turnover magnitudes of these four galaxies is I(max)=26.25+-0.03 mag. Adopting M_I (max) = -8.56+-0.09 mag for the metal-poor GCs, we determine the mean distance to the four Coma galaxies, 91+-4 Mpc. Combining this and the Coma radial velocity, we derive a value of the Hubble constant, ...

  16. Spatial variation in automated burst suppression detection in pharmacologically induced coma.

    Science.gov (United States)

    An, Jingzhi; Jonnalagadda, Durga; Moura, Valdery; Purdon, Patrick L; Brown, Emery N; Westover, M Brandon

    2015-01-01

    Burst suppression is actively studied as a control signal to guide anesthetic dosing in patients undergoing medically induced coma. The ability to automatically identify periods of EEG suppression and compactly summarize the depth of coma using the burst suppression probability (BSP) is crucial to effective and safe monitoring and control of medical coma. Current literature however does not explicitly account for the potential variation in burst suppression parameters across different scalp locations. In this study we analyzed standard 19-channel EEG recordings from 8 patients with refractory status epilepticus who underwent pharmacologically induced burst suppression as medical treatment for refractory seizures. We found that although burst suppression is generally considered a global phenomenon, BSP obtained using a previously validated algorithm varies systematically across different channels. A global representation of information from individual channels is proposed that takes into account the burst suppression characteristics recorded at multiple electrodes. BSP computed from this representative burst suppression pattern may be more resilient to noise and a better representation of the brain state of patients. Multichannel data integration may enhance the reliability of estimates of the depth of medical coma.

  17. Results from the Worldwide Coma Morphology Campaign for Comet ISON (C/2012 S1)

    CERN Document Server

    Samarasinha, Nalin H

    2015-01-01

    We present the results of a global coma morphology campaign for comet C/2012 S1 (ISON), which was organized to involve both professional and amateur observers. In response to the campaign, many hundreds of images, from nearly two dozen groups were collected. Images were taken primarily in the continuum, which help to characterize the behavior of dust in the coma of comet ISON. The campaign received images from January 12 through November 22, 2013 (an interval over which the heliocentric distance decreased from 5.1 AU to 0.35 AU), allowing monitoring of the long-term evolution of coma morphology during the pre-perihelion leg of comet ISON. Data were contributed by observers spread around the world, resulting in particularly good temporal coverage during November when comet ISON was brightest but its visibility was limited from any one location due to the small solar elongation. We analyze the northwestern sunward continuum coma feature observed in comet ISON during the first half of 2013, finding that it was l...

  18. Prospective Cohort Study Evaluating the Prognostic Value of Simple EEG Parameters in Postanoxic Coma.

    Science.gov (United States)

    Azabou, Eric; Fischer, Catherine; Mauguiere, François; Vaugier, Isabelle; Annane, Djillali; Sharshar, Tarek; Lofaso, Fréderic

    2016-01-01

    We prospectively studied early bedside standard EEG characteristics in 61 acute postanoxic coma patients. Five simple EEG features, namely, isoelectric, discontinuous, nonreactive to intense auditory and nociceptive stimuli, dominant delta frequency, and occurrence of paroxysms were classified yes or no. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the receiver operating characteristic curve (AUC) of each of these variables for predicting an unfavorable outcome, defined as death, persistent vegetative state, minimally conscious state, or severe neurological disability, as assessed 1 year after coma onset were computed as well as Synek's score. The outcome was unfavorable in 56 (91.8%) patients. Sensitivity, specificity, PPV, NPV, and AUC of nonreactive EEG for predicting an unfavorable outcome were 84%, 80%, 98%, 31%, and 0.82, respectively; and were all very close to the ones of Synek score>3, which were 82%, 80%, 98%, 29%, and 0.81, respectively. Specificities for predicting an unfavorable outcome were 100% for isoelectric, discontinuous, or dominant delta activity EEG. These 3 last features were constantly associated to unfavorable outcome. Absent EEG reactivity strongly predicted an unfavorable outcome in postanoxic coma, and performed as accurate as a Synek score>3. Analyzing characteristics of some simple EEG features may easily help nonneurophysiologist physicians to investigate prognostic issue of postanoxic coma patient. In this study (a) discontinuous, isoelectric, or delta-dominant EEG were constantly associated with unfavorable outcome and (b) nonreactive EEG performed prognostic as accurate as a Synek score>3.

  19. H-ATLAS: The Far-Infrared properties of galaxies in and around the Coma Cluster

    CERN Document Server

    Fuller, C; Smith, M W L; Valiante, E; Eales, S; Bourne, N; Dunne, L; Dye, S; Furlanetto, C; Ibar, E; Ivison, R; Maddox, S; Sansom, A; Michalowski, M J; Davis, T

    2016-01-01

    We describe a far infrared survey of the Coma cluster and the galaxy filament it resides within. Our survey covers an area of $\\sim$150 deg$^2$ observed by $Herschel$ H-ATLAS in five bands at 100, 160, 250, 350 and 500$\\mu$m. The SDSS spectroscopic survey ($m_{r} \\le 17.8)$ is used to define an area (within the Virial radius) and redshift selected ($4268 < v < 9700$ km s$^{-1}$) sample of 744 Coma cluster galaxies - the Coma Cluster Catalogue (CCC). For comparison we also define a sample of 951 galaxies in the connecting filament - the Coma Filament Catalogue (CFC). The optical positions and parameters are used to define appropriate apertures to measure each galaxy's far infrared emission. We have detected 99 of 744 (13\\%) and 422 of 951 (44\\%) of the cluster and filament galaxies in the SPIRE 250$\\mu$m band. We consider the relative detection rates of galaxies of different morphological types finding that it is only the S0/Sa population that shows clear differences between the cluster and filament. We ...

  20. Communication Opportunities via Special Messaging Technology for Two Post-Coma Persons with Multiple Disabilities

    Science.gov (United States)

    Lancioni, Giulio E.; O'Reilly, Mark F.; Singh, Nirbhay N.; Sigafoos, Jeff; Buonocunto, Francesca; Sacco, Valentina; Colonna, Fabio; Navarro, Jorge; Lanzilotti, Crocifissa; de Pace, Claudia; Megna, Marisa; Oliva, Doretta

    2011-01-01

    This study extended the assessment of a special messaging technology with two additional post-coma adults who had emerged from a minimally conscious state, but showed multiple disabilities including profound motor and communication impairments. For each participant, the study involved an ABAB design, in which the A represented baseline phases and…

  1. How does information influence hope in family members of traumatic coma patients in intensive care unit?

    NARCIS (Netherlands)

    Verhaeghe, S.T.L.; Zuuren, F.J. van; Defloor, T.; Duijnstee, M.S.H.; Grypdonck, M.H.F.

    2007-01-01

    AIMS: To assess the interplay between hope and the information provided by health care professionals. BACKGROUND: Earlier research learned that hope is crucial for relatives of traumatic coma patients. Also it has been reported that the need for information is extremely important for relatives of c

  2. Planck intermediate results : X. Physics of the hot gas in the Coma cluster

    NARCIS (Netherlands)

    Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Baccigalupi, C.; Balbi, A.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Battaner, E.; Benabed, K.; Benoit, A.; Bernard, J. -P.; Bersanelli, M.; Bikmaev, I.; Boehringer, H.; Bonaldi, A.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bourdin, H.; Brown, M. L.; Brown, S. D.; Burenin, R.; Burigana, C.; Cabella, P.; Cardoso, J. -F.; Carvalho, P.; Catalano, A.; Cayon, L.; Chiang, L. -Y; Chon, G.; Christensen, P. R.; Churazov, E.; Clements, D. L.; Colafrancesco, S.; Colombo, L. P. L.; Coulais, A.; Crill, B. P.; Cuttaia, F.; Da Silva, A.; Dahle, H.; Danese, L.; Davis, R. J.; de Bernardis, P.; de Gasperis, G.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Democles, J.; Desert, F. -X.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Dore, O.; Doerl, U.; Douspis, M.; Dupac, X.; Ensslin, T. A.; Eriksen, H. K.; Finelli, F.; Flores-Cacho, I.; Forni, O.; Frailis, M.; Franceschi, E.; Frommert, M.; Galeotta, S.; Ganga, K.; Genova-Santos, R. T.; Giard, M.; Gilfanov, M.; Gonzalez-Nuevo, J.; Gorski, K. M.; Gregorio, A.; Gruppuso, A.; Hansen, F. K.; Harrison, D.; Henrot-Versille, S.; Hernandez-Monteagudo, C.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, T. R.; Jagemann, T.; Jones, W. C.; Juvela, M.; Keihanen, E.; Khamitov, I.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lahteenmaki, A.; Lamarre, J. -M.; Lasenby, A.; Lawrence, C. R.; Le Jeune, M.; Leonardi, R.; Lilje, P. B.; Linden-Vornle, M.; Lopez-Caniego, M.; Lubin, P. M.; Macias-Perez, J. F.; Maffei, B.; Maino, D.; Mandolesi, N.; Maris, M.; Marleau, F.; Martinez-Gonzalez, E.; Masi, S.; Massardi, M.; Matarrese, S.; Matthai, F.; Mazzotta, P.; Mei, S.; Melchiorri, A.; Melin, J. -B.; Mendes, L.; Mennella, A.; Mitra, S.; Miville-Deschenes, M. -A.; Moneti, A.; Montier, L.; Morgante, G.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Natoli, P.; Norgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Osborne, S.; Pajot, F.; Paoletti, D.; Perdereau, O.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Piffaretti, R.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G. W.; Prunet, S.; Puget, J. -L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Roman, M.; Rosset, C.; Rossetti, M.; Rubino-Martin, J. A.; Rudnick, L.; Rusholme, B.; Sandri, M.; Savini, G.; Schaefer, B. M.; Scott, D.; Smoot, G. F.; Stivoli, F.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A. -S.; Sygnet, J. -F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tuovinen, J.; Tuerler, M.; Umana, G.; Valenziano, L.; Van Tent, B.; Varis, J.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L. A.; Wandelt, B. D.; Welikala, N.; White, S. D. M.; Yvon, D.; Zacchei, A.; Zaroubi, S.; Zonca, A.

    2013-01-01

    We present an analysis of Planck satellite data on the Coma cluster observed via the Sunyaev-Zeldovich effect. Thanks to its great sensitivity, Planck is able, for the first time, to detect SZ emission up to r approximate to 3 x R-500. We test previously proposed spherically symmetric models for the

  3. Transient Coma Due To Epidural Anesthesia: The Role of Loss of Sensory Input.

    LENUS (Irish Health Repository)

    Dardis, Christopher

    2015-12-21

    Epidural anesthesia is the most commonly used method of pain relief during labor in the USA. It is not classically associated with alterations in level of alertness. Coma during the procedure is rare, with a reported incidence of 0.1-0.3%.

  4. A turn-over in the galaxy luminosity function of the coma cluster core?

    CERN Document Server

    Adami, C; Durret, F; Nichol, R C; Mazure, A; Holden, B P; Romer, A K; Savine, C

    2000-01-01

    Our previous study of the faint end (R$\\leq$21.5) of the galaxy luminosity function (GLF) was based on spectroscopic data in a small region near the Coma cluster center. In this previous study Adami et al. (1998) suggested, with moderate statistical significance, that the number of galaxies actually belonging to the cluster was much smaller than expected. This led us to increase our spectroscopic sample. Here, we have improved the statistical significance of the results of the Coma GLF faint end study (R$\\leq$22.5) by using a sample of 85 redshifts. This includes both new spectroscopic data and a literature compilation. The relatively small number of faint galaxies belonging to Coma that was suggested by Adami et al. (1998) and Secker et al. (1998) has been confirmed with these new observations. We also confirm that the color-magnitude relation is not well suited for finding the galaxies inside the Coma cluster core, close to the center at magnitudes fainter than R$\\sim$19. We show that there is an enhancemen...

  5. Acute isoniazid intoxication: an uncommon cause of convulsion, coma and acidosis.

    Science.gov (United States)

    Uzman, Sinan; Uludağ Yanaral, Tümay; Toptaş, Mehmet; Koç, Alparslan; Taş, Aytül; Bican, Gülşen

    2013-01-01

    Despite the widespread use, suicidal ingestion of isoniazid is a rare condition in Turkey. We reported a case of acute isoniazid intoxication associated with alcohol intake presenting with convulsion, coma and metabolic acidosis. The patient was treated successfully with intravenous pyridoxine administration. Early recognation and appropriate treatment in the intensive care unit is very important to prevent mortality in patients with acute isoniazid toxicity.

  6. The etiology and outcome of non-traumatic coma in critical care: a systematic review

    NARCIS (Netherlands)

    Horsting, Marlene Wb B; Franken, Mira D; Meulenbelt, Jan; van Klei, Wilton A; de Lange, Dylan W

    2015-01-01

    BACKGROUND: Non-traumatic coma (NTC) is a serious condition requiring swift medical or surgical decision making upon arrival at the emergency department. Knowledge of the most frequent etiologies of NTC and associated mortality might improve the management of these patients. Here, we present the res

  7. The etiology and outcome of non-traumatic coma in critical care : A systematic review

    NARCIS (Netherlands)

    Horsting, Marlene WB; Franken, Mira D.; Meulenbelt, Jan; van Klei, Wilton A.; de Lange, Dylan W.

    2015-01-01

    Background: Non-traumatic coma (NTC) is a serious condition requiring swift medical or surgical decision making upon arrival at the emergency department. Knowledge of the most frequent etiologies of NTC and associated mortality might improve the management of these patients. Here, we present the res

  8. Role of noradrenaline in wake promotion effect of orexin-A on alcohol coma in rats

    Directory of Open Access Journals (Sweden)

    Tian-hao WANG

    2013-02-01

    Full Text Available Objective  To study whether or not noradrenaline system participates in the process of orexin-A wake-promoting from alcohol coma. Methods  Twenty-four adult female SPF SD rats were divided into four groups, 6 each, and the model of alcohol coma was reproduced. Experimental rats were then divided randomly into rats receiving injection of artificial cerebrospinal fluid (ACSF, control group, orexin-A (orexin-A group, noradrenaline α1 receptor antagonists--prazosin (prazosin group, or prazosin + orexin-A (prazosin-orexin-A group into the lateral ventricle. The depth of coma was evaluated by the duration of loss of righting reflex (LORR and δ wave in electrocorticogram (ECoG. Results  The duration of LORR was significantly longer and the ratio of δ wave higher in the prazosin-treated rats than those in control group (P0.05. But the values were significantly different from those in the orexin-A group (P<0.01. Conclusion  Noradrenaline system may participate in the wake-promoting process of alcohol coma by orexin-A.

  9. ["Shock" therapies in Nazi Germany. The example of Berlin psychiatry].

    Science.gov (United States)

    Rzesnitzek, L

    2014-09-01

    The idea that "shock" therapies were introduced by "Nazi-Psychiatry" very early and used radically in a cruel way darkens the image of these therapies until today. A case analysis of patient files of psychiatric hospitals in Berlin is used to recapitulate the introduction of insulin coma, metrazol and electroconvulsive therapy during the National Socialism era. Contrary to the false assumption that these "shock" therapies would have been introduced and preferred by psychiatrists involved with the Nazi regime and "euthanasia", in the case of Berlin these therapies were delayed by them and seldom used.

  10. Etiology and Outcome of Non-Traumatic Coma in Children Admitted to Pediatric Intensive Care Unit

    Directory of Open Access Journals (Sweden)

    Fariba Khodapanahandeh

    2009-12-01

    Full Text Available Objective: Non-traumatic coma is a relatively common condition in children that may cause considerable mortality and morbidity. The purpose of this study was to determine clinical presentation, etiology and outcome of non-traumatic coma in children.Methods: In a retrospective cross sectional study over a period of 5 years, files of 150 children aged between 1 month and 14 years admitted with non-traumatic coma to pediatric intensive care unit of Rasool Akram hospital were reviewed. Historical, presenting symptoms, clinical and laboratory data were collected. Etiology of coma was determined on the basis of clinical history and relevant investigations. The outcome was recorded as died or neurological condition at discharge as normal, mild or sever disability. Chi-square test was used to test the differences in categorical variables.Findings: There were 63 (42% boys and 87 (58% girls. The mean±SD age of patients was 2.7±2.35 years. Systemic presentations including nausea, vomiting, fever, lethargy and poor feeding were more prominent in children under 2 years. Etiology of coma in 49 patients (32.7% was infectious (meningitis, encephalitis, respiratory and systemic. Other causes were status epilepticus 44 (29.4%, metabolic (diabetic ketoacidosis, inborn errors of metabolism 11 (7.3%, intoxications 10 (6.7%, accidental (drowning, electrical shock, suffocation 9 (6%, shunt dysfunction (secondary to congenital brain malformations 7 (4.6%, others (acute disseminated encephalomyelitis, vasculitis, hypertensive encephalopathy 11 (7.3%, unknown 9 (6%. Infection occurred significantly (P=0.002 in children under 2 years of age, whereas accidents and intoxications were more prominent (P=0.004 in those between 2 and 6 years. Overall 25 children (16.6% died. Of those survived 16 became severely disabled. Accidents and infections had higher mortality compared to other groups (P<0.001 and P=0.02 respectively.Conclusion: Our results showed that infection was the

  11. Ogilvie′s syndrome in a case of myxedema coma

    Directory of Open Access Journals (Sweden)

    Uday Yanamandra

    2012-01-01

    Full Text Available Ogilvie′s syndrome [acute colonic pseudo-obstruction (ACPO] presents as massive colonic dilatation without a mechanical cause, usually in critically ill patients due to imbalanced sympathetic and parasympathetic activity. The initial therapy remains conservative with supportive measures (correction of metabolic, infectious or pharmacologic factors followed by neostigmine and decompressive colonoscopy. Surgery is reserved for patients with clinical deterioration or with evidence of colonic ischemia or perforation. A 60-year-old lady presented with fever, altered sensorium, obstipation, bradycardia and abdominal distension. Investigation revealed hyponatremia and acute colonic pseudo-obstruction. Supportive measures and decompressive colonoscopy were not of great benefit. Thyroid profile was suggestive of primary hypothyroidism. Colonic motility was restored only on starting thyroxin. The case is illustrative of the need to consider hypothyroidism, a common endocrine disorder, in the differential diagnosis of Ogilvie′s.

  12. Early blindness and coma during intrathecal chemotherapy for meningeal carcinomatosis.

    Science.gov (United States)

    Boogerd, W; Moffie, D; Smets, L A

    1990-02-01

    A 35-year-old woman was treated with intraventricular methotrexate (MTX) with a total dose of 70 mg followed by cytosine arabinoside (Ara-C) with a total dose of 80 mg for meningeal metastasis of breast carcinoma. Radiation therapy was not given. Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks. Postmortem examination revealed only minimal neoplastic infiltration of the meninges. Multiple foci of axonal degeneration and demyelination were found in the optic nerves and chiasm, the superficial layers of the brainstem, and spinal cord and to some extent in other cranial nerves and spinal nerve roots. The possible causes of this previously unreported early complication are discussed.

  13. Artificial selection on chill-coma recovery time in Drosophila melanogaster: Direct and correlated responses to selection.

    Science.gov (United States)

    Gerken, Alison R; Mackay, Trudy F C; Morgan, Theodore J

    2016-07-01

    Artificial selection can be used to create populations with extreme phenotypic responses to environmental stressors. When artificial selection is applied to a single component of a stress response, this selection may result in correlated responses in other stress responses, a phenomenon called cross-tolerance, which is ultimately controlled by the genetic correlations among traits. We selected for extreme responses to cold tolerance by selecting for chill-coma recovery time from a single temperate population of Drosophila melanogaster. Chill-coma recovery time is a common metric of low, but non-lethal, cold temperature tolerance. Replicated divergent artificial selection was applied to a genetically variable base population for 31 generations, resulting in two cold resistant, two cold susceptible, and two unselected control lines. To quantify the relationship between selection on chill-coma recovery and other metrics of thermal performance, we also measured survivorship after acute cold exposure, survivorship after chronic cold exposure, survivorship after cold exposure following a pre-treatment period (rapid cold hardening), starvation tolerance, and heat tolerance. We find that chill-coma recovery time is heritable within this population and that there is an asymmetric response to increased and decreased chill-coma recovery time. Surprisingly, we found no cross-tolerances between selection on chill-coma recovery time and the other environmental stress response traits. These results suggest that although artificial selection has dramatically altered chill-coma recovery time, the correlated response to selection on other stress response phenotypes has been negligible. The lack of a correlated response suggests that chill-coma recovery time in these selection lines is likely genetically independent from measures of cold survivorship tested here.

  14. Beyond S\\'ersic + exponential disc morphologies in the Coma Cluster

    CERN Document Server

    Head, Jacob T C G; Hudson, Michael J

    2015-01-01

    [abridged] We explore the diversity of internal galaxy structures in the Coma cluster across a wide range of luminosities ($-17$\\,$>$\\,$M_g$\\,$>$\\,$-22$) and cluster-centric radii ($0$\\,$ 10$ kpc). 11\\% of galaxies ($N=52$) feature a break in their outer profiles, indicating `truncated' or `anti-truncated' discs. Beyond the break radius, truncated galaxies are structurally consistent with exponential discs, disfavouring physical truncation as their formation mechanism. Bulge luminosity in anti-truncated galaxies correlates strongly with galaxy luminosity, indicating a bulge-enhancing origin for these systems. Both types of broken disc are found overwhelmingly ($>70\\%$) in `barred' galaxies, despite a low measured bar fraction for Coma ($20\\pm2\\%$). Thus, galaxy bars play an important role in formation of broken disc structures. No strong variation in galaxy structure is detected with projected cluster-centric radius.

  15. Observations Of The Egret Blazar W Comae With The Solar Tower Atmospheric Cherenkov Effect Experiment

    CERN Document Server

    Scalzo, R A

    2004-01-01

    The Solar Tower Atmospheric Cherenkov Effect Experiment (STACEE) is a wavefront-sampling atmospheric Cherenkov telescope which uses an array of solar heliostat mirrors as its primary optic. STACEE is designed to detect air showers from astrophysical gamma rays with energies between 50 and 250 GeV. Recent observations of the BL Lac object W Comae (ON+231), made in the spring of 2003 using STACEE, detect no significant gamma ray emission. The implications of this null result for the composition of the relativistic jet in W Comae is discussed, examining both leptonic and hadronic jet models from the literature. The 95% confidence level upper limit on the flux ranges from 1.5–3.5 × 10−10 cm−2 s−1 above 100 GeV for the leptonic models, and from 0.5–1.1 × 10−10 cm−2 s−1 above 150 GeV for the hadronic models.

  16. Internal energy flows of coma-affected singular beams in low-numerical-aperture systems.

    Science.gov (United States)

    Bahl, Monika; Singh, Brijesh Kumar; Singh, Rakesh Kumar; Senthilkumaran, P

    2015-04-01

    The circulating phase gradient component of a singular beam gets modified when focused by a low-numerical-aperature system suffering from coma aberration. The gradient due to this coma aberration splits the higher charge vortex into elementary vortices and distributes them spatially. This splitting depends on the charge and polarity of the incident singular beam as well as the sign and magnitude of the aberration coefficient. The transverse component of the Poynting vector field distribution at the focal plane is decomposed into the curl or solenoidal component and divergence or irrotational component using the Helmholtz-Hodge decomposition technique. The solenoidal component that relates to the orbital angular momentum carries the circulating energy, while the irrotational component shows the sources and sinks of the energy. Intriguing results of the study of energy flow around the edge dislocations apart from the point phase defects in the irrotational components are also presented.

  17. From clinical judgment to odds: a history of prognostication in anoxic-ischemic coma.

    Science.gov (United States)

    Wijdicks, Eelco F M

    2012-08-01

    Persistent coma from a major anoxic-ischemic injury to the brain may indicate there is less chance for full recovery. The tools of prognostication to assess comatose survivors of cardiopulmonary resuscitation have developed over several decades. Physicians would initially base their judgment on experience and data on outcome in these patients in the early years were merely on awakening not on disability. In the late 1970s, a large multicenter prospective study was performed on outcome in nontraumatic coma. The impetus for this study was the result of Plum and Jennet's collaboration. In 1981--for the first time--complex statistics were used to improve the accuracy of prognosis and became known as the "Levy algorithms." These early seminal studies shaped the prediction models and implied that clinical information alone could assist physicians in making a prediction. Later, probabilistic methods became more commonplace.

  18. The Colors and Stellar Populations of Ultra-Diffuse Galaxies in the Coma and Virgo Clusters

    Science.gov (United States)

    Babakhanyan Stone, Maria; Romanowsky, Aaron J.

    2017-01-01

    Ultra-diffuse galaxies (UDGs) were recently discovered both within and beyond galaxy clusters. UDGs have low luminosities, yet some can be as large as the Milky Way. Their evolutionary histories are unknown, with proposed explanations including “failed” giant galaxies, or dwarfs that were quenched through cluster infall. Here we study trends in color for UDGs in the Coma and Virgo clusters, with comparisons to normal galaxies. We also use stellar population models to estimate ages and metallicities of the UDGs.

  19. The Large-Grained Dust Coma of 174P/Echeclus

    Science.gov (United States)

    Bauer, James M.; Choi, Young-Jun; Weissman, Paul R.; Stansberry, John A.; Fernandez, Yanga R.; Roe, Henry G.; Buratti, Bonnie J.; Sung, Hyun-Il

    2008-01-01

    On 2005 December 30, Y.-J. Choi and P. R. Weissman discovered that the formerly dormant Centaur 2000 EC98 was in strong outburst. Previous observations by P. Rousselot et al. spanning a 3-year period indicated a lack of coma down to the 27 mag arcsec 2 level.We present Spitzer Space Telescope MIPS observations of this newly active Centaur--now known as 174P/Echeclus (2000 EC98)--or 60558 Echeclus--taken in 2006 late February. The images show strong signal at both the 24 and 70 micron bands and reveal an extended coma about 2' in diameter. Analyses yield estimates of the coma signal contribution that are in excess of 90% of the total signal in the 24 micron band. Dust production estimates ranging from 1.7-4 x 10(exp 2) kg/s are on the order of 30 times that seen in other Centaurs. Simultaneous visible-wavelength observations were also obtained with Palomar Observatory's 200-inch telescope, the 1.8-m Vatican Advanced Technology Telescope, the Bohyunsan Optical Astronomy Observatory (BOAO) 1.8-m telescope, and Table Mountain Observatory's 0.6-m telescope, revealing a coma morphology nearly identical to the mid-IR observations. The grain size distribution derived from the data yields a log particle mass power-law with slope parameter (alpha) = -0.87 +/- 0.07, and is consistent with steady cometary-activity, such as that observed during the Stardust spacecraft's encounter at 81P/Wild 2, and not with an impact driven event, such as that caused by the Deep Impact experiment.

  20. Human brain activity patterns beyond the isoelectric line of extreme deep coma.

    Science.gov (United States)

    Kroeger, Daniel; Florea, Bogdan; Amzica, Florin

    2013-01-01

    The electroencephalogram (EEG) reflects brain electrical activity. A flat (isoelectric) EEG, which is usually recorded during very deep coma, is considered to be a turning point between a living brain and a deceased brain. Therefore the isoelectric EEG constitutes, together with evidence of irreversible structural brain damage, one of the criteria for the assessment of brain death. In this study we use EEG recordings for humans on the one hand, and on the other hand double simultaneous intracellular recordings in the cortex and hippocampus, combined with EEG, in cats. They serve to demonstrate that a novel brain phenomenon is observable in both humans and animals during coma that is deeper than the one reflected by the isoelectric EEG, and that this state is characterized by brain activity generated within the hippocampal formation. This new state was induced either by medication applied to postanoxic coma (in human) or by application of high doses of anesthesia (isoflurane in animals) leading to an EEG activity of quasi-rhythmic sharp waves which henceforth we propose to call ν-complexes (Nu-complexes). Using simultaneous intracellular recordings in vivo in the cortex and hippocampus (especially in the CA3 region) we demonstrate that ν-complexes arise in the hippocampus and are subsequently transmitted to the cortex. The genesis of a hippocampal ν-complex depends upon another hippocampal activity, known as ripple activity, which is not overtly detectable at the cortical level. Based on our observations, we propose a scenario of how self-oscillations in hippocampal neurons can lead to a whole brain phenomenon during coma.

  1. The Radio Luminosity Function and Galaxy Evolution in the Coma Cluster

    Science.gov (United States)

    Miller, Neal A.; Hornschemeier, Ann E.; Mabasher, Bahram; Brudgesm Terrry J.; Hudson, Michael J.; Marzke, Ronald O.; Smith, Russell J.

    2008-01-01

    We investigate the radio luminosity function and radio source population for two fields within the Coma cluster of galaxies, with the fields centered on the cluster core and southwest infall region and each covering about half a square degree. Using VLA data with a typical rms sensitivity of 28 (mu)Jy per 4.4" beam, we identify 249 radio sources with optical counterparts brighter than r = 22 (equivalent to M(sub r) = -13 for cluster member galaxies). Comprehensive optical spectroscopy identifies 38 of these as members of the Coma cluster, evenly split between sources powered by an active nucleus and sources powered by active star formation. The radio-detected star-forming galaxies are restricted to radio luminosities between about 10(exp 21) and 10(exp 22) W/Hz, an interesting result given that star formation dominates field radio luminosity functions below about 10(exp 23) W/Hz. The majority of the radio-detected star-forming galaxies have characteristics of starbursts, including high specific star formation rates and optical spectra with strong emission lines. In conjunction with prior studies on post-starburst galaxies within the Coma cluster, this is consistent with a picture in which late-type galaxies entering Coma undergo a starburst prior to a rapid cessation of star formation. Optically bright elliptical galaxies (Mr less than or equals -20.5) make the largest contribution to the radio luminosity function at both the high (> approx. 3x10(exp 22) W/Hz) and low (< approx. 10(exp 21) W/Hz) ends. Through a stacking analysis of these optically-bright ellipticals we find that they continue to harbor radio sources down to luminosities as faint as 3x10(exp 19) W/Hz. However, contrary to published results for the Virgo cluster we find no evidence for the existence of a population of optically faint (M(sub r) approx. equals -14) dwarf ellipticals hosting strong radio AGN.

  2. A NuSTAR observation of the center of the coma cluster

    DEFF Research Database (Denmark)

    Gastaldello, Fabio; Wik, Daniel R.; Molendi, S.

    2015-01-01

    We present the results of a 55 ks NuSTAR observation of the core of the Coma Cluster. The global spectrum can be explained by thermal gas emission, with a conservative 90% upper limit to non-thermal inverse Compton (IC) emission of 5.1 × 10-12 erg cm-2 s-1 in a 12' × 12' field of view. The bright...

  3. Human brain activity patterns beyond the isoelectric line of extreme deep coma.

    Directory of Open Access Journals (Sweden)

    Daniel Kroeger

    Full Text Available The electroencephalogram (EEG reflects brain electrical activity. A flat (isoelectric EEG, which is usually recorded during very deep coma, is considered to be a turning point between a living brain and a deceased brain. Therefore the isoelectric EEG constitutes, together with evidence of irreversible structural brain damage, one of the criteria for the assessment of brain death. In this study we use EEG recordings for humans on the one hand, and on the other hand double simultaneous intracellular recordings in the cortex and hippocampus, combined with EEG, in cats. They serve to demonstrate that a novel brain phenomenon is observable in both humans and animals during coma that is deeper than the one reflected by the isoelectric EEG, and that this state is characterized by brain activity generated within the hippocampal formation. This new state was induced either by medication applied to postanoxic coma (in human or by application of high doses of anesthesia (isoflurane in animals leading to an EEG activity of quasi-rhythmic sharp waves which henceforth we propose to call ν-complexes (Nu-complexes. Using simultaneous intracellular recordings in vivo in the cortex and hippocampus (especially in the CA3 region we demonstrate that ν-complexes arise in the hippocampus and are subsequently transmitted to the cortex. The genesis of a hippocampal ν-complex depends upon another hippocampal activity, known as ripple activity, which is not overtly detectable at the cortical level. Based on our observations, we propose a scenario of how self-oscillations in hippocampal neurons can lead to a whole brain phenomenon during coma.

  4. The clinic discuss of prognosis and treatment or brainstem infarction combined coma

    Institute of Scientific and Technical Information of China (English)

    Niu Junying; Wanglei; YinShimin; Zheng Yishan; Shijie Qu; Zhanfen

    2000-01-01

    Objective Discuss the relationship between the position, bound of brainstem infarction and .consciousness clog,determinan the prognosis and curative effect. Background and Methods Total brainstem infarction 14 patients,9 male and 5 female,43 to 80 years old.all patients had been checked by CT or MRI,brainstem foliun scanning 6 cases,checked by MRI 8 canes micbrain infarction 2 cases,pon infarction 5 cases,medulla infasction 7 cases the midbrain infarction were rise rapid,inmediately coma,the mydrasis in defect side,opposite body mucsle tension heighten.then both lower limbs straight,both pathology sign masculine.the two cases are all alive .tocked-in syndrom has appeared in 1 case of pon infarction ,and died of combined illness 1 year later. 1 case defect affect centrum of breath and hearlbeat, coma,breath rhythm malajustment,breath stop.threr were no consciousness clog in the other 3 cases ,vertigo,force head position to trouble side, nystagmus, trouble side face hypalgesia,and all cureed .2 cases of medulla infarction appeared quactriplegia ,swallow hardness,anarthriad and so on, 5 others were hemi Watlenberg syndrom,all wcre cured. Results and Discussion coma or no in brainstem infaciton was related with position.it is reparted that midbrain infarction coma was 7.6 persent of brainstem infarction. consciousness clog is distinctness which defect position in midbrain lateral-back, pon ventro defect, not involved ARAS ,lwas locked-in synxdom. brainstem infarction combined combined with freedom breath clog,in medulla was 16.1percent,midorain was 1 1.6 percent, pons ws 83.96 percent the prognosis was.all right in lightly brainsterm infarction, lf involved in both medulla, ventro pon,the prognosis was bad, and lose quadriplegia. CT brainstern foliun scanning would enhanced scanning lay, and helpful for chech up the pathological chanoes of brainstem.

  5. Coma in fatal adult human malaria is not caused by cerebral oedema

    Directory of Open Access Journals (Sweden)

    Pongponratn Emsri

    2011-09-01

    Full Text Available Abstract Background The role of brain oedema in the pathophysiology of cerebral malaria is controversial. Coma associated with severe Plasmodium falciparum malaria is multifactorial, but associated with histological evidence of parasitized erythrocyte sequestration and resultant microvascular congestion in cerebral vessels. To determine whether these changes cause breakdown of the blood-brain barrier and resultant perivascular or parenchymal cerebral oedema, histology, immunohistochemistry and image analysis were used to define the prevalence of histological patterns of oedema and the expression of specific molecular pathways involved in water balance in the brain in adults with fatal falciparum malaria. Methods The brains of 20 adult Vietnamese patients who died of severe malaria were examined for evidence of disrupted vascular integrity. Immunohistochemistry and image analysis was performed on brainstem sections for activation of the vascular endothelial growth factor (VEGF receptor 2 and expression of the aquaporin 4 (AQP4 water channel protein. Fibrinogen immunostaining was assessed as evidence of blood-brain barrier leakage and perivascular oedema formation. Correlations were performed with clinical, biochemical and neuropathological parameters of severe malaria infection. Results The presence of oedema, plasma protein leakage and evidence of VEGF signalling were heterogeneous in fatal falciparum malaria and did not correlate with pre-mortem coma. Differences in vascular integrity were observed between brain regions with the greatest prevalence of disruption in the brainstem, compared to the cortex or midbrain. There was a statistically non-significant trend towards higher AQP4 staining in the brainstem of cases that presented with coma (P = .02. Conclusions Histological evidence of cerebral oedema or immunohistochemical evidence of localised loss of vascular integrity did not correlate with the occurrence of pre-mortem coma in adults with

  6. Selections from 2015: Discovery of Diffuse Galaxies in the Coma Cluster

    Science.gov (United States)

    Kohler, Susanna

    2015-12-01

    Editors Note:In these last two weeks of 2015, well be looking at a few selections from among the most-downloaded paperspublished in AAS journals this year. The usual posting schedule will resume after the AAS winter meeting.Forty-Seven Milky Way-Sized, Extremely Diffuse Galaxies in the Coma ClusterPublished January 2015Main takeaway:Using the Dragonfly Telephoto Array, a team led by Pieter van Dokkum (Yale University) discovered 47 ultra-diffuse galaxies in the Coma galaxy cluster. These galaxies are very large, with half-light (effective) radii of 1.54.6 kpc, similar to that of the Milky Ways disk. But their stellar masses are a factor of 1000 lower than the Milky Ways, and theyre accordingly much dimmer.Plot of the effective radius versus the central surface brightness for the ultra-diffuse Coma cluster galaxies (red markers). These galaxies are similar in size to the Milky Ways disk (blue), but significantly dimmer. [Van Dokkum et al. 2015]Why its interesting:These galaxies make up an odd population. Why are their stellar masses so low? The authors posit that these objects may be failed galaxies that lost their gas after having formed their first generation of stars. Adding to the intrigue, the authors find that in order for these galaxies to hold themselves together at their current distance from the cluster core, they must have a whopping dark-matter fraction of 98%.About the discovery:These ultra-diffuse galaxies were actually discovered entirely by accident. Van Dokkum and collaborators observed the Coma cluster in a project to measure properties of the intra-cluster light and look for streams and tidal features. Surprisingly, their images revealed these faint, uncataloged galaxies.CitationPieter G. van Dokkum et al 2015 ApJ 798 L45. doi:10.1088/2041-8205/798/2/L45

  7. CU Comae a new field double-mode RR Lyrae, the most metal poor discovered to date

    CERN Document Server

    Clementini, G; Fabrizio, L D; Bragaglia, A; Merighi, R; Tosi, M P; Carretta, E; Gratton, R G; Ivans, I I; Kinard, A; Marconi, M; Smith, H A; Wilhelm, R; Woodruff, T; Sneden, C

    2000-01-01

    We report the discovery of a new double-mode RR Lyrae variable (RRd) in the field of our Galaxy: CU Comae. CU Comae is the sixth such RRd identified to date and is the most metal-poor RRd ever detected. Based on BVI CCD photometry spanning eleven years of observations, we find that CU Comae has periods P0=0.5441641 +/-0.0000049d and P1=0.4057605 +/-0.0000018d. The amplitude of the primary (first-overtone) period of CU Comae is about twice the amplitude of the secondary (fundamental) period. The combination of the fundamental period of pulsation P0 and the period ratio of P1/P0=0.7457 places the variable on the metal-poor side of the Petersen diagram, in the region occupied by M68 and M15 RRd's. A mass of 0.83 solar masses is estimated for CU Comae using an updated theoretical calibration of the Petersen diagram. High resolution spectroscopy (R=30,000) covering the full pulsation cycle of CU Comae was obtained with the 2.7 m telescope of the Mc Donald Observatory, and has been used to build up the radial veloc...

  8. The interaction between the solar wind and the heterogeneous neutral gas coma of comet 67P/Churyumov-Gerasimenko

    Science.gov (United States)

    Rubin, Martin; Toth, Gabor; Tenishev, Valeriy; Fougere, Nicolas; Huang, Zhenguang

    2016-07-01

    Comets are surrounded by an extended gas and dust coma. Neutral particles are continuously ionized by solar irradiation and then picked-up by the solar wind. This leads to a complex interaction between the neutral gas coma and the solar wind, which changes over the course of the comet's orbit around the Sun. The European Space Agency's Rosetta spacecraft has been in orbit around comet 67P/Churyumov-Gerasimenko since August 2014. Rosetta carries several instruments to investigate the comet's nucleus and surrounding neutral gas coma and plasma. Part of the payload is the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) that consists of two mass spectrometers and a pressure sensor. ROSINA was designed to measure the neutral gas abundance and composition and low energy ions in the coma in situ. ROSINA observations have shown that the coma is very heterogeneous both in total density and composition of the neutral gas. This heterogeneity is driven in large part by the complex shape of the nucleus and the varying illumination conditions associated with the comet's rotation. In this presentation we will show the time-dependent distribution of the major volatiles around the comet constrained by ROSINA observations. Furthermore we will investigate the impact of the highly non-symmetric neutral gas coma on the interaction of the solar wind with the comet.

  9. Catalog of Ultra-diffuse Galaxies in the Coma Clusters from Subaru Imaging Data

    Science.gov (United States)

    Yagi, Masafumi; Koda, Jin; Komiyama, Yutaka; Yamanoi, Hitomo

    2016-07-01

    We present a catalog of ultra-diffuse galaxies (UDGs) in the Coma cluster. UDGs are a subset of low surface brightness (SB) galaxies with very large effective radii defined by van Dokkum et al. We surveyed the Subaru data archive for deep Suprime-Cam/Subaru R-band images, and used data covering the 1.°7 × 2.°7 region of the Coma cluster. The data are ˜1 magnitude deeper than the data of van Dokkum et al (2015a) in limiting SB. This paper explains the details of our sample selection procedure. This UDG catalog includes positions, magnitudes, effective radii, mean and central SBs, and colors (when available). Comparisons with previous galaxy catalogs in the literature are performed, and we show that the current catalog is the largest for UDGs. We also discuss that most of the UDGs are members of the Coma cluster, and the major axis of the UDGs tends to align toward the cluster center (radial alignment). Based on data collected at Subaru Telescope, which is operated by the National Astronomical Observatory of Japan.

  10. The quenching and survival of ultra-diffuse galaxies in the Coma cluster

    CERN Document Server

    Yozin, C

    2015-01-01

    We conduct the first self-consistent numerical simulations of a recently discovered population of 47 large, faint (ultra-diffuse) galaxies, speculated to lie in the Coma cluster. With structural properties consistent with very large low surface brightness systems (i.e. $\\mu$(g,0)$<24$ mag arcsec$^{\\rm -2}$, r$_{\\rm eff}$ comparable to the Galaxy), the red colour ($\\langle$g-r$\\rangle$$\\sim$0.8) and assumed low metallicity of these objects compels us to consider a scenario in which these are underdeveloped galaxies whose early ($z$$\\simeq$2) accretion to an overdense environment quenched further growth. Our simulations demonstrate the efficacy of this scenario, with respect to available observational constraints, using progenitor galaxy models derived from scaling relations, and idealised tidal/hydrodynamical models of the Coma cluster. The apparent ubiquity of these objects in Coma implies they constitute an important galaxy population, we accordingly discuss their properties with respect to a $\\Lambda$CDM...

  11. Dark and visible matter distribution in Coma cluster: theory vs observations

    CERN Document Server

    Brilenkov, Ruslan; Zhuk, Alexander

    2015-01-01

    We investigate dark and visible matter distribution in the Coma cluster in the case of the Navarro-Frenk-White (NFW) profile. A toy model where all galaxies in the cluster are concentrated inside a sphere of an effective radius $R_{eff}$ is considered. It enables to obtain the mean velocity dispersion as a function of $R_{eff}$. We show that, within the observation accuracy of the NFW parameters, the calculated value of $R_{eff}$ can be rather close to the observable cutoff of the galaxy distribution . Moreover, the comparison of our toy model with the observable data and simulations leads to the following preferable NFW parameters for the Coma cluster: $R_{200} \\approx 1.77\\,h^{-1} \\, \\mathrm{Mpc} = 2.61\\, \\mathrm{Mpc}$, $c=3\\div 4$ and $M_{200}= 1.29 h^{-1}\\times10^{15}M_{\\odot}$. In the Coma cluster the most of galaxies are concentrated inside a sphere of the effective radius $R_{eff}\\sim 3.7$ Mpc and the line-of-sight velocity dispersion is $1004\\, \\mathrm{km}\\, \\mathrm{s}^{-1}$.

  12. The globular cluster systems of 54 Coma ultra-diffuse galaxies: statistical constraints from HST data

    CERN Document Server

    Amorisco, N C; White, S D M

    2016-01-01

    We use data from the HST Coma Cluster Treasury program to assess the richness of the Globular Cluster Systems (GCSs) of 54 Coma ultra-diffuse galaxies (UDGs), and hence to constrain the virial masses of their haloes. For 18 of these the half-light radius exceeds 1.5 kpc. We use a maximum-likelihood method to take account of the high contamination levels. UDG GCSs are poor: for 14 of the largest 18, $N_{GC}<29$ with 90% confidence, $N_{GC}\\leq46$ for the remaining 4. From a stacked analysis of the 18 largest UDGs we estimate $\\langle N_{GC}\\rangle=4.9^{+4.3}_{-3.3}$ (median, 10 and 90% quantiles); the corresponding number for the complementary 36 systems is $\\langle N_{GC}\\rangle=0.8^{+0.9}_{-0.6}$. These results strongly suggest that most Coma UDGs have low-mass haloes. Their GCSs do not display significantly larger richnesses than nearby dwarf galaxies of similar stellar mass.

  13. Fast and Slow Rotators in the Densest Environments: a SWIFT IFS study of the Coma Cluster

    CERN Document Server

    Houghton, R C W; D'Eugenio, F; Scott, N; Thatte, N; Clarke, F; Tecza, M; Salter, G S; Fogarty, L M R; Goodsall, T

    2013-01-01

    We present integral-field spectroscopy of 27 galaxies in the Coma cluster observed with the Oxford SWIFT spectrograph, exploring the kinematic morphology-density relationship in a cluster environment richer and denser than any in the ATLAS3D survey. Our new data enables comparison of the kinematic morphology relation in three very different clusters (Virgo, Coma and Abell 1689) as well as to the field/group environment. The Coma sample was selected to match the parent luminosity and ellipticity distributions of the early-type population within a radius 15' (0.43 Mpc) of the cluster centre, and is limited to r' = 16 mag (equivalent to M_K = -21.5 mag), sampling one third of that population. From analysis of the lambda-ellipticity diagram, we find 15+-6% of early-type galaxies are slow rotators; this is identical to the fraction found in the field and the average fraction in the Virgo cluster, based on the ATLAS3D data. It is also identical to the average fraction found recently in Abell 1689 by D'Eugenio et al...

  14. Near-death experiences in non-life-threatening events and coma of different etiologies

    Directory of Open Access Journals (Sweden)

    Vanessa eCharland-Verville

    2014-05-01

    Full Text Available Background: Near death experiences (NDEs are increasingly being reported as a clearly identifiable physiological and psychological reality of clinical significance. However, the definition and causes of the phenomenon as well as the identification of NDE experiencers is still a matter of debate. To date, the most widely used standardized tool to identify and characterize NDEs in research is the Greyson NDE Scale. Using this scale, retrospective and prospective studies have been trying to estimate their incidence in various populations but few studies have tackled to associate the experiences’ intensity and content related to etiology. Methods: This retrospective investigation assessed the most frequently recounted features of self-reported NDEs after a non-life-threatening event (i.e., NDE-like experience or after a pathological coma (i.e., classical NDEs and according to the etiology of the acute brain insult. We also compared our retrospectively acquired data in anoxic coma with historical data from the published literature on prospective post-anoxic studies using the Greyson NDE Scale. Results: From our 190 reports who met the criteria for NDE (i.e., NDE scale total score Conclusions: It appears that real NDEs after coma of different etiologies are similar to NDE-like experiences occurring after non-life threatening events. Subjects reporting NDEs retrospectively tend to have experienced a different content compared to the prospective experiencers

  15. On the nature of faint Low Surface Brightness galaxies in the Coma cluster

    CERN Document Server

    Adami, C; Ulmer, M P; Cuillandre, J C; Durret, F; Mazure, A; Picat, J P; Scheidegger, R

    2008-01-01

    This project is the continuation of our study of faint Low Surface Brightness Galaxies (fLSBs) in one of the densest nearby galaxy regions known, the Coma cluster. Our goal is to improve our understanding of the nature of these objects by comparing the broad band spectral energy distribution with population synthesis models. The data were obtained with the MEGACAM and CFH12K cameras at the CFHT. We used the resulting photometry in 5 broad band filters (u*, B, V, R, and I), that included new u*-band data, to fit spectral models. With these spectral fits we inferred a cluster membership criterium, as well as the ages, dust extinctions, and photometric types of these fLSBs. We show that about half of the Coma cluster fLSBs have a spectral energy distribution well represented in our template library while the other half present a flux deficit at ultraviolet wavelengths. Among the well represented, ~80% are probably part of the Coma cluster based on their spectral energy distribution. They are relatively young (yo...

  16. [Euthanasia of patients in coma vigil. Results on German medical staff attitudes].

    Science.gov (United States)

    Böttger-Kessler, G; Beine, K H

    2007-07-01

    An examination was made concerning doctors' and nursing staff's attitudes towards active euthanasia of patients suffering from coma vigil (2652 doctors and 5785 nursing staff were interviewed). This investigation made clear that most of the persons asked about this group of patients voted for a change in German laws following the Dutch example. There were noticeable differences observed between the professional groups. A majority (64.79%) were convinced that under certain circumstances it is justified to end intentionally the life of persons in a coma vigil. Of the nursing staff, 70.38% were in favour of this attitude, and 51.53% of the doctors share this opinion. Certain groups supported the question of active euthanasia more clearly than others. These were young participants in the investigation, first-time employees, nondenominational interviewees, those who are dissatisfied with their job situation, who are from the newly-formed German states, and who are divorced. The attitudes expressed by all these people originate in many different motives: thoughts about the patients, aspects concerning jobs, and personal aspects had an influence on results of the investigation. This single investigation which was restricted to patients suffering from coma vigil and to employees of the public health service, does not prove that the total population has generally changed its attitude toward active euthanasia. It is impossible to justify the necessity of new laws about euthanasia based on the above results.

  17. Negative Ion Chemistry in the Coma of Comet 1P/Halley

    Science.gov (United States)

    Cordiner, M. A.; Charnley, S. B.

    2012-01-01

    Negative ions (anions) were identified in the coma of comet 1P/Halley from in-situ measurements performed by the Giotto spacecraft in 1986. These anions were detected with masses in the range 7-110 amu, but with insufficient mass resolution to permit unambiguous identification. We present details of a new chemical-hydrodynamic model for the coma of comet Halley that includes - for the first time - atomic and molecular anions, in addition to a comprehensive hydrocarbon chemistry. Anion number densities arc calculated as a function of radius in the coma, and compared with the Giotto results. Important anion production mechanisms arc found to include radiative electron attachment, polar photodissociation, dissociative electron attachment, and proton transfer. The polyyne anions C4H(-) and C6H(-) arc found to be likely candidates to explain the Giotto anion mass spectrum in the range 49-73 amu. Thc CN(-) anion probably makes a significant contribution to the mass spectrum at 26 amu. Larger carbon-chain anions such as C8H(1) can explain the peak near 100 amu provided there is a source of large carbon-chain-bearing molecules from the cometary nucleus.

  18. End-of-life and brain death in acute coma and disorders of consciousness.

    Science.gov (United States)

    Greer, David M; Curiale, Gioacchino G

    2013-04-01

    Consulting neurologists are often asked to evaluate patients in acute nontraumatic coma. The authors review prognostication of functional outcomes, determining brain death, and managing end-of-life care. Prognostication of outcome after cardiac arrest in comatose patients is a frequently encountered scenario with high-stakes implications. However, current guidelines are limited by a failure to address the use of therapeutic hypothermia and thus may lead to overly pessimistic outcome prediction. Pupillary light responses and corneal reflexes remain highly predictive clinical signs of a poor prognosis. Motor responses have a high false-positive rate for predicting a poor outcome, especially in patients treated with therapeutic hypothermia. Ancillary testing with electroencephalography, somatosensory evoked potentials, serum neuron-specific enolase, and neuroimaging is often useful in predicting outcomes. Brain death is a clinical condition of irreversible coma of known cause with absent brainstem reflexes and apnea. An understanding of the value of confirmatory testing and the potential for confounding factors is essential in making a correct diagnosis. As coma carries a high mortality rate, neurologists must be capable of guiding goals of care, discussing end-of-life issues, and understanding organ-procurement procedures.

  19. Significance of ambulatory EEG on prognosis evaluation of patients with coma

    Directory of Open Access Journals (Sweden)

    Jun-su YANG

    2016-10-01

    Full Text Available The result of ambulatory EEG (AEEG examination on 168 comatose patients showed that AEEG grading was negatively correlated with Glasgow Coma Scale (GCS score (r = - 0.995, P = 0.005. More serious the patients' condition was and the deeper coma they were in, the lower GCS score and the higher EEG grade they would got. Among all patients, there were 84 cases with AEEG grade Ⅱ, in whom 74 cases (88.10% had favorable prognosis; 26 cases (49.06% of 53 cases with grade Ⅲ and 4 cases (12.90% of 31 cases with grade Ⅳ - Ⅴ had favorable prognosis. The differences between groups had statistical significance (χ2 = 60.565, P = 0.042. AEEG is non-invasive, repeatable and easy to operate, which is in favor of the neurological evaluation and prognosis of patients with coma. DOI: 10.3969/j.issn.1672-6731.2016.10.013

  20. The HST/ACS Coma Cluster Survey. II. Data Description and Source Catalogs

    Science.gov (United States)

    Hammer, Derek; Kleijn, Gijs Verdoes; Hoyos, Carlos; Den Brok, Mark; Balcells, Marc; Ferguson, Henry C.; Goudfrooij, Paul; Carter, David; Guzman, Rafael; Peletier, Reynier F.; Smith, Russell J.; Graham, Alister W.; Trentham, Neil; Peng, Eric; Puzia, Thomas H.; Lucey, John R.; Jogee, Shardha; Aguerri, Alfonso L.; Batcheldor, Dan; Bridges, Terry J.; Davies, Jonathan I.; Del Burgo, Carlos; Erwin, Peter; Hornschemeier, Ann; Hudson, Michael J.

    2010-01-01

    The Coma cluster, Abell 1656, was the target of a HST-ACS Treasury program designed for deep imaging in the F475W and F814W passbands. Although our survey was interrupted by the ACS instrument failure in early 2007, the partially-completed survey still covers approximately 50% of the core high density region in Coma. Observations were performed for twenty-five fields with a total coverage area of 274 aremin(sup 2), and extend over a wide range of cluster-centric radii (approximately 1.75 Mpe or 1 deg). The majority of the fields are located near the core region of Coma (19/25 pointings) with six additional fields in the south-west region of the cluster. In this paper we present SEXTRACTOR source catalogs generated from the processed images, including a detailed description of the methodology used for object detection and photometry, the subtraction of bright galaxies to measure faint underlying objects, and the use of simulations to assess the photometric accuracy and completeness of our catalogs. We also use simulations to perform aperture corrections for the SEXTRACTOR Kron magnitudes based only on the measured source flux and its half-light radius. We have performed photometry for 76,000 objects that consist of roughly equal numbers of extended galaxies and unresolved objects. Approximately two-thirds of all detections are brighter than F814W=26.5 mag (AB), which corresponds to the 10sigma, point-source detection limit. We estimate that Coma members are 5-10% of the source detections, including a large population of compact objects (primarily GCs, but also cEs and UCDs), and a wide variety of extended galaxies from cD galaxies to dwarf low surface brightness galaxies. The initial data release for the HST-ACS Coma Treasury program was made available to the public in August 2008. The images and catalogs described in this study relate to our second data release.

  1. A brain-machine interface for control of medically-induced coma.

    Science.gov (United States)

    Shanechi, Maryam M; Chemali, Jessica J; Liberman, Max; Solt, Ken; Brown, Emery N

    2013-10-01

    Medically-induced coma is a drug-induced state of profound brain inactivation and unconsciousness used to treat refractory intracranial hypertension and to manage treatment-resistant epilepsy. The state of coma is achieved by continually monitoring the patient's brain activity with an electroencephalogram (EEG) and manually titrating the anesthetic infusion rate to maintain a specified level of burst suppression, an EEG marker of profound brain inactivation in which bursts of electrical activity alternate with periods of quiescence or suppression. The medical coma is often required for several days. A more rational approach would be to implement a brain-machine interface (BMI) that monitors the EEG and adjusts the anesthetic infusion rate in real time to maintain the specified target level of burst suppression. We used a stochastic control framework to develop a BMI to control medically-induced coma in a rodent model. The BMI controlled an EEG-guided closed-loop infusion of the anesthetic propofol to maintain precisely specified dynamic target levels of burst suppression. We used as the control signal the burst suppression probability (BSP), the brain's instantaneous probability of being in the suppressed state. We characterized the EEG response to propofol using a two-dimensional linear compartment model and estimated the model parameters specific to each animal prior to initiating control. We derived a recursive Bayesian binary filter algorithm to compute the BSP from the EEG and controllers using a linear-quadratic-regulator and a model-predictive control strategy. Both controllers used the estimated BSP as feedback. The BMI accurately controlled burst suppression in individual rodents across dynamic target trajectories, and enabled prompt transitions between target levels while avoiding both undershoot and overshoot. The median performance error for the BMI was 3.6%, the median bias was -1.4% and the overall posterior probability of reliable control was 1 (95

  2. Recorrência da Crise Convulsiva após Terapia Anticonvulsivante com Sulfato de Magnésio em Pacientes com Eclâmpsia Recurrence of Seizures after Anticonvulsant Therapy with Magnesium Sulfate in Patients with Eclampsia

    Directory of Open Access Journals (Sweden)

    Melania Maria Ramos de Amorim

    2000-04-01

    . Patients and Methods: a prospective cohort study was conducted, enrolling all cases of eclampsia managed at IMIP between January/1995 and June/1998. Magnesium sulfate and oxygen therapy were administered routinely and interruption of pregnancy was performed after maternal stabilization. The frequency of recurrence of seizures and its association with maternal complications were determined. chi² test for association was used at a 5% level of significance. Results: twelve cases presented recurrence of convulsions after magnesium sulfate (10% and all received a repeated dose. In four of them convulsions persisted and they received intravenous diazepam. After diazepam, one patient still had seizures, with unsuccessful administration of phenytoin and therefore barbituric coma was induced (thionembutal. This patient had a CT-scan with evidence of intracerebral hemorrhage. Maternal complications were significantly more frequent in the group with recurrence: coma (16.7% versus 0.95, acidosis (50% versus 2.9%, pulmonary edema (16.7% versus 2.9%, cerebral hemorrhage (16.7% versus 0% and acute renal failure (16.7% versus 1.9%. Three cases of maternal death occurred in patients with recurrence (25% versus 2 cases in patients without recurrence (1.9%. Conclusions: rate of recurrence after anticonvulsant therapy with magnesium sulfate is low (10% but it is associated with increased maternal morbidity and mortality. These cases must be managed in an intensive care unit and submitted to routine CT-scan because cerebral hemorrhage can be the cause of recurrence.

  3. Comet 67P Nucleus Water Ice Distribution and Evolution Inferred from Inner Coma Structure Seen by Rosetta/MIRO

    Science.gov (United States)

    Lee, Seungwon; von Allmen, Paul; MIRO Team

    2016-10-01

    The spatial structure and temporal evolution of the inner coma of Comet 67P have been observed by Microwave Instrument on Rosetta Orbiter (MIRO) since the Rosetta Orbiter has rendezvoused with Comet 67P in August 2014. Among the several cometary gas emission lines that the MIRO spectrometer is tuned to, the water isotopologue H218O line is optically thin and is used to probe the inner coma structure as the MIRO beam scans the space near the comet nucleus. The water line area/strength shows clearly that the day side of coma has a lot more gas than the night side of coma and the summer hemisphere side of coma has a lot more gas than the winter hemisphere side of coma. These diurnal and seasonal dependencies strongly suggest that the water gas in the coma is from the sublimation of ice in the nucleus, where its rate greatly depends on the thermal condition of surface and near-surface governed by the sun illumination condition. In addition to the sun illumination condition, the water ice distribution on 67P nucleus affects the inner coma structure. We model the inner coma structures with various ice distributions and compare them with the observation. The comparison undoubtedly shows that the ice is not uniformly distributed on 67P nucleus. The observation favors the model with the ice distributed only in polar caps in both poles. The observation also shows the evidence of temporal evolution of the ice distribution. The southern polar ice cap was less active a few months before the perihelion (August 2015), became more active near the perihelion, and became less active a few months after the perihelion. Note that the ice cap activity change due to the temperature-dependent sublimation rate change is already taken into account, and does not explain the temporal variation of the inner coma structure. This result indicates that there was a change of ice distribution (polar cap size) or ice location near the surface (how deep the dust layer covers the ice).

  4. Why do insects enter and recover from chill coma? Low temperature and high extracellular potassium compromises muscle function in Locusta migratoria

    DEFF Research Database (Denmark)

    Findsen, Anders; Pedersen, Thomas Holm; Petersen, Asbjørn G

    2014-01-01

    When exposed to low temperatures, many insect species enter a reversible comatose state (chill coma), which is driven by a failure of neuromuscular function. Chill coma and chill coma recovery have been associated with a loss and recovery of ion-homeostasis (particularly extracellular [K...... of chill coma in locusts exposed to cold at varying rates of cooling. Chill coma onset temperature changed maximally 1°C under different cooling rates and marked disturbances of ion homeostasis were not observed at any of the cooling rates. In a second set of experiments we used isolated tibial muscle...... these two stressors almost abolished force production. Thus, low temperature alone may be responsible for chill coma entry, rather than a disruption of extracellular K+ homeostasis. Since [K+] also has a large effect on tetanic force production, it is hypothesized that recovery of extracellular [K...

  5. Responsiveness of a patient in a persistent vegetative state after a coma to weekly injections of autologous activated immune cells: a case report

    Directory of Open Access Journals (Sweden)

    Fellerhoff Barbara

    2012-01-01

    Full Text Available Abstract Introduction An 82-year-old Caucasian woman had remained in a persistent vegetative state after a coma of seven months duration, which occurred after a stroke with hemiplegia, nine years previously. The persistent vegetative state could be reversed in part by weekly injections with activated immune cells. After therapy, our patient responded to commands in addition to regaining spontaneous movements of both arms and the ability to swallow. This is the first report on the treatment with activated immune cells of a patient in a persistent vegetative state after a coma. Case presentation An 82-year-old Caucasian woman presented with a persistent vegetative state subsequent to a coma. She retained respiratory and autonomic functions. As contact was not possible, physiotherapy was passive. Her skin was yellowish, and our patient did not move by herself. Vomiting repeatedly resulted from tube feeding. After a once-weekly treatment with activated immune cells sampled from our patient's blood and activated in vitro, several of her functions gradually returned. Our patient opened her eyes in the requested direction and turned her head toward people entering the room. She 'supported' nursing efforts, as the nurse noted a loss of spastic motions. The strength in both her arms returned, and she spontaneously moved her arm on the side experiencing hemiplegia. After three months, our patient could stick out her tongue upon demand. Finally, the swallow reflexes of our patient started to return. However, tube feeding was continued, and our patient died after aspiration of vomit following a feeding. Conclusion The success of treatment with autologous activated immune cells in this patient may have resulted from the production of neuroactive substances, such as neurotrophin-3 and brain-derived neurotrophic factor, by activated immune cells. The deterioration of our patient could be reversed, as demonstrated by the restoration of motor strength in her

  6. Escala de coma de Glasgow pediátrica modificada para cães Pediatric Glasgow coma scale modified for dogs

    Directory of Open Access Journals (Sweden)

    M.B. Andrade

    2010-02-01

    Full Text Available Com o objetivo de modificar a escala de coma de Glasgow pediátrica para utilização na medicina veterinária, foram utilizados 30 cães adultos com alterações neurológicas passíveis de avaliação da consciência. A escala modificada para cães foi aplicada em três momentos com intervalos de 48 horas entre eles, resultando em 90 eventos diversos. A escala foi aplicada para avaliação da abertura ocular (AO, da melhor resposta associada à vocalização (MRV e da melhor resposta motora (MRM. Com a análise fatorial para os indicadores AO, MRV e MRM, obtiveram-se valores iniciais de 2,482, 0,302 e 0,215, respectivamente. A variância foi de 82,7%, 10,1% e 7,2%, respectivamente, e cumulativa de 82,7%, 92,8% e 100%, respectivamente. A extração esperada do principal fator, AO, foi de 2,482 com variância de 82,7% e cumulativa de 82,7%. O resultado da avaliação da consciência dos cães foi normal em 10% dos animais, alteração leve em 20%, moderada em 45% e grave em 25%, com escores de Glasgow iguais a 15, entre 13 e 14, entre 9 e 12 e entre 8 e 3, respectivamente. A escala de coma de Glasgow pediátrica modificada para cães é ferramenta segura para avaliação da consciência de cães adultos.The pediatric Glasgow coma scale was modified for use in veterinary medicine. Thirty adult dogs with neurological alterations susceptible to evaluation of the conscience were studied. The modified scale for dogs was applied at three moments with intervals of 48 hours, resulting in 90 events. The scale was applied for evaluation of the ocular opening (OO, the best answer associated to vocalization (BAV, and the best motor answer (BMA. With the factorial analysis for the indicators OO, BAV, and BMA the initial values of 2.482, 0.302, and 0.215, respectively, were obtained. The variance was of 82.7%, 10.1%, and 7.2%, respectively, and cumulative of 82.7%, 92.8%, and 100%, respectively. The expected extraction of the main factor, OO, was 2.482 with

  7. Escala de coma de Glasgow pediátrica modificada para cães Pediatric Glasgow coma scale modified for dogs

    OpenAIRE

    M.B. Andrade; E.F. Cole; Evêncio Neto,J.; Silva,A.C.J.; G.A.S. Aleixo; A.L.T. Cunha

    2010-01-01

    Com o objetivo de modificar a escala de coma de Glasgow pediátrica para utilização na medicina veterinária, foram utilizados 30 cães adultos com alterações neurológicas passíveis de avaliação da consciência. A escala modificada para cães foi aplicada em três momentos com intervalos de 48 horas entre eles, resultando em 90 eventos diversos. A escala foi aplicada para avaliação da abertura ocular (AO), da melhor resposta associada à vocalização (MRV) e da melhor resposta motora (MRM). Com a aná...

  8. Hemometabolismo cerebral: variações na fase aguda do coma traumático Cerebral hemometabolism: variability in the acute phase of traumatic coma

    Directory of Open Access Journals (Sweden)

    ANTONIO L. E. FALCÃO

    2000-09-01

    Full Text Available OBJETIVO: avaliar as interrelações entre as alterações hemometabólicas cerebrais e sistêmicas em pacientes com traumatismo craniencefálico (TCE grave submetidos a um protocolo terapêutico padronizado. DESENHO: estudo prospectivo, intervencionista em pacientes com coma traumático. LOCAL: uma UTI geral em hospital universitário. PACIENTES E MÉTODOS: vinte e sete pacientes (21M e 6F, idade 14-58 anos, com TCE grave, com três a oito pontos na escala de coma de Glasgow, foram avaliados prospectivamente segundo um protocolo cumulativo padronizado para tratamento da hipertensão intracraniana aguda, o qual incluía medidas rotineiras da pressão intracraniana (PIC e da extração cerebral de oxigênio (ECO2. Foram analisadas as interrelações hemometabólicas envolvendo: pressão arterial média (PAM, PIC, pressão parcial de gás carbônico arterial (PaCO2, ECO2, pressão de perfusão cerebral (PPC e extração sistêmica de oxigênio (ESO2. INTERVENÇÕES: apenas as padronizadas no protocolo terapêutico. RESULTADOS: não houve correlação entre a ECO2 e a PPC (r = -0,07; p = 0,41. Houve correlação inversa entre a PaCO2 e a ECO2 (r = -0,24; p = 0,005 e direta entre a ESO2 e a ECO2 (r = 0,24; p = 0,01. A mortalidade geral dos pacientes foi de 25,9% (7/27. CONCLUSÃO: 1 a PPC não se correlaciona com a ECO2 em quaisquer níveis de PIC; 2 a ECO2 está estreitamente relacionada aos diferentes níveis de PaCO2 ; e 3 durante a hiperventilação otimizada existe um acoplamento entre a ECO2 e a ESO2.OBJECTIVE: to evaluate the interrelationships between cerebral and systemic hemometabolic alterations in patients with severe traumatic brain injury managed according to a standardized therapeutic protocol. DESIGN: prospective, interventional study in patients with traumatic coma. SETTING: a general Intensive Care Unit in a teaching hospital. PATIENTS AND METHODS: twenty-seven patients (21M e 6F, aging 14--58 years, with severe acute brain trauma

  9. Sinais vitais e expressão facial de pacientes em estado de coma Signos vitales y expresión facial de pacientes en estado de coma Vital signs and facial expression of patients in coma

    Directory of Open Access Journals (Sweden)

    Ana Cláudia Giesbrecht Puggina

    2009-06-01

    Full Text Available O objetivo foi verificar a influência da música e mensagem oral sobre os Sinais Vitais e Expressão Facial dos pacientes em coma fisiológico ou induzido. Realizou-se um Ensaio Clínico Controlado e Randomizado. A amostra consistiu-se de 30 pacientes de Unidade de Terapia Intensiva, que foram divididos em 2 grupos: Grupo Controle (sem estímulos auditivos e Grupo Experimental (com estímulos auditivos. Os pacientes foram submetidos a 3 sessões, em dias consecutivos. Encontraram-se alterações estatisticamente significativas nos sinais vitais (saturação de O2 - sessão 1; saturação de O2 - sessão 3; freqüência respiratória - sessão 3 durante a mensagem e na expressão facial, sessão 1, durante a música e a mensagem. Aparentemente a mensagem foi um estímulo mais forte do que a música em relação à capacidade de produzir respostas fisiológicas sugestivas de audição.El objetivo era verificar la influencia de la música y del mensaje verbal en los Señales Vitales y la Expresión Facial de los pacientes en coma fisiológico o inducido. Un Ensayo Clínico Controlado y Randomizado fue echo. La muestra fue consistida en 30 pacientes de Unidad de terapia Intensiva, que fueran divididos en 2 grupos: Grupo Control (sin estímulos auditivos y Grupo Experimental (con los estímulos auditivos. Los pacientes fueran sometidos a las 3 sesiones, en días consecutivos. Los cambios estadísticamente significativos en las Señales Vitales fueran encuentrados (saturación del oxigeno - sesión 1; saturación del oxigeno - sesión 3; frecuencia respiratoria - sesión 3 durante el mensaje y en la Expresión Facial, sesión 1, durante música y el mensaje. Aparentemente el mensaje era uno estimulo más fuerte de qué la música en lo que refiere a la capacidad de producir respuestas fisiológicas de audición.The objective was to check music and voice message influence on the Vital Signals and Facial Expressions of patients in physiological or

  10. Triage and nursing care of emergency coma patients%急诊昏迷患者分诊与护理

    Institute of Scientific and Technical Information of China (English)

    王学勤; 吕荣菊; 陈霞

    2015-01-01

    Objective:To explore the triage and nursing care of acute coma patients. Methods:The clinical materials of 265 cases with coma in the emergency department of our hospital from January,2013 to June,2014 were analyzed retro-spectively. Results:Among the 142 patients with cerebrovascular diseases,63 cases of severe craniocerebral injury,25 ca-ses of poisoning,15 cases of Hypoglycemic coma,8 cases of diabetic hyperosmolar coma,3 cases of Uremic coma,3 pa-tients with hepatic coma,4 cases of heat stroke coma,2 cases of unidentified cause coma,the triage accuracy was 92%. Conclusion:Solid basic skills,rich medical knowledge and the correct timely identification of emergency triage of coma pa-tients play a decisive role in making clear the causes as soon as possible. Strengthening the accurate and effective emergen-cy treatment and nursing care directly affects the success rate of rescue and rehabilitation of patients.%目的:探讨急诊昏迷患者的分诊与护理。方法选择我院急诊科2013年1月-2014年6月接诊的265例急诊昏迷患者资料进行回顾性分析。结果脑血管病142例,严重颅脑创伤63例,各类中毒25例,低血糖昏迷15例,糖尿病高渗性昏迷8例,尿毒症昏迷3例,肝昏迷3例,中暑昏迷4例,不明原因昏迷2例,分诊正确率92%。结论具备扎实的基本功和丰富的医学知识,正确及时做好对急诊昏迷患者的鉴别分诊,对尽快明确病因起决定作用;及时加强准确有效的急救治疗与护理,直接影响最终的抢救成功率以及患者的康复情况。

  11. S0 galaxies in the Coma cluster: Environmental dependence of the S0 offset from the Tully-Fisher relation

    CERN Document Server

    Rawle, T D; Smith, Russell J; Head, J T C G

    2013-01-01

    We present deep GMOS long-slit spectroscopy of 15 Coma cluster S0 galaxies, and extract kinematic properties along the major axis to several times the disc scale-length. Supplementing our dataset with previously published data, we create a combined sample of 29 Coma S0s, as well as a comparison sample of 38 Coma spirals. Using photometry from SDSS and 2MASS, we construct the Tully-Fisher relation (TFR; luminosity versus maximum rotational velocity) for S0 galaxies. At fixed rotational velocity, the Coma S0 galaxies are on average fainter than Coma spirals by 1.10$\\pm$0.18, 0.86$\\pm$0.19 and 0.83$\\pm$0.19 mag in the g, i and Ks bands respectively. The typical S0 offsets remain unchanged when calculated relative to large field-galaxy spiral samples. The observed offsets are consistent with a simple star formation model in which S0s are identical to spirals until abrupt quenching occurs at some intermediate redshift. The offsets form a continuous distribution tracing the time since the cessation of star formatio...

  12. Mapping of coma anisotropies to plasma structures of weak comets: a 3-D hybrid simulation study

    Directory of Open Access Journals (Sweden)

    N. Gortsas

    2009-04-01

    Full Text Available The effects of coma anisotropies on the plasma environment of comets have been studied by means of a 3-D hybrid model which treats electrons as a massless, charge-neutralizing fluid, whereas ion dynamics are covered by a kinetic approach. From Earth-based observations as well as from in-situ spacecraft measurements the shape of the coma of many comets is ascertained to be anisotropic. However, most plasma simulation studies deploy a spherically symmetric activity pattern. In this paper anisotropy is studied by considering three different coma shape models. The first model is derived from the Haser model and is characterised by spherically symmetry. This reference model is then compared with two different neutral gas shape models: the dayside restricted model with no nightside activity and a cone shaped model with opening angle of π/2. In all models the integrated surface activity is kept constant. The simulations have been done for the Rosetta target comet 67P/Churyumov-Gerasimenko for two heliocentric distances, 1.30 AU and 3.25 AU. It is found that shock formation processes are modified as a result of increasing spatial confinement. Characteristic plasma structures of comets such as the bow shock, magnetic barrier region and the ion composition boundary exhibit a shift towards the sun. In addition, the cone shaped model leads to a strong increase of the mass-loaded region which in turn leads to a smooth deceleration of the solar wind flow and an increasing degree of mixture between the solar wind and cometary ion species. This creates an additional transport channel of the magnetic field from the magnetic barrier region away which in turn leads to a broadening of this region. In addition, it leads to an ion composition boundary which is only gradually developed.

  13. Ultraviolet OH prompt emission in the innermost coma of 103P/Hartley 2

    Science.gov (United States)

    La Forgia, F.; A'Hearn, M.; Lazzarin, M.; Magrin, S.; Bertini, I.; Pajola, M.; Barbieri, C.; Kueppers, M.

    2014-07-01

    The hyperactive Jupiter-family comet 103P/Hartley 2, the target of the EPOXI mission, has been visited on 4 November 2010 at a distance of 694 km, when it was at 1.064 au from the Sun. Spectral observations of the ambient coma show that H_2O is enhanced from the central waist, while CO_2 and icy grains seem to be coming out mainly from the two lobes [1,2]. Visible observations in the OH filter of the MRI camera onboard EPOXI have been used to investigate the distribution of the OH daughter species in the coma. These data reveal an evident radial structure in the very inner coma below 35 km from the nucleus (see Figure), appearing to be coming directly from the nucleus, in the region of the central waist. This is in agreement with the water distribution found by [1]. The OH resonance fluorescence emission band at 308.5 nm, caused by the transition A^2Σ-X^2Π (0,0), has been used indeed for years as a tracer of water parent molecules. Nevertheless, even for the active Sun, the OH fluorescence lifetime is about 10^{5} s, suggesting that it is not expected to be observed so close to the nucleus. OH has been found to cause prompt emission (PE) at both IR and UV wavelengths and has been tentatively detected in a few comets [3-6]. We report theoretical computations showing a strong possibility that the innermost OH structure observed in the MRI images of Hartley 2 could possibly be associated with OH ultraviolet PE.

  14. Radio-Observaciones del OH EN la Coma del Cometa Halley Desde EL Hemisferio Sur

    Science.gov (United States)

    Silva, A. M.; Bajaja, E.; Morras, R.; Cersosimo, J. C.; Martin, M. C.; Arnal, E. M.; Poppel, W. G. L.; Colomb, F. R.; Mazzaro, J.; Olalde, J. C.; Boriakoff, V.; Mirabel, I. F.

    1987-05-01

    Se utilizó una antena de 30 metros del Instituto Argentino de Radioastronomía para observaciones diarias Cf ebrero a abril de 1986) de la transición en 1667 MHz ( λ = 18 cm) del OH en la coma del cometa Halley. De las observaciones realizadas se concluye: 1) El número promedio de moléculas de OH en la coma durante 37 días de observación fue de (8.9±3.5)x1034 moléculas, lo que implica una tasa de producción promedio de OH de 1.8x1029 moléculas seg-1 y consecuentemente una pérdida de masa promedio de 17±6 toneladas seg-1 . Este valor está de acuerdo con las mediciones realizadas por las sondas Vega y Giotto. 2) El monitoreo desde el lAR revela la existencia de variaciones bruscas en los flujos de absorción del OH. Estas variaciones son consistentes con los modelos que representan la producción gaseosa a partir de ejecciones y/o desprendimientos discretos de materia congelada del núcleo. 3) Las variaciones en la densidad de flujo son consistentes con las estimaciones de los tiem- pos de vida medios del H2O y del OH en presencia del campo de radiación solar. 4) Se encuentra una correlación entre la intensidad del flujo absorbido y anisotropías en Ia dinamica de la coma.

  15. Thermal SZ fluctuations in the ICM: probing turbulence and thermodynamics in Coma cluster with Planck

    Science.gov (United States)

    Khatri, Rishi; Gaspari, Massimo

    2016-11-01

    We report the detection of thermal Sunyaev-Zeldovich (SZ) effect fluctuations in the intracluster medium (ICM) of Coma cluster observed with Planck. The SZ data links the maximum observable X-ray scale to the large Mpc scale, extending our knowledge of the power spectrum of ICM fluctuations. Deprojecting the 2D SZ perturbations into 3D pressure fluctuations, we find an amplitude spectrum which peaks at δP/P = 33 ± 12 and 74 ± 19 per cent in the 15 and 40 arcmin radius region, respectively. We perform tests to ensure fluctuations are intrinsic to the cluster and not due to noise contamination. By using high-resolution hydrodynamical models, we improve the ICM turbulence constraints in Coma, finding 3D Mach number Ma3d = 0.8 ± 0.3 (15 arcmin region), increasing to supersonic values at larger radii (40 arcmin) and an injection scale Linj ≈ 500 kpc. Such properties are consistent with driving due to mergers, in particular tied to internal galaxy groups. The large pressure fluctuations show that Coma is in adiabatic mode (mediated by sound waves), rather than isobaric mode (mediated by buoyancy waves). As predicted by turbulence models, the distribution of SZ fluctuations is lognormal with mild non-Gaussianities (heavy tails). The substantial non-thermal pressure support implies hydrostatic mass bias bM = -15 to -45 per cent from the core to the outskirt region, respectively. While total SZ power probes the thermal energy content, the SZ fluctuations constrain the non-thermal deviations important for precision cosmology. The proposed, novel approach can be exploited by multifrequency observations using ground-based interferometers and future space cosmic microwave background missions.

  16. Juan Comas's summary history of the American association of physical anthropologists (1928-1968).

    Science.gov (United States)

    Alfonso, Marta P; Little, Michael A

    2005-01-01

    This translation of Juan Comas's Summary History of the American Association of Physical Anthropologists was originally published in Spanish by the Instituto Nacional de Antropología e Historia, Mexico, in 1969 (Departamento de Investigaciones Antropológicas, Publication 22). Physical anthropologists from North America and members of the American Association of Physical Anthropologists owe Juan Comas a debt of gratitude for having labored to produce this Summary History of the AAPA. There is much useful and interesting material in this document: extensive endnotes that are helpful to the historian of the profession; an appendix of the Journal issues where the proceedings of annual meetings can be found; a detailed listing of contributors of papers to annual meetings from 1930-1968; a warm acknowledgment and history of the contributions of the Wenner-Gren Foundation to biological anthropology; a history of the Yearbook of Physical Anthropology; and comments on the short-lived PA Newsletter. In addition, there are appendices with the founding AAPA Constitution and By-Laws from 1930 and as they existed in 1968. All of this synoptic information saves the reader with interests in the history of the AAPA considerable effort, especially when few university and college libraries have the full (old and new) series of the AJPA on their shelves. We have tried to provide a translation of Comas's history that is faithful to the original Spanish-language publication. In a few cases, we shortened sentences and applied a slightly more modern usage than was popular in the late 1960s.

  17. [Nursing intervention in the case of coma concerning the patient and his family].

    Science.gov (United States)

    Aguarón García, M J; Ricomà Muntané, R; Ferrater Cubells, M; Acebedo Urdiales, S; Rubio Rico, L

    2000-10-01

    This article presents a standardized treatment plan for the first few weeks an adult is in coma, after the acute phase, as a practical guide clarifying the treatment to follow in this process. First, the authors spell out the process to follow. Second, they standardize the characteristics which define persons undergoing these processes. As a fundamental aspect, the authors highlight the importance to work under treatment conditions which the patient and his/her family must confront so as to provide a standard preventive treatment for these problems. Nursing diagnoses are viewed as prevalent. The treatment situations and the diagnoses which enter in this study fall under the V. Henderson model.

  18. Coma in the course of severe poisoning after consumption of red fly agaric (Amanita muscaria).

    Science.gov (United States)

    Mikaszewska-Sokolewicz, Małgorzata A; Pankowska, Sylwestra; Janiak, Marek; Pruszczyk, Piotr; Łazowski, Tomasz; Jankowski, Krzysztof

    2016-01-01

    Red fly agaric poisoning is rare. It can be consumed for suicidal purposes or its psychedelic effect. The paper describes the case of a young men, who fell into a coma after ingestion of the red toadstools. Quick identification of the poison, early use of gastric lavage and symptomatic treatment resulted in regression of symptoms and lead to the patient's discharge from the hospital on the third day after intoxication. Authors discussing the poisonous alkaloids contained in the red toadtools: ibotenic acid, muscimol, muscasone and muscarine and theirs properties, responsible for the symptoms of intoxication.

  19. Coma y acidosis metabólica: Intoxicación por metanol

    OpenAIRE

    2011-01-01

    La intoxicación por metanol es un proceso poco frecuente en la actualidad, a pesar de su uso habitual en la industria, laboratorios y hogar. La vía de intoxicación suele ser la oral y, dada su elevada mortalidad, debe considerarse siempre una intoxicación grave. Se presenta el caso clínico de un paciente joven extranjero sin antecedentes, en coma y con acidosis metabólica grave, que evoluciona a muerte encefálica a pesar de establecer medidas de soporte y tratamiento específico (corrección de...

  20. GLOBULAR CLUSTERS AND SPUR CLUSTERS IN NGC 4921, THE BRIGHTEST SPIRAL GALAXY IN THE COMA CLUSTER

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Myung Gyoon; Jang, In Sung, E-mail: mglee@astro.snu.ac.kr, E-mail: isjang@astro.snu.ac.kr [Astronomy Program, Department of Physics and Astronomy, Seoul National University, Gwanak-gu, Seoul 151-742 (Korea, Republic of)

    2016-03-01

    We resolve a significant fraction of globular clusters (GCs) in NGC 4921, the brightest spiral galaxy in the Coma cluster. We also find a number of extended bright star clusters (star complexes) in the spur region of the arms. The latter are much brighter and bluer than those in the normal star-forming region, being as massive as 3 × 10{sup 5} M{sub ⊙}. The color distribution of the GCs in this galaxy is found to be bimodal. The turnover magnitudes of the luminosity functions of the blue (metal-poor) GCs (0.70 < (V − I) ≤ 1.05) in the halo are estimated V(max) = 27.11 ± 0.09 mag and I(max) = 26.21 ± 0.11 mag. We obtain similar values for NGC 4923, a companion S0 galaxy, and two Coma cD galaxies (NGC 4874 and NGC 4889). The mean value for the turnover magnitudes of these four galaxies is I(max) = 26.25 ± 0.03 mag. Adopting M{sub I} (max) = −8.56 ± 0.09 mag for the metal-poor GCs, we determine the mean distance to the four Coma galaxies to be 91 ± 4 Mpc. Combining this with the Coma radial velocity, we derive a value of the Hubble constant, H{sub 0} = 77.9 ± 3.6 km s{sup −1} Mpc{sup −1}. We estimate the GC specific frequency of NGC 4921 to be S{sub N} = 1.29 ± 0.25, close to the values for early-type galaxies. This indicates that NGC 4921 is in the transition phase to S0s.

  1. Deep Galex Observations of the Coma Cluster: Source Catalog and Galaxy Counts

    Science.gov (United States)

    Hammer, D.; Hornschemeier, A. E.; Mobasher, B.; Miller, N.; Smith, R.; Arnouts, S.; Milliard, B.; Jenkins, L.

    2010-01-01

    We present a source catalog from deep 26 ks GALEX observations of the Coma cluster in the far-UV (FUV; 1530 Angstroms) and near-UV (NUV; 2310 Angstroms) wavebands. The observed field is centered 0.9 deg. (1.6 Mpc) south-west of the Coma core, and has full optical photometric coverage by SDSS and spectroscopic coverage to r-21. The catalog consists of 9700 galaxies with GALEX and SDSS photometry, including 242 spectroscopically-confirmed Coma member galaxies that range from giant spirals and elliptical galaxies to dwarf irregular and early-type galaxies. The full multi-wavelength catalog (cluster plus background galaxies) is 80% complete to NUV=23 and FUV=23.5, and has a limiting depth at NUV=24.5 and FUV=25.0 which corresponds to a star formation rate of 10(exp -3) solar mass yr(sup -1) at the distance of Coma. The GALEX images presented here are very deep and include detections of many resolved cluster members superposed on a dense field of unresolved background galaxies. This required a two-fold approach to generating a source catalog: we used a Bayesian deblending algorithm to measure faint and compact sources (using SDSS coordinates as a position prior), and used the GALEX pipeline catalog for bright and/or extended objects. We performed simulations to assess the importance of systematic effects (e.g. object blends, source confusion, Eddington Bias) that influence source detection and photometry when using both methods. The Bayesian deblending method roughly doubles the number of source detections and provides reliable photometry to a few magnitudes deeper than the GALEX pipeline catalog. This method is also free from source confusion over the UV magnitude range studied here: conversely, we estimate that the GALEX pipeline catalogs are confusion limited at NUV approximately 23 and FUV approximately 24. We have measured the total UV galaxy counts using our catalog and report a 50% excess of counts across FUV=22-23.5 and NUV=21.5-23 relative to previous GALEX

  2. 脑电双频指数在监测重度颅脑损伤合并顽固性颅内高压患者的巴比妥盐昏迷中的应用%The Use of Bispectral Index to Monitor Barbiturate Coma in Severely Brain-Injured Patients with Refractory Intracranial Hypertension

    Institute of Scientific and Technical Information of China (English)

    Vincent Cottenceau; 沙欢欢; Laurent Petit; Fran(c)oise Masson; Dominique Guehl; Julien Asselineau; Jean-Fran(c)ois Cochard; Catherine Pinaquy; Alain Leger; Fran(c)ois Sztark

    2010-01-01

    背景在重症创伤性颅脑损伤(TBI)患者运用巴比妥盐治疗中,通常将暴发-抑制模式的脑电图(EEG)作为监测指标.双频指数(BIS)是脑电图的衍生物,并且考虑到了皮层电静止.本研究测定一定范围内的BIS是否可以预测一个特殊的暴发-抑制模式.方法前瞻性收入l1例应用巴比妥盐治疗的TBI患者.每天记录1小时EEG,每5分钟从原始EEG上计算1分钟的暴发数量及抑制率[抑制率(SREEG):从EEG上得到的前60秒皮层电静止所占的百分率],并与BIS-XPTM监测仪上伴行的数据对比[BIS和抑制商(SRBIS)].巴比妥盐昏迷的最佳水平定义为脑电图上每分钟有2~5个暴发发生.根据所得数据求出最佳水平的BIS预测值范围,对每一例数据都测定其精确度.结果 SREEG和SRBIS一致性很高[组间相关系数0.94(95%可信区间:0.90~0.96)].SREEG和BIS之间有显著相关性.在某些受试者中观察到显著不一致性.BIS值在6~15范围之间时预测精确度最高.结论应用巴比妥盐治疗的重症创伤性颅脑损伤患者,BIS和SREEG有很高相关性.当BIS值<6时巴比妥盐输注速率需要降低,而当BIS值>15时,则需要升高.BIS和抑制图形的关系应该周期性地通过EEG模拟信号(BIS-XPTM所示)来校正.

  3. Nursing Experience of Severe Brain Trauma Coma Patients%重症脑外伤昏迷患者的护理体会

    Institute of Scientific and Technical Information of China (English)

    薛明琴

    2014-01-01

    Objective To explore ef icient nursing methods for coma patients with severe brain contusion. Methods 32 cases of severe brain contusion patients were selected. During the therapy session, they experienced a series of nursing process, including careful disease observation, ef icient basic nursing, airway management, hyperbaric oxygen therapy and rehabilitation nursing. The nursing ef ects are carefully compared and analyzed. Results Through treatment and nurse care, 12 patients were total y cured and 18 patients turned bet er. The curative rate is 94%. Conclusion The effective nursing procedure is a significant process of preventing complications and reducing the possibilities of disability for severe brain contusion patients.%目的探讨重症脑外伤昏迷患者的合理有效的护理方法。方法对32例重症脑外伤昏迷患者进行严密的病情观察、有效的基础护理、气道管理、高压氧治疗的护理、康复护理。结果经过治疗和护理,治愈12例,好转18例,治愈好转率占94%。结论有效的护理是预防并发症,降低致残率的重要环节。

  4. Mt. Wendelstein imaging of the post-perihelion dust coma of 67P/Churyumov–Gerasimenko in 2015/2016

    Science.gov (United States)

    Boehnhardt, Hermann; Riffeser, Arno; Kluge, Matthias; Ries, Christoph; Schmidt, Michael; Hopp, Ulrich

    2016-11-01

    Comet 67P/Churyumov-Gerasimenko (67P) was imaged with the 2 m telescope at Mt. Wendelstein Observatory in the Alps. Coma and tail monitoring was performed during 51 nights between 2015 August 22 and 2016 May 9. The images through r and i Sloan Digital Sky Survey (SDSS) filters show the dust distribution around the comet, while images in the SDSS g filter also indicate the presence of coma gas in early 2015 September. The dust colour of 67P implies intrinsic reddening of 9 per cent/100 nm. After maximum, shortly after perihelion passage, the dust activity decreased with a heliocentric exponent of 4.1-4.2 from late 2015 September until 2016 May. The opposition surge during early 2016 can be explained by a linear light scattering phase function (β ˜ 0.04) or an asteroid-like HG-type phase function (G ˜ 0.15). The radial brightness profile indicates a `quasi-steady-state' dust coma from late September to the end of 2015. Dust fragmentation during about a month after perihelion may be responsible for radial coma profiles with slopes below unity, while dust accumulation due to very slow dust expansion velocity may result in steeper than unity profiles during 2016. Three fan-shape dust structures are characterized in the coma of 67P. A short dust ejection event on 2015 August 22-23 has produced a dust arc-let and jet feature in the coma. In 2015 September, the appearance of cometary dust tail is dominated by the young dust produced around perihelion. The older dust dominates the tail appearance as of 2015 mid-November.

  5. The Asymmetric Coma of Comets. I. Asymmetric Outgassing from the Nucleus of Comet 2P/Encke

    Science.gov (United States)

    Festou, M. C.; Barale, O.

    2000-06-01

    Very little is known about how outgassing regions are distributed over the nucleus of comets. In periodic comets, active regions are believed to be few and of small extent. Since periodic comets are notorious for their lack of (small) solid particles that efficiently scatter sunlight, we try to find traces of the existence of production sites by examining the morphology of the gas coma. We use a new coma model in which results from hydrodynamics calculations describing the inner coma are used as limit conditions for a collisionless description of the outer coma. The production pattern of the parent species mainly depends on the extent and location of the production region(s) and on the rotational state of the nucleus. Analyzing 1980 observations of comet 2P/Encke, we find that free emission from a single, small, active region located near the subsolar point of a nonrotating nucleus is excluded. But such an active region on a rotating nucleus produces well the observed coma morphology. Our data then allow us to determine the orientation of the comet spin axis and the cometocentric latitude of the source. Emission from a few small production regions spread over the sunward part of a nonrotating nucleus or emission at a very low rate from a larger subsolar area could also fit the data. Although we do not find a unique solution to our problem, the excellent quality of our fits indicates that our approach, if used with enough care, can provide a new tool to investigate the properties of comet nuclei when the coma is far from spherically symmetric and, ultimately, to study the effects of the nongravitational force that is acting on comet nuclei.

  6. CometCIEF: A Web-based Image Enhancement Facility to digitally enhance images of cometary comae

    Science.gov (United States)

    Samarasinha, N.; Martin, P.; Larson, S.

    2014-07-01

    The detailed analysis of cometary comae provides an observational basis to investigate both the nucleus as well as the coma of comets. The structures in the coma are indicative of the anisotropic emission of gas and dust from the nucleus. Therefore, accurate identifications and measurements of spatial information related to coma structures are needed for realistic quantitative interpretation of coma observations. In many instances, the coma features are only a few percent above the ambient background coma and require enhancement of such features to unambiguously identify them, to make measurements on them, and to carry out subsequent detailed analyses. There is a number of image enhancement techniques used by cometary scientists. Despite this, the wider applicability of many advanced enhancement techniques is limited due to the non-availability of relevant software as open source. To alleviate this, we are making available a number of such techniques using a user-friendly web interface. In this image enhancement facility available at http://www.psi.edu/research/cometimen one can upload a fits format image of a cometary coma and digitally enhance it using an image enhancement technique of the user's choice. The user can then easily download the enhanced image as well as any associated images generated during the enhancement as fits files for detailed analysis later at the user's institution. The available image enhancement techniques at the facility are: (a) division by azimuthal average; (b) division by azimuthal median; (c) azimuthal renormalization; (d) division by 1/ρ profile, where ρ is the sky-plane projected distance from the nucleus; and (e) radially variable spatial filtering. The site provides documentation describing the above enhancement techniques as well as a tutorial showing the application of the enhancement techniques to actual cometary images and how the results may vary with different input parameters. In addition, the source codes as well as

  7. THE REINCARNATION OF INTERSTELLAR DUST: THE IMPORTANCE OF ORGANIC REFRACTORY MATERIAL IN INFRARED SPECTRA OF COMETARY COMAE AND CIRCUMSTELLAR DISKS

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, Hiroshi, E-mail: hiroshi_kimura@cps-jp.org [Graduate School of Science, Kobe University, c/o CPS (Center for Planetary Science), Chuo-ku Minatojima Minamimachi 7-1-48, Kobe 650-0047 (Japan)

    2013-09-20

    We consider the reincarnation of interstellar dust to be reborn in protoplanetary disks as aggregates consisting of submicron-sized grains with a crystalline or amorphous silicate core and an organic-rich carbonaceous mantle. We find that infrared spectra of reincarnated interstellar dust reproduce emission peaks at correct wavelengths where the peaks were observed in cometary comae, debris disks, and protoplanetary disks if the volume fraction of organic refractory meets the constraints on elemental abundances. We discuss what we can learn from the infrared spectra of reincarnated interstellar dust in cometary comae and circumstellar disks.

  8. The Reincarnation of Interstellar Dust: The Importance of Organic Refractory Material in Infrared Spectra of Cometary Comae and Circumstellar Disks

    Science.gov (United States)

    Kimura, Hiroshi

    2013-09-01

    We consider the reincarnation of interstellar dust to be reborn in protoplanetary disks as aggregates consisting of submicron-sized grains with a crystalline or amorphous silicate core and an organic-rich carbonaceous mantle. We find that infrared spectra of reincarnated interstellar dust reproduce emission peaks at correct wavelengths where the peaks were observed in cometary comae, debris disks, and protoplanetary disks if the volume fraction of organic refractory meets the constraints on elemental abundances. We discuss what we can learn from the infrared spectra of reincarnated interstellar dust in cometary comae and circumstellar disks.

  9. INTEGRAL/IBIS deep extragalactic survey: M81, LMC and 3C 273/Coma fields

    CERN Document Server

    Mereminskiy, Ilya A; Lutovinov, Alexander A; Sazonov, Sergey Yu; Revnivtsev, Mikhail G; Sunyaev, Rashid A

    2016-01-01

    We present results of deep surveys of three extragalactic fields, M81 (exposure of 9.7 Ms), LMC (6.8 Ms) and 3C 273/Coma (9.3 Ms), in the hard X-ray (17-60 keV) energy band with the IBIS telescope onboard the INTEGRAL observatory, based on 12 years of observations (2003-2015). The combined survey reaches a $4\\sigma$ peak sensitivity of 0.18 mCrab (2.6$\\times$10$^{-12}$ erg s$^{-1}$ cm$^{-2}$) and sensitivity better than 0.25 and 0.87 mCrab over 10% and 90% of its full area of 4900 deg$^{2}$, respectively. We have detected in total 147 sources at $S/N>4\\sigma$, including 37 sources observed in hard X-rays for the first time. The survey is dominated by extragalactic sources, mostly by active galactic nuclei (AGN). The sample of identified sources contains 98 AGN (including 64 Seyfert galaxies, 7 LINERs, 3 XBONGs, 16 blazars and 8 AGN of unclear optical class), two galaxy clusters (Coma and Abell 3266), 17 objects located in the Large and Small Magellanic Clouds (13 high- and 2 low-mass X-ray binaries and 2 X-ra...

  10. Dark energy and the structure of the Coma cluster of galaxies

    CERN Document Server

    Chernin, A D; Teerikorpi, P; Valtonen, M J; Byrd, G G; Merafina, M

    2013-01-01

    {We consider the Coma cluster of galaxies as a gravitationally bound physical system embedded in the perfectly uniform static dark energy background as implied by the $\\Lambda$CDM cosmology.} {We ask if the density of dark energy is high enough to affect the structure of a large rich cluster of galaxies?} {We use recent observational data on the cluster together with our theory of local dynamical effects of dark energy, including the zero-gravity radius $R_{\\rm ZG}$ of the local force field as the key parameter.} {1) Three masses are defined which characterize the structure of a regular cluster: the matter mass $M_{\\rm M}$, the dark-energy effective mass $M_{\\rm DE}$ ($<0$) and the gravitating mass $M_{\\rm G}$ ($= M_{\\rm M} + M_{\\rm DE}$). 2) A new matter density profile is suggested which reproduces well the observational data for the Coma cluster in the radius range from 1.4 Mpc to 14 Mpc and takes into account the dark energy background. 3) Using this profile, we calculate upper limits for the total siz...

  11. X-Ray surface brightness and gas density fluctuations in the Coma cluster

    CERN Document Server

    Churazov, E; Zhuravleva, I; Schekochihin, A; Parrish, I; Sunyaev, R; Forman, W; Boehringer, H; Randall, S

    2011-01-01

    X-ray surface brightness fluctuations in the core ($650 \\times 650$ kpc) region of the Coma cluster observed with XMM-Newton and Chandra are analyzed using a 2D power spectrum approach. The resulting 2D spectra are converted to 3D power spectra of gas density fluctuations. The characteristic amplitude of the volume filling density fluctuations relative to the smooth underlying density distribution varies from 7-10% on scales of $\\sim$500 kpc down to $\\sim$5% at scales $\\sim$ 30 kpc. On smaller spatial scales, projection effects smear the density fluctuations by a large factor, precluding strong limits on the fluctuations in 3D. On the largest scales probed (hundreds of kpc), the dominant contributions to the observed fluctuations most likely arise from perturbations of the gravitational potential by the two most massive galaxies in Coma, NGC4874 and NGC4889, and the low entropy gas brought to the cluster by an infalling group. Other plausible sources of density fluctuations are discussed, including turbulence...

  12. MITO measurements of the Sunyaev-Zeldovich Effect in the Coma cluster of galaxies

    CERN Document Server

    De Petris, M; Lamagna, L; Melchiorri, F; Orlando, A E; Palladino, E; Rephaeli, Y; Colafrancesco, Sergio; Kreysa, E; Signore, M

    2002-01-01

    We have measured the Sunyaev-Zeldovich effect towards the Coma cluster (A1656) with the MITO experiment, a 2.6-m telescope equipped with a 4-channel 17 arcminute (FWHM) photometer. Measurements at frequency bands 143+/-15, 214+/-15, 272+/-16 and 353+/-13 GHz, were made during 120 drift scans of Coma. We describe the observations and data analysis that involved extraction of the S-Z signal by employing a spatial and spectral de-correlation scheme to remove a dominant atmospheric component. The deduced values of the thermal S-Z effect in the first three bands are DT_{0} = -179+/-38,-33+/-81,170+/-35 microKelvin in the cluster center. The corresponding optical depth, tau=(4.1+/-0.9) 10^{-3}, is consistent (within errors) with both the value from a previous low frequency S-Z measurement, and the value predicted from the X-ray deduced gas parameters.

  13. Multiaperture U BV RIzJHK Photometry of Galaxies in the Coma Cluster

    Energy Technology Data Exchange (ETDEWEB)

    Eisenhardt, P R; De Propris, R; Gonzalez, A H; Stanford, S A; Dickinson, M; Wang, M C

    2006-12-05

    We present a set of UBV RIzJHKs photometry for 745 J +H band selected objects in a 22:5{prime} x 29:2{prime} region centered on the core of the Coma cluster. This includes 516 galaxies and is at least 80% complete to H = 16, with a spectroscopically complete sample of 111 cluster members (nearly all with morphological classification) for H < 14:5. For each object we present total Kron (1980) magnitudes and aperture photometry. As an example, we use these data to derive color-magnitude relations for Coma early-type galaxies, measure the intrinsic scatter of these relations and its dependence on galaxy mass, and address the issue of color gradients. We find that the color gradients are mild and that the intrinsic scatter about the color-magnitude relation is small ({approx} 0:05 mag in U-V and less than {approx} 0:03 in B-R, V-I, or J-K). There is no evidence that the intrinsic scatter varies with galaxy luminosity, suggesting that the cluster red sequence is established at early epochs over a range of {approx} 100 in stellar mass.

  14. Ginga observations of the Coma cluster and studies of the spatial distribution of iron

    Science.gov (United States)

    Hughes, John P.; Butcher, Jackie A.; Stewart, Gordon C.; Tanaka, Yasuo

    1993-01-01

    The large area counters on the Japanese satellite Ginga have been used to determine the X-ray spectrum from the central region of the Coma cluster of galaxies over the energy range from 1.5 to 20 keV. The spectrum is well represented by an isothermal model of temperature 8.21 +/- 0.16 keV and a heavy element (iron) abundance of 0.212 +/- 0.027, relative to the cosmic value. The Ginga spectrum was found to be consistent with the X-ray spectra from the Tenma and EXOSAT satellites for a large class of nonisothermal temperature distributions. The measured iron elemental abundances were used to set a lower limit on the total mass of iron in Coma under the assumption that the iron is not distributed uniformly throughout the cluster. The mass ratio of iron relative to hydrogen (within 2 Mpc) is not less than 18 percent of the cosmic iron to hydrogen mass ratio. This compares to an average abundance of 24 percent if the iron is distributed uniformly. We discuss these results in terms of models for the production of iron in galaxy clusters.

  15. The EUV Emission in the Coma Cluster of Galaxies and the Underlying Source of this Radiation

    CERN Document Server

    Bowyer, S; Lampton, M; Jones, T W

    2004-01-01

    Observations with the Extreme Ultraviolet Explorer (EUVE) have shown the Coma Cluster to be a source of EUV emission in excess of that produced by X-ray gas in the cluster. We have re-examined the EUVE data on this cluster in an attempt to obtain clues as to the origin of this emission. We find two important new results. First, the ratio between the azimuthally averaged EUV excess emission and the ROSAT hard X-ray flux is constant as a function of distance from the cluster center outward. Second, a correlation analysis between the EUV excess emission and the X-ray emission shows that on a detailed level the EUV excess is spatially closely related to the X-ray emission. These findings contradict previous suggestions as to the underlying source of the diffuse EUV emission in Coma and provide important information in regards to the true source of this emission. We propose a new explanation for the source of this emission: inverse Compton scattering of microwave background photons by secondary electrons and posit...

  16. Constraints on diffuse gamma-ray emission from structure formation processes in the Coma cluster

    CERN Document Server

    Zandanel, Fabio

    2013-01-01

    We analyze the 5-year (63 months) data of Large Area Telescope on board Fermi satellite from the Coma galaxy cluster in the energy range between 100 MeV and 100 GeV. The likelihood analyses are performed with several model templates. We consider (1) a point source; (2) models motivated by cosmological hydrodynamical simulations that predict a dominant pion-decay-induced gamma-ray emission from cosmic ray proton-proton interaction with the cluster ambient gas; (3) a phenomenological template based on the cluster radio relic to test the possible associated inverse-Compton scattering of the relic electrons off the cosmic microwave background; and (4) both a disk and ring-like emission profiles to test the inverse-Compton emission from primary electrons accelerated at accreting shocks. We find no excess emission for any of these models, and derive the most stringent constraints to date on the Coma cluster above 100 MeV, and on the tested scenarios in general. The upper limits on the integral flux range from 10^-1...

  17. The main-sequence rotation-colour relation in the Coma Berenices open cluster

    CERN Document Server

    Cameron, A Collier; Hebb, L; Skinner, G; Anderson, D R; Christian, D J; Clarkson, W I; Enoch, B; Irwin, J; Joshi, Y; Haswell, C A; Hellier, C; Horne, K D; Kane, S R; Lister, T A; Maxted, P F L; Norton, A J; Parley, N; Pollacco, D; Ryans, R; Scholz, A; Skillen, I; Smalley, B; Street, R A; West, R G; Wilson, D M; Wheatley, P J

    2009-01-01

    We present the results of a photometric survey of rotation rates in the Coma Berenices (Melotte 111) open cluster, using data obtained as part of the SuperWASP exoplanetary transit-search programme. The goal of the Coma survey was to measure precise rotation periods for main-sequence F, G and K dwarfs in this intermediate-age (~600 Myr) cluster, and to determine the extent to which magnetic braking has caused the stellar spin periods to converge. We find a tight, almost linear relationship between rotation period and J-K colour with a root-mean square scatter of only 2 percent. The relation is similar to that seen among F, G and K stars in the Hyades. Such strong convergence can only be explained if angular momentum is not at present being transferred from a reservoir in the deep stellar interiors to the surface layers. We conclude that the coupling timescale for angular momentum transport from a rapidly-spinning radiative core to the outer convective zone must be substantially shorter than the cluster age, a...

  18. Planck Intermediate Results. X. Physics of the hot gas in the Coma cluster

    CERN Document Server

    Ade, P A R; Arnaud, M; Ashdown, M; Atrio-Barandela, F; Aumont, J; Baccigalupi, C; Balbi, A; Banday, A J; Barreiro, R B; Bartlett, J G; Battaner, E; Benabed, K; Benoît, A; Bernard, J -P; Bersanelli, M; Bonaldi, A; Bond, J R; Borrill, J; Bouchet, F R; Bourdin, H; Brown, M L; Burigana, C; Cabella, P; Cardoso, J -F; Carvalho, P; Catalano, A; Cayón, L; Chiang, L -Y; Chon, G; Christensen, P R; Churazov, E; Clements, D L; Colafrancesco, S; Colombo, L P L; Coulais, A; Crill, B P; Cuttaia, F; Da Silva, A; Dahle, H; Danese, L; Davis, R J; de Bernardis, P; de Gasperis, G; de Rosa, A; de Zotti, G; Delabrouille, J; Désert, F -X; Dickinson, C; Diego, J M; Dolag, K; Dole, H; Donzelli, S; Doré, O; Dörl, U; Douspis, M; Dupac, X; Enßlin, T A; Eriksen, H K; Finelli, F; Flores-Cacho, I; Forni, O; Frailis, M; Franceschi, E; Frommert, M; Galeotta, S; Ganga, K; Génova-Santos, R T; Giard, M; Gilfanov, M; González-Nuevo, J; Górski, K M; Gregorio, A; Gruppuso, A; Hansen, F K; Harrison, D; Henrot-Versillé, S; Hernández-Monteagudo, C; Hildebrandt, S R; Hivon, E; Hobson, M; Holmes, W A; Hornstrup, A; Hovest, W; Huffenberger, K M; Hurier, G; Jaffe, T R; Jagemann, T; Jones, W C; Juvela, M; Keihänen, E; Kneissl, R; Knoche, J; Knox, L; Kunz, M; Kurki-Suonio, H; Lagache, G; Lähteenmäki, A; Lasenby, A; Lawrence, C R; Jeune, M Le; Leonardi, R; Lilje, P B; Linden-Vørnle, M; López-Caniego, M; Lubin, P M; Macías-Pérez, J F; Maffei, B; Maino, D; Mandolesi, N; Maris, M; Marleau, F; Martínez-González, E; Masi, S; Massardi, M; Matarrese, S; Matthai, F; Mazzotta, P; Mei, S; Melchiorri, A; Melin, J -B; Mendes, L; Mennella, A; Mitra, S; Miville-Deschênes, M -A; Moneti, A; Montier, L; Morgante, G; Munshi, D; Murphy, J A; Naselsky, P; Natoli, P; Nørgaard-Nielsen, H U; Noviello, F; Osborne, S; Pajot, F; Paoletti, D; Perdereau, O; Perrotta, F; Piacentini, F; Piat, M; Pierpaoli, E; Piffaretti, R; Plaszczynski, S; Pointecouteau, E; Polenta, G; Ponthieu, N; Popa, L; Poutanen, T; Pratt, G W; Prunet, S; Puget, J -L; Rachen, J P; Rebolo, R; Reinecke, M; Remazeilles, M; Renault, C; Ricciardi, S; Riller, T; Rocha, G; Roman, M; Rosset, C; Rossetti, M; Rubiño-Martín, J A; Rusholme, B; Sandri, M; Savini, G; Schaefer, B M; Scott, D; Smoot, G F; Stivoli, F; Sudiwala, R; Sunyaev, R; Sutton, D; Suur-Uski, A -S; Sygnet, J -F; Tauber, J A; Terenzi, L; Toffolatti, L; Tomasi, M; Tristram, M; Tuovinen, J; Türler, M; Umana, G; Valenziano, L; Van Tent, B; Varis, J; Vielva, P; Villa, F; Vittorio, N; Wade, L A; Wandelt, B D; Welikala, N; White, S D M; Yvon, D; Zacchei, A; Zaroubi, S; Zonca, A

    2012-01-01

    We present an analysis of Planck satellite data on the Coma Cluster observed via the Sunyaev-Zeldovich effect. Planck is able, for the first time, to detect SZ emission up to r ~ 3 X R_500. We test previously proposed models for the pressure distribution in clusters against the azimuthally averaged data. We find that the Arnaud et al. universal pressure profile does not fit Coma, and that their pressure profile for merging systems provides a good fit of the data only at rR_500 than the mean pressure profile predicted by the simulations. The Planck image shows significant local steepening of the y profile in two regions about half a degree to the west and to the south-east of the cluster centre. These features are consistent with the presence of shock fronts at these radii, and indeed the western feature was previously noticed in the ROSAT PSPC mosaic by Markevitch (2000) as well as in the radio. Using Planck y profiles extracted from corresponding sectors we find pressure jumps of 4.5+2.5-0.1 and 4.9+0.7-0.2 ...

  19. Ion chemistry in the coma of comet 67P near perihelion

    Science.gov (United States)

    Fuselier, S. A.; Altwegg, K.; Balsiger, H.; Berthelier, J. J.; Beth, A.; Bieler, A.; Briois, C.; Broiles, T. W.; Burch, J. L.; Calmonte, U.; Cessateur, G.; Combi, M.; De Keyser, J.; Fiethe, B.; Galand, M.; Gasc, S.; Gombosi, T. I.; Gunell, H.; Hansen, K. C.; Hässig, M.; Heritier, K. L.; Korth, A.; Le Roy, L.; Luspay-Kuti, A.; Mall, U.; Mandt, K. E.; Petrinec, S. M.; Rème, H.; Rinaldi, M.; Rubin, M.; Sémon, T.; Trattner, K. J.; Tzou, C.-Y.; Vigren, E.; Waite, J. H.; Wurz, P.

    2016-11-01

    The coma and the comet-solar wind interaction of comet 67P/Churyumov-Gerasimenko changed dramatically from the initial Rosetta spacecraft encounter in 2014 August through perihelion in 2015 August. Just before equinox (at 1.6 au from the Sun), the solar wind signal disappeared and two regions of different cometary ion characteristics were observed. These `outer' and `inner' regions have cometary ion characteristics similar to outside and inside the ion pileup region observed during the Giotto approach to comet 1P/Halley. Rosetta/Double-Focusing Mass Spectrometer ion mass spectrometer observations are used here to investigate the H3O+/H2O+ ratio in the outer and inner regions at 67P/ Churyumov-Gerasimenko. The H3O+/H2O+ ratio and the H3O+ signal are observed to increase in the transition from the outer to the inner region and the H3O+ signal appears to be weakly correlated with cometary ion energy. These ion composition changes are similar to the ones observed during the 1P/Halley flyby. Modelling is used to determine the importance of neutral composition and transport of neutrals and ions away from the nucleus. This modelling demonstrates that changes in the H3O+/H2O+ ratio appear to be driven largely by transport properties and only weakly by neutral composition in the coma.

  20. DRY MERGER RATE AND POST-MERGER FRACTION IN THE COMA CLUSTER CORE

    Energy Technology Data Exchange (ETDEWEB)

    Cordero, Juan P.; Campusano, Luis E.; Haines, Christopher P. [Departamento de Astronomía, Universidad de Chile, Casilla 36-D, Santiago (Chile); De Propris, Roberto [Finnish Centre for Astronomy with ESO, University of Turku, Vaisalantie 20, Piikkio, FI-21500 (Finland); Weinzirl, Tim [School of Physics and Astronomy, The University of Nottingham, University Park, Nottingham NG7 2RD (United Kingdom); Jogee, Shardha, E-mail: jcordero@das.uchile.cl [Department of Astronomy, The University of Texas at Austin, Austin, TX 78712-1205 (United States)

    2016-01-20

    We evaluate the dry merger activity in the Coma cluster, using a spectroscopically complete sample of 70 red-sequence (RS) galaxies, most of which (∼75%) are located within 0.2R{sub 200} (∼0.5 Mpc) from the cluster center, with data from the Coma Treasury Survey obtained with the Hubble Space Telescope. The fraction of close galaxy pairs in the sample is the proxy employed for the estimation of the merger activity. We identify 5 pairs and 1 triplet, enclosing a total of 13 galaxies, based on limits on projected separation and line-of-sight velocity difference. Of these systems, none show signs of ongoing interaction, and therefore we do not find any true mergers in our sample. This negative result sets a 1σ upper limit of 1.5% per Gyr for the major dry merger rate, consistent with the low rates expected in present-day clusters. Detailed examination of the images of all the RS galaxies in the sample reveals only one with low surface brightness features identifiable as the remnant of a past merger or interaction, implying a post-merger fraction below 2%.

  1. A New Distance Measurement to NGC 4874 in the Coma Cluster

    Science.gov (United States)

    Bartier, Crystal-Lynn; Jensen, Joseph; Blakeslee, John

    2017-01-01

    By measuring distances to remote galaxies we can determine the size, expansion rate, and age of the Universe. One of the best ways to measure distance is known as surface brightness fluctuations (SBF). The purpose of this research is to improve the current distance to the Coma Cluster by making accurate SBF distance measurements to two galaxies, NGC 4874 and NGC 4921. We analyzed HST WFC3 images in the F110W and F160W bands for NGC 4874 and ACS F814W and F606W for NGC 4921. Although NGC 4921 has a Cepheid distance measurement, we were unable to make an SBF measurement to NGC 4921 due to the presence of dust and young stars. The results of the distance measurement to NGC 4874 will be compared with previous distance measurements for the Coma Cluster. We also present a comparison of the globular cluster luminosity function for NGC 4874 measured using Source Extractor and a modified version of Dophot to help determine the photometric accuracy of our measurements in the presence of the bright galaxy background.

  2. Coma from wall suction-induced CSF leak complicating spinal surgery.

    Science.gov (United States)

    Fehnel, Corey R; Razmara, Ali; Feske, Steven K

    2014-03-12

    A 72-year-old woman was admitted for elective L4/L5 laminectomy. The operative procedure was extradural, and a Jackson-Pratt (JP) drain was placed in the tissue bed and set to wall suction during skin closure. During closure, the patient developed a 15 s period of asystole. The patient was haemodynamically stable, but was comatose for 3 days postoperatively. Cardiac enzymes and EEG were unrevealing. Head CT showed traces of subarachnoid haemorrhage and signs suggestive of cerebral anoxia. JP drain at the incision produced 170-210 mL/day of fluid, positive for β-2 transferrin, indicating cerebrospinal fluid (CSF). The patient fully returned to baseline on hospital day 10. MRI on hospital day 8 normalised. The reversible coma and radiographic findings were most consistent with acute intracranial hypotension relating to acute loss of CSF. Because radiographic findings can mimic hypoxic-ischaemic injury, acute intracranial hypotension should be considered in the differential diagnosis of postoperative coma after cranial or spinal surgery.

  3. Dry Merger Rate and Post-merger Fraction in the Coma Cluster Core

    CERN Document Server

    Cordero, Juan P; De Propris, Roberto; Haines, Christopher P; Weinzirl, Tim; Jogee, Shardha

    2016-01-01

    We evaluate the dry merger activity in the Coma cluster, using a spectroscopically complete sample of 70 red-sequence (RS) galaxies, most of which (~75%) are located within 0.2R200 (~0.5 Mpc) from the cluster center, with data from the Coma Treasury Survey obtained with the Hubble Space Telescope. The fraction of close galaxy pairs in the sample is the proxy employed for the estimation of the merger activity. We identify 5 pairs and 1 triplet, enclosing a total of 13 galaxies, based on limits on projected separation and line-of-sight velocity difference. Of these systems, none show signs of ongoing interaction, and therefore we do not find any true mergers in our sample. This negative result sets a 1{\\sigma} upper limit of 1.5% per Gyr for the major dry merger rate, consistent with the low rates expected in present-day clusters. Detailed examination of the images of all the RS galaxies in the sample reveals only one with low surface brightness features identifiable as the remnant of a past merger or interacti...

  4. Reversible coma and Duret hemorrhage after intracranial hypotension from remote lumbar spine surgery: case report.

    Science.gov (United States)

    Bonow, Robert H; Bales, James W; Morton, Ryan P; Levitt, Michael R; Zhang, Fangyi

    2016-03-01

    Intracranial hypotension is a rare condition caused by spontaneous or iatrogenic CSF leaks that alter normal CSF dynamics. Symptoms range from mild headaches to transtentorial herniation, coma, and death. Duret hemorrhages have been reported to occur in some patients with this condition and are traditionally believed to be associated with a poor neurological outcome. A 73-year-old man with a remote history of spinal fusion presented with syncope and was found to have small subdural hematomas on head CT studies. He was managed nonoperatively and discharged with a Glasgow Coma Scale score of 15, only to return 3 days later with obtundation, fixed downward gaze, anisocoria, and absent cranial nerve reflexes. A CT scan showed Duret hemorrhages and subtle enlargement of the subdural hematomas, though the hematomas remained too small to account for his poor clinical condition. Magnetic resonance imaging of the spine revealed a large lumbar pseudomeningocele in the area of prior fusion. His condition dramatically improved when he was placed in the Trendelenburg position and underwent repair of the pseudomeningocele. He was kept flat for 7 days and was ultimately discharged in good condition. On long-term follow-up, his only identifiable deficit was diplopia due to an internuclear ophthalmoplegia. Intracranial hypotension is a rare condition that can cause profound morbidity, including tonsillar herniation and brainstem hemorrhage. With proper identification and treatment of the CSF leak, patients can make functional recoveries.

  5. Distributed coma sources and the CH sub 4 /CO ratio in Comet Halley

    Energy Technology Data Exchange (ETDEWEB)

    Boice, D.C. (Southwest Research Inst., San Antonio, TX (USA) Max-Planck-Inst. fuer Astrophysik, Garching (West Germany)); Huebner, W.F.; Sablik, M.J.; Konno, I. (Southwest Research Inst., San Antonio, TX (USA))

    1990-10-01

    Early analyses of the Ion Mass Spectrometer (IMS) data from the Giotto flyby of Comet P/Halley indicated significant abundances of Ch{sup +}{sub n} (n=1 to 4). The source of these ions was assumed to be frozen CH{sub 4} in the nucleus. An abundance of about 2% Ch{sub 4} was consistent with this interpretation, resulting in a ratio of CH{sub 4}/CO that is greater than the predicted limits for interstellar clouds or the solar nebula. However, subsequent analyses of data from the Giotto Neutral Mass Spectrometer (NMS) indicate distributed sources of CO and H{sub 2}CO in the coma that are most likely associated with organic (CHON) particles, rich in CH-bearing compounds that decay and produce CH{sup +}{sub n} species. The authors present a model that qualitatively accounts for the measured spatial distribution of CO and H{sub 2}CO and indicates that most of the CH{sup +}{sub n} deduced from the Giotto IMS data may originate from organic compounds in the coma dust and not from volatiles released directly from the nucleus. As a consequence, the absence of CH{sub 4} in the icy phase of the nucleus is consistent with the observations with an upper limit of about 0.5% to the ratio CH{sub 4}/CO. This is an important criterion for theories of comet formation.

  6. The "near-death experience" during comas: psychotraumatic suffering or the taming of reality?

    Science.gov (United States)

    Auxéméry, Y

    2013-09-01

    An near death experience (NDE) is the experience of an atypical state of consciousness that is induced by the neuropsychological consequences of a passage near death. Far from being a psychologically traumatic event, these experiences never cause flashbacks and can even eliminate the fear of death. Listening to patients who have shared their near death sensations has encouraged the reevaluation of the medical standards associated with NDEs. Over several decades, the patient has been positioned at the center of management decisions, with his or her will taken into account. Certain patients can be revived following neurological events, but their resuscitation is performed with the possibility of serious neurological sequelae, which might prevent a return to normal life. The patient may also remain unconscious, either transiently or in a more long term coma or persistent vegetative state. Nonetheless, several works have demonstrated the presence of neuronal activity, however little, in patients suffering from prolonged comas. The medical team then does not act as if the patient were not there but, on the contrary, considers the patient to be the subject, although unable to speak directly, to whom one speaks and of whom one speaks between caregivers.

  7. Morphological classification and structural parameters for early-type galaxies in the Coma cluster

    CERN Document Server

    Andreon, S; Michard, R; Nieto, J L; Poulain, P

    1995-01-01

    We present the results of an isophotal shape analysis of three samples of galaxies in the Coma cluster. Quantitative morphology, together with structural and photometric parameters, is given for each galaxy. Special emphasis has been placed on the detailed classification of early-type galaxies. The three samples are: i) a sample of 97 early-type galaxies brighter than m_B = 17.00 falling within one degree from the center of the Coma cluster; these galaxies were observed with CCD cameras, mostly in good to excellent resolution conditions; ii) a magnitude complete sample of 107 galaxies of all morphological types down to m_B = 17.00 falling in a circular region of 50 arcmin diameter, slightly offcentered to the North-West of the cluster center; the images for this and the next sample come from digitized photographic plates; iii) a complete comparison sample of 26 galaxies of all morphological types down to m_R = 16.05 (or m_B \\simeq 17.5), also in a region of 50 arcmin diameter, but centered 2.6 degrees West of...

  8. Water Ice and Dust in the Innermost Coma of Comet 103P/Hartley 2

    CERN Document Server

    Protopapa, Silvia; Feaga, Lori M; Kelley, Michael S P; Hearn, Michael F A'; Farnham, Tony L; Groussin, Olivier; Besse, Sebastien; Merlin, Frederic; Li, Jian-Yang

    2014-01-01

    On November 4th, 2010, the Deep Impact eXtended Investigation (DIXI) successfully encountered comet 103P/Hartley 2, when it was at a heliocentric distance of 1.06 AU. Spatially resolved near-IR spectra of comet Hartley 2 were acquired in the 1.05-4.83 micron wavelength range using the HRI-IR spectrometer. We present spectral maps of the inner ~10 kilometers of the coma collected 7 minutes and 23 minutes after closest approach. The extracted reflectance spectra include well-defined absorption bands near 1.5, 2.0, and 3.0 micron consistent in position, bandwidth, and shape with the presence of water ice grains. Using Hapke's radiative transfer model, we characterize the type of mixing (areal vs. intimate), relative abundance, grain size, and spatial distribution of water ice and refractories. Our modeling suggests that the dust, which dominates the innermost coma of Hartley 2 and is at a temperature of 300K, is thermally and physically decoupled from the fine-grained water ice particles, which are on the order ...

  9. Communication opportunities via special messaging technology for two post-coma persons with multiple disabilities.

    Science.gov (United States)

    Lancioni, Giulio E; O'Reilly, Mark F; Singh, Nirbhay N; Sigafoos, Jeff; Buonocunto, Francesca; Sacco, Valentina; Colonna, Fabio; Navarro, Jorge; Lanzilotti, Crocifissa; de Pace, Claudia; Megna, Marisa; Oliva, Doretta

    2011-01-01

    This study extended the assessment of a special messaging technology with two additional post-coma adults who had emerged from a minimally conscious state, but showed multiple disabilities including profound motor and communication impairments. For each participant, the study involved an ABAB design, in which the A represented baseline phases and the B represented intervention phases with the special messaging technology. The technology involved a net-book computer provided with specific software, a global system for mobile communication (GSM) modem, microswitches, and prerecorded verbal lists of persons' names and messages. Both participants learned to send out and receive (listen to) messages independently during the intervention, thus providing clear support for previous data in the area. They sent out means of about three and 17 messages and received means of about two and six messages per 20- and 30-min session, respectively. The positive impact of the technology was discussed in relation to previous data in this area and the possibility of helping post-coma persons with multiple disabilities engage in basic communication with distant partners.

  10. A NuSTAR OBSERVATION OF THE CENTER OF THE COMA CLUSTER

    Energy Technology Data Exchange (ETDEWEB)

    Gastaldello, Fabio; Molendi, S. [IASF-Milano, INAF, Via Bassini 15, I-20133 Milan (Italy); Wik, Daniel R.; Zhang, W. W. [Astrophysics Science Division, NASA/Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Westergaard, N. J.; Hornstrup, A.; Ferreira, D. D. M.; Christensen, F. E. [DTU Space, National Space Institute, Technical University of Denmark, Elektrovej 327, DK-2800 Lyngby (Denmark); Madejski, G. [Kavli Institute for Particle Astrophysics and Cosmology, SLAC National Accelerator Laboratory, Menlo Park, CA 94025 (United States); Boggs, S. E.; Craig, W. W. [Space Sciences Laboratory, University of California, Berkeley, CA 94720 (United States); Grefenstette, B. W.; Harrison, F. A.; Madsen, K. K. [Cahill Center for Astronomy and Astrophysics, California Institute of Technology, Pasadena, CA 91125 (United States); Hailey, C. J. [Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027 (United States); Stern, D., E-mail: gasta@lambrate.inaf.it [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States)

    2015-02-20

    We present the results of a 55 ks NuSTAR observation of the core of the Coma Cluster. The global spectrum can be explained by thermal gas emission, with a conservative 90% upper limit to non-thermal inverse Compton (IC) emission of 5.1 × 10{sup –12} erg cm{sup –2} s{sup –1} in a 12' × 12' field of view. The brightness of the thermal component in this central region does not allow more stringent upper limits on the IC component when compared with non-imaging instruments with much larger fields of view where claims of detections have been made. Future mosaic NuSTAR observations of Coma will further address this issue. The temperature map shows a relatively uniform temperature distribution with a gradient from the hot northwest side to the cooler southeast, in agreement with previous measurements. The temperature determination is robust given the flat effective area and low background in the 3-20 keV band, making NuSTAR an ideal instrument to measure high temperatures in the intracluster medium.

  11. Distribution of Si, Fe, and Ni in the Intracluster Medium of the Coma Cluster

    CERN Document Server

    Matsushita, Kyoko; Sakuma, Eri; Sato, Kosuke

    2012-01-01

    We studied the distributions of Si, Fe, and Ni in the intracluster medium (ICM) of the Coma cluster, one of the largest clusters in the nearby universe, using XMM-Newton data up to 0.5 r180 and Suzaku data of the central region up to 0.16 r180. Using the flux ratios of Ly alpha of H-like Si and 7.8 keV blend to K alpha of He-like Fe, the abundance ratios of Si to Fe and Ni to Fe of the ICM were derived using APEC model v2.0.1. The Si/Fe ratio in the ICM of the Coma cluster shows no radial gradient. The emission weighted averages of the Si/Fe ratio in the ICM within 0.0--0.2 r180, 0.2--0.5 r180, and 0.0--0.5 r180 are 0.97 +- 0.11, 1.05 +- 0.36 and 0.99 +- 0.13, respectively, in solar units using the solar abundance of Lodders (2003). These values are close to those of smaller clusters and groups of galaxies. Using the Suzaku data of the central region, the derived Ni/Fe ratio of the ICM is 0.6--1.5 in solar units, according to the same solar abundance table. The systematic difference in the derived abundance r...

  12. Spectroscopic Confirmation of the Existence of Large, Diffuse Galaxies in the Coma Cluster

    CERN Document Server

    van Dokkum, Pieter; Abraham, Roberto; Brodie, Jean; Conroy, Charlie; Geha, Marla; Merritt, Allison; Villaume, Alexa; Zhang, Jielai

    2015-01-01

    We recently identified a population of low surface brightness objects in the field of the z=0.023 Coma cluster, using the Dragonfly Telephoto Array. Here we present Keck spectroscopy of one of the largest of these "ultra-diffuse galaxies" (UDGs), confirming that it is a member of the cluster. The galaxy has prominent absorption features, including the Ca II H+K lines and the G-band, and no detected emission lines. Its radial velocity of cz=6280 +- 120 km/s is within the 1 sigma velocity dispersion of the Coma cluster. The galaxy has an effective radius of 4.3 +- 0.3 kpc and a Sersic index of 0.89 +- 0.06, as measured from Keck imaging. We find no indications of tidal tails or other distortions, at least out to a radius of ~2 r_e. We show that UDGs are located in a previously sparsely populated region of the size - magnitude plane of quiescent stellar systems, as they are ~6 magnitudes fainter than normal early-type galaxies of the same size. It appears that the luminosity distribution of large quiescent galax...

  13. Forty-Seven Milky Way-Sized, Extremely Diffuse Galaxies in the Coma Cluster

    CERN Document Server

    van Dokkum, Pieter; Merritt, Allison; Zhang, Jielai; Geha, Marla; Conroy, Charlie

    2014-01-01

    We report the discovery of 47 low surface brightness objects in deep images of a 3 x 3 degree field centered on the Coma cluster, obtained with the Dragonfly Telephoto Array. The objects have central surface brightness mu(g,0) ranging from 24 - 26 mag/arcsec^2 and effective radii r_e = 3"-10", as measured from archival Canada France Hawaii Telescope images. From their spatial distribution we infer that most or all of the objects are galaxies in the Coma cluster. This relatively large distance is surprising as it implies that the galaxies are very large: with r_e = 1.5 - 4.6 kpc their sizes are similar to those of L* galaxies even though their median stellar mass is only ~6 x 10^7 Solar masses. The galaxies are relatively red and round, with = 0.8 and = 0.74. One of the 47 galaxies is fortuitously covered by a deep Hubble Space Telescope ACS observation. The ACS imaging shows a large spheroidal object with a central surface brightness mu(g,0) = 25.8 mag/arcsec^2, a Sersic index n=0.6, and an effective radius...

  14. Thermal SZ fluctuations in the ICM: probing turbulence and thermodynamics in Coma cluster with ${\\it Planck}$

    CERN Document Server

    Khatri, R

    2016-01-01

    The thermal Sunyaev-Zeldovich (SZ) ${\\it fluctuations}$ can open up a new powerful window into the astrophysics of the hot diffuse medium in cosmological structures. We report the detection of SZ fluctuations in the intracluster medium (ICM) of Coma cluster observed with ${\\it Planck}$. The SZ data links the maximum observable X-ray scale to the large Mpc scale, extending our knowledge of the power spectrum of ICM fluctuations. Deprojecting the 2-d SZ perturbations into 3-d pressure fluctuations, we find an amplitude spectrum which peaks at $\\delta P/P = 33\\pm 12\\%$ and $74\\pm19\\%$ in the $15'$ and $40'$ radius region, respectively. By using high-resolution hydrodynamical models, we improve the ICM turbulence constraints in Coma, finding 3-d Mach number ${\\rm Ma_{3d}}= 0.8\\pm0.3$ (15' region) and injection scale $L_{\\rm inj}\\approx 500$ kpc. Such properties are consistent with driving due to mergers tied to internal galaxy groups. For larger radii (40'), the injection scale is unaltered and the Mach number do...

  15. Dwarf Galaxies in the Coma Cluster: II. Spectroscopic and Photometric Fundamental Planes

    CERN Document Server

    Kourkchi, E; Carter, D; Mobasher, B

    2011-01-01

    We present a study of the fundamental plane, FP, for a sample of 71 dwarf galaxies in the core of Coma cluster in magnitude range $-21 < M_I <-15$. Taking advantage of high resolution DEIMOS spectrograph on Keck II for measuring the internal velocity dispersion of galaxies and high resolution imaging of HST/ACS, which allows an accurate surface brightness modeling, we extend the fundamental plane (FP) of galaxies to $\\sim$1 magnitude fainter luminosities than all the previous studies of the FP in Coma cluster. We find that, the scatter about the FP depends on the faint-end luminosity cutoff, such that the scatter increases for fainter galaxies. The residual from the FP correlates with the galaxy colour, with bluer galaxies showing larger residuals from FP. We find $M/L \\propto M^{-0.15\\pm0.22}$ in F814W-band indicating that in faint dwarf ellipticals, the $M/L$ ratio is insensitive to the mass. We find that less massive dwarf ellipticals are bluer than their brighter counterparts, possibly indicating on...

  16. The composition and size distribution of the dust in the coma of comet Hale-Bopp

    CERN Document Server

    Min, M; De Koter, A; Waters, L B F M; Dominik, C

    2005-01-01

    We discuss the composition and size distribution of the dust in the coma of comet Hale-Bopp. We do this by fitting simultaneously the infrared emission spectrum measured by the infrared space observatory (ISO) and the measured degree of linear polarization of scattered light at various phase angles and 12 different wavelengths. The effects of particle shape on the modeled optical properties of the dust grains are taken into account. We constrain our fit by forcing the abundances of the major rock forming chemical elements to be solar. The infrared spectrum at long wavelengths reveals that large grains are needed in order to fit the spectral slope. The size and shape distribution we employ allows us to estimate the sizes of the crystalline silicates. The ratios of the strength of various forsterite features show that the crystalline silicate grains in Hale-Bopp must be submicron sized. We exclude the presence of large crystalline silicate grains in the coma. Because of this lack of large crystalline grains com...

  17. Diabetic Coma

    Science.gov (United States)

    ... Sometimes, people with diabetes who also have an eating disorder choose not to use their insulin as directed ... 22, 2015 Original article: ... of Nondiscrimination Advertising Mayo Clinic is a not-for-profit organization ...

  18. Myxoedema coma

    DEFF Research Database (Denmark)

    Salomo, Louise Havkrog; Laursen, Adam Hoegsbro; Reiter, Nanna

    2014-01-01

    A 48-year-old man was admitted to department of emergency medicine at a tertiary referral hospital due to dizziness and fatigue. Clinical features on admission were non-pitting oedema, dry skin, very sparse hair, a hoarse voice, hypothermia (rectal temperature 28.7°C), macroglossia, sinus...

  19. Water and carbon dioxide investigation in the inner coma of 67P/Churyumov-Gerasimenko

    Science.gov (United States)

    Migliorini, Alessandra; Piccioni, Giuseppe; Capaccioni, Fabrizio; Filacchione, Gianrico; Bockelée-Morvan, Dominique; Erard, Stefan; Leyrat, Cedric; Combi, Michael; Fougere, Nicolas; De Sanctis, Maria Cristina

    2015-11-01

    The study of 67P/CG coma environment is one of the primary scientific goals of the VIRTIS experiment aboard ESA Rosetta mission.In the present work, results of 74 observations acquired by VIRTIS-M IR channel in the 1-5 μm spectral range from 8 to 14 April 2015 are discussed. In this time, 67P/CG was at heliocentric distance of 1.9 AU, and the coma activity was monitored for about 10 full comet rotations. This allows one to tentatively correlate gas distribution with active areas on the nucleus and to disentangle gas emissions from dust.Vibrational emission lines of H2O and CO2 at 2.67 and 4.27 μm, respectively, are identified by VIRTIS-M imaging channel and mapped from the surface up to about 10 km altitude with a spatial resolution of approximately 40 m/px.The maximum H2O emission is mainly concentrated above Aten-Babi and Seth-Hapi active regions, which are located on the neck connecting the two principal lobes. The CO2 column density is quite poor in the neck region, while diffuse emission is clear above the small and great lobe regions. These observations confirm the anti correlation between these two main species, as already noticed by Bockelée-Morvan et al. (2015) and Hässig et al. (2014). Column density of both species decreases with altitude with the CO2 distribution decreasing more rapidly than the H2O. The H2O/CO2 ratio, which increases with the altitude, varies from 18.7 close to the nucleus to 30.8 at 2-3 km above the nucleus. These values refer to the equatorial region, calculated considering all the longitudes. Gas emission is maximum in the afternoon quadrant, from 12 LST to 18 LST.VIRTIS-M has revealed with unprecedented spatial resolution the distribution of gaseous species around a cometary nucleus and correlated the emissions with surface-active areas, altitude above the nucleus and local time. Our study confirms the asymmetric distribution of carbon dioxide, which has a more uniform distribution above the comet's nucleus than water vapour

  20. A Suzaku Search for Non-thermal Emission at Hard X-ray Energies in the Coma Cluster

    CERN Document Server

    Wik, Daniel R; Finoguenov, Alexis; Matsushita, Kyoko; Nakazawa, Kazuhiro; Clarke, Tracy E

    2009-01-01

    The brightest cluster radio halo known resides in the Coma cluster of galaxies. The relativistic electrons producing this diffuse synchrotron emission should also produce inverse Compton emission that becomes competitive with thermal emission from the ICM at hard X-ray energies. Thus far, claimed detections of this emission in Coma are controversial (Fusco-Femiano et al. 2004; Rossetti & Molendi 2004). We present a Suzaku HXD-PIN observation of the Coma cluster in order to nail down its non-thermal hard X-ray content. The contribution of thermal emission to the HXD-PIN spectrum is constrained by simultaneously fitting thermal and non-thermal models to it and a spatially equivalent spectrum derived from an XMM-Newton mosaic of the Coma field (Schuecker et al. 2004). We fail to find statistically significant evidence for non-thermal emission in the spectra, which are better described by only a single or multi-temperature model for the ICM. Including systematic uncertainties, we derive a 90% upper limit on t...

  1. Mt. Wendelstein Imaging of the Post-Perihelion Dust Coma of 67P/Churyumov-Gerasimenko in 2015/2016

    CERN Document Server

    Boehnhardt, Hermann; Kluge, Matthias; Ries, Christoph; Schmidt, Michael; Hopp, Ulrich

    2016-01-01

    Comet 67P/Churyumov-Gerasimenko (67P) was imaged with the 2m telescope at Mt. Wendelstein Observatory in the Alps. Coma and tail monitoring was performed during 51 nights between 22 August 2015 and 9 May 2016. The images through r and i Sloan Digital Sky Survey (SDSS) filters show the dust distribution around the comet, while images in the SDSS g filter indicate also the presence of coma gas in early September 2015. The dust color of 67P implies intrinsic reddening of 9 %/100nm. After maximum shortly after perihelion passage the dust activity decreased with a heliocentric exponent of 4.1 to 4.2 from late September 2015 until May 2016. The opposition surge during early 2016 can be explained by a linear light scattering phase function (beta ~ 0.04) or an asteroid-like HG-type phase function (G ~ 0.15). The radial brightness profile indicates a 'quasi-steady-state' dust coma from late September to the end of 2015. Dust fragmentation during about a month after perihelion may be responsible for radial coma profile...

  2. Microswitch- and VOCA-Assisted Programs for Two Post-Coma Persons with Minimally Conscious State and Pervasive Motor Disabilities

    Science.gov (United States)

    Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Buonocunto, Francesca; Sacco, Valentina; Colonna, Fabio; Navarro, Jorge; Oliva, Doretta; Signorino, Mario; Megna, Gianfranco

    2009-01-01

    Intervention programs, based on learning principles and assistive technology, were assessed in two studies with two post-coma men with minimally conscious state and pervasive motor disabilities. Study I assessed a program that included (a) an optic microswitch, activated via double blinking, which allowed a man direct access to brief music…

  3. Fractional excretion of beta-2-microglobulin in the urine of patients with normal or reduced renal function and hepatic coma

    DEFF Research Database (Denmark)

    Hansen, P B; Dalhoff, K; Joffe, P

    1991-01-01

    The purpose of this prospective study was to evaluate beta-2-microglobulin (beta 2m) as a differential diagnostic indicator between hepatic nephropathy (HN) and acute tubulointerstitial nephropathy (ATIN) in patients with reduced renal function and hepatic coma, and to determine whether beta 2m...

  4. Impact of positive coupling of the eye's trefoil and coma in retinal image quality and visual acuity.

    Science.gov (United States)

    Villegas, Eloy A; Alcón, Encarna; Artal, Pablo

    2012-08-01

    When the eye's higher-order aberrations are measured and reported, as important as the magnitude of each individual term are the possible combinations between them, which may change the overall retinal image quality and therefore visual performance. We have evaluated the relationships among different aberration terms in the human eye-coma, trefoil, and spherical aberration-and their effects on both retinal image quality and visual acuity (VA). In a group of normal young subjects with normal to excellent vision, we measured the eye's aberrations and high contrast VA under natural conditions after carefully correcting defocus and astigmatism. Among the different combinations of aberration terms, we only found a significant negative correlation (r2=0.30) between the vertical coefficients of trefoil C(3,-3) and coma C(3,-1). This is a positive coupling that produces a better retinal image quality than any of the other possible combinations of these terms. However, this improvement in image quality is limited by the presence of other aberrations. Only in a few eyes that presented the larger values of coupled vertical trefoil and coma appeared a significant improvement of image quality. Although we did not find a clear correction between the coma-trefoil vertical coupling and VA, most eyes with large amounts of aberrations (RMS>0.4 μm) have these terms coupled, keeping decimal acuity around 1.2 or higher.

  5. A dozen new galaxies caught in the act: Gas stripping and extended emission line regions in the Coma cluster

    CERN Document Server

    Yagi, Masafumi; Komiyama, Yutaka; Kashikawa, Nobunari; Furusawa, Hisanori; Okamura, Sadanori; Graham, Alister W; Miller, Neal A; Carter, David; Mobasher, Bahram; Jogee, Shardha

    2010-01-01

    We present images of extended H-alpha clouds associated with 14 member galaxies in the Coma cluster obtained from deep narrow band imaging observations with Suprime-Cam at the Subaru Telescope. The parent galaxies of the extended H-alpha clouds are distributed farther than 0.2 Mpc from the peak of X-ray emission of the cluster. Most of the galaxies have colors bluer than g-r approx 0.5 and they account for 57% of the blue (g-r<0.5) bright (r<17.8 mag) galaxies in the central region of the Coma cluster. They reside near the red- and blue-shifted edges of the Coma cluster's radial velocity distribution. These findings suggest that the most of the parent galaxies were recently captured by the Coma cluster potential and are now infalling toward the cluster center with their disk gas being stripped off and producing the observed H-alpha clouds.

  6. Escala de coma de Glasgow pediátrica modificada para cães

    OpenAIRE

    M.B. Andrade; E.F. Cole; Evêncio Neto,J.; Silva,A.C.J.; G.A.S. Aleixo; A.L.T. Cunha

    2010-01-01

    Com o objetivo de modificar a escala de coma de Glasgow pediátrica para utilização na medicina veterinária, foram utilizados 30 cães adultos com alterações neurológicas passíveis de avaliação da consciência. A escala modificada para cães foi aplicada em três momentos com intervalos de 48 horas entre eles, resultando em 90 eventos diversos. A escala foi aplicada para avaliação da abertura ocular (AO), da melhor resposta associada à vocalização (MRV) e da melhor resposta motora (MRM). Com a aná...

  7. From Voids to Coma: the prevalence of pre-processing in the local Universe

    CERN Document Server

    Cybulski, Ryan; Fazio, Giovanni G; Gutermuth, Robert A

    2014-01-01

    We examine the effects of pre-processing across the Coma Supercluster, including 3505 galaxies over 500 sq deg, by quantifying the degree to which star-forming (SF) activity is quenched as a function of environment. We characterise environment using the complementary techniques of Voronoi Tessellation, to measure the density field, and the Minimal Spanning Tree, to define continuous structures, and so we measure SF activity as a function of local density and the type of environment (cluster, group, filament, and void), and quantify the degree to which environment contributes to quenching of SF activity. Our sample covers over two orders of magnitude in stellar mass (10^8.5 to 10^11 Msun), and consequently we trace the effects of environment on SF activity for dwarf and massive galaxies, distinguishing so-called "mass quenching" from "environment quenching". Environmentally-driven quenching of SF activity, measured relative to the void galaxies, occurs to progressively greater degrees in filaments, groups, and...

  8. The possible formation of a hydrogen coma around comets at large heliocentric distances.

    Science.gov (United States)

    Bar-Nun, A; Prialnik, D

    1988-01-01

    An observational test--the detection of a hydrogen coma around comets at large heliocentric distances--is proposed for determining whether comets were formed by the agglomeration of unaltered, ice-coated, interstellar grains. Laboratory experiments showed that amorphous water ice traps H2, D2, and Ne below 20 K and does not release them completely until the ice is heated to 150 K. Gas/ice ratios as high as 0.63 are obtainable. Thus, if the ice-coated interstellar grains were not heated above approximately 110 K, prior to their agglomeration into cometary nuclei, the inward propagating heat waves should release from the comets a continuous flux of molecular hydrogen. This flux would exceed that of water molecules at approximately 3 AU preperihelion and approximately 4 AU postperihelion.

  9. Subacute sclerosing panencephalitis presenting as schizophrenia with an alpha coma pattern in a child.

    Science.gov (United States)

    Kartal, Ayşe; Kurt, Ayşegül Neşe Çitak; Gürkaş, Esra; Aydin, Kurşad; Serdaroğlu, Ayşe

    2014-10-01

    Subacute sclerosing panencephalitis, a progressive neurodegenerative disorder of the central nervous system, can present atypically with uncharacteristic electroencephalographic (EEG) features at its onset albeit typically with progressive mental deterioration, behavioral changes, and myoclonic jerks. An atypical presentation of subacute sclerosing panencephalitis can lead to a delay in diagnosis, thus hindering early treatment. Herein, we describe a 14-year-old girl who presented with insomnia, amnesia, auditory and visual hallucinations. The patient's electroencephalography on admission showed an alpha coma pattern. In spite of antipsychiatric treatment (olanzapine 20 mg/d) for 3 months, a progressive deterioration in neurologic function was observed. Subacute sclerosing panencephalitis was suspected and diagnosis was confirmed by increased titers of measles antibodies in the cerebrospinal fluid. The attention of pediatricians should be drawn to psychiatric symptoms as possible initial presentations of subacute sclerosing panencephalitis in order to avoid needless diagnostic and treatment procedures.

  10. The Mass Of The Coma Cluster From Weak Lensing In The Sloan Digital Sky Survey

    Energy Technology Data Exchange (ETDEWEB)

    Kubo, Jeffrey M.; Stebbins, Albert; Annis, James; Dell' Antonio, Ian P.; Lin, Huan; Khiabanian, Hossein; Frieman, Joshua A.

    2007-09-01

    We present a weak lensing analysis of the Coma Cluster using the Sloan Digital Sky Survey (SDSS) Data Release Five. Complete imaging of a {approx} 200 square degree region is used to measure the tangential shear of this cluster. The shear is fit to an NFW model and we find a virial radius of r{sub 200} = 1.99{sup +0.21}{sub -0.22}h{sup -1}Mpc which corresponds to a virial mass of M{sub 200} = 1.88{sup +0.65}{sub -0.56} x 10{sup 15}h{sup -1}M{circle_dot}. We additionally compare our weak lensing measurement to the virial mass derived using dynamical techniques, and find they are in agreement. This is the lowest redshift, largest angle weak lensing measurement of an individual cluster to date.

  11. Coma blisters after poisoning caused by central nervous system depressants: case report including histopathological findings.

    Science.gov (United States)

    Branco, Maira Migliari; Capitani, Eduardo Mello De; Cintra, Maria Letícia; Hyslop, Stephen; Carvalho, Adriana Camargo; Bucaretchi, Fabio

    2012-01-01

    Blister formation and eccrine sweat gland necrosis is a cutaneous manifestation associated with states of impaired consciousness, most frequently reported after overdoses of central nervous system depressants, particularly phenobarbital. The case of a 45-year-old woman who developed "coma blisters" at six distinct anatomic sites after confirmed (laboratory) phenobarbital poisoning, associated with other central nervous system depressants (clonazepam, promethazine, oxcarbazepine and quetiapine), is presented. A biopsy from the left thumb blister taken on day 4 revealed focal necrosis of the epidermis and necrosis of sweat gland epithelial cells; direct immunofluorescence was strongly positive for IgG in superficial blood vessel walls but negative for IgM, IgA, C3 and C1q. The patient was discharged on day 21 with no sequelae.

  12. Self-induced drug intoxication in baclofen: of the calm hypotonic coma in the status epilepticus.

    Science.gov (United States)

    Thill, Chloé; Di Constanzo, Laurence; Pessey, François; Aries, Philippe; Montelescaut, Étienne; Sapin, Jeanne; Vaillant, Catherine; Drouillard, Isabelle

    2016-06-01

    Baclofen is an agonist of peripheral and central B gamma-aminobutyric acid receptors, whose activation causes a myorelaxation and a powerfull depression of the central nervous system. Moreover, it has an action against addiction, in reducing craving. Commercialized since 1975 in France, to control muscle spasticity due to medullar affection or multiple sclerosis, it receives a temporary recommendation of use in march 2014, as a last-line adjuvant treatment in alcohol withdrawal. Beyond its therapeutic use, baclofen is involved in many self-induced intoxications. We report the case of a patient who develops, after a massive ingestion of baclofen (supposed dose ingested: 1 200 mg), a hypotonic and calm coma, requiring her admission in our intensive care unit, and then a status epilepticus.

  13. Neutral Hydrogen and Star Formation in the Coma-Abell1367 Supercluster

    CERN Document Server

    Cortese, Luca

    2008-01-01

    We present preliminary results of a multi-wavelength study focused on the evolution of spiral galaxies in the UV-optical colour-magnitude (CM) diagram. By combining HI, UV and optical observations of the Coma-Abell1367 supercluster we are able to identify galaxies at different stages of their evolution: from healthy star-forming galaxies, to blue HI-poor spirals and transition objects. Our analysis shows that galaxies in the transition region are likely to be the progeny of healthy spirals, whose star-formation has been quenched by the harsh cluster environment. This result suggests that, at least in clusters of galaxies, the migration of galaxies from the blue to the red sequence might be due to environmental processes.

  14. Aspherical rotating dust dynamics for GIADA experiment in the coma of 67P/Churyumov- Gerasimenko

    Science.gov (United States)

    Ivanovski, S.; Zakharov, V.; Della Corte, V.; Lucarelli, F.; Crifo, J.-F.; Rotundi, A.; Fulle, M.

    2014-04-01

    The recent advances of the 3D+t cometary aspherical dust model [1, 2] have been used for studying the dust dynamics in the circumnuclear coma of the comet 67P/Churyumov-Gerasimenko (67P/C-G). This model will be used for analysis of the forthcoming in-situ dust data collected by GIADA (Grain Impact Analyzer and Dust Accumulator) [3] on board of the ESA ROSETTA probe. In the present research we study dust grain motion driven by the aerodynamic and gravitational forces and discuss the influence of dust grain's shape. We show the differences in dust grain velocities owing to the grain shape, initial orientation and rotation. The outcomes of the model are used to forecast by means of GIPSI [4] the dust distribution seen by GIADA at some of the ROSETTA operational phases.

  15. Etiologia e a morbi-letalidade do coma agudo em crianças

    Directory of Open Access Journals (Sweden)

    Löhr Junior Alfredo

    2003-01-01

    Full Text Available OBJETIVO: Analisou-se a etiologia e a morbi-mortalidade de 104 crianças em coma agudo, ou seja, com uma pontuação menor ou igual a 8 da escala de Glasgow, internadas na Unidade de Terapia Intensiva do Hospital Infantil Pequeno Príncipe(UTI-HIPP no período entre março/98 e janeiro/2001. RESULTADOS: A idade variou de 2 meses a 13 anos, com média de 30,3 ± 27,4 meses e mediana de 20 meses, sendo 57 (54,8% do sexo masculino. O tempo de permanência hospitalar variou de 1 a 114 dias, e 3 casos permaneceram em estado vegetativo persistente. Com relação à etiologia: 31 (29,8% dos casos foram devidos a meningoencefalite, 24 (23,1% estado de mal epiléptico, 19 (18,3% causa tóxico-metabólica, 16 (15,4% hipertensão intracraniana, 7 (6,7% choque/anóxia, 4 (3,8% etiologia indeterminada, 3 (2,9% miscelânea. Com relação à evolução das crianças, 23 (22,1% foram a óbito, 32 (30,8% evoluíram sem seqüelas, 39 (37,5% tiveram alta com seqüelas neurológicas e10 (9,6% não informado. CONCLUSÃO: De acordo com a análise do presente estudo conclui-se que cerca de um terço dos pacientes em coma agudo falece, um terço apresenta seqüelas neurológicas na alta hospitalar e um terço evoluim sem seqüelas.

  16. Coma dust environment observed by GIADA during the Perihelion of 67P/Churyumov-Gerasimenko.

    Science.gov (United States)

    Rotundi, A.; Della Corte, V.; Fulle, M.; Ferrari, M.; Ivanovski, S. L.; Sordini, R.; Mazzotta Epifani, E.; Palumbo, P.; Colangeli, L.; Lopez-Moreno, J. J.; Rodriguez, J.; Zakharov, V.; Bussoletti, E.; Crifo, J. F.; Esposito, F.; Green, S.; Gruen, E.; Lamy, P. L.; McDonnell, T.; Mennella, V.; Molina, A.; Moreno, F.; Ortiz, J. L.; Palomba, E.; Perrin, J. M.; Rodrigo, R.; Weissman, P. R.; Zarnecki, J.; Cosi, M.; Giovane, F.; Gustafson, B.; Herranz, M.; Jeronimo, J. M.; Leese, M.; Lopez-Jimenez, A.; Morales, R.

    2015-12-01

    GIADA (Grain Impact Analyzer and Dust Accumulator) is an in-situ instrument mounted onboard Rosetta monitoring the dust environment of comet 67P/Churyumov-Gerasimenko. GIADA is composed of 3 sub-systems: 1) the Grain Detection System, based on particle detection through light scattering; 2) the Impact Sensor, giving momentum measurement; 3) the Micro-Balances System, constituted of 5 quartz crystal microbalances, giving cumulative deposited dust. The combination of the measurements performed by these 3 subsystems provides: the number, the mass, the momentum and the speed distribution of dust particles emitted from the comet nucleus. We will present the coma dust environment as observed by GIADA during the perihelion phase of the Rosetta space mission. Despite the large distance from the nucleus, more than 200 km, GIADA was able to detect temporal and spatial variation of dust density distribution. Specific high dust spatial density sectors of the coma have been identified and their evolution during the perihelion phase was studied. Acknowledgements. GIADA was built by a consortium led by the Univ. Napoli "Parthenope" & INAF- Oss. Astr. Capodimonte, IT, in collaboration with the Inst. de Astrofisica de Andalucia, ES, Selex-ES s.p.a. and SENER. GIADA is presently managed & operated by Ist. di Astrofisica e Planetologia Spaziali-INAF, IT. GIADA was funded and managed by the Agenzia Spaziale Italiana, IT, with a support of the Spanish Ministry of Education and Science MEC, ES. GIADA was developped from a PI proposal supported by the University of Kent; sci. & tech. contribution given by CISAS, IT, Lab. d'Astr. Spat., FR, and Institutions from UK, IT, FR, DE and USA. We thank the RSGS/ESAC, RMOC/ESOC & Rosetta Project/ESTEC for their outstanding work. Science support provided by NASA through the US Rosetta Project managed by JPL/California Institute of Technology. GIADA calibrated data will be available through the ESA's PSA web site.

  17. Approximately a Thousand Ultra-diffuse Galaxies in the Coma Cluster

    Science.gov (United States)

    Koda, Jin; Yagi, Masafumi; Yamanoi, Hitomi; Komiyama, Yutaka

    2015-07-01

    We report the discovery of 854 ultra-diffuse galaxies (UDGs) in the Coma cluster using deep R band images, with partial B, i, and Hα band coverage, obtained with the Subaru telescope. Many of them (332) are Milky Way (MW) sized with very large effective radii of {r}{e}\\gt 1.5 {kpc}. This study was motivated by the recent discovery of 47 UDGs by Dokkum et al.; our discovery suggests \\gt 1000 UDGs after accounting for the smaller Subaru field (4.1 {{degree}}2; about one-half of Dragonfly). The new Subaru UDGs show a distribution concentrated around the cluster center, strongly suggesting that the great majority are (likely longtime) cluster members. They are a passively evolving population, lying along the red sequence in the color-magnitude diagram with no signature of Hα emission. Star formation was, therefore, quenched in the past. They have exponential light profiles, effective radii {r}{e}˜ 800\\{pc}-5 {kpc}, effective surface brightnesses {μ }{e}({\\text{}}R) = 25-28 mag arcsec-2, and stellar masses ˜ 1× {10}7{\\text{}}{M}⊙ -5× {10}8{\\text{}}{M}⊙ . There is also a population of nucleated UDGs. Some MW-sized UDGs appear closer to the cluster center than previously reported; their survival in the strong tidal field, despite their large sizes, possibly indicates a large dark matter fraction protecting the diffuse stellar component. The indicated baryon fraction ≲ 1% is less than the cosmic average, and thus the gas must have been removed (from the possibly massive dark halo). The UDG population is elevated in the Coma cluster compared to the field, indicating that the gas removal mechanism is related primarily to the cluster environment.

  18. A pediatric FOUR score coma scale: interrater reliability and predictive validity.

    Science.gov (United States)

    Czaikowski, Brianna L; Liang, Hong; Stewart, C Todd

    2014-04-01

    The Full Outline of UnResponsiveness (FOUR) Score is a coma scale that consists of four components (eye and motor response, brainstem reflexes, and respiration). It was originally validated among the adult population and recently in a pediatric population. To enhance clinical assessment of pediatric intensive care unit patients, including those intubated and/or sedated, at our children's hospital, we modified the FOUR Score Scale for this population. This modified scale would provide many of the same advantages as the original, such as interrater reliability, simplicity, and elimination of the verbal component that is not compatible with the Glasgow Coma Scale (GCS), creating a more valuable neurological assessment tool for the nursing community. Our goal was to potentially provide greater information than the formally used GCS when assessing critically ill, neurologically impaired patients, including those sedated and/or intubated. Experienced pediatric intensive care unit nurses were trained as "expert raters." Two different nurses assessed each subject using the Pediatric FOUR Score Scale (PFSS), GCS, and Richmond Agitation Sedation Scale at three different time points. Data were compared with the Pediatric Cerebral Performance Category (PCPC) assessed by another nurse. Our hypothesis was that the PFSS and PCPC should highly correlate and the GCS and PCPC should correlate lower. Study results show that the PFSS is excellent for interrater reliability for trained nurse-rater pairs and prediction of poor outcome and in-hospital mortality, under various situations, but there were no statistically significant differences between the PFSS and the GCS. However, the PFSS does have the potential to provide greater neurological assessment in the intubated and/or sedated patient based on the outcomes of our study.

  19. MAPPING THE GAS TURBULENCE IN THE COMA CLUSTER: PREDICTIONS FOR ASTRO-H

    Energy Technology Data Exchange (ETDEWEB)

    ZuHone, J. A. [Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Markevitch, M. [Astrophysics Science Division, X-ray Astrophysics Laboratory, Code 662, NASA/Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Zhuravleva, I. [Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, 452 Lomita Mall, Stanford, California 94305-4085 (United States)

    2016-02-01

    Astro-H will be able for the first time to map gas velocities and detect turbulence in galaxy clusters. One of the best targets for turbulence studies is the Coma cluster, due to its proximity, absence of a cool core, and lack of a central active galactic nucleus. To determine what constraints Astro-H will be able to place on the Coma velocity field, we construct simulated maps of the projected gas velocity and compute the second-order structure function, an analog of the velocity power spectrum. We vary the injection scale, dissipation scale, slope, and normalization of the turbulent power spectrum, and apply measurement errors and finite sampling to the velocity field. We find that even with sparse coverage of the cluster, Astro-H will be able to measure the Mach number and the injection scale of the turbulent power spectrum—the quantities determining the energy flux down the turbulent cascade and the diffusion rate for everything that is advected by the gas (metals, cosmic rays, etc.). Astro-H will not be sensitive to the dissipation scale or the slope of the power spectrum in its inertial range, unless they are outside physically motivated intervals. We give the expected confidence intervals for the injection scale and the normalization of the power spectrum for a number of possible pointing configurations, combining the structure function and velocity dispersion data. Importantly, we also determine that measurement errors on the line shift will bias the velocity structure function upward, and show how to correct this bias.

  20. Coma, metabolic acidosis, and methemoglobinemia in a patient with acetaminophen toxicity.

    Science.gov (United States)

    Kanji, Hussein D; Mithani, Shazma; Boucher, Paul; Dias, Valerian C; Yarema, Mark C

    2013-01-01

    We present a case of early coma, metabolic acidosis and methemoglobinemia after substantial acetaminophen toxicity in the absence of hepatic failure. A 77-year-old female presented to the emergency department with a decreased level of consciousness. She was found unresponsive by a family member in her bed, and was reported to be acting normally when she was last seen eight hours earlier. Laboratory results on arrival were: pH 7.19, sodium 139 mmol/L, chloride 106 mmol/L, potassium 3.3 mmol/L, CO2 8 mmol/L, and an anion gap of 25. Both venous lactate (10.2 mmol/L) and methemoglobin (9.4 %) were elevated. The patient's acetaminophen concentration was markedly elevated at 7138 µmol/L (1078 µg/ml). Hepatic enzymes and coagulation tests were normal [alanine transaminase (ALT) 8 U/L, international normalized ratio (INR) 1.0]. Intravenous N-acetylcysteine (NAC) was initiated at a dose of 150 mg/kg over 15 minutes, followed by 50 mg/kg over the next four hours, followed by 100 mg/kg over the next 16 hours. Twenty-four hours after admission, the anion gap metabolic acidosis had resolved, and the methemoglobin was 2.1%. Aminotransferases peaked at 44 U/L and INR peaked at 1.9. A urine 5-oxoproline assay performed five days after admission was negative, suggesting no evidence of a 5-oxoprolinase deficiency. We describe the pathophysiology and discuss the literature on acetaminophen-induced coma and metabolic acidosis in the absence of hepatic injury; and propose mechanisms for associated methemoglobinemia. 

  1. Proton therapy

    Science.gov (United States)

    Proton beam therapy; Cancer - proton therapy; Radiation therapy - proton therapy; Prostate cancer - proton therapy ... that use x-rays to destroy cancer cells, proton therapy uses a beam of special particles called ...

  2. Utilização da Escala de Coma de Glasgow e Escala de Coma de Jouvet para avaliação do nível de consciência Utilization of the Glasgow Coma Scale and Jouvet Coma Scale to evaluate the level of consciousness

    Directory of Open Access Journals (Sweden)

    Elaine Cristina S. Muniz

    1997-08-01

    Full Text Available A Escala de Coma de Glasgow (ECGl e a Escala de Coma de Jouvet (ECJ, são duas escalas usadas na avaliação da consciência em nosso meio. A análise e o uso dessas duas escalas têm indicado que elas se complementam, sendo a ECGl mais sensível à mudanças nos rebaixamentos mais intensos da consciência e a ECJ nos estados mais próximos do normal. O presente estudo teve como objetivo comparar os resultados obtidos na avaliação do nível de consciência no uso dessas duas escalas. A comparação foi realizada num estudo prospectivo com 48 pacientes maiores de 18 anos internados em três unidades gerais de terapia intensiva de diferentes hospitais privados do Município de São Paulo. As avaliações foram realizadas pelos pesquisadores diariamente, sendo as duas escalas aplicadas seqüencialmente uma à outra no tempo de aproximadamente 5 minutos. Cada uma das escalas foi aplicada em 106 avaliações realizadas e os resultados mostraram uma diferença estatisticamente significativa entre a ECGl e a ECJ na indicação de alteração de nível de consciência. Em 37,74% das avaliações realizadas com a ECJ houve indicação de alteração do nível de consciência, enquanto que na ECGl a alteração era apontada em apenas 23,58% das avaliações. Outra observação importante no uso de ambas escalas, foi que em indivíduos com escores na ECGl entre 9 e 11, a indicação de alteração de nível de consciência foi mais acentuada pela ECGl e naquelas com escores na ECGl entre 12 e 15 a ECJ indicou mais acentuada alteração de nível de consciência. No uso da ECGl houve aplicação do não testável (NT em 20% das avaliações realizadas, não ocorrendo inviabilidade de aplicação de indicadores na ECJ. Entretanto, acredita-se que condições específicas do grupo estudado favoreceram esse resultado, assim como, características específicas de grupos de pacientes podem favorecer o uso de diferentes escalas para avaliação de nível de

  3. ED disposition of the Glasgow Coma Scale 13 to 15 traumatic brain injury patient: analysis of the Transforming Research and Clinical Knowledge in TBI study☆,☆☆

    Science.gov (United States)

    Adeoye, Opeolu; Lindsell, Christopher J.; Hart, Kimberly W.; Pancioli, Arthur; McMullan, Jason T.; Yue, John K.; Nishijima, Daniel K.; Gordon, Wayne A.; Valadka, Alex B.; Okonkwo, David O.; Lingsma, Hester F.; Maas, Andrew I.R.

    2014-01-01

    Objective Mild traumatic brain injury (mTBI) patients are frequently admitted to high levels of care despite limited evidence suggesting benefit. Such decisions may contribute to the significant cost of caring for mTBI patients. Understanding the factors that drive disposition decision making and how disposition is associated with outcomes is necessary for developing an evidence-base supporting disposition decisions. We evaluated factors associated with emergency department triage of mTBI patients to 1 of 3 levels of care: home, inpatient floor, or intensive care unit (ICU). Methods This multicenter, prospective, cohort study included patients with isolated head trauma, a cranial computed tomography as part of routine care, and a Glasgow Coma Scale (GCS) score of 13 to 15. Data analysis was performed using multinomial logistic regression. Results Of the 304 patients included, 167 (55%) were discharged home, 76 (25%) were admitted to the inpatient floor, and 61 (20%) were admitted to the ICU. In the multivariable model, admission to the ICU, compared with floor admission, varied by study site, odds ratio (OR) 0.18 (95% confidence interval [CI], 0.06–0.57); antiplatelet/anticoagulation therapy, OR 7.46 (95% CI, 1.79–31.13); skull fracture, OR 7.60 (95% CI, 2.44–23.73); and lower GCS, OR 2.36 (95% CI, 1.05–5.30). No difference in outcome was observed between the 3 levels of care. Conclusion Clinical characteristics and local practice patterns contribute to mTBI disposition decisions. Level of care was not associated with outcomes. Intracranial hemorrhage, GCS 13 to 14, skull fracture, and current antiplatelet/anticoagulant therapy influenced disposition decisions. PMID:24857248

  4. Coma, cuidados de enfermería. Revisión bibliográfica sistemática

    OpenAIRE

    García Hernández, Lucas

    2016-01-01

    El coma es una urgencia médica que cursa con la ausencia de respuesta ante cualquier estímulo, es decir, la pérdida del nivel de conciencia. Su pronóstico dependerá de una rápida y correcta evaluación clínica. Su etiología puede ser estructural y/o tóxico-metabólica. Realizar una correcta anamnesis sobre el inicio del coma y una buena historia clínica facilitará el diagnóstico y el tratamiento del paciente. El objetivo de este trabajo es conocer cuál es la función de enfermería ante un pac...

  5. A Cluster Of Activities On Coma From The Hubble Space Telescope, StarDate, And McDonald Observatory

    Science.gov (United States)

    Hemenway, Mary Kay; Jogee, S.; Fricke, K.; Preston, S.

    2011-01-01

    With a goal of providing a vast audience of students, teachers, the general public, and Spanish-speakers with activities to learn about research on the Coma cluster of galaxies based on the HST ACS Treasury survey of Coma, McDonald Observatory used a many-faceted approach. Since this research offered an unprecedented legacy dataset, part of the challenge was to convey the importance of this project to a diverse audience. The methodology was to create different products for different (overlapping) audiences. Five radio programs were produced in English and Spanish for distribution on over 500 radio stations in the US and Mexico with a listening audience of over 2 million; in addition to the radio listeners, there were over 13,000 downloads of the English scripts and almost 6000 of the Spanish. Images were prepared for use in the StarDate Online Astronomy Picture of the Week, for ViewSpace (used in museums), and for the StarDate/Universo Teacher Guide. A high-school level activity on the Coma Cluster was prepared and distributed both on-line and in an upgraded printed version of the StarDate/Universo Teacher Guide. This guide has been distributed to over 1700 teachers nationally. A YouTube video about careers and research in astronomy using the Coma cluster as an example was produced. Just as the activities were varied, so were the evaluation methods. This material is based upon work supported by the National Aeronautics and Space Administration under Grant/Contract/Agreement No. HST-EO-10861.35-A issued through the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555.

  6. Non-ketotic hyperosmolar diabetic pre-coma due to pancreatitis in a boy on continuous ambulatory peritoneal dialysis.

    Science.gov (United States)

    Emder, P J; Howard, N J; Rosenberg, A R

    1986-01-01

    An unusual case of diabetes secondary to acute pancreatitis in a boy with end-stage renal failure receiving continuous ambulatory peritoneal dialysis (CAPD) is described. A hyperglycaemic, hyperosmolar pre-coma developed, aggravated by associated hypercalcaemia. The glucose content of the dialysis fluid contributed to the hyperglycaemia, which settled as the pancreatitis resolved and lower glucose concentration dialysis fluid was used. Our experience suggests that pancreatic dysfunction should be considered where significant hyperglycaemia occurs during peritoneal dialysis.

  7. Dust grains in the coma of 67P/Churyumov-Gerasimenko – link with surface properties and cometary activity

    Science.gov (United States)

    Capria, Maria Teresa; Ivanovski, Stavro; Zakharov, Vladimir; Capaccioni, Fabrizio; Filacchione, Gianrico; De Sanctis, Maria Cristina; rotundi, alessandra; della corte, vincenzo; Longobardo, Andrea; Palomba, Ernesto; colangeli, luigi; Bockelee-Morvan, Dominique; Érard, Stéphane; Leyrat, Cedric; VIRTIS, GIADA

    2016-10-01

    The imaging spectrometer VIRTIS and the dust analyzer GIADA, onboard Rosetta, made an extensive observation of the dust particles in the coma of the comet 67P/Churyumov-Gerasimenko. From the analysis of GIADA data, two different kind of particles have been revealed, compact and fluffy with different compositions and dynamical properties. Compact particles are characterized by densities of about 103 kg/m3, while fluffy particles have an almost fractal nature, with densities less than 1 kg/m3.In this work we present the initial results of a model linking the dust flux distribution, as obtained from a theoretical thermal nucleus model, with a model describing the dynamics of aspherical grains in the coma. The results are discussed in the context of the latest observations from VIRTIS and GIADA instruments.The 2D nucleus thermal model, when applied to the real shape of the comet, provides the size distribution and physical properties of the emitted grains at different times and location on the surface. The thermal model can simulate grains of various size distribution, composition and physical properties. This information is used as an input for the dust dynamical model that follows the emitted particles in the coma. The main source of heating is the solar illumination. In the dust dynamical model, the grain trajectory of emitted particles remains in a plane perpendicular to the rotational axis and the direction of illumination is taken to be in the same plane (i.e. does not cause transversal forces). The dust particles are assumed to be isothermal convex bodies and temperature changes only induce modest changes in the aerodynamic force (twice higher temperature changes aerodynamic force less than ~30%). This study reviews the theoretical values at which temperature difference starts to play a role on the dynamics. We discuss to what extent the particle's temperature affects the terminal velocities of the dust grains in the 67P coma in dependence on their mass and

  8. An adaptive and generalizable closed-loop system for control of medically induced coma and other states of anesthesia

    Science.gov (United States)

    Yang, Yuxiao; Shanechi, Maryam M.

    2016-12-01

    Objective. Design of closed-loop anesthetic delivery (CLAD) systems is an important topic, particularly for medically induced coma, which needs to be maintained for long periods. Current CLADs for medically induced coma require a separate offline experiment for model parameter estimation, which causes interruption in treatment and is difficult to perform. Also, CLADs may exhibit bias due to inherent time-variation and non-stationarity, and may have large infusion rate variations at steady state. Finally, current CLADs lack theoretical performance guarantees. We develop the first adaptive CLAD for medically induced coma, which addresses these limitations. Further, we extend our adaptive system to be generalizable to other states of anesthesia. Approach. We designed general parametric pharmacodynamic, pharmacokinetic and neural observation models with associated guidelines, and derived a novel adaptive controller. We further penalized large steady-state drug infusion rate variations in the controller. We derived theoretical guarantees that the adaptive system has zero steady-state bias. Using simulations that resembled real time-varying and noisy environments, we tested the closed-loop system for control of two different anesthetic states, burst suppression in medically induced coma and unconsciousness in general anesthesia. Main results. In 1200 simulations, the adaptive system achieved precise control of both anesthetic states despite non-stationarity, time-variation, noise, and no initial parameter knowledge. In both cases, the adaptive system performed close to a baseline system that knew the parameters exactly. In contrast, a non-adaptive system resulted in large steady-state bias and error. The adaptive system also resulted in significantly smaller steady-state infusion rate variations compared to prior systems. Significance. These results have significant implications for clinically viable CLAD design for a wide range of anesthetic states, with potential cost

  9. 儿童昏迷210例原因分析%Causes analysis of 210 cases with pediatric coma

    Institute of Scientific and Technical Information of China (English)

    邸春阳; 张妮; 王爱华

    2015-01-01

    目的 研究儿童重症监护病房(PICU)昏迷患儿的病因分布,以指导临床治疗.方法 采用回顾分析方法对210例昏迷患儿的病因进行分析.结果 210例昏迷患儿中,内科疾病150例,占71.43%,外科疾病60例,占28.57%.感染引起者110例,占52.38%,颅脑外伤58例,占27.62%,其中车祸31例,占14.76%.结论 PICU收治的昏迷患儿中,以感染性疾病为主,但外伤,尤其是车祸外伤所致昏迷患儿有所增加.因昏迷就诊患儿,尽快明确病因,对正确治疗及改善预后有积极意义.%Objective To investigate the causes of coma children in Pediatric Intensive Care Unit (PICU).Methods The causes of 210 children with coma were retrospectively analyzed.Results Among 210 cases,150 cases attributed to medical disease (71.43 %),while 60 cases attributed to surgical disease (28.57 %).110 cases were caused by infection(52.38%),58 cases were caused by cranioeerebral trauma (27.62%),while 31 cases involved in traffic accident(14.76%).Conclusion The main cause of coma in PICU is infectious diseases,but traffic accident trauma coma has been increased.It is positive to correct treatment and improve prognosis to recognize the cause as soon as possible.

  10. Prediction of recovery from a post-traumatic coma state by diffusion-weighted imaging (DWI) in patients with diffuse axonal injury

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, W.B.; Liu, G.R.; Wu, R.H. [Shantou University Medical College, Department of Radiology, Second Hospital, Shantou, Guangdong (China); Li, L.P. [Shantou University Medical College, Injury Prevention Research Center, Shantou, Guangdong (China)

    2007-03-15

    To determine whether diffusion-weighted magnetic resonance (MR) imaging findings combined with initial clinical factors indicate the depth of shearing lesions in the brain structure and therefore relate to coma duration in diffuse axonal injury (DAI). A total of 74 adult patients (48 male and 26 female) with DAI were examined with conventional MR imaging and diffusion-weighted MR imaging between 2 hours and 20 days after injury. Apparent diffusion coefficient (ADC) maps were obtained and the mean ADC values of each region of interest (ROI) were measured using MRI console software. The involvement of the brainstem, deep gray matter, and corpus callosum was determined for each sequence separately as well as for the combination of all sequences. The correlations between MR imaging findings indicating the presence of apparent brain injury combined with initial clinical factors were determined. Clinical characteristics, such as initial score on the Glasgow coma scale (GCS), age and number of all lesions, and ADC scores were predictive of the duration of coma. It was possible to predict post-traumatic coma duration in DAI from cerebral MR imaging findings combined with clinical prognostic factors in the acute to subacute stage after head injury. Age, ADC scores, GCS score and number of lesions were highly significant in predicting coma duration. The technique presented here might provide a tool for in vivo detection of DAI to allow the prediction of the coma duration during the early stages in patients with traumatic brain injury. (orig.)

  11. The HST/ACS Coma Cluster Survey III. Structural Parameters of Galaxies using single-S\\'ersic Fits

    CERN Document Server

    Hoyos, Carlos; Kleijn, Gijs Verdoes; Carter, David; Balcells, Marc; Guzman, Rafael; Peletier, Reynier; Ferguson, Henry C; Goudfrooij, Paul; Graham, Alister W; Hammer, Derek; Karick, Arna M; Lucey, John R; Matkovic, Ana; Merritt, David; Mouhcine, Mustapha; Valentijn, Edwin

    2010-01-01

    We present a catalogue of structural parameters for 8814 galaxies in the 25 fields of the HST/ACS Coma Treasury Survey. Parameters from S\\'ersic fits to the two-dimensional surface brightness distributions are given for all galaxies from our published Coma photometric catalogue with mean effective surface brightness brighter than 26.0 mag/sq. arcsec and brighter than 24.5 mag (equivalent to absolute magnitude - 10.5), as given by the fits, all in F814W(AB). The sample comprises a mixture of Coma members and background objects; 424 galaxies have redshifts and of these 163 are confirmed members. The fits were carried out using both the Gim2D and Galfit codes. We provide the following parameters: Galaxy ID, RA, DEC, the total corrected automatic magnitude from the photometric catalogue, the total magnitude of the model (F814W_AB), the geometric mean effective radius Re, the mean surface brightness within the effective radius _e, the S\\'ersic index n, the ellipticity and the source position angle. The selection l...

  12. Restore McComas Meadows; Meadow Creek Watershed, 2005-2006 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    McRoberts, Heidi (Nez Perce Tribe, Department of Fisheries Resource Management, Lapwai, ID)

    2006-07-01

    The Nez Perce Tribe Department of Fisheries Resource Management, Watershed Division approaches watershed restoration with a ridge-top to ridge-top approach. Watershed restoration projects within the Meadow Creek watershed are coordinated and cost shared with the Nez Perce National Forest. The Nez Perce Tribe began watershed restoration projects within the Meadow Creek watershed of the South Fork Clearwater River in 1996. Progress has been made in restoring the watershed by excluding cattle from critical riparian areas through fencing, planting trees in riparian areas within the meadow and its tributaries, prioritizing culverts for replacement to accommodate fish passage, and decommissioning roads to reduce sediment input. During this contract period work was completed on two culvert replacement projects; Doe Creek and a tributary to Meadow Creek. Additionally construction was also completed for the ditch restoration project within McComas Meadows. Monitoring for project effectiveness and trends in watershed conditions was also completed. Road decommissioning monitoring, as well as stream temperature, sediment, and discharge were completed.

  13. Glasgow Coma Scale scores, early opioids, and 4-year psychological outcomes among combat amputees

    Directory of Open Access Journals (Sweden)

    Ted Melcer, PhD

    2014-09-01

    Full Text Available Morphine and fentanyl are frequently used for analgesia after trauma, but there is debate over the advantages and disadvantages of these opioids. Among combat amputees, intravenous (IV morphine (vs IV fentanyl after injury was associated with reduced likelihood of posttraumatic stress disorder (PTSD. The previous results were based on military health diagnoses over 2 yr postinjury. The present study followed psychological diagnoses of patients with amputation for 4 yr using military and Department of Veterans Affairs health data. In-­theater combat casualty records (n = 145 documented Glasgow Coma Scale (GCS scores and/or morphine, fentanyl, or no opioid treatment within hours of injury. We found that (1 GCS scores were not significantly associated with PTSD; (2 longitudinal modeling using four (yearly time points showed significantly reduced odds of PTSD for patients treated with morphine (vs fentanyl across years (adjusted odds ratio = 0.40; 95% confidence interval = 0.17–0.94; (3 reduced PTSD prevalence for morphine (vs IV fentanyl; morphine = 25%, fentanyl = 59%, p < 0.05 was significant, specifically among patients with traumatic brain injury during the first 2 yr postinjury; and (4 PTSD prevalence, but not other disorders (e.g., mood, increased between year 1 (PTSD = 18% and years 2 through 4 postinjury (PTSD range = 30%–32%.

  14. Radial gradients in initial mass function sensitive absorption features in the Coma brightest cluster galaxies

    CERN Document Server

    Zieleniewski, Simon; Thatte, Niranjan; Davies, Roger L; Vaughan, Sam P

    2016-01-01

    Using the Oxford Short Wavelength Integral Field specTrograph (SWIFT), we trace radial variations of initial mass function (IMF) sensitive absorption features of three galaxies in the Coma cluster. We obtain resolved spectroscopy of the central 5kpc for the two central brightest-cluster galaxies (BCGs) NGC4889, NGC4874, and the BCG in the south-west group NGC4839, as well as unresolved data for NGC4873 as a low-$\\sigma_*$ control. We present radial measurements of the IMF-sensitive features sodium NaI$_{\\rm{SDSS}}$, calcium triplet CaT and iron-hydride FeH0.99, along with the magnesium MgI0.88 and titanium oxide TiO0.89 features. We employ two separate methods for both telluric correction and sky-subtraction around the faint FeH feature to verify our analysis. Within NGC4889 we find strong gradients of NaI$_{\\rm{SDSS}}$ and CaT but a flat FeH profile, which from comparing to stellar population synthesis models, suggests an old, $\\alpha$-enhanced population with a Chabrier, or even bottom-light IMF. The age an...

  15. A Distribution of Large Particles in the Coma of Comet 103P/Hartley 2

    CERN Document Server

    Kelley, Michael S; Bodewits, Dennis; A'Hearn, Michael F; Lisse, Carey M; Kolokolova, Ludmilla; Kissel, Jochen; Hermalyn, Brendan; 10.1016/j.icarus.2012.09.037

    2013-01-01

    The coma of comet 103P/Hartley 2 has a significant population of large particles observed as point sources in images taken by the Deep Impact spacecraft. We measure their spatial and flux distributions, and attempt to constrain their composition. The flux distribution of these particles implies a very steep size distribution with power-law slopes ranging from -6.6 to -4.7. The radii of the particles extend up to 20 cm, and perhaps up to 2 m, but their exact sizes depend on their unknown light scattering properties. We consider two cases: bright icy material, and dark dusty material. The icy case better describes the particles if water sublimation from the particles causes a significant rocket force, which we propose as the best method to account for the observed spatial distribution. Solar radiation is a plausible alternative, but only if the particles are very low density aggregates. If we treat the particles as mini-nuclei, we estimate they account for <16-80% of the comet's total water production rate (...

  16. Diagnostic Signatures of Radio and HXR Emission on Particle Acceleration Processes in the Coma Cluster

    CERN Document Server

    Kuo, P H; Ip, W H; Kuo, Ping-Hung; Hwang, Chorng-Yuan; Ip, Wing-Huen

    2003-01-01

    We investigate theoretical models for the radio halo and hard X-ray (HXR) excess in the Coma galaxy cluster. Time-independent and time-dependent re-acceleration models for relativistic electrons have been carried out to study the formation of the radio halo and HXR excess. In these models, the relativistic electrons are injected by merger shocks and re-accelerated by ensuing violent turbulence. The effects of different Mach numbers of the merger shocks on the radio and HXR excess emission are also investigated. We adopt 6 $mu$G as the central magnetic field and reproduce the observed radio spectra via the synchrotron emission. We also obtain a central "plateau" in the radio spectral-index distribution, which have been observed in radio emission distribution. Our models can also produce the observed HXR excess emission via the inverse Compton scattering of the cosmic microwave background photons. We find that only the merger shocks with the Mach numbers around 1.6--2 can produce results in agreement with both ...

  17. 12CO(1-0) observations of NGC 4848 a Coma galaxy after stripping

    CERN Document Server

    Vollmer, B; Balkowski, C; Cayatte, V; Duschl, W J

    2001-01-01

    We study the molecular gas content and distribution in the Coma cluster spiral galaxy NGC 4848. Plateau de Bure interferometric CO(1-0) observations reveal a lopsided H_2 distribution with an off-center secondary maximum coincident with the inner part of the HI. NGC 4848 is not at all deficient in molecular gas as it contains M_H_2~4x10^9 M_solar. At the interface between the CO and HI emission regions, about 8 kpc NW of the center, however, strong star formation is present as witnessed by Halpha and radio continuum emission. This is the region in which earlier Fabry-Perot observations revealed a double-peaked Halpha line, indicating gas at two different velocities at the same sky position. In order to understand these observations, we present the results of numerical simulations of the ISM-ICM interaction. We suggest that NGC 4848 already passed through the center of the cluster about 4x10^8 years ago. At the observed stage ram pressure has no more direct dynamical influence on the galaxy's ISM. We observe t...

  18. Study of FK Comae Berenices: VII. Correlating photospheric and chromospheric activity

    CERN Document Server

    Vida, K; Ilyin, I V; Oláh, K; Andersen, M I; Hackman, T

    2015-01-01

    We study the connection between the chromospheric and photospheric behaviour of the active late-type star FK Comae. We use spot temperature modelling, light curve inversion based on narrow- and wide-band photometric measurements, Halpha observations from 1997-2010, and Doppler maps from 2004-2010 to compare the behaviour of chromospheric and photospheric features. Investigating low-resolution Halpha spectra we find that the changes in the chromosphere seem to happen mainly on a time scale longer than a few hours, but shorter variations were also observed. According to the Halpha measurements prominences are often found in the chromosphere that reach to more than a stellar radius and are stable for weeks, and which seem to be often, but not every time connected with dark photospheric spots. The rotational modulation of the Halpha emission seems to typically be anticorrelated with the light curve, but we did not find convincing evidence of a clear connection in the long-term trends of the Halpha emission and th...

  19. Ultraviolet tails and trails in cluster galaxies: A sample of candidate gaseous stripping events in Coma

    CERN Document Server

    Smith, Russell J; Hammer, Derek; Hornschemeier, Ann E; Carter, David; Hudson, Michael J; Marzke, Ronald O; Mouhcine, Mustapha; Eftekharzadeh, Sareh; James, Phil; Khosroshahi, Habib; Kourkchi, Ehsan; Karick, Arna

    2010-01-01

    We have used new deep observations of the Coma cluster from GALEX to identify 13 star-forming galaxies with asymmetric morphologies in the ultraviolet. Aided by optical broad-band and H-alpha imaging, we interpret the asymmetric features as being due to star formation within gas stripped from the galaxies by interaction with the cluster environment. The selected objects display a range of structures from broad fan-shaped systems of filaments and knots (`jellyfish') to narrower and smoother tails extending up to 100 kpc in length. Some of the features have been discussed previously in the literature, while others are newly identified here. As an ensemble, the candidate stripping events are located closer to the cluster centre than other star-forming galaxies; their radial distribution is similar to that of all cluster members, dominated by passive galaxies. The fraction of blue galaxies which are undergoing stripping falls from 40% in the central 500 kpc, to less than 5% beyond 1 Mpc. We find that tails pointi...

  20. Tetralogy Surgery - Back To Baltimore 70 Years Later: Melbourne Heritage and Group Tribute to Juan Comas.

    Science.gov (United States)

    Sarris, George E

    2017-01-01

    Surgery for Tetralogy of Fallot progressed rapidly from the palliative arterio-pulmonary Blalock-Taussig shunt, introduced in Baltimore 70 years ago, to the "classic" complete transventricular repair technique, with which excellent early results were achieved soon thereafter. However, as duration of follow-up increased, so did the awareness of development of troubling late complications, including severe pulmonary insufficiency, right ventricular dilatation and dysfunction, and tricuspid valve insufficiency, all contributing to increasing incidence of late reoperations, as well as to arrhythmias and sudden death. This realization fueled the initial introduction of the transatrial-transpulmonary repair technique by Kawashima, as well as the subsequent firm establishment of this technique within the framework of an integrated surgical approach by Roger Mee in Melbourne. In turn, Mee's numerous trainees and associates led the dissemination of this approach and provided the impetus for the current wide adoption of a variety of right ventricular and pulmonary valve preservation techniques. In addition to the outstanding surgical results reported by individual centers adopting this surgical strategy, encouraging multi-institutional data are emerging regarding the benefits of these approaches for more favorable early and, most importantly, late outcome. One student and strong proponent of the Melbourne approach was our late colleague and friend Juan Comas, to whose memory this article can serve as tribute.

  1. A rabbit model of fatal hypothyroidism mimicking "myxedema coma" established by microscopic total thyroidectomy.

    Science.gov (United States)

    Ono, Yosuke; Fujita, Masanori; Ono, Sachiko; Ogata, Sho; Tachibana, Shoichi; Tanaka, Yuji

    2016-06-30

    Myxedema coma (MC) is a life-threatening endocrine crisis caused by severe hypothyroidism. However, validated diagnostic criteria and treatment guidelines for MC have not been established owing to its rarity. Therefore, a valid animal model is required to investigate the pathologic and therapeutic aspects of MC. The aim of the present study was to establish an animal model of MC induced by total thyroidectomy. We utilized 14 male New Zealand White rabbits anesthetized via intramuscular ketamine and xylazine administration. A total of 7 rabbits were completely thyroidectomized under a surgical microscope (thyroidectomized group) and the remainder underwent sham operations (control group). The animals in both groups were monitored without thyroid hormone replacement for 15 weeks. Pulse rate, blood pressure, body temperature, and electrocardiograms (ECG) were recorded and blood samples were taken from the jugular vein immediately prior to the thyroidectomy and 2 and 4 weeks after surgery. The thyroidectomized rabbits showed a marked reduction of serum thyroxine levels at 4 weeks after the surgical procedure vs. controls (0.50±0.10 vs. 3.32±0.68 μg/dL, pcontrols. Of the 7 rabbits with severe hypothyroidism, 6 died from 4 to 14 weeks after the thyroidectomy possibly owing to heart failure, because histopathologic examinations revealed a myxedema heart. In summary, we have established a rabbit model of fatal hypothyroidism mimicking MC, which may facilitate pathophysiological and molecular investigations of MC and evaluations of new therapeutic interventions.

  2. VizieR Online Data Catalog: Sersic + exponential disc morphologies in Coma (Head+, 2015)

    Science.gov (United States)

    Head, J. T. C. G.; Lucey, J. R.; Hudson, M. J.

    2016-04-01

    This study makes use of the data as previously described in Paper I (Head et al., 2014, Cat. J/MNRAS/440/1690). To recap: optical imaging covering a total of 9 deg2 of the Coma Cluster in the i band was acquired using the MegaCam instrument on the 3.6 m CFHT during 2008 March-June (run ID 2008AC24, PI: M. Hudson). Total (co-added) exposure times of 300 s were obtained for each observed field, yielding ~12 x deeper imaging data (from D2texp) compared to SDSS (2.5m telescope, 53s exposures). The MegaCam frames were sky-subtracted during pre-processing using a 64 pixel mesh. A point spread function (psf) full width at half-maximum of between 0.65 and 0.84-arcsec was typical. The pixel scale was ~0.186arcsec/pix. In this work, we fit galaxies with a range of analytical models in order to thoroughly explore the diversity of internal galaxy structures. (1 data file).

  3. A massive white dwarf member of the Coma Berenices Open Cluster

    CERN Document Server

    Dobbie, P D; Burleigh, M R; Boyce, D D

    2009-01-01

    We report the identification, from a photometric, astrometric and spectroscopic study, of a massive white dwarf member of the nearby, approximately solar metalicity, Coma Berenices open star cluster (Melotte 111). We find the optical to near-IR energy distribution of WD1216+260 to be entirely consistent with that of an isolated DA and determine the effective temperature and surface gravity of this object to be $T_{\\rm eff}$=$15739^{+197}_{-196}$K and log $g$=$8.46^{+0.03}_{-0.02}$. We set tight limits on the mass of a putative cool companion, M$\\simgreat$0.036M$_{\\odot}$ (spatially unresolved) and M$\\simgreat$0.034M$_{\\odot}$, (spatially resolved and a$\\simless$2500AU). Based on the predictions of CO core, thick-H layer evolutionary models we determine the mass and cooling time of WD1216+260 to be M$_{\\rm WD}$=$0.90 \\pm0.04$M$_{\\odot}$ and $\\tau

  4. Giotto IMS measurements of the production rate of hydrogen cyanide in the coma of comet Halley

    Energy Technology Data Exchange (ETDEWEB)

    Ip, W.H.; Rosenbauer, H.; Schwenn, R. (Max-Planck-Institut fuer Aeronomie, Katlenburg-Lindau, (DE)); Balsiger, H.; Geiss, J.; Meier, A. (Bern Univ. (CH). Physikalisches Inst.); Goldstein, B.E. (California Inst. of Techn., Pasadena, CA (US)); Lazarus, A.J. (Massachusetts Inst. of Techn., Cambridge, MA (US). Center for Space Research); Shelley, E. (Lockheed Palo Alto Research Lab., CA (US)); Kettmann, G. (Los Alamos National Lab., NM (US))

    1990-05-01

    The ion composition measurements in the ionosphere of comet Halley by the ion mass spectrometer (IMS) experiment on the Giotto spacecraft are used to estimate the relative abundance of HCN. From a comparison of the normalized number density of ions with mass-to-charge (M/q) ratio of 28 AMU/e with steady-state photochemical models, it can be determined that the production rate of HCN directly from the central nucleus is Q(HCN) <{approx} 2 x 10{sup -4} Q(H{sub 2}O) at the time of Giotto encounter. The related photo chemical model calculations also indicate that Q(NH{sub 3})/Q(H{sub 2}O) {approx} 5 x 10{sup -3} in agreement with recent determination from ground-based observations. The estimated value of Q(HCN) is lower than the relative abundance of Q(HCN)/Q(H{sub 2}O) {approx} 10{sup -3} as derived from radio observations of the 88.6 GHz emission of the J = 1 - 0 transition of HCN. The difference may be the result of time-variations of the coma composition and dynamics as well as other model-dependent effects.

  5. Assessing consciousness in coma and related states using transcranial magnetic stimulation combined with electroencephalography.

    Science.gov (United States)

    Gosseries, O; Thibaut, A; Boly, M; Rosanova, M; Massimini, M; Laureys, S

    2014-02-01

    Thanks to advances in medical care, an increased number of patients recover from coma. However, some remain in vegetative/unresponsive wakefulness syndrome or in a minimally conscious state. Detection of awareness in severely brain-injured patients is challenging because it relies on behavioral assessments, which can be affected by motor, sensory and cognitive impairments of the patients. Other means of evaluation are needed to improve the accuracy of the diagnosis in this challenging population. We will here review the different altered states of consciousness occurring after severe brain damage, and explain the difficulties associated with behavioral assessment of consciousness. We will then describe a non-invasive technique, transcranial magnetic stimulation combined with high-density electroencephalography (TMS-EEG), which has allowed us to detect the presence or absence of consciousness in different physiological, pathological and pharmacological states. Some potential underlying mechanisms of the loss of consciousness will then be discussed. In conclusion, TMS-EEG is highly promising in identifying markers of consciousness at the individual level and might be of great value for clinicians in the assessment of consciousness.

  6. JKCS041: a Coma cluster progenitor at z=1.803

    CERN Document Server

    Andreon, S; Trinchieri, G; Raichoor, A; Ellis, R S; Treu, T

    2013-01-01

    Using deep two-color near-infrared HST imaging and unbiased grism spectroscopy we present a detailed study of the z=1.803 JKCS041 cluster. Uniquely, for a high redshift cluster, we confirm a mass of $\\log M=14.2$ in solar units using three different techniques based on the X-ray temperature, the X-ray luminosity and the cluster richness. JKCS041 is thus a progenitor of a local system like the Coma cluster. Our rich dataset and the abundant population of 14 spectroscopically-confirmed red sequence galaxies allows us to explore the past star formation history of this system in unprecedented detail. Remarkably, we find a prominent red sequence down to stellar masses as low as $\\log M=9.8$, corresponding to a mass range of 2 dex. These quiescent galaxies are concentrated around the cluster center with a core radius of 330 kpc. Blue members are few and avoid the cluster center. In JKCS041 quenching was therefore largely completed by a look-back time of 10 Gyr and we can constrain the epoch at which this occurred v...

  7. Suzaku Observations of Iron K-lines from the Intracluster Medium of the Coma Cluster

    CERN Document Server

    Sato, Takuya; Ota, Naomi; Sato, Kosuke; Nakazawa, Kazuhiro; Sarazin, Craig L

    2011-01-01

    The Coma cluster was observed with an X-ray Imaging Spectrometer (XIS) onboard Suzaku in six pointings, including the central X-ray peak region, the 14'west offset region, 30'and 34'north-west offset regions, and 44'and 60'south-west offset regions. Owing to its lower background level, Suzaku has better sensitivity to Fe K-alpha lines than other satellites. Using precise Fe line measurements, we studied the temperature structure, possible bulk motions, and iron abundance distributions in the intracluster medium (ICM). The observed spectra were well-represented by a single-temperature model, and two- or three- temperature model did not improve chi-square substantially. The temperature, derived from K-alpha line ratios of H-like and He-like Fe, agree with those derived from the single-temperature model. Because the line ratio is a steep function of temperature, the consistency supports the accuracy of temperature measurements conducted with Suzaku. Within the 34'region, the redshift derived from the central ene...

  8. Modified Glasgow Coma Scale to predict mortality in febrile unconscious children.

    Science.gov (United States)

    Chaturvedi, P; Kishore, M

    2001-04-01

    A prospective hospital based study was conducted in the Department of Pediatrics of the Kasturba Hospital, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha to predict the mortality in children admitted with fever and unconsciousness using the Modified Glasgow Coma Scale (MGCS) score. Forty eight children were admitted with fever and unconsciousness; cases of febrile convulsions, epilepsy and cerebral palsy were excluded. MGCS scores were assessed on admission and repeated at 12 hours, 24 hours, 48 hours and 72 hours after admission in each case. Diagnosis in each case was confirmed by history, examinations and investigations. All the cases were regularly followed up till death/discharge. The overall mortality was 29.1% (14/48) out of which 85% (12/14) died within the first 24 hours. Mortality was highest in the toddler age group and in patients with pyogenic meningitis. There was a significant association between death and MGCS scores on admission with a post test probability for discharge being only 10% with a score of less than 5 and 99% with a score of more than 10 respectively. MGCS scores on admission can be used to predict mortality in patients hospitalized with fever and unconsciousness. The scale is simple, easy, can be applied at bed side and does not need any investigations. Its application in developing countries with limited investigative and intensive care facilities can help the treating physician decide regarding referral and counseling the parents regarding the probable clinical outcome.

  9. Coma y acidosis metabólica: Intoxicación por metanol

    Directory of Open Access Journals (Sweden)

    J Villegas del Ojo

    2011-01-01

    Full Text Available La intoxicación por metanol es un proceso poco frecuente en la actualidad, a pesar de su uso habitual en la industria, laboratorios y hogar. La vía de intoxicación suele ser la oral y, dada su elevada mortalidad, debe considerarse siempre una intoxicación grave. Se presenta el caso clínico de un paciente joven extranjero sin antecedentes, en coma y con acidosis metabólica grave, que evoluciona a muerte encefálica a pesar de establecer medidas de soporte y tratamiento específico (corrección de acidosis, etanol, diálisis instaurado empíricamente a las 12 horas del ingreso, confirmándose posteriormente la intoxicación por metanol. En conclusión, debe destacarse la importancia del diagnostico precoz, dado el amplio periodo de latencia, la escasa sintomatología inicial y la alta mortalidad, sospechándose ante un paciente con acidosis metabólica con anión gap aumentado y alteraciones neurológicas, pues el diagnóstico de certeza es su presencia en plasma, técnica no disponible en la mayoría de los hospitales.

  10. Low CD4 count plus coma predicts cryptococcal meningitis in Tanzania

    Directory of Open Access Journals (Sweden)

    Mueller Andreas

    2007-05-01

    Full Text Available Abstract Background Largely due to the lack of diagnostic reagents, the prevalence and clinical presentation of cryptococcal meningitis in Tanzania is poorly understood. This in turn is limiting the impact of increased fluconazole availability. Methods We evaluated a cohort of 149 consecutive HIV-infected adult inpatients presenting with headache or altered mental status for clinical features, CD4 count, cryptococcal infection, and outcome. Cryptococcal meningitis was diagnosed via India ink and latex agglutination assay of CSF (n = 24 and 40 positive, respectively. Associations between cryptococcal meningitis and clinical features were evaluated by t-test. The sensitivity, specificity, and positive likelihood ratio of such features were determined. Results Cryptococcal meningitis was associated with confusion, social withdrawal, seizures, fever, tachycardia, meningismus, oral candidiasis, and low Glasgow coma scales and CD4 count. CD4 count Conclusion Cryptococcal meningitis is common among Tanzanian HIV inpatients presenting with headache or altered mental status. Purely clinical features are insensitive for establishing the diagnosis or prognosis. We advocate expanding laboratory capacity for cryptococcal antigen testing to maximize survival.

  11. Galveston Orientation and Amnesia Test: applicability and relation with the Glasgow Coma Scale Galveston Orientation and Amnesia Test: aplicabilidad y relación con la Escala de Coma de Glasgow Galveston Orientation and Amnesia Test: aplicabilidade e relação com a Escala de Coma de Glasgow

    OpenAIRE

    Silvia Cristina Fürbringer e Silva; Regina Marcia Cardoso de Sousa

    2007-01-01

    Restrictions in the application of the Galveston Orientation and Amnesia Test and questionings about the relationship between conscience and post-traumatic amnesia motivated this study, which aims to identify, through the Glasgow Coma Scale scores, when to initiate the application of this amnesia test, as well to verify the relationship between the results of these two indicators. The longitudinal prospective study was carried at a referral center for trauma care in São Paulo - Brazil. The sa...

  12. Potencial evocado auditivo de tronco encefálico no prognóstico do coma superficial

    Directory of Open Access Journals (Sweden)

    Libia Camargo Ribeiro Leite

    2013-08-01

    Full Text Available O coma é a redução persistente do nível de consciência, arresponsivo a estímulos, devido à baixa atividade cerebral. Para verificar o nível de consciência, um recurso frequentemente utilizado é a Escala de Coma de Glasgow. Outro método que se destaca é o Potencial Evocado Auditivo de Tronco Encefálico, o qual avalia a atividade elétrica das vias auditivas ascendentes, desde o trajeto periférico até o mesencéfalo. O exame é simples, imune a medicamentos depressores e ambientes eletricamente carregados, sendo o mais adequado dos potenciais para a monitoração dos estados de coma. O presente estudo teve por objetivo verificar as características do Potencial Evocado Auditivo de Tronco Encefálico no estado de coma leve (Glasgow 7 - 8 e suas respectivas contribuições. Foi realizado um estudo prospectivo transversal em dois pacientes em coma (Glasgow 7, estado secundário a traumatismo cranioencefálico. Os resultados do exame evidenciaram presença de atividade elétrica em toda extensão da via estudada, em ambos os casos, com indicações de diferentes alterações, quanto à redução na latência entre os intervalos, morfologia e replicação das ondas. Tais diferenças foram contempladas com a evolução de cada caso: caso 1 evoluiu a alta hospitalar e caso 2 evoluiu a óbito. Os resultados confirmaram os achados da literatura, que descreve que a presença do Potencial Evocado Auditivo de Tronco Encefálico normal está associada à boa evolução do caso clínico, enquanto alterações no exame podem sinalizar para um mau prognóstico.

  13. Primate study suggests pentobarbital may help protect the brain during radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Skolnick, A.

    1990-08-01

    Radiation therapy, an often indispensable treatment for a wide range of brain tumors, is a double-edged sword, especially when used to treat children. Research reported at the 72nd Annual Meeting of the Endocrine Society, in Atlanta, Ga., now suggests that pentobarbital and perhaps other barbiturates may help protect the brain from radiation-induced damage, especially to the pituitary and hypothalmus, where such damage can lead to serious, life-long problems for children. Jeffrey J. Olson, MD, now assistant professor of neurosurgery at Emory University School of Medicine, Atlanta, reported the results of a study of the radioprotective effects of pentobarbital on the brain of a primate, which he and colleagues at the National Institute of Neurological Disorders and Stroke recently completed.

  14. [Hypernatremia - Diagnostics and therapy].

    Science.gov (United States)

    Arndt, Christian; Wulf, Hinnerk

    2016-05-01

    Hypernatremia is a common electrolyte disorder that reflects an imbalance in the water balance of the body, often resulting from an increased loss of free water compared to sodium excretion. It is rarely based on excessive sodium intake. The clinical presentation is often characterized by a central nervous system dysfunction (confusion, coma) and pronounced thirst (in awake patients). In addition to medical history, the volume status of the patient and the osmolality of urine are leading in the differential diagnosis. Usually, the treatment of hypernatremia - in addition to addressing the underlying cause - is replacing the (absolute or relative) loss of free water by hypotonic infusions, or in case of diabetes insipidus, by application of Desmopressin (Minirin). As rapid changes in serum sodium concentration may have deleterious consequences (osmotic demyelinsiation syndrome), preexisting hypernatremia (>48h) should not be reduced by more than 8-10 mmol/l/day. Close laboratory controls are important. For acute hypernatremia (< 24 hours), hemodialysis is an effective option to rapidly normalize the serum sodium levels. To avoid a rapid drop in sodium concentration that must also be considered when starting a renal replacement therapy in patients with chronic hypernatremia.

  15. Análise Temporal da Coma de CO+ no Cometa P/Halley

    Science.gov (United States)

    Voelzke, M. R.; Schlosser, W.; Schmidt-Kaler, Th.

    1995-08-01

    Observações fotográficas e fotoelétricas da coma de gás ionizado do cometa P/Halley a nível de CO+ em 4250 angstroms fizeram parte do programa de Monitoramento do Halley desenvolvido pela Universidade de Bochum (Ruhr-Universitaet Bochum) na Alemanha, realizado de 17 de fevereiro a 17 de abril de 1986 no European Southern Observatory (ESO) em La Silla (Chile). Nesta faixa espectral é possível observar a contínua formação, bem como o movimento e expansão das estruturas de plasma. Para observar a morfologia destas estruturas foram analisadas 32 placas fotográficas de CO+ (placas de vidro) do cometa P/Halley. Tais placas possuem um campo de visão de 28,6 por 28,6 graus sendo obtidas entre 29 de março e 17 de abril de 1986 com tempos de exposição entre 20 e 120 minutos. Todas as placas foram digitadas com o auxílio de um microdensitômetro PDS 2020 GM (Photometric Data System) do Instituto Astronómico da Westfaelischen Wilhelms-Universitaet em Muenster, Alemanha (um pixel = 25 por 25 micrômetros correspondendo aproximadamente a 46,88 por 46,88 segundos de arco). Após a digitação os dados foram reduzidos à intensidades relativas, sendo que os posssíveis de calibração também foram reduzidos à intensidades absolutas, expressas em termos de densidade colunar utilizando-se dos sistemas de tratamento de imagens MIDAS (Munich Image Data Analysis System; ESO - Image Processing Group, 1988) e IHAP (Image Handling And Processing; Middleburg, 1983). Com o auxílio do método de teta mínimo de Stellingwerf (Stellingwerf, 1978) obteve-se um período de 2,22 +/- 0,09 dias a partir da análise de estruturas na coma de plasma através da subtração de imagens subsequentes. Este método foi comparado com o método de Fourier. Provavelmente exista um segundo ciclo com período aproximado de 3,6 dias. A idéia de subtrair imagens subsequentes é devido ao fato de que os efeitos de rotação são apenas 10% dos fenômenos de distribuição gasosa. Portanto as

  16. FK Comae Berenices, King of Spin: The COCOA-PUFS Project

    Science.gov (United States)

    Ayres, Thomas R.; Kashyap, V.; Saar, S.; Huenemoerder, D.; Korhonen, H.; Drake, J. J.; Testa, P.; Cohen, O.; Garraffo, C.; Granzer, T.; Strassmeier, K.

    2016-03-01

    COCOA-PUFS is an energy-diverse, time-domain study of the ultra-fast spinning, heavily spotted, yellow giant FK Comae Berenices (FK Com: HD117555; G4 III). This single star is thought to be a recent binary merger, and is exceptionally active by measure of its intense ultraviolet (UV) and X-ray emissions, and proclivity to flare. COCOA-PUFS was carried out with the Hubble Space Telescope in the UV (1200-3000 Å), using mainly its high-performance Cosmic Origins Spectrograph, but also high precision Space Telescope Imaging Spectrograph; Chandra X-ray Observatory in the soft X-rays (0.5-10 keV), utilizing its High-Energy Transmission Grating Spectrometer; together with supporting photometry and spectropolarimetry in the visible from the ground. This is an introductory report on the project. FK Com displayed variability on a wide range of timescales over all wavelengths during the week-long main campaign, including a large X-ray flare; “super-rotational broadening” of the far-ultraviolet “hot lines” (e.g., Si iv 1393 Å 8 × 104 K) together with chromospheric Mg ii 2800 Å and C ii 1335 Å (1-3 × 104 K); large Doppler swings suggestive of bright regions alternately on advancing and retreating limbs of the star; and substantial redshifts of the epoch-average emission profiles. These behaviors paint a picture of a highly extended, dynamic, hot (˜10 MK) coronal magnetosphere around the star, threaded by cooler structures perhaps analogous to solar prominences and replenished continually by surface activity and flares. Suppression of angular momentum loss by the confining magnetosphere could temporarily postpone the inevitable stellar spindown, thereby lengthening this highly volatile stage of coronal evolution. COordinated Campaign of Observations and Analysis, Photosphere to Upper Atmosphere, of a Fast-rotating Star.

  17. Nurses assessing pain with the Nociception Coma Scale: interrater reliability and validity.

    Science.gov (United States)

    Vink, Peter; Eskes, Anne Maria; Lindeboom, Robert; van den Munckhof, Pepijn; Vermeulen, Hester

    2014-12-01

    The Nociception Coma Scale (NCS) is a pain observation tool, developed for patients with disorders of consciousness (DOC) due to acquired brain injury (ABI). The aim of this study was to assess the interrater reliability of the NCS and NCS-R among nurses for the assessment of pain in ABI patients with DOC. A secondary aim was further validation of both scales by assessing its discriminating abilities for the presence or absence of pain. Hospitalized patients with ABI (n = 10) were recorded on film during three conditions: baseline, after tactile stimulation, and after noxious stimulation. All stimulations were part of daily treatment for these patients. The 30 recordings were assessed with the NCS and NCS-R by 27 nurses from three university hospitals in the Netherlands. Each nurse viewed 9 to 12 recordings, totaling 270 assessments. Interrater reliability of the NCS/NCS-R items and total scores were estimated by intraclass correlations (ICC), which showed excellent and equal average measures reliability for the NCS and NCR-R total scores (ICC 0.95), and item scores (range 0.87-0.95). Secondary analysis was performed to assess differences in ICCs among nurses' education and experience and to assess the scales discriminating properties for the presence of pain. The NCS and NCS-R are valid and reproducible scales that can be used by nurses with an associate (of science) in nursing degree or baccalaureate (of science) in nursing degree. It seems that more experience with ABI patients is not a predictor for good agreement in the assessment of the NCS(-R).

  18. FK COMAE BERENICES, KING OF SPIN: THE COCOA-PUFS PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Ayres, Thomas R. [Center for Astrophysics and Space Astronomy, 389 UCB, University of Colorado, Boulder, CO 80309 (United States); Kashyap, V.; Saar, S.; Drake, J. J.; Testa, P.; Cohen, O.; Garraffo, C. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA (United States); Huenemoerder, D. [Massachusetts Institute of Technology, Cambridge, MA (United States); Korhonen, H. [Finnish Centre for Astronomy with ESO (FINCA), University of Turku, Väisäläntie 20, FI-21500 Piikkiö (Finland); Granzer, T.; Strassmeier, K., E-mail: Thomas.Ayres@Colorado.edu [Leibniz-Institut für Astrophysik Potsdam (AIP), An der Sternwarte 16, D-14482 Potsdam (Germany)

    2016-03-15

    COCOA-PUFS is an energy-diverse, time-domain study of the ultra-fast spinning, heavily spotted, yellow giant FK Comae Berenices (FK Com: HD117555; G4 III). This single star is thought to be a recent binary merger, and is exceptionally active by measure of its intense ultraviolet (UV) and X-ray emissions, and proclivity to flare. COCOA-PUFS was carried out with the Hubble Space Telescope in the UV (1200–3000 Å), using mainly its high-performance Cosmic Origins Spectrograph, but also high precision Space Telescope Imaging Spectrograph; Chandra X-ray Observatory in the soft X-rays (0.5–10 keV), utilizing its High-Energy Transmission Grating Spectrometer; together with supporting photometry and spectropolarimetry in the visible from the ground. This is an introductory report on the project. FK Com displayed variability on a wide range of timescales over all wavelengths during the week-long main campaign, including a large X-ray flare; “super-rotational broadening” of the far-ultraviolet “hot lines” (e.g., Si iv 1393 Å; 8 × 10{sup 4} K) together with chromospheric Mg ii 2800 Å and C ii 1335 Å (1–3 × 10{sup 4} K); large Doppler swings suggestive of bright regions alternately on advancing and retreating limbs of the star; and substantial redshifts of the epoch-average emission profiles. These behaviors paint a picture of a highly extended, dynamic, hot (∼10 MK) coronal magnetosphere around the star, threaded by cooler structures perhaps analogous to solar prominences and replenished continually by surface activity and flares. Suppression of angular momentum loss by the confining magnetosphere could temporarily postpone the inevitable stellar spindown, thereby lengthening this highly volatile stage of coronal evolution.

  19. Dark matter distribution in the Coma cluster from galaxy kinematics: breaking the mass-anisotropy degeneracy

    Science.gov (United States)

    Łokas, Ewa L.; Mamon, Gary A.

    2003-08-01

    We study velocity moments of elliptical galaxies in the Coma cluster using Jeans equations. The dark matter distribution in the cluster is modelled by a generalized formula based upon the results of cosmological N-body simulations. Its inner slope (cuspy or flat), concentration and mass within the virial radius are kept as free parameters, as well as the velocity anisotropy, assumed independent of position. We show that the study of line-of-sight velocity dispersion alone does not allow us to constrain the parameters. By a joint analysis of the observed profiles of velocity dispersion and kurtosis, we are able to break the degeneracy between the mass distribution and velocity anisotropy. We determine the dark matter distribution at radial distances larger than 3 per cent of the virial radius and we find that the galaxy orbits are close to isotropic. Due to limited resolution, different inner slopes are found to be consistent with the data and we observe a strong degeneracy between the inner slope α and concentration c; the best-fitting profiles have the two parameters related with c= 19-9.6α. Our best-fitting Navarro-Frenk-White profile has concentration c= 9, which is 50 per cent higher than standard values found in cosmological simulations for objects of similar mass. The total mass within the virial radius of 2.9h-170 Mpc is 1.4 × 1015h-170 Msolar (with 30 per cent accuracy), 85 per cent of which is dark. At this distance from the cluster centre, the mass-to-light ratio in the blue band is 351h70 solar units. The total mass within the virial radius leads to estimates of the density parameter of the Universe, assuming that clusters trace the mass-to-light ratio and baryonic fraction of the Universe, with Ω0= 0.29 +/- 0.1.

  20. Radial gradients in initial mass function sensitive absorption features in the Coma brightest cluster galaxies

    Science.gov (United States)

    Zieleniewski, Simon; Houghton, Ryan C. W.; Thatte, Niranjan; Davies, Roger L.; Vaughan, Sam P.

    2017-02-01

    Using the Oxford Short Wavelength Integral Field specTrograph, we trace radial variations of initial mass function (IMF)-sensitive absorption features of three galaxies in the Coma cluster. We obtain resolved spectroscopy of the central 5 kpc for the two central brightest cluster galaxies (BCGs) NGC4889, NGC4874, and the BCG in the south-west group NGC4839, as well as unresolved data for NGC4873 as a low-σ* control. We present radial measurements of the IMF-sensitive features: sodium Na ISDSS, calcium triplet CaT, and iron-hydride FeH0.99, along with the magnesium Mg I0.88 and titanium oxide TiO0.89 features. We employ two separate methods for both telluric correction and sky subtraction around the faint FeH feature to verify our analysis. Within NGC4889 we find strong gradients of Na ISDSS and CaT but a flat FeH profile, which, from comparing to stellar population synthesis models, suggests an old, α-enhanced population with a Chabrier, or even bottom-light IMF. The age and abundance are in line with previous studies but the normal IMF is in contrast to recent results suggesting an increased IMF slope with increased velocity dispersion. We measure flat Na ISDSS and FeH profiles within NGC4874, and determine an old, possibly slightly α-enhanced and Chabrier IMF population. We find an α-enhanced, Chabrier IMF population in NGC4873. Within NGC4839 we measure both strong Na ISDSS and strong FeH, although with a large systematic uncertainty, suggesting a possible heavier IMF. The IMFs we infer for these galaxies are supported by published dynamical modelling. We stress that IMF constraints should be corroborated by further spectral coverage and independent methods on a galaxy-by-galaxy basis.

  1. Acute bithalamic infarct manifesting as sleep-like coma: A diagnostic challenge.

    Science.gov (United States)

    Honig, Asaf; Eliahou, Ruth; Eichel, Roni; Shemesh, Ari Aharon; Ben-Hur, Tamir; Auriel, Eitan

    2016-12-01

    Bilateral thalamic infarction (BTI) typically presents as a sleep-like coma (SLC) without localizing signs, posing a diagnostic challenge that may lead the treating physician to search for toxic or metabolic causes and delay treatment. We review our experience with BTI of different etiologies, and emphasize the critical role of timely imaging, diagnosis, and management in a series of 12 patients with a presentation of SLC and acute BTI who were managed in our Medical Centers from 2006-2015. In 11/12, urgent head CT scans showed normal brain tissue, while diffusion-weighted (DWI) MRI revealed symmetric bilateral thalamic hyperintense lesions with variable degrees of brainstem involvement. In 1/12, CT scans revealed a contralateral subacute stroke from a thalamic infarct 1month earlier with a unilateral hyperintense lesion on DWI-MRI. From clinical and imaging findings (DWI-MRI, CT angiography and venography), etiology was attributed to embolic causes (cardio-embolism, artery-to-artery mechanism), small vessel disease, or deep sinus vein thrombosis secondary to dural arteriovenous (AV) fistula. Three patients had good outcomes after prompt diagnosis and optimal treatment in <3hours (intravenous tissue plasminogen activator in two patients cardio-embolic etiology and neuro-endovascular repair in one patient with venous infarction due to a dural AV fistula). The diagnosis was made beyond the therapeutic window in seven patients, who were left with significant neurological sequelae. Higher awareness of BTI presenting as SLC is warranted. Optimal patient management includes urgent DWI-MRI. In cases of BTI, further imaging workup is indicated to provide a comprehensive assessment for etiology. Early diagnosis and prompt, targeted intervention are crucial.

  2. Models of millimeter-wave emission from dust in the coma of Comet 67P

    Science.gov (United States)

    Kareta, Theodore R.; Schloerb, F. Peter

    2017-01-01

    The spacecraft Rosetta ended its mission on September 30th, 2016 after spending more than 2 years studying Comet 67P/Churyumov-Gerasimenko. The comet is constantly emitting gas and ejecting dust as it moves through the inner solar system, and understanding the properties of the gas and dust can help us better understand the comet and its origins. We present the results of a Monte Carlo simulation of dust production developed for comparison with millimeter and submillimeter data obtained by the Microwave Instrument for the Rosetta Orbiter (MIRO). The MIRO instrument measures the millimeter-wave continuum emission from the comet at two wavelengths, 0.53 mm and 1.59 mm. During the months around the August 2015 perihelion of the comet, a small emission excess was observed above the sunlit limb of the comet. The excess emission extends many beam widths off the dayside limb and is a persistent feature for months of observations. No excess is observed above the nightside limb, and given the known strong day-night asymmetry of gas production from the nucleus, we interpret the observed continuum excess on the day side to result from thermal emission from dust. A full treatment of the millimeter-wave emission from the large dust particles observed by MIRO must include many effects, including acceleration of dust particles by outflowing gas and the integration of millimeter-wave emission from a broad range of particle sizes. Our model also incorporates an accurate cometary shape model to demonstrate how dust production might vary with solar illumination over the surface. We find that the complex shape of 67P can lead to asymmetric structures in the distribution of the coma dust, with significant enhancements occurring where large areas of the nucleus have similar orientations with respect to the Sun.

  3. Glasgow coma score and tumor necrosis factor α as predictive criteria for initial poor graft function.

    Science.gov (United States)

    Novelli, G; Morabito, V; Lai, Q; Levi Sandri, G B; Melandro, F; Pugliese, F; Novelli, S; Rossi, M; Berloco, P B

    2012-09-01

    Initial poor graft function (IPGF) is a major factor influencing the clinical outcome after liver transplantation (LT), but there is no reliable method to assess and predict graft dysfunction. To help clinicians determine prognosis in the early postoperative period, individual parameters and complex scoring systems have been suggested, but most of them are inaccurate because of the multifactorial nature of transplantation courses. Therefore, the aim of our study was to retrospectively evaluate predictive criteria for retransplantation. Forty-two patients were enrolled in this study: 18 who experienced primary non-function (PNF) and 24 with delayed graft function (DGF). All of the patients were treated with the Molecular Adsorbent Recirculating System (MARS). They were into 3 subgroups: patients who survived without LT (n = 20; 47.7%); patients who underwent LT (n = 16; 37%), and patients who died before transplantation (n = 6; 14%). Stepwise multivariable logistic regression analysis was performed with the intent to find the risk factors for LT or death after MARS treatment (second analysis). Receiver operating characteristic (ROC) curves were performed on significant variables in the logistic regression model with the intent to individually predict variables for LT or death. After a stepwise multivariable logistic regression analysis enrolling all of the previously reported features only 2 variables, tumor necrosis factor (TFN)-α and Glasgow coma score (GCS) score, were statistically significant. TNF-α was an unique independent risk factor for retransplantation or death after MARS treatment (odds ratio [OR] 1.235; P = .013). Conversely, GCS score was protective against retransplantation or death (OR 0.150; P = .003). Starting from these assumptions, a predictive model was created using these 2 variables. On ROC analysis, the combined score showed an area under the curve greater than that of the 2 variables considered separately. Validating these results with a

  4. TRAUMATIC INTRACRANIAL HAEMORRHAGE: A CORRELATION WITH GLASGOW COMA SCALE, HAEMATOMA VOLUME AND PATIENT PROGNOSIS

    Directory of Open Access Journals (Sweden)

    Srinivasa Babu

    2016-05-01

    Full Text Available BACKGROUND AND PURPOSE To describe the role of Glasgow Coma Scale (GCS as an initial and simple tool of neurological assessment and also haematoma volume in selection of patient for surgery. MATERIALS AND METHODS After an initial GCS assessment, 50 patients with a history of head trauma were referred for a head CT which was done with a GE Bright Speed Elite 16 slice CT scanner. RESULTS 42 patients (84% were males and 8 (16% were females. The mean age was 33.54 years and the maximum numbers of patients affected belonged to the age group of 21 to 30 years. The most common mode of injury in this study was road traffic accident (RTA accounting for 86%. 42% of patients presented with a GCS of

  5. Transmissive liquid-crystal device correcting primary coma aberration and astigmatism in laser scanning microscopy

    Science.gov (United States)

    Tanabe, Ayano; Hibi, Terumasa; Ipponjima, Sari; Matsumoto, Kenji; Yokoyama, Masafumi; Kurihara, Makoto; Hashimoto, Nobuyuki; Nemoto, Tomomi

    2016-03-01

    Laser scanning microscopy allows 3D cross-sectional imaging inside biospecimens. However, certain aberrations produced can degrade the quality of the resulting images. We previously reported a transmissive liquid-crystal device that could compensate for the predominant spherical aberrations during the observations, particularly in deep regions of the samples. The device, inserted between the objective lens and the microscope revolver, improved the image quality of fixed-mouse-brain slices that were observed using two-photon excitation laser scanning microscopy, which was originally degraded by spherical aberration. In this study, we developed a transmissive device that corrects primary coma aberration and astigmatism, motivated by the fact that these asymmetric aberrations can also often considerably deteriorate image quality, even near the sample surface. The device's performance was evaluated by observing fluorescent beads using single-photon excitation laser scanning microscopy. The fluorescence intensity in the image of the bead under a cover slip tilted in the y-direction was increased by 1.5 times after correction by the device. Furthermore, the y- and z-widths of the imaged bead were reduced to 66% and 65%, respectively. On the other hand, for the imaged bead sucked into a glass capillary in the longitudinal x-direction, correction with the device increased the fluorescence intensity by 2.2 times compared to that of the aberrated image. In addition, the x-, y-, and z-widths of the bead image were reduced to 75%, 53%, and 40%, respectively. Our device successfully corrected several asymmetric aberrations to improve the fluorescent signal and spatial resolution, and might be useful for observing various biospecimens.

  6. Poisoning severity score, Glasgow coma scale, corrected QT interval in acute organophosphate poisoning.

    Science.gov (United States)

    Akdur, Okhan; Durukan, Polat; Ozkan, Seda; Avsarogullari, Levent; Vardar, Alper; Kavalci, Cemil; Ikizceli, Ibrahim

    2010-05-01

    The aim of this study was to investigate effectiveness of the poisoning severity score (PSS), Glasgow coma scale (GCS), and corrected QT (QTc) interval in predicting outcomes in acute organophosphates (OP) poisoning. Over a period of 2 years, 62 patients with OP poisoning were admitted to emergency department (ED) of Erciyes University Medical School Hospital. The age, sex, cause of contact, compound involved, time elapsed between exposure and admission to the ED, duration of hospital stay, and cardiac manifestations at the time of presentation were recorded. GCS and poisoning severity score (PSS) was calculated for each patient. Electrocardiogram (ECG) analysis included the rate, rhythm, ST-T abnormalities, conduction defects, and measurement of PR and QT intervals. Sixty-two patients with OP poisoning presented to our ED from January 2007 to December 2008 from which 54 patients were included in the study. The mean age was 34.1 +/- 14.8 years. Of the cases, 53.7% were female. Twenty-six patients had a prolonged QTc interval. Mean PSS of men and women was 1.8 +/- 1.0. No statistically significant correlation was found between the PSS and QTc intervals of the cases. A significant correlation was determined between the GCS and PSS of grade 3 and grade 4 cases. GCS is a parameter that helps clinician to identify advanced grade OP poisoning patients in the initial assessment in the ED. However, ECG findings, such as prolonged QTc interval, are not effective in determination of short-term prognosis and show no relationship with PSS.

  7. Sodium 3D COncentration MApping (COMA 3D) using 23Na and proton MRI

    Science.gov (United States)

    Truong, Milton L.; Harrington, Michael G.; Schepkin, Victor D.; Chekmenev, Eduard Y.

    2014-10-01

    Functional changes of sodium 3D MRI signals were converted into millimolar concentration changes using an open-source fully automated MATLAB toolbox. These concentration changes are visualized via 3D sodium concentration maps, and they are overlaid over conventional 3D proton images to provide high-resolution co-registration for easy correlation of functional changes to anatomical regions. Nearly 5000/h concentration maps were generated on a personal computer (ca. 2012) using 21.1 T 3D sodium MRI brain images of live rats with spatial resolution of 0.8 × 0.8 × 0.8 mm3 and imaging matrices of 60 × 60 × 60. The produced concentration maps allowed for non-invasive quantitative measurement of in vivo sodium concentration in the normal rat brain as a functional response to migraine-like conditions. The presented work can also be applied to sodium-associated changes in migraine, cancer, and other metabolic abnormalities that can be sensed by molecular imaging. The MATLAB toolbox allows for automated image analysis of the 3D images acquired on the Bruker platform and can be extended to other imaging platforms. The resulting images are presented in a form of series of 2D slices in all three dimensions in native MATLAB and PDF formats. The following is provided: (a) MATLAB source code for image processing, (b) the detailed processing procedures, (c) description of the code and all sub-routines, (d) example data sets of initial and processed data. The toolbox can be downloaded at: http://www.vuiis.vanderbilt.edu/~truongm/COMA3D/.

  8. Sodium 3D COncentration MApping (COMA 3D) using (23)Na and proton MRI.

    Science.gov (United States)

    Truong, Milton L; Harrington, Michael G; Schepkin, Victor D; Chekmenev, Eduard Y

    2014-10-01

    Functional changes of sodium 3D MRI signals were converted into millimolar concentration changes using an open-source fully automated MATLAB toolbox. These concentration changes are visualized via 3D sodium concentration maps, and they are overlaid over conventional 3D proton images to provide high-resolution co-registration for easy correlation of functional changes to anatomical regions. Nearly 5000/h concentration maps were generated on a personal computer (ca. 2012) using 21.1T 3D sodium MRI brain images of live rats with spatial resolution of 0.8×0.8×0.8 mm(3) and imaging matrices of 60×60×60. The produced concentration maps allowed for non-invasive quantitative measurement of in vivo sodium concentration in the normal rat brain as a functional response to migraine-like conditions. The presented work can also be applied to sodium-associated changes in migraine, cancer, and other metabolic abnormalities that can be sensed by molecular imaging. The MATLAB toolbox allows for automated image analysis of the 3D images acquired on the Bruker platform and can be extended to other imaging platforms. The resulting images are presented in a form of series of 2D slices in all three dimensions in native MATLAB and PDF formats. The following is provided: (a) MATLAB source code for image processing, (b) the detailed processing procedures, (c) description of the code and all sub-routines, (d) example data sets of initial and processed data. The toolbox can be downloaded at: http://www.vuiis.vanderbilt.edu/~truongm/COMA3D/.

  9. A useful new coma scale in acute stroke patients: FOUR score.

    Science.gov (United States)

    Kocak, Yusuf; Ozturk, Serefnur; Ege, Fahrettin; Ekmekci, Hakan

    2012-01-01

    Assessment of the severity of unconsciousness in patients with impaired consciousness, prediction of mortality and prognosis are currently the most studied subjects in intensive care. The aim of this study was to investigate the usefulness of the Full Outline of UnResponsiveness (FOUR) score in intensive care unit patients with stroke and the associations of FOUR score with the clinical outcome and with other coma scales (Glasgow [GCS] and Acute Physiology and Chronic Health Evaluation II). One hundred acute stroke patients (44 male, 56 female), who were followed in a neurology intensive care unit, were included in this prospective study. The mean age of the patients was 70.49 ± 12.42 years. Lesion types were determined as haemorrhagic in 30 and ischaemic in 70 patients. FOUR scores on the day of admission and the first, third and 10th days of patients who died within 15 days were lower when compared to scores of patients who survived (P=0.005, P=0.000, P=0.000 and P=0.000 respectively). Receiver operating characteristic curve analysis showed significant trending with both FOUR score and GCS for prognosis; the area under curve ranged from 0.675 (95% confidence interval 0.565 to 0.786) when measurements had been made on day 3 to 0.922 (95% confidence interval 0.867 to 0.977) and 0.981 (95% confidence interval 0.947 to 1.015) for day 10. We suggest that FOUR score is a useful scale for evaluation of acute stroke patients in the intensive care unit as a homogeneous group, with respect to the outcome estimation.

  10. Arousal effects of orexin A on acute alcohol intoxication-induced coma in rats.

    Science.gov (United States)

    Jia, Xiaojun; Yan, Jie; Xia, Jianxia; Xiong, Jiaxiang; Wang, Tianhao; Chen, Yuan; Qi, Aiping; Yang, Nian; Fan, Shuangyi; Ye, Jianning; Hu, Zhian

    2012-02-01

    The key role of the hypothalamic neuropeptides orexins in maintenance and promotion of arousal has been well established in normal mammalian animals, but whether orexins exert arousal effects under pathological condition such as coma was little studied. In this study, a model of unconscious rats induced by acute alcohol intoxication was used to examine the effects of orexins through intracerebroventricular injection. The results revealed that either orexin A or orexin B induced decrease of duration of loss of right reflex in alcohol-induced unconscious rats. In the presence of the selective orexin receptor 1 antagonist SB 334867 and orexin receptor 2 antagonist TCS OX2 29, the excitatory action of orexin A was completely blocked. Our data further presented that orexin A also induced reduction of delta power in EEG in these rats. Single-unit recording experiment in vivo demonstrated that orexin A could evoke increase of firing activity of prefrontal cortex neurons in unconscious rats. This excitation was completely inhibited by an H(1) receptor antagonist, pyrilamine, whereas application of α(1)-adrenoreceptor antagonist prazosin or 5-HT(2) selective receptor antagonist ritanserin partially attenuated the excitatory effects of orexin A on these neurons. Consistently, the results of EEG recordings showed that microinjection of pyrilamine, prazosin, or ritanserin suppressed reduction of delta power in EEG induced by orexin A on unconscious rats. Thus, these data suggest that orexins exert arousal effects on alcohol-induced unconscious rats by the promotion of cortical activity through activation of histaminergic, noradrenergic and serotonergic systems. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'.

  11. La coma: un signo en conflicto. Las fallas e inconsistencias más frecuentes en los usos de la coma en la estructuración de textos de opinión de estudiantes universitarios de primer semestre

    OpenAIRE

    Pérez Mora, Elmira del Carmen

    2006-01-01

    El presente estudio examina el manejo de la coma en 18 textos de opinión escritos en español por estudiantes de primer semestre de una universidad pública mexicana. El propósito fue identificar las fallas e inconsistencias más frecuentes en los usos de este signo de puntuación y cómo incide en dicha problemática la falta de claridad con que algunos libros y manuales especializados de redacción y ortografía en español presentan sus diferentes casos. Para tal efecto, se eli...

  12. CONSTRAINING THE DUST COMA PROPERTIES OF COMET C/SIDING SPRING (2013 A1) AT LARGE HELIOCENTRIC DISTANCES

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jian-Yang; Samarasinha, Nalin H. [Planetary Science Institute, 1700 East Fort Lowell Road, Suite 106, Tucson, AZ 85719 (United States); Kelley, Michael S. P.; Farnham, Tony L.; A' Hearn, Michael F. [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Mutchler, Max J. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218-2463 (United States); Lisse, Carey M. [Johns Hopkins University Applied Physics Laboratory, Space Department, 11100 Johns Hopkins Road, Laurel, MD 20723 (United States); Delamere, W. Alan, E-mail: jyli@psi.edu, E-mail: nalin@psi.edu, E-mail: msk@astro.umd.edu, E-mail: farnham@astro.umd.edu, E-mail: ma@astro.umd.edu, E-mail: mutchler@stsci.edu, E-mail: carey.lisse@jpuapl.edu, E-mail: alan@delamere.biz [Delamere Support Service, Boulder, CO 80304 (United States)

    2014-12-10

    The close encounter of comet C/2013 A1 (Siding Spring) with Mars on 2014 October 19 presented an extremely rare opportunity to obtain the first flyby quality data of the nucleus and inner coma of a dynamically new comet. However, the comet's dust tail potentially posed an impact hazard to those spacecraft orbiting Mars. To characterize the comet at large heliocentric distances, study its long-term evolution, and provide critical inputs to hazard modeling, we imaged C/Siding Spring with the Hubble Space Telescope when the comet was at 4.58, 3.77, and 3.28 AU from the Sun. The dust production rate, parameterized by the quantity Afρ, was 2500, 2100, and 1700 cm (5000 km radius aperture) for the three epochs, respectively. The color of the dust coma is (5.0 ± 0.3)%/100 nm for the first two epochs, and (9.0 ± 0.3)%/100 nm for the last epoch, and reddens with increasing cometocentric distance out to ∼3000 km from the nucleus. The spatial distribution and the temporal evolution of the dust color are most consistent with the existence of icy grains in the coma. Two jet-like dust features appear in the northwest and south-southeast directions projected in the sky plane. Within each epoch of 1-2 hr, no temporal variations were observed for either feature, but the position angle of the south-southeastern feature varied between the three epochs by ∼30°. The dust feature morphology suggests two possible orientations for the rotational pole of the nucleus, (R.A., decl.) = (295° ± 5°, +43° ± 2°) and (190° ± 10°, +50° ± 5°), or their diametrically opposite orientations.

  13. Predictive value of neurological examination for early cortical responses to somatosensory evoked potentials in patients with postanoxic coma.

    Science.gov (United States)

    Bouwes, Aline; Binnekade, Jan M; Verbaan, Bart W; Zandbergen, Eveline G J; Koelman, Johannes H T M; Weinstein, Henry C; Hijdra, Albert; Horn, Janneke

    2012-03-01

    Bilateral absence of cortical N20 responses of median nerve somatosensory evoked potentials (SEP) predicts poor neurological outcome in postanoxic coma after cardiopulmonary resuscitation (CPR). Although SEP is easy to perform and available in most hospitals, it is worthwhile to know how neurological signs are associated with SEP results. The aim of this study was to investigate whether specific clinical neurological signs are associated with either an absent or a present median nerve SEP in patients after CPR. Data from the previously published multicenter prospective cohort study PROPAC (prognosis in postanoxic coma, 2000-2003) were used. Neurological examination, consisting of Glasgow Coma Score (GCS) and brain stem reflexes, and SEP were performed 24, 48, and 72 h after CPR. Positive predictive values for predicting absent and present SEP, as well as diagnostic accuracy were calculated. Data of 407 patients were included. Of the 781 SEPs performed, N20 s were present in 401, bilaterally absent in 299, and 81 SEPs were technically undeterminable. The highest positive predictive values (0.63-0.91) for an absent SEP were found for absent pupillary light responses. The highest positive predictive values (0.71-0.83) for a present SEP were found for motor scores of withdrawal to painful stimuli or better. Multivariate analyses showed a fair diagnostic accuracy (0.78) for neurological examination in predicting an absent or present SEP at 48 or 72 h after CPR. This study shows that neurological examination cannot reliably predict absent or present cortical N20 responses in median nerve SEPs in patients after CPR.

  14. X-ray observations of a subhalo associated with the NGC 4839 group infalling toward the Coma cluster

    Science.gov (United States)

    Sasaki, Toru; Matsushita, Kyoko; Sato, Kosuke; Okabe, Nobuhiro

    2016-10-01

    We report on Suzaku X-ray observations of the dark subhalo associated with the merging group of NGC 4839 in the Coma cluster. The X-ray image exhibits an elongated tail toward the southwest. The X-ray peak shifts approximately 1' away from the weak-lensing mass center toward the opposite direction of the Coma cluster center. We investigated the temperature, normalization, pressure, and entropy distributions around the subhalo. Excluding the X-ray tail, the temperature beyond the truncation radius is 8-10 keV, which is twice as high as that of the subhalo and the X-ray tail. The pressure is nearly uniform, excluding the southern part of the subhalo at two times of the truncation radius. We computed the gas mass within the truncation radius and the X-ray tail. While the gas fraction within the truncation radius is about five times smaller than that of regular groups, the gas mass in the subhalo and the X-ray tail to weak-lensing mass ratio is consistent with that of regular groups. Assuming an infall velocity of 2000 km s-1, the ram pressure is 1.4 times greater than the gravitational force per unit area. Assuming the Kelvin-Helmholtz instabilities, the total lost mass is approximately 3 × 1011 M⊙. If this gas had originally been within the truncation radius, the gas mass fraction of the subhalo would have been comparable with those of regular groups before infalling to the Coma cluster.

  15. A 1D Model of Radial Ion Motion Interrupted by Ion–Neutral Interactions in a Cometary Coma

    Science.gov (United States)

    Vigren, E.; Eriksson, A. I.

    2017-04-01

    Because ion–neutral reaction cross sections are energy dependent, the distance from a cometary nucleus within which ions remain collisionally coupled to the neutrals is dictated not only by the comet’s activity level but also by the electromagnetic fields in the coma. Here we present a 1D model simulating the outward radial motion of water group ions with radial acceleration by an ambipolar electric field interrupted primarily by charge transfer processes with H2O. We also discuss the impact of plasma waves. For a given electric field profile, the model calculates key parameters, including the total ion density, n I , the H3O+/H2O+ number density and flux ratios, R dens and R flux, and the mean ion drift speed, , as a function of cometocentric distance. We focus primarily on a coma roughly resembling that of the ESA Rosetta mission target comet 67P/Churyumov–Gerasimenko near its perihelion in 2015 August. In the presence of a weak ambipolar electric field in the radial direction the model results suggest that the neutral coma is not sufficiently dense to keep the mean ion flow speed close to that of the neutrals by the spacecraft location (∼200 km from the nucleus). In addition, for electric field profiles giving n I and within limits constrained by measurements, the R dens values are significantly higher than values typically observed. However, when including the ion motion in large-amplitude plasma waves in the model, results more compatible with observations are obtained. We suggest that the variable and often low H3O+/H2O+ number density ratios observed may reflect nonradial ion trajectories strongly influenced by electromagnetic forces and/or plasma instabilities, with energization of the ion population by plasma waves.

  16. Applicability of different scoring systems in outcome prediction of patients with mixed drug poisoning-induced coma

    Directory of Open Access Journals (Sweden)

    Nastaran Eizadi Mood

    2011-01-01

    Full Text Available Background: Mixed drugs poisoning (MDP is common in the emergency departments. Because of the limited number of intensive care unit beds, recognition of risk factors to divide the patients into different survival groups is necessary. Poisoning due to ingestion of different medications may have additive or antagonistic effects on different parameters included in the scoring systems; therefore, the aim of the study was to compare applicability of the different scoring systems in outcomes prediction of patients admitted with MDP-induced coma. Methods: This prospective, observational study included 93 patients with MDP-induced coma. Clinical and laboratory data conforming to the Acute Physiology and Chronic Health Evaluation (APACHE II, Modified APACHE II Score (MAS, Mainz Emergency Evaluation Scores (MEES and Glasgow Coma Scale (GCS were recorded for all patients on admission (time 0 and 24 h later (time 24 . The outcome was recorded in two categories: Survived with or without complication and non-survived. Discrimination was evaluated using receiver operating characteristic (ROC curves and area under the ROC curve (AUC. Results: The mortality rate was 9.7%. Mean of each scoring system was statistically significant between time 0 and time 24 in the survivors. However, it was not significant in non-survivors. Discrimination was excellent for GCS 24 (0.90±0.05, APACHE II 24 (0.89±0.01, MAS 24 (0.86±0.10, and APACHE II 0 (0.83±0.11 AUC. Conclusion: The GCS 24 , APACHE II 24 , MAS 24 , and APACHE II 0 scoring systems seem to predict the outcome in comatose patients due to MDP more accurately. GCS and MAS may have superiority over the others in being easy to perform and not requiring laboratory data.

  17. 脐血间充质干细胞移植治疗低血糖昏迷1例%Umbilical cord blood mesenchymal stem cells transplantation for treating hypoglycemic coma in one case

    Institute of Scientific and Technical Information of China (English)

    李平; 周瑞; 晏小琼; 余勇飞; 阮清源

    2011-01-01

    背景:成体干细胞可以跨系跨胚层分化为所有的组织细胞类型,在特定的条件下,可分化为骨、软骨、脂肪、肌肉和神经细胞等,替代、修复已受损的组织、细胞,达到功能修复的目的.目的:观察脐血间充质干细胞治疗低血糖昏迷并发缺氧缺血性脑病的疗效.方法:对收治的1 例低血糖昏迷并发缺氧缺血性脑病及肺部感染的患者,给予抗自由基、营养神经、促醒、抗感染、康复理疗等综合治疗的同时,从静脉滴注进行脐血间充质干细胞治疗.观察住院期间意识恢复情况、脑电图、日常生活能力评分及随访结果.结果与结论:治疗近1个月后患者运动、认知功能明显恢复,复查脑电图可及a波,日常生活活动能力评分50分,70 d后随访,患者未出现不良反应,表明干细胞治疗近期疗效安全.提示脐血间充质干细胞治疗低血糖昏迷并发缺氧缺血性脑病安全有效.%BACKGROUND: Adult stem cells can differentiate into all kinds of cell type. Under special conditions, adult stem cells can differentiate into osteoblasts, chond rocytes, adipocytes, muscle cells and neural cells to replace and to repair damaged tissues and cells, to achieve functional recovery purposes.OBJECTIVE: To observe the effect of umbilical cord blood mesenchymal stem cells (UCB-MSCs) therapy in hypoglycemic coma combined with hypoxic ischemic encephalopathy.METHODS: One case of hypoglycemic coma combined with hypoxic ischemic encephalopathy and pulmonary infection was admitted. This patient received a combined treatment, including anti-free radical, nerve-nurturing, consciousness-regaining,anti-infective therapy, rehabilitation and physiotherapy. At the same time, we also gave him the UCB-MSCs therapy by intravenous infusion. The recovery of consciousness, electroencephalogram, activity of daily living and follow-up results were observed during hospital stay.RESULTS AND CONCLUSION: One month later, the

  18. [Contribution of the EEG and evoked potentials in the prognosis of post-anoxic comas in children].

    Science.gov (United States)

    Parain, D; Devaux, A M; Proust, B

    1989-12-01

    Six children with post-anoxic coma were studied and there was evidence of preserved brainstem function together with the presence of electrocerebral activity on EEG. There is no definite prognosis with slow EEG; patients can either die, survive, but with major neurological damage, or recover completely. In that case, evoked potentials have a good prognostic value. Normal BAEP indicate that patients will survive. However, absence of the cortical component of SEP indicates major cerebral damage. Evolution towards a vegetative state can therefore be predicted.

  19. Dust grains in the coma of 67P/Churyumov-Gerasimenko - link with surface properties and cometary activity

    Science.gov (United States)

    Capria, M. T.; Ivanovski, S.; Zakharov, W.; Capaccioni, F.; Filacchione, G.; De Sanctis, M. C.; Rotundi, A.; Della Corte, V.; Longobardo, A.; Palomba, E.; Colangeli, L.; Bockelee-Morvan, D.; Erard, S.; Leyrat, C.

    2016-11-01

    The imaging spectrometer VIRTIS and the dust analyzer GIADA, onboard Rosetta, made an extensive observation of the dust particles in the coma of the comet 67P/Churyumov-Gerasimenko. From the analysis of GIADA data, two different kind of particles have been revealed, compact and fluffy with different compositions and dynamical properties. Compact particles are characterized by densities of about 10E3 kg/m3, while fluffy particles have an almost fractal nature, with densities less than 1 kg/m3. In this work we present the initial results of a model linking the dust flux distribution, as obtained from a theoretical thermal nucleus model, with a model describing the dynamics of aspherical grains in the coma. The results are discussed in the context of the latest observations from VIRTIS and GIADA instruments. The 2D nucleus thermal model, when applied to the real shape of the comet, provides the size distribution and physical properties of the emitted grains at different times and location on the surface. The thermal model can simulate grains of various size distribution, composition and physical properties. This information is used as an input for the dust dynamical model that follows the emitted particles in the coma. The main source of heating is the solar illumination. In the dust dynamical model, the grain trajectory of emitted particles remains in a plane perpendicular to the rotational axis and the direction of illumination is taken to be in the same plane (i.e. does not cause transversal forces). The dust particles are assumed to be isothermal convex bodies and temperature changes only induce modest changes in the aerodynamic force (twice higher temperature changes aerodynamic force less than 30%). This study reviews the theoretical values at which temperature difference starts to play a role on the dynamics. We discuss to what extent the particle's temperature affects the terminal velocities of the dust grains in the 67P coma in dependence on their mass and

  20. First in-situ detection of the cometary ammonium ion NH_4+ (protonated ammonia NH3) in the coma of 67P/C-G near perihelion

    Science.gov (United States)

    Beth, A.; Altwegg, K.; Balsiger, H.; Berthelier, J.-J.; Calmonte, U.; Combi, M. R.; De Keyser, J.; Dhooghe, F.; Fiethe, B.; Fuselier, S. A.; Galand, M.; Gasc, S.; Gombosi, T. I.; Hansen, K. C.; Hässig, M.; Héritier, K. L.; Kopp, E.; Le Roy, L.; Mandt, K. E.; Peroy, S.; Rubin, M.; Sémon, T.; Tzou, C.-Y.; Vigren, E.

    2017-01-01

    In this paper, we report the first in-situ detection of the ammonium ion NH_4+ at 67P/Churyumov-Gerasimenko (67P/C-G) in a cometary coma, using the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) / Double Focusing Mass Spectrometer (DFMS). Unlike neutral and ion spectrometers onboard previous cometary missions, the ROSINA/DFMS spectrometer, when operated in ion mode, offers the capability to distinguish NH_4+ from H2O+ in a cometary coma. We present here the ion data analysis of mass-to-charge ratios 18 and 19 at high spectral resolution and compare the results with an ionospheric model to put the these results into context. The model confirms that the ammonium ion NH_4+ is one of the most abundant ion species, as predicted, in the coma near perihelion.

  1. A Further Investigation of Apparent Periodicities and the Rotational State of Comet 103P/Hartley 2 from Combined Coma Morphology and Lightcurve Datasets

    CERN Document Server

    Knight, Matthew M; Samarasinha, Nalin H; Schleicher, David G

    2015-01-01

    We present an analysis of Kitt Peak National Observatory and Lowell Observatory observations of comet 103P/Hartley 2 obtained from August through December 2010. The results are then compared with contemporaneous observations made by the EPOXI spacecraft. Each ground-based dataset has previously been investigated individually; the combined dataset has complementary coverage that reduces the time between observing runs and allows us to determine additional apparent periods at intermediate times. We compare CN coma morphology between ground-based datasets, making nine new measurements of apparent periods. The first five are consistent with the roughly linearly increasing apparent period during the apparition found by previous authors. The final four suggest that the change in apparent period slowed or stopped by late November. We also measure an inner coma lightcurve in both CN and R-band ground-based images, finding a single-peaked lightcurve which repeats in phase with the coma morphology. The apparent period ...

  2. Photometric redshifts as a tool for studying the Coma cluster galaxy populations

    Science.gov (United States)

    Adami, C.; Ilbert, O.; Pelló, R.; Cuillandre, J. C.; Durret, F.; Mazure, A.; Picat, J. P.; Ulmer, M. P.

    2008-12-01

    Aims: We apply photometric redshift techniques to an investigation of the Coma cluster galaxy luminosity function (GLF) at faint magnitudes, in particular in the u* band where basically no studies are presently available at these magnitudes. Methods: Cluster members were selected based on probability distribution function from photometric redshift calculations applied to deep u^*, B, V, R, I images covering a region of almost 1 deg2 (completeness limit R ~ 24). In the area covered only by the u* image, the GLF was also derived after a statistical background subtraction. Results: Global and local GLFs in the B, V, R, and I bands obtained with photometric redshift selection are consistent with our previous results based on a statistical background subtraction. The GLF in the u* band shows an increase in the faint end slope towards the outer regions of the cluster. The analysis of the multicolor type spatial distribution reveals that late type galaxies are distributed in clumps in the cluster outskirts, where X-ray substructures are also detected and where the GLF in the u* band is steeper. Conclusions: We can reproduce the GLFs computed with classical statistical subtraction methods by applying a photometric redshift technique. The u* GLF slope is steeper in the cluster outskirts, varying from α ~ -1 in the cluster center to α ~ -2 in the cluster periphery. The concentrations of faint late type galaxies in the cluster outskirts could explain these very steep slopes, assuming a short burst of star formation in these galaxies when entering the cluster. Based on observations obtained with MegaPrime/MegaCam, a joint project of CFHT and CEA/DAPNIA, at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council (NRC) of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique (CNRS) of France, and the University of Hawaii. This work is also partly based on data products produced at

  3. Comparison of the Mineralogy of Comet Wild 2 Coma Grains to Other Astromaterials

    Science.gov (United States)

    Frank, David; Zolensky, Michael

    2010-01-01

    We propose that Kuiper Belt samples (in this case comet coma grains from the Jupiter family comet Wild 2) are recognizably different from the bulk of materials in outer belt asteroids, because of their different formation positions and times in the early solar system. We believe this despite similarities found between some Wild 2 grains and components of carbonaceous chondrites (i.e. some CAI and chondrules). Kuiper Belt samples must preserve measurable mineralogical and compositional evidence of formation at unique positions and times in the early solar nebula, and these formational differences must have imparted recognizable special characteristics. We hypothesize that these characteristics include: (1) Unique major element compositional ranges of common astromaterial minerals, especially olivine and pyroxene; (2) Unique minor element compositions of major silicate phases, especially olivine and low-Ca pyroxene; (3) Degree and effects of radiation processing -- including amorphous rims, metal coatings, and Glass with Embedded Metal and Sulfides (GEMS); (4) Presence of abundant presolar silicate grains as recognized by anomalous oxygen in silicates; (5) Oxidation state of the mineral assemblage. We are working our way through all available Wild 2 samples, selecting 1-2 non-consecutive viable TEM grids from each possible extracted Wild 2 grain. We especially prefer TEM grids from grains for which complete mineralogical details have not been published (which is to say the majority of the extracted grains). We are performing a basic mineralogic survey by E-beam techniques, to establish the essential features of the extracted Wild 2 grains. We are making a particular effort to carefully and accurately measure minor elements of olivine and pyroxene, as these minerals are widespread in astromaterials, and comparisons of their compositions will serve to place the Wild 2 silicates in contact with asteroids, meteorites and chondritic interplanetary dust particles

  4. In-hospital mortality and the Glasgow Coma Scale in the first 72 hours after traumatic brain injury Escala de Coma de Glasgow en las primeras 72 horas postrauma encefalocraneano y mortalidad hospitalaria Escala de Coma de Glasgow nas primeiras 72 horas após trauma cranioencefálico e mortalidade hospitalar

    OpenAIRE

    Cristina Helena Costanti Settervall; Regina Marcia Cardoso de Sousa; Silvia Cristina Fürbringer e Silva

    2011-01-01

    This study verifies and compares the performance of three different scores obtained in the Glasgow Coma Scale (GCS) in the first 72 hours post trauma in predicting in-hospital mortality. The studied scores included those obtained after initial care was provided at the hospital, and the worst and best scores obtained in the scale in the first 72 hours post trauma. The scale’s predictive ability was assessed by the Receiver Operator Characteristic (ROC) curve. A total of 277 victims with differ...

  5. Estratégias de ensino-aprendizagem na enfermagem: análise pela Escala de Coma de Glasgow Estrategias de enseñanza y aprendizaje en enfermería: análisis por la Escala de coma de Glasgow Teaching-learning strategies in nursing: analysis using the Glasgow Coma Scale

    OpenAIRE

    Ana Beatriz Pinto da Silva Morita; Maria Sumie Koizumi

    2009-01-01

    Usando como tema a Escala de Coma de Glasgow (ECGl), este estudo objetivou analisar e verificar a retenção do conhecimento frente às estratégias de ensino-aprendizagem e autoaprendizado oferecidas, e verificar o grau de conhecimento adquirido neste processo e a possível associação entre ser ou não aluno que trabalha na enfermagem. Estudo descritivo de abordagem quantitativa. Participaram 62 alunos regularmente matriculados no primeiro semestre do 4º ano de enfermagem. As estratégias de ensino...

  6. Escala de coma de Glasgow e qualidade de vida pós-trauma cranioencefálico Escala de coma de Glasgow y calidad de vida post-trauma craneoencefálico Glasgow Coma Scale and quality of life after traumatic brain injury

    OpenAIRE

    Cristina Helena Costanti Settervall; Regina Marcia Cardoso de Sousa

    2012-01-01

    OBJETIVO: Avaliar o desempenho de diferentes escores da Escala de Coma de Glasgow (ECGl) observados nas primeiras 72 horas pós trauma perante a qualidade de vida e mudança percebida do estado de saúde, após um ano do evento traumático. MÉTODOS: Estudo de abordagem quantitativa, observacional, longitudinal, descritivo e correlacional com vítimas de trauma cranioencefálico contuso (TCEC) avaliadas, diariamente durante a internação hospitalar, e após um ano por meio do Medical Outcome Study 36-i...

  7. Coma-awake prediction model of coma patients with severe traumatic brain injury%重型颅脑损伤昏迷患者的清醒预测模型

    Institute of Scientific and Technical Information of China (English)

    胡栋; 毕学志; 黄富; 肖华

    2013-01-01

    Objective To explore a method that predicts the awakening probability of coma patients with severe traumatic brain injury,and develop models for its clinical application.Methods Clinical data of 263 coma patients with severe traumatic brain injury were analyzed retrospectively.Multinomial logistic regression method was employed to analyze the factors related to prognosis of coma patients with severe traumatic brain injury in early stage,and the models of predicting the awakening probability were established.Results Multinomial logistic regression analysis showed that 6 factors,which included age,pupillary light reflex at admission,movement Glasgow scale (mGCS) scores,whether the brainstem was pressed under CT images,opening time of eyes after treatment,and percentages of ischemic brain volume under CT images,were independent factors to predict the awakening probability of coma patients with severe traumatic brain injury.Pearson Residual evaluation showed that the models have well goodness of fit index.Conclusion The prediction models have well goodness of fit,and predict factors that used in the models are easily to obtain in primly hospitals,so it has a wide range of clinical application prospects in coma patients with severe traumatic brain injury in early stage.%目的 探讨早期预测评估重型颅脑损伤昏迷患者清醒概率的方法,开发预测清醒概率的模型. 方法 回顾性分析南方医科大学附属花都医院神经外科自2010年5月至2012年7月间收治的263例重型颅脑损伤昏迷患者的临床资料,多分类Logistic回归分析与患者清醒预后相关的多种因素,并建立预测清醒概率的模型. 结果 多分类Logistic回归显示年龄、入院时瞳孔对光反射、运动格拉斯哥评分(mGCS)、CT示脑干是否受压,治疗后的睁眼时间和脑缺血体积百分比均为重型颅脑损伤昏迷患者清醒的独立预测因子,Pearson残差评估显示预测模型的拟合效果较佳. 结论 本预

  8. 以意识障碍就诊的低血糖昏迷36例分析%Consciousness disorder treatmen Hypoglycemic coma in 36 cases analysis

    Institute of Scientific and Technical Information of China (English)

    买泓

    2012-01-01

    Objective To investigate hypoglycemic coma in patients with clinical manifestations, treatment and prognosis. Methods in our hospital from 2009January to2011in emergency department patients with hypoglycemic coma in December36 cases for investigation, analysis of induced hypoglycemic coma causes, clinical manifestations, treatment and prognosis. Results 36 cases of patients with hypoglycemic coma after treatment,1 cases died, the remaining 35cases cured and discharged, the cure rate is 97.2%. Conclusion patients with hypoglycemic coma, as soon as possible in order to definitively diagnose, once the diagnosis is clearly a significant treatment effect, so the emergency room patients with coma should be routine detection of blood glucose. And shall regulate the antidiabetic drug use, strengthen the awareness of hypoglycaemia.%目的探讨低血糖昏迷患者的临床表现,治疗方法及预后.方法对我院急诊内科从2009年1月至2011年12月就诊的低血糖昏迷36例患者进行调查,分析引起低血糖昏迷的原因,临床表现,治疗方法及预后.结果36例低血糖昏迷患者经治疗,其中1例死亡,其余35例均好转出院,治愈率97.2%.结论低血糖昏迷患者,应尽快明确诊断为主,一旦诊断明确治疗效果显著,所以对急诊科的昏迷患者应常规检测快速血糖.并应规范降糖药物的使用,加强对低血糖的认识.

  9. 52例肝昏迷患者的急救和护理%First Aid and Nursing Care of 52 Cases of Patients with Hepatic Coma

    Institute of Scientific and Technical Information of China (English)

    李益平; 翁海平; 年素娟; 于静静

    2014-01-01

    Objective To study the first aid and nursing care of patients with hepatic coma and improve the success rate of rescue.Methods Through close observation and emergency care of 52 cases with hepatic coma,conclude the hospital first-aid and nursing care of patients with hepatic coma.Results 46 patients through timely rescue and care get improved and discharge from hospital,6 cases before admission in a coma for more than 48h died.Conclusion Observation and nursing has important significance in treatment of hepatic coma patients. Close observation of state of consciousness with liver diseasepatients,and timely treatment and care before coma, prevent the liver patients from the occurrence of hepatic coma,and hepatic coma rescue was critical to the quality of life of prognosis.%目的探讨肝昏迷患者的急救和护理要点,提高抢救成功率。方法通过对本院52例肝昏迷患者的病情观察和急救护理,总结出肝昏迷患者院内急救和护理的要点。结果46例患者经过及时抢救和精心护理好转出院,6例因入院前昏迷时间超过24h经抢救无效死亡。结论肝昏迷患者的观察和护理在治疗肝昏迷患者中具有重要的意义。严密观察肝病患者的意识状态,出现昏迷前期症状时及早采取相应的治疗和护理,对预防肝昏迷的发生及肝昏迷的抢救,提高预后的生活质量至关重要。

  10. Constraining the Dust Coma Properties of Comet C/Siding Spring (2013 A1) at Large Heliocentric Distances

    CERN Document Server

    Li, Jian-Yang; Kelley, Michael S P; Farnham, Tony L; A'Hearn, Michael F; Mutchler, Max J; Lisse, Carey M; Delamere, W Alan

    2014-01-01

    The close encounter of Comet C/2013 A1 (Siding Spring) with Mars on October 19, 2014 presented an extremely rare opportunity to obtain the first flyby quality data of the nucleus and inner coma of a dynamically new comet. However, the comet's dust tail potentially posed an impact hazard to those spacecraft. To characterize the comet at large heliocentric distances, study its long-term evolution, and provide critical inputs to hazard modeling, we imaged C/Siding Spring with the Hubble Space Telescope when the comet was at 4.58, 3.77, and 3.28 AU from the Sun. The dust production rate, parameterized by the quantity Af$\\rho$, was 2500, 2100, and 1700 cm (5000-km radius aperture) for the three epochs, respectively. The color of the dust coma is 5.0$\\pm$0.3$\\%$/100 nm for the first two epochs, and 9.0$\\pm$0.3$\\%$/100 nm for the last epoch, and reddens with increasing cometocentric distance out to ~3000 km from the nucleus. The spatial distribution and the temporal evolution of the dust color are most consistent wi...

  11. 65 kpc of ionized gas trailing behind NGC 4848 during its first crossing of the Coma cluster

    CERN Document Server

    Fossati, Matteo; Boselli, Alessandro; Fumagalli, Michele

    2012-01-01

    In a 5 hour H{\\alpha} exposure of the N-W region of the Coma cluster with the 2.1m telescope at SPM (Mx) we discovered a 65 kpc cometary emission of ionized gas trailing behind the SBab galaxy NGC 4848. The tail points in the opposite direction of the cluster center, in the same direction where stripped HI has been detected in previous observations. The galaxy shows bright HII regions in an inner ring-like pattern, where the star formation takes place at the prodigious rate of 8.6 Msun/yr. From the morphology of the galaxy and of the trailing material, we infer that the galaxy is suffering from ram pressure due to its high velocity motion through the cluster IGM. We estimate that 4 x 10^9 Msun of gas is swept out from the galaxy forming the tail. Given the ambient conditions in the Coma cluster ({\\rho}0 = 6.3 x 10^-27 g/cm^3; {\\sigma}vel = 940 km/s) simulations predict that the ram pressure mechanism is able to remove such an amount of gas in less than 200 Myr. This, combined with the geometry of the interact...

  12. Comet 81p/Wild 2: The Updated Stardust Coma Dust Fluence Measurement for Smaller (Sub 10-Micrometre) Particles

    Science.gov (United States)

    Price, M. C.; Kearsley, A. T.; Burchell, M. J.; Horz, Friedrich; Cole, M. J.

    2009-01-01

    Micrometre and smaller scale dust within cometary comae can be observed by telescopic remote sensing spectroscopy [1] and the particle size and abundance can be measured by in situ spacecraft impact detectors [2]. Initial interpretation of the samples returned from comet 81P/Wild 2 by the Stardust spacecraft [3] appears to show that very fine dust contributes not only a small fraction of the solid mass, but is also relatively sparse [4], with a low negative power function describing grain size distribution, contrasting with an apparent abundance indicated by the on-board Dust Flux Monitor Instrument (DFMI) [5] operational during the encounter. For particles above 10 m diameter there is good correspondence between results from the DFMI and the particle size inferred from experimental calibration [6] of measured aerogel track and aluminium foil crater dimensions (as seen in Figure 4 of [4]). However, divergence between data-sets becomes apparent at smaller sizes, especially submicrometre, where the returned sample data are based upon location and measurement of tiny craters found by electron microscopy of Al foils. Here effects of detection efficiency tail-off at each search magnification can be seen in the down-scale flattening of each scale component, but are reliably compensated by sensible extrapolation between segments. There is also no evidence of malfunction in the operation of DFMI during passage through the coma (S. Green, personal comm.), so can the two data sets be reconciled?

  13. Stellar Occultations in the Coma of Comet 67/P Chuyumov-Gerasimenko Observed by the OSIRIS Camera System

    Science.gov (United States)

    Moissl, Richard; Kueppers, Michael

    2016-10-01

    In this paper we present the results of an analysis on a large part of the existing Image data from the OSIRIS camera system onboard the Rosetta Spacecraft, in which stars of sufficient brightness (down to a limiting magnitude of 6) have been observed through the coma of Comet 67/P Churyumov-Gerasimenko ("C-G"). Over the course of the Rosetta main mission the Coma of the comet underwent large changes in density and structure, owed to the changing insolation along the orbit of C-G. We report on the changes of the stellar signals in the wavelength ranges, covered by the filters of the OSIRIS Narrow-Angle (NAC) and Wide-Angle (WAC) cameras.Acknowledgements: OSIRIS was built by a consortium led by the Max-Planck-Institut für Sonnensystemforschung, Göttingen, Germany, in collaboration with CISAS, University of Padova, Italy, the Laboratoire d'Astrophysique de Marseille, France, the Instituto de Astrofísica de Andalucia, CSIC, Granada, Spain, the Scientific Support Office of the European Space Agency, Noordwijk, The Netherlands, the Instituto Nacional de Técnica Aeroespacial, Madrid, Spain, the Universidad Politéchnica de Madrid, Spain, the Department of Physics and Astronomy of Uppsala University, Sweden, and the Institut für Datentechnik und Kommunikationsnetze der Technischen Universität Braunschweig, Germany.

  14. Characterizing the Dust Coma of Comet C/2012 S1 (ISON) at 4.15 AU from the Sun

    CERN Document Server

    Li, Jian-Yang; Knight, Matthew M; Farnham, Tony L; Weaver, Harold A; A'Hearn, Michael F; Mutchler, Max J; Kolokolova, Ludmilla; Lamy, Philippe; Toth, Imre

    2013-01-01

    We report results from broadband visible images of comet C/2012 S1 (ISON) obtained with the Hubble Space Telescope Wide Field Camera 3 on 2013 April 10. C/ISON's coma brightness follows a 1/{\\rho} (where {\\rho} is the projected distance from the nucleus) profile out to 5000 km, consistent with a constant speed dust outflow model. The turnaround distance in the sunward direction suggests that the dust coma is composed of sub-micron-sized particles emitted at speeds of tens of meters s$^{-1}$. A({\\theta})f{\\rho}, which is commonly used to characterize the dust production rate, was 1340 and 1240 cm in the F606W and F438W filters, respectively, in apertures 10% per 100 nm 10,000 km down the tail. The colors are similar to those of comet C/1995 O1 (Hale-Bopp) and other long-period comets, but somewhat bluer than typical values for short-period comets. The spatial color variations are also reminiscent of C/Hale-Bopp. A sunward jet is visible in enhanced images, curving to the north and then tailward in the outer co...

  15. X-Ray observations of a subhalo associated with the NGC 4839 group infalling toward the Coma cluster

    CERN Document Server

    Sasaki, Toru; Sato, Kosuke; Okabe, Nobuhiro

    2016-01-01

    We report $Suzaku$ X-ray observations of the dark subhalo associated with the merging group of NGC 4839 in the Coma cluster. The X-ray image exhibits an elongated tail toward the southwest. The X-ray peak shifts approximately $1'$ away from the weak-lensing mass center toward the opposite direction of the Coma cluster center. We investigated the temperature, normalization, pressure, and entropy distributions around the subhalo. Excluding the X-ray tail, the temperature beyond the truncation radius is 8-10$~\\rm keV$, which is two times higher than that of the subhalo and the X-ray tail. The pressure is nearly uniform excluding southern part of the subhalo at two times of the truncation radius. We computed the gas mass within the truncation radius and the X-ray tail. While the gas fraction within the truncation radius is about 5 times smaller than that of regular groups, the gas mass in the subhalo and the X-ray tail to weak-lensing mass ratio is consistent with that of regular groups. Assuming the infall veloc...

  16. GIADA on-board Rosetta: comet 67P/C-G dust coma characterization

    Science.gov (United States)

    Rotundi, Alessandra; Della Corte, Vincenzo; Fulle, Marco; Sordini, Roberto; Ivanovski, Stavro; Accolla, Mario; Ferrari, Marco; Lucarelli, Francesca; Zakharov, Vladimir; Mazzotta Epifani, Elena; López-Moreno, José J.; Rodríguez, Julio; Colangeli, Luigi; Palumbo, Pasquale; Bussoletti, Ezio; Crifo, Jean-Francois; Esposito, Francesca; Green, Simon F.; Grün, Eberhard; Lamy, Philippe L.

    2015-04-01

    21ESA-ESAC, Camino Bajo del Castillo, s/n., Urb. Villafranca del Castillo, 28692 Villanueva de la Cañada, Madrid, Spagna GIADA consists of three subsystems: 1) the Grain Detection System (GDS) to detect dust grains as they pass through a laser curtain, 2) the Impact Sensor (IS) to measure grain momentum derived from the impact on a plate connected to five piezoelectric sensors, and 3) the MicroBalances System (MBS); five quartz crystal microbalances in roughly orthogonal directions providing the cumulative dust flux of grains smaller than 10 microns. GDS provides data on grain speed and its optical cross section. The IS grain momentum measurement, when combined with the GDS detection time, provides a direct measurement of grain speed and mass. These combined measurements characterize single grain dust dynamics in the coma of 67P/CG. No prior in situ dust dynamical measurements at these close distances from the nucleus and starting from such high heliocentric distances are available up to date. We present here the results obtained by GIADA, which began operating in continuous mode on 18 July 2014 when the comet was at a heliocentric distance of 3.7 AU. The first grain detection occurred when the spacecraft was 814 km from the nucleus on 1 August 2014. From August the 1st up to December the 11th, GIADA detected more than 800 grains, for which the 3D spatial distribution was determined. About 700 out of 800 are GDS only detections: "dust clouds", i.e. slow dust grains (≈ 0.5 m/s) crossing the laser curtain very close in time (e.g. 129 grains in 11 s), probably fluffy grains. IS only detections are about 70, i.e. ≈ 1/10 of the GDS only. This ratio is quite different from what we got for the early detections (August - September) when the ration was ≈ 3, suggesting the presence of different types of particle (bigger, brighter, less dense).The combined GDS+IS detections, i.e. measured by both the GDS and IS detectors, are about 70 and allowed us to extract the

  17. Rotation and magnetic activity of the Hertzsprung-gap giant 31 Comae

    Science.gov (United States)

    Strassmeier, K. G.; Granzer, T.; Kopf, M.; Weber, M.; Küker, M.; Reegen, P.; Rice, J. B.; Matthews, J. M.; Kuschnig, R.; Rowe, J. F.; Guenther, D. B.; Moffat, A. F. J.; Rucinski, S. M.; Sasselov, D.; Weiss, W. W.

    2010-09-01

    Context. The single rapidly-rotating G0 giant 31 Comae has been a puzzle because of the absence of photometric variability despite its strong chromospheric and coronal emissions. As a Hertzsprung-gap giant, it is expected to be at the stage of rearranging its moment of inertia, hence likely also its dynamo action, which could possibly be linked with its missing photospheric activity. Aims: Our aim is to detect photospheric activity, obtain the rotation period, and use it for a first Doppler image of the star's surface. Its morphology could be related to the evolutionary status. Methods: We carried out high-precision, white-light photometry with the MOST satellite, ground-based Strömgren photometry with automated telescopes, and high-resolution optical echelle spectroscopy with the new STELLA robotic facility. Results: The MOST data reveal, for the first time, light variations with a full amplitude of 5 mmag and an average photometric period of 6.80 ± 0.06 days. Radial-velocity variations with a full amplitude of 270 m s-1 and a period of 6.76 ± 0.02 days were detected from our STELLA spectra, which we also interpret as due to stellar rotation. The two-year constancy of the average radial velocity of +0.10 ± 0.33 km s-1 confirms the star's single status, as well as the membership in the cluster Melotte 111. A spectrum synthesis gives Teff = 5660 ± 42 K, log g = 3.51 ± 0.09, and [Fe/H] = -0.15 ± 0.03, which together with the revised Hipparcos distance, suggests a mass of 2.6 ± 0.1 M_⊙ and an age of ≈540 Myr. The surface lithium abundance is measured to be nearly primordial. A detection of a strong He i absorption line indicates nonradiative heating processes in the atmosphere. Our Doppler images show a large, asymmetric polar spot, cooler than Teff by ≈1600 K, and several small low-to-mid latitude features that are warmer by ≈300-400 K and are possibly of chromospheric origin. We computed the convective turnover time for 31 Com as a function of depth

  18. Characteristics of Patients with an Abnormal Glasgow Coma Scale in the Prehospital Setting

    Directory of Open Access Journals (Sweden)

    Durant, Edward

    2011-02-01

    Full Text Available Objective: This cross-sectional study describes the characteristics of patients with an abnormal Glasgow Coma Scale (GCS in the prehospital setting.Methods: We reviewed existing prehospital care reports (PCRs in the San Mateo County, California, emergency medical services (EMS database from January 1 to December 31, 2007. Adults age 18 or greater with a documented GCS fit inclusion criteria. We excluded single and multisystem trauma patients, as well as patients in cardiac arrest, respiratory arrest, or listed as deceased from the study. We classified the remaining patients as a normal GCS of 15 or abnormal (defined as less than 15 at any time during paramedic contact, and then further sub-classified into mild (GCS 13-14, moderate (GCS 9-12 or severe (GCS 3-8.Results: Of the 12,235 unique prehospital care record in the database, 9,044 (73.9% met inclusion criteria, comprised of 2,404 (26.6% abnormal GCS patients and 6,640 (73.4% normal GCS patients. In the abnormal GCS category, we classified 1,361 (56.6% patients as mild, 628 (26.1% as moderate, and 415 (17.3% as severe. Where sex was recorded, we identified 1,214 (50.5% abnormal GCS patients and 2,904 (43.7% normal GCS patients as male. Mean age was 65.6 years in the abnormal GCS group and 61.4 in the normal GCS group (p<0.0001. Abnormal GCS patients were more likely to have a history of conditions known to be associated, such as alcohol abuse (odds ratio [OR] 2.3, 95% confidence interval [CI]=2.75-3.00, diabetes (OR 1.34, 95% CI=1.17-1.54, substance abuse (OR 1.6, CI=1.09-2.3, stroke/transient ischemic attack (OR 2.0, CI=1.64-2.5, and seizures (OR 3.0, CI=1.64-2.5. Paramedics established intravenous (IV access on 1,821 (75.7%, OR 1.94, CI=1.74-2.2 abnormal GCS patients and administered medications to 777 (32.3%, OR 1.01, CI=0.92-1.12. Compared to patients with normal GCS, patients with a mildly abnormal GCS were less likely to receive medications (OR 0.61, CI=0.53-0.70 while those with a

  19. The Role of Therapy Education of Islamic Meaning to Overcome Today’s Global Human Crisis

    Directory of Open Access Journals (Sweden)

    Nina Aminah

    2016-02-01

    Full Text Available Modern community are exposed to current issues related to the very complex personality. Islam offers a therapeutic meaning to overcome the global human crisis through the holy Qu’ran. This study aims to provide a qualitative analysis of logotherapy alternative to global human who experience critical conditions such as the door of death (sakaratul maut, acute illnesses, HIV Aids, kidney illness, stroke, coma, depression / stress, due to the hazards, and other refractory disease. The study showed that the therapy of Islamic meaning based on the holy Qur’an is broader and more comprehensive than the meaning therapy by Viktor E. Frankl.

  20. Patients beyond salvation? Various categories of trauma patients with a minimal Glasgow Coma Score

    NARCIS (Netherlands)

    Nijboer, Johanna M. M.; van der Naalt, Joukje; ten Duis, Hendrik-Jan

    2010-01-01

    Introduction: Trauma patients in an unresponsive state upon presentation to the Emergency Department have a poor prognosis. Rapid assessment of injuries combined with life-preserving therapy is required but de. ning the optimal strategy can be complicated when multiple organ systems are involved. Th

  1. The HST/ACS Coma Cluster Survey - III. Structural parameters of galaxies using single Sérsic fits

    Science.gov (United States)

    Hoyos, Carlos; den Brok, Mark; Verdoes Kleijn, Gijs; Carter, David; Balcells, Marc; Guzmán, Rafael; Peletier, Reynier; Ferguson, Henry C.; Goudfrooij, Paul; Graham, Alister W.; Hammer, Derek; Karick, Arna M.; Lucey, John R.; Matković, Ana; Merritt, David; Mouhcine, Mustapha; Valentijn, Edwin

    2011-03-01

    We present a catalogue of structural parameters for 8814 galaxies in the 25 fields of the Hubble Space Telescope/ACS Coma Treasury Survey. Parameters from Sérsic fits to the two-dimensional surface brightness distributions are given for all galaxies from our published Coma photometric catalogue with mean effective surface brightness brighter than 26.0 mag arcsec-2 and brighter than 24.5 mag (equivalent to absolute magnitude -10.5), as given by the fits, all in F814W(AB). The sample comprises a mixture of Coma members and background objects; 424 galaxies have redshifts and of these 163 are confirmed members. The fits were carried out using both the GIM2D and GALFIT codes. We provide the following parameters: galaxy ID, RA, Dec., the total corrected automatic magnitude from the photometric catalogue, the total magnitude of the model (F814WAB), the geometric mean effective radius Re, the mean surface brightness within the effective radius e, the Sérsic index n, the ellipticity and the source position angle. The selection limits of the catalogue and the errors listed for the Sérsic parameters come from extensive simulations of the fitting process using synthetic galaxy models. The agreement between GIM2D and GALFIT parameters is sensitive to details of the fitting procedure; for the settings employed here the agreement is excellent over the range of parameters covered in the catalogue. We define and present two goodness-of-fit indices which quantify the degree to which the image can be approximated by a Sérsic model with concentric, coaxial elliptical isophotes; such indices may be used to objectively select galaxies with more complex structures such as bulge-disc, bars or nuclear components. We make the catalogue available in electronic format at ASTRO-WISE and MAST. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy

  2. The distribution of gas and ions in the inner coma of 67P/Churyumov-Gerasimenko between 3 AU before and after its perihelion

    Science.gov (United States)

    Bodewits, Dennis; Lara, Luisa; La Forgia, Fiorangela; A'Hearn, Michael F.; Knollenberg, Jörg; Lazzarin, Monica; Li, Zhong-Yi; Osiris team

    2016-10-01

    Rosetta explored a regime not accessible before: the inner coma of a low-activity comet at a large range of heliocentric distances. The Wide Angle Camera (WAC) of the OSIRIS instrument on board the Rosetta spacecraft is equipped with several narrowband filters that are centered on the emission lines and bands of various molecules and ions. These filters center on fragment species that are relatively bright and that have been used for numerous comet studies from the ground (e.g. A'Hearn et al. 1995). Surprisingly, we found that outside 2 AU pre-perihelion, the emission in the filters was dominated by emission from dissociative electron impact excitation (Bodewits et al. 2016). Closer to perihelion, higher gas densities reduced electron temperatures in the inner coma and photo-processes drove much if not most of the emission from the comet. Our observations allowed us to study changes in the physical environment of the inner coma, and Rosetta's excursions as far as 1000 km from the surface allowed us to study different regions of the coma.In this contribution, we will summarize the results of our OSIRIS observations from approximately 3 AU before to 3 AU after perihelion.

  3. Predicting the Alpha Comae Berenices Time of Eclipse: How 3 Ambiguous Measurements Out of 609 Caused a 26 Year Binary’s Eclipse to be Missed

    Science.gov (United States)

    2015-11-01

    John A. Merritt Blvd., Box No. 9501, Nashville, TN 37209-1561, USA; gregory.w.henry@gmail.com 3 Anton Pannekoek Institute for Astronomy , University of... INTRODUCTION α Comae Berenices has long been suspected of eclipsing, despite being a 26 year binary, due to the system having an inclination

  4. Elevated transaminases as a predictor of coma in a patient with anorexia nervosa: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Yoshida Shuhei

    2010-09-01

    Full Text Available Abstract Introduction Liver injury is a frequent complication associated with anorexia nervosa, and steatosis of the liver is thought to be the major underlying pathology. However, acute hepatic failure with transaminase levels over 1000 IU/mL and deep coma are very rare complications and the mechanism of pathogenesis is largely unknown. Case presentation A 37-year-old Japanese woman showed features of acute liver failure and hepatic coma which were not associated with hypoglycemia or hyper-ammonemia. Our patient's consciousness was significantly improved with the recovery of liver function and normalization of transaminase levels after administration of nutritional support. Conclusions Our case report demonstrates that transaminase levels had an inverse relationship with the consciousness of our patient, although the pathogenesis of coma remains largely unknown. This indicates that transaminase levels can be one of the key predictors of impending coma in patients with anorexia nervosa. Therefore, frequent monitoring of transaminase levels combined with rigorous treatment of the underlying nutritional deficiency and psychiatric disorder are necessary to prevent this severe complication.

  5. Post-Coma Persons with Extensive Multiple Disabilities Use Microswitch Technology to Access Selected Stimulus Events or Operate a Radio Device

    Science.gov (United States)

    Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Alberti, Gloria; Oliva, Doretta; Megna, Gianfranco; Iliceto, Carla; Damiani, Sabino; Ricci, Irene; Spica, Antonella

    2011-01-01

    The present two studies extended research evidence on the use of microswitch technology by post-coma persons with multiple disabilities. Specifically, Study I examined whether three adults with a diagnosis of minimally conscious state and multiple disabilities could use microswitches as tools to access brief, selected stimulus events. Study II…

  6. Technology-Aided Leisure and Communication Opportunities for Two Post-Coma Persons Emerged from a Minimally Conscious State and Affected by Multiple Disabilities

    Science.gov (United States)

    Lancioni, Giulio E.; O'Reilly, Mark F.; Singh, Nirbhay N.; Sigafoos, Jeff; Buonocunto, Francesca; Sacco, Valentina; Navarro, Jorge; Lanzilotti, Crocifissa; De Tommaso, Marina; Megna, Marisa; Oliva, Doretta

    2013-01-01

    This study assessed technology-aided programs for helping two post-coma persons, who had emerged from a minimally conscious state and were affected by multiple disabilities, to (a) engage with leisure stimuli and request caregiver's procedures, (b) send out and listen to text messages for communication with distant partners, and (c) combine…

  7. Post-Coma Persons with Motor and Communication/Consciousness Impairments Choose among Environmental Stimuli and Request Stimulus Repetitions via Assistive Technology

    Science.gov (United States)

    Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Buonocunto, Francesca; Sacco, Valentina; Colonna, Fabio; Navarro, Jorge; Lanzilotti, Crocifissa; Oliva, Doretta; Megna, Gianfranco

    2010-01-01

    This study assessed whether a program based on microswitch and computer technology would enable three post-coma participants (adults) with motor and communication/consciousness impairments to choose among environmental stimuli and request their repetition whenever they so desired. Within each session, 16 stimuli (12 preferred and 4 non-preferred)…

  8. A Technology-Assisted Learning Setup as Assessment Supplement for Three Persons with a Diagnosis of Post-Coma Vegetative State and Pervasive Motor Impairment

    Science.gov (United States)

    Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Buonocunto, Francesca; Sacco, Valentina; Colonna, Fabio; Navarro, Jorge; Lanzilotti, Crocifissa; Bosco, Andrea; Megna, Gianfranco; De Tommaso, Marina

    2009-01-01

    Post-coma persons in an apparent condition of vegetative state and pervasive motor impairment pose serious problems in terms of assessment and intervention options. A technology-based learning assessment procedure might serve for them as a diagnostic supplement with possible implications for rehabilitation intervention. The learning assessment…

  9. Post-Coma Persons Emerged from a Minimally Conscious State and Showing Multiple Disabilities Learn to Manage a Radio-Listening Activity

    Science.gov (United States)

    Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Colonna, Fabio; Buonocunto, Francesca; Sacco, Valentina; Megna, Marisa; Oliva, Doretta

    2012-01-01

    This study assessed microswitch-based technology to enable three post-coma adults, who had emerged from a minimally conscious state but presented motor and communication disabilities, to operate a radio device. The material involved a modified radio device, a microprocessor-based electronic control unit, a personal microswitch, and an amplified…

  10. The HST/ACS Coma Cluster Survey : X. Nuclear star clusters in low-mass early-type galaxies: scaling relations

    NARCIS (Netherlands)

    Brok, Mark den; Peletier, Reynier F.; Seth, Anil; Balcells, Marc; Dominguez, Lilian; Graham, Alister W.; Carter, David; Erwin, Peter; Ferguson, Henry C.; Goudfrooij, Paul; Guzman, Rafael; Hoyos, Carlos; Jogee, Shardha; Lucey, John; Phillipps, Steven; Puzia, Thomas; Valentijn, Edwin; Verdoes Kleijn, Gijsbert; Weinzirl, Tim

    2014-01-01

    We present scaling relations between structural properties of nuclear star clusters and their host galaxies for a sample of early-type dwarf galaxies observed as part of the Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) Coma Cluster Survey. We have analysed the light profiles of 200

  11. The HST/ACS Coma Cluster Survey - X. Nuclear star clusters in low-mass early-type galaxies : scaling relations

    NARCIS (Netherlands)

    den Brok, Mark; Peletier, Reynier F.; Seth, Anil; Balcells, Marc; Dominguez, Lilian; Graham, Alister W.; Carter, David; Erwin, Peter; Ferguson, Henry C.; Goudfrooij, Paul; Guzman, Rafael; Hoyos, Carlos; Jogee, Shardha; Lucey, John; Phillipps, Steven; Puzia, Thomas; Valentijn, Edwin; Kleijn, Gijs Verdoes; Weinzirl, Tim

    2014-01-01

    We present scaling relations between structural properties of nuclear star clusters and their host galaxies for a sample of early-type dwarf galaxies observed as part of the Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) Coma Cluster Survey. We have analysed the light profiles of 200

  12. Constraints on Cosmic Rays, Magnetic Fields, and Dark Matter from Gamma-ray Observations of the Coma Cluster of Galaxies with VERITAS and FERMI

    Science.gov (United States)

    Arlen, T.; Aune, T.; Beilicke, M.; Benbow, W.; Bouvier, A.; Buckley, J. H.; Bugaev, V.; Byrum, K.; Cannon, A.; Cesarini, A.; Ciupik, L.; Collins-Hughes, E.; Connolly, M. P.; Cui, W.; Dickherber, R.; Dumm, J.; Falcone, A.; Federici, S.; Feng, Q.; Finley, J. P.; Finnegan, G.; Fortson, L.; Furniss, A.; Galante, N.; Perkins, J. S.

    2012-01-01

    Observations of radio halos and relics in galaxy clusters indicate efficient electron acceleration. Protons should likewise be accelerated and, on account of weak energy losses, can accumulate, suggesting that clusters may also be sources of very high energy (VHE; E greater than100 GeV) gamma-ray emission. We report here on VHE gamma-ray observations of the Coma galaxy cluster with the VERITAS array of imaging Cerenkov telescopes, with complementing Fermi Large Area Telescope observations at GeV energies. No significant gamma-ray emission from the Coma Cluster was detected. Integral flux upper limits at the 99 confidence level were measured to be on the order of (2-5) x 10(sup -8) photons m(sup -2) s(sup -1) (VERITAS,greater than 220 GeV) and approximately 2 x 10(sup -6) photons m(sup -2) s(sup -1) (Fermi, 1-3 GeV), respectively. We use the gamma-ray upper limits to constrain cosmic rays (CRs) and magnetic fields in Coma. Using an analytical approach, the CR-to-thermal pressure ratio is constrained to be less than 16% from VERITAS data and less than 1.7% from Fermi data (averaged within the virial radius). These upper limits are starting to constrain the CR physics in self-consistent cosmological cluster simulations and cap the maximum CR acceleration efficiency at structure formation shocks to be 50. Alternatively, this may argue for non-negligible CR transport processes such as CR streaming and diffusion into the outer cluster regions. Assuming that the radio-emitting electrons of the Coma halo result from hadronic CR interactions, the observations imply a lower limit on the central magnetic field in Coma of approximately (2-5.5)microG, depending on the radial magnetic field profile and on the gamma-ray spectral index. Since these values are below those inferred by Faraday rotation measurements in Coma (for most of the parameter space), this renders the hadronic model a very plausible explanation of the Coma radio halo. Finally, since galaxy clusters are dark

  13. A new 3D multi-fluid model: a study of kinetic effects and variations of physical conditions in the cometary coma

    Science.gov (United States)

    Shou, Yinsi; Combi, Michael R.; Toth, Gabor; Huang, Zhenguang; Jia, Xianzhe; Fougere, Nicolas; Tenishev, Valeriy; Gombosi, T. I.; Hansen, Kenneth C.; Bieler, Andre

    2016-10-01

    Physics-based numerical coma models are desirable whether to interpret the spacecraft observations of the inner coma or to compare with the ground-based observations of the outer coma. In this work, we develop a multi-neutral-fluid model based on BATS-R-US in the University of Michigan's SWMF (Space Weather Modeling Framework), which is capable of computing both the inner and the outer coma and simulating time-variable phenomena. It treats H2O, OH, H2, O, and H as separate fluids and each fluid has its own velocity and temperature, with collisions coupling all fluids together. The self-consistent collisional interactions decrease the velocity differences, re-distribute the excess energy deposited by chemical reactions among all species, and account for the varying heating efficiency under various physical conditions. Recognizing that the fluid approach has limitations in capturing all of the correct physics for certain applications, especially for very low density environment, we applied our multi-fluid coma model to comet 67P/Churyumov–Gerasimenko (CG) at various heliocentric distances and demonstrated that it is able to yield comparable results as the Direct Simulation Monte Carlo (DSMC) model, which is based on a kinetic approach that is valid under these conditions. Therefore, our model may be a powerful alternative to the particle-based model, especially for some computationally intensive simulations. In addition, by running the model with several combinations of production rates and heliocentric distances, we can characterize the cometary H2O expansion speeds and demonstrate the nonlinear effect of production rates or photochemical heating. Our results are also compared to previous modeling work (e.g., Bockelee-Morvan & Crovisier 1987) and remote observations (e.g., Tseng et al. 2007), which serve as further validation of our model. This work has been partially supported by grant NNX14AG84G from the NASA Planetary Atmospheres Program, and US Rosetta

  14. A New 3D Multi-fluid Model: A Study of Kinetic Effects and Variations of Physical Conditions in the Cometary Coma

    Science.gov (United States)

    Shou, Y.; Combi, M.; Toth, G.; Tenishev, V.; Fougere, N.; Jia, X.; Rubin, M.; Huang, Z.; Hansen, K.; Gombosi, T.; Bieler, A.

    2016-12-01

    Physics-based numerical coma models are desirable whether to interpret the spacecraft observations of the inner coma or to compare with the ground-based observations of the outer coma. In this work, we develop a multi-neutral-fluid model based on the BATS-R-US code of the University of Michigan, which is capable of computing both the inner and outer coma and simulating time-variable phenomena. It treats H2O, OH, H2, O, and H as separate fluids and each fluid has its own velocity and temperature, with collisions coupling all fluids together. The self-consistent collisional interactions decrease the velocity differences, re-distribute the excess energy deposited by chemical reactions among all species, and account for the varying heating efficiency under various physical conditions. Recognizing that the fluid approach has limitations in capturing all of the correct physics for certain applications, especially for very low density environment, we applied our multi-fluid coma model to comet 67P/Churyumov-Gerasimenko at various heliocentric distances and demonstrated that it yields comparable results to the Direct Simulation Monte Carlo (DSMC) model, which is based on a kinetic approach that is valid under these conditions. Therefore, our model may be a powerful alternative to the particle-based model, especially for some computationally intensive simulations. In addition, by running the model with several combinations of production rates and heliocentric distances, we characterize the cometary H2O expansion speeds and demonstrate the nonlinear dependencies of production rate and heliocentric distance. Our results are also compared to previous modeling work and remote observations, which serve as further validation of our model.

  15. Immediate and Long-Term Outcome of Acute H2S Intoxication Induced Coma in Unanesthetized Rats: Effects of Methylene Blue

    Science.gov (United States)

    Sonobe, Takashi; Chenuel, Bruno; Cooper, Timothy K.; Haouzi, Philippe

    2015-01-01

    Background Acute hydrogen sulfide (H2S) poisoning produces a coma, the outcome of which ranges from full recovery to severe neurological deficits. The aim of our study was to 1- describe the immediate and long-term neurological effects following H2S-induced coma in un-anesthetized rats, and 2- determine the potential benefit of methylene blue (MB), a compound we previously found to counteract acute sulfide cardiac toxicity. Methods NaHS was administered IP in un-sedated rats to produce a coma (n = 34). One minute into coma, the rats received MB (4 mg/kg IV) or saline. The surviving rats were followed clinically and assigned to Morris water maze (MWM) and open field testing then sacrificed at day 7. Results Sixty percent of the non-treated comatose rats died by pulseless electrical activity. Nine percent recovered with neurological deficits requiring euthanasia, their brain examination revealed major neuronal necrosis of the superficial and middle layers of the cerebral cortex and the posterior thalamus, with variable necrosis of the caudate putamen, but no lesions of the hippocampus or the cerebellum, in contrast to the typical distribution of post-ischemic lesions. The remaining animals displayed, on average, a significantly less effective search strategy than the control rats (n = 21) during MWM testing. Meanwhile, 75% of rats that received MB survived and could perform the MWM test (P<0.05 vs non-treated animals). The treated animals displayed a significantly higher occurrence of spatial search than the non-treated animals. However, a similar proportion of cortical necrosis was observed in both groups, with a milder clinical presentation following MB. Conclusion In conclusion, in rats surviving H2S induced coma, spatial search patterns were used less frequently than in control animals. A small percentage of rats presented necrotic neuronal lesions, which distribution differed from post-ischemic lesions. MB dramatically improved the immediate survival and spatial

  16. Immediate and Long-Term Outcome of Acute H2S Intoxication Induced Coma in Unanesthetized Rats: Effects of Methylene Blue.

    Directory of Open Access Journals (Sweden)

    Takashi Sonobe

    Full Text Available Acute hydrogen sulfide (H2S poisoning produces a coma, the outcome of which ranges from full recovery to severe neurological deficits. The aim of our study was to 1--describe the immediate and long-term neurological effects following H2S-induced coma in un-anesthetized rats, and 2--determine the potential benefit of methylene blue (MB, a compound we previously found to counteract acute sulfide cardiac toxicity.NaHS was administered IP in un-sedated rats to produce a coma (n = 34. One minute into coma, the rats received MB (4 mg/kg i.v. or saline. The surviving rats were followed clinically and assigned to Morris water maze (MWM and open field testing then sacrificed at day 7.Sixty percent of the non-treated comatose rats died by pulseless electrical activity. Nine percent recovered with neurological deficits requiring euthanasia, their brain examination revealed major neuronal necrosis of the superficial and middle layers of the cerebral cortex and the posterior thalamus, with variable necrosis of the caudate putamen, but no lesions of the hippocampus or the cerebellum, in contrast to the typical distribution of post-ischemic lesions. The remaining animals displayed, on average, a significantly less effective search strategy than the control rats (n = 21 during MWM testing. Meanwhile, 75% of rats that received MB survived and could perform the MWM test (P<0.05 vs non-treated animals. The treated animals displayed a significantly higher occurrence of spatial search than the non-treated animals. However, a similar proportion of cortical necrosis was observed in both groups, with a milder clinical presentation following MB.In conclusion, in rats surviving H2S induced coma, spatial search patterns were used less frequently than in control animals. A small percentage of rats presented necrotic neuronal lesions, which distribution differed from post-ischemic lesions. MB dramatically improved the immediate survival and spatial search strategy in the

  17. DRUG INDUCED HYPOGLYCEMIC COMA IN A NONDIABETIC WITH CHRONIC LIVER DISEASE: A CASE REPORT OF DRUG DISPENSING ERROR

    Directory of Open Access Journals (Sweden)

    Krishna M

    2014-08-01

    Full Text Available Hypoglycemia is a common, potentially fatal, yet preventable problem. Drug-induced hypoglycemia remains the commonest cause of hypoglycemia. A 63 year old non-diabetic male, a known case of chronic liver disease, on regular medications, presented with unconsciousness, unresponsiveness since two hours. Immediate random blood sugar was 11 mg/dl. On proper history and clinical examination, diagnosis of oral hypoglycemic agent induced hypoglycemic coma was made and immediately intravenous dextrose resuscitation was started. Patient regained consciousness after four hours and became fully oriented after 24 hours. Throughout his hospital course, strict and frequent glucose monitoring was done and dextrose infused accordingly. Patient remained hemodynamically stable throughout the hospital course. He was discharged from the hospital after 72 hours in an otherwise healthy condition. Drug induced hypoglycemia is now so relatively common that virtually every unconscious patient should be considered hypoglycemic until immediate estimation of the blood sugar level rules the condition in or out.

  18. NARROW DUST JETS IN A DIFFUSE GAS COMA: A NATURAL PRODUCT OF SMALL ACTIVE REGIONS ON COMETS

    Energy Technology Data Exchange (ETDEWEB)

    Combi, M. R.; Tenishev, V. M.; Rubin, M.; Fougere, N.; Gombosi, T. I., E-mail: mcombi@umich.edu [Department of Atmospheric, Oceanic and Space Sciences, University of Michigan, 2455 Hayward Street, Ann Arbor, MI 48109-2143 (United States)

    2012-04-10

    Comets often display narrow dust jets but more diffuse gas comae when their eccentric orbits bring them into the inner solar system and sunlight sublimates the ice on the nucleus. Comets are also understood to have one or more active areas covering only a fraction of the total surface active with sublimating volatile ices. Calculations of the gas and dust distribution from a small active area on a comet's nucleus show that as the gas moves out radially into the vacuum of space it expands tangentially, filling much of the hemisphere centered on the active region. The dust dragged by the gas remains more concentrated over the active area. This explains some puzzling appearances of comets having collimated dust jets but more diffuse gaseous atmospheres. Our test case is 67P/Churyumov-Gerasimenko, the Rosetta mission target comet, whose activity is dominated by a single area covering only 4% of its surface.

  19. Typology of dust particles collected by the COSIMA mass spectrometer in the inner coma of 67P/Churyumov Gerasimenko

    Science.gov (United States)

    Langevin, Y.; Hilchenbach, M.; Ligier, N.; Merouane, S.; Hornung, K.; Engrand, C.; Schulz, R.; Kissel, J.; Rynö, J.; Eng, P.

    2016-06-01

    The COSIMA mass spectrometer on board the ROSETTA orbiter has collected dust in the near coma of comet 67P/Churyumov-Gerasimenko since August 11, 2014. The collected dust particles are identified by taking images with a microscope (COSISCOPE) under grazing incidence illumination before and after exposure of the target to cometary dust. More than 10,000 dust particles >14 μm in size collected from August 11, 2014 to April 3, 2015 have been detected on three distinct target assemblies, including ˜500 dust particles with sizes ranging from 50 to more than 500 μm, that can be resolved by COSISCOPE (pixel size 14 μm). During this period, the heliocentric distance decreased from 3.5 AU to less than 2 AU. The collection efficiency on targets covered with "metal black" has been very high, due to the low relative velocity of incoming dust. Therefore, the COSISCOPE observations provide the first optical characterization of an unbiased sample of particles collected in the inner coma of a comet. The typology of particles >100 μm in size is dominated by clusters with a wide range of structure and strength, most originating from the disruption of large aggregates (>1 mm in size) shortly before collection. A generic relationship between these clusters and IDPs/Antarctic meteorites is likely in the framework of accretion models. About 15% of particles larger than 100 μm are compact particles with two likely contributions, one being linked to clusters and another leaving the cometary nucleus as single compact particles.

  20. CN and OH emissions in the 67P/Churyumov-Gerasimenko coma with Rosetta/VIRTIS-M spectrometer

    Science.gov (United States)

    Migliorini, A.; Filacchione, G.; Capaccioni, F.; Piccioni, G.; Bockelee-Morvan, D.; Erard, S.; Leyrat, C.; Combi, M.; Fougere, N.

    2016-11-01

    Observations with the visible channel of the Visible and InfraRed Thermal Imaging Spectrometer (VIRTIS) on board Rosetta taken when the spacecraft was at a distance of 80-140 km from 67P/Churyumov-Gerasimenko (67P/C-G) allowed the detection of daughter gaseous species in its inner coma. The detection of the violet doublet emission of CN at 388.3 nm has occurred during the coma monitoring campaign in November-December 2015, when the instrument has operated with long integration times (50 s) necessary to boost the instrumental SNR and detect these faint emissions. Other features, like the C3 and C2 signatures around 420-480 nm, might possibly be visible in few cases but with a very low intensity. For this reason, we concentrate our analysis in the spectral region from 250 to 450 nm, where the detector sensitivity allows the positive detection of the above mentioned CN violet line at 388.3 nm, and the OH doublet emission at 309 nm. The CN emission at 388.3 nm is observed on both the day and night sides of 67P/C-G with a higher intensity on the dayside. In addition, at a preliminary analysis, the hydroxyl doublet emission intensity seems to be comparable to the violet CN line. The same emissions were also identified in spectra acquired using ground-based facilities, when the comet had just passed the perihelion (Fitzsimmons et al., 2016). These gaseous species emissions appear well contrasted with respect to the dust broad continuum, preferentially observed on the dayside. Distribution and variability of the OH and CN band intensities will be discussed with respect to observation parameters.

  1. Reduced brain levels of DHEAS in hepatic coma patients: significance for increased GABAergic tone in hepatic encephalopathy.

    Science.gov (United States)

    Ahboucha, Samir; Talani, Giuseppe; Fanutza, Tomas; Sanna, Enrico; Biggio, Giovanni; Gamrani, Halima; Butterworth, Roger F

    2012-07-01

    Increased neurosteroids with allosteric modulatory activity on GABA(A) receptors such as 3α-5α tertrahydroprogesterone; allopregnanolone (ALLO), are candidates to explain the phenomenon of "increased GABAergic tone" in hepatic encephalopathy (HE). However, it is not known how changes of other GABA(A) receptor modulators such as dehydroepiandrosterone sulfate (DHEAS) contribute to altered GABAergic tone in HE. Concentrations of DHEAS were measured by radioimmunoassay in frontal cortex samples obtained at autopsy from 11 cirrhotic patients who died in hepatic coma and from an equal number of controls matched for age, gender, and autopsy delay intervals free from hepatic or neurological diseases. To assess whether reduced brain DHEAS contributes to increased GABAergic tone, in vitro patch clamp recordings in rat prefrontal cortex neurons were performed. A significant reduction of DHEAS (5.81±0.88 ng/g tissue) compared to control values (9.70±0.79 ng/g, p<0.01) was found. Brain levels of DHEAS in patients with liver disease who died without HE (11.43±1.74 ng/g tissue), and in a patient who died in uremic coma (12.56 ng/g tissue) were within the control range. Increasing ALLO enhances GABAergic tonic currents concentration-dependently, but increasing DHEAS reduces these currents. High concentrations of DHEAS (50 μM) reduce GABAergic tonic currents in the presence of ALLO, whereas reduced concentrations of DHEAS (1 μM) further stimulate these currents. These findings demonstrate that decreased concentrations of DHEAS together with increased brain concentrations of ALLO increase GABAergic tonic currents synergistically; suggesting that reduced brain DHEAS could further increase GABAergic tone in human HE.

  2. Clinical Presentation Of The Abuse Of Insulin: Hypoglycaemic Coma And Aspiration Pneumonia In Non-Professional Bodybuilders

    Directory of Open Access Journals (Sweden)

    Petrovic Ivica

    2015-12-01

    Full Text Available The use of medications that improve the physical performance of an individual represents a very serious worldwide health problem. The abuse of these medications is increasing. Herein, we describe a patient, at the age of 20, who was hospitalized due to loss of consciousness and difficulty breathing. At admission, the patient was unconsciousness, tahi-dyspnoic, and had a pale complexion and an athletic build. In gas analyses, extremely low saturation was observed, followed by acidosis, heavy hypoxia with normocapnia, higher lactates, hypocalcaemia and severe hypoglycaemia. The patient was treated with a hypertonic solution of glucose and intubated, with the aspiration of sanious content from the respiratory tract. After treatment, the patient woke from coma but was very confused. In the first 6 hours of hospitalization, severe hypoglycaemia occurred several times, despite the continuous administration of glucose. Due to the growth of inflammatory syndrome since the first day of hospitalization, the patient was kept in the hospital for treatment along with the administration of antibiotic treatment. On the fourth day of hospitalization, the patient stated that for the last year, he had been taking testosterone at a dose of 1 g a week, as well as tamoxifen pills and 15 i.j. of fast-acting human insulin (Actrapid® daily for their combined anabolic effect. Hypoglycaemic coma, caused by the abuse of insulin, represents a severe complication in patients, which can be followed by confusion, a slowed thinking process, the weakening of cognitive functions and even death. It is necessary to invest great efforts into the prevention of the purchase of these medications via the Internet or on the black market for purposes of abuse in order to prevent such serious and life-threatening complications.

  3. [Shock therapy and psychosurgery in the early German Democratic Republic (GDR)].

    Science.gov (United States)

    Rzesnitzek, L

    2015-11-01

    Patient files, textbooks and published articles of the time show that the wide range of psychiatric therapies of the 1950s and 1960s was also used in the early German Democratic Republic (GDR). The use of insulin coma therapy, cardiazol and electroconvulsive therapies and especially of leucotomy in the GDR must not only be seen in the context of the international development and debate concerning these therapies up to the introduction of psychopharmaceutic therapy but also, in a similar way as in the Federal Republic of Germany, in relation to the locally sometimes different availability of insulin and cardiazol in the post-war period, different schools of academic thought and scientific research interest and priorities of the clinics concerned.

  4. Galveston Orientation and Amnesia Test: applicability and relation with the Glasgow Coma Scale Galveston Orientation and Amnesia Test: aplicabilidad y relación con la Escala de Coma de Glasgow Galveston Orientation and Amnesia Test: aplicabilidade e relação com a Escala de Coma de Glasgow

    Directory of Open Access Journals (Sweden)

    Silvia Cristina Fürbringer e Silva

    2007-08-01

    Full Text Available Restrictions in the application of the Galveston Orientation and Amnesia Test and questionings about the relationship between conscience and post-traumatic amnesia motivated this study, which aims to identify, through the Glasgow Coma Scale scores, when to initiate the application of this amnesia test, as well to verify the relationship between the results of these two indicators. The longitudinal prospective study was carried at a referral center for trauma care in São Paulo - Brazil. The sample consisted of 73 victims of blunt traumatic brain injury, admitted at this institution between January 03rd and May 03rd 2001. Regarding the applicability, the test could be applied in patients with a Glasgow Coma Scale score > 12; however, the end of post traumatic amnesia was verified in patients who scored > 14 on the scale. A significant relationship (r s = 0.65 was verified between these measures, although different kinds of relationship between the end of the amnesia and changes in consciousness were observed.Restricciones en la aplicación del Galveston Orientation and Amnesia Test y los cuestionamientos sobre la relación entre conciencia y amnesia post-traumática motivaron este estudio que visa identificar, a través de la puntuación de la Escala de Coma de Glasgow, el periodo más adecuado para la aplicación de la prueba de amnesia, y observar la relación entre los resultados de esos dos indicadores. El estudio prospectivo y longitudinal fue realizado en un centro de referencia para traumas en São Paulo - Brasil. El número fue de 73 victimas de trauma craneoencefálico contuso, internadas en esta institución en el periodo de 03/01 a 03/05/2001. Con relación a la aplicabilidad, la prueba puede ser aplicada en los pacientes con la Escala de Coma de Glasgow > 12, pero el término de la amnesia post-traumática fue observado en los pacientes con puntuación > 14 en la escala. Correlación significativa (rs = 0,65 fue observada entre esas

  5. COMAS烘丝机整体改造与应用%Rebuilding of COMAS Cut Tobacco Dryer

    Institute of Scientific and Technical Information of China (English)

    徐伟民; 刘剑敏; 舒梦; 徐荣华

    2011-01-01

    浙江中烟工业有限责任公司下设两个生产基地,分别配备COMAS逆流式烘丝机和HAUNI顺流式烘丝机.为了克服烘丝机设备和叶丝干燥工艺差异、统一制丝生产工艺、实现不同产地产品的同质化,在对比分析了两种烘丝机工作原理和控制方式的基础上,对COMAS烘丝机进行了整体改造.内容包括:热风流向变为顺流式;风机增加变频调速功能,调节热风流量,减少能源消耗;采用HAUNI方式的热风温度与筒壁温度控制方式;在出料端安装负压传感器保持烘丝机进出风量平衡.改造后的COMAS烘丝机的热风流向、控制方式趋近于HAUNI顺流式烘丝机,各项工艺和物理指标均达到或优于改造前水平,烘丝冷却后含水率控制稳定,含水率偏差控制在0.18%以内,有效控制了干头干尾烟丝量,且减少了蒸汽消耗.%COMAS counter current cut tobacco dryer and HAUNI cocurrent cut tobacco dryer were separately used in two manufacturing facilities of China Tobacco Zhejiang Industrial Limited Corporation.In order to unify processing technology and quality of products, the working principles and control systems of the two dryers were compared and COMAS dryer was rebuilt as following; changing hot-air direction from counter current into cocurrent; adding a frequency conversion speed regulator to hot-air fan motor to adjust air volume and reduce energy consumption; the temperatures of hot-air and cylinder wall being controlled in the same way as that in HAUNI dryer; installing negative pressure sensor at output end to balance the input and output air flow.The rebuilt COMAS dryer showed better performance.The moisture content in dried cut tobacco after cooling was stable, and its deviation was under 0.18%.In addition, the amount of over-dried cut tobacco during start and finish of drying operation was effectively controlled and steam consumption was also reduced.

  6. Hormone Therapy

    Science.gov (United States)

    ... types of estrogen therapy relieve vaginal dryness. • Systemic estrogen protects against the bone loss that occurs early in menopause and helps prevent hip and spine fractures. • Combined estrogen and progestin therapy may reduce the risk of ...

  7. Proton Therapy

    Science.gov (United States)

    ... IMRT) Brain Tumor Treatment Brain Tumors Prostate Cancer Lung Cancer Treatment Lung Cancer Head and Neck Cancer Images related to Proton Therapy Videos related to Proton Therapy Sponsored by Please ...

  8. Radiation Therapy

    Science.gov (United States)

    ... the area is stitched shut. Another treatment, called proton-beam radiation therapy , focuses the radiation on the ... after radiation treatment ends. Sore mouth and tooth decay. If you received radiation therapy to the head ...

  9. Family Therapy

    Science.gov (United States)

    ... may be credentialed by the American Association for Marriage and Family Therapy (AAMFT). Family therapy is often short term. ... challenging situations in a more effective way. References Marriage and family therapists: The friendly mental health professionals. American Association ...

  10. Measurements of the Near-Nucleus Coma of Comet 67P/Churyumov-Gerasimenko with the Alice Far-Ultraviolet Spectrograph on Rosetta

    CERN Document Server

    Feldman, Paul D; Bertaux, Jean-Loup; Feaga, Lori M; Parker, Joel Wm; Schindhelm, Eric; Steffl, Andrew J; Stern, S Alan; Weaver, Harold A; Sierks, Holger; Vincent, Jean-Baptiste

    2015-01-01

    Aims. The Alice far-ultraviolet spectrograph onboard Rosetta is designed to observe emissions from various atomic and molecular species from within the coma of comet 67P/ Churyumov-Gerasimenko and to determine their spatial distribution and evolution with time and heliocentric distance. Methods. Following orbit insertion in August 2014, Alice made observations of the inner coma above the limbs of the nucleus of the comet from cometocentric distances varying between 10 and 80 km. Depending on the position and orientation of the slit relative to the nucleus, emissions of atomic hydrogen and oxygen were initially detected. These emissions are spatially localized close to the nucleus and spatially variable with a strong enhancement above the comet's neck at northern latitudes. Weaker emission from atomic carbon and CO were subsequently detected. Results. Analysis of the relative line intensities suggests photoelectron impact dissociation of H2O vapor as the source of the observed H I and O I emissions. The electr...

  11. Investigating the correlations between water coma emissions and active regions in comet 67P/ Churyumov-Gerasimenko

    Science.gov (United States)

    Migliorini, Alessandra; Filacchione, Gianrico; Capaccioni, Fabrizio; Piccioni, Giuseppe; Bockelee-Morvan, Dominique; Érard, Stéphane; Leyrat, Cedric; Combi, Michael R.; Fougere, Nicolas; Rinaldi, Giovanna; VIRTIS Team

    2016-10-01

    Vibrational emission lines of H2O and CO2 at 2.67 and 4.27 μm, respectively, were identified by the VIRTIS spectrometer (Bockelée-Morvan et al., 2015; Migliorini et al., 2016; Fink et al., 2016) and mapped from the surface up to about 10 km altitude with a spatial resolution on the order of tens of meters per pixel (Migliorini et al., 2016).Data acquired in April 2015 with the VIRTIS spectrometer on board the Rosetta mission, provided information on the possible correlation between the H2O emission in the inner coma and the exposed water deposits detected in the Hapi region on the 67P/Churyumov-Gerasimenko surface (Migliorini et al., 2106; De Sanctis et al., 2015). Further bright spots attributed to exposed water ice have been identified in other regions by OSIRIS at visible wavelengths (Pommerol, et al., 2015) and confirmed in the infrared by VIRTIS-M in the Imothep region (Filacchione et al., 2016). The small dimensions of these icy spots - approximately 100x100 m (Filacchione et al., 2016) - and the relatively small amount of water ice (about 5%) make uncertain the correlation with the strong emissions in the coma.However, VIRTIS data show that the distribution of jet-like emissions seems to follow the distribution of cliffs and exposed areas identified in the North hemisphere with OSIRIS camera (Vincent et al., 2015). These areas are mainly concentrated in correspondence of comet's rough terrains, while a lack of active regions is observed in the comet's neck. Nevertheless, strong H2O emission is observed above the neck with VIRTIS. This might be a consequence of gas jets that are originated in the surrounding of the neck but converging towards the neck itself. This gaseous activity is the main driver of the dust upwelling (Migliorini et al, 2016; Rinaldi et al., in preparation)In this paper, we investigate the relationship between H2O vapour observed with VIRTIS within 5 km from the 67P/C-G nucleus and the exposed regions identified by OSIRIS on the surface

  12. Probing the origin of giant radio haloes through radio and γ-ray data: the case of the Coma cluster

    Science.gov (United States)

    Brunetti, G.; Blasi, P.; Reimer, O.; Rudnick, L.; Bonafede, A.; Brown, S.

    2012-10-01

    We combine for the first time all available information about the spectral shape and morphology of the radio halo of the Coma cluster with the recent γ-ray upper limits obtained by the Fermi-Large Area Telescope (LAT) and with the magnetic field strength derived from Faraday rotation measures. We explore the possibility that the radio emission is due to synchrotron emission of secondary electrons. First, we investigate the case of pure secondary models that are merely based on the mechanism of continuous injection of secondary electrons via proton-proton collisions in the intracluster medium. We use the observed spatial distribution of the halo's radio brightness to constrain the amount of cosmic ray protons and their spatial distribution in the cluster that are required by the model. Under the canonical assumption that the spectrum of cosmic rays is a power law in momentum and that the spectrum of secondaries is stationary, we find that the combination of the steep spectrum of cosmic ray protons necessary to explain the spectrum of the halo and the very broad spatial distribution (and large energy density) of cosmic rays result in a γ-ray emission in excess of present limits, unless the cluster magnetic field is relatively large. However, this large magnetic field required to not violate present γ-ray limits appears inconsistent with that derived from recent Faraday rotation measures. Secondly, we investigate more complex models in which the cosmic rays confined diffusively in the Coma cluster and their secondary electrons are all reaccelerated by magnetohydrodynamics turbulence. We show that under these conditions it is possible to explain the radio spectrum and morphology of the radio halo and to predict γ-ray fluxes in agreement with the Fermi-LAT upper limits without tension with present constraints on the cluster magnetic field. Reacceleration of secondary particles also requires a very broad cosmic ray spatial profile, much flatter than that of the

  13. THE INNER COMA OF COMET C/2012 S1 (ISON) AT 0.53 AU AND 0.35 AU FROM THE SUN

    Energy Technology Data Exchange (ETDEWEB)

    Bonev, Boncho P.; Villanueva, Geronimo L.; Paganini, Lucas [Department of Physics, Catholic University of America, Washington, DC 20061 (United States); DiSanti, Michal A.; Gibb, Erika L.; Mumma, Michael J., E-mail: bonev@cua.edu [Goddard Center For Astrobiology, NASA GSFC, Mail Stop 690, Greenbelt, MD 20771 (United States)

    2014-11-20

    Using long-slit spectroscopy at the NASA Infrared Telescope Facility, we extracted H{sub 2}O production rates and spatial profiles of gas rotational temperature and molecular column abundance in comet C/2012 S1 ISON, observed at heliocentric distances of 0.53 and 0.35 AU. These measurements uniquely probed the physical environment in the inner collisional coma of this comet during its first (and last) approach to the Sun since being emplaced in the Oort Cloud some 4.5 billion years ago. Our observations revealed a comet evolving on various timescales, both over hours and days. At 0.35 AU, ISON showed a considerable decrease in water production rate in less than 2 hr, likely declining from a major outburst. Our measured temperature spatial distributions reflect the competition between the processes that cause heating and cooling in the coma, and also provide insight about the prevalent mechanism(s) of releasing gas-phase H{sub 2}O. The observed temperatures suggest that the comet was likely ejecting icy material continuously, which sublimated in the coma and heated the ambient gas, augmenting fast H-atoms produced by H{sub 2}O photolysis. ISON adds to the very limited sample of comets for which spatial-spectral studies of water temperatures have been conducted. These studies are now feasible and can be extended to comets having a variety of gas production rates. Continued synergy of such observations with both space missions like Rosetta and with physical models is strongly encouraged in order to gain a deeper understanding of the processes in the inner collisional zone of the cometary coma.

  14. In-hospital mortality and the Glasgow Coma Scale in the first 72 hours after traumatic brain injury Escala de Coma de Glasgow en las primeras 72 horas postrauma encefalocraneano y mortalidad hospitalaria Escala de Coma de Glasgow nas primeiras 72 horas após trauma cranioencefálico e mortalidade hospitalar

    Directory of Open Access Journals (Sweden)

    Cristina Helena Costanti Settervall

    2011-12-01

    Full Text Available This study verifies and compares the performance of three different scores obtained in the Glasgow Coma Scale (GCS in the first 72 hours post trauma in predicting in-hospital mortality. The studied scores included those obtained after initial care was provided at the hospital, and the worst and best scores obtained in the scale in the first 72 hours post trauma. The scale’s predictive ability was assessed by the Receiver Operator Characteristic (ROC curve. A total of 277 victims with different severity levels of blunt traumatic brain injuries were studied. The performance of the three scores that were analyzed to predict hospital mortality was moderate (0.74 to 0.79 and the areas under the curve did not present statistically significant differences. These findings suggest that any of the three studied scores can be applied in clinical practice to estimate the outcome of victims with blunt traumatic brain injuries, taking into consideration the instrument’s moderate discriminatory power.El estudio tiene como objetivos verificar y comparar el desempeño de puntajes de la Escala de Coma de Glasgow (ECGl observados en las primeras 72 horas postrauma para predecir la mortalidad hospitalaria. Los valores analizados fueron los puntajes obtenidos después de la atención inicial intra-hospitalaria, además de los peores y mejores resultados de la escala en las primeras 72 horas postrauma. La capacidad de predicción de los puntajes de la ECGl para el Estado Vital a la Salida Hospitalaria fue evaluada, utilizando la curva Reciever Operator Characteristic. Fueron estudiadas 277 víctimas, con trauma encefalocraneano contuso de diferentes gravedades. El desempeño de los puntajes de la ECGl para el estado vital a la salida hospitalaria fue moderado (0,74 a 0,79 y las áreas bajo la curva no presentaron diferencia significativa. Los resultados sugieren que cualquiera de los tres valores de la ECGl analizados pueden ser aplicados en la práctica cl

  15. Escala de coma de Glasgow e qualidade de vida pós-trauma cranioencefálico Escala de coma de Glasgow y calidad de vida post-trauma craneoencefálico Glasgow Coma Scale and quality of life after traumatic brain injury

    Directory of Open Access Journals (Sweden)

    Cristina Helena Costanti Settervall

    2012-01-01

    Full Text Available OBJETIVO: Avaliar o desempenho de diferentes escores da Escala de Coma de Glasgow (ECGl observados nas primeiras 72 horas pós trauma perante a qualidade de vida e mudança percebida do estado de saúde, após um ano do evento traumático. MÉTODOS: Estudo de abordagem quantitativa, observacional, longitudinal, descritivo e correlacional com vítimas de trauma cranioencefálico contuso (TCEC avaliadas, diariamente durante a internação hospitalar, e após um ano por meio do Medical Outcome Study 36-item Short Form Health Survey (SF-36. RESULTADOS: sob as curvas Reciever Operator Characteristics dos valores da ECGl referentes à mudança percebida do estado de saúde não apresentaram diferença significativa e variaram de 0,63 a 0,71. Correlação, estatisticamente significante, porém fraca, foi observada entre os escores da ECGl e alguns dos domínios do SF-36. CONCLUSÃO: Verificou-se que os diferentes valores da ECGl apresentaram limitações para que fossem aplicados na prática clínica para estimar as consequências do TCEC a longo prazo.OBJETIVO: Evaluar el desempeño de diferentes escores de la Escala de Coma de Glasgow (ECGl observados en las primeras 72 horas post trauma frente a la calidad de vida y cambio percibido en el estado de salud, después de un año del evento traumático. MÉTODOS: Estudio de abordaje cuantitativo, observacional, longitudinal, descriptivo y correlacional realizado con víctimas de trauma craneoencefálico contuso (TCEC evaluadas, diariamente durante el internamiento hospitalario, y después de un año por medio del Medical Outcome Study 36-item Short Form Health Survey (SF-36. RESULTADOS: bajo las curvas Reciever Operator Characteristics de los valores de la ECGl referentes al cambio percibido en el estado de salud no presentaron diferencia significativa y variaron de 0,63 a 0,71. Correlación, estadísticamente significativa, no obstante débil, fue observada entre los escores de la ECGl y algunos de los

  16. Estratégias de ensino-aprendizagem na enfermagem: análise pela Escala de Coma de Glasgow Estrategias de enseñanza y aprendizaje en enfermería: análisis por la Escala de coma de Glasgow Teaching-learning strategies in nursing: analysis using the Glasgow Coma Scale

    Directory of Open Access Journals (Sweden)

    Ana Beatriz Pinto da Silva Morita

    2009-09-01

    Full Text Available Usando como tema a Escala de Coma de Glasgow (ECGl, este estudo objetivou analisar e verificar a retenção do conhecimento frente às estratégias de ensino-aprendizagem e autoaprendizado oferecidas, e verificar o grau de conhecimento adquirido neste processo e a possível associação entre ser ou não aluno que trabalha na enfermagem. Estudo descritivo de abordagem quantitativa. Participaram 62 alunos regularmente matriculados no primeiro semestre do 4º ano de enfermagem. As estratégias de ensino-aprendizagem utilizadas foram: aula expositiva com diapositivos e videoteipe e texto-base. Dos participantes, 41,9% eram trabalhadores na enfermagem; 61,3% informaram ter cuidado de pacientes com alteração do nível de consciência, com predomínio no grupo em que trabalha. Houve incremento estatisticamente significante no percentual de acerto após a aula expositiva e o videoteipe, não havendo alteração no resultado após o autoaprendizado. Não houve diferença no grau de conhecimento adquirido entre os grupos.Usando como tema la Escala de Coma de Glasgow (ECGl, este estudio objetivó analizar y verificar la retención del conocimiento frente a las estrategias de enseñanza aprendizaje y auto aprendizaje ofrecidas; y, verificar el grado de conocimiento adquirido en ese proceso y la posible asociación entre ser o no alumno que trabaja en enfermería. Estudio descriptivo de abordaje cuantitativo. Participaron 62 alumnos regularmente matriculados en el primer semestre del 4ºaño de enfermería. Las estrategias de enseñanza aprendizaje utilizadas fueron: clase expositiva con diapositivas y videotape y texto base. De los participantes, 41,9% eran trabajadores de enfermería; 61,3% informaron haber cuidado de pacientes con alteración del nivel de conciencia, con predominio en el grupo que trabaja. Hubo un incremento estadísticamente significativo en el porcentaje de aciertos después de la clase expositiva e videotape, no hubo alteración en

  17. Messages from relatives of patients in coma: hope as common element Mensajes de los familiares de pacientes en estado de coma: la esperanza como elemento común Mensagens dos familiares de pacientes em estado de coma: a esperança como elemento comum

    Directory of Open Access Journals (Sweden)

    Ana Cláudia Giesbrecht Puggina

    2008-01-01

    Full Text Available OBJECTIVE: Identifying common meanings in messages from relatives of patients in coma who had been admitted into intensive care units. METHODS: Descriptive study, qualitatively analyzing 30 messages from families of critical state patients. RESULTS: Seven categories emerged: search for spiritual support to overcome difficulties; the necessity of expressing one's feelings; the wish for the patients to return to family life; patients should not worry about external events; family is concerned with reporting the visits, reaffirming that the patient is not alone; concerns about the patient's recovery; memories about daily life and news from home. CONCLUSIONS: Feelings and concerns emerged, along with a universal feeling: hope. This was a part of all categories; hope not only about a cure, but also in adaptation.OBJETIVO: Identificar los significados comunes en los mensajes de los familiares de pacientes en estado de coma internados en una Unidad de Cuidados Intensivos (UCI. MÉTODOS: Se trata de un estudio descriptivo con abordaje cualitativo de análisis de contenido de 30 mensajes de familiares de pacientes en estado crítico. RESULTADOS: Emergieron siete categorías: la búsqueda de apoyo espiritual para superar las dificultades; la necesidad de expresión de los sentimientos; el deseo de que los pacientes retornen a la convivencia familiar; no se preocupen con los acontecimientos externos; preocupación de los familiares para relatar las visitas reafirmando que el paciente no está solo; preocupación en la recuperación de los mismos; recuerdos de la vida cotidiana y noticias de casa. CONCLUSIONES: Emergieron sentimientos y preocupaciones, además de algo universal: la esperanza. Ella permeó prácticamente todas las categorías; esperanza no sólo en la cura, sino también en la adaptación.OBJETIVO: Identificar significados comuns nas mensagens dos familiares de pacientes em estado de coma internados em UTI. MÉTODOS: Estudo descritivo com

  18. Rotation-stimulated structures in the CN and C3 comae of comet 103P/Hartley 2 around the EPOXI encounter

    CERN Document Server

    Waniak, W; Drahus, M; Bonev, T

    2012-01-01

    In late 2010 a Jupiter Family comet 103P/Hartley 2 was a subject of an intensive world-wide investigation. On UT October 20.7 the comet approached the Earth within only 0.12 AU, and on UT November 4.6 it was visited by NASA's EPOXI spacecraft. We joined this international effort and organized an observing campaign. The images of the comet were obtained through narrowband filters using the 2-m telescope of the Rozhen National Astronomical Observatory. They were taken during 4 nights around the moment of the EPOXI encounter. Image processing methods and periodicity analysis techniques were used to reveal transient coma structures and investigate their repeatability and kinematics. We observe shells, arc-, jet- and spiral-like patterns, very similar for the CN and C3 comae. The CN features expanded outwards with the sky-plane projected velocities between 0.1 to 0.3 km/s. A corkscrew structure, observed on November 6, evolved with a much higher velocity of 0.66 km/s. Photometry of the inner coma of CN shows varia...

  19. Immediate, irreversible, posttraumatic coma: a review indicating that bilateral brainstem injury rather than widespread hemispheric damage is essential for its production.

    Science.gov (United States)

    Rosenblum, William I

    2015-03-01

    Traumatic brain injury may result in immediate long-lasting coma. Much attention has been given to predicting this outcome from the initial examination because these predictions can guide future treatment and interactions with the patient's family. Reports of diffuse axonal injury in these cases have ascribed the coma to widespread damage in the deep white matter that disconnects the hemispheres from the ascending arousal system (AAS). However, brainstem lesions are also present in such cases, and the AAS may be interrupted at the brainstem level. This review examines autopsy and imaging literature that assesses the presence, extent, and predictive value of lesions in both sites. The evidence suggests that diffuse injury to the deep white matter is not the usual cause of immediate long-lasting posttraumatic coma. Instead, brainstem lesions in the rostral pons or midbrain are almost always the cause but only if the lesions are bilateral. Moreover, recovery is possible if critical brainstem inputs to the AAS are spared. The precise localization of the latter is subject to ongoing investigation with advanced imaging techniques using magnets of very high magnetic gradients. Limited availability of this equipment plus the need to verify the findings continue to require meticulous autopsy examination.

  20. ON THE ELECTRON-TO-NEUTRAL NUMBER DENSITY RATIO IN THE COMA OF COMET 67P/CHURYUMOV–GERASIMENKO: GUIDING EXPRESSION AND SOURCES FOR DEVIATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Vigren, E.; Eriksson, A. I.; Edberg, N. J. T.; Odelstad, E. [Swedish Institute of Space Physics, Uppsala (Sweden); Galand, M.; Schwartz, S. J., E-mail: erik.vigren@irfu.se [Department of Physics, Imperial College London, London, SW7 2AZ (United Kingdom)

    2015-10-10

    We compute partial photoionization frequencies of H{sub 2}O, CO{sub 2}, and CO, the major molecules in the coma of comet 67P/Churyumov–Gerasimenko, the target comet of the ongoing ESA Rosetta mission. Values are computed from Thermosphere Ionosphere Mesosphere Energy and Dynamics/Solar EUV Experiment solar EUV spectra for 2014 August 1, 2015 March 1, and for perihelion (2015 August, as based on prediction). From the varying total photoionization frequency of H{sub 2}O, as computed from 2014 August 1 to 2015 May 20, we derive a simple analytical expression for the electron-to-neutral number density ratio as a function of cometocentric and heliocentric distance. The underlying model assumes radial movement of the coma constituents and does not account for chemical loss or the presence of electric fields. We discuss various effects/processes that can cause deviations between values from the analytical expression and actual electron-to-neutral number density ratios. The analytical expression is thus not strictly meant as predicting the actual electron-to-neutral number density ratio, but is useful in comparisons with observations as an indicator of processes at play in the cometary coma.

  1. Morphology of galaxies in the Coma cluster region down to M_B=-14.25. I. A catalog of 473 members

    CERN Document Server

    Michard, R

    2008-01-01

    This paper presents morphological type, membership, and U-V color for a sample of galaxies in the Coma cluster direction, complete down to M_B=-15.00 mag and extending down to M_B=-14.25 mag. We have examined 1155 objects from the GMP 1983 catalog on B and V images of the CFH12K camera, and obtained the Hubble type in most cases. Coma cluster membership for 473 galaxies was derived using morphology, apparent size, and surface brightness, and, afterward, redshift. The comparison among morphology- and redshift- memberships and among luminosity functions derived from this morphologically-selected sample, or by using statistical members or spectroscopic members, all show that the morphological membership provided here can be trusted. For the first time, the morphological classification of Coma galaxies reaches magnitudes that are faint enough to observe the whole magnitude range of the giant types, E, S0, and spiral stages. The data presented in this paper makes our sample the richest environment where membership...

  2. Role of Ctf3 and COMA subcomplexes in meiosis: Implication in maintaining Cse4 at the centromere and numeric spindle poles.

    Science.gov (United States)

    Agarwal, Meenakshi; Mehta, Gunjan; Ghosh, Santanu K

    2015-03-01

    During mitosis and meiosis, kinetochore, a conserved multi-protein complex, connects microtubule with the centromere and promotes segregation of the chromosomes. In budding yeast, central kinetochore complex named Ctf19 has been implicated in various functions and is believed to be made up of three biochemically distinct subcomplexes: COMA, Ctf3 and Iml3-Chl4. In this study, we aimed to identify whether Ctf3 and COMA subcomplexes have any unshared function at the kinetochore. Our data suggests that both these subcomplexes may work as a single functional unit without any unique functions, which we tested. Analysis of severity of the defects in the mutants suggests that COMA is epistatic to Ctf3 subcomplex. Interestingly, we noticed that these subcomplexes affect the organization of mitotic and meiotic kinetochores with subtle differences and they promote maintenance of Cse4 at the centromeres specifically during meiosis which is similar to the role of Mis6 (Ctf3 homolog) in fission yeast during mitosis. Interestingly, analysis of ctf3Δ and ctf19Δ mutants revealed a novel role of Ctf19 complex in regulation of SPB cohesion and duplication in meiosis.

  3. 67P/C-G Inner Coma dust properties from 2.2 au inbound to 2.0 au outbound to the Sun

    Science.gov (United States)

    Della Corte, V.; Rotundi, A.; Fulle, M.; Ivanovski, S.; Green, S. F.; Rietmeijer, F. J. M.; Colangeli, L.; Palumbo, P.; Sordini, R.; Ferrari, M.; Accolla, M.; Zakharov, V.; Epifani, E. Mazzotta; Weissman, P.; Gruen, E.; Lopez-Moreno, J. J.; Rodriguez, J.; Bussoletti, E.; Crifo, J. F.; Esposito, F.; Lamy, P. L.; McDonnell, J. A. M.; Mennella, V.; Molina, A.; Morales, R.; Moreno, F.; Palomba, E.; Perrin, J. M.; Rodrigo, R.; Zarnecki, J. C.; Cosi, M.; Giovane, F.; Gustafson, B.; Ortiz, J. L.; Jeronimo, J. M.; Leese, M. R.; Herranz, M.; Liuzzi, V.; Lopez-Jimenez, A. C.

    2016-10-01

    GIADA (Grain Impact Analyzer and Dust Accumulator) on-board the Rosetta space probe is designed to measure the momentum, mass and speed of individual dust particles escaping the nucleus of comet 67P/Churyumov-Gerasimenko (hereafter 67P). From August 2014 to June 2016 Rosetta escorted comet 67P during its journey around the Sun. Here we focus on GIADA data taken between 2015 January and 2016 February which included 67P's perihelion passage. To better understand cometary activity and more specifically the presence of dust structures in cometary comae, we mapped the spatial distribution of dust density in 67P's coma. In this manner we could track the evolution of high density regions of coma dust and their connections with nucleus illumination conditions, namely tracking 67P's seasons. We also studied the link between dust particle speeds and their masses with respect to heliocentric distance, i.e. the level of cometary activity. This allowed us to derive a global and a local correlation of the dust particles' speed distribution with respect to the H2O production rate.

  4. Current emergency therapy. Third edition

    Energy Technology Data Exchange (ETDEWEB)

    Edlich, R.F.; Spyker, D.A.

    1986-01-01

    This book contains over 50 selections. Some of the titles are: Ethanol; Hydrocarbons; Lead; Rubella and Congenital Rubella; Tachycardias; Intracerebral Hemorrhage; Acute Otitis Media; and Diabetic Ketoacidosis and Coma in Adults.

  5. Indian common krait envenomation presenting as fulminant myocarditis and coma: a case report

    Directory of Open Access Journals (Sweden)

    Vijay Kumar Verma

    2014-08-01

    Full Text Available Fulminant myocarditis is an unusual manifestation of cardiotoxicity with severe elapid snake envenoming and is meagrely reported with snake bite due to Indian common krait. We report a 12-year-old boy who was admitted in complete locked-in state and hemodynamic instability after severe neurotoxic snake envenoming by Bungarus caeruleus (Indian common krait. His hospital course was complicated with recurrent episodes of sustained ventricular tachycardia requiring defibrillation; and cardiogenic shock requiring inotropes, vasopressors and intraaortic balloon counterpulsation. Severe heart failure features secondary to fulminant toxic myocarditis persisted even after full neurological recovery requiring prolonged standard medical heart failure therapy. Patient subsequently achieved full clinical recovery and regained normal left ventricular systolic function. We also reviewed the literature on cardiac manifestations, possible mechanisms and treatment of patients with cardiotoxicity due to elapid snake bites. The importance of anticipating severe cardiovascular complications is highlighted to help formulate appropriate therapeutic strategy. [Int J Res Med Sci 2014; 2(4.000: 1713-1717

  6. Neuroprognostication of hypoxic-ischaemic coma in the therapeutic hypothermia era.

    Science.gov (United States)

    Greer, David M; Rosenthal, Eric S; Wu, Ona

    2014-04-01

    Neurological prognostication after cardiac arrest has always been challenging, and has become even more so since the advent of therapeutic hypothermia (TH) in the early 2000s. Studies in this field are prone to substantial biases--most importantly, the self-fulfilling prophecy of early withdrawal of life-sustaining therapies--and physicians must be aware of these limitations when evaluating individual patients. TH mandates sedation and prolongs drug metabolism, and delayed neuronal recovery is possible after cardiac arrest with or without hypothermia treatment; thus, the clinician must allow an adequate observation period to assess for delayed recovery. Exciting advances have been made in clinical evaluation, electrophysiology, chemical biomarkers and neuroimaging, providing insights into the underlying pathophysiological mechanisms of injury, as well as prognosis. Some clinical features, such as pupillary reactivity, continue to provide robust information about prognosis, and EEG patterns, such as reactivity and continuity, seem promising as prognostic indicators. Evoked potential information is likely to remain a reliable prognostic tool in TH-treated patients, whereas traditional serum biomarkers, such as neuron-specific enolase, may be less reliable. Advanced neuroimaging techniques, particularly those utilizing MRI, hold great promise for the future. Clinicians should continue to use all the available tools to provide accurate prognostic advice to patients after cardiac arrest.

  7. Hematoma extradural estudo radiológico comparativo entre pacientes em coma e não comatosos

    Directory of Open Access Journals (Sweden)

    Luis Renato Mello

    1992-09-01

    Full Text Available Considerando o estado neurológico imediatamente antes da operação como a variável miais fidedigna para antecipação do prognóstico dos hematomas extradurais, os autores realizaram estudo radiológico comparativo de 129 pacientes operados por esta patologia. Desta amostra, 78 casos se encontravam em coma (Grupo I e 51 eram não comatosos (Grupo II. No grupo I, os 30 casos investigados pré-operatoriamente com tomografia tiveram 23,3% de mortalidade e 50% de bons resultados; dos 31 casos submetidos a angiografia, 48,3% faleceram e 38,7% tiveram bons resultados; 17 casos foram operados pela radiografia simples de crânio e exame neurológico, com 47% de mortalidade e 35,2% de bons resultados. A presença de fratura de crânio e a densidade tomográfica do hematoma não interferiram nos resultados. A presença de lesão associada intracraniana aumentou a mortalidade e diminuiu a quantidade de bons resultados tanto no Grupo I quanto no Grupo II. A localização frontal do hematoma foi associada a elevada mortalidade (52,6% no grupo comatoso, por estarem todos os pacientes entre 3 a 5 pontos na Escala de Glasgow e seis deles por apresentarem lesões associadas intracranianas únicas ou múltiplas.

  8. Environmental quenching and hierarchical cluster assembly: Evidence from spectroscopic ages of red-sequence galaxies in Coma

    CERN Document Server

    Smith, Russell J; Price, James; Hudson, Michael J; Phillipps, Steven

    2011-01-01

    We explore the variation in stellar population ages for Coma cluster galaxies as a function of projected cluster-centric distance, using a sample of 362 red-sequence galaxies with high signal-to-noise spectroscopy. The sample spans a wide range in luminosity (0.02-4 L*) and extends from the cluster core to near the virial radius. We find a clear distinction in the observed trends of the giant and dwarf galaxies. The ages of red-sequence giants are primarily determined by galaxy mass, with only weak modulation by environment, in the sense that galaxies at larger cluster-centric distance are slightly younger. For red-sequence dwarfs (with mass <10^10 Msun), the roles of mass and environment as predictors of age are reversed: there is little dependence on mass, but strong trends with projected cluster-centric radius are observed. The average age of dwarfs at the 2.5 Mpc limit of our sample is approximately half that of dwarfs near the cluster centre. The gradient in dwarf galaxy ages is a global cluster-centr...

  9. Prebiotic chemicals—amino acid and phosphorus—in the coma of comet 67P/Churyumov-Gerasimenko

    Science.gov (United States)

    Altwegg, Kathrin; Balsiger, Hans; Bar-Nun, Akiva; Berthelier, Jean-Jacques; Bieler, Andre; Bochsler, Peter; Briois, Christelle; Calmonte, Ursina; Combi, Michael R.; Cottin, Hervé; De Keyser, Johan; Dhooghe, Frederik; Fiethe, Bjorn; Fuselier, Stephen A.; Gasc, Sébastien; Gombosi, Tamas I.; Hansen, Kenneth C.; Haessig, Myrtha; Jäckel, Annette; Kopp, Ernest; Korth, Axel; Le Roy, Lena; Mall, Urs; Marty, Bernard; Mousis, Olivier; Owen, Tobias; Rème, Henri; Rubin, Martin; Sémon, Thierry; Tzou, Chia-Yu; Hunter Waite, James; Wurz, Peter

    2016-01-01

    The importance of comets for the origin of life on Earth has been advocated for many decades. Amino acids are key ingredients in chemistry, leading to life as we know it. Many primitive meteorites contain amino acids, and it is generally believed that these are formed by aqueous alterations. In the collector aerogel and foil samples of the Stardust mission after the flyby at comet Wild 2, the simplest form of amino acids, glycine, has been found together with precursor molecules methylamine and ethylamine. Because of contamination issues of the samples, a cometary origin was deduced from the 13C isotopic signature. We report the presence of volatile glycine accompanied by methylamine and ethylamine in the coma of 67P/Churyumov-Gerasimenko measured by the ROSINA (Rosetta Orbiter Spectrometer for Ion and Neutral Analysis) mass spectrometer, confirming the Stardust results. Together with the detection of phosphorus and a multitude of organic molecules, this result demonstrates that comets could have played a crucial role in the emergence of life on Earth. PMID:27386550

  10. Prebiotic chemicals-amino acid and phosphorus-in the coma of comet 67P/Churyumov-Gerasimenko.

    Science.gov (United States)

    Altwegg, Kathrin; Balsiger, Hans; Bar-Nun, Akiva; Berthelier, Jean-Jacques; Bieler, Andre; Bochsler, Peter; Briois, Christelle; Calmonte, Ursina; Combi, Michael R; Cottin, Hervé; De Keyser, Johan; Dhooghe, Frederik; Fiethe, Bjorn; Fuselier, Stephen A; Gasc, Sébastien; Gombosi, Tamas I; Hansen, Kenneth C; Haessig, Myrtha; Jäckel, Annette; Kopp, Ernest; Korth, Axel; Le Roy, Lena; Mall, Urs; Marty, Bernard; Mousis, Olivier; Owen, Tobias; Rème, Henri; Rubin, Martin; Sémon, Thierry; Tzou, Chia-Yu; Hunter Waite, James; Wurz, Peter

    2016-05-01

    The importance of comets for the origin of life on Earth has been advocated for many decades. Amino acids are key ingredients in chemistry, leading to life as we know it. Many primitive meteorites contain amino acids, and it is generally believed that these are formed by aqueous alterations. In the collector aerogel and foil samples of the Stardust mission after the flyby at comet Wild 2, the simplest form of amino acids, glycine, has been found together with precursor molecules methylamine and ethylamine. Because of contamination issues of the samples, a cometary origin was deduced from the (13)C isotopic signature. We report the presence of volatile glycine accompanied by methylamine and ethylamine in the coma of 67P/Churyumov-Gerasimenko measured by the ROSINA (Rosetta Orbiter Spectrometer for Ion and Neutral Analysis) mass spectrometer, confirming the Stardust results. Together with the detection of phosphorus and a multitude of organic molecules, this result demonstrates that comets could have played a crucial role in the emergence of life on Earth.

  11. Halpha3: an Halpha imaging survey of HI selected galaxies from ALFALFA. V: The Coma Supercluster survey completion

    CERN Document Server

    Gavazzi, Giuseppe; Viscardi, Elisa; Fossati, Matteo; Savorgnan, Giulia; Fumagalli, Michele; Gutierrez, Leonel; Toledo, Hector Hernandez; Boselli, Alessandro; Giovanelli, Riccardo; Haynes, Martha P

    2015-01-01

    Neutral hydrogen represents the major observable baryonic constituent of galaxies that fuels the formation of stars through the transformation in molecular hydrogen. The emission of the hydrogen recombination line Halpha is the most direct tracer of the process that transforms gas (fuel) into stars. We continue to present Halpha3 (acronym for Halpha-alpha-alpha), an extensive Halpha+[NII] narrow-band imaging campaign of galaxies selected from the HI Arecibo Legacy Fast ALFA Survey (ALFALFA), using the instrumentation available at the San Pedro Martir observatory (Mexico). In only four years since 2011 we were able to complete in 48 nights the Halpha imaging observations of 724 galaxies in the region of the Coma supercluster 10^h < R.A. <16^h; 24^o < Dec. <28^o and 3900

  12. Effect of erythropoietin on Glasgow Coma Scale and Glasgow Outcome Sale in patient with diffuse axonal injury

    Directory of Open Access Journals (Sweden)

    Saeid Abrishamkar

    2012-01-01

    Full Text Available Background: Erythropoietin (EPO as a major stimulator of red blood cell (RBC production play a key role on brain protection and have a caring effect on neurons from hypoxic or traumatic injury. The objective of this trial was to study the safety and efficacy of recombinant human EPO (rhEPO on level of consciousness and other outcomes in patient with post traumatic diffuse axonal injury (PTDAI. Methods: In a controlled double-blind randomized clinical trial, 54 patients aged 20-47 years were randomly allocated to 2 groups. Subjects in intervention group (n = 27 received 2000U open-label rhEPO (Erythropoietin-ί; Roche, Gren-zach-Wyhlen, Germany subcutaneously for six doses in two weeks (on days: 2, 4, 6, 8 and 10. The efficacies of the intervention were evaluated by GCS (Glasgow Coma Scale and GOS (Glasgow Outcome Scale. Results: The patients that were treated by rhEPO improved earlier with the difference between the treatment groups occurring on the day 10 (score differences of 9.6 for GCS and 1.9 for GOS. The better course of the rhEPO-treated patients continued throughout the remaining study period. The hematocrit and red blood cell counts did not increase to levels exceeding the normal range in rhEPO patients. Conclusions: Intravenous EPO was well tolerated in diffuse axonal injury and was associated with an improvement in patients′ outcome in 2 weeks.

  13. Dissecting the Red Sequence: The Bulge and Disc Colours of Early-Type Galaxies in the Coma Cluster

    CERN Document Server

    Head, Jacob T C G; Hudson, Micheal J; Smith, Russel J

    2014-01-01

    We explore the internal structure of red sequence galaxies in the Coma cluster across a wide range of luminosities ($-17>M_g>-22$) and cluster-centric radii ($0

  14. The heliocentric variation of the outgassing rate and molecular abundances in the coma of 67P as seen by MIRO

    Science.gov (United States)

    Biver, Nicolas; Hofstadter, Mark; von Allmen, Paul; Bockelee-Morvan, Dominique; Choukroun, Mathieu; Gulkis, Samuel; Lee, Seungwon; Schloerb, F. Peter; Rezac, Ladislav; Leyrat, Cedric; Davidsson, Bjorn; Ip, Wing-Huen; MIRO team

    2016-10-01

    During the two years around the Aug. 2015 perihelion, the MIRO instrument on board the Rosetta spacecraft has been regularly mapping the emission of 8 molecular lines around 560 GHz (H2O and its isotopes, CO, NH3 and CH3OH) in the inner coma of comet 67P/Churyumov-Gerasimenko. We have used those observations to estimate the mean outgassing rates as a function of time in 2014-2016 and heliocentric distance (Rh=1.2-4 AU). The peak outgassing rate of water (~1028 molec./s), based on maps of H218O was reached slightly after perihelion. We have also measured the evolution of the abundances relative to water of CO, CH3OH and NH3. The abundances of CH3OH and CO significantly increased around and after perihelion time when most of the outgassing was coming from the illuminated southern pole. We have also retrieved the 3-D outgassing patterns, which enabled us to track the location of the bulk of outgassing for each molecule.

  15. Comparison between Navier-Stokes and Direct Monte-Carlo Simulations of the Circumnuclear Coma. I. Homogeneous, Spherical Source

    Science.gov (United States)

    Crifo, J. F.; Lukianov, G. A.; Rodionov, A. V.; Khanlarov, G. O.; Zakharov, V. V.

    2002-03-01

    The structure of the near-nucleus H 2O atmosphere formed by sublimation under solar heating of a hypothetical large dusty ice sphere is computed (1) by the direct simulation Monte-Carlo method (DSMC) and (2) by solving Navier-Stokes equations (NSE) combined with a locally plane-parallel solution of the collisional Boltzmann equation for the nonequilibrium near-surface Knudsen layer. For Hale-Bopp-like comets, perfect agreement is obtained between the two methods on the day and night sides. This excellent agreement is maintained on the near-nucleus dayside for less productive comets, even down to production rates as low as those expected for Comet P/Wirtanen near 3 AU. It provides a direct validation of the gasdynamic simulations performed in support of the ESA Rosetta mission lander descent optimization studies (Crifo et al. 2001) and also confirms the similarity between the dayside coma and underexpanded axially symmetric free jets pointed out in Crifo (1986). On the nightside, moderate to high discrepancies appear between the two solutions as the production rate decreases, revealing the limits of the NSE method. The limits of the present study are delineated, and directions for future investigations are indicated.

  16. Changes in the physical environment of the inner coma of 67P/Churyumov-Gerasimenko with decreasing heliocentric distance

    CERN Document Server

    Bodewits, D; A'Hearn, M F; La Forgia, F; Giquel, A; Kovacs, G; Knollenberg, J; Lazzarin, M; Lin, Z -Y; Shi, X; Snodgrass, C; Tubiana, C; Sierks, H; Barbieri, C; Lamy, P M; Rodrigo, R; Koschny, D; Rickman, H; Keller, H U; Barucci, M A; Bertaux, J -L; Bertini, I; Boudreault, S; Cremonese, G; DaDeppo, V; Davidsson, B; Debei, S; De Cecco, M; Fornasier, S; Fulle, M; Groussin, O; Gutierrez, P J; Guettler, C; Hviid, S F; Ip, W -H; Jorda, L; Kramm, J -R; Kuehrt, E; Kueppers, M; Lopez-Moreno, J J; Marzari, F; Naletto, G; Oklay, N; Thomas, N; Toth, I; Vincent, J -B

    2016-01-01

    The Wide Angle Camera of the OSIRIS instrument on board the Rosetta spacecraft is equipped with several narrowband filters that are centered on the emission lines and bands of various fragment species. These are used to determine the evolution of the production and spatial distribution of the gas in the inner coma of comet 67P with time and heliocentric distance, here between 2.6 - 1.3 AU pre-perihelion. Our observations indicate that the emission observed in the OH, OI, CN, NH, and NH2 filters is mostly produced by dissociative electron impact excitation of different parent species. We conclude that CO2 rather than H2O is a significant source of the [OI] 630 nm emission. A strong plume-like feature observed in the in CN and [OI] filters is present throughout our observations. This plume is not present in OH emission and indicates a local enhancement of the CO2/H2O ratio by as much as a factor of 3. We observed a sudden decrease in intensity levels after March 2015, which we attribute to decreased electron te...

  17. Prebiotic chemicals--amino acid and phosphorus--in the coma of comet 67P/Churyumov-Gerasimenko

    Science.gov (United States)

    Altwegg, K.; Balsiger, H.; Bar-Nun, A.; Berthelier, J.-J.; Bieler, A.; Bochsler, P.; Briois, C.; Calmonte, U.; Combi, M. R.; Cottin, H.; De Keyser, J.; Dhooghe, F.; Fiethe, B.; Fuselier, S. A.; Gasc, S.; Gombosi, T. I.; Hansen, K. C.; Haessig, M.; Ja ckel, A.; Kopp, E.; Korth, A.; Le Roy, L.; Mall, U.; Marty, B.; Mousis, O.; Owen, T.; Reme, H.; Rubin, M.; Semon, T.; Tzou, C.-Y.; Waite, J. Hunter; Wurz, P.

    2016-05-01

    The importance of comets for the origin of life on Earth has been advocated for many decades. Amino acids are key ingredients in chemistry, leading to life as we know it. Many primitive meteorites contain amino acids, and it is generally believed that these are formed by aqueous alterations. In the collector aerogel and foil samples of the Stardust mission after the flyby at comet Wild 2, the simplest form of amino acids, glycine, has been found together with precursor molecules methylamine and ethylamine. Because of contamination issues of the samples, a cometary origin was deduced from the 13C isotopic signature. We report the presence of volatile glycine accompanied by methylamine and ethylamine in the coma of 67P/Churyumov-Gerasimenko measured by the ROSINA (Rosetta Orbiter Spectrometer for Ion and Neutral Analysis) mass spectrometer, confirming the Stardust results. Together with the detection of phosphorus and a multitude of organic molecules, this result demonstrates that comets could have played a crucial role in the emergence of life on Earth.

  18. The Highly Unusual Outgassing of Comet 103P/Hartley 2 from Narrowband Photometry and Imaging of the Coma

    CERN Document Server

    Knight, Matthew M

    2012-01-01

    We report on photometry and imaging of Comet 103P/Hartley 2 obtained at Lowell Observatory from 1991 through 2011. We acquired photoelectric photometry on two nights in 1991, four nights in 1997/98, and 13 nights in 2010/11. We observed a strong secular decrease in water and all other observed species production in 2010/11 from the 1991 and 1997/98 levels. We see evidence for a strong asymmetry with respect to perihelion in the production rates of our usual bandpasses, with peak production occurring ~10 days post-perihelion and production rates considerably higher post-perihelion. The composition was "typical", in agreement with the findings of other investigators. We obtained imaging on 39 nights from 2010 July until 2011 January. We find that, after accounting for their varying parentage and lifetimes, the C2 and C3 coma morphology resemble the CN morphology we reported previously. These species exhibited an hourglass shape in October and November, and the morphology changed with rotation and evolved over t...

  19. Technology-aided programs for post-coma patients emerged from or in a minimally conscious state

    Directory of Open Access Journals (Sweden)

    Giulio E. Lancioni

    2014-12-01

    Full Text Available Post-coma persons in a minimally conscious state (MCS or emerged/emerging from such state (E-MCS, who are affected by extensive motor impairment and lack of speech, may develop an active role and interact with their environment with the help of technology-aided intervention programs. Although a number of studies have been conducted in this area during the last few years, new evidence about the efficacy of those programs is warranted. These three studies were an effort in that direction. Study I assessed a technology-aided program to enable six MCS participants to access preferred environmental stimulation independently. Studies II and III assessed technology-aided programs to enable six E-MCS participants to make choices. In Study II, three of those participants were led to choose among leisure and social stimuli, and caregiver interventions automatically presented to them. In Study III, the remaining three participants were led to choose (a among general stimulus/intervention options (e.g., songs, video-recordings of family members, and caregiver interventions and then (b among variants of those options. The results of all three studies were largely positive with substantial increases of independent stimulation access for the participants of Study I and independent choice behavior for the participants of Studies II and III. The results were analyzed in relation to previous data and in terms of their implications for daily contexts working with MCS and E-MCS persons affected by multiple disabilities.

  20. Determination of a pressure discontinuity at the position of the Coma relic from Planck Sunyaev-Zeldovich effect data

    CERN Document Server

    Erler, Jens; Trasatti, Monica; Klein, Ulrich; Bertoldi, Frank

    2014-01-01

    Radio relics are Mpc-scale diffuse synchrotron sources found in galaxy cluster outskirts. They are believed to be associated with large-scale shocks propagating through the intra-cluster medium, although the connection between radio relics and the cluster merger shocks is not yet proven conclusively. We present a first tentative detection of a pressure jump in the well-known relic of the Coma cluster through Sunyaev-Zel'dovich (SZ) effect imaging. The SZ data is extracted from the first public all-sky data release of Planck and we use high-frequency radio data at 2.3 GHz to constrain the shock-front geometry. The SZ data provides evidence for a pressure discontinuity, consistent with the relic position, without requiring any additional prior on the shock-front location. The derived Mach number M = 2.9 (+0.8/-0.6) is consistent with X-ray and radio results. A high-pressure "filament" without any pressure discontinuity is disfavoured by X-ray measurements and a "sub-cluster" model based on the infalling group N...

  1. Probing the origin of giant radio halos through radio and gamma-ray data : the case of the Coma cluster

    CERN Document Server

    Brunetti, G; Reimer, O; Rudnick, L; Bonafede, A; Brown, S

    2012-01-01

    We combine all available information about the spectral shape and morphology of the radio halo of the Coma cluster with the gamma-ray upper limits obtained by the Fermi-LAT and with the magnetic field strength derived from Faraday rotation measures (RM). We explore the possibility that the radio halo is due to synchrotron emission of secondary electrons generated via p-p collisions in the intra-cluster-medium (ICM). First we investigate the case of pure secondary models. We use the observed spatial distribution of the halo's radio brightness to constrain the amount of cosmic rays (CRs) and their spatial distribution in the cluster that are required by the model. Under the canonical assumption that the spectrum of CRs is a power-law in momentum and that the spectrum of secondaries is stationary, we find that the combination of the steep spectrum of CRs necessary to explain the spectrum of the halo and their very broad spatial distribution (and large energy density) result in a gamma-ray emission in excess of p...

  2. Electroencephalography reactivity for prognostication of post-anoxic coma after cardiopulmonary resuscitation: A comparison of quantitative analysis and visual analysis.

    Science.gov (United States)

    Liu, Gang; Su, Yingying; Jiang, Mengdi; Chen, Weibi; Zhang, Yan; Zhang, Yunzhou; Gao, Daiquan

    2016-07-28

    Electroencephalogram reactivity (EEG-R) is a positive predictive factor for assessing outcomes in comatose patients. Most studies assess the prognostic value of EEG-R utilizing visual analysis; however, this method is prone to subjectivity. We sought to categorize EEG-R with a quantitative approach. We retrospectively studied consecutive comatose patients who had an EEG-R recording performed 1-3 days after cardiopulmonary resuscitation (CPR) or during normothermia after therapeutic hypothermia. EEG-R was assessed via visual analysis and quantitative analysis separately. Clinical outcomes were followed-up at 3-month and dichotomized as recovery of awareness or no recovery of awareness. A total of 96 patients met the inclusion criteria, and 38 (40%) patients recovered awareness at 3-month followed-up. Of 27 patients with EEG-R measured with visual analysis, 22 patients recovered awareness; and of the 69 patients who did not demonstrated EEG-R, 16 patients recovered awareness. The sensitivity and specificity of visually measured EEG-R were 58% and 91%, respectively. The area under the receiver operating characteristic curve for the quantitative analysis was 0.92 (95% confidence interval, 0.87-0.97), with the best cut-off value of 0.10. EEG-R through quantitative analysis might be a good method in predicting the recovery of awareness in patients with post-anoxic coma after CPR.

  3. Extremely organic-rich coma of comet C/2010 G2 (Hill) during its outburst in 2012

    Energy Technology Data Exchange (ETDEWEB)

    Kawakita, Hideyo; Kobayashi, Hitomi [Koyama Astronomical Observatory, Kyoto Sangyo University, Motoyama, Kamitamo, Kita, Kyoto 603-8555 (Japan); Russo, Neil Dello; Vervack, Ron Jr.; Weaver, Harold A. [The Johns Hopkins University Applied Physics Laboratory, Laurel, MD 20723-6099 (United States); DiSanti, Mike A. [Goddard Center for Astrobiology, NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Opitom, Cyrielle; Jehin, Emmanuel; Manfroid, Jean; Gillon, Michael [F. R. S.-FNRS, Institut d' Astrophysique et de Géophysique, Université de Liège, Allée du 6 août 17, B-4000 Liège (Belgium); Cochran, Anita L. [McDonald Observatory, 1 University Station C1402, Austin, TX 78712-0259 (United States); Harris, Walter M. [Department of Applied Sciences, University of California, One Shields Avenue, Davis, CA 95616 (United States); Bockelée-Morvan, Dominique; Biver, Nicolas; Crovisier, Jacques [LESIA, Observatoire de Paris, CNRS, UPMC, Université Paris-Diderot, 5 Place Jules Janssen, F-92195 Meudon (France); McKay, Adam J., E-mail: kawakthd@cc.kyoto-su.ac.jp [New Mexico State University, Las Cruces, NM 88001 (United States)

    2014-06-20

    We performed high-dispersion near-infrared spectroscopic observations of comet C/2010 G2 (Hill) at 2.5 AU from the Sun using NIRSPEC (R ≈ 25,000) at the Keck II Telescope on UT 2012 January 9 and 10, about a week after an outburst had occurred. Over the two nights of our observations, prominent emission lines of CH{sub 4} and C{sub 2}H{sub 6}, along with weaker emission lines of H{sub 2}O, HCN, CH{sub 3}OH, and CO were detected. The gas production rate of CO was comparable to that of H{sub 2}O during the outburst. The mixing ratios of CO, HCN, CH{sub 4}, C{sub 2}H{sub 6}, and CH{sub 3}OH with respect to H{sub 2}O were higher than those for normal comets by a factor of five or more. The enrichment of CO and CH{sub 4} in comet Hill suggests that the sublimation of these hypervolatiles sustained the outburst of the comet. Some fraction of water in the inner coma might exist as icy grains that were likely ejected from nucleus by the sublimation of hypervolatiles. Mixing ratios of volatiles in comet Hill are indicative of the interstellar heritage without significant alteration in the solar nebula.

  4. 酒精性低血糖昏迷3例并文献复习%Alcoholic hypoglycemic coma three cases and literature review

    Institute of Scientific and Technical Information of China (English)

    梁学梅

    2013-01-01

    Objective To improve the clinical doctors knowledge of alcoholic hypoglycemic coma. Methods analysis the clinical characteristics of 3 patients with alcoholic hypog-lycemic coma, diagnosis, treatment and clinical prognosis. Results 3 cases of male patients, the average age of 57.3 years. Because of disturbance of consciousness, introduced the first big sweat, heart palpitations, hand shaking, then occurs after the symptom such as loss of consciousness, the monitoring found that different degrees of lower blood glucose, blood sugar given intravenous glucose consciousness turned clear, after treatment without leave sequela. Conclusion although alcoholism is a common clinical emergency, the emergency department, severe cases can be life-threatening should be treated timely diagnosis and active treatment. But alcoholic coma and hypoglycemic coma very similar clinical manifestations, it is easy to confuse, need strict distinction. For patients with sudden coma after drinking, besides considering cerebrovascular disease and alcohol poisoning should be timely measuring blood sugar, in order to avoid misdiagnosis delayed treatment.%目的:提高临床医生对酒精性低血糖昏迷的认识。方法分析3例酒精性低血糖昏迷患者的临床特点,诊断思路,治疗过程以及临床预后。结果3个病例均为男性患者,平均年龄57.3岁。均因意识障碍就诊,首先出现了大汗,心悸,手抖等症状后继而出现意识丧失,经监测血糖发现不同程度的血糖降低,给予静脉补充葡萄糖治疗后意识转清,未留后遗症。结论酒精中毒虽然是急诊科常见的临床急症,严重者可以危及生命,应该及时的诊断发生和积极处理治疗。但是酒精中毒性昏迷和低血糖性昏迷临床表现非常相似,很容易混淆,需要严格区分。对于饮酒后突发昏迷患者,除考虑脑血管症及酒精中毒外应及时测血糖,以免误诊延误治疗。

  5. Comet C2012 S1 (ISON)s Carbon-rich and Micron-size-dominated Coma Dust

    Science.gov (United States)

    Wooden, D.; De Buizer, J.; Kelley, M.; Sitko, M.; Woodward, C.; Harker, D.; Reach, W.; Russell, R.; Kim, D.; Yanamadra-Fisher, P.; Lisse, C.; de Pater, I.; Gehrz, R.; Kolokolova, L.

    2014-01-01

    Comet C/2012 S1 (ISON) was unique in that it was a dynamically new comet derived from the Nearly Isotropic Oort cloud reservoir of comets with a sun-grazing orbit. We present thermal models for comet ISON (rh approx.1.15 AU, 2013-Oct-25 11:30 UT) that reveal comet ISON's dust was carbon-rich and dominated by a narrow size distribution dominated by approx. micron-sized grains. We constrained the models by our SOFIA FORCAST photometry at 11.1, 19.7 and 31.5 microns and by a silicate feature strength of approx.1.1 and an 8-13microns continuum greybody color temperature of approx. 275-280 K (using Tbb ? r-0.5 h and Tbb approx. 260-265 K from Subaru COMICS, 2013-Oct-19 UT)[1,2]. N-band spectra of comet ISON with the BASS instrument on the NASA IRTF (2013-Nov-11-12 UT) show a silicate feature strength of approx. 1.1 and an 11.2microns forsterite peak.[3] Our thermal models yield constraints the dust composition as well as grain size distribution parameters: slope, peak grain size, porosity. Specifically, ISON's dust has a low silicate-to- amorphous carbon ratio (approx. 1:9), and the coma size distribution has a steep slope (N4.5) such that the coma is dominated by micron-sized, moderately porous, carbon-rich dust grains. The N-band continuum color temperature implies submicronto micron-size grains and the steep fall off of the SOFIA far-IR photometry requires the size distribution to have fewer relative numbers of larger and cooler grains compared to smaller and hotter grains. A proxy for the dust production rate is f? approx.1500 cm, akin to Af?. ISON has a moderate-to-low dust-to-gas ratio. Comet ISON's dust grain size distribution does not appear similar to the few well-studied long-period Nearly Isotropic Comets (NICs), namely C/1995 O1 (Hale-Bopp) and C/2001 Q4 (NEAT) that had smaller and/or more highly porous grains and larger sizes, or C/2007 N4 (Lulin) and C/2006 P1 (McNaught) that had large and/or compact grains. Radial transport to comet-forming disk distances

  6. Acceleration of individual, decimetre-sized aggregates in the lower coma of comet 67P/Churyumov-Gerasimenko

    Science.gov (United States)

    Agarwal, Jessica; A'Hearn, M. F.; Vincent, J.-B.; Güttler, C.; Höfner, S.; Sierks, H.; Tubiana, C.; Barbieri, C.; Lamy, P. L.; Rodrigo, R.; Koschny, D.; Rickman, H.; Barucci, M. A.; Bertaux, J.-L.; Bertini, I.; Boudreault, S.; Cremonese, G.; Da Deppo, V.; Davidsson, B.; Debei, S.; De Cecco, M.; Deller, J.; Fornasier, S.; Fulle, M.; Gicquel, A.; Groussin, O.; Gutiérrez, P. J.; Hofmann, M.; Hviid, S. F.; Ip, W.-H.; Jorda, L.; Keller, H. U.; Knollenberg, J.; Kramm, J.-R.; Kührt, E.; Küppers, M.; Lara, L. M.; Lazzarin, M.; Lopez Moreno, J. J.; Marzari, F.; Naletto, G.; Oklay, N.; Shi, X.; Thomas, N.

    2016-11-01

    We present observations of decimetre-sized, likely ice-containing aggregates ejected from a confined region on the surface of comet 67P/Churyumov-Gerasimenko. The images were obtained with the narrow angle camera of the Optical, Spectroscopic, and Infrared Remote Imaging System on board the Rosetta spacecraft in 2016 January when the comet was at 2 au from the Sun outbound from perihelion. We measure the acceleration of individual aggregates through a 2 h image series. Approximately 50 per cent of the aggregates are accelerated away from the nucleus, and 50 per cent towards it, and likewise towards either horizontal direction. The accelerations are up to one order of magnitude stronger than local gravity, and are most simply explained by the combined effect of gas drag accelerating all aggregates upwards, and the recoil force from asymmetric outgassing, either from rotating aggregates with randomly oriented spin axes and sufficient thermal inertia to shift the temperature maximum away from an aggregate's subsolar region, or from aggregates with variable ice content. At least 10 per cent of the aggregates will escape the gravity field of the nucleus and feed the comet's debris trail, while others may fall back to the surface and contribute to the deposits covering parts of the Northern hemisphere. The rocket force plays a crucial role in pushing these aggregates back towards the surface. Our observations show the future back fall material in the process of ejection, and provide the first direct measurement of the acceleration of aggregates in the innermost coma (<2 km) of a comet, where gas drag is still significant.

  7. Life-threatening coma and full-thickness sunburn in a patient treated with transdermal fentanyl patches: a case report

    Directory of Open Access Journals (Sweden)

    Sindali Katia

    2012-07-01

    Full Text Available Abstract Introduction Fentanyl transdermal patches have been widely used in the treatment of chronic pain and in palliative care settings since 1991 in cases where prolonged opioid use is often necessary. Transdermal drug delivery is deemed safe and effective with the advantages of delivering a steady dose of the drug and improving patient compliance due to its ease of use. However, intentional and unintentional misuse and overdose using transdermal opioid patches has been widely reported in the literature. Case presentation We describe the case of a 77-year-old Caucasian woman who developed severe opioid toxicity while sun tanning, likely due to altered fentanyl transdermal patch function in a heated environment. As a result of prolonged sun exposure due to an opioid-induced coma she then sustained hyperthermia and severe burns to her abdomen and lower limbs. This inadvertent fentanyl overdose necessitated initial treatment in intensive care and follow on care in a specialist burn unit. Conclusion Patients who are using fentanyl patches and their relatives should be educated about how to use the patch safely. Healthcare practitioners should warn patients about the possibility of overdosing on transdermally delivered drugs if used incorrectly. They should avoid strenuous activities and external heat sources such as warming blankets, hot water bottles, saunas, hot tubs or sunbathing and should seek medical attention if they develop a fever. Additionally, any burns sustained in the context of altered consciousness levels such as in this case with opioid overdose should raise suspicion about a potential deeper burn injury than is usually observed.

  8. Sweat Therapy.

    Science.gov (United States)

    Colmant, Stephen A.; Merta, Rod J.

    2000-01-01

    A study combined group sweating and group counseling. Four adolescent boys with disruptive behavior disorders participated in 12 sweat therapy sessions. They reported the sessions useful for sharing personal concerns and receiving assistance with problem solving. Three boys showed improvement in self-esteem. Advantages of sweat therapy over other…

  9. Hyperbaric oxygen therapy for the treatment of traumatic brain injury: a meta-analysis.

    Science.gov (United States)

    Wang, Fei; Wang, Yong; Sun, Tao; Yu, Hua-Lin

    2016-05-01

    Compelling evidence suggests the advantage of hyperbaric oxygen therapy (HBOT) in traumatic brain injury. The present meta-analysis evaluated the outcomes of HBOT in patients with traumatic brain injury (TBI). Prospective studies comparing hyperbaric oxygen therapy vs. control in patients with mild (GCS 13-15) to severe (GCS 3-8) TBI were hand-searched from medical databases using the terms "hyperbaric oxygen therapy, traumatic brain injury, and post-concussion syndrome". Glasgow coma scale (GCS) was the primary outcome, while Glasgow outcome score (GOS), overall mortality, and changes in post-traumatic stress disorder (PTSD) score, constituted the secondary outcomes. The results of eight studies (average age of patients, 23-41 years) reveal a higher post-treatment GCS score in the HBOT group (pooled difference in means = 3.13, 95 % CI 2.34-3.92, P traumatic brain injury.

  10. Escala de Coma de Glasgow: subestimação em pacientes com respostas verbais impedidas Escala de Coma de Glasgow: subestimación en pacientes con respuestas verbales impedidas Glasgow Coma Scale: underestimation in patients with verbal responses impeded

    Directory of Open Access Journals (Sweden)

    Maria Sumie Koizumi

    2005-06-01

    Full Text Available Questão freqüente no uso da Escala de Coma de Glasgow (ECGl, na fase aguda, em pacientes internados devido ao trauma crânio-encefálico (TCE é a subestimação decorrente de situações impeditivas como intubação endotraqueal/traqueostomia, sedação e edema palpebral. O objetivo deste estudo foi identificar e determinar a subestimação na pontuação total da ECGl quando se utiliza a pontuação 1 nas situações de impedimento para a sua avaliação. A amostra estudada foi de 76 pacientes internados com TCE no Hospital das Clínicas da FMUSP. Em 42 (55,3% pacientes, não havia impedimentos e foram realizadas 136 avaliações. Em 34 (44,7%, havia impedimentos caracterizados por intubação ou traqueostomia, podendo estar ou não associados com edema palpebral e sedação, e o total de avaliações foi de 310. A pontuação nesses pacientes total variou de 3 a 11, com os escores mais freqüentes de 3 e 6. Pelos valores estimados pela regressão linear, a partir das pontuações obtidas em AO e MRM foram obtidas as seguintes subestimações: média=1,03 ±1,36, mediana=0,54 (intubação ou traqueostomia; média=0,40 ±0,79, mediana=0,00 (intubação ou traqueostomia + sedação; média=0,57 ±0,96, mediana=0,27 (intubação ou traqueostomia + sedação + edema palpebral. Conclui-se que, no TCE grave, a pontuação total da ECGl fixando a MRV em 1, embora subestimada, encontra-se próxima da real.Cuestionamiento frecuente en el uso de la Escala de Coma de Glasgow (ECG, en la fase aguda, en pacientes internados debido al trauma craneoencefalico es la subestimación decorrient de situaciones impeditivas como intubación endotraqueal/traqueostomía, sedación y edema palpebral. El objetivo de ese estudio fue identificar y determinar la subestimación en la puntuación total de la ECG cuando es utilizada la puntuación 1 en las situaciones de impedimiento para su avaliación. La muestra estudiada fue de 76 pacientes internados por TEC en el

  11. Evaluación Microbiológica y Sanitaria de puestos de venta ambulatoria de alimentos del distrito de Comas, Lima - Perú

    Directory of Open Access Journals (Sweden)

    Juan J Quispe M

    2001-01-01

    Full Text Available Objetivo: Evaluar la calidad microbiológica y sanitaria de los puestos de venta ambulatoria de alimentos (PVAA del distrito de Comas. Materiales y métodos: De agosto a noviembre del 2000, se evaluaron la calidad microbiológica y sanitaria de 61 PVAA del Distrito de Comas, Lima-Perú. Para la parte microbiológica se analizaron el número de coliformes fecales y la presencia de Salmonella spp en muestras de alimentos (02, agua, superficies inertes y superficies vivas; y para la evaluación sanitaria se empleó una encuesta de factores de riesgo (20 características. Resultados: 60.7% de PVAA superaron los límites aceptables de coliformes fecales en una o más muestras analizadas. Por tipo de muestra de alimentos, 41.0% de PVAA tuvieron un alimento no apto para el consumo humano (NAPCH y 19.7% ambos alimentos NAPCH (coliformes fecales100 NMP/g, y respecto a las muestras de agua, superficies inertes y superficies vivas, se encontraron resultados microbiológicos inaceptables (coliformes fecales100 NMP/g en 32.8%, 42.6% y 49.2% de los PVAA, respectivamente. No se encontró Salmonella spp en ninguna de las muestras evaluadas. Sobre la evaluación sanitaria, 90.2% de los PVAA tuvieron "Riesgo Sanitario Alto", observándose deficiencias estructurales y culturales de manipulación e higiene de alimentos. Finalmente, se encontró relación entre los resultados microbiológicos; y las características de evaluación sanitaria. Conclusiones: La calidad microbiológica y sanitaria de los PVAA del distrito de Comas presentaron deficiencias, constituyéndose en un problema potencial de salud para nuestro medio.

  12. Analysis of survival, gene expression and behavior following chill-coma in the medfly Ceratitis capitata: effects of population heterogeneity and age.

    Science.gov (United States)

    Pujol-Lereis, Luciana Mercedes; Rabossi, Alejandro; Quesada-Allué, Luis Alberto

    2014-12-01

    The medfly Ceratitis capitata is an agricultural pest distributed worldwide thanks, in part, to its phenotypic plasticity of thermal tolerance. Cold exposure has been shown to reduce C. capitata survival, which may affect its distribution in areas with subfreezing temperatures. When insects are increasingly cooled, they attain a critical thermal threshold and enter a chill-coma state characterized by cessation of movement. It is not clear how a rapid cold exposure affects the physiological state of medflies, and how this is influenced by age and population heterogeneity. In order to approach these questions, C. capitata single-sex laboratory populations of 15 and 30 days old were subjected to a chill-coma recovery assay, and separated according to their recovery time in three subgroups: Fast-Subgroups, Intermediate-Subgroups, and Slow-Subgroups. Thereafter, we analyzed their survival, behavioral, and gene expression outputs. In female and old male populations, we found that flies with the slowest recovery time had a reduced life expectancy, a higher initial mortality rate, and a worse climbing performance compared with flies that recovered faster. Therefore, we were able to separate subgroups that developed chilling-injury from subgroups that had a reversible full recovery after cold exposure. The gene expression analysis of the heat shock protein genes hsp70 and hsp83 showed no clear association with the parameters studied. Interestingly, thorax expression levels of the Cu/Zn superoxide dismutase gene were elevated during the recovery phase in the Fast-Subgroups, but remained constant in the Slow-Subgroups that developed chilling-injury. On the other hand, none of the young male subgroups seemed to have suffered irreversible damage. Thus, we concluded that depending on age and population heterogeneity, chill-coma recovery time points out significant differences on individual cold tolerance. Moreover, the inability to properly induce the antioxidant defense system

  13. Three-dimensional kinetic modeling of the neutral and charged dust in the coma of Rosetta’s target comet 67P/Churyumov-Gerasimenko

    Science.gov (United States)

    Tenishev, Valeriy; Borovikov, Dmitry; Combi, Michael R.; Fougere, Nicolas; Huang, Zhenguang; Bieler, Andre; Hansen, Kenneth; Toth, Gabor; Jia, Xianzhe; Shou, Yinsi; Gombosi, Tamas; Rubin, Martin; Rotundi, Alessandra; Della Corte, Vincenzo

    2015-11-01

    Rosetta is the first mission that escorts a comet along its way through the Solar System for an extended amount of time. As a result, the target of the mission, comet 67P/Churyumov-Gerasimenko, is an object of great scientific interest.Dust ejected from the nucleus is entrained into the coma by the escaping gas. Interacting with the ambient plasma the dust particles are charged by the electron and ion collection currents. The photo and secondary emission currents can also change the particle charge. The resulting Lorentz force together with the gas drag, gravity, and radiation pressure define the dust particle trajectories.At altitudes comparable to those of the Rosetta trajectory, direction of a dust particle velocity can be significantly different from that in the innermost vicinity of the coma near the nucleus. At such altitudes the angular distribution of the dust grains velocity has a pronounced tail-like structure. This is consistent with Rosetta’s GIADA dust observations showing dust grains moving in the anti-sunward direction.Here, we present results of our model study of the neutral and charged dust in the coma of comet 67P/Churyumov-Gerasimenko, combining the University of Michigan AMPS kinetic particle model and the BATSRUS MHD model. Trajectories of dust particles within the observable size range of Rosetta’s GIADA dust instrument have been calculated accounting for the radiation pressure, gas drag, the nucleus gravity, the Lorentz force, and the effect of the nucleus rotation. The dust grain electric charge is calculated by balancing the collection currents at the grain’s location. We present angular velocity distribution maps of these charged dust grains for a few locations representative of Rosetta's trajectory around the comet.This work was supported by US Rosetta project contracts JPL-1266313 and JPL-1266314 and NASA Planetary Atmospheres grant NNX14AG84G

  14. Thermal Physics of the Inner Coma: ALMA Studies of the Methanol Distribution and Excitation in Comet C/2012 K1 (PanSTARRS)

    Science.gov (United States)

    Cordiner, M. A.; Biver, N.; Crovisier, J.; Bockelée-Morvan, D.; Mumma, M. J.; Charnley, S. B.; Villanueva, G.; Paganini, L.; Lis, D. C.; Milam, S. N.; Remijan, A. J.; Coulson, I. M.; Kuan, Y.-J.; Boissier, J.

    2017-03-01

    We present spatially and spectrally resolved observations of CH3OH emission from comet C/2012 K1 (PanSTARRS), using the Atacama Large Millimeter/submillimeter Array on 2014 June 28–29. Two-dimensional maps of the line-of-sight average rotational temperature (T rot) were derived, covering spatial scales 0.″3–1.″8 (corresponding to sky-projected distances ρ ∼ 500–2500 km). The CH3OH column density distributions are consistent with isotropic, uniform outflow from the nucleus, with no evidence for extended sources of CH3OH in the coma. The {T}{rot}(ρ ) radial profiles show a significant drop within a few thousand kilometers of the nucleus, falling from about 60 to 20 K between ρ =0 and 2500 km on June 28, whereas on June 29, T rot fell from about 120 to 40 K between ρ = 0 km and 1000 km. The observed T rot behavior is interpreted primarily as a result of variations in the coma kinetic temperature due to adiabatic cooling of the outflowing gas, as well as radiative cooling of the CH3OH rotational levels. Our excitation model shows that radiative cooling is more important for the J=7-6 transitions (at 338 GHz) than for the K=3-2 transitions (at 252 GHz), resulting in a strongly sub-thermal distribution of levels in the J=7-6 band at ρ ≳ 1000 {km}. For both bands, the observed temperature drop with distance is less steep than predicted by standard coma theoretical models, which suggests the presence of a significant source of heating in addition to the photolytic heat sources usually considered.

  15. A escala de coma de Glasgow como indicador de mortalidade e qualidade de vida em vítimas de trauma cranioencefálico contuso

    OpenAIRE

    Cristina Helena Costanti Settervall

    2010-01-01

    As consequências do trauma cranioencefálico contuso incluem além da mortalidade, alterações físicas, cognitivas e comportamentais que alteram a qualidade de vida das vítimas pós-trauma. A Escala de Coma de Glasgow é reconhecida na literatura científica, como um indicador com potencial para estimar o prognóstico das vítimas de trauma cranioencefálico contuso e tem sido extensivamente estudada para prever resultados a curto e longo prazos. No entanto, por tratar-se de um índice fisiológico, su...

  16. Aplicaciones de la aritmética en coma fija a la representación de primitivas gráficas de bajo nivel.

    OpenAIRE

    2012-01-01

    La aritmética en coma fija tiene la propiedad de realizar operaciones con números decimales con un coste computacional entero. A pesar de no estar soportada de forma nativa por los lenguajes de programación y por las CPUs generalistas, es la aritmética ideal para aplicaciones de control industrial, simulación, informática gráfica, multimedia y señal digital, etc. Su falta de normalización y soporte impide su uso extendido en muchos campos de la informática. Esta tesis justifica la utilizac...

  17. Prevention of methionine and ammonia-induced coma by intravenous infusion of a branched chain amino acid solution to rats with liver injury.

    Directory of Open Access Journals (Sweden)

    Shiota,Tetsuya

    1984-10-01

    Full Text Available The prevention of hepatic encephalopathy by the intravenous infusion of a branched chain amino acid (BCAA-enriched solution was investigated in methionine and ammonium acetate-treated rats whose liver was already injured with carbon tetrachloride. A BCAA-enriched solution protected the rats from entering a coma. The brain BCAA contents became higher, and the brain methionine and tyrosine levels and the ratio of glutamine to glutamic acid in the brain diminished after administering the BCAA-enriched solution.

  18. Ocultaciones Estelares por coma cometaria: ocultaciones por 78P/Gehrels 2 69P/Taylor y 81P/Wild2T

    Science.gov (United States)

    Duffard, R.; Licandro, J.; Serra-Ricart, M.; Oscoz, A.

    Six occultations of stars by the coma of comets 78P/Gehrels 2, 69P/Taylor, and 81P/Wild 2 have been observed using the 82cm IAC-80 telescope at Teide Observatory (Canary Island, Spain). Time series CCD images using R broadband filter were done. No star brightness extinction was detected even for the closest approach (400 Km from the nucleus). A detailed explanation of the reduction procedure and a discussion on some effects that can produce ``false" drops of the measured star magnitud is presented.

  19. Clinical Observation on Resuscitating Acupuncture Treating Coma Patients%促醒针法治疗昏迷患者临床观察

    Institute of Scientific and Technical Information of China (English)

    王小寅; 陈文君

    2014-01-01

    Objective:To observe the clinical efficacy of resuscitating acupuncture on early coma patients. Methods:80 coma patients were randomly divided into control group (40 cases) and treatment group (40 cases), control group received routine treatment for coma, treatment group adopted re-suscitating acupuncture and basic treatment, to evaluate GCS score and conscious state of the two groups after 8 weeks. Results:GCS score of treat-ment group was significantly higher than that of control group (P<0.05);GCS score of patients with craniocerebral trauma was significantly higher than that of patients with cerebrovascular accident in treatment group after treatment (P<0.05);the total effective rate of the experimental group were significantly higher than those in control group (P<0.05). Conclusion:Resuscitating acupuncture has certain resuscitating effects on coma patients, es-pecially in patients with craniocerebral trauma, prognosis in patients of GCS score≥7 points is better.%目的:观察促醒针法对早期昏迷患者的临床疗效。方法:80例昏迷患者随机分为对照组(40例)和治疗组(40例),对照组常规治疗昏迷,治疗组采取促醒针法及基础治疗,评价两组患者疗效、GCS评分及意识状态。结果:治疗组GCS评分明显高于对照组(P<0.05),治疗后治疗组颅脑外伤患者GCS评分显著高于脑血管意外患者(P<0.05);实验组总有效率均显著高于对照组(P<0.05)。结论:促醒针法对昏迷患者有一定促醒效果,能加速促醒及提高促醒成功率,颅脑外伤者疗效较为显著, GCS评分≥7分者预后较好。

  20. Continuous renal replacement therapy circuit failure after antidote administration.

    Science.gov (United States)

    Jeong, Jinwoo

    2014-12-01

    A 73-year-old man was transferred to the emergency department (ED). He was found unconscious in his house along with an empty 200-mL bottle of Basta(™), a herbicide containing 18% glufosinate. He was comatose with a Glasgow Coma Scale score of 3. As his blood pressure dropped to 60/30 mmHg despite fluids and norepinephrine, 20% intravenous fat emulsion product was injected. He experienced repeated cardiopulmonary arrests during his first 4 h in the ED. When the arrests occurred, standard cardiopulmonary resuscitation was performed, and boluses of fat emulsion were given. He was given a total of 1500 mL of 20% fat emulsion. In an attempt to correct the acidosis, continuous renal replacement therapy (CRRT) was started. Within 5 min of starting CRRT, the transmembrane pressure increased sharply and the machine stopped.